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Live updates: Warriors vs. Rockets, Thursday at 7:30 p.m. |
Join us for live news and analysis Thursday at 7:30 p.m. as the Warriors take on James Harden and the Houston Rockets in a nationally televised game at Oracle. |
The Warriors (25-13) are riding a two-game road winning streak into Thursday’s game, but they’ll also be armed with the knowledge they were embarrassed the last time they faced Houston. Harden scored 27 points as Houston rocked the Warriors 107-86 at home on Nov. 15. The Warriors didn’t have Stephen Curry in that game. |
Golden State must figure a way to slow down Harden, the NBA’s leading scorer at 33.3 points per game. He’s scored at least 40 points in the past four games and has an eight-game streak of scoring 35 points or more. Harden scored 43 points on Monday when the Rockets handed the Grizzlies a 113-101 defeat. |
Even with star point guard Chris Paul out with a hamstring injury, Houston (21-15) has won five straight games and 10 of its last 11. |
The Warriors are coming off an impressive 132-109 victory in Phoenix on Monday as Curry poured in 34 points on 11-of-17 shooting. |
Golden State’s next game is Saturday in Sacramento against the improved Kings. |
Incredible pic here from @jcfphotog of Harden’s game winner. https://pbs.twimg.com/media/DwDGLNhX4AAfjif.jpgColdblooded gamewinner https://pbs.twimg.com/media/DwDGfBlVAAEYgPo.jpgIncredible pic here from @jcfphotog of Harden’s game winner. https://pbs.twimg.com/media/DwDGLNhX4AAfjif.jpg“Steph is perfectly comfortable pl... |
Lol urkle relentlessI asked Harden about his confidence level right now. Said, "Through the roof." More so after tonight? "It's been like that."Kevin Durant said he knew he was out of bounds on late play, but wasn’t surprised he didn’t get called. Durant observed that officials missed a lot of callsNot sure any city ca... |
As it has been for 4.5 straight years and counting. You never beat the Warriors, they just mess things up themselve… twitter.com/i/web/status/1…Steph was willing to use clock... but he saw Kd clap and gave it upOT Win At Oracle! |
Jonas: 5p/2r https://pbs.twimg.com/media/DwC_kxqU8AUw1zm.jpgSteve Kerr said he wasn’t happy with the late foul call on Draymond Green on Harden. Kerr said he thought Green got verticality on the play.D"Antoni thought maybe, perhaps James Harden got himself in the MVP conversation. Told Harden launched 23 3she laughed f... |
In fact, we are being denied Steph… twitter.com/i/web/status/1…M.V.P. |
New rotation of pulling him with 7 mins left in 4th Q and bringing him back 3 mins later not working... Kills rhythmUp 6 with ball and 1:10 left. You gotta bring that game homeBut seriously, that was an insane shot by Harden.BIG COMEBACK DUB! 🚀 https://pbs.twimg.com/media/DwC8vrTU8AASu5g.jpgWow Klay was wide open for ... |
Did Valeant Pharmaceuticals Make Another Bad Bet? |
ConcernValeant Pharmaceuticals practice of buying and rebranding existing medications, often with much higher price tags, will lead to payer pushback that crimps sales and has caused the company's shares to be lambasted over the past two months. |
Now, recent prescription volume trends suggesting that its newly acquired women's Viagra pill, Addyi, may be a dud could mean that management similarly miscalculated when it forked over $1 billion in August to acquire Addyi's drug developer, Sprout. |
Effective...but riskyDuring clinical trials, women with hypo-active sexual desire disorder reported that taking Addyi led to more frequent and satisfying sexual events per month, but findings also uncovered some safety issues that could be keeping doctors from writing scripts. |
Specifically, patients taking Addyi that drink alcohol could be at greater risk of losing consciousness. A study evaluating the interaction of Addyi and alcohol found that 17% of 25 patients that took Addyi and drank two five-ounce glasses of wine over a 10-minute period required therapeutic intervention, such as smell... |
Additionally, studies have shown that without alcohol, 0.4% of Addyi patients and 0.2% of placebo patients also required intervention. |
Because of the risk of unconsciousness, Addyi's label includes a black box warning and the FDA requires participation in a risk mitigation strategy, or REMS, that mandates educating doctors and patients on Addyi's safety risks. |
Addyi's safety profile has also kept some payers from adding Addyi to preferred tiers of their drug formularies, thereby limiting reimbursement for the drug. |
For example, Addyi is in the third tier of Anthem's drug formulary and that means that patients pay more for it than they do for generics or preferred brand drugs. Similarly, Express Scripts has Addyi listed as non plan preferred in its formulary, which suggests that Addyi is subject to the highest patient co-pay. |
