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For the month of February, museums throughout San Diego will be half-off. Megan Tevrizian visits the Air and Space Museum in Balboa Park to get a behind-the-scenes look at the biggest space exhibit.
Pass holders can bring up to three other people with them who can also be eligible for the discounted admission.
For more information about SDASM click here.
We have successfully crowdfunded what we need to get our Data Sharing Portal started, and we’re looking for NTD drug discovery labs to participate! Click HERE for more info about the model!
Our $25,000 crowdfunding campaign was successful, and we’re off and running! Read below about what we’re doing, and visit this survey to share your details if you want to participate!
I’ve selected excellent leads from the Tres Cantos Antimalarial set. Who else has already pursued these lead classes? Are they still actively working on them? Has this lead class been deprioritized for any reason?
Has anyone developed structure-activity relationships in related chemotypes?
Has anyone established a pharmacophore model or identified a target of action for these compounds?
I have a good parasite growth assay – are there chemists who want to collaborate with me to optimize new compounds?
I am a chemist branching into NTD drug discovery – what biology groups would like to collaborate?
What assays and disease models are considered to be the gold standard by MMV or DNDi? Does anyone have these set up?
Identify opportunities for organizations (pharma, biotechs, CROs) to provide in-kind contributions of screening resource, in vitro ADME testing, pharmacokinetics, or safety to labs involved in the consortium.
Provide opportunities for sharing compounds and information across pathogens. For example – are the inhibitors that are effective against malaria also effective against Leishmania?
Discuss parameters for harmonized assay cascades that will be most directive towards the targeted product profiles advanced by MMV, DNDi, and others for new drugs for NTDs. For example – what selectivity assays should be used, in order to be able to compare results? What data do funders actually look for?
Higher visibility – we will regularly communicate the progress of our Open Source effort to key stakeholders in NTD drug discovery.
We will set ground rules within the group regarding data sharing, use of each other’s’ data, and we will work to find good mechanisms of intellectual property management.
What are we not trying to do?
We are not trying to force anyone to collaborate with anyone.
We are not trying to become the center of the universe for NTD drug discovery.
We are not trying to dissuade anyone from pursuit of any chemotypes – only to share information so best decisions can be made by participating investigators.
We are not trying to establish a shared research portfolio.
We are not going to dump everyone’s data into the public domain.
As an Initiative, we don’t necessarily intend to apply for large grants that tie projects together, though we will likely seek funding for database support and other collaboration tools.
Does this sound even a little bit interesting? Then please do the following: Get in touch with me m.pollastri@neu.edu or tweet @NUTrypkiller Check out our CrowdFunding effort on our Microryza page We are targeting a formal launch date in December 2013!
The Pollastri Group © 2019. All Rights Reserved.
A MUCH-LOVED pensioner who survived the Glen Cinema disaster will have her last request granted...by being laid to rest with a copy of the Paisley Daily Express in her coffin.
Jeanie McGuire Anderson was just a young girl when she was caught up in the tragedy which became known as Paisley’s Black Hogmanay.
More than 70 young lives were lost on December 31, 1929, when fears of a fire caused a stampede at the Glen Cinema, just off Dyers Wynd, Paisley.
Although she went on to live to the ripe old age of 89 before she passed away peacefully on January 2, Jeanie never forgot what happened that dreadful day.
Jeanie’s funeral will take place tomorrow and her family will make sure she gets the send-off she deserves.
Her niece, Molly Young, said: “She was a really nice lady and was a fantastic aunt and great aunt to all of her nieces and nephews.
Jeanie was born and raised in the Mossvale area of Paisley and then lived in the Foxbar part of town for around 60 years.
She had gone to the Glen Cinema with her pal Ina Brown on Hogmanay 1929 when disaster struck.
Almost 1,000 excited youngsters had packed into the cinema to watch a matinee showing of the cowboy movie Desperado Dude.
Within minutes, their happiness turned into a hellish nightmare as a smoking reel of film caused panic.
The children mistakenly believed there was a fire and that started a stampede towards the exit doors, which were locked.
Some of the youngsters suffocated, while others were trampled to death against the locked doors as they fled a fire that never was.
