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Venezuelan army helicopter crashes near Caracas, killing seven
5 May 2019 06:11 (UTC+04:00)
A Venezuelan military helicopter crashed close to Caracas on Saturday morning, killing all seven people on board, the Defense Ministry said in a statement.
The helicopter was to fly from Caracas, the capital, to the west-central state of Cojedes when it “went to ground,” the Defense Ministry said, adding that authorities were investigating the cause of the crash.
President Nicolas Maduro was in Cojedes on Saturday to watch a series of army drills, which, in televised speeches, he said demonstrated Venezuela’s military readiness against what he called the threat posed by the United States.
Maduro accuses the U.S. government of trying to foment a coup against him by backing opposition leader Juan Guaido, who denounces Maduro as illegitimate and has assumed a rival presidency.
“I profoundly regret this incident and express my heartfelt condolences to their relatives and friends,” Maduro said later on Twitter.
Guatemala severs diplomatic ties with Venezuela
Other News 17 January 08:58
Venezuelan president recognizes National Assembly's new board of directors
Other News 6 January 06:01
Venezuela opposition pushes to re-elect Guaido as congress chief
Taiwan top military official missing after helicopter made emergency landing
China 2 January 08:28
At least 1 soldier killed as Venezuelan opposition attacks military unit - Caracas
Maduro says US, Colombia prepare provocation, mobilises Venezuelan army
Other News 30 November 2019 08:16
President Ilham Aliyev met with LUKOIL president in Davos (PHOTO)
Politics 21 January 23:48
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Castle Point (UK Parliament constituency)
Borough constituency
for the House of Commons
Boundary of Castle Point in Essex
Location of Essex within England
88,011 (2011 census)[1]
64,562 (December 2010)[2]
Major settlements
Canvey Island, South Benfleet
Current constituency
Rebecca Harris (Conservative)
South East Essex
Overlaps
European Parliament constituency
Castle Point is a constituency[n 1] represented in the House of Commons of the UK Parliament.[n 2]
2 Boundaries
3 Changes proposed by the Boundary Commission
4 Constituency profile
5 Members of Parliament
6.1 Elections in the 2010s
8 Notes and references
This seat was created for the 1983 general election from the former seat of South East Essex. It comprised the District of Castle Point which was formed from the former Urban Districts of Canvey Island and Benfleet and includes Canvey Island, Hadleigh, South Benfleet, and Thundersley.
In all but one election, it has been won by a Conservative candidate, passing to Labour once, in the 1997 election. The former MP defeated in 1997, Bob Spink, regained the seat in 2001. He was re-elected in 2005 but subsequently resigned from the Conservative Party on 22 April 2008. Spink briefly joined UKIP,[3] but resigned the whip shortly afterwards and sat as an Independent MP.[4] In the 2010 election, Spink lost in Castle Point to the Conservative candidate, Rebecca Harris.
After the 2017 election Castle Point has the largest Conservative majority of any constituency to have elected a Labour MP in the 1997–2010 government, at 42.2%.
Boundaries[edit]
Since its creation, the Castle Point constituency has been contiguous with the boundaries of the district council of the same name. The seat is one of only a very few that were unchanged by the boundary reviews which came into effect in 1997 and 2010, having seen population growth in line with the average seat (which is slightly larger), including development in the designated development plans of the Thames Gateway.
Changes proposed by the Boundary Commission[edit]
The Boundary Commission for England submitted their final proposals in respect of the Sixth Periodic Review of Westminster Constituencies (the 2018 review) in September 2018 which would reduce the total number of MPs from 650 to 600. Although the proposals were immediately laid before Parliament they were not brought forward by the Government for approval. Accordingly, they will not come into effect for the 2019 election due to take place on 12 December 2019, which will be contested using the constituency boundaries in place since 2010.
The Commission has recommended that the two wards comprising the town of Pitsea in the Borough of Basildon be transferred from South Basildon and East Thurrock, with two wards comprising the town of Hadleigh be transferred to Southend West (to be renamed Southend West and Hadleigh).[5]
Constituency profile[edit]
The seat is coterminous with the Castle Point local authority, taking its name from Hadleigh Castle and Canvey Point, and covering the Canvey Island at the seaside end of the Thames Estuary plus a segment of the adjoining mainland.
In 2001, Castle Point was characterised by skilled manual workers, commuters and the self-employed. Levels of home and car ownership in Hadleigh and Canvey were very high while social deprivation was relatively low.[6]
Of all the constituencies of the UK, it has one of the lowest levels of graduates.[7]
Members of Parliament[edit]
Member[8][9]
1983 Sir Bernard Braine Conservative
1992 Bob Spink Conservative
1997 Christine Butler Labour
Apr 2008 UKIP
2010 Rebecca Harris Conservative
Elections[edit]
Elections in the 2010s[edit]
General election 2019: Castle Point[10]
Conservative Rebecca Harris 33,971 76.7 +9.5
Labour Katie Curtis 7,337 16.6 -8.5
Liberal Democrats John Howson 2,969 6.7 +4.4
26,634 60.1 +17.9
44,277 63.6 -0.8
Conservative hold
This was the largest Conservative vote share at the 2019 general election.[11]
Conservative Rebecca Harris 30,076 67.3 +16.4
Labour Joseph Cooke 11,204 25.1 +11.2
UKIP David Kurten 2,381 5.3 −25.9
Liberal Democrats Tom Holder 1,049 2.3 +0.6
44,710 64.4 −2.3
See also: Opinion polling in United Kingdom constituencies, 2010–15 § Castle Point
General election 2015: Castle Point[13][14]
UKIP Jamie Huntman [15] 14,178 31.2 +31.2
Labour Joe Cooke [16] 6,283 13.8 −0.9
Green Dom Ellis[17] 1,076 2.4 +2.4
Liberal Democrats Sereena Davey [18] 801 1.8 −7.6
8,934 19.7 +2.7
General election 2010: Castle Point[19][20][21]
Conservative Rebecca Harris 19,806 44.0 −4.3
Independent Save Our Green Belt Bob Spink 12,174 27.0 N/A
Labour Julian Ware-Lane 6,609 14.7 −15.7
Liberal Democrats Brendan D'Cruz 4,232 9.4 −0.9
BNP Philip Howell 2,205 4.9 N/A
Conservative Bob Spink 22,118 48.3 +3.7
Labour Luke Akehurst 13,917 30.4 −11.7
Liberal Democrats James Sandbach 4,719 10.3 +2.5
UKIP Neil Hamper 3,431 7.5 +4.3
Green Irene Willis 1,617 3.5 N/A
8,201 17.9 +15.4
45,802 65.9 +7.5
Labour Christine Butler 16,753 42.1 −0.3
Liberal Democrats Billy Boulton 3,116 7.8 −1.4
UKIP Ronald Hurrell 1,273 3.2 N/A
Independent Douglas Roberts 663 1.7 −1.0
Truth Party Nik Searle 223 0.6 N/A
985 2.5 N/A
39,766 58.4 −13.7
Conservative gain from Labour
Labour Christine Butler 20,605 42.4 +18.4
Conservative Bob Spink 19,462 40.1 −15.5
Liberal Democrats Michael Baker 4,477 9.2 −9.9
Referendum Hugh Maulkin 2,700 5.6 N/A
Independent Linda Kendall 1,301 2.7 N/A
1,143 2.3 N/A
Labour gain from Conservative
Conservative Bob Spink 29,629 55.6 −4.3
Labour David Flack 12,799 24.0 +5.0
Liberal Democrats Allan Petchey 10,208 19.2 −1.9
Green Irene Willis 643 1.2 N/A
Conservative Bernard Braine 29,681 59.9 +1.4
Social Democratic Anne Bastow 10,433 21.1 −3.7
Labour William Deal 9,422 19.0 +2.3
Conservative Bernard Braine 26,730 58.5 N/A
Social Democratic Anne Bastow 11,313 24.8 N/A
Labour Lynne Cunningham 7,621 16.7 N/A
15,417 33.7 N/A
Conservative win (new seat)
List of Parliamentary constituencies in Essex
Notes and references[edit]
^ A borough constituency (for the purposes of election expenses and type of returning officer).
^ As with all constituencies, the constituency elects one Member of Parliament (MP) by the first past the post system of election at least every five years.
^ "Castle Point: Usual Resident Population, 2011". Neighbourhood Statistics. Office for National Statistics. Retrieved 16 February 2015.
^ "Electorate Figures – Boundary Commission for England". 2011 Electorate Figures. Boundary Commission for England. 4 March 2011. Archived from the original on 6 November 2010. Retrieved 13 March 2011.
^ "Ex-Tory MP Spink defects to UKIP". BBC News. 22 April 2008.
^ "Tory? UKIP? Now I'm just an inde says MP Bob". Echo.
^ Boundary Commission for England, 2018 Review, Associated consultation documents (September 2018). "Final recommendations report". Archived from the original on 2019-02-15. CS1 maint: multiple names: authors list (link)
^ "Local statistics - Office for National Statistics". www.ons.gov.uk.
^ Kelly, Jon (June 27, 2016). "Was there a Brexit graduate gap?" – via www.bbc.co.uk.
^ "Castle Point 1983-". Hansard 1803-2005. UK Parliament. Retrieved 2 February 2015.
^ Leigh Rayment's Historical List of MPs – Constituencies beginning with "C" (part 3)
^ "Castle Point Parliamentary constituency". BBC News. BBC. Retrieved 18 November 2019.
^ http://researchbriefings.files.parliament.uk/documents/CBP-8749/CBP-8749.pdf
^ "Castle Point". Election 2017. BBC News. Retrieved 11 June 2017.
^ "Election Data 2015". Electoral Calculus. Archived from the original on 17 October 2015. Retrieved 17 October 2015.
^ "Castle Point parliamentary constituency - Election 2017" – via www.bbc.co.uk.
^ "Cllr Jamie Huntman". UKIP Essex. 12 July 2014. Retrieved 17 January 2015.
^ "UK ELECTION RESULTS: CASTLE POINT 2015".
^ "Candidates". Eastern Green Party. Archived from the original on 2015-03-11. Retrieved 14 March 2015.
^ "List of selected candidates". Liberal Democrats. 26 March 2015. Retrieved 9 April 2015.
^ "Election Data 2010". Electoral Calculus. Archived from the original on 26 July 2013. Retrieved 17 October 2015.
^ "Archived copy" (PDF). Archived from the original on 2011-09-27. Retrieved 2010-05-05. CS1 maint: archived copy as title (link)
^ "BBC NEWS – Election 2010 – Castle Point". BBC News.
^ "UK General Election results April 1992". Richard Kimber's Political Science Resources. Politics Resources. 9 April 1992. Archived from the original on 11 August 2011. Retrieved 2010-12-06.
nomis Constituency Profile for Castle Point — presenting data from the ONS annual population survey and other official statistics.
Parliament of the United Kingdom
Cardiff South and Penarth Constituency represented by the Father of the House
Old Bexley and Sidcup
Constituencies in the East of England (58)
Basildon and Billericay
Central Suffolk and North Ipswich
Harwich and North Essex
Hertford and Stortford
Hitchin and Harpenden
Mid Bedfordshire
Mid Norfolk
North East Bedfordshire
North East Cambridgeshire
North East Hertfordshire
North West Cambridgeshire
North West Norfolk
Norwich North
Rochford and Southend East
South East Cambridgeshire
Southend West
South Suffolk
South West Bedfordshire
South West Norfolk
West Suffolk
Luton North
Luton South
Norwich South
East of England European constituency:
Coordinates: 51°32′N 0°34′E / 51.54°N 0.57°E / 51.54; 0.57
Retrieved from "https://en.wikipedia.org/w/index.php?title=Castle_Point_(UK_Parliament_constituency)&oldid=934572603"
Parliamentary constituencies in Essex
United Kingdom Parliamentary constituencies established in 1983
Wikipedia articles incorporating an LRPP-MP template with two unnamed parameters
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ENCORE SEEKERS HOME
ENCORE CAREER HANDBOOK
Higher Education – Innovative Encore Programs
Colleges and universities are increasingly offering encore programs to help older adults acquire new knowledge and skills that employers need, gain credentials, and prepare for transitions to roles with social impact. Increasing numbers of individuals have already returned to college to prepare for encore careers. And, innovative higher education encore programs have been developed in a variety of academic divisions – continuing education, workforce development, executive and professional education, undergraduate and graduate education – and across departments – research, human resources, curriculum, advancement, career and alumni services, and student services. Learn more about these programs below.
Encore! Connecticut, University of Connecticut Department of Public Policy
Encore!Connecticut is a four-month workforce development program tailored for seasoned corporate professionals seeking to transition their skill-sets and experience into successful professional and managerial employment in the Connecticut nonprofit sector.
University of Washington EncoreU initiatives introduce UW employees and retirees to encore opportunities.
Stanford Distinguished Careers Institute
The Stanford Distinguished Careers Institute offers a year-long opportunity for about 25 Fellows individuals from all walks of life who seek to transform themselves for roles with social impact at the local, national, and global levels.
Advanced Leadership Initiative, Harvard University
Each year, through the Advanced Leadership Initiative, a select group of Fellows from diverse sectors with a track record of achievement and accomplishment comes to Harvard to transition from their primary income-earning careers and prepare for their next phase plan as change agents for society.
Ignite Institute at Pacific School of Religion
The Ignite Institute provides education and training for spiritually-rooted changemakers, excavating and communicating the transformational narratives within progressive spiritual traditions, and anchoring a network of faith communities, social justice organizations, and activists working towards economic justice.
The Encore Transition Program at Union Theological Seminary
The Encore Transition Program at Union Theological Seminary engages a diverse group of 12-15 like-minded 55+ adults in a four-month program of discernment, dialogue, and decision-making about what an “encore” stage of productive and experienced adulthood might look like.
Portland Community College, Life by Design NW
Life by Design NW supports people as they age in discovering their passion and purpose so they engage their wisdom and skills to strengthen the community and achieve personal fulfillment. lifebydesignnw.org is a portal to what’s happening in the Portland metro area for people age 50+ in life planning, working, volunteering, creating community connections, learning, and living an active life. Through our unique partnerships we are able to connect people with the resources they need to create their life by design.
Rio Salado College 50+ Encore Programs
Rio Salado College offers online teacher certification to eligible adults (age 50 and older) who are interested in re-careering and pursuing teaching positions in early childhood, elementary, secondary, special education and arts education.
University of Minnesota Advanced Careers Initiative
University of Minnesota Advanced Careers (UMAC) is for Boomers transitioning from career jobs into meaningful engagement. It connects intergenerational learning, social impact, and personal development.
Encore Fellowship Program, Center for Public Administration and Leadership, Hamline University
Hamline’s Encore Fellowship program provides an opportunity to learn about full-time, part-time and volunteer encore careers and to serve for two months as an Encore Fellow in a nonprofit organization.
Encore Impact, Kaleo Center, United Theological Seminary of the Twin Cities
Encore Impact is a program of the Kaleo Center. It engages a diverse group of 55+ adults in a four-month program of discernment, dialogue, and experience that emphasizes productive, social-purpose focused adulthood. The goal is to develop individual plans of encore lives in social justice and social purpose.
The Tower Fellows Program, The University of Texas at Austin
The TOWER Fellows Program will consist of approximately 25 individuals who participate in an intergenerational learning and life-changing experience. Applications are now being accepted for the 2018-2019 academic year.
Inspired Leadership Initiative, University of Notre Dame
The Inspired Leadership Initiative (ILI) is a new program for accomplished individuals who are at the end of their traditional careers and want to pivot to a next stage of life. Participants will spend an academic year experiencing intellectual immersion, local and global community engagement, and other resources.
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What if saviors forget integrity to become ‘looters’?
2000 police involved in criminal activities every year!
Gajendra Basnet
Image for Representation
KATHMANDU: The Constitution of Nepal has assigned the task of ensuring peace and security situation in the country to the police.
The police play a pivotal role in paving way for the ‘rule of law.’ Along with the investigation of crime and criminal activities, the police have to work for ‘investigation of crime and peace (security) management.
In some cases, the police themselves are found involved in illegal and criminal activities.
The data provided by the police headquarters shows that some police personnel have been found to have been involved in various social, economic and criminal activities.
Some of the police are seen in murder/killings, drug abuse, drug transactions, illegal trade of wild lives and timber, kidnap and rubbery, theft and racketeering.
The latest example of this incident is Hem Bahadur Shahi, a DSP at Area Police Office, Kohalpur, Banke. He is booked in the charge of asking a he-goat from Tarun Dal leader Keshar Khadka.
Two policemen were found involved in the group rape of two young women in June 2019. Two policemen Pateswor Yadav and Prem Khadka were involved in the incident.
Prior to it, Dilli Raj Bista, an SP was dismissed from the service for his force negligence in the investigation of rape and murder case of Nirmala Panta. Together with him Jagadish Bhatta, an inspector in the same unit was dismissed on October 25, 2018.
Earlier, Gambhir Chand, a head constable working in the Area Police Office, Fulbari, Majhkatuwa was arrested on the charge of rape in Dang.
Last year, Shyam Khatri, an SSP at the Tribhuvan International Airport (TIA), was arrested on the charge of his involvement in the smuggling of 33 kg gold.
After getting clues about Khatri’s connection with the gang of smugglers, a Central Investigation Bureau (CIB) team had arrested him.
Khatri was made a suspect in the Sanam Shakya murder case executed in Urlabari. The murder case found Govinda Raj Niraula, a DIG, Bikash Raj Khanal, an SP and Sanjaya Bahadur Saud, a DSP involved in the case.
Chandra Singh Bhat, an Assistant Inspector of Police and constable Pushkar Shah, both working at the Balaju Police unit, were banded with Rs 500,000 in October 2017. This made Nabin Krishna Bhandari, then DSP and 4 more policemen suspect in the case causing their dismissal.
In February 2017, Madan Bahadur Malla, a sub-inspector and Manohar Budha, a constable, raided at a gambling station at Kalanki, chased the gamblers and looted around Rs 450,000.
As minor mistakes committed by individuals of such organizations are also to draw the public attention, the suspected ones in the serious crime should never be spared.
Two more cases that drew public concern in 2017 were the Durbarmarga rape case and the Itahari rape case. The police were found involving in secretly suppressing the cases rather than investigating it and booking the culprit.
These are some representative cases. As per the Police Headquarter’s data, 1,800 police personnel are booked in many criminal involvements among which 249 are dismissed from the service.
The last 5 years statistics reveal that 10 thousand 5 hundred 11 police have gone through some sort of disciplinary actions.
According to DIG Bishworaj Pokharel, the spokesperson of the police, the staff forbearing disciplinary actions have been the staff from a lower level up to DIG and the cases involving them range from rape, drug abuse, gold smuggling, theft, rubbery, etc.
Coercive actions against the violators: When and how many?
The Police Headquarters data reveals that 2,100 police are found involved in criminal activities every year when 300 of them get dismissed from service for such involvement.
DIG Bishwo Raj Pokharel believes such disciplinary actions taken against the wrongdoers help to make the organization stronger, firmer and more trustworthy.
The news about the fugitives’ involvement in organized crime is not new, however, the shocking revelation about senior officers as abettors is likely to stake the organization’s accountability and trustworthiness.
“The persons who have been sworn in office as public servants and saviors seem to be committed to earning money by hook or crook. This has not only defamed the organization but also resulted in deterioration of the service,” regrets Jaya Bahadur Chand, former AIG of Police.
Chand thinks it’s high time to ponder at the cause of police in such activities.
Clause 113 (A) of Nepal Police Regulations has the provisions regarding the actions against the police not abiding by the prevalent laws.
The actions range from warning, clarification, to dismissal from service declaring ineligible for future services or dismissal from post declaring eligible for tenure in government service in the future.
Nepal Police Act provisions that the police dismissed from the post are not eligible to get additional amenities except Provident Fund and Insurance whereas the ones removed from the post are eligible to get gratuities, pensions, etc.
The involvement of security forces, assigned the responsibility of maintaining law and order situation and ensuring peace and security, in the criminal activities defames not only the concerned institution, but it also has long term dire impacts as the trustworthiness and credibility in such institution will deteriorate for a long time.
As questions are raised about such instances in all four types of security forces, it’s high time that the concerned authorities curbed such activities in time.
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NPR document not mandatory for KYC process, clarifies RBI
After creating a flutter by announcing a National Population Register (NPR) document as proof for its Know Your Customer (KYC) procedure, the Reserve Bank of India has clarified that NPR letter is not mandatory for the KYC process.
“As per RBI’s directives, not only the letter issued by the National Population Register, even other documents like passport, driving licence, Aadhaar number, voter identity card and NREGA job card are also officially valid documents (OVDs) for KYC purpose,” said a TOI report quoting the central bank’s response.
Submission of NPR letter is not mandatory, it added.
According to bankers, this is not new. NPR letter is considered as one of the valid documents for KYC since 2017.
Recently, the central bank in a Telugu daily advertisement asked customers to submit KYC details before January 31, 2020. The list of KYC documents that it sought included the NPR letter. It further warned banks customers of not being able to transfer money in case of failure.
This advertisement created unrest among the people, many of whom took to Twitter to question the move.
The NPR letter kerfuffle comes at a time when there are ongoing protests against the Citizenship (Amendment) Act (CAA) and the proposed National Register of Indian Citizens (NRIC).
The enrolment for NPR will be done along with the houselisting phase of Census 2021 during April to September 2020 in all the States and Union Territories, except Assam.
KYC, NPR, RBI
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Jitendra has spent more than seven years in journalism. He had been founding-member of content startups such as Newzstreet, Indiasamvad and iamwire. Prior to that he did long, deeply reported feature stories for The Indian Express and handled desk at IANS. Among the things that excite him is wonder about life and its creative potential in every sphere.
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The TeamColin Welsh2019-12-10T18:27:19+00:00
The Fitness Team
Hector BonesFounder
Hector has wanted to transform peoples’ health and well-being since his teens. This led him to create elevate Health & Performance in 2015.
Hector Bones
Hector Bones is the Personal Training and Physical Therapy entrepreneur who founded elevate Health & Performance™. He holds a B.S. in Kinesiology from Temple University and he has been a successful certified fitness trainer since 2009. Before founding elevate, Hector trained clients and taught group classes at The Sporting Club at The Bellevue.
Hector’s philosophy is optimal fitness at every age. So he builds individual holistic programs helping us all become and remain our best selves.
Since 2015, it’s been Hector’s goal to make a team to revolutionize Personal Training and Physical Therapy in Philadelphia.
Chris ByiersCertified Fitness Trainer
Chris played semi-pro European football. And was a software architect before returning to his love of motivating people to get fit.
Chris Byiers
Chris became a certified fitness trainer after a successful career as a software architect. Also, he played semi-professional European football. This left him wanting an active and social profession. While pursuing his passion, Chris studied physiology and fitness at the American Academy of Personal Training. And, he graduated at the top of his class in 2009.
So, as you can imagine, his clients goals vary widely. These include increasing running speed, endurance and serious weight training. Other clients want to be able to beat their friends at flag football. Or get into their skinny jeans.
Also, Chris motivates without being abrasive. He offers firm challenging programs. But, he’s not a drill sergeant. Therefore, he focuses on meeting your goals while tailoring a program that respects your body and gets results.
And finally, Chris joined our Philadelphia Personal Training and Physical Therapy Team in 2016.
Tim HamptonCertified Fitness Trainer
Tim has a long-term interest in golf and fitness. This pointed him to exercise physiology and extensive experience in rehab training.
Tim Hampton
Growing up with sports and athletics, Tim has a passion for the health wellness that stems over 20 years. With 10 plus years of experience in training in various settings he is sure to find a way to fit exercise into your lifestyle. He understands life is a balancing act and everyone has to figure out what works for them. Tim would describe himself as a new dad that loves golf, food, and connecting with people. He takes great pride in the idea of being able to help people find positive change in their life.
College: Florida Atlantic University B.S. Exercise Science
Certifications: NSCA Certified Strength and Conditioning Specialist
(CSCS) ASCM Certified Personal Trainer (CPT)Titliest
Performance Institute Level II (TPI)NASM Golf Fitness Specialist
Natali RuzichCertified Fitness Trainer
Natali earned her degree in Kinesiology from Temple. She’s now studying to be a Physical Therapy Assistant.
Natali Ruzich
Natali competed at Temple University as a Division 1 gymnast while earning a Bachelors degree in Kinesiology, Exercise Science. Natali is currently enrolled at Harcum College, completing her degree for Physical Therapist Assistant for May 2020. She developed a love for the physical therapy and fitness field through personal experiences through out her athletic career. Core lessons for discipline, consistency, team work and dedication has driven her to become more educated towards a successful health professional.
Natali brings a ray of positive energy, always hoping to motivate and push each and every client in the right direction to reach each desired goal. She incorporates physical therapy aspects such as prehab and rehab into strength and resistance training programs for maximal benefit. She also shows an interest in continued education, towards more certifications due to an ever growing field with there always being room for improvement!
Natali has a hidden artsy talent, love drawing, reading on the beach or in a park, long walks and hikes, spending time with friends and family.
Tyler BoydCertified Fitness Trainer
Tyler played Division 1 Baseball. This solidified his interest body mechanics and physical therapy. He’s now completing his DPT.
Tyler grew up in northern New Jersey. And graduated from Seton Hall. He add the few courses he needed to embark on a Physical Therapy career at County College of Morris. And he’s currently enrolled in the Doctor of Physical Therapy program at Temple University.
Tyler’s been interested in body mechanics for years. And has been a Performance Coach for Olympic figure skaters and other elite athletes. He’s also been a Rehab Exercise Specialist and a Baseball Instructor.
He likes to give back to the community. And currently volunteers at the North Broad Physical Therapy Center.
Education/Certifications:
B.A. in Social and Behavioral Sciences from Seton Hall University. National Strength and Conditioning Association-Certified
Strength and Conditioning Specialist
Carla DudleyPractice Coordinator
Carla trained as a fine artist focusing on printmaking. She received her degree from The Pennsylvania Academy of Fine Arts.
Carla Dudley
After Graduating she worked as the head Pastry Chef at the Penn museum for two years. Carla then joined our team at elevate Health & Performance in the summer of 2018 as the practice coordinator. She also is a teacher at Friends Select in the afternoon working with children from PreK – 5th grade with a focus in art.
Justin DePermentier DPTLead Physical Therapist
Justin earned a Bachelor of Science Degree in Athletic Training before becoming a Doctor of Physical Therapy.
Justin DePermentier
Justin joins us after developing a specialty physical therapy clinic. He’s a key member or our Philadelphia Personal Training and Physical Therapy Team. Justin received his Bachelor of Science and Doctor of Physical Therapy degrees from Duquesne University.
Justin worked extensively as an NATA Certified Athletic Trainer. And he currently volunteers as a DPT and coach for the St. Joseph’s Prep hockey team.
He’s passionate about helping people return to optimum health. He’s leveraged these to gain deep experience working with athletes and an active adult population.
And like the rest of our team he’s committed to working with you one-on-one. So Justin will collaborate with you to use proven safe physical therapy practices.
He helps you to understand your body and how it works. The goal: returning you to the active life you want and to keep you healthy in the long term.
Justin’s certifications include:
NATA BOC Certified Athletic Trainer.
APTA Licensed Physical Therapist.
GRASTON Technique.
Functional Movement Systems (SFMA and FMS Certifications).
As an avid learner, Justin actively pursues continuing education. He’s attended courses in Posture Restoration and Mykniematics (at Postural Restoration Institute).
So, stop by or contact us to schedule an appointment to meet Justin. We know that you’ll be as impressed as we are.
Finally, Justin joined our Philadelphia Personal Training and Physical Therapy Practice in 2019.
Carol Huegel PT Physical Therapist
Carol’s has interests and experience across the age spectrum. This has led to training in neuro-development and vestibular rehabilitation.
Carol Huegel
Carol Huegel received her physical therapy training at University of Florida. She has been providing physical therapy services for over 30 years. And now works seasonally with our Philadelphia Personal Training and Physical Therapy Team.
An expert in many areas, Carol has extensive training and experience in neuro-development and neuro-rehabilitation. These are coupled with advanced training in vestibular rehabilitation. So, this makes Carol well-suited to attack diagnoses including vertigo, gait imbalance, concussion, stroke, traumatic brain injury, spinal disorders and progressive neurological conditions.
Carol has treated patients of all ages and conditions. Plus, like the rest of our team, she tailors treatment to their specific needs.
A respected educator, Carol has served as a clinical instructor for PT students from around the country. And she has presented extensively at physical therapy conferences both here and abroad.
Finally, Carol has a passion for horses and has integrated them into therapy. She started two not for profit organizations devoted to Hippotherapy (equine-assisted therapy). Plus, she has served on the faculty of the American Hippotherapy Association. And has been chair of the national certifying board.
So, stop by or contact us to schedule an appointment to meet Carol. We know that you’ll be as impressed as we are.
Massage Therapy Team
Lisa DubroffNCBTMB Licensed Massage Therapist
Lisa’s interest in mind-body connection led her to massage therapy. She is certified in sports, deep tissue, and Mother Massage®
Lisa Dubroff
Passionate and committed to total health and wellness, massage therapy has been the perfect balance to Lisa’s active lifestyle. Mother, runner, outdoor enthusiast, and triathlete, Lisa uses massage to support a vibrant pain free life for herself and her clients. Whether it’s alleviating muscle aches and pains from overuse or injury, or providing stress relief from life’s challenges, massage is an integral part of a total mind/body wellness program.
Lisa holds a Bachelor’s degree in Psychology from Rutgers University, is licensed by the National Certification Board For Therapeutic Massage & Bodywork (NCBTMB) and holds certifications in Deep Tissue, Sports Massage, Mother Massage, and Cupping. Lisa integrates her extensive training with her client’s goals to make each massage personal, relaxing and therapeutic. Each sessions builds on improved body awareness, which serves as the foundation to good health.
I hiked the highest peak in the Northeastern United States and at the summit could look down at the clouds surrounding Mount Washington.
I love all things dance, and if you ask nicely I will impress you with my tap skills.
I used to be a lifeguard and used my New York State boaters license to drive a pontoon boat.
I spent 2 months living without electricity and cooked all my meals over a wood burning stove.
I’ve interned at an adult inpatient psychiatric unit and on Wall Street in NYC. There were some surprising similarities.
I’ve done yoga on the top of Little Whiteface Mountain.
I did my first Triathlon after having 2 kids.
Interested in Rittenhouse Massage Therapy?
Just contact us. We’re here to help.
Dietician Counseling Team
John RickardsLead Dietician
John’s interest in fitness led him to a career in nutrition. He’s a registered and licensed dietician with a facts-based approach to your health.
John Rickards
John received his training at LaSalle University. And while he has worked in all facets of nutrition, he specializes in weight management and sports nutrition.
John has been practicing over 10 years and takes a holistic approach nutrition management. He advocates eating well – not taking radical or risky – approaches. And he encourages clients to be active to the best of their abilities. The results are steady progress to your goals.
Plus, John and his team have the ability to inspire you to try harder. He loves to educate and motivate people to live a healthy balanced life style.
He helps make nutrition and health coaching a key component or our Philadelphia Personal Training and Physical Therapy Practice.
Ashley LeeDietician
Ashley’s belief that healthier eating leads healthier lives informed her decision to become a registered dietician and health coach.
Ashley grew up in Delaware and pursued her Bachelors’ Degree in Dietetics at The University of Delaware. She is a licensed dietician in Pennsylvania. And has earned a Certificate of Training in Adult Weight Managment. Plus, Ashley’s a Certified Health Coach with The American Council on Exercise.
She has worked in variety of settings from hospitals to community nutrition programs. Ashley adapts those experiences to work tirelessly inspiring clients to improve their nutrition, exercise and food choices.
Just contact us here at elevate Health & Performance™ with any questions about our services and your health.
CONTACT US - LET'S GET STARTED
elevate Health & Performance™ Optimal Health At Every Age. You Can Live exactly the Life YOU want.
Call (215) 545-6500 to speak with a health and fitness advisor. Or email us at info@elevate.health.
Visit us at 1528 Walnut St Suite 403, Philadelphia PA 19102
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Home Unemployment Illinois Unemployment Office Locations
Illinois Unemployment Office Locations
Find the Illinois Unemployment Office Near You
Illinois (IL) unemployment office addresses for each unemployment office in the state are listed below. Find directions, the main phone number, and the fax number for the Illinois unemployment office nearest you.
Read our guide to determining eligibility for the Illinois unemployment program here.
Chicago Unemployment Office 33 South State Street, Chicago, IL (312) 793-5280
Aurora Unemployment Office 260 E Indian Trl, Aurora, IL (630) 844-8455
Danville Unemployment Office 407 N Franklin St # B, Danville, IL (217) 442-0236
Cairo Unemployment Office 2207 Poplar Street, Cairo, IL (618) 734-9034
Peoria Unemployment Office 406 Elm St # 1, Peoria, IL (309) 673113
Carlinville Unemployment Office 116 South Plum Street, Carlinville, IL (217) 854-6115
Cicero Unemployment Office 1931 South 59th Court, Cicero, IL (708) 656-7496
Pontiac Unemployment Office 741 W Washington St # 2, Pontiac, IL (815) 842-2693
Centralia Unemployment Office 325 South Poplar Street, Centralia, IL (618) 532-4741
Springfield Unemployment Office 850 E Madison St # 1, Springfield, IL (217) 782-0157
Belleville Unemployment Office 110 West Washington Street, Belleville, IL (618) 277-3012
Murphysboro Unemployment Office 223 South 13th Street, Murphysboro, IL (618) 687-2341
Rockford Unemployment Office 4302 N Main St # 108, Rockford, IL (815) 987-7657
East St Louis Unemployment Office 225 North 9th Street, East St. Louis, IL (618) 583-2300
Brooklyn Unemployment Office 312 South 5th Street, Brooklyn, IL (618) 278424
Litchfield Unemployment Office 13456 US Route 66, Litchfield, IL (217) 324-4102
Unemployment Resources
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Find out if you’re eligible for Unemployment with our free evaluation form. Enter your state to begin.
I may be directed to a licensed sales agent who can answer my questions and provide information about Unemployment. Agents are not connected with or endorsed by the U.S. government
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You’ll never beat the Irish! Big news for Ireland’s women’s soccer
Alanna MacNamee
Big news for fans of Ireland’s women’s soccer, with Dutchwoman Vera Pauw named the squad’s new manager in the wake of last night’s 2 – 0 win over Montenegro.
Vera replaces caretaker manager Tom O’Connor, who’s been at the helm since the side’s most recent boss Colin Bell resigned last June.
Vera was in attendance in a rainy Tallaght Stadium last night to watch the girls in green beat Montenegro.
The match was the opener in Ireland’s qualification campaign for the UEFA European Women’s Championship finals. The tournament is due to take place a short skip and hop across the pond in England in 2021.
We’re delighted to have Vera become the Head Coach of #IRLWNT🇮🇪
Her first game will be the #WEURO2021 Qualifier at home to Ukraine on October 8 in Tallaght Stadium#COYGIG🇮🇪 pic.twitter.com/3RcA2cOHbl
— FAIreland ⚽️🇮🇪 (@FAIreland) September 4, 2019
Putting their names on the score sheet for Ireland were 18 year-old Tyler Toland, who scored the opener from 25 yards – just seven minutes in. Ireland’s second goal came from a Kate McCabe penalty at 69 minutes.
It was comprehensive win for an impressive Irish side, although in the end the score sheet didn’t quite reflect Ireland’s domination.
Denise O’Sullivan of Ireland. Pic: Getty Images
Vera nevertheless declared herself impressed by the victory, explaining that she is excited by the challenges of taking on her new role. ‘I believe we can achieve very positive results together,’ the Dutchwoman said.
It would certainly seem that way, as Vera appears to be more than up to the task of leading the Irish ladies.
She won 89 caps as a player for the Netherlands, before a move into coaching in 1998.
Ireland starting eleven during the first game of the USWNT Victory Tour against the Republic of Ireland. Pic: Getty Images
Perhaps most impressive is Vera’s record as Netherlands coach. She took over as manager of her native side in 2004, leading the team to the semi-finals of the 2009 UEFA Championships.
Since then, Vera’s coached the Russian and South African national sides, while also working for Thailand’s FA and American club side Houston Dash.
Crystal Dunn #19 of United States and Harriet Scott #3 of Republic of Ireland. Pic: Getty Images
Speaking about Vera’s appointment, General Manager of the FAI, Noel Mooney was extremely positive, describing her as ‘a pioneer of women’s football.’
‘We hope Vera will lead our squad to our first major senior championships and will further the growth of the women’s game here in all areas,’ he added.
The Republic of Ireland women’s football team will play next against Ukraine in Tallaght Stadium on October 8th.
LGFA teams up with Lidl and Jigsaw for Youth Mental Health Awareness
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Previous articleEvil GINius: Brussels sprouts flavour gin now exists!
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Ronan Collins breaks down on air remembering ‘great friend’ Larry Gogan
Malaysian resort confirms it’s being sued by parents of Nóra Quoirin
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1) The fiery arguments between Scarlett Johansson and Adam Driver are one of the highlights of the movie.
2) The movie remains engaging thanks to three colorful divorce lawyers. The expensive and brash Ray Liotta, the swanky and flamboyant Laura Dern, and finally the bumbling Alan Alda.
1) The movie is equally pretentious like Noah Baumbach’s previous venture. There are already a dozen movies directed by Woody Allen with the same theme.
2) It should’ve been titled “Divorce Story”.
Ted: Criminal lawyers see bad people at their best, divorce lawyers see good people at their worst
Adam Driver, Alan Alda, David Heyman, Drama, Julie Hagerty, Laura Dern, Merritt Wever, Netflix, Noah Baumbach, Randy Newman, Ray Liotta, Scarlett Johansson
1) The epic finale of the 11-year-old journey culminating with the 22nd film. A journey started by Jon Favreau, led by Joss Whedon, and concluded by the Russo brothers. A rare grand emotional movie event of this generation.
2) The time travel plot enabled the screenwriters to add all the good & bad, major & minor characters from the franchise to make one final cameo in this grand finale.
3) Captain America lifting Mjolnir is got to be the most epic scene of this movie. A scene 4 years in the making.
4) A fulfilling climax for Steve Rogers.
5) Fun filled storyline with great comic-relief from Ant-Man and Thor “The Dude” Lebowski.
6) An epic finale needs an epic sacrifice. It had to be Tony Stark.
Rocket: What did you do?
Thor: I went for the head.
Alan Silvestri, Angela Bassett, Anthony Mackie, Anthony Russo, Benedict Cumberbatch, BRADLEY COOPER, Brie Larson, Callan Mulvey, Chadwick Boseman, Chris Evans, Chris Hemsworth, Chris Pratt, Christopher Markus, Cobie Smulders, Danai Gurira, Disney, Don Cheadle, Elizabeth Olsen, Emma Fuhrmann, Evangeline Lilly, Frank Grillo, Hayley Atwell, Hiroyuki Sanada, Jack Kirby, Jacob Batalon, James D'Arcy, Jeremy Renner, Joe Russo, Josh Brolin, Karen Gillan, Kerry Condon, Kevin Feige, Linda Cardellini, Marisa Tomei, Mark Ruffalo, Marvel, Maximiliano Hernández, MCU, Michael Douglas, Michael James Shaw, Michelle Pfeiffer, Monique Ganderton, Paul Rudd, Rene Russo, Robert Downey Jr., Robert Redford, Ross Marquand, Samuel L. Jackson, Scarlett Johansson, Stan Lee, Stephen McFeely, Super-Hero, Taika Waititi, Terry Notary, Tessa Thompson, Tilda Swinton, Tom Holland, Tom Vaughan-Lawlor, Ty Simpkins, Vin Diesel, William Hurt, Winston Duke, ZOE SALDANA
1) A fast-paced action-packed sci-fi flick with a lasting effect on the audiences.
2) The comparison to Limitless (2011), Akira (1988), and 2001: A Space Odyssey is inevitable. However, this movie got a life of its own.
