text stringlengths 13 81.7k |
|---|
The new agreement, still sub ject to approval by stockhold ers of both companies, calls for an exchange of eight shares of Volt common stock for one share of Teleprompter common. Original terms, announced last Oct. 13, called for an exchange of one share of Teleprompter common and one share of a new class of preferred ... |
TOKYO and WOBURN, Massachusetts, January 12, 2011 /PRNewswire/ -- Daiichi Sankyo Company, Limited (TSE 4568) and ArQule, Inc. today announced that the first patient has been enrolled in the phase III trial of ARQ 197, an investigational selective inhibitor of the c-Met receptor tyrosine kinase, in combination with erlo... |
The phase III trial is a randomised, double-blinded, controlled study of previously treated patients with locally advanced or metastatic, non-squamous NSCLC who will receive ARQ 197 plus erlotinib or placebo plus erlotinib. |
The primary objective is to evaluate the overall survival (OS) in the intent-to-treat (ITT) population. Secondary endpoints include OS in the subpopulation of patients with epidermal growth factor receptor (EGFR) wild type, progression-free survival (PFS) in the ITT population, and further assessment of the safety of A... |
According to the International Agency for Research on Cancer, more than 1.6 million new cases of lung cancer were diagnosed in 2008 globally, and NSCLC accounted for 80 percent of those cases. According to the American Cancer Society more than 220,000 cases of lung cancer will have been diagnosed in 2010 in the U.S. Of... |
"With lung cancer accounting for more deaths than colon, breast and prostate cancers combined, we are very pleased to begin this phase III trial to advance the knowledge about the role ARQ 197 might have in the treatment of patients with non-small cell lung cancer in combination with erlotinib," said Dr. Kazunori Hirok... |
"The start of this phase III trial marks a key milestone in the development of ARQ 197 and our partnership with Daiichi Sankyo," said Paolo Pucci, chief executive officer of ArQule. "Lung cancer is a devastating disease, and our hope is that ARQ 197 will prove to be an effective treatment option that will help patients... |
In October 2010, agreement was reached with the U.S. Food and Drug Administration (FDA) on a Special Protocol Assessment (SPA) for the phase III trial comparing ARQ 197 plus erlotinib against erlotinib plus placebo. The phase III study of ARQ 197 plus erlotinib will enroll 988 patients in 150 sites in the U.S., Canada,... |
FREDERICK, Md. - A Frederick City Police officer was hurt Monday night after an altercation with a man he was escorting back to police headquarters for questioning, according to police and court records. |
Detective 1st Class Michael D. Beattie's nose was injured, but he did not require medical attention, according to court records. He bled extensively, court papers said. |
Beattie's pants were torn and his shirt, jacket and tie were bloodied and his contact lens were destroyed, according to court records. In addition, he lost a tie clasp and his leather portfolio and belt were damaged, according to court papers. The total value of the items was placed at $440. |
Brett Adam McMurry, 21, of no fixed address, was charged with four counts of destruction of property, drinking in public, second-degree assault, attempting to disarm a police officer, reckless endangerment, resisting arrest and giving a false name to police. |
McMurry is being held on $80,000 bond in the Frederick County Adult Detention Center. |
The incident began when Beattie saw fresh graffiti on an elevator of a parking garage on Court Street, police said. He also saw graffiti in the stairway on the first level and between the fourth and fifth levels, police said. |
On the top level, Beattie saw four people, who told him a person named "James" was responsible for the vandalism, according to court records. Beattie asked them to follow him back to the police station. When Beattie initially approached the group, one man was allegedly drinking a Milwaukee's Best beer from a can inside... |
The man, who was walking in front of Beattie, allegedly turned around and punched him in the face. Beattie went backwards, tripped over a bench and the suspect allegedly jumped on top of him and continued striking him in the face. |
Beattie managed to stand up and radio for backup when the suspect allegedly attacked him again, court records said. The suspect allegedly then grabbed the officer from behind and reached in the area of his gun, court documents said. |
When another officer arrived on the scene, the attacker allegedly tried to flee but was caught in the courtyard, court records said. |
The officer used pepper spray to subdue the suspect, according to court papers. In an attempt to get away, he fell over a wall into a lower courtyard area, court records said. After the attacker was arrested, he allegedly gave a fake name to police. |
Police are searching for another member of the group, who allegedly fled the scene during the altercation. A warrant has been issued for John David King, 18, of the first block of West 5th Street in Frederick. He is wanted on charges of destruction of property and escape from confinement, police said. |
