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The three key priorities are different to the previous year, reflecting how the service is developing. These are family-focused practice, workforce development and making sure children get the right service at the right time from the right people.
The improvement plan, which sets out a range of actions required to help meet the full list of priorities, is monitored on a monthly basis by the management team to ensure progress is being made and to track the impact it is having.
A report to councillors explained that one of the aspects ‘central to the plan succeeding’ is the retention of experienced social workers, which continues to be a challenge in parts of the county.
A potential therapy for TTP, or thrombotic thrombocytopenic purpura has been discovered by University of Alabama at Birmingham researchers. TTP is a rare and potentially deadly blood-clotting disorder.
The researchers deliver this therapeutic enzyme via the cellular equivalent of a Trojan Horse, using tiny blood cell platelets as their protective delivery vehicle, with a key enzyme hidden inside.
TTP, or thrombotic thrombocytopenic purpura, appears as blood clots in small arterioles throughout the body, particularly in the brain, heart, pancreas and kidneys, resulting in organ damage. The onset of symptoms can be sudden and nonspecific, and the in-hospital death rate remains as high as 20 percent.
Loss of the enzyme allows destructive microvascular clots to form in important organ tissues. UAB researchers, led by X. Long Zheng, M.D., Ph.D., Robert B. Adams Professor and Division Director of Laboratory Medicine in the Department of Pathology in UAB's School of Medicine, have now reported that platelets can sponta...
"This novel approach could be translated to patient care once rADAMTS13 receives an approval from the U.S. Food and Drug Administration for therapy of congenital TTP." In previous work published in Blood in 2015, the UAB researchers created transgenic mice, where human rADAMTS13 was expressed exclusively in the platele...
As the next step toward patient care, Zheng and colleagues sought to determine whether platelets outside of the body could be loaded with rADAMTS13, such as in blood collected for transfusions. If so, they also wanted to test whether transfusion with those rADAMTS13-loaded platelets could be as effective to block throm...
Four key experiments -- described in a study published in the American Heart Association journal Arteriosclerosis, Thrombosis and Vascular Biology, or ATVB -- answered those questions. First, the researchers incubated isolated human platelets -- which are one-fifth the diameter of red blood cells and have a normal func...
Second, they showed that the rADAMTS13 taken up by the human platelets remained intact and enzymatically active against von Willebrand factor, a key ingredient for platelet adhesion and aggregation. Also, the rADAMTS13 was releasable under arterial shear conditions that cause platelet aggregates to break, as simulated ...
Third, using microfluidic channels coated with a fibrillar collagen that simulates the flow in arterioles and presents a surface for clot formation, they showed that addition of rADAMTS13-loaded platelets to normal, TTP-patient and reconstituted-TTP blood dramatically inhibited in vitro thrombus formation under arteria...
Finally, they showed that transfusion of the rADAMTS13-loaded mouse platelets into genetically engineered mice lacking ADAMTS13 dramatically inhibited thrombus formation in abdominal arterioles after injury.
Thus, it may be possible to pack rADAMTS13 inside human platelets during the time that bags of donated blood sit at room temperature for three days as they are tested for multiple infectious disease markers. These packed platelets could then be transfused into patients with TTP. While routine transfusion of platelets i...
Other researchers have worked on therapeutic strategies to bypass the autoantibody for TTP treatment, with some success. However, unlike Zheng's platelet-ADAMTS13 approach, none of those strategies have addressed the underlying mechanism of TTP -- a lack of ADAMTS13 and/or autoantibody against ADAMTS13.
Elucidating how blood clots contract could help in the development of new treatments for heart attack and stroke, says study.
Blood clotting factor stops stem cells in the brain from producing myelin, and disrupts myelin repair in nervous system diseases, says study.
Immune thrombocytopenia, is a rare auto-immune disease where the body's own antibodies kills the blood cells responsible for blood clotting.
The Obama administration supports "democracy" and "self determination" in the Middle East—two euphemisms that, in the real world, refer to "mob-rule" and "Islamic radicalization," respectively. Yet, as Jimmy Carter recently put it: "I don't have any problem with that [an "Islamist victory" in Egypt], and the U.S. gover...
