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Al-Megrahi died of cancer in Tripoli in 2012 and is the only person to be convicted over the 1988 atrocity. |
Mr Henderson is survived by wife Yvette, 75, their three children, Lissette, Vicky and David, and six grandchildren. |
Mrs Henderson said: “We were married for 51 years and he was a good father and a good husband. He was also very dedicated to the job he did, sometimes beyond the call of duty. |
A DAD-of-two died after falling into a hot vat of sulphuric acid in front of horrified colleagues on Saturday. |
Steelworker Daniel Hill, 54, suffered horrific burns to his entire body in the "serious industrial accident" at a metal manufacturing plant in South Lyon, Michigan. |
Panicked workers rushed to pull him from the 12 per cent strength solution - which was also heated to a searing 70C. |
Fire Chief Robert Vogel told the Detroit News: "He was completely submerged and was 100 percent covered in burns. |
"The gentleman was trying to get out. |
"They ran and grabbed him and pulled him out." |
Medics and police rushed to the Michigan Seamless Tube factory at 12:21pm on Saturday while co-workers tried to treat Daniel's burns by putting him under a safety shower. |
He was still able to walk and talk as he was rushed to the nearby University Hospital in Ann Arbor. |
But he tragically died from complications related to his harrowing "100 per cent" burns after docs battled for 11 hours to try to save him. |
Chief Vogel added: "Unfortunately, he passed. It was pretty extreme burns." |
It is unclear how Mr Hill ended up in the vat - or how long he was submerged before brave colleagues pulled him out. |
Stunned neighbour Stephen Kobylarz said Mr Hill and his family had just moved to the house they built in July last year. |
Mr Kobylarz added: "They are just very nice people, quiet. |
"They just loved their new house and the countryside, the wildlife, the deer - they mentioned they'd seen a coyote. |
"They are just very, very nice people. It was really a shock when I heard about it." |
Mr Hill - known as "moose" to pals - was also a grandfather-of-two. |
A Michigan Seamless spokesman described him as a "valued employee" who had worked for the company since April 2017. |
A "comprehensive investigation" is being carried out by the firm - and it is co-operating with health and safety officials, the spokesman added. |
Sulphuric acid solution is used to cure metal in the production process. |
Crossovers and SUVs are the hottest segments of today's automotive landscape. While they're typically a bit more expensive than cars, they don't have to cost an arm and a leg. There are plenty of options with starting price tags well below $25,000. |
For that price, you can get a high-quality, capable, and roomy SUV with two rows of seating and room for five. If you need more passenger space, you’ll have to pay a bit more than $25,000 for a vehicle such as the highly ranked 2017 Kia Sorento ($25,600), as the only 3-row models for less than $25,000 score poorly in o... |
Take a look at the following slides to see a selection of SUVs that have low starting prices and hold positions in the top tier of their classes in our new car rankings. |
This list is based on U.S. News scores, which are updated constantly as new expert reviews and data become available, so the scores listed here may be slightly different from the ones listed on our site. |
The 2017 Honda CR-V is just about the perfect compact SUV. Not only does it have tons of flexible space inside for both passengers and cargo, but it also has great safety scores and excellent fuel economy. The base model features a 184-horsepower four-cylinder engine and a continuously variable automatic transmission. |
In our rankings of compact SUVs, the CR-V holds the top spot. It’s also the winner of both our 2017 Best Compact SUV for the Money and Best Compact SUV for Families awards. Its base price of $24,045 is a bit higher than some rivals, but its high predicted reliability score gives buyers confidence that the CR-V will rem... |
The terms SUV and great handling aren’t often spoken together, but the 2017 Mazda CX-5 is the exception. When it comes to handling, the CX-5 is untouchable, plus it has plenty of room inside, a high-quality interior, and good fuel economy. The CX-5 was redesigned for the 2017 model year. |
Power comes from a 2.5-liter four-cylinder engine, and a six-speed automatic is now included on all CX-5 models. The base model includes push-button start, a six-way manually adjustable driver’s seat, a pair of USB ports, Bluetooth connectivity, low-speed automatic emergency braking, and a 7-inch infotainment screen. |
The CX-5 is one of the top-rated vehicles in our rankings of compact SUVs. |
The 2017 Ford Escape is one of those vehicles that doesn’t excel in any one area, but taken as a total package, it’s a solid value with nimble handling, lots of options, sufficient performance, and updated designs inside and out. Prices start at $23,750 for the base Escape S trim. |
The 2017 Escape is one of the top-rated vehicles in our rankings of compact SUVs, plus it was a finalist for both our 2017 Best Compact SUV for the Money and 2017 Best Compact SUV for Families awards. The $23,750 Escape S base model comes with keyless entry, a rearview camera, and a voice-activated infotainment system.... |