The State of the Union is on Tuesday, Feb. 5. On the latest edition of the Politically Georgia podcast, your Political Insiders identify what to watch for from Georgia politicians. |
President Donald Trump will be delivering the State of the Union address on Feb. 5. |
With Stacey Abrams set to deliver the Democrat State of the Union response, select Democrats planning to boycott and Republican lawmakers to keep an eye on, there will be plenty for you to watch on Tuesday. |
Host Greg Bluestein and the AJC’s Washington correspondent Tamar Hallerman break down what to know about the upcoming event and what to watch from Georgia politicians. |
State of the Union 2019: Who are the president’s guests? |
The hearing before the House Homeland Security Subcommittee on Emerging Threats, Cybersecurity and Science and Technology was prompted by a simulation that highlighted vulnerabilities in the computers that run water, power and chemical plants. In the March Aurora Generator test, researchers from the Idaho National Labo... |
"If this administration doesn't recognize and prioritize these problems soon, the future is not going to be pretty," said Rep. Jim Langevin, D-R.I., chairman of the subcommittee. |
The government and industry experts who testified cited flaws in regulations set by the North American Electric Reliability Corporation. Certified as the electric reliability organization by the Federal Energy Regulatory Commission on July 20, 2006, NERC is charged with improving the reliability and security of the bul... |
"NERC reliability standards [are] less stringent guidelines than [those offered in the] NIST guidance," said Greg Wilshusen, director of information security issues at the Government Accountability Office. "They do not provide the level of standard, mandatory protection required." |
Specifically, NERC standards focus on the bulk power system as a whole, but don't properly address the threat of regional outages or the security of the IT components that support the electric grid, Langevin said. By contrast, the System Protection Profile for Industrial Control Systems developed by NIST in collaborati... |
"Why [NERC] would have standards below NIST is beyond me," Langevin said. "This is something we're going to [pay] close attention to; perhaps legislation will be required." |
DHS has been collaborating with electric companies to improve security measures, and the Federal Energy Regulatory Commission released standards in July 2007 that would further guard systems by mandating the creation of security plans and controls. But testimony from Greg Garcia, assistant secretary of the Office of Cy... |
"We rely on the industry sector leads to collect information on the percentage of industry that has implemented … recommendations," Garcia said, when asked about industry adoption of improved processes. He suggested that the subcommittee ask FERC for more comment. |
Langevin said Homeland Security should be "more proactive to make sure that [recommended standards] are actually implemented." |
Not one, but two of the most anticipated Russian big screen premieres this year are about ballet: Valery Todorovsky’s “Bolshoi” and Alexei Uchitel’s much discussed “Matilda.” The former, directed by Valery Todorovsky, hits theaters nationwide on May 11 and it’s a film not to miss. Todorovsky is best known for his 2008 ... |
“Bolshoi” was conceived several years ago and took a long time to produce. In Todorovsky’s own words, he’s never been a fan of ballet, but one day at a performance he realized that the dance form was “very attractive” for him as a cinematographer. |
is a whole world. And I wanted to enter that world and tell a story about it,” says Todorovsky. |
The movie centers on two characters, Yulya and Karina, who study at the ballet academy and then compete to become lead dancers in a performance at the Bolshoi Theater. |
“Bolshoi,” Valery Todorovsky’s new movie on Russia’s most famous ballet, secured access to the illustrious theatre for filming. The movie opens nationwide on May 11. |
“It’s a two hour long novel about the people who come into the world of ballet a for a chance to stand for 10 minutes on that stage. People are prepared to die for it,” says Todorovsky. |
The original cut of “Bolshoi” was actually three and a half hours long. Todorovsky hopes that after the film’s theatrical release he will have a chance to make it into a TV series. |
Even though several acclaimed actors are involved in the movie, including Alisa Freindlikh and Valentina Telichkina, who play instructors at the Ballet Academy, both main characters are played by newcomers, discovered in the world of ballet. Todorovsky says it was the most difficult casting process he’s taken part in. |
Todorovsky and his team went to pretty much every ballet theater in Russia and some of the former Soviet Union countries scouting for the right balance of ballet and acting skills. |
