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IGFs are hormones that stimulate growth. IGF-1 and IGF-2 are found naturally in our blood, but the new study revealed that breast cancer tumors also express IGF-1 and -2, which helps them to grow. |
Why are some forms of breast cancer more aggressive than others? A new study sheds some much-needed light. |
Specifically, macrophages were found to express high levels of these hormones, which caused the cancer to spread to the lungs. |
Furthermore, Dr. Mielgo and team examined breast cancer patients and found that IGF receptors were highly active in 75 percent of them, and this percentage was proportional to macrophage infiltration and how advanced the tumor was. |
Additionally, "In patients with invasive breast cancer, activation of Insulin/IGF-1 receptors increased to 87 percent," write the authors. |
Importantly, the team blocked IGF levels in mice and combined this intervention with paclitaxel, which is a common chemotherapy drug used in the most aggressive forms of breast cancer. |
They compared the results of this combined therapy with those of using paclitaxel alone. |
The combined intervention led to "a significant reduction in tumor cell proliferation and lung metastasis." |
As Dr. Mielgo explains, "[These] findings provide the rationale for further developing the combination of paclitaxel with IGF blockers for the treatment of invasive breast cancer." |
"I am thrilled by our findings, as the combination therapy is more effective than the current treatment in preclinical models of breast cancer." |
I would like to tell you about my experience with unions. There was a strike at Pittsburgh Plate Glass (PPG) in Ford City, Pa., where I grew up. |
The union workers stayed out on strike for over 18 months for less than $1 an hour increase. |
This action severely crippled Ford Motor Co. who was buying windshields and side glass from this plant for their new cars, and caused Ford to subsequently purchase Libby Owens Company and make its own glass products needed for the new cars (thus Libby-Owens-Ford Corp. was created). |
What used to be seven operating PPG plants in this town of 5,000 resulted in the loss of 2,000 residents and the acquisition of a new city park where PPG used to be, as the plant only recovered to 30 percent of its previous stature. |
I had three brothers-in-law working: one with 22 years service who was never called back to PPG, another had to relocate 70 miles north to another PPG plant to work and only one was called back locally. Incidentally, he was the union grievance arbitrator. |
All of this was caused because of union greed. |
I also know two union steelworkers who used to brag that their wages were more than $2 an hour higher than in other industries. |
Well, today, the steel plants surrounding Pittsburgh are silent and being torn town to make room for more parks. |
And why? Simply said, they priced themselves out of business when it became cheaper to import steel from Japan. |
Oh, environmentalists are partly to blame, but again it was the union greed and the constant strikes and work slowdowns that brought them their demise. |
Back in the days when my dad and father-in-law were coal miners, and had to work in unbelievable, unsafe conditions, the unions were necessary -- for safety's sake and the health of the workers. |
But today, what is the real purpose of the unions? I see it as collecting dues, stirring up discontent, robbing the community coffers, and influencing our elections and our president. |
Unions have to go, just like their time has come and gone. Just look at proposed Card Check legislation, the performance of government employees, the teachers who sit in New York in the "rubber room" and can't be fired, the postal service (which spends over $1 million a day to keep extra mailmen sitting around in case ... |
Google announced on the AdWords blog two new features to help you track your AdWords performance, campaign groups and performance targets. |
Jon Diorio from Google said on Google+ that he is "terribly excited" about this launch, adding "if you want to reduce the amount of time you spend monitoring and tracking performance against your goals, do go check it out." |
Create a campaign group: You can now package AdWords campaigns (including Video, Display, Search, and Shopping campaigns) into a single campaign group. For our holiday example, set up your YouTube and Display campaigns, select “campaign groups” from the left menu, and group those two campaigns together to create a camp... |
