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Salmon and Trout Art
British Columbia Emerald Sea
Tropical Oceans Underwater Beauty
Landscapes in Colour
Landscapes in Black and White
Abstract and Reflections
Salmon Images
Salmon Resource Page
Fishing Images
Salmon Enhancement
Clipping Path Images
Pacific Rockfish
Cold Water Fish
Cold Water Reefs
Tropical Coral Reefs
Seastars
Marine Mammals and Reptiles
Scuba Divers
The Watershed
Water- Essence of Life
Campbell River Images
Large Format Images
Commercial Work and Licensing
Specialty and Private Shoots
Water Dogs
Water Model Photos
Water Portraits
Presentations and Events
Concierge Photography
Photo Reproduction Methods
Image making with a unique perspective
While growing up in New Zealand, Eiko acquired his first SLR camera at the age of fourteen. He quickly discovered his passion for capturing images of animals, especially birds, in their natural habitat. During extensive trips along the West Coast of British Columbia and Alaska in the early 1990’s, his focus shifted to coastal landscapes above and below the waterline.
The catalyst that drew Eiko deeper into underwater photography were two shark diving expeditions in 2011.
Whether exploring the ocean or alternate bodies of water, such as marshes and rivers, Eiko has developed a dramatic style in which he celebrates the corners of our world which are seldom seen. He captures the surreal through constant awareness of lighting and unique angles. He has won awards and has been published in numerous international magazines, including National Geographic, British Columbia Magazine, Diver, Sport Diver, Daily Mail, People! , Submerge, Ducks Unlimited, and Orion to name a few. His Fine Art Photography has also been sold around the world. While a big part of his work focuses on Salmon and local watershed issues, other underwater and topside subjects round out his collection. Eiko currently engaged in filmmaking with his partner through their production company Nourish Journey Productions. Eiko is a fellow of the Royal Canadian Geographic Society and is a proud member of the OCEAN ARTISTS SOCIETY.
Artists Statement-
At times I am overwhelmed by the beauty of the world around us. I am passionate about sharing this Pacific Northwest environment with everyone. Through artistic and dramatic imagery, I endeavor to offer people a glance of that world, whether they live in a big city condo, or have no ability to experience the world below or out in nature. My work is all about drawing attention to the entire environment and watersheds, from the mountaintops all the way down, and into our vast, but fragile oceans.
Because of my work with wild salmon, I see firsthand the importance of a healthy, sustainable environment. Vibrant, wild salmon runs are one of the first things to diminish as encroachment and pollution affect a river.
I believe the tide is turning for the benefit of our wilderness and our future generations. By people becoming aware of the need to protect our precious waterways, the salmon and associated wildlife are being helped. I look to the resilience of wild salmon as a great example of the forces of life itself. By making needed changes in our actions towards the environment, nature will achieve a balance and be restored to its once abundant state.
Watch the above video for my thoughts on Salmon Photography and how I feel it helps with awareness and conservation.
Follow Eiko Jones Photography on Facebook , Instagram and Twitter @eikojnz to keep up with the latest happenings.
Eiko is also producing two films about salmon at the moment.
Heartbeat of the River is an intimate look at the lives of the salmon of the Campbell and Quinsam Rivers. Salmon Capital Campbell River is a story of how salmon shapes the identity of Campbell River and led to its crowning as Salmon Capital of the World.
If you enjoyed viewing this post / page I would love it if you shared it with your world.
Salmon Photographs
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Reliance Jio Infocomm
Veon
Regulatory policy and implications
Next generation mobile services
Broadband build-out
Network operators' competitive challenges
Denmark telecommunications
TDC shareholders approve US$6.5bn takeover deal
April 10th 2018 | Denmark | Mobile | Multiple companies
On April 9th DK Telekommunikation ApS said that more than 90% of the shareholders of TDC AS had accepted its takeover proposal. DK Telekommunikation is backed by Danish pension funds—PFA, PKA, ATP—and Macquarie Infrastructure and Real Assets, an Australian investment company.
The board of TDC, Denmark's largest telecoms company, accepted the Dkr40.3bn (US$6.5bn) offer in February. A month later, the deal won clearance from the EU anti-trust regulator. The approval from over 90% shareholders will now allow the investor group to move ahead with its plan to de-list TDC's shares from the Copenhagen Stock Exchange.
Under the terms of the takeover deal, DK Telekommunikation plans to split TDC into three separately managed units, focusing on the networks business, the Danish retail business and the Norwegian operations. The move is expected to help it better comply with the Danish government's plan to provide at least 100Mbps of broadband download speed to all households by 2020.
Re-organisation of TDC will also open up its network infrastructure for use by other telecommunications companies, thereby creating a new revenue source for the company, as it gears up to invest in infrastructure upgrades. The former Danish monopolist held 37% of the country's mobile market at end-2016, ahead of rivals Telenor Co Ltd, Telia Co AB and Three.
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[X]Best of the East Bay 2017
Select a section Best Of Nominees Best of the East Bay 2017
Best of the East Bay 2017: Arts & Music
Best of the East Bay 2017: Cannabis
Best of the East Bay 2017: Shopping & Services
Best of the East Bay 2017: Entertainment & Nightlife
Best of the East Bay 2017: Readers' Poll Winners!
Best of the East Bay 2017: Food & Drink Writers' Picks
From CBD to extracts, its our writers' favs.
By Express staff and contributors
Photo by Lance Yamamoto
Corrie Abraham will help you learn how to grow your own at Berkeley Indoor Garden (page 87).
Best Place to Get Started Growing Indoors
Berkeley Indoor Garden
Cannabis has been growing outside for a long time — still does. Throw it in a pot, give it sun and plenty of water, and you’re on your way to some bona fide homegrown. But maybe the city you live in banned outdoor growing, maybe you have nowhere on your property that gets good sun, or maybe your neighbors are too nosy. If growing outside is out, growing indoors is a very viable alternative, and if you’ve never done it before, Berkeley Indoor Garden is the place to go. It’s been in business since 1984 and sells everything you’ll need to get started, all in one bundle or bagged individually. They got pots, soil, nutrients, tents, fans, carbon filters for smell, lights (no LED though), timers, pH testing kits, scissors, books, catalogs, and even all the fixings for a hydroponic grow. And, they’ll answer any question you could have. Corrie Abraham, the owner, said they used to cater to big-time growers, but now there are many inexperienced people coming in, and she loves educating the community. For those who don’t know, the first step is to decide where you’re putting the plants. The folks at Berkeley Indoor Garden will take it from there. 844 University Ave., Berkeley, BIGHydro.com. (Nate Sheidlower)
Illustration by Raisa Yavneh
Add CBD to your workout recovery.
Best Pot to Smoke After Making Gains
CBD OG by C.R.A.F.T.
I am perhaps more qualified than the average stoner. At one point in my career, for instance, I programmed and edited a weekly, 40-page pot publication. And I remember visiting dispensaries when Bush the II was president — when clubs operated on the DL. But who cares about my credentials? What you’re interested in is the lovely, classically structured nug that I’m about to praise: CBD OG, the award-winning indica flower from East Bay-based Citizens Research Alliance For Therapeutics, aka C.R.A.F.T. This flower is loaded with pain relief, in the form of CBD lab-tested at 19.2 percent. But the OG in the strain still offers a nice THC buzz, which belies the experience I’ve had with most CBD offerings. And, C.R.A.F.T.’s CBD OG is a beauty. It’s lightly dusted with trichomes, studded with Peruvian-brown hairs, and boasts a flavorful citrus-lemon aroma and taste, plus a gently dank character. This was some amazing bud that proffered a clear-headed high and exceptional relaxation. I would recommend this for anyone looking to recover after a hard workout, or if you want to relieve joint or muscle pain. Bonus: This strain is lab-tested and sustainably grown right here in The Town. BayAreaCRAFT.org. (Nick Miller)
Best Way to Get Weed With Minimal Human Interaction
Eaze
Getting high can be a fun and communal experience. Then again, after a stressful day of work, especially if you work directly with customers, being around people can be a complete buzzkill. Sometimes you just want your wares with minimal human interaction. Then there’s Eaze, which can get you a medical card — while you still need one — and pot from nearby dispensaries delivered to you; you don’t even have to leave your house. You can interview for your doctor’s recommendation right over your phone and have your wares delivered immediately after. (Yes, for now, humans do the delivery.) While brick-and-mortar pot shops are vitally important, sometimes going outside and waiting in line can be too big of a barrier for proper relaxation. You know, California problems. Eaze.com. (Brian Krans)
Best Thing to Do While Stoned and Feeling Bogged Down by Gentrification
“18 Dummy”
The East Bay is a big area and there’s no better way to experience that than on the bus. Yup, AC Transit, chariot of the gods. So skip Uber. My favorite line is No. 18, where you can find me every day contemplating the meaning of life. It used to span the diverse neighborhoods between Marin Avenue in Albany all the way to Montclair in Oakland, but now it turns into another line at Lake Merritt BART. If you’re new in town, make this your first order of business. Blaze while you wait for the bus. Put your guard down as you get on. The bus attracts people of all walks of life and, unlike BART, on the bus people actually talk to each other. The air is fresher, and nothing beats being above ground. Find a seat in the back where you can put your feet up. If you’re femme-identifying, take up hella space by man-spreading yourself, one leg by the window, the other hunched over the seats in front of you. Cue your favorite record, then look out the window and nowhere else ’til the last song ends. Take everything you see and think as the gift that it is. It’s a wonderful reminder of what it feels like to be alive and lucky enough to live in the East Bay. ACTransit.org. (Nic Feliciano)
Photo by Rosa Furneaux
Combine cannabis and yoga at Ganjasana at Ume in Oakland.
Best Place to Add a High to Your Down Dog
Ganjasana at Ume
It’s a stressful time, and these days reaching full relaxation may require more than just a typical yoga class or smoke session. Combine the two at Ume, where card-carrying cannabis consumers can quiet their minds before they align their bodies during the yoga studio’s Ganjasana class. The description boasts that the class enables participants to “feel subtle adjustments to take their practice to a new and deeper level,” but even if that’s not what you are going for, it’s going to be a good time. You need to bring your own pot, proof of a medical marijuana card (at least until next year), and be over 21, but all yoga levels are welcome. For an hour and a half, just listen to music, breath in and out, hold some postures, and prepare for a full-body and mind chill. Everything is going to be all right. 1051 Broadway, Oakland, UmeYoga.com. (Gabrielle Canon)
Best Wax to Cure Writer's Block
Inspired Extracts
There’s a joke that floats around the heads of journalists from time to time: “Write drunk, edit sober.” Now, that’s not always the best idea. But anyone who writes anything knows that the page always starts blank, and it’s often harder to write one sentence than to fill it. Sometimes, you need inspiration. Inspired Extracts wax is manufactured in the East Bay, with cannabis grown in the East Bay, and is sold at local dispensaries. It will provide that inspiration to kick-start your writing, without making you an alcoholic in the process. Local research from UC Berkeley has shown cannabis to stimulate creative drive and open your mind to new possibilities. Sativa strains are considered more stimulating, but everyone reacts to every strain differently. Inspired Private Reserve strains like Purple Disneyland and Starfruit O.G. are lab-tested with over 95 percent cannabinoids and taste great. This wax will live up to its indistinguishable logo of a beaming light bulb and fill your head with ideas. Of course, we as writers still need to reach deep within to form the sentences and craft the draft, but getting inspired to break that initial rut is as simple as getting Inspired. Instagram.com/InspiredExtracts. (NS)
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(Sorry, no information is currently available for other years in this same award category.)
Tags: Best of the East Bay 2017, Best of the East Bay 2017
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Help for Stutterers - New Interest After 'King's Speech'
After 'King's Speech,' New Interest in Help for Stutterers
VOA - Melinda Smith | Washington April 11, 2011
Photo: VOA
A young man at a University of Maryland speech clinic works with a therapist, April 2011
Many people who stutter cheered the recent attention given their condition when Hollywood bestowed four Academy Awards on The King's Speech, a movie about a real-life British king's struggle to overcome his severe stutter. Now new research is getting to the root causes of stuttering, and a group of young people are learning to cope with this speech disorder.
The year was 1926 and the Duchess of York was anxious to help her husband, the future King of England, overcome a severe speech impediment. She introduced him to a speech therapist named Lionel Logue.
The King's struggle to correct his stammer, or stutter, has resonated with many of the 68 million people worldwide who suffer from this neurological disorder. Listen to the feelings expressed by young patients at a University of Maryland speech therapy clinic."I was reading in class and they laughed at me," said Ruben Ntom, struggling to speak. "I felt so bad."
"It can really have a significant impact on your life," Michael Giannangeli said.
The young men in this group session include college students and one professor. They are intelligent and well-educated. Yet they admit they were nervous every time they had to introduce themselves or speak in public.
Stephen Ernst said he tries to ease the tension by letting his listeners know in advance he has a speech disorder.
"It definitely helps to take away that elephant in the room [the issue of stuttering] when you know that somebody knows that you stutter, and you know that you stutter but you just don't want to bring up that topic," he said.
Scientists at this recent Washington conference say that stuttering could be linked to the malfunction of certain brain cells associated with speech. Research also has shown that some stutterers process speech and language in a totally different part of the brain than those who speak normally.
Sixty percent of people who stutter have a family history of it. Stuttering also can be caused by developmental delays in early childhood, and it affects four times as many boys as girls.
While it is rare for adults to begin stuttering, it does affect some patients who have had strokes or traumatic brain injury.
Despite deepening scientific knowledge, Professor Nan Ratner of the University of Maryland said many people are still ignorant about the causes of stuttering. "Many people misunderstand and think stuttering is about emotional adjustment, your anxiety level, or something that scared you as a child."
The young men in this clinical session said they have gained self-confidence by sharing their experiences and are less intimidated when speaking to others.
Ben Goldstein spoke for all of them when he asked for a little patience from listeners. "Some people think it's helpful to cut in and finish it for us. We actually enjoy finishing our own sentences just like everybody else does."
If the real King George were alive today, he might just say ‘I agree.’
Article and Video from VOA
Labels: films, Health, movies
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Edmonton Oilers adidas Navy Alternate Authentic Jersey
EDMONTON OILERS 3RD JERSEY TODD MCFARLANE DESIGN KOHO OIL DROP SIZE LGE VGC!
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VINTAGE KOHO NHL EDMONTON OILERS #83 Hemsky JERSEY SIZE XL
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edmonton eskimos jersey,
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Home » Equality and human rights in practice » Providing Services » Case Study: Citizens Advice » Case Study: Age UK
Case Study: Age UK
Age UK’s Our Rights Our Voices programme worked with older people to develop their understanding of human rights and how they are relevant to their lives.
80 older people from eight older people’s forums across England were supported to put their rights into practice.
Example: The Carrick Over 50’s Forum used human rights to challenge the council’s decision to cut bus services in a rural area. This compromised older people’s ability to get to the hospital, shop, meet friends – and was potentially in breach of Article 8 of the Human Rights Act 1998.
The group persuaded the bus company and council to put on a bus and provide an important lifeline for older people in the rural community.
Part of the project was a toolkit (pdf) that set out which human rights are most commonly relevant to older people and why; and gave examples of how the eight forums used their human rights.
Papers and Tenders
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Nick Bruel presents Bad Kitty Joins the Team
Malaprop's Bookstore and Café
Address: 55 Haywood Street, Asheville, NC 28801
Email: info@malaprops.com
Join us to kick of the tour for Nick Bruel's newest book! This is one the kids will always remember!
See Kitty as you've never seen her before: EXERCISING (reluctantly) in the latest installment of the phenomenally successful New York Times–bestelling series. Kitty is terribly out of shape—she can barely torment Puppy without needing a break to huff and puff! When Kitty's owner catches her wheezing, Kitty is told it's time to EXERCISE. It takes some serious convincing, a high-stakes competition, and a little bit of trickery but eventually Kitty gets into the competitive spirit . . . albeit reluctantly. What did you expect? Will our favorite feline friend learn what it means to be a good sport? Find out in this hilarious addition to the Bad Kitty series.
Nick Bruel is the author and illustrator of the phenomenally successful Bad Kitty series, including the CBC Children's Choice Book Award winners Bad Kitty Meets the Baby and Bad Kitty for President.
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Study: Cancer “vaccine” injected directly into tumors works in mice
People with advanced cancers
Relevance: Medium-Low
Strength of Science: Medium-Low
Research Timeline: Animal Studies
Immunotherapy is treatment that uses the immune system to fight cancer. Still in its infancy, it is a promising therapy that is changing how certain cancers are treated. A new study reports that tumors in lab mice were eliminated when they were injected with two immune system-enhancing agents. This new approach is called in situ (at the original site) vaccination because the injections are given directly into the tumors. It worked on several different types of mouse tumors, including lymphomas and breast tumors. This approach may be safer than conventional immunotherapy because it uses very low doses of the agents and it does not require tumors to have particular markers. (02/23/18)
At a glance In-depth
Findings Limitations
Clinical trials Resources and reference
Studying the effectiveness of treating cancer by injecting immunotherapy agents directly into tumors.
For decades, researchers have attempted to harness the body’s natural immune system to eliminate cancer. In this study, researchers showed that injecting very small amounts of two immunotherapy substances into the tumors of lab mice triggered an immune system response that eliminated the targeted tumor and other cancers as well. Moreover, the treatment was quicker and less costly than other currently used types of immunotherapies, because there was no need to discover specific targets or customize treatment against them. And since the drug was only injected into the tumor rather than being given systemically (intravenously or orally), the mice experienced less side effects.
Directly applying two immune agents to tumors is a new approach that worked well in laboratory mice.
In mice with transplanted lymphoma tumors at two separate sites, injecting one tumor site with the two agents eliminated both the treated and untreated tumors.
87 of 90 mice were cured of lymphoma
Although the cancer recurred in three of the mice, their tumors regressed again after a second treatment.
Mice that were genetically engineered to develop breast cancers in all 10 of their mammary pads also responded to the treatment:
Treating the first mammary tumor to develop often prevented the occurrence of future tumors and significantly increased the rodents’ life spans.
To determine whether the immune cell response was specific to different cancers, researchers transplanted two types of tumors into the mice: lymphoma cancer cells in two locations and colon cancer cells in a third location.
When one lymphoma site was treated, both lymphoma tumors regressed, but the colon cancer cells remained unaffected.
These results suggest a very targeted approach: only tumors with the targeted protein—in this case lymphoma—at the treated site were affected. Treating the lymphoma did not affect the colon cancer.
While this study had excellent results—all of the subjects had substantial responses and lived longer—it is important to remember that this research was done in mice, and lab studies in animals don't always translate to the same results in people. However, both of the agents used in this study are also being tested in humans. One of the agents is already approved for use in humans and is currently being tested in patients as a single agent and in combination with other therapies. The other agent is being studied in early clinical trials. In January, the researchers of this study began a small trial in 15 patients with low-grade lymphoma.
If successful, researchers believe this type of immunotherapy treatment could be useful for many tumor types. In the future, patients may receive immunotherapy injections prior to surgical removal of their cancer as a way to prevent recurrence or the development of future tumors that develop from genetic mutations like BRCA1/2.
Is immunotherapy an option for me at this time?
Are there any harmful side effects from vaccines, or from immunotherapy in general?
Do I qualify for any immunotherapy clinical trials?
NCT03789097: Vaccination With Flt3L, Radiation, and Poly-ICLC. This is a combination of 4 therapies, three of which are used to treat a single "target site" of your cancer (such as a lymph node or a single tumor), and the 4th is given directly into the blood stream (intravenous or "IV").
NCT02643303: A Phase 1/2 Study of In Situ Vaccination With Tremelimumab and IV Durvalumab Plus PolyICLC in Subjects With Advanced, Measurable, Biopsy-accessible Cancers. This is an open-label, multicenter Phase 1/2 study of the CTLA-4 antibody, tremelimumab, and the PD-L1 antibody, durvalumab (MEDI4736), in combination with the tumor microenvironment (TME) modulator polyICLC, a TLR3 agonist, in people with advanced, measurable, biopsy-accessible cancers.
NCT03831295: SD-101 and BMS-986178 in Treating Patients With Advanced or Metastatic Solid Malignancies. This trial studies the effects of injection of SD-101 and BMS-986178 into tumors for treating patients with metastatic cancers.
Who Covered This Study?
Cancer 'vaccine' rids body of multiple cancer types -- in mice
Injection helps the immune system obliterate tumors, at least in mice
One injection could kill cancer
Fox News Chicago
Vaccine giving new hope in fight against cancer
New cancer treatment? Vaccine kills tumors in mice—and human tests are starting soon
WorldHealth.Net
So-called "cancer vaccine" isn't a vaccine at all; it's actually immunotherapy that boosts the body's own immune function
Media Rating Details
Cancer immunotherapy is a treatment approach that uses the immune system to fight cancer. Some immunotherapies increase immune system activity throughout a patient’s body, while others target naturally occurring checkpoints that limit the anti-cancer activity of immune cells. Still others involve removal of a patient’s immune cells, genetically engineering them to attack tumor cells and then reintroducing them back into the body. Many of these immunotherapy approaches have been successful, but they also have significant downsides, from debilitating side effects to high cost and long preparation or treatment times.
If a mouse immune system could be stimulated to attack cancer cells by injecting a “vaccine” directly into a tumor.
Ronald Levy, MD, who holds the Robert K. and Helen K. Summy Professorship in the School of Medicine at Stanford University is the senior author of the study “Eradication of spontaneous malignancy by local immunotherapy,” which was published in the January 31, 2018 issue of Science Translational Medicine.
Levy and his team call this new treatment “in situ vaccination” because injecting minute amounts of two immunotherapy agents directly into a tumor triggers an enhanced T cell (a type of immune cell) response. One of the agents used is called a “CpG oligonucleotide,” a short DNA molecule that increases the expression of the OX40 receptor on the surface of nearby T cells. The other agent is an antibody that binds to OX40 receptors and activates T cells to attack tumor cells. The body “prescreens” these activated T cells to recognize only the unique cancer-specific proteins in the tumor. Some of these tumor-specific T cells move beyond the original tumor to find and destroy other identical tumors in the body.
Population(s) looked at in the study:
Mice that were implanted with identical lymphoma tumors in two sites.
Mice that were genetically engineered to develop breast cancers in all 10 of their mammary fat pads.
Mice that were implanted with identical lymphoma tumors in two sites and a colon cancer in a third location.
After in situ vaccination (injection of CpG and OX40) into one of two lymphoma tumors in 90 mice:
87 mice (97%) were cured of lymphoma.
Although the cancer recurred in three of the mice, the tumors regressed again after a second treatment.
Other mice used in this study were genetically engineered to develop estrogen receptor-negative and progesterone receptor-negative tumors in all 10 of their mammary fat pads.
In situ vaccination (injection of CpG and OX40) into the first developing mammary tumor:
Prevented tumors from developing in other fat pads.
Significantly increased the animal’s life span.
In some cases, a second tumor was present at the beginning of the vaccination and treatment of a single tumor led to significant reduction in growth of the contralateral tumor.
Finally, the researchers explored specifically how this immune cell response affected different cancers. In mice with implanted lymphoma tumors at two different sites and one colon cancer tumor:
After in situ vaccination (injection of CpG and OX40) into one of the lymphoma tumors:
Both the injected and the non-injected lymphoma tumors regressed
the colon tumor continued to grow.
In a related experiment, mice that were implanted with two colon cancers and one lymphoma tumor were given an in situ vaccination (injection of CpG and OX40) into one colon cancer tumor:
Both the injected and non-injected colon cancer tumors regressed
the lymphoma tumor continued to grow.
This study’s results are excellent and exciting: all of the mice that were treated had substantial tumor responses and lived longer. However, it is important to remember that many cancer therapies that work well in rodents don’t translate to humans. It should also be noted that this approach will only work in tumors that have been infiltrated by the immune system.
A new, small trial of situ vaccination with CpG and OX40 for low-grade lymphoma will soon begin enrolling patients; it will be a starting point to understand whether this approach can be as successful in people as it was in these study mice. Even if the human trial is successful, it will still be years before this type of tumor “vaccination” can be broadly offered to patients.
Dr. Levy states, “Our [new] approach uses a one-time application of very small amounts of two agents to stimulate the immune cells only within the tumor itself. In the mice, we saw amazing, bodywide effects, including the elimination of tumors all over the animal.” However, he also cautions that if this approach proves successful in humans, it would likely be only one of a number of tools used to fight the cancer. While exciting, a lot of unknowns about this treatment remain: Will it work on everyone? How many cancers might be impacted? Does it have the potential to overstimulate the immune system? Further research will be needed to answer these and other important questions.
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FORCE Information: Immunotherapy
FORCE Research Study Search Tool: Search for Breast Cancer Treatment Studies
FORCE Webinar: HBOC Research Study Search Tool
FORCE Blog: Why I Chose Immunotherapy for Pancreatic Cancer
Clinicaltrials.gov: A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley)
Sagiv-Barfi I, Czerwinski DK, Levy S1, Alam IS, Mayer AT, Gambhir SS, Levy R. "Eradication of spontaneous malignancy by local immunotherapy." Sci Transl Med. 2018. 10(426).
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INSTITUTE INDEX: The shifting private-prison landscape in Southern states
By Sue Sturgis
August 9, 2018 - With private prisons under scrutiny, some Southern states have moved away from contracting with them — but some have gone in the other direction. Where does your state stand?
VOICES: Workers' unlikely victory over outsourcing in Tennessee
By Elizabeth Stanfield Jon Shefner
February 6, 2018 - In the harshest of environments for union organizers, United Campus Workers achieved a historic win in the fight against Gov. Bill Haslam's privatization scheme.
With private immigrant detention up for review, a former inmate describes the harsh life on the inside
By Rebekah Barber
September 2, 2016 - The same day a high-profile undocumented student who was recently released on bond from a private detention center in Georgia detailed his experience at a press conference, the Department of Homeland Security announced it would review whether to follow the lead of the Justice Department and cut ties with private prison contractors.
VOICES: Under Republican 'grass-eater rule' in Mississippi
By Joe Atkins
May 18, 2015 - The Republicans running Mississippi have the prison system in shambles, workers' compensation gutted, education on a precipice — and journalist Joe Atkins looking back to populist Louisiana Gov. "Uncle" Earl Long for solace.
Charter school power broker turns public education into private profits
By ProPublica
October 15, 2014 - Baker Mitchell is a politically connected North Carolina businessman who celebrates the power of the free market. Every year, millions of public education dollars flow through Mitchell's chain of four nonprofit charter schools to for-profit companies he controls.
Unions rail against Obama proposal to privatize New Deal success story
By Common Dreams
March 12, 2014 - The Obama administration continues its push to privatize the Tennessee Valley Authority, which provides electricity for 9 million people in seven Southeastern states without taxpayer subsidy and at prices below the national average.
Art Pope think tank behind campaign to discredit and defund Medicaid
December 17, 2013 - The Civitas Institute, a conservative think tank founded and bankrolled by N.C. budget director Art Pope, sought funding to portray the Medicaid program as "failed" and to urge funding cuts, according to leaked documents obtained by The Guardian. The effort comes as the McCrory administration wants to privatize management of the public health insurance program for the poor and disabled.
Private prisons lock in profits with lockup quotas
By Brentin Mock
September 20, 2013 - As U.S. incarceration rates fall, private prison companies are taking steps to guarantee profits with contracts requiring states to either meet prison occupancy quotas or pay for empty beds. Louisiana and Virginia are among the states locked into the highest occupancy guarantee requirements.
The strange politics of TVA privatization
April 16, 2013 - President Obama's latest budget proposes privatizing the Tennessee Valley Authority, which has been criticized as a socialist enterprise, yet Southern Republicans are opposing the plan. What's going on here?
VOICES: The danger of McCrory's Bobby Jindal imitation
By NC Policy Watch
April 10, 2013 - N.C. Gov. Pat McCrory wants to privatize the Department of Commerce and the state's Medicaid program, but the experiences of other states like Louisiana that have carried out similar plans point to serious problems.
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How the House is Becoming Less and Less Accountable to Voters
Nathan Nicholson
While we're on the subject of seats and votes in the U.S. Congress, let's look a little more closely at the increasing divergence between the national House vote and the makeup of the chamber.
Yesterday we discussed the limitations of using raw vote shares--that is, a comparison of the total votes cast for each parties' candidates across all districts--to measure national partisan sentiment. FairVote's Monopoly Politics House elections model attempts to capture that national sentiment more accurately. The model's "national two-party preference" metric measures the degree to which Democratic and Republican incumbents outperformed their respective districts' underlying partisan lean, which in turn is measured by how that district voted for president relative to the nationwide split in the presidential vote. By ignoring open seats and uncontested races and comparing vote margins to a uniformly defined baseline rather than summing raw votes, national two-party preference reduces the impact of the turnout disparities that make raw vote share a flawed measure. (See a fuller unpacking of this metric here.) Here's how national two-party preference has stacked up actual House results since 1996:
Sources: FEC, Cook Political Report, Monopoly Politics 2016
The projected values for 2016, drawn from our Monopoly Politics 2016 projections model, assume an evenly split national two-party preference of 50%. (The model allows users to simulate different House outcomes based on different values for national two-party preference in 2016, as well as different values for generic incumbency advantage--check it out.) A 50% split in 2016 isn't necessarily likely, but it serves to show the way the House is now stacked against the Democratic Party regardless of the national mood: if 2016 were a 50% year, Democrats would take just 191 House seats, or under 44% of the chamber. And it would take a national two-party preference of about 55.8% in 2016 to tip Democrats into a slim House majority--a much bigger wave even than the 2008 Democratic landslide, in which they were preferred by 54%.
The underlying cause of this imbalance is the interaction between demographic sorting and single-winner districts. Democrats, increasingly clustered in urban areas, are naturally "packed" into their districts, meaning their candidates tend to win by larger margins than Republicans: the average Democratic winner in 2014 won his or her race by a two-party margin of 44.1 percentage points, while the average Republican winner won by 39.7 points. But because each district elects just one winner no matter the margin, Democrats' more emphatic victories are meaningless with respect to the makeup of the House. Republicans' leaner margins are more efficient at winning more seats with fewer overall votes. (While intentional gerrymandering is also a factor here, natural patterns of partisan demography are surprisingly powerful on their own.)
This trend was masked for a while by the looseness of the parties' ideologies and more frequent ticket-splitting, with Democratic incumbents able to hold on to seats in relatively conservative districts, especially in the South. But the 2010 election exposed the underlying asymmetry by eliminating nearly all Democrats representing Republican territory--and now, with Republicans enjoying the advantages of incumbency in those seats and ticket-splitting becoming steadily rarer, Democrats are unlikely to claw those seats back in the foreseeable future. Partisanship is now such an effective predictor of House votes that our Monopoly Politics 2016 model confidently projected over 85% of 2016 House races less than a week after the 2014 midterms, using only recent election results as predictors.
The structural bias in the House currently favors Republicans, but this tilt in the playing field is problematic no matter its direction. With the parties increasingly voting as tight units rather than loose coalitions that cut across ideologies, democratic accountability depends on voters' ability to empower or reject the parties as legislative agenda-setters. When even a solid majority of the country can't hope to "throw the bums out" and push control of the House to the other party, the House loses its electoral tether to popular opinion--an alarming reality in the chamber designed to represent the American people. The structural bias in the House is a strong argument in favor of eliminating single-winner districts and instituting multi-member districts with fair representation voting, which would promote meaningful competition in almost every district and ensure the House much more faithfully reflected the will of the nation's voters.
Monopoly politics Fair representation Quick news
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Introducing the next great American pastime: beer pong. (1/14/09)
11yRick Reilly
Life of Reilly
Rick ReillyColumnist, ESPN.com
11-time National Sportswriter of the Year
Author of "Tiger Meet My Sister ... And Other Things I Probably Shouldn't Have Said."
2014 Inductee: National Sportswriters and Sportscasters Hall of Fame
There is only one place I know that combines tiny balls, plastic cups and vats of beer. Besides Jose Canseco's house, that is.
It's a beer pong tournament. This is a sport that requires a steady hand, faulty hearing and a titanium liver. It's believed that 73% of all tuition money goes toward it.
Beer pong is played on a table slightly smaller than Ping-Pong's, by teams of two. Ten cups, filled about one-third with beer, are set like bowling pins at the ends. As you try to toss or bounce a Ping-Pong ball into the cups on the side opposite yours, opponents jump and yell unspeakables about your mother. If you make it, they must drink it. First team to sink all 10 cups wins. It's very sophisticated.
But the beer pong I play is nothing like the kind in the World Series of Beer Pong, which I covered recently at the Flamingo Hotel & Casino in Las Vegas. That's where North America's 414 best pong teams competed for the $50,000 first prize. Second prize: bubkes. Gulp.
You have never seen such large people throw such tiny objects into such small receptacles with such hair-raising frequency. The best teams hit about 70% of their shots on the eight-foot tables. That's like pitching a quarter into a parking meter slot seven times out of 10.
More shocking was that it was more about pong than booze. Four of the 10 cups were filled with water, which worked out to one beer per player per hour. Regular pongers pour more than that on their Raisin Bran.
In fact, drinking was optional. One team used only water in the first round—Mrs. and Mrs. Lara and Kristin Mendez of New York City. That's right, two married women. Beer Pong: changing the world.
Still, there were quality team names, such as: He Sucks … I'm Good; Beer Pong … Because Jesus Would; and Chase's Mom ATM. There was also Francois the Butt Dusters, made up of my sons, Jake (21) and Kel (23). The Dusters started off 4–0, including a W over a team from Rochester, whose members, no joke, would, out of nowhere, slap each other hard on the face. The slapee, red-cheeked, would look at his partner—stunned—and then yell, "Yeeeeahhh!!!" One guy from Jersey ripped his shirt off just before a crucial point. One team played sitting on each other's shoulders.
The real drama centered on Albany's the Iron Wizard Coalition. These guys made last year's finals and sank their final cup while their opponents, Chauffeuring the Fat Kid, still needed four. They went triple Gramatica, jumping and dancing and hugging. "I had that money spent," says Mike Hulse, 28, of the Wizards.
But they forgot about beer pong's diabolical redemption rule, which allows a last chance as long as you don't miss another cup. Fat Kid never did. Four straight sinks. Pong history. Kid wound up winning the game and the cash. "Do I think about it?" says Hulse, who doesn't make much working for a cable company. "I think about it every time I look at a bill. Every freakin' time."
Alas, the Wizards wound up 49th this year. The Butt Dusters finished a valiant 182nd. The finals came down to the tourney faves: Smashing Time (Ron Hamilton and Michael "Pops" Popielarski, both 25) vs. Getcha Popcorn Ready (Brian Nentwig and Joe Radesco, both 23). The 6'4", 280-pound Hamilton chugged a bottle of Jack Daniel's beforehand. "The key today," he said later, "was me getting real drunk." (Maybe it wasn't always more about pong than booze.)
Popcorn, winner of the loser's bracket, needed to win both games to be crowned King Pong. Smashing Time had to win only one. Popcorn won Game 1. The next would be for everything. And that's when I saw something I've never seen in sports.
The two teams had made a secret deal before the match: If Popcorn won Game 1 and the tourney continued, the winners would give the losers $3,000. Can you imagine? "Tell you what," Kobe says to KG before Game 7. "Winner buys the loser a Rolls. Deal?"
Bad move for Smashing Time, which then proceeded to sink little white balls just like in Tiger's dreams. They used only 12 shots to make their final 10 and win easily. Twelve balls, 10 cups. Try that at home.
It should be noted that the final was filled with honor. Nobody mentioned anybody's sister or flashed unwelcome appendages. That's good. All this bush league stuff will have to go if we're going to take beer pong to the next level: the Olympics.
Hope they don't test for whiskey.
Love the column, hate the column, got a better idea? Go here.
Want more Life of Reilly? Then check out the archive.
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Ferries Cherbourg Dublin
< Irish Ferries
Cherbourg ▷ Dublin
Foot passengers Car (Es. Fiat 1100 D) Motorcycle MotorhomeSUV/JeepMore than a carMore than a motorcycleMore bicletedCars - RoulotteCar - TrailerMinibus Vehicle configurator (cars, campers, trailers, etc.)
Next departures to Cherbourg - Dublin
Irish Ferries
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Next departures to Dublin - Cherbourg
Address of the port of Cherbourg
Cherbourg (in Norman Tchidbouo) is a locality and a French municipality deleted of 27.121 inhabitants located in the department of the Manche in the Normandy region.
From February 28th 2000 it merged with the town of Octeville creating the municipality of Cherbourg-Octeville.
How to reach the port of Dublin
DART North from Dublin City Centre (Tara Street stations, Connolly or Pearse). The round trip ticket costs around 5 euro.
Bus number 31 or 31B from Eden Quay. The number 31 pass from the village before reaching Howth Summit, while the number 31B reaches Howth Summit directly from Sutton without crossing Howth (the stop for the Summit is near the Summit Inn pub).
Dublin information
Dublin, capital of the Republic of Ireland, is located on the east coast of Ireland, at the mouth of the River Liffey. Its most important historic buildings are the 13th-century Dublin Castle and the impressive St. Patrick's Cathedral, founded in 1191. The city's parks include the landscaped St. Stephens Green and the enormous Phoenix Park. inside of which the Dublin Zoo is located. The National Museum of Ireland documents the Irish cultural heritage.
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Female Lawyers Face Widespread Gender Bias, According To New Study
Kim Elsesser Senior Contributor
I cover the intersection of business, psychology and gender.
Female lawyers still suffer significant gender bias at work according to a new study. (Photo:... [+] Getty/Royalty Free).
It's not just less pay and fewer promotions. According to a recent survey of 2,827 lawyers, female lawyers, and especially women of color, are more likely than their male counterparts to be interrupted, to be mistaken for non-lawyers, to do more office housework, and to have less access to prime job assignments. The research was recently completed by the American Bar Association’s Commission on Women in the Profession and the Minority Corporate Counsel Association. Here are some of the depressing results of the study along with suggestions provided by the study’s authors on how to get the bias out of your organization.
Female Lawyers Mistaken For Janitors, Administrators Or Court Personnel
Female lawyers of color were eight times more likely than white men to report that they had been mistaken for custodial staff, administrative staff, or court personnel, with 57% reporting mistaken identity. Over 50% of white women had also experienced this type of bias, while only 7% of white male lawyers were mistaken for non-lawyers. One female lawyer reported, “I have frequently been assumed to be a court reporter. In my own firm, I’ve been asked if I am a legal administrative assistant on multiple occasions, even after making partner.”
Female Lawyers Relegated To Do Office Housework
Not only are female lawyers mistaken for non-lawyers, but female lawyers end up stuck with more of the non-legal office housework. Office housework is made up of tasks like scheduling meetings, planning parties, and doing actual housework like cleaning up the food after a meeting. And the present study finds female lawyers are far more likely than their male counterparts to bear the brunt of this office housework.
Why do women do more of the office housework? Women are expected to be helpful and therefore tend to feel social pressure to volunteer for these tasks. Organizations are also more likely to assign women to these tasks, because women are more likely to agree to perform them.
Female Lawyers Penalized For Assertive Behavior Required By The Job
Although assertiveness and self-promotion are often needed to succeed in the legal field, women often feel that they must walk a tightrope. If they are too assertive, then they are criticized for not behaving in a ladylike fashion. If they are not assertive enough, then they are often seen as lacking the confidence needed to succeed. Study participants confirmed their experience balancing on this tightrope.
“In the past year, I’ve been called ‘overconfident’ and ‘not deferential enough’ by co-counsel, another Asian American female. It was extremely frustrating as I was finally starting to feel confident and assertive and direct—acting as any normal white male attorney in a law firm would. I was subsequently removed from that case,” described on study participant.
Another attorney in the study describes her performance reviews, “my only feedback is ‘you need to find your more feminine or softer side. You need to act more like a woman.’”
Female Lawyers More Likely To Be Interrupted
Female Supreme Court justices are more likely to be interrupted, with 65.9% of all interruptions on the court directed at the three female justices on the bench (Ruth Bader Ginsburg, Sonia Sotomayor, and Elena Kagan). The same apparently applies to lawyers questioned in the present study with almost half of the female lawyers surveyed being interrupted in meetings, compared to only about a third of men. “White men don’t realize how much ‘space’ belongs to them or that they unconsciously feel that they own space. They frequently interrupt others, but if a woman on a conference call states her thoughts, she’s immediately criticized as interrupting,” described one female lawyer in the study.
Female Lawyers Paid Less Than Equally Qualified Colleagues
In one of the biggest findings of the study, women were much more likely than men to feel that they were not paid comparably to colleagues with similar qualifications and experience. Women of color described more pay inequity than white women, but both were far less likely than men to believe they were paid fairly. One female lawyer summed up, “One man was recently given a promotion because HR discovered he was being paid a lot more than me, with the same job title. So instead of increasing my pay, they promoted him to a higher title! Women can’t win in this environment.”
Female lawyers aren’t just perceiving that they are underpaid, they actually are underpaid. A national survey of law firm partners found that male partners earned a whopping 44% more than female partners.
Female Lawyers Penalized For Motherhood
Few men complain that they are not taken seriously at work after they become fathers, and research indicates that men often receive a fatherhood boost in their pay when they have a family. However, the female lawyers in this study often felt they were treated differently at work once they had children. Here’s how some female lawyers described it to the researchers:
“I was passed over for partner because I had a child. The two male attorneys who were hired at the exact same time as me, who had comparable prior experience, and same job responsibilities were made partner but I was not. When I asked why, I was told it was because I had given birth to a child.”
“The reality is that after you have children, you are treated differently and given less access to good cases, and therefore have less access to promotion.”
Eradicating The Bias At Work
As if it’s not bad enough to get paid less, have clean-up duty, and suffer frequent interruptions, female lawyers in this study also reported that they have fewer networking opportunities and less access to prime assignments then their male counterparts. And about a quarter of the female lawyers surveyed report that they have been sexually harassed at work. Although the bias seems to run through almost all aspects of work life for these lawyers, the study authors provide plenty of strategies to help eliminate bias in the law profession. The following five suggestions for eliminating bias at work were particularly compelling:
1. Use metrics. Keep track to determine if there are pay differences, difference in performance ratings, or difference in types of assignments given to different groups. In particular, organizations should examine if these metrics differ by gender, race or parents returning from leave. If your metrics reveal inequities in a particular department, help that department think through why there may be bias in their treatment of employees.
2. List hiring qualifications. In order to eliminate bias in hiring, organizations should write down exactly what qualifications are expected for a particular job. If qualifications are waived for a specific candidate, require an explanation of why they were waived—and keep track to see for whom requirements are waived to determine if there is any bias.
3. Define culture fit. Too often employees think culture fit is hiring people like themselves, or people they’d want to share a beer with after work. The problem is, this criteria often results in hiring bias. To eliminate this bias, the authors suggest defining what culture fit in your organization means, prior to the hiring process. As an example, Google defines their culture fit this way: “Googleyness: …enjoying fun, a certain dose of intellectual humility . . . a strong measure of conscientiousness . . .comfort with ambiguity . . . and evidence that you’d take come courageous or interesting paths in your life.”
4. Institute housework interrupters. To minimize women bearing the brunt of office housework, don’t ask for volunteers for these tasks. Instead, develop a rotation or ask administrative staff to help with these tasks.
5. Start mentoring programs. Establish a mentoring program to help all employees network and have access to guidance from more senior employees.
Follow me on Twitter or LinkedIn. Check out my website.
Kim Elsesser
Inspired by my prior career developing quantitative trading strategies for Morgan Stanley, I’m now trying to solve women’s issues at work—including the wage gap and sex
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Apple To Public Transit Riders: Take A Hike
Tomio Geron Former Contributor
What you'll see if you click 'public transit' in the iOS Maps app
Apple just released its new highly anticipated iPhone operating system iOS 6 to the public.
The upgrade offers tons of new features. But the biggest change for me so far is the new Apple Maps app, which replaces the Google Maps app. Now, the Google app wasn't perfect. I did not like how the blue line of your trip route covered the traffic color (red, yellow or green) so that you couldn't tell what the traffic was on the way.
But the new Apple Maps app is terrible - particularly anyone who uses public transit, as I do and many who live in big cities. The postive of the app is that Apple has added turn-by-turn navigation, which was missing before in the Google app. And the directions for driving look great, especially with the new directions that look like street signs and are much easier to read than Google's directions.
But the new Apple Maps app does not have transit directions included in the app. The only directions it gives are driving and walking directions. If you click on the transit option for directions, Apple clicks you off to options for other downloading other apps to find transit directions. For people who use public transit as their daily way to get around town, this doesn't help at all. Since maps are one of the most used apps on the smart phone, this is a major loss. Of course you can go and download another transit app. But that's not the point. Apple is downgrading transit as a method of transportation.
So what Apple is saying is that if you're an iPhone user, you better be a driver or a walker. As for public transit, not that important. Maybe Apple employees all drive to Cupertino for work? Or they catch a free company shuttle from San Francisco? Well, maybe it will be in the next update. Not very environmentally friendly for a company that prides itself on the clean-tech aspects of its manufacturing process.
Tomio Geron
I was previously a staff reporter at Forbes covering start-ups and venture capital. I was previously a reporter for Dow Jones VentureWire where my work also appeared in ...
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31-35 Park Row, Nottingham, Midlands, NG1 Serviced offices from £450
The building comprises three adjoining, self-contained office buildings constructed in the late 1980s. Once the refurbishment of one of the buildings to new office space is complete, there will be suites from 150-2200 sq ft. The centre has on site parking and will offer reception services.
Nottingham is the main commercial hub of the East Midlands with a broad-based economy, two universities and an urban area population of 915,000 (2015). The building is located on the edge of the city centre to the west of the main retail area, in the traditional office core with good access by road and public transport. Junctions 24-26 of the M1 are within 5 to 11 miles and Nottingham train station is located approximately 0.6 miles away providing access to rail services across the UK including London St Pancras (1hr 45 mins). Extensive retail, restaurant and leisure amenities are accessible within walking distance in Nottingham city centre.
8 mins drive
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Netherfield (4.3 mi)
31-35 Park Row, Nottingham...
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Pricing from £1000
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Nottingham0.29 mi
The Park, Nottingham0.45 mi
Nottingham, UK0.61 mi
Lenton, Nottingham1.0 mi
Forest Fields, Nottingham1.12 mi
Queens Drive Industrial Estate, Nottingham1.2 mi
Thorneywood, Nottingham1.31 mi
New Basford, Nottingham1.39 mi
Bulwell, Nottingham1.64 mi
Lenton Lane Industrial Estate, Nottingham1.66 mi
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EU backs tariffs against US as trade war escalates
EURACTIV.com with AFP
Trade Commissioner Cecilia Malmström [European Commission]
EU countries approved a raft of tariffs on Thursday (14 June) targeting US goods including whiskey and motorcycles in retaliation against painful duties imposed by President Donald Trump on European metals.
Europe’s move fuels a growing transatlantic trade war just days after a disastrous G7 summit in Canada at which Trump lambasted his allies on the issue and refused to adopt a joint statement.
US-Canada dispute escalates after tense G7, Europeans criticise Trump
The United States and Canada swung sharply on Sunday (10 June) toward a diplomatic and trade crisis as top White House advisers lashed out at Canadian Prime Minister Justin Trudeau a day after US President Trump called him “very dishonest and weak.”
The European countermeasures aimed at €2.8 billion ($3.3 billion) of American imports come after Trump on 1 June followed through on his threat to impose tariffs on European steel and aluminium exports.
“Member states have today unanimously supported the commission’s plan for the adoption of rebalancing measures on the US tariffs on steel and aluminium,” a European Commission source told AFP on condition of anonymity.
The source added that the EU tariffs would take effect “in coming days”, with other officials saying they would be implemented by the beginning of July.
Brussels first drew up the list in March when Trump initially floated the 25% tariffs on steel imports and 10% on aluminium, which also target Canada, Mexico and other close allies.
Trump starts trade war with allies, Europe to respond 'within hours'
President Donald Trump announced on Thursday (31 May) that the United States would slap tariffs on steel and aluminium from the EU, Canada and Mexico, prompting Europe to say it would respond with “counterbalancing measures within hours” in what amounts to a trade war with Washington.
From blue jeans to motorbikes and whiskey, the EU’s hit-list of products targeted for tariffs with the US reads like a catalogue of emblematic American exports.
The list does not specifically name brands but European Commission chief Jean-Claude Juncker spelled out in March that the bloc was “preparing import duties for US products including Harley-Davidson, bourbon and Levi’s jeans.”
‘Breeches of cotton denim’
The EU imported some €415 million worth from the US in 2017, along with another €150 million worth of whiskey without the “bourbon” designation.
Cranberries, cranberry juice, orange juice, sweetcorn and peanut butter are among the other food products targeted.
The list hits clothing including “trousers and breeches of cotton denim” along with bed linen and men’s leather footwear, eye make-up and lipsticks, plus a host of steel products.
“The EU will exercise its rights on US products valued at up to €2.8 billion of trade, as notified to the WTO (World Trade Organization),” the commission source added.
Transatlantic ties are at their lowest level for many years due to rows over a host of issues including the tariffs, the Paris climate agreement, the Iran nuclear deal and the new US embassy in Jerusalem.
But relations plumbed new depths at the weekend as Trump abruptly rejected the text of a G7 statement and bitterly insulted his Canadian host, Prime Minister Justin Trudeau.
Trump claimed America had been obliged to levy the metals tariffs as it has been exploited as the world’s “piggy bank” under existing arrangements.
His counterparts however said they were equally determined to protect “rules-based” international trade.
Trump’s outbursts were the latest in which he has clashed with America’s closest allies, even as he has had warm words for autocrats like North Korean leader Kim Jong un, with whom he had a historic meeting on Tuesday, and Russia’s Vladimir Putin.
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News Release 23-Oct-2019
Young universities in Asia are strongly represented in rankings for high-quality research output
New Nature Index rankings of universities aged 50 and under reveal that institutes in Asian countries are performing particularly well in terms of output of high-quality research
The first Nature Index Young universities tables and supplement, which rank universities aged 50 and under have just been published. The tables reveal that young universities in China, South Korea and Singapore are performing particularly well in terms of producing high-quality research. Two tables are included in the print version of the Young universities supplement: a top 50 table that ranks young universities by their Fractional Count (FC*), and a top 25 rising table that ranks young universities according to the difference in their FC from 2015 to 2018. The online tables also include rankings broken down by subject.
Further features in the supplement explore the reasons why young universities are so successful at producing high-quality research. One interesting finding from the supplement shows, for example, that Germany and China each have 11 young universities in the top 100 Nature Index of young universities, yet the collective output of Germany's young universities is less than one-third of their Chinese peers. Case studies of successful young universities from Switzerland, China, South Korea, the US, Australia and France are presented, as well as an interview with the president of Nanyang Technological University in Singapore.
David Swinbanks, Founder of the Nature Index, said: "It is interesting to observe that many of the most successful young universities have similar traits. Apart from being free from the traditions that often characterize older institutions, these younger universities often have strong interdisciplinary cultures, and pride themselves on promoting creative thinking, as well as providing leadership opportunities for young and mid-career researchers. These measures also help to attract a diverse student population and encourage the pursuit of unconventional research that inspires innovation."
The tables and supplement are available here.
Elizabeth Hawkins
elizabeth.hawkins@springernature.com
49-622-148-78130
@SpringerNature
http://www.springer.com
GRADUATE/POSTGRADUATE EDUCATION
GROUP ORGANIZATION
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Listen with your eyes
About EuroArts
Our Production Department
DVD Newsletter
TV/License
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TV / License catalogue
This catalogue represents around 1800 TV highlights of performance and documentary programming in a wide variety of genres, including opera, ballet & dance, orchestral music, jazz and entertainment.
Ballet / Dance
Choral Music / Vocal
More than 90 min
Prog. No.
Sounds of the Sea
This programme is based upon the folk music of the South coast fishermen and their reminiscences.
ESP 2 is the true legacy of the music of Miles Davis, kept alive by his former sidemen who are now bandleaders in their own right. Together they honor the heritage of the legendary trumpet master.
Rabih Abou-Khalil "Perfume Project"
The form, rhythm and tone of Rabih Abou-Khalil's music usually follow the pattern of Arabian instrumental music, but for his amazingly cosmopolitan sound Abou-Khalil has created a synthesis of Arabian music with Western classical and jazz idioms.
Rypdal - Vitous - Gurtu
The two musicians Terje Rypdal and Miroslav Vitous recently found a kindred spirit in the Indian percussionist Trilok Gurtu, who manages to play drums and percussion simultaneously on the drum set he designed himself.
After decades of work with the Rail Band of Mali, Salif Keita launched the album "Soro" in 1982, which marked another breakthrough for African music world-wide, becoming one of world music's biggest selling albums ever. This programme features Keita…
Manu Dibango is one of the first African musicians to score a worldwide hit with his '72 release "Soul Makossa", paving the way for many other artists to follow. This concert switches from Rock to Reggae to Jazz, and features an excellent line-up of…
Egberto Gismonti is a totally exotic musical missionary from Brazil who seldom gives solo concerts. Here he gives an unforgettable performance on piano and 8-string guitar. On Guitar: 28' On piano: 26
For more than 20 years, this quartet has been a musical melting pot, artfully blending American jazz, European classics, Indian and African music into an instantly recognizable, meditative sound experience.
Cuba Cuba
"Jazz en clave" is a septet especially put together by Chucho Valdés for the Jazz Open Stuttgart 1999, and features artists like Giovanni Hidalgo, Claudio Roditi and Juan Pablo Torres who together with Michel Camilo belong to the best Latin Jazz…
Don Cherry`s "Multikulti"
Don Cherry is a musician of great versatility who has created an endless variety of styles, influencing generations of musicians for years. "Multikulti" presents a never-before heard mixture of international sounds, from Mainstream Jazz to Reggae, in…
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Sweepstakes - Disclaimer
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No one is laughing now (continued)
Boston - It hasn't taken long for the reform agenda of Ukraine President Volodymyr Zelensky to bear fruit. He has assembled a new cabinet dominated by young political outsiders, and the new prime minister, Alexei Goncharuk, shares Zelensky's reform-minded zeal.
Zelensky's Servant of the People Party, which won an absolute parliamentary majority in July, set forth ambitious goals at its first meeting on August 29. The first big accomplishment was to eliminate immunity for parliamentary deputies, and the short-term legislative "to-do" list* is no less impressive:
2020 draft budget by September 15
Land reform draft bill by October 1 and passed by December 1
Draft legislation on framework for public-private partnerships (PPPs) by October 1
"Split bill" (International Monetary Fund benchmark) by October 1
Draft legislation to combat corporate raiding by October 1
State-owned small- and medium-enterprises (SMEs) up for sale by December 1 via electronic auction system
Privatization plans for large state-owned enterprises (SOEs) to be drawn up by December 1
Capital controls completely removed by the end of 2019
Draft legislation to liberalize the labor market by January 1, 2020
2,000 new judges vetted and hired by January 1, 2020
Other good news for the country has emerged recently as well. The central bank lowered its policy rate by 50 basis points to 16.5%, following its July cut, while Fitch upgraded Ukraine's sovereign debt from B- to B on Friday.
Zelensky also scored a significant win with the prisoner swap with Russia over the weekend, in which 35 people on each side were exchanged following weeks of negotiations. This a rare agreement between the two countries and is seen "as a condition for further talk." Russia and Ukraine have been engaged in a long-running conflict over control of eastern Ukraine, following the Russia's 2014 invasion of Crimea. Ending the conflict and getting the prisoners back was a major campaign promise.
Bottom line: Even optimists can be justifiably surprised at the comprehensive scope of parliament's plans. If Zelensky and the legislature can maintain momentum, this could be a real opportunity for reform in Ukraine.
Publication details: Wednesday, September 11, 2019 10:00 AM
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Japan Panorama
Tokyo, Japan's modern heart, iconic Mt. Fuji, the world heritage temples & gardens of Kyoto, Nara & Osaka; stay in deluxe 4 & 5 star hotels
from$4399Tour + Flights 10days
price per person, double occupancy,* based on Sep 3, 2020 departure from LAX
$400 Instant Savings. Expires Feb 27, 2020.* All prices reflect savings.
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Style Small Group TourTravel with a small, intimate group of no more than 24 likeminded travelers (and often much fewer), escorted by an English speaking guide and/or tour manager for some or all of your journey. More of these packages
Dedicated tour escorts & guides throughout
Departures June – October 2020 Group Size 24 travelers max
Themes History & Culture, Grand Tours
Activity Level Recreational
What to Expect This moderately-paced, locally hosted tour includes a reasonable amount of walking or hiking and requires an average level of physical fitness.
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Select a date Jun 4 - Jun 13, 2020 Sep 3 - Sep 12, 2020 Oct 15 - Oct 24, 2020 Apr 9 - Apr 18, 2020 May 7 - May 16, 2020
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What to expect | Your Privacy
Japan is a wonderful and fascinating destination that can tend to be very expensive—unless you're traveling with Friendly Planet! Our affordable Japan tour package lets you explore this ancient yet modern country for a truly remarkable price without compromising on quality. Fly to Japan via Singapore Airlines, voted the world's #1 airline for safety, comfort and service. Stay at beautiful and well-located 4- & 5-star hotels throughout the country, enjoying a lavish buffet breakfast daily.
Visit Tokyo, Japan's modern capital, Kyoto, ancient capital for over 1000 years, and Osaka, considered Japan's spiritual heartland, plus lots of other sites in between on this exceptional 10-day tour of Japan.
Round trip flights from Los Angeles via Singapore Airlines non-stop jet service including fuel surcharges and taxes and fees
All intra-Japan ground transportation
8 nights Deluxe and superior first class hotels with private bath
11 Meals: 8 breakfasts, 2 lunches & 1 dinner
Comprehensive, fully escorted touring program including entrance fees
Professional English-speaking local guides
Added-Value: ¥2,000 pre-paid Suica transit/e-money card
Kamakura & Enoshima Bay with lunch
Hiroshima & Miyajima
Enjoy a breathtaking view of the city from Tokyo Skytree, the tallest tower in the world.
Wander through the alluring East Gardens of the historic Imperial Palace, admiring the ancient castle walls and ruins.
Waft incense over your body for improved health at Sensoji Temple, Tokyo's oldest and most significant temple.
View the 12,000 foot high Mt. Fuji, recognized around the world as a symbol of Japan.
Ascend Mt. Komagatake via the Komagatake Ropeway and enjoy sweeping views of Hakone National Park and Mt. Fuji.
Zoom past Japan’s rolling countryside on a high-speed journey to Kyoto aboard the Shinkansen.
Marvel at the Golden Pavilion whose three stories each reflect a different architectural style and are covered in gold leaf.
Visit Osaka Castle, an impressive fortification that played a major role in the unification of the country during the sixteenth century of the Azuchi-Momoyama period
Indulge a special farewell dinner in Osaka with your fellow travelers.
1 Depart USA
2 Arrive Tokyo, Japan
3 Tokyo
4 Mt. Fuji & Hakone
5 Tokyo or Kamakura & Enoshima Bay excursion with lunch
Optional Excursion: Full Day Kamakura & Enoshima Bay with Lunch, +$180
6 Tokyo & Kyoto
8 Kyoto or optional Hiroshima & Miyajima excursion
Optional Excursion: Full Day Hiroshima & Miyajima, +$450
9 Kyoto, Nara & Osaka
10 Osaka & Depart Tokyo/Arrive USA
Instant Savings: Get $400 off if you book by Feb. 27, 2020!
Dates & Prices, with flights
Dates Regular
Price Instant
Savings Your
Departs U.S.: Thu, Apr 9, 2020
Finishes: Sat, Apr 18, 2020
Apr 9 – Apr 18 $4999 – – Closed
Departs U.S.: Thu, May 7, 2020
Finishes: Sat, May 16, 2020
May 7 – May 16 $4699 – – Closed
Departs U.S.: Thu, Jun 4, 2020
Finishes: Sat, Jun 13, 2020
Book by Thu, Feb 27, 2020 (midnight ET) to get the Instant Savings! Jun 4 – Jun 13 $4899 –$400 $4499 Book
Departs U.S.: Thu, Sep 3, 2020
Finishes: Sat, Sep 12, 2020
Book by Thu, Feb 27, 2020 (midnight ET) to get the Instant Savings! Sep 3 – Sep 12 $4799 –$400 $4399 Book
Departs U.S.: Thu, Oct 15, 2020
Finishes: Sat, Oct 24, 2020
Book by Thu, Feb 27, 2020 (midnight ET) to get the Instant Savings! Oct 15 – Oct 24 $4799 –$400 $4399 Book
If you want a few extra days to explore on your own, we may be able to arrange for you to stay later than the scheduled dates, including extra hotel nights and separate airport transfers, for an additional charge. Ask us about prices and availability when (or after) you reserve. More information Want to extend your trip?
Flights & Departure Cities
Los Angeles (LAX) included
This package includes round-trip flights from the city listed above. Please review the flight schedule, especially if you're booking connecting flights.
Day 1 Depart USA
Depart on your overnight flight to Tokyo
Day 2 Arrive Tokyo, Japan
Arrive in Tokyo, meet your guide and transfer to your hotel
Imperial Hotel Tokyo
Full Day Itinerary
Arrive early this evening in Tokyo, one of the world's main economic centers and Japan's modern capital, as well as its largest city. Your tour host will meet you upon arrival and escort you to your deluxe, centrally located hotel. En route, you'll have your first glimpse of the stunning, modern skyline and glittering neon-lit streets that are quintessential Tokyo. You'll also receive a short briefing about details of your tour of Japan.
Day 3 Tokyo
City tour of Tokyo including Tokyo Skytree, Asakusa Kannon, Edo Museum and the Imperial Palace's East Garden
Afternoon at leisure
Imperial Hotel Tokyo Breakfast & lunch
After breakfast, set out on a guided tour to explore some of Tokyo's main sites. Begin at the Tokyo Skytree, from which you'll enjoy a wonderful view of the city. Continue to Sensoji, or Asakusa Kannon, dedicated to Kannon, the Buddhist deity of mercy and compassion. Sensoji is one of the most popular sights in Tokyo, yet it's delightfully serene. Smoke from its incense cauldron is said to be beneficial to health, especially the part of the body onto which it is rubbed, and you will see many people doing this before going to pray.
Then, stroll Nakamise shopping street, which stretches over approximately 250 meters from the main grounds of Sensoji Temple. It is lined with more than 50 shops, which offer local specialties and souvenirs. Afterwards, enjoy a traditional lunch at a local restaurant.
Later, visit the Edo Museum and learn about the culture and history of Japan. Proceed to the historic Imperial Palace, which dates back to the 15th century and is the former site of Edo Castle and the present residence of the Emperor of Japan. Visitors are not permitted inside this very private residence of royalty, but you will enjoy a walk through the beautiful East Gardens, with views of the ancient castle walls and ruins.
This afternoon is free for independent touring. We suggest a visit to the The Ginza, Tokyo's most famous up-market shopping, dining and entertainment district, featuring numerous department stores, boutiques, art galleries, restaurants, night clubs, cafes and Kabuki Theater.
Day 4 Mt. Fuji & Hakone
Enjoy a beautiful panoramic drive from Tokyo to Mt. Fuji
Drive to the 5th station and see gorgeous views of the surrounding countryside
Continue to Hakone for lunch and a scenic cruise on Lake Ashi
Board the Komagatake Ropeway and ascend Mt. Komagatake
Return to Tokyo late this afternoon
Today you'll enjoy a beautiful panoramic drive from Tokyo to Mt. Fuji, an almost perfectly conical volcano that is recognized around the world as a symbol of Japan. It stands over 12,000 feet high and is beautifully snow-capped in winter. Drive to the 5th station, a 5 to 6-hour trek from the summit for experienced hikers, where you'll enjoy gorgeous views of the surrounding countryside. Continue to Hakone, a hot springs resort town located in the Fuji Hakone Izu National Park, where you'll enjoy an included lunch. After lunch, take a scenic cruise on Lake Ashi, a slender body of water formed in the Hakone caldera some 400,000 years ago. Board the Komagatake Ropeway for an incredibly picturesque ascent up Mt. Komagatake and a sweeping view of Hakone National Park and Mt. Fuji. Return to Tokyo late this afternoon.
Day 5 Tokyo or Kamakura & Enoshima Bay excursion with lunch
Full day at leisure in Tokyo
Imperial Hotel Tokyo Breakfast
Enjoy a day at leisure to explore Tokyo on your own. Your hotel is conveniently located in the heart of Tokyo, adjacent to the Tokyo Tower and historical Zojo-ji temple and within easy access to the fashionable shopping districts of Ginza and Roppongi.
