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The state with the biggest problem with pharmaceutical misuse? Tassie. 5.6 per cent of Tasmanians misused prescription or over-the-counter drugs, the report found. |
The AIHW report comes ahead of a crackdown on codeine. From 1 February, 2018 codeine will no longer be over-the-counter. If you want it, you’ll have to get a doctor to prescribe it. |
Last year rapper 360 told Hack about his struggles with codeine addiction. |
His story prompted a flood of responses from our listeners. |
The Federal Government has also announced it will push ahead with its plan to drug test welfare recipients in three trial sites across the country. |
Up to 5,000 people who get Youth Allowance or the dole will be tested for drugs including cannabis, ice and ecstasy. Prescription drugs will not be included. |
COLUMBUS – An Ohio Supreme Court decision is expected soon that could impact the amount of financial compensation child sexual abuse victims can receive. |
Jessica Simpkins was raped at the age of 15 by her church pastor – a man hired by Grace Brethren Church in Sunbury despite the knowledge that he had previously sexually abused two girls. |
In a civil suit, a jury awarded Simpkins $3.5 million for pain and suffering, but the amount was reduced to $250,000 due to a state law that caps damages. |
She says she’s being re-victimized and took the case to the Ohio Supreme Court. |
Simpkins’ attorney argues the law is unconstitutional as applied to juvenile sexual abuse victims, as they can suffer more emotional damages than physical or economic harm. |
But attorneys for the church maintain large awards on non-economic injuries are subjective and difficult to quantify. |
Arguments were heard in December and a decision is expected any day now. |
Sexual assault victims often face a long, hard road of recovery, and Simpkins says she can’t get over the horror of her attack. |
Some supporters contend caps benefit the state’s economy by creating a fairer and more predictable civil justice system. |
But Simpkins’ attorney, John Fitch, says it’s bad public policy that shields those who engage in the sexual abuse of children. |
Heidi Allen was elected MP for South Cambridgeshire on May 7th 2015 with 31454 votes, taking 51.1% of the vote. |
Heidi has a background as manager and a wide business knowledge. Since 2009 she has been the managing director of the manufacturing business started by her parents in 1978. Within the years she has been able to develop it from what was an UK orientated company into one that now exports products all over the world. |
Heidi comes from a rural village in Yorkshire called Notton, and has studied Astrophysics at the University College London. |
Silver Wings: The Merle Haggard Tribute Show will perform at 7:30 p.m. Saturday in the Coolidge Theatre at the Deane Center for the Performing Arts (104 Main St. in Wellsboro). |
Performing in Wellsboro will be singer Andy Crawford, bassist Dan Broad, guitarist Dana Welts, pedal steel guitarist Pete Adams, drummer Vinnie Brandi and keyboard player Tony Torra. |
Silver Wings was formed in 2016, the year of Merle Haggard’s death at his home in Palo Cedro, California, on April 6 — the morning of his 79th birthday — from complications of pneumonia. |
Admission for Saturday’s show is $25 ($20 for seniors 65 and older or free for children 12 and younger when accompanied by a paying adult). For tickets, call 570-724-6220 or go online to deanecenter.com. |
Did AbbVie Blow $21 Billion Buying Pharmacyclics? |
A new competitive threat could imperil Imbruvica's fast growth as a treatment for a life-threatening cancer. |
Facing the loss of patent protection on its top-selling drug, AbbVie (NYSE:ABBV) forked over $21 billion earlier this year to buy Pharmacyclics and its blood cancer drug Imbruvica. Imbruvica's sales are surging, but late-stage trials are under way for a next-generation therapy that targets cancer in the same way as Imb... |
Imbruvica, a BTK inhibitor that targets a signaling molecule that is responsible for B-cell cancer cell survival and that was co-developed by Johnson & Johnson (NYSE:JNJ), is reshaping how doctors treat mantle cell lymphoma, Waldenstrom's macroglobinemia, and chronic lymphocytic leukemia (CLL). |
Mantle cell lymphoma and Waldenstrom's aren't common, but there are 15,720 cases of CLL diagnosed in the U.S. every year and that makes that indication most interesting to investors. |
Historically, CLL patients have been treated with chemotherapy and/or Rituxan therapy, but chemotherapy is highly toxic and it can cause life-threatening side effects that make it far from an ideal treatment. Fortunately, following robust efficacy in trials studying Imbruvica's use in recurring CLL, doctors have increa... |
That shift in treatment may accelerate too as Imbruvica recently aced a late stage study evaluating its use in newly diagnosed CLL patients. In that trial, Imbruvica monotherapy reduced a patient's risk of death by 84% when compared to the chemotherapy chlorambucil. |