Margarita Simonova, who plays Yulya, was found at a theater in Warsaw (Poland), while Anna Isayeva, who plays Karina, was at a dance school in Moscow. Andrei Sorokin, who was cast for the role of Mitya, the girls’ mutual love interest, is a principal dancer at the Yekaterinburg Theater of Opera and Ballet. |
“The trick was to find young actors, who would look similar to play our main characters as children,” says Todorovsky, explain- ing that they were discovered not in the ballet, but at gymnastics schools. |
Another aspect that makes “Bolshoi” all the more interesting to watch is that all the scenes that take place inside the world- famous theater were really filmed there, a privilege that not many filmmakers enjoyed in the past. On the other hand, the ballet academy is a replica built at a film studio because filming on l... |
Todorovsky says that the filming process was “a gradual, step by step immersion [into the world of ballet].” “And now that the movie is done, I can say that yes, I love ballet,” he adds. |
Former West Indies Women’s captain, Merissa Aguilleira. |
PORT OF SPAIN, Trinidad, CMC – Former West Indies Women’s captain, Merissa Aguilleira, said she was “a bit saddened” by the sacking of the entire management unit following the recent failed Women’s World Cup campaign, but says she is excited by the prospect of working with the new interim management team. |
Head coach Vasbert Drakes, assistant coaches Ezra Moseley and Stuart Williams along with operations manager Ann Browne-John were all shown the door by Cricket West Indies, after presiding over a wretched run at the showpiece in England last July. |
In a complete overhaul, physiotherapist Oba Gulston, fitness coordinator Hector Martinez-Charles, performance advisor Donald La Guerre and analyst Trent Sargeant, were also replaced. |
“I was a bit saddened by it. He (Drakes) has been a good coach. He had been with us for a little while now,” Aguilleira, a veteran of the squad with 103 One-Day Internationals and 81 Twenty20 Internationals, told CNC 3 Television here. |
“He came in for the Sri Lanka tour 2015 and he did a good job from start to end so it’s probably a decision that was taken just looking at the future of the women’s team. |
West Indies Women arrived at the World Cup as one of the favourites, having won the T20 World Cup last year and reached the final of the last 50-overs World Cup. |
But they endured a dismal run of form, losing all their warm-up matches before also slipping to defeat in their opening four tournament matches, to suffer early elimination from the semi-finals. |
Aguilleira said the management team, though, had gelled well with the squad and players had benefitted as a result of their expertise. |
“The entire management staff have been really good to us. All the players would’ve definitely learned something from them, from the manager straight back,” she pointed out. |
“We even had the assistant batting coach Stuart Williams coming in with us and he did a tremendous job. We had Ezra Moseley our assistant coach, the trainer Hector, our analyst Trent, the physio Oba and also the manager. |
With a series against touring Sri Lanka Women starting next month, Aguilleira said it was important the side were not distracted by the changes. |
“The CWI will have a valid reason for it (the change), I’m not going against it,” the 31-year-old stressed. |
“Certain times you are in a different situation so you don’t know exactly what angle they’re looking from but at the end of the day, as players our main focus is just to focus on our job at hand. |
Head coach Henderson Springer will lead an interim management unit which also includes former Bermuda and West Indies head coach, Gus Logie, as his assistant. |
And Aguilleira hailed the competence of the incoming personnel, pointing out they were all excellent choices. |
“When you think about the head coach which is Mr Henderson Springer. He has been with the Barbados women’s team [and] I’ve done a couple of training [sessions] with him,” the Trinidadian said. |
“He’s a great coach, you can’t fault him on that. He’s an excellent coach. I’m really looking forward to working with him. Even Gus Logie … these are coaches that have interacted with women so they understand and we can be a handful when we’re ready but at the end of the day, they understand how to deal with women. |
Despite the sacking of the management unit, the entire World Cup squad was retained for a training camp starting later this month in Trinidad, from which the sqaud to face Sri Lanka will be selected. |
PORTLAND endured highs and lows in season 2018. The Tigers’ senior football side started with a bang, winning four of its first five matches. But it only added two more victories – the final two games of the season – to finish second bottom on the Hampden league ladder. Coach Luke Crane announced he would step aside fr... |
PORTLAND endured highs and lows in season 2018. |
The Tigers’ senior football side started with a bang, winning four of its first five matches. |
But it only added two more victories – the final two games of the season – to finish second bottom on the Hampden league ladder. |
Coach Luke Crane announced he would step aside from the top role after fours seasons. |