You'll depart after breakfast from your hotel to the Hamamatsucho bus terminal. Start your tour by tasting some of Japan's famous powdered matcha green tea and confectionery in the Jomyo-ji Temple. You will enjoy the view of the temple's Japanese rock garden in the highly refined and tranquil tea room that was constructed over 400 years ago. Walk through the grounds of Hokoku-ji Temple, known as the bamboo temple for its beautiful bamboo grove. Visit Kotoku-in Temple which houses a towering, 43 foot tall Buddha statue known as one of the three Great Buddha statues in Japan. Lunch will be a Japanese-style meal. Visit Enoshima, a getaway island popular year-round for its cool ocean breezes. Cross over the 2,000 foot long bridge that connects the island of Enoshima with the mainland and walk along Benzaiten Nakamise Street which is lined with intriguing shops. Afterward, take the Enoshima Escar (outdoor escalator, ascending only) which will whisk you easily up to Enoshima Shrine. Enjoy the beautiful ocean views from the Enoshima Shrine. The Enoshima Escar goes uphill only. There are no escalators to go down. Passengers who opt not to take the Enoshima Escar may explore Benzaiten Nakamise Street which is a lively street lined with restaurants and shops. This is a regularly-scheduled, English-speaking bus tour. Tour participants will arrive to the Hamamatcucho bus terminal where the tour begins. The tour ends in Tokyo at Shinjuku, where you have to make your own way back to the hotel or stay and experience some of Tokyo's famous nightlife.
Day 6 Tokyo & Kyoto
Travel to Kyoto aboard the Shinkansen, Japan's bullet train
Enjoy a walking/subway orientation tour of Kyoto
Balance of the day at leisure
Hotel Granvia Kyoto Breakfast
Set out this morning on a high-speed adventure aboard the Shinkansen, Japan's bullet train. This fast, quiet train, itself a tourist draw, links the major cities in Japan efficiently, while reaching speeds of over 170 miles per hour. You'll arrive in Kyoto quickly and comfortably, ready to enjoy the beauty and fascination of this very special city.
Upon arrival, meet your guide and check into your hotel. After check-in, enjoy a walking/subway orientation tour of Kyoto. Visit the Nishiki Market, a 400 meter long street lined with small stands and shops; the Ponto-cho area which is the local restaurant district and Kyoto's underground department store. The balance of your day is at leisure to explore the temples, shrines, gardens and other beautiful sites located within walking distance of your hotel. Enjoy some shopping time at Kyoto's underground department store where you'll enjoy the sights and sounds of typical Japanese life.
City tour of Kyoto including Kiyomizu Temple, Golden Pavilion, Nijo Castle and the Heian Jingu Shrine
This ancient city, home to almost 1.5 million people, was the capital of Japan for more than a thousand years and still is considered the country's spiritual capital. On today's full day tour, you'll visit the main attractions of the city, beginning with Kiyomizu Temple. Located on a hillside at the east edge of the city and famous both for its waterfall and for the stunning view from its vast wooden terrace. The temple is particularly beautiful in April, when cherry blossoms abound, and in November, when maple leaves show their autumn colors.
Proceed to the Golden Pavilion (Kinkakuji Temple), which is covered in gold leaf and whose three stories each reflect a different architectural style. The small lake nearby adds to the glimmer, and while no one is allowed inside, you can take pictures that are sure to be among your favorite and most memorable images of Japan. The actual building is a perfect reconstruction, erected after a disaffected monk set fire to the original, centuries-old wooden structure in 1950.
Continue to the fascinating Handicraft Center, where you'll be greeted by five colorful floors offering for sale beautiful Japanese arts and handicrafts including pearls, lacquer ware, dolls, toys, kimono (including antique kimono), woodblock prints, pottery, paper products, swords, lanterns, silk and textile goods, painted scrolls, music boxes and much, much more. Next, make your way to the 17th century Nijo Castle. You can see the architecture change as you go from the most public spaces to the private chambers of the shogun, which were protected by a highly imaginative security system comprised of floorboards deliberately built to squeak when walked upon. Your last stop of the day is a visit to the Heian Jingu Shrine, a 5/8 scale reproduction of the Heian Palace, dedicated to the spirits of the first and last Emperors who reigned in the city of Kyoto. Here you'll have an opportunity to walk around the shrine's beautiful court and have a photo stop in front of the giant Torii Gate.
Day 8 Kyoto or optional Hiroshima & Miyajima excursion
Full day at leisure in Kyoto, or join an optional excursion to Hiroshima & Miyajima
You'll depart after breakfast and travel by bullet train to Hiroshima. Take a short ferry ride to the island of Miyajima, just off the coast from Hiroshima. Here, you'll visit the UNESCO World Heritage site of the Shrine of Itsukushima, one of the most photographed sites in Japan. Constructed in 593 to honor the fishing gods, the shrine sits on wooden piers over the water. The orange paint on the shrine's entrance gate provides for a stunning color contrast against the crystal blue waters of the bay. After touring the shrine of Itsukushima, you will have time for lunch on your own on Miyajima at a local restaurant before returning to Hiroshima by ferry. Afterward, visit the Hiroshima Bomb Dome, a skeleton of a building that survived the atomic bomb blast in 1945. Continue across the street to the Peace Memorial Park, where you'll find a moving memorial to the victims of the bomb as well as a museum that offers a compelling and important history of the horrors of war. You will have time to explore the Hiroshima Peace Memorial Museum on your own before returning to Kyoto. This museum is a monument that celebrates the desire for long life and happiness. This is a regularly-scheduled, English-speaking bus tour. Tour participants must make their own way to the tour desk at Kyoto Station, a short walk from your hotel. (Note: The Shrine of Itsukushima's large torii gate will not be visible beginning in June 2019, due to renovations. The Hiroshima Peace Memorial Museum's main building is currently being renovated through Spring 2019. The fully renovated, East building will be open to visitors and includes displays from the Main Building.)
Day 9 Kyoto, Nara & Osaka
Drive to Nara, one of the earliest capitals of Japan
Visit Todaiji Temple and the Kasuga Shrine
Continue to Osaka and see Osaka Castle and Dotonbori Street on an afternoon city tour
Enjoy a farewell dinner
Osaka Marriott Miyako Breakfast & dinner
After breakfast, drive to Nara, one of the earliest capitals of Japan. Visit Todaiji Temple, whose Buddha is the largest bronze statue in the world, and whose main structure is the world's largest wooden building. The temple sits in a huge park where small deer have free rein to mingle with visitors and beg for treats that you can buy from local vendors for a few yen. Another delight is Kasuga Shrine, festooned with thousands of paper lanterns.
This afternoon, continue your drive to Osaka, considered Japan's spiritual heartland. The site of one of the earliest capitals of the country, it remains a vital center for trade and entrepreneurial culture. On an afternoon city tour, visit Osaka Castle, one of Japan's most famous castles, which played a major role in the unification of the country during the sixteenth century of the Azuchi-Momoyama period. The castle is situated on a plot of land roughly one kilometer square and is a popular spot during festival seasons; especially when the cherry blossoms bloom and the sprawling castle grounds are covered with food vendors and taiko drummers.
Continue to Dotonbori Street, a former pleasure district now famous for its theatres, shops, and restaurants and the many colorful neon and mechanized signs, including snack/candy manufacturer Glico's giant electronic display of a runner crossing the finish line. Enjoy strolling the long street and take advantage of the opportunity to shop for last-minute souvenirs. Finally, join your fellow travelers for a special farewell dinner.
Day 10 Osaka & Depart Tokyo/Arrive USA
Board the bullet train from Osaka to Tokyo
Transfer to Narita Airport to board your return flight
Arrive in the USA later today
As a prestigious member of the Leading Hotels of the World, the 5-star Imperial Hotel Tokyo boasts an impressive historic pedigree. Centrally located just south of Tokyo Station and the Imperial Palace grounds, the property has long drawn a high-profile clientele. Rooms are situated in the main building or in the gleaming tower, and many look across 40-acre Hibiya Park, the Imperial Palace or the dazzling Ginza neighborhood. The hotel also features a number of health and beauty options including a barber, nail salon, cosmetic dentistry and luxurious spa treatments. The Imperial hotel’s state-of-the-art fitness center, pool and sauna facilities are available to hotel guests for a small daily usage charge.
Hotel Granvia Kyoto
Hotel Granvia Kyoto is found within the exceptional architectural structure of the JR Kyoto Station Complex. Because the hotel is in the center of the world-renowned international tourist destination of Kyoto, it is in walking distance of many popular temples, castles, and gardens. There are several other tourist attractions you can get to just by taking a short ride on the multiple public transportation options available. Hotel Granvia Kyoto features 534 simple yet elegantly decorated rooms designed to meet your traveling needs. There are several suites as well as 2 exclusive Granvia floors. The multiple diverse restaurants in the hotel serve many European dishes ranging from full course French meals to authentic Italian dinners. Traditional Japanese cuisine can be experienced in the many dining choices that have become some of the finest in Japan. You can enjoy the inspiring views of the ancient city while you have a drink and listen to live music alongside the nostalgic decor of the hotel's bars.
Osaka Marriott Miyako
Osaka Marriott Miyako Hotel occupies the 38th to 57th floors in the tallest building complex in Osaka, Japan. The hotel’s location makes it easy to explore the exciting city; easy access to the every corner by subway and regional rail, and only 30 minutes from Kansai International Airport.The Osaka Marriott Miyako Hotel also features a number of on-site shops for your convenience as well as complimentary access to a 24-hr fitness center.
In the unlikely event that a particular hotel is not available, a similar or better hotel may be substituted.
What should I know before I go? We've compiled a comprehensive checklist, including information on how to pay your balance due, flights & transfers, packing & luggage, and more.
Do I need a visa or other documents? Are there any entry requirements? Please review the visa & entry requirements.
Can I make changes to my trip? Want to upgrade your seats? Stay a few extra days? Something else? Just ask!
Can I bring my kids? Are there any age restrictions? To book this package, you must be 18 or older. Your traveling companions must be 8 or older at time of travel.
Should I purchase travel protection? Yes! You can purchase our travel protection plan with your deposit or final payment. It may not be purchased before then.
What's the fine print? Review the terms & conditions for this package.
What should I know about Japan? Check out our guide for practical travel tips, the best time to go, videos, and more.
More Common Questions
Common Questions Answers to our travelers' most frequently asked questions.
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Relation between MTHFR (Methylenetetrahydrofolate Reductase) gene functional polymorphisms and magnitude of Recurrent Pregnancy Losses (RPL) among women with low socio-economic status in Asian Indians
Dhatri Madduru
Supriya K
Kethora Dirsipam
Prasanna Latha Komaravalli
Syed Sayeeduddin
Parveen Jahan
Received: May 13, 2019
Accepted: May 30, 2019
Genet.Mol.Res. 18(3):
Methylene tetrahydrofolate reductase (MTHFR); Recurrent pregnancy loss; Polymorphisms; Magnitude; Low socio-economic status.
Recurrent pregnancy loss (RPL) is an obstetric complication observed in women which is characterized by two or more consecutive losses of fetal product before 20 weeks of gestation. It is affecting approximately 15-20% of clinically recognized pregnancies (Shiny et al., 2015). Pregnancy outcome is influenced by maternal genetic constitution and environmental factors such as lifestyle, nutritional status, inter-pregnancy interval, smoking, alcohol consumption, coffee consumption, stress, physical activity, socio-economic status etc. (Speroff et al., 1999; Seo and Sang, 2009). During pregnancy, fetal development is associated with rapid cell division and nucleic acid synthesis which is accomplished vitally by folate (vitamin B9) which also acts as a substrate for various enzymatic reactions involved in amino acid synthesis and vitamin metabolism (James et al., 2011).
Folate deficiency results in hyperhomocysteinemia, a condition where elevated levels of homocysteine that can be detected in plasma which is detrimental for fetus (Theresa and William, 2000). It could be due to low dietary folate intake or owing to defects in genes involved in folate metabolism such as Methylenetetrahydrofolate reductase (MTHFR) located in the short arm of chromosome 1 (1p36.3). This enzyme catalyzes the conversion of 5, 10-methylenetetrahydrofolate (5,10-MTHF) into 5-methyltetrahydrofolate (5-MTHF), which provides the single-carbon for homocysteine in methionine synthesis (Kobashi et al., 2005; Wu et al., 2012). The most common genetic polymorphisms of MTHFR gene are (rs1801133 (C677T) and rs1801131 (A1298C)) which have been extensively addressed in various human diseases such as neural tube defects (Steegers et al., 1992), Down’s syndrome (Cyrus et al., 2009), cardio- vascular disorders (Kluijtmans et al., 1996), including Recurrent Miscarriages (Quere et al., 1998). The rs1801133 (C677T) is a non-synonymous substitution of alanine to valine in the protein as a result of transition in exon-4 that renders the enzyme, thermolability and decreased activity.
On the other hand, rs1801131 (A1298C) polymorphism is a result of missense mutation in exon-7 due to a transversion which lead to a substitution of glutamate with alanine, without overtly affecting enzyme activity (Van der put and Blom, 2000). Association of these polymorphisms in RPL have been reported previously from various population groups from India (Saraswathy et al., 2012), however, there were no studies in view of the severity or magnitude of RPL. Hence, the present study was intended to investigate the influence of MTHFR gene functional polymorphisms with respect to susceptibility and the magnitude of RPL among women with low socio-economic status.
For the present study, a total of 221 subjects that include 102 patients and 119 controls belonging to low socio-economic status were enrolled. The diagnosis of women with RPL was made based on documented history of at least two or more spontaneous, consecutive miscarriages before 20 weeks of gestation. However, women with induced abortions and abortions due to any other known complications were excluded from the study (Shiny et al., 2015). Women having completed at least two successive pregnancies and no history of spontaneous miscarriages, were randomly selected as control group. The patients were recruited from Modern Government Maternity Hospital, Petlaburj, Hyderabad, India and Sri Venkata Sai (SVS) Hospital, Mahbubnagar, India whereas, the controls from health clinics. We recruited all the subjects following Udai Pareek revised scale (Singh et al., 2017).
The clinical and general characteristic aspects of the study group were collected using a structured questionnaire. The social aspects included consanguinity, nutrition (good and poor eating habits) and toddy consumption (intake and non-intake) (a locally available alcoholic drink). Clinical characteristics included hemoglobin (Hb) levels (≤ 11g/dl and >11g/dl), age at marriage (≤ 18years and >18 years), age at first conception (<18 years and ≥18 years), menstrual status (regular and irregular), type of abortion (primary and secondary aborters), number of abortions (≤ 3 and >3) and Body Mass Index (BMI) (normal 18-23 kg/m2 and abnormal <18 &>23 kg/m2). The familial characteristics included family history of abortions and common health complications such as diabetes, hypertension etc. Blood samples were collected after obtaining written informed consent from the study participants. The study got approval from the Institutional Ethical Committee, Osmania University, Hyderabad, India.
MTHFR Genotyping
Genomic DNA was isolated from blood samples using standard established protocol in our lab (Tippisetty et al., 2011). PCR-RFLP was carried out for MTHFR gene polymorphisms using specific primers, FP (Forward Primer) 5'-TTTGAGGCTGACCTGAAGCACTTGAAGGAG-3' and RP (Reverse Primer) 5'-GAGTGGTAGCCCTGGATGGGAAAGATCCCG-3' for rs1801133 (Ramadevi et al., 2004) and FP 5'-CTTTGGGGAGCTGAAGGACTACTAC-3' and RP 5'-CACTTTGTGACCATTCCGGTTTG-3' for rs1801131 (Bioserve Biotechnologies, Hyderabad, India).
Amplification reactions were carried out in a Thermocycler (Eppendorf, USA Scientific Inc.) with a final volume of 25 μL reaction mixture, containing 100 ng of genomic DNA, 10pM of each primer, 2.0 mM of dNTPs (Lab pro, India), 1.5 mM of MgCl2, 10X PCR buffer and 0.5U Taq DNA polymerase (Lab pro, India). PCR conditions comprised an initial denaturation step at 95ºC for 5 minutes, followed by 30 cycles of 94ºC for 30 seconds, annealing temperature of 65ºC (rs1801133) and 57ºC (rs1801131) for 45 seconds, and extension at 72ºC for 45 seconds. The final extension was at 72ºC for 5 minutes and holds at 4ºC.
The Oligonucleotide primers generated a PCR product of 173 base pair (bp) and 163 bp for rs1801133 and rs1801131 polymorphisms respectively. The PCR products were digested by using Hinf I for C677T and MboII for A1298C for one and a half hours in a dry bath (Genei, India). The digested products were then separated on 10% PAGE (Poly Acrylamide Gel Electrophoresis) and stained with ethidium bromide and observed under gel documentation system (Bio-Rad, India). For the C677T polymorphism, the substitution of T allele at nucleotide position 677 creates a Hinf I restriction site with subsequent cleavage of the original 173 bp PCR product into 125 and 48 bp fragments. The A1298C mutation abolishes the restriction site of MboII, resulting in the merger of 56 and 28 bp fragments into 84 bp fragment (Figures 1A and 1B).
Figure 1: A) PCR products of MTHFR C677T fragment digested with Hinf- I restriction enzyme. C677T mutation analysis. Lane 1, 2, 5 & 7, CC (normal homozygote); lane 3,4 & 6, CT (heterozygote) and lane 8, 50 bp DNA ladder. B) PCR products of MTHFR A1298C fragment digested with Mbo- II restriction enzyme. A1298C mutation analysis. Lane 1, 50 bp DNA ladder; lane 2,3,4 & 5, AC (heterozygote); lane 6 & 8, CC (mutant homozygote) and lane 7, AA (normal homozygote).
Distribution of allele, genotype frequencies and Hardy-Weinberg equilibrium (HWE) of patient and control groups were analyzed by χ2 test. Risk estimation was calculated by Odds ratio (OR) with 95% confidence intervals (CI) using online calculator. Data analysis was carried out by SPSS version 18.0 (spss.en.softonic.com), Chicago, USA wherever required. Statistical significance was defined as a two-sided p-value < 0.05. We also performed analysis on genotype combinations using online tools.
The present case-control study includes 102 women with RPLs and 119 normal healthy fertile women. All RPL women were in the age range of 17 to 40 years and the number of miscarriages ranging from 2 to 10. A total of 77 (76%) women were primary aborters i.e., those who have lost all previous pregnancies, and remaining were secondary aborters i.e., those who have had at least one successful pregnancy. Women in the control group were in the age range of 18 to 52 years with no history of miscarriage. The clinical and general characteristics of patient and control groups were summarized in the Tables 1 and 2 respectively. The mean BMI, age at marriage and age at first conception were significantly differed between the two groups (p<0.05). Ten percent of patients showed family history of abortions, however none from the control group. It can be highlighted that 13% of the patients were with higher magnitude of pregnancy losses (i.e., >3).
Controls (119)
BMI (kg/m2) 21.64 ± 3.49 20.21 ± 2.65 < 0.01
Hb (g/dl) 9.78 ± 1.23 9.43 ± 1.45 0.052
Age at marriage (years) 19.12 ± 3.76 16.76 ± 2.76 < 0.01
Age at first conception (years) 20.09 ± 3.77 18.20 ± 2.82 < 0.01
No. of abortions 2.73 ± 1.05 - -
Table 1: Clinical features of the study group.
Patients (N=102)
Controls (N=119)
Hb levels (g/dl)
≤ 11 92 (90%) 113 (95%)
>11 10 (10%) 6 (5%)
Age at marriage (in years)
≤ 18 38 (37%) 66 (55%)
>18 64 (63%) 53 (45%)
Age at first conception (in years)
< 18 (13-17) 23 (23%) 40 (34%)
≥ 18 (18-34) 79 (77%) 79 (66%)
Menstrual status
Regular 91 (89%) 117 (98%)
Irregular 11 (11%) 2 (2%)
Consanguinity
Yes 27 (26%) 31 (26%)
No 75 (74%) 88 (74%)
Good 88 (86%) 112 (94%)
Poor 14 (14%) 7 (6%)
Type of abortion
Primary aborters 77 (76%) 0 (0%)
Secondary aborters 25 (24%) 0 (0%)
Number of abortions
≤ 3 89 (87%) 0 (0%)
>3 13 (13%) 0 (0%)
Health complications
Yes 9 (9%) 0 (0%)
No 93 (91%) 119 (100%)
Family history of abortions
Yes 10 (10%) 0 (0%)
No 92 (90%) 0 (0%)
Social habits (toddy)
Intake 10 (10%) 24 (20%)
Non- intake 92 (90%) 95 (80%)
BMI (kg/m2)
<18 and >23 (Low and high) 53 (52%) 45 (38%)
18-23 (Normal) 49 (48%) 74 (62%)
Table 2: General Characteristics of the study group
MTHFR gene polymorphisms
The genotype and allele frequencies for C677T (rs1801133) polymorphism did not differ significantly between patients and controls (p>0.05). On the other hand, for A1298C (rs1801131) polymorphism, the incidence of genotype and allelic classes displayed a significant variation between RPL patients and controls (p<0.05). The genotype distribution of both patient and control groups deviated from HWE (p<0.05) for C677T polymorphism whereas, it is in accordance with HWE (p>0.05) for A1298C polymorphism (Table 3).
MTHFR C677T
Control vs. Patient groups
Comparison of groups
OR (95% CI)
CC 76 (64) 68 (67) CC vs. CT 1.13 (0.64-1.97)
CT 43 (36) 34 (33)
TT 0 (0) 0 (0) CT vs. CC 0.88 (0.50 –1.54)
Χ2 0.19
C 0.82 0.83 C vs. T 1.07 (0.516-2.223)
T 0.18 0.17
Χ2 0.03 T vs. C 0.93 (0.44-1.93)
HWE 5.78* 4.08*
MTHFR A1298C Control vs. patient groups MTHFR A1298C Control vs. Patient groups
n (%) Patients
n (%) Comparison of groups OR (95% CI)
AA 47 (40) 21 (21) AA vs. AC+CC 0.39* (0.21-0.72)
AC 53 (44) 48 (47)
CC 19 (16) 33 (32) AC vs. AA+CC 1.10 (0.65-1.88)
Χ2 12.72*
A 0.62 0.44 CC vs. AA+AC 2.51* (1.32-4.78)
C 0.38 0.56
Χ2 6.50* A vs. C 0.48* (0.27-0.84)
HWE 0.38 0.21 C vs. A 2.08* (1.18-3.65)
* p-value is statistically significant i.e., <0.05; NS: Not Significant.
Table 3: Allele and Genotype frequency distribution of MTHFR C677T and A1298C polymorphisms among RPL patients and controls
Stratified data based on the magnitude of pregnancy losses (i.e., ≤ 3 or >3) revealed a significant difference with respect to genotype and allele frequencies of C677T polymorphism whereas, no association was observed for either genotypes or allelic classes of A1298C polymorphism (Table 4).
≤ 3 vs. >3 RPL groups
≤ 3 (N=89)
>3 (N=13)
CC 63 (71) 5 (39) CC vs. CT 0.25* (0.07-0.86)
CT 26 (29) 8 (61)
TT 0 (0) 0 (0) CT vs. CC 3.87* (1.15-12.9)
Χ2 5.33*
C 0.85 0.69 C vs. T 0.39* (0.19-0.78)
Χ2 7.23* T vs. C 2.54* (1.27-5.09)
HWE 2.60 2.56
MTHFR A1298C ≤ 3 vs. >3 RPL groups MTHFR A1298C ≤ 3 vs. >3 RPL groups
n (%) >3 (N=13)
AA 18 (20) 3 (23) AA vs. AC+CC 1.18 (0.29-4.75)
AC 45 (50) 3 (23)
CC 26 (30) 7 (54) AC vs. AA+CC 0.29 (0.07-1.13)
A 0.46 0.35 CC vs. AA+AC 2.82 (0.86-9.22)
Χ2 2.51 A vs. C 0.63 (0.35-1.11)
HWE 0.03 3.12 C vs. A 1.58 (0.89-2.79)
* p-value is statistically significant i.e. <0.05; NS: Not Significant.
Table 4: Allele and Genotype frequency distribution of MTHFR C677T and A1298C polymorphisms in severity among RPL patients (≤ 3 and > 3)
Combined Genotype Analysis
In the combined genotype analysis, CC-CC genotype emerged as a significant risk genotype combination (OR 2.82, 95% CI 1.26-6.32, p<0.05), while CT-AA genotype appeared to be an appreciable protective combination (OR 0.24, 95% CI 0.07-0.75, p <0.05) against RPL. Considerable elevated frequency of CT-CC genotype combination was seen in women with >3 pregnancy losses compared to women with ≤ 3 pregnancy losses (31% vs. 9%) (OR 4.5, 95% CI 1.12-17.9, p<0.05) (Figures 2A and 2B).
Figure 2: Graphical representation of distribution of combined effect of both MTHFR C677T and A1298C polymorphisms in Recurrent Pregnancy Loss (RPL) Cases and controls and severity of disease.
Overall results reflect that, MTHFR C677T polymorphism has no significant effect on disease vulnerability but were predisposed to have higher magnitude of pregnancy losses (>3) with nearly a five-fold risk. In contrary, A1298C polymorphism has a link with RPL susceptibility but not with respect to magnitude of the RPL.
MTHFR is a critical enzyme for the production of 5-MTHF, a circulating form of folate that is vital for re-methylation of homocysteine to methionine and finally to S-adenosyl methionine (SAM), a major methyl group donor to biomolecules such as DNA which is synthesized at a high rate during embryonic development. These methyl groups are essential for appropriate methylation patterns, failing which can adversely affect embryogenesis, leading to developmental malformations like defective chorionic villous vascularization. Nutritional basis of folate deficiency or the genetic mutations in the MTHFR gene or both the factors may cause the elevated homocysteine, a risk factor for thrombosis in placenta and impaired endothelial vasomotor function consequently disquieting implantation leading to early pregnancy loss. It shows that methylation is sensitive to both varying environment and genetic changes or modified by gene-environment interactions which may significantly contribute to embryonic development (Mohamed et al., 2014; Wael et al., 2016).Two most studied polymorphisms i.e. C677T (NCBI SNP (Single Nucleotide Polymorphism) ID: rs1801133) and A1298C (NCBI SNP ID: rs1801131) were well linked with the activity of MTHFR which were shown to impact several diseases including adverse pregnancy outcomes. However, there is a scantiness of reports with respect to these polymorphisms and magnitude of pregnancy losses particularly among women with low socio-economic status. Hence, the present case-control study is an attempt to investigate the relationship between MTHFR gene polymorphisms, C677T and A1298C with the severity of RPL in Asian Indians. Our study showed lack of association of C677T polymorphism with RPL, which corroborated with reports from India as well as Polish and Chinese populations (Ren and Wang, 2006; Seremak et al., 2010; Saraswathy et al., 2012).
Very low frequency of mutant genotype (TT) was reported from different parts of India (Anil Kumar et al., 2018; Vandana Rai 2016; Seerat et al., 2012; Saraswathy et al., 2012) however, the complete absence of this genotype (TT) was observed in the present study suggesting the severe pathogenic nature of this polymorphism in homozygous condition. In contradiction to the above reports, Wang et al., (2004) reported a significant decrease in the frequency of CC genotype and increase in TT genotype in unexplained recurrent spontaneous abortion patients compared to controls in Chinese population (Wang et al., 2004). The difference in the results could be due to different environmental factors and ethnicity.
The second polymorphism A1298C was shown to be allied with altered distribution of intracellular folate metabolites and its concentration (Cande et al., 2007). With respect to this single nucleotide variant, the AA genotype and A allele showed a significant protective role against RPL. Whereas, the homozygous CC genotype and C allele revealed a 2.5- and 2.08-fold increased risk towards RPL respectively. A meta-analysis conducted based on electronic data base by Nair et al., (2013) reported an association of both alleles and genotypes of A1298C variant with RPL susceptibility (Nair et al., 2013). Similar studies from North India and other populations also show a link between A1298C polymorphism and pregnancy losses (Mtiraoui et al., 2006;Amira et al., 2008;Fatemeh et al., 2013; Farah et al., 2013). However, studies from Chinese, Egyptian and Iranian populations showed no significant association of A1298C polymorphism with RPL (Wang et al., 2004; Seremak et al., 2010; Settin et al., 2011; Yunlei et al., 2012; Amin et al., 2014).
When we investigated the joint effect of the two SNPs (Figures 2A and 2B), the wildtype CC of C677T and the mutant homozygote CC of A1298C, CC-CC frequency was extremely high among the patients compared to controls (20.5% vs. 9%) thus was contributing to nearly 3-fold elevated risk to develop the disease phenotype. This can be explained by the dominant effect of CC of A1298C polymorphism over CC of C677T polymorphism in genetic predisposition of RPL. On the other hand, the frequency of CT-AA is higher among controls than the patients suggesting the protective role of this combined genotype against RPL. In support of our results, Zetterberg et al., showed a strong protective role of CC-AA and CT-AA genotype combinations against RPLs (Zetterberg et al., 2002).
Studies conducted on the plasma levels by Lynn and Jesse reported that there is up to 70% reduction in enzyme activity in homozygous mutants of C677T variant, while only 35% reduction for heterozygotes compared to wild type. They further showed that the C677T variant was associated with elevated plasma homocysteine concentrations and interact with plasma folate, which was not observed in the case of A1298C polymorphism (Lynn and Jesse, 1999). It was suggested that activity of compound heterozygote (CT-AC) is as similar to that of the activity of TT homozygote of C677T polymorphism (Van der put et al., 1998). In addition, studies reported that individuals with heterozygous genotype (CT-AC) at both loci experience an intermediate loss of enzyme activity i.e. 40–50% (Muralidhara Rao et al., 2010). Though the present study did not have results on enzyme activity, the 4% increase in the frequency of CT-AC combination in patients compared to controls might be in support of above results. On the other hand, interesting observations were made when magnitude of disease was evaluated in relation to genotypes of the two SNPs. The CT genotype of C677T polymorphism exhibited a 4-fold (OR 3.87, 95% CI 1.15-12.9, p-value <0.05) increased risk for RPL women to experience >3 abortions which suggests an increase in the magnitude of pregnancy losses.
Though there is no significant risk association was found in the case of A1298C polymorphism, the frequency of mutant variant CC is raised to 54% among women with >3 pregnancy losses over women with less than 3 pregnancy losses. With regard to the magnitude of pregnancy losses, patients with CT-CC combination were significantly at higher risk for more than 3 pregnancy losses. Our observations were similar to the studies conducted by Saraswathy et al., who explained the selective disadvantage of presence of more than two mutant alleles in the fetal viability (Saraswathy et al., 2012).
As both the MTHFR polymorphisms are associated with reduced function and activity, the detrimental effect of mutations can be more pronounced in individuals with nutritional deficiency of folic acid and vitamin B12 and they may experience susceptibility to RPL. To resolve this contention, folic acid /homocysteine levels have to be measured in individuals who experiences RPL with mutant genotype which was the limitation of our study. Overall, it is not the solitary role of genetic polymorphisms in the establishment of the disease, gene and environmental interaction in the form of metabolic needs and dietary adequacy which is the main perpetrator in increasing the magnitude of RPLs.
Though there is literature exists establishing the association of these polymorphisms with the genetic predisposition to RPL, this is the first study in the direction of evaluating the data for magnitude of pregnancy loss particularly in low socio-economic group. The information acquired in the study is relevant to the better understanding and management of the condition. It is speculated that individuals carrying these polymorphisms with nutritional deficiency of folic acid and vitamin B12 may be at the higher risk for severe RPL as a result of gene and environmental interaction. To further validate, studies need to be focused on these lines in large sample size and by estimating the levels. In addition, an extended study in comparison with women belonging to high socio-economic status might present a clear idea on the potential role of gene and environmental factors (dietary) on RPL.
The authors have no conflicts of interest relevant to this article.
We thank the APCOST (AP State Council of Science and Technology), Hyderabad for providing financial assistance. We express gratitude to the blood donors for their co-operation in sharing their clinical data. We are grateful to the Modern Government Maternity Hospital, Petlaburj, Hyderabad, India and SVS Hospital, Mahbubnagar, India for giving us the opportunity to carry forward our research by providing blood samples.
Department of Genetics, Osmania University, Hyderabad, India
Amin K, Sharif K, Hossein K (2014) Association between the A1298C polymorphism of Methylenetetrahydrofolate reductase gene and recurrent spontaneous abortion. Iranian Journal of Neonatology 5: 7-11. http://dx.doi.org/10.22038/ijn.2014.2640
Amira SS, Ziyad M, Ali T, Ghazi Z, et al. (2008) High Prevalence of MTHFR Gene A1298C Polymorphism in Lebanon. Genetic Testing 12: 75-80. https://doi.org/10.1089/gte.2007.0064
Anil Kumar Sah, Nisha Shrestha, Pratikshya Joshi, Renu Lakha, et al. (2018) Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss. BMC Res Notes 11: 233. https://doi.org/10.1186/s13104-018-3321-x
Cande VA, Morgan RP, Celeste De M, Denise E, et al. (2007) Associations Between Two Polymorphisms in the Methylenetetrahydrofolate Reductase Gene and Placental Abruption. Am J Obstet Gynecol 197: 385.e1–385.e7. https://doi.org/10.1016/j.ajog.2007.06.046
Cyrus C, Padmalatha R, Chandra N, Gopinath PM, et al. (2009) MTHFR gene variants C677T, A1298C and association with Down syndrome: A case control study form South India. Indian J Hum Genet 15: 60-64. https://doi.org/10.4103/0971-6866.55217
Muralidhara Rao D, Anuraj N, Mukesh Y, Showmy KS (2010) Comparative modeling of methylentetrahydrofolate reductase (MTHFR) enzyme and its mutational assessment: in silico approach. International Journal of Bioinformatics Research 2: 5-9. https://doi.org/10.9735/0975-3087.2.1.5-9
Farah P, Moni T, Suraksha A (2013) Polymorphisms in MTHFR, MTHFD and PAI- 1 and recurrent miscarriages among North Indian women. Arch Gyneacol Obstetrics 288: 171-173. https://doi.org/10.1007/s00404-013-2877-x
Fatemeh E, Mohammad TA, Shohreh ZK (2013) Association of C677T and A1298C polymorphisms of the MTHFR gene with recurrent pregnancy loss. Pajoohandeh Journal 18: 167-173.
James AG, Stacey JB, Yong G, Yanhong Y (2011) Folic Acid Supplementation and Pregnancy: More Than Just Neural Tube Defect Prevention. Reviews in Obstetrics & Gynecology 4: 52-59.
Kluijtmans LA, Van den HLP, Boers GH, Frosst P, et al. (1996) Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolae reductase gene is a genetic risk for cardiovascular disease. Am J Hum Gen 58: 35-41.
Kobashi G, Emi HK, Mamoru M, Shigeki S, et al. (2005) MTHFR C677T Polymorphism and factor V Leiden mutation are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese women. Semin Thromb Hemost 31: 266-271.
Lynn BB and Jesse FG (1999) Polymorphisms of Methylenetetrahydrofolate Reductase and Other Enzymes: Metabolic Significance, Risks and Impact on Folate Requirement. Recent Advances in Nutritional Science 129: 919-922. https://doi.org/10.1093/jn/129.5.919
Mohamed AE, Hanaa MA, Sherin M Abd E, Mohammad A (2014) MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder. BioMed Research International 2014: 1-9. https://doi.org/10.1155/2014/318483
Mtiraoui N, Zammiti W, Ghazouani L, Jmili BN, et al. (2006) Methylene tetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses. Reproduction 131: 395-401. https://doi.org/10.1530/rep.1.00815
Nair RR, Khanna A, Singh R, Singh K (2013) Association of maternal and fetal MTHFR A1298C polymorphism with the risk of pregnancy loss: a study of an Indian population and a meta-analysis. FertilSteril 99: 1311- 1318. https://doi.org/10.1016/j.fertnstert.2012.12.027
Quere I, Bellet H, Hoffet M, Janbon C, et al. (1998) A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages. Fertility and Sterility 69: 152-154. https://doi.org/10.1016/s0015-0282 (97)00451-2
Ramadevi AR, Govindaiah V, Ramakrishna G, Naushad SM (2004) Prevalence of Methylene tetrahydrofolate reductase polymorphism in South Indian population. Curr Sci 86: 440-443.
Ren A and Wang J (2006) Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis. FertilSteril 86: 1716-1722. https://doi.org/10.1016/j.fertnstert.2006.05.052
Saraswathy KN, Mohammad A, Ratika S, Benrithung M, et al. (2012) Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India. Mol Biol Rep 39: 5025-5031. https://doi.org/10.1007/s11033-011-1299-8
Seo WB,and Sang SL (2009) The factors affecting pregnancy outcomes in the second trimester pregnant women. Nutrition Research and Practice 3: 134-140. https://doi.org/10.4162/nrp.2009.3.2.134
Seerat S, Saraswathy KN, Mahima G, Shweta K, et al. (2012) MTHFR C677T Polymorphism Among Three Mendelian Populations: A Study from North India. Biochem Genet 50: 893-897. https://doi.org/10.1007/s10528-012-9529-x
Seremak MA, Drews K, Kurzawinska G, Bogacz A, et al. (2010) The significance of 1793G>A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett 3: 717-723.
Settin A, Elshazli R, Salama A, ElBaz R (2011) Methylenetetrahydrofolate reductase gene polymorphisms in Egyptian women with unexplained recurrent pregnancy loss. Genet Test Mol Biomarkers 15: 887-892. https://doi.org/10.1089/gtmb.2011.0049
Shiny V, Dayanand CD, Pushpa FK, Moideen KA, et al. (2015) Evidence of paternal N5, N10 - Methylenetetrahydrofolate Reductase (MTHFR) C677T gene polymorphism in couples with recurrent Spontaneous Abortions (RSAs) in Kolar District- A South West of India. Journal of Clinical and Diagnostic Research 9: BC15-BC18. https://doi.org/10.7860/jcdr/2015/10856.5579
Singh T, Sharma S, Nagesh S (2017) Socio-economic status scales updated for 2017. Int J Res Med Sci 5: 3264-3267. https://doi.org/10.18203/2320-6012.ijrms20173029
Speroff L, Glass RH, Kase NG (1999) Clinical Gynaecologic Endocrinology and Infertility. 6th ed. Baltimore: Lippincott Williams & Wilkins: 1-1200.
Steegers TRP, Boers GH, Blom HJ, Trijbels FJ, et al. (1992) Hyperhomocysteinemia and recurrent spontaneous abortion or abruptio placentae. Lancet 339: 1122-1123. https://doi.org/10.1016/0140-6736 (92)90725-i
Theresa OS and William G J (2000) Folic acid: influence on the outcome of pregnancy. The American journal of Clinical Nutrition 71: 1295S-303S. https://doi.org/10.1093/ajcn/71.5.1295s
Tippisetty S, Ishaq M, Komaravalli PL, Jahan P (2011) Angiotensin converting enzyme (ACE) gene polymorphism in vitiligo: protective and predisposing effects of genotypes in disease susceptibility and progression. Eur J Dermatomal 21:173-177.
Vandana Rai (2016) Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis. Ind J Clin Biochem 31: 402-413. https://doi.org/10.1007/s12291-016-0554-0
Van der Put NM and Blom HJ (2000) Reply to Donnelly. Am J Hum Genet 66: 744-775. https://doi.org/10.1086/302788
Van der put NM, Gabreels F, Stevans EM, Smeitnik JA, et al. (1998) A second mutation in the Methylenetetrahydrofolate reductase gene: an additional risk factor for neural- tube defects?. Am J Hum Genet 62: 1044-1051. https://doi.org/10.1086/301825
Wael A, Imad AA, Marwan A (2016) The association of hyperhomocysteinemia with recurrent pregnancy loss 1-8.
Wang XP, Lin QD, Ma ZW, Zhao AM (2004) C677T and A1298C mutation of the methylenetetrahydrofolate reductase gene in unexplained recurrent spontaneous abortion. Chin J Obstet Gynaecol 39: 238-241.
Wu X, Lanjun Z, Hui Z, Dajian H, et al. (2012) Association between the MTHFR C677T Polymorphism and Recurrent Pregnancy Loss: A Meta-Analysis. Genetic Testing and Molecular Biomarkers 16: 806-811. https://doi.org/10.1089/gtmb.2011.0318
Yunlei C, Jianhua X, Zhaofeng Z, Xianliang H, et al. (2012) Association study between methylenetetrahydrofolate reductase polymorphisms and unexplained recurrent pregnancy loss: A meta-analysis. Gene 514: 105-111. https://doi.org/10.1016/j.gene.2012.10.091
Zetterberg H, Regland B, Palmer M, Ricksten A, et al. (2002) Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos. European Journal of Human Genetics 10: 113-118. https://doi.org/10.1038/sj.ejhg.5200767
Methylene tetrahydrofolate reductase (MTHFR); Recurrent pregnancy loss; Polymorphisms; Magnitude; Low socio-economic status |
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Home > What we say > Press and media > Latest press releases > Return of page 3 ‘disappointing’ – Girlguiding Scotland
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Return of page 3 ‘disappointing’ – Girlguiding Scotland
Girlguiding Scotland is very disappointed by the news today (Thursday 22 January 2015) that The Sun has shown a topless model on page 3.
Girlguiding Scotland’s Chief Executive Denise Spence said:
“We believe that all girls have the right to live in a fair and equal society where women’s achievements are more important than what they look like.
“We – and generations of girls and women – are disappointed that The Sun continues to send the message that if you’re female, you’re a decorative object above all else.”
Girlguiding Scotland members have been actively involved in campaigning against Page 3 as part of Girlguiding’s Advocate programme of young campaigners.
Girlguiding Scotland is Scotland’s leading charity for girls and young women with more than 60,000 members. We are part of a worldwide movement which enables girls and young women to fulfil their potential and take an active and responsible role in society. Girlguiding opens up a world of exciting opportunities for girls and young women across Scotland. Girls can take part in a wide range of activities from adventure sports to camps, international trips, science projects and community action. Find out more @GirlguidingScot,www.facebook.com/GirlguidingScot or www.girlguidingscotland.org.uk.
Find all the latest news from Girlguiding Scotland members, volunteers and supporters here.
Resources for making guiding happen in your area
Rainbows (age 5-7)
Brownies (age 7-10)
Guides (age 10-14)
Rangers (age 14-18)
© The Guide Association Scotland known as Girlguiding Scotland is a registered Scottish charity No. SC005548
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Publication - Statistics
Criminal proceedings in Scotland 2016-17: statistics
Directorate:
Justice Directorate
Law and order, Statistics
Statistics on criminal proceedings concluded in Scottish courts and alternatives to prosecution, issued by the police and by the Crown Office.
101 page PDF
Accessibility: This document may not be fully accessible.
This publication is available to download in other formats. More…
Criminal Proceedings in Scotland, 2016-17 (XLSX 270.6 kB )
Annex E - Legislative and policy changes
Criminal Proceedings in Scotland, 2016-17
1. Trends in people proceeded against and convicted
2. Trends in conviction rates
3. Acquittals by crime type
4. People convicted by court type
5. People convicted by crime/ offence
6. People convicted by crime group
7. People convicted by offence group
8. Headlines in court sentencing
9. Custodial Sentences
10. Custodial Sentences by type of crime
11. Community Sentences
12. Financial penalties and other sentences
13. Aggravators
14. Age and Gender
15. Police Disposals
16. Crown Office and Procurator Fiscal Service Disposals
17. Bail and undertakings
Table 1 Summary of known action in the Scottish Criminal Justice System, 2007-08 to 2016-17
Table 2(a) People proceeded against in court by main crime/offence and outcome of court proceedings, 2016-17[1]
Table 2(b) People proceeded against in court by main crime/offence and percentage outcome of court proceedings, 2016-17[1]
Table 3 People convicted by type of court, 2007-08 to 2016-17
Table 4(a) People proceeded against by main crime/offence, 2007-08 to 2016-17
Table 4(b) People convicted by main crime/offence, 2007-08 to 2016-17
Table 4(c) Conviction rate[1] by main crime/offence, 2007-08 to 2016-17
Table 5 Numbers of people convicted per 1,000 population by sex and age, 2007-08 to 2016-17
Table 6(a) Males[1] convicted by main crime/offence and age, 2016-17
Table 6(b) Females[1] convicted by main crime/offence and age, 2016-17
Table 7(a) People convicted by main penalty, 2007-08 to 2016-17
Table 7(b) Percentage of people convicted by main penalty, 2007-08 to 2016-17
Table 8(a) People convicted by main crime/offence and main penalty, 2016-17
Table 8(b) People convicted by main crime/offence and main penalty, 2016-17
Table 8(c) People convicted by gender, main crime/offence and main penalty, 2016-17
Table 9 Percentage of people convicted receiving custodial sentences by main crime/offence, 2007-08 to 2016-17
Table 10(a) People receiving a custodial sentence by main crime/offence and length of sentence, 2016-17[1]
Table 10(b) People receiving a custodial sentence by gender, main crime/offence and length of sentence, 2016-17[1]
Table 10(c) Average length of custodial sentence in days, by main crime/offence, 2007-08 to 2016-17[1],[2]
Table 10(d) People receiving a custodial sentence by length of sentence, 2007-08 to 2016-17
Table 11 People convicted by main penalty, gender and age, 2007-08 to 2016-17
Table 12 People convicted with an aggravator recorded against the main charge by gender, 2007-08 to 2016-17 [1],[2]
Table 13 People convicted with an aggravator recorded against the main charge by crime type, 2016-17[1]
Table 14 Bail orders made by main charge, 2007-08 to 2016-17[1]
Table 15 Bail-related Offences[1] with a conviction, 2007-08 to 2016-17
Table 16 Undertakings to appear in court, by gender and age, 2009-10 - 2016-17[1],[2]
Table 17 People given police disposals by disposal type, 2008-09 to 2016-17
Table 18 People given ASBFPNs, by main crime/offence and age and gender, 2016-17[1]
Table 19 People given COPFS disposals by disposal type, 2008-09 to 2016-17
Table 20 Males given fiscal fines, by main crime/offence and age, 2016-17[1]
Table 21 Females given fiscal fines, by main crime/offence and age, 2016-17[1]
Table 22 Fiscal fixed penalties by main crime/offence and age and gender, 2016-17[1]
Annex A - Data Sources and Data Standards
Annex B - Data Quality, Data Processing and Data confidentiality
Annex C - Understanding the statistics in this bulletin
Annex D - Definitions, Classifications and Notation
A National Statistics publication for Scotland
E.1 There were no major legislative changes in 2016-17 but it may be useful for users to be aware of the following changes in more recent years:
E.2 On December 5th 2014 the alcohol limit for drivers in Scotland was reduced from 80 mg to 50 mg per 100 ml blood.
E.3 Aside from the changes in drink driving legislation there have been no other major legislative changes throughout 2016-17 which impact on the comparability of the statistics. However, it should be noted that legislation introduced in more recent years prior to 2016-17 will continue to have an impact on the statistics as people are charged under the new legislation and proceeded against in court. Some of these changes are outlined below.
E.4 The Offensive Behaviour at Football and Threatening Communications (Scotland) Act 2012 was implemented on 1 March 2012. The Act criminalises behaviour which is threatening, hateful or otherwise offensive at a regulated football match including offensive singing or chanting. It also criminalises the communication of threats of serious violence and threats intended to incite religious hatred, whether sent through the post or posted on the internet.
E.5 On 6 October 2010, section 38 of the Criminal Justice and Licensing (Scotland) Act 2010 was implemented. This introduced a new offence to combat threatening or abusive behaviour. Unlike the common law offence of breach of the peace, where it is necessary to show a "public element" to the conduct, there is no requirement in the new offence to demonstrate that the offending behaviour was in a public place.
E.6 Section 39 of the same act also introduced a specific criminal offence of stalking. It is based fairly closely on the offence of harassment in the Protection from Harassment Act 1997, although with important differences. Section 39 of the Act defines conduct which amounts to stalking by means of a list of behaviours. This includes following or attempting to contact the victim; monitoring electronic communications; watching and spying. It also includes a "catch all" "acting in any other way that a reasonable person would expect would cause (the victim) to suffer fear or alarm".
E.7 Section 17 of the same act included a presumption against short sentences (3 months or less). This presumption states that a court must not pass a sentence of imprisonment for a term of 3 months or less on a person unless the court considers that no other method of dealing with the person is appropriate.
E.8 The Sexual Offences (Scotland) Act 2009 was implemented on 1 December 2010. The act replaces a number of common law crimes such as rape, lewd and libidinous practices and sodomy, with new statutory sexual offences. The act also created a number of new 'protective' offences which criminalise sexual activity with children and mentally disordered people. Protective offences are placed into categories concerning young children (under 13) and older children (13-15 years).
E.9 The new legislation only applies to offences committed on or after 1 December 2010, with any offences committed prior to this date recorded using the previous legislation. The new legislation may result in some increases in Group 2 crime (sexual crimes), though the more noticeable effect was a change in the distribution of these crimes among the sub classifications. For example, some crimes previously categorised as lewd and libidinous practices are now classified as sexual assault. The crime categories within the 'sexual crimes' grouping have been updated to reflect the current legislative position.
Summary Justice Reform
E.10 Summary justice ( i.e. non-jury) reform focused on reducing the number of cases that go to court needlessly with more people being dealt with by non-court actions, where it is appropriate to do so. 2008-09 was the first full year across which many aspects of the reform were implemented.
E.11 A range of measures were implemented as part of the Anti-Social Behaviour (Scotland) Act 2004 and the Criminal Proceedings etc. (Reform) (Scotland) Act 2007, including:
Increased roll out and use of alternatives to prosecution that can be offered by the police ( e.g. Anti-Social Behaviour Fixed Penalty Notices and Formal Adult Warnings) and procurator fiscal ( e.g. increased use of Fiscal Fines)
Reforms to bail procedures
Increased use of undertakings
Increased sentencing powers in Summary courts
Enhanced fines enforcement
Replacement of district courts with Justice of the Peace ( JP) courts
Reforms to appointing and training lay Justices of the Peace ( JPs)
Reforms to summary criminal legal aid
Ian Volante
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See Defense Contracts Won
Defense Contract Totals in 2018 Count:3,805,028 Dollar Amount:$358,285,486,667
Home | Contractor Search | Data Downloads | About Data Updated Through 2018
Lodging - Hotel/Motel
2008 Government Contracts
Product/Service Information
Download the entire list of Defense Contracts for this product/service from 2000 - 2018
Product/Service Lodging - Hotel/Motel
Dollar Amount of Defense Contracts Awarded for this Product/Service from 2000 to 2018 $2,616,231,098
Number of Defense Contracts Awarded for this Product/Service from 2000 to 2018 50,183
Govt Contracts (Defense) - Count/$ Dollar Amount
2018 2,313/$196,779,764
2015 1,891/$81,279,669
2002 916/$108,605,011
2001 418/$53,588,186
Defense Contract List
for the Year 2008
for this Product/Service (* Contract Dollar Amounts and Defense Dept Contract IDs are available with data download)
Contract Dollar Amount *
Defense Dept Contract IDs/Numbers *
Government Contractor Name & Address HAWTHORNE INN AND SUITES
6789 BOEING DR
EL PASO , TX 79925
Government Contracting Office PU W6BB ACA BLISS Principal Place of Performance El Paso, Texas
(El Paso County)
Claimant Program ALL OTHER SUPPLIES AND EQUIPMENT
Weapon System NOT DISCERNABLE
From Date 5/9/2008 To Date 5/9/2008
Government Contracting Office XR W3Q2 ATEC MISSION SUPT CONT A Principal Place of Performance El Paso Internationa, Texas
Claimant Program SERVICES
From Date 12/3/2007 To Date 12/3/2007
Government Contractor Name & Address DISCOVERY GROUP, INCORPORATED, THE
9119 KATY FWY
Government Contracting Office SUPSHIP BATH Principal Place of Performance Mobile, Alabama
(Mobile County)
From Date 9/25/2008 To Date 9/25/2008
(* Contract Dollar Amounts and Defense Dept Contract IDs are
available with data download)
Page: 1 ... 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 1101 1102 1103 1104 1105 1106 1107 1108 1109 1110 1111 1112 1113 1114 1115 1116 1117 1118 1119 1120 1121 1122 1123 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 1136 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 1171 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189
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Watch Your Health will empower Bharti Assist Global to assess, amend and monitor the health of the corporates in India by providing them with holistic online and offline wellness services.
Bharti Assist Global is a flagship company of Bharti Group. The company is known for its ability to provide custom-made, value-added products and solutions pertaining to medical assistance, travel assistance, roadside assistance, warranty assistance, corporate mobility, mobile protection and wallet protection.
The association with Watch Your Health will enable Bharti Assist Global to leverage the corporate wellness market, which is a niche market & largely been unexplored.
Watch Your Health’s technology-based innovation proposition makes use of compelling insights using complex data analytics. Constant inflow of data recorded with the help of intelligent algorithms leads to implementation of customized wellness solutions.
“The insuretech ecosystem in India is growing at a phenomenal pace providing massive opportunities for new age players” stated Ratheesh Nair, Founder and CEO, Watch Your Health.Com India Pvt. Ltd., in a press release.
“Corporates are undertaking various initiatives towards enhancing the health and wellness quotient of their employees resulting in a 10 percent rise in corporate wellness engagement.
With our tie up with Bharti Assist Global, we aim to advocate good health as a culture and bring down claims among the corporates by offering wellness solution to employees at the press of a button.” he added.
Neeraj Verma, Head-Bharti Assist Global said, “We at Bharti Assist believe that health is the first and foremost wealth. However, in a bid to excel in the age of cut-throat competition, corporate employees lead a stressful life and neglect their health and wellness. We aim to bring about a change in the perspective of employees with the help of continuous engagement through monitoring and preventive healthcare. The program is designed in such a way that the customers can easily and effectively work on improving their health and lifestyle, eventually profiting from it.’
Genome assembly of Indian cobra may be a step towards humanised anti-venom
Indian scientists have assembled the genome sequence of the poisonous Indian Cobra paving way for researchers to synthesise cost-effective and safe humanised anti-venom.
Serum’s pneumococcal vaccine receives WHO prequalification
The low-cost pneumococcal vaccine developed by Serum Institute of India, Pune named Pneumocil has recently been prequalified by the World Health Organisation against pneumococcal infections in children.
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Haida Gwaii Visitors Guide
‘Assemble your own meal’ kits grow into $120M industry in Canada
Kits offer a middle ground between eating out and grocery shopping
Matthew Richardson decided it was finally time to change his cooking habits.
After moving in with his girlfriend this past summer, Richardson, 36, figured they should put a stop to their frequent eating out and make a real effort to prepare their own meals at home.
But he didn’t know where to start. Elaborate recipes felt intimidating and he had no clue where to look for easy, healthy food that would appeal to both of their tastes.
“She’s a vegetarian, I am not a vegetarian,” says Richardson, who lives in Saint John, N.B.
“I was looking for ways to learn some recipes, and figure out how to prepare things I don’t know how to prepare.”
READ: Protecting B.C.’s food sources
So he turned to home-delivered meal kits, a phenomenon that has quickly grown into a $120-million industry in Canada, according to the market research company NPD Group.
Meal-kit companies offer consumers a menu of ready-to-prepare dishes that are typically marketed as easy to make, healthy and delicious. Meal ingredients arrive pre-portioned with a recipe for consumers to follow.
The meal-kit industry started in Sweden, according to Robert Carter of NPD Group, and has spread globally over the last five years. The industry has roughly doubled in Canada since 2014, Carter added.
“It’s grown fairly aggressively in the U.S. marketplace, and kind of filtered here into Canada,” he said, adding that meal kits are ”now one of the fastest-growing food segments in the Canadian marketplace.”
On a friend’s recommendation, Richardson first signed up for Goodfood, a meal-kit company founded in Montreal in 2015. The largest family-sized meal-kit boxes start at $8.75 per person per meal and recent options have included whisky rubbed pork chop with scalloped potatoes, red lentil stew with sweet potatoes, and acorn squash tacos.
One of Richardson’s favourite meals — quinoa-stuffed peppers — arrived boxed with portions of poblano peppers, corn, spinach, cilantro, quinoa, cheese, tomatoes, an onion, panko crumbs and a spice blend. It took Richardson and his girlfriend about 45 minutes to make.
For Jayne Zhou, an HR co-ordinator in Vancouver who’s been on maternity leave since early in the year, meal kits have made life a little simpler.
She says it initially took some trial and error to figure out how much food to order for her family of four. She started getting weekly meals delivered but found some food would get wasted if her family met up with friends or went out to dinner.
They now order meals for two people every other week. Zhou says she loves that as a self-described ”newbie cook” she’s built confidence in the kitchen.
“We had ginger pork meatballs and I was like: ‘That wasn’t too hard, maybe I’ll be able to make this recipe again,’” she says.
Richardson also believes his kitchen chops have improved. In the fall, a few months into his flirtation with meal kits, he visited his family’s farm in Nova Scotia and decided to pick some chanterelle mushrooms to make a risotto.
“A year ago, I wouldn’t even consider making a risotto,” he says. “It would seem like this huge, intimidating task that I would never tackle. It definitely gave me more confidence, to go out and try dishes that I normally would be like, ‘That’s something that somebody who’s a professional would make.’”
READ: Who donates 10-year-old food?
Both Zhou and Richardson say meal kits have been a cheaper alternative than ordering in or going to a restaurant but they’ve definitely been more expensive than doing their own grocery shopping.
Graham McDonnell, a stylist from Dartmouth, N.S., was lured by the convenience of having meal kits delivered to his door but has gone back to doing his own grocery shopping.
He and his partner used to shop for groceries often but would end up throwing away a lot of food since they didn’t plan properly. Now they’ve refocused their energy on meal planning.
“If you take the time to plan your meals and not over-shop … you can kind of organize (a meal-kit type experience) yourself, basically,” McDonnell says.
While meal-kit companies often market their food using buzzwords like “farm-fresh,” “sustainable,” and “antibiotic- and hormone-free,” one nutritionist says it’s too early to assess the health benefits of buying into a meal plan given few real studies have been done on the subject. But University of Guelph Prof. Jess Haines does see the appeal of the service, particularly for people who work long hours or don’t have a lot of time to think about shopping for food. And some of the meal kits she’s seen “appear to have very healthful options,” Haines says.
After about three months of using Goodfood, Richardson and his girlfriend decided to try some of the competition. Richardson heard others swear by Toronto-based Chefs Plate but personally found the ingredients to be a little less fresh than what he was used to. He liked German company HelloFresh but found the vegetarian options lacking.
The couple continues to try meal kits from new companies looking to cash in on the trend, especially since social media ads targeted to them are often offering a few free meals.
“Apparently I’m looking at these things enough that the advertisers know that that’s what I’m into,” he says.
FortisBC to lower natural gas rates in 2018
Millennials closing in as B.C.’s biggest wine drinkers
Telus to take charge of TV and internet on Haida Gwaii following acquisition of Gwaii Communications
Haida Gwaii telecommunications service provider begins transition to new ownership following sale
Commercial fishing concerns over marine protected areas
Fishermen of the Northern Shelf Bioregion seek solutions through consultations
Haida Gwaii libraries announce their most popular books from the past year
These titles had islanders booking it to the library in 2019
Explore Haida Gwaii Observer
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Sustainable Architect Ignites Innovation In Cleveland's Underserved Areas
By Brian Spaen
Underserved neighborhoods are something we too often ignore. For one architect from California, his mission is to take these struggling communities head-on and to try to boost them into their full potential.
Erick Rodriguez works for Burten, Bell, Carr Development and the mission statement on their website is to "empower citizens and revitalize blighted and underserved communities.” He’s also involved with the Detroit Shoreway Community Development Organization, or DSCDO. A typical day for him includes tackling various projects that are economy-friendly in the Cleveland area. One of the neighborhoods he deals with is Kinsman, a poverty-riddled section of the city.
Over 73 percent of families that live in Kinsman are living below the poverty line. A quarter of those people are seniors past the retirement age. Only 6.1 percent of the population has anything beyond a high school diploma. Over half the population are living in housing they can’t afford, and that’s even higher for those that rent. They’re also collecting food stamps; the median household income is just $16,628 -- nearly $10,000 less than the Cleveland average.
A project Rodriguez has worked on in the Kinsman area is called “BoxSpot.” This has the focus of placing local organizations in a building made out of recycled products. The building is made from 10 shipping containers stacked together, fused with a contemporary design, and it will be planted in a vacant half-acre lot. The goal is to create a place for local businesses to operate under low costs. After much planning, Cleveland approved the project back on April 21st and the goal is to get it done within the next year.
That isn’t all Rodriguez has given to the neighborhood. He was the man behind a teaching kitchen, CornUCopia Place. Eric Wells, a culinary instructor, grew up in the area and hosted a series of cooking classes last year. He’s also done workshops himself under the Cleveland Urban Development Center, teaching others about how to think more sustainably and about affordability when it comes to designing.
Thanks to all who came to the #citizenstinyhouse Open House last night! Lots of great people and conversations! pic.twitter.com/GpvHoD2dgY
— Tiny House Cleveland (@tinyhousecle) August 9, 2016
As for the DSCDO, he’s worked on another project alongside them, expanding the Cleveland EcoVillage. He’s been part of the process of creating the first two tiny houses that opened up last summer. These are miniaturized homes that are close to 600 square feet, similar to a smaller one-bedroom apartment. Thanks to elevated ceilings, these houses are bigger than expected with pull-out couches, combination washer/dryers, and plenty of hidden away storage space. Both houses were available to rent until placed on the market last September.
These buildings are alongside other great places to live in the EcoVillage. For those that don’t want to live in condensed areas, there are spacious townhomes that save plenty on utilities each year. It’s also the home of the Green Cottage, a building from 2007 that was awarded the first LEED Platinum award in the city of Cleveland. The recession many years ago put a halt to more being being built.
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Home > Articles > Junk Food Giant PepsiCo Buying Expert Opinion, Health and Nutrition Experts Selling Out to Highest Bidder
Junk Food Giant PepsiCo Buying Expert Opinion, Health and Nutrition Experts Selling Out to Highest Bidder
5 Aug 2010 Stephen @DesignWise
Pepsi’s strategy: Create a research environment so scientists and public health experts don’t feel out of place at the corporate HQ of sugar, salt and fat.
Last month PepsiCo set off a firestorm among angry bloggers when the company attempted to buy its way onto the popular ScienceBlogs (run by Seed Media Group) with its own offering called Food Frontiers. Apparently, the actual scientists didn’t appreciate having their space invaded by PR flaks.
One blogger put it succinctly, “I don’t care how many PhD scientists they hire, PepsiCo is a corporation, not a research institute, for crissakes!” Within two days, ScienceBlogs apologized and pulled PepsiCo’s plug, but not before some disgusted bloggers quit altogether. (Food Frontiers continues to live on PepsiCo’s corporate Web site.)
While this story illustrates a victory in the battle against one corporation’s attempt to control scientific discourse, in the bigger picture, PepsiCo appears to be winning the war.
PepsiCo Picks off Public Health Experts One by One
Ask anyone who’s been in the public health field for at least 10 years if they’ve heard of Derek Yach, and the response is likely to be: “Of course, he’s a public health hero.” If you ask for a response to Yach’s decision to go work for PepsiCo, the reaction will be head-shaking. “Shocked,” “deeply disappointed,” “a blow to public health,” were all phrases I heard when the news came, in 2007, that one of the world’s most respected public health experts went over to the dark side.
Derek Yach’s story even plays a prominent part in a graduate-level food policy class at NYU that dedicates an entire class session to industry co-optation, because of its current impact on the nation’s debate over the obesity epidemic.
It was a personnel coup for the nation’s largest food company and purveyor of such notoriously unhealthy products as Mountain Dew and Cheetos. PepsiCo’s new “director of global health policy” came with a pedigree the company must have been salivating over.
You can read the rest of this article, originally published at AlterNet…
How Junk Food Giant PepsiCo Is Buying Up High-Ranking Experts to Look Like a Leader in Health and Nutrition
ArticlesDerek Yach, Food Frontiers, Pepsi
Unmasking Aspartame… Aliases include NutraSweet, Canderel and now AminoSweet
Protecting US from Hardened Criminals and Their aCowmplices…
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Linda Vista Community Hospital
You are here Home > Historical Buildings > Linda Vista Community Hospital
Seen on the TV show Ghost Adventures, the historic hospital is said to be haunted by many patients who died traumatically here. The site has been used as a setting for a great number of films including Outbreak, To Live and Die in L.A., and Day of the Dead 2: Contagium, as well as for many TV shows and music videos.
610-30 St. Louis Street
34.038164, -118.21722699999998
Los Angeles County, California
Boyle Heights, CA (0.7 mi.)
Los Angeles, CA (1.8 mi.)
Vernon, CA (2.5 mi.)
Belvedere, CA (2.8 mi.)
East Los Angeles, CA (2.8 mi.)
Huntington Park, CA (3.9 mi.)
Maywood, CA (4.0 mi.)
Commerce, CA (4.2 mi.)
Bell, CA (4.5 mi.)
Walnut Park, CA (4.9 mi.)
