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both strategic and financial grounds." We do not profess to be able to say offhand whether this new plan of making a strategic centre of the Far East, for that is what it amounts to, is right or wrong, but we assume that the Government has considered the matter most carefully in all its lights before coming to a decisi... |
If you’ve been holding out hope that we might see the Shrek franchise return to the big screen, we have some good news. This year marks the 15th anniversary of the original DreamWorks Animation film featuring the voices of Mike Myers, Eddie Murphy and Cameron Diaz, and to celebrate the milestone, the studio is figuring... |
Illumination Entertainment has a couple of new animated movies hitting theaters this year. The first is the animal adventure The Secret Life of Pets, arriving this summer. But just before Christmas, Illumination will get musical with Sing. In what is basically Zootopia meets American Idol, one koala (Matthew McConaughe... |
If the Minions aren’t your cup of tea, then maybe you’ll be more interested in one of Illumination Entertainment’s other projects coming this year. The Secret Life of Pets is the next one from the animation studio arriving this summer, but just before Christmas this year, they also have the musically charged Sing. |
Winter is slowly but surely inching to an end, so let’s look ahead to what the next season has in store for us. The next few months promise to be an interesting one for indie releases, as both Spring Breakers and Zal Batmanglij‘s The East are slated to open. |
Further down the road, The Weinsteins are getting into the paranormal YA game next winter with Vampire Academy, and Universal’s Untitled Illumination Entertainment Project (not the final title, obviously) has been slotted for summer 2015. Hit the jump for all the details, in chronological order. |
Briefly: Ron Howard and Jim Carrey’s live-action version of How the Grinch Stole Christmas, from 2000, isn’t the most beloved movie out there — why watch that one when the original Chuck Jones animated version is so much more charming? — but it does have fans, and it made money. |
But The Lorax made more money, and so now Universal, Chris Meledandri, and Illumination Entertainment are going to make a new 3D animated version of the Dr. Seuss classic How the Grinch Stole Christmas, to follow up on Illumination’s other Seuss adaptations. Deadline says that Meledandri is producing with Pete Candelan... |
But if they were 24 fans like me, Id hope they welcomed everybody! |
Other than that, Stevenson Ranch is a REALLY nice place, quaint, tucked away, and safe! perfect for raising a family. |
The best suburb of LA County in my opinion! |
July 15, 2012 at 1 a.m. |
Updated with information on early release Friday. |
All Edmonds School District schools will start on time Friday, Feb. 8, but will be released early in response to the predicted snow storm. Early release times for schools can be found at bit.ly/ESDStartDismiss. |
The district has also announced the dates for making up the two school days lost to snow-related closures this week. |
Your kidneys are two vital organs that keep you alive by filtering your blood of waste and excess toxins. These small organs are delicate yet they are protected within your body. However, there are times when you can bruise your kidney from a sports injury or car accident. The Merck Medical Foundation says your body ma... |
Sleep for 10 hours each night. Bed rest is required for a bruised kidney. You need to sleep often and for long periods of time. Keep your body still and find a comfortable position. Take naps during the day and eat healthy foods that are rich in vitamins to promote healing. Raw fruits and vegetables are excellent optio... |
Take a hot bath. Fill the tub with hot water and Epsom salts. The heat will help you feel better and ease the pain. |
Take ibuprofen or an anti-inflammatory drug prescribed by your doctor. Usually a bruised kidney does not require stronger pain medications unless the injury is severe or if you are dealing with other internal injuries as well. |
Drink eight to 10 glasses of purified water each day. If you are suffering from a bruised kidney you may notice blood in your urine. Your kidneys need additional support during this time, so be sure to drink a lot of pure water each day. If you work out or spend time in the sun you may need even more water. |
Place a heating pad or ice back on your bruised kidney. Some people prefer cold over hot so use either one depending on your individual preference. Lie down while doing this and try to relax. |
Take additional vitamin C, D and A to help speed the healing process. |
The most common signs of a bruised kidney are blood in the urine along with pain and swelling. Sometimes people with a bruised kidney will also feel nauseous as well. |
If you are passing a lot blood you may need to hospitalized and monitored closely. The kidneys are delicate and you may need to avoid working or moving around too much so that your body can heal faster. Sometimes surgery is needed if the damage is severe.Car accidents can cause damage to the kidneys that can result in ... |
Pet treats brand Milk-Bone wants to show the world “through a dog’s eyes” in a documentary airing on the Public Broadcasting Service’s network of TV stations this spring. |