Set a performance target: Performance targets make it easier to monitor and reach your performance goals for each campaign group. Tell us how many clicks or conversions you want to receive, how much you want to spend, and what average CPC or CPA you wish to maintain. We'll then automatically show you a single view of h... |
The relationship between the fixed image and movement really interests me. To captivate the eye by transforming the clear into a blur and the fixed into a movement is an active ingredient in my research. I paint in a very instinctive way, following the example of the expressionists who fascinate me (Francis Bacon, Paul... |
Lou will be showing a new series called Faces/Paper Faces at Tache Gallery in New York from March 24-April 23. Below are a selection of Lou’s dynamic paintings from several recent series. |
Make 2018 a year to remember by booking that once-in-a-lifetime dream holiday. A World Cruise may float your boat … hot air ballooning over the Egyptian pyramids could have you on Cloud 9 … you may have a whale of a time nature-watching in the Arctic … or perhaps revving a Harley down Route 66 is your personal highway ... |
We get most of our Vitamin D (essential for healthy bones) from exposure to sunlight, so a week or two in a warm climate delivers a great health boost, provided you are careful and avoid risking sun damage. When you are in a warm climate it’s easier to eat lighter, healthier foods too and we all know that holidays are ... |
Everyone wants a great value holiday and there’s no better place to do your comparison shopping that at Belfast Telegraph Holiday World where the deals and destinations are all under one roof. Savvy travellers know, however, that great value isn’t only about the ticket price: extras and upgrades can be worth their weig... |
Family isn’t just for Christmas. Keep that promise of staying better connected this year. Now is the time to book that big trip Down Under, plan a massive family reunion in North America or catch ups in Ireland and the UK. Or maybe you’ll bring everyone back home to Northern Ireland for a special family celebration. St... |
We’ve only just got over the joy (not to mention the expense!) of Christmas gift giving, but we’re already looking ahead to a year that will be jam-packed with birthdays, anniversaries and a host of special occasions. Instead of angsting over how best to mark those highpoints, make it easy on yourself and delight recip... |
If you love all those nature programmes on television, just think how amazing it would be to get up close and personal with wildlife! The world is your oyster! Go on safari in Africa to see the ‘Big 5’ game animals, cruise in the wake of Darwin to see nature in the raw in the stunning Galápagos Islands or trek the jung... |
All the world loves a lover and luvved-up couples just love to travel! Whether it’s a romantic break in a secluded spot close to home, a weekend in one of the Europe’s romantic capitals or a far-flung adventure for two, a holiday provides great ‘together’ time. Lots of romantics choose to propose while on holiday too a... |
It’s great to be planning major holidays, but don’t forget the restorative power of a day spent exploring the great destinations which are close to home and close to our hearts. Make a day of it and visit some of the great sights Northern Ireland has to offer. Wallow in our glorious scenery and check out the tourist at... |
It’s show time! Take your seat in the mini lecture theatre at the Oasis Travel Cruise Pavilion to enjoy fact-filled presentations from some of the world’s leading cruise companies. Confer with Oasis consultants to discover deals and destinations that are sure to float your boat. Whether you’re planning a spectacular ro... |
Holidays under canvas have always been firm family favourites and now there are more choices than ever before. From bargains for the budget- conscious to luxury glamping for the less hardy amongst us; from great breaks backpacking in the backwoods to fun filled tented holidays in supremely well organised family-friendl... |
11. Hold The Front Page! |
Be first with the news as new deals and destinations are revealed for 2018. You’ll find holidays to hit the headlines at the Belfast Telegraph Travel stand at Holiday World. Our experts will sharing their passion for travel, showcasing a range of quality travel experiences perfectly tailored to suit local holidaymakers... |
12. Here Come The Girls! |
When the goin’ gets tough, the tough go shoppin’…or sight-seein’. Girlie holiday breaks have never been more popular and age, it seems, is no barrier. While the teens are bound for the clubbing capitals of Europe, their mums (and grans) are hightailing it to horizons new. Golf and tennis breaks are always winners with ... |