3) Presence of legends like Morgan Freeman and Choi Min-sik.
4) Astounding CGI – especially towards the end of the movie.
1) The climax will make you ask the reason for making this movie. The ending is not ambiguous but reduces the entire movie to a science documentary with a Korean mob sub-plot.
Lucy: Ignorance brings chaos, not knowledge.
FRENCH, HOLLYWOOD, KOREAN, Movies
Amr Waked, Choi Min-sik, Luc Besson, Morgan Freeman, Pilou Asbæk, Scarlett Johansson, Sci-Fi
Vicky Cristina Barcelona (2008)
1) An ordinary story elevated by the performance of Penélope Cruz as María Elena. Notably, her screen time is less than 15 minutes.
2) Though the movie is a generic rom-com, at times it appears as a great satire on characters like Cristina who are confused about their life and sexuality.
3) The first meeting of Juan Antonio with Vicky & Cristina.Brazenly outspoken.
1) This primary plot is of little consequences. A one time watch.
Cristina: If you don’t start undressing me soon this is going to turn into a panel discussion.
Chris Messina, Christopher Evan Welch, Javier Bardem, Kevin Dunn, Patricia Clarkson, Penélope Cruz, Rebecca Hall, Rom-Com, Scarlett Johansson, Woody Allen
Under the Skin (2013)
1) An alien’s tale of self-discovery.
2) The story is ordinary and got nothing special to offer but the direction and music make this movie a chilling ride.
3) Mica Levi – the haunting soundtrack.
1) Not an entertaining movie for average moviegoer as it’s slow paced.
2) Unknown supporting cast
Deformed Man: People wind me up.
Female: How?
Deformed Man: They’re ignorant.
Jonathan Glazer, Mica Levi, Scarlett Johansson, Sci-Fi, UNDER THE SKIN
Hail, Caesar! (2016)
1) Alden Ehrenreich as Hobie Doyle : he’s a revelation
2) Jonah Hill as Joseph Silverman : Best character from the movie
1) Generic Coen Bros film , missing the cutting edge. One step away from being next lebowski.Good to see Coen Bros returning to their roots after the disaster called “Inside Llewyn Davis”.
2) Small characters were better than lead characters.
Hobie Doyle: It’s complicated.
Alden Ehrenreich, Caesar!, Channing Tatum, Coen Brothers, Comedy, Dolph Lundgren, Frances McDormand, George Clooney, Hail, Jonah Hill, Josh Brolin, Ralph Fiennes, Scarlett Johansson, Tilda Swinton, Wayne Knight
1) Crossbones fighting Cap. America
2) Return Of General Ross
3) Ant-man & Spider-man should be in a MCU movie teaming together : Paul Rudd made best of his short screen-time.
4) Berlin airport battle : Giant-Man sequence
5) Daniel Brühl : Convincing as always
6) Re-enactment of Civil War # 7 Cover Art.
1) Basically this movie core secret is Bucky responsible for killing Howard Stark
2) Martin Freeman : too less screen time
3) Tom Holland as Peter Parker : Can’t let Toby out of my head,he’ll remain the definitive Spidey.
Zemo: Mission Report: December 16, 1991.
Captain America: Civil War, Chadwick Boseman, Chris Evans, Daniel Brühl, Don Cheadle, Elizabeth Olsen, Jeremy Renner, Marvel, MCU, Paul Bettany, Paul Rudd, Robert Downey Jr., Russo brothers, Scarlett Johansson, Stan Lee, Super-Hero, Tom Holland, William Hurt
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China, India copper demand up: Barrick
Aug 2nd, 2011
Canada's Barrick Gold Corporation says copper prices are set to remain robust as industrial demand from China and India continues to rise.
The world's biggest gold miner expanded its small copper portfolio earlier this year with the $C7.3 billion ($A6.9 billion) takeover of Australia's Equinox Minerals.
Barrick also remains bullish on gold amid sovereign debt concerns around the world.
Inflation in China will further enhance demand for gold, says Barrick (Australia Pacific) Ltd regional president Gary Halverson.
"We believe the copper price will continue to be supported on the demand and supply side," Mr Halverson told the Diggers and Dealers mining conference in Kalgoorlie, Western Australia on Tuesday.
He told reporters on the event's sidelines there's growing copper demand from China and India for industrial purposes.
"Our outlook is that there would be a steady three per cent increase in copper need ... over the next several years," Mr Halverson said.
"It's a bit of a stretch to meet the current supply needs."
Barrick expects to complete an expansion study of the formerly Equinox-owned Lumwana copper mine in Zambia in the second half of 2012, with a view to doubling throughput rates.
He said the mine would produce more than 300 million pounds per annum after 2011.
"We're looking at operational improvements and efficiencies, with a focus on exploration to materially expand our resource," he said.
Lumwana had been a unique acquisition opportunity, but was not part of a wider diversification into other commodities and West Africa.
The company's focus remained gold in the Asia-Pacific region, Mr Halverson said.
Assets currently for sale were pricey, so Barrick would continue to look at acquisition opportunities, but didn't feel compelled to jump into deals.
"The overall cost of everything seems to be quite prohibitive," he said.
"The focus is to grow what we've already got."
Barrick has enough advanced stage projects around the world to increase its total gold production to nine million ounces within the next five years, from an estimated 7.6 million to 8.0 million ounces in 2011.
The company had budgeted $80 million for exploration around its Australia mines this year, Mr Halverson said.
An expansion of the company's massive Super Pit joint venture with Newmont Mining at Kalgoorlie was advancing, but it would be a long process to evaluate whether the lives of the open pit and underground operations could be extended.
Mr Halverson also said the carbon tax would cost Barrick $US12 an ounce, which was "not insignificant, but manageable".
Diggers Barrick
DHL parent Deutsche Post triples profit
Panoramic views golden Gidgee return
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The Earwolf Challenge
Earwolf Classics
Episode 9.3 — Time Crunch: Day 3
By admin, September 7, 2011 in The Earwolf Challenge
jarshall 25
I just subscribed to all 3 finalists. so there's really no problem here.
I'd love to see LDDC win, but if they don't, I'm sure they're not going anywhere soon.
minnesara 0
Thanks to @Scott and @Jeff for all the replies throughout the forums. The little reminders that you guys are just as passionate about producing these podcasts as your wolf pack is about listening to them is really nice to see.
I think I would have been one of the angrier posters if my favorite (LDDC) had packed their bags & left the kitchen this week. I understand people's feelings about the judging, but I don't envy the judges in having to make the decision.
Also, it seemed obvious that Doug and Harris had listened to earlier challenges and were more familiar with the competitors, which seemed to make them better judges. Their criticism was much more constructive and beneficial than admiring TL's 'college radio voice' or LDDC's accents. I know it'd be tough to get permanent judges for next season, but I think it would help improve the educational benefits, both for challengers as well as other podcasters listening for advice/inspiration.
DirkGently 0
@Caroline
"You give Jeff too much credit. I love him dearly, but his involvement in Earwolf has nothing to do with cleverness, either achieved or attempted."
OK OK LOL. I believe you. Honesty is hard to argue with ROFL.
If you still haven't figured it out... I had to try it a couple times off the advice of Linus...
What you do is after the paragraph, hit Return on your Mac and on the next line hold option and hit space at the same time. Then hit Return again to go to the next line to start the next paragraph. It's a pain in the ass, but It's also nice that you guys are building you're own message boards from scratch and not leaning on 'Disqus' or 'OpenID' or any of the other systems. I think this has a lot of potential. I'd like to see options in the future for e-mail notifications of responses, and easy methods for replying to a quote and kinda 'captioning' that quote within the response. I think a lot of traffic on message boards can be attributed to people having the option of 'subscribing' to a thread. I'm sure you're guys will get there soon. hope that helps (?)
jeffullrich 651
Alumnus
Testing the Linus/Dirk spacing mystery.
And the second line. I hope this works.
Brendan 96
Glad you got it to work, Jeff!
The tip for Windows spacing, where you have to hold ALT then key in 0160, wasn't working for me at first. I found out you have to key the numbers by using the number pad. If you use the numbers at the top of the keyboard, it won't work. My laptop doesn't have a dedicated number pad, so I also have to hold the FN key to use the fake num pad, but it works.
I also found that "ALT" plus "255" works too (one less keystroke!).
GuruOne 6
Location: Down Unda
testing: backquote backquote
(testing is fun.... LOL)
edit: YEP.... easier to simply type 2 backquotes for line break
Bucho 187
Women sense my power
Location: The Future, aka Auckland, New Zealand
The problem with this round wasn't the judges, it wasn't any imaginary conspiracy and it wasn't the conceit of the Round 9 challenge, it was the wishy-washy criteria. Like Scott said earlier in the thread, it would have been better if the judges had been clearer on what was required. I've already said I agree with the decision, but what makes the show FUN isn't just getting the right decision, it's hearing the judges have a coherent discussion - and launching that discussion requires a solid foundation of clear and simple criteria. Everyone needs to start out on the same playing field - all three judges and every contestant - or the judges sound lost, and that makes the audience feel lost. And by Week 9 of this thing we listeners have learned how to judge a podcast that makes us feel lost.
Enough thrashing from me though - right now I want to throw a couple of definite positives at this thread. The "soften the listeners in preparation for elimination revelation" discussion regarding what success in podcasting means was great. Dave's point that a smaller but more rabid audience may be more desirable than a larger, less passionate one was a great observation from the standpoints of both artistic satisfaction and financial reward. The love from a more passionate audience is good for a mofo's soul and the fact a more passionate audience is more likely to shell out for merch and donations is good for a mofo's wallet.
Another thing was Belknap responding to Dave saying he felt bad after the elimination with: "That's because you're a good person inside but I'm drunk with power, I just want more things to eliminate right now." Or words to that effect. I cracked up harder at that than anything else in Round 9.
And I want to throw another salute at LHR for the hilarious and top-class way in which they received the news of their exit. You guys and gals are the champions of my heart as far as the Challenge is concerned.
Lastly, @JEFF: "Last night a bunch of us were talking about this very thing at UCB (Kumail, Aziz, Maron, Thune, Benson)." That's some weapons-grade name-dropping right there Chief. Nice work. Way to make a mofo envious.
ONWARDS AND UPWARDS GODDAMMIT!!!
dave anthony 0
Well, you guys are fun!
First off, I want to clear something up. I was on a comedy podcast, whether I was judging, hosting or part of the contest, that means I'm going to try to say funny things. Calling a submission "bullshit" and immediately following it up with "...that is what we are supposed to say here, right?" is a joke and it's my sense of humor. A lot of you guys don't know me but I don't plan on changing my humor because audience members don't know me.
Second, I voted based on laughs per minute and nothing else. I'm sorry many of you feel TL was less funny than LHR. I disagree. My opinion was only based on the five minutes I heard. I did NOT take into account my belief that LHR should have brought up Zach dropping out. That's my own personal opinion and I still believe it to be true but I voted based simply on who made me laugh in the end. Some of you refuse to believe TL could have been funnier than LHR. You're wrong. It was.
Third, a lot has been made about the instructions to the judges. Some things may have been left out but I am responsible for not hearing the submissions could be "under" five minutes and that the material could be anything. I was told but didn't listen. That's how I work. Maybe it would be better to write it down for the judges because some of us are dumbs.
Fourth, I think Scott and Jeff are doing something interesting here. They just created a podcast that is unlike any podcast in the world. I've never heard of a podcast contest like this and, in my opinion, it's good. And guess what? When people are figuring things out there are going to be bumps and stumbles. Mistakes are going to be made and there will be learning moments. I find the way some of you are treating guys who are trying to create a broad schedule of podcasts to be pretty disgusting. There is no conspiracy. There is no bias for or against. Sometimes things we like get kicked in the ass. That's life. Some of you need to take a step back and think about some things because life is full of injustices but most importantly, COMEDY IS SUBJECTIVE.
Fifth, and most importantly, your attacks here will make judges hesitant to be honest on any future Earwolf Challenges. "Hey, when you go do the Earwolf Challenge, be super nice to all the podcasts, no matter what you think because the listeners who disagree with you will go leave bad reviews on iTunes and attack you endlessly on the forum." Brilliant fucking move, guys. And, yes, more than one comedian has asked me about it today. You guys can scream all you want about how this wasn't done right but that can all be fixed next time around. Your actions cannot.
SetYourGoals 0
What's a podcast?
denzquix 8
I don't know, what's-a podcast with you?
truthskull 109
Dave, I totally agree with that entire post. Most of all though, comedy is subjective. I really hope this doesn't turn you away from Earwolf and its fans, the people who have shown themselves to be particularly shitty are very few compared to the real earwolf fanbase, and hopefully more of those voices will speak up. The internet can suck sometimes
EvilBunnySanta 1
To re-enforce what Martin Teller was saying, i have been fucking loving this show and am loving the drama and the judges takes, advice, and general outlook, whether its miss guided or not. That's why you have "guest" judges and not stuck with a judge you hate through the whole thing. And if this show doesn't get a second season because of a few negative nancies imma be pissed and will find where they live and give them a stern talking to.
Goddammit Dave, now you made those of us who defended you for not receiving a proper briefing look like fools. And I, for one, don't need any of your God damned help to look like a God damned fool!
Ah, who am I kidding, I can't stay mad at you.
Go To Topic Listing The Earwolf Challenge
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What is your favorite rap album?
Go to page Previous 1, 2, 3, 4 Next
Forum Index » Off-Topic » The Tavern
LordStenhammar
Location: The 9th Circle of Hollola
Posted: Fri Mar 08, 2013 10:27 am
Body Count is great. I have the censored version of Cop Killer -album. Very catchy and humorous.
godsonsafari
Location: Sparty's Land Grant University, USA
Posted: Fri Mar 08, 2013 12:17 pm
If you're into the screwtapes jute, you should listen to basically everything from OG Ron C, ESPECIALLY the Fuck Action mixtape series.
"It's not some safe thing like Fugazi where everyone sits down and eats their tofu and goes 'wow man, that's revolutionary' " - Jerry A of Poison Idea
Thumbman
The Shellfish
I don't have a favourite rap album, but I'll talk about a few I really enjoy. Although obvious, Nas's Illmatic is incredible. Great flow, great lyrics and an awesome beat selection. It is here that he feels his most real. He went for a more mainstream direction on the subsequent albums, but this one is 100% genuine. Perhaps it is the greatest rap record of all time. I've really been digging The Left's Gasmask lately. Awesome beats inspired by old music (horns make a frequent appearance), great flow and to top it off it even has a nice sample from Nas's Illmatic. I also quite like Sabac Red's Sabacolypse - A Change Gon' Come. It features a diverse beat selection, lyrics that are both political and about the streets and some great guest spots. Immortal Technique was by far my favourite rapper for a year or two, but lately I've started to get sick of the ever-present politics and the occasional conspiracy theories. I still think he's good, but his lyrics really need diversity. I wish he'd do more storytelling tracks - "Dance with the Devil" and "You Never Know" are incredible and very emotionally potent. If he really wants to get his message across, he should probably have some songs not about politics so he doesn't appear to be shoving his message down people's throats and also stop with the illuminati/free masonry conspiracy stuff because I think it kind of makes people take him less seriously.
In general I've been getting kind of sick of rap lately. Usually the programmed drums are awful and a dude rapping over a beat that never changes for four minutes can get a tad tedious after a while. I also feel that for a lyric driven genre, the lyrics are repetitive and, well, usually suck. I'm sick of it either being about "criminal in the hood with drugs and guns" or "criminal in the club with bitches and Patrone". It's done to death and boring. I don't care about how many drugs you used to sell, I don't care about how much money and girls you get and how you're the greatest rapper ever, just like every other rapper to ever exist apparently. I do feel like the producer Clams Casino is doing something interesting with his beats, with his shoegazey, ambient free floating "cloud beats". It's too bad he's wasting them on shit rappers like Lil B and Soulja Boy.
godsonsafari wrote:
Thanks for the suggestion. I'll check that series out.
shouvince
I'd listen to some rap occassionaly but it's difficult to pin point an album as such. I enjoy 'The Low End Theory' by A Tribe Called Quest. The somber vibes with those shoddy (ha!) basslines (beats) are alluring in a cool way. Legendary group.
Some have already mentioned Ice Cube. I have his Greatest Hits (2001) album and I dig that a lot.
These are the two memorable albums for me. The rest are singles scattered across different artists.
DeathcoreDecimator
Lil B is definitely hipster as fuck, but I don't care. I respect what he's doing. He's one of the only rappers I know of that preaches positivity, doesn't write shit, and has fire ass beats all while consistently dropping mixtapes on a REGULAR basis. Dude's got way too many songs. Sure his shit is way dumbed down, but I find it to be good philosophizing music. I like playing his mixtapes and just deciphering the nonsense that he has to say. The dude's mind is very intriguing. "Regular" rap got boring as fuck to me except for people like Danny Brown and OJ Da Juiceman. I've also been getting into a bit of Homeboy Sandman, but usually super lyrical rappers are just as dull to me as Lil Wayne, Rick Ross, Meek Mill, French Montana, Nikki Minaj, etc. etc.
dmforever1
see before i became a metalhead i was a bit of a rap fan my favorite album im gonna go with the classic and say dr dre's the chronic
hahaha I like Lil B for the same reasons DeathcoreDecimator does. And we both like OJ Da Juiceman. I don't think that's incidental. Neither are great rappers, but the beats man, THE BEATS. Part of me wishes metal bands would do something like mixtapes - drop a CD worth of free cover songs like every 9-12 weeks with a couple originals or throwaways and then get people geeked up for a full length record. Will never happen, but fun to dream sometimes.
It's weird, I love rap beats but I hate all EDM. It's probably due to where I was raised I guess. Either way, trap beats are the best thing to happen to rap since Tupac. Mixtapes are only possible because of the simplicity behind recording rap. It's insane how easy it is to become a rapper. Becoming a good rapper or at least a rapper that's refreshing and innovative is a different story.
What else I like about Lil B is he's essentially a genre of rap in himself with multiple sub-genres. It might be difficult to look at it like that, but if you've listened to enough of his mixtapes you begin to notice all of the certain styles he has. But it is really hard music to get into and it's easy to say "I'm not listening to this stupid swag bullshit" when in reality it has a lot more depth.
TheMizwaOfMuzzyTah
Location: the emerald forest
Damn if the first two Jeru albums don't come close to being favorites.
rawsewage
Location: Shamokin, PA
Just-Ice-Kool and Deadly
Kool G Rap-Live and let Die
Onyx-bacdafukup
Thats about all my brother could get me to like.
Erotetic
RapeTheDead wrote:
Him and related artists (Necro, Non Phixion etc) are absolutely worth checking out for anyone here with any remote taste in hip-hop.
excluding all of Necro's later material...
В Ожидании Смерти
DeathcoreDecimator wrote:
he's the only one doing his own thing in the rap game and I respect that beyond belief.
how do you even find the time to listen to everything everyone in the rap game is doing? I can't even keep up with the few artists I like, never mind all the ones I've never heard.
True, you're right. Let me reform my statement. He's the only one I know of and that is entertaining enough to me that's doing his own thing in the rap game. I do, or at least did a few years ago, listen to a LOT of rap. Does that work for you my guy?
HellishHound
Out of all the underground rap stuff I've listened to I have a couple favorites like:
Deltron 3030 - Deltron 3030
Dan the Automator is an amazing producer and I love all his projects. The zany sci-fi lyrics on this album are right up my alley. I'm into all kinds of zany horror/sci-fi/comedy the weirder the better and the lyrics really fit that bill, maybe not as much as my next entry though.
Dr. Octagon - Dr. Octagonecologyst
Again Dan the Automator is an impeccable producers and creates the perfect atmosphere for this album. Kool Keith came up with possibly one my favorite characters of all time with his Dr.Octagon person on this album. His lyrics match perfectly with that zany b-movie atmosphere I was talking about earlier.
Eyedea & Abilities - All albums
Abilities is pretty good producer but Michael Larsen aka Eyedeas's lyrics is what shine here, pure emotion and poetry.
Sage Francis - pretty much anything
Great, intelligent lyricist, good use better producers and better beats though.
I'll post again if I can think of more I used to listen to quite a few of those "underground/intelligent hip-hop artists"
iamntbatman wrote:
As a mature adult with refined tastes, I'm now smart enough to know that riffs are god, metal rules and hail satan.
ObservationSlave
HellishHound wrote:
Intelligent lyricist?
Like "when I came out my mama I was zero"...?
Ofcourse not every rhyme he writes is amazingly deep but the guy does have some very intelligent lyrics that work on a poetical level. Ofcourse all of this is my opinion
ChurningtheMaelstrom
Posted: Sun Mar 10, 2013 2:44 am
My favorite would have to be a tie between Beastie Boys' "Licensed to Ill" and Wu-Tang Clan's "Enter the Wu...36 Chambers".
I love the Beastie's album for its samples and high-school--ish lyrical content, especially since I was in middle school when I first heard it. My brothers used to play it non-stop on my one brother's ridiculous sound system that would shake the whole house. My best friend and I would get very high and play that album all the time, it was like the soundtrack to a few years of my life, some of the greatest I've had.
The Wu-Tang album was also heard by me around the same time, and I liked it's basic, gritty sound...production was average and it relied mostly on the talent of the members to make a soundscape, which, if you've ever been to a ghetto in NYC (like I have), is very palpable. It just sounded like a direct view into a world of grit, despair, and hardship. Hard to put into words how important this album is.
"Now I see this clearly. My whole life is pointed in one direction. There never has been a choice for me."
Necroticism174
Kite String Popper
I wouldn't go so far as to say I have favourite albums, as it's not a genre I have lots of expertise in, but favourites include Big L, Public Enemy, Tech N9ne, Immortal Technique, Tupac, Wu-Tang, Jedi Mind Tricks,Ill Bill, Non-Phixion,DMX, and Diabolic. Just off the top of my head.
theposaga about a Moonblood rehearsal wrote:
So good. Makes me want to break up with my girlfriend, quit my job and never move out of my parents house. Just totally destroy my life for Satan.
http://halberddoom.bandcamp.com/releases
Posted: Sun Mar 10, 2013 10:09 am
ObservationSlave wrote:
/snort
Yeah I'm not sure about that either. I used to listen to Sage Francis but never cited him in my earlier post. Some of his rhymes are good but at times he comes off as terribly pretentious.
Damn, didn't expect to get that much flak for someone I don't even listen to anymore haha I mean I agree with you guys so no need to snort at me, he does come off as pretentious ass (but to be fair snorting makes you seem like that too lol) and yeah not all of his lyrics are great. But some were pretty awesome.
I think you are looking at an innocent "snort" to be something which is far more than what it is. Don't play the victim man. It wasn't meant to offend you, but it was a mere response to that particular lyric which the other guy posted. Geez. Did you even read what I wrote after that?
Hey man I was joking too, hence the lol seriously man I gotta stop this now I don't want it to blow out of proportion. I wasn't actually playing the victim and I wasn't upset by what you said I knew it was innocent I thought you would realize I was joking too, sorry man.
Heh. It's ok. Just was reiterating that I didn't mind some Sage Francis at times
Think I'll listen to some outrageously popular 90s hiphop. Naughty by Nature seems like it will suit this time of day.
Cool man, haha I gotta be more careful I don't wanna make enemies While I'm still a "metal newbie" lol. And Looking back I could have been more clear about it so that's completely my bad.
Anyway, if you guys haven't heard of it I'd recommend checking out T/E/L/E/X by Auburn. It's a collab group between Eliot Lipp and Vyle. The lyrics are so/so he tries to be post-modern in this stream of consciousness thing that ends up just being him spewing nonsense and name dropping fashion houses. The beats are the best thing about this album and are very different.
corpsewithoutsoul
Pharcyde's 'Labcabincalifornia'. If you haven't heard this, give it a listen.
Hellrisen
Location: thE ocEAN
Wu Tang Clan - Enter the 36 Chambers. A completely essential rap album, a true classic in the rap game if there ever was one. Pretty much every damn song on this is killer. Even the skits on it are at least funny. All the rappers on it are on point. Indispensible.
Gravediggaz - Niggamortis/6 Feet Deep. I guess this is considered "horrorcore". Really good stuff though, the production is tops and there are some really weird raps on here. Features the RZA.
Bone Thugs-N-Harmony - E.1999 Eternal. A midwest rap classic. Pretty original stuff here, really dig the intricate wordplay and the mixture of rap and R&B style singing in the music. Nothing else they did was ever as good as this though.
Das EFX - Dead Serious. Really good old school stuff. Probably the only Das Efx album you need to hear. Another album where every one of the songs on it is a banger. More really intricate wordplay with this group here.
Redman - Whut? Thee Album. Just another good album and one of my favorites.
Scarface - Mr. Scarface is Back. Favorite Scarface album. A good start for southern rap I'd say.
You've got crabs, Ass-Face!
After reconsideration, I gotta give my vote to Jeru the Damaja's The Sun Rises in the East
PhilosophicalFrog
The Hypercube
DAS EFX - SHIT IS TIGGITY-TIGHT.
hats prices are at an all time low
║\
║▒\
║▒▒\
║░▒║
║░▒║with this blade
║░▒║i cut those who
║░▒║disrespect
║░▒║Carly Rae Jepsen
▓▓▓▓
[█▓]
To the people who suggested Aesop Rock, thank you. I listened to his last one and holy shit. I'll re-listen sober because I was hit over the head with incredibly dope flow, sweet and inventive beats, but most of all rhymes and wordplay so advanced that I literally had no idea what he was talking about most of the time.
http://www.youtube.com/watch?v=aRiS0lELg3o
listen to that you stupid faggot.
Tod_Im_Juni
Dr. Dre - 2001 Although I dislike rap, I would listen to this album quite a lot.
kapala
Wu-Tang's 36 Chambers and Forever are classics. Those two will always be two of my favourite albums, of any genre. Raekwon's Only Built for Cuban Linx is another, as well as RZA's Birth of a Prince.
Some other favourites are Supertight and Ridin' Dirty by UGK, old E-40 like Federal and In a Major Way, The Diary & In a Major Way by Scarface.
I'm probably forgetting a few essentials, but these are definitely the albums that get played the most.
*edit* I knew I'd forget something. Above the Law "Black Mafia Life". Completely underrated. One of the better "g-funk" era albums.
MariusBR wrote:
Go ask a Swede by the way. [...] They would probably tell you that the only way to be BM is to wear a mace in your pants.
Porman
Sweek Souvlaki Muncher
Only one album? It's not hard for me to pick out the single most important vinyl in my collection.
Check Your Head by the Beastie Boys.
I hassled the staff over at the local record store for 2-3 weeks, daily, ever since I got Pass the Mic on American import earlier in April.
That album got played twice. Once when I listened to it for the first time, then when I dubbed it on to a tape. That tape in turn, I listened to daily up until Ill Communication was released two years later.
Except for every other album by the Beastie Boys I really enjoyed these:
N.W.A. - Niggaz4Life
Digital Underground - Sons of the p
2 Live Crew - Live in Concert
Geto Boys - Uncut Dope
The Goats - Tricks of the Shade
Biz Markie - The Biz Never Sleeps
Stetsasonic...
Ah, there's too many to mention!
http://www.youtube.com/watch?v=-MUxcVHctrQ
Tempered_Steel
MF DOOM- Operation Doomsday
Oblivion_Gene
Posted: Tue Mar 12, 2013 11:08 am
"Gravediggaz - Niggamortis"
^Haha, excellent.
Can't say I have a favorite rap album, but I dig a few artists like Tupac, Tech N9ne, Notorious BIG, Bone Thugz, old Eminem, Hopsin, DMX, etc... Kendrick Lamar is pretty cool. Generally not that far removed from the mainstream.
Hircine
Can I be boring and say "Straight Outta Compton"? Because it's that. To be honest though, I struggle to enjoy rap music in album length.
Life is your worst enemy.
Wolfgong wrote:
By the way I am straight and male and get a kick outta tricking chicks to get into their pussy
doomster999
Keeper of the Dreary Realm
Here's my favourite rap album
gomorro wrote:
Infact I use to have a relly hot friend from there but unfurtunetly the last party we have I was really wasted and grab her ass and it cause a huge problem. Her dad (that is a marine) wants to ripp my nuts... thinks are not the same...
norcalslayings
De La Soul-Stakes is High or any J Dilla album.
Any Roots album
"Grow-Room is church temple of the new stoner breed
Chants Loud-Robed priest down on to the freedom seed
Burnt offering redeems – completes smoked deliverance
Caravans’ stoned deliverance"-Sleep's Dopesmoker
LO FI GRIND- http://alaskanpipelinesgrinds.bandcamp.com/
darkeningday wrote:
Aesop Rock's Skelethon and Illogic's Celestial Clockwork are unlikely to leave my playlist for the next decade.
fuck yeah Aesop > All
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Codies Lounge
The Game Thread!
By Tylerrnty1, April 4, 2014 in Off-topic Discussion
sjsharp2010 200
Hughesy said:
One cool touch they have added, whilst going through the tunnel at Monaco if you get the engineer talking to you its all fuzzy :D I just like that attention to detail, but maybe that's just me.
yeah that's one thing I'm liking too the attention to detail they've given the game this time out. Especially the night races. .Sometimes I do play on a higher level (usually only when I've had a season where I've dominated though) but I thought I just wanted to win first time out and given CM's AI in the past, I wasn't sure what settings to pick so I normally in those situations start on the easiest settings and work from there as that's what I tend to do with most games.
Also it wasn't that easy to win as I didn't clinch it till the penultimate round in Brazil so the Mercs made me work for it. I may play at a higher setting later but I'll see how I do in the 2015 cars first. Was thinking those colourful blue and yellow Sauber's might be a nice challenge. Plus I'm racing for Sauber on 2010 atm so I'm tempted to have a go in those when I do it.
jordieDAFC 0
If you take away all the bugs its actually a great game. But unfortunately people seem to want to concentrate on the negatives, as with all the Codemasters games....
Their loss....
Hughesy 251
Ok so the backmarkers just totally ruin the race at Monaco. Rosberg was 14 seconds ahead of me, but once he caught backmarkers I caught up with him within a few laps..... That's the one thing they need to change in regards to the AI, as at the moment they don't slow down or move out the way, they just race you.
Yeah I had a few troubles with backmarkers too in my season. Ericsson in the Caterham was particularly bad
Ok it's totally messed up, the backmarkers aren't even being given blue flags....... This must be a bug. This is going to be a long 78 laps :|
One of the many pleasures of racing at Monaco I suppose. Just received my dispatch note for the PGA game I ordered from Shopto.
sjsharp2010 said:
Yea but the issue is a bug. After testing, the only place they get blue flags is the last sector, then sometimes they try moving out the way by slamming violently into the wall. Along the rest of the lap like the main straight they aren't given blue flags, so they don't move out the way. I do 100% race distance so this is very tiresome, might just retire even though I'm second, as I can't be arsed....
yeah can't say it happened to me as I had a bad race there in my 2014 season on the game but then I don't tend to go well there anyway. I've only ever won at Monaco twice on CM's games and on both those occasions was on 2012 not on 2015
Never played the previous Sniper Ghost Warrior (only Sniper Elite) but GW3 sounds awesome, and the graphics are stunning. Need to see more but it does look great. http://www.guru3d.com/news-story/sniper-ghost-warrior-3-screenshots.html
RevolvingPrawn 1
It's being made by the same studio as the first 2 so unfortunately it's likely to suck. The first was one of the worst games I've ever had the misery of playing, the second was an improvement but not by much. Finished the story on it but when it got to the end 6 hours in I was like "What? Really? That was the ending..."
So yea try not to hold your breath dude :p
RevolvingPrawn said:
Yea that's why I didn't buy the first two, but you never know it could be good. I'll obviously wait for reviews, and then make a decision.
I hate it when games atart being a pain in the neck and stop working. Trying to get one of my old classic adventuer games to work and it's not playing ball atm.
Uh yea.... 66th lap at Monaco and I now have a invisible car in front of me, I don't know weather to laugh or cry :joy: All I can see is its shadow..... I drew a red ring around it so you can see it.
Got it working eventually took me pretty much all day to do but I'm happy
I know I'll get hate from @Lukedfrt for this, but I'm not sure what's so exciting about Shenmue 3, I mean it looks like a PS2 game. Seen clips from previous games with a corny story, and terrible voice acting...
http://youtu.be/gY6GzhjPXaE
Gotta agree :p It looks like the kind of game you'd see on a 10 year old arcade machine. I was half expecting those bugs to turn into giant alien bugs which you then have to pick up a light gun and shoot ;)
Lukedfrt 91
Shenmue is my favourite game of all time! There was nothing like it when it came out, the detail in the world was amazing, and the graphics were the best!
I'm not sure how Shenmue 3 will turn out, hopefully it's attention to detail is as impressive as the first... but at least after 15 years i can finally finish the story! :p
Lukedfrt said:
Going by that video I posted it isn't going to be highly detailed and the graphics are going to be like a PS2 game :joy:
That's kind of how I feel about the Longest Journey/Dreamfall series it doesn't have the finest graphics by todays standards but I thought it was beautiful when I first saw it it's a fine point & click adventure As they're working on the third game now they've got 3 parts of it done just books 4 &5 to come. Haven't had a chance to play through Books 1-3 yet but I'm working my way through the first 2 games to remind myself where the story was for when the third game starts so I can then get cracking on third game when I'm done.
Yeah, it's very very early footage though, it's at least 2 years away... So hopefully it will improve a lot graphically.
Also... The Kickstarter is very nearly at 5 million :#
Damn... If I'd know there was the potential to earn that much on a game like this... I could have put up a kickstarter for it myself, spent 2 years learning how make a game with PS2 graphics for about £5, and kept £4,999,995 for myself ;)
But Project Cars looked as awesome as it does now from the first build, so I don't buy that excuse :p
Platy 6
But Project Cars spent all their time making it look good and forgot to make it work properly.
Mexicola 9
That and a lack of PS4 have stopped me from touching that game.
@RevolvingPrawn Oh dear, this isn't good... :|
http://www.pcgamer.com/batman-arkham-knight-wont-be-finished-this-season-according-to-source/
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Philip Rivers: Scoring key, not playing keep-away from Peyton Manning
Thread: Philip Rivers: Scoring key, not playing keep-away from Peyton Manning
JesseH
In the San Diego Chargers’ only win in three games against the Denver Broncos last season, the blueprint appeared pretty clear.
The Chargers used running back Ryan Mathews to wear down Denver’s defense by churning first downs. San Diego’s defense won on third down against one of the best quarterbacks ever to play the game.
And by churning first downs on offense, quarterback Philip Rivers essentially played keep-away from Manning.
Mathews ran for 127 yards on 29 carries and a touchdown. The Chargers held the ball for more than 38 minutes. And Denver’s offense finished 2-of-9 on third down, helping San Diego earn a 27-20 victory.
Can San Diego put on a repeat performance on Thursday night?
“We want to be on the field as much as we can,” Chargers offensive coordinator Frank Reich said. “We want to play our game. And that is our game. Our game is convert on third down, mix it with the run and pass, be efficient and score touchdowns in the red zone.”
Reich went on to say that undrafted rookie free-agent running back Branden Oliver will get his opportunities on Thursday. Oliver has rushed for over 100 yards in two of San Diego’s past three games.
“Against this defense you want to stay out of third-and-longs against those pass-rushers that they’ve got over there,” Reich said. “So we want to have positive plays, stay in phase and try to keep doing what we want to do. And Branden has been running the ball great, so we’re going to try to get him more touches than he had last week.”
Oliver rushed 16 times for 69 yards in a loss against Kansas City last week.
Rivers said whether or not his team runs the ball effectively or controls the clock, there’s one thing the Chargers have to do -- score early and often. Denver is averaging a league-best 31.5 points per game.
“I don’t think we go into the game playing keep-away,” Rivers said. “We go into the game playing to score. And if we score fast, great -- but we’ve got to score. You can’t go three to four possessions without scoring. We did that in the playoff game, and when you look up it was 21-0, 17-0 or whatever it was, just like that. And that’s not a team you want to be playing catch-up with all day long.”
kingelway7
Is Rivers aware that our Defense is 10x better this year than last year? Not saying that Rivers wont have a great game, but he shouldnt think itll be just as easy to put point up against us tonight as it was last years Thursday night game.
the0rangecrush
Rivers solution to winning the game: Score more points than them. Good job Phyllis I'll put a gold star next to your name
baphamet
Originally Posted by the0rangecrush
the smack forum is that way ------------------------------------------->
i think the quote from rivers was spot on, however they didn't get it done.
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Articles & Current Affairs
The War Room: "Rape Those Who Insult White Sharia!"
Page 8 of 8 First ... 345678
Thread: The War Room: "Rape Those Who Insult White Sharia!"
Thursday, September 14th, 2017 #71
Nordic Angel
Nordid + Dalofaelid
Married parent
Germanic Nationalism
Originally Posted by Ocko
I don't know why you focus so much on rape, it seems to be a big point in your fear system.
I can't believe what I a reading here. Rape traumatizes and destroys the life of a woman forever, so OF COURSE women are afraid of it.
Another aspect is that many women have 'rape fantasies' to arouse themselves. That is a known fact.
This is not a known fact, it is bullshit. There may be women who fantasize about submitting to the man during sex and him being the leader, but that has nothing to do with rape. Rape is violent and forced sex against the will of a person. And when someone is aroused by something and wants it, then it is not rape.
After all it is a crime and dishonorable for a man to engage in it.
Well, at least we can 100% agree on that.
I also agree with what was said about vigilante justice here. If anyone ever tried to rape me or - God forbid - my daughters, there would not be a single thing in the world that I would consider too cruel to do to him/them.
The Following User Says Thank You to Nordic Angel For This Useful Post:
Rodskarl Dubhgall
Eala Freia Fresena
"Friend of Germanics"
Skadi Funding Member
Monday, July 29th, 2019 @ 12:24 PM
Nordid
selfemployed
none/pagan
Originally Posted by Juthunge
Yes, the local peaceful ISIS and the hundreds of other Islamist groups who basically merely adhere to the literary sense of the Quran, are clearly much better.
You obviously do not know the Koran. It's a willful statement from an ignorant.
No idea where you got that from in the first place but since when is “nearly White” the yardstick to measure Germanics on?
Even if they were "nearly White", it would have happened by White Slavery and Harem rape.
Why would 'nearly white Egyptians' be the yardstick for Germanics? It's a weird answer unprovoked by what I said.
I’m sure some group of people planned their wars a hundred years beforehand and wrote a book about it in the late 19th century. Yes, of course.
That the race-who-are-not-allowed-to-be-mentioned plans through centuries isn't anything new. If you read the 'protocols' you have actually proof of it. The current invasion of blacks and Arabs have been planned by Coudenhave-Kalergi almost a century ago. Merkel was awarded the Coudenhave-Kalergi prize as a chancellor. Coudenhave-Kalergi belongs to race-whose-name-is-not-allowed-to-mention. I don't know why you don't know what everybody else knows.
It may be a fact or not but it’s certainly a fact that the opinion of eastern women is irrelevant to us. They aren’t us and we never had the same values as Slavs. Being traditional means some very different things in different cultures.
Why would only eastern women appreciate traditional roles but Germanic women are different and thus can't do the same? You argue against yourself. Unless you can provide the difference between traditional Russian feminine roles to Germanic traditional feminine roles. So what's the big difference?
That’s the practical Islam that’s actually relevant in the real world. Whether it’s a “good idea” on paper – which is already quite doubtful - is irrelevant because so are some aspects of Communism. But that doesn’t mean any of either would ever work or is a good idea. For us, at least.
Practically if you go to a prison, asked who is baptized and then make your judgement about Christianith on that base it will have serious flaws. The people which Merkel invites to Europe is just scum which claims to be Muslim. To explain why they are scum would break Skadi Sharia.
If the concept to which you are referring to by the term “White Sharia” has nothing to do with actual (Islamic) Sharia then why refer to it by that idiotic term in the first place? You have to decide for either.
How are we otherwise supposed to know what you talk about if you use existing terms and use them your own ideas? Debate becomes pointless in that case.