Nonexistent demandPfizer ended up with a mega blockbuster on its hands with Viagra, but tepid early demand for Addyi suggests that Valeant may struggle to justify its billion dollar purchase. |
Addyi has been on the market for only a few weeks and during this period, only 227 prescriptions have been written for it. |
That's a far cry shy of the mammoth demand Pfizer's Viagra enjoyed when it launched In 1998. During Viagra's first month on the market, Pfizer reported a half million prescriptions. |
Admittedly, these two drugs are very different from one another. Addyi targets brain chemistry to boost women's libido, while Viagra targets blood flow, and because they have different mechanisms of action, it's probably not too shocking that they have dissimilar safety profiles and thus, different stories of... |
Looking forwardThe FDA REMS may be a big reason for Addyi's slow start. Getting certified to prescribe Addyi isn't a deal-breaker, but it can be time consuming and with absent demand from patients, doctors are likely focusing on more pressing matters. |
Insurer reimbursement could also be a barrier that needs to be overcome, but insurers such as Anthem and Express Scripts aren't likely to improve reimbursement for the drug given that they're knee deep in trying to reduce drug expenditures and therefore, their focus is to reimburse at the lowest levels possib... |
If the pathway to certification gets easier and insurers reimburse more willingly, perhaps Valeant can use direct-to-consumer advertising to increase sales, but I wonder if any of those developments would be enough to overcome Addyi's risks, and for that reason investors that are considering buying Valeant's ... |
The article Did Valeant Pharmaceuticals Make Another Bad Bet? originally appeared on Fool.com. |
Todd Campbell has no position in any stocks mentioned. Todd owns E.B. Capital Markets, LLC. E.B. Capital's clients may have positions in the companies mentioned. The Motley Fool owns shares of and recommends Express Scripts and Valeant Pharmaceuticals. The Motley Fool recommends Anthem. Try any of our Foolish news... |
Hillary Clinton is the Great Underestimator. Eight years ago, she underestimated Barack Obama and now she has underestimated Bernie Sanders. We know this not only from what happened in 2008 and what is happening now but from the pitiful confessions of her campaign staff who admit they never saw Sanders coming. That’s u... |
I come at this column as a Clinton supporter. I like her personally and have enormous respect for her intelligence. Mostly, though, she’s the classic one-eyed person in the land of the blind: Who else is there? Pray, not Bernie Sanders. If he played Capt. Renault in “Casablanca,” he would have said, “Break up the big b... |
Clinton has her own tic. She has plans. She has a one-point plan and a two-point plan and, most often, a three-point plan. A three-pointer is always best since it suggests a beginning, a middle and an end. It mimics the three-act structure of movies and plays that, for some reason, we find so satisfying. Clinton has a ... |
At Sunday night’s debate, Clinton was somewhat less than candid about her foreign policy differences with her former boss. (As secretary of state, she favored a more muscular policy.) But what matters more to her political chances is this business of hiding behind plans. She talks like a chief of staff, which in a sens... |
Frankly, I don’t give a damn about her plans. I sort of already know what they are anyway. After being first lady, senator from New York, secretary of state and, going all the way back, the 1969 commencement speaker at Wellesley College, she can’t possibly have any surprises up her sleeve. When it comes to policies and... |
She could have gone further. She could have mentioned how some children are already beyond hope. Their IQs have dropped. They are lethargic. They have lead poisoning. An ugly piece of the Third World was brought to Michigan under a governor who had hitherto boasted how his business experience made him better than your ... |
But Clinton did not mention the kids. She did not even go to Flint. |
(1) Sent an aide. (2) Issued a statement. (3) Went on TV. |
Sanders at that point chimed in, adding that he had called on Michigan Gov. Rick Snyder (R) to resign. |
Clinton’s shortcomings as a candidate amount to a national crisis. As things now stand, the Republican nominee could be either Donald Trump or Ted Cruz. If she can’t handle Sanders, she probably can’t handle either of them. She needs to get a different three-point plan. (1) Say what’s on your mind. (2) Get angry. (3) N... |
On the wall of Darren McKnight's office, in Reston, Virginia, is a display that would give pause to anyone who might be considering a trip into space: two gnarled pieces of metal shot through with shredded electrical wires and mangled rivets. They are fragments of a Navy satellite that was shattered during a test in a ... |