Sounds fair enough. The problem, however, is that Muslim clerics openly and unequivocally characterize democracy and elections as tools to be discarded once they empower Sharia law. Thus Dr. Talat Zahran holds that it is "obligatory to cheat at elections—a beautiful thing"; and Sheikh Abdel Shahat insists that democrac...
The Obama administration can overlook such election-exploitation because the majority of Muslims are either indifferent or willing to go along with the gag—with only a minority (secularists, Copts, etc.) in Egypt actually objecting to how elections are being used to empower Sharia-enforcing Muslims.
But what if Muslims do not win elections? What if there are equal amounts of non-Muslims voting—and an "infidel" wins? What then? Then we get situations like Nigeria.
While many are aware that Boko Haram and other Islamic elements are waging jihad against the government of Nigeria, specifically targeting Christians, often overlooked is that the jihad was provoked into full-blown activity because a Christian won fair elections (Nigeria is about evenly split between Christians and Mus...
The current wave of riots was triggered by the Independent National Election Commission's (INEC) announcement on Monday [April 18, 2011] that the incumbent President, Dr. Goodluck Jonathan, won in the initial round of ballot counts. That there were riots in the largely Muslim inhabited northern states where the defeat ...
Note some key words: Muslims felt "entitled" to the presidency and seek to "correct" the fact that a Christian won elections—which they assumed "a temporary matter."
Of course, had elections empowered a like-minded Muslim, the same jihadis would still be there, would still have the same savage intent for Christians and Westerners—Boko Haram means "Western education is forbidden." But there would not be a fullblown jihad, and Obama would be singing praises to Nigerian democracy and ...
Yet the same jihadi intent would be there, only dormant. Like Egypt's Muslim Brotherhood—whose ultimate goal is "mastership of the world"—they would not need to expose themselves via jihad, would be biding their time and consolidating their strength.
We say—regardless of the outcome of the elections—whether he [his colleague, the aforementioned al-Shahat] wins or loses, we will not permit an infidel [kafir] to be appointed to a post where he assumes authority over Muslims. This is forbidden. Allah said: "Never will Allah grant to infidels a way [to triumph] over th...
What will you and your associates do, Sheikh Burhami—wage jihad? Of course, that will not be necessary: unlike Nigeria, most of Egypt is Muslim; one way or another, "elections" will realize the Islamist agenda.
Thus, whether by word (al-Burhami) or deed (Boko Haram) those who seek to make Islam supreme prove that democracy and elections are acceptable only insofar as they enable Sharia. Conversely, if they lead to something that contradicts Sharia—for instance, by bringing a Christian infidel to power—then the perennial jihad...
While Pat Shurmur was sitting in the stands in Mobile, Ala., watching Senior Bowl practices last Wednesday, his first official assignment as head coach of the Giants, his cellphone rang. On the other end was the franchise quarterback, Eli Manning.
It was a very good sign for Manning that Shurmur took the call.
This was the start of a professional relationship that will largely shape Shurmur’s time with the Giants and carve the final notches in Manning’s legacy. That Shurmur reached out to only one player in his first few days on the job — Shurmur left a message and Manning called him back — is not surprising — and that the o...
A few Giants players were in the building Friday morning as Shurmur was officially introduced as the 18th head coach in team history, but none of them ventured into the press conference. When the festivities concluded, Shurmur, The Post learned, spotted and chatted with one player, who was finishing up lunch in the tea...
Back when Tom Coughlin took over in 2004, the incumbent Giants quarterback, Kerry Collins, was still on the roster. When they passed each other in the hallways that offseason, Coughlin did not even acknowledge Collins, walking by him with that fast-paced gait, eyes averting Collins, a player whose career has been salva...
Manning fits prominently into Shurmur’s plans. When the new coach reached out, Manning could not immediately take the call, as he was attempting to get his three young daughters to sit at the dinner table. Shurmur, with three daughters (and a son) of his own, no doubt understood the need for a Manning callback.
Anyone who was in the room that remarkable day — Jan. 5, 2016 — to witness a remarkable coach-quarterback bond will never forget what Coughlin meant to Manning, and Manning meant to Coughlin. It was Coughlin’s final press conference after he and the Giants agreed to part ways — the Giants said your time is up and Cough...