If the debate is pointless, then why are you debating it? The name provides anger, surprise and whatever it gets attention. In the name inbound is a strictness and the imagination that degenerate women will be controlled. That would have been normal in western countries up to the sixties of the last century. It isn't really foreign to western people. Beside that in western countries women watched very closely over women's honor themselves. Harsh treatments against women who cheated came from women themselves. If you are against white Sharia you are against your own tradition. (I don't know who you are, you might have a different tradition in mind, based on suggestion by the race-whose-name-are-not-allowed-to-mention)
Modern Egyptians are a more Sub-Saharan influenced than their ancient counterparts, it's true, but that doesn't mean that the latter were White. They were as "White" as modern Palaestinians and Bedouins.
Who, as well as other modern Levantines, are very close to their ancient counterparts from the Neolithic onwards and far removed from Europeans:
Tut anch Amun had Celtic/Irish DNA. So I assume you are ignorant to the race of ancient Egyptian.
That’s a non-argument. To impose “White Sharia” you’d need to be in a place of power anyway, as much as for any other ideology. So why not actually use some other ideology that actually fits us?
I think anyone can apply rules in ones own life, most women here most likely practice 'white Sharia' here themselves as they most likely act honorable according to Germanic traditions.
I am interested to hear about the ideology you mentioned to bring Germanic maniac degenerate women to a life which is uplifting. Any suggestion would be interesting.
It’s entirely irrelevant whether it's Blacks, “White” Russians or their Asiatic hordes who raped German women.
I leave the answer to the women here.
There’s nothing to debate there anyway. Russian influence in Germanics is non-existant and the Germanic influence in Russians is almost zero and restricted to very narrow geographic regions.
If Russians see that differently, that’s their problem but it’s not based on facts. So stop trying to excuse yourself being an ethnic mixer and traitor to our people by claiming that Russians are “oh-so-traditional-White/Germanic/Aryan”.
Genetically White Russians are very close to Germanics, migration movements have been plenty. There is another thread here which argues that the real Vikings came from Russian territory, basically the ancestors of White Russians. As the Vikings are considered by many as the epitome of Germanic maleness it is pretty ironic what you claim. Their leader was supposedly a Uldin, which later transformed into Odin, the head God of the Germanic 'religion'. I can hear you already saying that Russian Vikings are irrelevant to Germanic people and Odin should stay out of Germany. Plus all the heathenism based on the Edda is foreign.
There are still Russian conclaves in Germany, like the Sorben, and as well a lot of settlements from Germanics in Russia. Their Czars married Germanic princesses and the Czars became over time pretty Germanic.
Russian composers are pretty close in their productions to Germanic ones. The interest of Russians in Germanics is still strong and visa versa too.
As it is said: 'Ignorance is bliss'. I hope you stay blissfuly
weel nich will dieken dej mot wieken
Originally Posted by Nordic Angel
Here is a study out of a ton of articles. It's in Psychlogy Today, a pretty reputable journal as far as I know
https://www.psychologytoday.com/blog...rape-fantasies
There are fantasies and reality. For legal reasons let's keep it in the fantasy area
Friday, September 15th, 2017 #74
]You obviously do not know the Koran. It's a willful statement from an ignorant.
Yes, I profess freely that I probably haven’t studied the Koran as closely as you did. Quite frankly because I prefer to spend my time studying our own heritage of a few thousand years and not to look for remote traces of it in the least likely places. But nothing I read in and about the Koran leads me to retract any of my statements.
Then please enlighten me as to how that passage of yours was in any other way relevant.
Coudenhove-Calergi was the son of a very pan-European-mixed, but non-Jewish, Austrian aristocrat and a Japanese. Born in 1894, whereas the so-called Protocols were already published in 1903. So unless he wrote them at the age of 9, why did you bring him up?
If the debate is pointless, then why are you debating it?
Because before I had no idea that I’m fighting windmills and sandcastles in the sky.
If two people are trying to discuss something they call by the same term but it actually mean something entirely else for one party than the commonly accepted definition of the term, they’re constantly talking past each other. That’s obvious from the following:
The name provides anger, surprise and whatever it gets attention. In the name inbound is a strictness and the imagination that degenerate women will be controlled. That would have been normal in western countries up to the sixties of the last century. It isn't really foreign to western people. Beside that in western countries women watched very closely over women's honor themselves. Harsh treatments against women who cheated came from women themselves. If you are against white Sharia you are against your own tradition.
Some of your ideas about White Sharia are neither those of the original coiners of the term, nor how other people, least of all, women, understand it.
If you’re speaking about Germanic tradition, then why not bloody call it that instead of White Sharia?
That’s why this is going to be my last reply to you because I’d rather prefer not to waste my time about something which is not even halfway clearly defined.
(I don't know who you are, you might have a different tradition in mind, based on suggestion by the race-whose-name-are-not-allowed-to-mention)
I’m showing you a PCA from an actual recent genetic study on the matter, which shows that ancient Egyptians, from all social classes, from different time epochs cluster among modern Levantines and your reply is this? Honestly?
I suppose your referring to the claim by “IGENEA”, the same company that claimed Germans are basically not genetically Germanic at all but 10% Jewish, 5% Phoenician, that Tutanchamun was of the Y-Haplogroup R1b-M269. Which in itself originated 12.000 years ago. Some, very recent, subclades of it are Celtic/Irish but certainly not the haplogroup as a whole.
But well, turns out, like any other ridiculous theory by this company, it’s entirely unfounded:
If the claims were true, it would put King Tut in a genetic profile group shared by more than half of Western European men. That would make those men relatives — albeit distant ones — of the pharaoh.
But Carsten Pusch, a geneticist at Germany's University of Tubingen who was part of the team that unraveled Tut's DNA from samples taken from his mummy and mummies of his family members, said that iGENEA's claims are "simply impossible." Pusch and his colleagues published part of their results, though not the Y-chromosome DNA, in the Journal of the American Medical Association (JAMA) in 2010.
Are you getting your information on genetics from the Daily Mail or the Bild or something?
By having Germanic men that behave as such, show them the way when they’re objectively wrong(firstly by leading by example) but don’t fantasise about raping them into submission and other such nonsense.
Clearly my mother and my sister, for example, came out right and so will my niece, even without White Sharia. That’s because they have proper Germanic fathers and mothers that educated and husbands that love them and were and are immersed in a Germanic tradition.
Yes, please ask our female members if they prefer to be raped by one of your Russians. I think I know the answer, looking at the opinions of our female members about you.
Genetically White Russians are very close to Germanics, migration movements have been plenty.
I understand that you have to make up your own pet theories to get the picture out of your head, that your German ancestors are turning in their graves because their descendant breeds with a member of the people that has down so much harm to us but here’s the truth:
Germanics form a very tight cluster, with Russians being far removed and drawn towards the Chuvash. The only slight overlap is between Eastern Germans and genetically partly germanised Poles and Czechs(not that it would make modern mixing with them any better).
There is another thread here which argues that the real Vikings came from Russian territory, basically the ancestors of White Russians.
As the Vikings are considered by many as the epitome of Germanic maleness it is pretty ironic what you claim. Their leader was supposedly a Uldin, which later transformed into Odin, the head God of the Germanic 'religion'. I can hear you already saying that Russian Vikings are irrelevant to Germanic people and Odin should stay out of Germany. Plus all the heathenism based on the Edda is foreign.
That’s not even what that article in the other thread claimed. It claimed, a part of the ancestors of the Vikings came from Central Asia.
Needless to say, that it’s entirely unsupported, too and even more ridiculous than your suggestion. That’s why we have peer-reviews in actual science, so as not to have to read the gibberish of random hobby geneticists that don’t actually know anything about the subject.
To give the original author of that article some credence, though, he published this already 10 years ago. And though it was already unsupported by the evidence back then, it’s more understandable that he theorized about it in light of the available genetic methods back then. It should simply not have been posted on here that late in the first place, though, as it’s entirely anachronistic.
But that people, who claim to be interested in the origins of our peoples, post such nonsense and others of “us”(not sure about that anymore) actually believe them, even though modern autosomal DNA is freely available for everyone for years, is beyond comprehension for me.
There are still Russian conclaves in Germany, like the Sorben, and as well a lot of settlements from Germanics in Russia.
Sorbs as Russians…I’m starting to doubt you have ever been German to begin with, judging from how little you know about Germany.
The Sorbs are primarily descendants of the local Slavs in Eastern Germany, partly mixed with Germans. There’s nothing “Russian” about them but even they are genetically not very close even to actual Eastern Germans:
Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity
Their Czars married Germanic princesses and the Czars became over time pretty Germanic.
The Romanov, who, in case you haven’t noticed in your universum of alternative world history, have been extinguished in 1917, being partly Germanic certainly made the millions of their Slavic subjects very Germanic, yes. I suppose by osmosis.
Russian composers are pretty close in their productions to Germanic ones.
So were French and other Romance composers. How is this a sign of genetic relatedness?
The interest of Russians in Germanics is still strong and visa versa too.
Yeah, so is that of and in the Chinese.
Thanks, you too. Tell me, if you ever visit the planet earth again.
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As you admit you don't know the Koran but have a lot of false judgements about it and want to enlighten me that Coudenhave Kalergi never wrote the protocols I take the rest of your claims with a few grains of Salt.
The haplogroups between Austrians and Englishmen are also quite different but both are counted as Germanics. I am not going to discuss now which is further apart the Austrian/English group or the German/Russian group.
Haplogroup are just that, Haplogroups.
If your Group haplos more with another or not is not the point I am talking about.
I am German because I was born and raised in a (damaged) Germany. My attitudes, thinking, value system, culture is distinctly different from other nations. Even in Germany there is a big difference between people, like Prussians/Bavarians, Frisians/Rhinelanders etc pp.
They are all bound together by non-physical things and by physical features what makes them compatible.
Nations are a meta-physical term for me and not a Haplogroup which doesn't say anything about a nation, just some genetic tiny thing in your body.
From that point of view Germans have an affinity to Russians and that is an old thing. German are known (or better have been known) as the people of poets and thinkers. And if you know Russian writers like Dostojewsky (who actually was against western influence) and compare them with German writers you find similarities in Character and spirit.
Your stupid Haplogroup cannot explain anything of it. You basically do not even know how a DNA shapes a persons body and not even whether it does.
There are plenty of tiny things in my body, like blood types which make me superficially different from other people. Do I have to love people now who have the same blood type, the same Haplogroup, or heartbeat?
I do love my own people, not their haplo nonsense.
Huginn ok Muninn
Anachronism "Friend of Germanics"
Germany, Norway, England
Nordeby
Single adult
Farther right than you.
Where do I begin with this? The Protocols of the Learned Elders of Zion was published in 1903, when Richard von Coudenhove-Kalergi was nine years old. Enough said about your assertion that he wrote the thing.
You claim that Coudenhove-Kalergi was a Jew. That is easily disproven, since his father was an Austro-Hungarian count and a diplomat, and his mother was Japanese. The Japanese part speaks for itself, and there is no evidence of Jewish background in his father's line.
As to your defense of Islam and the Koran, you do realize this is an alien work of an alien mind and has nothing whatsoever to do with Germanic culture? Whatever "tradition" this work enshrines is an ALIEN tradition. Far more alien than the Russian culture which you also venerate, but, though not nearly so alien, remains an Eastern Slavic culture, quite distinct from our own. (And by the way, the Sorbs are not Russians, they are Western Slavs, closely related to Czechs and Poles, and are mostly Germanized.)
Coudenhove-Kalergi was most certainly an enemy of all European ethnicities and cultures, because he wanted to blend them all together. Whatever arguments he makes for his case, I think the real reason he became entranced with this idea was because of his own confused background. The male offspring of European men and Asian women are very often mentally disturbed, and this character seems no different from any other such mongrel, except he was a member of a degenerating upper class which ascribed less importance to finding a mate from a similar culture, and more importance to whether or not that mate had lots of money. It's a mammon-worshiping cult, which gave them common ground with the Rothschilds and other Jews whose fortunes were built upon usury.
As to the "Protocols," they are obviously not a forgery, but were written by certain Jewish elites as a plan to conquer European societies from within. This document, written by someone in or before 1903, lays out a plan that has closely paralleled reality ever since. Anyone who asserts this is a forgery is either stupid or expects his listeners to be.
Most people think as they are trained to think, and most people make a majority.
Moderator "Friend of Germanics"
2 Weeks Ago @ 08:14 PM
Bavarii, Saxones, Suebi, Alamanni
Borreby + Atlantonordoid
Einöde in den Alpen
Tradition & Homeland
Odinist
This is the second topic we've had about the matter of 'White Sharia' in the course of a week or so. Both have spiralled down exactly the same route. Both have, alone and combined, received more complaints from members of all walks than all other threads on board combined in the past two months.
What Skadi Forum is: A safe haven for preservationist-minded Germanics of all walks happy to see our culture, spirituality, ethnicity and race preserved. A place to unlax, a place to discuss about matters pertinent to Germanics - ranging from knitting to martial arts to current affairs, high politics and physical anthropology. And, if people so please, indeed also a place to discuss the challenges and dangers ahead of our folk and be outspoken about threats thereto in any heated manner short of flinging slurs like a monkey.
However, what Skadi Forum is NOT: A place to downplay or promote sexual violence against women, a place to glorify Islam and/or its writ, a place trying to strip Germanics of the last bit of heritage by claiming they're not genuinely an own meta-ethnicity or anything related. We see enough of this bullshit IRL every day, we don't need it here. This isn't about Free Speech (which we support), this is about sucking it up to potentially the most immediate and indeed greatest demographic threat Germanics have seen since the Plague (which we condemn).
Thread is closed. And I don't want to see another thread on 'White Sharia' or otherwise mindlessly praising Islam, especially when attempting to weigh it favourably against our own heritage, any time soon. Any such attempts will be seen as going against Forum policy & Mission Statement and will be met with immediate closure and - if necessary - disciplinary action beyond that.
Like I said, we see enough of this bullshit IRL every day, we don't need it here.
-In kalte Schatten versunken... /Germaniens Volk erstarrt / Gefroren von Lügen / In denen die Welt verharrt-
-Die alte Seele trauernd und verlassen / Verblassend in einer erklärbaren Welt / Schwebend in einem Dunst der Wehmut / Ein Schrei der nur unmerklich gellt-
-Auch ich verspüre Demut / Vor dem alten Geiste der Ahnen / Wird es mir vergönnt sein / Gen Walhalla aufzufahren?-
(Heimdalls Wacht, In kalte Schatten versunken, stanzas 4-6)
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My War Room
By Gareth Lee Hunter in forum Self-Defense & the Art of War
Last Post: Wednesday, November 14th, 2018, 07:48 PM
Sharia Police in Austria: Muslims Threaten to Rape a Woman Bathing Topless Unless She Covers Up
By Nachtengel in forum The German Countries
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864.558.4569 (GLOW)
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Nicholas Hawkins (Morales and Doncario: Carmen / Dogette and Reporter: Best Little Whorehouse in Texas) is a native of Greenville, SC, and a graduate of Wade Hampton High School, and The Fine Arts Center. Nicholas, received his degree in vocal performance from the University of South Carolina in 2016, where he was a member of both the Concert and University Choirs. In addition to his choral participation, Nicholas performed several roles with Opera at USC such as in Don Giovanni(Il Commendatore), and in Hänsel und Gretel(Der Vater). Most recently, Nicholas was seen in Centre Stage’s productions of Dreamgirls(Tiny Joe/Wayne) and One Who Flew Over The Cuckoo’s Nest(Chief Bromden). This is Nicholas’ 3rd glorious season with Glow Lyric Theatre, and he is excited to work with a company that has provided him so many wonderful experiences, as it had with his participation in past productions such as Romeo et Juliette and Hair. Nicholas hopes that you all enjoy the show, and that the work that has been done touches you all in a profound way.
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Premier League: Free-for-all in top-four race as favourites falter and fumble
Sport Football
Chelsea flop again but Arsenal have most cause for concern
Published: December 16, 2019 14:13 Matthew Smith, Deputy Editor Sport
Arsenal were floored by Manchester City in the Premier League. Image Credit: AFP
Dubai: While high-flying Liverpool and Jurgen Klopp can turn their attentions to the Club World Cup in Doha, safe in the knowledge they now hold a 10-point lead at the top of the Premier League table, alarm bells continue to ring around so-called ‘Top Six’ sides back home in England.
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Seven points separate Chelsea in fourth and Arsenal in ninth, with Manchester United and the unlikely duo of Sheffield United and Wolves in the mix.
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While Ljungberg is not the answer, Arsenal are scratching their heads as to whom to appoint on a permanent basis to replace their caretaker.
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P W D L F A Pts
1 Liverpool 17 16 1 0 42 14 49
2 Leicester 17 12 3 2 40 11 39
3 Man City 17 11 2 4 47 19 35
4 Chelsea 17 9 2 6 31 25 29
5 Tottenham 17 7 5 5 32 24 26
6 Man Utd 17 6 7 4 26 20 25
7 Sheff Utd 17 6 7 4 21 16 25
8 Wolverhampton 17 5 9 3 24 21 24
9 Arsenal 17 5 7 5 24 27 22
10 Crystal Palace 16 6 4 6 14 18 22
11 Newcastle 17 6 4 7 17 24 22
12 Burnley 17 6 3 8 22 29 21
13 Brighton 16 5 4 7 20 24 19
14 Bournemouth 17 5 4 8 19 24 19
15 West Ham 17 5 4 8 19 28 19
16 Everton 17 5 3 9 20 29 18
17 Aston Villa 17 4 3 10 23 30 15
18 Southampton 17 4 3 10 18 36 15
19 Norwich 17 3 3 11 18 35 12
20 Watford 17 1 6 10 9 32 9
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Home » Gear Reviews » Running » Running Shoes » Trail Running Shoes » Cushioned & Protective Trail Running Shoes » Asics Gel-FujiRado
Asics Gel-FujiRado Review
Smooth lacing system
Inner bootie
Supportive upper
Durable outsole
Narrow midfoot
Rigid heel
Firm midsole
The new Asics Gel-FujiRado comes with substantial improvements to the fit and function of the previous model, including two distinctive upgrades: a stretchy inner bootie and a micro-adjustable BOA lacing system. Despite upgrades, the FujiRado’s performance is middle-of-the-road and it’s more of an all-around off-road shoe than a high performer in any single type of trail.
The new Gel-FujiRado (presumably named after a combination of “Mount Fuji” and “Colorado”) replaces the Gel-FujiAttack 5 as Asics’ flagship trail shoe. Many of its features and design choices are unsurprising for a multi-use trail shoe. It’s built on a neutral platform with 23mm/15mm stack height (8mm heel-to-toe drop) with 3mm multi-shaped lugs on the full-coverage outsole. Two features, however, make the FujiRado stand out from the field (and certainly from Asics’ uninspiring line of other shoes). One is the full-length inner bootie, which Asics calls a mono-sock. The other is the micro-adjust BOA tension lacing system, which Asics uses on the FujiRado in lieu of traditional shoelaces. Wear-testers praised both of these features, and felt like they elevated what could have been just another generic trail running shoe. Our test team expressed concerns, however, about the FujiRado’s narrow fit, rigid heel, and excessively firm midsole. Ultimately, despite some innovative and distinctive features, the FujiRado is held back by issues that may be deal-breakers for some runners. As one tester put it, “I love the way this shoe looks and I like Asics’ willingness to innovate, but out on the trail, it just doesn’t live up to my expectations.”
One wear-tester gave the FujiRado the ultimate compliment about comfort with a note that, “this may be the only trail shoe I’ve ever considered wearing sockless.” That’s thanks to the smooth, stretchy “mono-sock” inner bootie. With pull-tabs on the front and rear, it’s easy to stretch the bootie enough to slip in a foot. The mid-height front of the bootie gives the FujiRado a really distinctive shape, and our wear-testers didn’t report any extra rubbing or friction on the front of the ankle. The mono-sock is not a single piece, however, and there are a number of seams inside the uppers. None of our wear-testers experienced discomfort or blisters from them, although no one reported actually wearing the FujiRados sockless either.
The FujiRado’s firm midsole made it feel like a fast shoe on the trail and the flexible forefoot encouraged quick footstrike with efficient turnover. Asics uses a proprietary midsole material called SpEVA, which it claims is a lighter, more flexible version of traditional EVA foam. Some wear-testers felt that the midsole was too firm for a shoe of this weight (10.7 oz for men’s size 9), and in this category, because their legs took a pounding after 12-15 miles on the trail. The 3mm lugs were small enough that some wear-testers lost speed through wet and technical sections of trail, although the small size made the FujiRado feel quick on hardpack and fire roads. The lugs are C-shaped and oriented so that the outsole bites on both climbs and descents.
The FujiRado shines here. The mono-sock bootie cradles the foot, while an outer cage of more structured material wraps around the instep and lateral side. The result is an upper that feels supportive and secure, but still comfortable. On top of that, the innovative BOA TX4 lacing system is like a bonus feature. Instead of traditional shoelaces, the FujiRado licenses technology from BOA, which got its start making closures for snowboarding and skiing equipment. The BOA system has three parts: a dial to adjust tension, a low-friction lace cable, and lace guides built into the uppers of the shoe. With an easy, on-the-fly turn, the dial pulls in the laces about 1mm per click. It also pops up to quickly release all the lace tension at once. Our wear-testers didn’t report any problems with the laces becoming tangled or releasing haphazardly. However, the micro-adjustment only works in one direction: tighter. Runners can quickly snug the laces down, but the only option to loosen the BOA TX4 is pulling out the dial for full release, then ratcheting it back down to the desired tightness. Additionally, while the BOA lacing system is innovative and works well, runners who use special types of lacing patterns to solve fit issues (heel lock or open forefoot, for example), won’t be able to do so with this system.
The FujiRado is a middle-of-the-road trail shoe in many ways, including agility. At 10.7oz (for men’s size 9), it isn’t terribly heavy or lightweight. With 3mm lugs that run heel to toe and edge to edge, it isn’t designed specifically for either soft ground or hardpack. Overall, the FujiRado doesn’t feel particularly agile on any one type of terrain, although our runners report that it performs adequately on a range of trails.
Likewise, the FujiRado doesn’t feel particularly responsive or particularly sluggish—just unexceptional and average. The firm midsole might feel more responsive paired with a lightweight 9oz platform designed for short trail races, but on a 10.7oz shoe, it just feels slightly out of place. The gel insert in the heel is intended to generate a lively, responsive feel, but it’s almost unnoticeable when surrounded by such firm foam.
The FujiRado does not have a rock plate (although some runners may assume it does after feeling how firm the midsole is), and sharp trail obstacles are noticeable through the sole. The stitched overlay toe bumper works well without being obstructive or feeling constrictive, and the midfoot overlays also protect the foot inside the upper. Although not waterproof, the closed-mesh toe box and mono-sock bootie do a fine job preventing some water and most trail dust from intruding into the interiors of the shoes.
Weight (oz)10.7
Heel Height23mm
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Reduce, Reuse, Recycle – How Conservationists Discovered a New Method of Reforestation in Costa Rica
Costa Rica Facts
In the mid-1990’s Costa Rica was faced with a problem: a sizeable chunk of natural forest had been reduced to degraded pasture lands. While these pastures once served as lush feeding grounds for cattle, they no longer held nutritional value and served as a sad reminder of what the beautiful forest once was. People soon found themselves asking, how can depleted land become fertile again? How can we restore what has been lost?
American conservationists Winnie Hallwachs and Daniel Janzen developed a new, shocking method of reforestation in Costa Rica. With the support of environmental consultants to the authorities of Costa Rica, this method may very well become the standard recycling method for plant matter.
Although the reduction of single use plastics and industrial farming practices are hot-button issues today, they were not as well known in the 1990’s. People were just beginning to understand the difficulties surrounding waste disposal and land depletion. When Hallwachs and Janzen proposed pairing up with a processing plant to restore the land, it was a new, bold idea.
Located near the Guanacaste reserve, the “Jugos del Oro” processing plant was an extremely active company producing juice for worldwide distribution. With the production of juice came unavoidable waste – primarily in the form of orange peels and pulp debris. Disposing of this waste was not only costly but difficult, considering that there were few disposal companies in the area that would take on such a large amount of plant matter. As a result, Jugos del Oro was paying high shipping fees to take their peels and pulp elsewhere.
Reusing Byproducts
Instead of seeing unusable waste, Hallwachs and Janzen saw room for opportunity. They posited that the Jugos del Oro byproducts could be used to help nourish the ailing natural forest. The team offered Jugos del Oro a vast area of forest to use as their dumping grounds in exchange for the donation of land. The company jumped at the offer, and began dumping tons and tons of peels into the Guanacaste forest.
In 2013 the conservationists returned to the land to see the results of their hopeful experiment. After 17 years, the biomass of the Jugos del Oro dumping grounds had increased a startling 176%. The experiment had succeeded beyond imagination.
Recycling in Costa Rica
What does this mean for the future of reforestation in Costa Rica? The scientists quickly learned that citrus peels not only nourish the land, but also act as a fertilizer; the Guanacaste soil produced a greater species of trees than anywhere else in the vicinity. Not only that, but the forest was built for longevity. As Janzen stated, “The intact rainforest does not burn, it cannot burn. It is too wet. When it is reforested and becomes a real live forest, it does not burn again.”
Scientists in Costa Rica are taking this method of recycling agricultural waste and running towards the future. As Costa Rica strives to go green by 2021, there is a greater focus being placed on finding new areas of forest to replenish. When an ecosystem thrives, so do the animals and people living within it.
Join us in fighting for a brighter future – support eco-friendly businesses and travel with Gecko Trail!
Posted By: Madison Elyse
Madison Elyse
Madison Elyse is a travel-obsessed adventure writer that moonlights as a yoga instructor, triathlete and fisherwoman. She lives in Girona, Spain.
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Costa Rica’s President Elect Blazes New Trails through Unprecedented Measures
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Arbuscular mycorrhizal associations in Lycopodiaceae
Winther, J.L.; Friedman, W.E., 2007: Arbuscular mycorrhizal associations in Lycopodiaceae. New Phytologist 177(3): 790-801
This study characterizes the molecular and phylogenetic identity of fungi involved in arbuscular mycorrhizal (AM) associations in extant Huperzia and Lycopodium (Lycopodiaceae). Huperzia and Lycopodium are characterized by a life cycle with long-lived autotrophic sporophytes and long-lived mycoheterotrophic (obtain all organic carbon from fungal symbionts) gametophytes. 18S ribosomal DNA was isolated and sequenced from Glomus symbionts in autotrophic sporophytes of seven species of Huperzia and Lycopodium and mycoheterotrophic Huperzia gametophytes collected from the Páramos of Ecuador. Phylogenetic analyses recovered four Glomus A phylotypes in a single clade (MH3) that form AM associations with Huperzia and Lycopodium. In addition, phylogenetic analyses of Glomus symbionts from other nonphotosynthetic plants demonstrate that most AM fungi that form mycoheterotrophic associations belong to at least four specific clades of Glomus A. These results suggest that most mycoheterotrophic plants that form AM associations do so with restricted clades of Glomus A. Moreover, the correspondence of identity of AM symbionts in Huperzia sporophytes and gametophytes raises the possibility that photosynthetic sporophytes are a source of carbon to conspecific mycoheterotrophic gametophytes via shared fungal networks.
Cervelli, D.; Tambasco, D.; Grussu, F.; Marianetti, T.; Gasparini, G.; Pelo, S., 2014: Fat grafting as adjunct refinement procedure in craniosynostosis management. Journal of Craniofacial Surgery 24(2): 691-692
Turczyński, J., 1993: Diagnostic difficulties and efficacy of electroconvulsive therapy in the treatment of lethal catatonia. This publication presents a case of 38-year old woman suffering from schizophrenia, whose body temperature reached 41 degrees C after she had taken 1250 mg of levomepromazine during a suicide attempt. Initially, the dominant symptoms were quantita...
Reis, F.; Petri, M., 1995: Cognitive function in SLE Role of race, education and antiphospholipid antibodies. Arthritis & Rheumatism 38(9 SUPPL ): S170
Parsonnet, V., 1998: Surface labeling on implantable pacemaker pulse-generators. Pacing and Clinical Electrophysiology 21(2): 484-484
Carrasco, L.; Gómez-Villamandos, J.C.; Bautista, M.J.; Hervás, J.; Pulido, B.; Sierra, M.A., 1996: Pulmonary intravascular macrophages in deer. Pulmonary intravascular macrophages (PIMs) have been found in the septal capillaries of deer lungs. Lung samples from adult deer were fixed in 2.5% glutaraldehyde, and then routinely processed for electron microscopy. The main features of the PIMs...
Wallace., 1867: The Parrots are regarded by the author as forming one family, Psittacidae, of the Zygodactyl Paarze. The Parrots are regarded by the author as forming one family, Psittacidae, of the Zygodactyl (Paarzehen) order, and are divided by him into five subfamilies-(1) Stringopinae, (2) Plictolophinae, (8) Sittacinae, (4) Psittacinae, and (5) Trichogloss...
Pers, T.H.; Timshel, P.; Ripke, S.; Lent, S.; Sullivan, P.F.; O'Donovan, M.C.; Franke, L.; Hirschhorn, J.N., 2016: Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes. Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important caus...
Ryhage, R.; Brandenberger, H., 1978: Negative ion mass spectrometry of phenothiazines. Mass spectra of a number of phenothiazines have been obtained by negative chemical ionization and compared with the corresponding mass spectra by positive chemical ionization and conventional electron impact. NH3, CH4, and N2O were used as reagent...
Kroll, C.; Schneider, F., 1987: Polyploidization of G2M phase cells separated from aerobically and anaerobically grown Ehrlich ascites tumor cells. G2-enriched fractions of Ehrlich ascites tumor cells (up to 80%-85% G2 cells) separated from anaerobically and aerobically cultured asynchronous populations by centrifugal elutriation revealed the same growth characteristics after recultivation un...
Chen, Z.P.; Chen, K.Y., 1994: Asparagine markedly induces the expression of ornithine decarboxylase gene in transformed mammalian cells but not in their untransformed counterparts. We have previously shown that asparagine alone induces a 10-15-fold increase in ornithine decarboxylase (ODC) mRNA level in DF-40 mouse neuroblastoma cells. The induction is due to an accumulation of ODC mRNA through a post-transcriptional stabili...
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Home Local Southern Utah man charged with murdering wife on cruise ship may receive...
Southern Utah man charged with murdering wife on cruise ship may receive plea deal
Gephardt Daily Staff
Kristy and Kenneth Manzanares. Photo: Facebook
JUNEAU, Alaska, June 15, 2019 (Gephardt Daily) — Federal court documents suggest that attorneys in the first-degree murder case of Kenneth Manzanares — the Utah man charged in the 2017 beating death of his wife, Kristy Manzanares, on an Alaskan cruise ship — are negotiating a plea deal.
Federal court documents filed Friday and obtained by Gephardt Daily show that prosecutor Bryan Schroder, Assistant United States Attorney for the District of Alaska, has filed for a motion of “expedited consideration.”
“A modification of the pre-trial deadlines is necessary in this matter as the
parties still do not anticipate a trial in this case and are actively working towards a
negotiated resolution in this matter,” Schroder’s request says.
“I have contacted the defendant’s counsel, Jamie McGrady, and she does
not oppose the United States request for filing on shortened time.”
The trial had been set for October of this year, and was expected to last about four weeks, federal court documents say. Manzanares had pleaded not guilty in the first-degree murder case. If convicted on that charge, he would face a maximum sentence of life in prison.
No details of any plea deal have been announced.
The Manzanareses had taken the Emerald Princess cruise, with their three daughters, to mark their wedding anniversary. The Santa Clara couple, reportedly high school sweethearts, both were 39.
On July 25, 2017, Kristy Manzanares was found, deceased on board the ship, with severe trauma to her head. Her husband was arrested.
According to documents filed in Anchorage shortly after the death, a witness identified as D.H., an acquaintance of the family, said Ken Manzanares answered his cabin door with blood covering his hands and clothing.
When D.H. entered the cabin, he saw 39-year-old Kristy Manzanares, the suspect’s wife, on the floor, covered with blood. The affidavit says that when D.H. asked why he did it, Kenneth Manzanares replied: “She would not stop laughing at me.”
Kenneth Manzanares
Kristy Manzanares
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Carnival cruise ships collide in Mexico
Paratroopers injured in training operation near Camp Shelby, Mississippi
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#ilovefreddys |
Brownsville – NOW OPEN!
2435 N Expressway
This franchise location is owned by OberRoc, LLC
Operated by South Texas Custard
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This location is owned by OberRoc, LLC
Freddy's Frozen Custard & Steakburgers is more than your traditional American hamburger restaurant. After your steakburger meal, make sure and try the freshly churned creamy desserts. The frozen custard desserts are richer, denser and creamier than ice cream and frozen yogurt. Make sure to let us know how our cooked-to-order food stands up against other Brownsville restaurants.
This Brownsville location serves movie-goers from Cinemark Movies 10, and shoppers from nearby Sunrise Mall.
Philly Cheesesteak Sandwich–NOW HERE!
Until 1/29/20
At all participating Freddy’s restaurants,
Warm up with a Freddy’s Frozen Custard & Steakburgers Philly Cheesesteak Sandwich! Sliced seasoned steak, sizzling grilled onions, green bell Read More
NESTLÉ® TOLL HOUSE® Cookie Concrete–NOW HERE!
Follow the crumbs into your favorite Freddy’s Frozen Custard & Steakburgers to try our new NESTLÉ® TOLL HOUSE® Cookie Concrete! Read More
Buy a gift, Get a gift — COMING SOON!
Your participating Freddy's restaurant,
It’s the season of giving, so we are giving you a FREE bottle of Freddy’s Famous Fry Sauce® or Freddy’s Read More
Come try a Bacon & Cheese Double Steakburger!
At Your Freddy's,
Two sizzling steakburger patties topped with two slices of crispy bacon, cheese, mustard, onion & pickle, all on a perfectly Read More
Freddy’s offers Philly Cheesesteak Sandwich and NESTLÉ® TOLL HOUSE® Cookie Concrete for a limited time
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers® takes a bite back in time with the return of the Philly Read More
Freddy’s introduces Blue Cheese Bacon Steakburger & brings back Pumpkin Pie Concrete
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers®, a fast-casual restaurant concept, announced today its newest limited-time offer, the Blue Read More
Freddy’s brings back Jalapeño Pepper Jack Steakburger and introduces Key Lime Pie Concrete
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers®, a fast-casual restaurant concept, announced today the return of the Jalapeño Pepper Read More
Finally: A favorite Wichita restaurant launches rewards app letting diners earn free stuff
Fellow FredHeads of Wichita: Just think of all the free steakburgers we could have earned by now if only this Read More
Freddy’s Frozen Custard & Steakburgers Opens First International Location
WICHITA, Kan. – Fast-casual restaurant concept Freddy’s Frozen Custard & Steakburgers announced today it has opened its first international location Read More
Meet The New Burger Kings—And The Rest Of America’s Best (And Worst) Franchises To Buy In 2019
Restaurateurs Randy Simon and Scott Redler wanted to eat griddle-fried burgers, frozen custard treats and Chicago-style hotdogs. So in 2002 Read More
FredHead Feed: Freddy’s Snacks
What’s the best way to spice up your day? A fantastic Freddy’s snack of course! Snacking throughout the day can Read More
FredHead Feed: Freddy’s Famous Fry Sauce®, It’s a Must Have!
When you order Freddy’s crispy shoestring fries, what is the one thing you must have with them? Freddy’s Famous Fry Read More
Freddy’s Presents Check of More Than $20,000 to the American Red Cross for Midwest Flood Relief
OMAHA, Nebraska – Wednesday morning, Freddy’s Frozen Custard & Steakburgers presented a check to the American Red Cross of Nebraska Read More
Freddy’s opens Tuesday in Brownsville
BROWNSVILLE, Texas – Freddy’s Frozen Custard & Steakburgers®, a fast-casual restaurant concept, opens Tuesday, March 5, at 2475 N. Expressway. Read More
FredHead Feed: Fish Is Back at Freddy’s Frozen Custard & Steakburgers
Who wants to go fishing at Freddy’s? Well, the hardest part of fishing is already done . . . now Read More
FredHead Feed: It’s Mint ’n Oreo® Time At Freddy’s
Looking for that cool, chocolatey treat to get you into the spring-season mood? Freddy’s Frozen Custard & Steakburgers has just Read More
FredHead Feed: You’re Invited! Celebrate Freddy’s 94th Birthday With Us
Birthday party, did someone say birthday party? Yes! Come celebrate Freddy’s birthday with us at all Freddy’s Frozen Custard & Read More
Freddy’s Frozen Custard & Steakburgers hits growth spurt at age 17
Although Freddy’s Frozen Custard & Steakburgers — based in Wichita, Kansas — has been around in for 17 years, it hit Read More
FredHead Feed: Where should we eat on Valentine’s Day?
How about Freddy’s! Looking for a great family restaurant to take the kids to on Valentine’s Day? Take them to Read More
All in the Family: Early Panera Franchisee Adds Freddy’s
As one of the first franchisees of Panera Bread Co., Mike Young still recalls the kitchen table conversation he had Read More
Young, Experienced, and Growing
From Busboy To Multi-Unit Operator Alex King may be only 29, but the Freddy’s Frozen Custard & Steakburgers multi-unit operator Read More
FredHead Feed: Top 5 Reasons to Celebrate Life’s Wins at Freddy’s
As we jump into a new year our minds swirl with ideas of ways to be healthier, spend more time Read More
FredHead Feed: 8 Delicious Menu Items That Can Be Ordered as a Lettuce Wrap at Freddy’s
Lettuce, lettuce, lettuce . . . the new thing! Ok, well, not so new, but a great alternative to Read More
FredHead Feed: Top 5 FredHead Instagram Posts of 2018
FredHeads are the best! They are enjoying life, food and friends at Freddy’s and sharing those moments with us Read More
FredHead Feed: Is Freddy’s open on New Year’s Eve and Day?
Happy New Year’s FredHeads! Is Freddy’s open on New Year’s Eve and Day? Yes! Join us on New Year’s Eve Read More
FredHead Feed: Is Freddy’s open on Christmas?