Molly said: “Jeanie spoke about what happened at the Glen Cinema quite a lot and made it to the annual memorial service in Paisley two years ago.
“She had been at the cinema with a friend and said they were all shoving and panicking, falling over each other.
Jeannie also told her story when she took part in the making of a DVD called The Legacy of the Glen Cinema – produced by filmmaker Paul Mothersole in association with the Paisley Development Trust – which was released in 2009 to coincide with the 80th anniversary of the tragedy.
She explained how Ina had asked her to go to the cinema that fateful day and recalled the panic caused by the smoking reel of film.
Jeannie said: “We started to get up and this chap was in front of us. He was carrying a baby and he would be maybe about 14 or something like that.
“I started to go my road – a different way. I had to go upstairs to get out. When I got up those stairs, I was facing the Cart. I was crying.
“These two women, who lived in the next close to me, said ‘What’s wrong with you?’ I said ‘Oh, I’ve lost Ina Brown. I cannae get Ina Brown.
Jeanie went on to work for Rolls-Royce and was also a Land Girl in the Women’s Land Army during the Second World War.
She looked after her late mother, Williamina Anderson, and for decades attended St Columba Church, in Foxbar.
In recent years, Jeanie was cared for at the Elderslie Care Home after becoming ill with breathing problems, dementia and pneumonia.
As well as Molly, she was also an aunt to Marilyn and Jack and a great aunt to lots of nieces and nephews, including Shirley, Paul, Marion, Sharon and Jackie.
Jeanie’s funeral service will take place at Woodside Crematorium, in Paisley, at 2pm tomorrow.
Piero Pieraccini, chairman of the Paisley Development Trust, said everyone involved in the DVD project was “very saddened” to hear of Jeanie’s death.
He added: “Jean, along with all the other survivors, worked closely with us to create the Glen Cinema Exhibition in 2004, which commemorated the 75th anniversary of the disaster.
“Her contribution to the exhibition and the subsequent film The Legacy of the Glen Cinema was invaluable.
“The viewers of the film were able to gain an insight into the terrible events of that fateful day in 1929 due to Jean telling her story. We are indebted to her for her openness and willingness to discuss what will have been a very painful time in her life.
This week our roundup of adorable videos includes a baby being calmed by none other than the Notorious B.I.G., a funny doggy costume, a pug that hates the iPhone, and more. So sit back, relax and prepare yourself for some major cuteness!
We hope you’re ready for cute overload because Monday is here, which can only mean one thing—it’s time for our Weekly Dose Of Cute! This week our roundup of adorable videos includes a baby being calmed by none other than the Notorious B.I.G., a funny doggy costume, a pug that hates the iPhone, and more. So sit back, re...
This video of a crying baby that instantly calms down when she hears Biggie has been viewed almost 1 million times this week. What music calms you down?
This dog’s owner attached a GoPro HD cam to a big stick and got a view of his dog like none you’ve ever seen! It’s pretty funny watching this dog’s face and eyes as he runs around the yard. This video has been viewed over 110,000 times since it hit YouTube a week ago.
Star Wars fans—look out for that Hoth Wampa! Oh, nevermind…it’s just a Wampug.
Speaking of pugs—this pug absolutely hates iPhones. He watches TV calmly, until an iPhone commercial comes on. Then he goes crazy!
And finally, while the protests continue on Wall Street one little pup makes friends with an NYPD police horse. This adorable video has been viewed over 1 million times!
Should the Surfside Beach Pier be rebuilt?
SURSIDE BEACH, SC (WMBF) – Surfside Pier has been a huge attraction until it was destroyed by Hurricane Matthew.
Now, town leaders say there's no guarantee Surfside Pier will be rebuilt.
The Myrtle Beach Chamber of Commerce and Surfside town leaders recognize the pier is a major attraction.
And while locals will have their voices heard at several town meetings about whether it should be rebuilt or not, they decided to take a survey to visitors so they can have a say too.
In January, more than 300 people took the survey.
They stayed in three different Surfside lodging businesses that had previously registered their email addresses with the businesses.