Portland also battled through a tough campaign on the netball court. |
The Tigers’ open side collected the wooden spoon after finishing on the bottom on percentage with just two wins. |
Ad-tech firm Rubicon Project on Monday announced that David Day will be its CFO, and Khoi Nguyen was named vice president, product management for video, a newly created role. The appointments come on the heels of last week’s news of seven high-level departures including the company’s president, Greg Raifman. The new ap... |
Day has served as Rubicon Project’s interim CFO since May 2016 and the company’s chief accounting officer since joining the firm in March 2013. As CFO, Day is tasked with overseeing all finance functions, including financial reporting, treasury, tax, audit, and investor relations. He reports directly to Rubicon Project... |
Previously, Day was chief accounting officer at ReachLocal, a publicly traded digital advertising company, and SVP of finance at Overture and at Yahoo Search Marketing. |
Nguyen, who formerly worked at OpenX and Google, will lead video advertising at Rubicon Project. The company said it's prioritizing video as it refocuses its business, noting that more than half of the company’s top 100 customers use its technology to run their video advertising business. The number of Rubicon's video ... |
People's lives could be put at risk because thieves are cutting gas pipes as they strip metal from homes and businesses around Norwich, police have warned. |
Police have seen a surge in the number of metal thefts around the city in the past five months, with a particular spate during April and May, which could be linked to a hike in the prices of metal. |
Three people have been arrested, but theives continue to target the west centre, city centre and Mile Cross, Catton and Fiddlewood areas of Norwich, police said. |
The criminals have targeted businesses, as well as people's homes, making off with copper and lead. |
But police said the criminals could also be putting people's lives at risk because in some cases they have cut gas pipes, creating a safety risk and affecting central heating and air conditioning. |
Lead flashing has also been removed from the outside of houses. |
Inspector Nigel Richards, from the police's west centre safer neighbourhood team, said: “We are putting the recent rise down to the fact that metal prices have risen. |
Mile Cross, Catton and Fiddlewood safer neighbourhood team sergeant Anthony Abigail said: “In our area thieves have been targeting abandoned factory units where thousands of pounds worth of metal has been stolen. |
The Evening News reported last month how church leaders had called on people in the city to keep a look out for thieves looking to strip lead from historic buildings. |
The plea cames as it emerged St George's Church in Colegate had lead ripped from its roof between 6pm on Wednesday, April 28 and 6pm on Thursday April 29. |
And in 2007 damage caused when lead was stolen from the St Andrew's Church in Trowse led to water pouring the the roof, ruining the church organ and tearing through plaster on one of the walls. |
Anyone with information about scrap metal thefts or anyone who spots somebody acting suspiciously should contact Norfolk police on 0845 456 4567 or Crimestoppers on 0800 555111. |
Published: Aug. 24, 2014 at 09:34 a.m. |
Updated: Aug. 24, 2014 at 10:16 a.m. |
Their defense is a wide-open barn door, but the Dallas Cowboys have shown promise along their young offensive line. |
A bright spot during the team's first two preseason tilts, the front five struggled in Saturday night's 25-20 loss to the Miami Dolphins. |
The first-string wave of Tyron Smith, Ronald Leary, Travis Frederick, Zack Martin and Doug Free weren't able to shield a post-surgery Tony Romo from three first-half sacks on a night that saw the 34-year-old passer finish 10 of 18 for just 87 yards. |
"That concerned me," team owner and general manager Jerry Jones said, per The Dallas Morning News. "Not because of being able to correct what it takes to block them, but it just concerned me that he was taking those sacks." |
Said Jones of his line: "They're a strength, but it shows that they've got some more work to do." |
If you're searching for a silver lining, it's a positive that Romo and his surgically repaired back bounced right up after each attack. Starters rarely see the field in the preseason's fourth and final week, but Jones suggested the first-team offense might play against the Broncos on Thursday. |
"I don't know that would include Romo," said Jones, "but I think we might be able to see more work -- speculation, but I haven't talked to the coaches about this and it will be their decision -- but that offensive line might get some work against Denver." |
EA has announced that preregistration for EA Play starts Tuesday, March 27. The three-day event takes place June 9-11 at the Hollywood Palladium in Los Angeles and leads into the official start of E3 2018 (June 12-14). |
Fill out the preregistration form between now and May 25. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.