Sara Harris | January 30, 2014 at 10:17 am
I would love to investigate this place. It’s amazing
john | August 12, 2017 at 10:30 pm
sara send me a message agentssg13@gmail.com
Robert | July 25, 2014 at 8:59 pm
I wood like to investigate who do I call .
My team is ready
M.M | August 4, 2014 at 9:44 pm
Sara Harris, and Robert:
The hospital is now closed and has not been doing anyone tours. It is under construction to be turned into a retirement home
Amber Alward | October 4, 2015 at 6:29 pm
I heard it was torn down
Anonymous | October 31, 2014 at 1:32 pm
Just seems so wrong to convert this into a retirement home…
Jessica Nazareth | April 6, 2016 at 10:11 am
I very much agree with this. it needs to be turned into a good true Jesus with Jesus Holy Spirit church.
or tear this whole place down because it has too many evil demons at this place.
Long time resident | November 28, 2015 at 10:11 pm
I lived in the area for a while and always drove by. The building would have dim lights on & it was abandoned. Once I was driving by with my daughter and transport van had a man in it, he looked right at us. It turned in there so I turned in too follow since I knew it was abandoned. At that split second that van disappeared. I drove all around the build and nothing. I said to my daughter you seen that shit didn’t you!?!
Arnav | January 14, 2016 at 1:27 am
For the investigation part, I would refer to the article -http://www.hauntedplacesincalifornia.com/2016/01/linda-vista-community-hospital-scary-history-ghost-investigations.html . Three ghosts are said to haunt this particular spot. The spirit of two girls and a man in his thirties are said to wander at this construction. We have underwent many investigations that proved out to be a productive one. However this place is now closed and does not entertain any further researches.
they are demons pretending to be those ghosts/spirits.
Mingan | April 4, 2017 at 8:42 am
you know how?
Iceman0666 | March 1, 2016 at 4:40 pm
Wack is this shit not there anymore? Im so down to sneak in..can u still sneak in, in any part of the building..lets go, i’ll lead n expedition to any local abandon spots that are haunted
Ashap83 | March 6, 2016 at 11:59 am
I was on a film shoot a few years back and after spending the day there I can definitely say this place is haunted. From seeing shadow figures in the windows, to all the fully charged battery operated gear losing all power in seconds, cold spots through out, things being thrown at myself and my crew, and finally very creepy voices heard on the walky talkies at the end of the shoot when all walkers where untouched and laying on a table.
jannett | October 11, 2016 at 7:44 pm
this place is now turned into apts for the elderly
bernie | October 14, 2016 at 4:42 pm
I have been here at this site. we have a little girl in the upstairs ball room. on infrared cameras we have her, on regular film nothing. these pictures were shot at the same time same location. also the fourth floor is were we had shadow people, footsteps, evps and heard voices with the naked ear. in the o.r. room we had our first sense of being touch, spider web feel. yes this place also has evil spirits too, some nights we had nothing other nights hits left and right.
billy vortex | September 11, 2017 at 12:54 am
I was the talent coordinator on Evilution…and I experienced a couple things…..i was with the make up and wardrobe girl talking in the back parking lot about 40 ft from any car or 100ft from any building….so were talking and smoking and in the corner of our eyes a shaggy dog walked up to us….we all stopped to great the dog at our feet and it disappeared…gone if it walked away or passed us we would of seen it….but nope GONE. Then in the old nun building I was at the back door walking in and at the end of the hallway a nun in a full nun outfit floated across the hallway and disappeared..
Karl | June 4, 2018 at 9:05 pm
This place is haunted. I worked on a film and we were one of the last productions to work in Linda Vista. It was September of 2012.
The funny part is people on the crew were swearing this place is haunted and I was like, Pffh!
One crew member claimed that in another production she had photos of orbs in the basement.
And another guy who had worked on A Nightmare On Elm Street (the one that was filmed there, obviously) said there was a scene where a woman puts her hand in a container full of needles. Of course, the needles were plastic. But when she pulled her hand out there was a legit metal needle stuck to her hand.
That was weird to hear. But my experience…
The place was AMAZING. I like weird places and this place had it. From the huge mental hospital sign to the hospital records still stacked in random rooms to the creepy dentist chair in the basement.
There’s one floor that was supposedly the most haunted. Unfortunately, that was the one floor that was locked.
We filmed there for one day. I ventured off alone and put a “hot brick” (a walkie battery) in the stairway door of each floor I went on – just to make certain I wouldn’t lock myself in.
I spent maybe 20 minutes on all the floors – mainly hurrying through – being alone it was weird. Room after room of empty rooms and knowing they were once full of patients.
So after returning to the ground floor I noticed what looked like rust on my hand – I tried rubbing it off and it didn’t budge. It appeared I had black and blue marks and no joke – it was where fingers would have been had someone held my hand.
I took a photo of my hand (with my phone – I still have the photo saved on my computer) and the bruising didn’t show in the photo. I always wondered if someone with editing software could somehow get the bruises to show. They took a few days to fade.
The funny thing is the main actress (who a lot of the crew disliked) walked by when I was taking a photo of my hand and she says to me, almost disgusted, “Why are you taking a picture of your hand?!” I told noone for a few years. I was in denial.
I get chills thinking about it. I wonder whom it was holding my hand.
Godina | October 9, 2018 at 12:43 pm
Who would be down to come with me on Halloween and investigate?
Kim | November 5, 2018 at 6:55 pm
I had a bad feeling when I saw the building from the street passing by in the car. The feeling feels like when someone is watching you in a scary way.
Sarah Tipton | November 5, 2019 at 11:14 pm
The Linda Vista Hospital was first established in 1904 as the Santa Fe Coastlines Hospital, a prospering healthcare facility dedicated to servicing employees of the Santa Fe Railroad. During the early decades of the 20th century, the hospital flourished as did Los Angeles’ surrounding Boyle Heights neighborhood. Last i heard it was planned to be made into a senior complex. oh god as if the place is infected with the dead already. i say clear out the ghosts first then bless it then build
By the late 1970s, the railroad hospital association facilities were experiencing declining use, as more railroad workers began to use conventional medical-insurance policies. The area surrounding the hospital also became a less-affluent area and hospital funding was affected. The Santa Fe Railroad sold the 150-bed hospital to a managed healthcare company in 1980. According to a California Health Law News report, when Linda Vista tried to reduce operational expenses in response, the hospital was blamed for an increase in facility death rates. During that time, the hospital was regularly treating a fair number of gunshot wounds and stabbings from the local neighborhoods, which affected its mortality statistics. An increase in uninsured and under-insured patients forced the hospital to close its emergency services department in 1989. The quality of care at Linda Vista Community Hospital continued to decline as doctors moved to other hospitals. In 1991, the hospital ceased operations
In 2011, the 4.2-acre Linda Vista Hospital complex was purchased by AMCAL Multi-Housing Inc. The structures on the historic registry, the main hospital and former nurses dormitory, were renovated into the Linda Vista Senior Apartments and now provide a total of 97 apartments for fixed-income seniors plus a medical facility.
before the place became apartments… she is watching
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When love gives you wings, don't be afraid to fly
By Naila FrancisStaff Writer
At some point this year, my boyfriend Zane may take off for Italy or Spain, Turkey or Argentina.
He may go for two weeks or two months, or maybe even six � and all without me.
And, yes, as madcap and risky as it may seem, I�ve signed off on the plan, championed it from the very first even, while imagining, with bittersweet joy, the grand adventure he�d have.
I know: throwing my support behind such a journey does not sound like a decision someone in a loving, committed relationship would make. It�s in fact more likely I�ve waded too deep into the crazy pool or taken to courting disaster. At least, these are the assessments I imagine others will make. Some may even wonder if this is perhaps my own sneaky attempt at leave-taking or a bid, drastic and ill-conceived, to shore up a faltering bond.
But the truth is Zane and I are still very much in love, and his desire, long-held but denied, is one I have always believed would positively transform his life. In the four years we�ve been together, I have heard the hunger, and the fear, in his voice when he talks of chasing what always feels so impractical, seen the light in his eyes at the thought of so fully immersing himself in another culture he begins to dream in its tongue. And I have felt, too, his sadness, at confining himself to much less � which is why I have remained open to the possibility he may one day trade in his yearning for a wild and sweeter calling.
Nothing is definite, but we have been talking about now being the perfect opportunity. For quite some time, Zane has been ensnared in a painful listlessness. His many hopes and plans, so large and electric when I met him, have fallen to fallow ground amid bouts of depression that make motivation a fleeting companion.
The flint of resolve needed to steer himself toward more expansive possibilities has been at best flimsy, but with his lease up in May, and no option to renew, it seems life has decided to force his hand, to quite literally push him out of his inertia.
It would be easy for him to simply find another apartment or house to rent, easier still to invite him to move in with me. We have talked noncommittally about both of those options, but I admit I get excited at the prospect of him packing up his life for a six-month sojourn abroad. Maybe it is naivete or foolish optimism on my part to believe this would not be a burden to our relationship, that somehow, over such a span, our happily tethered hearts would be immune to tendrils of doubt and mistrust.
I know it will not be easy. I know I will be sad. I will miss him terribly, worry, at times obsessively, and no doubt question the choice we have made. He may decide to stay wherever he goes. His life, and mine, may take completely different paths that sunder the ties we hold dear. It might even be wiser, especially if he decides to travel for six months or more, to make our break at the start rather than face a yawning unknown.
There is so much to weigh and consider. Zane himself has said being away from me and his family are his biggest reservations.
But this, too, I know: I will celebrate every moment that feeds his spirit, wakes his dreams and opens him up to his life. This, to me, is what you wish for those you love, the courage and freedom to inhabit the very marrow of joy, to rouse from their slumber the most vibrant of imaginings. To be so fully alive and immersed in what brings us deep fulfillment may require leaning into our fears and releasing their weight to the past. And, without trying to be sacrificial or saintly, this is what I want for Zane, that in daring to tear down his own darkness, he will discover the gold in its wake.
It was he, after all, who first reached for me with such a generous love in his hands. Years ago, when we�d gone our separate ways, these words, in a text he sent, baffled me: �I want you to be completely free in your life,� he wrote. Considering they were followed by �I love you always,� I was thrown into a tizzy of analysis. Was he saying he was letting me go, even though we were already no longer together, but that he would always love me? Was he saying he�d been hoping for reconciliation but was now abandoning hope? Did he mean there were loose ends he wanted to talk about so we could both move on with our lives? What was he trying to say?
As it turned out, he, too, wanted all I am now wishing him. By saying he wanted my freedom, he later acknowledged he was supporting the highest vision of what I hoped for my life. He was looking forward to the day when I would be released from all that was holding me back and cast, willing and eager, at the wide-open gate of my dreams, even if he would not be there to witness that surfeit of joy.
When I talked, after we reunited, of a yearning to work with kids in Africa, I joked I might not return from whatever country I chose to visit. His simple response was, �That would be a sad but glorious day.�
That absence of neediness, even while we both realize how difficult that kind of separation would be, has made me feel more loved than a vow of eternal devotion ever could.
Yes, I do think it would be amazing if we took off together for distant shores someday, and I have been known to utter many a sentence beginning with, �When we move to Brazil ....� But for now, while I�m rooted to a house I just bought and other commitments that will see me well into next year, I am open to Zane doing whatever it will take to shake him from this stasis.
Even if the experience of living in another country challenges him in less-than-comfortable ways, it seems a more exhilarating path than walking the one he�s been on. And if not now, then when? We�re young, unmarried and living in an age of instant global connection. We�re also so much in love I can only hope that connection is the one to ultimately sustain us wherever his heart may roam.
Life in LaLa Land appears every other Sunday in the Life section. Naila Francis: 215-345-3149; email: nfrancis@phillyburbs.com;
Twitter: @Naila_Francis
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Top Skip to content
Representing Clients Nationwide
Accepting Product Liability, Defective Pharmaceutical Drug, and Medical Device Cases Throughout the Country
GoldenbergLaw, PLLC specializes in mass tort lawsuits. Mass tort cases are often consolidated in a multi-district litigation (MDL) for purposes of discovery and bellwether trials. This means that cases pending across the country are consolidated before one Federal judge in order to promote efficient and uniform handling of the litigation. Plaintiffs from all over the country can file into an MDL, but each case in an MDL is still considered on its own merits. GoldenbergLaw has represented thousands of clients nationwide in MDLs. All four of GoldenbergLaw’s attorneys currently hold leadership positions on MDL Steering Committees and have worked extensively on cases filed in MDLs across the country. We have over 30 years of experience and have recovered over $100 million in verdicts and settlements. You deserve justice and advocacy.
Reach out to GoldenbergLaw, and leave the sleepless nights to us.
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Surgical Heater-Cooler Devices Are Causing Deadly Infections
Posted on 12/01/2016Back
WHAT IS A HEATER-COOLER DEVICE?
A heater-cooler device provides temperature controlled water to 3 types of devices:
(1) oxygenator heat exchangers;
(2) heart paralysis heat exchangers; and
(3) warming/cooling blankets.
Here is how it works:
The heater-cooler device has a tank of water. It heats or cools the water as needed, and then pumps that water out into one of the above-mentioned devices. In all three of the above-mentioned devices, the heater-cooler is a “closed system.” Think of a closed system as a circle, where the hot/cold water continues to circulate. Water is brought to the desired temperature in the tank, pumped out to the attached device, and then pumped back into the tank to be reheated or re-cooled. This process repeats itself as needed. The heater-cooler device maintains its own temperature through the use of an exhaust vent which blows hot air out of the machine to cool it down.
WHAT IS GOING WRONG?
Unfortunately, heater-cooler devices manufactured by the German company – LivaNova PLC – have been harming patients across the U.S. The device causing harm is called the “Stöckert 3T.” There are about 2,000 of them in the U.S.
These devices are infecting patients with Mycobacterium chimaera. This bacterial infection grows within the water tank of the heater-cooler, but the exhaust vent is the true problem. Particles of infected water from the tank are blown out of the machine through its exhaust fan into the air (“aerosolized”). This aerosolized Mycobacterium then floats out onto the patient’s open wound or implant infecting the patient. A report from the U.S. Center for Disease Control and Prevention says that not only can Mycobacterium grow in the heater-cooler’s water tank at the hospital, but some water tanks are shipped from the factory with the Mycobacterium already living inside it.
MYCOBACTERIUM CHIMAERA INFECTION
Mycobacterium generally isn’t harmful to healthy people, but it can lead to serious infections for others. If left untreated, these infections can be fatal. For example, in 2014, Mycobacterium infected 15 patients at a hospital in South Carolina. Four of the infected patients died. Although all four of the patients who died had complex medical conditions, authorities admit that the infection may have contributed to their deaths.
RISK FACTORS AND SYMPTOMS
Patients at the highest risk for being harmed from a Mycobacterium infection are those who: have an already weakened immune system, have lung disease, have diabetes, are undergoing chemotherapy, or are receiving an implant or transplant.
Mycobacterium grows slowly. Consequently, it can take months, even over a year, to develop into an infection. Symptoms of Mycobacterium include:
Fatigue;
Fever;
Pain;
Redness, heat, or pus at the surgical site;
Muscle pain;
Joint pain;
Night sweats;
Weight loss;
Abdominal pain;
Nausea; and
Mycobacterium infection can be treated. For most patients, a combination of antibiotics will do the trick. But for patients who developed a Mycobacterium infection after undergoing heart-valve surgery, a revision heart-valve surgery is necessary. Stöckert 3Ts are used in about 60 percent of all heart surgeries in the U.S. Therefore, if you experience any of the above-named symptoms following heart surgery make it a priority to visit your doctor to rule out a potentially fatal infection.
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GoldenbergLaw, PLLC is a personal injury and products liability law firm that serves injured clients nationwide.
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News of Alumni: David Costabile ’85 and Christian Gehring ‘07
David Costabile ’85 and Christian Gehring ’07 both appear in the new Netflix movie The Dirt, a biopic about Mötley Crüe's rise from the streets of Hollywood to the heights of international fame in the 1980s. The film was released on Friday, March 22, 2019.
David stars as Mötley Crüe band manager, Doc McGhee, and Christian plays David Lee Roth from Van Halen.
Congratulations, David and Christian!
David Costabile ‘85 plays longtime Mötley Crüe manager Doc McGhee
Christian Gehring ‘07 plays Van Halen singer David Lee Roth
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Client News: New justice complex relies on Tubelite to help balance transparency with security, inside and out
Posted on June 14th, 2016 by Heather West
Opened in March, Michigan's new $23 million Gull Road Justice Complex improves operational collaboration through efficiencies in space, design and function. The 85,000-square-foot, three-story building also houses the family division of the Kalamazoo County Circuit Court. TowerPinkster worked with the County to design a facility that conveyed a transparency and connection to the community, while providing a secure and functional structure.
Helping bring this vision to life and meet the multiple performance requirements, the architectural team selected numerous systems from Tubelite Inc. Working closely with construction manager AVB Inc., and Double O Supply & Craftsman, Inc. installed more than 14,400 square feet of Tubelite's curtainwall and storefront on both the interior and exterior. Double O also installed the entrance systems and exterior sun shades.
"Curtainwall is an important part of the design solution identifying the public realm of the building and to wash the lobby space with natural north light. The proceedings inside the building can be very stress filled and the introduction of natural light can aid in reducing the tension," noted TowerPinkster's project manager and architect, Eric Hackman, AIA.
"Courthouses play a unique role. They must reflect the dignity and importance of the work performed within their walls, and at the same time they must provide space and accommodate the tools needed to accomplish that work," said Kalamazoo County Probate Judge Curtis J. Bell, according to the Kalamazoo Gazette.
The new building consolidates a number of offices and departments, including the probate and juvenile courts, which previously were located in multiple buildings. Constructed on vacant land, Kalamazoo County's new justice complex features judges' chambers, hearing rooms, courtrooms, holding rooms, and offices for the court clerk, Friend of Court and county prosecutor. An enclosed walkway connects the facility to the Juvenile Detention Center.
According to TowerPinkster, exterior building materials were carefully selected to tie to the adjacent juvenile center, while blending with the surrounding neighborhood. To ensure the desired look and performance, TowerPinkster specified Tubelite's 400 Series curtainwall as the basis for design. Additional systems included T14000 Series storefront, Max/Block™ sun shades, E4500 Series (INT45) interior framing and Wide Stile Doors.
As part of its overall contribution to the project, Tubelite's team provided the take-offs. Once approved, these drawings guided the manufacturing process for the myriad exterior and interior systems. "There's a lot of Tubelite systems on this project. It has a little bit of everything," says Neil Krumrei, an estimator and project manager with Double O. "We use Tubelite whenever we can."
A self-described "old school guy," Krumrei adds, "I really like this project. I've been doing this for 35 years. From what I've seen, things went as well as could be expected for a project of this size. There's always something that doesn't go quite to plan, but we have good working relationship with AVB and Tubelite. It doesn't take long to make adjustments when needed."
In Jan. 2015 with temperatures as low as 11ºF, Double O's glaziers began installing Tubelite's curtainwall and storefront systems to enclose the facility's exterior. Making installation as easy as possible, Tubelite's 400 Series curtainwall uses an exterior screw-applied pressure bar to secure the glass in place. In total, more than 400 glazing units were installed on the north elevation alone.
The north and west elevations are wrapped in Tubelite's curtainwall with portions topped in clerestory windows created using Tubelite's 4.5-inch-deep storefront system. The main, north entrance features an 8-inch-deep curtainwall soaring up to 32 feet high and installed in angled segments to form a concave curvature. Walking through the front doors, the north lobby can accommodate up to 30 people. On the interior, the secured vestibules are comprised of Tubelite's 8-inch-deep curtainwall and 8-foot-tall Wide Stile Doors.
Maintaining the natural light and security on the interior, Tubelite's interior framing system with security glazing creates a sense of openness for the Friend of the Court area. This is where services are provided to parties with minor children involving divorce, family support, interstate and paternity cases. "To provide a see-through separation, we installed E4500 as free-standing interior windows," describes Krumrei. "Horizontal open slots are carefully positioned to allow for documents to be passed through."
A transparent connection between interior and exterior takes the shape of a 52-foot-tall staircase tower formed with Tubelite's 8-inch-deep curtainwall on the south elevation's mostly brick exterior. A small portion of the ground-floor uses the same system. Throughout the south and east elevations' brick exterior, large openings allow for daylight and views. Most of the openings are 4 by 8 feet with some as large as 8 by 8 feet. In each is installed Tubelite 4.5-inch-deep storefront fitted with a 20-inch airfoil sun shade to manage unwanted solar heat gain. Cooling costs can be significantly lowered with sun shades, while still allowing natural light to fill the workspace.
Further supporting occupants' comfort and heating and cooling cost savings, the PPG Solarblue® glass in Tubelite's systems helps in lessening the demand for electric lighting and reducing HVAC loads. Fabricated into insulated glass units by Thompson I.G., the sparkling, light, sky-blue appearance balances high visible light transmittance of 50 percent and a solar heat gain coefficient of 0.49. Security glazing also was used at the ground level and in designated areas.
Along with contributing to a safe, energy-efficient and stylish facility, Tubelite's systems are finished for long-term durability with minimal maintenance. Linetec finished all of the aluminum framing, doors and sun shades in a Class I clear anodize. The resilient finish will protect the justice complex's metal framework and preserve its appearance for many years to come.
Installation of Tubelite's systems on both the exterior and interior was substantially completed by Dec. 2015. Following a dedication ceremony in Feb. 2016, the facility was operational in early March. The project was delivered on time and budget.
Gull Road Justice Complex, 1536 Gull Rd., Kalamazoo, MI 49048; http://www.kalcounty.com/court
* Owner: Kalamazoo County; Kalamazoo, Michigan; https://www.kalcounty.com
* Architectural programming and design: HOK; http://www.hok.com
* Architect: TowerPinkster; Kalamazoo, Michigan; http://towerpinkster.com
* Consulting structural engineers: Nehil • Savik; Kalamazoo, Michigan; http://www.nehilsivak.com
* Construction manager: AVB Inc.; Portage, Michigan; http://www.avbinc.com
* Glazing contractor: Double O Supply & Craftsmen, Inc.; Byron Center, Michigan; http://www.doubleo-sc.com
* Glazing systems – manufacturer: Tubelite Inc.; Walker, Michigan; http://www.tubeliteinc.com
* Glazing systems – glass manufacturer: PPG; http://www.ppgideascapes.com
* Glazing systems – glass fabricator: Thompson I.G., LLC; Fenton, Michigan; http://www.thompsonig.com
* Glazing systems – finishing provider: Linetec; Wausau, Wisconsin; http://www.linetec.com
* Video: http://videos.mlive.com/mlive/2016/02/take_a_tour_of_the_new_gull_ro.html
* Photos provided by: Double O Supply & Craftsmen, Inc. and AVB Inc.
Filed under: Linetec, Projects, Tubelite Inc.
Story Resources
Photo 1: provided by Double O Supply & Craftsmen, Inc. and AVB Inc.Photo 2: provided by Double O Supply & Craftsmen, Inc. and AVB Inc.Photo 3: provided by Double O Supply & Craftsmen, Inc. and AVB Inc.Photo 4: provided by Double O Supply & Craftsmen, Inc. and AVB Inc.Photo 5: provided by Double O Supply & Craftsmen, Inc. and AVB Inc.Word documentRequest high res photographs for publication
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Little Caesars to Deliver Pizza Nationwide for the First Time Ever
Little Cae...
Are you Hot-N-Ready for cheesy bread delivered right to your door? For the first time ever in the company's 60-year history, Little Caesars will offer delivery service nationwide through a partnership with DoorDash - and there's no minimum order.
The Best Pizza in Every State
"We've seen such expensive and complex pricings throughout the pizza industry, and we think it's crazy," Little Caesars president and CEO David Scrivano said in a statement.
Compared to other chains, Little Caesars is cheap. A large cheese pizza costs $7.99 (with a maximum total delivery charge of $5.99), whereas Domino's is $14.99 with a $4.99 delivery fee ($15 minimum), Pizza Hut's is $13.99 with a $4.99 delivery fee ($20 minimum) and Papa John's is $15.99 with a $3.49 delivery fee ($10 minimum). These rates are for New York-based locations, so prices may vary.
In an email, a representative for Little Caesars told The Daily Meal the chain hasn't offered delivery in any capacity in more than 20 years, well before introducing Hot-N-Ready in 2004. A few franchisees had their own previous agreements with third-party delivery providers, most of which have ended by now. With the national launch on Jan. 6, the Little Caesars app and website will be the exclusive way to get delivery.
To order, open the Little Caesars app or website, pre-pay and then choose delivery. A DoorDash Drive delivery person will bring it to you. Cheap prices and Hot-N-Ready slices are just two things that make Little Caesars one of the best pizza chains in America.
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Strictly Come Dancing 2018: Stars seen with professional dancers for the first time
Preparations for this year's Strictly is officially underway!
August 21, 2018 - 19:28 BST Sharnaz Shahid The celebrities of this year's Strictly Come Dancing have joined the professional dancers for their first rehearsals. See the Instagram posts here...
After confirming this year's complete Strictly Come Dancing celebrity line-up, the stars have finally been introduced to the professional dancers. On Tuesday, the official Strictly Instagram account released a series of videos, showing the celebrities bonding with one another as well as their potential dancing partners in what is set to be the biggest ever series with 15 couples. "So they're here, the cast - they are about to meet their pros," show host Claudia Winkleman teased. "They are quite nervous. Tess is over there looking after them."
The cast of this year's Strictly have started rehearsals
After warming up, Ashley Roberts shared: "We've met everyone, it's all really happening. We all have butterflies because this is just the beginning. I'm so excited." Day one of rehearsals kicked off shortly after Susannah Constantine and Charles Venn were announced as the final two stars to join the cast. The pair join Paralympian Lauren Steadman, Blue's Lee Ryan, comedian Seann Welsh, news reporter Kate Silverton, singer Ashley, journalist Stacey Dooley, This Morning's Dr Ranj, Capital FM presenter Vick Hope, cricketer Graeme Swann, Danny John Jules, YouTube star Joe Sugg, Steps singer Faye Tozer and author Katie Piper.
MORE: The complete 2018 Strictly line-up
Strictly returns to BBC One this autumn
Strictly fans will have to wait a little while longer to find out which dancers the celebrities have been partnered up with. According to dancer Neil Jones, the stars are matched to professionals based on things like height. "Of course Brendan left, and we didn't want him to go, but he's six foot something," the professional said of replacing former pro Brendan Cole via The Sun. "I'm a lot smaller than him, so it now all depends on the celebrities. Because Brendan danced with Charlotte [Hawkins] last year and there’s no way I would've been able to dance with her because she's taller than me." Strictly Come Dancing will return to BBC One in the autumn.
Claudia Winkleman
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The 25 Most Spectacular Holiday Light Displays in the U.S.
The 25 Mos...
Twinkling lights, illuminated displays and nightly festivals and attractions are just a few of the things that help to make the holidays the most magical time of the year. And while a simple neighborhood light show can be perfectly charming, some light displays go all out to amaze onlookers.
Holiday light displays are a popular seasonal attraction; they have long been a tradition throughout the United States and an essential part of Christmas celebrations. Communities come together and families make new memories as towns, parks and popular sites are transformed into magical displays. Whether you would rather walk through a synchronized music light show, drive through 3 miles of more than 700 lit-up displays, or take a stroll through a glimmering botanic garden, there is something for everyone on this list of spectacular light displays in the U.S.
Visit Indiana
River of Lights (Albuquerque, New Mexico)
Each year, the ABQ BioPark Botanic Garden hosts the River of Lights - New Mexico's largest walk-through light show. Experience millions of sparkling lights, a synchronized music light show, more than 400 glowing light displays, and animated sculptures.
River Of Lights
Holiday Festival of Lights (Charleston, South Carolina)
Millions of multicolored lights will shine bright in the sky at Charleston's James Island Park for the Holiday Festival of Lights from November 9 through January 1. Journey through 3 miles of more than 700 light displays. USA Today named this display one of the "10 Best Light Shows in America."
Sarah R./Yelp
Bentleyville Tour of Lights (Duluth, Minnesota)
Head to Duluth, Minnesota, between November 17 and December 26 to see America's largest free walk-through lighting display. More than 200,000 visitors come to this 20-acre park, situated on the shores of Lake Superior, each year to admire this display of over 5 million lights.
Courtesy of Bentleyville Tour of Lights
Lights on the Bay (Annapolis, Maryland)
Head to Sandy Point State Park and take a scenic drive along the shore of the Chesapeake Bay for this incredible drive-through holiday light show. It features more than 60 animated and stationary displays. This season's show will run from November 17 through January 1 from 5 to 10 p.m. nightly.
Lights on the Bay
Magic Christmas in Lights (Theodore, Alabama)
Located in the Bellingrath Gardens, the Magic Christmas in Lights is celebrating its 23-year anniversary. The 65-acre garden estate is lit up with over 3 million lights and 15 scenes that are accompanied by nightly choral performances. Flower bulbs during the day are illuminated with light bulbs at night. It is truly a mesmerizing experience.
Ashley H./Yelp
Trail of Lights (Austin, Texas)
With four magic tunnels, 40 displays, 2 million lights, food, music, and a 55-foot tree, it's no wonder Austin's Trail of Lights made the list. Decorate your own tree along the trail or become a trailblazer by adopting one of the Trail of Lights iconic displays. 2018 tickets will be available from December 2 through December 23.
Arcadian B./Yelp
Busch Gardens (Williamsburg, Virginia)
With more than 10 million lights, Busch Gardens is home to one of largest Christmas light displays in North America. They put on quite the show in Christmas Town. The 50-foot-tall central Christmas tree alone has 500,000 lights that glow to a musical show that plays every half hour.
Drew P./Yelp
Kauai's Festival of Lights (Lihue, Hawaii)
Winter is a great time to visit Hawaii, and this year marks the 22nd annual Festival of Lights in Kauai's Historic County Building. The opening ceremony is on December 1, 2018, at 6 p.m. It is open on Fridays, Saturdays and Sundays December 1 through December 24. Families will enjoy admiring the beautiful lights and participating in "Santa's Workshop Events" where volunteers create folk art and new ornaments.
Courtesy of Kauai's Festival of Lights
The Coeur D'Alene Resort Holiday Light Show (Coeur D'Alene, Idaho)
With over 1.5 million lights, Idaho's top resort, the Coeur d'Alene Resort, is home to the country's largest holiday light display on water. Visitors take a boat cruise to experience the millions of twinkling lights and 250 floating scenes. It takes more than eight weeks for the Resort's employees to prepare this display, using more than 5 miles of electrical wiring.
Michael B./Yelp
Nights of Lights (St. Augustine, Florida)
When it comes to decorating for Christmas, St. Augustine doesn't disappoint. The historic district is hosting the 25th annual Nights of Lights this year. The award-winning lights display - comprising over 3 million lights - can be viewed on foot, on a carriage ride, on a Christmas train, or from a helicopter or a sailboat.
Yelp/Andy J.
Dyker Heights (Brooklyn, New York)
When many of us think about Holiday Lights in New York City, we usually think about Rockefeller Center, but the truth is that Dyker Heights Brooklyn goes above and beyond. Homeowners participate in an unspoken competition for the most lavish holiday light display. Walk through Dyker Heights or drive through in your car to experience the joy.
Dyker Heights Christmas Lights via Vincent Gulizio
Fantasy in Lights (Pine Mountain, Georgia)
Located in Pine Mountain is the famous Callaway Gardens. Visit during the winter months for a chance to experience the Fantasy in Lights holiday lights and sound show. Admire glimmering lights, watch fireworks, visit the Christmas Village for photos with Santa, and bring the kids to an hour of storytelling and Christmas carols with Mrs. Claus.
Fantasy In Lights/Yelp
Nights of a Thousand Candles (Murrells Inlet, South Carolina)
Walk the paths of this unique display in South Carolina. Unlike the typical Christmas lights display, Murrells Inlet's Brookgreen Gardens illuminates its display with more than 4,500 hand-lit candles. Take in the 80-foot-tall tree while strolling with a cup of cider or cocoa and enjoying the seasonal sounds of carolers and handbell choirs.
Dani N./Yelp
Glittering Lights (Las Vegas, Nevada)
This completely LED-lit 2.5-mile glittering course with sounds and vibrant colors opens in November. More than 3 million lights and about 500 animated exhibitions will dazzle you. Glittering Lights has entertained more than 2.2 million people over the past 15 years. The display has been on many "best of" lists - best annual events by USA Today, best places to see Christmas lights by CNN Travel, and most over-the-top holiday displays by Huffington Post.
Yelp/Rob A.
Hersheypark Christmas Candylane (Hershey, Pennsylvania)
Rollercoasters, chocolatey treats and the Hersheypark Christmas Candylane make for the park's most festive time of the year. More than 4 million lights are put up around the entire park, including 200,000 that flicker in a choreographed light show. Visitors can also enjoy the incredible light display - Sweet Lights - from the comfort of their own cars.
Shadrack's Christmas Wonderland (Sevierville, Tennessee)
Originally starting in Tennessee, Shadracks's Christmas Wonderland has expanded to multiple locations in different states. The main location, in Sevierville, Tennessee, features hundreds of thousands of LED lights on more than 1,000 different light circuits. Enjoy the show as they blink along to Shandrack's recorded holiday songs.
Steven L./Yelp
The Legendary Lights of Clifton Mill (Clifton Mill, Ohio)
More than 4 million lights are put up over the course of three months to create the popular Legendary Lights of Clifton Mill in Ohio. Sparkling lights cover Clifton Mill - the gorge, riverbank, bridge, building and nearby trees. There's even a 100-foot "waterfall" of lights. Every hour, the lights all go out while Christmas songs play before majestically exploding back on all at once. There's also a synchronized light show alongside the covered bridge.
Ivet V./Yelp
Circle of Lights (Indianapolis, Indiana)
More than 100,000 people gather on Monument Circle the Friday after Thanksgiving to participate in the Circle of Lights. The 4,784 lights strung from the Indiana Soldiers and Sailors Monument will leave you breathless. This display continues through early January.
Gardens Aglow (Boothbay, Maine)
Visit the Coastal Maine Botanical Gardens to experience the largest light display in Maine: Gardens Aglow. Experience more than 650,000 lights that decorate the central gardens and buildings. The display will be held from November 15 through December 31.
Coastal Maine Botanical Gardens
Tacky Lights Tour (Richmond, Virginia)
Said to be the most over-the-top holiday light display in Virginia, Richmond's Tacky Lights Tour will have you in awe. The tour consists of over 50 houses, each with a minimum of 40,000 lights. (The Phifer family house, a highlight of the tour, has more than 1 million.) Visitors rent buses, trolleys and limos to view the spectacle.
Sara E./Yelp
The Lights of Christmas (Stanwood, Washington)
Stanwood is home to the largest light display in the Pacific Northwest, The Lights of Christmas. Wander through Warm Camp Beach and explore 15 acres covered with over 1 million Christmas lights. Enjoy the lights as well as live entertainment, children's activities, delicious foods and holiday shopping.
Yelp/Sheila H.
Oglebay Festival of Lights (Wheeling, West Virginia)
Visited by more than a million visitors each year, this park and resort in Wheeling, West Virginia, encompasses one of the best Yuletide displays in the country. The display is a 6-mile drive, covering 300 acres, and visitors can view approximately 70 illuminated installations. New holographic eyewear called 3D Sleigh Bands are offered this year, transforming the show into a magical holiday spectacle.
Catherine G./Yelp
The Riverside Festival of Lights (Riverside, California)
This year marks the 26th year of the Riverside Festival of Lights, located in Southern California. Hosted by Mission Inn Hotel & Spa, this display attracts more than 500,000 visitors every year. View approximately 200 animated figures, the world's largest man-made mistletoe and falling "snow." Families who choose to stay in the hotel for the night will be rewarded with a visit from Santa's elves.
Debra R./Yelp
Peacock Lane (Portland, Oregon)
This charming neighborhood in southeast Portland has been attracting visitors for decades. Visiting the lights on Peacock Lane has become a tradition. Enjoy free cider or cocoa while driving or walking by the four blocks of displays. See rotating Christmas trees, life-like replicas of your favorite holiday characters and thousands of sparkling lights.
Maya H./Yelp
Newport Beach Christmas Boat Parade (Newport Beach, California)
Hop aboard one of Newport Beach's fully decorated ships to capture views of this magical display. The Newport Beach Christmas Boat Parade runs for an entire week along a 14-mile route. While onboard, you will be rewarded with views of beautifully decorated homes, extravagant themed displays and more than 100 boats of different shapes and sizes on the shores of this warm city that knows how to do Christmas right.
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Hillcrest Bank 5800 E Bannister Rd Kansas City, MO 64134
by Henrietta / Monday, 19 August 2019 / Published in Banks That Offer Mortgages
Hillcrest bank 5800
Serving jackson county
Annual sales volume
Bank distilled spirits
Get directions, reviews and information for Hillcrest Bank in Kansas City, MO. hillcrest bank 5800 E Bannister Rd Kansas City MO 64134. Reviews (816) 965-3350 Website. Menu & Reservations Make Reservations . Order Online Tickets.
Bank Midwest Bannister branch is located at 5800 East Bannister Road, Kansas City, MO 64134 and has been serving jackson county, Missouri for over 32 years. Get hours, reviews, customer service phone number and driving directions.
5800 E 97th Ter, Kansas City, MO is a single family home that contains 946 sq ft and was built in 1958. It contains 3 bedrooms and 1 bathroom. The Zestimate for this house is $87,191, which has increased by $2,825 in the last 30 days. The Rent Zestimate for this home is $950/mo, which has increased by $4/mo in the last 30 days.
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Hillcrest Bank is located at the address 5800 E Bannister Rd in Kansas City, Missouri 64134. They can be contacted via phone at (816) 965-3350 for pricing, hours and directions. Hillcrest Bank has an annual sales volume of 1M – 1,999,999. .For more information contact Richard Oherron, President or go to www.hillcrestbank.com
Get reviews, hours, directions, coupons and more for Hillcrest Bank at 5800 E Bannister Rd Ste 200, Kansas City, MO 64134. Search for other Commercial & Savings Banks in Kansas City on The Real Yellow Pages.
Find Hillcrest Bank in Kansas City with Address, Phone number from Yahoo US Local.. 5800 E Bannister Rd, Kansas City, MO 64134 Cross Streets: Near the intersection of E Bannister Rd and Hillcrest RdNeighborhoods: Loma Vista (816) 965-3350; hillcrestbank.com; Directions. Reviews.
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Hillcrest Bancshares, Inc. is a Kansas For-Profit Corporation filed on August 15, 1986. The company’s filing status is listed as Merged Out Of Existence and its File Number is 0992255. The Registered Agent on file for this company is Kansas Corporation #2, Inc. and is located at C/O Lewis Rice & Fingersh 8900 State Line Rd Ste 333, Leawood, KS 66206.
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Home Reviews Strange But T...
Strange But True Review – EIFF 2019
Steven Neish
Five years on from the death of older sibling Ronnie (Connor Jessup), Philip (Nick Robinson) has returned to the family home with a broken leg and a bruised ego when his brother’s pregnant ex-girlfriend (Margaret Qualley) arrives at the door with an unlikely story to tell. She believes that the unborn baby is in fact Ronnie’s, an impossible assertion that stuns Philip but incenses his mother, Charlene (Amy Ryan). While Melissa prepares for the baby’s arrival, aided by kindly godparents Bill (Brian Cox) and Gail (Blythe Danner), Philip and Charlene embark on divergent quests to prove and disprove her story respectively, leading the former to a local psychic and the latter to her estranged husband, Dr. Richard Chase (Greg Kinnear).
The second feature from director Rowan Athale and an adaptation of John Searles’ 2002 novel, Strange But True opens with a frantic and frenetic chase sequence in which an injured Philip is pursued through dense forest by an unseen assailant. When the narrative then flashes back to suburbia, two days earlier, however, there is little sense of pending danger or anything out of the ordinary at all — only familiar familial conflict, as a grieving mother and her grown son clash over everything and everything. Melissa’s talk of posthumous conception and Philip’s subsequent encounter with her psychic point to supernatural influences, but as time passes and alternative explanations are explored an explicitly paranormal gear-change becomes ever more unlikely — though prescient clues in the psychic’s reading don’t rule it out either.
Instead, Carlene’s search begins to bear fruit. Her research reveals instances of posthumous birth where the father’s sperm was frozen shortly after death, and knowing that her ex-husband was working at the hospital the night her son was killed she begins to suspect that he might have something to do with it. Ryan is terrific in the role of grieving mother, a bristling ball of nervous rage who snaps at the slightest provocation and just about explodes when Melissa re-enters her life. She is not without justification, however, and many of her outbursts don’t just release tension but ring true. A good few even raise a smirk as she lambasts those around her. As angry as she is with Melissa and Richard, it’s an enduring antagonism with a coworker at her old workplace that seems to irk her most, though as the film progresses it becomes clear that this too stems from the accident — and through the films events she finally comes to terms with her pain.
The film is brilliantly acted, with each character clearly hiding something from someone — whether its an insecurity, a smoking habit or something more insidious. The characters of Bill and Gail never quite convince, or coalesce, but this is through no fault of Cox or Danner and more likely a result of their relative distance to the main, more involving drama. Each time the film revisits the day of the accident — a prom-night tragedy that plays out in flashbacks — something new is gleaned about the family and their bond grows ever stronger. Athale has done a masterful job not just of reconfiguring Searles’ page-turner for the big screen and casting an impressive roster of talent but of exploring grief and its many interrelated emotions in a way that is honest and insightful. The flashbacks are often as cathartic as they are explanatory, and while the third act twist takes the story on something of a tangent the various arcs that have been established keep everything grounded in characters you otherwise believe in.
That’s the thing about Strange But True; as the ethereal premise begins to lose some of its mystique the characters grow more corporeal and compelling, pulling you back in. When the cast do finally converge on the forest, and the chase begins in earnest, the context might have changed but the effect is much the same. You’re gripped all over again.
A wonderfully woven tale of grief, belief and the things we keep hidden.
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http://popcornaddiction.com
A big fan of adventure both on the big screen and off, I split my time between writing film reviews and updating my travel blog. Glasgow and Edinburgh Film Festivals provide me with the perfect opportunity to do both, sating my popcorn addiction while permitting me to travel the world one film at a time.
Strange But True Review
The Souvenir – EIFF 2019 Review
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Bluecrowne: A Greenglass House Story (Paperback)
By Kate Milford
Kobo eBook (October 2nd, 2018): $7.99
Hardcover (October 2nd, 2018): $17.99
Return to the world of the best-selling Greenglass House, where smugglers, magic, and pyrotechnics mix, in a new adventure from a New York Times best-selling, National Book Award–nominated, and Edgar Award–winning author.
Lucy Bluecrowne is beginning a new life ashore with her stepmother and half brother, though she’s certain the only place she’ll ever belong is with her father on a ship of war as part of the crew. She doesn’t care that living in a house is safer and the proper place for a twelve-year-old girl; it’s boring. But then two nefarious strangers identify her little brother as the pyrotechnical prodigy they need to enact an evil plan, and it will take all Lucy’s fighting instincts to keep her family together.
Set in the magical Greenglass House world, this action-packed tale of the house’s first inhabitants reveals the origins of some of its many secrets.
Kate Milford is the New York Times bestselling author of the Edgar Award-winning, National Book Award nominee Greenglass House, as well as Ghosts of Greenglass House, Bluecrowne, The Thief Knot, and many more. She lives with her family in Brooklyn, New York. www.greenglasshousebooks.com and www.katemilfordwritesbooks.com,
Twitter: @KateMilford
"Milford tucks strange places, odd artifacts, and people with mysterious pasts into a suspenseful tale properly supplied with sinister villains, clever twists, large explosions, and heartbreaking sacrifices...A tale to sweep new and confirmed fans into the author's distinctively imagined blend of history, magic, mythology, chemistry, and nautical lore. "--Kirkus, STARRED review
"The engrossing adventure, as well as the thoughtful depiction of a blended, multicultural family, are all draws enough on their own, but the glimpse of Milford’s bewitching world-building will leave readers eager to track down her other novels."--Booklist, STARRED review
"...Resplendent with time travel, Chinese folklore, nautical explanations, and the history of Nagspeake. This is a sophisticated tale filled with masterful world building, time travel, science, and nautical life."--School Library Journal
Series: Greenglass House
Maximum Age: 12
Juvenile Fiction / Fantasy & Magic
Juvenile Fiction / Family / Siblings
Juvenile Fiction / Fairy Tales & Folklore
Juvenile Fiction / Paranormal, Occult & Supernatural
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You are at:Home»News Type»Featured News»Brookstone Recharges Brand, Eyes Retail Expansion
Brookstone Recharges Brand, Eyes Retail Expansion
By Matthew Kramer on September 28, 2015 Featured News, Health & Personal Care, Home Décor, Home Environment, Organization & Cleaning, Retail, Small Electrics, Vacuum Cleaners/Electric Cleaning, Web Briefs
Brookstone Air Cleaners
After a spell in Chapter 11, Brookstone is exploring new routes to product innovation and new routes to the consumer via partnerships with other retailers.
As it celebrates its 50th anniversary in business this month, Brookstone executives want to ensure the business enters a new operational phase that opens fresh opportunities.
Tom Via, Brookstone president and CEO, told HOMEWORLD BUSINESS® that Brookstone is focused on being first to market with a wide range of cutting-edge products. “Our mandate, a big piece of it, is widening the innovation pipeline,” Via said. “We’re looking in places we didn’t look before rather than taking just the traditional way of approaching things.”
With developments such as crowd funding and product incubator operations, Brookstone has a chance to get involved with inventors, makers and the array of independent product developers who are looking for ways to bring their concepts into life. The company is going “earlier upstream” to work with those who are introducing fresh product concepts and solutions that will excite and entice consumers, Via said.
Beyond Brookstone
At the same time, Brookstone has launched a program that is taking a new approach to reaching retail customers. Headed up by former Spectrum Brands executive Kevin Blossom, now operational vp/wholesale at Brookstone, the goal is expanding the Brookstone brand at retail by creating boutique, curated product assortments for major retailers.
Blossom noted that Brookstone has a catalog of thousands of products and, with a renewed emphasis on innovation, is constantly updating its assortment with items that build on emerging consumer interests. Brookstone can work with outside retailers to assemble a coherent selection that works in their market sector.
“We’ll vary by channel,” Blossom said. “We can play in a lot of areas.” The program launches with an emphasis on electronics, bed toppers, travel, gifts and entertainment. However, the program is meant to be flexible and welcome variation, so gifts might differ depending on the retail partner, including wine accessories, for example, if such products are identified as an opportunity.
Blossom said Brookstone hopes to have products on store shelves other than its own within the next several months and at least by spring 2016.
For more on Brookstone, see the September 28 issue of HOMEWORLD BUSINESS®. With this issue: Forecast 2016, an in-depth study of consumer housewares purchase behavior and preferences across 17 core categories.
appliances branding Brookstone catalog crowd funding ecommerce electronics gifts health inventors Kevin Blossom personal care product development Tom Via wellness
Lowe’s Investing In Technology To Improve Customer Experience
NRF Confronts Consumer Data Privacy
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Map to OBMS
SCHOOL MSDS
2019-2020 Club Announcements
HOSA - Future Health Professionals
Running Clulb
Carolina Forest High School Athletics
B Team Baseball
Stingray News Blog
HCS Resources for Parents
Parent/Student Guide
PowerSchool Parent Login
MySchoolBucks-Cafeteria
7th Grade Science Weekly
OBM PTO Website
Stingray Family Events
Stingray Spirit Wear
~ 2017-18 Interscholastic Sports Pre-participation Forms
Athletic Forms for Interscholastic Sports
Meets the 4th Tuesday of each month from 3:30 - 4:45 PM in room 713.
What is HOSA and the Middle School Division?
The Middle School Division of South Carolina HOSA is for middle school students (Grades 6-8) who are interested in a career in health care. SC HOSA organization has been designated as a Career and Technical Student Organization (CTSO). HOSA - Future Health Professionals provides a unique program that helps students with LEADERSHIP SKILLS, PHYSICAL, MENTAL, and SOCIAL ENHANCEMENT, CAREER GUIDANCE, JOB PREPARATION, SELF-WORTH, MOTIVATION, AND EMPOWERMENT! The Middle School Division allows students the opportunity to learn more about the healthcare field which can be used to define a possible future occupation, and the skills learned can be used for a lifetime!
Cost Total $30.00
-$15.00 official membership registration -$15.00 HOSA Shirt
Why Affiliate With HOSA?
HOSA is the only career and technical student organization designed to exclusively serve the needs of students in health science training programs.
HOSA is for and led by, students.
HOSA is recognized by the S. Department of Education and the Health Science Education Division of the Association of Career and Technical Education (ACTE) as an integral part of such education.
HOSA promotes and develops respect among students, teachers and the community for Health Science Education.
HOSA provides opportunities for students to sharpen their occupational awareness and skills while developing valuable leadership qualities.
HOSA members learn to appreciate their ability to help people who need health care or a better understanding of health-related issues. Getting involved in health issues is central to HOSA.
HOSA promotes the development of good decision-making skills that can help members reach full career potential.
HOSA promotes fellowship through social and recreational activities.
HOSA provides members with leadership training
PRINCIPAL: Mrs. Barbara McGinnis
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ScienceInverse DailyShareSubscribe
Inverse Daily: Discovery of Ancient Diamonds Reveals Glimpse of Early Earth
Thanks to some some “superdeep” diamonds in Brazil, we now have confirmation that there’s an ancient reservoir holding clues about the early evolution of our planet.
By Yasmin Tayag
Filed Under Earth Science, History & Planets
Happy Friday, Inverse Daily fam. While I’m here plastering my home with the official photos of Helena Bonham-Carter (Princess Margaret) and Olivia Colman (the QUEEN!) from Season 3 of The Crown, let’s get you ready for the weekend.
You’re reading an adapted version of the Inverse Daily newsletter. Subscribe for free and earn rewards for reading every day.
INVERSE QUOTE OF THE DAY
“What did surprise us though was the sheer number in some of the samples.”
— Marine ecologist Melanie Bergmann, Ph.D., who found a heck of a lot of microplastics in the Arctic snow, far from the waters where they’re usually found.
Find out how the water-bound pollutants made it so far up the poles.
Loyal Inverse Daily readers know all about the great strides we’ve made in clean energy — solar is now cheaper than coal in many places, and wind turbines are quietly powering huge regions — but just because our energy is green doesn’t mean the things that use it can’t get greener. One big area for improvement, Mike Brown tells me, is our buildings. Tall, shiny skyscrapers, the kind that define a city’s downtown core, have plenty of room for improvement.
Think about the way some buildings still have all of their lights on in the dead of night, or how even your own office may blast the AC when nobody’s there. These impressive towers are energy sinkholes because their systems for heating, cooling, lighting, and ventilating tend to be inefficient, say researchers in a new report. They recommend upgrading a building’s walls and windows to maintain the temperature without resorting to a energy-hungry thermostat, switching heat pumps to an electricity-powered system, and installing smart tech so that power isn’t used needlessly.
Check out their full recommendations here (and please turn off the AC when you leave work this weekend!).
The more you know:
Solar Energy Prices Hit Tipping Point as China Reaches ‘Grid Parity’
Wind Energy: How Bigger Turbines Could Reduce Prices and Boost Power
These days, you can get a Ph.D. in a bunch of unusual fields, from manga to thanatology (the study of death). But the doctoral program that Suzette Timmerman went through takes the cake. Timmerman, who talked to Emma Betuel about her stunning new research this week, did her Ph.D. in diamonds.
She’s the discoverer of a “super deep” birthplace of the precious gems deep beneath our feet, some 140-500 miles below. Rather than eyeing them to start an engagement ring business (mining them would make it even more prohibitively expensive), she’s using them to sneak a glimpse of the infant Earth. These diamonds, which were pulled from remote mines in western Brazil, contain higher-than-usual amounts of a rare, valuable isotope called helium-3 — sometimes called “the primordial isotope” — which is thought to have been created at the beginning of our planet.
Check out diamonds like you’ve never seen them.
Scientists Discovered a Quadrillion Tons of Diamonds Hidden Deep Within the Earth
Strange Diamonds Reveal ‘Ice-VII’, a Form of Frozen Water We’ve Never Seen
Electric Equality
China’s reputation as both the world’s more populous country and the world’s largest polluter is no secret. But the nation has swiftly made impressive strides to address its soiled environmental record. Its publicly stated goal is to get 20 percent of its power from renewable energy by 2030, and it looks like that goal is within reach. For a long time, high solar prices made fossil fuels the more convenient choice, but new research now shows that China has reached a turning point.
As Mike Brown tells me, home-generated solar power in China is now cheaper than electricity generated from the national grid. In 22 percent of cases, the price of solar even undercut the government-set benchmarks for subsidized coal. Now if only researchers could figure out how its solar panels can capture the sunlight blocked out by all of the existing air pollution…
Read up on the importance of China’s green energy turning point.
Solar vs. Coal: Why the “74 Percent Report” Signals a New Era for US Energy
China, the World’s Biggest Polluter, Will Soon Be a Wind Energy Giant
Sunday Scaries
Beat the “Sunday Scaries” with soothing science and relatable advice to get your mind & body ready for the week ahead.
Sign up here. →
Balancing the Scales
Diet culture hasn’t been great for our relationship with our weight. While there’s plenty of research showing that maintaining a healthy weight generally decreases the risk of many diseases, there are a ton of variables influencing what a healthy weight even is: the size of your frame, your muscle mass, whether you’re pregnant or not, and so on. The body mass index, which is your weight divided by your height, is used to address at least the most obvious snag, but even this has its issues.
Muscle cells weigh much more than fat cells, so becoming fit can often lead to a higher weight and a higher body mass. This paradox is obviously frustrating for people who are trying to attain a lean, muscular physique, because when you’ve been conditioned to think of weight as a metric for fitness, gaining it while working out feels like taking a step backward. But as science fellow Ali Pattillo tells me, there’s a movement in the fitness community to stop thinking about weight altogether.
Read up on the “Fitness Paradox” here.
Bodybuilding Researchers Uncover a Baffling Paradox in Men Who Use Steroids
You’re Probably Doing Cardio All Wrong: 2 Experts Reveal How to Train Smarter
Today’s Good Thing
Today, that’s the team of Australian scientists farming a fluffy pink seaweed called Asparagopsis taxiformis, which significantly reduces the methane in cow burps and farts when fed to cattle. If it can be scaled up — and if the cows like chowing down on it — it might be a game-changer for climate-friendly beef farming.
Meanwhile …
Scientists debunk a common theory about being left-handed.
Musk Reads: Tesla biohacker beats Neuralink, a small patch of solar could meet humanity’s energy needs, and a $25,000 Tesla looks more likely.
Actually, reusable coffee cups aren’t doing any good for the planet.
Leading health studies are wrong about how much salt we should consume.
Can runtimes predict the quality of Star Wars movies?
Inverse Loot
Subscribe to Inverse Loot and learn about these deals first.
The Highest Paying Cash Back Card Has Hit the Market
The Best Quality Earbuds for Every Budget Range
Get Ready for Fall Adventures With These Updated Wardrobe Staples
5 Great Messenger Bags Under $100
These Cold Brew Coffee Makers Are Perfect for Your Home
Thanks for reading, gang, and have a great weekend.
Think we should attempt to mine those superdeep diamonds? Let me know your thoughts at yasmin@inverse.com.
Posted in the back, diamond fangs in my grill,
— Yasmin
Inverse Daily: giant squid, decoded
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Inverse Daily: How ancient sex influences modern-day...
Inverse Daily: Why anxious people smoke marijuana
Inverse Daily: The Next Superbug
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Audi's Di Grassi takes last-gasp Formula E win in Mexico
Motorsport / 18 February 2019, 11:48am / Alan Baldwin
Lucas di Grassi celebrates his victory in the Formula E Mexico City ePrix on Saturday, February 16, 2019. AP Photo / Marco Ugarte.
Mexico City - Brazilian Lucas Di Grassi seized a last-gasp victory in a wild finish to the Mexico City ePrix on Saturday, with Belgian Jerome d'Ambrosio returning to the top of the all-electric Formula E standings.
Germany's Pascal Wehrlein had led from pole position in a race that was red-flagged after less than five minutes when Brazilian Nelson Piquet Jr. had a big smash.
Wehrlein led from the re-start but used too much energy defending on the last lap against Di Grassi and ran out of power within metres of the finish line as the former champion sped past to win for Audi at the Hermanos Rodriguez circuit.
"I think it was my best Formula E race ever," said Di Grassi, the fourth different winner in four races. "It was unbelievable. Wehrlein was very dodgy, closing the door and changing direction many times.
"I tried to put pressure on him, making him use energy and then in the last corner he just slowed down, tried to close the door and I crossed the line sideways."
Lucas di Grassi celebrates his victory. AP Photo / Marco Ugarte.
Mahindra driver Wehrlein, one of several ex-Formula One drivers in the series, was handed a five-second penalty after the finish for cutting a turn on the final lap, dropping him from second to sixth.
That left Portuguese Antonio Felix Da Costa in second place for BMW Andretti and Swiss racer Edoardo Mortara third for Venturi.
D'Ambrosio finished fourth, from 19th on the grid, to take over at the top of the standings on 53 points, seven clear of Da Costa on 46 and Britain's Sam Bird, the previous leader who dropped to third on 45.
Brazilian Felipe Massa, the former Ferrari and Williams F1 driver, scored his first points in Formula E with eighth place for Venturi, the Monaco-based team led by Britain's Susie Wolff. Bird was ninth.
Mahindra lead the team standings with 83 points to Bird's Virgin outfit on 73.
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OPINION: It wasn’t a good year for investors in equities
Invest / 14 January 2019, 09:45am / Martin Hesse
Martin Hesse. File Image: IOL
OH DEAR. Last year was not kind to investors. It was the worst year for the JSE since the Big Crash in 2008. And it started off so well, with all the optimism around our new president.
I won’t go into the reasons for the malaise, which differ according to the analyst you speak to. But let’s look more closely at the figures, which make for enlightening, although somewhat depressing, reading.
The FTSE/JSE All Share Index ended 2017 at 59504 points (after breaking the 60000 mark in November 2017). It ended 2018 at 52736 points, a drop of 11.4%. That’s low compared with the 27.5% drop in 2008, but here’s the rub: there hasn’t been a crash. Just lots of volatility, with most of it occurring in the last quarter.
Looking at the total return index (which measures share prices with dividends reinvested), the drop was a slightly more palatable 8.5%. This is the better indicator when considering the performance of your equity unit trust or exchange traded fund investments, because, unless you’re drawing an income, you’re likely to be reinvesting your dividends.
So how did our equity fund managers do in the tough times that were 2018?
Not too well, sadly. The average South African general equity unit trust fund was down 8.9%, according to ProfileData. Of the 163 funds in this sub-category, only two did not end in the red after costs: the Kagiso Islamic Equity Fund (up 1.7%) and the RECM Equity Fund (up 0.47%). The worst-performing funds were down as much as 20%.
It’s likely that the better-performing funds had a substantial exposure to our resources sector, the only sector to have done well in 2018. The worse-performing funds were most likely heavily invested in industrials, which had a miserable year. The darling of these stocks, Naspers, which featured large in many an equity portfolio, lost 16.5% of its value in 2018.
High-equity multi-asset funds also did poorly. These funds can have a maximum of 75% in equities, but the managers can reduce their equity exposure if the markets are looking dicey, switching to safer options such as bonds and cash. Of the 174 registered high-equity multi-asset funds, only a handful emerged in the black at the end of the year.
The average fund in this sub-category was down 3.7%, according to ProfileData. Star performers were the Gryphon Prudential Fund of Funds (up 5.4%) and the Olympiad BCI Managed Fund of Funds (up 5.24%).
Cash and short-term bonds were the best-performing local asset classes, delivering northwards of 7%.
The JSE was in good company on its downward slide. The Visual Capitalist website, which contains informative financial infographics, recently published a infographic titled “How every asset class, currency and sector performed in 2018”. It shows that most asset classes ended 2018 in the red, with the S&P 500 (which measures the 500 top American stocks) down 6.2%, emerging markets down 16.9%, and non-US developed market stocks down 14.5% (all in dollar terms which, it must be said, strengthened against world currencies by 4.6% in 2018).
We must make radical decisions, says Motsoeneng as ACM builds momentum
Amcu strike at Sibanye enters week nine
How companies like Apple sprinkle secrets in earnings reports
Inside PERSONAL FINANCE
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I Drink, Therefore I Am
By Rebecca Atkinson
156 Pages, 5.5 x 8.5
Formats: Trade Paper
Illumify Media Global (Aug 2019)
Can You See Me Yet?"I loved the way I felt when I was drinking. Alcohol was the magical nectar that made me feel free, pretty, popular, and invincible. When I drank, I wasn't invisible anymore. What could possibly go wrong?" Becky discovered alcohol as a college freshman. She started drinking during sorority Rush Week—and decided she never wanted to stop. Over the next three decades, Becky held more than a dozen jobs, moved eight times, divorced three men and married four. Alcohol clouded her judgment and ruined her life—until she found Jason, whose patience and prodding helped her find her way back to God and back to sobriety. I Drink, Therefore I Am is the inspiring story of a woman who challenged the odds and learned to thrive. Whether you've struggled with an addiction—or love someone who is struggling now—Becky's true confessions and honest insights will prove a healing elixir on your journey to freedom.
Becky Atkinson is a life coach and the founder of Life of Impact. She lives in Colorado.
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https://www.inforisktoday.com/
Phil Curran
Cooper University Health Care
Margaret Reid
Jennings Aske
New York-Presbyterian
Mitch Parker
Indiana University Health System
Top 10 Influencers in Banking InfoSec
Endpoint Security , Enterprise Mobility Management / BYOD , Governance
Analysis: The Merits of Medical Device Security Legislation
Cybersecurity Expert Joshua Corman Sizes Up the Bill and Its Potential Impact Marianne Kolbasuk McGee (HealthInfoSec) • August 23, 2017 20 Minutes
Joshua Corman, founder of I Am the Cavalry, and member of HHS' cyber task force
Recently proposed legislation could potentially put more pressure on manufacturers and healthcare entities to bolster efforts already underway to improve the security of medical devices, says cybersecurity expert Joshua Corman.
The Medical Device Cybersecurity Act of 2017, which was recently introduced by Sen. Richard Blumenthal, D-Conn., contains a number of provisions, including some that are similar to ongoing efforts in the healthcare sector, including work being done by the Food and Drug Administration and some recommendations that were issued earlier this year by the Department of Health and Human Services' cyber task force, notes Corman, who is a member of the task force.
"The bill caught a lot of folks flat-footed and confused because there's quite a bit in there that overlaps with what the FDA is already asking for in [its] pre- and post-market [medical device cybersecurity] guidance," Corman says in an interview with Information Security Media Group. "But that said, I think that it's a good thing to stimulate discussion.
"The act of putting [these provisions] into a bill potentially could get come good conversation ... on the record, in a hearing or other forum - some clarification on things," says Corman, who is founder of I Am The Cavalry, a grassroots, not-for-profit cyber safety organization.
In the interview (see audio link below photo), Corman also discusses:
The merits of specific proposals in the Blumenthal legislation, including provisions addressing medical device software patches, the creation of a report card to compare the security capabilities of medical devices, and ways to bolster remote access protections of medical devices;
Why some healthcare entities and medical device makers incorrectly interpret FDA guidance as "voluntary" guidelines that have no consequences if ignored;
Whether the Blumenthal legislation has a shot of becoming law;
Another legislative proposal to address the cybersecurity of the internet of things and how it relates to the proposed medical device bill.
In addition to his role at I am the Cavalry, Corman is the director of the Cyber Statecraft Initiative at the Atlantic Council's Brent Scowcroft Center of International Security. He is also a member of the Department of Health and Human Services' Cybersecurity Task Force. Corman formerly served as chief technology officer for Sonatype, director of security intelligence for Akamai, and in senior research and strategy roles for The 451 Group and IBM Internet Security Systems.
Legislation & Litigation
Changes Coming to NIST's Catalog of Security Controls
After 7 Months in Office, How's Trump Doing on Cybersecurity?
Election Hacking: What You Need to Know
© 2020 Information Security Media Group, Corp. https://www.inforisktoday.com/ Toll Free: (800) 944-0401
https://www.inforisktoday.com/interviews/analysis-merits-medical-device-security-legislation-i-3680
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The Biscoff Cookie and Spread Cookbook
I’m so excited to announce that today is the official publication date of The Biscoff Cookie and Spread Cookbook! To celebrate I’m giving away two CASES of Creamy Biscoff Spread along with signed copies of the book!
I filled this cookbook with 70 irresistible recipes featuring treats from cookies, muffins, breakfast sweets, frosting, and everything in between. Each recipe uses the delicious gingery, European cookie butter made from Biscoff cookies. You may know the famous cookies as the airline cookie that has been served in flights since 1985.