“Through a Dog’s Eyes,” as the documentary is called, shows what happens when service dog recipients are matched with their canine companions for the first time. The one-hour episode, a collaboration between production houses TPT and Partisan Pictures, chronicles the two-week journey of several people: Bryson Carey, a ... |
Milk-Bone, a 12-year sponsor of Canine Assistants (a nonprofit that provides service dogs to physically disabled individuals), is not featured in the documentary. But the brand is running a 30-second spot at the beginning and end of “Through a Dog’s Eyes,” which airs on April 21. |
“The Milk-Bone brand, at its core, is all about being genuine and nothing is more genuine than service dogs providing benefits to people who need them,” Fleming said of the “driving force” behind the documentary. |
“Through a Dog’s Eyes” will feature segments like a visit from Dr. Adam Miklosi, the “world’s expert on human-canine bonds,” said Naomi Boak, an executive producer at TPT National Productions, the production arm of PBS affiliate, TPT, which worked on the launch. To promote the launch, PBS will also feature the Milk-Bon... |
Del Monte Foods upped its ad spending on Milk-Bone from $600,000 in 2008 to $7.6 million through the first 11 months of 2009, excluding online, per the Nielsen Co. The increase is partially attributed to the brand’s return to TV advertising with the “It’s Good to Give” campaign in September. |
The new drug dilemma: Does big pharma have a duty to humankind — or its shareholders? |
MONTREAL — There’s a chart executives with Quebec’s Valeant Pharmaceuticals International Inc. like to show proving what a mess global drug development has become. |
It’s a stunning fact. And the pharmaceutical industry has been scrambling for a way to address it ever since. |
With such a dismal record, do big pharmaceutical companies still have a moral duty to try to discover drugs that better and save people’s lives or is their first imperative to make money for shareholders? And just how much research spending is worth it anyway? |
Recent industry activity like Pfizer Inc.’s play for AstraZeneca and Valeant’s US$53-billion run at California-based Allergan Inc., the maker of Botox, have made these questions all the more urgent. Valeant’s move in particular has touched a nerve. |
That’s because there is perhaps no bigger corporate penny-pincher than J. Michael Pearson. |
The chief executive of Laval, Que.-based Valeant has built the entire company on the premise that research is largely a waste of money. His business model, which has turned Valeant into a US$42-billion company: Hunt aggressively for firms with proven products already on the market, (think eye care and skin remedies) an... |
Supporters say Mr. Pearson’s approach, hatched over 20 years as a pharma industry consultant with McKinsey & Co., is the logical end game of an industry that has squandered billions. To them, it’s a wonder more companies haven’t mimicked what Valeant has done. |
Detractors charge that Valeant is more a marketing company than a true drug and health product producer and that it will implode when it runs out of takeover targets. They fret that if Valeant’s model goes mainstream, drug discovery will die. |
Bill Ackman, the billionaire activist investor whose hedge fund Pershing Square is partnering with Valeant on the Allergan deal, said it’s shocking that big pharma executives were once paid based on the volume of R&D they did. |
Valeant does do research and development, just not any of the early-stage, high-risk stuff. The company last year spent about 3% of its revenue on R&D versus roughly 15% for the industry, according to analysts. It projects it will spend between US$250-million and US$300-million this year on research versus Allergan’s U... |
Three hundred million may seem like a lot of money until you realize, as one observer noted, that cigarette-maker Philip Morris spent US$449-million on R&D in 2013 and they pretty much just roll tobacco. |
Yet it’s not strictly about how big your research budget is. |
Valeant’s take on the US$9.5-billion Allergan has spent over the last 16 years bringing Botox and other products to market is that it could have achieved the same result by spending far less. It’s what Mr. Ackman calls Valeant’s “platform value,” or its operational efficiency. |
Mr. Pearson is right when he says most pharmaceutical drug R&D is wasted money, says Bernard Munos, an influential industry consultant who’s long been calling for radical change in the way companies do research. But he says that doesn’t mean doing R&D is inherently unproductive and can’t be done in a better way. |
By largely abandoning research and focusing on sales, Valeant is pursuing a model more akin to consumer merchandising, Mr. Munos said. |
“They want to end the mess that R&D currently is and replace it with something else, which as far as I understand it, is more like brand management of drugs that have already been approved,” Mr. Munos said. “It could work. But I also think that it will fall short of society’s expectation. And that is a dangerous thing ... |
“Because I mean you can manage a stable of brands successfully. But that is not going to solve Alzheimer’s. It’s not going to solve diabetes. It’s not going to solve the dearth of antibiotics. It’s not going to solve the great public health challenges that we face. And society pays our bills” by protecting drug patents... |
Industry has made progress on delivering more and better R&D innovation, Mr. Munos said, even if it’s slow improvement and still nowhere near where it should be. |
