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Mar 11, 2013 Anti-Aging Drug Breakthrough: Can Humans Live to 150? |
Timberline Wolves boys camp: For grades 9-12, 6 to 8 p.m. Monday-Thursday; grades K-5, 12:30 to 2 p.m. June 8-10; and grades 6-8, 2:30 to 4 p.m. June 8-10. Cost is $60. Call Bruce at 870-4545. |
Crossings Winery Cup tournament: 8:30 a.m. Saturday at Three Island State Park. Cost is $20-$40, plus a $5 motor vehicle entry fee. Ticket includes lunch provided by Corssings Winery and a free concert by Barton & Bollar. Go to crossingswinery.com/category/special-events. |
Optimist Youth Football and Cheer: Signups for flag for ages 6-8, tackle for ages 8-12 and cheer for ages 4-12, 6 to 9 p.m. Thursday at Capital High. Late signups from 9 a.m. to 1 p.m. June 20. Preregister at optimistyouthfootball.com. |
The Village Fun Run/Walk: 5:30 p.m. Wednesday at The Village at Meridian. Free. Go to fleetfeetmeridian.com/fun-run. |
Touchmark Hawaiian themed fun walk/run: 9 a.m. May 27 at Touchmark at Meadow Lake Village. 1 or 3 mile walk; 5k fitness walk/run. No preregistration required. Call 288-2277 with questions. |
YMCA Middle School/Junior High Regional Championships: For grades 6-8, Saturday at Mountain View High. Contact Jack at 344-5502, ext. 270; jack.ward@ymcatvidaho.org or go to team-idaho.org. |
Virginia Republicans lack a consensus frontrunner to take on Sen. Tim Kaine Timothy (Tim) Michael KaineOnly four Dem senators have endorsed 2020 candidates Democratic proposals to overhaul health care: A 2020 primer Dems ask Justice Dept to release findings of Acosta-Epstein investigation MORE (D-Va.), setting the stag... |
Republicans fear that the campaigns of two controversial figures — minister E.W. Jackson and frontrunner Corey Stewart, chairman of the Prince William County Board of Supervisors — will wind up alienating moderates and squandering any long hopes Republicans had of winning in a state that's increasingly trending blue. |
And even if state Delegate Nick Freitas is able to catch fire, most Republicans and analysts don’t think he’ll have a real shot against Kaine, either. |
Stewart is the favorite in the GOP primary, after leading the field in the only public poll of the race, released in February. But the vast majority of voters in the poll were undecided, and all three candidates in the Christopher Newport University poll trailed Kaine by more than 20 points. |
Stewart raised his profile in the state after a surprisingly strong 2017 gubernatorial primary where he fell just short of former Republican National Committee Chairman Ed Gillespie by roughly 1 percentage point. That tough primary divided the state party, but Stewart showed he could appeal to the grass-roots Republica... |
Stewart made defending of Confederate statues a central piece of his campaign, wading into the highly charged debate by holding rallies outside of Charlottesville’s City Hall, where a statue of Confederate Gen. Robert E. Lee stood. |
That statue later became the site of the August far-right “Unite the Right” rally, where white supremacist groups joined to march in defense of the statues. One female counterprotestor was killed when a car was driven into a crowd, with a man connected to a white supremacist group charged in the case. |
Gillespie went on to lose the governor’s race by nearly 9 points, and the GOP came within a coin-flip of losing its majority in the state House of Delegates. |
Those 2017 defeats weigh heavily on the Senate primary. Republicans are shell-shocked by a blowout that was driven in part, according to exit polls, by President Trump Donald John TrumpForget the spin: Five unrefuted Mueller Report revelations Lara Trump: Merkel admitting migrants 'one of the worst things that ever hap... |
But Stewart sees the race differently. |
He told The Hill that Gillespie’s loss proved that Republicans couldn’t win Virginia with a “standard Republican.” Instead, he said, Virginia needs a candidate with a Trump-style “edge” like Trump. |
Stewart said he isn’t interested in unifying the party around him after the brutal 2017 primary. |
“You’ve got to be edgy, you've got to take risks. That, of course, attracts media attention. One thing I understand that I don’t think my Republican opponents get: the need to be controversial in order to attract media attention,” he said. |
“I’m a very aggressive campaigner, and I take no prisoners. I’m a ruthless, aggressive campaigner and that’s how I will run my race against Kaine,” he said. |