Happy holidays FredHeads! Is Freddy’s open on Christmas? All Freddy’s restaurants are closed on Christmas Day, Dec. 25, so our Read More
A.1.® Chop House Steakburger and Cookie Butter Concrete available at Freddy’s
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers® announced today the return of the A.1.® Chop House Steakburger and Cookie Read More
FredHead Feed: Holiday Shopping at Freddy’s – Free Seasoning, Fry Sauce or Jalapeno Fry Sauce with $25 Gift Card Purchase
Looking for restaurant gift card ideas? How about a Freddy’s Frozen Custard & Steakburgers $25 gift card AND Freddy’s seasoning Read More
FredHead Feed: Black Friday at Freddy’s – Free Seasoning, Fry Sauce or Jalapeno Fry Sauce with $25 Gift Card Purchase
Freddy’s Holiday Gift Card Promotion Starts Thursday
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers® announced today the start of its holiday promotion. With the purchase of a Read More
FredHead Feed: Freddy’s Spicy Chicken Sandwich is Back
Some of you are thinking, “yum, spicy!” and others are going, “yikes, spicy!” So which one is it? Well, our Read More
FredHead Feed: Fried Cheese Curds Available at Freddy’s
Whether you know exactly what fried cheese curds are or you hear “fried cheese” and say “I’m there!” – Freddy’s Read More
Freddy’s announces arrival of Spicy Chicken Sandwich and Pumpkin Pie Concrete
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers®, a fast-casual restaurant concept, is adding the Spicy Chicken Sandwich to its Read More
The Comfort-Food Burger Chain Expanding Across America
Founded in 2002, in Wichita, Kansas, Freddy’s Frozen Custard & Steakburgers now has more than 300 locations across 31 states Read More
FredHead Feed: Jalapeño Pepper Jack Burger is Back at Freddy’s
Want to add a little spice in your life? Check out our Jalapeño Pepper Jack steakburger. This burger recipe combines Read More
The Rumors Are True And Many Local Fans Can’t Wait
Corpus Christi, Texas–Amid initial rumors and about whether a popular Midwest fast food chain would really come to Corpus Christi, Read More
FredHead Feed: Better Than Your State Fair’s Funnel Cake Dessert
When you’re craving a funnel cake, you don’t always have to wait until the state fair comes around. Right now, Read More
Freddy’s features Jalapeño Pepper Jack Steakburger and Funnel Cake Sundae
WICHITA, Kan. – Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers®, announced today this year’s launch of the Jalapeño Pepper Read More
Freddy’s adds Cheese Curds to the menu
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers announced today the launch of its newest menu item, Cheese Curds. The Read More
Freddy’s Frozen Custard & Steakburgers Propels Nationwide Growth
WICHITA, Kan. – Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, announced it experienced significant growth in the first quarter Read More
Freddy’s opens its 300th restaurant in Indianapolis
INDIANAPOLIS – Growth continues to heat up for fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, with its newest opening Read More
Celebrate Freddy’s 93rd Birthday with 93-Cent Frozen Custard Treats
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers celebrates the 93rd birthday of its co-founder, namesake, and decorated World War Read More
Freddy’s Fish Baskets and Mint ‘n Oreo® Concrete are now available
WICHITA, Kan. – Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, is featuring two fan favorites from its seasonal menu, Read More
Freddy’s Frozen Custard & Steakburgers Signs First International Development Agreement
WICHITA, Kan. – Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, announced today it has signed a development and master Read More
A.1.® Chop House Steakburger available at Freddy’s
WICHITA, Kan. – The A.1.® Chop House Steakburger returns to the menu at Freddy’s Frozen Custard & Steakburgers on Thursday, Read More
Growth and Giving for Freddy’s in 2017
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers today released highlights of the company’s 2017 performance. Estimates for record-setting systemwide Read More
Freddy’s and SRG Flip the Fast Casual Script
With the launch of “This Good” campaign, Freddy’s embraces steakburgers and custard treats as ultimate indulgence in a balanced life Read More
Randy Simon Tapped to Lead Freddy’s Next Chapter
Freddy’s Frozen Custard & Steakburgers announced that Randy Simon was named CEO & president of the company he cofounded more Read More
Freddy’s Frozen Custard & Steakburgers Debuts New Fall-Inspired Menu Lineup
WICHITA, Kan. – Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, announced today the launch of its fall menu, which Read More
Freddy’s Celebrates National Frozen Custard Day on August 8
Locations nationwide to offer $1 off frozen custard treats and donate to Kids In Need Foundation WICHITA, Kan. – In Read More
Hatch Green Chiles and Funnel Cake Sundae return to Freddy’s
WICHITA, Kan. – Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, brings back two of its most popular seasonal Read More
Fish entrées return to Freddy’s along with Mint ‘n Oreo Concrete
Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, brings back two seasonal favorites, the Fish Sandwich or Fish & Chips Read More
92-cent frozen custard treats at Freddy’s
WICHITA, Kan. – Fast-casual restaurant concept, Freddy’s Frozen Custard & Steakburgers, celebrates the 92nd birthday of its co-founder and namesake, Read More
Freddy’s to surpass 2016 record, prepares for 70 new restaurants in 2017
WICHITA, Kan. – Freddy’s Frozen Custard & Steakburgers wrapped up a year of record growth in 2016 and is poised Read More
Philly Cheesesteak returns to Freddy’s menu
Freddy’s Frozen Custard & Steakburgers takes a bite back in time with the return of its Philly Cheesesteak sandwich on Read More
Freddy’s opens five restaurants in a single day, 50 for the year, more to come
Freddy’s Frozen Custard & Steakburgers opened five restaurants on November 8, the most ever for the company on a single Read More
Freddy Simon featured as ABC World News Tonight’s ‘Person of the Week’
Freddy’s Hits 200-Unit Count with New Omaha Store
Freddy’s Frozen Custard & Steakburgers will open its newest Omaha, Nebraska, location on Thursday, June 9, at 7201 Military Avenue. Read More
Freddy’s to commemorate first restaurant in Wichita
Freddy’s Frozen Custard & Steakburgers will unveil a plaque this week to mark its first restaurant location, according to a Read More
The Humble Men Behind Freddy’s
Freddy’s Frozen Custard and Steakburgers is one of the fastest-growing restaurant chains in the country. In 2015, the restaurant saw Read More
Franchise Times: Freddy’s namesake is ‘living brand’
From the classic diner design to the comfort food inside, Freddy’s Frozen Custard & Steakburgers radiates post-war optimism. That feeling Read More
The Pioneer Woman: Freddy’s Burgers
My family loves—I mean loves—Freddy’s Frozen Custard and Steakburgers, otherwise known as “Freddy’s.” A location opened about an hour from Read More
About Freddy’s
Enjoying great food without a long wait doesn’t mean your meal has to be cooked before you order it.
The tasty food of Freddy's is now available as a gift!Freddy's gift cards are redeemable at any Freddy's location nationwide.
Copyright © 2020 Freddy's Frozen Custard & Steakburgers. Sitemap.
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Film Feature: Navigating the 55th Chicago International Film Festival
Submitted by PatrickMcD on October 14, 2019 - 12:19pm
Architecture X Design
Black Perspectives
Cinemas of the Americas
Industry Days
New Directors
U.S. Indies
Women in Cinema
CHICAGO – The Windy City’s greatest annual cinema celebration is upon us, and the 55th Chicago International Film Festival is about to crank up the projection machines for 11 days of amazing cinema treats, from October 16th through the 27th, 2019. How does a film buff or curious participant navigate the waters of the festival? HollywoodChicago.com is here to guide you.
Podtalk: Frank Carr of ‘YippieFest,’ at the Prop Theatre in Chicago, Aug. 16-18, 2019
Submitted by PatrickMcD on August 16, 2019 - 3:50pm
Famous in the Future
Frank Carr
Podtalk
Prop Thtr
Richard Cotovsky
Yippie
YippieFest
CHICAGO – It’s the 3rd annual YippieFest in Chicago at the Prop Thtr (Theatre), and the three days of Theater, Performance, Music, Film, Comedy and more kicks off with its 2019 edition on Friday, August 16th (7pm), and runs through Sunday, August 18th. The Fest evolved from the spirit of Mary-Arrchie Theater’s Abbie Hoffman Fest, which began 30 years ago (1989), and ended in 2016. The Fest also celebrates the 50th Anniversary of the Woodstock music festival, which coincides with the weekend. For more information on YippieFest, including tickets, click here.
Feature: Navigation Guide to the 54th Chicago International Film Festival, Oct. 10-21, 2018
Submitted by PatrickMcD on October 9, 2018 - 11:37am
Because Life is a Movie
CHICAGO – Having an international film festival is one of the reasons Chicago became an international city, and the 54th Chicago International Film Festival is about to crank up the projection machines for 11 days of amazing cinema treats, from October 10th through the 21st, 2018. How does an film buff or curious participant navigate the waters of the festival? HollywoodChicago.com is here to guide you.
Podtalk: Desiree Burcum of ‘Yippie Fest,’ at the Prop Theatre in Chicago, Aug. 17-19, 2018
Submitted by PatrickMcD on August 17, 2018 - 8:06am
Desiree Burcum
Michael Hora
The Whole World is Watching
Tina Teske
Yippie Fest
CHICAGO – It’s the 2nd annual Yippie Fest in Chicago at the Prop Thtr (Theatre), and the three days of Theater, Performance, Music, Film, Comedy and more kicks off with the 2018 Opening Ceremonies on Friday, August 17th, and runs through Sunday, August 19th. The Fest evolved from the spirit of Mary-Arrchie Theater’s Abbie Hoffman Fest, which ran from 1989 to 2016. The Fest also celebrates the 50th Anniversary of the Yippies (Youth International Party) in Chicago, during the Vietnam protests in August of 1968. The whole world was watching. For more information on Yippie Fest, including tickets, click here.
Podtalk: Josh Hope, Co-Director of the Windy City International Film Fest, July 12-15, 2018
Submitted by PatrickMcD on July 12, 2018 - 7:14am
Acting in Chicago
Biograph Theater
Mindy Fay Parks
Screenplay Finalist
Victory Gardens
Windy City International Film Festival
CHICAGO – This is Year Two for the Windy City International Film Festival (WCFF) – from Thursday, July 12th to Sunday, July 15th, 2018 – and the festival that celebrates indie filmmaking both locally and internationally will have its screenings at Chicago’s historic Biograph Theater (2433 North Lincoln Avenue). Also for the second year, the festival is co-directed by Mindy Kay Parks and Josh Hope. For a complete weekend schedule, click here.
Film Review: ‘Get Out’ is Funny, Scary & Tells Us About Us
Submitted by PatrickMcD on February 24, 2017 - 10:11am
Guess Who is Coming to Dinner
Key & Peele
LilRel Howery
CHICAGO – When he got his chance, writer/director Jordan Peele (“Key & Peele”) completely understood what he had to do – combine his skewered hilarity, love of horror movies and true social conscience, and put them all into one great movie. Ladies and germs, “Get Out.”
Film Review: Schizophrenic ‘Top Five’ is Evolution for Chris Rock
Submitted by PatrickMcD on December 12, 2014 - 4:05am
Tracy Morgan
CHICAGO – Chris Rock wants you to take him seriously, so he has made a comedy with inconsistent laughs, and a nod towards the weird fishbowl lives that today’s celebrities endure. It’s a rare film where the last part is stronger than the first few acts, a mishmash that is “Top Five.”
Interview: Deon Cole Hosts ‘Conan’ Writers at Just for Laughs Chicago
Submitted by PatrickMcD on June 13, 2012 - 8:15am
Deon Cole
Just for Laughs Chicago
Laugh Factory
CHICAGO – While the “Conan” show spends a week in Chicago during the TBS “Just for Laughs” comedy festival, some of his writing staff are showcasing their talents around town in a couple venues. Comedian and “Conan” writer Deon Cole hosts and performs at these events.
Interview: T.J. Miller on His Chicago-Inspired Comedic Sensibility
Submitted by PatrickMcD on August 3, 2011 - 2:23pm
Our Idiot Brother
She’s Out of My League
Successful Alcoholics
CHICAGO – T.J. Miller is not yet a household name, but his comic stylings are memorable in such films as “Cloverfield,” “She’s Out of My League,” “Gulliver’s Travels” and the upcoming “Our Idiot Brother.” Those comedic roots are in Chicago, doing stand-up and improv here.
Theater Review: Ellen DeGeneres Brings Laughs, Magic to Chicago Theatre
Submitted by Alissa Norby on June 17, 2010 - 11:41pm
Alissa Norby
Ellen's Somewhat Special Special
Theater, TV, DVD & Blu-Ray
CHICAGO – “I like the word ‘somewhat’”, mused Ellen DeGeneres Wednesday night onstage at the Chicago Theatre in front of what is now her standard roused audience. “Like you can say, ‘I’m somewhat gay. But my girlfriend’s really gay.’”
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Kim Kardashian Admits She Wants To Take Down Kylie Jenner On Instagram Again — Watch
‘American Horror Story: Freak Show’ Recap: Two Deaths In Jupiter
October 30, 2014 12:15AM EDT
Suge Knight Arrested For Stealing Camera From Female Photographer
Susan Johnson
Rapper Suge Knight was arrested, along with comedian Katt Williams, on Oct.29 for allegedly stealing a female photographer’s camera in Beverly Hills on Sept. 5. The incident, which reportedly left the photographer with ‘minor injuries,’ may land Suge in jail for 30 years or more.
Suge Knight, 49, has had a lot of run-ins with the police this year. After getting shot six times at Chris Brown‘s pre-VMAs party, he was detained in Las Vegas on Oct. 29 after allegedly stealing a female photographer’s camera. Comedian Katt Williams, 41, was also charged with felony robbery during the incident, which took place in Beverly Hills on Sept. 5.
Suge Knight Arrested — Locked Up In Jail For Stealing Photographer’s Camera
The two men are being charged with stealing an independent celebrity photographer’s camera outside of a studio in Beverly Hills. The men reportedly chased her down and grabbed her “forcibly,” which left her with minor injuries, according to the Daily Mail.
Katt was arrested when he showed up for court on Oct. 29 for the assault case and robbery, TMZ reported.
Though the investigation remains open, if found guilty, Suge will face significantly more jail time than Katt because of a previous assault with a deadly weapon conviction. Suge may serve as much as 30 years to life in prison, while Katt faces up to seven years in custody.
Suge Knight’s Shooter Identified By Police: Why They Still Can’t Make An Arrest
Suge was a victim in a violent shooting during Chris’s VMAs pre-party, where he was shot six times. Though suspects have been identified through security footage at the club, no arrests have been made.
It seems that no one is willing to talk to the LAPD about the gunman’s identity. And police do not have enough evidence to make any arrests.
— Julianne Ishler
San Francisco Giants Win The World Series
Kim Kardashian Shows Off New Extreme Waist-Training Corset Pic
Ian Somerhalder Thinks Nikki Reed Is ‘The One’
Katt Williams Suge Knight
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› Future Business Leader - Training Programme
Future Business Leader - Training Programme
KPMG in Cyprus will provide a high calibre training and practice programme to 50 Chinese students, titled: “Future Business Leader”.
12 July 2018 - 10 August 2018, 9:00AM - 5:30PM, EET
KPMG in Cyprus will provide a high calibre training and practice programme to 50 Chinese students, titled: “Future Business Leader”. KPMG in Cyprus will collaborate with both ZBG Rising Star Co. Ltd and D. Yang Sunflower Ltd for the completion of this project.
The training and practice programme is scheduled to take place at KPMG’s premises, which will commence as of 12/7/2018 and end on 10/8/2018.
A series of trainings in regards to Audit and Assurance and Strategic Planning will be offered, along with a presentation competition, followed by a graduation ceremony, which will be organised during the first stage of the programme. The sessions will be delivered by Board Members and Managerial staff employed at KPMG in Cyprus, who possess robust technical and soft skills expertise.
The second stage of the programme entails apprentice shadowing. The trainees will be allocated to several groups (Audit, Tax and Advisory) at KPMG’s Nicosia, Larnaca and Limassol offices. A mentor will be assigned to apprentices and will be responsible for offering guidance and supervision throughout the project.
The training and practice programme aims at enhancing the participants’ background, developing their employability skills and building their international social network, with the ultimate objective being to help them better understand the current business environment as well as their future tasks and responsibilities.
Christos V. Vasiliou
Managing Director and Head of Advisory Services
Find office locations kpmg.findOfficeLocations
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Contact Alumni
News and Perspectives
© 2020 KPMG Limited, a Cyprus limited liability company and a member firm of the KPMG network of independent member firms affiliated with KPMG International Cooperative (“KPMG International”), a Swiss entity. All rights reserved.
KPMG International Cooperative (“KPMG International”) is a Swiss entity. Member firms of the KPMG network of independent firms are affiliated with KPMG International. KPMG International provides no client services. No member firm has any authority to obligate or bind KPMG International or any other member firm vis-à-vis third parties, nor does KPMG International have any such authority to obligate or bind any member firm.
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The Journal Record
Latest Gerry Connolly News
Democrats, and some in GOP, seek more info on Iran decision
WASHINGTON (AP) — The Trump administration made its case on Capitol Hill for killing a powerful Iranian general, but Democrats — and a handful of Republicans — said the classified briefings Wednesday were short on details and left them wondering about the president's next steps in the...
Articles of impeachment: Explaining what's next in the House
Dec. 6, 2019 12:06 AM EST
WASHINGTON (AP) — House Speaker Nancy Pelosi said Thursday that Democrats will draft articles of impeachment against President Donald Trump, a crucial step toward a vote of the full House. The articles are likely to mostly encompass Democrats' findings on Trump's dealings with Ukraine. Democrats are still...
Oklahoma Business News
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Ryan Zinke on Principles & Values
Endorsed Young Gun candidate in national Republican "Drive to 245".
Zinke is endorsed by National Republican Congressional Committee 2014 targeting
The National Republican Congressional Committee has defined three categories in its "Young Guns" list, and a new fundraising website Drive to 245. Inclusion in the program indicates funding from the NRCC to the candidates, mostly via PAC-funded TV advertising:
Press Release from NRCC
The first level of the program: "On the Radar" candidates are individuals running in competitive congressional seats. They have met the minimum threshold in campaign organization and show potential to achieve greater status in the program as the cycle progresses.
"Contender" is the second level of the Young Guns program. Contender candidates have completed stringent program metrics and are on the path to developing a mature and competitive campaign operation. They are in congressional seats that appear favorable to the GOP candidate.
"Young Gun" is the highest level of the Young Guns program. These candidates have met a series of rigorous goals and surpassed program benchmarks to establish a clear path to victory.
Source: NRCC Targeted District 14-NRCC on Oct 9, 2014
Member of the Republican Study Committee.
Zinke is a member of the Republican Study Committee
Organizational Self-Description: The Republican Study Committee (RSC) has served as the conservative caucus of House Republicans and a leading influencer on the Right since its original founding in 1973. It exists to bring like-minded House members together to promote a strong, principled legislative agenda that will limit government, strengthen our national defense, boost America's economy, preserve traditional values and balance our budget.
The RSC provides the tools and research that members of Congress need to craft and advance policies that will benefit the American people. It also provides a forum for like-minded members to join together to support common causes and challenge the status quo. By doing so, the RSC ensures that conservatives have a powerful voice on every issue coming before the House, whether it is the economy, health care, defense, social safety net reform, or Washington's dangerous, out-of-control spending.
We believe that the appropriate role of a limited government is to protect liberty, opportunity, and security, and that it is the responsibility of this generation to preserve them for the next. We believe that more government is the problem, not the sol Source: Republican Study Committee poress release 16-RSC on Jan 1, 2016
Click here for definitions & background information on Principles & Values.
2016-17 Governor, House and Senate candidates on Principles & Values: Ryan Zinke on other issues:
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The Budget 2015
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E-learning for everyone!
Education by Contributing Authors | on May 30, 2016 | 0 comments | in Op-ed | Like it
Hong Kong has launched a free electronic learning (e-learning) programme for all primary and secondary school students. It’s a mirror of a programme that began in the US two years ago.
Hong Kong has launched a free electronic learning (e-learning) programme for all primary and secondary school students. It’s a mirror of a programme that commenced in the United States two years ago.
The free e-learning programme in the US was wholly sponsored by Environmental Systems Research Institute (Esri), a private enterprise that focuses on Geographic Information System (GIS) software development. The sponsorship programme was a response to President Barack Obama’s warning that those nations that “out-educate us today will out-compete us tomorrow.”
Computers are not new to US students. Nearly 70 percent of teachers or students have been using them in classrooms since 2009, according to a government survey. However, US student performance in STEM subjects (science, technology, engineering and mathematics) has fallen behind that of other developed countries. In the 2009 OECD “Programme for International Student Assessment” (PISA) for 15-year-old pupils, held in 65 countries, students from the US ranked only 23rd in science, and 31st in mathematics, while peers from Japan and South Korea were among the top four to six.
In response to President Obama’s ConnectED initiative which aims to enrich education for every student in America through electronic learning, Esri’s president, Jack Dangermond then decided to support free usage of the company’s GIS software by all US kindergarten, primary and secondary school students. This programme would benefit over 100,000 schools.
Sponsored students can use GIS software and related professional map analysis tools originally developed for the government, public and private enterprises. Even better, they can use this cloud system on their smartphones, tablets and desktops anywhere. Through this initiative, Dangermond hopes to improve students’ problem solving abilities.
As the Chairman of Esri China (HK), I feel proud when hearing such news. Deep down, I have always thought of bringing this educational programme to Hong Kong so as to inspire our students in the STEM disciplines so that they may enjoy the learning process. After consultations with our US headquarters and the Hong Kong Education Bureau, the free Map in Learning (MiL) electronic education programme finally landed in Asia this year.
The MiL Programme corresponds with the Education Bureau’s “Life-wide Learning” paradigm, which prescribes student learning in real-life and authentic contexts. It provides students with a timely GIS analytical platform and relevant knowledge, trains students to take full advantage of geographic information and enriches their learning experience.
Students use the GIS platform
Information already available on the GIS software platform includes demographic data (population and income), locations of local community facilities (libraries, beaches and schools), as well as global data on GDP, weather and even plate tectonics. Students can also upload other information to the platform.
We started to contact local schools late last year and the response has been overwhelming! Over 80 schools have enrolled in the programme. Amazingly, some youngsters have already utilised the software to explore the design of a footpath through an amenity area within their school compound.
I sincerely hope that the programme will stimulate students’ interest and enhance their learning ability while nurturing a pool of talent for the smart city of Hong Kong!
Dr Winnie Tang is Founder and Chairman of the Steering Committee of the Smart City Consortium and is a pioneer in bringing Geographic Information System (GIS) technology to Hong Kong. Over the years, she has advocated the use of technology in sectors including environmental conservation, education and healthcare.
Latest posts by Contributing Authors (see all)
How “World-class” are Cities in the Greater Bay Area? (including Hong Kong) – March 25, 2019
We mean business in climate action – November 8, 2018
Don’t undervalue PRL sports clubs’ economic and wider contributions to Hong Kong – October 4, 2018
Hong Kong needs to get smart on smart cities in ASEAN
Shipping Out: Week In Review – Taal Volcano soon to burst, Wuhan virus crosses more borders
Listen: Talking Taiwan’s presidential election on podcast launch
Hong Kong, China, and the Taiwan elections: An electoral civil war
Art as resistance at Hong Kong’s anti-government protests: photo essay, part 2
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LWF 2016 signs up for Bottlebooks UK launch
By Mathew Lyons
Published: 02 February, 2016
The London Wine Fair is to partner with wine-data platform Bottlebooks for its upcoming 2016 show, the two companies have announced.
Bottlebooks will be hosting the fair's official digital directory and will also launch a standard platform for wine-data capture in the UK.
Bottlebooks offers all stakeholders in the trade a comprehensive and reliable single-source data platform.
Producers can enter comprehensive information about their products, including a range of sales data, product descriptors, and logistics information across 162 fields.
Bottlebooks believes it has an opportunity to profoundly improve and integrate business processes for all parts of the sector, from importers, agents and wholesalers to retailers and sommeliers.
Other services offered by the site include the management of logistics and duty data, the development of portfolios and wine lists, and the hosting of consumer and trade wine events.
Bottlebooks will be available to both LWF exhibitors and their suppliers for an annual fee of £77. Exhibitor micro-sites for the fair are priced at £135.
Bottlebooks is also providing a range of bespoke features for the event, including taste-driven searches, an industry briefing booking system and on-stand tasting schedules.
LWF is the first major event to partner with Bottlebooks.
Jonathan Harclerode, founder and chief executive of Bottlebooks, said: "We decided to enter the UK market because of its reputation in the wine world as an innovator. As the second largest import market for wine, the UK trade is constantly developing new ways to discover, review, promote and sell great wine.
Bottlebooks logo
"Most of these innovations start with having comprehensive wine information, and Bottlebooks is proving to be a natural fit. The London Wine Fair is at the heart of the UK trade; it is the platform for information exchange and as such was the perfect partner choice for us."
Ross Carter, director of the London Wine Fair, said: "Bottlebooks is set to change the way the global wine industry does business, providing real, workable solutions for real, everyday problems for everyone working in this sector. We are delighted they have elected to launch in the UK and we are proud to partner with them."
Philip Tuck MW, wine director of Hatch Mansfield, which is an early adopter of the service, said: "We think the Bottlebooks initiative to provide a standard way to exchange wine information and data could have significant cost and time benefits for the entire trade. If it can be made to work, it will be a win-win situation for producer, importer, retailer and consumer alike."
Bottlebooks was founded in 2013 by Jonathan Harclerode, a former senior manager in Accenture's emerging technology innovation team.
Its has already been adopted by over 1,000 wine business worldwide.
The 2016 London Wine Fair will take place between May 3 and 5 at the Olympia, Kensington.
A brief introductory film about the Bottlebooks platform is available online here.
To sign up to the London Wine Fair Bottlebooks portal, please email David Lees.
LWF logo 2016
HWS - Nigel Huddleston
Mathew Lyons
LWF 2016
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Wine Australia to showcase diversity at ProWein
ADT 2017 promises focus on premiumisation and innovation
Koshu London wine tasting enters eighth year
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Stanford Health Policy is a joint effort of the Freeman Spogli Institute for International Studies and the Stanford School of Medicine
Rosenkranz Prize
Rosenkranz Symposium
PhD Job Market
CHP/PCOR
Program Co-Directors:
Douglas Owens, MD, MS, Associate Director, Ci2i, Veterans Affairs Palo Alto Health Care System, Professor of Medicine (General Internal Medicine) and by courtesy, of Health Research and Policy, and Core Faculty Member, Center for Health Policy/Center for Primary Care and Outcomes Research, Stanford University
Ranak Trivedi, PhD, Core Investigator, Ci2i, Veterans Affairs Palo Alto Health Care System, Assistant Professor (Psychiatry and Behavioral Sciences), and Affiliate, Center for Health Policy/Center for Primary Care and Outcomes Research, Stanford University
Program Associate Director:
Steve Asch, MD, MPH, Director, Ci2i, Veterans Affairs Palo Alto Health Care System, Professor of Medicine (General Medical Disciplines), and Affiliate, Center for Health Policy/Center for Primary Care and Outcomes Research, Stanford University
Mary K. Goldstein, MD, MS, Director, Geriatrics Research Education and Clinical Center (GRECC), Veterans Affairs Palo Alto Health Care System, and Professor of Medicine (Center for Primary Care and Outcomes Research) and Professor of Health Research and Policy, Stanford University School of Medicine
CENTER FOR HEATH CARE EVALUATION
VETERANS AFFAIRS PALO ALTO HEALTH CARE SYSTEM
AND STANFORD UNIVERSITY
Fellows are offered an opportunity to combine formal training in Medical Informatics with research applying Medical Informatics to areas of relevance to the VA health care system.
Fellows will:
Acquire skills in state-of-the-art Medical Informatics;
Gain insight into major current issues in Medical Informatics that are relevant to VA clinical, educational, and research programs;
Develop expertise in conducting collaborative and interdisciplinary Medical Informatics research;
Acquire further training in such areas as medical decision-making, information technologies, communications tasks of medical practice, and information systems through seminars and formal coursework.
Fellows will obtain focused training in medical informatics while also having the opportunity to complete foundational coursework in (1) essential health services research methods, (2) implementation sciences and systems redesign, and (3) research in collaboration with operational partners.
Fellows can pursue more advanced work in the context of medical informatics through concentrations:
Health Informatics Concentration: Clinical decision support; computerized order entry and alerts; healthcare information exchange; population health; big data and learning healthcare systems.
Health System Redesign/Implementation Science Concentration: Organizational innovation for value production; implementation design and evaluation.
High-Value Health Care Concentration: Health economics; outcomes research; clinical decision making; health policy.
Fellows will develop an individualized training plan through the guidance of a mentoring committee that will include a career mentor, faculty mentor(s) and implementation/operational partner mentor.
Medical Informatics Research
Research opportunities in medical informatics are aligned with the broader research goals of (1) fostering high value mental health care, (2) fostering high value specialty care for chronic disease, and (3) advancing methods to assess and improve value.
Medical Decision-Making, Clinical Decision Support Systems and Knowledge Acquisition.
Using analytic approaches to aid development of screening and treatment strategies.
Designing clinical decision support systems for different medical conditions.
Enhanced User Interface Projects and Related Research.
Quality of Care and Program Evaluation.
Developing a prototype for manipulation and transfer of electronic medical record data for evaluation of process/quality of care and health outcomes.
Accounting for quality of life and patient preferences in guiding treatment decisions.
Current Funded Research: Decision Support Systems for Hypertension and Chronic Pain.
Postdoc fellows would work on two currently funded projects: Decision support for hypertension and decision support for chronic pain. These projects focus on methods by which information can be retrieved and utilized more selectively and effectively via processes that: (1) facilitate access to and use of the most relevant patient information for a given need, (2) enhance the electronic exchange, organization and presentation of information in clinical, research and educational settings, (3) use medical ontologies and knowledge bases for storing evidenced based medicine information.
Applicants must be U.S. citizens who have completed an MD and accredited residency or a PhD in computer sciences, medical informatics, decision sciences, economics, or related fields. Applicants with strong quantitative and computer science backgrounds will be given priority. The VA is an equal opportunity employer.
Applicants will be evaluated on their professional training and development to date, professional statement, demonstrated productivity and recommendations. Final selection of fellows will be based on a personal interview.
Professional statement. Applicants should submit a brief statement (not to exceed one single-spaced page) of their research activities and career goals and objectives, how they can contribute to the objectives of the training program, and how the program can contribute to the applicant’s professional development.
Demonstrated productivity. Applicants should provide details on education, professional activities and relevant achievements. In addition, applicants are asked to supply two examples of their work.
Recommendations. Three written letters describing the applicant’s competence, an estimate of how the applicant's performance ranks in relation to that of their peers, and the likelihood of the applicant making a contribution to the field of Medical Informatics.
Interview. After an initial screening phase, top candidates will be interviewed.
VA Contact: Ranak Trivedi, PhD
Center for Innovation to Implementation
VA Palo Alto Health Care System
Menlo Park Division (152)
795 Willow Road, Menlo Park, CA 94025
Fax: (650) 617-2736 / Email: Ranak.Trivedi@va.gov
Stanford Contact: Benjamin Priestley
Center for Health Policy / Center for Primary Care and Outcomes Research
Encina Commons
615 Crothers Way
Phone: (650) 497-1191 / Email: bpriestl@stanford.edu
To apply, click here.
Please be prepared to upload a CV, statement of career objectives and the names of three professional references.
Fellowship Coordinator
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Startup Watchlist: 11 Indian IoT Startups To Watch Out For In 2018
Suprita Anupam
11 IoT Startups That Might Disrupt The Indian Market With Their IoT-enabled Products
This article is part of Inc42’s Startup Watchlist annual series where we list the top startups to watch for 2018 from industries like AI, IoT, Blockchain etc. Explore all the stories from ‘Startup Watchlist’ series here.
Once used as a tool for an application, Internet of Things (IoT) has become one of the widest ecosystems today. Currently at the centre stage of industries like energy management, healthcare, logistics, fintech, manufacturing and agritech, IoT, in convergence with AI, has the potential to disrupt all these verticals.
Previously dictated by big players like IBM, Google, Intel, Cisco, Ericsson, Apple and Amazon, the IoT space has now become a startup ecosystem enabler across the world. While it was the Internet that drove the emergence of ecommerce startups in the early 2000s, IoT has been facilitating the growth of this decade’s tech startups.
What lightning does to mushrooms, IoT has done to startups!
As the name suggests, the IoT is a global platform, so are the startups based upon. On the one hand, Indian IoT startups are going global. On the other, IoT startups from the US, the UK, Middle East and Singapore aim to set their operations in India.
IoT: Market, Startups, And Segmentation
It is estimated that the IoT space will garner $6 Tn worth of investments between 2015 and 2020. As per a report by IDC, the global IoT market is set to hit $1.7 Tn by. While the worldwide spending on IoT currently stands at $674 Bn, the spending is expected to reach $772.5 Bn in 2018, which is an increase of 14.6%.
IDC’s Worldwide Semiannual Internet of Things Spending Guide forecasts that the worldwide IoT spending will grow at a CAGR of 14% between 2017 and 2021, surpassing the $1 Tn mark in 2020 and reaching $1.1 Tn in 2021.
According to Carrie MacGillivray, VP, IoT and Mobility at IDC, by 2021, more than 55% of spending on IoT projects will be on software and services. This is directly in line with the results of IDC’s 2017 Global IoT Decision Maker Survey, where organisations have indicated that software and services are the key areas of focused investment for their IoT projects.
Software creates the foundation upon which IoT applications and use cases can be realised. However, it is the services that help bring all the technological elements together to create a comprehensive solution that will benefit organisations and help them achieve a quicker time to value.
Coming to India, IoT market here is poised to touch $15 Bn by 2020, according to the trade association of Indian IT and BPO industry, NASSCOM. Fueled by a $1 Bn investment from the Indian government every year for building 100 smart cities, the trade association also predicts that by 2020, India will account for nearly 5% of the global IoT market.
Out of existing 971 IoT startups in India, 70% of the startups emerged after 2010. Interestingly, Bengaluru remains the hub as it is home to 51% of these startups, down by 4% from the 55% in 2016. The 971 IoT startups are evenly distributed among segments such as healthcare, transport, agritech, services and logistics.
With 47% of the Indian IoT startups catering to consumers and building solutions such as wearables, connected vehicles and connected appliances and 40% catering to enterprises, the IoT startups have been broadly divided into two categories: Industrial IoT and Consumer IoT.
IoT: Startup Funding
IoT startups are now leading the platform with giants following them either through investments, fundings or acquisitions. As mentioned globally, the space is set to witness $6 Tn worth of investments between 2015-2020. Indian startups too are being incubated globally/by global players.
According to Zinnov, in India, 120 IoT startups have received over $169 Mn funding since 2006 (till may 2017). Large investors that have created IoT focused investment funds are Tiger Global Management, Blume Ventures and Qualcomm Ventures.
Honeywell Ventures and a Tokyo-based venture fund Trend Micro have launched investment funds, with of a corpus of $100 Mn each, to invest in IoT-based startups. Blume Ventures, one of the most active VCs in India, has recently announced plans to launch a $100 Mn Investment Fund III that will also have a focus on IoT startups.
Among the other VCs like Sequoia Capital, Artiman Ventures, Qualcomm Ventures, Kalaari Capital, Pi Ventures and Maverick Capital Ventures are among the few that are actively looking to invest in IoT startups.
Based on funding, disruptive solutions offered, scalability and founders’ background, let’s check out the list of Indian IoT startups that are a must watch in 2018!
11 Indian IoT Startups To Watch Out For In 2018
Stellapps
Founded by IITians Ranjith Mukundan and Venkatesh Seshasayee in 2011 and incubated by IIT Madras, Bengaluru-based Stellapps offers end-to-end dairy technology solutions. The startup produces and procures comprehensive farm optimisation and monitoring support solution to help dairy farmers and cooperatives maximise profits while minimising effort.
Stellaps Fact Sheet
Funded by Omnivore Capital, Stellapps leverages Internet of Things (IoT), Big Data, cloud, mobility, and data analytics to improve agri-supply chain parameters, including milk production, milk procurement, cold chain, animal insurance and farmer payments.
The SmartMoo IoT router and in-premise IoT Controller acquire data via sensors that are embedded in milking systems, animal wearables, milk chilling equipment and milk procurement Peripherals. They transmit the same to the Stellapps SmartMoo Big Data Cloud Service Delivery Platform (SDP).
The SmartMoo suite of applications then analyses and crunches the received data before disseminating the analytics and data science outcome to various stakeholders over low-end and smart mobile devices.
In July 2017, Stellapps had raised an undisclosed amount of Series A funding from Blume Ventures, Flipkart Group CEO Binny Bansal, and Venture Highway. Earlier, the Indian startup had received an undisclosed amount of funding from venture capital firm Omnivore Partners in 2013.
There are a number of companies such as Sumangalam Dairy Farm Solutions, VieMilk Engineering and Vansun Technologies which provide automatic milking solutions. However, Stellapps, which has set the world’s largest community milking parlour, has a huge local market to cater to with its IoT-enabled dairy solutions.
Zenatix
Founded by Amarjeet Singh, Rahul Bhalla and Vishal Bansal in 2013, Zenatix is a data-driven energy efficiency company using advanced machine learning based models to provide significant energy savings for large commercial consumers of electricity.
Zenatix Fact Sheet
The Gurugram-based IoT startup’s offerings include WattMan that aims to help retail and BFSI businesses save up to 30% of their energy bills. The solution ensures governance, quality of service, and risk mitigation across the distributed infrastructure through automated and intelligent controls claims the company.
The product hardware includes components such as sensors for monitoring energy, temperature, humidity, and other important parameters. It also includes control equipment for automated control of ACs and signages. WattMan’s cloud-based software provides accessibility and can be configured over the web and mobile.
Related Article: Startup Watchlist: 10 Indian AI Startups To Watch Out For In 2018
In April 2017, Zenatix, had raised about $1 Mn Pre-Series A funding led by Pi Ventures. Existing investor, Blume Ventures, also participated in the round. Prior to this in July 2015, Zenatix had raised $161K led by Google country chief Rajan Anandan; Snapdeal’s cofounders Kunal Bahl and Rohit Bansal; and Trifecta Capital’s Rahul Khanna among others. In December 2015, it raised an undisclosed amount of follow-on funding led by Blume Ventures.
Led by TCS Remote Energy Management Solution, Zenatix, Ecolibrium Energy, Zenatix, 6th Energy Technologies and Connectum are some of the companies that provide IoT-enabled energy solutions for buildings, energy companies and distribution networks.
According to a report, industries in India consume 45% of the 900 Bn units of power produced. 35% of the electric power produced is lost, and the losses are due to transmission and distribution (16%) inefficiencies, theft (10%) and inefficiencies among users (10%).
Given that India is one of the 191 countries to have signed the Paris Climate Change Agreement and unlike the US, has committed to improving its energy affairs, Zenatix has a huge market with limited challenge and competition.
Ecolibrium Energy
Founded in 2011 by Chintan Soni and Harit Soni, Ahmedabad-based Ecolibrium Energy provides energy intelligence to commercial and industrial consumers and utilities. The startup’s big data analytics platform intends to improve operational efficiency by optimising energy usage and asset utilisation.
Ecolibrium Energy Fact Sheet
The startup helps power distribution companies meet their demand-side management goals. SmartSense connects with their high power consuming consumers and helps them optimise the way they consume power.
It provides targeted energy analytics to clients in a wide variety of sectors such as pharmaceuticals, engineering and FMCGs. Some big names include Coca-Cola, Delhi Metro Rail Corp, Intas Pharma, and Fiat.
In July this year, Ecolibrium Energy had raised $2.6 Mn (INR 18 Cr) in funding from Infuse Ventures Inc, JLL Technology Ventures and an anonymous angel investor. With the investments, the IoT startup eyes to create a global presence and also enhance customer engagement. A portion of the funds is also being used to develop advanced deep machine learning algorithms to ensure better performance of electrical equipment.
While India is the third largest energy producer in the world, Ecolibrium Energy has a huge untapped energy market to cater to.
Smartron
Founded by Mahesh Lingareddy, ex-Intel and co-founder of Silicon Valley startup Soft Machines, along with Narsi Reddy and Rohit Rathi in 2014, Smartron India provides an intelligent connected platform TronX, offering highly customised and personalised experiences, services and care through the next generation of smart devices across various IoT verticals.
Smartron Fact Sheet
TronX allows one to interact and control various devices at home from TV, appliances, lights, ACs to doors and windows through touch or voice or gestures. TronX enables intelligent and customised experiences, ranging from entertainment to shopping to security to energy management to climate control.
Trying to compete with Chinese tech giant Xiaomi in the global market, the startup had raised over $40 Mn in funding this year from some sovereign funds in the Middle East, investors from the US and corporate investors.
Sachin Tendulkar is one of its key strategic shareholders and brand ambassador. The IoT startup had raised an undisclosed amount of funding from Sanjay Jha, CEO of GlobalFoundries.
Recently, the company announced an acquisition in the home automation space for $10 Mn (INR 6.4 Cr). Post the acquisition, MiQasa has been brought under the banner of Smartron and has been rebranded as TronX Things. The move is aimed at enriching Smartron’s IoT platform. The company has also announced its plans to invest another $10 Mn in logistics and sales and distribution network.
Smartron is one of the few Indian mobile and other IoT device manufacturers that aim to cater to the global consumers.
Carsense
Founded by IITians Rohan Vadgaonkar, Pushkar Limaye, Urmil Shah and Prathamesh Joshi in 2015, Mumbai-based CarSense, earlier known as Carnot, is an IoT startup offering a car diagnostic solutions.
