Split (1)

train · 2.59M rows

text stringlengths 9 93k
All the serials look alike nowadays. Some have tried to change the trend but television is no longer interesting. There are only a few good shows like Balika Badhu and FIR.
I don't want to get involved in daily soaps. I did Chacha Chaudhary for two-three years but realised that I cannot do the same characters for too long.
CAMBRIDGE, Mass., Feb. 27, 2015 (GLOBE NEWSWIRE) -- SAGE Therapeutics (Nasdaq:SAGE), a clinical-stage biopharmaceutical company developing novel medicines to treat life-threatening, rare central nervous system (CNS) disorders, today reported business highlights and financial results for the fourth quarter and full year...
"SAGE had a remarkable year in 2014 with the achievement of several clinical and corporate milestones, including significant progress in the development of our lead molecule, SAGE-547, successful completion of our initial public offering, and essential additions to our leadership team and board," said Jeff Jonas, M.D.,...
"Looking ahead, 2015 will be a year rich with milestones. We expect to report final results from our ongoing Phase 1/2 trial of SAGE-547 before initiating a registration trial by mid-year. We are on track to report proof of principle data from exploratory Phase 2a studies of SAGE-547 in essential tremor and severe post...
Phase 1/2 Trial of SAGE-547 in Super-Refractory Status Epilepticus (SRSE) Continues to Enroll: The Phase 1/2 open-label trial is continuing to enroll patients in an expansion cohort under a protocol amendment, allowing treatment of pediatric patients as young as two years old and enabling increased dosing of SAGE-547. ...
Earlier this year, SAGE reported updated data from the Phase 1/2 trial of SAGE-547 as an adjunctive therapy for the treatment of SRSE, a critical condition in which the brain is in a state of persistent seizure, where patients are placed in a medically induced coma in an attempt to stabilize them, and where conventiona...
SAGE-547 Emergency-Use Program Consistent with Clinical Activity and Safety Profile: Earlier this year, SAGE reported that ten patients have been treated with SAGE-547 by independent centers under emergency use Investigational New Drug applications. Seven of nine evaluable patients treated with SAGE-547 achieved resolu...
Exploratory Phase 2a Trials of SAGE-547 Continue to Enroll: SAGE is using SAGE-547 to establish proof of principle in clinical trials for additional CNS disorders, including essential tremor and severe postpartum depression. These trials are designed to evaluate the safety, tolerability, pharmacokinetics and activity o...
Advancing Portfolio of Proprietary Molecules: SAGE continues to advance its pipeline of second-generation molecules. SAGE-217 is being developed as an oral therapy for orphan genetic epilepsies, and SAGE-689 is being developed as an adjunctive intravenous second-line therapy for the treatment of refractory status epile...
Cash Position: Cash and cash equivalents as of December 31, 2014 were $127.8 million, compared with $8.1 million at December 31, 2013. The increase was primarily due to net proceeds of $94.0 million from the company's initial public offering completed in July 2014, partially offset by cash used to fund its operations.
R&D Expenses: Research and development expenses were $8.9 million in the fourth quarter of 2014 and $24.1 million for the year ended December 31, 2014, compared to $4.5 million and $14.4 million in the comparable periods in 2013. The increase in R&D expense was primarily due to increased spending on clinical activities...
G&A Expenses: General and administrative expenses were $3.4 million in the fourth quarter of 2014 and $9.7 million in the year ended December 31, 2014, compared to $1.2 million and $3.9 million in the comparable periods in 2013. The increase in G&A expenses was largely due to personnel-related costs and professional fe...
Net Loss: Net loss was $12.4 million for the fourth quarter and $33.8 million for the year ended December 31, 2014, compared to net loss of $5.7 million and $18.3 million for the comparable periods of 2013.
SAGE-547 is an allosteric modulator of both synaptic and extra-synaptic GABAA receptors. GABAA receptors are widely regarded as validated drug targets for a variety of disorders, with decades of research and multiple approved drugs targeting these receptor systems. SAGE-547 is an intravenous agent in Phase 1/2 clinical...
SAGE Therapeutics is a clinical-stage biopharmaceutical company committed to developing and commercializing novel medicines to treat life-threatening, rare central nervous system, or CNS, disorders. SAGE's lead program, SAGE-547, is in clinical development for super-refractory status epilepticus (SRSE) and is the first...