Stewart pointed to his success winning elections in Northern Virginia’s Prince William County as proof that he has a strong base. And while he distanced himself from white nationalists like Richard Spencer, who marched in Charlottesville, Stewart defended his decision to dive into the statue controversy as a way to mob... |
But Stewart is taking some primary fire of his own from Jackson, who kicked off his campaign announcement by accusing Stewart of having “dealings” with the Muslim Brotherhood, according to The Washington Post. |
Jackson’s 2013 lieutenant governor campaign was dogged by controversial comments about gay and transgender people, but he’s since sought to distance himself from those comments. |
Freitas, the state delegate, made a speech recently opposing gun control that’s gone viral on the right. As of Thursday, it had more than 16 million views on Facebook. |
Republicans described Freitas as a long-shot candidate with an intriguing profile. Freitas is a former Army Special Forces sergeant who served in Iraq, and he has the backing of Sens. Rand Paul Randal (Rand) Howard PaulDem super PAC campaign urges Republicans to back impeachment Booker, Harris have missed most Senate v... |
The Jackson and Freitas campaigns did not respond to a request for comment. |
Republicans and analysts reached by The Hill framed the race as virtually unwinnable for any of the candidates. Kaine has a massive fundraising advantage after ending 2017 with $9.2 million in the bank, compared to Stewart’s $175,000 and Jackson’s $14,600. Freitas will file his first fundraising report next week. |
And outside Republicans groups have mostly stayed out of the race, while five other Senate races have already drawn more than $1 million in outside spending, according to the Center for Responsive Politics. |
Kaine’s favorability has been strong — the Christopher Newport University poll found him with a 53 percent favorable rating, compared to only 35 percent unfavorable. More than 8 in 10 voters didn’t have an opinion on Freitas or Jackson, while Stewart sported a 13 percent favorable rating and a 20 percent unfavorable ra... |
With Kaine seen as such a heavy favorite, some Republicans are sounding the alarm about how a poor showing in the top-of-the-ticket Senate race could threaten down-ballot candidates. Virginia GOP Rep. Barbara Comstock Barbara Jean ComstockGOP lawmaker introduces bill to stop revolving door Ex-lawmakers face new scrutin... |
“A weak Republican candidate can take all three down,” Fredericks said. |
Newswise — Lake Nona, Fla., May 3, 2017 — New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona uncovers the modus operandi of a mysterious molecule called SPRIGHTLY that has been previously implicated in colorectal cancer, breast cancer, and melanoma. The findings, published in the jo... |
SPRIGHTLY is a type of molecule called long non-coding RNA (lncRNA). LncRNAs have long been regarded as junk because they aren’t translated into protein. However, in the past few years they have been linked to essential roles in the cell, and their misregulation has been linked to disease. |
Perera’s group has previously shown that SPRIGHTLY is present at higher levels in melanoma cells than in normal skin cells and that lowering levels of the molecule promotes cancer cell death. They have also found that the amounts of SPRIGHTLY and other lncRNAs are elevated in prostate cancer compared to normal tissue, ... |
LncRNAs bind to many cell components including DNA and protein. Perera’s lab decided to go a step further and investigate whether SPRIGHTLY makes contact with other RNAs in melanoma cells. |
The team used a technique that chemically crosslinks SPRIGHTLY to its neighbors, which revealed that SPRIGHTLY indeed bound to 115 RNA partners that code for proteins, six of them considered “major” partners. Interestingly, all six genes were already implicated in a variety of cancers. |
The scientists then used CRISPR/Cas9, a newer genomic modification method, to reduce SPRIGHTLY expression in melanoma cells, finding that the levels of most of its six major partners also decreased as a result. Reintroducing SPRIGHTLY normalized these levels, the group found. Moreover, in an immunocompromised mouse mod... |
The group is also interested in understanding SPRIGHTLY’s role in metastasis. In the new study, large data analysis of the relationships among SPRIGHTLY’s various RNA binding partners conducted by SBP collaborators Shaojie Zhang Ph.D., (University of Central Florida) and Animesh Ray, Ph.D., (Keck Graduate Institute in ... |