At the time, Manning had just turned 35, coming off a fine season (career-high 35 touchdown passes and career-best 93.9 passer rating) on a team that finished 6-10. That was two head coaches ago. Ben McAdoo is gone and Shurmur has arrived, with a stuffed résumé of helping quarterbacks reach and, at times, exceed their ...
Later this week, Manning will head to Minneapolis on behalf of Gatorade, one of the many companies that pay for him to pitch their product. This is as close to Super Bowl LII as he will get, coming off a 3-13 season infected with injuries, dysfunction and, yes, not nearly enough plays made by Manning and his depleted o...
Shurmur says he cannot wait to begin working with Manning, who already has started studying the way Shurmur called the game and operated his offense with the Vikings. These are two serious-minded, lack-of-flash individuals about to embark on a new chapter, together.
Anarkismo.net makes available for downloading and distribution a 13 page PDF pamphlet of the Spanish Revolution text 'Towards a Fresh Revolution' published in 1938 by the Friends of Durruti.
The friends of Durutti were setup in 1937 by rank and file members of the CNT and members of CNT columns resisting militarisation. "Towards a fresh revolution" was published in 1938 as "a message of hope and a determination to renew the fight against an internationalism."
When you download the file please leave a comment here to let us know whereabouts you are distributing it and how many you are distributing.
Just wanted to ask if you could please put page numbers in your PDFs. I had a problem the other day where I dropped some pages when I was copying them and took a while to sort them out again.
From today the flu epidemic with the anti-epidemic measures is cancelled in the regions of Gabrovo and Razgrad, the Ministry of Health said. On Tuesday the measures were lifted in 11 regions – Sofia city, Kyustendil, Shumen, Vidin, Vratsa, Pleven, Dobrich, Sliven, Varna, Veliko Tarnovo and Smolyan, except the municipal...
The region of Blagoevgrad will follow suit on February 7.
Only in Montana the epidemic was extended until February 8 because of the continuing increase in the cases of influenza and acute respiratory diseases.
Should Mauricio Pochettino's Tottenham prioritise the Champions League over the Premier League after dominating their group?
Should Mauricio Pochettino’s Tottenham prioritise the Champions League over the Premier League after dominating their group?
ON Tuesday night, Tottenham, with goals from Harry Kane and Son Heung-min, came from behind to beat Borussia Dortmund 2-1 in Germany.
Going back 12 months, it’s a result that shows how far Mauricio Pochettino’s team have come and the progress they have made.
It was Bayer Leverkusen who, as well as Monaco, beat Spurs in last year’s competition.
Spurs’ Champions League adventure will continue into 2018, but Football Whispers wonder if the North London side should prioritise success in Europe over the Premier League.
Bringing all three points back from Signal Iduna Park confirms Spurs have not only qualified for the last-16, but they have secured top spot in their group.
When the draw was made, with Real Madrid and BVB, many thought the North London side would struggle.
When the names are pulled out the hat for who they will face in the knockout stage, they know they will be able to avoid clubs like Paris Saint-Germain and Barcelona.
There are no easy games, but any slight advantage in your favour helps.
Manchester City are flying. They hold an eight-point lead at the top of the Premier League and are 11 ahead of Spurs.
Winning the title is a long-shot, and although not impossible, it’s unlikely.
Should Tottenham prioritise the Champions League after storming their group?
There is an argument which suggests if Pochettino’s legacy of building this talented young side wants to be remembered, he needs to win a trophy.
At this stage, there is perhaps more chance of the Argentine leading the club to Champions League success than a Premier League title.
However, there is a much bigger picture to take into consideration.
Unlike in France, Germany and Spain, the top clubs in England don’t have the luxury of being almost guaranteed Champions League qualification.
PSG can have a bad season and finish second, maybe even third If they were terrible, and they would still have a chance to qualify.
The same can be said for Barcelona, Real Madrid and Bayern Munich. It’s unthinkable they wouldn’t make it with the talent they have in their squads.
Spurs are aiming to match the talent of those clubs and with each impressive performance in Europe, they are proving themselves.
Yet, they face a domestic battle with five other clubs for just four places.