Of the highly rated vehicles in our rankings of compact SUVs, the 2017 Hyundai Tucson is one of the most affordable. For $22,700, the Tucson provides a quiet cabin with roomy back seats and excellent safety ratings. The base model includes stain-resistant upholstery, a rearview camera, and a 5-inch touch-screen infotai... |
You can also stay under the $25,000 mark with the Tucson Eco model. At $24,150, the Eco comes with, among other things, a more efficient turbocharged engine, a seven-speed automatic transmission, fog lights, and LED running lights. |
The 2017 Tucson was a finalist for U.S. News & World Report’s 2017 Best Compact SUV for the Money and 2017 Best Compact SUV for Families awards. |
The Chevy Equinox has been completely redesigned for 2018, gaining a host of high-tech infotainment features as standard equipment. Every 2018 Chevrolet Equinox now features a touch-screen infotainment system that supports Apple CarPlay and Android Auto. A 4G LTE data connection is also included on all models. |
In our rankings of compact SUVs, the Equinox holds a spot in the top third. Keeping it from achieving a higher rating, however, is a weak base engine and headroom (with the optional sunroof) that can’t match that of rivals. Chevy has promised more powertrain offerings in the future, but they will likely push the price ... |
The 2017 GMC Terrain scores a spot in the top half of our rankings of compact SUVs on the strength of its top-notch predicted reliability, comfortable seats, and upscale interior design. Prices start at $24,070 for the SL base model, which is only available with front-wheel drive. |
Its standard engine is a 182-horsepower four-cylinder, which is adequate around town but runs out of oomph when you need power on the open road. Though there are a couple of surprises among its standard features, such as a 7-inch touch screen, its list of included equipment is shorter than those of competitors’ base mo... |
If you’re looking for a reasonably priced compact SUV that you plan to keep for a long time, the 2017 Kia Sportage should be on your radar. Not only does it hold a spot in the top third of our rankings of compact SUVs, but it also comes with a 10-year/100,000-mile powertrain warranty. |
The base Sportage LX carries a price tag of $23,200, which is one of the lowest among highly ranked compact SUVs. It’s one of the only compact SUVs that can be equipped with all-wheel drive (a $1,500 option) and remain under $25,000. |
The Sportage comes standard with a list of equipment that’s comparable to the standard features in most class rivals, but Kia also offers a couple of option packages on the base model that include features such as a power-adjustable driver’s seat, dual-zone automatic climate control, and support for Apple CarPlay and A... |
The base model of the 2018 Subaru Forester doesn’t come with a long list of standard equipment, but there is one thing that it includes that separates it from class rivals. Every Forester comes with all-wheel drive. It’s also one of the few that comes standard with a manual transmission. |
In our rankings of compact SUVs, the Forester scores a slot in the top half. Despite the inclusion of all-wheel drive, at $22,795 it has one of the least expensive base prices in the class. Its boxy, utilitarian shape gives it excellent cargo and passenger space. Staying with the base engine earns drivers good fuel eff... |
The 2017 Honda HR-V scores with buyers due to its spacious interior and the variety of its cargo-hauling configurations. It currently holds the top spot in our rankings of subcompact SUVs and won both our 2017 Best Subcompact SUV for the Money and 2017 Best Subcompact SUV for Families awards. |
With a base price of $19,465, you can opt for even the highest-trim EX-L Navi model and stay below a $25,000 budget, though an EX-L Navi with all-wheel drive will push you over $25K. |
Standard features on the HR-V include a multi-angle rearview camera, Bluetooth, remote keyless entry, and a speed-sensitive volume control for the audio system that continuously adjusts to overcome any engine or road noise. |
Like its big brother, the Mazda CX-5, the 2017 Mazda CX-3 dominates its class when it comes to handling. With prowess that puts many cars to shame, the small crossover scores a spot near the top of our rankings of subcompact SUVs. CX-3 prices start from $19,960. |
Despite its relatively low base price, the CX-3 comes with a generous amount of standard equipment, including push-button start, a 7-inch touch-screen infotainment display, a six-speaker audio system, Bluetooth connectivity, and a rearview camera. |
For $24,990, you can get a loaded CX-3 Grand Touring with every feature offered on the SUV except all-wheel drive and the i-Activesense suite of high-tech safety gear. Those options add $1,250 and $1,170 to the price, respectively. |
Buick refreshed the Encore for 2017, giving it a new look and adding to its generous array of standard features. The 2017 Buick Encore is one of the top-rated vehicles in our rankings of subcompact SUVs and was a finalist for our 2017 Best Subcompact SUV for Families award. |