Baby boomers are inveterate travellers. Now they’ve have paid off their mortgages and seen the kids through uni they’re relishing ‘me time’. Citybreaks, and hotel stopovers close to home break up the year for retirees, while many also choose to holiday abroad several times each year – sometimes they even take the young... |
Whatever your age or life circumstance, holidaying alone can be a daunting prospect. In the past, one of the most daunting aspects of solo adventure has been the dreaded single supplement. Now, as more singletons choose to go it alone on vacation, holiday companies have responded with new concepts and pricing structure... |
Still dreaming about having your own special place in the sun, or a home from home in a much-loved holiday haven? Investing in a villa, apartment, mobile or park-home could be the key to a lifetime of great breaks and vacations for you and your family – get the lie of the land and discover how your dream could become r... |
Carnivals, fiestas and traditional celebrations make for marvellous holiday memories. Talk to your travel agent about timing your holiday so that you can connect with fun events. Add a splash of colour to your Indian adventure by joining in the dye throwing extravaganza of Holi … you’ll find the Battle of the Flowers n... |
The annual family holiday just got even bigger! Multi-generational holidays are on the rise as people waken up to the benefits of enjoying quality family time together in a vacation setting. It’s a great way to bond, plus there are super discounts to be had when you travel as part of a larger group. It may also make hi... |
Dream big! Is this the year to push the boundaries with your holiday choices? Trek Machu Picchu in Peru … stay in a jungle eco-lodge in Costa Rica … marvel at the Taj Mahal … go on the vampire trail in Transylvania … walk the Camino de Santiago in Spain …cycle in Vietnam … board the Trans-Siberian Express … There is li... |
Whether you’re ready to splash the cash on the holiday of a lifetime or looking for a canny value deal, your 2018 holiday starts right here at Belfast Telegraph Holiday World. Make Titanic Exhibition Centre your first port of call and be prepared to shop ‘til you drop as exhibitors from around the world and close to ho... |
20. You gotta be in it to win it! |
Play your cards right and you could be a winner in one of the many on-stand draws and competitions at the bustling Belfast Telegraph Holiday World show this weekend … and wouldn’t it be wonderful to be heading off for a great break at someone else’s expense? If you don’t get lucky with a prize win, don’t worry: with sp... |
Nip along and see what’s hot and happening with amazing deals, destinations, value and variety. There’s entertainment as well as information on offer as you gather inspiration for short breaks, away days and holidays in 2018 and beyond. With so many choices under one roof, there’s no better time or place to plan your i... |
When deciding where to go for your next short-haul holiday, the same places probably spring to mind. |
By Geoff Frazer The last time I survived three days without phone signal was when my three-year-old son Noah dropped my iPhone down the toilet to see how big a splash he could make. |
By Paul Ferguson Within seconds of arriving at the salubrious resort in Cascais, my three-year-old twins were whizzing around the Martinhal reception area on the hotel-provided bicycles. |
A gentle, meandering river cruise is one of the best ways to see and understand a new place. The rivers are always the lifeline of the cities they flow through - the beating heart. It’s on the banks of rivers that cities were founded and flourished. |
CBSSports.com Shop - Everything Sports! Score your new UTEP Miners Home & Office Merchandise at the Official Store of CBS Sports. We have your new officially licensed University of Texas at El Paso School Stuff including Miners Clocks, Lamps, Pillows, Grill Covers, Frames, Calendars and UTEP Office Supplies. Get your U... |
Pokemon GO players meet at Sydney Opera House on July 20, 2016 in Sydney, Australia. |
Walking along Jones Beach Boardwalk one sultry August night last week, I paused frequently to line up Pokémon and catch them as my niece, her boyfriend and my two college-age kids walking alongside me did the same (only my wife abstained). As we neared the flagpole at the entrance to the beach’s main field, we spotted ... |