We’ve been counting down the months, weeks, and days to this official launch day! #BiscoffBook on Instagram
I hope you are excited to bake from this cookbook! If you’re a Biscoff fan, or even if you’ve never tried the delicious spread now is your chance to hit the jackpot! Not only am I giving away 2 signed copies of The Biscoff Cookie and Spread Cookbook but the winners are also getting a CASE of Creamy Biscoff Spread!
Let’s take a peek inside…
Biscoff Banana Streusel Muffins
Fudgy Biscoff Swirl Brownies
Biscoff Buckeye Cake
White Chocolate Biscoff Cookies
I have a lot of fun promotions planned over the next few months so I hope you’ll join me in celebrating this new cookbook! Thank you for all of your support. I could not have done this without YOU, and I wouldn’t have wanted to! THANK YOU!! The book is available for purchase in stores as well as online:
Lotus Bakery
I would ABSOLUTELY LOVE it if you share with me when you see a copy of the book! Snap a pic, upload it to your favorite social media platform and be sure to use the #BiscoffBook hashtag.
Now, let’s give away some books and cases of Biscoff spread!!!
Two (2) winners will receive:
1 signed copy of The Biscoff Cookie and Spread Cookbook by Katrina Bahl
1 case (8 jars) of Creamy Biscoff Spread
Please use the giveaway entry form and leave a comment on this post to be entered (You MUST leave a comment on this post; entries will be verified). By entering this giveaway you are agreeing to the Official Rules. This giveaway is a sweepstakes. Open to continental USA residents over age 18. Winner(s) will be chosen by random, announced here, and will be contacted by email. Winner(s) must respond within 48 hours to claim the prize or a new winner will be chosen.
All Recipes, Giveaways and Reviews
I’ll Bring the COOKIES Week 3 Wrap-Up and Giveaways
Salted Caramel Pie Slice Cookies
Green Smoothie Parfait Popsicles
207 Responses to “The Biscoff Cookie and Spread Cookbook”
Amanda — November 3, 2014 at 6:22 am
So HAPPY HAPPY HAPPY for you!! Today is a beautiful and wonderful and amazing day!! Your book is WONDERFUL! Perfect. I adore it and you!
Katrina Bahl — November 22, 2014 at 8:44 am
Thanks for sharing in the happy day with me 🙂
Jen — November 3, 2014 at 6:55 am
I can’t wait to get my hands on this book!
Nayana Catoia — November 3, 2014 at 7:00 am
Delicious! So wanting this beautiful gifts
Liz — November 3, 2014 at 7:07 am
CONGRATULATIONS! I”m so thrilled for you and your success!!! xoxo
Lisa @ Garnish with Lemon — November 3, 2014 at 7:27 am
I am SO happy for you! This books looks gorgeous and I CANNOT wait to get my hands on a copy of it! Biscoff love forever!
Kait L — November 3, 2014 at 7:29 am
Congrats!! This cookbook looks fantastic!
[email protected]+Baked+by+Rachel — November 3, 2014 at 7:35 am
Soooooooo excited for you! And duh a whole case + a signed book would be awesome 😉
Bryn — November 3, 2014 at 7:46 am
Congrats on the book! Can’t wait to get my hands on it.
Betsy | JavaCupcake.com — November 3, 2014 at 7:50 am
Congratulations! 🙂 This is so exiting! I can’t wait to share this book with my European readers… they’re going to LOVE IT since they’re crazy about anything Biscoff and speculoos!
Thank you Betsy! Thanks for sharing in my happiness about this project from the start!
Kayle (The Cooking Actress) — November 3, 2014 at 7:51 am
YAYYYYYYY!!!!!!!!!!!!!! I am so so excited for you and it looks like your cookbook is absolutely packed with deliciousness! Love Biscoff and you <3 😛
Thank you Kayle!
Chelsea @chelseasmessyapron — November 3, 2014 at 7:52 am
CONGRATS on an amazing cookbook and the release! We love biscoff and I am SO excited there is a whole book with recipes for it 🙂
Thanks Chelsea that means so much!
[email protected]+Crunchy+Creamy+Sweet — November 3, 2014 at 8:00 am
Congratulations! SO happy for you! Can’t wait to get my copy!
Thanks Anna!
Joyce T. — November 3, 2014 at 8:01 am
The pictures from the book look DELICIOUS!! I love Biscoff. I scour Big Lots, the commissary German section, and even brought back a CASE from my last trip to Europe. I love, love, love them.
Telza — November 3, 2014 at 8:17 am
Congratulations! It looks like a great cookbook filled with deliciousness and lovely pics!
Mara — November 3, 2014 at 8:23 am
Congratulations…Perfect time of year to release a cookbook, right in time for holiday baking!
Katrina — November 3, 2014 at 8:26 am
I love biscoff! The second I heard you were doing a biscoff cookbook I knew I must have a copy. Those brownies and the buckeye cake look amazingly delish! I am now sad my morning can’t start out with a heaping spoonful of biscoff!
Thank you so much! I hope you love it as much as I do!
Sarah W. — November 3, 2014 at 8:42 am
This is fantastic. I’m slightly obsessed with biscoff 🙂
Linda — November 3, 2014 at 8:44 am
Can’t wait to try some of these recipes – they look delicious!
Debbie Garen — November 3, 2014 at 8:49 am
Congrats on the book! Everything looks so yummy!! Can’t wait to get!
Erin+|+The+Law+Student's+Wife — November 3, 2014 at 8:50 am
CONGRATS KATRINA!!!! So so so happy for you xoxoxo
Thank you Erin!!
Alyson Myers — November 3, 2014 at 8:53 am
Congratulations!! Can’t wait to try out some recipes!
Amy @Very Culinary — November 3, 2014 at 9:04 am
Yep, you’re the one who introduced me to this stuff. Life changing! Super congrats on the book – so excited for you!
You have been so supportive from the start. Thank you my sweet friend!
Cynthia — November 3, 2014 at 9:10 am
Congratulations ! Everything looks delicious ~
Gina Florencia — November 3, 2014 at 9:11 am
Can’t wait to see the book! Thanks…Gina F
Diane Riedel — November 3, 2014 at 9:13 am
Congratulations my dear!! I’ll be looking for your cookbook, I would love to get my hands on your lovely recipes.
Julie Cooney — November 3, 2014 at 9:14 am
Love Biscoff! Can’t wait to get my hands on your book!
Meg Hobbs — November 3, 2014 at 9:17 am
A cookbook with Biscoff recipes would be great, assuming my Charlie doesn’t find a spoon and the jar first…
Sonya Rogers — November 3, 2014 at 9:20 am
Love your blog, have made a lot of your recipes and love them all .Biscoff is one of my favorite things, remember the first time I had a cookie o a plane trip.So happy we now have the spread ! And your recipes !
Thank you Sonya. That means so much to me!
Adrienne — November 3, 2014 at 9:22 am
Congrats on the cookbook. The food looks wonderful.
Beth — November 3, 2014 at 9:23 am
Looks beautiful and sounds mouth-watering! Can’t wait to check it out. Congratulations!
Audrey wolff — November 3, 2014 at 9:24 am
I am so so excited about your new cookbook. It is at the top of my XMas list but I might not be able to wait that long!!! This is bond to be a best seller for sure! Congratulations!
Heather Brown — November 3, 2014 at 9:24 am
Love Biscoff and would love an entire cookbook dedicated to it 🙂
Amy C. — November 3, 2014 at 9:27 am
Congrats on your new cookbook! I love Biscoff spread and have made a couple of recipes with it. It would be great to have a whole book full of ideas!
Rebecca Wasko — November 3, 2014 at 9:27 am
So excited for you! Can’t wait to get a copy!
Jen bland — November 3, 2014 at 9:38 am
yeah, so excited about your cookbook. I have been a huge bis off lover for years!!!
Jennifer — November 3, 2014 at 9:39 am
Everything pictured looks so yummy. I can’t wait try the Biscoff Spread
and recipes from the cookbook.
Jessie Voigts — November 3, 2014 at 9:47 am
Congratulations!! I love Biscoff – your cookbook will be amazing!
Heather Post — November 3, 2014 at 9:50 am
Can NOT wait to get this book! Biscoff and I are best buds already…. Yummity yum yum!
Stephanie — November 3, 2014 at 9:50 am
Congratulations on your book! Anyone who can create a whole book with Biscoff recipes is my hero! I can’t wait to get my hands on this book!
Brenda — November 3, 2014 at 9:51 am
These look so yummy.
Sue {munchkin munchies} — November 3, 2014 at 9:52 am
I am so happy for you, Katrina! I have the book and LOVE it! XO!
Thanks Sue! And thanks for getting your own copy too! xoxo
Pam — November 3, 2014 at 9:53 am
JoeyfromSC — November 3, 2014 at 10:04 am
oh my goodness…it all looks amazingly delicious lol
Thank you SO much for the chance to win!! Congrats on your book also!!
Joey J.
Fiona Young-Brown — November 3, 2014 at 10:04 am
My husband has been a Biscoff freak for years, probably because he flies so much for work. There is something about them. Best of luck with the book!
Patty Jensen — November 3, 2014 at 10:05 am
so, so happy for you! What an amazing dream/goal you’ve realized. Not sure what I want to win more……………your book or the spread!! Delicious!
TB — November 3, 2014 at 10:05 am
Congratulations! I can’t wait to receive this new book!
Karen D. — November 3, 2014 at 10:08 am
I am so excited to check this out. I was recently introduced to the glory of Biscoff spread and my son will sit and eat half the jar with a spoon. We love Biscoff!!
Leesa — November 3, 2014 at 10:09 am
Oohhhh, I LOVE Biscoff cookies – wicked awesome to have a cookbook dedicated to all things Biscoff.
StaceyL — November 3, 2014 at 10:21 am
Omg, this totally makes my Monday! There is now entire cookbook dedicated to this delicious stuff? Day made!
Kody — November 3, 2014 at 10:22 am
I LOVE Biscoff cookies
Kristin — November 3, 2014 at 10:23 am
I love biscoff and these recipes look amazing
Gloria R. — November 3, 2014 at 10:31 am
Congratulations on your new Biscoff Cookie and Spread cookbook. Everything sounds so delicious and certainly would make a great holiday gift. 🙂
It;s the perfect book for this time of the year.
Patricia B — November 3, 2014 at 10:34 am
Congrats!!! I am eager to get my hands on a copy!!
nicole @ I am a Honey Bee — November 3, 2014 at 10:43 am
i’m so excited for you! It’s such a great accomplishment. You shoud be so proud of yourself. Those brownies look yummy!
Kelly — November 3, 2014 at 10:52 am
Carrie N — November 3, 2014 at 10:57 am
Congrats! I’ve never tried the spread before but now i certainly do!
Kitti Boesel — November 3, 2014 at 11:00 am
OMG! We LOVE LOVE LOVE Biscoff! Whether I win or not (which I hope I do), we will totally be getting this cookbook!!!! Just in time for the holiday baking season too! WOOHOO!!!
Jacqui — November 3, 2014 at 11:11 am
I LOVE Biscoff and this cookbook is genius!! Would love to win!
Lauren — November 3, 2014 at 11:26 am
Those biscoff banana streussel muffins look heavenly! I have to try them! Congrats on the book! 🙂
barbara quinn — November 3, 2014 at 11:26 am
Congrats on your cookbook. I can’t wait to get a copy of your cookbook. I use Biscoff spread in so many of my baking recipes and am anxious to get more
Ashley — November 3, 2014 at 11:38 am
The book looks amazing! Congratulations on your success! Can’t wait to try all the recipes!
Nicole — November 3, 2014 at 11:40 am
Congrats! Huge accomplishment. I’m a bit of a Biscoff addict. Great giveaway.
Joy Saunders — November 3, 2014 at 11:40 am
Mazel Tov Katrina! What a phenomenal accomplishment and I’m so happy for you! Wishing you all the success with the book (can’t wait to add it to my collection).
Gayle215 — November 3, 2014 at 11:42 am
Congratulations on this monumental accomplishment! I would love to win this prize!
Ali | Gimme Some Oven — November 3, 2014 at 11:44 am
So exciting! Congratulations!! Can’t wait to see it. 🙂
Thanks Ali! Can’t wait for YOURS 🙂
Gigi lange — November 3, 2014 at 11:47 am
Love Bischoff!! My daughter introduced me to it last year!! Best thing ever..
susan — November 3, 2014 at 11:57 am
This will be a Christmas gift for my daughter who has been making biscoff balls at every family gathering. She will flip if she gets this!!!!!!!
lorene holbrook — November 3, 2014 at 12:00 pm
oh my gosh!!!! I so need this!!! everything looks sooooo yummy! thanks for the chance!
Kelly McMillan — November 3, 2014 at 12:16 pm
The book looks amazing!
MaryEllen — November 3, 2014 at 12:17 pm
Great giveaway!! My family LOVES Biscoff Spread!!
Danielle knight — November 3, 2014 at 12:21 pm
finally a cookbook for the Biscoff Spread. Both smooth and crunchy taste amazing! Hopefully I can win a signed cookbook and get to using it asap!!
Dana — November 3, 2014 at 12:37 pm
I love Biscoff, but have always been puzzled by ways to use it. This book would solve that issue for me. Thanks for the giveaway.
Sue Powell — November 3, 2014 at 12:39 pm
So pleased that a local grocery finally started selling Biscoff spread! I love eating it on apple slices and have made some yummy cookies with it. Look forward to trying many of your recipes as well.
LauriM — November 3, 2014 at 12:52 pm
I am so excited or this giveaway. I’ve already ordered your book, but it would be great to win a signed copy, plus…Biscoff!!!
Farhana Sarker — November 3, 2014 at 12:55 pm
OMG! your book looks AMAZING! I hope I win 😀
Jennifer — November 3, 2014 at 12:56 pm
I’m so excited about this cookbook. I love Biscoff and am always looking for recipes that use it!!!
Barbara — November 3, 2014 at 1:18 pm
Oh YUM! This is a must have. Oh no….need a spoonful of Biscoff after reading all this upcoming delishisness….
Nancy Rogers — November 3, 2014 at 1:23 pm
Congratulations on your Biscoff cookbook! Thank goodness, Biscoff cookies and spread are so readily available in So. Cal =). Love your website.
Sharon S — November 3, 2014 at 1:30 pm
Woohoo! Congrats on the cookbook and thanks for the giveaway
MassachusEATS — November 3, 2014 at 1:32 pm
Obsessed with this stuff – cannot wait to check the book out!! 🙂
mary e. — November 3, 2014 at 2:03 pm
i wish you all the best and hope your book sales exceed your expectations!
i have your book on my wish list on amazon..your recipes look soo yummy
and can’t wait to have a copy.
Elaine Hodges — November 3, 2014 at 2:31 pm
Love the spread! If I win a case I will actually use some of it in recipes instead of eating it straight out of the jar!
Heather — November 3, 2014 at 2:45 pm
How exciting!! I can’t wait to check this cookbook out!! Yummo!!
Deb|EastofEdenCooking — November 3, 2014 at 3:30 pm
What an exciting time! Wishing you scoops of success with this fantastic book.
I would love to try the White Chocolate Biscoff cookies!
CM — November 3, 2014 at 3:56 pm
Can’t wait, love Biscoff
Jennifer Appleton — November 3, 2014 at 4:19 pm
This is great! I’m allergic to peanuts and tree nuts, so I can’t eat peanut butter, almond butter, cashew butter, etc… This is such a great substitute for baking!
Rachel — November 3, 2014 at 4:54 pm
Congratulations! The book looks beautiful!
Maria Poulimenos — November 3, 2014 at 5:08 pm
Wow all looks amazing, adding Biscoff in to cupcakes and brownies sounds yummm #drooling
Angelia Howard — November 3, 2014 at 5:21 pm
Wonderful gift idea for a friend who loves Biscoff! can’t wait to try some of the recipes for her!
Lauren G. — November 3, 2014 at 6:01 pm
Yum! Love Biscoff cookie butter. It’s so good even out of the jar.
Sherry Gore — November 3, 2014 at 6:06 pm
Congratulations on the launch of your first cookbook! It’s a very exciting time. I envision great future for you. 🙂
Brenda — November 3, 2014 at 6:52 pm
oh, how exciting…I love Biscoff spread…looks like some great recipes.
Stephanie — November 3, 2014 at 8:16 pm
YAY! Congrats to you!!! I want to devour that cupcake on the front!
Kristin Thomas — November 3, 2014 at 8:27 pm
OMG! I absolutely LOVE Biscoff in any way shape or form! NUM!! Hope I win!
Isabel — November 3, 2014 at 9:19 pm
This book will be the perfect gift for my kids who love to bake and also love Biscoff. And for myself, too, of course!
Amy — November 3, 2014 at 10:33 pm
I love biscoff! Its so hard to get in Melbourne but I always manage to somehow find it on random sites online (so expensive though). I need your book like, right now!
Alison — November 3, 2014 at 11:29 pm
Our family loves biscoff spread. We are a nut free family and when we found that the biscoff was nut safe I had the realization that buckeyes could once again be a christmas tradition.
keith malcuit — November 4, 2014 at 12:15 am
I hope to win! I love this biscoff! Gosh, a recipe book and a case of the stuff, how can you go wrong!
Katie Spice — November 4, 2014 at 12:55 am
Such a fun book!
Walda — November 4, 2014 at 3:48 am
I never heard of Biscoff but after reading all these comments, I’m headed to the store tomorrow to buy some.
I left a comment earlier this morning but it isn’t showing up! I said that I have never heard of biscoff, but after reading all, the comments about it, I am going to buy some tomorrow when I go shopping. I love your website, I think I must have gained a couple of pounds just looking at all the goodies you have here. I am definitely going to try some of them, my sweet tooth is all fired up just looking at some of these recipes. Thanks for a great site!
Ellie Prax — November 4, 2014 at 8:13 am
Oh my goodness I need to win!!!! I love Biscoff and I need a new cookbook for college!!
Kelly — November 4, 2014 at 8:21 am
Can’t wait for the ideas, pictures, and inspiration!
Sheri Riemenschneider — November 4, 2014 at 8:54 am
Wow…you mean there are other ways to eat Biscoff other than on a spoon?
Chris Bennett — November 4, 2014 at 9:20 am
Thanks for the give away – you new book will provide me with some new recipes for holiday desserts..!!!
Linda Garcia — November 4, 2014 at 10:40 am
Love Biscoff! Can’t wait to try some recipes!!
Jenn L @ Peas and Crayons — November 4, 2014 at 11:23 am
I can’t wait to get my hands on your book! Congrats x100000!
Tiffany — November 4, 2014 at 12:15 pm
Thanks so much for the givaway!!
Diane Hunsicker — November 4, 2014 at 12:28 pm
Katrina this cookbook sounds awesome. Can’t wait to see it.
Brandy Y. — November 4, 2014 at 1:16 pm
I love baking with Biscoff so this would be great!
Rose @ RoseBakes.com — November 4, 2014 at 1:24 pm
I cannot WAIT to try some of these recipes!!
Kimberly — November 4, 2014 at 1:50 pm
Your desserts look amazing! I can’t wait to start cooking!
Megan Z — November 4, 2014 at 2:50 pm
I am so excited to try some of these recipes with my new kitchenaide mixer! They all sound amazing!
Alison — November 4, 2014 at 5:16 pm
I’ve heard a lot about Biscoff, but never tried it Excited to see what all the fuss is about!
mollie — November 4, 2014 at 6:42 pm
OMG! I love biscoff!!!
Opal Baker — November 4, 2014 at 6:48 pm
I think that I gained ten pounds just looking at your page.Wow,they make my stomach growl.
Karen — November 4, 2014 at 7:44 pm
Congratulations on your book:)
Sharon+S — November 4, 2014 at 7:49 pm
Your book sounds wonderful!
Cassie — November 4, 2014 at 9:01 pm
I would love to win this book! It looks amazing and I LOVE Biscoff!!!
Tracy — November 4, 2014 at 9:13 pm
Congratulations! I rue the day I ever tried Biscoff spread. I’m sure your book would entice me to do something with it other than stick a spoon in the jar….
Tami Dalcolma — November 4, 2014 at 9:38 pm
i plan to make those swirl fudge bars. I haven’t seen these cookies in our stores in SC. I’ve only had them on Air Transport flights. I usually ask for more!
Carol — November 4, 2014 at 10:04 pm
Congratulations on your cookbook, Katrina! Oh boy do I love Biscoff……and I love baking with it.
Deb Berg — November 4, 2014 at 10:12 pm
One can never have too many ways to use Biscoff!
Rebecca — November 4, 2014 at 10:34 pm
This book looks amazing! And who wouldn’t want a CASE of Biscoff? Yum!
Cheryl Rahkonen — November 5, 2014 at 12:11 am
All the recipes look so delicious, especially the Fudgy Biscoff Swirl Brownies. I would love to try them all. I have never tried the spread but after looking at these recipes, I know that I have to get some of this.
Susan P. — November 5, 2014 at 1:30 am
I would need your cookbook if I won a case of Biscoff spread!
Laura Isabell — November 5, 2014 at 4:21 am
All these recipes look sooo good, I’ll definitely have to try them!
Patricia Caradonna — November 5, 2014 at 5:17 am
The cookbook and spread sound perfect for the holidays.
[email protected] — November 5, 2014 at 8:18 am
A huge congrats, Katrina! This book looks magical. You are one talented gal.
Sherri S. — November 5, 2014 at 11:32 am
Oh my, this looks heavenly! I would love to have this cookbook!
Janet — November 5, 2014 at 1:47 pm
Congratularions on your book!! It looks yummy and I would love to try all the recipes!!
Mary W — November 5, 2014 at 2:02 pm
I have family members who would go bonkers for a jar of Biscoff spread. I see instant stocking stuffers!
Michelle @ My California Kitchen — November 5, 2014 at 2:44 pm
This book looks amazing! Biscoff is my life!
Deana Paul — November 5, 2014 at 3:13 pm
I just discovered Biscoff spread. It is amazing. I love making peanut butter balls with it. Can’t wait for the cookbook!
Kim Henrichs — November 5, 2014 at 8:25 pm
Congrats!! What an absolutely amazing looking cookbook!!!!
Pam — November 5, 2014 at 8:45 pm
i would love to add this cookbook to my collection
Karen+Lynch — November 5, 2014 at 11:36 pm
This could be a dangerous book to have. Congratulations.
Ashley | Our Full Table — November 6, 2014 at 11:15 am
This looks risky! I will want to bake everything!! *SWOON*
KATE — November 6, 2014 at 3:37 pm
Congrats Katrina! This is awesome!
Jackie — November 6, 2014 at 5:00 pm
OMG this looks heavenly! I would love to have this cookbook!
Katrina Hedgpeth — November 6, 2014 at 8:22 pm
i am also Katrina! Your stuff looks wonderful! Especially the cheesecake!
Shae — November 6, 2014 at 9:53 pm
Yay, looks great.
sarah k — November 6, 2014 at 11:30 pm
Congrats on your book, my mouth is watering just looking at the pictures. I’ve just recently tried Biscoff and can’t believe it took me so long to try it, I’m looking forward to trying it in different recipes.
Connie — November 7, 2014 at 7:34 am
My kids love this stuff – since my daughter is milk/nut allergic it has been our peanut butter/nutella replacement. I saw a link to your site from http://www.sallysbakingaddiction.com. Thanks for making a book with great looking recipes!
Sophie — November 7, 2014 at 8:13 am
As a native belgian I was so excited when the spread made it across the pond and I am as excited about this cookbook. Thanks for the chance.
Michelle @ Modern Acupuncture — November 7, 2014 at 8:53 am
This book! Seriously, I am so glad I stumbled across this website and found your book! It’s so pretty and the treats… divine. I have always been a closet Biscoff fanatic, but now I see I don’t have hide the love anymore! I’m among my people, finally. Not to be creepy, Katrina, but I think I love you.
This totally made my day 🙂 “I’m among my people!” lol yes you are!!
Kim — November 7, 2014 at 11:50 am
yum, this cookbook looks awesome!
Brenda D — November 7, 2014 at 11:19 pm
Renne Muhlmichl — November 8, 2014 at 8:35 am
Your book looks amazing! Can’t wait to get one! I love your recipes as well! Thanks for sharing!
Debbie Williams — November 8, 2014 at 9:58 am
Biscoff is the best. I first found them while traveling through Europe. I would love to have a cookbook that uses them!
Anna Papperman — November 8, 2014 at 11:13 am
Excited for the cookbook!
PAT HUNSICKER — November 8, 2014 at 11:55 am
CANT WAIT TO GET THE COOKBOOK! CONGRATS Katrina!
Sherrie Taylor — November 8, 2014 at 12:16 pm
I can’t wait to get this cookbook! What a fabulous way to CELEBRATE ️Biscoff!!
Nikki — November 8, 2014 at 1:18 pm
congrats, the book looks amazing!
Barb — November 8, 2014 at 1:27 pm
This is so awesome would love to win the cookbook
Jessica — November 8, 2014 at 2:55 pm
Congrats!! Would love to try out these recipes!!!
Erica I — November 8, 2014 at 8:52 pm
This is probably the best cookbook idea I’ve ever heard of! I love Biscoff so much, it’s hard to explain to people most of the time how good it tastes.
Sharon knitter — November 8, 2014 at 8:56 pm
Can’t wait to try so many recipes
Linda Meyers-Gabbard — November 9, 2014 at 6:20 am
Congratulations on the cookbook. Oh my I have gained 10 lbs just looking at the pictures. The Buckeye Cake looks amazing. I’m from Ohio and The Buckeye is our state tree, we have the
OSU Buckeye Football Team and the Buckeye candies are a staple at Christmas time. If I am not the lucky winner, I’m going to ask Santa for a copy of your cookbook so I can make that delicious looking cake along with your other yummy creations. THANK YOU for the opportunity.
Jamie — November 9, 2014 at 11:35 am
Anna — November 9, 2014 at 5:30 pm
Oh wow — that cookbook looks *amazing*! I love Biscoff!
Congrats, girl! This book is amazing!
Michelle Wright — November 9, 2014 at 6:20 pm
Congrats on the cookbook! Everything looks so good!!!
Katrina Farmer — November 9, 2014 at 7:21 pm
Congrats on the cookbook! I know this is a dream come true for you.
Jane Mi Harper — November 9, 2014 at 8:11 pm
Yummy! Congratulations on the book!
Debbie Hutchison — November 9, 2014 at 8:15 pm
Ooh I love Biscoff! I’d love to get your book! 🙂
Denise Danca — November 9, 2014 at 8:27 pm
I cannot wait to get this cookbook! I was just very recently introduced to Biscoff spread by my daughter who was home visiting from college. SO addicting!
Lorraine Pawelec — November 9, 2014 at 8:51 pm
Congratulations! Would love to win!
Carmen N — November 9, 2014 at 10:35 pm
wendy b — November 10, 2014 at 12:30 am
Yum Yum Yum is all I can say!!
Ali painter — November 10, 2014 at 12:33 am
Oh my gosh pick me!!!!! This would be awesome for my hubby!!!!!!
Jennifer McGraw — November 10, 2014 at 1:08 am
Your recipes look amazing! I’ve been wanting to try a recipe using biscoff spread but have not yet had the chsnce. Congrats on your cookbook a ND wish you continued success.
Kelly G — November 10, 2014 at 6:21 am
Can’t wait to check out the cookbook!
Debbie D — November 10, 2014 at 8:18 am
Congats… just recently introduced to Biscoff… so happy to see your book!!
Marielia — November 10, 2014 at 8:40 am
amazing idea for a cookbook!! Congratulations!!!
Kathy Summers — November 10, 2014 at 9:58 am
I look forward to seeing this cook book and following your posts and recipes, yummmmmmoooo
Deanne Lybarger — November 10, 2014 at 11:25 am
Congratulations Katrina !!!!
Cant wait to get your cookbook and try some new recipes.
So proud of you !!!
lesley — November 10, 2014 at 11:33 am
this sounds awesome – thanks for the giveaway!
Amanda — November 10, 2014 at 12:20 pm
YUM! Thanks.
Helen — November 10, 2014 at 3:27 pm
Can’t wait to try some recipes!
T. Toon — November 10, 2014 at 5:38 pm
Omg I love Biscoff! The spread alone is so good. Yes I’m talking straight out the jar, don’t judge!
Susan R — November 10, 2014 at 5:58 pm
I am SO intrigued by the photos of these desserts! I have not tried Biscoff products, but I really want to now that I have seen your new book! Eat dessert first!
Katherine — November 10, 2014 at 7:27 pm
I absolutely love Biscoff spread, that’s such a great idea! I know what to ask for for the Holidays, sounds awesome!
Jeffrey — November 10, 2014 at 7:50 pm
My whole family loves Biscoff, especially my youngest. He packs it in his lunch everyday.
Yesenia Salgado — November 10, 2014 at 8:19 pm
These look Oh SO YUMMY!!
Angela {Mind Over Batter} — November 10, 2014 at 9:36 pm
I um… I’ve never had biscoff, so I totally need to make up for lost time.
alicia Pitts — November 10, 2014 at 9:53 pm
Congratulations on your book! I have never tried biscoff before, so I would love to win!!! Congrats again!
CassandraD — November 10, 2014 at 10:18 pm
Biscoff is great.
Sandy Headtke — November 10, 2014 at 10:28 pm
You mean to tell me there is another way to eat this than a spoon out of the jar? Maybe if I win a case there will be enough to use after dveryone claims their own jar
Sarah @ SnixyKitchen — November 11, 2014 at 1:26 am
Congratulations on your book launch Katrina! It looks great!! Bravo!
linda jones — November 14, 2014 at 5:46 pm
The book looks so inviting ! Congragulations for such a wonderful book.It looks beautiful as well as helpful.
Tracy Spangler — November 19, 2014 at 11:42 pm
I am a happy, happy woman today! I’ve dedicated a post on my blog for my great love of Biscoff Cookie Butter, but now I have found your site and your entire cookbook dedicated to the most delicious food ever made! It’s more than a spread-it’s heaven on a spoon! I am thrilled that I can graduate from Biscoff on graham crackers, apples or straight off the spoon, and use your recipes to make amazingly delicious creations! I worried for a brief hour or so about my new found addiction to Biscoff, and the scale certainly shows the result of such love, but it’s the holiday season, so I’ll worry about the weight when making New Year’s resolutions! Thank you for your amazing recipes!
Oops- my apologies- now I see your recipes are not all Biscoff based, but your cookbook is! Your recipes look so yummy! Congratulations and thank you for your amazing cookbook!
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"I loved the week I spent at iD Tech! I met new friends that were very kind. The instructors were energetic and involved with what I was doing. I know for sure that I'll come back again next year!"
Henry M., Benedictine University
"This was one of the greatest camps I have ever been to. I hope other people will bring their kids here so they can learn, make friends, play games, and have a blast."
STEM Programs in Chicago
Check out iD Tech held at GEMS for more course and date options.
Coding Games in C++
Take C++ to the next level by implementing imagery in your games!
STEM Competitions & Events
No matter your interest, there are a number of ways to compete. STEM is no different!
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Legend of Zelda: Wind Waker
CESA Announces Game Awards
Zelda given award for excellence.
By IGN Staff
Updated: 16 Jun 2012 9:24 pm
Posted: 30 Oct 2003 4:41 pm
Japan's Consumer Entertainment Software Association (CESA) has announced the year 2002-2003 results for its yearly videogame awards presentation, representing software released between January of 2002 and March 31 of 2003. The CESA awards are chosen by a panel of judges taking into consideration votes from game players and the suggestions of industry insiders including magazine editors and game creators.
For the first time in the seven year history of the awards, two games have taken top honors for excellence. CESA awarded its grand prize to both Final Fantasy XI (Square-Enix, PS2/PC) and Taiko no Tatsujin (Namco, PS2). The latter title, while still not available in America, has proven to be a sensation in Japan, with non-stop arcade play and two PS2 versions combining for sales of over a million units.
Following these two, numerous titles were given mention in the CESA's award for excellence category. The winners are:
Final Fantasy X-2 (Square Enix, PS2)
Dynasty Warriors 2 (Koei, PS2)
World Soccer Winning Eleven 6 (Konami, PS2)
.hack -- the series (Bandai, PS2)
Legend of Zelda: The Wind Waker (Nintendo, GCN)
Tekki (Capcom, Xbox)
Halo (Microsoft, Xbox)
Pokemon Ruby/Saphire (Nintendo, GBA)
Made in Wario (Nintendo, GBA)
The CESA also gave out numerous awards in a few specific fields.
Best Seller Award
Global Award (for overseas developed games)
Grand Theft Auto III (Rockstar, PS2)
Global Award (for domestically developed games)
Kingdom Hearts (Square Enix, PS2)
Anubis: Zone of the Enders (Konami, PS2)
Game Awards Future (for future "cool" titles)
Gundam Z (Bandai, PS2)
Metal Gear Solid 3: Snake Eater (Konami, PS2)
Gran Turismo 4 (SCEJ, PS2)
Onimusha 3 (Capcom, PS2)
Naruto: Narutimate Hero (Bandai, PS2)
Monster Hunter (Capcom, PS2)
Eye Toy Play (SCEJ, PS2)
Katamari Damashii (Namco, PS2)
Siren (SCEJ, PS2)
True Fantasy Live Online (Microsoft, Xbox)
Gyakuten Saiban 3 (Capcom, GBA)
Half Life 2 (Valve, PC)
This marks the second year in a row that a Final Fantasy game has taken top honors from the CESA. Last year, Final Fantasy X ended up at the top.
It's unclear if being honored by the CESA will get you a free mention in Gran Turismo 4
Rated "E"
Release DateMarch 25, 2003
PlatformsGameCube
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GovernanceLand acquisitions and rightsLaw
Legal tools for citizen empowerment
LandCam: securing land and resource rights and improving governance in Cameroon
February 2017 to December 2021
Cameroon is revising its land and natural resource laws. This project supports this effort by piloting approaches on the ground and helping citizens participate in the reform process.
Large land areas in Cameroon are held under agribusiness and logging concessions. While private sector investments hold out promise for green growth and poverty reduction, the country faces governance challenges, including a legal system in flux and weak regulation.
In 2008, the government launched a series of reforms in the natural resources sector to update land, forest, mining and environment laws. But the process has been too sectoral, both among ministries and non-governmental bodies.
Meanwhile, land under customary tenure (some 85 per cent of Cameroon's land) is becoming increasingly insecure. Investors are seeking extensive areas for developing concessions. Mining, forestry and agribusiness concessions overlap with one another and with protected areas and community lands, leading to conflict.
A major coordination effort is needed to ensure that the voices of all stakeholders are heard in the reform process, and that all stakeholders are well informed of both the reality on the ground and of good practice in securing rights and improving governance.
Update: LandCam enters a new phase
Over five years, from February 2017 to December 2021, the LandCam project will work with key stakeholders across Cameroon to negotiate rights to land and natural resources through demonstrable good governance and workable reforms of the relevant laws. We will work to create new spaces for more informed, effective and inclusive dialogue and analysis, engaging the public and media, as well as civil society platforms. And we will monitor changes on the ground, track legal reforms, and share lessons nationally and internationally.
From 2018-20, LandCam will focus its efforts at the grassroots level. Working directly with local civil society organisations and community groups, LandCam is launching a series of bottom-up interventions to clarify legitimate land tenure rights in three different districts and through a small grants scheme.
In the three project sites, rural land is still primarily managed according to diverse customs, yet people often lack legal recognition and protection of their land rights. In a context of growing land pressures due to diverse factors including population growth, migration, large-scale infrastructure development and the expansion of agro-industrial plantations, promoting local-level dialogue and dispute resolution around conflicting land claims is more urgent than ever.
In the three sites, LandCam will also collect in a participatory manner important land-use data. This data will directly feed local dialogue processes in order for local stakeholders to take informed decisions about land-use governance and planning. The team is currently fine-tuning the methodology for data collection. This will be published, together with the findings, in LandCam’s annual Land Governance Tracking report. Stay tuned for more details.
To strengthen capacity and pilot approaches in selected sites that enable stakeholder voices to be heard and rights to be secured
To create spaces for more informed, effective and inclusive dialogue on designing and implementing reforms, and
To track land and natural resource governance, including legal reforms, and share lessons nationally and internationally.
What will IIED do?
IIED is ensuring overall project coordination, working closely with partners in Cameroon and internationally. We are also providing technical support, and are documenting and sharing experience, and overseeing evaluation.
Brendan Schwartz, Senior researcher, Natural Resources research group
A collaborative initiative to strengthen local rights and voices
Land rights: the missing link for food security in Cameroon, Jaff Bamenjo, Sandrine Kouba, Brendan Schwartz (2019), IIED Briefing | en français
Apes, crops and communities: land concessions and conservation in Cameroon, Michelle Sonkoue, Samuel Nguiffo (2019) IIED Briefing | en français
Towards fair and effective legislation on compulsory land acquisition in Cameroon, Brendan Schwartz, Lorenzo Cotula, Samuel Nguiffo, Jaff Bamenjo, Sandrine Kouba and Teclaire Same (2017), IIED Briefing | en français
Indigenous peoples' land rights in Cameroon: progress to date and possible futures, Samuel Nguiffo, Victor Amougou Amougou, Brendan Schwartz, Lorenzo Cotula (2017), IIED Briefing | en français
LandCam project website
This project was produced with the financial support of the European Union. Its contents are the sole responsibility of IIED, CED and RELUFA, and do not necessarily reflect the views of the European Union.
Centre for Environment and Development (CED)
Réseau de lutte contre la faim (RELUFA)
Locally controlled forestry
Customary laws
Legal activism key to securing land rights in new investment phase
Blog, March 2018
Improving the use of legal tools to strengthen local rights and voices in natural resource investments. More in this collection
Introduction to legal tools for citizen empowerment
Assisting communities to seek legal redress for land rights violations
Making their voices count
Development finance and land rights: how we can do better
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Investigation Protects Employees and Prevents a Major Bad Decision in a Small Business
TSCM
One thing we know here at International Investigators, is that when getting to the truth is a matter of importance, you have to call in professionals – and the sooner the better.
Dina’s attorney wasted no time in referring the solopreneur to a professional investigator. In the initial meeting she explained the situation:
She had been a solopreneur in her accounting firm for almost five years. Her firm was growing and she started to entertain the idea of adding a partner. When Brett walked through the door looking for a job, it was like he was tailor-made to fit right in with the firm and clientele she had targeted. He was smart, technically proficient, and charming. She hired him on the spot during his first interview.
After several months and pretty fast growth, Dina decided to expand and hire an office manager to help manage the growth. Brett suggested his mother, who had just recently retired from a full-time career and just wanted something to keep her busy. Just like Brett, Martha was perfect and fit right in.
The business was growing and both Dina and clients were happy. The staff was close and often socialized together. One day, Allie, one of the junior accountants, asked to talk with Dina privately.
During the conversation, Allie said that during an evening out with the group, Brett has given her a drug and tried to take advantage of her sexually. Dina could hardly believe it, but she thanked Allie for her courage and candor and told her she would keep her confidence and investigate. As soon as Allie left the office, Dina called her attorney. The attorney immediately referred her to investigators.
The kind of behavior that Brett allegedly presented is most commonly a habitual pattern, not a one-time event. Investigations today are more than following someone and taking pictures. They can be complex and often are multi-pronged. In this case, there were four aspects:
Immediately a plan was developed for covert surveillance. Because the accusation tinged on criminal activity, investigators were sure to use surveillance equipment and collect evidence following evidence collection protocols. If needed in court, the evidence would be admissible.
Brett’s office computer was brought in for a computer forensic examination. Because it belonged to the firm, Dina was able to provide permission for the computer forensic analysis. Again, professional protocols were used along with data mining software to get the best results during the forensic computer investigation.
The third leg of the investigation was to learn as much as possible about Brett’s past. Dina was beating herself up for not conducting due diligence on him as she normally would have in the past. Employment background checks are always a good idea, especially when you consider making someone a partner.
To find out more about Brett, a background investigation, including a criminal background search was started. In addition, investigators began an online investigation, connecting with Brett through social media.
Information was building up on Brett and then Dina got a request to talk privately from another employee, Anna. The story she told was similar. The one thing Dina was grateful for was that both girls had been able to ward off his advances. But it made her wonder if the other two female employees had been approached as well.
The outcome made possible by the investigation
With sufficient evidence to support the girl’s claims, Dina and her attorney confronted Brett. At first he denied it, but then faced with the evidence, he admitted his actions. He agreed to resign. At first, his mother didn’t believe the facts of the situation, but once he confessed and shared the evidence, she had no alternative but to believe him, and also resign.
Because Dina had evidence and facts at her side when she confronted him, there was no option but for him to confess. Dina and her attorney had prevented a he said/she said situation proactively.
In the end, Dina’s employees were grateful for the openness Dina exhibited in believing them and the action she took to prevent it from happening again, protecting them in their workplace and even in part of their social life.
Dina said she learned to vet every potential hire thoroughly. She realizes that there may always be facts hidden, but she knew she would have experts conducting the background checks and her due diligence would illuminate potential red flags.
Whenever you, and your business, are in a situation where facts and evidence are critical, hire professionals who will know how to get to the truth of the matter. Make International Investigators your first call!
-T. Wilcox, CEO, International Investigators
-B. McGinley, Director of Operations, International Investigators
January 12th, 2016|Computer Forensics, digital forensics, Private Investigations, Social Media, TSCM|Tags: computer forensic analysis, computer forensics, Computer forensics experts, covert surveillance
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Naftaly Githaka
Scientist & Tick Unit Manager
Dr Naftaly Githaka joined ILRI as a support officer for the tick unit on 20 January, 2014. Naftaly previously worked with ILRI for seven years (2002-2009) as a research technologist for the vector genomic project where he contributed towards identification and characterization of candidate anti-tick vaccine antigens. Naftaly holds a PhD in veterinary medicine (2013) from Hokkaido University in Japan, a Master’s degree in molecular parasitology from Jomo Kenyatta University of Agriculture and Technology (2008) and a Bachelor’s qualification in biochemistry and chemistry from the University of Nairobi(2002). Naftaly’s PhD studies focused on the molecular characterization of tick-borne haemoparaistes at the livestock-wildlife interface in Kenya and evaluation of a recently identified anti-tick vaccine antigen against important tick vectors found in Japan. Naftaly has authored and co-authored 16 publications in international peer-reviewed journals with several others under review. His role with ILRI will be to support on-going research projects on tick-borne diseases and to bring on board local and international collaborators to enhance the utilization of the tick unit.
My CRPs
Pig value chain and African swine fever mitigation: A call to rally cross-program collaboration
value chains
A comprehensive survey of the prevalence and spatial distribution of ticks infesting cattle in different agro-ecological zones of Cameroon
In silico characterization and structural modeling of Dermacentor andersoni p36 immunosuppressive protein
Effect of recombinant glutathione S-transferase as vaccine antigen against Rhipicephalus appendiculatus and Rhipicephalus sanguineus infestation
Expression profile of Rhipicephalus microplus vitellogenin receptor during oogenesis
Preliminary efficacy investigations of oral fipronil against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions
Identification and the preliminary in vitro characterization of IRIS homologue from salivary glands of Ixodes persulcatus Schulze
Evaluation of a topical formulation of eprinomectin against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions
An investigation of binding ability of Ixodes persulcatus Schulze Salp15 with Lyme disease spirochetes
Non-classical gluconeogenesis-dependent glucose metabolism in Rhipicephalus microplus embryonic cell line BME26
ILRI Tick Unit: Local research with global impact
A novel mechanism of functional cooperativity regulation by thiol redox status in a dimeric inorganic pyrophosphatase
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The X-Files (1993–2018)
TV-14 | 45min | Crime, Drama, Mystery | Episode aired 16 November 1997
In May 1989, the Lone Gunmen meet for the first time when they assist a woman who claims the government plans to use civilians in a secret experiment.
Kim Manners
Chris Carter (created by), Vince Gilligan
David Duchovny, Gillian Anderson, Richard Belzer | See full cast & crew »
X-Files: Personal Favorites
Television Best Of: The X-Files
Impossible to Forget (The X Files)
The Funny X-Files
Rue de Peaña's TV Shows
Search for "Unusual Suspects" on Amazon.com
Title: Unusual Suspects (16 Nov 1997)
Episode complete credited cast:
David Duchovny ... Fox Mulder
Gillian Anderson ... Dana Scully (credit only)
Richard Belzer ... John Munch
Signy Coleman ... Susanne Modeski
Bruce Harwood ... John Fitzgerald Byers
Tom Braidwood ... Melvin Frohike
Dean Haglund ... Richard 'Ringo' Langly
Steven Williams ... Mr. X
Chris Nelson Norris ... Swat Lietenant
Glenn Williams ... Officer
Stuart O'Connell ... 1st Swat Cop
Kenneth H. Hawryliw ... Ken Hawryliw (as Ken Hawryliw)
The origins of the Lone Gunmen and their relationship with Mulder are revealed. All three were at a computer and electronics trade show in Baltimore in May 1989 when they put their antagonism to one another aside to help a woman, Susanne Modeski, who claims her boyfriend kidnapped her daughter. In fact, she's a government scientist on the run from security officers. She tells them about a massive government conspiracy and they inform their new found friend Mulder, who finds it all a bit far-fetched. Written by garykmcd
reference to dungeons and dragons | pulling one's tooth | pay phone ringing | pay phone | trade show | See All (34) »
Crime | Drama | Mystery | Sci-Fi | Thriller
TV-14 | See all certifications »
16 November 1997 (USA) See more »
Stage 2, North Shore Studios, North Vancouver, British Columbia, Canada See more »
Ten Thirteen Productions, 20th Century Fox Television See more »
This is the 100th episode. See more »
Suzanne Modeski asks Byers to help her decode a printout of an encrypted file. However, since almost all file creation and encryption systems make extensive use of non-printing characters (especially for the type of printer used in the episode), it would have been impossible to decipher the information on the paper. See more »
Melvin Frohike: Sure, baby, my kung fu is the best.
References The Geraldo Rivera Show (1987) See more »
Written by Mark Snow
Performed by John Beal
Prequel and the origins to The Lone Gunmen without Scully damn good one
25 June 2019 | by NightmareOnElmStreetFan – See all my reviews
Unusual Suspects is one of my favorite episodes of The X-Files. It is a prequel and an origin story to "The Lone Gunmen" how those three characters Bruce Harwood, Tom Braidwood and Dean Haglund find them selfs. The episode is about The Lone Gunmen they are the stars in this episode, they first appeared in the first season Ep 17 E.B.E. Guest stars: David Duchovny and Steven Williams as X. Gillian Anderson as main character FBI Special Agent Dana Scully is absent from this episode. This is the second time in the last five seasons Scully was absent in this show. The first time Gillian was absent was In Season 2 Episode 7 "3" that was the first episode without Scully this is the second episode without Dana Scully.
This was the first part of two parts episodes. A sequel to the episode was later filmed during the series' sixth season, entitled "Three of a Kind". Unusual Suspects I love to death, it is one of my favorite episodes in the fith Season. I love the gun blazing in which a killers try to gun down Mulder with a machine guns and he ducks. Mulder (David Duchovny) was a bad-ass in this episode. The Lone Gunmen was also a spin off from The X-Files which Byers, Frohike and Langly had their own show but it was canceled after Season 1. During ninth Season Byers, Frohike and Langly were killed off. That is why I hate Season 9! I hate Seasons 7, 8, 9 and 10 I never seen Season 11 and I don't care about these seasons.
Kim Manners directed wonderful this episode and actress Signy Coleman as Susanne Modeski did a good job playing her character.
The origins of the Lone Gunmen are explored. In 1989, two salesmen and a federal employee join forces when they meet Susanne Modeski, a woman who claims that she is being pursued by her violent ex-boyfriend, an FBI agent named Fox Mulder. We learn how agent Mulder came to meet three friendly and familiar faces. Unusual Suspects damn good episode I recommended to The X-Files fans like me.
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PH Equities May Become Uncompetitive Due To Tax Hike
The Tax Reform Acceleration and Inclusion (TRAIN) has imposed a 20% increase in the stock transaction tax. This is forecasted to yield ₱1.7 billion in additional yearly revenue, but the Philippines Stock Exchange (PSE) is worried that it might make local equities less competitive.
According to the PSE president Ramon Monzon, it will lead to a 10-basis point increase in the transaction tax, which translates to a 0.5% to 0.6% increase. It may seem like a small increase, but that increase represents 20% increase from the present one, and thus increasing the friction cost for foreign investors, he said.
Whether losing or gaining in the trade, this will make traders pay an additional 60 basis points, which can be very big for foreign investors who trade in millions of dollars. The existing 0.5% stock transaction tax in the Philippines was already the highest in the region.
“We have to be very conscious of what the other capital markets are doing in the region or even globally. Foreign investors will always go to a place where transaction cost is less. It’s not enough to make money on the trade. If you had the transaction cost, then you become very uncompetitive with other stock exchanges,” he added.
In comparison, the transaction charges for the stocks in our neighboring peers are as follows:
Malaysia (Bursa Malaysia) – 30 basis points of the transaction in the form of stamp duty.
Hong Kong (Hong Kong Exchanges) – 10 basis points of the transaction value in the form of stamp duty.
Vietnam (Ho Chi Minh Exchange) – 10 basis points of gross sale proceeds.
Indonesia – 10 basis points of the transaction amount. Additional 50 basis points charge for founder shares of companies doing Initial Public Offerings (IPO).
Singapore – no stock transaction tax.
Thailand – no stock transaction tax.
The planned increase in the stocks transaction taxes is among the “offsetting” measures included in the TRAIN, as the government sought to lower individual income taxes to boost the net take-home pay of the average Filipino.
TRAIN Revenue Exceeded Government Target
PSEi Jumps Back To 8,000 Mark
Fuel Tax Hike Only Applicable To New Stocks
Philippine Economy Isn’t Vulnerable To China Slowdown…
Get To Know Our CEO Mitul Lakhani
How Do You Design Your Success Story: According to Francis Kong (Part 3)
How To Recognize Your Potential For Success: According to Francis Kong (Part 2)
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JACK OF ALL NERDS SHOW
THE LATEST: 01/20/20
On this week's show, we play our own version of the BBC show "Would I Lie to You?" You can listen to or watch the episode on the Jack Of All Nerds page under the Shows tab.
Benjamin and Kaelan review Star Wars: The Rise of Skywalker on a new episode of Cineblokes. You can listen to or watch the episode on the Cineblokes page under the Shows tab.
Check out our new show: The Midnight Society. You can watch it on the Midnight Society page under the Shows tab.
We discuss the Star Wars sequel trilogy on a new Cinema Saga, under the Shows tab.
Someone tries to stop Phil's plans, in this week's new comic strip. Read it on the Dark Crusader season 4 page.
Check out the history of Witchcraft on our history show: A Brief History of the Past under the Shows tab.
If you love our show and want to lend your monthly support you can pledge as little as $1 or as much as $50 to our Patreon here: Jack Of All Nerds Show Patreon.
The Dark Crusader season 3 book is now available for purchase on the Season 3 page or in our Store!
Welcome!1:13
Don't forget to join us on Facebook, Twitter, and Instagram!
The Jack Of All Nerds show is a Podcast Award Nominated weekly livestream comedy show that discusses all things nerd related and interviews amazing guests. We talk comics, movies, cartoons, gaming, medieval fantasy, sci-fi, comedy, pop culture, cosplay, books, music, and a whole lot more! Some of our notable shows guests have been Jason Narvy (Power Rangers), Thomas Lennon (of Reno 911! and the Odd Couple), Doug Jones (of Batman Returns, Hellboy, Pan's Labyrinth), Anthony DeLongis (whipmaster on Batman Returns and Indiana Jones and the Kingdom of the Crystal Skull), Chris Cassamasa (of Mortal Kombat and Batman & Robin), Larry Wilson (co-creator and producer of Beetlejuice), and many others.
Don't miss our LIVE show on Sunday nights from 7pm-9pm (PST) only on Facebook Live (www.facebook.com/Nerdbotmedia)!
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Jack Of All Nerds
A Brief History of the Past
Cineblokes
Cineblokes Classic
Cinema Saga
How to Survive an Action Movie
The Midnight Society
The Disney Plusketeers
Dark Crusader
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Vana Parva, Mahabharata
(Redirected from Vanaparva)
The following chapters make mention of The Mahabharata Tribes in Vana Parva.
Book III Chapter 11 - Bhima slays Kirmira in Kamyaka Forest in Kurujangala
Book III Chapter 13 -
Book III Chapter 48 - Kings at Rajasuya sacrifice of Yudhisthira attended by the chiefs of many islands and countries: Vangas, Angas, Paundras, Odras, Cholas, Dravidas, Andhakas, Sinhalas, Barbaras, Mlecchas, Pahlavas, Daradas, Kiratas, Yavanas, Sakras, Harahunas, Chhinas, Tukharas, Sindhavas, Jagudas, Ramathas, Mundas, Strirajya, Tanganas, Kekayas, Malavas, Kasmira, Akrura, Gada, Shamva, Pradyumna, Ahuka, Dhrishtadyumna
Book III Chapter 80 - Merit attached to tirthas
Book III Chapter 81 - Mentions names of Pilgrims
Book III Chapter 82 - Tirthas of Dharma
Book III Chapter 85 - tirthas and regions of eastern country
Book III Chapter 86 - Tirthas of South
Book III Chapter 87 - Tirthas of West
Book III Chapter 88 - Tirthas of North
Book III Chapter 114 -
Book III Chapter 154 - Destruction of the Asura Jata by Bhima
Book III Chapter 164 - Matali takes to the celestial regions; Vasus, Varuna,Marutas, Siddhas, Brahma, Gandharva, Uragas, Rakshasas, Vishnu, Nairitas, Amaravati,Vasus, Rudras, Sadhyas, Marutas, Adityas, Aswins, Chitrasena
Book III Chapter 167 - Matali, Asura, Mahendra's weapons, Bana, Tomara, Gandiva
Book III Chapter 170 - Destruction of Hiranyapura, the city inhabited by Pulamas Kalakas and the Kalakeyas, Arjuna's terrible encounter with the Nivatakavachas dwelling in Hiranyaparva. Yaksha, Asura]], Guhyaka, Nairrita
Book III Chapter 174 - Pandvas journey twelfth year of their sojourn in forests having arrived reach Saraswati River:
Lived at Badari for one month, proceeded realm of Suvahu, king of the Kiratas, And crossing Himalayan regions, and the countries of China, Tukharas, Daradas, Darvas and all the climes of Kulindas, rich capital of Suvahu.
Dwaitavana, Dwaitavana lake on Saraswati, See many wild animals and trees like Holy-fig , Rudaraksha, Rohitaka, Cane, Jujube, Catechu, Sirisha, Bel, Inguda, Karira, Pilu and Sami trees grew on the banks of the Saraswati. Inhabited by Yakshas, Gandharvas and Maharshis.
Book III Chapter 267 - Story of from Ramayana crossing the ocean and arrival at Lanka: Vanara Kings Sugriva, Sushena, Gaya, Gavakshya, Gandhamadana, Panasa, Dadhimukha, Nala, Nila, Angada, Kratha, Mainda, Dwivida. Two of Ravana's counsellors and officers, named Suka and Sarana.
Vana Parva Summary
The third parva called Aranyaka (relating to the forest) treats of the wandering of the Pandavas to the forest and the citizens, following the wise Yudhishthira, Yudhishthira's adoration of the god of day; according to the injunctions of Dhaumya, to be gifted with the power of maintaining the dependent Brahmanas with food and drink: the creation of food through the grace of the Sun: the expulsion by Dhritarashtra of Vidura who always spoke for his master's good; Vidura's coming to the Pandavas and his return to Dhritarashtra at the solicitation of the latter; the wicked Duryodhana's plottings to destroy the forest-ranging Pandavas, being incited thereto by Karna; the appearance of Vyasa and his dissuasion of Duryodhana bent on going to the forest; the history of Surabhi; the arrival of Maitreya; his laying down to Dhritarashtra the course of action; and his curse on Duryodhana; Bhima's slaying of Kirmira in battle; the coming of the Panchalas and the princes of the Vrishni race to Yudhishthira on hearing of his defeat at the unfair gambling by Sakuni; Dhananjaya's allaying the wrath of Krishna; Draupadi's lamentations before Madhava; Krishna's cheering her; the fall of Sauva also has been here described by the Rishi; also Krishna's bringing Subhadra with her son to Dwaraka; and Dhrishtadyumna's bringing the son of Draupadi to Panchala; the entrance of the sons of Pandu into the romantic Dwaita wood; conversation of Bhima, Yudhishthira, and Draupadi; the coming of Vyasa to the Pandavas and his endowing Yudhishthira with the power of Pratismriti; then, after the departure of Vyasa, the removal of the Pandavas to the forest of Kamyaka; the wanderings of Arjuna of immeasurable prowess in search of weapons; his battle with Mahadeva in the guise of a hunter; his meeting with the lokapalas and receipt of weapons from them; his journey to the regions of Indra for arms and the consequent anxiety of Dhritarashtra; the wailings and lamentations of Yudhishthira on the occasion of his meeting with the worshipful great sage Brihadaswa. Here occurs the holy and highly pathetic story of Nala illustrating the patience of Damayanti and the character of Nala. Then the acquirement by Yudhishthira of the mysteries of dice from the same great sage; then the arrival of the Rishi Lomasa from the heavens to where the Pandavas were, and the receipt by these high-souled dwellers in the woods of the intelligence brought by the Rishi of their brother Arjuna staving in the heavens; then the pilgrimage of the Pandavas to various sacred spots in accordance with the message of Arjuna, and their attainment of great merit and virtue consequent on such pilgrimage; then the pilgrimage of the great sage Narada to the shrine Putasta; also the pilgrimage of the high-souled Pandavas. Here is the deprivation of Karna of his ear-rings by Indra. Here also is recited the sacrificial magnificence of Gaya; then the story of Agastya in which the Rishi ate up the Asura Vatapi, and his connubial connection with Lopamudra from the desire of offspring. Then the story of Rishyasringa who adopted Brahmacharya mode of life from his very boyhood; then the history of Rama of great prowess, the son of Jamadagni, in which has been narrated the death of Kartavirya and the Haihayas; then the meeting between the Pandavas and the Vrishnis in the sacred spot called Prabhasa; then the story of Su-kanya in which Chyavana, the son of Bhrigu, made the twins, Aswinis, drink, at the sacrifice of king Saryati, the Soma juice (from which they had been excluded by the other gods), and in which besides is shown how Chyavana himself acquired perpetual youth (as a boon from the grateful Aswinis). Then hath been described the history of king Mandhata; then the history of prince Jantu; and how king Somaka by offering up his only son (Jantu) in sacrifice obtained a hundred others; then the excellent history of the hawk and the pigeon; then the examination of king Sivi by Indra, Agni, and Dharma; then the story of Ashtavakra, in which occurs the disputation, at the sacrifice of Janaka, between that Rishi and the first of logicians, Vandi, the son of Varuna; the defeat of Vandi by the great Ashtavakra, and the release by the Rishi of his father from the depths of the ocean. Then the story of Yavakrita, and then that of the great Raivya: then the departure (of the Pandavas) for Gandhamadana and their abode in the asylum called Narayana; then Bhimasena's journey to Gandhamadana at the request of Draupadi (in search of the sweet-scented flower). Bhima's meeting on his way, in a grove of bananas, with Hanuman, the son of Pavana of great prowess; Bhima's bath in the tank and the destruction of the flowers therein for obtaining the sweet-scented flower (he was in search of); his consequent battle with the mighty Rakshasas and the Yakshas of great prowess including Hanuman; the destruction of the Asura Jata by Bhima; the meeting (of the Pandavas) with the royal sage Vrishaparva; their departure for the asylum of Arshtishena and abode therein: the incitement of Bhima (to acts of vengeance) by Draupadi. Then is narrated the ascent on the hills of Kailasa by Bhimasena, his terrific battle with the mighty Yakshas headed by Hanuman; then the meeting of the Pandavas with Vaisravana (Kuvera), and the meeting with Arjuna after he had obtained for the purpose of Yudhishthira many celestial weapons; then Arjuna's terrible encounter with the Nivatakavachas dwelling in Hiranyaparva, and also with the Paulomas, and the Kalakeyas; their destruction at the hands of Arjuna; the commencement of the display of the celestial weapons by Arjuna before Yudhishthira, the prevention of the same by Narada; the descent of the Pandavas from Gandhamadana; the seizure of Bhima in the forest by a mighty serpent huge as the mountain; his release from the coils of the snake, upon Yudhishthira's answering certain questions; the return of the Pandavas to the Kamyaka woods. Here is described the reappearance of Vasudeva to see the mighty sons of Pandu; the arrival of Markandeya, and various recitals, the history of Prithu the son of Vena recited by the great Rishi; the stories of Saraswati and the Rishi Tarkhya. After these, is the story of Matsya; other old stories recited by Markandeya; the stories of Indradyumna and Dhundhumara; then the history of the chaste wife; the history of Angira, the meeting and conversation of Draupadi and Satyabhama; the return of the Pandavas to the forest of Dwaita; then the procession to see the calves and the captivity of Duryodhana; and when the wretch was being carried off, his rescue by Arjuna; here is Yudhishthira's dream of the deer; then the re-entry of the Pandavas into the Kamyaka forest, here also is the long story of Vrihidraunika. Here also is recited the story of Durvasa; then the abduction by Jayadratha of Draupadi from the asylum; the pursuit of the ravisher by Bhima swift as the air and the ill-shaving of Jayadratha's crown at Bhima's hand. Here is the long history of Rama in which is shown how Rama by his prowess slew Ravana in battle. Here also is narrated the story of Savitri; then Karna's deprivation by Indra of his ear-rings; then the presentation to Karna by the gratified Indra of a Sakti (missile weapon) which had the virtue of killing only one person against whom it might be hurled; then the story called Aranya in which Dharma (the god of justice) gave advice to his son (Yudhishthira); in which, besides is recited how the Pandavas after having obtained a boon went towards the west. These are all included in the third Parva called Aranyaka, consisting of two hundred and sixty-nine sections. The number of slokas is eleven thousand, six hundred and sixty-four.
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Your Store / Industry / Retail
Movin’ On Up: 5 Jewelry Retailers’ Best Tips for Changing Locations
June 15, 2019 by Daniel P. Smith
Long Sabre with blue sapphire baguettes and diamonds in 18k yellow gold; $5,447; Robinson Pelham; gatehouse. emily@robinson pelham.com; robinson pelham.com
Every year, owners of jewelry stores around the country endure a daunting task when they pack up and move their wares into a new location. As landlords change, demographics shift, or business priorities evolve, retailers relocate their stores to better position their operations for future success.
JCK spoke to five retailers who have recently moved their businesses, exploring the factors that prompted their change of address and soliciting suggestions for how other store owners can put together a successful relocation plan.
Designer’s Touch Jewelry
Wellington, Fla.
In March, this third-generation jewelry retailer ditched its longtime Wellington home, where neighbors had transitioned over the years from vibrant restaurants and salons to utilitarian medical offices. Relocating a few miles down the road, Designer’s Touch took up residence in a newly constructed shopping plaza anchored by a Trader Joe’s and drive-thru Starbucks. The move also allowed Designer’s Touch to create a more contemporary interior, including a cozy customer lounge area.
The motivating factor: location, location, location, according to co-owner Adam Yorke. “One of the big things in my mind was making sure the location was an active one with shops that related to the quality of our shop. We weren’t interested in running to just any new place because it might have been larger or offered a better rent.”
A moving tip: Plan ahead. From interior paint colors and setting up utilities to installing security and communicating the move to customers, Yorke says an assortment of easy-to-overlook details must be addressed and organized before a move. “The more you figure out early, the easier your life will be as the move date comes closer.”
Gem Jewelry Boutique
Oak Park, Ill.
In 2015, Gem owner Laura Kitsos moved for a second time in five years, settling into a historic storefront in Oak Park, an artsy suburb on Chicago’s western edge. Kitsos calls her current home—which features custom cases, illumination by a professional lighting designer, and windows featuring the Gem name in 24k gold gilt—a more intimate environment that jibes well with the indie boutiques lining local streets.
The motivating factor: “The prior space was beautiful, but way too large for us,” Kitsos says, admitting that she hurried into her first Oak Park space after getting pushed out of Gem’s former location in Chicago’s Bucktown neighborhood.
A moving tip: Don’t fear the unknown. “[Moving] shakes things up and gives you the chance to do something new and different than before,” Kitsos says. “You create excitement and will always find new customers when you move a shop or change the dynamics of your current shop.”
Ephraim Doumato Jewelers
Greenville, R.I.
Last November, Ephraim Doumato Jewelers traded its 1,500-square-foot home of nearly 40 years for a 4,000-square-foot space located a half-mile away. Once a popular Chinese restaurant, the retailer’s new store features added parking, a wider selection of inventory, a customer lounge with televisions, a “diamond bar” where clients can shop for engagement rings or remounts while enjoying a complimentary drink from the full-service bar, and a diamond-viewing room for buyers seeking privacy.