He points to GlaxoSmithKline Inc. as a company that has successfully revamped its R&D program. Research chairman Moncef Slaoui reorganized the company’s R&D system into 38 separate and small units of scientists that have to defend their progress and funding every three years. In the 12 months ending April 2014, Glaxo b... |
Another thing to consider as Valeant tries to buy Allergan is that mergers make it more difficult for the remaining scientists to discover new drugs, says John LaMattina, a former president of Pfizer Global R&D who now works for PureTech Ventures. |
In theory, consolidating two companies generates an opportunity to weed out weaker research. In reality however, the nature of drug discovery is such that it’s not obvious what the best ideas really are, Mr. LaMattina says. |
Where does Allergan fit in to all this? According to one study on R&D performance by Sector & Sovereign Health, the company ranks fifth among major companies, suggesting what it spends on research generates productive returns. |
Allergan’s chief executive, David Pyott, is widely credited with pushing Botox from its initial value as a treatment for crossed eyes and involuntary eyelid closure to the popular wrinkle fighter we know today. That required plenty of R&D dollars. |
The stock hasn’t suffered much as a result: It’s up fivefold since Mr. Pyott started. |
As the battle for Allergan heats up and as Valeant seeks more takeover targets in the months to come, the issue of pharma’s future will remain a burning one. |
Financial Times columnist John Gapper says industry leaders face a moral choice between two visions in the way they approach R&D. |
The real question, to me, is whether a given media producer is making those in power uncomfortable. That's the true, indispensable role of the press and really the only thing that matters. |
And, playing that role as if she were born to it, blogger Marcy Wheeler's Empty Wheel on FireDogLake, has, along with Josh Marshall's Talking Points Memo, been making as big an impact in breaking news as any blog out there. |
The real question, to me, is whether a given media producer is making those in power uncomfortable. That’s the true, indispensable role of the press and really the only thing that matters. |
And, playing that role as if she were born to it, blogger Marcy Wheeler‘s Empty Wheel on FireDogLake, has, along with Josh Marshall’s Talking Points Memo, been making as big an impact in breaking news as any blog out there. |
No less an authority than Jay Rosen considers Wheeler’s liveblogging of the Scooter Libby trial in 2007 one of the seminal moments in online journalism, and, in Jane Hamsher’s inimitable words, Wheeler has “consistently demonstrated the investigative skills that show what bloggers and those using online tools are uniqu... |
So Hamsher has launched a grassroots campaign to help fund Wheeler’s investigative work. She’s hoping to raise $150,000 to support Wheeler, another investigative blogger to work with her, and a researcher to help them. All money raised will go directly to those efforts. As of this writing, 1,038 people have so far cont... |
Gazprom has no reasons to worry about Ukraine siphoning gas destined for Europe as payment for a fine leveled against the Russian firm by Ukraine’s Antimonopoly Committee, explains CEO Aleksey Miller. |
“Let them dare!” Miller said on the sidelines of the 21st St. Petersburg International Economic Forum (SPIEF 2017) on Thursday. |
In December, Kiev’s Economic Court upheld a decision by Ukraine’s Antimonopoly Committee to fine Gazprom $6.6 billion, including over $170 million in penalties. The fine was imposed for alleged abuse of monopoly power in the natural gas market in 2009-2015. |
Miller refused to comment on the course of the litigation between Gazprom and Ukraine's state energy company Naftogaz, as a final decision is still awaited. |
Earlier this week, Naftogaz claimed the arbitration court in Stockholm had ruled in its favor in a dispute with Gazprom. The Russian company said the ruling was an interim stage in the court process. |
In 2015, Gazprom took Naftogaz to court demanding the Ukrainian company pay penalties over the failure to fulfill the 'take-or-pay' terms of its contract. Gazprom said the deal obligates Kiev to buy a minimum quantity of gas annually or face a penalty. |
As of the end of May, Gazprom’s claim totaled $47.1 billion, most of which – $34.5 billion – was for gas not delivered by the Russian company in 2012-2016. |
Earlier this year, the head of business development of Naftogaz Yury Vitrenko admitted that losing the case in Stockholm court would lead to the Ukrainian company filing for bankruptcy. |
Commander Barry Wilmore hands over command of the International Space Station to Terry Virts. |
American astronaut Barry Wilmore has checked mostly everything off his to-do list in space. |
With his bags packed and his crew quarters cleaned, Wilmore has officially handed over command of the International Space Station to American Terry Virts, who will oversee Expedition 43. |
Wilmore is spending his final hours in space before he hitches a ride with his co-workers, cosmonauts Alexander Samokutyaev and Elena Serova, as they travel back to Earth in Russia's Soyuz spacecraft. |
The group will begin undocking the Soyuz from the International Space Station today at 6:44 p.m. ET and land in Kazakhstan at 10:07 p.m. While the approximately 249 mile free-fall back to Earth takes about 45 minutes, the process for making sure they arrive at their destination is far more complex. |