This work was supported by National Institutes of Health grants CA165184, NCI 5P30CA030199 and DP5 OD012160, and Florida Department of Health, Bankhead-Coley Cancer Research Program 5BC08. |
City Manager Michael V. O'Brien has come out with an ambitious $94.6 million five-year capital improvement plan that lays out the financing for reinvestment in the city's aging infrastructure, including its public streets, sidewalks, parks and school buildings. |
The plan calls for $30.7 million to repair and resurface streets and sidewalks, $44 million worth of building and energy improvements to public school buildings and $13.6 million in similar improvements to municipal buildings. |
Other major investments call for $1.85 million on parks, $2.21 million on equipment purchases, including new police cruisers, and the purchase of new computer software to improve the city's permitting process and property assessment operations. |
Mr. O'Brien said his capital recommendations are the result of a long-term analysis and strategic planning efforts, as well as priorities identified by the City Council. |
“We are all aware that our public school facilities and our streets and sidewalks are in great need of repair,” Mr. O'Brien wrote as part of his recommendation that goes before the City Council tonight. “These are, without question, our top infrastructure priorities, as cited time and time again by citizens and surveys... |
For the fiscal year that begins Thursday, the city manager has restored the borrowing cap for the capital program to $18.5 million. That is a $3.5 million increase over what it has been the past two years, when capital borrowing costs were limited to $15 million annually. |
Mr. O'Brien said $3 million of the $3.5 million increase in capital spending will be appropriated to the public schools for improvements to school buildings, such as bathroom upgrades, painting and carpeting. |
Because the capital budget has historically funded the public schools at $3 million, the manager said, lifting the borrowing cap to $18.5 million will effectively double the allocation for the public schools to $6 million. |
In addition, Mr. O'Brien's capital budget recommends $38.63 million in energy upgrades to school facilities over the next five years, including the installation of new state-of-the-art boilers, HVAC systems, energy controls, windows and insulation. |
He said much of the energy upgrades for the municipal and public school buildings will be supported through incentives, tax credits and the city's energy-savings contract with Honeywell International. |
•$30.7 million to repair and resurface streets and sidewalks. |
Of that, $27.7 million will be financed through the tax levy — including using $2 million from the city's tax-levy reserve — while the other $3 million will come from the proceeds the city received from the transfer of Worcester Regional Airport to the Massachusetts Port Authority. |
Over the five-year period, the city will be reinvesting nearly $20 million more to address the backlog of street and sidewalk repairs and reconstructions, said the manager, who added that has consistently been a priority of the City Council and residents. |
In addition to sidewalk and street resurfacing and repair, work under this program will include tree stump removal as needed, curb repairs, re-planting of trees when appropriate, new pedestrian crosswalks, new signs and all work conforming to federal accessibility laws. |
•The $1.85 million for parks improvements and open space acquisition includes $750,000 in proceeds from the transfer of the airport to support upgrades to Logan Field, Bennett Field and Spillane Field. The remaining money will be used for improvements to Green Hill Park, Crompton Park, and the Newton Square Veteran's M... |
•$750,000 to support economic and neighborhood development activity — $200,000 for building Faraday Street in accordance with the Gateway Park Master Plan, and $550,000 to rehabilitate and prepare space in Union Station for potential new tenants. |
Can the Indianapolis 500 find drivers and equipment fit enough to fill its traditional 33-car field? That is but one of the countless questions that have been raised by the feud ripping apart the racing world and landed most of the sports' biggest names in Brooklyn, Mich., this weekend for the U.S. 500 time trials. |