Besides their existing car diagnostic solution, the company is now also positioning itself in the space of car security by deploying GPS, accelerometer, gyroscope and Bluetooth.
Carsense Fact Sheet
CarSense plugs into the OBD Port, while its easy-to-use software app ensures whether the electronic systems inside a user’s car (in modern cars, everything comes under electronic systems) is in working order. Once integrated into the system, it can be used to monitor the car to ensure its safety, send alert signals in case repairs are required, give insights on the car’s fuel economy and more.
CarSense is among the early entrants in the car diagnostic solution space, which is estimated at $31.5 Bn globally. Having listed its products on several ecommerce platforms such as Amazon and Techatron, the startup claims to have a success revenue and profitable model.
At present, the $100K Qualcomm Design India challenge winner has a few competitors such as Actia India, iWave and Ampro testing. Most of the companies in the Indian market are suppliers. Carsense with an offering at as low as $100 clearly can count on its edge.
Covacsis Technologies
Founded by Tarun Mishra and Abhijeet Mhatre in 2009, Covacsis Technologies is an IoT-based startup that has conceptualised, designed and implemented a technology framework to optimise the operational and financial efficiency of a factory in real time. The technology combines IoT and the levers of Industry 4.0.
Covacsis Technologies Fact Sheet
The startup offers tailor-made analytics suite for manufacturing operations. Using machine learning and big data technologies, it offers highly dynamic decision-making capabilities in real time. The Intelligent Plant Framework from Covacsis provides a 360° visibility of the manufacturing floor in real time.
Covacsis helps evaluate the sustainable economics of the shop floor, for a variety of departments across the organisation. The flagship solution IPF is widely used by manufacturing companies across sectors textile, pharma, cement, steel, auto, FMCG, packaging, chemical and renewable energy.
With the government having committed over $100 Bn investments towards creating 100 smart cities as well as Delhi-Mumbai corridors, there will be an exponential rise in demand for shop floor mechanism solutions in the country. And, Covacsis claims to be the first Indian company in this space.
Though there are a number of companies such SAP India, InTouch Systems, RICOH, and Inventrax, which provide MES software solutions in India, considering the market size, Covacsis does have a shot to claim the leading position.
In 2014, the company had raised $3 Mn in Series B funding from GenNext Ventures and Blume Ventures, taking its total funding to $3.5 Mn.
AerX labs
Founded by Sumit Rishi, Kartavya Mohan Gupta and Priyank Sharma in 2015, AerX Labs is Bengaluru based avionics/flight simulation startup that makes professional-grade certifiable simulators for airlines, flight Schools, universities and corporates. The startup is currently working on connected simulators and deep learning to assess risk behaviours for pilot training and mixed reality to disrupt the space for innovative and cost competitive simulation.
Incubated by Intel India and Bosch India, it has an installation base of 40+ products including 18 simulators across all segments of customers, claims the company.
AerX labs Fact Sheet
Originally started with a single engine simulator, the IoT startup has now moved to multi-engine and fixed-base simulators. which are used by airlines for early-stage pilot training. The startup now aims to build full-flight simulators, which cost upwards of $12.5 Mn (INR 80 Cr) and are used in advanced pilot training.
The startup offers simulator rentals, in addition to maintenance, upgrade and training services as part of its design consultancy offerings.The simulators that available for rentals are accompanied by DGCA licensed flight instructors, for short and long-term uses, ranging from a few hours to days.
Amid tough competition from other players like CAE Simulation Training, Flightrix, Aviacom, Ray Dynamics and PCI India, AerX Labs can count on its incubators Intel India and SINE IITB as enablers, while sealing deals with Indian airlines companies.
TerraBlue XT
Founded by Rajlakshmi Borthakur in 2015, TerraBlue XT is building a complete health ecosystem for the benefit of people worldwide, connecting patients, caregivers, doctors and hospitals with a common thread.
The Bengaluru-based startup has come up with solutions called TJay and Xaant. While TJay, an innovative solution for the prediction and management of epilepsy, is more about unravelling the mysteries of the brain, Xaant is a therapeutic wearable device that traces the inner realm of a mind’s pathways to generate real-time data when one is trying out any method to calm his/her senses.
TerraBlue XT Fact Sheet
The company has received funding from Idea2PoC and Intel India Maker Lab.
While CEO and founder Rajlakshmi Borthakur has been recognised as one of the 12 “women transforming India” by NITI Aayog, the UN and MyGov, her startup TerraBlue XT is also one of the winners of a national innovation challenge 2016 and the Acer Award for Innovation at the APEC O2O Summit, Taiwan in 2016.
Backed by the Government of India’s Department of BioTech, the Karnataka government’s Dept. of ITBT, neDFI, birac, and the IIM Ahmedabad Entrepreneurship Cell, the startup is all set to disrupt the Indian IoT sector.
Bharti Robotic Systems
Founded by Debashis Das in 2015, Pune-based Bharati Robotics aims to accelerate the application of IoT-based robotic solutions in cleaning and material handling equipment such as scrubber-driers and sweepers.
Bharti Robotic Systems Fact Sheet
IoT-enabled solutions in cleaning and hygiene has been the forte of big foreign players like Sealed Air, Karcher, IPC, and Nilfisk. Sealed Air has already acquired the USA’s leading robotics brand Intellibot and has introduced Internet of Clean across a range of cleaning equipment and hygiene products. Nilfisk too has joined hands with Carnegie Robotics to provide nextGen cleaning solutions.
Incubated at Intel India Makers Lab, Bharti Robotics has developed an indigenous scrubber-drier as well as a material handling machine based on IoT. The startup recently raised an undisclosed amount of funding from its existing investors – Society For Innovation and Entrepreneurship (SINE, IIT Bombay Incubator), and other angel investors. The raised fund will be used to expand the manufacturing capacity and technology applicability and cater to demand from both local and global customers.
Hug Innovations
Founded by Raj Shekhar Neravati in 2014, Hyderabad-based Hug Innovations offers an IoT wearable Hug Smartwatch that employs gesture control for various activities like playing music and so forth. The smartwatch tracks users’ food intake, water intake along with different activities performed throughout the day. Its nutrition dashboard gives the total calories burnt for the day.
Hug Innovations Fact Sheet
The smartwatch has an SOS button which could be pressed into danger. This will send an immediate message and help family and friends to live track the location. Interestingly, the watch has customised maps to guide the user to the nearest hospitals and police stations. The product basically provides users access to different kind of emergency services that they can avail in case their family and well-wishers are not available.
For the past few years, a lot of new startups have come up with IoT-enabled wearable devices. Startups that are catering to the wearable IoT space are Actofit, Boltt, Getactive, Goqii, and so on. However, Hug Innovations is offering one of the lightest smartwatches powered with gesture controls, remote capture and SOS button.
The startup has the potential to disrupt the space, provided it continues to innovate. With Titan having invested $5 Mn in wearable IoT firm CoveIoT, the corporate eye is already on these wearable IoT startups. In June 2017, Hug Innovations had raised $5 Mn in Series A funding round during a live instant funding event organised by TiE Hyderabad – The Guardian Angel.
Cyclops Medtech
Founded in 2015 by Niranjan Subbarao, Srinivas Dorasala, and Ravi Nayar, Cyclops Medtech is a medtech startup working on vestibular, surgical and eye-tracking solutions for the masses. The company was conceived with the idea of developing a vertigo diagnostic device at an affordable cost.
Its cutting-edge, complete balance assessment platform Cyclops BalanceEye is an assessment tool that encompasses hardware, software, and machine learning modules on the Cloud.
Cyclops Medtech Fact Sheet
Their first product, a “complete balance assessment tool”, is a wearable clinical device used to diagnose vertigo. The device has already been tested at a leading ENT centre in Bengaluru for over six months.
The company was incubated at the BioMedical Innovation Centre at BMS College of Engineering, Bengaluru.
The winner of the NASSCOM Emerge 50 Awards, Cyclops Medtech is a Bengaluru-based startup that aims to create innovative and cost-effective medical technology and devices, which can dramatically expand the scope of diagnosis and thereby aid in faster and better cure.
Taking into consideration factors like funding status, market spaces, ideas and innovations, founders’ background and scalability, these startups might lead the legion of 971 Indian IoT startups in the new future.
However, the Indian startup ecosystem is certainly not like the Valley, where merely performance attracts funding; but instead, it is still much like the traditional one with some refinements where for a startup survival between the two funding itself is assumed to be a big achievement.
While the future largely counts on the marrying IoT, deeptech with ML, AI and big data analytics, and given that IoT still has low penetration in the Indian market, definitely a big untapped market for IoT startups which are able to customise their services in accordance with the local demand.
*Market figures are debatable as different market research firms have predicted drastically different figures.
While these were the Indian IoT startups to watch out for in 2018, stay tuned for next edition of Startup Watchlist, where we will be featuring HealthTech startups to watch out for in 2018, click here for more stories!
[The startups mentioned above have been selected on editorial discretion, our interactions with the startups and other industry veterans.]
AerX Labs Bharti Robotics Carnot CarSense Covacsis Technologies Cyclops Medtech Ecolibrium Energy Hug Innovations Indian IoT Startups IoT IoT Startups Smartron Startup Watchlist Startups Startups To Watch Stellapps TerraBlue XT Zenatix Zenatix solutions
An Electronics Engineer turned Business Journalist | Blogger | Avid Reader. Previously associated with Network18, Clean India Journal and Mudra Communications, he has been writing on a variety of issues that include cryptocurrency, policy-related matters, blockchain, investments-destination, technology and other startup-related matters.
https://inc42.com/features/watchlist-healthtech-startups-2018/
https://inc42.com/features/2017-review-indian-startup-ecosystem/
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PUT OUT THAT LIGHT!
Posted by Julian Flood | Jul 20, 2019 | Debate | 6 |
“Men, it has been well said, think in herds; it will be seen that they go mad in herds, while they only recover their senses slowly, one by one.”
Charles MacKay, Extraordinary Popular Delusions and the Madness of Crowds
A couple of years back we had a winter that went on and on, dragged through a cold dark February, a dull, still March, a cold, dark and still April. Those on oil central heating cursed the darkness and ordered more from their supplier. Those lucky enough to be on the gas grid turned up the thermostat and worried about the bill. Those on electrical heating shivered because they didn’t want to be bankrupted.
The UK was down to two weeks supply of natural gas, the gas used by the combined cycle power stations that are the basis of our electrical supply. Without a top-up the lights would have gone out. Without energy – and when the clouds gather and the winds drop that means hydrocarbon energy – everything stops. Cars. Lights. Hearts.
A car is made only incidentally of steel. The brain of the man who manipulates the computer controlling the production line is made only incidentally of food. The computer chip in this computer on which I type this is made only incidentally of silicon. All of them are made of energy, and chiefly in our civilisation they are made of electrical energy. Electricity drives the line, grows the food, powers the foundries, pumps the water and clears the sewage. And electricity is primarily, overwhelmingly made by the combustion of hydrocarbons.
If some invading alien were to power down the electrical Grid then our civilisation would descend into chaos in days.
Let me introduce you to that composite alien, the multi-bodied creature that has for the last eleven years been working tirelessly to break the Grid, to turn off our lights, close our factories and kill hundreds of thousands of our people in inadequately-heated winter homes. These are the Secretaries of State for Energy and Climate Change:
Ed Milliband. PPE Corpus Christi Oxford. MSc LSE in economics. Straight into politics after completing his degrees, initially in television then as a bag carrier to various Labour grandees. Science background, nil. Industry nil. Practical world experience nil.
Chris Huhne. PPE Magdalen College Oxford. Worked in the City and financial journalism. Science background nil, unless you count economics. Which I don’t.
Ed Davey. PPE Jesus College Oxford. MSc Birkbeck College London in economics. Economics policy developer for the LibDems. Industry experience: worked in a pork pie factory as a teenager. Was sufficiently aware of the need for reliable energy to advocate exploitation of UK shale gas.
Amber Rudd. History, Edinburgh. Various jobs in financial management, apparently thanks to family contacts, without conspicuous success. Contact with the real world as aristocracy coordinator for Four Weddings and a Funeral.
In 2016 the role was taken over by the Department for Business, Energy and Industrial Strategy, the relevant minister being:
Greg Clarke. Economics, Magdalene College Cambridge.
Are we seeing a pattern here? Could that pattern be the reason that the UK is suicidally signing up to every crackpot decarbonisation scheme, wilfully ignoring the potential (and actual) costs of being a world leader in turning the lights out? That’s “world leader” as in first lemming over the cliff – I’d prefer to leave that to Germany which has jumped off the reliable energy generation cliff and is at the ‘it’s OK so far’ stage in the tumble to the rocks below.
The DNA of the renewable energy scam comes from City spivs crossed with a load of politicians who fancy themselves at the same game. Here’s what wiki says about energy CfDs:
“Contracts for Difference (CfD) are a system of reverse auctions intended to give investors the confidence and certainty they need to invest in low carbon electricity generation. CfDs have also been agreed on a bilateral basis, such as the agreement struck for the Hinkley Point C nuclear plant.
CfDs work by fixing the prices received by low carbon generation, reducing the risks they face, and ensuring that eligible technology receives a price for generated power that supports investment. CfDs also reduce costs by fixing the price consumers pay for low carbon electricity. This requires generators to pay money back when wholesale electricity prices are higher than the strike price, and provides financial support when the wholesale electricity prices are lower.
The costs of the CfD scheme are funded by a statutory levy on all UK-based licensed electricity suppliers (known as the ‘Supplier Obligation’), which is passed on to consumers.”
And now in English? It looks to me as if CfDs are just a fancy way of hiding the fact that big companies are allowed to build inadequate power schemes – inadequate because they give no guarantees for continuity of supply – and they will be paid top-whack regardless. In any market in the UK this is known as the ‘open your wallet and repeat after me ‘Help yourself’ agreement.
But it’s OK. After the market huckster has emptied your wallet, the great British public is forced to fill it up again – you did see that ‘which is passed on to consumers’? Who pays most? The old. The poor. The sick. The people who proportionately spend most on electricity. This is not just inefficient, unreliable and wasteful. It’s immoral.
We dodged the bullet in that cold dark spring. With two weeks to go, two Liquified Natural Gas carrier ships arrived from Qatar, with two weeks to go to the lights going out. That’s how close we were to a real emergency.
We got here by electing a lot of career politicians who wouldn’t know a Guy Fawkes rocket from a Saturn 5.
NextFreedom to say what you want and Freedom to do what you want – Part 1
Julian Flood
State of play: the score so far. Part I
An Ex-Pat in France about BREXIT
Do we need a revolution in UK politics? Part 2
Electoral Reform (Stage 1), SAGE, the Party and Co-operation – Part 2.
Michael Keal on July 21, 2019 at 4:48 pm
The trouble with the precautionary principle as it’s currently being applied in the context of global warming (and notice I didn’t say ‘climate change’, I believe in holding their feet to the fire) is that THERE ARE RISKS BOTH WAYS.
Here in the UK and most Western countries, especially really cold places like Canada, being able to keep warm in the winter is a matter of life and death, potentially for large numbers of people.
Therefore, blowing up a perfectly good, working power stations in the UK was sheer madness.
Fair enough, I understand that if members of Britain’s current parliament fervently believe the prognostications emanating from big Al Gore and the boys at the IPCC then shutting down East Tilbury power station could be construed as taking a reasonable precaution allowing us to wait for ANOTHER 30 years, to see if temperature actually do rise as predicted. BUT BLOWING IT UP???
We know from palaeontology that there IS no tipping point beyond which temperatures on Earth would rise rapidly without stopping and the ‘Earth would catch fire’. Simple physics, there isn’t enough energy in the system to make this possible. Poor old Sol’s keeping us just about as warm as it can, thank you very much! That also knocks out catastrophic sea level rise. Some years ago, when big Al first began preaching the climate gospel, Justice Burton, in a UK court case, ruled against arguments suggesting rapid, catastrophic sea-level rise caused by global warming saying that even if it were possible it would take thousands of years for all the ice on Greenland to melt with the Energy from the Sun. (He didn’t even bother mentioning the 2.8 km thick ice sheet at the South Pole!)
In addition, we now have an understanding of the mechanism which limits sea temperatures in the tropical oceans. When the sea temperatures in the Pacific reach about 28 deg C, thunderstorms spontaneously form. These transport heat to stratosphere where it is lost to space. This limits sea temperatures there to about 31 deg. C.
https://wattsupwiththat.wordpress.com/2012/02/12/argo-and-the-ocean-temperature-maximum/
Let’s face facts. Global Warming isn’t happening. We need to begin doing what Communist China and most developing countries are already doing and begin building coal power stations hand-over-fist because they deliver power much more cheaply than the alternatives. STARTING IN EAST TILBURY.
And Hinkley should be cancelled with immediate effect.
terry sullivan on July 21, 2019 at 8:22 am
co2 is not a problem
Too many have made and continue to make a great deal of money from the climate change scam. That is why it will be difficult to stop.
sonyaporter on July 20, 2019 at 2:00 pm
May I suggest that we all keep tabs on the following web site: http://www.iceagenow.info ? The world’s climate goes up and down in cycles and while, yes, we do have to cope with the pollution that an ever-increasing world population creates, we may be facing another Maunder Minimum or Mini-Ice Age and shall have to cope with that rather than Global Warming. Rather than a top-down site where someone tells us what is likely to happen in the near future, this site consists of information the readers send in about what his happening at present in their own parts of the world, and what is happening now looks remarkably cool…
Scroll through a couple of pages and see what you think.
Michael Keal on July 20, 2019 at 10:25 am
One thing to note. On my Vaillant boiler if the electricity goes down it stops working. I presume this would apply to other modern boilers. So unless one has a gas fireplace or a fireplace to burn wood, coal or furniture one could be in trouble. If it freezes indoors pipes will burst. Lots of them all at once if it’s widespread.
I have some -20 deg C sleeping bags. Those bar-stewards in charge aren’t going to get me!
We’ve been at the bottom of the current very low solar cycle for quite some time. it seems likely that probability of unusually cold weather in the UK as occurred during the Maunder Minimum in the 1700’s and occurred last winter in Canada and parts of the US is increasing.
Julian Flood on July 20, 2019 at 5:17 pm
Michael, the trouble is that the science isn’t settled either way. My hunch is that it’s not going to warm fast enough to bet the farm on cutting CO2 at an emergency rate, but I’m not sure. I have a hunch that CO2 is not the cause of what warming there is (half the rate the models say and on which the silly talk of climate crisis and climate emergency is predicated) but I’d like to have a route to safety if it turns out I’m wrong.
Precautionary preparation will be comparatively cheap, and if we spend our money wisely — SMR reactor design, a couple of Latham and Salter’s cloud ships — then we will be ready for climate crisis, and we’ll have saleable technology to help dry countries make rain and poor countries make electricity if it turns out that climate emergency is a load of hysterical dingo kidneys.
If it starts to cool we’re in trouble. SMRs will help, but maybe we should look for some way of heating houses cheaply and without spending too much foreign exchange. Gas would be nice…
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« Dravidian liars and anti-Hindu atheists
Tehelka video mixing and sound recording of horror and terror! »
Romila Thapar, Duke University, Methodist Church or Romila Thapar, Secularism, Secular history: The Role of Historian and Social Change!
Published on October 23rd, 2007 In Uncategorized, Politics | Views 410
Romila Thapar, Duke University, Methodist Church orRomila Thapar, Secularism, Secular history: The Role of Historian and Social Change! I am happy to know that, “The Historian in the World: A Conversation with John Hope Franklin and Romila Thapar” will take place at 3 p.m. in the Divinity School’s Goodson Chapel on Duke’s West Campus. It is free and open to the public. Srinivas Aravamudan, director of the John Hope Franklin Humanities Institute, will moderate the discussion”. http://www.dukenews .duke.edu/ 2007/10/conversa tion.htmlI am more anxious what the historians discuss there in the Divinity School’s Goodson Chapel on Duke’s West Campus on October 22, 2007!
“the DivinitySchool’s Goodson Chapel on Duke’s West Campus” made me curious to look into the details. The University claims that, “The Duke University is related the Methodist Church”.
For details see: “Duke University”s Relation to the Methodist Church”: http://library.duke.edu/uarchives/history/duke-umchh.html
Well, it is all right, bt how the reportedly Communist or Marxist, progressive, secuar Romila Thapar would be speaking there in the, “the Divinity School’s Goodson Chapel on Duke’s West Campus”?
How “Two distinguished scholars will share their views of the role of the historian and social change”?
Would they discuss within the Charter, bylaws, aims, and mission statement” or they go beyond?
The “Charter, bylaws, aims, and mission statement” contains a provision, as follows:
“The aims of Duke University are to assert a faith in the eternal union of knowledge and religion set forth in the teachings and character of Jesus Christ, the Son of God; to advance learning in all lines of truth; to defend scholarship against all false notions and ideals; to develop a Christian love of freedom and truth; to promote a sincere spirit of tolerance; to discourage all partisan and sectarian strife; and to render the largest permanent service to the individual, the state, the nation, and the church. Unto these ends shall the affairs of this University always be administered”.http://library.duke.edu/uarchives/history/charterlink.html
How Ropmila Thapar hailing from “Secular India” is going to be accommodative, conducive and recptive to such Christians principles in the name of Jesus Christ? This makes me remember as to how the Christian Crusades, marriages and other functions are held at the “Periyar Tidal” (auditourium with big hall) at Chennai, India. The podium / stage there bear the Cross-believing Christians and the atheists, who speak against the God, scriptures and believers! Like that, would the “the Divinity School’s Goodson Chapel on Duke’s West Campus” bear the secular, progressive and sectarian Romila Thapar there in the name of Jesus Christ, the Son of God?
Just remember, what she wrote about Jesus Christ, when she was accusing Rama, the Hindu God as a myth:
“This does not happen with the biographies of those who were known to be historical figures and who founded belief systems: the Buddha, Jesus Christ, Mohammad. Their biographies adhere largely to a single story-line and this helps to endorse the ‘official’ narrative of their life. Their existence is recorded in other sources as well that are not just narratives of their lives but have diverse associations…..”.
At that time, I had responded as follows:
Their biographies adhere largely to a single story-line and this helps to endorse the ‘official’ narrative of their life.Why they should largely adhere to a single line? How this helps “official” narrative? How “official” it could be of “their life”? Why can’t you write as a historian instead of believer here? That the “biographers” were compelled or forced to accept or adhere to a single line proves that many lines were left out. And still small number of biographers who did not adhere to a single line is also exposed. Then, what you are talking about? Majority view and minority view? Condemn the “lesser” and accept or approve the Larger”! Adhere to one-line and forget many lines! What sort of historian you are? That man Karu has become a senile man and talks differently. Do you also do the same think as a senile lady?How you endorse such one-liners? Is there any historical methodology to that effect? Which University teaches such approving of one-line biography by eminent historians like you?Do not fool Indians. Ernest Renan, J. M. Robertson and so many reputed authorities are there on the subject matter of Jesus Christ and Christianity. Any way, it is your cowardice gets exposed, as you never whispered anything, when there was much Christian opposition to screening of “Da Vinci Code”. However, when the so-called “Hindutva judgment” came out, you vociferously jumped and asserted that “We would go to Court”. Everything appeared in “the Hindu” itself with your face. Madam, what happened? But now you come siding with atheists, anti-Hindus, anti-nationals as a historian suppressing the recent past and forgetting your own past!
Their existence is recorded in other sources as well that are not just narratives of their lives but have diverse associations. So also Rama. Why then your argument goes differently.In fact, their associations differ. But, Ramayana core story, as H. D. Sankalia in his “Ramayana Myth or Reality” that it had been there nearly for 3000 years.How “That their existences is recorded in other sources” help you to decide?
It may be noted that historians and scholars have pointed out that Christ story was copied from
Krishna! Rama was repeatedly mentioned in different literature not because of variance, but influence and impact created on the people well before 2500-3000 YBP. Was the Sangam poet a fool to record in his poem about his discussion with his army about the mode of crossing over the ocean to Lanka”. How that poet was imaging that that Lanka should have been the Lanka of Ramayana in his times i.e, 2500 – 3000 YBP?”
Definitely, the Americans and American Christian believers might be knowing about the background and the implications revoving around the discussion. So, we Indians are eagerly waiting to see as to how tshe is going to discuss within the conditions of the University and Christian belief system or she would have courage to vent our her genuine feeling as sjhe has been doing here in India against Hindus. As she has recently started supporting the atheist political party DK-DMK-PMK combine of the ruling combine (supported by the Communist-Marxist political parties from outside), we look forward the discussion to fulfil the following conditions:
The aims of Duke University are to assert a faith in the eternal union of knowledge and religion set forth in the teachings and character of Jesus Christ, the Son of God; V to advance learning in all lines of truth; to defend scholarship against all false notions and ideals; to develop a Christian love of freedom and truth; V to promote a sincere spirit of tolerance; to discourage all partisan and sectarian strife; and V to render the largest permanent service to the individual, the state, the nation, and the church.
Unto these ends shall the affairs of this University always be administered
The activities of Duke foundation have been obviously Christian:
For details: click and see http://www.dukeendowment.org/ruralchurch
22-10-2007.
Tags: Chennai, DivinitySchool, Duke University, India, J. M. Robertson, John Hope Franklin, Romila Thapar, Srinivas Aravamudan
This entry was posted on July 16, 2009 at 11:48 am and is filed under Ayodhya, bible, Christ, Christian Reformed Church, christology, chronology, Divinity, Duke University, historicism, historicity, historiography, J. M. Robertson, Jesus Christ, Romila Thapar, theology. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
2 Responses to “Romila Thapar, Duke University, Methodist Church or Romila Thapar, Secularism, Secular history: The Role of Historian and Social Change!”
vedaprakash Says:
1. MNachiappan Says:
Posted on October 23rd, 2007
America has been the highly developed country and I am surprised that the Universities there are funded by Christian institutions.
Even if they are funded, I am more surprised to know that they have to work according to Jesus Christ and so on, as the bylaws assert:
1. “The aims of Duke University are to assert a faith in the eternal union of knowledge and religion set forth in the teachings and character of Jesus Christ, the Son of God;
How the secular, advanced Americans studying in the University would be asserting “a faith in the eternal union of knowledge and religion set forth in the teachings and character of Jesus Christ, the Son of God”? Could all the subjects be according to such aims?
2. to advance learning in all lines of truth;
Perhaps, it would be some sort of “Christian science”, Christian physics, Christian biology like that?
3. to defend scholarship against all false notions and ideals;
So they would be taught to hate all non-Christian religions? How Romila Thapar and Arvamuthan would react to the situation. The latter appear to be a Tamil man. How he would react to such theological set-up?
4. to develop a Christian love of freedom and truth;
So naturally, other religions can have no place.
5. to promote a sincere spirit of tolerance;
Whether such spirit would be only for Christians or for all?
6. to discourage all partisan and sectarian strife; and
As believers of Jesus Christ ad members of Methodist Church, how they would accommodate others? By the how such sectarian strife etc., would be existing in America. We Indians think that USA have been paradise on the earth and all Americans would be enjoying like anything and so on! Let us see how our Romila Thapar solves the problem.
7. to render the largest permanent service to the individual, the state, the nation, and the church. Unto these ends shall the affairs of this University always be administered”.
We have to get the full discussion of the both the Historians with moderator’s coments, so that it would be very interesting to Indians.
M. Nachiappan.
2. gsuresh Says:
M. Nachiappan: “America has been the highly developed country and I am surprised that the Universities there are funded by Christian institutions.”
Except University of South Carolina, all other major universities in US are founded by christian missionaries…..Isn’t more surprising?
Definitely, it is news for me.
I am under the impression that the Americans would be totally secular.
In India also, some Universities are owned by “Hindus”, but they never act as “Hindus”. In fact, they do not have such feeling or sense of “Hindus”.
Sometime back, during the Tamilnadu History Congress held at Mayiladurai, the Mutt head, who was invited to inaugurate the Session, spoke something about the antiquity of India, the fallacy of historical hypotheses about Aryans, Dravidians etc. Though, all were listening to him with interest, when the General secretary or President of TNHC, one Jagadesan proceeded the Swamiji to talk. He started refuting him! This is pointed out to show how much freedom is given to the so-called Historians in India even talk against the authority.
But I do not know, whether the same historians go there would or could speak against the Church, Christianity, Christian God etc., as they used to do here.
How then, the History professors, lecturers or historians, as they are used to mentioned as work under such Universities? Naturally aiding and abetting the Church or obliging and faithfully carrying out what the Church wants to do?
Is it not?
Mr. Vedaprakash,
There should be a correction in your posting.
The meeting is to be held on October 27 and not as you mentioned,”I am more anxious what the historians discuss there in the Divinity School’s Goodson Chapel on Duke’s West Campus on October 22, 2007!”
M. Nachiappan
Posted on November 1st, 2007
October 27, 2007 has gone!
What happened to her speech?
Whether “The Hindu” or Economic and Political weekly has published it or not?
Jesus Christ a historical figure? Well, visit jesusneverexisted.com
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Fibroblast Primary Cilia Are Required for Cardiac Fibrosis
Elisa Villalobos, Alfredo Criollo, Gabriele G. Schiattarella, Francisco Altamirano, Kristin M. French, Herman I. May, Nan Jiang, Ngoc Uyen Nhi Nguyen, Diego Romero, Juan Carlos Roa, Lorena García, Guillermo Diaz-Araya, Eugenia Morselli, Anwarul Ferdous, Simon Conway, Hesham A. Sadek, Thomas G. Gillette, Sergio Lavandero, Joseph A. Hill
Cardiac Developmental Biology
BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have been described in developing heart, a role for primary cilia in adult heart has not been reported. This, coupled with the fact that mutations in genes coding for multiple ciliary proteins underlie polycystic kidney disease, a disorder with numerous cardiovascular manifestations, prompted us to identify cells in adult heart harboring a primary cilium and to determine whether primary cilia play a role in disease-related remodeling. METHODS: Histological analysis of cardiac tissues from C57BL/6 mouse embryos, neonatal mice, and adult mice was performed to evaluate for primary cilia. Three injury models (apical resection, ischemia/reperfusion, and myocardial infarction) were used to identify the location and cell type of ciliated cells with the use of antibodies specific for cilia (acetylated tubulin, γ-tubulin, polycystin [PC] 1, PC2, and KIF3A), fibroblasts (vimentin, α-smooth muscle actin, and fibroblast-specific protein-1), and cardiomyocytes (α-actinin and troponin I). A similar approach was used to assess for primary cilia in infarcted human myocardial tissue. We studied mice silenced exclusively in myofibroblasts for PC1 and evaluated the role of PC1 in fibrogenesis in adult rat fibroblasts and myofibroblasts. RESULTS: We identified primary cilia in mouse, rat, and human heart, specifically and exclusively in cardiac fibroblasts. Ciliated fibroblasts are enriched in areas of myocardial injury. Transforming growth factor β-1 signaling and SMAD3 activation were impaired in fibroblasts depleted of the primary cilium. Extracellular matrix protein levels and contractile function were also impaired. In vivo, depletion of PC1 in activated fibroblasts after myocardial infarction impaired the remodeling response. CONCLUSIONS: Fibroblasts in the neonatal and adult heart harbor a primary cilium. This organelle and its requisite signaling protein, PC1, are required for critical elements of fibrogenesis, including transforming growth factor β-1-SMAD3 activation, production of extracellular matrix proteins, and cell contractility. Together, these findings point to a pivotal role of this organelle, and PC1, in disease-related pathological cardiac remodeling and suggest that some of the cardiovascular manifestations of autosomal dominant polycystic kidney disease derive directly from myocardium-autonomous abnormalities.
Published - May 14 2019
Myofibroblasts
Transforming Growth Factors
Actinin
Autosomal Dominant Polycystic Kidney
Polycystic Kidney Diseases
Troponin I
Cellular Structures
Inbred C57BL Mouse
Reperfusion
PKD1 protein
TGF-beta
Villalobos, E., Criollo, A., Schiattarella, G. G., Altamirano, F., French, K. M., May, H. I., ... Hill, J. A. (2019). Fibroblast Primary Cilia Are Required for Cardiac Fibrosis. Circulation, 139(20), 2342-2357. https://doi.org/10.1161/CIRCULATIONAHA.117.028752
Fibroblast Primary Cilia Are Required for Cardiac Fibrosis. / Villalobos, Elisa; Criollo, Alfredo; Schiattarella, Gabriele G.; Altamirano, Francisco; French, Kristin M.; May, Herman I.; Jiang, Nan; Nguyen, Ngoc Uyen Nhi; Romero, Diego; Roa, Juan Carlos; García, Lorena; Diaz-Araya, Guillermo; Morselli, Eugenia; Ferdous, Anwarul; Conway, Simon; Sadek, Hesham A.; Gillette, Thomas G.; Lavandero, Sergio; Hill, Joseph A.
In: Circulation, Vol. 139, No. 20, 14.05.2019, p. 2342-2357.
Villalobos, E, Criollo, A, Schiattarella, GG, Altamirano, F, French, KM, May, HI, Jiang, N, Nguyen, NUN, Romero, D, Roa, JC, García, L, Diaz-Araya, G, Morselli, E, Ferdous, A, Conway, S, Sadek, HA, Gillette, TG, Lavandero, S & Hill, JA 2019, 'Fibroblast Primary Cilia Are Required for Cardiac Fibrosis', Circulation, vol. 139, no. 20, pp. 2342-2357. https://doi.org/10.1161/CIRCULATIONAHA.117.028752
Villalobos E, Criollo A, Schiattarella GG, Altamirano F, French KM, May HI et al. Fibroblast Primary Cilia Are Required for Cardiac Fibrosis. Circulation. 2019 May 14;139(20):2342-2357. https://doi.org/10.1161/CIRCULATIONAHA.117.028752
Villalobos, Elisa ; Criollo, Alfredo ; Schiattarella, Gabriele G. ; Altamirano, Francisco ; French, Kristin M. ; May, Herman I. ; Jiang, Nan ; Nguyen, Ngoc Uyen Nhi ; Romero, Diego ; Roa, Juan Carlos ; García, Lorena ; Diaz-Araya, Guillermo ; Morselli, Eugenia ; Ferdous, Anwarul ; Conway, Simon ; Sadek, Hesham A. ; Gillette, Thomas G. ; Lavandero, Sergio ; Hill, Joseph A. / Fibroblast Primary Cilia Are Required for Cardiac Fibrosis. In: Circulation. 2019 ; Vol. 139, No. 20. pp. 2342-2357.
@article{790415832dcd4088942cc5cadf672f49,
title = "Fibroblast Primary Cilia Are Required for Cardiac Fibrosis",
abstract = "BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have been described in developing heart, a role for primary cilia in adult heart has not been reported. This, coupled with the fact that mutations in genes coding for multiple ciliary proteins underlie polycystic kidney disease, a disorder with numerous cardiovascular manifestations, prompted us to identify cells in adult heart harboring a primary cilium and to determine whether primary cilia play a role in disease-related remodeling. METHODS: Histological analysis of cardiac tissues from C57BL/6 mouse embryos, neonatal mice, and adult mice was performed to evaluate for primary cilia. Three injury models (apical resection, ischemia/reperfusion, and myocardial infarction) were used to identify the location and cell type of ciliated cells with the use of antibodies specific for cilia (acetylated tubulin, γ-tubulin, polycystin [PC] 1, PC2, and KIF3A), fibroblasts (vimentin, α-smooth muscle actin, and fibroblast-specific protein-1), and cardiomyocytes (α-actinin and troponin I). A similar approach was used to assess for primary cilia in infarcted human myocardial tissue. We studied mice silenced exclusively in myofibroblasts for PC1 and evaluated the role of PC1 in fibrogenesis in adult rat fibroblasts and myofibroblasts. RESULTS: We identified primary cilia in mouse, rat, and human heart, specifically and exclusively in cardiac fibroblasts. Ciliated fibroblasts are enriched in areas of myocardial injury. Transforming growth factor β-1 signaling and SMAD3 activation were impaired in fibroblasts depleted of the primary cilium. Extracellular matrix protein levels and contractile function were also impaired. In vivo, depletion of PC1 in activated fibroblasts after myocardial infarction impaired the remodeling response. CONCLUSIONS: Fibroblasts in the neonatal and adult heart harbor a primary cilium. This organelle and its requisite signaling protein, PC1, are required for critical elements of fibrogenesis, including transforming growth factor β-1-SMAD3 activation, production of extracellular matrix proteins, and cell contractility. Together, these findings point to a pivotal role of this organelle, and PC1, in disease-related pathological cardiac remodeling and suggest that some of the cardiovascular manifestations of autosomal dominant polycystic kidney disease derive directly from myocardium-autonomous abnormalities.",
keywords = "cilia, fibroblasts, fibrosis, myocardial infarction, PKD1 protein, TGF-beta",
author = "Elisa Villalobos and Alfredo Criollo and Schiattarella, {Gabriele G.} and Francisco Altamirano and French, {Kristin M.} and May, {Herman I.} and Nan Jiang and Nguyen, {Ngoc Uyen Nhi} and Diego Romero and Roa, {Juan Carlos} and Lorena Garc{\'i}a and Guillermo Diaz-Araya and Eugenia Morselli and Anwarul Ferdous and Simon Conway and Sadek, {Hesham A.} and Gillette, {Thomas G.} and Sergio Lavandero and Hill, {Joseph A.}",
T1 - Fibroblast Primary Cilia Are Required for Cardiac Fibrosis
AU - Villalobos, Elisa
AU - Criollo, Alfredo
AU - Schiattarella, Gabriele G.
AU - Altamirano, Francisco
AU - French, Kristin M.
AU - May, Herman I.
AU - Jiang, Nan
AU - Nguyen, Ngoc Uyen Nhi
AU - Romero, Diego
AU - Roa, Juan Carlos
AU - García, Lorena
AU - Diaz-Araya, Guillermo
AU - Morselli, Eugenia
AU - Ferdous, Anwarul
AU - Conway, Simon
AU - Lavandero, Sergio
N2 - BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have been described in developing heart, a role for primary cilia in adult heart has not been reported. This, coupled with the fact that mutations in genes coding for multiple ciliary proteins underlie polycystic kidney disease, a disorder with numerous cardiovascular manifestations, prompted us to identify cells in adult heart harboring a primary cilium and to determine whether primary cilia play a role in disease-related remodeling. METHODS: Histological analysis of cardiac tissues from C57BL/6 mouse embryos, neonatal mice, and adult mice was performed to evaluate for primary cilia. Three injury models (apical resection, ischemia/reperfusion, and myocardial infarction) were used to identify the location and cell type of ciliated cells with the use of antibodies specific for cilia (acetylated tubulin, γ-tubulin, polycystin [PC] 1, PC2, and KIF3A), fibroblasts (vimentin, α-smooth muscle actin, and fibroblast-specific protein-1), and cardiomyocytes (α-actinin and troponin I). A similar approach was used to assess for primary cilia in infarcted human myocardial tissue. We studied mice silenced exclusively in myofibroblasts for PC1 and evaluated the role of PC1 in fibrogenesis in adult rat fibroblasts and myofibroblasts. RESULTS: We identified primary cilia in mouse, rat, and human heart, specifically and exclusively in cardiac fibroblasts. Ciliated fibroblasts are enriched in areas of myocardial injury. Transforming growth factor β-1 signaling and SMAD3 activation were impaired in fibroblasts depleted of the primary cilium. Extracellular matrix protein levels and contractile function were also impaired. In vivo, depletion of PC1 in activated fibroblasts after myocardial infarction impaired the remodeling response. CONCLUSIONS: Fibroblasts in the neonatal and adult heart harbor a primary cilium. This organelle and its requisite signaling protein, PC1, are required for critical elements of fibrogenesis, including transforming growth factor β-1-SMAD3 activation, production of extracellular matrix proteins, and cell contractility. Together, these findings point to a pivotal role of this organelle, and PC1, in disease-related pathological cardiac remodeling and suggest that some of the cardiovascular manifestations of autosomal dominant polycystic kidney disease derive directly from myocardium-autonomous abnormalities.