According to the survey, 96.3 percent say they have visited the pier during their stay.
With 31.6 saying they spent $50 or more at that pier.
But one of the last questions that put a stamp on why the town shouldn't be slow at considering options was, do you think the pier should be rebuilt?
86 percent of surveyors say yes with the majority of others marking undecided.
The Surfside Beach Resort General Manager says while locals' opinions matter, visitors concerns also have a significant impact.
"The survey is pointed, visitors use the pier, visitors enjoy the pier it's an iconic part of the town of surfside beach, it's an important of not only our history but our future," Surfside Beach Resort GM Phil Vassar said.
During Hurricane Hugo, the pier was privately owned and insured which made it easier to rebuild.
In 2016, 6,000 guests visited the pier and that's just from documented hotel vouchers.
But that's why a survey was drawn up to see if rebuilding the pier affect people who visit.
Of the 362 surveyors, 25 percent of those people say they wouldn't come back if the pier wasn't rebuilt.
According to that number, it's a huge risk because that would mean the town wouldn't receive 25 percent of tax based income that's needed to run the town.
Vacation rentals would take a loss because that 25 percent of people who wouldn't return would affect the possibility of them eventually buying or renting a house or even retiring.
So WMBF asked the Surfside Beach Resort General Manager if the town decided not to rebuild the pier, what would be the next step to make sure people continue to come back year after year.
"It means were going to have to rebuild surfside in some way, rebuild around something else because this town is built around that pier and the ocean it serves," Vassar said.
Organizers of this survey say now that the survey has been completed and results are in, they hope the town of Surfside Beach will see the importance in the numbers.
WMBF also asked if it would be possible if any sort of tax would be placed on residents to help fund the pier if the town ran out of options.
We're told if it came down to it, funding would be placed on businesses. Something leaders say they are not in favor of.
Amazon confirmed Tuesday that it is opening up pop-up stores in San Francisco and Sacramento, California, next week for the holiday shopping season.
The pop-up stores will carry Amazon-branded e-readers, tablets, smartphones, and streaming media players. “While customers can already see our products online and at retailers like Best Buy and Staples, we wanted to provide another option to try out our full lineup leading into the holidays,” a representative told Fast...
The news comes on the heels of a report from last week that the online retailer will soon open a brick-and-mortar store in Manhattan, across the street from the Empire State Building.
Unlike the holiday pop-up stores, the retail location on 34th Street could function like a warehouse, fulfilling and delivering packages the same day orders are placed. In addition, reports suggest customers could exchange or return products at the location.
Be sure to check out more hikes at our complete Vail Valley hiking guide.
July 15, 2008 — To hike is one thing – to find a hike for all abilities, which will bring you home in time to make the evening’s events, is another thing entirely.
With Bravo! Colorado bringing world-famous orchestras to town, and the Vail International Dance Festival coming up, plus the Hot Summer Nights concert series and everything else that’s going on, people tend to want to head for a nearby hike which will get them back in time for the evening’s events.
Ideally the hike is flexible enough for the whole family, too – so that kids and grandma can come along if they want, and everyone can hike for as short a time, or as long, as they wish.
My No. 1 recommendation for this is Bighorn Creek Trail in East Vail. It’s very steep at first, but don’t let that get you down. Conquer that first hill and it’s much easier from there on out. It’s also less crowded, usually, than nearby Booth Creek Falls trail.
Take a look at the description below, and if you’re looking for more recommendations for yourself, or your friends and family, then visit our complete guide to Vail hiking.
ACCESS FROM VAIL: Travel east from Vail on I-70 to Exit 180 for East Vail. Exit here and turn to the right. Proceed on the south frontage road for 1 mile to Columbine Drive, turn left. Continue to the end of the pavement; the road passes under the interstate through a narrow passage. There is limited parking at the end...
TRAIL BEGINNING: 8,600 ft at the end of Columbine Road.
TRAIL ENDING: 10,800 ft at the old homestead cabin.
HIGHEST ELEVATION: 10,800 ft (3300 m) at the end of the trail.
Elevation gain: 2,200 ft in 3.6 miles.
RECOMMENDED SEASON: June through September.

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