Based on those results, AbbVie and Johnson & Johnson filed an application for approval in newly diagnosed CLL patients in September and if the FDA approves Imbruvica in that indication, then industry watchers estimate the widespread use of Imbruvica could turn this drug into a multibillion-per-year megablockbuster. |
In order to deliver on industry watcher's lofty sales projections, Imbruvica may have to fend off competition from acalabrutinib, a drug that works similarly to Imbruvica and that is being developed by the privately held Acerta. |
Like Imbruvica, acalabrutinib targets BTK to disrupt disease progression, but acalabrutinib could have a distinct advantage over Imbruvica because it more specifically targets BTK. |
Despite Imbruvica's efficacy, the drug has been shown to impact non-BTK targets, such as EGFR, and it's thought that Imbruvica's off-target activity is why some patients suffer adverse events, including atrial fibrillation, that leads them to discontinue therapy. Off-target activity may also lead to cancer mutation, su... |
Recently, Acerta reported clinical-stage data for acalabrutinib in 60 CLL patients that appears to support the idea that this drug works better than Imbruvica. |
Specifically, 95% of relapsed CLL patients who have received at least one prior therapy responded to acalabrutinib, including 100% of hard-to-treat patients who have the 17p13.1 deletion variation of the cancer. Moreover, there were no cases of Richter's transformation in the trial, and only one patient saw their disea... |
Additionally, acalabrutinib's safety profile appears to be best-in-class. Most adverse events were grade 1 or 2 and resolved over time. Only 2% of patients suffered grade 3 or grade 4 diarrhea, which is about half the percentage that has been observed in Imbruvica's trials. Also, no cases of atrial fibrillation or hemo... |
Given Acerta's trial results, it's not surprising that AstraZeneca plc (NYSE:AZN) is spending $4 billion to buy a 55% stake in the company. That deal, which was announced last week, includes $2.5 billion upfront to Acerta, plus another $1.5 billion conditional payment that will be paid upon regulatory approval of acala... |
has confirmed it's in talks to acquire it in a deal that could be valued at $5 billion or more. |
However, before AbbVie investors panic too much, they should remember that Acerta's trials are ongoing, and that its trial only included a small number of people, so it's far from certain that acalabrutinib's results will hold up in larger, later-stage trials. |
Nevertheless, strong efficacy and a potentially better safety profile could make this a big threat to AbbVie and Johnson & Johnson's Imbruvica, and that means investors should keep tabs on Acerta's ongoing trials, including a phase 3 trial in which acalabrutinib is being studied head to head against Imbruvica in 17p de... |
General Services Administration officials last week informally notified Sprint of plans to move all agencies to AT&T's portion of the FTS 2000 network if Sprint does not decrease its prices to a level comparable with AT&T's. |
John Okay, deputy commissioner of GSA's Federal Tele-communications Service, said last year's recompetition between the two FTS 2000 vendors resulted in a substantial difference between the rates AT&T and Sprint charge agencies for long-distance service. And users of the more expensive Sprint service have been complain... |
"The differential is so great that neither we nor our customers are satisfied with it," Okay said. |
A Sprint customer at the Justice Department, who asked to remain anonymous, confirmed that users there are "not happy with the pricing or the service." He declined to elaborate on specific problems with the service. |
Okay said nothing in GSA's contract with Sprint prevents the government from pulling all the traffic off the network. "Our authority under the original contract language is such that we can pull traffic off. We don't want to do that, but that is our fall-back position." |
Jim Payne, Sprint's assistant vice president for FTS 2000, said he would be willing to negotiate with GSA for lower rates, but he added that AT&T's tariff filing on its FTS 2000 rates was extremely "obscure." |
"We will continue to do the right thing by the customer, and we intend to fully support FTS 2000," Payne said. "But we need to know the government's expectations." He added that GSA's request for lower rates came as no surprise. |
John Doherty, AT&T's vice president for FTS 2000 and civilian markets, said GSA has not officially contacted him concerning the possibility of taking on Sprint's users. |
Sprint currently provides service to Justice, the U.S Courts, 800-service users at the Department of Veteran Affairs and other smaller agencies. |
The famous ship lying on the ocean floor is being eaten by bacteria. |
The mystery surrounding the great ship Titanic endures, but the days of the wreck itself are numbered. |
The CBC's Tom Murphy finds out what's eating the ship. |