This release contains forward-looking statements and information. The use of words such as "may," "might," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "potential," or "continue," and other similar expressions are intended to identify forward looking statements...
Tidy towns, Germany’s election and ‘Take the Knee’ protests had people talking today.
Birdhill in Co Tipperary was crowned Ireland’s tidiest town for 2017.
#TAKE THE KNEE: A wave of protests swept across the American football industry as President Trump escalated his feud with players who kneel during their national anthem.
#GERMANY: The nationalist AfD party was hit by infighting just hours after winning its first seats in parliament, with its co-chief Frauke Petry walking out.
Noel Gallagher told a great story about meeting President Michael D Higgins at Bono’s house over the summer (he was hungover at the time, unsurprisingly).
Here’s a snippet of the take, via the DailyEdge.ie.
[Bono] said, “Look, the President of Ireland’s just arrived and you’re sitting next to him, so hurry up.” So I had to get showered, get up there, ‘whey, ey’, and all that.
The lunch started at three. Do you know what time it finished? Ten past four in the morning.
Comments have been closed as a case is due before the courts.
It’s a pathology of this presidency that continues to go under-examined: Donald Trump simply does not recognize that his role as president confers on him any institutional obligation toward the American people of any kind.
This is the through line that runs through the biggest stories of the moment: Trump’s demonization of Rep. Ilhan Omar; his unhinged policies and lawlessness toward the humanitarian crisis at the border; and his effort to prevent the voters from gaining a full accounting of his finances, and, by extension, of his corrup...
That through line also explains the need for his survival strategy over the long term, which rests on a backup plan that banks on salvation at the hands of the electoral college, or the courts, or perhaps both.
Trump’s disregard of the institutional obligations attendant to his role as president is the subject of a good piece by Peter Baker of the New York Times, who frames the point in a more restrained way. As Baker notes, Trump’s latest actions demonstrate that he’s dispensed with even the “pretense” of pretending to be “t...
Trump has repeatedly called Democrats “treasonous” and has threatened to dump migrants into their districts (as someone remarked on Twitter, it’s as if they are bearing smallpox blankets), because they won’t give him the changes to immigration law he wants.
What’s more, even as Trump is ostensibly demanding that Democrats engage with him constructively on the asylum crisis — he just tweeted as much again — he is threatening to shut down the border and is reportedly pressuring officials to break the law by banning asylum seekers entirely.
This idea — that Democrats can be bulldozed into doing his bidding even as he carries out an unchecked, destructive and lawless rampage — is itself a display of deep, seething contempt for the opposition party and its voters.
His social media advertising is aimed disproportionately at older Americans who were the superstructure of his victory in the Electoral College in 2016. His messaging is permeated with divisive language that galvanizes core supporters more than it persuades anyone on the fence, much less on the other side.
That social media advertising aimed at older voters heavily emphasizes nativist themes. And indeed, the key to all this is how that plays into the electoral college.
Even some Republicans admit to this. Several of them recently told the Washington Examiner that they fully expect Trump to lose the popular vote but are banking on him winning via the electoral college.
An electoral college win is a win, of course, but what’s notable about all this is that, in Trump’s apparent view (whether by instinct or design is hard to say), it requires telegraphing to his base that he’s essentially not functioning as president for other groups.
On display here again is Trump’s utter refusal to accept any institutional obligation to use his bully pulpit to calm his supporters down about Omar, if only to reassure U.S. Muslims. We saw the same after the Charlottesville violence: Trump refused to unambiguously condemn white supremacy, disregarding any obligation ...
Again and again and again, reporting has confirmed that Trump has conceived of his most widely hated and polarizing policies as gestures his base will love, whether it’s the horrific family separations, pardoning racist Joe Arpaio or attacking African American football players.
Trump would perhaps prefer to win a popular majority outright — and he still very well might — but it’s obvious the campaign sees an electoral college win amid a popular-vote loss as its most likely path to victory. As Joshua Green and Sahil Kapur report, such a win runs through incredibly juiced-up energy among non-co...
He is particularly angry about the efforts by the Ways and Means Committee to obtain his tax returns, telling aides he will fight that demand all the way to the Supreme Court and adding that, by then, the 2020 election will be over.