Everything that human beings launch high enough into space will ultimately end up like that shattered satellite. As long as an object is above the last traces of Earth's atmosphere, it will stay in orbit for thousands or even millions of years. Eventually, whether a month or a millennium after launch, it will hit one o... |
The space shuttle Endeavor is scheduled to ferry the first U.S.-built component of the International Space Station into orbit several months from now. A steady stream of modules and structural elements will follow over the next five years. If the station remains in space, it will eventually collide with a piece of debr... |
Today the risk of such a disaster for a satellite or a small craft like the shuttle is relatively low, though Mir, the Russian space station, launched in 1986, has been hit by objects large enough to dent the inner wall of the crew compartment. But the International Space Station, much larger than Mir, will be a plump ... |
Venturing into space is inherently risky, and orbital debris is just one of many hazards that a space traveler faces. But the debris hazard is unique in being a product of our environmental negligence. After just forty years in space we have seriously polluted the final frontier. Valuable orbits are peppered with debri... |
Space may seem remote, but it's really not that far away. If you could drive your car straight up, in just a few hours you'd reach the altitude at which the space shuttle flies. The popular orbits for satellites begin twice as far up—about 400 miles above our heads. The only satellites that are truly distant from Earth... |
Since 1957 the United States and what is now the former Soviet Union have conducted about 4,000 space launches (the launches conducted by all other countries and international organizations combined account for just a few hundred additional forays into space). The leftovers from these launches—used-up satellites, the r... |
Many of the objects released into space in the lowest orbits, like Collins's camera, have fallen back to Earth. The upper atmosphere, where the space shuttle flies, gradually slows objects down; they re-enter the atmosphere and burn up within a few months or years. But a few hundred miles higher the atmosphere is so th... |
Today radars that were designed to scan the horizon for incoming Russian missiles track a silent armada of space junk instead. The U.S. Space Surveillance Network routinely follows more than 8,000 objects that are larger than four inches across, which is approximately the lower limit of detectability for current techno... |
Especially troublesome are pieces of the more than a hundred rockets and satellites that have exploded in orbit. At the end of their useful lives spacecraft typically contain some fuel left over from launch or from orbital maneuvers. The fuel tanks deteriorate over time or are punctured by debris. The leftover fuels mi... |
It was the explosions of derelict rockets that first drew NASA's attention to debris. In the 1970s Delta rockets left in orbit after delivering their payloads began blowing up. An investigation by McDonnell-Douglas, their manufacturer, showed that the bulkheads separating the leftover fuels were probably cracking as a ... |
Eventually the number of explosions will diminish, but by then spacecraft will be breaking up for another reason. As more objects go into orbit, spacecraft will begin colliding with—and being shattered by—debris. Furthermore, collisions beget more collisions. This process is known as collisional cascading, or the Kessl... |
Debris researchers argue vigorously about whether collisional cascading has begun. Technically, a "cascade" begins only when a piece of debris formed in one collision causes a subsequent fragmentation—an as yet undocumented occurrence. But no one disputes that space is becoming a more dangerous place. Two years ago an ... |
Once collisional cascading begins, the number of objects in a particular orbit will gradually increase—and the risk to satellites and manned spacecraft will rise accordingly. A team of researchers in Italy, collaborating with Alessandro Rossi, a research fellow at the National Research Council of Italy, has calculated ... |
For many years NASA and the Department of Defense were skeptical about the dangers of space debris. The problem seemed abstract, residing more in computer models than in hard experience. And it challenged the can-do mentality of space enthusiasts. Earth's orbit seemed too large and empty to pollute. |
To its credit, NASA has long maintained a debris-research program, staffed by top-notch scientists who have persisted in pointing out the long-term hazards of space junk even when the higher-ups at NASA haven't wanted to hear about it. Then came the Challenger accident, in 1986. NASA officials realized that their empha... |