AB - BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have been described in developing heart, a role for primary cilia in adult heart has not been reported. This, coupled with the fact that mutations in genes coding for multiple ciliary proteins underlie polycystic kidney disease, a disorder with numerous cardiovascular manifestations, prompted us to identify cells in adult heart harboring a primary cilium and to determine whether primary cilia play a role in disease-related remodeling. METHODS: Histological analysis of cardiac tissues from C57BL/6 mouse embryos, neonatal mice, and adult mice was performed to evaluate for primary cilia. Three injury models (apical resection, ischemia/reperfusion, and myocardial infarction) were used to identify the location and cell type of ciliated cells with the use of antibodies specific for cilia (acetylated tubulin, γ-tubulin, polycystin [PC] 1, PC2, and KIF3A), fibroblasts (vimentin, α-smooth muscle actin, and fibroblast-specific protein-1), and cardiomyocytes (α-actinin and troponin I). A similar approach was used to assess for primary cilia in infarcted human myocardial tissue. We studied mice silenced exclusively in myofibroblasts for PC1 and evaluated the role of PC1 in fibrogenesis in adult rat fibroblasts and myofibroblasts. RESULTS: We identified primary cilia in mouse, rat, and human heart, specifically and exclusively in cardiac fibroblasts. Ciliated fibroblasts are enriched in areas of myocardial injury. Transforming growth factor β-1 signaling and SMAD3 activation were impaired in fibroblasts depleted of the primary cilium. Extracellular matrix protein levels and contractile function were also impaired. In vivo, depletion of PC1 in activated fibroblasts after myocardial infarction impaired the remodeling response. CONCLUSIONS: Fibroblasts in the neonatal and adult heart harbor a primary cilium. This organelle and its requisite signaling protein, PC1, are required for critical elements of fibrogenesis, including transforming growth factor β-1-SMAD3 activation, production of extracellular matrix proteins, and cell contractility. Together, these findings point to a pivotal role of this organelle, and PC1, in disease-related pathological cardiac remodeling and suggest that some of the cardiovascular manifestations of autosomal dominant polycystic kidney disease derive directly from myocardium-autonomous abnormalities.
KW - cilia
KW - fibroblasts
KW - fibrosis
KW - PKD1 protein
KW - TGF-beta
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ACF Fall Discussion
vcuEvan
Location: Richmond VA
Post by vcuEvan » Sun Nov 07, 2010 6:47 am
NOTE FROM THE FORUMS MANAGEMENT: This thread may contain question specifics. Do not read this thread if you are playing at Oxford on 11/20.
First, thanks to everyone who submitted packets and to Carsten, Guy, Will, Dallas, and John for doing a good job editing. To everyone who attended: I hope you enjoyed the tournament, and if you have any feedback, feel free to post it here. The set is cleared, so you can go ahead and cite specific questions.
Evan Adams
VCU '11, UVA '14, NYU '15
Ondes Martenot
Location: Troy, N.Y.
Re: ACF Fall Discussion
Post by Ondes Martenot » Sun Nov 07, 2010 10:21 am
So, my biggest complaint from this set was no uniform sense of difficulty. There was one bonus of the form amino acid/peptide bond/collagen. I guess collagen was the hard part but seriously how can a bonus like this distinguish between teams of basically any level. At the same time, there was also a John Adams (composer) bonus with a hard part on Harmonium. I'm not the best music player but these two bonuses seem they were meant for two very different tournaments. There were a lot of cases of stuff like this happening which made this set frustrating at times.
If this set was say slightly easier or slightly harder than last year, I guess I wouldn't have a big concern. The problem was that there was no consistency.
Aaron Cohen, Bergen County Academies '08, RPI '12, NYU-???, NAQT writer, HSAPQ writer, PACE writer
The Toad to Wigan Pier
Post by The Toad to Wigan Pier » Sun Nov 07, 2010 10:35 am
Ondes Martenot wrote: So, my biggest complaint from this set was no uniform sense of difficulty. There was one bonus of the form amino acid/peptide bond/collagen. I guess collagen was the hard part but seriously how can a bonus like this distinguish between teams of basically any level.
I admit that the science component of the tournament ended up with more variation in difficulty than I had intended and that this bonus was on the easy side of the variation. However I disagree that this bonus can't distinguish between teams. You would be surprised how little science people actually know. In fact when this bonus was play tested at UVA it was only 20ed.
William Butler
UVA '11
Georgia Tech 13
Post by The King's Flight to the Scots » Sun Nov 07, 2010 10:38 am
Ondes Martenot wrote: So, my biggest complaint from this set was no uniform sense of difficulty. There was one bonus of the form amino acid/peptide bond/collagen. I guess collagen was the hard part but seriously how can a bonus like this distinguish between teams of basically any level. At the same time, there was also a John Adams (composer) bonus with a hard part on Harmonium. I'm not the best music player but these two bonuses seem they were meant for two very different tournaments. There were a lot of cases of stuff like this happening which made this set frustrating at times.
I hilariously couldn't get peptide bond in practice because I've forgotten everything I ever knew about biology.
Anyway, yeah, this set seemed to go: history<RMP<science and lit<<fine arts. I kinda felt like the history bonuses should have been a little harder at times, but, more pressingly, felt that the fine arts should have been significantly easier. Stuff like Tintoretto, Madonna of the Long Neck, that PRB bonus, and the aforementioned Adams bonus just seem too hard for ACF Fall.
Post by Mechanical Beasts » Sun Nov 07, 2010 10:39 am
There's no question that ACF Fall needs to know its identity and select its audience accordingly. I remember Eric playing Fall '08--that was his senior year, right? He did really well, of course, but it's not like he was buzzing on every single leadin. So, at that time, Fall wasn't for the very top college players.
Now--from what some top former high school players are claiming--Fall isn't for the very top college novices. While the best players to come out of high school seem to be better and better every single year, I can't imagine that 2010 Matt Jackson is much better, if at all, than 2008 Eric Mukherjee. Of course, there are second-order effects; Eric's raison d'quizbowl that year was still highly influenced by being on Jerry's team, and so he didn't especially need to hyper-optimize for being an ACF Fall level generalist--better to get a couple clues deeper on nationals level bio and chem, and have deep knowledge of a few other subjects. So while Eric was pretty sick at Fall, he could have been a lot better still if that was his goal.
But particularly with the availability of Early Autumn Collegiate Novice, ACF Fall should figure out its identity and tell the appropriate people that they should (or shouldn't) play. I'd be in favor of a Fall more like '07 or particularly '08--I don't care if the consensus is that it should be easier than this year's, but it's nice to know what to expect.
Perhaps this should be in a separate thread, but it appeared that the biggest difference between ACF Novice and ACF Fall was not question difficulty but the eligibility requirements. Last year you had ACF Fall, which in the end was roughly the same difficulty of this set, and then ACF winter which was a nice compromise between Fall and Regionals. This year you'll have Fall and then a huge jump to Regionals. I am still perplexed why Winter was eliminated in favor of ACF novice, especially since last year's Winter set seemed to get overwhelming praise. I'm all in favor of having a bunch of easy tournaments, but even without ACF novice you have ACF Fall, EFT, and MUT.
One possible idea I would be in favor of for next year: Get rid of ACF Novice, bring back ACF Winter, and put the ACF novice eligibility rules for ACF Fall. That way, there'll still be EFT for top teams looking for an early season warm up tournament.
Post by Cheynem » Sun Nov 07, 2010 11:37 am
I still think Novice was a lot easier than this set, but I guess I'd have to go back and examine both sets.
This seemed like a pretty quality set. Some interesting things were tossed up, it seemed like people who knew things were answering quickly and 30'ing bonuses and that's good. I disagree with Matt Jackson's analysis of the questions as not really rewarding gradations of knowledge. Indeed, probably not between top players, but there's just only so much Fall can do in this regard. At our site, I thought the top two teams were identified and were able to play solid, competitive matches. I agree that there were occasional inconsistencies in the bonuses.
My few complaints:
*Music featured good answer lines, but just seemed a bit top heavy, as if there was a phobia at times to put out titles. I think it is okay to put (easier) titles earlier in these cases.
*The Orioles did not win the 1973 World Series.
*The bonus part which asked for "Grendel's mother" after already mentioning Grendel and saying "her son" in the prompt was weird. Linguistic fraud aside, I will also use this bonus as a way of gently pointing out that there are certain topics that one can go "deeper" on--Beowulf is a pretty ubiquitous epic poem, oft studied and read in school. Asking for both Beowulf and Grendel's mother seems pretty easy here.
For what it's worth, this set certainly would have had enough clues to differentiate between State College and myself; I'm glad I was reading for them instead of playing. The problems at the Northeast site probably originated from the parity in skill between Yale and MIT.
ThisIsMyUsername
Post by ThisIsMyUsername » Sun Nov 07, 2010 11:49 am
Cernel Joson wrote:
I think people's criticisms of us for lacking one consistent vision of what this tournament should be are well founded, and I agree that my questions probably ended up representing the harder end of the spectrum that resulted. I honestly don't think that the answer lines for my tossups were harder than those in ACF Fall 2008 and 2009 (your two examples, Tintoretto and Madonna of the Long Neck, were tossed up ACF Fall 2009 and 2008 respectively, without complaints as far as I know), but Matt Jackson has told me that my cluing for the music tossups was too difficult, though, and Mike Cheyne's post seems to corroborate that.
Harmonium was the original hard part of the bonus as submitted. I guess I underestimated it's difficulty in choosing to keep it. I had a mental note to change the easy part on the Pre-Raphaelite bonus to just Raphael if we didn't end up doing a Raphael tossup or bonus, but forgot to do it. Sorry about that.
John Lawrence
Yale University '12
King's College London '13
“I am not absentminded. It is the presence of mind that makes me unaware of everything else.” - G.K. Chesterton
Well, the fact that Tintoretto has been asked in previous ACF Falls doesn't justify its placement in this set. It didn't belong in ACF Fall 2008 and it still doesn't belong in ACF Fall 2010. As for Harmonium, it might be a perfectly appropriate hard part for ACF Fall, but I was simply using that to compare to amino acid/peptide bond/collagen which had no hard part (you might even say it had no medium part).
Post by grapesmoker » Sun Nov 07, 2010 11:58 am
Really, Tintoretto doesn't belong in ACF Fall? When did we come to this conclusion, because I seem to have missed the part of the debate where one of the major figures of Renaissance painting was deemed too hard for this level.
mc1093alpha
Post by mc1093alpha » Sun Nov 07, 2010 12:01 pm
My general impression of the tossups of the tournament are uniformly positive, except for minor exceptions (see below). But generally I agree with the tone that there was a HUGE discrepancy between bonus parts, with questions far outside of my field that I could very easily single-handedly 30 (assuming Sam wasn't so on top of his stuff to say the answer before me :P), and some of the questions were effectively trivial. A math bonus that goes vector-Gaussian elimination-basis, really doesn't have a hard part! Anybody who graduated a basic algebra II or precalculus class could get the first two without a second thought and the 3rd is only a tiny bit harder.
Also, at least for the math questions there was a significant lack of pyramidal knowledge in the math tossup, with pretty much all math questions being first line buzzer-beats for anyone knowledgeable in the field. Dropping the Weierstrass function for differentiability in the first line, or mobius transformation/Gaussian integers for complex numbers, or "namesake manifold" for Riemann (is Kahler going to come up in quizbowl? :P), really doesn't test knowledge in the field very much. I thought the answers were appropriate difficulty but there should have been more of a lead in with hard stuff. Riemann actually was a good partial example of this, starting off with the Riemann Mapping Theorem (which I didn't catch at first) but dropping far too quickly "his namesake manifold" to make it competitive. This doesn't necessarily mean it should "harder," it should just be more pyramidal.
Benjamin Horowitz
Simsbury High School '10
Post by ThisIsMyUsername » Sun Nov 07, 2010 12:05 pm
Ondes Martenot wrote: Well, the fact that Tintoretto has been asked in previous ACF Falls doesn't justify its placement in this set. It didn't belong in ACF Fall 2008 and it still doesn't belong in ACF Fall 2010. As for Harmonium, it might be a perfectly appropriate hard part for ACF Fall, but I was simply using that to compare to amino acid/peptide bond/collagen which had no hard part (you might even say it had no medium part).
Sorry. To correct myself on dates: the previous Tintoretto and Madonna of the Long Neck tossup were both in 2008; neither was in 2009.
Obviously, you're right Aaron, if Tintoretto was a bad idea for Fall then, it's a bad idea now. I had no reason to think it was a bad idea then, though. As far as I know, no one complained about that question (which is what I would have expected were that question a difficulty outlier from that year). And I was under the impression that he was one of the most important and famous painters of the Renaissance.
Important Bird Area
Contact Important Bird Area
Post by Important Bird Area » Sun Nov 07, 2010 12:10 pm
ThisIsMyUsername wrote: As far as I know, no one complained about that question (which is what I would have expected were that question a difficulty outlier from that year).
It is quite normal for difficulty outliers to pass without comment from anyone (perhaps especially if they are genuinely important in their fields but too hard for the tournament's intended audience).
Jeff Hoppes
President, Northern California Quiz Bowl Alliance
former HSQB Chief Admin (2012-13)
VP for Communication and history subject editor, NAQT
Editor emeritus, ACF
"I wish to make some kind of joke about Jeff's love of birds, but I always fear he'll turn them on me Hitchcock-style." -Fred
Sir Thopas
Location: Hunter, NYC
Contact Sir Thopas
Post by Sir Thopas » Sun Nov 07, 2010 12:14 pm
Cheynem wrote: *The Orioles did not win the 1973 World Series.
Awful mistake on my part, conflated it with 1969. My apologies.
Guy Tabachnick
Hunter '09
Brown '13
http://memoryofthisimpertinence.blogspot.com/
Post by Ethnic history of the Vilnius region » Sun Nov 07, 2010 12:18 pm
I thought the tournament was fine. A few clunkers here and there and a few too many repeats, but it was decent overall. I'll leave the identity stuff to the higher-ups, but good teams/players did good but seemed sufficiently challenged and the event was
This is a minor point, but since it no doubt impacted matches, it's worth bringing up. The sports seemed really skewed towards minor/international sports. Besides the Orioles tossup, no other sports question read at our mirror had to do with football, basketball, or baseball. There was a common-link tossup on South African sports, a Federer tossup, a soccer bonus on Portugal, a soccer bonus on the World Cup, and a soccer bonus on American players. I'm fine with some questions on minor/international sports. I especially liked the Federer one. But those sports shouldn't be asked 5:1 over the most popular sports in the U.S. The soccer questions especially had accessibility issues that could have been easily remedied with a bonus or two on one of the three major U.S. sports.
Post by The Toad to Wigan Pier » Sun Nov 07, 2010 12:47 pm
mc1093alpha wrote: math bonus that goes vector-Gaussian elimination-basis, really doesn't have a hard part! Anybody who graduated a basic algebra II or precalculus class could get the first two without a second thought and the 3rd is only a tiny bit harder.
Not true. I personally know many people who took and excelled in Algebra II who have no idea what Gaussian elimination is. Unless you have taken linear algebra or have lots of quizbowl experience, you probably don't know what a basis is. If you have taken linear algebra or been playing a lot of quizbowl, you will get 30, which is the point!
mc1093alpha wrote: Also, at least for the math questions there was a significant lack of pyramidal knowledge in the math tossup, with pretty much all math questions being first line buzzer-beats for anyone knowledgeable in the field. Dropping the Weierstrass function for differentiability in the first line, or mobius transformation/Gaussian integers for complex numbers, or "namesake manifold" for Riemann (is Kahler going to come up in quizbowl? :P), really doesn't test knowledge in the field very much. I thought the answers were appropriate difficulty but there should have been more of a lead in with hard stuff. Riemann actually was a good partial example of this, starting off with the Riemann Mapping Theorem (which I didn't catch at first) but dropping far too quickly "his namesake manifold" to make it competitive. This doesn't necessarily mean it should "harder," it should just be more pyramidal.
In retrospect, the fact that Riemann manifolds exist should have come later in the question. But honestly the binary association between "namesake manifold" and Riemann is a foolish one as noted really important mathematicians Hilbert, Poincaré, and Banach have namesake manifolds among others. Note: I'm not trying to imply that there should be a ACF Fall tossup on Banach. Also if you know what the domain for a Mobius transformation is, good for you. Most quizbowlers don't.
Post by pray for elves » Sun Nov 07, 2010 12:54 pm
mc1093alpha wrote: stuff about math being easy
Don't fall for the Freshman Fallacy.
I don't know what your Algebra II and Precalculus classes were like in high school, but mine didn't talk about Gauss-Jordan elimination; the first time I was taught about it was in linear algebra. Complaining about the Weierstrass function being early in an ACF Fall tossup is a bit silly, honestly. Most people don't know it. You clearly are not most people; be glad and take your points. I haven't seen the set, but if the clues that came after Weierstrass were easier, then it was fine in construction and I doubt the question was too easy for the field.
Post by Ondes Martenot » Sun Nov 07, 2010 12:59 pm
Despite the criticisms I've been making about this set (some of which may be entirely unjustified), I want to say that in the end I thought this was a good set. A step down from last year's ACF Fall, but still successful in achieving its intended purpose. My frustration has a lot more to do with the fact that I only got to play 7 rounds in 10 hours yesterday.
As for Tintoretto, he is definitely an important artist, but I was under the impression that when in doubt for ACF Fall, trend on the easy side. So if you have to choose between Tintoretto and School of Athens, choose School of Athens even if you aren't in the mood to write the 10 millionth question on that painting (its possible something on the school of athens was in the many, many rounds I did not play on yesterday).
Also, I have yet to hear anyone give their opinion on what I said earlier
I know I have no position within ACF but I'm curious as to what people think of this.
Ondes Martenot wrote: Also, I have yet to hear anyone give their opinion on what I said earlier
This is a pet peeve of mine and not like, an official board reprimand or anything, but I still think it's worth saying: you made that statement two hours ago. There's no way ACF's going to have an official position on anything that was proposed two hours ago.
Post by Sir Thopas » Sun Nov 07, 2010 1:24 pm
Ethnic history of the Vilnius region wrote: This is a minor point, but since it no doubt impacted matches, it's worth bringing up. The sports seemed really skewed towards minor/international sports. Besides the Orioles tossup, no other sports question read at our mirror had to do with football, basketball, or baseball. There was a common-link tossup on South African sports, a Federer tossup, a soccer bonus on Portugal, a soccer bonus on the World Cup, and a soccer bonus on American players. I'm fine with some questions on minor/international sports. I especially liked the Federer one. But those sports shouldn't be asked 5:1 over the most popular sports in the U.S. The soccer questions especially had accessibility issues that could have been easily remedied with a bonus or two on one of the three major U.S. sports.
I worried a bit about this when I was editing the trash. I didn't get any stuff on major sports except, I believe, a tossup on the Lakers (I wrote the Orioles tossup and a bonus on the Titans for the editors' packet), and I got a ton of soccer. In general, my philosophy was to keep the answers unless they were way too hard, even if it was stuff I personally found a bit odious (does anyone actually like Cats?). I tried not to make the trash too much towards my personal preferences; perhaps I erred too far in this direction and should have replaced a soccer bonus or two with the other football.
I also have to show my chagrin at arguments like "everyone knows Gaussian eliminations, there's no hard part here!" and "speaking as someone who might have been the best high school quiz bowl player last year and who scored 147 ppg at a high school national tournament that is about as difficult as ACF Fall, if not more so, I have to say that ACF Fall is far too easy."
"Gaussian eliminations" is not an easy answer.
I doubt that ACF Fall was too easy just because Matt Jackson answered lots of questions at it.
Post by Mike Bentley » Sun Nov 07, 2010 1:26 pm
I think this is an awful idea. ACF Novice was a great tournament that did good things for getting players never involved in quizbowl before. It was significantly easier than ACF Fall and I don't think can be easily replaced by just strapping eligibility restrictions on ACF Fall.
We don't need to do more things to cater to experienced players--there are already enough tournaments on the calendar for that (e.g. everything from January-onwards that isn't MUT and DII SCT). I don't know the specifics of it, but I think there were pretty much regular season difficulty tournaments every weekend from mid-January until March last year, which made ACF Winter pretty superfluous. Is it really going to kill us to have one less of these tournaments (and even then I'm not sure this is the case, as TIT is now in the Winter) so that some extra resources can be expended to get more novices into the field and offer more stuff for less experienced circuits to play?
Post by Ondes Martenot » Sun Nov 07, 2010 1:35 pm
If that is indeed the reason ACF winter was dropped (that is, already a lot of regular difficulty tournaments) then I take back what I said in terms of bringing Winter back. I still don't quite see the reasoning for having both ACF Fall and Novice. ACF Novice seemed like it was a true novice event whereas ACF Fall had the feeling of very good teams playing pretty easy questions simply because there were no eligibility rules to stop them. AT UVA, it seems like ACF Fall was essentially an event where very good high school teams could play each other on questions somewhat harder than a regular high school set.
Post by dtaylor4 » Sun Nov 07, 2010 2:14 pm
Ondes Martenot wrote: If that is indeed the reason ACF winter was dropped (that is, already a lot of regular difficulty tournaments) then I take back what I said in terms of bringing Winter back. I still don't quite see the reasoning for having both ACF Fall and Novice. ACF Novice seemed like it was a true novice event whereas ACF Fall had the feeling of very good teams playing pretty easy questions simply because there were no eligibility rules to stop them. AT UVA, it seems like ACF Fall was essentially an event where very good high school teams could play each other on questions somewhat harder than a regular high school set.
You're using one site to extrapolate to every single mirror? Come on, dude. Not every circuit has half a dozen high school teams lining up to play this, and beat down on college teams in the process.
Not all college players come in at the same level of experience/skill. Some have never played, some have played a local format or some circuit qb, some played a lot of circuit qb but aren't that good, and then at the top you have guys like Matt Jackson.
I'm not saying we should baby people, far from it. All I'm saying is that we shouldn't try to favor one over the other, which you seem to want to do.
Not all college players come in at the same level of experience/skill. Some have never played, some have played a local format or some circuit qb, some played a lot of circuit qb but aren't that good,
Isn't this the intended audience for ACF Novice though? I said a couple of posts back that ACF Novice should be dropped and eligibility rules should be placed in ACF Fall. Rethinking, it would be much more appropriate to keep ACF Novice and drop Fall and leave EFT as the "easy tournament for good teams". I realize the chance of ACF Fall realistically getting dropped is extremely slim, so this is probably me just thinking aloud.
kayli
Post by kayli » Sun Nov 07, 2010 2:25 pm
Sir Thopas wrote: (does anyone actually like Cats?)
A pet peeve I had was that in one of the packets there were 6 or so tossups or bonuses about people or things related to Russia. It might be alright for quizbowl purposes, but it just seemed weird to me. Another complaint I had was that bonus difficulty seemed to fluctuate quite a lot. Mainly it seemed like a lot of bonuses lacked middle parts, but that's always hard to do. I was pretty happy overall with the tossups. It seemed to fluctuate in difficulty sometimes, but overall they seemed well written for the level of competition. Overall, however, this was probably the best set I've ever played on. It was a really fun and rewarding experience.
Kay, Chicago.
Rufous-capped Thornbill
Post by Rufous-capped Thornbill » Sun Nov 07, 2010 2:34 pm
I'll echo some of the sentiments expressed here. A lot of the bonuses were an easy, automatic 20 for anyone who was experienced with quizbowl. The tossups seemed to do a good job of differentiating knowledge. At least at our site, there didn't seem to be that many bad buzzer races.
My biggest complaint was the amount of repeats. Just off the top of my head, Sartre and Gibbs Free Energy were repeated, both in the same round.
But overall, I fairly enjoyed playing this site. The trash was pretty awful, though. Pokemon? Monsters Inc? Common link on Hippos? And of course there was a lack of popular American Sports.
But that's trash, so no big deal.
Jarret Greene
South Range '10 / Ohio State '13 / Vermont '17
Post by The King's Flight to the Scots » Sun Nov 07, 2010 2:36 pm
Inkana7 wrote: I'll echo some of the sentiments expressed here. A lot of the bonuses were an easy, automatic 20 for anyone who was experienced with quizbowl. The tossups seemed to do a good job of differentiating knowledge. At least at our site, there didn't seem to be that many bad buzzer races.
This set's trash was my favorite in over a year, and those questions in particular were among my favorites in the set.
Post by Sen. Estes Kefauver (D-TN) » Sun Nov 07, 2010 2:39 pm
Things people know about in popular culture? Why I never!
Jeremy Gibbs Freesy Does It wrote:
Hey, I'm a trash fan. I enjoy playing it. I meant awful more in a "argh kiddie/weird trash" rather than "argh I hate trash" manner.
2008-09 Male Athlete of the Year
Post by Cody » Sun Nov 07, 2010 2:46 pm
Inkana7 wrote: Just off the top of my head, Sartre and Gibbs Free Energy were repeated, both in the same round.
Was Sartre really a repeat? At the point the question was gotten in my room, it was all about his philosophy stuff, and the earlier bonus was about his literature. Personality was definitely a repeat in that round though (with clue overlap), but that and gibbs free energy are the only ones I can really recall.
Edit - Just want to add that I enjoyed this tournament and didn't think it was too easy at all.
Last edited by Cody on Sun Nov 07, 2010 3:07 pm, edited 1 time in total.
Cody Voight, VCU ‘14. I wrote lots of science and am an electrical engineer.
VCU Tournament Director ‘13-‘17. HSAPQ President ‘15-16.
Hero of Socialist Quizbowl Labor (NSC ‘14). “esteemed colleague” of Snap Wexley, ca. 2016. Stats Hero (Nats ‘16).
Quizbowl at VCU
Post by Nine-Tenths Ideas » Sun Nov 07, 2010 2:48 pm
I agree with some of what's been said here [a little variant difficulty, a little bit of repeats, a little seltzer down your pants] but disagree with a lot of it. While I'm glad a lot of people have deemed themselves just too good for this tournament, and people should be ashamed for writing it, I found that really wasn't the case. I'll use my team as an example-- Maryland B was composed of 4 reasonably good quizbowl players, two captains of teams that did alright at NSC last year and two people who have been playing college quizbowl for a while now, and I don't think any of us would claim the set was too easy for us. Plenty of bonuses were not "automatic 20s or 30s," lots of questions were not too easy for players of our caliber, etc.
But if people want to continue their macho quizbowl posturing because this set was just too easy for them, then, by all means, continue.
Inkana7 wrote:
"Argh movies made by Pixard and Disney that grossed over half a billion dollars that were released 9 years ago, which just happens to be when most freshmen were 9 (and those right in the target audience for the film)."
Adventure Temple Trail
Post by Adventure Temple Trail » Sun Nov 07, 2010 2:54 pm
Having written for ACF Novice and seen the packets, I can assure everyone involved that it was intended to be, and was, much easier than this set. I am of the opinion that drawing an equivalency between ACF Novice and ACF Fall is pointless and wrong; they have different target audiences, different objectives, and different difficulties, and both should absolutely exist.
I agree with all the following: Yeah, ACF Fall is meant to be easy, and it's an incredible positive good that it is. Yeah, Neil, Stephen, and I are going to do incredibly well on a set designated "easy" no matter what. This isn't wrong, and I wouldn't want my performance to imply that future ACF Falls should be harder in a way that would harm 90+ percent of the field. I am certainly not a "macho quizbowl posturer" as Isaac seems to imply.
I just haven't gotten a clear answer yet as to this question: Should I have just stayed home or not played at all? If the set were going to be easy enough at the beginnings of tossups and ends of bonuses that gradations between me, Stephen, and Neil ended up not mattering (and to some extent between all of the above, Sam Spaulding, Aaron Cohen, and the Ben Cohen/Rebecca Maxfield duo as well), then there wasn't a real point in us being there, it'd just be frustrating, and we should have let other teams duke it out for the top spot. In that case, the top spot would be, by design, irrelevant enough for the best incoming players (who'd buzzer race and 30 about half the time) that other teams could take home some books, we could staff, and everyone could call it a day.
If the set were going to still be easy as it should, but be differentiable enough for non-champion "good players" in the beginnings of tossups and third parts of bonuses (i.e. more HSNCT/NSC/MUT/EFT 3rd part material, more often), it would make more sense for people such as Stephen, Neil, Aaron Cohen, or me to go to the tournament, accept a little bit of easy-tournament wonkiness, determine a winner despite some of that wonkiness, and then call it a day in addition to the rest of the field. This road wouldn't have made things much different for teams that generally got 20ppb or lower on this set, and would have the effect of making the cluster of 20+ ppb teams at Fall split more fairly according to their knowledge/skill.
My uncertainty: which of these Falls did the editors intend to make? My view is that they produced the former situation which wasn't ideal, though I'll admit the tossups were on the whole much, much better about this than the bonuses. It'd only take a bit of tweaking of beginnings and ends to make a Fall a lot better at distinguishing high school champions and good college teams missing their championship players - that, or on the other hand it can stay largely as it was with a more clear advisory to (the relatively new phenomenon of) high school champions and (older phenomenon of) good non-championship college teams that their games might not mean much. Though I advocate the latter, either seems like an acceptable course of action to me - after all, I personally am not going to play Fall '11, simply because at that stage in my development it won't make sense to.
Yeah, my comments in science were basically that it had a protein/peptide/collagen bonus on one hand and a tossup on oxidation that did a bunch of organic chemistry and then dropped "loses electrons" at the bitter end on the other and just generally should have been more consistent.
And re: Kay Li: No. No one likes Cats. Not that it or any other trash was by nature a bad answer choice, it's just awful.
Last edited by Adventure Temple Trail on Sun Nov 07, 2010 3:13 pm, edited 1 time in total.
Matt J.
ex-Georgetown Day HS, ex-Yale
Try my original crossword puzzles
tiwonge
Location: Boise (City of Trees), Idaho
Post by tiwonge » Sun Nov 07, 2010 3:00 pm
Arsonists Get All the Girls wrote:
Something similar happened on a packet I was reading. The UW team had an Iranian player, and there were 3-4 questions relating to Iran in that packet (as well as a geography question about Iran in the next packet).
I'm not complaining about it, because I know stuff like this happens (and none of the questions were bad, or anything). I just thought it was an interesting anomaly.
Colin McNamara, Boise State University
Idaho Quiz & Academic Teams
nadph
Post by nadph » Sun Nov 07, 2010 3:01 pm
mc1093alpha wrote: A math bonus that goes vector-Gaussian elimination-basis, really doesn't have a hard part!
If this bonus appears where I think it does, I believe it as submitted was vector/linear transformation/Markov chain (the theme was "stuff that can be done with matrices", with the tie-in to Markov chains being transition matrices); would you say this is also too easy (or easier)?
Also, should we expect packets to be posted soon, or will that only happen after the Oxford mirror?
Nikhil Desai
Bellarmine College Prep '12
Stanford '12-'15, '18
nadph wrote:
Yours was a separate bonus which remained relatively intact.
CaptainSwing
Post by CaptainSwing » Sun Nov 07, 2010 3:04 pm
I think what is being lost here is that on the whole it was a well written tournament. The humanities area questions (history, lit, FA) were especially all well written. Whatever issues people may have with difficulty, etc. the questions were not plagued by poor structure. Especially on tossups, I thought buzzer races were avoided very nicely.
My complaint lies with some of the science questions. I remember several questions, all science, which were like a pure regurgitation of Wikipedia information. Science questions do not need to be a laundry list of "blue link" information with a definition as the giveaway. Plus, there were a few moments of total absurdity: what galaxy is Earth in? For real?
Max Henkel
Carleton '14
Writer, NAQT
QuizbowlTribune
Post by QuizbowlTribune » Sun Nov 07, 2010 3:17 pm
A little levity, I hope.
Offering the best in kind of satirical Quizbowl articles since 1998, maybe
Post by marnold » Sun Nov 07, 2010 3:19 pm
I just haven't gotten a clear answer yet as to this question: Should I have just stayed home or not played at all?
If it means we can avoid the seemingly annual ritual of "I'm good and this didn't cater to how good I am so this suxx," then yes - ten thousands times yes, please stay home. I know high schoolers and young college players worship the ground Shantanu walks on, so maybe this little parable will help you: his first year, Shantanu knew ACF Fall was going to be easy for him. He played, he predictably blew the set out of the water, and he even lost games because he and another good opponent were both buzzing on most of the lead-ins and 30-ing most of the bonuses. Yet, he didn't feel compelled to complain about that, either in person or on the forums. Lesson: if you're good, either learn the appropriate way to act about being good at quizbowl, or STAY HOME FROM EASY TOURNAMENTS.
RyuAqua wrote: Having written for ACF Novice and seen the packets, I can assure everyone involved that it was intended to be, and was, much easier than this set. I am of the opinion that drawing an equivalency between ACF Novice and ACF Fall is pointless and wrong; they have different target audiences, different objectives, and different difficulties, and both should absolutely exist.
But my main concern is this. I agree with the following: Yeah, ACF Fall is meant to be easy. Yeah, Neil, Stephen, and I are going to do incredibly well on a set designated "easy" no matter what. This isn't wrong, and I wouldn't want my performance to imply that future ACF Falls should be harder in a way that would harm 90+ percent of the field. I am certainly not a "macho quizbowl posturer" as Isaac seems to imply.
My uncertainty: which of these Falls did the editors intend to make? My view is that they produced the former situation which wasn't ideal, though I'll admit the tossups were on the whole much, much better about this than the bonuses. It'd only take a bit of tweaking of beginnings and ends to make a Fall a lot better at distinguishing high school champions and good college teams missing their championship players - that, or on the other hand it can stay largely as it was with a more clear advisory to (the relatively new phenomenon of) high school champions and (older phenomenon of) good non-championship college teams that their games might not mean much. Though I advocate the latter, either seems like an acceptable course of action to me - after all, I personally am not going to play Fall '11.
Really, you were buzzing on the first clue of every tossup? Because when I was practicing on these, I definitely didn't; looking at this packet I have open from yesterday, I got 3 tossups on the first line and 3 in the first few words of the second line. In other words, there were clues I didn't know in 17 out of the 20 tossups in this packet. Granted, if two teams really did know every lead-in to every tossup, then the set would be too easy for them...other than the questions you got late. Those were impossible.
Having seen State College play, I'll say this: if you really were decisively better than MIT, you'd have beaten them decisively on this set. However, since by all accounts you were at roughly the same level of skill, this set wasn't optimal for the subtle job of differentiating between you.
Post by Cheynem » Sun Nov 07, 2010 3:27 pm
There seems to be a bit of selective memory going on when people are thinking about bonuses. There were a number of bonuses which featured pretty darn hard bonus parts--Convergence of the Twain WITHOUT Hardy? The maid from Long Day's Journey Into Night? Remembering Jack's name from The Importance of Being Earnest without knowing the play or author? Harmonium? Kamehameha off good, solid clues and not just Hawaiian king? I could probably go on for a few more examples, but these seem like a number of fine HSNCT/NSC/MUT hard parts, perhaps even too hard (Convergence of the Twain especially). Perhaps the New England site featured more fantastical teams, but I didn't see these inability-to-gradate-differences-between-good-teams situation at our site.
I'm not denying that there was a bit of inconsistency at times in some of the distribution areas (something that's common to many tournaments), but I also disagree with this general assessment of Fall as like some tournament in an identity crisis. The last few years Fall has been pushed as primarily for new players/novices. The increased merging of the high school/college circuits have ensured that even many freshmen are not new players or novices.
Dan-Don
Location: Evanston
Contact Dan-Don
Post by Dan-Don » Sun Nov 07, 2010 3:31 pm
RyuAqua wrote: And re: Kay Li: No. No one likes Cats. Not that it or any other trash was by nature a bad answer choice, it's just awful.
This is quite possibly the most sensible thing said so far. I love Broadway, and it so infrequently comes up, I don't wanna be subjected to crap when it does. That said, thank you Kay Li for writing about a musical.
I'm sorry my hippos tossup wasn't well-received.
Dan Donohue, Saint Viator ('10), Northwestern ('14), NAQT
Oh, I didn't write that; but I did like the musical Cats way back in my youth when I saw it (maybe that's why I liked it).
Post by Habitat_Against_Humanity » Sun Nov 07, 2010 3:44 pm
I thought this tournament was actually pretty solid. The difficulty seemed to be controlled even if it was almost skewed a little too easy. I think the thing I appreciated most about this tournament was that it stuck to the standard of what good, established quiz bowl questions should be like. Except for "Urban Planning" and "Personality" (the latter of which was described as a "phenomenon"), there seemed to be no attempt to insert wacky or even remotely experimental answer lines. The number of repeats was a little confounding, as were several factual errors (British Columbia was referred to as a "territory" leading me to wonder how the hell wine was grown in the Yukon and saying Miguel Tejada was part of the Orioles was probably wrong when the question was written). My biggest issue with the tournament was the form of many of the lit bonuses. All too often it seemed that the order of a given lit bonus seemed to be:
1. Name a character or work.
2. Name another work or the author of aforementioned work.
3. Name the author or another work.
Unfortunately, I won't be able to give explicit examples of this until I look at the set, but this did seem to happen fairly frequently. My problem with this sort of ordering, especially in an ostensibly easier tournament, is that the bonus intro and first clue forces a team to search their brains for a character or work with no contextual clues to place it in. For example, I've never gotten around to reading Nausea, but I certainly know it's by Sartre. As I recall, Nausea was the first part neither I nor my teammates had any clue as to what sort of work was being asked about. Had one been given Satre or even that is was by the author of The Respectful Prostitute, I have a feeling that the conversion would be much much higher. I don't if this was an attempt to play with the difficulty order, but it seems to me that a "hard" part of a bonus should actually be on something hard rather than asking about something a team most likely knows about but lacks a context to place it in. I don't know if I'm getting my point across very well here, but that was my main issue.
Also: If you're going to bring buzzers to a tournament, you better goddamn well make sure that they work. More on this later.
lasercats
Location: Tulsa/Norman OK.
Contact lasercats
Post by lasercats » Sun Nov 07, 2010 3:50 pm
Sir Thopas wrote:
I agree. We heard quite a bit of European football, the Orioles question, and an 80s basketball question. If this is supposed to be an entry-level tournament, that means the freshmen playing it were born in...1993?
I noticed at our site (4 teams, mind you) that there were very few 30s on the bonus. In fact, there were more 10s than anything. At the same time, very few tossups went dead in my room, maybe 9 in as many rounds. I think that's pretty good, especially since one of our teams was completely new to quizbowl.
The Queensland bonus was very awkward, because it said something about it being a state in its given country, but never gave the country. Neither of the following questions has "Australia" for an answer, so why not say "the third largest state in Australia"?
As a moderator, I appreciated whoever broke up the Aztec words by the syllables. That presentation would be nice for other really large words, especially for those of us who have not had a lot of science, or perhaps this is something that I will do in advance next time.
Maggie Larkin
Booker T. Washington '07
University of Oklahoma '11
Oh man, the urban planning one was absolutely awesome. I agree the answer line was a bit odd (maybe write it on "cities" instead?), but so much goodness coming in that tossup.
Any thoughts as to the tossup on the Brothers Grimm that called the two "this author"? I know it's trying to avoid transparency, but it's a bit odd.
I wasn't listening too carefully to it, but the lead-in to the Isaac tossup said something about him lying about his wife being his sister to Abimelech. This is true for Isaac, but it is also true for his father Abraham (maybe the tossup mentioned him copying his father, I don't know).
I agree with your assessment on lit, Nolan. My other general concern about some of the lit questions was that they tended to be a bit lead-in heavy by playing title bowl. For instance, off the top of my head, I am thinking of the Thornton Wilder tossup. The lead-in mentioned Theophilus North, a work I doubt many people have read. The description of it was pretty vague and the title came right after it. So in effect, that tossup was playing Title Bowl. While I don't want to sound like a grump and say "RAAAAAR TITLES," I will suggest that in cases where the author has produced works more likely to be read, wouldn't it be better to reward knowledge of those?