The Soyuz will stay close to the ISS for about two revolutions of the Earth as it fires its engines to align with the landing site. The crew on board the spacecraft will then turn its de-orbit engines in the direction of travel and fire them for four to five minutes before falling back to Earth. |
The atmosphere helps slow the Soyuz down until parachutes open and help the spacecraft glide toward a landing. |
RAJKOT: Driven by the greed of usurping her property, a man allegedly killed his wife, a woman cop, in Sudama Park Society of Madhuram locality in Junagadh on Sunday night. The man and three of the deceased’s in-laws were arrested for the murder on Monday. |
The deceased Kiran Joshi (41), an assistant sub-inspector who was deployed with Junagadh C-Division police station, was transferred to Visavadar police station just two days ago. She had got married just five months ago. Police said Joshi was stabbed to death allegedly by her husband Pankaj Vegda, his elder brother Dip... |
In his complaint, Joshi’s brother Mahesh alleged that Pankaj and his family members wanted to usurp her house which was in her name. Pankaj, who was jobless, wanted to sell off Joshi’s property to start a business. However, as Joshi objected to this proposal, the seeds of discord were sown between the couple who fought... |
“On the fateful night, Pankaj along with the other accused barged into Joshi’s house and picked up a fight with her. They attacked Joshi with knives, stabbing her in stomach, throat and head, killing her on the spot. After committing the crime, they locked the house and fled. The neighbours informed Joshi’s family memb... |
Of the accused, Pankaj’s brother Dipak Vegda also serves as a constable with Junagadh police. Incidentally, Joshi’s father Kanu Joshi was a sub-inspector. |
Police have arrested the accused after booking them under sections 120 (B), dealing with conspiracy, and 302, dealing with murder of Indian Penal Code. |
Stuart Pearce wanted me to play in the 'Team GB' football squad for the Olympics, but I said 'naaaaaaaaaaaaa mate - not likely'. |
For a start - he wasn't offering me any money. I earn £250,000 a week for Manchester United, and about the same from sponsorship with sporting clothes brands, Nike or summit, I can't really remember which one. Pearce said the Olympics is for amateurs. Sod that for a game of sardines!! |
And why would I interrupt my summer break to come and play for a team that haven't got a chance of winning anything? Bad enough I already play for two teams of losers - England (knocked out of Euro 2012 at the quarter-final stage) part-time and Manchester United (2nd in the premier league) full-time!! That's one hat-tr... |
Sunquick has recommenced its annual consumer promotion, Sunquick 'Drink & Win'. |
The mega promotion which commenced on January 21will continue till March 23. Those who take part stand a chance to win a double door Sisil refrigerator. |
To qualify for the competition, Sunquick customers must post the plastic seal on the lid of the Sunquick bottle with their name, address and telephone number to Sunquick 'Drink & Win' P.O. Box 161, Colombo. |
Sunquick propaganda units will visit over 160 towns including the Northern and Eastern provinces during the promotion. Customers can hand over their entries to the propaganda vehicles as well. |
The promotion was designed to recognise and reward Sunquick brand loyalists. |
Sunquick, a Danish brand is consumed by millions in over 120 countries. The Scan Products Division of C. W Mackie PLC is Sunquick's local distributor. |
Bend is getting bluer, while Democrats are narrowing the gap with Republicans in other populated parts of Deschutes County, precinct-level election results released last week by the county clerk’s office show. |
Voters in Bend elected three Democratic women to the City Council and boosted Democratic Congressional candidate Jamie McLeod-Skinner to a victory in Deschutes County. The Bend area, plus a sprawling precinct that contains much of the Deschutes National Forest, gave Democratic county commission candidates and state Hou... |
Although she didn’t win the election, McLeod-Skinner won big in Bend, capturing more than 55 percent of the vote in most of the city’s precincts. In Sisters and Sunriver, she held Greg Walden, R-Hood River, to a plurality of the vote. |
Victories for Democrats in Bend and improving performances in the rest of the county continue a trend Deschutes County Democratic Party Chairman Jason Burge said he’s seen since moving to Bend six years ago. Since, Democrats have added 10,000 more registered voters, and Republicans have added 5,000, he said. |
“Bend is very blue, and the county is turning purple,” Burge said. |
In the Bend area, Republicans won just one seat: Buehler will be succeeded in the 54th House District by fellow Republican Cheri Helt, a restaurateur and member of the Bend-La Pine School Board. Democrats have 6,000 more voters in the district than Republicans. Helt breezed to victory after her Democratic opponent lost... |
The Bend City Council is officially nonpartisan. Both political parties had a slate of candidates they supported. Sarah McCormick, a political newcomer who ran against incumbent City Councilor Barb Campbell and frequent candidate Ron “Rondo” Boozell, performed the best of the three Republican candidates. |
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