The motivating factor: “The opportunity to grow our business in a larger, more visible location that we owned was our goal for a long time,” says Matt Doumato, whose father, Ephraim, founded the business in 1980.
A moving tip: Don’t settle. “Because this is a huge undertaking, make sure there are significant benefits to the new location over the old, such as space potential, greater visibility, or filling a void in the market,” Doumato says. He also urges retailers to hold a moving sale, which can inject capital into the business and create awareness for its move, something Doumato Jewelers cleverly did by distributing fortune cookies noting the retail store’s new address.
Lawrence Jewelers
Fort Gratiot Township, Mich.
After inhabiting a 1,500-square-foot space in Fort Gratiot’s Birchwood Mall for the last 22 years, Lawrence Jewelers settled into its new freestanding building in March. Located about a quarter-mile away from its mall location, one that had seen key anchor tenants vanish in recent years, the 44-year-old retailer’s new 6,000-square-foot home includes new brands and more contemporary inventory, two waterfall features, a luxurious customer lounge, a full refreshment bar, a private diamond-viewing area, and a custom CAD area.
The motivating factor: Declining mall traffic, hefty real estate costs, and the opportunity to be in a high-traffic area were all considerations. “We did it for the convenience of our guests and to be constantly visible to passersby,” co-owner Jon Askew says.
A moving tip: Leverage credible help. “We did a retirement sale during the relocation and hired an outside company to help bring in additional merchandise and take care of the marketing focus,” Askew says. Assigning one staff member to oversee the move, including planning for delays and creating contingency plans, also helped ease the store’s relocation effort.
Lori McLean Fine Jewelry
Designer Lori McLean moved her namesake jewelry store from Manhattan’s West Village to the adjacent East Village neighborhood in 2014, settling into a cozy, more cost-effective space rich in natural light, storage space, and elbow room that has allowed McLean to better craft and showcase her own jewelry line and custom work.
The motivating factor: Simply put, McLean’s 10-year lease ended, and the West Village’s soaring rents rose far beyond her comfort level. Though initially bummed to leave her home of a decade, a classic New York building with tall, tin ceilings and a stately wooden door, McLean now considers her shift 1 mile to the east “a great change” for her now–15-year-old retail business.
A moving tip: Maintain perspective and control what you can. “I used to really worry about what would happen when my lease ended, and then it did and almost everything improved. Now I try not to worry about how little control I have over the big sweeping changes,” says McLean, acknowledging that she may be on the move again next year when her current lease expires. “Who knows?”
Long Sabre with blue sapphire baguettes and diamonds in 18k yellow gold; $5,447; Robinson Pelham; gatehouse.emily@robinsonpelham.com; robinsonpelham.com
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Contemporary Visual Culture in
North Africa and the Middle East
Quick search Go
Platform 010: Where to Now? Shifting Regional Dynamics and Cultural Production in North Africa and the Middle East 009: What are the genealogies of performance art in North Africa and the Middle East? 008: How do we productively map the historical and contemporary relationships that exist between North Africa, the Middle East and the Global South? 007: What is the future of arts infrastructures and audiences across North Africa and the Middle East? 006: What role can the archive play in developing and sustaining a critical and culturally located art history? 005: How has a globalised cultural economy affected the production of contemporary visual culture in North Africa and the Middle East? 004: With the benefit of hindsight, what role does new media play in artistic practices, activism, and as an agent for social change in the Middle East and North Africa today? 003: Can Artistic Practices Negotiate the Demands of Cultural Institutions, Public Space, and Civil Society? 002: What relationship does visual culture have to the world we live in? 001: What do we need to know about the MENA region today?
With the benefit of hindsight, what role does new media play in artistic practices, activism, and as an agent for social change in the Middle East and North Africa today?
'Networks have no inside, only radiating connectors. They are all edges. They provide connections but no structure. One does not reside in a network, but rather moves to other points through the edges'. Bruno Latour, 'Some Experiments in Art and Politics', e-flux journal, 03/2011. With the benefit of hindsight, one...
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Banner image: Hassan Khan, The Knot, 2012, commissioned by dOCUMENTA (13), produced by Galerie Chantal Crousel, Paris, co-produced by the Young Arab Theater Fund (YATF), glass Sculpture 70 cm long x 3 cm thickness x 6.5 cm width in the middle of the knot. Courtesy of the artist and Galerie Chantal Crousel. Photograph by Anders Sune Berg.
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Central African Republic: Anti-Balaka militias kidnap vice president amid new surge of violence
By Elsa Buchanan
October 19, 2015 11:46 BST
Anti-Balaka Christian fighters have kidnapped the vice president in Central African Republic (CAR) in the wake of a new surge in violence between Muslim and Christian militias.
The CAR conflict erupted when by Michel Djotodia, a Muslim, overtook Christian former president Francois Bozize in 2013. As a result of the political unrest, Muslim Seleka and Christian anti-Balaka militias have engaged in tit-for-tat violence that killed thousands of people and prompted hundreds of thousands to flee their homes.
President Michel Djotodia – who replaced Bozize following the coup – was forced to resign in January 2014, as he was accused of being unable to halt the unrest. He was replaced by Catherine Samba Panza, deemed as politically neutral.
Anti-Balaka demands to government
Around 50 armed anti-Balaka forces stopped the car transporting the vice president of CAR's National Transitional Council, Léa Koyassoum Doumta, as she was returning from a funeral around 90 kilometres from Bangui at 4pm on Sunday (18 October).
The militias disarmed the two security guards travelling with her before taking them to a location out of sight.
Anti-balaka fighters from the town of Bossembele rest while on patrol in the Boeing district of Bangui, Central African Republic Camille Lepage/Reuters
Doumta explained how she negotiated for more than two hours with her abductors before they released her with a list of demands for her government.
Later on Sunday, the militias then kidnapped six CAR gendarmes, who they only released after the government intervened.
The anti-Balakas demanded, among other things, the release of several people arrested earlier in the week.
At the time of publishing it was still unclear whether the government had responded to any demands.
New surge of violence
This month, CAR's interim president Catherine Samba Panza announced the postponement of a presidential election following renewed violence that left dozens of people dead in the capital Bangui.
The capital Bangui was under lockdown at the end of September after 42 people were murdered in retaliation following the decapitation of a Muslim motorcycle taxi driver.
Members of the Christian militia attacked the Ngaragba prison in Bangui, freeing more than 500 prisoners – most of them so-called "anti-Balaka" Christian fighters.
An investigation on war crimes by the International Criminal Court is ongoing.
More about Central African Republic conflict
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UN \'covered up\' rape of African boys by French peacekeepers, alleges aid worker
France: François Hollande vows punishment for any child rapes in Central African Republic
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T-Systems SA relocates head office, aligns workspace with new transformation strategy
Issued by Evolution PR for T-Systems
Dineo Molefe, MD at T-Systems
Driving higher performance
As the company moves towards a ‘leaner’ model that focuses on customer centricity and partnerships, it requires a new open, flexible workspace that fosters transparency, agility, collaboration and accountability to drive higher performance. The office space is also geared towards comfort, wellness and convenience with an open plan design that enhances communication.
Supporting the strategy
Says Dineo Molefe, MD at T-Systems South Africa: “As we move forward, embracing a new way of doing business, this requires a new working environment that supports our goals. Our people are central to achieving our Business 2020 Transformation Strategy and play a pivotal role in creating an innovative, dynamic and agile environment for the growth of the business, not just in a profitable way but also in a meaningful manner too.”
Molefe is transforming the business to drive growth and stability for the business amid a challenging marketplace and a changing client base. She explains: “This has driven us to create a strong focus on our core competencies and identify new opportunities where we can leverage our strengths, expertise and international muscle. We are continuing to drive business in our areas of excellence, identifying what no longer serves our customers and our business, pursuing opportunities for us to jointly succeed with our partners and customers and ensuring we conduct business with integrity.”
Transforming for success
T-Systems has transformed its business in order to assist its customers to streamline and improve performance across the enterprise, strengthening agility and security while simplifying the integration of new technology with existing infrastructure. To achieve this transformation, T-Systems South Africa has streamlined the organisation to focus on the following four enablement areas for its customers.
Connectivity – the basis for successful digitisation, we apply highest quality standards and operational excellence, offering fast, agile and secure access to data and applications worldwide.
Digital – building tomorrow needs a trusted and skilled digital services provider that can integrate cloud, IOT, security and networks with an agile end-to-end approach.
Cloud and infrastructure –harnessing the potential of cloud for a business: use the experience of a multi-cloud orchestration provider and a cloud pioneer with more than 10 years of experience.
Security –with Europe’s largest integrated Cyber Defense and Security Operation Centre, we create the Cyber Security Protection Shield for our customers. We offer the same high, professional standard “Made in Germany” with which we protect ourselves.
Molefe explains further: “These are the foundations that deliver value in our customers’ business, creating the underlying framework to thrive in a digital economy where innovation and disruption is fundamental to success and sustainability. Our goal is to evolve our customers’ business and resolve their greatest challenges, enabling them to better manage complexity and focus on opportunities to accelerate their success.
“We are also tightening our strategic vendor partnerships and integrating our sales and delivery areas to create more value and deliver seamless services.”
The company’s Business 2020 Transformation Strategy will continue to support its Nation Building Initiative that is aligned with the National Development Plan 2030, boosting education, skills transfer and employment opportunities for South Africa’s youth.
Molefe concludes: “I am excited about the strategy, transformation and relocation to new premises and the possibilities it creates for a more focused organisation. This strengthens our ability to resolve critical business issues for our customers in a competitive environment and enabling them to thrive.”
About Deutsche Telekom: https://www.telekom.com/en/company/at-a-glance
About T-Systems: T-Systems company profile
About T-Systems South Africa: TSSA Company Profile
Reabetswe Madumo (+27) 011 462 0628 reabetswe@evolutionpr.co.za
Marketing Specialist Elize van Rooyen (+27) 21 974 3185 Elize.vanRooyen@t-systems.co.za
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2 brothers accused of having shotgun on campus
Updated: 9:01 AM CST Mar 11, 2016
Authorities say two brothers were taken into custody after a shotgun was found in their car on the Iowa Western Community College campus in Council Bluffs.They were identified as 19-year-old Eric and 18-year-old Edrick Maymon, of Markham, Illinois. The two were arrested on charges of harassment, trespassing and carrying a weapon on school grounds.Online court records don't list the names of attorneys who could comment for the Maymons. Jail records say the brothers remained in custody Friday. They both attend the school.Some students had reported Thursday that the two made threatening comments and gestures as they drove by. Police say officers found the brothers in a student's room later and then found the shotgun in the car.
COUNCIL BLUFFS, Iowa —
Authorities say two brothers were taken into custody after a shotgun was found in their car on the Iowa Western Community College campus in Council Bluffs.
They were identified as 19-year-old Eric and 18-year-old Edrick Maymon, of Markham, Illinois. The two were arrested on charges of harassment, trespassing and carrying a weapon on school grounds.
Online court records don't list the names of attorneys who could comment for the Maymons. Jail records say the brothers remained in custody Friday. They both attend the school.
Some students had reported Thursday that the two made threatening comments and gestures as they drove by. Police say officers found the brothers in a student's room later and then found the shotgun in the car.
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Grover Wray
The Trust Project at Northwestern University
Senior Vice President and Chief Human Resources Officer
DigitalGlobe / Human Resources
Grover Wray is senior vice president and the chief human resource officer at DigitalGlobe, a vendor of high-resolution earth imagery. Its clients include a wide range of government, nonprofit, and private-sector organizations, and he is responsible for all HR activities, including talent acquisition and management. Before moving to DigitalGlobe, he was executive vice president of human resources at Western Union, a Fortune 500 company, and led the HR activities associated with its spin-off from First Data Corporation in 2006. In that role, he created an initiative to identify core values for the new Western Union Company.
Email the Trust Project Email The Trust Project
Videos by Grover Wray
Building Team Trust to Manage Change at Work
Contributor / Grover Wray
Grover Wray Human Resources Human Resources,Mergers and Acquisitions,Reputation Management,Social Psychology As a Chief Human Resource Officer, trust is fundamental to being able to ensure that employees are engaged, they are motivated by what they do and they can contribute a degree of value back to the organization, and in return the organization gives them a degree of value. And when that equation of value that the person gives to the organization is equal to the value that the organization is giving to them, then you have trust. That’s what trust is built on. And so as a Chief Human Resource Officer it’s absolutely critical to ensure that you are effectively building mental maps for all of your team members starting with those who come into the organization on day one.
Essentially a mental map is an ability for somebody to be able to anticipate and to expect what might happen. An example, a simple example would be driving to and from work. If we drive to and from work every day the same way, very soon we have a route. We don’t think about what we’re doing; we just start to drive and the next thing you know you’ve arrived at your destination and you find that you arrived without even giving a thought to how you got there.
BUMPER: Understanding Trust through Mental Maps
When I was first introduced to this idea of mental maps it was through the work that I was doing with Arthur Anderson. I got a phone call one day from a partner who said, “We are thinking about outsourcing this accounting function and I was visiting with the CEO of this company and he said you’ve put a lot of effort and time into making sure that the technical transition of this work goes smoothly. But if you’re going to be in this business full-time you better put as much attention to how you manage the people as you do the technical transition.”
I ended up visiting with the CEO and ended up visiting with all of the team members and that’s when the light bulb went on for me. It was the CEO who understood the dynamic of what was happening to his team members who had an expectation, a trust, and this trust was a very significant trust because it was in a small town. It was a few team members.
And it was at that moment that I realized that these employees could not go through a transition like this without understanding the expectations of what a new company was going to provide to them. And it was then that I realized the power of that mental map and applied that in every situation that we encountered after that, and in every situation almost to a T that process or principle worked very well, because you were addressing exactly what the issues were and the uncertainty that gets created when a mental map gets destroyed.
BUMPER: 5 Steps to Building Trust During Mergers
I realized that principle of a mental map was exactly what was needed inside a merger and acquisition or significant change situation. An employee was in an uncertain moment when all of a sudden the mental map that they had built about themselves and from the company was now gone. The trust that the organization had placed in them and they had placed in the organization was now gone. And without replacing that trust with a new map that would build new trust you would never gain the emotional commitment of the team members.
As a leader, the first thing you have to understand is the very first question that somebody has to have answered for them before you can provide any more information to them is: Do I have a job?
The next layer of that foundation is: What are my salary and benefits?
If that question is answered then the third question in that layer of questions becomes: Who is my manager?
And then the fourth question in that layer is: What is my team or who is my team? Who will I be interacting with?
And then the fifth layer, which is the most important layer, but it’s the last layer – (which is somewhat counterintuitive) is the culture. What is the culture of the organization like? What are the values of the organization? If you start with culture, which sometimes we might tend to do because we want that to be seen as a very positive thing, that’s good but I still don’t know whether I have a job. And so it’s not going to resonate with me until you answer those other foundational questions.
Follow that pattern through, and each of those pieces of the pattern put another piece into the mental map until you have sufficiently formed a mental map for that individual as they move into a new environment.
Share Trust
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Brenna Argall
Vahe Ayvazian
Jeanne Brett
Bruce Carruthers
Lynda Chin
Douglas Conant
Cecily Cooper
Raymond De Vries
Eli Finkel
Sanford Goldberg
Kent Grayson
Brayden King
Sanjay Khosla
Melissa Koenig
Harry Kraemer
Niko Matouschek
Kelly Michelson
J. Keith Murnighan
Todd Murphey
Col. John A. O’Grady
Larry Rosen
Paola Sapienza
Praveen Sharma
Andrew Swinand
Rima Toure-Tillery
Adam Waytz
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Shops are secure @ DFO with KRGS Doors
Location: Homebush NSW
Sydney’s leading retail factory outlet, DFO Homebush, redevelopment to accommodate an expansion of its Australian, international and luxury retail offering. The western suburbs shopping destination will expand from 86 stores on a single level to feature 126 stores across two levels. The city’s first combined factory outlet and homemaker centre will include 90 fashion retailers plus 18 bulky goods and homewares stores. The new-look centre will feature a mix of leading luxury retailers as well as popular mainstream brands, and a new 475-seat food court dining precinct. The redevelopment will also include a significant upgrade to the existing DFO complex and improved car parking services to support the additional retail space. Head of Development for CFSGAM Property, Mr Tony Gilchrist said “The redevelopment of DFO Homebush will also include improved car parking facilities, a sleek and clean interior design, and new family amenities which will couple the new retail space, ensuring the customer experience is enhanced across the board,” KRGS used different styles of commercial shop doors to meet the requirements of the car parking facilities and also to complement the requirements of the new sleek and clean interior design. Read more on our products here. For more information on DFO visit the website.
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RSV infecting hundreds of local babies
There have been 51 confirmed cases at Cardinal Glennon Hospital this month and 118 cases at Children’s Hospital this week.
Author: Rhyan Henson
Published: 5:28 PM CST December 27, 2018
Updated: 1:06 PM CST December 31, 2018
ST. LOUIS - Local doctors are warning parents of young children to be on the lookout for Respiratory Syncytial Virus or RSV.
There have been 51 confirmed cases at Cardinal Glennon Hospital this month and 118 cases at St. Louis Children’s Hospital this week. That number can be even higher because a lot of times doctors treat the symptoms without even testing. Doctors expect the numbers to climb as we get deeper into winter.
One of the babies on the mend at Cardinal Glennon is Seamus Grinnan. He spent his first Christmas in the hospital recovering from the respiratory virus.
"We were steaming him in the bathroom and starting to break up some mucus with the hot shower steam," his mother Jessica Grinnan said.
Nothing worked, so she brought him in to Cardinal Glennon thinking he was suffering from a really bad cold only to find out Seamus was battling RSV.
Dr. David Wathen at Cardinal Glennon said RSV inflames children’s airways.
"They start to look like they are working really hard to breathe,” Dr. Wathen said. “Their oxygen saturations start dropping. You see the stomach sucking in. In between the ribs, the ribs become defined when they breathe."
RELATED: Doctors warn of respiratory virus affecting kids and adults
The symptoms are similar to a common cold: runny nose, chest congestion and coughing.
The best way to prevent it is to wash your hands often and keep babies away from second-hand smoke. Dr. Wathen said the virus makes babies want to feed less.
“If they have less than one diaper every eight hours, that's a sign they are becoming dehydrated," he said.
Because of his treatments, Seamus can’t feed normally.
"He thinks he's hungry this whole time, he does his little hungry cries,” his mother said. “All you can is give him his sweeties to calm him down so he goes back to sleep."
RSV typically lasts two weeks and primarily affects babies under the age of 2.
If you think something’s wrong, get your child checked out, especially this time of year, Grinnan said.
There is a vaccine available, but it's reserved for the most vulnerable babies. The vaccine is called Synagis. According to the vaccine's website, "SYNAGIS gives babies who are born prematurely (at or before 35 weeks, and who are 6 months of age or less at the beginning of RSV season) the infection-fighting antibodies they lack, helping protect their vulnerable lungs from RSV."
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06/10/15 Eric Steven Miller, of Vermont, to be United States Attorney for the District of Vermont for the term of four years, vice Tristram J. Coffin, resigned.
05/13/15 Sally Quillian Yates, of Georgia, to be Deputy Attorney General, vice James Michael Cole, resigning.
03/12/15 Yates Letter - GA AG Olens 3-11-2015
03/20/15 Yates King & Spalding Letter 31915
03/20/15 Yates Letter Atlanta Bar fmr. Presidents 31915
03/20/15 Yates Letter Grindler 31915
03/20/15 Yates Letter NOBLE 31915
03/20/15 Yates Letter - Former USAs 3-20-2015
03/20/15 Yates Letter Former Senior DOJ Officials 32015
03/20/15 Yates Letter Rev. Warnock 32015
03/23/15 Yates Letter - Louis Freeh 3-16-2015
03/26/15 Yates Letter CT Vivian 32615
03/26/15 Yates Letter - Urban League of Atlanta
03/26/15 Yates Letter - APA
03/26/15 Yates Letter - Chief Turner
04/08/15 Yates Letter - Gov Deal 3-26-15
04/10/15 Yates Letter - Major Cities Chiefs 4-10-2015
04/23/15 Loretta E. Lynch, of New York, to be Attorney General, vice Eric H. Holder, Jr.
Nomination Number: PN4-114
01/30/15 Lynch Letter PFAW 12615
01/29/15 Lynch Letter Martin County Resolution 10715
01/29/15 Lynch Letter Joseph Guccione 12315
01/29/15 Lynch Letter NYCLA 12315
01/29/15 Lynch Letter County of Durham 121514
01/29/15 Lynch Letter John Gilbride 12615
01/29/15 Lynch Letter NAACP LDF 12715
01/29/15 Lynch Letter NCWBA 12815
01/29/15 Lynch Letter Kevin OConnor 12215
01/29/15 Lynch Letter Tursi 12215
01/29/15 Lynch Letter Former NYC Bar Presidents 12215
01/29/15 Lynch Letter Jamie Gorelick 12615
01/29/15 Lynch Letter APA 12715
01/29/15 Lynch Letter Larry Thompson Former Pepsico EVP 12715
01/29/15 Lynch Letter UnitedHealth Group 12315
01/29/15 Lynch Letter NBA 12915
01/29/15 Lynch Letter FBIAA 12715
01/29/15 Lynch Letter AFJ 12715
01/29/15 Lynch Letter AA MP GC 12815
01/28/15 Lynch Letter - NYPC 1-26-15
01/27/15 Lynch Letter -The Honorable John Lewis 12715
01/27/15 Honorable Michael Honda re Lee 12615
01/27/15 Lynch Letter Leadership Conference 12615
01/27/15 Lynch Letter NBPA 12215
01/27/15 Lynch Letter YWCA 12715
01/26/15 Lynch Letter Coalition 12115
01/26/15 Lynch Letter National Urban League 12615
01/26/15 Lynch Letter NWLC 12615
01/26/15 Lynch Letter - EDNY 12-9-14
01/23/15 2014-12-17 CJA Sassower in opposition to Lynch
01/20/15 Freeh re Lynch
01/22/15 FLEOA re Lynch
01/22/15 Former USAs re Lynch
01/08/15 MCCA re Lynch
01/22/15 Hogan Lovells Partners re Lynch
01/23/15 AGAC (12192014)Part5
01/23/15 EARS_Redacted FINAL
01/20/15 NDAA re Lynch
01/20/15 Kathleen Rice re Lynch
01/20/15 National Organization of Black Law Enforcement re Lynch
01/20/15 Federal Bar Council Presidents re Lynch
01/20/15 Estee Lauder re Lynch
01/20/15 ALCOA re Lynch
01/20/15 Congressional Black Caucus re Lynch
12/03/14 Former USAs-EDNY re Lynch 12-3-14
02/12/15 Lynch - Letter HRC 2-11-15
02/12/15 Lynch - Letter NASW 1-27-15
02/27/15 Lynch Letter Legal Momentum TWLDEF 2-25-15
02/27/15 Lynch Letter ANCBEO 2-23-15
02/27/15 Lynch Letter IACP 2-25-15
03/10/15 Lynch Letter Women's Legal Defense & Education Fund 2252015
03/10/15 Lynch Letter NDRN 332015
03/16/15 Lynch Letter - Eric Schneiderman NY AG 3-13-2015
03/12/15 Michael Greco, of New York, to be United States Marshal for the Southern District of New York for the term of four years, vice Joseph R. Guccione, term expired.
03/12/15 Ronald Lee Miller, of Kansas, to be United States Marshal for the District of Kansas for the term of four years, vice Walter Robert Bradley, retired.
03/09/15 Michelle K. Lee, of California, to be Under Secretary of Commerce for Intellectual Property and Director of the United States Patent and Trademark Office, vice David J. Kappos, resigned.
03/09/15 Daniel Henry Marti, of Virginia, to be Intellectual Property Enforcement Coordinator, Executive Office of the President, vice Victoria Angelica Espinel, resigned.
12/09/14 US Chamber of Commerce re Marti 12-09-2014
12/09/14 ESA re Marti 12914
11/10/14 HBADC re Marti 1110 14
11/07/14 MPAA re Marti 110714
11/05/14 INTA re Marti 11514
11/14/14 Copyright Alliance re Marti 111414
11/20/14 CreativeFuture re Marti 112014
10/31/14 NMPA re Marti 103114
11/10/14 AIPLA re Marti 111014
02/09/15 Michael P. Botticelli, of the District of Columbia, to be Director of National Drug Control Policy, vice R. Gil Kerlikowske, resigned.
01/12/15 Sarah R. Saldana, of Texas, to be an Assistant Secretary of Homeland Security (Confirmed)
Last Action: By unanimous consent agreement, debate and vote 12/16/2014.
10/28/14 Engine Advocacy re Lee 102814
11/14/14 IP Attorneys re Lee 111414
11/05/14 INTA re Lee 11514
12/01/14 ACE re Lee 12-1-14
12/05/14 ADA re Lee 12-5-14
12/08/14 NAPABA re Lee 12814
12/09/14 AIPLA re Lee 12-9-14
09/04/14 ASAM re Botticelli ONDCP 9414
09/09/14 NASADAD re Botticelli 9-9-14
09/10/14 Pheonix Multisport re Botticelli 91014
09/11/14 National Council for Behavioral Health re Botticelli ONDCP 9-11-14
09/16/14 NACCHO re Botticelli 9-16-10
09/19/14 CADCA re Botticelli ONDCP 91914
09/24/14 NADCP re Botticelli 9-24-14
09/26/14 Partnership for DrugFree Kids re Botticelli 92614
09/29/14 NCADD re Botticelli 92914
10/08/14 APA re Botticelli 100814
10/08/14 CRC re Botticelli 10814
10/13/14 SLC re Botticelli 101314
10/15/14 CCFF re Botticelli 101514
10/16/14 NAPHS re Botticelli 101614
10/17/14 VRN re Botticelli 10-17-14
10/23/14 Health & Social Services re Botticelli 102314
10/30/14 NDAA re Botticelli 103014
10/31/14 NAADACre Botticelli 103114
11/02/14 Zwick re Botticelli 11-2-14
11/03/14 ADDSIA re Botticelli 11314
11/04/14 Criminal Justice Stakeholders re Botticelli 11414
11/05/14 FAVOR re Botticelli 11514
11/07/14 NACA re Botticelli 11714
11/09/14 Northeastern University re Botticelli 11914
11/10/14 LAC re Botticelli 11-10-14
11/10/14 NFP re Botticelli 111014
11/10/14 Partnership Groups re Botticelli 111014
11/10/14 HBADC re Botticelli 111014
11/10/14 NAADPC re Botticelli 111014
11/10/14 Lines for Life re Botticelli 111014
11/10/14 Kay Sanford, Injury Consultant re Botticelli 111014
11/11/14 AMERSA re Botticelli 111114
11/12/14 MCSA re Botticelli 111214
11/12/14 AMA re Botticelli 111214
11/12/14 Opioid Safety and Naloxone Orgs. re Botticelli 111214
12/16/14 John Charles Cruden, of Virginia, to be an Assistant Attorney General (confirmed)
William K. Suter, Clerk of the U.S. Supreme Court (Ret.), Major General, Judge Advocate General's Corps, U.S. Army (Ret.) re Cruden
Former Employees of the Environment and Natural Resources Division (ENRD) of the Department of Justice re Cruden
Former Presidents of the District of Columbia Bar
John D. Altenburg, Jr., Major General, U.S. Army, Retired
United States Military Academy Classmates re Cruden
Wayne S. Balta, Vice President, Corporate Environmental Affairs and Product Safety, IBM
Current and past Chairs of the American Bar Association Section on Environment, Energy, and Resources
Professors of Environmental Law
Carol E. Dinkins, Former Deputy Attorney General
03/05/14 Carl Smallwood, President, National Conference of Bar Presidents re Cruden
03/06/14 EPA Officials re Cruden
12/16/14 David Rivera, of Tennessee, to be United States Attorney for the Middle District of Tennessee for the term of four years (confirmed)
12/16/14 Arthur Lee Bentley III, of Florida, to be United States Attorney for the Middle District of Florida for the term of four years, vice Robert E. O'Neill, resigned.
09/15/14 Debo P. Adegbile, of New York, to be an Assistant Attorney General, vice Thomas E. Perez, resigned.
The Lawyers' Committee for Civil Rights Under Law
Marcia L. Fudge, Chair, Congressional Black Caucus
Siobhan Esposito
Consortium for Citizens with Disabilities
R. Seth Williams, District Attorney, Philadelphia, Pennsylvania
Detective Terrance Daniels, Retired, New York City Police Department
Congressman John Lewis, 5th District, Georgia
Governor Deval L. Patrick, Commonwealth of Massachusetts
John I. Dixon, National President, National Organization of Black Law Enforcement Executives
Members of the United States Supreme Court bar
Richard Wells, President, The Police Conference of New York, Inc.
Maureen Faulkner, Justice for Police Officer Daniel Faulkner
James R. Silkenat, President, American Bar Association
Kenneth P. Thompson, District Attorney, Kings County, Brooklyn, New York
Sam A. Cabral, International President, International Union of Police Officers Associations AFL-CIO
Nicholas Turner, President and Director, Vera Institute of Justice
Boyd M. Johnson, III., former Deputy United States Attorney, Southern District of New York
Rea Carey, National Gay and Lesbian Task Force Action Fund
David Raskin, former Assistant U.S. Attorney, Southern District of New York
Nicholas J. Panarella; Christopher C. Panarella; Former NYU Classmates
Hilary O. Shelton, Director, NAACP Washington Bureau & Senior Vice President for Advocacy and Policy
David Godosky, former Assistant District Attorney, Bronx County; former Criminal Court Judge, City of New York
Congressman Hakeem S. Jeffries
Ken Chenault, Chairman and CEO of American Express
Marge Baker, Executive Vice President for Policy and Program, People for the American Way; Paul Gordon Senior Legislative Counsel, People for the American Way
Theodore V. Wells, Jr., Co-Chair of the Litigation Department at Paul, Weiss, Rifkind, Wharton & Garrison LLP
Shanna L. Smith, President and CEO, National Fair Housing Alliance
Eric T. Schneiderman, New York State Attorney General
Nancy Duff Campbell and Marcia D. Greenberger, Co-Presidents, National Women's Law Center
Curt Decker, Executive Director, National Disability Rights Network
Current and Former Presidents of Connecticut College
Abed A. Ayoub, Director of Policy & Legal Affairs, American-Arab Anti-Discrimination Committee
Pamela D. Zilly, Former President of the Connecticut College Board of Trustees
Seth P. Waxman, Wilmer Hale
Randy Hertz, Professor of Clinical Law, New York University School of Law
Drew S. Days, III, Former Assistant Attorney General for the Civil Rights Division, Department of Justice
06/24/14 Leon Rodriguez, of Maryland, to be Director of the United States Citizenship and Immigration Services, Department of Homeland Security, (Confirmed)
01/09/14 J. Alan Johnson, Former U.S. Attorney, Western District of Pennsylvania
01/14/14 Major Cities Chiefs Association
01/14/14 Arthur Wallenstein, Director, Department of Correction and Rehabilitation, Montgomery County, Maryland
01/14/14 J. Thomas Manger, Chief of Police, Montgomery County, Maryland
01/15/14 Lori Grifa, Wolff & Samson PC
01/27/14 Dennis R. Hawkins
02/14/14 Congressman Michael M. Honda, 17th District, California
03/24/14 National Council of La Raza
03/26/14 National Hispanic Leadership Agenda
04/02/14 Sanford Teplitzsky, Chair, Ober Kaler Health Law Practice Group
04/02/14 Howard L. Sollins, Ober, Kaler, Grimes & Shriver
04/02/14 Lawrence A. Shulman, Attorney at Law
04/02/14 Police Executive Research Forum
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A|A Press room Career Tenders Contact PL / EN
New-generation network heat
Shares and shareholders structure
Downoload
The Company’s History
Care for the Environment
Stock market information
Shareholders stucture
Public offering
Quotation of KOGENERACJA shares:
The historical quotations of the Company’s shares are available on the website of the Warsaw Stock Exchange: https://www.gpw.pl/spolka?isin=PLKGNRC00015
Full name Zespół Elektrociepłowni Wrocławskich
KOGENERACJA S.A.
Short name KOGENERACJA S.A.
Name on WSE/ ticker KOGENERA / KGN
ISIN code PLKGNRC00015
Share capital 74 500 000 PLN
Number of shares 14 900 000
Nominal value of shares 5 PLN
IPO 26th May 2000
Market / Segment Primary / 250 plus
Sector Energy
Component of indexes WIG, sWIG80, WIG-ENERG, RESPECT, WIG-Poland, InvestorMS
Shareholder Number of shares
% of shares Number of votes % of votes
PGE Energia Ciepła S.A. 8 652 173 58.07 8 652 173 58.07
Aviva OFE Aviva Santander 1 489 000 9.99 1 489 000 9.99
OFE PZU Złota Jesień 1 160 000 7.79 1 160 000 7.79
Aegon OFE 960 690 6.45 960 690 6.45
Nationale-Nederlanden OFE 746 117
5.01 746 117 5.01
Others 1 892 020 12.70 1 892 020 12.70
Total 14 900 000 100.00 14 900 000 100.00
On November 13, 2017, the PGE Group acquired EDF assets in Poland (Current Report 26/2017) and in connection with an indirect acquisition of shares of KOGENERACJA S.A. owns 50% plus 1 share and holds 50% plus 1 vote at the General Meeting.
On March 14, 2018, as a result of the announced tender offer for subscription for the sale of shares of KOGENERACJA S.A., PGE Group has achieved 58.07% of the total number of votes at the General Meeting of the Company.
As a result of the cross-border merger through the acquisition of all the assets of Investment III B.V., by PGE Energia Ciepła S.A., registered in the Companies Register of the National Court Register on 4 September 2018, PGE Energia Ciepła S.A. on the same day acquired 4,807,132 shares in the Company.
Net profit (in PLN thousand) 101 339 149 156 141 735 168 490 72 868 69 284 98 314 92 962 103 466 47 547
Dividend (in PLN/share) 2.70 6.58 6.25 - - - 4.41 3.5 3.5 2.05
Number of shares (in thousand shares) 14 900 14 900 14 900 14 900 14 900 14 900 14 900 14 900 14 900 14 900
Profit allocated to dividend (in PLN thousand) 40 230 98 042 93 125 - - - 65 709 52 150 52 150 30 545
% profit allocated to dividend 39.7 66 66 - - - 67 56 50 64
Record date 19 September 20 June 10 August - - - 14 August 22 July 22 September 22 September
Date of payment 3 October
9 August 30 August - - - 28 August 10 August 13 October 13 October
zip Dividend Policy (16.04.2019) Download
pdf Dividend Policy (2018-2022) Download
pdf Dividend Policy (2014) Download
xlsx Dividend 2005-2017 Download
December 1990 – Zespół Elektrociepłowni Wrocław (ZEC Wrocław), at its own initiative, requested Poland’s Privatization Ministry to transform it from a state-owned enterprise into a commercial law company.
1 November 1991 – the Company was the first in its industry to officially commence operations as a joint-stock company (S.A.) wholly owned by the State Treasury, under the name of Zespół Elektrociepłowni Wrocław S.A. (ZEC Wrocław S.A.).
Towards the end of 1991 – having reviewed the organizational structure of the Company, its Management Board decided to spin off financially independent companies to carry out support and non-production activities.
Towards the end of 1992 – a new company strategy for the period until 2000, including a strategic action plan, the Company’s mission and an investment and upgrade programme, was developed. Letters of Intent were signed by ZEC Wrocław S.A. with Electricité de France (EDF) and Belgium’s Tractebel. As a result, a Company privatization plan involving foreign investors was jointly developed.
Unfortunately, the process was discontinued due to changes introduced to the Polish Privatization Act. Repeated changes of government hindered privatization.
January 1997 – the Minister of the Treasury assumed ownership of our Company as part of a reform.
July 1997 – the new Labour Code took effect and the Company’s organs requested the Minister of Industry and Trade to resume the privatization procedure.
July 1997 – a great flood, which lasted from 10 July until the end of the month in Wrocław, got in the way of the Company’s privatization plans. Water flooded the plant. Once the damage had been repaired and production resumed, work on the Company’s privatization continued and it was taking shape ever more clearly.
6 July 1999 – the Minister of the Treasury approved the plans to privatize ZEC Wrocław S.A. on the Warsaw Stock Exchange.
3 September 1999 – an agreement was signed with the brokerage house Dom Maklerski Banku Zachodniego to manage an issue of ZEC Wrocław S.A. shares.
26 September 1999 – the Company adopted a new name:
ZESPÓŁ ELEKTROCIEPŁOWNI WROCŁAWSKICH KOGENERACJA SPÓŁKA AKCYJNA
and its abbreviated versions:
ZESPÓŁ ELEKTROCIEPŁOWNI WROCŁAWSKICH KOGENERACJA S.A. or KOGENERACJA S.A.
30 September 1999 – an application was filed with the Polish Securities and Exchange Commission in Warsaw to approve ‘A’ series shares of KOGENERACJA S.A. for public trading.
31 March 2000 – the Polish SEC approved the shares for public trading.
26 May 2000 – the Company debuted on the Warsaw Stock Exchange. The issue debuted at PLN 52 per share, whereas the subscription price had been PLN 49.
28 June 2000 – the first Annual General Meeting of KOGENERACJA S.A. was held.
August 2000 – the process of signing agreements began for the transfer of shares held in KOGENERACJA S.A. by the Treasury to eligible Company employees free of charge.
November 2000 – ‘B’ series shares were issued, to investors only.
IPO Prospectus
pdf Listing of ‘A’ series shares (PL version) Download
pdf Listing of ‘B’ series shares (PL version) Download
Press room Career Tenders Contact (Polski) Polityka prywatności
© KOGENERACJA S.A. All rights reserved
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Sidewalk Toronto Will Feature a Zero-Emissions Thermal Grid
Sidewalk Toronto’s Quayside neighbourhood will get zero-emissions heating and cooling from a “thermal grid” using urban waste heat and geothermal energy with no direct fossil fuel input.
Kerr Wood Leidal Associates Ltd. (KWL) is excited to contribute the design concept for Sidewalk Toronto’s zero-emissions thermal grid in its Master Innovation and Development Plan (MIDP). This will help Sidewalk Labs achieve a neighbourhood vision for Quayside that produces 85% fewer greenhouse gas emissions than a typical downtown Toronto neighbourhood.
The Quayside thermal grid will be a proof-of-concept that could be expanded to a larger scale across the proposed IDEA (Innovative Design and Economic Acceleration) District, allowing the area to tap into a wider range of low-cost waste heat sources. The thermal grid will also be highly-integrated with building systems and an advanced power grid to provide a platform with unprecedented abilities to optimize thermal energy delivery based on the needs of consumers and real-time energy costs.
KWL’s challenge on this project was to develop a thermal grid that emphasized modularity, flexibility and scalability with the ability to utilize multiple low-carbon energy sources. Our solution was a design based on high-efficiency heat pumps distributed across the thermal grid, which allows the grid to respond to each building’s unique thermal requirements. This design approach differs from traditional thermal energy systems, which can experience problems with reduced equipment efficiency and stand-by energy losses.
The thermal grid concept was developed through a collaborative process led by KWL, involving Sidewalk Labs and its partners. This collaborative design process involved advanced modeling and a robust evaluation of a wide range of energy sources and system configurations. As Sidewalk Labs progresses with its plans the thermal grid design will continue to evolve to improve energy efficiency and affordability for consumers.
“Sidewalk Labs is raising the bar for sustainable urban infrastructure, and this project should become a template for other communities seeking to reduce their carbon footprint,” said KWL’s Utility Management Sector Leader Mike Homenuke, P.Eng. “It’s rare to have a developer push for a 100% fossil-fuel free thermal energy system, and it’s been exciting to help Sidewalk Labs develop its pathway to a low-carbon future”, stated Homenuke.
Charlotte Matthews, Director of Sustainability for Sidewalk Labs said of the thermal grid design, "Sidewalk Labs is excited to work with KWL due to their deep experience in designing low temperature thermal grid solutions, since developing an affordable fossil fuel-free thermal energy solution for a climate positive community is a significant challenge. The KWL team brings ingenuity, is responsive to partner input, and is doggedly pursuing lower cost options that deliver equal or better environmental outcomes for Toronto.”
KWL has been recognized with awards for its other innovative thermal energy projects, including the Alexandra District Energy Utility in Richmond, BC and the University of BC’s steam-to-hot-water conversion project. This is in keeping with KWL’s vision: “At KWL we challenge ourselves to create water, community, and energy infrastructure solutions in balance with nature that that make the world a safer, better place for our children.” The Sidewalk Toronto thermal grid also embodies our vision.
Mike Homenuke, P.Eng.
Sector Leader, Utility Management
mhomenuke [at] kwl [dot] ca
For more information on Sidewalk Toronto's Urban Innovations and Sustainability, click here.
Press Release (application/pdf, 0.077Mb)
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ADVANCED INSTRUCTORS INCREASE CLASS ATTENDANCE BY 40%
by Jak Phillips
When the Village Gym decided to only employ Les Mills Instructors who had been through Advanced Training, they increased their class numbers in a matter of months and were also able to pay their Instructors more. Here’s how they did it.
When we all have the same music and choreography as the next Instructor, how can we increase our class numbers and make our timeslot the “must-do” class on the timetable?
We’ve long known that Instructors who attend Advanced Instructor Module (AIM) find that the course absolutely transforms their teaching, and provides them with a whole new skillset to pack out their classes. Now, a case study in the UK demonstrates the undeniable value of Advanced Instructors to clubs.
In September 2017, the 29-site Village Gym chain were debating how they could stand out from their rivals in a competitive market. They were investing heavily in best-in-class products – the UK mid-market operator was well-known for its focus on quality gym equipment and group exercise classes – but there was nothing stopping its rivals from doing the same, and indeed they were.
For the team, there was no point turning to an inferior product ‘just to be different’, while competing on price risked triggering an ugly race to the bottom. So how could they gain the edge?
In the mind of Village Gym Leisure Director Chris Southall, the answer was startlingly simple. He decided to bet big on improving the quality of the one asset his rivals couldn’t possibly copy: his people.
“We’ve always been well-known for our group exercise offering, having made significant investment in bringing world-class Les Mills programs to our clubs, but we were struggling to stand out in a crowded marketplace,” says Southall.
“We always knew the benefits a great group ex offering would bring our clubs in terms of member acquisition and retention, but ultimately the classes are only as good as the people delivering them, so we wanted to ensure there was top-tier quality across our entire Instructor team to ensure we deliver great classes every time and in every club.
“We set ourselves a goal that every Village Gym would have the best Instructors in town – the real rockstars that pack out every class and bring members by the dozen.”
Working closely with his National Fitness Manager Tracy Sollitt, the pair devised an unprecedented plan to put all Village Gym group fitness Instructors through AIM training.
“As group fitness continues to grow in popularity, we’re seeing more and more operators taking a stance on quality as it’s so important to club members,” says Jean-ann Marnoch, Les Mills UK Instructor Experience Director.
“Their expectations of a class are becoming higher, both in terms of the consistency of the content and the quality of Instructor who’s delivering it. The operators able to achieve both and really value and reward the impact a great Instructor can have, realise that it’s a formula for ensuring you’ll never be short of members or Instructors.”
Within three months, average class occupancy had leapt by up to 40 per cent in some clubs, while the rate at its pilot site in Bournemouth went from 78% to 96%. Member retention (up by an average of 5-10% per month) and referrals were through the roof, meaning the better-qualified Instructors could now receive higher rates of pay.
“Even the best sports players in the world need coaches,” says Sollitt. “And it was the same with our Instructors – they were very capable individuals, but we wanted world-beaters. So we drew a line and said from now on we’re only going to employ AIM-qualified Instructors.”
The key goals for Village were to raise the overall quality of its Instructor team and achieve a resultant uplift in member attendances, class occupancy and Net Promoter Score (NPS).
The results were as swift as they were staggering. Within three months, average class occupancy had leapt by up to 40 per cent in some clubs, while the rate at its pilot site in Bournemouth went from 78% to 96%. Member retention (up by an average of 5-10% per month) and referrals were through the roof, meaning the better-qualified Instructors could now receive higher rates of pay.
“Word has got around that we made some bold moves, and for Village it has definitely been a game changer,” adds Southall.
“We were already known for group fitness, but this put us above everyone else in my opinion and I’m delighted to see the impact it’s had on our business.”
For the Instructors themselves, the training had a transformational impact on their approach to teaching group fitness.
It was immediately obvious to Sollitt which Instructors had been through AIM training and which hadn’t.
“The connection between the Instructor and their class is such a standout feature – sometimes you’ll see Instructors take a class and just go through the motions, but AIM makes the penny drop and they instantly ‘get’ the importance of that connection,” she says.
“Instructors go away understanding their strengths, become more self-aware of what they need to improve, and this breeds a confidence and willingness to grow which ultimately results in a consistently heightened experience for club members.”
“The thing about quality is that it’s very much a journey rather than a destination,” adds Southall. “The path is never-ending, but so are the rewards for getting it right.”
To ensure you’re at the top of your game, sign up for Advanced Training. This brand new course launches in the US, UK and Nordics January 2019. Watch this space for updates on when the new training will become available in your country.
CYCLE SCIENCE: YOUR QUESTIONS ANSWERED
We answer questions on the Les Mills cycle programs.
INSTRUCTOR STORY: “I WAS AN ELITE ATHLETE, AND THEN AN ACCIDENT CHANGED MY LIFE IN AN INSTANT.”
Jeremie Hogan opens up about the accident that changed her life.
HOW TO KEEP NEW PEOPLE COMING BACK: YOUR TIPS
We share your advice on looking after new members.
THE FREEZE JUMP KICK, BURPEE TWIST, AND A NEW INNOVATION FOR THE SQUAT TRACK.
We update you on the latest releases, filmed in Shanghai.
CELEBRATING NEW ZEALAND
Images from les Mills January filming 2019.
FLOAT LIKE A BUTTERFLY by Sarah Shortt Learn More
OVERTEACHING? IT’S (UNOFFICIALLY) A THING by Marie Anagnostis
IS FOAM ROLLING WORTH A SPIN? by Mike Trott
REEBOK LATEST RANGE: ‘STEP INTO THE LIGHT’ by Erin Maw
Instructor News View All
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Making Movies, Bilingual Rock Band from Kansas City, to Open for Los Lobos This Cinco de Mayo in LA
By: Latino Rebels
This Cinco de Mayo a bilingual rock band from Kansas City will celebrate a milestone of their own—and it involves a band of original Chicano “Rebeldes.”
Making Movies, an AfroLatino-influenced indie rock band currently on a regional tour that has taken them through Puerto Rico, Panama, the Midwest, Southwest and now California, will open for East L.A.’s Chicano rock veterans, Los Lobos, at the Second Annual ‘Los Lobos Cinco de Mayo Fest’ on May 5 at L.A.’s Greek Theatre. (The concert also features Kinky, La Santa Cecilia, and Los Fabulocos.)
The slot will mark a special moment for the quartet, whose new album, “A La Deriva,” was produced by multi-instrumentalist, Los Lobos’ Steve Berlin. Berlin was first turned on to Making Movies when the guys opened up for Los Lobos at their Kansas City show a little more than a year ago. “I was like, ‘Holy s**t, what the hell’s going on here?’ So, as a band, we were knocked out, and then I sat there for the whole show. I was riveted.” Berlin told KCUR.
Led by brothers Enrique and Diego Chi (singer/songwriter/guitarist and bassist respectively)—and made complete by percussionist Juan Carlos Chaurand, and drummer Brendan Culp, Making Movies formed in 2009. Their do-it-yourself ethos and striking live show has taken the band across the United States opening for respected artists including Ozomatli, Los Lobos, Neon Indian, Cursive, Mariachi el Bronx and Delta Spirit.
In recent weeks, they’ve been compared to Astro, Devandra Barnhart, Animal Collective, and My Morning Jacket. They also recently beat out four indie rock bands from Spain, Puerto Rico, Russia, and Japan to win MTV Iggy‘s “Artist of the Week.”
Amidst the acclaim, Making Movies still elicits surprised reactions from those who stumble upon them. Recently, while playing the growing ‘Middle of the Map’ fest in Kansas City, a local journalist noted the following comment from an “out-of-towner” in the audience: “I can’t believe this band is from Kansas City.”
We believe it. In fact, these young Rebeldes seem to be taking their AfroLatino sound to places one wouldn’t naturally equate with Latinos.
In September, they’ll headline the Northwest Arkansas Hispanic Heritage Festival, which, this year, has a special theme honoring the country of Panama. Watch Univision Arkansas’ interview with the band in regards to the festival here:
But that’s not all. The band is an avid supporter of the Dream Act (check out Tormenta, a song they wrote for Dreamers in 2010), and last year, they co-founded a weeklong music camp for kids in underserved areas of Kansas City. Called M.U.S.I.C.A, the camp is fully booked for this summer.
As for the business of their music, “A La Deriva (adrift),” is rhythmically adventurous, lyrically substantive, and melodically sensuous—a progressive Latino sound. The concept album, which tells the story of a family falling apart through lyrics that explore an abusive relationship and how it effects multiple generations, is available on iTunes or Spotify.
You can listen to the single “Cuna de Vida” here.
How I Made It: Making Movies
PREMIERE: Lyric Video for Making Movies' Poignant…
PREMIERE: Austin Indie Band Como Las Movies Releases…
One response to “Making Movies, Bilingual Rock Band from Kansas City, to Open for Los Lobos This Cinco de Mayo in LA”
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Afro-Colombian Environmental Activist Francia Márquez Survives Attack from Armed Men
By: Amanda Alcántara
Francia Márquez. (Image via Goldman Prize)
On Saturday May 4, armed men opened fire at a group of environmental activists in Santander de Quilichao, Colombia. Afro-Colombian environmental activist Francia Márquez was among those in the targeted group.
Márquez is one of the leading voices of the environmental rights movement. She was awarded a Goldman Prize recognizing her work in 2018.
“This unfortunate situation we had to go through has been one of many situations that leaders in the country have to deal with,” Márquez reportedly said in President Iván Duque who said it was a “cowardly attack.”
“We don’t want to continue sacrificing our lives and we want to continue walking peacefully in our territories without fear for our lives,” she added.
Duque has been heavily criticized for actively attempting to undo the 2016 peace accords.
“This is a humanitarian crisis. We want to share our concerns particularly with politicians who have spoken openly about undoing the peace accord because that would mean returning to violence,” Luis Fernando Arias, Secretary General of the National Organization of Indigenous Peoples of Colombia, said during a July 2018 Washington, D.C. hearing where activists sought support from the U.S. to uphold the peace accords.
Other activists, including Carlos Rosero and Clemencia Carabalí, were also with Márquez. The armed men allegedly launched a grenade at the group.
Márquez explained on Twitter that she was in the region hoping to meet with the government that day following local activism efforts, or “Mingas”—a Quechua word that means “collective organizing.”
Como pueblo negro del Norte del Cauca estabamos preparando una reunion para los diálogos con el Gobierno en el marco de los acuerdos con La Minga y fuimos atacados con armas y granadas por hombres armados, tenemos dos hombres de la UNP heridos.
— Francia Márquez Mina (@FranciaMarquezM) May 4, 2019
Márquez also took to Twitter to denounce the lack of governmental support when it comes to protecting activists, saying that it is time to end the “politics of death” for one that “guarantees life and peace.”
Ya es hora que el presidente @IvanDuque se disponga a cambiar la política de la muerte por una política que garantice la vida y la Paz a todos los colombianos. https://t.co/KBTOV4kyda
Some have shown their support for Márquez and those present, including activist Rigoberta Menchú.
Mi profundo rechazo al atentado de esta noche en el Cauca, Colombia. Expreso mi total solidaridad con @FranciaMarquezM y sus compañera/os. ¡ No más violencia contra las y los defensores de derechos humanos en #Colombia ! https://t.co/6cKOCpKeGD
— Rigoberta Menchú Tum (@RigobertMenchu) May 5, 2019
In 2018, 155 human rights activists were assassinated in the country. Many of those targeted work directly with Afro-Colombian and indigenous communities.
Amanda Alcántara is the Digital Media Editor at Futuro Media. She tweets from @YoSoy_Amanda.
El Grito: Violence in Colombia Continues to Kill Activists
Colombia FARC Negotiators Say They Are Taking Up Arms Again
UN Says 'Staggering' Deaths of Rights Activists in Colombia
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More From Kenya
More Songs From Kenya
Songs in the Kikuyu Language
Articles about Kenya
Countries and Cultures in Africa
Kana ka Nicola
Songs & Rhymes From Kenya
Faith sent me this song and said it's... in the Kikuyu language of the Agikuyu people of Central Kenya. About the fear of a child towards a little frog. It is a tongue twister as well.
Children's Song
(Kikuyu)
Kana ka Nicola,
kona kora kora,
Nako kora kona
kana ka nicola, kora.
Nicole's Child
Nicole's child,
Sees a frog and runs.
And when the frog sees
Nicole's child, it too runs.
Meanings of words in order as they appear:
Kana - child
ka - belonging to
Nicola - Nicole
kona - sees
kora - frog
kora - runs
Nako - and
Many thanks to Faith for contributing this song.
Ni wega!
Can Anyone Help with the Lyrics to the Kenyan Song “Love Peter Love”?
We're trying to learn the lyrics to the Kenyan song, “Love, Peter Love”. You can hear the song in the video below at 2:52... Can anyone help us with the lyrics? Part of it seems to be in a different language. Please also let us know if you can identify the language and/or translate it. [...]
Does Anyone Know a Song called Moja Numba?
Vivian wrote asking about the song "Moja Numba".... Hello, I have heard a song called Moja Numba, which I believe is Swahili. It was recorded by M'EarthTones. I contacted them, but even they weren't able to tell me the origin. I'd like to know what the words are and what [...]
Free Online Language Dictionaries
While I have this link at hand, I'd like to recommend www.freedict.com. It's a site devoted to free online language dictionaries. You can translate between English and the following languages: Afrikaans Danish Dutch Finnish French Hungarian Indonesian Italian Japanese Latin Norwegian Portuguese [...]
Mama Lisa's World News and Multimedia Features
A significant part of the Mama Lisa sites is a large collection of songs and nursery rhymes from around the world. We currently have about 750 songs from around 90 countries and cultures. When you consider how many languages there are in those cultures – that's a lot of information! In order [...]
Hatsumode – Visiting the Temple for the New Year in Japan
Ayako Egawa wrote from Japan about the New Year's tradition called Hatsumode. Here's her letter that I received on New Year's Day... Happy New Year! In Japan, the new year holiday is our biggest holiday and we have lots of customs as part of the new year celebration. One of the popular traditional [...]
Bastille Day in France
By Monique Palomares Bastille Day takes place on July 14th in France.It's known as “le 14 juillet” (the 14th of July) in French. It commemorates the storming of the Bastille on July 14, 1789, and the celebration of the Federation and the union of the nation exactly one year later in [...]
Weddings & Marriage in France
By Monique Palomares Weddings & Marriage in France Before the Marriage: Often before the wedding, the fianc has a bachelor party with his friends. In French, “to have a bachelor party” is directly translated as “to bury life as a boy”. For women, it's a more modern idea to [...]
Mama Lisa's Animal Poems Book
201 Poems & Songs, 390 Pages, with Links To Recordings
Lions, tigers and bears! Oh, my! In this collection, you'll find poems about those animals as well as clams, microbes, and even a pirate's parrot!
This is our biggest book yet, featuring over 200 animal rhymes, poems, fables, tongue twisters, and even some songs.
All of the songs, rhymes, and poems in this book include links to web pages where you can listen to recordings!
You'll find 201 poems and songs, including:
• The Bear Went Over the Mountain
• How The Camel Got His Hump
• The Purple cow
• The Blind Men and The Elephant
• The Unfortunate Giraffe
• The Ambitious Kangaroo
• The Cooties and the Bedbugs
• The Envious Lobster
• The Owl and the Pussy-Cat
• The Dog and The Shadow
• The Old Hen She Cackled
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Manchester Security, Conflict & Peace (2)
Manchester Political Studies (1)
You are looking at 21 - 23 of 23 items for :
masculinity x
Sociology x
User-accessible content x
Unequal choosing
Bridget Byrne and Carla De Tona
Archer and Francis 2007). There has also been some interesting work on questions of race, ethnicity and gender. This includes work on racialised masculinities and the ways in which gender and sexuality interact with race in producing different learning cultures and opportunities (see Mac an Ghaill 1996, Archer 2003). This section has outlined the approach to class and race to be used in this book and the next will focus specifically on the literature 25 All in the mix concerned with school choice, arguing that there has been a tendency (with some exceptions) for this
in All in the mix
Schooling fears
masculinity’ (Williams et al. 2008). In Fiona’s account, both the parents and children seem to be feeling ‘vulnerable’. Certainly the language of fear was common among parents. This can be seen in Sharon’s desire to keep her daughter safe at home: If I had my ultimate choice I would wrap her up in cotton wool and teach her at home. […] Because I’m just terrified of her going to these big schools and the things that gone on in them and you know. My worst fear, and I don’t know why because it never happened to me personally but [….] my worse fear is the bullying point of view
Fear and loving in the west of Ireland
The blows of County Clare
Jeremy MacClancy
, masculinities and staying “behind” in rural Ireland’, Sociologia Ruralis, 41, 220–36. MacHale, Des 2002 Irish Wit (London: Prion). Mattar, Sinéad Garrigan 2004 Primitivism, Science and the Irish Revival (Oxford: Oxford University Press). McMahon, Naoimh 2005 ‘Biodynamic farmers in Ireland. Transforming society through purity, solitude and bearing witness?’, Sociologia Ruralis, 45, 98–114. O’Brien, Edna 2002 In the Forest (London: Weidenfeld and Nicolson). O’Dalaigh, Brian (ed.) 1998 The Strangers Gaze. Travels in County Clare 1534–1950 (Ennis: Clasp Press). Peace, Adrian 2005
in Alternative countrysides
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New York City - Madrid,
New York City - MAD,
Getting around Madrid
#inspiredby #Madrid
City map Madrid
Madrid: Majestic architecture and royal boulevards
One of Europe’s largest – and loftiest capitals – Madrid is often overlooked in favour of Spain’s coastal cities and the former Moorish strongholds of Andalucia. But in many ways, all things still point towards the grand metropolis, which remains a cultural, artistic and economic hub. Once the centre of an empire that gripped the Iberian Peninsula and spread in conquest through the Americas, Madrid is full of grandiose architecture befitting the 16th and 17th centuries’ preeminent global power.
Things still revolve around the wide regal boulevards leading to Plaza Mayor and the labyrinthine districts surrounding it such as La Latína and Chueca. But efforts to revitalise areas beyond the centre have meant that several exciting barrios on the fringes are now worthy of attention too.
Book now – Madrid
Top 10 sights in Madrid
Ruiz de Alarcón 23
Mon-Sat 1000-2000
Sun 1000-1900
With a comprehensive collection of European art from the Middle Ages through to the 19th century, Prado is regarded as the most important museum in Spain.
Paseo del Prado 8
Mon 1200-1600
The sum of several Barons of the name Thyssen, this collection includes masterpieces by Monet, Picasso and Carvaggio. Visiting exhibitions tend to be top quality.
Plaza de Independencia
Once the royal gardens, this huge immaculate park in the centre of Madrid is a place for picnics and romantic strolls. Don’t miss the gorgeous Galápagos fountain.
Santa Isabel 52
Wed-Mon 1000-2100
The national museum for 20th-century art, the bold and compelling collection is dedicated to Spanish artists such as Picasso and Salvador Dalí.
Calle Bailén
Built in the 18th century, the spectacular palace is full of art, tapestries and antiques. The Royal Armoury and Puerta del Moro gardens are notable treats.
The central square and nearby Puerta del Sol give a taste of what Imperial Spain was like at its height of pomp. The surrounding areas are full of tapas bars and outdoor cafés.
Plaza de Picasso 1, Buitrago del Lozoya
Tue-Fri 1100-1345 and 1600-1800
Sat 1000-1400 and 1600-1900
Based on an eclectic range of items from ink sketches to ceramics, this collection was given by Picasso to his barber, Eugenio Arias, and provides some insights into their long friendship.
Convento de las Descalzas Reales
Plaza de las Descalzas
Tues-Thurs and Sat 1030-1230 and 3-5:45pm
Fri 1030-1230
Emperor Charles V’s daughter opened this convent in the 16th century. It features the masterful tapestry by Rubens, ‘Triumph of the Eucharist’.
Calle San Mateo 13
Tue-Sat 0930-2030
An impressive range of artefacts and paintings can be found here, including Alenza and Goya, inside a quaint 19th-century townhouse setting.
Museo Cerralbo
Calle Ventura Rodríguez 17
Thu 1700-2000
Founded by the Marquès de Cerralbo in the late 19th century, this fascinating museum house contains paintings, archaeological finds and opulent furnishings.
Spain is one of the most popular holiday destinations in Europe. Endless beaches, brilliant sunshine and azure waters draw beach lovers to the Mediterranean coast, and the Balearic and Canary Islands. But visitors also flock to see the historical architecture of cities such as Madrid, Barcelona, Valencia, Leon, Seville and Segovia.
If you want to experience the real Spain, don’t go to bed too early. In these parts, people stroll the city squares and dine out late into the night.
Spain accounts for roughly four-fifths of the Iberian Peninsula, with Portugal, Andorra and Gibraltar occupying the remainder. In the northeast, the Pyrenees form a natural frontier to France. The state territory also encompasses the Balearic Islands (Mallorca, Menorca, Ibiza and Formentera) located southeast of Barcelona, in the Mediterranean, and the Canary Islands off the west coast of Africa. Ceuta, Chafarinas, Melilla and Ladu are tiny Spanish exclaves in North Africa, relics of the former Spanish Empire.
Spain is a mountainous country. The Pyrenees extend for 400 kilometers from the Basque Country in the northwest to the Mediterranean. Some peaks rise more than 3000 meters above sea level; the highest elevation here is the Pico de Aneto at 3404 meters above sea level. The country’s interior consists of a vast plateau, the Meseta, which is intersected by a number of mountain ranges.
In the north and northwest, the Meseta is bordered by the Cantabrian Mountains and the Iberian Mountains, and in the South by the Sierra Morena, beyond which lies the Guadalquivir Valley. Galicia’s mountainous landscape runs along the jagged Atlantic coast. The extreme south is also mountainous; the Sierra Nevada southeast of Granada belongs to the Betic Cordilleras, which run parallel to the Mediterranean and include the highest mountain on the Spanish mainland, the Mulhacén (3481 meters above sea level). The highest elevation on Spanish territory is the Pico del Teide (3718 meters above sea level) on Tenerife.
Spain has just under 5000 kilometers of coastline. The Mediterranean coast extends from the French border to the Rock of Gibraltar. The Strait of Gibraltar connects the Mediterranean Sea and the Atlantic Ocean and divides Spain from North Africa.
Population: 46.33 million (2017)
Capital: Madrid.
The official language is Spanish (Castellano, Castilian). In the Autonomous Communities of the Basque region, Galicia, Catalonia, Valencia, Navarra and the Balearic Islands, the relevant regional languages are also used as second official languages according to the Statutes of Autonomy. In tourist areas, English and German are commonly spoken foreign languages.
220 V, 50 Hz (sometimes 110/125 V in older buildings in smaller places)
1 euro = 100 cents
Currency sign/abbreviation: €, EUR (ISO code). Banknotes are available in the values 5, 10, 20, 50, 100, 200 and 500 euros, coins, in the nominal values 1 and 2 euros, as well as 1, 2, 5, 10, 20 and 50 cents.
a) several regional public holidays also exist.
b) it is usual for public holidays, which fall on a Sunday, to be substituted by work-free days on subsequent weekdays.
* not in all parts of the country
Año Nuevo (New Year’s): 1 January 2020
Epifanía (Epiphany): 6 January 2020
Día de San José (St. Joseph’s Day): 19 March 2020*
Jueves Santo (Maundy Thursday): 9 April 2020*
Viernes Santo (Good Friday): 10 April 2020
Domingo de Resurrección (Easter Sunday): 12 April 2020
Día del Trabajo (Labor Day): 1 May 2020
Asunción de la Virgen (Assumption Day): 15 August 2020
Fiesta Nacional de España (Spanish National Day): 12 October 2020
Fiesta de Todos los Santos (All Saints’ Day): 1 and 2 November 2020*
Día de la Constitución (Constitution Day): 6 December 2020
La Inmaculada (Feast of the Immaculate Conception): 8 December 2020
Navidad (Christmas): 25 December 2020
Viernes Santo (Good Friday): 2 April 2021
Domingo de Resurrección (Easter Sunday): 4 April 2021
The Madrid metro is as expansive as you’d expect – more than 200 stations and counting – with a modern, efficient network, and relatively cheap. It runs until after 1am. The buses are frequent and wide-reaching, too (www.ctm-madrid.es). A Madrid Tourist Pass covers local trains, buses and the metro and lasts for a week (tel: 902 444 403; www.metromadrid.es).