EDIT: Again, I want to emphasize to the editors and everyone that this was an excellent set. My questions here are genuine attempts to offer feedback on both specific and general aspects of this set and I'm sorry I don't have more examples about why I really liked about this set because the players from our teams and I certainly liked it.
Last edited by Cheynem on Sun Nov 07, 2010 4:02 pm, edited 1 time in total.
SirT wrote:
There was a Sartre philosophy question and a Sartre lit question; as the editor of the former, I made sure to not touch on his literary career at all. It's a pity they were both in the same round, though.
Cheynem wrote: Oh man, the urban planning one was absolutely awesome. I agree the answer line was a bit odd (maybe write it on "cities" instead?), but so much goodness coming in that tossup.
To be fair, directly after that clue there was a plot description of The Skin of our Teeth, which fits into the "description of important works" category.
EDIT: Substance
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Book Revue: The Juice
I recently finished reading Will Carroll's book, The Juice: The Real Story of Baseball's Drug Problems. I fully intended to write a book review about it, but when I sat down to do it, I made an unfortunate typographical error.
Instead of a book review, I accidentally made a "book revue". I know it's not quite the same, but stuff happens.
Book Revue: The Juice.
low bandwidth version (368 Kb, mp3 audio file)
medium bandwidth version (981 Kb, mp3 audio file)
high bandwidth version (1.72 Mb, mp3 audio file)
My deepest apologies to Will Carroll, and anyone who dares to listen to the revue. My blunders aside, "The Juice" is a good book. You should buy it.
Alphabetic Overplacings Considered Harmful
TFD sent me this New York Times article about a controversy regarding W.H. Auden's translation of Dag Hammarskjöld's "Vägmärken". We had an interesting back and forth about it, which I'll share:
Score Bard: Anyone who wants to translate "Vägmärken" as "Waymarks" doesn't deserve to complain about the quality of a translation. Just because a word is a direct cognate doesn't mean it's the right choice. I've never even heard of the word "waymark". To me, that's not even English.
"Road signs" or "Milestones" are what popped into my head.
I've read bits and pieces of it before in Swedish. Now I suppose I'm going to have to read the whole thing, and both versions...
TFD: The case against Auden, though, seemed pretty good--that he was putting his own "map" onto Hammarskjöld. (Not that i'd have any idea, really.)
Score Bard: Without reading both, I'd have no idea, either. That's part of the problem with translating poetry, though. Do you translate the words or the artistry? It's a delicate balance, and I suppose it's possible Auden could have exploited his artistic license a bit too much.
TFD: You try to get to (as close as possible) the complete meaning of the originator. That includes everything (artistry)...imho, of course.
Score Bard: Sure, but some things just don't translate directly. Sometimes you really do have to make a choice between preserving the original beauty and preserving the original semantics. If you translated one of my serious baseball poems into Swedish (not that anyone would want to, but bear with me), it would be meaningless to 99.9% of Swedes, who don't even know what a baseball looks like. You'd have to find something else--soccer or hockey maybe, or even something outside of sports--to convey the underlying message. If you stuck too close to baseball, you wouldn't have communicated anything at all. It's tricky.
TFD: Hmm. Well in your example i guess it depends upon whether or not you were saying something universal that could be communicated through baseball. If not, and most Swedes didn't know baseball, then why even translate? You can't change it to soccer and make it even remotely the same poetry (again unless there are some larger universal things that could be drawn.) but even in that case I'd be pretty hesitant.
That would be like translating Sagan's work into Mandarin by using meterology or Christianity as a metaphor. Yikes, bad example, but i think you get my drift.
Score Bard: Well, that's why I was saying "serious" baseball poetry, because there's usually some universal message involved if it's "serious". The key is to convey the same message.
The problem with translating poetry is that there's so much more to translate than just pure semantics. It's not like translating newspapers, which I used to do for a living. There's the harshness or softness of the sounds, the smoothness or roughness of the rhythm, there's the way one word will relate to another just by having similar sounds or meanings or connotations. All of those things are present in a great poem, and most of those things will be lost if you just do the most accurate literal translation of the meanings of each word or each metaphor.
I always found the hardest part about translating is when there was a word in one language with several equivalent words in the other, but none with quite the same connotation. "Vägmärken" is a perfect example. "Road signs", "Milestones", "Landmarks"--those words just don't convey the same image. Those three translations feel to me like they all have somewhat positive connotations in English, but in Swedish, the word to me has a certain inevitable loneliness and sadness to it--you imagine traveling a small winding road through the Swedish forest, and coming across a milestone left behind centuries before you, by people long since dead.
So if you want to convey that inevitability, that loneliness, that sadness, that sense of historical context which is built into the Swedish word, you can't just translate the word directly into English and leave it at that. You have to find some other way to convey those emotions.
TFD: I agree with you completely that you can't just translate literal words. I was just saying you have to say within what you, the translator, deem to be the "meaning" of the original poem/writing. you have to stay as close as possible, while giving up as much as possible your own prejudices, etc. So in many ways you need to be reporter, historian, wordsmith, and world semantic expert.
I think, again based on my limited view of the article, that the claim being made was that Auden was going outside 'generally accepted guidelines' if such a thing existed. I'd like more verification from an Auden scholar to review the translation who is familiar with Swedish...he/she could ascertain whether or not the lens that Auden was using was too cloudy.
Score Bard: Yes, Baseball has its unwritten rules, as does poetry translation, I suppose. I have a pretty simple to-do list now:
Write down all those unwritten rules once and for all
Get out the Yellow Pages, and call one of the numerous Swedish-speaking Auden scholars listed therein.
Go down to my corner bookstore and buy a copy of "Vägmärken" in both English and Swedish.
I'm rather busy tonight, but I should have time to get those things done before lunch tomorrow. It's only three things, after all.
I Call Sexson Babe's Lad
He worships Seattle-based dessert food:
"Thornton secretive cake."
Adrian Beltre cuts off other bread bins,
And darn never eats chicken.
Brilliantly Boone burps egg flour chunks,
Managing to eat it in bold haiku-
Winn hath wrought thy butter, Olivo eats bread:
Tony Pena Resigns
It looks like the leader of Royalty
Unloaded all pledges of loyalty
Cuz his passionate blood,
When his team was a dud,
Reached near-fatal levels of boilty.
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Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys
M. Pisarek, M. Janik-Czachor, A. Gebert, A. Molnár, P. Kedzierzawski, B. Rác
Hydrogen charging of Cu65Hf35 and Cu61Hf39 amorphous alloy (AA) ribbons at i=-1mA/cm2 in an alkaline solution (0.1M NaOH) was used to study the effect of hydrogenation on the processes of morphology and crystallization. A similar procedure was applied in an acid solution (0.1M H2SO 4) to introduce more hydrogen to bring about more pronounced morphological and structural changes. The samples were then catalytically tested for dehydrogenation of 2-propanol. Catalytic activity increased up to 88% at selectivities to acetone of about 95%. The structural, chemical, and morphological changes were followed by X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray electron probe microanalysis (WDS). The hydrogen content was determined by elemental analysis, or by gas extraction.
Applied Catalysis A: General
https://doi.org/10.1016/j.apcata.2004.02.031
Amorphous alloys
Wavelength dispersive spectroscopy
Catalyst selectivity
Electron probe microanalysis
Dehydrogenation
Cathodic hydrogen charging
Cu-based alloys
Dehydrogenation of z-propanol
Microscopic characterization
Pisarek, M., Janik-Czachor, M., Gebert, A., Molnár, A., Kedzierzawski, P., & Rác, B. (2004). Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys. Applied Catalysis A: General, 267(1-2), 1-8. https://doi.org/10.1016/j.apcata.2004.02.031
Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys. / Pisarek, M.; Janik-Czachor, M.; Gebert, A.; Molnár, A.; Kedzierzawski, P.; Rác, B.
In: Applied Catalysis A: General, Vol. 267, No. 1-2, 30.07.2004, p. 1-8.
Pisarek, M, Janik-Czachor, M, Gebert, A, Molnár, A, Kedzierzawski, P & Rác, B 2004, 'Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys', Applied Catalysis A: General, vol. 267, no. 1-2, pp. 1-8. https://doi.org/10.1016/j.apcata.2004.02.031
Pisarek M, Janik-Czachor M, Gebert A, Molnár A, Kedzierzawski P, Rác B. Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys. Applied Catalysis A: General. 2004 Jul 30;267(1-2):1-8. https://doi.org/10.1016/j.apcata.2004.02.031
Pisarek, M. ; Janik-Czachor, M. ; Gebert, A. ; Molnár, A. ; Kedzierzawski, P. ; Rác, B. / Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys. In: Applied Catalysis A: General. 2004 ; Vol. 267, No. 1-2. pp. 1-8.
@article{8e13246d01ff45709935dbf60791b6ce,
title = "Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys",
abstract = "Hydrogen charging of Cu65Hf35 and Cu61Hf39 amorphous alloy (AA) ribbons at i=-1mA/cm2 in an alkaline solution (0.1M NaOH) was used to study the effect of hydrogenation on the processes of morphology and crystallization. A similar procedure was applied in an acid solution (0.1M H2SO 4) to introduce more hydrogen to bring about more pronounced morphological and structural changes. The samples were then catalytically tested for dehydrogenation of 2-propanol. Catalytic activity increased up to 88{\%} at selectivities to acetone of about 95{\%}. The structural, chemical, and morphological changes were followed by X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray electron probe microanalysis (WDS). The hydrogen content was determined by elemental analysis, or by gas extraction.",
keywords = "2-Propanol, Amorphous alloys, Catalyst, Cathodic hydrogen charging, Cu-based alloys, Dehydrogenation of z-propanol, Microscopic characterization",
author = "M. Pisarek and M. Janik-Czachor and A. Gebert and A. Moln{\'a}r and P. Kedzierzawski and B. R{\'a}c",
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journal = "Applied Catalysis A: General",
T1 - Effect of cathodic hydrogen charging on catalytic activity of Cu-Hf amorphous alloys
AU - Pisarek, M.
AU - Janik-Czachor, M.
AU - Gebert, A.
AU - Molnár, A.
AU - Kedzierzawski, P.
AU - Rác, B.
N2 - Hydrogen charging of Cu65Hf35 and Cu61Hf39 amorphous alloy (AA) ribbons at i=-1mA/cm2 in an alkaline solution (0.1M NaOH) was used to study the effect of hydrogenation on the processes of morphology and crystallization. A similar procedure was applied in an acid solution (0.1M H2SO 4) to introduce more hydrogen to bring about more pronounced morphological and structural changes. The samples were then catalytically tested for dehydrogenation of 2-propanol. Catalytic activity increased up to 88% at selectivities to acetone of about 95%. The structural, chemical, and morphological changes were followed by X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray electron probe microanalysis (WDS). The hydrogen content was determined by elemental analysis, or by gas extraction.
AB - Hydrogen charging of Cu65Hf35 and Cu61Hf39 amorphous alloy (AA) ribbons at i=-1mA/cm2 in an alkaline solution (0.1M NaOH) was used to study the effect of hydrogenation on the processes of morphology and crystallization. A similar procedure was applied in an acid solution (0.1M H2SO 4) to introduce more hydrogen to bring about more pronounced morphological and structural changes. The samples were then catalytically tested for dehydrogenation of 2-propanol. Catalytic activity increased up to 88% at selectivities to acetone of about 95%. The structural, chemical, and morphological changes were followed by X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray electron probe microanalysis (WDS). The hydrogen content was determined by elemental analysis, or by gas extraction.
KW - 2-Propanol
KW - Amorphous alloys
KW - Catalyst
KW - Cathodic hydrogen charging
KW - Cu-based alloys
KW - Dehydrogenation of z-propanol
KW - Microscopic characterization
U2 - 10.1016/j.apcata.2004.02.031
DO - 10.1016/j.apcata.2004.02.031
JO - Applied Catalysis A: General
JF - Applied Catalysis A: General
10.1016/j.apcata.2004.02.031
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Debis
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Kamil Pasa Mansion at Bridge stop #6 in Mithatpasa Street was reserved for the Higher Islamic Institute of Izmir on November 21, 1966 by philanthropist Haci Ahmet Tatari.
A room in the basement was also reserved as a library in early February 1967. The Institute moved to the Arap Deresi neighborhood in the second half of the academic year of 1968-1969.
The first classroom in the end of the hall of the second floor in A Block was allocated as the library. In October 1977, the Library was moved to the ground floor of A block’s adjoining building. Finally, it was moved to its new three-story modern building in August 1994.
BOOK COLLECTION:
While the majority of the collection in the library is related to the Religion of Islam, there are also works in art, history, literature, economics, philosophy, sociology, psychology and so on. We have approximately 52,000 books in our collection.
Our library, which seeks to present information access to its users in the fastest and most accurate way, has also provided the opportunity to access the resources through internet in order to make the research of the users more efficient by systematically transferring the citation information of all the publications in the collection to the computer environment within the rules of librarianship.
Manuscripts:
We have 389 manuscripts in our library collection.
PERIODICAL PUBLICATIONS:
There are 11 subscriptions to printed outsourced magazines, and 24 Turkish magazines (donations and purchases) in our library.
Our library is open at lunch breaks, closed on weekends and official holidays.
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The Library’s Physical Area: Total 1090 m2, three-story modern library building. In the upstair, 88-seat reader lounge with reference books; Middle-level bureaus and the dedicated field for the sources of Core Islamic Sciences; The ground floor has elevator and staircases, periodical publications, and a lounge for the departments other than the Core Islamic Sciences.
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ISLAMIC TERRORISM AND RELIGIOUS PERSECUTION
Lee Jay Walker – radical Islam & terrorism
About Lee Jay Walker
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Posts tagged ‘eugene robinson and robert spencer’
Anders Behring Breivik: media spin and hypocrisy in the name of Islamic Sharia law
Lee Jay Walker
Homosexuals hanged under Islamic Sharia law in Iran
Many individuals and writers who are rather timid in responding to homosexuals being hanged in Iran, amputations in Saudi Arabia for minor crimes, raped women being stoned to death in Somalia and then linking this with Islamic Sharia law, appears to be not on their agenda. However, the same writers who ignore this then link one individual called Anders Behring Breivik in order to lambast Robert Spencer, Pamella Geller and a host of other writers or organizations who support democracy. However, the same individuals fail to link either Islamic institutional discrimination which kills apostates in the name of Islam or when individuals did September 11 and stated openly that it was their Islamic duty.
Eugene Robinson, Opinion Writer at the Washington Post, is just one of the multitudes of hypocrites. Did the same Eugene Robinson put emphasis on Muslim religious leaders who said that “Islam is a religion of peace” after September 11?
Also, Osama bin Laden was clearly inspired by the Koran and Hadiths and if Eugene Robinson and the same so-called progressives are going to imply the same logic; then do they support pressure being put on people who read the Koran and support Islamic Sharia law?
Yes, many individual Muslim religious leaders may support peace but institutional discrimination in accordance with the teaching of Islamic Sharia law is a fact in many Islamic nations which are ruled by Islam.
Minority Muslim groups like the Alevi in Turkey and Ahmadiyya in Pakistan face Sunni Islamic persecution and if Sunni Islam took power in Syria then the Alawites have much to fear. Muslims are not a monolith and many individuals will think differently just like Buddhists, Christians, Hindus and non-religious people. However, Islamic Sharia law is a monolith and it threatens non-Muslims and moderate Muslims like the Ahmadiyya.
Eugene Robinson and a multitude of so-called progressive writers who are now lambasting democrats who understand the threat of global Islamic jihad desire to apply one rule. This applies to hypocrisy and ignoring the greater terrorist threat which kills frequently in nations like Afghanistan, Iraq, Pakistan, Somalia, Thailand and other nations.
If Eugene Robinson and others are trying to silence Robert Spencer, Pamela Geller, and a host of others; then what about the multitude of Islamic terrorist attacks whereby non-Muslims and minority Muslim groups are being killed and sometimes beheaded by the followers of radical Sunni Islam……will Eugene Robinson and other so-called progressives denounce Islamic religious leaders who are inciting violence based on the Koran and Hadiths?
Eugene Robinson and the so-called progressives are so politically correct that it makes you wonder what planet they reside on. After all, in modern day Saudi Arabia all Sunni Muslim apostates face the threat of death and not one single Buddhist temple, Christian church or Hindu temple is allowed.
Shia Muslims are also treated like second-class citizens in Saudi Arabia and clearly the Shia face massive discrimination in Bahrain, Yemen, and other Sunni Muslim dominated nations. Even in moderate Malaysia the Shia faith is illegal and Sunni Muslim converts to Shia Islam face persecution.
Other Islamic nations implement the death penalty for apostasy but can Eugene Robinson mention one non-Muslim nation in the modern world which supports killing apostates?
Of course religious discrimination exists in other nations but we are talking about killing apostates or the death penalty for non-Muslim men for marrying a Muslim female. Which non-Muslim nation allows this under its legal code?
In Iran two young homosexuals were hanged and remember apostates and homosexuals are not being killed by deranged individuals who kill innocents, which was the case in Norway whereby Anders Behring Breivik massacred innocent individuals and who will pay for his evil crime against humanity.
On the contrary, Islamic Sharia law is killing these homosexuals and apostates because of state sanctioned discrimination which is based on the Koran and Hadiths. Also, just imagine, what do you think would happen to a Buddhist/Christian/Hindu male who married a Muslim female in Saudi Arabia?
Yes, for an act of love the Buddhist/Christian/Hindu male would face the death penalty. Again, note that they would be killed for committing no crime apart from being deemed subhuman under the legal code of Islamic Sharia law.
This hatred is institutional therefore innocents in some Islamic nations which are based on Islamic law are punished or killed for acts of love or thinking freely. Also, while Islamic religious leaders in these nations continue to support hatred, bigotry, and rampant discrimination by quoting from the Koran and Hadiths; it is abundantly clear that some Islamists believe that one day they will subvert democratic nations and install this hatred.
Eugene Robinson should also note that while every single Muslim apostate to Christianity faces being killed in Somalia it is not a distant problem. Therefore, maybe Eugene Robinson and other so-called progressives believe that killing African Christians in Somalia or homosexuals in Iran is fine or not a problem because the country is distant?
After all, when two million African Animists/Christians/Muslims were being killed by the Arab regime in Khartoum I don’t recall the trendy brigade in the United Kingdom saying much. Instead it was all about Israel and even the enslavement of Africans in Sudan did not raise much of a shout and today African Muslims in Darfur still face the threat of Arabization.
However, radical Islamists from Somali backgrounds in America and the United Kingdom have actually gone back to Somalia in order to spread Islamic jihad and install Islamic Sharia law. Therefore, Christians are being beheaded and a raped girl was stoned to death but these barbaric ways are being supported by elements within the Somali community in America and the United Kingdom – this blows away the assimilation theory of Eugene Robinson and surely he understands what Islamic kitman means?
Irrespective of what people may think about Robert Spencer or Pamela Geller they both support democracy, liberty, and the rule of law whereby all individuals are equal.
Is Eugene Robinson going to claim that Islamic Sharia law supports equality and that the testimony of a non-Muslim is equal in court cases involving a non-Muslim and a Muslim? Is Eugene Robinson going to link the Koran and Muslim religious leaders who have incited violence against non-Muslims and minority Muslim groups? Is Eugene Robinson going to stand up and denounce institutional hatred against homosexuals who face the death penalty and state that this hatred is inspired by Islamic law? Is Eugene Robinson going to stand up against Islamic Sharia based nations which support killing non-Muslim men for merely marrying a Muslim female?
It is abundantly clear that Islamic Sharia law, the Hadiths and the Koran support massive discrimination against non-Muslims. Therefore, the so-called progressives like Eugene Robinson appear to be sleep-walking or they are being extremely selective.
The simple reality is that Anders Behring Breivik will be locked away for the evil he did. However, when women are being stoned to death, homosexuals are being killed and apostates face the death penalty; all this is being done in accordance with Islamic Sharia law.
This is state sanctioned hatred in the name of a religion which does not tolerate equality when in power. Therefore, why are Eugene Robinson and the rest of the so-called progressives so noisy about one deranged individual with no political power but then say little about the daily reality of nations like Saudi Arabia?
Also, note the “Islamic victim card” once more but clearly nearly everyone killed by Anders Behring Breivik were either Christian or secular.
Not that it matters who Anders Behring Breivik killed because his actions were pure evil and he should never see the outside world again. In Norway non-Muslims and Muslims are equal in law unlike the institutional discrimination of nations like Saudi Arabia.
Clearly, the sad fact is that Anders Behring Breivik is being brushed aside by so-called progressives and instead it is an opportunity to attack individuals who are democratic and support liberty.
More important why the clear double-standards and not only this, what about progressives boycotting goods from Saudi Arabia because of state institutional hatred whereby apostates face the death penalty and homosexuals also face the same brutal system. This is all being done under Sharia Islamic law.
Clearly, this will never happen because of energy factors but progressives should not concern themselves with the motives of capitalists. Also, is Eugene Robinson going to claim that the Koran and Hadiths did not inspire the individuals who did September 11 and that state institutional hatred towards all non-Muslims and homosexuals in Saudi Arabia is not based on the Hadiths, Koran and Sharia Islamic law?
THIS ARTICLE IS BASED ON THE LINK BELOW
http://www.washingtonpost.com/opinions/anders-behring-breivik-and-the-influence-industry-of-rage/2011/07/25/gIQASd2WZI_story.html
These links either show discrimination or the nature of Islamic Sharia law
http://somalisforjesus.blogspot.com/2009/01/mansur-mohamed-sfj-martyr-of-year-2009.html – Islamists beheading a convert from Islam to Christianity.
http://news.bbc.co.uk/2/hi/7708169.stm – Raped woman stoned to death in Somalia
http://www.bbc.co.uk/news/10190389 – Massacre of Ahmadiyya Muslims
http://news.bbc.co.uk/2/hi/middle_east/1992027.stm – Amputations and flogging in Saudi Arabia
http://www.dw-world.de/dw/article/0,,5417393,00.html – Persecution of the Alevi
http://www.dw-world.de/dw/article/0,,5417393,00.html – Islamic groups who hate the United Kingdom
http://www.timesonline.co.uk/tol/news/world/middle_east/article2859606.ece – Iran Minister supports killing homosexuals and based on Islamic Sharia law
http://moderntokyotimes.com
https://islamicpersecution.wordpress.com
Posted in EUROPE, ISLAMIC TERRORISM, PERSECUTION OF CHRISTIANS, Uncategorized | Leave a Comment »
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Alija Izetbegovic and radical Islam CIA and Islamic terrorism dhimmitude http://global-security-news.com http://islamicinquisition.wordpress.com https://islamicpersecution.wordpress.com http://leejaywalker.wordpress.com http://moderntokyotimes.com International relations Islam islam and hatred islamic inquisition islamic inquisition is ongoing islamic jihad Islamic sharia law Islamic sharia law and dhimmitude Islamic terrorism islamic zealots killing apostates in Islam killing christians in somalia killing in the name of allah killing in the name of islam Koran inspires hatred Lee Jay Walker modern tokyo times mohammed and hatred mohammed married a child Mohammed supported killing apostates Murad Makhmudov and Lee Jay Walker persecution of Ahmadiyya Muslims radical islam Radical Islam in Bosnia radical Islam in the Balkans radical sunni islam stealth jihad sunni islamic fanatics sunni islamic fascism sunni islamic hatred sunni islamic jihad sunni islamic terrorism sunni islamic zealots The Revenge of the Prophet by Vojin Joksimovich Vojin Joksimovich and Bosnia Vojin Joksimovich and terrorism Zachary Abuza highlights islamic terrorism in southeast asia
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Home / Tag Archives: prince
Tag Archives: prince
Lineup for Prince tribute revealed
1 week ago Uncategorized 0
More than a dozen starrings will take the stage to perform in honor of musical legend Prince later this month, the Recording Academy announced in a news release. Read more: cnn.com
Prince George scores the Duchess of Cambridges’s Chelsea Flower Show garden 20 out of 10 – Daily Mail
May 22, 2019 Uncategorized 0
Prince George ratings the Duchess of Cambridges’s Chelsea Flower Show garden 20 out of 10 Daily MailKate Middleton supported by Prince William, Sophie Wessex and the Queen at Chelsea Flower Show – best videos HELLO! Chelsea Flower Show: When does the flower show end? How long is it on for …
13 Fun Facts About Harry and Meghan’s Wedding That Will Make You Feel Like You Were There
Prince Harry and Meghan Markle tied the knot in a romantic ceremony at St. George’s Chapel at Windsor Palace on May 19, 2018. The extravagant nuptials brought forward the couple’s nearest and dearest including Meghan’s mom, Doria Ragland, and Kate Middleton, Prince William, Prince George, Princess Charlotte, and Princess Diana’s …
Meghan Markle’s dad says she has a ‘pained smile’ — and he’s worried she’s buckling under the pressure
July 17, 2018 Uncategorized 0
Michael Steele / Getty Images Thomas Markle has spoken out against the royal family in another controversial interview. Speaking to The Sun, Markle said his daughter, the Duchess of Sussex, looks terrified in her new role and said she has a “pained smile.” Markle is considering coming to the UK …
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Announcing… April as the Delicious Food Month in Manila
Article By: Anton Diaz
The entire month of April is officially the delicious Food Month in Manila which opens with Madrid Fusion Manila and culminates with the World Street Food Congress at April 9 and 16.
An International Culinary Event you would not want to miss.
Madrid Fusion Manila (MFM) is the first and only Asian edition of Madrid Fusion, the most important international gastronomy congress in the world, celebrated annually in Madrid since 2003. MFM brings together the most acclaimed avant- garde chefs from across the globe. On its first year, the theme of the congress was ‘The Philippines and Spain: A 300-year Gastronomic Journey.
In 2016 , in celebration of the 450th anniversary of the Galleon Trade that linked Asia with the Western World, the theme of Madrid Fusion Manila 2016 will be ‘The Manila Galleon: East Meets West’, expanding the gastronomic conversation further, not only between two countries but between two very different parts of the world.
The brandchild of heritage and street food maven KF Seetoh of Makansutra, the WSFC was created in 2013 largely to capitalise on all the relevant aspects and opportunities of heritage street food culture around the world. It seeks to address three most pressing points of this culinary Street Food culture which serves to be the Pillars of the event:
https://www.ourawesomeplanet.com/a wesome/2016/04/april-delicious-food- month-manila-1.html
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- Select -HomeAboutPodcastContact
#063 – Ryan Bickle: Beers & Butterflies | Forking Around Costa Rica
Ryan Bickle of Butterfly Brewing Company
I had quite the adventure with Ryan Bickle, the owner and master brewer of Butterfly Brewing Company, a “hill-top jungle-brewery-butterfly-garden by the sea.”
The garden and nanobrewery are located in Montezuma, Costa Rica, on the southern tip of the peninsula. The beers are just forking delicious, but if that isn’t enough, you can enjoy them while taking in the view of countless neotropical butterflies. And if you want to see the place, you can check out the videos I took on Facebook: facebook.com/debi.saltzberg!
“We just want to make better beer at an affordable price. It has nothing to do with wanting to be a millionaire or having a Mercedes Benz on these dirt roads… you want to be successful though, and you want to have fun!” –Ryan Bickle
We also discuss:
Howler monkey balls
Touring the garden & caterpillar lab
The 17 different species of passion fruit
Setting up the brewery 13 years ago
Importing ingredients & equipment
Moving from Oregon to Costa Rica
Ryan’s brewing equipment & process
Learning how to brew
The most difficult part of running this business: paying taxes
Learn more about Butterfly Brewing Co.: https://www.montezumagardens.com/deals-and-tours
Check out the awesome videos I took on Facebook: facebook.com/debi.saltzberg
Want to increase sales & improve service in your restaurant? Get 20% off TouchBistro at touchbistro.com/justforkingaround
Get 15% off your supplements by using discount code “JustForkingAround” at OraOrganic.com
Ryan Bickle’s Bio:
Ryan Bickle was born on the 6th of March, 1981. He grew up in Pullman, WA, a small college town in South Eastern part of Washington State, surrounded by rolling hills of wheat and barley.
At the age of nineteen, he moved to Portland, OR and quickly became a craft beer fanatic and IPA lover.
A passionate traveler and constant dreamer, Ryan traveled all around central America from 2000 to 2004 and fell in love with Costa Rica. He later convinced his family to invest in Costa Rica and eventually bought his property in 2005.
In December 2005 Ryan opened Mariposario Montezuma Gardens, a Bed and Breakfast and butterfly garden.
In 2012, Ryan officially started Butterfly Brewing Co., where they now make 8 different craft beers and 4 different craft sodas. In 2015, Ryan teamed up with a couple from Costa Rica/Oregon and started Cocina Clandestina, where you can find all of his beers and sodas on tap.
Debi Saltzberg
I love the world of food and beverage, everything about it, it’s soo damn sexy! Every time we eat and drink it ignites us sensually…the look, texture, taste, smell, sound all in a unique combination, encapsulating a moment in time. The act of sharing a meal with friends, chatting, eating, and drinking together is so forking perfect. It is a feeling that echoes a sense that All Is Good! Very, Very good!
https://justforkingaround.net
Search All Episodes
View all episodes here
© 2018 Forking Around All Rights Reserved
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James Begley
Entrepreneur and Leadership Expert
Rooster Radio Podcast
James and AFL champion Matthew Pavlich joined forces to launch PickStar, a marketplace allowing Australians to engage sporting stars for their events and promotions, while enabling high profile athletes to connect with the community.
In just two years the platform has already facilitated more than 400 events and has a database of over 600 athletes. Not content with early success, James is now preparing to lead PickStar to a new level of growth. Download the PickStar presentation.
TRACT Group was born in the cauldron of elite sport. James Begley and Jason Weber have combined to produce a business that inspires people and measures business. TRACT Group utilizes the unpretentious, direct and challenging philosophies implemented widely in the AFL and international rugby communities.
James Begley has a passion for delivering simple, direct and inspiring organizational development workshops. James has a record for improving team alignment, staff engagement, peer to peer feedback and team cohesiveness. He played professional Australian Rules Football for The Adelaide Crows and St Kilda Football Club for 7 years. James has delivered leadership and development programs to Mirvac, Landcorp, Synergy, Local Government Superannuation, Fonterra, AHG and the Fremantle Football Club. He has over 10 years of corporate and elite sporting facilitation experience.
Connect with James
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Tag Archives: The Good Project
Review of Monica Krause’s book “the Good Project Humanitarian Relief and the Fragmentation of Reason”
Posted on October 17, 2018 by janoschkullenberg
In my research, I use a Bourdieu-inspired theoretical framework to understand why international protection actors interact the way they do. While much of the recent ethnographic literature on the aid world has shed light on every day practices of intervention and is therefore helpful for understanding how organizations function, the descriptions often remain on the micro level. Bourdieu’s theoretical framework requests a similar empirical focus but pushes for reconstructing a more holistic picture of the system and why it functions in the described ways. Similarly, I found much of the organizational theory unsatisfying because it only explains part of the picture. For instance, most organizational behavior is explained by interests, which are generally assumed to be pre-existing and stable. Interest-based frameworks do not offer answers to one of my central puzzles, which is: how do aspiring aid workers, with all their idealism, turn into interest-focused strategists? In contrast, Bourdieu brings rational and sociological factors together in a way that allows for incorporating the different explanations from organizational theorists into one more holistic framework. An added value of his work is the skillful articulation of the interaction between structure and agency.
Empirically, Bourdieu’s focus on power and competition breaks with the self-description of the aid world and offers insights beyond its harmonious rhetoric. Although the concept of “symbolic capital” first appears abstract, it is particularly useful for understanding what keeps the aid world up and running. Arguably, legitimacy is particularly important for Aidland, which explains many of the sector’s schizophrenic tendencies, such as the tensions between elevated moral claims and constant under-achievement. However, grappling with Bourdieu’s concepts can be challenging (in its freedom) and bears the risk of over-theorizing. He sketches his theoretical underpinnings only briefly over a number of relatively inaccessible publications. While there exist a large amount of useful secondary literature, I remained unsure if it is indeed the most accurate framework for capturing the “field” of humanitarian intervention and whether I really need the theory to describe the empirical reality. Hence, other applications of Bourdieu’s theory are of particular interest to my work.
Monika Krause’s 2014 book “The good Project: Humanitarian Relief NGOs and the Fragmentation of Reason” represents one of the most consequential and strongest applications of Bourdieu’s theory to the aid world (a strong contender being Catherine Goetze’s more recent “Distinction of Peace”). Contrary to other analysts of “Aidland”, such as Lisa Smirl and Séverine Autesserre, Krause is a sociologist who has not worked for NGOs or the UN and who has conducted much more limited fieldwork. Instead she has a stronger theoretical focus, which she applied to produce a rare system-level analysis of the aid world. However, the strength of this book is not its solid theoretical foundation but the insights they lead to: a revealing description of how the aid world functions and why it functions that way. While other authors are stronger in depicting the everyday practices of the sector, Krause’s holistic picture of the aid world is very convincing. For instance in chapter two, when she not only argues but explains why donors – and not beneficiaries – are at the center of organizational priorities; and why, in fact, beneficiaries have become a commodity in the project cycle.
The basic premise of the book is that humanitarianism is a distinct field of practice, in which NGOs share basic assumptions and a common practical logic. This logic developed historically and is shaped by the structural conditions of the field. In return, the practical logic “mediates” factors such as problems, needs, values and interests into organizational action (p.21). The author argues that these practices are “practices of production” and that their primary product is the “project” (p.23). The logic of project management is the taken-for-granted way things are done in humanitarian relief. Its focus on added value – what Krause calls “the pursuit of the good project” – creates a logic that shapes the allocation of resources and the development of activities independently from what recipients may want or need (p.37).
On this part of the argument, there is wide agreement. Neo-institutionalists, such as Meyer & Rowan and DiMaggio & Powell stress the shared cultures and norms in an organizational field as well as actors’ orientation towards legitimacy. However, Bourdieu’s original thought reaches further. In chapter four, Krause argues that humanitarian organizations are not only similar, but actively seek to differentiate themselves from each other (p.93). The reason for that is that the ‘field’ is organized around specific forms of symbolic capital and humanitarian agencies look at each other, rather than looking at the abstract market or the customers (p.98). Accordingly, humanitarian relief is primarily shaped by competition for symbolic capital, which Krause identifies to be ‘humanitarian authority’. As each field has developed in a unique manner, Krause then describes the history of the humanitarian field and the emergence of its specific symbolic capital. Unsurprisingly, the ICRC features prominently as the embodiment of humanitarian authority. Krause accurately summarizes: “In its pure form, humanitarianism is humanitarianism for humanitarianism’s sake” (p.113). But this purity is nowadays “polluted” by political, religious and other aspects. Interestingly, Krause argues that the foundation of MSF and its challenge against the “traditional” way of being humanitarian, established the field of competing positions. “MSF’s innovation, though it had ‘purity’ on its flags, clearly formulated an alternative to the ICRC, and so called into question the foundations of the (humanitarian) enterprise” (p.107). Simply put, “MSF’s move made it easier for a range of other actors to claim the label ‘humanitarian’” (ibid) and, therewith facilitated the expansion of the field in the nineties.
Despite the intellectual depth of the book, it does not come across as theoretical or pretentious. The work is very theoretically informed without ever really confronting the reader with dense concepts. Instead, Krause speaks mainly about empirical reality in an accessible way. This makes it a great read and probably less vulnerable to push-back from ‘Aidland’, which would be expected (if its inhabitants read Krause’s book). While other authors have made similar observations and came to the conclusion that flawed practices should be improved, Krause takes her analysis of the field as the basis to also explore the actors’ reform efforts in chapter five. Specifically, she investigates the Sphere Project and Humanitarian Accountability Project (HAP), concluding that their impact is ”mediated by existing practices and institutions” (p.145). Accordingly, both “have become incorporated into the process of producing projects, and with their respective standards shape specific products and add to the infrastructure of the market for projects” (ibid). This judgment is another instance of great courage and consequentialism.
Another virtue of the book is that it makes the most out of comparatively modest methodological means. Krause mainly bases her analysis on a limited sample of interviews with desk officers and directors of operations at headquarters level but was able to infer a whole lot from these conversations. Particularly memorable is the chapter on management tools. Krause participated in a training for relief workers where she was confronted with the ‘logframe’. While everyone else was naturally familiar with the tool, Krause was clueless and took it on her to study this artifact. She come to the conclusion that “management tools like the logframe do not determine what people do, but they shape it: They shape what people get to see and know about the world, and people’s ideas about what the task before them is” (p.76). She argues that historically the logframe has facilitated the project as a unit of planning and production. “It has linked results to costs, and it thus made it possible, in principle, to compare projects” (p.77). The logframe also “created the beneficiary” as the specific part of the population in need that is selected to be served (ibid).
Having outlined in the introduction that I am convinced by the approach (so much in fact that I have independently chosen a similar one) and praised the book sufficiently, some criticism is in order. I have two interrelated points: First, I am wondering why she only researched and wrote about NGOs with the omission of the UN organizations. UNHCR, WFP and OCHA are also major relief organizations and together the UN entities are the biggest actor and a major agenda setter for the field. Leaving them outside the analysis might distort the picture.
Second and more generally, I am doubtful whether the pure humanitarian field still exists in practice. Through the constant broadening of mandates and proliferation of new actors, Humanitarianism, Development, Human Rights and Peacekeeping have increasingly blurred together in something like a larger field of ‘international intervention’. They overlap in regards to their principals, beneficiaries, mandates, activities, etc. The author alludes to this in regards to ‘protection’ in chapter six, where she writes about the field of human rights and its relation to relief work. This is maybe the only part of the book where Krause is not consequential enough. Particularly protection – the focus of my own work – no longer falls within one separate field but rather seems to be a discourse in the larger field of international intervention. Separating the humanitarian field cleanly from this complex is to some degree possible and useful to distill the essence of humanitarian symbolism. However, it is of limited practical value. Humanitarian authority remains an important form of (symbolic) capital but it is no longer the main currency. I am wondering if one can capture the norms, games and symbolic capital of this field accurately, when only looking at the humanitarian sub-dimension. In practice it is messier, more complicated, but perhaps still ordered and understandable. I would thus argue for continuing where Krause stops – taking a closer look at protection as an intersection of different fields or as a discourse in a larger field of international intervention, and then working towards distilling the symbolic capital and practical logic of that larger field.
Posted in Uncategorized | Tagged Aidland, Anthropology of Aid, Book Review, Bourdieu, Field, Monika Krause, The Good Project | Leave a reply
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PLOS Neglected Tropical Diseases is the top Open Access tropical medicine journal, featuring an International Editorial Board and increased support for developing country authors.
Commitment To Capacity
Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy
Zhiru Li,
Affiliation New England Biolabs, Division of Parasitology, Ipswich, Massachusetts, United States of America
Amanda L. Garner,
Affiliation Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute for Research and Medicine, The Scripps Research Institute, La Jolla, California, United States of America
Christian Gloeckner,
Kim D. Janda,
Clotilde K. Carlow
* E-mail: carlow@neb.com
https://doi.org/10.1371/journal.pntd.0001411
Zhiru Li Amanda L. Garner ... Clotilde K. Carlow
The use of antibiotics targeting the obligate bacterial endosymbiont Wolbachia of filarial parasites has been validated as an approach for controlling filarial infection in animals and humans. Availability of genomic sequences for the Wolbachia (wBm) present in the human filarial parasite Brugia malayi has enabled genome-wide searching for new potential drug targets. In the present study, we investigated the cell division machinery of wBm and determined that it possesses the essential cell division gene ftsZ which was expressed in all developmental stages of B. malayi examined. FtsZ is a GTPase thereby making the protein an attractive Wolbachia drug target. We described the molecular characterization and catalytic properties of Wolbachia FtsZ. We also demonstrated that the GTPase activity was inhibited by the natural product, berberine, and small molecule inhibitors identified from a high-throughput screen. Furthermore, berberine was also effective in reducing motility and reproduction in B. malayi parasites in vitro. Our results should facilitate the discovery of selective inhibitors of FtsZ as a novel anti-symbiotic approach for controlling filarial infection.