A day later, as I descended a staircase at Penn Station in New York on my way home from work, I spotted a woman just ahead of me staring intently at her phone. The Pokémon Go map was clearly visible on her screen. |
Like her, I still spend the occasional commute home catching Pokémon, draining Pokestops of Pokeballs, gems and eggs and even battling and losing at most gyms. |
Even though I predicted a quick end to the Pokémon Go craze, I don’t think the love affair is completely over. |
There may, however, be signs that its ebbing. qnd, to be honest, the next few months could be especially tough for Pokémon Go. |
A recent report on Comicbook.com claimed the app had suddenly lost 20% of its U.S. user base. |
The source of this article's hyperbolic headline was some new data from survey and analysis company SurveyMonkey. After enjoying nearly 40M weekly active users as of July 23, Pokémon Go had tumbled to just a tick over 30M as of August 12. SurveyMonkey’s numbers are somewhat limited. It uses a panel of U.S.-based smartp... |
Pokemon Go weekly actives compared to other apps. |
If nothing else, Pokémon Go’s stats are more volatile than other top apps, including Instagram, Snapchat, and Twitter (which it’s still outpacing). Prisma, another app that exploded the same week as Pokémon Go, is definitely more hype than impact. |
Weekly Active users, though, do not tell the whole story. |
I decided to dig into more of SurveyMonkey’s Stats to see if I could find any data-based support for my perception that there’s still strong interest in Pokémon Go. |
Pokemon Go Monthly Active Users. |
When I pulled up Monthly Active users, the picture brightened a bit. At its height in early August, Pokémon Go had over 55M monthly actives (significant when you consider that Twitter has 311M MAUs). The number has declined since then, but the drop-off appears small. It probably still has at least 50M MAUs. |
The download picture is even better. Pokémon Go consistently has better download stats than Instagram, Twitter and Snapchat. The app remains among the Top 10 Free Apps in the Apple’s App Store. |
So the news is actually still good for Pokémon Go. Lot of downloads, tens of millions of people playing each week and, in the real world, people still gathering at parks to hunt Pokémon in clusters. |
And yet, that may be about to change. |
The most interesting chart I found on SurveyMonkey is the Monthly Engagement Ratio, which in a rolling fashion compares Daily Active Users to Monthly Actives. It’s supposed to be a measure of stickiness. The table SurveyMonkey spit out for the past month is fascinating. |
It essentially shows engagement rising sharply midweek, soaring on the weekends, and nose-diving at the beginning of the week over and over again. This indicates that people play on Thursday and Fridays (maybe in the evenings) and heavily over the weekend, while basically stopping Monday-to-Wed (and sometimes all the w... |
I expect that trend to continue and the active users numbers to take a big hit between now and January. As teens head to college and kids and adults prepare for the school year, and especially once the school year kicks off in earnest, time outside will be significantly curbed. |
That's bad news for an app that encourages everyone to get outside and go catch Pokémon. |
There are signs, though, that even if Pokémon Go takes a major hit this fall, the Pokémon brand is resurgent. |
According to one report, Nintendo, home of the Pokémon brand but not the game's parent, is crediting the game with reigniting interest in its Nintendo 3DS system, which it launched in 2011. In my own home, my daughter suddenly bought herself one of these aging systems. Apparently, players are looking for Pokémon games ... |
If Pokémon Go parent Niantic is smart, it will accelerate development of the Pokémon Go wearable, which was supposed to launch back in June, and all the special features the company has been promising. These include trading Pokémon between players and adding hundreds of new Pokémon to the original 150. |
Doing so within the next two months could help Pokémon Go limp through a shut-in winter (at least in the U.S.) and emerge in the spring with some new momentum. |
Whatever Niantic does, though, I’m convinced that we’re shifting into the second phase of Pokémon Go’s existence. The craze is over. Now Pokémon Go gets to live the life of a popular (maybe even Essential) app. With frequent updates for users and in-app purchases driving revenue for Niantic, that could be a very good l... |
President of the Minnesota Farm Bureau feels like a bad dream has come true. |