Hailing a taxi isn’t too tricky in Madrid, and they’re not too pricey. If you see a green light atop the vehicle, it’s free. To book ahead, try Teletaxi (tel: 91 371 2131; www.tele-taxi.es).
Feel the rhythm: flight attendant by day, flamenco dancer by night
Flamenco in Madrid – for Ann, there could be nothing more uplifting and fulfilling. Follow the Lufthansa flight attendant and flamenco dancer on her journey through Madrid’s lively streets and flamenco bars.
The #inspiredby series takes you on a trip around the world. Experience the world from the perspective of artists, musicians, athletes and our very own crew, whether at work or play! See what impact and meaning traveling has for each of these individuals and let their stories inspire you.
http://youtube.com/lufthansa/inspiredby
Nightlife in Madrid
As with elsewhere in Spain, things don’t get going until late in the night – after 11pm and often much later. The nightlife can seem
a tad more elegant than in other cities, but the outdoor tapas bars in hip barrios cater to those after a few beers and a chat.
Calle de los Cañizares 10
Frequented by tourists and locals alike, this tavern-style venue is much loved for its traditional flamenco.
Plaza del Ángel 10
The elder statesman of Madrid’s live music venues, Café Central has offered jazz and rock performances since 1982.
1862 Dry Bar
Calle Pez 27
Serving perhaps the best cocktails in Madrid, 1862 is an essential stop in the cool Triball area.
Tipos Infames
San Joaquín 3
In the once grim but newly hip Malasaña barrio, this part-bookshop part-wine bar has proved a real hit.
Calle Tetuán 12
For a brief history lesson, visit the ancient tavern where Pablo Iglesias founded the Socialist Party in 1879.
Restaurants in Madrid
Although the culinary zeitgeist is currently with the Basque country and Catalonia, Madrid remains a gastro pioneer.
The proud capital offers the finest dining as well as both contemporary and classic takes on the south’s beer-and-tapas culture.
Casa Lucas
Cava Baja 30
The originator of cocina creativa (creative cooking), Casa Lucas is still going strong after nearly two decades.
Olé Lola
The ostentatious and playful interior of this stylish restaurant is matched by the inventive food, bringing tapas to the 21st century.
Cava Baja 38, La Latina
With a wide selection of superb Spanish wines and great tapas, this is a popular tavern-style restaurant.
Casa Ricardo
Calle Fernando el Católico 31
Despite looking rather fancy, this 70-year-old restaurant offers homely cooking and traditional dishes such as bull’s tail.
La Sanabresa
Calle Amor de Dios 12
There aren’t so many casas de comida (traditional eateries) left in Madrid these days. This one still offers a delicious set menu of soup, meat course and a drink.
Reyes Magos (Epiphany)
Venue: City centre
Marked by a procession of the ‘the kings’ with commercial floats, watched by thousands of children and their parents as they line up along Calle Alcalá to watch the annual cabalgata (parade). There are lots of elaborate floats and the riders traditionally throw sweets to the children. The occasion ends with a big family dinner, and the giving of presents the following day.
Madrid Carnival
Venue: Various streets in central Madrid
The week before Lent sees the Madrid version of the traditional Mardi Gras Carnival, featuring parades, extravagant costume parties and flamboyant masks. The highlight is a tradition called ‘The Burial of the Sardine’, in which participants, dressed in black cloaks and hats, proceed through the streets with a coffin containing an effigy of a dead sardine.
Semana Santa (Holy Week)
Solemn religious processions and services to mark Holy Week, the week leading up to Easter Sunday.
Madrid Marathon
Venue: Streets of Madrid
The annual Madrid Marathon is raced on an urban course which usually includes Puerta del Sol, Plaza Mayor and Palacio Real – all good viewing points from where to watch the day’s event. The event attracts approximately 13,000 runners each year from about 60 different countries.
Madrid Pride
The four day festival is arguably one of the best in the world and culminates in a parade through the Retiro, Sol and Casa de Campo districts, with other events concentrated in the Chueca district.
Festival Flamenco
One of the nation’s best Flamenco dancing competitions, drawing competitors from all over the world. It is usually accompanied by classical guitar concerts. Taking place at some of Madrid’s top venues, such as La Casa Encendida and the Teatro Canal de la Comunidad de Madrid, the Caja Madrid Flamenco Festival brings you the best in flamenco excitement and beauty.
Nochevieja (New Year's Eve)
Venue: Puerta del Sol
Crowds gather to eat grapes and drink champagne. Much of the action is centred on Puerta del Sol as revellers wait for the the clock on the Real Casa de Correos building to strike midnight.
From elegant converted houses to massive palatial properties, Madrid offers an abundance of hotel options.
An essential stopping point for young travellers, the city also has plenty of lower-priced accommodation.
Carrera de San Jerónimo 34
With an open-air rooftop pool – ideal for the sizzling summer heat – and 96 stylish rooms, Urban is the decadent choice.
Room Mate Alicia
Calle Prado 2
This charming 34-room hotel was designed by Pascua Ortega and features impressive light installations.
Calle Barquillo 21
A 19th-century palace on the outside, this curious city hotel is hip and contemporary on the inside.
Calle Pizarro 14
First built in 1850, this small tidy bed and breakfast ensures that guests feel at home.
more hotels at Booking.com
Climate & best time to visit Spain
The Spanish climate varies from region to region, spanning moderate in the north to Mediterranean in the south, and even subtropical on the Canary Islands.
The best times to visit Spain are generally in the spring and the fall, when temperatures are agreeable. In most parts of the country, it is very hot at the height of summer, but sea breezes on the coast keep it bearable; the interior is best avoided in July and August. The climate on the Atlantic coast and in all of Galicia is pleasant even in summer. In winter, you can enjoy winter sports in the Pyrenean Mountains or agreeably warm days on the south and southeast coast, as well as on the Canary Islands.
Climate and best time to visit Madrid
Spring and autumn are the popular choices for visiting Madrid, as the summer months – particularly July and August – are almost unbearably hot. It’s also rather cold in winter, though there’s enough sun during the day to be generally pleasant; there’s also a plethora of heart-warming seasonal dishes to choose from, which tourists usually miss out on. May is a safe bet, with reliably good weather, and a string of festivals to enjoy, including the capital’s biggest celebration, the Festival of San Isidro – the patron saint of Madrid. There are several music and arts festivals, including a documentary film festival, and any number of street festivals.
Jan 64.4 °F 14 °F 46.4 °F 33.8 °F 78 % 45 mm 8 4.6 h
Feb 71.6 °F 15.8 °F 51.8 °F 35.6 °F 70 % 44 mm 8 5.7 h
Mar 78.8 °F 24.8 °F 57.2 °F 41 °F 61 % 37 mm 7 6.4 h
Apr 86 °F 26.6 °F 64.4 °F 44.6 °F 58 % 51 mm 7 8.0 h
May 91.4 °F 32 °F 69.8 °F 50 °F 54 % 44 mm 7 9.5 h
Jun 100.4 °F 39.2 °F 78.8 °F 57.2 °F 49 % 27 mm 5 10.8 h
Jul 102.2 °F 46.4 °F 86 °F 62.6 °F 40 % 12 mm 2 12.3 h
Aug 100.4 °F 44.6 °F 84.2 °F 62.6 °F 42 % 12 mm 1 11.4 h
Sep 96.8 °F 37.4 °F 77 °F 57.2 °F 52 % 30 mm 4 8.6 h
Oct 86 °F 30.2 °F 64.4 °F 48.2 °F 66 % 51 mm 6 6.6 h
Nov 71.6 °F 26.6 °F 53.6 °F 41 °F 73 % 58 mm 7 5.2 h
Dec 62.6 °F 15.8 °F 46.4 °F 35.6 °F 77 % 52 mm 8 4.5 h
year 102.2 °F 14 °F 64.4 °F 46.4 °F 60 % 463 mm 70 7.8 h
Since June 2017, EU citizens traveling within the EU, and also in Iceland, Norway and Liechtenstein have been able to use their cell phones and surf the Net without incurring any extra charges: In other words, customers pay the same price for phone calls, text messages and data volume as they do at home. Restrictions do apply to the constant use of SIM cards abroad, however, and caps may be set on data packages.
For full details, contact your mobile telephony provider in your country. Travelers using a SIM card from a non-EU state do not benefit from the new arrangement.
Calle Serrano has lots of high-street shops and designer labels, while there are plenty of fashion boutiques on nearby streets such as Calle Goya. For vintage clothes and hipster destinations, head to Malasaña and Triball.
The only iron-structured market surviving today, San Miguel is Madrid’s most famous food market situated in the historical centre, with locally grown produce. Sunday’s Rastro Market on Ribera de Curtidores is a must, with dozens of stalls sprawling into the surrounding streets.
Spain’s leading chain of department stores, Corte Inglés has its flagship store in Madrid and is one of the biggest malls in Europe.
It is polite in Spain to shake hands in greeting. The usual courtesies should be observed. If you are invited to someone’s home, your host will appreciate a small gift. Flowers are given only on special occasions.
Casual dress is appropriate almost everywhere, although some hotels and restaurants require men to wear a jacket and tie; evening dress is only required for particularly formal occasions. Swimwear belongs without exception on the beach.
A smoking ban applies in all public institutions, on public transportation, in telephone booths and in rooms containing ATMs, as well as in children’s playgrounds and schoolyards. The smoking ban also applies to all bars, cafés and restaurants. Smoking areas inside bars and restaurants are no longer permitted.
Tips are generally included in hotel and restaurant bills. It is nevertheless usual to leave a small tip for the service staff. Porters receive a small sum per item of luggage. The usual amount tipped in restaurants is between 10 and 15 percent. When the waiter brings your change, you leave some as the tip. It is considered extremely rude, however, to leave two- or five-cent pieces. When tipping your taxi driver, simply round up the fare.
Emergency telephone number: 112
Lyme disease, TBE (tick-borne encephalitis) and leishmaniosis are all diseases which are passed on by ticks and mosquitoes and also occur in Spain. Clothing that covers the skin and insect repellents provide protection.
Hepatitis A and hepatitis B occur all over Spain. A hepatitis A vaccination is generally recommended. Visitors planning an extended stay and close contact with the local population, and generally with children and young people, should also have a hepatitis B vaccination.
Measles and whooping cough occur in Spain. Before traveling to Spain, visitors should definitely check whether their vaccinations are up to date and if necessary, get a booster shot.
Epidemic outbreaks of meningococcal meningitis occur in Spain. Visitors should seek protection by getting a vaccination and avoiding large crowds. Children and young people, in particular, should be vaccinated. According to the latest recommendations, the vaccination applies as required travel vaccination for extended stays for certain groups of people (teenagers, school and university students). Visitors should consult their physician regarding the need for vaccination in the light of recommendations in the country of destination.
Dr. Eberhard, Ulrich
c/Joaquin Montes Jovellar 4
Tel. +34-91-564-3887
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Talks that are specifically aimed at setting the young hearts of the Church on fire for Jesus Christ!
Spanish - El Relativismo: ¿nos afecta?
Chris Stefanick
Chris Stefanick es un reconocido autor y conferencista internacional, dedicado a inspirar a las personas a vivir una fe viva y contagiosa. En esta charla, aborda el tema del Relativismo con honestidad, validez lógica y con el humor que lo caracteriza. Ofreciéndonos con esto una perspectiva del estatus de la moralidad actual. Definitivamente es un tema importante y polémico, incluso el Papa Bene... [More]
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The Virtue Chronicles – The Saintly Outlaw - Book
Andrew Perry likes history, but he never expected to experience it firsthand. But that’s what happens when he meets the unusual Eve Virtue, a direct descendant of the explorer and entrepreneur Alfred Virtue. Eve has uncovered Alfred Virtue’s greatest secret: the mysterious Radiant Stone. Before Andrew knows it, the two of them are in twelfth-century England, caught up in the adventures of the ... [More]
Letter to the Youth by Pope John Paul II
Dr. Christopher Blum
Click Here for a PDF of Selections from Letter to the Youth, by Pope John Paul IIPope John Paul II's papacy is marked by the ways he engaged with and was loved by the youth. Scores of young people were drawn to him from around the world by a magnetism that continues even today, in his sainthood. In his letter to the youth of the world, John Paul offers young people his encouragement to respond to... [More]
Average Rating: 4.00 based on 1 ratings
YOUCAT Bible
The newest title in the internationally best-selling "YOUCAT" series for youth and young adults, this outstanding Bible features the creative elements of the best-selling YOUCAT youth catechism and the DOCAT social teaching handbook. It's filled with engaging photos, clever and fun illustrations by YOUCAT's award-winning designer, insightful sidebar quotes from great thinkers, Catholic saints and... [More]
Spanish - Creados para la Grandeza
Leah Darrow
“El testimonio de Leah Darrow es un poderoso ejemplo de la misericordia de Dios.” -Jason Evert, fundador de Chastity Project “Leah Darrow tiene un verdadero don para compartir una visión del mundo centrada en Cristo que es relevante, convincente y atractiva” -Curtis Martin, fundador de FOCUS Leah Darrow era modelo en Nueva York y concursó en el programa America’s Next Top Model. ... [More]
Spanish - ¿Quién es Jesús para ti?
Fr. Michael Schmitz
El Padre Michael Schmitz es un reconocido presentador y guía espiritual de jóvenes. En esta charla, nos habla del importante tema de la existencia de Dios. Usando su bien conocido sentido del humor y echando mano de argumentos filosóficos sólidos, el P. Mike nos demuestra las profundas implicaciones que tiene para nuestras vidas la respuesta que le damos a Jesús cuando nos pregunta: ¿Quién ... [More]
Spanish - Beato Pier Giorgio Frassati
Fr. Tim Deeter
Pier Giorgio nació en una familia influyente y rica de Turín, Italia en el año 1901. Vivía rodeado de amigos, excursiones, viajes, museos, música y fuertemente involucrado en la política local. Hasta que descubrió que la vida de profunda oración, el servicio a los pobres y el llevar a los demás a una relación con Cristo, le daba a su vida un verdadero sentido, paz y felicidad. Murió a l... [More]
Your Questions, God's Answers
Dr. Peter Kreeft
Click here to read a sample of the book. Peter Kreeft uses Scripture to provide God’s profound answers to the most common and important questions young people ask about the deeper meaning of life, their own identities, overcoming failure and temptation, the mystery of God’s love, and much more. But these are questions asked not just by the young—they are the same questions adults often... [More]
Spanish - De Pandillero A Discípulo
John Pridmore
Él era un rostro reconocido en el Este de Londres. Su ropa era confeccionada a la medida para que pudiera llevar su machete y sus armas. Sus negocios con las drogas lo hicieron millonario. Sin embargo, algo extraordinario sucedió . . . John Pridmore ha compartido su testimonio de conversión en las Jornadas Mundiales de la Juventud y en EWTN. Su historia sobre el poder transformador de Cristo... [More]
The Ultimate Goal: Why I Left Pro Soccer to Answer God’s Call
Sr. Raffaella Cavallin A.V.I.
Sister Raffaella Cavallin, a consecrated lay-person with the Apostles of the Interior Life, shares her inspiring spiritual journey. At the height of her professional soccer career, while attending a parish mission, she discovered that the ultimate goal in life is to become a saint. Sister Raffaella’s story illustrates how holiness and happiness go hand in hand, and that through prayer, the Sacra... [More]
Average Rating: 4.00 based on 18 ratings
DOCAT Study Guide
With the DOCAT Study Guide, you instantly have a flexible Catholic social teaching curriculum that is sure to engage and challenge any youth and become a valuable asset for every priest, teacher, DRE, and youth minister. Featuring full-color images, connections to the DOCAT and the Bible, reflection points, and discussion questions, this study guide will help young people understand the social d... [More]
DOCAT is "revealing the secret" to young people around the world.DOCAT helps young people to know and live Catholic Social Teaching. It's a great, practical follow up to YOUCAT, the hugely popular Youth Catechism, based on the Catechism of the Catholic Church. Drawing on Scripture, YOUCAT, the Catechism, and the Compendium of Catholic Social Teaching, DOCAT shows young people how to work towa... [More]
Our Beautiful End: Exploring the Timeless Mystery of Heaven
The son of a Protestant minister, Matthew Leonard is now an internationally known Catholic speaker, author, and the Executive Director of the St. Paul Center for Biblical Theology. In this presentation, Matthew discusses the nature and role of beauty in life, particularly how it sheds light on the nature of God and assists us in achieving our glorious end, which is heaven itself.
Made for Greatness: Runway Model Turns to Christ
"Leah Darrow's testimony is a powerful example of God's mercy at work." -Jason Evert, founder of Chastity Project"Leah Darrow has a true gift for sharing a Christ-Centered vision that is relevant, compelling, and engaging." - Curtis Martin, founder of FOCUSLeah Darrow was a fashion model in New York City and a reality TV contestant on America's Next Top Model. She now trav... [More]
Emotional Virtue
Sarah Swafford
Drama-free relationships...do they even exist? Today's dating scene is more complicated than ever, especially with social media, texting, and endless pressure of the world's expectations. Learn how to navigate through the confusion and discover the freedom that comes from living a virtuous life. Sarah Swafford is the founder of Emotional Virtue Ministries, and speaks to teens and young adults ab... [More]
The Big Question: God Are You There?
Matt Fradd
Matt Fradd is a highly sought-after Catholic speaker and apologist who speaks to over fifty thousand teens and young adults a year. Matt is a gifted evangelist whose talks are the perfect balance between intellectual depth presented in an understandable fashion and an entertaining style that keeps audiences engaged throughout. Through his passionate and entertaining story, Matt relays how God's ex... [More]
Living Life by Design, Not Default
With so much technology at our fingertips, it's tough not to get swept away in all the noise and clutter. In our society there's often a tendency to live passively by simply "going with the flow." In this talk given at a FOCUS national conference, Fr. Mike Schmitz explains how we need to live an intentionally Christian life within a technological age.
Men, Women, and the Mystery of Love
Dr. Edward Sri
In today's culture we're constantly bombarded with a secular notion of love and intimacy, instead of the kind of love that God intended for his children. In this presentation, Dr. Edward Sri explains how Saint John Paul II teachings of the Theology of the Body can help us prepare for our future marriage, by showing us how to live as selfless, authentic men and women.
Being All In
Eric Mahl
Eric Mahl grew up in the small town of Monroeville, Ohio where he was a standout athlete. He earned a scholarship to play division one football at Kent State University and, in 2005, was signed by the Cleveland Browns. After leaving the NFL, he spent three years working in the world, where he continued his intensive focus on discerning his vocation. After this period of discernment, he sold or gav... [More]
Drawing Close: The God Who Desires You
David Calavitta
WHILE SUPPLIES LAST.David Calavitta has worked in Catholic Youth ministry for the past 13 years, serving as a youth minister in several parishes, as well as a missionary with NET Ministries. In this heart-felt talk given at a Steubenville Youth Conference, David reflects upon the all-important and fundamental truth that we were created out of love by a God who continually seeks to draw us into a p... [More]
Fan or Follower?
Jeff Cavins
In this talk, Jeff Cavins shares how he has come to see that Jesus wants us to surrender every bit of our own comfort to follow Him. There are many fans of Jesus in this world, but we are called to be His disciples. As a young adult, Jeff left the Catholic Church and became a Protestant Pastor for 12 years. After returning to the Catholic Church, he became a nationally known speaker who has helpe... [More]
Patrick Lencioni is the founder of The Table Group and the author of 10 books which have sold over 4 million copies and been translated into more than 25 languages. Additionally, The Wall Street Journal called him one of the most sought after business speakers in America. In this talk given at the FOCUS National Conference, Patrick provides a hopeful yet cautionary lesson about the dangers of livi... [More]
The New Conversation: Changing Hearts & Minds on Abortion
Stephanie Gray
Stephanie Gray is a passionate and uncompromising defender of the Catholic Faith, as well as an advocate for those who cannot speak for themselves. She frequently travels across Canada and the United States speaking on issue related to the humanity of the unborn, utilizing her unique ability to speak to people on either side of a pro-life issue. In this presentation given at a Students for Life c... [More]
The God-Sized Hole
Connor Flanagan
Connor Flanagan is a musician and youth minister who has been actively involved in ministry for the last five years. Connor has spent the last several years traveling the country leading retreats and speaking at both youth conferences and parish events. In this presentation, Connor uses his own personal testimony to show how each one of us has what he calls a "God-Sized Hole" within our own hearts... [More]
Getting Others to Heaven
Noelle Garcia
Believe it or not, we are all called to be leaders. In her typical vibrant and energetic style, Noelle Garcia here shows us how leadership is an important component for propagating the New Evangelization. Noelle shares her early experiences of dealing with insecurity, and how she came to better understand what it means to be a Christian leader. She shows that although we are all sinners, God has g... [More]
Freedom Through Forgiveness
Ken Yasinski
With over 15 years of experience, Ken Yasinski has quickly become one of Canada’s most sought after Catholic speakers. Through clever examples and insightful stories, Ken reveals how each of us can obtain freedom from the burden of our sins through the forgiveness that is readily available in the Sacrament of Confession.
Women Made New
Crystalina Evert
Is it ever too late to start over? In this inspiring talk, Crystalina Evert explains that it doesn't matter what you've done or where you've been; all that matters now is where you go from here. Crystalina has spoken about chastity to hundreds of thousands of people on four continents and is the author of several books including Pure Womanhood and How to Find Your Soulmate Without Losing Your Soul... [More]
All Things Are Possible for God
Fr. Joshua Waltz
As a young man, the last thing Fr. Joshua Waltz ever thought he would be was a Catholic priest. But a series of choices—some bad and some good—ultimately led him to enter the seminary. In this talk, Fr. Waltz shares an incredible vocation story that involves heartbreak, robbers, Europe, and several miracles—all showing that there is nothing more exciting than a life lived for Jesus Christ.
True Beauty & True Strength Complete Package for Leaders
Order by January 8 to get 20% off during our Christmas promotion! Retail Price: 194.95 Sale Price: 155.96 The Complete Package for Leaders includes everything an adult would need to present True Strength and True Beauty to a small group of young men or women: the two DVD sets, both Leader’s Guides, and both Study Guides. Click here for a sample of the True Beauty Leader Guide. Click he... [More]
Add Box Set | $155.96
That Awkward Moment When God Changed My Life
Paul J. Kim
Moving his audiences from laughter in one moment to deep re flection and prayer in another, Paul J. Kim utilizes his many talents to communicate the Gospel to young people in a way that is engaging, entertaining, and altogether inspiring. In this top-notch presentation, Paul uses humor and personal stories to reveal how Christians are beloved sons and daughters of the Father.
Changed Forever: The Sacrament of Baptism
Fr. Mike Schmitz is one of the leading speakers to young people in the Church today. In this presentation, he explains how Christians truly become sons and daughters of God the Father for all eternity through the sacrament of Baptism.Following the presentation, Lighthouse Catholic Youth has provided a bonus segment from Fr. Mike that explains the topics of "Infant Baptism" and "No Salvation Outsid... [More]
How to Save Your Marriage Before Meeting Your Spouse
Jason Evert
Can you divorce-proof a marriage before it begins? In this top-notch presentation, Jason Evert shows us how to build the foundation for lasting love, and reveals how marriage preparation starts before "engagement". Jason Evert has spoken about chastity to more than one million people around the world and is the author of more than a dozen books, including "How to Find Your Soulmate Without Losing ... [More]
Love or Lust?
Jason and Crystalina Evert
Scare tactics, guilt trips, and the climbing teen pregnancy rates don't really inspire anyone to love. In this presentation from Jason and Crystalina Evert, you'll discover the difference between love and lust while getting straight answers about dating, relationships, and sexual purity.
Real Womanhood
Lisa Cotter
In a talk that was given to a group of women at the FOCUS national conference, Lisa Cotter debunks the myths of modern day stereotypical womanhood. Using insights from the late Pope John Paul the second and the heroic example of modern-day saints, Lisa gets to the truth about what it means to be an authentic woman.
How to Date Your Soulmate
Most people have only been told what they're not supposed to do while dating. In this powerful presentation, renowned chastity speaker Jason Evert shows us ten strategies for how to practice courtship without compromise. Tested through real-world experience and rooted in God's plan for the human heart, Jason's wise tips are sure to lead you to greater romantic happiness and fulfillment.
Love Hurts: The Truth Behind Redemptive Suffering
In this presentation, Matthew Leonard focuses on the new idea of love proclaimed by Christ and how it gives meaning to human suffering, penance, and ultimately death. Sounds a bit dark, doesn't it? But it's not! By looking at these issues we'll discover the secret to how we can "Rejoice in the Lord always" just like St. Paul, no matter what happens.
Contemporary Sainthood
Mark Hart
In this incredible double feature, Mark Hart illuminates what it means seek sanctity in the 21st century. In the first presentation, Mark discusses unleashing the power of the Holy Spirit and becoming who we are meant to be: saints. In the second presentation, Mark talks about the dangers of putting human expectations on our supreme God. These two talks will be sure to jump start your spiritual li... [More]
Pier Giorgio Frassati - Booklet
A young Catholic who spent his short life caring for the sick and infirm. A handsome and active young man from an influential family in Turin who dedicated his short life to the care of the poor and the sick and working for social and political reforms. Pier Giorgio Frassati’s generosity was legendary. He often gave the clothes he was wearing to poor people he met who were in need. An open anti-... [More]
Add Booklet | $2.25
Many religions make contrasting claims about Jesus. Even different Christian denominations can’t decide what they believe. So how do we know what’s true? In this talk, Ken Yasinski gets the heart of the issue by looking at what Jesus said about Himself and the impact this has on us.
No Imitations
Chris Stefanick discusses chastity beyond the usual fear tactics and "just say no's." Instead we are offered something to say "Yes" to: health, happiness, authentic relationships, and the love we were made for. Everything else is just an imitation.
Out of stock ETA: to be determined Within every heart is a battlefield between love and lust. In this presentation, Jason Evert discusses the strategies necessary to win the war and uproot the vice of pornography once and for all. Jason is an internationally known Catholic author and speaker. He has spoken to more than one million people around the world and is the author of more than a dozen b... [More]
Fr. Larry Richards
“How do I know what God wants?” Knowing the will of God can be an intimidating topic for people of all ages. In this talk, Fr. Larry Richards, the founder of The Reason for Our Hope foundation, delves into the process of discernment. With personal stories, practical steps, and sound advice, Fr. Larry encourages all of us to dedicate ourselves to living the life that God has planned for us. It ... [More]
The Baseball Priest
Fr. Burke Masters
More gripping than the pull of professional sports, the call to the priesthood reveals the great plans God has for those he has called. In this homily, Fr. Burke Masters tells the story of his journey through baseball, to Catholicism and eventually to the priesthood. In a bonus segment, Major League Baseball all-star Mike Sweeney discuss being the perfect teammate with examples from his time in t... [More]
When people decide to follow Christ, they often experience conversion. In fact many of the saints refer to continuous conversion throughout their lives. In this talk, Mark Hart tells the story of his conversion and encourages us to be made new in Christ.
Power in Prayer
Sr. Mary Gabriel
Listen as Sister Mary Gabriel, Novice Director for the Sisters of Life, speaks to college students about the transforming power of prayer at the Seek 2013 conference presented by FOCUS. Drawing on personal experience and her lively faith, Sister encourages all of us to rededicate ourselves to growing in relationship with Christ through a life of joyful prayer.
Beauty has Saved the World
THIS TALK IS ONLY AVAILABLE AS AN MP3.In this talk, given at the 2012 GLORY Conference presented by Mysterium, Jimmy Mitchell shares the transforming effects of Beauty on the human heart. Speaking to college students gathered from across the country, Jimmy reflects upon the innate desire to reach for and be embraced by the Creator of all that is Good, True, and Beautiful. Interested in bringing... [More]
We Must Go Out: the Sacrament of Confirmation
It is through the Sacrament of Confirmation that a Catholic is fully initiated into the Church. Why then do so many newly confirmed Catholics never come back? In this talk, Fr. Mike Schmitz addresses this concerning trend in the Catholic Church with honesty, energy, and humor. Focusing on the true nature of Confirmation, Fr. Mike challenges ALL Catholics to see this sacrament not as a "graduation"... [More]
Total Yes
THIS TALK IS ONLY AVAILABLE AS AN MP3. Paul George speaks about the radical example of surrender that we find in the Blessed Mother. With deeply moving stories and authentic personal witness, Paul leads the way to a new outpouring of grace in our spiritual lives through a heartfelt devotion to Mary.
Pope Emeritus Benedict XVI considered Moral Relativism to be the most dangerous dictatorship existing in the world today. in this presentation, Chris Stefanick debunks the powerful and epidemic myth of relativism with honesty, relevance, humor, and logical validity, offering a much-needed perspective on the current status quo of morality. "If you only listen to one CD this year, listen to 'Relat... [More]
YOUCAT - The Youth Prayerbook
The internationally best-selling book, YOUCAT - The Youth Catechism of the Catholic Church, explained to young people the meaning of their faith in language, style and design that has appealed greatly to them. Now YOUCAT - The Youth Prayer Book, helps them to live their faith and deepen their spiritual lives.Pages: 176Book Dimensions: 5" x 8"
Uncovering Our Story; Faith and Identity
Mary Bielski
THIS TALK IS ONLY AVAILABLE AS AN MP3. Mary Bielski, a uniquely sincere and relevant witness, shares the truth of our identity grounded in God. With personal testimony and authentic vigor, Mary explains how radically our stories can change when we are introduced to the Person of Jesus Christ.
God of My Past, God of My Future
Recorded live at two of Life Teen's XLT events, Mark Hart and Matt Smith reveal the depth of God's infinite love for each of us, and challenge us to find out what happens when we abandon everything to Him.
Given For You: The Sacrifice of the Mass
Dr. Scott Hahn
THIS TALK IS ONLY AVAILABLE AS AN MP3. Dr. Scott Hahn addresses a group of young people about the depth and drama of the Church's highest prayer - The Holy Mass. Using rich theology and down-to-earth language, Dr. Hahn illuminates the context of the Last Supper through it's inseparable ties the events on Calvary: If the Crucifixion was more than just a Roman execution, then the Eucharist must... [More]
Fr. Michael Schmitz, a renown and beloved speaker and spiritual guide to the Young Church, discusses the all-important topic of God's existence. Armed with his usual repertoire of lively humor and sound philosophy, Fr. Mike reveals the incredible implications of the question which Christ asks all of us: "Who do YOU say that I Am?"
Fr. Damian Ference
THIS TALK IS ONLY AVAILABLE AS AN MP3. Fr. Damian Ference, popular Catholic writer, speaker, and professor at Borromeo College Seminary in Cleveland, shares his insights into the mystery of suffering. With moving personal stories and inspiring conviction, Fr. Damian reveals the depth of divine love as shown by his willingness to embrace the very human experience of suffering.
THIS TALK IS ONLY AVAILABLE AS AN MP3. Have you ever tried to read the Bible but didn’t really know how or where to start? In this talk, Mark Hart beautifully explains how to read, meditate on, and bring to life the Sacred Scriptures through a technique called, "Lectio Divina." Find out how this form of prayer can help you enter into a deeper and more prayerful experience with the Lord.
Why Do Women Do That?
In this talk delivered to a group of college-aged men at the 2011 FOCUS Conference, nationally sought-after speaker Lisa Cotter addresses an important but often overlooked topic — emotional purity. Using Taylor Swift lyrics to emphasize her point, Lisa proposes that emotional purity is essential for authentic love to flourish in any romantic relationship. This talk is perfect for every young ad... [More]
The Scandal of the Incarnation
Brian Kissinger
THIS TALK IS ONLY AVAILABLE AS AN MP3. "And the Word became Flesh, and dwelt among us." At times, we can overlook the real drama of this Truth. In this talk, Brian Kissinger shares the enormous implications of the Incarnation on our lives, and the life we are called to in response to God's most "scandalous" act.
From Love, By Love, For Love
Father Michael Schmitz tackles some of the most difficult topics in the Church today. With compassion, clarity, and humor, he shows that the Church's teachings on contraception and same-sex attraction are rooted in the yearnings for authentic love that is shared by all, who are made in the image and likeness of God.
Get to Know the Mother of God
There’s a little bit about Mary in Scripture. We can glean a bit more from the Tradition of the Church. But where can we go to get the complete picture, to find out about the whole Mary? In an engaging style, Chris Padgett does just that as he walks us through what the Bible has to say about the Mother of God. What has she meant to the Church throughout the centuries, what have the saints told u... [More]
Father Michael Schmitz, the director of Youth and Young Adult Ministry for the Diocese of Duluth as well as the Chaplain for the Newman Center at the University of Minnesota-Duluth, inspires and educates in this talk about the highest form of worship - the Mass. His Newman Center focuses on being fed through the Sacraments as well as study and knowledge of the Church and has thrived under his humb... [More]
YOUCAT: Youth Catechism
YOUCAT is short for "Youth Catechism of the Catholic Church," which was launched on World Youth Day, 2011. Developed with the help of young Catholics and written for high-school age people and young adults, YOUCAT is an accessible, contemporary expression of the Catholic Faith. The appealing graphic format includes Questions-and-Answers, highly-readable commentary, summary definitions of key ... [More]
Add YOUCAT Book | $16.96
What is the meaning of life? Fr. Larry Richards tackles life's biggest question with straightforward, timeless, and often jolting answers. In this one-of-a-kind, life-affirming reality check, he unlocks the mysteries of our existence and opens our hearts and souls to the meaning of life. The Truth will give you concrete answers on how to live.
Blessed Pier Giorgio Frassati - Man of the Beatitudes
Born in 1901 in Turin, Italy into a family of wealth and status, Pier Giorgio enjoyed good friends, hiking and skiing, museums and music, and was involved in political action, He found that deep prayer, service to the poor, and a passion for bringing others to Christ led to a life of purpose, peace, and happiness. Pier Giorgio died at the age of 24 on July 4, 1925. He was beatified on May 20, 1... [More]
St. Philomena - A Saint For Our Times
Though St. Philomena lived approximately 1700 years ago and was only discovered in the catacombs of Rome in the early 1800's, her faithful witness as a young virgin who was martyred for her purity and for her fidelity to Christ speaks powerfully to our culture, and especially to young people. Commonly referred to as a "wonder worker", she has the distinction of being the only saint canonized sole... [More]
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Social inclusion for all young people in Europe!
Youth Express Network (Y-E-N) is a European network of grass-root youth organisations. Our 30 member organisations come from 22 different European countries and work at local, regional, national and European level for the social inclusion of young people. Our main goal is to reach an inclusive society, where young people, their rights, needs and participation are recognised, valued and appreciated. The Network is legally registered in Strasbourg (France). Our Board is pan European (6 volunteers) and our Coordination Office is based in STRASBOURG, France (4 paid-staff).
25 YEARS WORKING ON SOCIAL INCLUSION
Since 1993, Y-E-N organises trainings, study visits, seminars, youth exchanges etc. designed for youth/social workers and young people with fewer opportunities. Y-E-N works using non-formal education on empowerment, access to Social Rights and social inclusion of young people.
We have conducted researches on youth and social related issues and have been trying to be the voice of young people with fewer opportunities in local, regional and international institutions, either by representing them or by supporting them to create and be part of youth councils.
Our network is member of the European Youth Forum (YFJ) and the Conference of International Non-Governmental Organisations of the Council of Europe (COE).
For us, «Express» has two meanings:
- Expression, because we believe that youth have a lot of valuable things to say about social issues today;
- Quickly, because the idea is that if we want social change, we have to start here and now!
Our vision is founded on the values of human and social rights and the principles of non‐formal education, active participation, interculturality and needs centered. Our strategic approach addresses 3 target groups: young people with fewer opportunities, society and our network.
WHY DO WE NEED YOUR DROPS?
By giving your drops to our project, you will contribute to Y-E-N’s future activities and support youth inclusion across Europe.
In 2018, the network will celebrate its 25th anniversary. Our Lilo funds will directly finance the celebration and the activities implemented throughout this special year:
- Video testimonies from former participants, Board members, families etc. who have been involved in the Network and whose life has been impacted by Y-E-N;
- Massive Action Days following the ENTER Recommendations (http://www.coe.int/en/web/enter/the-recommendation) by young people from all around Europe;
- Local events by our Member organisations in 23 different countries;
- And many more (Facebook challenge, Infographics, “Draw My life”)
Our biggest challenge is to produce the videos (material, travels etc.) and that’s for what your drops will help us the most!
Help us make 2018 a memorable year for Youth and Inclusion!
Link to the page: http://youthexpressnetwork.org/
This project has not yet published any news.
Date Amount excl tx
31/12/2019 113.4937 $
Mois en cours 15.7318 $ (estimation)
Reste à payer 7.8659 $
Lilo transfers the money monthly by €100 thresholds.
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Limerick man sues receiver for return of original copy of Amhrán na bhFiann lyrics
Aodhan O'Faolain
The action was brought by Lorcan Bourke against Anne O’Dwyer of Duff Phelps Ireland Ltd who he claims took charge of the property where he had operated Bourke's Bar
A LIMERICK descendant of Peadar Kearney has launched High Court proceedings against a fund appointed receiver seeking the return of items including an original copy of Amhrán na bhFiann signed by the composer.
The action has been bought by Lorcan Bourke against receiver Anne O’Dwyer of Duff Phelps Ireland Ltd who he claims took charge of the property where he had operated Bourke's Bar at Catherine Street in Limerick city until its closure in 2014.
Mr Bourke, a former Garryowen rugby player and a grandson of the late Jack Bourke, three-time Mayor of Limerick, was represented in Court by Richard Kean SC, Gareth Robinson Bl instructed by Georgina Robinson Solicitor is a great grand nephew of Peadar Kearney who wrote the lyrics of the national anthem.
At the High Court on Monday Mr Kean said Mr Bourke is very concerned about the whereabouts of what are very valuable items that had been on display in the bar.
The items include the signed copy of Amhrán na bhFiann, which has been in Mr Kearney's family for many years. The copy was dedicated by Peadar Kearney to Mr Bourke's grandfather Lorcan Bourke, whom the plaintiff is named after.
The copy is an important family heirloom and is extremely valuable, counsel said.
Other items of value that were on display in the pub include two framed pictures with the lyrics of The Fields of Athenry and Dublin in the Rare Auld Times autographed to him by his relative through marriage composer Pete St. John.
His client had been in talks about getting items that had been in the bar returned to him, but has been unable to get them back, counsel said.
Mr Bourke had attended at the property last September and had assumed he would be allowed take what he says are his possessions with him.
Counsel said while inspecting the premises several items were missing and a security official that met with his client made it clear to Mr Bourke that no property was to be removed.
Mr Bourke is concerned that the items may be sold if the receiver is not prevented by the court from doing so, counsel said.
His client's concerns were heightened because he believes that the premises has been sold and will re-open on St Patrick's Day under new management, counsel said.
In his proceedings against the receiver, Mr Bourke seeks injunctions restraining the receiver from selling his chattels in the pub until the case has been resolved.
He also seeks declarations including that, any sale of any of Mr Bourke's items is null and void, and damages.
In a sworn statement to the court Mr Bourke said the pub closed in 2014 after the firm he had leased the premises from got into financial difficulties.
Despite always paying his rent on time and running a successful business he was not able to renew his lease due to the premises owner's difficulties with its bankers.
Following the closure Mr Bourke said he remained in contact with the relevant parties in regards to getting his items, or chattels returned to him.
He said his former landlord's debts were acquired by a fund called Penture Property Finance DAC, who he said appointed Ms O'Dwyer as receiver over the premises in January 2017.
He said following the pub's closure he had to move to Dublin out of economic necessity. Arranging for the removal of all of his items in the pub was extremely difficult.
He said he had left the matter in the hands of professional advisors and had kept in contact with the relevant parties about the items.
He said when he inspected the premises last September several items were missing and he does not know where they are.
As well as the framed song lyrics he said he does not know where other items in the bar that belong to him are, including a grandfather clock, enamel pub signs, bar equipment, sound and light system and furniture.
He says he does not know where many of the items including the signed copy of the national anthem are currently located.
The matter came before Mr Justice David Barniville who, on an ex-parte basis, granted Mr Bourke permission to serve short notice of the proceedings on the receiver.
The Judge agreed with Mr Kean that it would not be appropriate in this matter to grant any orders until both sides have been heard by the court.
The Judge made the matter returnable to Wednesday.
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Making the Case: How to Retain Millennials in Law
May 17, 2016 by Lindsey Pollak in Millennials at Work
This year, we’ve seen news about companies in traditional industries like banking and consulting changing long-standing work practices to address millennials’ expectations about work-life balance and flexibility. (Of course, as one CEO told me, these changes are celebrated by all other generations as well.)
One industry, however, remains as traditional as ever: law. In an industry that still lives and dies by the billable hour, change is especially challenging.
As a recent article in American Lawyer pointed out, some law firms have been slow to adapt to the preferences of a new generation of lawyers. But that will likely need to change: According to the U.S. Bureau of Labor Statistics, millennials comprise nearly a quarter of lawyers.
I’ve shared some changes leaders can make to help millennials thrive in the workplace. Even though most of my advice can be transferred to virtually any industry, law can be a bit of a different animal. I recently had the honor of delivering a conference keynote for the National Association for Law Placement (NALP) about how legal workplaces can better understand and adapt to millennials. Here are five ways suggestions I shared:
Be their coach (and occasionally their cheerleader).
According to The Hartford’s 2015 Millennial Leadership Survey, 60 percent of millennial respondents wanted their employer to provide leadership training. In a busy day filled with meetings and briefs, it can be hard to find time for that training, but it pays off exponentially.
I’ve found that millennials crave clear direction, “common sense” training and actionable feedback. Treating younger associates as apprentices, for instance by inviting them to meetings and court appearances, can pay off in more prepared and engaged associates.
Present multiple options for their career path.
Most law firms have a relatively defined path to the top, but not every associate wants to put in the hours necessary to move to the partner level. If there’s more than one way to be successful at your firm, it’s important to let millennials know. Deloitte calls this option-based system the career “lattice” rather than the “ladder.”
Not interested in creating multiple tracks? That’s fair, but consider that when promising young employees walk out the door, you’re not just losing their experience. You’re losing money. According to a recent article in American Lawyer, firms may invest as much as $250,000 in recruiting and training millennial lawyers.
Let them “job hop” without ever leaving the firm.
According to the 2016 Deloitte Global Millennial Survey, 44 percent of millennials plan to change jobs within the next two years. Since the survey included legal services as one of its industries, that means lawyers, too.
One way to keep millennials: Provide them the variety they crave. Millennials are used to unlimited customization and variety as consumers, so it makes sense that one size doesn’t fit all in their careers.
That’s why law firms should consider offering some elements of customization, such as micro-rotations, self-selected pro bono projects or hackathons to help keep millennial employees challenged and engaged.
Remember that “experience is the new swag.”
Millennials prefer experiences over “stuff.” That’s why law firms should consider the “experience” component of their recruitment, onboarding, training and other efforts.
One great example I recently saw: Some law firms are planning a variety of “Instagram-worthy” events and activities for their summer associates, to help them see the firm as a place that offers more than long hours and a paycheck.
Shift the emphasis from hours spent to work completed or impact achieved.
Let’s circle back to those billable hours. If hours are the best way to show success in the firm, chances are the culture won’t change overnight. But that doesn’t mean you can’t also offer some level of flexibility.
What if it were possible for some associates to work from home on certain projects when appropriate? Or to have a degree of flexibility so they could head to a spin class at 5:30 and then continue to work later in the evening? I know this can be a very hard sell, particularly at big firms, but given the technology available today to work productively from anywhere, it’s worth considering whether some form of flexibility is possible.
Okay, lawyers — what do you think of the above? I’d love to hear from you. What can be done to make law firms a great place for millennials? Please share your stories and ideas in the comments!
Lindsey Pollak is the leading voice on millennials in the workplace, trusted by global companies, universities, the world’s top media outlets — and, most importantly, by millennials themselves. A New York Times bestselling author, Lindsey began her career as a dorm RA in college and has been mentoring millennials — and explaining them to other generations — ever since. Her keynote speeches have audiences so engaged that, in the words of one attendee, “I didn’t check my phone once!” Contact Lindsey to discuss a speaking engagement for your organization.
Filed Under: Millennials at Work Tagged With: generations in the workplace, law firms and millennials, millennials in law, millennials in the workplace
Whitney Boan says
Interesting article. Personally i think the competition for graduate jobs and internships is such that there is little motivation for law firms to change the traditional law firm culture.
These types of changes you suggest normally arise from a companies need to attract employees or in the case of work from home, to cut costs. Until law firms begin to see these market pressures i just don’t see it happening. I hope i’m wrong though!
Lindsey Pollak says
@Whitney – Thanks for the comment!
14 Easy Tips for Creating a More Inclusive Workplace
January 16, 2020 | By Lindsey Pollak
Real Holiday Cheer: 3 Tips to Remix Your Office Holiday Party
December 19, 2019 | By Lindsey Pollak
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Nike says Just Do It.
Maria Sharapova had erred in ignorance taking a banned drug Meldonium in a Latvian medicine brand for her long-standing health condition, and as soon as she realized it, Maria Sharapova went out and just straight-away did what any upstanding individual should have done: Own up. Share all details. Hold nothing back. Express regret. Share the whole picture. And imply that an error of innocence didn’t deserve permanent exile from the game that’s been her life since age 4, and that she deserves to keep playing — after whatever time the sports medicine experts believe it would take for the innocent but unfair advantage of the performance enhancer to disappear from her body. But three of Maria Sharapova’s biggest sponsor brands — Nike, Tag Heuer and Porsche — behaved like pussy-cats (that suffix to keep it decent).
Nike says Just Do It. Sharapova did. She raced off the blocks to own up, some five days after she learnt she’d failed the drug test. On the personal and professional front, as an individual and from a public relations perspective, what Sharapova did was picture-perfect: she received negative news about having failed the drug test at the Australian Open, she made sure she herself was the original source of that news for the media and through it, her fans. She live-streamed the video on her official website.
She spoke virtually extempore, taking maybe three occasional peeps into a small piece of paper, and because she wasn’t reading, she sounded genuine and admission heartfelt. And then, against what most crisis management public relations experts would be wont to advise, she went ahead and took questions from the media which, understandably, had been taken off guard and, of course, aback. That conveyed her openness — that she didn’t have anything to fear because she obviously believed she had not knowingly done anything wrong. In fact, she even joked about the possibility that the media awaiting her might have thought she wanted to announce her retirement. That showed her confidence.
Watch it here:
It was the right thing to do, and she decided to just do it. Like her USD12.5m sponsor Nike preaches.
Nike didn’t practice what it preaches
What do you make of these images from the Nike campaign? Fierce concentration writ large on tense faces, eyes blazing determination, gleaming sweat bespeaking tortuous effort? That these are women and men who believe in their dreams, work bloody hard for them, and will do what they have to to achieve them. The way Nike styles its ads and from it extremely inspirational tag line that will remain relevant forever, one associates all positives with the company and its products. That these athletes and ordinary men and women who train with Nike essentials will only do the right thing. When there is a choice to be made between black and white, they will leap all the way across even the faintest of greys to the white. They will just do it. No compromise. That’s been the perception the brilliant Nike advertising has crafted in my mind. Values-, integrity- and effort-based excellence. Always.
Sharapova did just that. She owned up.
And what did Nike Marketing do? Well, it took the safe damned way out, doing a panicked quick-backstep-double-take, retreating like a pussilanimous brand, belying all the inspirational messaging and designs of its creative over the years.
What did Nike Marketing do? Well, it took the safe damned way out, doing a panicked quick-backstep-double-take, retreating like a pussilanimous brand, belying all the inspirational messaging and designs of its creative over the years
Instead of supporting Sharapova for having come so completely clean in a flash and owning up to taking banned drugs due to her ignorance and innocence, and for having been bold to just go ahead and do the right thing, Nike withdrew from its endorsement contract with Sharapova.
Tag Heuer, which, in spite of having had talks to renew their contract with her, refused to do so. Porsche did likewise, communicating its decision with restraint, saying, “We are saddened by the recent news announced by Maria Sharapova. Until further details are released and we can analyse the situation, we have chosen to postpone planned activities.”
Fair enough. But till the verdict on Sharapova’s situation was out, her sponsors should have stood by her, considering the drug appeared on WADA’s banned list only in Jan this year, and considering that she came clean, owning complete responsibility, and can likely prove she had been taking it over the counter and legally because it was a legitimate medicine and not banned by WADA. If anyone, it’s her support team that should have been keeping a close watch on the medicines she had been taking regularly, and should have been monitoring all WADA updates on new drugs added on the banned list. But that’s water under the bridge now, and that Sharapova didn’t allude to it was great. She made no excuses; took full responsibility.
Serena Williams came out in support of Sharapova. “As Maria said, she’s ready to take full responsibility and I think that showed a lot of courage and a lot of heart,” she told reporters recently.
No courage, no heart
So should Nike have shown similar courage and heart and taken the bold step of believing in Sharpova and standing by her? Should Nike have taken her across the world Tennis hotspots, addressing fans, telling them in person the credible things she’s been sharing through her Facebook page? Should it have convinced itself that Sharapova was on the level about having needed Meldonium? Did it not consider that the drug first appeared on the WADA banned list only on 1 January 2016? And that as soon as she learnt about her innocent transgression, she came clean, owning full responsibility?
Should Nike have considered what the Latvian company that manufactures the drug has said, as reported in The Telegraph, from where I’m reproducing this extract: The Latvian company that manufactures meldonium says the normal course of treatment for the drug is four to six weeks – not the 10 years that Sharapova says she used the substance.
“Depending on the patient’s health condition, treatment course of meldonium preparations may vary from four to six weeks. Treatment course can be repeated twice or thrice a year,” the company said. “Only physicians can follow and evaluate patient’s health condition and state whether the patient should use meldonium for a longer period of time.”
While Grindeks has previously stated that the drug can provide an “improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period,” the company said that it believed the substance would not enhance athletes’ performance in competition and might even do the opposite.
“It would be reasonable to recommend them to use meldonium as a cell protector to avoid heart failure or muscle damage in case of unwanted overload,” the company said. Grindeks said that, in sports activity, the drug slows down how the body breaks down fatty acids to produce energy.
Grindeks did not comment when asked whether someone with the symptoms Sharapova described would be a suitable patient for meldonium. The company said it was designed for patients with chronic heart and circulation conditions, those recovering from illness or injury and people suffering with “reduced working capacity, physical and psycho-emotional overload.” (extract from The Telegraph ends)
Nike has a huge connect with forward thinking and, well, physically moving, people across the age groups, especially millennials. Nike’s ‘physical effort’ ads inspire people to push the envelope. It would have been a great opportunity for Nike to stand up and demonstrate that it does indeed practice what it preaches through every ad and shoe box-and-other-accessories packaging. But alas, it did not Just Do It… it didn’t dump cliched comms thinking. It dumped Sharapova.
There was an opportunity for Nike and the other brands to say, up front, that we do not shortcuts or cheating, but we believe Maria Sharapova when she says he wasn’t aware Meldonium had entered WADA’s banned PEDs list only very recently, and she erred innocently. We respect the need and efforts to cleanse sports of banned PED usage, etc, but we will stand by Maria, who has been the epitome of fine effort and great mettle, until the investigation reaches its conclusion, which we shall respect. And they should have taken her to the tennis capitals across the continents, communicating her message of having erred innocently, but now being on a mission to atone for it by spreading the message against PED usage, and to stress upon the need to be extremely vigilant about relevant knowledge in the space. Supported by Nike. I’d’ve done that.
Porsche too ducked and backed off. Claims to separate Le Mans from Le Boys, according to an ad. Oh, and another Porsche ad I saw somewhere on the profile of a creative director who claims he’d done the creative for them, is a brilliant, edgy thing that says (probably for a Porsche dealership), “Small Penis? Have I Got A Car For You?” Tut Tut. Porsche. Le Boys. Failed the d**k-measuring test.
Like the other brands.
Nike didn’t just do the right thing. Tag Heuer… well… cracked under pressure. And Porsche should have known There is No Substitute for being bold.
Pussycat brands. All three turned their tails between their legs.
Even pussy cats don’t do that. Follow @PavanRChawla
All views personal
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Thought Leaders | Dr Prannoy Roy on worrisome trends in Indian news
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‘Concussion’ doctor: Youth football is child abuse
Bennet Omalu, the pathologist who discovered CTE, says children under 18 shouldn’t play the game
Forensic pathologist Bennet Omalu ignited a conversation this week when saying youth football is like child abuse. (Photo by Pete Marovich/Getty Images)
By Elliott Almond | ealmond@bayareanewsgroup.com, Darren Sabedra | dsabedra@bayareanewsgroup.com and Mike Lefkow | Bay Area News Group
PUBLISHED: August 9, 2017 at 12:18 pm | UPDATED: August 10, 2017 at 3:35 am
The man who brought the concussion issue to the forefront of football has impeached the sport again with perhaps his most explosive statements yet.
Bennet Omalu, who first identified the degenerative brain disease chronic traumatic encephalopathy (CTE) that helped lead to a better understanding of sports-related concussions, said letting youngsters play football is akin to child abuse.
“Someday there will be a district attorney who will prosecute for child abuse, and it will succeed,” said Omalu, San Joaquin County’s chief medical examiner. “It is the definition of child abuse.”
Bennet Omalu doesn’t support ban on football
The NFL’s concussion crisis: A timeline
Super Bowl 50 special report: Is football an endangered species?
Omalu, whose memoir “Truth Doesn’t Have a Side” was released on Tuesday, also said no one under 18 should play football.
The comments this week at the New York Press Club have ignited a conversation about the safety of a sport that is part of American culture. It comes on the heels of a recent study showing 110 of 111 brains of deceased NFL players donated for research had signs of CTE.
Beloved quarterback Jim Plunkett recently revealed to this news organization how much he is suffering from 15 NFL seasons and a collegiate career at Stanford.
It has led to an emotional tug-a-war for fans who still love watching the game but are brokenhearted over the long-term health of their Sunday heroes.
But now Omalu is challenging parents to think about the game for kids.
“If you play football, and if your child plays football, there is a 100 percent risk exposure,” he said. “There is nothing like making football safer. That’s a misnomer.”
The pushback from Bay Area football circles Wednesday was not surprising.
“I think it’s kind of absurd,” former De La Salle coach Bob Ladouceur said. “It’s an outlandish thing to say.”
Rick Martig, whose son Troy was a Bellarmine Prep-San Jose star quarterback two years ago, remains steadfast in his support of football. His perspective encapsulates the thinking of many football families: “There is trauma risk in all the activities that kids do,” he said.
The father, a Bellarmine quarterback in the 1970s who played at Santa Clara University, recalled two of his son’s friends suffering traumatic head injuries while skateboarding.
“Football is more advertised because it’s a very popular sport,” said Martig, adding he trusts the steps that have been taken to ensure safety since his playing days.
Ladouceur, whose career at De La Salle was the subject of the 2014 movie “When the Game Stands Tall,” described football as a calculated risk.
“But the rewards of playing football outweigh the risk of getting seriously hurt,” he added.
Omalu’s life was dramatized in the movie “Concussion” starring Will Smith that highlighted how he took on the NFL establishment to make the game safer. But he now concludes it’s just too violent.
For more Bay Area high school sports coverage follow Bay Area Preps on Flipboard.
“There is nothing the league can do,” said Omalu, scheduled to speak Aug. 23 at the Commonwealth Club of San Francisco. “The league is a corporation. What do corporations do? Make money. If they feel the need to make any changes, they’re making calculated changes that will enhance their bottom line.”
Kimberly Archie of North Hollywood could not have been more grateful to Omalu for taking a hard stand. She has been calling football child abuse since her son’s brain was diagnosed with CTE a year after he died in 2014. Archie is part of a class-action suit in Los Angeles filed against Pop Warner football and the National Operating Committee on Standards Athletic Equipment.
“People will listen to him,” she said. “Moms often get dismissed as emotional. It meant a lot to all the CTE families who buried their kids who just played the game for fun.”
But not even Joshua Nava will turn his back on football although he ended up in a medically induced coma two years ago after tackling an opponent in a high school game in Riverside.
Nava needed emergency brain surgery to stop the bleeding and swelling in the upper left side of the brain. He suffered multiple strokes and spent a year at a hospital learning to walk and talk.
Nava would do it again.
“I don’t think it is child abuse if the kids want to play,” he said. “If they forced them to play then you have to ask. It would be child abuse to not let them play.”
Dave Maronic has been searching for answers since son Toran suffered a brain injury in 2016 during a no-contact, no-pad seven-on-seven scrimmage that left him temporarily in a coma.
Toran, a college prospect in football and lacrosse from Bear River High-Grass Valley, has recovered from the “freak accident.” Toran’s brother is a sophomore playing varsity this upcoming season.
“It is bred in us, we’re a football family,” said Dave Maronic, an executive at a Hayward-based artificial turf company.
He grew up in America’s tradition-rich football country of Harrisburg, Pennsylvania. His grandfather and uncle played professionally.
But the father supports Omalu on one account: suspend tackle football until high school.
“I was a youth football coach for many years,” Maronic said. “That is something I never thought I would say.”
The Maronics launched the Game-Changer Celebrity Golf Classic to help raise funds for research on traumatic brain injuries in high school sports. Dave and many parents involved in youth football advocate teaching proper technique to make it safer instead of eliminating it.
Former Raiders linebacker Tim Johnson has been considering the issue for some time. Seven years ago, he tried to talk NFL officials into returning to leather helmets.
This March, Johnson launched HIP Football League in the Washington D.C./Baltimore area.
The league is 11 vs. 11 two-handed touch. Johnson said players will wear soft-shell helmets without face masks.
“Let’s disarm them from the weapon of a hard-shell helmet,” he said. “The game will never change with the same equipment.”
Johnson hopes to train the next generation of kids to learn alignments and strategies without the need to hit the head.
“America loves sports but we need to love kids just as much,” said Archie, the mother who lost her son.
If you have opinions on Omalu’s thinking, we’d love to hear them. Email us at sports@bayareanewsgroup.com.
Elliott Almond
Elliott Almond is a sports reporter for the Bay Area News Group.
Follow Elliott Almond @elliottalmond
Darren Sabedra
Darren Sabedra is a sports reporter and the high school sports editor, overseeing prep coverage throughout the Bay Area. He's been with the Bay Area News Group since the early 1990s and has covered many sports beats, including Stanford football and basketball, pro baseball and the NFL.
Follow Darren Sabedra @DarrenSabedra
Mike Lefkow
Mike Lefkow is former sports writer for the Bay Area News Group.
Coronavirus update: Human-to-human transmission confirmed
The outbreak has put other countries on alert as millions of Chinese travel for Lunar New Year. Authorities in Thailand and in Japan have already identified at least three cases, all involving recent travel from China.
According to a new study, published last week by University of California scientists in the journal PLOS Medicine, universal coverage plans would actually save money on health care.
A dentist was filmed extracting a tooth while on a hoverboard. He was found guilty on 46 counts
A dentist in Anchorage, Alaska, has been convicted on dozens of charges after he was filmed extracting a patient's tooth as he stood on a hoverboard, according to the Alaska Department of Law.
The warehouse has brought thousands of jobs to Fresno. But workers say the work can be crippling in more ways than one.
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Metso global website News 2007 Metso has agreed to divest its German panelboard press business and to form strategic cooperation with Siempelkamp
Stock Exchange release July 26, 2007 10:45:00 AM CET
Metso has agreed to divest its German panelboard press business and to form strategic cooperation with Siempelkamp
Metso has agreed to divest Metso Panelboard GmbH, a Hannover, Germany-based supplier of continuous press and energy plants for the panelboard industry, to G. Siempelkamp GmbH & Co. KG of Germany. In connection with the divestment, the parties have agreed to pursue cooperation where Metso's front-end, forming and panelhandling technologies will be combined with Siempelkamp's continuous press technology.
The parties have agreed not to disclose the transaction value. The transaction is estimated to be closed by the end of September 2007. Metso Panelboard GmbH employs approximately 65 people, who will transfer to Siempelkamp.
Metso Panelboard is a business line within the Metso Paper business area. Following the divestment, Metso Panelboard will remain a major supplier to the global wood-based panels industry, serving its customers through its own sales and aftermarket organization. Its product and solutions offering covers MDF front end systems, particleboard screening and forming solutions, panelhandling systems, as well as solutions for raw-material cleaning and dry-glue blending. The single- and multi-opening press technology used in special product markets, such as the doorskin production process, will also remain Metso's property.
Metso-Siempelkamp cooperation and the divestment agreement are part of Metso Panelboard's ongoing development and restructuring program, which was started in December 2006. The program focuses on enhancing Metso Panelboard's product portfolio and order-to-delivery capabilites as well as improving the operational efficiency of the business.
Siempelkamp Group is a Germany-based, family-owned international supplier of hydraulic presses, press lines and related services to the woodworking, rubber and metal forming industries. The Group is also a supplier of nuclear technology and foundry products. Its net sales in 2006 were EUR 412 million and it employs over 2,000 people.
is a global engineering and technology corporation with 2006 net sales of approximately EUR 5 billion. Its 26,000 employees in more than 50 countries serve customers in the pulp and paper industry, rock and minerals processing, the energy industry and selected other industries.
Further information for the press, please contact:
Pentti Välimäki, President, Metso Panelboard, tel. +358 40 500 5009
Further information for investors, please contact:
Johanna Sintonen, Vice President, Investor Relations, Metso Corporation, tel. +358 20 484 3253
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Chapter 1488 You're Not Qualified
Rebirth of Martial God By Wo Chi Mian Bao Characters: 6771
A group of people who were the representatives of the East Mainland's top sects left the platform and headed straight to their chosen contestants.
As the delegate of the Vasteras Holy Land started to disperse, a man who was about 25 years of age, suddenly appeared in front of him.
"Steward Gren,"
the young man greeted.
"What's up, Howard?"
Steward Gren, the delegate of the Vasteras Holy Land, asked casually, with a confused expression on his face.
"That Austin Lin, the one who won the first place, someone saw got an intelligent magic treasure in the Black-wind Beast World,"
Howard whispered.
"What? Are you sure about that?" Steward Gren exclaimed as his eyes widened in excitement.
He had been aware of the intelligent magic treasures as they flew out of the Dragon Immortal's mansion. He wanted to get a hold of the magical treasures, for he knew that they were rare and powerful items.
"Yes. I chased him in the Black-wind Beast World, but he got away,"
Howard confirmed with a nod.
"A weak young man like him isn't qualified to have an intelligent magic treasure from the Dragon Immortal's mansion.
Fine, I'll get him to hand the intelligent magic treasure to us," Steward Gren said.
He instantly flew towards the square, followed by Howard.
The square was filled with representatives of the East Mainland's top sects as they gathered on the contestants they favored and invited them to join their sect.
Participants who ranked from the sixteenth to the thirties had the chance to be a part of six major sects of the Solamnia Kingdom.
The delegates from the top sects of the East Mainland only recruited those who ranked into the top 15.
"You're Belle Xiao, right? I'm a representative of the Jade Sect. You're such a lucky girl to have the legendary Crystal Moonlight Body. I believe that if you learn our secret martial art skills, you will make great achievements in the field of martial arts.
Once you decide to join us, we'll provide you the best cultiva
The Mighty Soldier King is back!
With the original intention to protect his beautiful boss, he accidentally gets involved in dangerous adventures and trouble.
Will our Mighty Soldier King be defeated? Or will he sweep away all obstacles?
he was, he didn't show it on his face.
"I watched you fight.
I have to admit you did a good job in the test.
But do you know what your fatal weakness is?"
the man in yellow said indifferently.
"I know I'm far from being an excellent cultivator. I would appreciate it a lot if you can enlighten me," Austin responded.
He suddenly had a feeling that this man wasn't here to invite him to join the Vasteras Holy Land.
"Looks like this guy isn't happy with you. I don't think he's here to recruit you,"
the Flame Emperor said.
"Fine.
Your merits include a profound sword skill, your demonic avatar and a mysterious spiritual sense martial skill.
But these are all external forces.
You won the tournament because you resorted to these external forces. It suggests that you're not a hardworking cultivator. You just want to improve your strength by cutting corners. If you don't change your ways, you will not make any great achievements in martial arts.
There is something I hope you will keep in mind: cultivation base matters the most to a cultivator;
the only way to enhance your strength is to work on your cultivation base.
Even though you won the first place in this tournament, you're not qualified to be a member of a holy land,"
the man in yellow said.
'I knew it.'
Austin's eyes widened.