Engineers took a new look at the shuttle and the International Space Station. Designed in the 1970s, when debris was not considered a factor, the shuttle was determined to be clearly vulnerable. After almost every mission windows on the shuttle are so badly pitted by microscopic debris that they need to be replaced. So... |
But adding shielding and repair kits won't solve the real problem. The real problem is that whenever something is put into an orbit, the risk of collision for all objects in that orbit goes up. Therefore, the only truly effective measure is a process known as deorbiting—removing objects from orbit when they reach the e... |
The logic behind deorbiting has been inescapable since the beginning of the Space Age, yet it has just begun to penetrate the consciousness of spacecraft designers and launchers. In 1995 NASA issued a guideline saying that satellites and the upper stages of rockets within 1,250 miles of Earth should remain in orbit for... |
Furthermore, the character of the Space Age is changing. Of the eighty-nine launches that took place worldwide last year, almost half carried commercial communications satellites. The private sector now puts more payloads into orbit than do NASA and the U.S. and Russian militaries combined. A score of communications co... |
None of these companies is under any obligation to limit orbital debris. Companies that are launching large constellations of satellites are worried about collisions between the satellites, and they are well aware that a public-relations disaster would ensue if a piece of a shattered satellite smacked the station. As a... |
Government regulations covering orbital debris are still rudimentary. For now, the federal agencies that have authority over commercial launches are waiting to see if the private sector can deal with the problem on its own. But deorbiting rockets and satellites is expensive. A satellite could keep operating for several... |
International regulation will be even more difficult. Already the Russians and the Europeans launch a significant number of U.S. commercial satellites. U.S. launch companies would howl if the government imposed unilateral restrictions on spacecraft launched from U.S. territory. Extending restrictions internationally wo... |
Human societies have done plenty of things that we or our descendants may someday regret. At the beginning of the Atomic Age we seriously polluted vast tracts of land that will take many billions of dollars to clean up. We have increased the amount of carbon dioxide in the atmosphere despite a scientific consensus that... |
One reason for our nonchalance is that new technologies have gotten us out of many past scrapes—and maybe they will with orbital debris, too. Perhaps a future spaceship will race around Earth grabbing old spacecraft and flinging them back into the atmosphere, though it is hard to imagine a similar clean-up method for t... |
But no such technologies are available today. Two years ago a distinguished National Research Council committee concluded that "active removal of debris will not be an economical means of reducing the debris hazard in the foreseeable future." Even if some such technology were developed, it would probably be much more e... |
In 1987 the World Commission on Environment and Development defined sustainable development as meeting the needs of the present generation without compromising the ability of future generations to meet their needs. In space we are failing the sustainability test miserably. A hundred years from now, when our descendants... |
PARTS of the region shivered through the coldest day of the year so far, with some areas dropping to 5.4C. |
According to Bureau of Meteorology's data from the Gladstone Airport weather station, the temperature dropped to 5.4C yesterday and 7.8 on Saturday. |
But it wasn't enough to break records for Gladstone. |
According to BoM, the lowest temperature recorded at Gladstone Airport in July remains on July 12, 2014, at 4.5C. |
The coldest day in Gladstone was on August 1, 2003, when it dropped to 3.5 degrees. |
The maximum temperature recorded was 25C and 22.9C respectively. |
The cold change was felt throughout most of the state last weekend. |
Gladstone's western neighbour, Thangool, had a minimum temperature of -2.3C d yesterday and -0.6C on Saturday. |
Bureau of Meteorology forecaster Gordon Banks said a large mass of dry, clear air sitting over southern Queensland, the long nights and light winds caused the cold snap. |
"The main factors are: it's not cloudy, it's very dry and we're seeing little wind at night," Mr Banks said. |
He said the temperature would increase today, with a minimum of about 10C, before increasing to the mid-teens by Thursday. |
The BoM expects another cold change early next week. |