Minnesota’s greatest potential casualties in the nascent U.S.-China trade war are the state’s soybean farmers. They now face a 25 percent price hike on soybeans they sell in China. Whether they can find alternative markets to offset lost Chinese sales or less revenue from those sales is unclear. China is Minnesota’s ma... |
Blue Earth County soybean farmer Kevin Paap said Friday he has not yet heard of any canceled purchases. But Paap, president of the Minnesota Farm Bureau, feels like a bad dream has come true. The imposition of the U.S. tariffs on Chinese imports that began Friday will now trigger retaliatory tariffs on U.S. products so... |
Minnetonka-based Cargill said it has seen a “significant slowdown” in sales by farmers of soybeans, a reaction to the 18 percent decline in soybean prices since May. “The economic turmoil and uncertainties resulting from tariffs are harming U.S. farmers, and trade concerns have played a major role in this price drop,” ... |
The Chinese tariff list also includes dozens of dairy, poultry and pork items, which could have an impact on Minnesota’s livestock sector. |
U.S.-made off-road vehicles appear on the list as well. Polaris Industries, a major manufacturer of such products could be affected if it ships vehicles to China. The company could not be reached for comment Friday. But it may be spared as its most recent annual report lists a “wholegoods manufacturing” operation in Sh... |
Minnesota companies that purchase certain kinds of manufacturing machinery and some electrical components from China will also see their costs for those products increase 25 percent as a result of the Trump tariffs on $34 billion worth of Chinese imports. |
Several pieces of evidence (see H and W) suggest that the authorities knew in advance that the Boeing 747 which blew up over Lockerbie in southern Scotland on December 21 1988 was in danger. The German newspaper Die Zeit claimed that the South African foreign minister, Pik Botha, intended to fly on Pan Am 103 but had b... |
The German anti-terror campaign Operation Autumn Leaves (see J, O and P) led to the arrest of bomb-maker Marwan Khreesat weeks before the Lockerbie disaster. Khreesat was released after a few days because of a lack of evidence. In April 1989 further German police raids resulted in the discovery of two more bombs design... |
Two coach-loads of officials arrived at the disaster scene in the day after the crash. Many were plain-clothed Americans with no obvious affiliation. Among their baggage was a single coffin for which no explanation has ever been given. Labour MP Tam Dalyell later produced evidence indicating that the Americans had "sto... |
Lockerbie farmer Jim Wilson found a suitcase full of cellophane packets containing white powder among the debris in his fields. The suitcase was taken away, no explanation was given, and the authorities continued to insist that no drugs (apart from a small quantity of cannabis) had been found on the plane. But it was l... |
Ten days after the Lockerbie disaster, the Daily Express devoted its front page to exposing a Lebanese American called Khaled Jafaar whom it named as the "bomb carrier". The Express's sources were "the FBI and Scotland Yard". The Interfor report (see I) also named Khaled Jafaar as the bomb carrier. |
It has been argued that talk of the CIA, cover-ups, bombs, timers and Maltese trousers (see M) is just entertaining fiction. Some observers believe that there was no bomb on Pan Am 103 and that explosive decompression or an electrical fault caused the Lockerbie disaster, as they caused other Boeing 747 crashes. |
Paul Channon, British Secretary of State for Transport, lunched five journalists at the Garrick Club three months after Lockerbie and told them, off-the-record, that the Lockerbie killers had been identified and would soon be arrested. Yet the two Libyans who came to be the prime suspects were not charged until Novembe... |
Sixteen days before the disaster, a man rang the US embassy in Helsinki, Finland, and warned of a bomb aboard a Pan Am aircraft flying from Frankfurt to the US. The 1990 US President's Commission report on aviation security said that "thousands of US government employees saw the Helsinki threat". Not a single US worker... |
A report by Interfor, a New York corporate investigative company hired by Pan Am, suggested that a Palestinian gang (see P) had got the bomb on to the airliner at Frankfurt by exploiting a US intelligence deal (see U). In a bid to free American hostages in Beirut, American intelligence agents had apparently struck a de... |
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