Liverpool and Arsenal are fighting with the current top four to secure a place in next year’s competition.
Both clubs and their fan bases deem it necessary that they qualify for Europe’s elite competition.
This is the problem with the Premier League’s top six. As long as it exists, two clubs, who will demand Champions League football, are going to miss out.
Currently playing at Wembley while their new stadium is being finished, it would be a disaster to Spurs’ plan if they were not able to host the biggest games in their new home.
It would also limit what they could do with their squad due to their strict wage structure.
Pochettino now boasts strength and options across most positions of his squad that allows him to make changes and rest players without significantly weakening his starting XI.
No one can predict the future, but if they avoid a huge injury crisis, they should have enough to fight on both fronts.
Putting all your efforts into making the latter stages of the Champions League is very short-term thinking.
Domestic success, especially when you are still growing your infrastructure and the base on which Spurs can flourish from over the next 10 years, should be their priority.
To grow and challenge England and Europe’s established clubs, you need constant Champions League football.
In the Premier League, that is tougher to guarantee than in most countries.
You can’t afford either on and off the pitch to take your eye on the long-term prize.
Putting all their eggs in the Champions League basket this term could damage the future of Tottenham and is purely short-term thinking.
RSL president says City of Sydney support for Anzac Day pales in comparison to other community activities including $400,000 to Sydney Mardi Gras Parade.
With the federal election campaign (back) in full swing — and water, tax and climate change in full focus — it would be understandable to have forgotten about another ballot, one not expected to be resolved until the last week of June.
Councils across NSW are struggling to pay for infrastructure such as roads and bridges because of cost shifting and a cap on rate increases.
The areas with the highest population density are not those with the lowest amount of public open space for their residents.
"The wretched abominations constitute a blot on one of our finest buildings."
Sports Minister John Sidoti’s name has barely been stencilled onto door of his fifteenth floor office at 52 Martin Place but we hear he's already pondering an important matter of state - he must choose a new trustee to appoint to the Sydney Cricket and Sports Ground Trust.
The elite Sydney girls' school may build a swimming pool and childcare centre under its controversial $48.7 million masterplan.
My obsessive-compulsive aural tendencies have undoubtedly been noted by careful—and dare I say, patient—readers who’ve been inundated with Halloween, Xmas, Valentine’s Day and themed playlists of all demoninations during my brief tenure. And now ... cover songs. Whether you love ‘em or hate ‘em, they’ve been around for...
Refresh your redux memory with Alibi Music Editor Samantha Anne Carrillo and rock out to a playlist of Nuevo Mexicano cover songs.
Before the summer vacation begin four-storytorey school building has been completed in an elementary school in Quezon City, the Department of Public Works and Highways (DPWH) said.
The additional school building was constructed to accommodate more students in D. Tuazon Elementary School in Quezon City for the incoming school year.
According to the department, the new school building has eight classrooms equipped with comfortable rooms, emergency exits, fire protection facilities, cistern, and water tanks. A total of P18.7-million was spent to complete the project.
“This project was undertaken to provide a more spacious and sturdy facility wherein the security and safety of our students and teachers will not be compromised,” DPWH Secretary Mark Villar said.
With the additional classrooms, the usual 50:1 ratio of students is now lessened to 40:1, providing students a more conducive learning environment, the secretary added.
The project was implemented by the DPWH with the use of Basic Education Facilities Fund of the Department of Education.
The stories are free, but guacamole is still extra.
Fast food restaurant chain Chipotle is continuing its quest to make sure diners have something to read while they scarf down their burritos. The company has announced 11 new contributors to its "Cultivating Thought" series, including Jonathan Franzen, Colson Whitehead and nine other authors.
The new bags and cups should be in stores on Monday. The other new participating authors are Mary Roach, Laura Esquivel, Laura Hillenbrand, M.T. Anderson (just longlisted for the National Book Award), Lois Lowry, Tom Perrotta, Sue Monk Kidd, Anthony Doerr and Stephen J. Dubner.
Foer serves as the curator of the series, and one of the new contributors cited his involvement as the reason they signed on. "Freakonomics" co-author Dubner said he agreed to the project because "Jonathan asked! I love his writing and respect his mind."

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