It is also one of the many questions Indianapolis Motor Speedway president Tony George addressed Thursday morning. |
"I don't know if we can ensure anything," he said. "But I don't believe the traditional 33 starting spots will be a problem filling." |
That was an expected stance for George, who split with CART (the sponsors of the U.S. 500) and formed the Indy Racing League. But here, after a pause, he unexpectedly (and cryptically) added, "The question is will we consider as we have in the past maybe expanding (the field). |
"Certainly we appreciate everybody's support to date, and trying to show our appreciation for the support, our minds are open to any number of things this year. . . . The possibility is always there to expand beyond the 33. As most people are aware, it was a topic of discussion at least earlier in the spring. |
"You know, 33 has been the tradition. But we started 35 in fairly recent history (1979). I don't know. I'm not suggesting anything other than this is an unusual year . . . (and that) anything is possible." |
Records to fall? Even without many stars on hand, Saturday's run for the pole is expected to produce record speeds. One reason for this is the Speedway's new high-density, hard asphalt track surface, which was laid last October and now has Scott Brayton, well, fairly excited. |
"Absolutely incredible," he says. "There's no other way to describe it. I can't put words to it. It's smooth with lots of grip. It's going to take us places we haven't been yet. I think you'll see a new track record without question. What it will be, I don't know." |
Arie Luyendyk set the track one-lap record Thursday at 237.774. Roberto Guerrero had had the one-lap record of 232.618, which he set back in 1992. But this week during practice, it had been broken unofficially by Tony Stewart (237.336), Eddie Cheever (235.997), Brayton (235.750), Luyendyk (233.621) and Buddy Lazier (23... |
Hangin' out: One of those who has just been hanging around the Speedway this week is 59-year-old Gordon Johncock, who last competed in the Indy 500 back in 1992. But next week, he plans to do more than that. He plans, in fact, to look for a ride. |
"I bought a new John Deere tractor," he explains, "and I can't pay for it raising cattle." |
Tidbits: The largest number of rookies to start an Indy 500 was 19 way back in 1919. At least 13 will be looking to qualify on Saturday and that number could grow. . . . The youngest rookie ever to start an Indy is Josele Barza, who was 19 years and 70 days old in 1981. If he qualifies for this year's field, Michel Jou... |
What can China teach the U.S. about IT security? |
One of the most interesting pieces of information to come out of McAfee’s second annual critical infrastructure protection report is the apparent connection between the amount of interaction companies have with their governments and their level of IT security. |
“The report indicates a strong correlation,” McAfee CTO Phyllis Schneck said. Companies reporting frequent interaction and regular security audits, especially those in China and Japan, had a higher percentage of security measures implemented on their systems than companies in market-driven economies such as the United ... |
“Based on these figures, if there is a race among governments to harden their civilian infrastructure against cyberattack, Europe and the United States are falling behind Asia,” the report states. |
Unfortunately, Schneck added, “it is not quite defined what that relationship should be,” to obtain optimal security without compromising freedom. |
The report, released last week in Washington, was based on a survey of 200 industry executives from critical infrastructure enterprises in 14 countries. The data was analyzed and supplemented by the Center for Strategic and International Studies. |
In an effort to get more specific data, executives were asked about a list of 21 specific security controls, from patch and configuration management to application whitelisting and monitoring network connections. Nobody was doing everything that could be done, but China, Italy and Japan were at the top of the list, hav... |
Executives in both countries also reported regular government audits of their security status, which was almost nonexistent in the United States. |
“The companies that have the most interaction with government about security have begun to have more respect for each other and take the threats seriously,” said Stewart Baker, visiting fellow at CSIS and former assistant secretary of Homeland Security and counsel to the National Security Agency, in a panel discussion ... |