The nation's largest and most expensive destroyer headed out to sea Monday for final builder trials before being presented to the Navy for inspection. |
BATH, Maine (AP) — The nation's largest and most expensive destroyer headed out to sea Monday for final builder trials before being presented to the Navy for inspection. |
Engineers and technicians at Bath Iron Works are going to focus on propulsion, mobility and safety to ensure the future USS Zumwalt is shipshape before the next trials, in which the Navy will perform a pre-delivery inspection. |
Rear Adm. Peter Fanta, director of surface warfare, said he likes what he has heard from the ship's commanding officer during the first trials in December. |
"He was extremely impressed with the stability of the ship, particularly in hard turns, particularly in its seakeeping ability," he told The Associated Press. |
The 600-foot ship is unlike anything ever built for the Navy. It features an angular shape to deflect enemy radar, a wave-piercing "tumblehome" hull, composite deckhouse, electric propulsion and new guns. Automation allows it to operate with a smaller crew than existing destroyers. |
But those innovations come at a high cost. The Zumwalt, the first of three ships in the class, will cost at least $4.4 billion. |
The price ballooned to the point some in the Navy tried to kill the program. Instead, the program originally envisioned for 32 ships was truncated. |
The ship, which will be based in San Diego, stands to play a role in the Obama administration's "rebalance" of resources to Asia and the Pacific, where China is flexing its military muscle in the South China Sea. But Fanta said he'll want a full assessment of capabilities before determining exactly how the ship will be... |
More than 200 Bath Iron Works employees and Navy personnel are participating in the builder trials to prepare the ship for delivery to the Navy. The ship is due to be commissioned into service in October. |
After the Navy takes delivery, there will be even more assessments, including rough-weather tests to determine the performance of the unusual hull that gives the ship a pyramid shape. |
"We go to find the most miserable places in the ocean and drive at various sea stages," Fanta said. |
The Navy believes it knows how the ship will perform, but it won't know for sure until all tests are completed, he said. |
The departure of the warship in the midst of a snowstorm on Monday marks the second time the ship has gone to sea. |
The "alpha" trials in December, which gave engineers their first opportunity to test systems at sea, were deemed a success even though repairs were needed on one of the ship's 12 motor drives. |
YOU don't stump John B. McLendon Jr. on basketball questions very often. With his 83d birthday next Sunday, McLendon, a pioneer and Hall of Fame coach, has forgotten more basketball than most coaches ever learn. |
From 1933 to 1936, McLendon studied under James Naismith at the University of Kansas. He was a member of the first class to receive degrees in the physical education department that Naismith began. He then learned basketball philosophy from Phog Allen, mostly by talking to the coach's players, and even coached a local ... |
McLendon coached at North Carolina College, Hampton and Kentucky State as well as for the Cleveland Pipers and the Denver Rockets. His Tennessee State teams, known for innovative fullcourt-press defense and fast-break offense, integrated the National Association of Intercollegiate Athletics and won three straight N.A.I... |
So much knowledge. But now McLendon was stumped. Before last night's game between Kentucky and Utah, someone asked him to pick the best player in this Final Four. His hesitation in large part was a tribute to a tournament in which no player had so far stood above his team. But there was a player, McLendon said, who had... |
''I can't think of a favorite player,'' he said. ''But I'll tell you this, what I like about that No. 15 from Kentucky is that when you call his number, he delivers. That's always been my favorite kind of player. He makes them go.'' Talent and skill are timeless. McLendon's No. 15 is Kentucky's Jeff Sheppard, a 6-foot-... |
Kentucky called Sheppard's number 14 times last night and he delivered. He scored 16 points as the Wildcats rallied from a 10-point halftime deficit and defeated Utah, 78-69, to win the national title. Sheppard, who added 3 assists, 4 rebounds and 2 steals, was named the Final Four's most outstanding player. |
But for most of the first half, Utah had his number. With Drew Hansen hanging all over him, Sheppard's slashing drives off the screen and 3-point shots were negated. But in the second half, with Kentucky floundering, Sheppard and Heshimu Evans led the Wildcats back. Rather than forcing outside shots, Sheppard took what... |
On this night, Sheppard's number was called on defense. With 7 minutes 12 seconds left to play and the score tied, 58-58, Sheppard intercepted a cross-court pass and scored to give Kentucky its first lead since early in the game. Two minutes later, Sheppard's short jumper gave the Wildcats the lead for good. |