The Encore bridges the gap between mainstream and luxury models with its upscale interior and standard features such as support for Apple CarPlay and Android Auto on all models. An 8-inch touch-screen infotainment system, active noise cancellation, and push-button start all come standard as well. |
When it comes to predicted reliability, the Encore is untouched by any class rivals. |
The 2017 Jeep Renegade can’t match the fuel economy and standard feature list of many rivals, but when the pavement ends, it will, quite literally, leave them all in the dust. Upgrade from the $17,995 Sport base model to the $21,495 Latitude, and the equipment list is more competitive. |
The Renegade scores a spot in the top tier of our rankings of subcompact SUVs. It was a finalist for both our 2017 Best Subcompact SUV for Families and 2017 Best Subcompact SUV for the Money honors. |
While $25,000 isn’t quite enough to get you into the most off-road-capable model, the Trailhawk, any Renegade can hold its own in inclement weather when equipped with the $2,000 all-wheel-drive option. |
If you think that great fuel economy and SUVs don’t mix, you should take a look at the 2017 Kia Niro. Though some might think that it doesn’t qualify as an SUV because it lacks an all-wheel drive option, it features the space and higher ride height that SUV buyers desire. |
You can purchase either the all-new Kia Niro FE or LX and stay below $25,000. The base model earns EPA fuel economy estimates of 52 mpg in the city and 49 on the highway. To get the top-notch fuel economy estimates, however, you have to stick with the Niro's lower trims. Due to equipment differences and larger tire and... |
The Niro currently holds a spot in about the middle of the pack of our rankings of subcompact SUVs. |
Finding an SUV for less than $25,000 is a great deal, but you can do even better by employing a couple of tools from U.S. News & World Report. Our Best Price Program saves buyers an average of $3,279 off MSRP by working with local dealers to provide guaranteed savings. |
Theobald Stapleton was born in Co. Kilkenny, Ireland, but was English by descent, though not connected with the Yorkshire Stapletons. Nothing is known of his career, except that he was a priest living in Flanders, and that in 1639 he published at Brussels a book called "Catechismus seu doctrina christiana latino-hibern... |
And so we embark on a new era of healthcare—one that may take many years to fully reach its potential for good or ill. But there are two small bits in the Patient Protection and Affordable Care Act that are immediately relevant and timely for the biotechnology industry. One provides tax breaks for smaller biotechnology... |
The Therapeutic Discovery Project Credit provides “an amount equal to 50 percent of the qualified investment for such taxable year with respect to any qualifying therapeutic discovery project,” permitting some of the costs for pre-clinical research, clinical trials and other research protocols to be reduced. It appears... |
A billion dollars is not chump change but could disappear pretty rapidly when clinical trials are included. This credit will be helpful for the right companies but it seems to be a one-time shot in the arm. |
The noteworthy part of the legislation, Approval Pathway For Biosimilar Biological Products, provides real clarity on an important regulatory issue. This section permits biologics—the complex therapeutics produced by most biotechnology companies—to maintain 12 years of market exclusivity after FDA approval of the produ... |
The biotechnology industry breathed a sigh of relief with this section’s passage because this clearly delineated time frame could have been much different. |
The Federal Trade Commission had felt that no additional period of exclusivity was required. The Generic Pharmaceutical Association (GPhA) wanted only a five year period. President Obama wanted seven years. The Biotechnology Industry Organization (BIO) wanted at least 12 years. In the end, BIO got exactly what it wante... |
This uncertainty has been eliminated. Biotechnology companies now have a known period of market exclusivity post-approval, one that is independent of patent time frames. This will provide investors with the predictability they crave when they project product sales far into the future for biotech drugs in development. |
Near-term I believe biotech got what it wanted. But, as long as proprietary biologics remain expensive you can not underestimate the financial incentives for encouraging and helping follow-on biologics gain market approval. Hatch-Waxman demonstrated this and the ability for Congress to change its mind, like when the co... |
Richard—one thing I forgot to ask yesterday. What kind of impact will biotech feel from having millions of more Americans with health insurance? Doesn’t this mean that the potential customer base for expensive brand-name biologic drugs just got a lot bigger? |
I think the complexity of the legislation makes it hard to know just what will happen with drug pricing so, as a possible patient, I hope you are right and that follow-on biologics will drive the price of biotech drugs down. |