So what does this mean for us? Government and industry have for years acknowledged that protecting the nation’s critical infrastructure requires a public-private partnership, but finding the right balance has been difficult. The private sector owns and operates the infrastructure, and government has the responsibility ... |
But the message seems to be that government has an important role to play, if leaders only knew what it is. |
“I don’t see a magic formula,” Schneck said. |
Few would seriously propose that the United States adopt the security policies of China. But there are cultural as well as political differences between this country and Asia, and a non-regulatory relationship seems to produce results. |
U.S. executives and government officials might not have the same attitude toward a partnership as their Japanese counterparts, but there might be something we can learn from them. |
The "Star Wars" actress struggled with drug addiction and bipolar disorder. |
Carrie Fisher, a longtime advocate for mental health issues, opened up about her own battles just a few weeks before her death in her advice column in the British newspaper The Guardian. |
The "Star Wars" actress, who openly spoke about her struggles with drug addiction and bipolar disorder, told a Guardian reader in a column dated Nov. 30, 2016, about the importance of finding communities of other bipolar people. |
"I was told that I was bipolar when I was 24 but was unable to accept that diagnosis until I was 28 when I overdosed and finally got sober," Fisher wrote. "Only then was I able to see nothing else could explain away my behavior." |
"Going to AA helped me to see that there were other people who had problems that had found a way to talk about them and find relief and humor through that," she wrote. |
"Initially I didn't like the groups. I felt like I had been banished to sit with a group of other misfits like myself to sit still for an hour. But then someone said, 'You don’t have to like these meetings, you just have to go, go until you like them.' That took me by surprise," she wrote. "I didn’t have to like someth... |
"You don’t have to like doing a lot of what you do, you just have to do it," Fisher told the reader. "As your bipolar sister, I’ll be watching. Now get out there and show me and you what you can do." |
Fisher died this morning at age 60. The actress was rushed to the hospital Friday after going into into cardiac arrest while aboard a flight from London to Los Angeles. |
In 2000, Fisher opened up to ABC News' Diane Sawyer about her past drug use including cocaine, acid and heroin. While filming the 1981 film "Under The Rainbow," Fisher said, "I was completely crazy. ... I was on drugs, I started losing a lot of weight. ... I was not sleeping. I had a seizure on the set." |
Regarding her mental illness, she told ABC News in 2000 she grew to "own it." |
"I'm mentally ill," she told Sawyer. "I have a chemical imbalance that in it's most extreme state will lead me to a mental hospital." |
In 2001, Fisher spoke about mental health at a rally in Indianapolis, Indiana, to advocate for increased state funding for addiction and mental illness treatment. |
"Medication has made me a good mother, a good friend, a good daughter," she told the crowd of nearly 2,000, according to The Associated Press. |
For Fisher, daughter of "Singin' in the Rain" actress Debbie Reynolds and singer Eddie Fisher, life was always in the public eye; she told CBC Radio Active this September that "anything that's been a challenge for me has never been a secret." |
"I went into rehab when I was 28 years old, and then I was diagnosed as being bipolar," she told CBC. "Because I grew up in a public family, I never really had a private life. And so if those issues are going to be public, I would rather them to be public the way I've experienced them rather than someone else assuming ... |
Judge Loretta Murphy Begen continued the arraignment until Dec. 11. |
She also took steps she said are aimed at ensuring a fair trial. She sealed an affidavit that outlines the grounds for Porter's arrest. She ruled that Porter can wear street clothes in court. And she banned cameras from the courtroom. |
Defense attorney Kirk McAllister said such restrictions are needed "to enhance the chances of our being able to try this case in this county." |
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