The case for getting Trump’s tax returns should be a legal slam dunk, but Trump’s allies have not even remotely given up on the possibility that the Supreme Court could rule that the law empowering Congress to do this is unconstitutional. Trump is either hoping for that, or hoping the courts string this along until aft...
Once again, what’s crucial here is that Trump recognizes no institutional obligation of any kind to disclose his tax returns as a gesture of transparency to the American people that they are entitled to from their public officials — an obligation recognized by previous presidents for decades.
Similarly, it’s perfectly plausible that Trump’s handpicked attorney general, William P. Barr, could fight Democratic efforts to get the full Mueller report all the way to the Supreme Court. We don’t know if that’ll work, but at a minimum Trump is plainly betting that a sustained court battle will dissipate the ultimat...
Trump’s voters don’t care if those things never come to light. And that’s all that matters. Indeed, fighting the release of those things, it is said, will energize them. It’s often observed that Trump is a minority president. But it’s worse: Deliberately functioning as a minority president is itself the long-term survi...
David Byler: The Buttigieg Bump is real. But Mayor Pete still has a long way to go.
The Post’s View: Democratic candidates are releasing their tax returns. We still need Trump’s.
It is The Tico Times’ policy to conduct reviews anonymously. If we have reviewed your establishment and you disagree with our assessment, you are welcome to comment on the article, and if you wish, request a follow-up review.
Your definition of disaster may differ from mine. You may have fought in wars and been bombarded by incoming troops. But in my little parent world, this is what the word means: Pour eight people, ages 15 through 55, into an undersized van, take the scenic route to San Carlos, and listen to white hip-hop the whole way. ...
Actually, I love the rainy season. It is my favorite time of the year, which is a good thing because it lasts for months. On our way up to San Carlos, I tried to talk about how the lushness and happy birds and bees made this season special. I tried to explain how going to look at a beautiful young volcano (Arenal) woul...
My son actually rolled his eyes to the rest of the group, making it clear I wasn’t really his father.
But then a miracle happened. It’s called the Arenal Springs Hotel. We brought in our motley crew, found our reservations were booked ($130/night per room, including breakfast), and were immediately surrounded by bright professionalism. The surly group was escorted to their rooms, which turned out to be great. All boast...
The hotel’s concierge devotes himself to booking adventure trips. How he handled our people is beyond me, but they spent every day doing wonderful things, from canyon rappelling to ATV tours, all with rave reviews, all with pickup service at the hotel, and with nothing charged until the final bill. Suddenly the rain, t...
The food is more than fine. They boast two major restaurants, both of which we tried. One serves a decent buffet breakfast as well as lunch and dinner, and the other is an Italian pasta-pizza affair, with a large geological mockup of the volcano we couldn’t see, yet which I tried to explain to a sea of deaf ears.
The place is Tico, through and through. It isn’t a slice of Orlando scotch-taped in the middle of a foreign country. There is continental cuisine, and the facilities would be considered more than adequate anywhere in the world, but there’s no question about it: they make a mean gallo pinto. You’re in Costa Rica, unmist...
There are two special features we particularly adored. First, we older folks sat on our patio, watching the rain, while the kids did their activities. We were blessed by an array of exotic birds coming to eat the papayas out of the tree in our backyard. This provided endless entertainment to our lazy minds. Secondly, w...
This isn’t your $1000-per-night hotel. It is just a very nice place. We highly recommend it, and we would like to extend our sincerest gratitude to Mr. Minor Castro, general manager, for his phenomenal job training his staff, and for giving our group of castaways a fabulous vacation in paradise.
Thank you, Arenal Springs. Disaster averted.
Arenal Springs Hotel, www.hotelarenalsprings.com, 506-2479-1212, or from the U.S. or Canada 1-855-457-6029. Getting there: There at least three different routes you can take by car – from the Limón side (a tortuous drive through Sarapiquí), over the old road through Grecia, or from the Pacific through Cañas. You can al...
Dyson believes that by Wednesday his worries about his groin will have passed, and he’ll be able to run with less caution. By then, the tempest about Dyson’s perceived lack of hustle probably will have passed.
So if Jarrod Dyson was banged up and trying to play through it, but being cautious when he could, those of us who criticized him without knowing the full story owe him an apology.
If Dyson’s hurt, why not say so?