AUSTIN, Texas, Nov. 9, 2018 (SEND2PRESS NEWSWIRE) -- EyeBuyDirect today announced a new line of RFLKT glasses designed with the winter months in the forefront. New styles released include Planete, Illusion, Resonance, Luminous and Era, and will be available starting November 12. The five new frames in EyeBuyDirect's pr... |
NEWPORT BEACH, Calif., Nov. 9, 2018 (SEND2PRESS NEWSWIRE) -- NotaryCam today announced it would offer free remote online notarization (RON) sessions to United States veterans and current service members in honor of Veterans Day as part of its semi-annual "Help a Hero" initiative. From Friday, Nov. 9 through Monday, Nov... |
To understand Agnes of God, a "psychological/supernatural thriller" from 1979, maybe it's helpful to look a little harder at the more ancient and epic battle it represents. On the surface, John Pielmeier's drama seems to be a psychobabble-laden tug-o-war between believers and a damaged, analytical mind fallen away from... |
Even with all the news about "fake news" we take the primacy of facts for granted these days, but all in all, they're a relatively new concept. As emerging sciences elevated empirical knowledge during the Renaissance the very idea of fact-based learning challenged and chipped away at the church's supreme authority. Pro... |
More frustrating: As the play's ancient polemic reveals itself, the more apparent it becomes that Agnes, a helpless creature who's been raped by her author if by nobody else, has little meaning to either side of this debate outside of how she might serve self interest or self-preservation. To that end she's both the ti... |
What Agnes of God does that we can all be thankful for is provide three women with some extremely showy acting opportunities. New Moon Theatre's cast and crew delivers all the fireworks you could possibly hope for. It's a remarkable convergence of talent with Kim Justis stepping into the part of Dr. Livingston, Susan B... |
Some quilts will be available for purchase. |
Guild members are setting up a boutique, and vendors also will be a part of the event. |
Silent auction items include a sewing machine and a quilt kit. The church's United Methodist Women's group will have baskets handmade by women in Guyana and will sell breakfasts and lunches. |
"And the quilting is not just bed quilts. There will be dolls, pillows, a jacket," Martin said. |
The Magnolia Quilters also are offering an "opportunity quilt" at $1 per chance. The 110-by-110-inch (king size) quilt was pieced by members of the guild and professionally quilted by Susie Jackson of Hattiesburg. It was appraised for more than $1,800. |
The drawing for the quilt will be Saturday afternoon, and the winner does not have to be present. Proceeds will go toward two organizations the Magnolia Quilters work with: CASA and the neonatal intensive care unit of Memorial Hospital at Gulfport. |
In addition, a quilt appraiser, certified by the American Quilting Society, will be on hand. "For a nominal fee, she will appraise your quilt, let you know the approximate value or when it was made, or if it's damaged, if it's worth restoring," Martin said. |
BHP Billiton Ltd. announced its yearly profits climbed 23%, as it outlined plans to create a new company to accommodate assets including nickel mines and aluminum smelters that would be listed on Australia's stock exchange. |
Australia’s biggest company, BHP reported a net benefit of US $13.83 billion for the year through June, after delivering more iron metal from mines in the west of Australia and mushrooming expense cuts. The result was in accordance with the average US $13.86 billion conjecture of seven experts surveyed by The Wall Stre... |
BHP currently focused on upgrading its strategy to concentrate on delivering iron metal, copper, coking coal and petroleum. Vital to that move is a spinoff of an accumulation of assets that as of not long ago were a tow its expected profits. |
On Tuesday, BHP said it would make an organization to accomodate its whole aluminum and manganese business, in addition to individual mining stakes that incorporate its Cerro Matoso nickel mine in Colombia and its Cannington pit in Australia that creates silver, lead and zinc. The new organization will additionally own... |
A majority of assets were gained by BHP in its transformational takeover of the U.K's. Billiton PLC in 2001, and the move is the most recent change inside the mining segment far from an extensively differentiated holding base in the midst of a sharp withdrawal in costs of numerous commodities. BHP’s financial specialis... |
"In a single step, we will significantly increase BHP Billiton's focus on the exceptionally large resource basins that underpin its competitive advantage," Chief Executive Andrew Mackenzie said in a statement. |
The new organization will be headed by BHP's present CFO Graham Kerr and will be based in Perth. Dwindle Beaven, who currently runs BHP's copper business, will take over from Mr. Kerr as CFO. |
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