The Legend of Innate Mage
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» Volunteer Army
Armored Locomotive
Last Updated on Sun, 17 Nov 2019 | Volunteer Army
White armored train, Rostov-on-Don, 1919. Sources indicate this train may be either the General Drozdovsky, or a Don Cossack train. The lettering, apparently in black along the side of the first wagon, is indecipherable. (Kolomiets)
British identification colors of white and red. The Whites painted the tank's name in white on the front sloping plate below the front cab and retained the tank's number in white on the side and to the rear of the sponson (see insets).
For Holy Russia penetrated deep into the Red defenses at Kakhovka in October 1920 before being struck in the left side by artillery. Red captors cannibalized parts from other Mark Vs taken in action in order to repair the tank and subsequently renamed it the Muscovite Proletarian.
E1: CZECH ARMORED MOTOR WAGON ZAAMUREC, SIBERIA 1919-20
The Czech Legion captured Red armored train No. 4, Polupanov, in Simbirsk on 22 July 1918. This train consisted of the Zaamurec motor wagon, two artillery wagons, an armored locomotive and a tender. The Czechs renamed this armored train Orlik or "Young Eagle." Zaamurec had been designed in 1916 on a Fax-Arbel flatbed, with walls of 16mm (0.63in.) armor (12mm/0.47in. on sloped sections) and two Italian 60-hp petrol engines. Each turret could rotate 360 degrees and the guns could fire 10 degrees downward and 60 degrees upward. Fire control turrets were added in
1917. Zaamurec carried eight machine guns, eight periscopes, an intercom system, signaling equipment, two searchlights and two artillery range finders. The original 57mm Nordenfeld guns were changed to 76.2mm weapons in
1918. The name Orlik appeared in white, machine-metaled letters that were bolted onto the right side of the front turret; thus, in this depiction, the letters would appear on the opposite side. The letters vuz cis. 1. mean "wagon number 1." Zaamurec could operate as part of the Orlik configuration, or independently.
E2: CZECH ARMORED TRAIN ORLIK, CENTRAL SIBERIA, 1919-20
This plate depicts the usual components of Orlik, exclusive of the Zaamurec motor wagon. The first Czech national flag of white and red appears in the inset. Orlik had a "ChN" type armored locomotive with 12mm (0.47in.) steel plating, that burned either coal or wood. The Orlik echelon or configuration included two double-axle artillery wagons with similar profiles, each mounting 12 machine guns. The first, with a conical gun turret, carried a 76.2mm Model 1902 piece, while the second, with a cylindrical turret, sported a mountain gun, 76.2mm Model 1904. The turrets could traverse 270 degrees. The crew of 100 included four officers. The train roamed the length of the Trans-Siberian, clearing away Red and Green partisans until the Czech evacuation from Vladivostok in May 1920. Thereafter, Orlik served the remnants of the White Army operating in the Russian Far East. After Vladivostok fell to the Reds in 1922. the Whites moved the train to Manchuria where it served a local Chinese warlord for six years before vanishing from history.
F1: VOLUNTEER ARMY ARMORED TRAIN FORWARD FOR FATHERLAND, SUMMER 1918
Established on 14 July 1918 at Tikhoretskaia, after being captured from the Reds, the train's composition included an armored "Ov" type locomotive and armored tender, a half-armored wagon with a 75mm piece, a machine-gun wagon with eight machine guns (not shown here) and an armored wagon with a 3-in. gun. The name appeared in white on the side of the engine. The double-headed eagle emblem of the Romanovs can be seen in white on the side of the 3-in. gun wagon. This train participated in the second Kuban campaign, the clearing of the northern Caucasus and subsequently served in the Caucasian Army, AFSR.
F2: VOLUNTEER ARMY, ARMORED TRAIN OFFICER, FEBRUARY 1919
The Whites captured Officer in August 1918. The crew numbered 48 officers and 67 enlisted men. Abandoned at Novorossisk in March 1920, the train configuration and crew re-emerged in the Crimea as the Glory of Kuban in April.
Officer comprised two identical double-axle armored gun wagons that housed 76.2mm Model 1902 field pieces with a 360-degree traverse, an armored "Ch" type locomotive, and a tender that contained the commander's compartment and two machine guns. The casement of the armored gun wagons sported 12 Maxim machine guns, five per side and
Don Cossack train, south Russia, 1919. The white letters along the side read "Train of Don Propaganda Section... " before becoming indecipherable. The emblem left of center is on all train wagons. The field of the emblem alternates black and orange, colors of the Order of St. George, given for heroism. Superimposed on the field at the top is a silver sword piercing a silver crown of thorns, an heroic symbol of sacrifice adopted by the Volunteer Army and Don Cossacks who had participated in the "Ice March" in the Kuban during 1918. The chevron from bottom to top is red, blue and white. (Deryabin)
an additional pair capable of firing forward from the front of each wagon.
The enlarged portion of this plate reveals machine-gun ports, the double-headed Imperial eagle in white, and the tricolor roundel. The Volunteer Army painted Officer in white lettering on both sides of each gun wagon as well as at the front of each turret.
G1: VOLUNTEER ARMY ARMORED TRAIN TO MOSCOW, WINTER 1919-SPRING 1920
Established 13 September 1919 at the Sudostal Works, Novorossisk, the heavy armored train To Moscow defended the Rostov-Novorossisk sector until being captured by the
Reds in March 1920. The echelon consisted of two almost identical gun wagons (each with two machine guns in sponsons on the side), at least one machine-gun wagon and an engine and tender. The gun wagons had the black lettering (with red shading behind the black) To Moscow superimposed on the side and front over Volunteer Army chevrons. The black double-headed eagle symbolizes Russia's claim to be the Third Rome after the fall of the Byzantine Empire and is seen here without the crown, orb and scepter of the Romanov Dynasty. The flag bears the Russian tricolor in the upper corner and also the symbol of the armored train service, that of crossed cannon barrels and a winged wheel on rails. Black numbers 9 49922 and 9 48878 appeared to the front of the gun wagons. According to Russian sources, the guns were 107mm or 122mm weapons; however, the gun on this wagon appears to be a remounted British 60-pdr. The train itself appears in heavily weathered khaki.
G2: WHITE SIBERIAN ARMORED TRAIN VITYAZ, FALL 1920
Established in spring 1920, Vityaz or "Knight" had a complement of 100 officers and 35 enlisted men, commanded by Colonel F.F. Meibom. All were select volunteers from the late General V.O. Kappel's Volga Brigade. Vityaz fought in eastern Siberia and in one encounter destroyed the Red armored train Comrade Blyukher.
This train consisted of an armored locomotive and tender, two armored wagons, two semi-armored wagon platforms with guns and two wagon platforms carrying engineering material. The six guns included one naval Canet. a 4.5-in. howitzer, one 47mm Hotchkiss on the tower next to the commander and three 3-in. Japanese field pieces. Ten Maxim and eight Colt machine guns bristled along the casements of the armored wagons. The armored train's name in white was superimposed above the white lettering "For Rus. Sacred, United and Indivisible." Above the commander's position flew the Russian national flag.
Kuban Cossack armored train No. 4, constructed by the Kuban Railway Sotnia. The letters, crossed axe, and anchor are white. Note the well-armored locomotive. (Kolomiets)
Nationalists Versus Communists 192745
White Armored Trains - Volunteer Army
The Allies in Siberia - Bullock Collection
Specifications - Volunteer Army
Gunner 1st US Artillery - Museum Philadelphia
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Kansas City and St. Louis, Missouri, each ranked among the 10 best “untapped” cities for startups in 2020, according to a new report. St. Louis ranked sixth on the list, while Kansas City tied for tenth.
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Microbiology — Recommend this title to your library
Microbiology - Volume 145, Issue 10, 1999
Volume 145, Issue 10, 1999
Cloning and assembly strategies in microbial genome projects
Lionel Frangeul, Karen E. Nelson, Carmen Buchrieser, Antoine Danchin, Philippe Glaser and Frank Kunst
https://doi.org/10.1099/00221287-145-10-2625
Microbiology Comment
Nanobacteria and associated ‘elementary bodies’ in human disease and cancer
Milton Wainwright
Antigens And Immunity
Antibodies to a synthetic 1–9-N-terminal amino acid fragment of mature pediocin PA-1: sensitivity and specificity for pediocin PA-1 and cross-reactivity against Class IIa bacteriocins
José M. Martı́nez, Marı́a I. Martı́nez, Carmen Herranz, Ana Suárez, Marı́a F. Fernández, Luis M. Cintas, Juan M. Rodrı́guez and Pablo E. Hernández
Polyclonal antibodies specific for pediocin PA-1 (PedA1) were generated by immunization of rabbits with a chemically synthesized 1–9-N-terminal amino acid fragment of this bacteriocin (PH1) conjugated to the carrier protein keyhole limpet haemocyanin (KLH). The PH1 fragment holds a highly conserved amino acid sequence with closely related Class IIa bacteriocins. The sensitivity and specificity of the PH1–KLH-generated rabbit polyclonal antibodies were evaluated by the development of various ELISAs, such as a non-competitive indirect ELISA (NCI-ELISA), a competitive indirect ELISA (CI-ELISA), a competitive direct ELISA (CD-ELISA) and a sandwich ELISA (S-ELISA), and by protein slot-blotting and Western blotting. NCI- and CI-ELISA were valuable for detecting the existence of PedA1-specific antibodies in the sera of immunized rabbits. The limit of detection of PedA1 in MRS medium was found to be 0·5 μg ml−1 in NCI-ELISA, while CI-ELISA on plates coated with purified PedA1 increased the affinity of the PH1–KLH-generated antibodies for PedA1; the limit of detection of PedA1 was less than 0·01 μg ml−1 and 50% binding inhibition was achieved with 0·1 μg PedA1 ml−1. Similarly, the limits of detection of PedA1 in MRS medium were found to be 5 μg ml−1 by protein slot-blotting and 0·01 μg ml−1 by Western blotting. Most importantly, PH1–KLH-generated polyclonal antibodies detected the presence of PedA1 in the supernatants of the producing strains of Pediococcus acidilactici 347, Z102, A172, X13 and P20, with no reactivity or negligible immunoreactivity with the supernatants of other lactic acid bacteria producing or not producing closely related or different bacteriocins. The approaches taken for the selection of the bacteriocin peptide fragment, the generation of antibodies and the development of immunoassays could prove useful for the generation and evaluation of antibodies of adequate specificity for other bacteriocins of interest in the food industry.
A low-M r lipase activation factor cooperating with lipase modulator protein LimL in Pseudomonas sp. strain 109
Junko Tanaka, Fumio Ihara, Takuya Nihira and Yasuhiro Yamada
Pseudomonas sp. strain 109 produces a unique lipase (LipL) which efficiently catalyses intramolecular transesterification of ω-hydroxyesters to form macrocyclic lactones. In vivo production of enzymically active LipL requires lipase modulator protein (LimL), which functions as a molecular chaperone for the correct folding of LipL. However, previous work has shown that LipL forms a tight complex with LimL in vitro and the resulting LipL–LimL complex is only partially active, suggesting an additional mechanism that facilitates the dissociation of the complex to form enzymically active LipL. In the present work, a low-M r compound (lipase activation factor, LAF) was found in Pseudomonas sp. strain 109 that when added to the LipL–LimL complex resulted in the activation of LipL. Ca2+ ions also enhanced lipase activity, but the instantaneous activation by Ca2+ was different from the gradual and time-dependent activation by LAF, indicating the novel nature of this compound. LAF passed through an ultrafiltration membrane with an M r cut-off of 3000 and showed an apparent M r of 330±30 on Superdex Peptide gel-filtration chromatography. Treatment of the LipL–LimL complex with LAF liberated free active LipL, indicating that LAF was necessary to dissociate the LipL–LimL complex.
Bioenergetics And Transport
Staphylococcal phosphoenolpyruvate-dependent phosphotransferase system – two highly similar glucose permeases in Staphylococcus carnosus with different glucoside specificity: protein engineering in vivo?
Ingo Christiansen and Wolfgang Hengstenberg
Previous sequence analysis of the glucose-specific PTS gene locus from Staphylococcus carnosus revealed the unexpected finding of two adjacent, highly similar ORFs, glcA and glcB,each encoding a glucose-specific membrane permease EIICBAGlc. glcA and glcB show 73% identity at the nucleotide level and glcB is located 131 bp downstream from glcA. Each of the genes is flanked by putative regulatory elements such as a termination stem–loop, promoter and ribosome-binding site, suggesting independent regulation. The finding of putative cis-active operator sequences, CRE (catabolite-responsive elements) suggests additional regulation by carbon catabolite repression. As described previously by the authors, both genes can be expressed in Escherichia coli under control of their own promoters. Two putative promoters are located upstream of glcA, and both were found to initiate transcription in E. coli. Although the two permeases EIICBAGlc1 and EIICBAGlc2 show 69% identity at the protein level, and despite the common primary substrate glucose, they have different specificities towards glucosides as substrate. EIICBAGlc1 phosphorylates glucose in a PEP-dependent reaction with a K m of 12 μM; the reaction can be inhibited by 2-deoxyglucose and methyl β-D-glucoside. EIICBAGlc2 phosphorylates glucose with a K m of 19 μM and this reaction is inhibited by methyl α-D-glucoside, methyl β-D-glucoside, p-nitrophenyl α-D-glucoside, o-nitrophenyl β-D-glucoside and salicin, but unlike other glucose permeases, including EIICBAGlc1, not by 2-deoxyglucose. Natural mono- or disaccharides, such as mannose or N-acetylglucosamine, that are transported by other glucose transporters are not phosphorylated by either EIICBAGlc1 nor EIICBAGlc2, indicating a high specificity for glucose. Together, these findings support the suggestion of evolutionary development of different members of a protein family, by gene duplication and subsequent differentiation. C-terminal fusion of a histidine hexapeptide to both gene products did not affect the activity of the enzymes and allowed their purification by Ni2+-NTA affinity chromatography after expression in a ptsG (EIICBGlc) deletion mutant of E. coli. Upstream of glcA, the 3’ end of a further ORF encoding 138 amino acid residues of a putative antiterminator of the BglG family was found, as well as a putative target DNA sequence (RAT), which indicates a further regulation by glucose specific antitermination.
Substrate specificity of the periplasmic dipeptide-binding protein from Escherichia coli: experimental basis for the design of peptide prodrugs
Mark W. Smith, David R. Tyreman, Gillian M. Payne, Neil J. Marshall and John W. Payne
Pure dipeptide-binding protein (DppA) from Escherichia coli was studied in a filter binding assay to determine its binding specificity. A substrate:DppA stoichiometry of 1:1 was found with both [14C]AlaAla and Ala[14C]Phe. Surprisingly, substrate binding did not vary over the pH range pH 3–9·5. Different dipeptides yielded liganded protein with various pI values, implying that DppA can undergo subtly different conformational changes to accommodate different substrates. Using [125I]Tyr-peptides as substrates in competition assays, the relative binding affinities for a range of dipeptides were found to parallel their overall transport rates into E. coli through the dipeptide permease (Dpp), showing that DppA alone controls the specificity of Dpp. With a series of substituted glycyl peptides, binding affinity was progressively enhanced by alkylation (with methyl to butyl) of the N-terminal α-amino group. Thus, results from this approach provide an essential experimental basis, which complements the information from the crystal structure of DppA, for the design of peptidomimetic antibacterials targeted for transport through Dpp.
Development And Structure
A re-examination of twitching motility in Pseudomonas aeruginosa
Annalese B. T. Semmler, Cynthia B. Whitchurch and John S. Mattick
Twitching motility is a form of solid surface translocation which occurs in a wide range of bacteria and which is dependent on the presence of functional type IV fimbriae or pili. A detailed examination of twitching motility in Pseudomonas aeruginosa under optimal conditions in vitro was carried out. Under these conditions (at the smooth surface formed between semi-solid growth media and plastic or glass surfaces) twitching motility is extremely rapid, leading to an overall radial rate of colony expansion of 0·6 mm h−1 or greater. The zones of colony expansion due to twitching motility are very thin and are best visualized by staining. These zones exhibit concentric rings in which there is a high density of microcolonies, which may reflect periods of expansion and consolidation/cell division. Video microscopic analysis showed that twitching motility involves the initial formation of large projections or rafts of aggregated cells which move away from the colony edge. Behind the rafts, individual cells move rapidly up and down trails which thin and branch out, ultimately forming a fine lattice-like network of cells. The bacteria in the lattice network then appear to settle and divide to fill out the colonized space. Our observations redefine twitching motility as a rapid, highly organized mechanism of bacterial translocation by which P. aeruginosa can disperse itself over large areas to colonize new territories. It is also now clear, both morphologically and genetically, that twitching motility and social gliding motility, such as occurs in Myxococcus xanthus, are essentially the same process.
Environmental Microbiology
The distribution of enteric bacteria from Australian mammals: host and geographical effects
David M. Gordon and Frances FitzGibbon
Bacteria of the family Enterobacteriaceae were isolated from 642 mammalian hosts, representing 16 families and 79 species, collected from throughout Australia. Escherichia coli was the most common of the 24 enteric species recovered and represented almost half of the isolates. Association analysis revealed that most other species of bacteria were less likely to be recovered from hosts in which E. coli was present. The composition of the enteric community of a host was found to be determined by both the taxonomic family to which the host belonged and the geographical area from which the host was collected. Hosts collected from the northern areas of Queensland and the Northern Territory had more diverse enteric communities than hosts collected from New South Wales or Western Australia. Hosts of the families Petauridae and Vespertilionidae had more diverse enteric communities than did members of the Macropodidae or Phalangeridae. The probability of occurrence of Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Hafnia alvei, Klebsiella oxytoca and K. pneumoniae in a host was found to vary with respect to host family and/or host locality. The non-random distribution of these species demonstrates the presence of extensive population structure and may suggest the existence of adaptations specific to both the primary and secondary habitats of these enteric bacteria.
The genetic structure of enteric bacteria from Australian mammals
David M. Gordon and Joannah Lee
A total of 246 isolates representing five species of the family Enterobacteriaceae, taken from a variety of Australian mammal species, were characterized using multi-locus enzyme electrophoresis. Genome diversity estimates varied significantly among species, with the Klebsiella pneumoniae sample exhibiting the lowest diversity and the Citrobacter freundii sample the highest. Multi-locus linkage disequilibrium estimates revealed that alleles were non-randomly associated in all five species samples, but the magnitude of the estimates differed significantly among species. Escherichia coli had the lowest linkage disequilibrium estimate and Klebisella oxytoca the largest. Molecular analyis of variance was used to determine the extent to which population structure explained the observed genetic variation in a species. Two population levels were defined: the taxonomic family of the host from which the isolate was collected and the geographical locality where the host was collected. The amount of explained variation varied from 0% for K. oxytoca to 22% for K. pneumoniae. Host locality explained a significant amount of the genetic variation in the C. freundii (12%), E. coli (5%), Hafnia alvei (17%) and K. pneumoniae (22%) samples. Host family explained a significant fraction of the variation in E. coli (6%) H. alvei (7%) and K. pneumoniae (20%). Estimates of effective population size for all five species, based on the probability that two randomly chosen isolates will be identical, failed to reveal any relationship between the effective population size and the genetic diversity of a species.
The relationship between critical pressure and width of gas vesicles in isolates of Planktothrix rubescens from Lake Zürich
D. I. Bright and A. E. Walsby
The mean critical collapse pressure (p c) of gas vesicles in 81 strains of the cyanobacterium Planktothrix rubescens from Lake Zürich, Switzerland, was bimodally distributed between a minimum of 0·86 MPa and a maximum of 1·17 MPa. Measurements were made of the cylinder diameter (d) of gas vesicles isolated from seven of the strains. The mean diameter, which varied from 48 to 61 nm, was inversely related to p c, in keeping with the theory of strength of thin-walled rigid cylinders. These measurements extended the range of p c–width relationship of gas vesicles, which can be described by the expression p c=461(d/nm)−1·53 MPa. p c was correlated with gas vesicle genotype (see the accompanying paper by S. J. Beard, B. A. Handley, P. K. Hayes & A. E. Walsby, Microbiology 145, 2757–2768): of the 81 strains investigated, all those with the gas vesicle genotype GV2 produced gas vesicles with a mean p c of less than 1·0 MPa, whereas those of GV3 had a mean p c of greater than 1·0 MPa. It is suggested that gas vesicles of the GV3 strains, which are narrower and stronger than any previously recorded in freshwater cyanobacteria, have evolved to withstand the high hydrostatic pressures during deep winter mixing in Lake Zürich.
The effect of motility and cell-surface polymers on bacterial attachment
Hisao Morisaki, Shinichi Nagai, Hiroyuki Ohshima, Eiko Ikemoto and Kazuhiro Kogure
Recently it was shown that motility of Vibrio alginolyticus facilitated cell attachment to glass surfaces. In the present study the same relationship between motility and cell attachment was confirmed for Alcaligenes and Alteromonas spp. These findings clearly answer a long-standing question: does motility facilitate attachment? However, they are contradictory to a general view on cell attachment that the energy barrier due to electrostatic repulsion between negatively charged bacterial cells and a glass surface is much greater than both the thermal kinetic energy of the bacterial cell and the bacterial swimming energy. It is shown that the energy barrier becomes far less than that usually estimated when bacterial cells are rich in polymers at their surfaces. This finding reasonably explains the dependence of bacterial attachment rate on cell motility and demands reconsideration of the mechanism of bacterial attachment.
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441
Hiroyuki Arai, Takako Yamamoto, Tohru Ohishi, Takeshi Shimizu, Tadashi Nakata and Toshiaki Kudo
Comamonas testosteroni TA441 degrades 3-(3-hydroxyphenyl)propionate (3HPP) via the meta pathway. A gene cluster required for degradation of 3HPP was cloned from strain TA441 and sequenced. The genes encoding six catabolic enzymes, a flavin-type hydroxylase (mhpA), extradiol dioxygenase (mhpB), 2-keto-4-pentenoate hydratase (mhpD), acetaldehyde dehydrogenase (acylating) (mhpF), 4-hydroxy-2-ketovalerate aldolase (mhpE) and the meta cleavage compound hydrolase (mhpC), were found in this cluster, encoded in this order. mhpD and mhpF were separated by two genes, orf4 and orf5, which were not necessary for growth on 3HPP. The gene mhpR, encoding a putative transcriptional activator of the IclR family, was located adjacent to mhpA in the opposite orientation. Disruption of the mhpB or mhpR genes affected growth on 3HPP or trans-3-hydroxycinnamate. The mhpB and mhpC gene products showed high specificity for 3-(2,3-dihydroxyphenyl)propionate (DHPP) and the meta cleavage compound produced from DHPP, respectively.
Occurrence and expression of glutathione-S-transferase-encoding bphK genes in Burkholderia sp. strain LB400 and other biphenyl-utilizing bacteria
Frank Bartels, Silke Backhaus, Edward R. B. Moore, Kenneth N. Timmis and Bernd Hofer
The gene bphK of Burkholderia sp. strain LB400 has previously been shown to be located within the bph locus, which specifies the degradation of biphenyl (BP) and chlorobiphenyls, and to encode a glutathione S-transferase (GST) which accepts 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. The specific physiological role of this gene is not known. It is now shown that the gene is expressed in the parental organism and that GST activity is induced more than 20-fold by growth of the strain on BP relative to succinate when these compounds serve as sole carbon source. Approximately the same induction factor was observed for 2,3-dihydroxybiphenyl 1,2-dioxygenase activity, which is encoded by the 5′-adjacent bphC gene. This suggests that the expression of bphK is coregulated with the expression of genes responsible for the catabolism of BP. A bphK probe detected only a single copy of the gene in strain LB400. A spontaneous BP− mutant of the organism neither gave a signal with the bphK probe nor showed CDNB-accepting GST activity, suggesting that this activity is solely encoded by bphK. Complementation of the mutant with a bph gene cluster devoid of bphK restored the ability to grow on BP, indicating that bphK is not essential for utilization of this carbon source. BphK activity proved to be almost unaffected by up to 100-fold differences in proton concentration or ionic strength. The enzyme showed a narrow range with respect to a variety of widely used electrophilic GST substrates, accepting only CDNB. A number of established laboratory strains as well as novel isolates able to grow on BP as sole carbon and energy source were examined for BphK activity and the presence of a bphK analogue. CDNB assays, probe hybridizations and PCR showed that several, but not all, BP degraders possess this type of GST activity and/or a closely related gene. In all bacteria showing BphK activity, this was induced by growth on BP as sole carbon source, although activity levels differed by up to 10-fold after growth on BP and by up to 60-fold after growth on succinate. This resulted in a variation of induction factors between 2 and 30. In the majority of bphK + bacteria examined, the gene appeared to be part of LB400-like bph gene clusters. DNA sequencing revealed almost complete identity of bphK genes from five different bph gene clusters. These results suggest that bphK genes, although not essential, fulfil a strain-specific function related to the utilization of BPs by their host organisms. The usefulness of BphK as a reporter enzyme for monitoring the expression of catabolic pathways is discussed.
Expression of leading region genes on IncI1 plasmid ColIb-P9: genetic evidence for single-stranded DNA transcription
Steven Bates, Richard A. Roscoe, Nicola J. Althorpe, William J. Brammar and Brian M. Wilkins
The leading region of a plasmid is the first sector to enter the recipient cell in bacterial conjugation. This sector of IncI1 plasmid ColIb-P9 includes genes that are transcribed in a transient pulse early in the conjugatively infected cell to promote establishment of the immigrant plasmid. Evidence is presented that the burst of gene expression is regulated by a process which is independent of a repressor but dependent on the orientation of the genes on the unique plasmid strand transferred in conjugation. The nucleotide sequence of 11·7 kb of the leading region was determined and found to contain 10 ORFs; all are orientated such that the template strand for transcription corresponds to the transferred strand. The leading region contains three dispersed repeats of a sequence homologous to a novel promoter in ssDNA described by H. Masai & K. Arai (1997 R20 , Cell 89, 897–907). It is proposed that the repeats are promoters that form in the transferring strand of ColIb to support transient transcription of genes transferred early in conjugation.
The diversity of gas vesicle genes in Planktothrix rubescens from Lake Zürich
S. J. Beard, B. A. Handley, P. K. Hayes and A. E. Walsby
Part of the gas vesicle gene cluster was amplified by PCR from three strains of Planktothrix rubescens isolated from Lake Zürich, Switzerland. Each contains multiple alternating copies of gvpA and gvpC. All of the gvpA sequences in the different strains are identical. There are two types of gvpC: gvpC 20, of length 516 bp, encodes a 20 kDa protein of 172 amino acid residues (whose N-terminal amino acid sequence is homologous with the sequence of GvpC in Planktothrix [Oscillatoria] agardhii); gvpC 16, of length 417 bp, encodes a 16 kDa protein of 139 amino acid residues that differs in lacking an internal 33-residue section. An untranslated 72 bp fragment from the 3′ end of gvpC, designated ΩC, is also present in some strains. The two types of gvpC and presence of ΩC could be distinguished by the different lengths of PCR amplification products obtained using pairs of oligonucleotide primers homologous to internal sequences in gvpC and gvpA. Three genotype classes were found: GV1, containing only gvpC 20; GV2, containing gvpC 20 and ΩC; and GV3, containing gvpC 16, gvpC 20 and ΩC. Subclasses of GV2 and GV3 contained either one or two copies of ΩC. The accompanying paper by D. I. Bright & A. E. Walsby (Microbiology 145, 2769–2775) shows that strains of the GV3 genotype produce gas vesicles with a higher critical pressure than those of GV1 and GV2. A PCR survey of 185 clonal cultures of P. rubescens isolated from Lake Zürich revealed that 3 isolates were of genotype GV1, 73 were of GV2 and 109 were of GV3. The PCR technique was used to distinguish the gas vesicle genotype, and thence the associated critical-pressure phenotype, of single filaments selected from lakewater samples. Sequence analysis of the 16S rDNA and of regions within the operons encoding phycoerythrin, phycocyanin and Rubisco confirmed that these strains of Planktothrix form a tight phylogenetic group.
Transcriptional regulation in response to oxygen and nitrate of the operons encoding the [NiFe] hydrogenases 1 and 2 of Escherichia coli
Derek J. Richard, Gary Sawers, Frank Sargent, Laura McWalter and David H. Boxer
Synthesis of the [NiFe] hydrogenases 1 and 2 of Escherichia coli is induced in response to anaerobiosis and is repressed when nitrate is present in the growth medium. The hydrogenase 1 and hydrogenase 2 enzymes are encoded by the polycistronic hyaABCDEF and hybOABCDEFG operons, respectively. Primer extension analysis was used to determine the initiation site of transcription of both operons. This permitted the construction of single-copy lacZ operon fusions, which were used to examine the transcriptional regulation of the two operons. Expression of both was induced by anaerobiosis and repressed by nitrate, which is in complete accord with earlier biochemical studies. Anaerobic induction of the hyb operon was only partially dependent on the FNR protein and, surprisingly, was enhanced by an arcA mutation. This latter result indicated that ArcA suppresses anaerobic hyb expression and that a further factor, which remains to be identified, is involved in controlling anaerobic induction of operon expression. Nitrate repression of hyb expression was mediated by the NarL/NarX and NarP/NarQ two-component regulatory systems. Remarkably, a narP mutant lacked anaerobic induction of hyb expression, even in the absence of added nitrate. Anaerobic induction of hya expression was dependent on the ArcA and AppY regulators, which confirms earlier observations by other authors. Nitrate repression of the hya operon was mediated by both NarL and NarP. Taken together, these data indicate that although the hya and hyb operons share common regulators, there are important differences in the control of expression of the individual operons.
The dnaA gene region of Mycobacterium avium and the autonomous replication activities of its 5′ and 3′ flanking regions
Murty V. V. S. Madiraju, Ming-Hui Qin, Kohji Yamamoto, Mark A. L. Atkinson and Malini Rajagopalan
A 3·9 kb DNA fragment containing the dnaA gene region of Mycobacterium avium was cloned and its nucleotide sequence was determined. Nucleotide sequence analyses indicated that this region encodes three genes in the order rpmH (ribosomal protein L34), dnaA (the putative initiator protein) and dnaN (the β subunit of DNA polymerase III). The intergenic regions between the rpmH–dnaA and dnaA–dnaN genes were found to contain several putative DnaA boxes, 9 nt long DnaA protein recognition sequences. A DNA fragment containing the 3′ but not the 5′ flanking region of the M. avium dnaA gene when cloned in Escherichia coli plasmids, which are otherwise non-replicative in mycobacteria, exhibited autonomous replication activity in M. avium but not in Mycobacterium bovis BCG and Mycobacterium smegmatis. The 5′ flanking region of dnaA, on the other hand, exhibited autonomous replication activity in M. bovis BCG but not in M. avium and M. smegmatis. The implications of these results for the understanding of the M. avium oriC replication initiation process are discussed.
Use of fluorescence induction and sucrose counterselection to identify Mycobacterium tuberculosis genes expressed within host cells
James A. Triccas, François-Xavier Berthet, Vladimir Pelicic and Brigitte Gicquel
The identification of Mycobacterium tuberculosis genes expressed within host cells would contribute greatly to the development of new strategies to combat tuberculosis. By combining the natural fluorescence of the Aequoria victoria green fluorescent protein (GFP) with the counterselectable property of the Bacillus subtilis SacB protein, M. tuberculosis promoters displaying enhanced in vivo activity have been isolated. Macrophages were infected with recombinant Mycobacterium bovis bacille Calmette–Guérin containing a library of M. tuberculosis promoters controlling gfp and sacB expression, and fluorescent bacteria recovered by fluorescence-activated cell sorting. The expression of sacB was used to eliminate clones with strong promoter activity outside the macrophage, resulting in the isolation of seven clones containing M. tuberculosis promoters with greater activity intracellularly. The gene products identified displayed similarity to proteins from other organisms whose functions include nutrient utilization, protection from oxidative stress and defence against xenobiotics. These proposed functions are consistent with conditions encountered within the host cell and thus suggest that the augmented activity of the isolated promoters/genes may represent strategies employed by M. tuberculosis to enhance intracellular survival and promote infection.
Regulation of polyphosphate kinase gene expression in Acinetobacter baumannii 252
Julie-Ann Gavigan, Leonard M. Marshall and Alan D. W. Dobson
A strain of Acinetobacter baumannii cultured in butyric acid media was found to take up phosphate following a period of phosphate release. PCR was used to clone the polyphosphate kinase (ppk) gene from the strain. The promoter for the ppk gene was functional in the heterologous Escherichia coli host. Using RT-PCR, transcription of the ppk gene was found to be regulated by phosphate concentration.
Two fatty acid Δ9-desaturase genes, ole1 and ole2, from Mortierella alpina complement the yeast ole1 mutation
Prasert Wongwathanarat, Louise V. Michaelson, Andrew T. Carter, Colin M. Lazarus, Gareth Griffiths, A. Keith Stobart, David B. Archer and Donald A. MacKenzie
Genes encoding two distinct fatty acid Δ9-desaturases were isolated from strains of the oleaginous fungus Mortierella alpina. Two genomic sequences, Δ9-1 and Δ9-2, each containing a single intron, were cloned from strain CBS 528.72 while one cDNA clone, LM9, was isolated from strain CBS 210.32. The Δ9-1 gene encoded a protein of 445 aa which shared 99% identity with the LM9 gene product. These proteins also showed 40–60% identity to the Δ9-desaturases (Ole1p) of other fungi and contained the three conserved histidine boxes, C-terminal cytochrome b 5 fusion and transmembrane domains characteristic of endoplasmic reticulum membrane-bound Δ9-desaturases. LM9 and Δ9-1 are therefore considered to represent the same gene (ole1). The ole1 gene was transcriptionally active in all M. alpina strains tested and its function was confirmed by complementation of the Saccharomyces cerevisiae ole1 mutation. Fatty acid analysis of yeast transformants expressing the CBS 210.32 ole1 gene showed an elevated level of oleic acid (18:1) compared to palmitoleic acid (16:1), the major fatty acid component of wild-type S. cerevisiae. This indicated that the M. alpina Δ9-desaturase had a substrate preference for stearic acid (18:0) rather than palmitic acid (16:0). Genomic clone Δ9-2 (ole2) also encoded a protein of 445 aa which had 86% identity to the Δ9-1 and LM9 proteins and whose ORF also complemented the yeast ole1 mutation. The transcript from this gene could only be detected in one of the six M. alpina strains tested, suggesting that its expression may be strain-specific or induced under certain physiological conditions.
Identification of structural and functional domains of the tetracycline efflux protein TetA(P) from Clostridium perfringens
Trudi L. Bannam and Julian I. Rood
The Clostridium perfringens tetracycline-resistance protein, TetA(P), is an integral inner-membrane protein that mediates the active efflux of tetracycline from the cell. TetA(P) acts as an antiporter, presumably transporting a divalent cation–tetracycline complex in exchange for a proton, and is predicted to have 12 transmembrane domains (TMDs). Two glutamate residues that are located in predicted TMD 2 were previously shown to be required for the active efflux of tetracycline by TetA(P). To identify additional residues that are required for the structure or function of TetA(P), a random mutagenesis approach was used. Of the 61 tetracycline-susceptible mutants that were obtained in Escherichia coli, 31 different derivatives were shown to contain a single amino acid change that resulted in reduced tetracycline resistance. The stability of the mutant TetA(P) proteins was examined by immunoblotting and 19 of these strains were found to produce a detectable TetA(P) protein. The MIC of these derivatives ranged from 2 to 15 μg tetracycline ml−1, compared to 30 μg tetracycline ml−1 for the wild-type. The majority of these mutants clustered into three potential loop regions of the TetA(P) protein, namely the cytoplasmic loops 2–3 and 4–5, and loop 7–8, which is predicted to be located in the periplasm in E. coli. It is concluded that these regions are of functional significance in the TetA(P)-mediated efflux of tetracycline from the bacterial cell.
Microevolutionary changes in Candida albicans identified by the complex Ca3 fingerprinting probe involve insertions and deletions of the full-length repetitive sequence RPS at specific genomic sites
Claude Pujol, Sophie Joly, Bridgid Nolan, Thyagarajan Srikantha and David R. Soll
The 11 kb complex DNA fingerprinting probe Ca3 is effective both in cluster analyses of Candida albicans isolates and in identifying microevolutionary changes in the size of hypervariable genomic fragments. A 2·6 kb EcoRI fragment of Ca3, the C fragment, retains the capacity to identify these microevolutionary changes, and when the C fragment is cleaved with SacI, the capacity is retained exclusively by a 1 kb subfragment, C1, which contains a partial RPS repeat element. The microevolutionary changes identified by Ca3, therefore, may involve reorganization of RPS elements dispersed throughout the genome. To test this possibility, hypervariable fragments from several strains of C. albicans were sequenced and compared. The results demonstrate that the microevolutionary changes identified by Ca3 are due to the insertion and deletion of full-length tandem RPS elements at specific genomic sites dispersed throughout the C. albicans genome. The RPS elements at these dispersed sites are bordered by the same upstream and downstream sequences. The frequency of recombination was estimated to be one recombination per 1000 cell divisions by following RPS reorganization in vitro. The results are inconsistent with unequal recombination between homologous or heterologous chromosomes, but consistent with intrachromosomal recombination. Two alternative models of intrachromosomal recombination are proposed: unequal sister-chromatid exchange and slipped misalignment at the replication fork.
Repeated extragenic sequences in prokaryotic genomes: a proposal for the origin and dynamics of the RUP element in Streptococcus pneumoniae
Marco R. Oggioni and Jean-Pierre Claverys
A survey of all Streptococcus pneumoniae GenBank/EMBL DNA sequence entries and of the public domain sequence (representing more than 90% of the genome) of an S. pneumoniae type 4 strain allowed identification of 108 copies of a 107-bp-long highly repeated intergenic element called RUP (for repeat unit of pneumococcus). Several features of the element, revealed in this study, led to the proposal that RUP is an insertion sequence (IS)-derivative that could still be mobile. Among these features are: (1) a highly significant homology between the terminal inverted repeats (IRs) of RUPs and of IS630-Spn1, a new putative IS of S. pneumoniae; and (2) insertion at a TA dinucleotide, a characteristic target of several members of the IS630 family. Trans-mobilization of RUP is therefore proposed to be mediated by the transposase of IS630-Spn1. To account for the observation that RUPs are distributed among four subtypes which exhibit different degrees of sequence homogeneity, a scenario is invoked based on successive stages of RUP mobility and non-mobility, depending on whether an active transposase is present or absent. In the latter situation, an active transposase could be reintroduced into the species through natural transformation. Examination of sequences flanking RUP revealed a preferential association with ISs. It also provided evidence that RUPs promote sequence rearrangements, thereby contributing to genome flexibility. The possibility that RUP preferentially targets transforming DNA of foreign origin and subsequently favours disruption/rearrangement of exogenous sequences is discussed.
Pathogenicity And Medical Microbiology
In vivo detection of Escherichia coli type 1 fimbrial expression and phase variation during experimental urinary tract infection
Carsten Struve and Karen Angeliki Krogfelt
Adhesion mediated by fimbriae is thought to play an important role in the pathogenesis of urinary tract infections (UTI) by Escherichia coli. The majority of clinical isolates of E. coli from UTI are able to express type 1 fimbriae. However, the importance of these fimbriae as a virulence factor has been controversial. To investigate the expression of type 1 fimbriae in vivo during UTI, mice were transurethrally infected with uropathogenic E. coli C175-94 and type 1 fimbrial expression was determined directly by two independent methods at 2 h, 1 d and 3 d after infection. By use of an assay combining in situ rRNA hybridization and immunofluorescence, all bacterial cells detected in urine, bladders and kidneys from mice sacrificed 1 and 3 d after onset of infection were found to express type 1 fimbriae. In contrast, the majority of cells in the suspension used for infection of mice and specimens from mice sacrificed 2 h after inoculation were found to be non-fimbriated. Similar results were obtained with a PCR assay revealing the orientation of the invertible promoter driving the transcription of type 1 fimbrial genes. Whilst the promoter in both ON and OFF positions could be amplified from the suspension used for infection and specimens from mice sacrificed 2 h after inoculation, at 1 and 3 d after onset of infection only the promoter in the ON orientation could be amplified. These results show that introduction of E. coli C175-94 into the mouse urinary tract leads to markedly enhanced expression of type 1 fimbriae.
Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
Patrick Marichal, Luc Koymans, Staf Willemsens, Danny Bellens, Peter Verhasselt, Walter Luyten, Marcel Borgers, Frans C. S. Ramaekers, Frank C. Odds and Hugo Vanden Bossche
The cytochrome P450 14α-demethylase, encoded by the ERG11 (CYP51) gene, is the primary target for the azole class of antifungals. Changes in the azole affinity of this enzyme caused by amino acid substitutions have been reported as a resistance mechanism. Nine Candida albicans strains were used in this study. The ERG11 base sequence of seven isolates, of which only two were azole-sensitive, were determined. The ERG11 base sequences of the other two strains have been published previously. In these seven isolates, 12 different amino acid substitutions were identified, of which six have not been described previously (A149V, D153E, E165Y, S279F, V452A and G465S). In addition, 16 silent mutations were found. Two different biochemical assays, subcellular sterol biosynthesis and CO binding to reduced microsomal fractions, were used to evaluate the sensitivity of the cytochromes for fluconazole and itraconazole. Enzyme preparations from four isolates showed reduced itraconazole susceptibility, whereas more pronounced resistance to fluconazole was observed in five isolates. A three-dimensional model of C. albicans Cyp51p was used to position all 29 reported substitutions, 98 in total identified in 53 sequences. These 29 substitutions were not randomly distributed over the sequence but clustered in three regions from amino acids 105 to 165, from 266 to 287 and from 405 to 488, suggesting the existence of hotspot regions. Of the mutations found in the two N-terminal regions only Y132H was demonstrated to be of importance for azole resistance. In the C-terminal region three mutations are associated with resistance, suggesting that the non-characterized substitutions found in this region should be prioritized for further analysis.
Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans
Bertrand Favre, Mark Didmon and Neil S. Ryder
Lanosterol 14α-demethylase (14DM) is the target of the azole antifungals, and alteration of the 14DM sequence leading to a decreased affinity of the enzyme for azoles is one of several potential mechanisms for resistance to these drugs in Candida albicans. In order to identify such alterations the authors investigated a collection of 19 C. albicans clinical isolates demonstrating either frank resistance (MICs ≤32 μg ml−1) or dose-dependent resistance (MICs 8–16 μg ml−1) to fluconazole. In cell-free extracts from four isolates, including the Darlington strain ATCC 64124, sensitivity of sterol biosynthesis to inhibition by fluconazole was greatly reduced, suggesting that alterations in the activity or affinity of the 14DM could contribute to resistance. Cloning and sequencing of the 14DM gene from these isolates revealed 12 different alterations (two to four per isolate) leading to changes in the deduced amino acid sequence. Five of these mutations have not previously been reported. To demonstrate that these alterations could affect fungal susceptibility to azoles, the 14DM genes from one sensitive and three resistant C. albicans strains were tagged at the carboxyl terminus with a c-myc epitope and expressed in Saccharomyces cerevisiae under control of the endogenous promoter. Transformants receiving 14DM genes from resistant strains had fluconazole MICs up to 32-fold higher than those of transformants receiving 14DM from a sensitive strain, although Western blot analysis indicated that the level of expressed 14DM was similar in all transformants. Amino acid substitutions in the 14DM gene from the Darlington strain also conferred a strong cross-resistance to ketoconazole. In conclusion, multiple genetic alterations in C. albicans 14DM, including several not previously reported, can affect the affinity of the enzyme for azoles and contribute to resistance of clinical isolates.
The relationship between Helicobacter pylori motility, morphology and phase of growth: implications for gastric colonization and pathology
Mulugeta L. Worku, Ramon L. Sidebotham, Marjorie M. Walker, Tajali Keshavarz and Q. Najma Karim
To explore the relationship between Helicobacter pylori motility, morphology and phase of growth, bacteria were isolated from antral biopsies of patients with duodenal ulcer or non-ulcer dyspepsia, and grown in liquid medium in batch and continuous culture systems. Motilities and morphologies of H. pylori in different phases of growth were examined with a Hobson BackTracker and by transmission electron microscopy. Morphologies of bacteria grown in vitro were also compared with those of bacteria in antral biopsies from patients with non-autoimmune gastritis. H. pylori had poor motility in lag phase, became highly motile in mid-exponential phase and lost motility in the decline phase of growth. Motilities of bacteria in the same phase of growth from patients with duodenal ulcer or non-ulcer dyspepsia were not significantly different. In the mid/late-exponential phase of growth bacteria had helical morphologies and multiple polar flagella, typical of H. pylori in the gastric mucus layer. In the decline phase of growth bacteria shed flagella, and had precoccoidal or coccoidal morphologies. These findings support the view that helical and coccoidal H. pylori are in different phases of growth with different roles in gastric colonization, indicate that bacterial motility per se is unlikely to be a determinant of H. pylori pathology, and suggest that H. pylori in the antral mucus layer is in a state of continuous (exponential phase) growth.
Trichomonas vaginalis interactions with fibronectin and laminin
Marie-Laure Crouch and John F. Alderete
The sexually transmitted protozoan Trichomonas vaginalis cytoadheres to vaginal epithelial cells and causes contact-dependent cytotoxicity which, when combined with the normal exfoliation process, leads to erosion of the epithelium, which may allow trichomonads into extracellular matrix and basement membrane sites. Therefore, the association of T. vaginalis with immobilized fibronectin (FN) and laminin (LM) on cover-slips was examined. Binding of live parasites to coated cover-slips was time- and parasite-density-dependent. Coincubation with an inhibitor of trichomonad cysteine proteinases resulted in an increased attachment of parasites to FN but had no effect on binding to LM, denoting that protease activity influenced optimal FN associations. Further, 20 h mid-exponential phase trichomonads placed in fresh culture medium for 3 h gave higher levels of binding to FN, suggesting that changes during growth in vitro to T. vaginalis organisms affect maximal levels of binding to FN. Extended incubation with substrates diminished the capacity of parasites to bind FN and LM. Treatment of live organisms with periodate reduced binding to LM but not FN, suggesting a role for carbohydrates. In addition, trypsinization of live parasites decreased numbers bound to both substrates. Placement of trypsinized parasites in medium for 2 h fully regenerated binding to FN but not LM. Incubation of trypsinized parasites with cycloheximide abrogated regeneration of attachment to FN, affirming a role for synthesized surface proteins in FN binding. Importantly, the T. vaginalis adhesin proteins that mediate cytoadherence, and iron, a factor that regulates adhesin synthesis, were not involved in FN and LM recognition. These results suggest a role for surface proteins and carbohydrates in trichomonal associations with FN and LM, respectively.
The site-specific integration of genetic elements may modulate thermostable protease production, a virulence factor in Dichelobacter nodosus, the causative agent of ovine footrot
Gabrielle Whittle, Garry A. Bloomfield, Margaret E. Katz and Brian F. Cheetham
The Gram-negative anaerobe Dichelobacter nodosus is the causative agent of footrot in sheep. The authors have previously characterized two genetic elements, the intA (vap) and intB elements, which integrate into the genome of D. nodosus. In the virulent strain A198 there are two copies of the intA element. One copy is integrated into the 3’ end of the tRNA-ser GCU gene, close to the aspartokinase (askA) gene, and the second copy is integrated into the 3’ end of the tRNA-ser GGA gene, next to the polynucleotide phosphorylase (pnpA) gene. In this study, a new genetic element was identified in the benign strain C305, the intC element, integrated into the 3’ end of the tRNA-ser GCU gene, next to askA. The intC element was found in most D. nodosus strains, both benign and virulent, which were examined, and was integrated into tRNA-ser GCU in most strains. Between the askA and tRNA-ser GCU genes, a gene (designated glpA), was identified whose predicted protein product has very high amino acid identity with RsmA from the plant pathogen Erwinia carotovora. RsmA acts as a global repressor of pathogenicity in E. carotovora, by repressing the production of extracellular enzymes. In virulent strains of D. nodosus the intA element was found to be integrated next to pnpA, and either the intA or intC element was integrated next to glpA. By contrast, all but one of the benign strains had intB at one or both of these two positions, and the one exception had neither intA, intB nor intC at one position. The loss of the intC element from the virulent strain 1311 resulted in loss of thermostable protease activity, a virulence factor in D. nodosus. A model for virulence is proposed whereby integration of the intA and intC genetic elements modulates virulence by altering the expression of glpA, pnpA, tRNA-ser GCU and tRNA-ser GGA.
Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa
Ana Alonso, Ester Campanario and José L. Martı́nez
Pseudomonas aeruginosa is one of the most important opportunistic pathogens involved in nosocomial infections, cystic fibrosis patients included. Hospital isolates frequently present multidrug-resistance (MDR) phenotypes as the consequence of constant antibiotic selective pressure. The kinetics of emergence of P. aeruginosa MDR mutants under antibiotic selective pressure indicated that long-term incubation in the presence of the bacteriostatic antibiotic tetracycline increases the mutation rate per cell per day of P. aeruginosa PAO1 by several orders of magnitude. The tetracycline-resistant mutants obtained were stable, showed decreased susceptibility to antibiotics belonging to different structural families, and contained an outer-membrane protein not present in the wild-type P. aeruginosa strain PAO1. These data are consistent with the hypothesis that incubation in the presence of tetracycline favours the emergence of MDR mutants in P. aeruginosa. The results are relevant for understanding the rapid emergence of antibiotic-resistant mutants among bacterial populations during infections. Their relationship to other models of increased mutagenesis under stress is discussed with respect to the adaptive mutation phenomenon.
Physiology And Growth
The entomopathogenic fungus Metarhizium anisopliae alters ambient pH, allowing extracellular protease production and activity
Raymond J. St Leger, Judd O. Nelson and Steven E. Screen
Ambient pH regulates the expression of virulence genes of Metarhizium anisopliae, but it was unknown if M. anisopliae can regulate ambient pH. Mutants of M. anisopliae altered in production of oxalic acid were evaluated for the interrelationship of ambient pH, buffering capacity added to media, growth, and generation of extracellular proteases and ammonia. Wild-type and acid-overproducing mutants [Acid(+)] grew almost as well at pH 8 as at pH 6, but acid-non-producing [Acid(−)] mutants showed limited growth at pH 8, indicating that acid production is linked to the ability to grow at higher pH. Production of ammonia by M. anisopliae was strongly stimulated by low levels of amino acids in the medium when cells were derepressed for nitrogen and carbon. Likewise, although Aspergillus fumigatus and Neurospora crassa produced some ammonia in minimal media, addition of low levels of amino acids enhanced production. Ammonia production by A. fumigatus, N. crassa and M. anisopliae increased the pH of the medium and allowed production of subtilisin proteases, whose activities are observed only at basic pH. In contrast, protease production by the Acid(+) mutants of M. anisopliae was greatly reduced because of the acidification of the medium. This suggests that alkalinization by ammonia production is adaptive by facilitating the utilization of proteinaceous nutrients. Collectively, the data imply that ammonia may have functions related to regulation of the microenvironment and that it represents a previously unconsidered virulence factor in diverse fungi with the potential to harm tissues and disturb the host’s immune system.
Candida albicans and Yarrowia lipolytica as alternative models for analysing budding patterns and germ tube formation in dimorphic fungi
Ana B. Herrero, M. Carmen López, Luis Fernández-Lago and Angel Domı́nguez
The site for bud selection and germ tube emission in two yeasts, Candida albicans and Yarrowia lipolytica, was analysed. Both dimorphic organisms display different patterns of budding, which also differ from those described for Saccharomyces cerevisiae. C. albicans, which is diploid and (until now) lacks a known sexual cycle, buds in an axial budding pattern. During the yeast–hypha transition induced by pH, serum, N-acetylglucosamine (GlcNAc) or temperature, germ tube emergence occurs at approximately 50% in a polar manner, while the other 50% of cells show non-polar germ tube emission. Y. lipolytica, in which most of the natural isolates are haploid and which has a well characterized sexual cycle, buds with a polar budding pattern independently of the degree of ploidy. Germ tube emission during the yeast–hypha transition in both haploid and diploid cells generally occurs at the pole distal from the division site (bipolar). The addition of hydroxyurea (HU), an inhibitor of DNA synthesis, also produces different effects. In its presence, and therefore in the absence of DNA synthesis, the yeast–hypha transition is completely abolished in Y. lipolytica. By contrast, in C. albicans germ tube emission in the presence of HU is similar to that observed in control cultures for at least 90 min under induction conditions. These results demonstrate that, rather than a single developmental model, several models of development should be invoked to account for the processes involved in the morphological switch in yeasts (the yeast–hypha transition).
Involvement of glutathione in the regulation of respiratory oscillation during a continuous culture of Saccharomyces cerevisiae
Douglas B. Murray, Frank Engelen, David Lloyd and Hiroshi Kuriyama
Respiratory oscillation occurred during aerobic continuous culture of Saccharomyces cerevisiae. During oscillation, phase-related changes in NAD(P)H and GSH levels occur. Perturbation of oscillation and inhibition of respiration occurred when GSH or GSSG was injected; however, there was a phase delay in perturbation in the case of an injection during high respiration. The perturbation phase delay was not apparent when a combination of dl-buthionine-(S,R)-sulphoximine, GSH and 5-nitro-2-furaldehyde was injected. Perturbation by GSH injection caused the intracellular GSH concentration to increase, the GSSG concentration to decrease and the cessation of ethanol uptake. NAD(P)H during perturbation was inversely related to dissolved oxygen. Perturbation by calcium pantothenate and pyridoxal-HCl caused a period of enhanced respiration before oscillation returned. These results suggest that the NAD+/NADH redox is not directly involved in oscillation control and regulation involves glutathione metabolism. Possible regulation points include alcohol dehydrogenase inhibition and/or respiratory-chain inhibition.
Morphogenesis is coordinated with nuclear division in germinating Aspergillus nidulans conidiospores
Steven D. Harris
Germinating Aspergillus nidulans conidiospores switch to polarized apical growth following an initial period of isotropic expansion. At the same time, they re-enter the nuclear division cycle. The relationship between spore polarization and nuclear division was investigated by testing the effect of cell cycle inhibitors and temperature-sensitive cell cycle mutations on spore morphogenesis. On rich media, it was found that spore polarization is delayed if completion of the first mitosis is blocked. The observed delay may be dependent upon the activity of the mitosis-promoting NIMA kinase. An additional mechanism appears to prevent polarization as the spore progresses through its first S phase. In contrast, on poor media, spore polarization does not require completion of the first mitosis. These observations suggest that spore morphogenesis is influenced by cell cycle signals in a growth-dependent manner.
Nucleosides as a carbon source in Bacillus subtilis: characterization of the drm–pupG operon
Raymond Schuch, Araik Garibian, Hans H. Saxild, Patrick J. Piggot and Per Nygaard
In Bacillus subtilis, nucleosides are readily taken up from the growth medium and metabolized. The key enzymes in nucleoside catabolism are nucleoside phosphorylases, phosphopentomutase, and deoxyriboaldolase. The characterization of two closely linked loci, drm and pupG, which encode phosphopentomutase (Drm) and guanosine (inosine) phosphorylase (PupG), respectively, is reported here. When expressed in Escherichia coli mutant backgrounds, drm and pupG confer phosphopentomutase and purine-nucleoside phosphorylase activity. Northern blot and enzyme analyses showed that drm and pupG form a dicistronic operon. Both enzymes are induced when nucleosides are present in the growth medium. Using mutants deficient in nucleoside catabolism, it was demonstrated that the low-molecular-mass effectors of this induction most likely were deoxyribose 5-phosphate and ribose 5-phosphate. Both Drm and PupG activity levels were higher when succinate rather than glucose served as the carbon source, indicating that the expression of the operon is subject to catabolite repression. Primer extension analysis identified two transcription initiation signals upstream of drm; both were utilized in induced and non-induced cells. The nucleoside-catabolizing system in B. subtilis serves to utilize the base for nucleotide synthesis while the pentose moiety serves as the carbon source. When added alone, inosine barely supports growth of B. subtilis. This slow nucleoside catabolism contrasts with that of E. coli, which grows rapidly on a nucleoside as a carbon source. When inosine was added with succinate or deoxyribose, however, a significant increase in growth was observed in B. subtilis. The findings of this study therefore indicate that the B. subtilis system for nucleoside catabolism differs greatly from the well-studied system in E. coli.
Neisseria gonorrhoeae bacterioferritin: structural heterogeneity, involvement in iron storage and protection against oxidative stress
Cheng-Yen Chen and Stephen A. Morse
The iron-storage protein bacterioferritin (Bfr) from Neisseria gonorrhoeae strain F62 was identified in cell-free extracts and subsequently purified by column chromatography. Gonococcal Bfr had an estimated molecular mass of 400 kDa by gel filtration; however, analysis by SDS-PAGE revealed that it was composed of 18 kDa (BfrA) and 22 kDa (BfrB) subunits. DNA encoding BfrB was amplified by PCR using degenerate primers derived from the N-terminal amino acid sequence of BfrB and from a C-terminal amino acid sequence of Escherichia coli Bfr. The DNA sequence of bfrA was subsequently obtained by genome walking using single-specific-primer PCR. The two Bfr genes were located in tandem with an intervening gap of 27 bp. A potential Fur-binding sequence (12 of 19 bp identical to the consensus neisserial fur sequence) was located within the 5’ flanking region of bfrA in front of a putative −35 hexamer. The homology between the DNA sequences of bfrA and bfrB was 55·7%; the deduced amino acid sequences of BfrA (154 residues) and BfrB (157 residues) showed 39·7% identity, and showed 41·3% and 56·1% identity, respectively, to E. coli Bfr. Expression of recombinant BfrA and BfrB in E. coli strain DH5α was detected on Western blots probed with polyclonal anti-E. coli Bfr antiserum. Most Bfrs are homopolymers with identical subunits; however, the evidence presented here suggests that gonococcal Bfr was composed of two similar but not identical subunits, both of which appear to be required for the formation of a functional Bfr. A Bfr-deficient mutant was constructed by inserting the Ω fragment into the BfrB gene. The growth of the BfrB-deficient mutant in complex medium was reduced under iron-limited conditions. The BfrB-deficient mutant was also more sensitive to killing by H2O2 and paraquat than the isogenic parent strain. These results demonstrate that gonococcal Bfr plays an important role in iron storage and protection from iron-mediated oxidative stress.
Physiological characterization of Streptococcus bovis mutants that can resist 2-deoxyglucose-induced lysis
Daniel R. Bond, Ben M. Tsai and James B. Russell
Streptococcus bovis JB1 does not normally lyse, but stationary phase lysis can be induced by including 2-deoxyglucose (2DG) in the growth medium. Isolates deficient in glucose/2DG phosphotransferase activity (PTS−) also lysed when 2DG was present (Lys+) and this result indicated that 2DG phosphorylation via the PTS was not an obligate requirement for 2DG-induced lysis. Cells and cell walls from 2DG-grown cultures lysed faster when proteinase K was added, but glucose-grown cultures and cell walls were not affected. A lipoteichoic acid (LTA) extract (aqueous phase from hot phenol treatment) from glucose-grown cells inhibited the lysis of 2DG-grown cultures, but a similar extract prepared from 2DG-grown cells was without effect. Thin-layer chromatography and differential staining indicated that wild-type and Lys+ PTS− cells incorporated 2DG into LTA, but lysis-resistant cultures (Lys− PTS+ and Lys− PTS−) did not. LTA from lysis-resistant (Lys− PTS+ and Lys− PTS−) cells grown with glucose and 2DG also prevented 2DG-dependent lysis of the wild-type. LTA could not inhibit degradation of cell walls isolated from 2DG-grown cultures, but LTA inhibited the lysis of Micrococcus lysodeikticus (Micrococcus luteus) cells that were exposed to supernatants from 2DG-grown S. bovis cultures. Group D streptococci (including S. bovis) normally have an α-1,2 linked glucose disaccharide (kojibiose) in their LTA, but kojibiose cannot be synthesized from 2DG. This observation suggested that the kojibiose moiety of LTA was involved in autolysin inactivation. Wild-type S. bovis had ATP- as well as PEP-dependent mechanisms of 2DG phosphorylation and one lysis-resistant phenotype (Lys− PTS−) had reduced levels of both activities. However, the Lys− PTS+ phenotype was still able to phosphorylate 2DG via ATP and PEP and this result indicated that some other step of 2DG incorporation into LTA was being inhibited. Based on these results, growth in the presence of 2DG appears to prevent synthesis of normal LTA, which is involved in the regulation of autolytic enzymes.
Extracellular metal-binding activity of the sulphate-reducing bacterium Desulfococcus multivorans
Toni A. M. Bridge, Chris White and Geoffrey M. Gadd
Polarography was used to measure the copper-binding ability of culture filtrates from a range of sulphate-reducing bacteria (SRB), including pure cultures and environmental isolates. Of those tested, Desulfococcus multivorans was shown to have the greatest copper-binding capacity and this organism was used for further experiments. Extracellular copper- and zinc-binding activities of Dc. multivorans culture filtrates from batch cultures increased over time and reached a maximum after 10 d growth. The culture filtrate was shown to bind copper reversibly and zinc irreversibly. Twelve-day-old Dc. multivorans culture filtrates were shown to have a copper-binding capacity of 3·64±0·33 μmol ml−1 with a stability constant, log10 K, of 5·68±0·64 (n=4). The metal-binding compound was partially purified from culture growth media by dichloromethane extraction followed by HPLC using an acetonitrile gradient.
Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi
Walter Giordano, Javier Avalos, Rafael Fernández-Martı́n, Enrique Cerdá-Olmedo and Carlos E. Domenech
Sterols, carotenoids and gibberellins are synthesized after the reduction of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate in different subcellular compartments of the fungus Gibberella fujikuroi. Lovastatin inhibits growth in many organisms, presumably because of the inhibition of the synthesis of essential terpenoids. However, in G. fujikuroi growth of the mycelia and sterol and carotenoid content were not affected by the presence of lovastatin. Nevertheless, lovastatin did inhibit the accumulation of gibberellins in the culture medium; this inhibition, however, was counteracted by the addition of mevalonate to the medium. The conversion of HMG-CoA to mevalonate in cell-free extracts was inhibited by 10 nM lovastatin. Since G. fujikuroi apparently possesses a single gene for HMG-CoA reductase, as shown by Southern hybridization and PCR amplification, it was concluded that the biosynthesis of sterols, carotenoids and gibberellins shares a single HMG-CoA reductase, but the respective subcellular compartments are differentially accessible to lovastatin.
Systematics And Evolution
Galactomannans from the cell walls of species of Paecilomyces sect. Paecilomyces and their teleomorphs as immunotaxonomic markers
Jezabel Domenech, Alicia Prieto, Isabel Barasoaı́n, Begoña Gómez-Miranda, Manuel Bernabé and J. Antonio Leal
An alkali-extractable and water-soluble fraction (F1S) was obtained from cell walls of Paecilomyces variotii and species of the related genera Talaromyces, Byssochlamys and Thermoascus. The structure of the main polysaccharide of these fractions was studied and found to consist of a core of (1→6)-α-mannopyranose partially substituted at O-2 by chains of galactofuranose and shorter chains of mannopyranose. The differences in the regularity of the branching points and the length of the galactofuranose side chains are useful to distinguish between species. These differences were detected by immunological methods, since highly specific polyclonal antibodies were raised against these polysaccharides. Mycelium of P. variotii CBS 990.73A was stained by indirect immunofluorescence. The polysaccharides studied in this work differ from the one described for species from section Isarioidea, and this is another indication of the heterogeneity of the genus Paecilomyces.
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Volumes and issues
Volume 165 (2019)
content/journal/micro
Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria
Rosmarie Rippka, Josette Deruelles, John B. Waterbury, Michael Herdman and Roger Y. Stanier
The Aerobic Pseudomonads a Taxonomic Study
R. Y. STANIER, N. J. PALLERONI and M. DOUDOROFF
Distribution of Menaquinones in Actinomycetes and Corynebacteria
M. D. COLLINS, T. PIROUZ, M. GOODFELLOW and D. E. MINNIKIN
The structure and function of fungal laccases
Christopher F. Thurston
Quantification of biofilm structures by the novel computer program comstat
Arne Heydorn, Alex Toftgaard Nielsen, Morten Hentzer, Claus Sternberg, Michael Givskov, Bjarne Kjær Ersbøll and Søren Molin
Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set
Mangala A Nadkarni, F. Elizabeth Martin, Nicholas A Jacques and Neil Hunter
Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
Kay H. McClean, Michael K. Winson, Leigh Fish, Adrian Taylor, Siri Ram Chhabra, Miguel Camara, Mavis Daykin, John H. Lamb, Simon Swift, Barrie W. Bycroft, Gordon S. A. B. Stewart and Paul Williams
Biofilm exopolysaccharides: a strong and sticky framework
Ian W. Sutherland
R Factor Transfer in Rhizobium leguminosarum
J. E. BERINGER
Metals, minerals and microbes: geomicrobiology and bioremediation
Geoffrey Michael Gadd
Taking place at the EICC, Edinburgh from 30 March–3 April 2020. The Microbiology Society celebrates its 75th anniversary. To celebrate, Annual Conference will be extended to five days and will include the additional, high-profile Fleming Showcase.