OK, so Jarrod hurts himself in Seattle, but it doesn’t come out until the following Tuesday; if Dyson’s hurt, why not say so?
Because it gives the opposition an advantage.
If I’m a pitcher and I think I have a healthy Jarrod Dyson standing on first base, I have to use all the tricks in the book to keep him from stealing second. I hold the ball in the set position, I attempt pickoffs, I throw more fastballs, I slide step, I might even throw a pitch out. I’m distracted by Jarrod’s presence...
If I know Dyson’s hurting, I don’t have to do any of that.
The media loves to write about injuries, lineup changes and roster moves. They’re easy stories that fit the definition of news, so we pursue them vigorously. It’s eventually going to backfire if people lie, but teams don’t always owe us the whole truth; a team should not give away an advantage because a reporter needs ...
Hang around a team long enough, develop enough relationships so people will tell you the truth (sometimes it has to be off the record) and you begin to understand just how much we don’t know.
A player gets picked off first base and is hammered by critics for being a dummy. Later you find out he got picked off because he was stealing signs and looked in the catcher’s direction just as the pitcher threw over to first base. The player doesn’t want that out there because A.) He doesn’t want to get drilled the n...
A player does not hustle down to second base and break up a double play; instead he peels out of the base path early. Later you find out his throwing shoulder is injured and he doesn’t want that out there because teams will start running on him every time he touches the ball.
A player lays down a sacrifice bunt in the first inning and the manager gets roasted for playing small ball too early. Later you find out the player did it on his own and was being selfish: if he gets a good bunt down he gets a hit, if the bunt’s mediocre it goes as a sacrifice.
All those above examples really happened. In the old days — like 2010 — I could wait to find out the real story before writing about those things. Now, I’m expected to comment right away.
If you’re covering baseball you’re expected to be on Twitter and if you’re on Twitter you’re expected to tweet fairly often. So people are desperately looking for things to comment about and that’s why we send you important information like the guy you just watched hit a home run, did in fact hit a home run. We’re also...
So when Jarrod Dyson doesn’t hustle down to first base, there’s no time to find out why; just get it out there. And if he gets unfairly criticized, that’s his problem.
Like I said at the beginning; if Jarrod Dyson’s hurt, some of us owe him an apology — and that includes me.
Conventional wisdom has it that the China juggernaut is unstoppable and that the world must adjust to the reality of the Asian giant as a—perhaps the—major global power. A mini-industry of “China rise” prognosticators has emerged over the past decade, all painting a picture of a twenty-first-century world in which Chin...
Recall that not so long ago, in the 1980s, similar forecasts were made about Japan being “number one” and joining the elite club of great powers—before it sank into a three-decade stagnation and was shown to be a single-dimensional power (economic) that did not have a broader foundation of national attributes to fall b...
Certainly China is the world’s most important rising power—far exceeding the capacities of India, Brazil and South Africa—and in some categories it has already surpassed the capabilities of other “middle powers” like Russia, Japan, Britain, Germany and France. By many measures, China is now the world’s undisputed secon...
Capabilities, however, are but one measure of national and international power—and not the most important one. Generations of social scientists have determined that a more significant indicator of power is influence—the ability to shape events and the actions of others. As the late political scientist Robert Dahl famou...
When we look at China’s presence and behavior on the world stage today, we need to look beyond its superficially impressive capabilities and ask: Is China actually influencing the actions of others and the trajectory of international affairs in various domains? The short answer is: not very much, if at all. In very few...
Moreover, when China’s capabilities are carefully examined, they are not so strong. Many indicators are quantitatively impressive, but they are not qualitatively so. It is the lack of qualitative power that translates into China’s lack of real influence. The Chinese have the proverb wai ying, nei ruan: strong on the ou...
This can be seen in five broad areas: China’s international diplomacy, military capabilities, cultural presence, economic power and the domestic elements that underpin China’s global posture. Let’s examine each in turn.
In formal respects, China’s diplomacy has truly gone global. Over the past forty years China has traveled a path from a nation isolated from the international community to one integrated into it. Today, Beijing enjoys diplomatic relations with 175 countries, is a member of more than 150 international organizations and ...
Despite this integration into the international community and Beijing’s active diplomacy, the diplomatic sphere is a realm where China’s position as a partial power is apparent. On the one hand, it enjoys the symbols of being a major world power. It’s a permanent member of the UN Security Council, a member of the G-20 ...