It is likely that the complexity of developing these drugs, and then manufacturing them, will make it difficult to offer them for a substantial savings. |
Some projections have them only being able to come in with a 20-30% reduction in the price of the biosimilar. This may not be enough of a price difference for most drugs to provide much of a competitive advantage. |
A biosimilar may not then have enough of a price break to effectively compete with a biologic that has been on the market for 12 years. |
Of course, it is not outside the realm of possibility that Congress will attack the problem of high drug costs with future legislation. |
That will be another, possibly less optimistic, story. |
Having millions of new people who might get access to the drugs is an obvious gain. |
A nagging question with all of this is whether there will be any change in the prescription rates for their drugs. |
For example, I have a friend with RA. The insurance company will only pay for her to get Enbrel if she fails in a response to methotrexate. |
My understanding is that there is no real medical reason for this but it is purely economic. Methotrexate costs pennies while Enbrel costs thousands. |
I don’t think Healthcare Reform is going to alter that equation. |
If it could, there would be a revolutionary change in the fortunes of many biotech companies. |
I think the effect the current legislation has on the prescription rates for biotechs will be more evolutionary rather than revolutionary. |
If the “public option” had been signed into law, you can bet there would have been howls of protest from the biotech industry. That would have given the federal government significantly more bulk-purchasing power than it already has, allowing it to negotiate for even steeper discounts. |
The Congress has been very careful to prevent the government from being able to set prices that way. The Medicare drug benefit passed during the Bush Adminstration made sure the US could not really negotiate lower prices. |
I just do not ever see that happening without some real changes in drug pricing worldwide. |
What I have always heard is that the US really subsidizes the lower prices in many countries by paying more. If we want to lower the prices significantly in the US, it might be necessary for new higher prices to be negotiated worldwide. |
The commentators keep reminding us that Theodore Roosevelt was the first president who tried to bring universal health care to the American people. That’s not quite true. He never really expressed the idea while he was in office. In 1912 Roosevelt had been out of office for four years when he attempted to reclaim the p... |
A generation later TR’s distant cousin Franklin attempted to pick up the torch of universal health care. In his 1944 State of the Union address, he told the American people that his major goal for the post war world was national health insurance. Unfortunately for you and I, FDR did not live to see the war’s end. A fil... |
The new health care bill is not perfect – far from it – but as the old Chinese saying goes, “The journey of a thousand miles begins with the first step.” There will be improvements made on it down the years – there absolutely needs to be – but this is a fairly good first step. We’re on our way! The Conservatives will w... |
Do you know if the new biosimilars legislation applies equally to biologics already on the market as it will to newly approved biologics? I can’t seem to find any mention of this and am trying to figure out what the first biologic to use the new abbreviated pathway will be. |
I’d appreciate your thoughts on the matter. |
I wondered about that also. I think that it applies to any biologic that has been approved by the FDA, even ones in the past. They each get a total of 12 years of market exclusivity from the date of approval. Thus the ones on the market today will have less than 12 more years. |
I believe that the EU has had a pathway for follow-on biologics. As I recall, some of the first were recombinant insulin therapeutics. Maybe we will see the same here. |
Thanks Richard for the response. That was what I was thinking as well, but had trouble following the language in the bill. I think that generic epo was one of the first products approved in Europe as a biosimilar, I had thought that the recombinant insulins had used a different regulatory pathway…but that’s not really ... |
No one here seems to be familiar with “Medicaid”, the form of health insurance which Obamacare will be patterned after. |
Before you spend too much time with those dollar signs in your eyes, you had better inform yourselves as to just what is going to happen. |
There is no excuse for uninformed expectations with so much riding on the outcome. |
The new health care reform law also includes another provision likely of interest to early stage companies — the CURES Accelerator Network. The new law creates a $500 million fund to support research and product development activities for “high need cures”, defined as diseases or conditions for which there is little co... |
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