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Fokker E (Eindecker)
Armed Monoplane Fighter / Scout
The Fokker Eindecker monoplane fighter with its synchronized machine gun introduced armed aerial combat during World War 1.
Status: Retired, Out-of-Service
Manufacturer(s): Fokker Flugzeug-Werke GmbH - Germany
Capabilities: Fighter;
Length: 23.62 ft (7.2 m)
Width: 31.23 ft (9.52 m)
Weight (Empty): 882 lb (400 kg)
Weight (MTOW): 1,345 lb (610 kg)
Power: 1 x Oberursel U.1 9-cylinder, air-cooled rotary piston engine developing 100 horsepower driving a two-bladed wooden propeller at the nose.
Speed: 87 mph (140 kph; 76 kts)
Ceiling: 11,811 feet (3,600 m; 2.24 miles)
Range: 123 miles (198 km; 107 nm)
Rate-of-Climb: 655 ft/min (200 m/min)
Operators: Austria-Hungary; German Empire; Ottoman Empire (Turkey)
As with most aircraft developed during World War 1, the Eindecker series enjoyed a relatively short period of time at the front lines. Aviation technology was ever changing to the point that aircraft designs could be made obsolete as soon as they were produced, leaving a slim window of opportunity for a single design to prove itself. This evolving face of the First World War directly influenced both aircraft design and outcomes of several campaigns fought in the skies. The Eindecker deserves particular mention as it was one of the first aircraft to bring about a taste of things to come in air warfare.
The Fokker E "Eindecker" ("Eindecker" meaning monoplane) was of a most basic monoplane design, incorporating known successful elements from previous aircraft design attempts such as a static a landing gear system, aerodynamic details and a enclosed engine. The Eindecker series had the distinction of being the first aircraft to be fitted with the deadly synchronized machine gun/ propeller system which allowed for operation of the machine gun through the spinning propeller, quite an accomplishment that led pilots to engage enemy aircraft in relative safety without the fear of stripping off the propeller blades. This single invention would lead to the period of German air dominance known simply as the "Fokker Scourge".
This new German technology was highly-touted and highly-prized when compared to that of what the Allies had to work with. The synchronized firing mechanism was so guarded by the Central Powers early in the war in fact that aircraft armed as such restricted to fighting only above or near German-held territories for fear that the technology would fall into enemy hands. In contrast, Allied pilots operated their machine guns - usually placed on the upper wing assembly from their cockpit seats (to clear the spinning propeller blades) - often at uncomfortable distances when it came to clearing jams or rearming. In some cases, these weapon systems would have to operated by way of an extension arm with one hand while the pilot was still required to maneuver the aircraft into firing position with the other. The synchronized machine gun was an advantage that played all too well into Eindecker pilot hands and was very symbolic of the technological progression being made by both sides throughout the war.
The initial design of the Eindecker series stemmed from a pre-war design designated as the M.5. Though not a spectacular aircraft in most regards (the basic design was somewhat outdated and outclassed from the outset), the Eindecker enjoyed a good mission-to-kill ratio due to the single fact of the synchronized machine gun. The seemingly simple technological feat provided the German air force with the capability to take back the teeter-tottering skies from Allied planes. In terms of handling, however, recent wind tunnel testing revealed several challenges facing the pilot in just taking off and maintaining lift with the aircraft - a testament to the mettle that these pioneers faced from their own machines.
Due to the exclusivity of the synchronized machine gun and the limited reach placed on the Eindeckers, the E-series would languish as a bomber escort or as a defensive weapon system over German-held territories. Production issues at home also held the reach of the Eindecker series overall and the aircraft would never truly reach its intended defined potential during the course of the war. Legendary German Ace Max Immelmann would be credited with the Eindecker's first kill on August 1, 1915, and his prowess would eventually lead to a dogfighting move named in his honor. By war's end, the Eindecker would reportedly be credited with achieving the destruction of no fewer than 1,000 Allied aircraft.
1 x 7.92mm Maschinengewehr MG08 OR Parabellum MG14 OR Spandau LMG 08 machine guns over forward fuselage, synchronized to fire through the spinning propeller blades.
• M.5 - Initial unarmed model by Fokker.
• M.5K ("Kleine") - Shortened wingspan.
• M.5L ("Lange") - Lengthened wingspan.
• M.5K/MG ("Maschinengewehr") - Pre-production models; armed; 5 examples.
• A.II - German military designation for unarmed M.5L models; fitted with Oberursel U.0 engine of 80 horsepower; single example.
• A.III - German military designation for unarmed M.5K; fitted with Oberursel U.0 engine of 80 horsepower.
• E.I - Initial production scout aircraft; fitted with Oberursel U.0 engine of 80 horsepower; 68 examples produced.
• E.II - Improved version; Oberursel U.1 rotary piston engine of 100 horsepower; 49 examples produced.
• E.III - Definitive production model; 2 x machine guns as optional; reinforced structure; revised mission equipment; fitted with Oberursel U.1 rotary piston engine of 100 horsepower; 249 examples produced.
• E.IV - Final production form; dimensionally larger; fitted with Oberursel U.III 14-cylinder series engine; 2 x 7.92mm synchronized machine guns over the nose as standard; 49 examples produced.
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ARMORED PERSONNEL CARRIER
Universal Carrier (BREN Gun Carrier)
Multirole Tracked Personnel / Weapons Carrier
The Bren Gun Carrier was indeed a universal design - easy to operate and produce - that over 100,000 units were produced.
Authored By: Staff Writer | Edited: 10/17/2018
Manufacturer(s): Aveling-Barford, Ford, Sentinel, Thornycroft, Wolseley - UK
Production: 113,000
Capabilities: Troop-Carrying; Utility;
Length: 12.30 ft (3.75 m)
Width: 6.89 ft (2.1 m)
Weight: 5 tons (4,318 kg); 9,520 lb
Power: 1 x Ford 8-cylinder water-cooled inline gasoline engine developing 85 horsepower at 3,500rpm.
Speed: 32 mph (51 kph)
Range: 159 miles (256 km)
Operators: Australia; Canada; New Zealand; Soviet Union (Lend-Lease); United Kingdom; United States
The Bren Gun Carrier was truly a universal system at its core. Charged with moving troops through the harshest of conditions, the smallish armored vehicle found itself fighting on a myriad of fronts. Though not a perfect vehicle by any stretch (the system was fielded without any top cover), the Bren Gun Carrier was loved by all her crews and was produced to the tune of some 84,120 units in the United Kingdom, the United States, New Zealand, Australia and Canada. The system also saw service in the Red Army and the German Army (the latter via capture).
Though universally referred to as the Bren Gun Carrier, the vehicle was actually designated as the Carden-Loyd Universal Carrier (hence other the used designation of Bren Universal Gun Carrier). As the Bren light machine gun was the standard squad support machine gun in service to the British Army, it was no wonder that the Bren Gun Carrier was fitted with one such weapon for self-defense. In essence, the Bren carrier was nothing more than an armed tractor, capable of hauling 4 to 5 personnel (or more in crucial wartime situations), supplies or wounded. Armor was relatively light throughout and, as mentioned earlier, no top cover was afforded the crew. In some cases, this covering was improvised by the crew to protect them from the elements. Steering was accomplished through use of a wheel as oppose to the levers found in tanks. This, naturally, made training of driving personnel a tad easier.
The vehicle would definitely go on to prove its worth time and again. The Ford 8-cylinder water-cooled gasoline engine provided enough hauling power on the worst of roads and in the worst of conditions. Add to this the well-designed suspension system and it becomes no wonder how this little vehicle made it into so many hands.
The Bren Gun Carrier was served with a single 7.7mm Bren light machine gun on a pintle mounting. The light machine gun could be swapped out in favor of the Boy's .50 caliber anti-tank rifle for defense and one variant in particular - the "Wasp" - was fitted with a flamethrower. Captured Bren carriers in German Army service were refitted and put back into service mounting the 37mm PaK anti-tank gun.
Bren carriers could be found on most fronts accomplishing just about any type of job including medevac, infantry support (mounting various caliber mortars), artillery tow vehicle, mobile command post and demolitions.
1 x 7.7mm BREN machine gun OR 1 x 12.7mm Boys Anti-Tank Rifle. Also any personal weapons carried by the crew. Armament configurations also included Vickers/Browning M2 machine guns, infantry mortars (2-inch, 3-inch), or PIAT launcher.
Ammunition:
Dependent on armament loadout.
• Carden-Loyd Universal Carrier - Long-form designation
• BREN Gun Carrier - Alternative Series Name
• Mortar Carrier - Outfitted with 51mm or 76mm mortar; Anti-Tank weapons tow vehicle.
• AOP Carrier ("Armored Observation Post") - Royal Artillery usage.
• "Wasp" - Flamethrower Variant of 1944; designed by R.P. Fraser.
• T16 - U.S. Army Designation
• 3.7-cm PaK auf Fahrgestell (BREN) - Captured British carriers in service with the German Army; fitted with a 37mm anti-tank weapon system.
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Why Miller-Motte
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Life After the Military at MMC
Life After the Military
For 32-year-old Kevin Atterberry, joining the Marine Corps and serving his country was a lifelong dream. Kevin worked hard in high school to graduate early and left for bootcamp three days later. He deployed on several tours around the world, including Iraq, working as a Field Radio Operator and Listed Recruiter.
After 12 years of service, Kevin decided he was ready for a change of pace. He applied for several civilian jobs but had trouble getting his foot in the door without a degree. He even thought about becoming an entrepreneur and working for himself but knew he needed additional education before taking the risk.
From the Battlefield to the Classroom
Kevin started at Miller-Motte in the Spring of 2014, registering for the Medical Billing & Coding program. “It was weird, to say the least,” remembers Kevin about going back to school. “I had been out of school for pretty much 12 years.”
Looking for a support system to help him out, Kevin found encouragement in the camaraderie of a group of military peers, each going through the same transition. “We have a huge military presence in Jacksonville. We congregated together and helped each other out. I might not have known the guy in the military, but because he was in the military we’d help each other out.”
And support came from more than just his classmates since Kevin qualified for certain military benefits as a veteran. “I was able to use my GI Bill and a lot of things were taken care of for me that I didn’t necessarily have to worry about. My GI Bill took care of pretty much everything.”
Becoming a Leader on Campus
After a few months in the healthcare program, Kevin realized the career path he chose wasn’t right for him. After talking with the staff, Business Administration was suggested based on his skills and long-term goals. Kevin made the switch and excelled.
Soon, Kevin’s natural leadership skills were in full swing. He built relationships with the staff at Miller-Motte and became a Student Ambassador. Kevin also started and became President of Miller-Motte Jacksonville’s first Phi Beta Lambda chapter (Future Business Leaders of America).
Before graduation, Kevin completed an externship at a local Jacksonville charter school, where he now works as an Operations Manager. Kevin credits his success in business to his time at Miller-Motte, “Going to school at Miller-Motte opened that door for me to be able to do something like that.”
Finding the Right School Makes All the Difference
Kevin found both the education and the experience he wanted at Miller-Motte. “It’s just been a blast. I was looking for the full college experience and although we are a smaller campus, I felt like I was still able to get the experience that I wanted.”
He also found friends in and out of the classroom. “I think a lot of students in college, not even just at Miller-Motte, do struggle with personal issues. But I felt like if need be, I could talk to my teachers and instructors about anything that was going on.”
Kevin’s advice for veterans thinking about returning to school? “Don’t wait. Get out there and do it.”
If you’re a service member looking to transition to school, visit us online to learn more. Or, one of our Admissions Representatives can walk you through military benefits, how to enroll and program start dates.
Miller-Motte College and Miller-Motte Technical College have 11 convenient locations and offer Beauty & Wellness, Business, Healthcare, Legal & Protective Services, Skilled Trades-CDL and Technology courses and programs. We also offer 100% online programs through our Wilmington location (Business Administration, Criminal Justice, IT Support Specialist and Medical Billing and Coding). All graduates have access to Career Assistance which includes guidance from our Career Services team, resume updates, workshops and more. Financial aid is available for those who qualify. The Distance Education support facility is located at the Shared Services Center, 8181 S. 48th Street, Phoenix, AZ 85044, 480-898-7000.
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Conway’s Christmas in July a Success
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Team news | Northampton Town v Millwall
Winger Worrall is back in contention for The Lions
Millwall manager Neil Harris welcomes a trio of players back to the squad for Saturday's League One encounter at Northampton Town.
The Lions, who will be backed by around 1,000 supporters at the Sixfields Stadium, have winger David Worrall available after missing the last two matches.
Mahlon Romeo and Shane Ferguson both returned to training this week unscathed following international duty with Antigua & Barbuda and Northern Ireland respectively and are included in the travelling squad.
Defenders Shaun Cummings and Shaun Hutchinson are making progress after lengthy lay-offs but are not yet ready for inclusion, whilst striker Aiden O'Brien continues his rehabilitation after picking up an injury against Rochdale.
Northampton boss Rob Page will be forced to make at least one change to his starting XI with Matt Taylor starting a three-match ban following his red card in last Saturday's 1-1 draw at League One leaders Scunthorpe United.
Gabriel Zakuani will be available again, having skippered DR Congo at the start of their World Cup qualifying campaign, while Harry Beautyman could be in contention after recovering from a slight knock.
EFL sponsors Sky Bet can't split Northampton and Millwall as both sides are priced up at 13/8 to claim victory in Saturday's clash at Sixfields.
The draw is priced up at 12/5 for this match between the Cobblers in sixth and The Lions in 19th.
Three goals have been scored in both of Millwall's last two outings and Sky Bet go 3/1 that exactly three goals are scored in this latest clash.
To view a comprehensive lists of odds, including first goalscorer markets and a scorecast option, visit Sky Bet.
If you are not travelling to Northampton for the game, don't forget that all the action from the Sixfields Stadium will be covered with full match commentary on Lions PlayerHD from 2.55pm. Updates are also available on the club's official Twitter account @MillwallFC.
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Try My46
Welcome to My46
Manage My Genome
How My46 Works
Each gene has two copies
Traits (such as eye color or risk for disease) are passed to your children by genes. Each person has two genes for each trait. One gene is from the mother and one gene is from the father.
Autosomal recessive inheritance refers to conditions caused by changes (“mutations”) in genes located on one of the 22 pairs of autosomes. Autosomes are the numbered chromosomes that are the same in all males and females. Autosomal conditions occur in both men and women and are not related to whether a person is male or female.
“Affected” people inherit two changed copies
In an autosomal recessive disorder, two changed copies of a gene are inherited—one from each of the parents—which causes the child to have the disorder. The child is called “affected” because she or he has the disorder.
“Carriers” inherit only one changed copy
A carrier has only one changed copy of the gene. They are called “carriers” of the trait because they do not show any signs of the disorder. Although they have one copy of a gene that is changed, the partner copy of the gene is working correctly, so they do not develop the disorder.
Who is “affected”
When both parents are carriers for a recessive disorder, each child has a 1 in 4 (25 percent) chance of inheriting the two changed gene copies. A child who inherits two changed gene copies will be “affected,” meaning the child has the disorder.
There is a 1 in 2 (50 percent) chance that the child will inherit one changed copy and one normal copy of the gene, and therefore be an unaffected carrier (just like the parent).
There is a 1 in 4 (25 percent) chance that the child will inherit both normal copies of a gene, and be unaffected and not a carrier.
If only one parent is a carrier and the other is not, none of the children will have the condition. But each child will have a 50 percent chance of being a carrier.
Example: cystic fibrosis
For example, cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in a gene called CFTR. If both parents are carriers, each parent can pass on the changed copy or the normal copy to their children. Children who inherit two changed copies of the CFTR gene are “affected” and have the disease cystic fibrosis.
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West London News
Resident slams 'rat-infested' fly-tip dumped next to an Ealing primary school
A foul smell is said to be overpowering the area
Sam TrueloveSenior reporter
The fly-tip and mound of rubbish first appeared in Ealing in August (Image: Rosan Bhatt)
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A "rat-infested" fly-tip has plagued a street in Ealing for more than three months.
Mattresses, bed frames and tables are among the items which have been dumped near general waste bins behind a convenience store in The Broadway, Greenford, just yards away from Stanhope Primary School.
Waste is overflowing from the bins provided, while one resident says a "foul smell" is now overpowering the area.
Ealing Council says they cannot remove the rubbish because it has been dumped on private land, but added they have taken measures to monitor the area.
Rosan Bhatt, who lives in Greenford, said he first noticed the fly-tip in August and says more items have been dumped over the past few weeks.
Hillingdon hotel's old mattresses and furniture found dumped in Iver Heath countryside
"This spot is just next to a primary school and this looks very hazardous for both school and local residents especially with rodents and the smell," the 35-year-old told MyLondon.
"There are rats running around and street drinkers around there a lot of the time.
"There are shops and houses nearby and it's horrible for everyone around there.
One resident says he has seen rats scurrying around the rubbish (Image: Rosan Bhatt)
"It's very unhygienic. It doesn't give the area a good look at all."
Mr Bhatt says he has reported the fly-tip to Ealing Council on several occasions but nothing has been done to tackle the issue.
"I and other residents have been chasing the council about this for months but they keep saying that this is a private road and the residents should clear this," he explained.
"Why are the bins not cleared properly as these belong to the council? Now residents are suffering from the foul smell and rats running around this spot, which is also just next to a primary school.
Furniture has been dumped near to the bins (Image: Rosan Bhatt)
"The council has been turning a blind eye and have not been willing to co-operate with local residents.
"We have been asking council to relocate these bins or do a deep clean of this spot now and then and prevent fly-tipping.
"Why can't the council put a warning sign and ask the bin collectors to clean the whole area properly?"
What has the council said?
Ealing Council says it has instructed the landowner to remove the rubbish.
A council spokesperson told MyLondon: “We’re sorry to hear about the problems experienced by these residents and are happy to provide advice and assistance on measures to prevent further fly-tipping, however the legal responsibility for clearing such waste from private land lies with the landowners.
“The council has issued a community protection notice on the landowner instructing them to keep it clear and secure.
"The council has also installed a gate and signage, paved part of the alley way and installed a CCTV camera to monitor the area.
"We encourage anyone who witnesses such behaviour to report it to the council immediately so we can take strong action.”
Want more news? Go to our homepage.
Got a story? Email samuel.truelove@reachplc.com.
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Republican Congressman Leading Russia Probe Says He’s Never Heard of Key Figures in the Scandal
Devin Nunes claims he’s unfamiliar with Roger Stone and Carter Page. Huh?
Washington, DC, Bureau ChiefBio | Follow
Tom Williams/AP
There were many intriguing and surprising moments at the House intelligence committee’s hearing on Monday on Russia’s election season hacks. FBI Director James Comey exploded not one but two bombshells, noting that there was no evidence to back up President Donald Trump’s claim that he had been wiretapped last year by President Barack Obama and revealing for the first time that the FBI has been conducting a counterintelligence investigation since last July of contacts between Trump associates and Russia. Meanwhile, the Republicans on the committee ignored both of these matters—and the overarching issue of Moscow waging political warfare against the United States—and instead fixated on one thing: the leak that revealed that recently ousted national security adviser Michael Flynn had apparently lied to Vice President Mike Pence about his transition-period chats with Russian Ambassador Sergey Kislyak. Yes, the GOPers were more outraged about an unauthorized release of classified information showing that a top White House aide had deceived the veep than about Vladimir Putin mounting a covert operation against the United States to help Trump become president.
After the hearings, Rep. Devin Nunes (R-Calif.), the chair of the committee, sort of shrugged when asked why the Republicans had zeroed in on this leak and said almost nothing about Putin’s assault on American democracy. Maybe it was “overemphasized,” he said. But he contended the Flynn leak was the only crime involved in this widening scandal. When a reporter noted that hacking a political party, stealing its documents, and leaking them would qualify as a crime, Nunes grinned and said: maybe it was, but that was done by a foreign actor.
When I asked Nunes whether he agreed with Trump’s recent tweet that the “Russia story” was “fake news” cooked up by Democrats, he wouldn’t provide a straight answer. What part of the Russia story was Trump referring to? he asked. I countered: Is this all made up by Democrats? Nunes replied that he didn’t know. He was, though, quick to say he has seen no evidence of any coordination between the Trump camp and the Russians during the campaign. But, as another reporter pointed out, the committee has just started its investigation. Oh yeah, Nunes said.
Nunes just told me he’s never heard of Carter Page or Roger Stone. And he’s in charge of the investigation?
— David Corn (@DavidCornDC) March 20, 2017
Here’s the video: House Intel Chmn Nunes tells @DavidCornDC he’s never heard of Carter Page or Roger Stone —via @MSNBC pic.twitter.com/y3wJeOoHUt
— Kyle Griffin (@kylegriffin1) March 20, 2017
Reporters were shaking their heads. It seemed that Nunes didn’t care that much about the hacking and didn’t realize the hearing had produced historic revelations.
Then came perhaps the weirdest moment of all. Asked whether the committee would investigate the Trump associates mentioned by Democrats during the hearing, Nunes went on about all the “names” the Democrats had mentioned. He remarked that the committee couldn’t base its investigations on media reports. He said he didn’t bother to read all the stories out there and didn’t even recognize the “names” the Democrats had tossed out.
“Really?” I asked, noting the Democrats had referred to only about five Trump associates. Oh, Nunes, said, there was much more than that. And, he reiterated that he was unfamiliar with the people who had been brought up. What about Carter Page or Roger Stone? I asked, referring to two Trump associates raised by the Democrats. (Trump identified Page during the election as a foreign policy adviser, and Page met with Russians during the campaign. Stone, a longtime Trump adviser and self-proclaimed dirty trickster, was in contact with Guccifer 2.0 and WikiLeaks, entities that released emails stolen by the Russians from the Democratic Party and John Podesta, the Clinton campaign’s chairman.)
Nunes told me he didn’t know who they were. Huh? Page and Stone—key players in the Trump-Russia scandal who appeared in many media accounts—you don’t know who they are? No, he said. Other reporters shook their heads in disbelief. Nunes was either lying or displaying reckless ignorance.
This is the guy in charge of one of the two congressional investigations probing the Trump-Russia scandal. His staff might want to send him a few clips.
Here’s the Democrats’ Best Case for a Trump-Russia Investigation
AJ Vicens
FBI Director Comey (Kind of) Calls Trump a Liar and Says Trump-Russia Links Still Being Probed
Comey: FBI Is Investigating Whether Trump Campaign Coordinated With Russia
Inae Oh
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Hereditary diseases are the price of protection against infections
Balancing selection is responsible for helping us fend off pathogens, but also for the occurrence of mutations in our genome that predispose us to hereditary diseases
Evolutionary Biology Genetics Infection Biology
Almost half our genes can be the starting point for diseases. Scientists have identified 11,000 genes that occur in the human genome in variants that can cause disease. Scientists from the Max Planck Institute for Evolutionary Biology in Plön and the Harvard Medical School have studied why such high-risk genes persist in the human genome instead of being eliminated by selection. Their analyses suggest that the continuous adaptation to new pathogens in the course of evolution has increased the diversity of our immune genes but also comes at a price. According to the researchers, such diversity also extends to neighbouring DNA segments, where it results in the persistence of harmful gene variants.
Diversity in the genome is a good thing: it has allowed us humans to adjust to changing environmental conditions during the course of evolution. Such genetic variety generates diverse combinations with each new generation and can bring with it survival advantages. Besides the many variants that have no effect or even a beneficial effect on health, there are others that make their carriers susceptible to certain diseases.
These harmful gene variants represent a survival disadvantage and should therefore have been weeded out by natural section in the course of evolution. Instead, some high-risk gene variants, such as those for Alzheimer's disease or cancer, have persisted in the population for a long time without disappearing.
A group of researchers led by Tobias Lenz and Shamil Sunyaev has studied this phenomenon and found evidence that the occurrence of harmful gene variants could be the price we pay for the genetic diversity that is otherwise highly beneficial to our survival. They analyzed a group of immune system proteins that help detect foreign molecules. The genes for these proteins contain many variable sites and occur in a number of alternative forms in the population. This diversity ensures that our immune system is able to recognize a broad range of pathogens.
A special form of selection preserves this variation within the group of immune proteins: scientists describe it as balancing selection. It arises, for example, when several alternative variants of a gene confer a survival advantage, and are therefore not eliminated by selection.
Harmful mutations don't get lost
The scientists suspect that balancing selection may sometimes also lead to the conservation of harmful gene variants. They ran computer simulations of different types of selection using the example of immune system genes. During these tests they discovered that balancing selection not only increases the diversity of immune proteins but also affects neighbouring DNA segments. There, while reducing the total number of variable sites, it increases the frequency with which these variants occur in the population – even if they are harmful.
They then compared the simulation results with data from a genetic analysis of 6,500 people. And the analysis confirmed their suspicions: As in the simulation, fewer variable sites occurred in the immediate vicinity of the immune system genes; however, the remaining variants, including harmful mutations, were relatively more common in the population.
Harmful genes are therefore able to evade natural selection. “I did expect that higher resistance to pathogens might lead to an accumulation of some harmful mutations. But the extent to which such mutations persist in the population really surprised me. It would be interesting to know how many genetic diseases in humans can be traced back to contact with pathogens we have encountered in the course of our evolution,” says Tobias Lenz, group leader at the Max Planck Institute in Plön and member of the newly founded Kiel Evolution Center.
In the next step, the researchers want to examine whether balancing selection at other sites in the genome are responsible for the fact that harmful gene variants occur so frequently in the population.
MT/HR
Dr. Kerstin Mehnert
Scientific coordinator Max Planck Institute for Evolutionary Biology, Plön +49 4522 763-233 mehnert@evolbio.mpg.de
Dr. Tobias Lenz
Group Leader Emmy Noether Group for Evolutionary Immunogenomics Max Planck Institute for Evolutionary Biology, Plön +49 4522 763-228 lenz@evolbio.mpg.de
Tobias L. Lenz, Victor Spirin, Daniel M. Jordan, & Shamil R. Sunyaev
Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection.
Molecular Biology and Evolution; epub ahead of print, 28 June 2016
Interacting mutations promote diversity
Frequency-dependent selection fosters the diversity of populations but does not always increase the average fitness of the population. more
Cancer-like metabolism makes brain grow
Brain Evolutionary Biology
A gene for brain size has promoted the growth of the human brain
Körperzellen spionieren Krankheitserreger aus
Immunobiology Infection Biology
The aryl-hydrocarbon receptor detects when bacteria increase so much in number that they become a danger to the body
Genetic diversity facilitates cancer therapy
Evolutionary Biology Medicine
Cancer patients with more different HLA genes respond better to treatment
Pathogens from the sea
Infection Biology
A marine pathogenic bacterium forms specialized cells for dissemination
Mothers’ behavior influences bonding hormone oxytocin in babies
Developmental Biology Genetics Psychology
Oxytocin is an extremely important hormone, involved in social interaction and bonding in mammals, including humans. It's well known that a new mother's oxytocin levels can influence her behavior and as a result, the bond she makes with her baby. A new epigenetic study by Kathleen Krol and Jessica Connelly from the University of Virginia and Tobias Grossmann from the Max Planck Institute for Human Cognitive and Brain Sciences now suggests that mothers' or fathers' behavior can also have a substantial impact on their children's developing oxytocin systems.
Genome editing: interview with Stefan Mundlos
Stefan Mundlos, from the Max Planck Institute for Molecular Genetics, explains why there will be no designer babies in the near future
Less genes for a life in water
Genes lost in whales and dolphins helped adapting to an aquatic environment
Genetic diversity of South America
Genetics Language Social Sciences
New study explores genetic roots of 26 populations from diverse regions and cultures of western South America and Mexico, revealing long-distance connections between speakers of the same language, and new traces of genetic diversity within Amazonia.
Stem cells moonlight to protect the stomach from bacterial invaders
Infection Biology Stem Cells
A subpopulation of stem cells releases antimicrobial peptides to defend the gastric mucosa against pathogenic bacteria
The individual microbiome – more chance than selection
Evolutionary Biology Microbiology (B&M)
The microbial community appears not to be subject to any evolutionary selection process
Those who live longer have fewer children
The time between two generations sets the price of fertility
Human ancestors invented stone tools several times
Scientists discover the oldest systematically produced stone artifacts to date
Interview with Elena Levashina on World Malaria Day 2019
Interview with Elena Levashina on the state of malaria research on World Malaria Day 2019
Does parenting hamper the sex life of male black coucals?
Behavioral Biology Evolutionary Biology
In the black coucal sex-roles are reversed: females aggressively defend their territories and males rear the young. Despite the large effort for parental care, males still find opportunities to sire young in nests of other males, although only succeed half as often as males who are “free” and do not have to tend a brood.
Genetic defects without consequences
mRNA of defective genes pushes compensation mechanism
A molecular switch for the X chromosome
Scientists elucidate how the inactivation of X chromosomes is initiated in female organisms
A peptide against cannibalism
A small molecule safeguards roundworm larvae against parental attacks
Malaria: It’s all about the mosquito
The relative frequency of two mosquito species determines the risk of transmission to humans
Organoids reveal inflammatory processes in chlamydia infections
Researchers discover how bacteria could promote inflammation and the development of ovarian cancer
Earliest animals developed later than assumed
Earth Sciences Evolutionary Biology
Ancestors of today's sponges formed 560 million years ago
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Board index » Immersive Technology Products » Oculus VR » Oculus Rift
Yeah, another FB+Oculus thread, but hold the rage
realyst2k
Sorry, another one of these threads, but I felt we needed more where the positive was extolled rather than simply provided as a comment to a dump of negativity.
It's amazing(though I suppose, depressingly not surprising) how hyperbolic the whole internet has been since the Facebook announcement.
Okay, I'll admit, it initially knocked the wind out of me. I think that's natural as I'd be amazed if ANYONE not on the inside saw this coming.
However, I did what so few people on the internet appear to ever do: read up on it.
Anyone claiming they want "Oculus to fail" because of this or that "VR is now dead" should please, and I say this as respectfully as I can, calm down and take a breath or bugger off.
*takes breath*
Anyways, as Oculus was previously, using only Kickstarted funds, there is no way they could have mass marketed this device in the way most of us would have wanted them to. So they sought investment. And they found it. A number of wealthy venture capitalist threw in money, sensing the investment opportunity. This allowed Oculus to court the likes of Carmack away from Id, build hype at a number of trade shows, consult with Valve, share details and tech at conferences, build DK2 and develop new tech to make the thing far more palatable and practical.
Major problem, of course, is most of the money they were burning through was not theirs. I'm not talking about KS money, I imagine most of that went into the manufacture and shipment of the DK1 and the initial round of trade show appearances.
Nah, most of the money belonged to a number of VCs. These people, in the end, had the leash. They were letting Palmer do his thing, Carmack do his code, etc... because it was currently working. But make no mistakes, any of these people had the ability and right to derail the whole thing if seen fit.
Now, with the Facebook deal, Facebook buys off all these angel investors. They no longer have any say. Facebook has wisely seemingly decided to let Oculus run itself independently. This means that Oculus is now technically a more independent company than they had previously been.
Beyond the consolidation of multiple overlords with multiple ulterior motives, we now have the one overlord who's taking a long view. People claim that the match is terrible because Facebook(the site) is slowly dying. It likely is, however, that's what makes this investment work. Facebook is likely branching out to secure themselves, hedging against the possible(nay likely) demise most social media sites before it have eventually succumbed to, in much the same way that Apple moved to digital media sales and consumer hardware, or how Google is investing in everything from space exploration to wearable AR kit.
If that is the case, the odds they'd tangle too deeply in what already was seeming like a good investment are severely mitigated.
Now, lets look at some other benefits the sale will bring:
* Oculus can now custom order hardware made specifically for the Rift rather than rely on cellphone leftovers. This is HUGE.
* Despite we knowing lots about this and it being popular on tech and game blogs, it's amazing how few people out there, even among those who count themselves as gamers, know about it. The exposure will be massive.
* Zuckerberg has a storied history, some of it rather...creepy. But he also tends to be a futurist. I honestly don't think he's that disaligned with Oculus' views.
* This may lead to subsidies in supply management. That is great news.
* Of all the companies rumoured to buy Oculus, let's face it, Facebook has the cleanest track record of all of them(yes, Google is included in this math).
Until we see any evidence of Facebook destroying things, we can't assume they will. We should watch and see. Neither Palmer nor anyone at Oculus have been shown to be idiots. Haven't they earned our trust by now?
As an aside, anyone jumping ship to Sony for 'ethical' reasons obviously doesn't remember half a million rootkit infected computers, the attempt to destroy the mp3 and the mp3 player market, the contributions to HDCP, the proprietary tie-in practices, the PSN security fiasco, the crackdown on any website showing a HEX string and the twisted tale of George Hotz, among others in Sony's rather long history of unethical behaviour.
Anyone wishing Google would have bought them appear to forget Google's acquisition track record.
Re: Yeah, another FB+Oculus thread, but hold the rage
But the big question remains the same as it was on day one: what's the business model? I'm not saying there isn't one, but I've not seen anyone take pencil to paper and show numerically how a $2B+ valuation is justified. Some suggest FB will derive revenues from in-HMD advertising, but given the level of risk on this acquisition FB needs 20%+ ROI per year, $400m in added profit per year. That's something like 10m helmets, each producing $40 of advertising revenue (assuming zero costs... unlikely.)
The point is: for VR to have some sort of mass adoption it needs to be profitable in the long run. Don't know if I'm blind or not, but I'm not seeing it.
VRtifacts.com
mayaman
You think people are being negative just to be negative? C'mon now, there are serious, and I mean SERIOUS concerns raised about this entire situation. One of the main ones being that the purchaser of the tech doesn't even have a viable product of any sort themselves and rely completely on ads and obtrusive tracking in order to turn a profit.
Its akin to Ford Motor Company selling out to Johnson and Johnson talcum powder company so that Johnson and Johnson can have control of the new car scent industry. WTF. What does facebook have any clue about any of this other than to turn it into an ad generating system, tracking, etc.
We all hope our fears are unfounded but if you follow history at all you'll know that they will take this technology and morph it into something that benefits FACEBOOK, not the gamer.
You say people being critical are being naive? Its actually the other way around. In the end, Facebook looks at this as a tool to grow their business. Last I checked, Facebook wasn't in the business of creating compelling games or entertainment.
V8Griff
Sharp Eyed Eagle!
The point you make about them not having a viable product is probably one very good reason to buy Oculus in the first place to quickly acquire some physical product.
Also yes it's $2bn in total but the cash that's changed hands is *only* $400m which isn't an over the top valuation for a company that has nearly $100m invested in it in one way or another and has pretty good prospects.
The few that are slamming this, and in the main they are a loud minority, would for the most part probably have never contributed anything of worth to the VR community so their loss is minimal. Once they've got bored with ranting and jump on some other bandwagon where they can feel betrayed and self righteous about something else then Palmer and the Oculus team can get back to doing what they do best creating something worthwhile.
To be honest I think the fact that Palmer took the time to answer posts and deal with some serious abuse on Reddit last night shows he does care and as far as I'm concerned it shows his integrity is intact.
3trip
mayaman wrote:
Bad analogy, the future of online social interaction is VR, lucky has even talked about making such programs before! Besides the tech needed for a good VR social app, will make for good VR gaming! Low persistence, high fps, low latency etc. a virtual environment is a virtual environment! Both kinds of software needs the same type of hardware!
...the purchaser of the tech doesn't even have a viable product of any sort themselves and rely completely on ads and obtrusive tracking in order to turn a profit
Right, so how do they go about fixing that? Right! Invest in an alternative business model! Seriously, just because their revenue to date is based on tracking and ad revenue does not mean all future investments are for the same. They very well could be setting themselves up for money in both hardware sales and licensing.
But the big question remains the same as it was on day one: what's the business model? I'm not saying there isn't one, but I've not seen anyone take pencil to paper and show numerically how a $2B+ valuation is justified.
I don't suspect the business model will change much, at least in the short term. They put a bet they could sell 2B worth of hardware, licensing and publishing deals. That's about it.
And come on, guys. Do you really expect "in-HMD advertising?" The Rift, in the end, is a computer display. It'll only have "in-HMD advertising" if the game/application in question has it.
Ryuuken24
I think people should have confidence in the product, not the people behind it, because people can be corrupted and bought off but, if the product has real power to change the world and a foundation of new tech can be build upon it, it will stand true.
Notch is kind of an idiot for not backing the hardware if he believed in it, if he did, I don't think he does. What was he waiting for to add support for it, after almost one year of usage, just excuses. He has some odd principle against Facebook, which is run by people but, he should have stayed loyal to Oculus Rift not Oculus, they can suck it. We're all just people but, not companies, they're a business looking for a profit.
In reality, the only thing I see there being a 'social media a la Facebook' bleed-through is if they develop or help develop a VR Second Life like thing. Not my cup of tea, but hardly a bad thing for VR in general.
Ryuuken24 wrote:
I think too many people put too much stock in Notch as some kind of prophet. To his credit, he's done lots of philanthropy and is probably a really cool guy. But he also backed the OUYA: Hardly a massive success story. The guy has one good game out(in Java....blech) and I do wish him continued success. But I hardly think he's be-all end-all of the next big thing.
And again, to his credit, based on what I've read of him, I doubt he'd think of himself as a prophet either.
MSat
Golden Eyed Wiseman! (or woman!)
Facebook's bread and butter is obviously facebook.com, but that doesn't necessarily mean that any new project or company they acquire has to further that end. It's diversification, and it's probably wise for them in the long run. It's probably safe to think of it as similar to how XBox isn't used as a platform to serve Windows and Office. This VR thing might just end up being huge, so it could be quite a good investment, especially since it's still early to get their foot in the door for what amounts to be a drop in their bucket of cash.
JonR
Tone wrote:
Short-term it's the same as Oculus had, sell VR goggles. In the long term, it's to start providing various ad-driven VR services. Due to the acquisition of Oculus, Facebook is now in a position where they can both provide the service, as well as the required hardware, while profiting from both. The services would be filled with your regular Facebook goodness, advertisement and datamining and what not, but as long as Facebook services isn't the only thing you can use your goggles for, I don't see a problem with that.
Facebook bought Oculus to try and salvage a demographic they are losing in droves. That is the bottom line.
Facebook bought Oculus to make money, that's the bottom line.
Great Ars Technica writeup:
http://arstechnica.com/gaming/2014/03/w ... ebook-era/
FR3D
Location: Bavaria
The money earns Palmer and his co funders only.
So the 2.3billion $ are NOT for developing a better rift or custom panels.
Palmers words are worthless now, because he is just another employee of Zuckerberg now.
Zuckerberg has to spend additional billions of dollars if he really wants to develop custom panels.
the oculus rift company has not more cash than before and the old 'boss' Palmer has not the last word regarding all important decisions.
so things are getting worse ...
i'm loving the rift the same way i'm hating FB - so what should i do now ???
best regards ...
best regards FR3D
FR3D wrote:
Nothing different whatsoever. Nothing's really changed, at least not yet and there is zero, and I mean zero, indication this will change anytime soon.
Another good writeup at Polygon:
http://www.polygon.com/2014/3/26/554934 ... st-for-now
OzOnE2k10
Some great points in your first post, @realyst2k.
I'm looking to reserve judgement about this until we learn more of the details.
It can only really be a good thing for VR, as long as Facebook leave Oculus completely alone to get on with things as they originally intended.
I am wondering how they could possibly get their own "custom" LCD / OLED panels made though?
It would take FAR more than $2 Billion to start any sort of manufacturing, so I'm guessing it would be more a case of getting an existing panel manufacturer involved?
Think about the amazing optics and tracking they could now get made though.
The CV1 could give a real other-Worldly experience like nothing we've even seen before.
Not to mention VERY low-latency high-refresh 4K panels, and obviously a lot of AR stuff added.
That's where I think it's really headed, and that's what makes the most sense for Facebook - Augmented Reality.
They are basically looking to integrate the whole social media thing into AR, so that with their face recog stuff (face.com), it will then tag people in real-time.
Messaging will work similarly to Google Glass, the "goggles" will shrink right down, virtual cinema might take off, and all sorts of stuff is possible now.
Don't get me wrong, I'm not a FB shill by any means, and I'm still a bit disappointed by the buy-out.
I was hoping that Oculus would be able to go it alone for a LOT longer than this, and they seemed to be doing very well by themselves.
(especially with super-brains like Carmack on board.)
It would have made more sense if nVidia or someone similar had bought Oculus, but then I'm sure we'd still get plenty of outcry about it. lol
So there's a question - if nVidia or AMD could have fronted the cash to buy Oculus outright, would people still been quite so negative?
Remember, almost all of the initial tech advances in the World come from the military, including VR, so it could have been worse. :p
(well, if you're on the Internet at all, you're already being spied on by multiple entities, so I wouldn't loose sleep over the Facebook thing.)
OzOnE.
colocolo
oh...yeah... NSA is watching me masturbating everyday.....
Last edited by colocolo on Wed Mar 26, 2014 12:30 pm, edited 1 time in total.
OzOnE2k10 wrote:
Obviously, that was speculation(though Palmer did say something to that effect on Reddit as well). My take on it is they now have the 'credit' required to sign a deal with OLED manufacturers for long-term supply relationships. Something that would have been impossible with their previous situation. Again, pure speculation on my part/
*drool*
Interesting thought, using VR development to further AR development. Would seem to be one of the likeliest crossovers with Facebook's existing products.
I think that's where the initial gut-punch got me. It feels as if the 'experiment' of the plucky company which rose from Kickstarter resulted in "yet another large corporate buyout", though in retrospect, it likely wasn't realistic to believe otherwise given the ambitions.
[target acquired, missile dispatched]
OH yes , Intel, AMD or Nvidia would have been a great partners of oculus.
None of my friends (all german engeneers) use or like FB. So my guess is -"the less educated the more use of FB".
( but these people are not firm in computing or VR )
Are you kidding? Iribe and Palmer will sure use this billions to buy custom panels for company they don't even own.
It's like when Westwood and Bioware was acquired by EA all over again.
They will be just fine, guys! EA just owns them! They can keep developing independently otherwise!
Sure, sure.
Zuckerberg is not so stupid to turn the Rift into Facebook VR immediately. Wait two-three years. Noone will able to stop him.
Nice new account btw.
Time to make those super high res wafer-based CMOS micro LED displays
JonR wrote:
LOL you just said what I said, or am I missing something. Trying to save their meat and potatos demographic would bring them money would it not? Its a fact that Oculus is losing teens and 20 somethings at a record pace, far greater than they are recruiting them.
Oculus is their try to get them back.
So basically you just verified what I said.
By all means, if OVR manages to develop an eye tracking system for foveated rendering and CV1 in Brigade i would never mind if OVR now is named Oculus Facebook.
ss248 wrote:
Are you kidding? Facebook will surely invests 2 billion to buy a company, yet won't invest in panels to make their investment work.
It's like when Instagram and Whatsapp was acquired by Facebook all over again.
Zuckerberg is not so stupid as to think that you'd have to make the Rift locked down for it to work as a Facebook service device. There's no reason for him to, as a open device isn't mutually exclusive to a Facebook device. The opposite in fact.
You're making a definitive statement on how they're going to make money, something we're in no position to do reliably. The assumption that Facebook will use the Rift to bolster their traditional Facebook model is a bit silly in my opinion, because the two aren't really compatible if you ask me. I'd wager that Facebook will use the Oculus to launch their own VR services, branching in to new territory. I don't see how they could use the Oculus to try to convince people that don't want to to use traditional Facebook.
You're making a statement on how they're going to make money, something we're in no position to do reliably. The assumption that Facebook will use the Rift to bolster their traditional Facebook model is a bit silly in my opinion, because the two aren't really compatible if you ask me. I'd wager that Facebook will use the Oculus to launch their own VR services, branching in to new territory. I don't see how they could use the Oculus to try to convince people that don't want to to use traditional Facebook.
Huh? Obviously they are going to go in a different direction than traditional facebook format, its a VR headset. I thought people here had common sense enough to put 2+2 together.
Facebook will destroy Oculus. It will be molded and formed into a vehicle to distribute ads, track users for advertising purposes and to collect data. That is what Facebook does and that is their only stream of revenue. You think they bought Oculus to create compelling entertainment? Why would they do that? That costs money, money they have already outlayed in order to obtain this technology.
They will mold Oculus into a vehicle to do what facebook does now, just in a shiny new wrapper. you can kiss the dreams of the Rift being what it was. Thats gone.
Aside from your bile-spewing, please address my [citation needed] with a citation rather than just more "They'll do this because I KNOW they will! Praise my precognition!"
Yeah, except this is a software company buying an unrelated hardware company as opposed to a competing game company buying their competition...and that the medium is different(games vs hardware/software)...Exactly like it, except nothing like it except the words "acquired" and the use of "software".
a) So what? By then we'll have a VR headset.
b) How does one turn what is effectively a computer monitor into Facebook-the-page? Seriously, people are saying this everywhere. Exactly how on Earth is this supposed to work, pray tel?
I have about 50 posts and started the account shortly after backing the Rift on Kickstarter. I'm neither a senior nor do I post that often(and leave large gaps) but if you're implying I'm a shill or something, I'm a rather precognitive one, aren't I? Grow up.
That write-up on Polygon was very good too btw.
It outlines the fact that people initially started raving about the iPod / iPhone / iPad, and anything else that had a half-eaten Apple on the back.
And then when Google wanted to get into the mobile OS market, many people were sceptical. Now they hold a massive market share, and are very popular.
Personally I don't like Apple as a company, and my only phone for about 18 months was an iPhone 3, so I'm not completely ignorant of their products.
It's more about a company's ethics and past form, and the way they try to force more purchases of Apps and tie you into only THEIR music store or whatever.
I never wanted to use Facebook for many years until I discovered some great retro computing groups on there about two years ago.
Now I check for Facebook updates almost every day, and have made some great friends on there who I hope to meet up with for a beer soon.
The recent "poor choices" of Google when it comes to YouTube have made me wary too, but that kind of panned out OK in the end (kind of).
So, the Polygon article put it well when it said not to be too negative about a buy-out by a large corporation this early on.
While the Facebook acquisition may not make complete sense yet, remember that Google started off as just another search engine (back when Altavista, DogPile, Ask Jeeves, Yahoo were still popular. hehe).
Now Google IS search for a large majority of PC and mobile users around the World.
I certainly still set my browser home page to Google, and I've been using Chrome exclusively for about a year now.
The future of this investment could be amazing, and the face recognition buy-out does suggest a lot of AR stuff on the horizon.
Let's pray that Zuckerberg (and his "heavies") don't squash our VR dreams by forcing adverts or by stopping Oculus doing what they do best - ie. creating kick-ass hardware and software solutions that will continue to amaze anyone who tries them.
I now wonder what the VR devs, and the big game companies who invested into Oculus are thinking now?
Here are a few opinions, and they seem mostly positive so far...
http://www.polygon.com/2014/3/25/554758 ... s-reaction
Facebook / Oculus on CNN right now. This is weird. lol
Facebook will destroy Oculus. It will be molded and formed into a vehicle to distribute ads, track users for advertising purposes and to collect data.
That is what Facebook does and that is their only stream of revenue. You think they bought Oculus to create compelling entertainment? Why would they do that?
You're predicting the future based on an assumption of behaviour which would be rather stupid. I don't like Zuck much either, but give him some credit. If Facebook's ONLY income is from a source most predictions and trends are predicting will be harder to maintain in the future, isn't it far more likely acquisitions such as this are aimed at diversifying the portfolio? But fine, obviously, like a cartoon villain, a company can only do one thing ever for it's entire lifespan. It's why Nokia is still making rubber boots and IBM wooden calculator boxes.
That costs money, money they have already outlayed in order to obtain this technology.
Wouldn't shoehorning the Rift into something it obviously isn't cost even more money?
Currently enjoying my Nintendo playing cards.
realyst, you should be more like your name. No one is saying they're a cartoon villain, but precedence speaks VOLUMES! Precedence of such acquisitions and mergers usually end up with a empty husk of the purchased company, picked at like vultures on the plains of Africa. Or, the end product neutured to serve its new masters.
Thinking otherwise to me is not very "realystic"
Note my liberal use of [citation needed]. We have zero precedence of a gigantic social networking company buying a virtual reality startup. "Acquisitions" is one heck of a large umbrella with which to extrapolate future trends.
Seriously, find me one relevant example of this happening that has more in common than "I've seen a company buyout destroying a smaller company." I've seen people hit by cars. Not every car is destined to hit a pedestrian.
And again, I may be totally off base in my optimism. The future may indeed be grim. Fact is, however, we don't know this yet.
We have to see how this plays out before we declare absolutes in what is an unprecedented buyout.
The precedence in the case of Facebook is Instagram and Whatsapp. Where are their empty husks or neutered products?
Hope you're right realyst, really do. But I've been in business now in corporate America for 25 years. I've been a part of 5 mergers or acquisitions and every time, the company that was bought was gutted to suit the needs of the purchasing company. Now my industry is not gaming, but the model still applies.
We'll see, I'm not optimistic.
realyst2k wrote:
Today: Mar 26, 2014
Nice "shortly after" (7 months +) then.
I see people keep bringing up Instagram and Whatsapp.
The difference is that facebook bought them for userbase. And that was not so long ago, they don't have time to screw good-working project yet.
But data mining already in place and ads coming to instagram pretty soon.
Facebook bought Oculus not for userbase.
There are two points of view going around when someone is telling people not to freak out
It's not possible to use the Oculus Rift for Ad/Spying purposes
You're fool.
I trust Facebook not to use the Oculus Rift for Ad/Spying purposes
I'm tired of this bullsh*t already. I'm out.
Bingo on the not enough time to screw things up.
A bit of dissonance: The acquisition PR leads one to believe that the Zuck deal came out of the blue in the last couple of weeks. Somehow doesn't ring true when you realize that one of the major VC investors, Marc Andreessen, also sits on the board of directors of Facebook. Gets a bit incestuous when Marc A snags a big chunk of Mark Z's $2B. This also seems to clarify just why Marc A put $75m into Oculus. Did the Facebook deal really come out of thin air?
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OSHA Closes Citation from Fire That Killed Firefighter: Officials
Published at 12:39 pm on August 14, 2015
Officials from the Hartford Fire Department said the state’s OSHA division closed the citation issued after finding violations in the wake of the first line of duty death the department had in 40 years.
State and federal officials began investigating after firefighter Kevin Bell died on Oct. 7, 2014 during a fire on Blue Hills Avenue.
State labor leaders handed the city citations for five serious violations pertaining to safety issues within the Hartford Fire Department, including with problems with breathing apparatus testing, and outdated air packs.
The department previously said the fines were reduced 20 percent – from $5,000 to $4,000 -- in response to the department adopting measures to address safety concerns.
Now, fire officials said Connecticut Occupational Safety and Health has dropped the citation and the fire department demonstrated all improvements were completed prior to July 28, including selection of new fire and heat resistant hoods.
"The Department is continuing to partner with CONN-OSHA to identify opportunities to enhance the safety of our men and women." a statement from the fire department says.
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J Bone Miner Res. 2002 Dec;17(12):2281-9.
Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls.
Kontulainen S1, Sievänen H, Kannus P, Pasanen M, Vuori I.
The Bone Research Group, UKK Institute for Health Promotion Research, Tampere, Finland.
Bone characteristics of the humeral shaft and distal radius were measured from 64 female tennis and squash players and their 27 age-, height-, and weight-matched controls with peripheral quantitative tomography (pQCT) and DXA. The players were divided into two groups according to the starting age of their tennis or squash training (either before or after menarche) to examine the possible differences in the loading-induced changes in bone structure and volumetric density. The used pQCT variables were bone mineral content (BMC), total cross-sectional area (TotA) of bone, cross-sectional area of the marrow cavity (CavA) and that of the cortical bone (CoA), cortical wall thickness (CWT), volumetric density of the cortical bone (CoD) and trabecular bone (TrD), and torsional bone strength index (BSIt) for the shaft, and compressional bone strength index (BSIc) for the bone end. These bone strength indices were compared with the DXA-derived areal bone mineral density (aBMD) to assess how well the latter represents the effect of mechanical loading on apparent bone strength. At the humeral shaft, the loaded arm's greater BMC (an average 19% side-to-side difference in young starters and 9% in old starters) was caused by an enlarged cortex (CoA; side-to-side differences 20% and 9%, respectively). The loaded humerus seemed to have grown periosteally (the CavA did not differ between the sites) leading to 26% and 11% side-to-side BSIt difference in the young and old starters, respectively. CoD was equal between the arms (-1% difference in both player groups). The side-to-side differences in the young starters' BMC, CoA, TotA, CWT, and BSIt were 8-22% higher than those of the controls and 8-14% higher than those of the old starters. Old starters' BMC, CoA, and BSIt side-to-side differences were 6-7% greater than those in the controls. The DXA-derived side-to-side aBMD difference was 7% greater in young starters compared with that of the old starters and 14% compared with that in controls, whereas the difference between old starters and controls was 6%, in favor of the former. All these between-group differences were statistically significant. At the distal radius, the player groups differed significantly from controls in the side-to-side BMC, TrD, and aBMD differences only; the young starters' BMC difference was 9% greater, TrD and aBMD differences were 5% greater than those in the controls, and the old starters' TrD and aBMD differences were both 7% greater than those in the controls. In summary, in both of the female player groups the structural adaptation of the humeral shaft to long-term loading seemed to be achievedthrough periosteal enlargement of the bone cortex although this adaptation was clearly better in the young starters. Exercise-induced cortical enlargement was not so clear at the distal radius (a trabecular bone site), and the study suggested that at long bone ends also the TrD could be a modifiable factor to build a stronger bone structure. The conventional DXA-based aBMD measurement detected the intergroup differences in the exercise-induced bone gains, although, measuring two dimensions of bone only, it seemed to underestimate the effect of exercise on the apparent bone strength, especially if the playing had been started during the growing years.
10.1359/jbmr.2002.17.12.2281
Absorptiometry, Photon
Bone Density*
Humerus/diagnostic imaging*
Racquet Sports*
Radius/diagnostic imaging*
Tomography, X-Ray Computed
Bone Density - MedlinePlus Health Information
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Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004661. doi: 10.1002/14651858.CD004661.pub3.
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
Doyle LW1, Crowther CA, Middleton P, Marret S, Rouse D.
Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Locked Bag 300, 20 Flemington Rd, Parkville, Victoria, Australia, 3052. lwd@unimelb.edu.au
Epidemiological and basic science evidence suggests that magnesium sulphate before birth may be neuroprotective for the fetus.
To assess the effects of magnesium sulphate as a neuroprotective agent when given to women considered at risk of preterm birth.
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2008).
Randomised controlled trials of antenatal magnesium sulphate therapy in women threatening or likely to give birth at less than 37 weeks' gestational age. For one subgroup analysis, studies were broadly categorised by the primary intent of the study into "neuroprotective intent", or "other intent (maternal neuroprotective - pre-eclampsia)", or "other intent (tocolytic)".
At least two authors assessed trial eligibility and quality, and extracted data.
Five trials (6145 babies) were eligible for this review. Antenatal magnesium sulphate therapy given to women at risk of preterm birth substantially reduced the risk of cerebral palsy in their child (Relative Risk (RR) 0.68; 95% Confidence interval (CI) 0.54 to 0.87; five trials; 6145 infants). There was also a significant reduction in the rate of substantial gross motor dysfunction (RR 0.61; 95% CI 0.44 to 0.85; four trials; 5980 infants). No statistically significant effect of antenatal magnesium sulphate therapy was detected on paediatric mortality (RR 1.04; 95% CI 0.92 to 1.17; five trials; 6145 infants), or on other neurological impairments or disabilities in the first few years of life. Overall there were no significant effects of antenatal magnesium therapy on combined rates of mortality with cerebral palsy, although there were significant reductions for the neuroprotective groups RR 0.85; 95% CI 0.74 to 0.98; four trials; 4446 infants, but not for the other intent subgroups. There were higher rates of minor maternal side effects in the magnesium groups, but no significant effects on major maternal complications.
The neuroprotective role for antenatal magnesium sulphate therapy given to women at risk of preterm birth for the preterm fetus is now established. The number of women needed to be treated to benefit one baby by avoiding cerebral palsy is 63 (95% confidence interval 43 to 87). Given the beneficial effects of magnesium sulphate on substantial gross motor function in early childhood, outcomes later in childhood should be evaluated to determine the presence or absence of later potentially important neurological effects, particularly on motor or cognitive function.
Review: antenatal magnesium sulphate prevents cerebral palsy in preterm infants. [Evid Based Med. 2009]
Update of
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. [Cochrane Database Syst Rev. 2007]
10.1002/14651858.CD004661.pub3
Central Nervous System Diseases/prevention & control*
Cerebral Palsy/mortality
Cerebral Palsy/prevention & control
Fetal Death/prevention & control*
Magnesium Sulfate/therapeutic use*
Neuroprotective Agents/therapeutic use*
Premature Birth*
Neuroprotective Agents
MAGNESIUM SULFATE - Hazardous Substances Data Bank
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How to optimize teleworkers
New spins on work/life balance
Attitudes about telework are changing
Telework in corporate America
By Toni Kistner and Jeff Zbar
Network World |
Wonder what the other guys are doing? Take a peek inside 10 firms' remote work programs.
How does telework play in your company? Is working away from the office widely embraced, tolerated or frowned upon? The bigger question: Is telework saving your firm any money - in facilities costs, increased productivity, or in employee recruitment, retention and training? To find out, we interviewed executives at more than a dozen companies about their programs. The results were surprising.
Today's telework takes many forms. There are formal programs dictated by corporate management to cut costs; grass-roots programs created to meet employee needs or demands; and occasional or informal telework - employees work at home after-hours, on a snow day, or when a manager says it's OK. Most firms with teleworkers also have full-time remote (or virtual) employees, often living in another state.
Schering-Plough, with 30,000 worldwide employees, has a program in its clinical research division. Forty percent of its 500 staffers telework formally two or three days per week or work remotely. The company doesn't account for occasional teleworkers. "I have no idea how many there are, but I'd imagine the numbers are quite high," says project manager Gail Smith.
Similarly, HP, which has offered telework and other flexible work arrangements since 1990, says it doesn't "centrally track the use of work/life options." However, it estimates that between 10% and 50% of its workforce teleworks one day per week or on an ad hoc basis.
While there's nothing wrong with not tracking informal telework, it might prevent companies from optimizing cost savings.
Telework newcomer NASCO, an Atlanta national account services company, launched a small program in October 2002 with 60 project managers working one day per week from home. While NASCO lauds the increased productivity and employee morale, it doesn't expect to save money.
[ Check out our hands-on reviews: 5 top hardware-based Wi-Fi test tools and Mojo wireless intrusion prevention system. ]
"We did a cost-benefits analysis, looking at everything from the cost of computer equipment to coffee, lighting, cubicles, you name it," says Mira Moss, NASCO's vice president of human resources. "Once employees are working three days a week at home, we could recoup some office space. But it's one thing to say you can get rid of these cubes, another to look at the business that's contracted for. We have a 10-year lease. So even if we got rid of them, we're still going to pay. With telework, the only thing we're saving on is the occasional cup of coffee."
Schering-Plough saves on office space but receives no direct cost savings, because the company owns its facility. But telework will keep the firm from having to lease additional space as it grows, Smith says.
Across the gulf, AT&T, IBM, Morgan Stanley, Sun and others are realizing huge facilities cost savings from telework. While most won't share specifics, Sun says it saves $150 million per year. Industry sources say KPMG saves $66 million, and Ernst and Young well over $100 million.
AT&T's program is one of the oldest, largest and most successful. Last year, it began a big push to "virtual officing," sending 400 middle managers home for good, as a way to reduce costs, increase output, and improve job and career satisfaction, says Joe Roitz, AT&T's telework director. To ease the process, the firm added a virtual office piece to its intranet, so workers and managers could handle the process themselves. Rather than set up a free-standing virtual office portal, AT&T links workers to the relevant departments such as IT, facilities and purchasing, to get set up.
"We're creating a business benefit and structuring the enterprise for the knowledge economy, which means arranging it around networks, not buildings," Roitz says.
Cigna, which employs 38,000 people, saves $3,000 per year, per employee in office space, and reports a 30% decrease in turnover and 15% increase in productivity among teleworkers. Such numbers are driving the health insurance company to increase its teleworkers by 15% annually.
Nortel and Merrill Lynch continue to promote telework, despite grim downsizing. Nortel says it's laid off only 7% of its 13,000 teleworkers between 2000 and 2001, compared with the tens of thousands of employees fired in the same period.
Baxter BioScience and Lockheed Martin Information Technology (LMIT) - and NASCO - each reported management resistance to telework. Baxter, which has no formal program, increased its number of teleworkers by 25% in December 2002, when the company relocated several hundred employees to a new facility 30 miles away, increasing the commute for many.
"At the time, our [HR] department was supportive. But now I hear they're trying to restrict the number of people teleworking," says Dominique Endicott, senior manager of clinical data management. "For now, managers are implementing telework into our groups until we're told to stop," she says.
In contrast, LMIT met management resistance by creating a structured program. The firm, which provides IT consulting for the military, was urged by employees to institute a telework program in 1997.
"We faced traditional thoughts about how employees wouldn't be as effective [out of the office]" says Joe Wagovich, director of communications. In response, LMIT implemented stringent policies on eligibility, as well as guidelines for how often teleworkers would check e-mail and call the main office for messages. Although most LMIT consultants' jobs aren't suited to telework, the company supports those that are with equipment such as notebook PCs and cable modems.
"We know there needs to be a balance between home and work life. "It took us a while to understand the culture, to learn telework can be managed and increase productivity - in the right setting," he says. "People have come over and said, yeah, telecommuting isn't so bad."
Telework snapshot A down economy isn’t keeping firms from promoting telework. The savvy ones are using it to cut costs and gain a competitive edge.
Company Employees What’s new
AT&T 25,000 teleworkers; 5,000 remote workers Firm is moving hundreds of teleworkers into virtual offices as a way of reducing costs and increasing output.
Baxter BioScience clinical research department 35 teleworkers, 12 remote workers Number has increased 25% in December 2002, when firm moved corporate office.
Cigna 3,100 teleworkers Added 1,100 new teleworkers in 2001. Plans to increase the number to 5,000 by year-end; goal is 15% annually.
Eli Lilly and Company 90 formal teleworkers, 14,000 informal Number has increased 30% from last year.
HP 10% to 50% telework No changes; mature program.
LexisNexis 2,600 teleworkers Program continues to grow, but more slowly than its inception eight years ago.
Lockheed Martin IT About 350 teleworkers Firm’s attitude. LMIT found telework can be managed and increase productivity — in the right setting.
NASCO About 60 teleworkers, 40 remote workers The program, which was launched in October 2002.
Nortel 13,000 teleworkers Number has decreased only 7% between 2000 and 2001, despite massive employee layoffs.
Schering-Plough clinical research division 130 teleworkers, 70 remote workers Added 25 teleworkers in 2002. Instituted a waiting list.
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Global Village Nanaimo, a non-profit, has opened its seasonal store at Terminal Avenue and Campbell Street. Photo submitted
Fair trade store in Nanaimo will be open until Christmas
Global Village Nanaimo, a non-profit, opens seasonal store at Terminal Avenue and Campbell Street
BY MARJORIE STEWART
Shoppers in Nanaimo can support fair trade at a local non-profit seasonal store.
The seasonal Global Village Nanaimo fair trade store is now open at 111 Terminal Ave., the yellow building on the corner at Campbell Street. The store is stocked with foods, housewares, accessories, baskets and much more, mostly directly imported from small producer groups.
Caroline Hodson, GVN president, said, “Most of our customers are just happy with the variety and the quality and our assurance that the people who made the goods got an agreed fair price. But we also get asked how we know the producers get the benefit, about how certification and labelling work.”
There is confusion between certifier/labellers. The World Fair Trade Organisation is firm that fair trade must be introduced along the value chain from producer to buyer, and now guarantees fair trade with its logo. The Latin American small producers organization uses its own certification program with its own SPP symbol, which it sees as “a bridge of communication and collaboration between small producers and consumers.”
Some older-established logos now certify larger producers in hope of introducing some fairer practices on a larger scale.
GVN is part of the global development aid network through membership in the B.C. Council for International Co-operation which is a member of the Canadian Council for International Co-operation .
“GVN is committed to purchasing from small producers, many of whom are not certified. We know that the handcrafts trade is close behind food and beverages as an income generator for those most in need. We apply the 10 fair trade principles of the World Fair Trade Organization when we import directly and we put our reputation behind the products we sell,” said Hodson.
Feds dropped ball with WWI anniversary tributes: historians
$1,000 worth of cosmetics stolen from Nanaimo drugstore
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