Being a global power requires getting in the middle of disputes, bringing parties together, forging coalitions and consensus, and—yes—using pressure when necessary. Beijing prefers to sit on the sidelines and simply call for nations to solve their problems through “peaceful means” and to find “win-win solutions.” Such ...
Instead, Beijing’s high-level diplomacy is really a kind of theatrical show, more symbolism than substance. It is intended primarily to enhance the Chinese Communist Party’s (CCP) legitimacy among domestic audiences by showing Chinese leaders hobnobbing with the world’s elite, while signaling to the international commu...
The notable exception to this general passivity concerns China’s own neuralgic and narrowly defined interests: Taiwan, Tibet, Xinjiang, human rights and its contested territorial claims. On these issues Beijing is hypervigilant and diplomatically forceful, but its attempts to defend these interests are often clumsy and...
When it comes to global governance, which entails contributing to the common good proportionate to a nation’s aggregate capabilities, Beijing’s behavior generally parallels the passivity and narrow-mindedness of the rest of its diplomacy. China does contribute to various aspects of global governance: UN peacekeeping op...
Why is China’s global-governance diplomacy so constrained? There are three main reasons. First, there exists deep skepticism inside of China about the liberal premises and basic concept of global governance, seeing it as the latest “trap” laid by the West (primarily the United States) to “bleed” China by getting it inv...
As a result, in the realm of diplomacy—bilateral, multilateral and global governance—Beijing still demonstrates a distinct passivity and reluctance to get involved. It is far from being the “responsible stakeholder” that Robert Zoellick called for in 2005. Chinese diplomacy remains narrowly self-interested, and Beijing...
China’s military capabilities are another area where it is a partial power: increasingly a regional power, but by no means a global power. China is not able to project power outside of its Asian neighborhood (other than through its intercontinental ballistic missiles, space program and cyberwarfare capacities), and eve...
To be sure, China’s military modernization has been advancing steadily for twenty-five years. It now has the world’s second-largest military budget ($131.6 billion in the 2014 official budget), largest standing armed forces, scores of new advanced weapons, a navy that is sailing further and further out into the western...
Moreover, strategically, China can be described as a “lonely power”—lacking close friends and possessing no allies. Even in China’s closest relationship (with Russia), elements of distrust and historical suspicions percolate beneath the surface of seemingly harmonious state-to-state relations. Not a single other nation...
Turning from hard power to soft power, how does China stack up as a global cultural power? Not well. No other societies are taking their cultural cues from China, no other countries are seeking to copy the Chinese political system, and its economic system is not replicable elsewhere. Despite the enormous efforts and re...
China is not a magnet for others to emulate—culturally, socially, economically or politically. The problem for China in all four realms is that it is sui generis. China lacks universal appeal beyond its borders or ethnic Chinese communities. Largely because of China’s cultural, economic, social and political uniqueness...
China’s cultural products—art, film, literature, music, education—are still relatively unknown outside of China and do not set global cultural trends. As admirable as China’s economic development is, it is the product of a unique combination of features that cannot be replicated in other countries (competitive economie...
What about China’s economic power? This is the one area where one would expect China to be a global power and trendsetter—yet China’s impact is much more shallow than anticipated. As in other areas, it is quantitatively impressive but qualitatively weak. China is the world’s largest trading nation, but its exports are ...
When evaluated qualitatively instead of quantitatively, China’s global economic profile is not very impressive. It remains a processing-and-assembly economy—not a creative and inventive one. Most of the goods that are assembled or produced in China for export are intellectually created elsewhere. China’s rampant theft ...
If China is to spur innovation, it will, of course, have to invest more in research-and-development funding. According to the National Science Foundation, in 2009 China spent only 1.7 percent of its GDP on research and development, compared with 2.9 percent in the United States, 2.8 percent in Germany and over 3.3 perc...
As a result of China’s chronic “innovation deficit,” the nation is now mired in the infamous “middle-income trap.” The only way out of the trap is through innovation—as Japan, South Korea, Singapore and Taiwan previously proved. And this requires much more than government investment in research and development—it requi...

Subsets and Splits

No community queries yet

The top public SQL queries from the community will appear here once available.