On Saturday, with Stanford piling up a commanding lead in the semifinals, Sheppard led a defense that forced bad passes and rushed shots. That was not all. After Kentucky missed 10 of 12 shots from 3-point range, Coach Tubby Smith, ripping a page out of McLendon's book, called Sheppard's number. He delivered. |
After forcing a Stanford turnover in overtime, Sheppard made a driving layup that gave Kentucky a 76-73 lead with 4:04 to go. Then he connected from 3-point range, hitting from the top of the key to put Kentucky up, 82-78, with 1:24 to go. He added a free throw with 15.4 seconds left for Kentucky's final point. |
Things have worked out for Sheppard. He has played the role of hero. Last night he was a champion. Sheppard has undergone a great transformation from ultraserious, ultratight freshman to confident fifth-year senior and team leader. John B. McLendon Jr. knows him as No. 15. The guy who delivers. |
Top Volkswagen officials knew about the company's "dieselgate" emissions-cheating software at least a month before they claim to have discovered the scandal, German media reported on Tuesday. |
[BERLIN] Top Volkswagen officials knew about the company's "dieselgate" emissions-cheating software at least a month before they claim to have discovered the scandal, German media reported on Tuesday. |
VW looks set to pay US$4.3 billion (S$6.2 billion euros) to settle a US criminal case after admitting to fitting out 11 million diesel cars worldwide with software that reduces emissions under testing to pass controls, but then switches off under real driving conditions. |
That meant they released up to 40 times the permitted pollution levels. |
Previously, VW claimed that former group chairman Martin Winterkorn was only made aware of the issue in late August to early September 2015, just before the scandal broke out in September 2015. |
But newspaper Sueddeutsche Zeitung and regional television channels NDR and WDR claimed that two "crucial witnesses" have told US investigators that both Winterkorn and current group chairman Herbert Diess knew about the circumvention software "from the end of July 2015". |
"The directors took no measures to inform American authorities about these manipulations", wrote Sueddeutsche Zeitung on its internet site. |
Of the up to 11 million vehicles affected, 600,000 were in the US alone. |
Although Volkswagen admitted to installing the software, Mr Winterkorn denied responsibility. |
According to German media, one of the two witnesses was the head of the manufacturer's diesel service and told US authorities about the cheating software in August 2015. |
Despite the scandal, VW Group - which includes the brands Audi, Porsche and Skoda - said on Tuesday it had sold a new record 10.3 million cars worldwide last year. |
The latest revelations came just 24 hours after a former Volkswagen executive was charged with fraud and conspiracy. |
Oliver Schmidt, who ran VW's US regulatory compliance office from 2012 to March 2015, is accused of lying to US regulators. |
Volkswagen has already settled civilian charges related to the scandal, agreeing to a US$14.7 billion payment that allows nearly 500,000 vehicle owners to sell back their cars or get them fixed. |
Scotty McCreery's latest single "This Is It" was inspired by his new bride, Gabi Dugal, so it was only fitting that the song's lyric video pay homage to the newlyweds. The nearly four-minute clip, created and produced by McCreery’s label Triple Tigers Records, transports viewers to the scenic mountains of North Carolin... |
Throughout the video a range of couples can be seen hiking in the mountains, bike riding together and sharing a kiss by the picturesque backdrop. "This Is It" was written by McCreery, Frank Rogers and Aaron Eshuis. It is the second single off the singer's latest album, Seasons Change. |
While McCreery and Gabi are currently honeymooning in Tahiti, fans are invited to comment on the lyric video so the couple can read their fans' thoughts upon their return. Several fans have already shared their praise for the sweet ballad and its accompanying video on social media. |
"Love what you have done here!" one fan writes. "You have exquisitely expressed your excitement to be together forever! God Bless your marriage! Thank you for sharing so much of yourselves with fans who adore you! Such a pleasure to witness the joy you see in each other!" |
Meanwhile, another, admits that the song got her all kinds of emotional: "I've watched it a few times and each time I end up crying. Scotty, you know how to touch my soul with your songs," Gloria writes. |
The former classmates, who met in kindergarten, were married on June 16, in the mountains of their home state in front of 200 of their family and friends. Dugal wore a gown by Morilee for a ceremony that was officiated by McCreery's childhood pastor and during which the couple exchanged vows they had written, People re... |
Yes, Scotty Asked Her Parents! |
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