The nucleotide sequences reported in this paper are available in GenBank™ Data Bank under the accession number wAlB-FtsZ (JN616286).
Filarial nematode parasites are responsible for a number of devastating diseases in humans and animals. These include lymphatic filariasis and onchocerciasis that afflict 150 million people in the tropics and threaten the health of over one billion. The parasites possess intracellular bacteria, Wolbachia, which are needed for worm survival. Clearance of these bacteria with certain antibiotics leads to parasite death. These findings have pioneered the approach of using antibiotics to treat and control filarial infections. In the present study, we have investigated the cell division process in Wolbachia for new drug target discovery. We have identified the essential cell division protein FtsZ, which has a GTPase activity, as an attractive Wolbachia drug target. We describe the molecular characterization and catalytic properties of the enzyme and demonstrate that the GTPase activity is inhibited by the natural product, berberine, and small molecule inhibitors identified from a high-throughput screen. We also found that berberine was effective in reducing motility and reproduction in B. malayi parasites in vitro. Our results should facilitate the discovery of selective inhibitors of FtsZ as a novel antibiotic approach for controlling filarial infection.
Citation: Li Z, Garner AL, Gloeckner C, Janda KD, Carlow CK (2011) Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy. PLoS Negl Trop Dis 5(11): e1411. https://doi.org/10.1371/journal.pntd.0001411
Editor: Sara Lustigman, New York Blood Center, United States of America
Received: September 20, 2011; Accepted: October 19, 2011; Published: November 29, 2011
Copyright: © 2011 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by New England Biolabs. ZL and CKC are employees of New England Biolabs; this funder is therefore considered by PLoS Neglected Tropical Diseases to have played a role in study design, data collection and analysis; however, the authors confirm that the funder did not play a direct role in the study.
Competing interests: ALG, CG and KDJ declare no conflict of interests. ZL and CKC are employees of New England Biolabs. The authors' affiliation with the funder does not alter their adherence to all the PLoS Neglected Tropical Diseases policies on sharing data and materials.
Filarial nematode parasites are responsible for a number of devastating diseases in humans and animals. These include lymphatic filariasis and onchocerciasis that afflict 150 million people in the tropics and threaten the health of over one billion. Unlike other nematodes, the majority of filarial species are infected with an intracellular bacterium, Wolbachia [1]. In the human filarial nematode Brugia malayi, these obligate α-proteobacterial endosymbionts have been detected in all developmental stages [2]–[4]. Moreover, their presence is essential for the worm, as tetracycline-mediated clearance of bacteria from Brugia spp. leads to developmental arrest in immature stages and reduction in adult worm fertility and viability [5]–[10]. These findings have pioneered the approach of using antibiotics to treat and control filarial infections. However, in humans, tetracycline therapy is not ideally suited for widespread use because several weeks of treatment are required and the drug has contra-indications for certain individuals. Therefore, there is considerable interest in identifying new endosymbiont drug targets and other classes of compounds with anti-Wolbachia activity. Importantly, the completed genome sequence of the Wolbachia endosymbiont of B. malayi (wBm) [11] now enables genome-wide mining for new drug targets [11]–[14] and a foundation for rational drug design. These approaches should lead to the discovery of new classes of compounds with potent anti-Wolbachia/antifilarial activities targeting essential processes that are absent or substantially different in the mammalian host.
Bacterial cytokinesis has emerged as a major target for the design of novel antibacterial drugs [15]–[17] since several of the components that are essential for multiplication and viability are absent from mammals. The bacteria-specific “filamenting temperature sensitive” protein, FtsZ, plays a central role during bacterial cytokinesis. In Escherichia coli, temperature sensitive mutations in the ftsZ gene cause blockage in cell division with limited cell growth and the generation of long filaments. FtsZ assembles into the contractile Z-ring and coordinates more than a dozen other cell division proteins at the midcell site of the closing septum [18]–[21]. Formation of the septal Z-ring requires two important functional properties of FtsZ, namely, polymerization of the FtsZ monomers into protofilaments and GTPase activity. Since inhibition of either function is lethal to bacteria, both GTP-dependent polymerization [22]–[27] and enzymatic [27]–[28] activities of FtsZ have been targeted for the identification of new antibacterial agents. Several inhibitors have been discovered including synthetic compounds [17], [29] and natural products [17], [30]–[33].
In the present study, we identify the cell division machinery present in wBm and characterize the FtsZ protein (wBm-FtsZ). Using quantitative real time RT-PCR, Wolbachia ftsZ was found to be expressed throughout the life cycle, but up-regulated in fourth stage larvae and adult female worms. Recombinant wBm-FtsZ was shown to possess a robust GTPase activity, which was inhibited by the natural plant product berberine. Berberine was also effective in reducing motility and reproduction in B. malayi parasites in vitro. A library of small molecules was also examined for its inhibitory activity against the wBm and E. coli FtsZ proteins. Several compounds were identified as potent inhibitors, and structure-activity relationship studies revealed a derivative with selectivity for wBm-FtsZ. Thus, our results support the development of wBm-FtsZ as a promising new drug target in an anti-symbiotic approach for controlling filarial infection.
Cloning of ftsZ from the Wolbachia endosymbiont of the human filarial parasite B. malayi (wBm-ftsZ)
Living B. malayi adult female worms were purchased from TRS Laboratories, Athens GA. Genomic DNA and RNA were isolated following the protocols developed by Dr. Steven A. Williams (http://www.filariasiscenter.org/molecular-resources/protocols).
To clone full-length wBm-ftsZ for expression studies, forward 5′(GAGAGCTAGCATGTCAATTGACCTTAGTTTGCCAG)3′ (NheI site underlined) and reverse 5′(GAGACTCGAGTTACTTCTTTCTTCTTAAATAAGCTGG) 3′ (XhoI site underlined) primers were designed according to the wBm-ftsZ sequence (accession number: YP_198432) in order to amplify the gene from B. malayi genomic DNA. The PCR product was then cloned into the NheI and XhoI sites of pET28a(+) (Novagen) to generate a fusion protein with a His6 tag at the N terminus. The authenticity of the insert was verified by sequencing.
Wolbachia ftsZ gene expression in various developmental stages of B. malayi
Total RNA supplied by the Filariasis Research Resource Center (FR3) was treated with RNase-free Dnase (New England Biolabs, Cat# M0303S) and purified using the RNeasy Kit from Qiagen. cDNA was obtained using random primers and the ProtoScript® AMV First Strand cDNA Synthesis Kit (New England Biolabs, Cat# E6550S). Forward primer 5′ (AACAAGAGAGGCAAGAGCTGGAGT) and reverse primer 5′(CGCACACCTTCAAAGCCAAATGGT) were utilized to amplify a 102 bp Wolbachia ftsZ amplicon. Wolbachia 16S rRNA amplified with forward primer 5′ (TGAGATGTTGGGTTAAGTCCCGCA) and reverse primer 5′(ATTGTAGCACGTGTGTAGCCCACT) was utilized for bacterial total RNA quantification. B. malayi 18S rRNA amplified with forward primer 5′ (ACTGGAGGAATCAGCGTGCTGTAA) and reverse primer 5′(TGTGTACAAAGGGCAGGGACGTAA) was utilized as a total worm RNA control. Quantitative PCR was performed using the DyNAmo™ HS SYBR® Green qPCR Kit (Thermo Fisher) and a CFX-96 Real Time PCR instrument (Bio-rad, Hercules, CA). Relative levels of ftsZ expression (ratio of ftsZ to 16S rRNA), and abundance of Wolbachia in B. malayi (ratio of Wolbachia 16S to B. malayi 18S rRNA) were calculated for each RNA sample. Experiments were performed twice with triplicate samples. Controls consisting of samples processed in the absence of reverse transcriptase were included in qPCR and no DNA contamination was detected.
Identification and cloning of FtsZ from the Wolbachia endosymbiont of Aedes albopictus
To determine the sequence of the ftsZ gene from the Wolbachia endosymbiont wAlB present in the insect cell line Aa23 [34], multilocus sequence typing (MLST) ftsZ forward 5′ (TGTAAAACGACGGCCAGTATYATGGARCATATAAARGATAG) and reverse 5′ (CAGGAAACAGCTATGACCTCRAGYAATGGATTRGATAT) [35] primers were utilized to obtain a PCR fragment. Using BLAST analysis, the sequence of the PCR product was compared to the corresponding region of known full-length ftsZ sequences and their conserved downstream and upstream sequences and 6 additional primers 5′(TCTATTTTTAATTCTTTTAGAGAAGCATT), 5′(CGTTCGGTTTTGAAGGTGTGC), 5′ (ACCGTTGTGGGAGTGGGTGGT), 5′ (TTATTTTTTTCTTCTTAAATAAGCTGGTATATC), 5′ (GGAATGACAATAAGTGTATCTACGTA), and 5′(TGCATTTGCAGTTGCTCATCC) were designed to obtain a complete wAa-ftsZ sequence. Phusion® High-Fidelity DNA Polymerase (New England Biolabs, M0530) was utilized for all PCR reactions according to manufacturer's instructions.
Expression and purification of recombinant Wolbachia FtsZ proteins
wBm-ftsZ and E. coli ftsZ (Ec-ftsZ) were amplified using genomic DNA isolated from B. malayi and E. coli wild-type strain MG1655 respectively, and were then cloned into the pET28a plasmid to generate fusion proteins with a N-terminal His tag. Each protein was expressed in the Escherichia coli strain C2566 (New England Biolabs). Optimum conditions for production of soluble recombinant wBm-FtsZ involved co-transformation with the pRIL plasmid isolated from BL21-CodonPlus (DE3) cells (Stratagene) together with the pET28a-ftsZ plasmid. Cultures were grown at 37°C till the OD600 reached 0.6, before induction with 0.1 mM IPTG overnight at 16°C. Both Ec-FtsZ and wBm-FtsZ were purified using a similar method. The cells expressing the recombinant proteins were suspended in lysis buffer (20 mM NaPO4, 500 mM NaCl, 10 mM imidazole, pH 7.4) plus 1 mg/mL lysozyme and protease inhibitor cocktail (Roche) and incubated on ice for 30 min, followed by sonication. The lysate was then cleared by centrifugation at 12,500 rpm, 4 °C for 30 min. The His-tagged proteins were purified on a 5 mL HiTrap chelating HP column (GE Healthcare) using an AKTA FPLC following manufacturer's instructions. After application of the sample, the column was washed with 5 column volumes of buffer A (20 mM NaPO4, 500 mM NaCl, 10 mM imidazole, pH 7.4) followed by 10 column volumes of 92% buffer A:8% buffer B (20 mM NaPO4, 500 mM NaCl, 400 mM imidazole, pH 7.4). Protein was then eluted using a linear gradient (8–100%) of buffer B equivalent to 40–400 mM imidazole.
Fractions containing wBm-FtsZ or Ec-FtsZ were pooled, dialyzed against dialysis buffer (40 mM Tris-HCl, 200 mM NaCl and 50% glycerol, pH 7.5) and stored at −20°C prior to use. Purity of the proteins was estimated by 4–20% SDS-PAGE and the protein concentration was determined using the Bradford assay.
GTPase enzyme assay
GTPase activity was measured using an enzyme-coupled assay [36]. Activity was determined by measuring the consumption of NADH, which is monitored by absorbance at 340 nm. The amount of NADH oxidized to NAD corresponds to the amount of GDP produced in the reaction. Reactions were optimized for a 96-well format to enable compound screening. The 100 µL reaction mixture containing 50 mM MOPS (4-morpholinepropanesulfonic acid) pH 6.5, 50 mM KCl, 5 mM MgCl2,1 mM PEP, 500 mM NADH, 0.1% Tween-20, 20 units/mL of L-lactate dehydrogenase (Sigma L2518) and pyruvate kinase (Sigma P7768), 1 mM GTP and 5 mM FtsZ was distributed into 96-well plates. The plate was incubated at 30 °C for 45 min with data collected at 20 second intervals using a SpectraMax® Plus 384 (Molecular Devices) spectrophotometer. Control assays without FtsZ were performed to provide a baseline and with GDP to ensure the function of the coupling enzymes.
For inhibitor screening, 100 µL of reaction mixture was added to each well of a 96-well plate and 1 µL of compound dissolved in DMSO, or berberine sulfate (MP Biomedicals) in water, in varying concentrations were added. The reaction was initiated at 30 °C by adding 1 mM GTP. Experiments were performed in triplicate.
Effect of berberine on B. malayi
Living B. malayi adult female and male worms were washed extensively with RPMI1640 medium supplemented with 2 mM glutamine, 10% Fetal Calf Serum (Gibco) and 100 U/mL streptomycin, 100 mg/mL penicillin, 0.25 mg/mL amphotericin B (Sigma). Three worms of either gender were distributed into each well of a 6-well plate and incubated at 37 °C, 5% CO2. After overnight recovery, motility and microfilaria production were recorded. Worms were then transferred to a new well containing varying amounts of berberine sulfate dissolved in water, namely 40 µM, 20 µM, 10 µM and 5 µM. Control wells containing either no drug or 10 µM doxycycline, were also included. Culture media were replaced with fresh medium containing drug daily. Adult worm and microfilaria motility production were recorded daily as described [37]. Motility was scored as described [38] and expressed as % of motility relative to motility scored on day 0 of the experiment. Microfilaria production was counted in 10 µL of either diluted or concentrated culture medium using a hemocytometer. The results were presented as the number of microfilaria released in 1 mL of medium from each well on the indicated day. Each treatment was performed in triplicate and the experiment was repeated several times.
Effect of berberine on E. coli growth
Berberine sulfate (MP Biomedicals) was added at a final concentration of 0–400 µM to growth medium containing E. coli ER1613 (acrA13 Δ(top-cysB)204 gyrB225 IN(rmD-rmE) mcrA) (New England Biolabs) and growth determined during 5 h or 20 h of incubation. For the 5 h evaluation, an overnight culture of E. coli ER1613 (acrA13 Δ(top-cysB)204 gyrB225 IN(rmD-rmE) mcrA) (New England Biolabs) was diluted 100-fold and 1 mL volumes were dispensed into a 48-well deep well plate (Axygen Scientific) containing various concentrations (0–400 µM) of berberine sulfate (10 µL of serial diluted berberine sulfate in water). The plate was then incubated at 30 °C with shaking. After 90 min of initial growth, bacterial growth was determined every 30 min for 5 h by monitoring absorption at 600 nm using a microtiter plate reader (Spectramax M5, Molecular Devices). Alternatively, an overnight culture of E. coli was diluted 1∶1000 fold and incubated with varying amounts of berberine sulfate for 20 h before growth was determined. All experiments were performed at least twice. Viability of berberine sulfate-treated (24 h) cells was evaluated by spotting 3 µL serial dilutions (10−2–10−7) of bacteria on a petri dish and incubation overnight at 30 °C.
Bacterial morphology was visualized using a Zeiss AxioVert 200 microscope and images were obtained using a 20× objective.
General chemistry methods for library synthesis
Reactions were carried out under a nitrogen atmosphere with dry, freshly distilled solvents under anhydrous conditions, unless otherwise noted. Yields refer to chromatographically and spectroscopically homogenous materials, unless otherwise stated. Reactions were monitored by thin-layer chromatography (TLC) carried out on 0.25-mm EMD silica gel plates (60F-254) using UV-light (254 nm). Flash chromatography separations were performed on Silicycle silica gel (40–63 mesh). Purity analyses were performed using HPLC (254 nm).
General synthetic procedure for library compounds
A stirring solution of aldehyde (1.0 equiv) in MeOH at 25°C was treated with carboxylic acid (2.0 equiv), amine (2.0 equiv) and isonitrile (2.0 equiv). The solution was heated to reflux, and stirred for 24 h. The solution was then cooled to 25°C and concentrated in vacuo. The crude residue was purified via flash column chromatography (10–50% EtOAc in hexanes) to afford the purified product. For characterization data, see references [39]–[40].
Genomic organization of the major cell division genes in wBm
The bacterial cell-division pathway has been extensively studied in E. coli and several essential proteins have been identified [17], [19]. Many of the genes encoding putative orthologs of these proteins are also present in wBm (Table 1). A total of 18 major cell division genes were identified in wBm genome (Table 1), including ftsZ, ftsA, ftsI, ftsK, ftsQ and ftsW, which are known to be essential for cell division [17]. These wBm genes were mapped and found to be more scattered throughout the genome, in comparison with their E. coli homologs. In E. coli the majority of genes were found in one major operon, with the remaining 5 genes distributed randomly. Of these, FtsZ was one of the most highly conserved essential proteins possessing 43% identity to Ec-FtsZ (Table 1). Wolbachia ftsA, ftsI, ftsK, ftsQ and ftsW were less related (13–34%) to the E. coli homologs. Some previously described essential cell division genes in E. coli (including ftsB, ftsL, ftsN and ZipA) were not found in wBm, indicating that there are differences in the cell division machinery present in free living E. coli and intracellular Wolbachia.
Table 1. Comparison of cell division machinery present in Wolbachia and E. coli*.
https://doi.org/10.1371/journal.pntd.0001411.t001
Sequence analysis of wBm-ftsZ
wBm-ftsZ exists as a single gene on the chromosome and is 1182 bp in length. It encodes a 394-amino acid protein with a predicted molecular mass of 42 kDa containing four distinct domains characteristic of FtsZ proteins. These comprise the variable N-terminal domain, a highly conserved core region, variable spacer, and a C-terminal conserved domain. The core region contains the highly conserved catalytic aspartate residue [41]–[42] and the GGGTGTGA motif (8 residues see [41], [43]), which are responsible for GTP hydrolysis and required for polymerization of the protein. The C-terminal region is not required for assembly, but is essential for interactions with the cell division proteins FtsA, FtsW and ZipA [17]. A similar organization was also found in the insect Wolbachia, wMel-FtsZ (NP_966481) and wAlB-FtsZ (JN616286). The FtsZ proteins of Wolbachia from different hosts share 89–91% identity and 43% identity to E. coli FtsZ proteins, with a substantially lower level at the carboxyl-terminal region (17.2% identity).
Analysis of wBm-ftsZ expression during the life cycle of B. malayi
Wolbachia have been identified in all developmental stages of B. malayi, from studies on individual worms and isolates from regions endemic for lymphatic filariasis [2]–[4]. To determine the relative expression of wBm-FtsZ throughout the parasite life cycle and validate its suitability as a drug target, wBm-ftsZ mRNA expression was analyzed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Relative levels of ftsZ expression (ratio of Wolbachia ftsZ to 16S rRNA) and abundance of Wolbachia in B. malayi (ratio of Wolbachia 16S to B. malayi 18S rRNA) were calculated for each RNA sample.
wBm-ftsZ was found to be expressed throughout all stages examined (adult female and male worms, microfilariae, third- and fourth-stage larvae). Moreover, wBm-ftsZ/16S ratios were found to be increased substantially following infection of the mammalian host since levels were significantly higher (p value<0.001) in fourth-stage larvae and adult female worms compared to the vector-derived infective third-stage larvae. The wBm-ftsZ/16S ratio was also higher in microfilariae compared with the vector-derived third-stage larvae, but was significantly lower than the ratios obtained for fourth-stage and adult female worms. Of the various developmental stages examined, the lowest level of wBm-ftsZ expression was found in male worms (Figure 1A). No DNA contamination was detected in controls consisting of samples processed in the absence of reverse transcriptase. Wolbachia 16S rRNA/B. malayi 18S rRNA ratios were also determined to measure the relative abundance of bacteria in different stages of B. malayi (Figure 1B). Wolbachia was found to be most abundant in fourth stage larvae and adult female worms and least abundant in infective third stage larvae, indicating a massive multiplication of Wolbachia soon after infection of the mammalian host. Taken together, these data indicate that while wBm-ftsZ is expressed in all stages, gene activity and bacterial multiplication is most pronounced in fourth-stage larvae and adult females.
Figure 1. Wolbachia ftsZ gene expression in various developmental stages of B. malayi.
Female adult worm, male adult worm, microfilaria, L3 and L4 were analyzed. The ratio of ftsZ to 16S rRNA (A) represents ftsZ gene expression, while the ratio of Wolbachia 16S to B. malayi 18S rRNA (B) represents the relative abundance of Wolbachia in B. malayi. The data obtained from triplicate samples are expressed as a mean ± standard deviation.
https://doi.org/10.1371/journal.pntd.0001411.g001
Expression and purification of recombinant wBm-FtsZ
Recombinant wBm-FtsZ was expressed in E. coli with a His-tag at the C-terminus and purified by nickel-affinity chromatography (Figure 2A). Optimum conditions for production of soluble recombinant wBm-FtsZ involved growth of cultures at 37°C until the OD600 reached 0.6, followed by induction with 0.1 mM IPTG overnight at 16°C. Purified protein was eluted with 100 mM imidazole. The apparent molecular weight of 43 kDa (Figure 2A) was consistent with the predicted molecular size of wBm-FtsZ with an N-terminal His-tag. For comparative studies, E. coli FtsZ (41 kDa) was also expressed and purified in a similar manner (Figure 2B).
Figure 2. Expression and purification of recombinant FtsZ proteins.
FtsZ protein from Wolbachia (A) and E. coli (B) were expressed in E. coli with a His-tag at the N-terminus and purified by nickel-affinity chromatography. The apparent molecular weight (indicated) from SDS–PAGE was consistent with the predicted molecular size. Protein marker (M), total protein lysate (T), insoluble proteins (In), soluble (S) and purified FtsZ proteins (P) are shown.
Recombinant wBm-FtsZ has GTPase activity
GTPase activity was measured using an enzyme-coupled assay involving pyruvate kinase and lactate dehydrogenase [36]. GTP hydrolysis was determined by measuring the decrease in fluorescence emission following oxidation of nicotinamide adenine dinucleotide (NADH) to NAD (Figure 3A). As Figure 3B shows, recombinant wBm-FtsZ was found to possess GTPase activity. Moreover, the specific activities for wBm-FtsZ and Ec-FtsZ were comparable (0.18±0.012 µmolµmin−1mg−1 and 0.22±0.015 µmol min−1mg−1, respectively).
Figure 3. GTPase activity of recombinant wBm-FtsZ.
Panel A, activity was determined indirectly by measuring a decrease in NADH concentration by its absorbance at 340 nm. FtsZ hydrolyzes GTP into GDP and inorganic phosphate. The GDP product is used as a substrate by pyruvate kinase (PK) in the presence of phosphoenol pyruvate (PEP) to yield GTP and pyruvic acid as products. Pyruvic acid is used as a substrate in the presence of NADH by lactate dehydrogenase (LDH) to generate lactate and NAD. The consumption of NADH is proportional to GTPase activity. Panel B, comparison of the GTPase activity of wBm-FtsZ and Ec-FtsZ. A control without enzyme was also included. Activity was indicated by a decrease of NADH measured by absorbance at 340 nm.
Inhibition of wBm-FtsZ GTPase activity using the plant alkaloid berberine
Berberine, an alkaloid natural product, is a known inhibitor of the GTPase activity of FtsZ in E. coli [33], [44]. Thus, we were interested in examining the generality of berberine's GTPase inhibitory activity against wBm-FtsZ. As Figure 4 shows, dose-dependent inhibition (25–1000 µM) was found with an IC50 value of 320 µM. E. coli FtsZ [33], [44] was included for comparison, and an IC50 value of 240 µM was observed (Figure 4). Since wBm-FtsZ possesses all but one of the key residues proposed in the binding of E. coli FtsZ to berberine (lysine instead of glycine at position 183 of Ec-FtsZ), this may account for the higher concentration of berberine required to inhibit 50% of wBm-Ftsz's GTPase activity.
Figure 4. Berberine sulfate inhibition of the GTPase activity.
Enzyme activity of wBm-FtsZ (•) and Ec-FtsZ (□) was determined in the presence of 0, 25, 50, 100, 200, 400, 600, 800, and 1000 µM berberine sulfate. The data obtained from triplicate samples are expressed as a mean ± standard deviation.
The effect of berberine on the motility and microfilariae production of B. malayi in vitro
Since filarial Wolbachia remain unculturable, we were unable to evaluate the direct effect of berberine on the endosymbiont. Therefore, we examined the indirect effect of the drug on adult female worm. As Figure 5A shows, berberine (10–40 µM) had adverse effects on the motility of adult female B. malayi worms, as well as microfilariae production (Figure 5B) when compared to untreated controls. Two days after treatment with berberine (40 µM), female worms showed almost no movement and the production of microfilaria had virtually ceased. Berberine at 20 µM was comparable to 10 µM of doxycycline in terms of effect on female worm motility. Reduction in adult female motility coincided with a decrease in microfilariae production. Similarly, motility of the freshly released microfilaria was decreased when berberine was present, with some effect observed at the lowest concentration (5 µM) tested (Figure 5C). On the other hand, male worms were more resistant to the effects of the drug with limited reduction in motility observed following treatment with berberine (5–40 µM) for 6 days (Figure 5D). However, treatment with 100 µM berberine for 24 h did completely paralyze male worms (data not shown). Doxycycline (10 µM) had a comparable affect on the motility of male and female worms.
Figure 5. Effect of berberine sulfate on B. malayi parasites in culture.
Motility of adult female (A) and male (D) worms, and microfilariae (C) was examined following 6 days exposure to varying amounts (5–40 µM) of berberine sulfate. 10 µM doxycycline was included as a control. Motility was scored as described [38] and expressed as % of motility relative to motility scored on day 0 of the experiment. Micofilariae production (B) was determined at each time point by counting the number of microfilaria present in 1 mL spent culture media. The data obtained from triplicate samples are expressed as a mean ± standard deviation.
The effect of berberine on E. coli growth, morphology and viability
To demonstrate that berberine's in vitro GTPase inhibitory activity and anti-parasitic activity correlates with its known antibacterial activity, studies were performed on E. coli strain ER1613. Berberine is known to act as a substrate for the multi-drug resistance efflux pumps and ER1613 contains a mutation in the acrA gene, which inactivates the multidrug efflux pump [45]. Overnight incubation of ER1613 with 0–100 µM berberine showed a dose-dependent effect with complete inhibition of bacterial growth observed at 60 µM (Figure 6A). Similarly, no growth was evident when experiments were initiated with greater bacterial densities and the cells were treated with 50 µM berberine for up to 5 h (Figure 6B). Treatment with berberine resulted in the filamentous phenotype (Figure 5C) typically observed in ftsZ mutant strains [46], indicating that berberine was inhibiting cell division. Moreover, the presence of elongated bacteria also correlated with decreased growth and viability. Viability was also evaluated by ability to form colonies on an agar plate. Berberine sulfate-treated (24 hours) cells produced substantially fewer colonies (Figure 6D), compared to untreated controls. Untreated bacteria had approximately 4×105 - fold growth in 24 h, whereas bacteria treated with 40 µM berberine had 4×102 - fold growth. At concentrations of 80 µM and higher, the treated bacteria failed to produce viable colonies (Figure 6D), demonstrating that without active replication E. coli die.
Figure 6. Berberine sulfate inhibition of E. coli growth.
Panel A, overnight growth of E. coli was determined in the presence of various concentrations of berberine sulfate. Percentage of growth is indicated as 100×(OD600 nm with berberine/OD600 nm without berberine). The data obtained from triplicate samples are expressed as a mean ± standard deviation. Panel B, log-phase (5 h) growth (OD600 nm) of E. coli was determined in the presence of various concentrations (10–70 µM) of berberine sulphate. Panel C, DIC micrographs of E. coli untreated (0 µM) or treated with 40 µM or 80 µM berberine sulfate. Panel D, effect of berberine sulfate on E. coli viability. Viability of berberine sulfate-treated (24 hours) cells was evaluated by plating serial dilutions (10−2–10−7) of bacteria (Output shown in duplicate) on a petri dish and incubation overnight at 30 °C. The number of bacteria present in the inoculum used in the experiment (Input) is also shown.
Identification of new inhibitors of wBm-FtsZ GTPase activity
To initiate a campaign to identify molecularly unique inhibitors of wBm-FtsZ GTPase activity, a library of small molecules based on naphthalene, quinoline and biphenyl core scaffolds were examined [39]–[40] (Figure 7A). The library was constructed using Ugi multicomponent reaction chemistry, and each compound consists of a flat aromatic scaffold for enhanced π-stacking interactions decorated with varying diversity elements (R1–R4 in Figure 7A). Importantly, these scaffold motifs are also found in berberine (Figure 7B) and known FtsZ inhibitors [17], [29]–[33]. The ∼500-member library was screened using the wBm-FtsZ GTPase assay, and 13 compounds with greater than 30% inhibition at 100 µM were identified. From these screening efforts, compounds AV-C6 and N938 (Figure 7C) emerged as leading hits, and each showed dose-dependent inhibition of wBm-FtsZ (Figure 8A). AV-C6 and N938 were also examined for inhibition of the E. coli FtsZ enzyme (Figure 8A). As shown in Figure 8A, both compounds inhibited Ec-FtsZ activity although each was slightly less potent compared to the inhibitory activity against wBm-FtsZ.
Figure 7. Structures of FtsZ inhibitors and scaffolds.
General scaffolds for small molecule library compounds (A). Structure of berberine (B). FtsZ inhibitors identified from the initial high-throughput screen (C). FtsZ inhibitors identified from SAR studies (D).
Figure 8. Inhibition of GTPase activity by small molecules.
wBm-FtsZ (▪ and •) and Ec-FtsZ (□ and ○) were compared. Panel A, compounds were tested at the concentration of 30, 40, 50, 60, 70, 80, 90, and 100 µM and the experiment were performed in duplicate, the mean value was plotted. Panel B, compounds were tested at the concentration of 10, 20, 40, 60, 80, and 100 µM and the experiments were performed in triplicate, the mean ± standard deviation was plotted.
Structure-activity relationship (SAR) studies were then performed on N938 as this compound showed the most potential in dose response experiments. In addition to identifying compounds with enhanced potency, we were also interested in exploring the possibility of tuning down any inhibitory activity against Ec-FtsZ in order to obtain a more specific Wolbachia FtsZ inhibitor. A series of analogues were synthesized with varying aromatic side chains (R3 in Figure 7A). As shown in Figure 8B, both goals were met: N982 with an ortho-chloro substituent (Figure 7D) showed enhanced potency in the wBm-FtsZ assay and N983 with a para-cyano substituent (Figure 7D) showed some specificity for wBm-FtsZ over that from E. coli. Future SAR studies should enable the discovery of compounds with both enhanced inhibitory properties and specificity. Finally, as the solubility of these compounds is poor, 100% inhibition of FtsZ with this scaffold was not possible and true IC50 values could not be obtained. Scaffold modification and/or hopping strategies will be investigated in the future to afford enhanced solubility.
The use of antibiotics targeting the Wolbachia endosymbionts of filarial parasites has been validated as an approach for controlling filarial infection in animals and humans. As a result, there is considerable interest in identifying new compounds that specifically target the obligate bacterial endosymbiont. In the present study, we investigated the cell division pathway in wBm to identify new drug targets that may be exploited for the development of new antifilarial therapies. Filamenting temperature sensitive (fts) genes produce many of the proteins essential for cell division in E. coli [17]. In wBm, we identified the majority of core genes that are indispensable to cytokinesis including ftsA, ftsI, ftsK, ftsQ, ftsW and ftsZ.
Interestingly, ftsB, ftsL, ftsN and ZipA were not found in wBm. ZipA is a bitopic membrane protein with a large cytoplasmic domain that binds and bundles FtsZ protofilaments in vitro and helps to stabilize the Z ring in vivo. FtsN is a core component of the divisome that accumulates at the septal ring at the initiation of the constriction process. The C-terminal SPOR domain specifically recognizes a transient form of septal murein, which helps trigger and sustain the constriction process. However, in E. coli, it has been found that alterations in FtsA can compensate for the absence of ZipA, FtsK [47] and FtsN [48] and a gain-of-function FtsA variant, FtsA*(R286W), efficiently stimulates cell division in the complete absence of ZipA [47]. Thus, Wolbachia FtsA may function like the mutant FtsA, as an alanine residue is present in the same position.
ftsB, ftsL, ftsN and ZipA are also absent in some important bacterial pathogens including certain Gram-negative (Neisseria spp., Bordetella pertussis, Helicobacter pylori, Chlamydia spp.) and Gram-positive (Mycobacterium tuberculosis) bacteria and cell wall-lacking (Mycoplasma pneumoniae) organisms [17]. It is likely that this reflects the reduced genome size present in these intracellular bacteria.
FtsZ is the most highly conserved essential bacterial cell division protein and is present in all bacteria except Chlamydia spp [17]. We determined that wBm-FtsZ shares substantial similarity (43% identity) to the highly characterized E. coli FtsZ protein and is highly similar (∼90% identity) to insect Wolbachia FtsZ proteins. While the majority of wBm genes are expressed in a stage-specific manner [49], wBm-ftsZ was found to be expressed in both male and female worms as well as in all larval stages examined. It was not surprising to find wBm-ftsZ expressed throughout the entire lifecycle of the parasite since the bacterial Z-ring is known to exist in a state of dynamic equilibrium in order to fulfill its many roles in the cell. Using fluorescence recovery after photo bleaching (FRAP), the E. coli Z-ring was found to continually remodel itself with a halftime of 30 seconds with only 30% of cellular FtsZ present in the ring with continuous and rapid exchange of subunits within a cytoplasmic pool [17]. E. coli ftsZ transcription analysis has revealed that the rate of ftsZ expression is constant with a sudden doubling at a specific cell age, suggesting that ftsZ expression is regulated [50]. Similarly, we observed up-regulation of wBm-ftsZ gene expression in fourth-stage larvae and adult female worms with microfilariae likely contributing to the increased expression in the latter case. While the lowest levels of gene expression were evident in adult males, FtsZ protein was easily detected in proteomic analyses of male worms [49]. In general, the gene expression pattern of ftsZ correlated with bacterial multiplication. The increased bacterial multiplication in the worm during early infection of the mammalian host and embryogenesis is in agreement with an earlier study [4]. These data are consistent with the third- and fourth-stage larval stages, and embryogenesis being particularly sensitive to the effects of antibiotic treatment [4], [51]. This result indicates that ftsZ gene expression could be used as a marker to monitor Wolbachia multiplication in the filarial parasite much like the ftsZ gene in the intracellular bacterium Candidatus Glomeribacter gigasporarum that resides in the mycorrhizal fungus Gigaspora margarita [43].
Molecular studies have established the importance of conserved amino acids in the FtsZ protein that when changed results in ftsZ mutants blocked at different stages of cell division [42], [46], [52]–[55]. wBm-FtsZ possesses the key residues and conserved GTP-binding pocket required for GTPase activity. Our functional analysis revealed that the GTPase activities of recombinant wBm-FtsZ and Ec-FtsZ are similar, and both proteins are sensitive to the plant alkaloid berberine. Most of the residues in Ec-FtsZ that are thought to bind berberine and inhibit FtsZ GTPase activity are also present in wBm-FtsZ. An earlier detailed study in E. coli determined that the target of this commonly used compound is FtsZ [33]. Plants containing berberine have been used in traditional Chinese and Native American medicine to treat many infectious diseases and the sulfate, hydrochloride and chloride forms are used in Western pharmaceutical medicine as antibacterial agents [56]. It is active against a number of Gram-positive and Gram-negative pathogenic bacteria, including drug resistant Mycobacterium tuberculosis [57] and Staphylococcus aureus [58].
Our experiments in E. coli demonstrate that berberine has both bacteriostatic and bacteriocidal effects. Since filarial Wolbachia remain unculturable, we were unable to evaluate the direct effect of berberine on the endosymbiont. However, following berberine treatment, we did observe reductions in adult female worm and microfilariae motility and microfilariae production. On the other hand, we did not see any effect on male worms, which had the lowest level of wBm-ftsZ gene expression. We examined berberine- and doxycycline-treated worms for Wolbachia load by qPCR analysis and did not observe a significant difference between control and treated parasites. A similar result was also found in a study evaluating the effects of globomycin and doxycycline on filarial Wolbachia, and the authors [59] suggested several possibilities which can also apply to our study, namely: the Wolbachia qPCR assay may not have sufficient sensitivity to detect effects on Wolbachia load over this time frame in nematodes, inhibition of FtsZ is sufficient to affect nematode motility and viability independent of or prior to any effect on Wolbachia load, and/or a direct effect of berberine on nematode motility and viability and alternative mechanisms of action. Nonetheless, our results suggest that FtsZ inhibitors that operate via inhibition of enzyme activity including natural products [28], [30]–[33], [53] and synthetic molecules [29], [60] may have also activity against wBm-FtsZ.
To complement the berberine studies, a library of naphthalene-, quinoline- and biphenyl-based compounds constructed using Ugi multicomponent reaction chemistry was examined for the discovery of new and ultimately highly specific antagonists of either E. coli or Wolbachia FtsZ. Of interest, compounds based on similar scaffolds have already been demonstrated as potent FtsZ inhibitors [17], [29]–[33]. From our screening efforts, the (6-{butylcarbamoyl-[(aryl)-(butylcarbonyl)-amino]-methyl})-naphthen-2-ol scaffold (Figure 7A, C) emerged as an antagonist of both E. coli and Wolbachia FtsZ. Interestingly, from basic SAR studies it appears that modification of the aryl substituent on the scaffold may afford selectivity for Wolbachia FtsZ, a key element of our initial goal. Additional compounds are currently being prepared to examine this possibility. Although not discussed here, compounds based on our lead scaffold had no effect on growth or viability in E. coli. Based on these findings and their potency in the in vitro assays, it is plausible that penetrability or metabolism issues are to blame for their attenuated activity. Finally, the solubility of these compounds is also poor precluding measurement of true IC50 values. Further iterations of chemical synthesis will be necessary to address these potential liabilities.
While we have focused on assaying the GTPase activity of wBm-FtsZ using a medium- to high-throughput coupled enzyme assay for the discovery of inhibitors that target cell division in Wolbachia, it is also possible to screen for compounds that would target wBm-FtsZ via other mechanisms of action. FtsZ is considered a distant functional relative of the mammalian cytoskeletal protein β-tubulin [61]–[63]. Microtubule formation is a major target in cancer chemotherapy and the anticancer drug Taxol binds to β-tubulin and blocks cell division by interfering with microtubule formation. Interestingly, the FtsZ inhibitor PC190723 [60] operates by a similar mechanism and more recently, novel inhibitors of B. subtilis cell division have been identified in an in vitro FtsZ protofilaments polymerization assay [64]. Importantly, significant differences exist in the active sites in tubulin and FtsZ polymers, and several small molecule inhibitors of FtsZ have been identified [65] that do not inhibit tubulin [66]–[67]. Tubulin is also the target of the broadly anti-parasitic benzimidazole drugs [68]–[69], which have been used extensively to control soil-transmitted nematodes [70]–[71].
FtsZ is also responsible for recruiting and coordinating more than a dozen other cell division proteins at the midcell site of the closing septum [18]–[19], [21], [72]. Many of these interactions are essential and it has been suggested that they might also be useful targets, particularly in light of developments in the discovery of small molecule inhibitors of protein-protein interactions [17], [73]–[74]. Therefore, it might be feasible to screen for inhibitors of the interactions between wBm-FtsZ and its various binding partners that modulate its polymerization. Another Wolbachia cell division protein worth considering for drug discovery is FtsA, as this protein also possesses enzymatic activity and contains an ATP-binding site that might be targeted with drug-like molecules. Moreover, this protein is essential in E. coli [75] and Streptococcus pneumoniae [76].
In summary, we have investigated the cell division pathway in wBm and determined that it possesses a FtsZ protein with GTPase activity. We demonstrated that the activity is inhibited by berberine and identified small molecule inhibitors in a high-throughput screen. Furthermore, berberine was found to have adverse affects on B. malayi adult worm and microfilariae motility, and reproduction. Our results support the discovery of selective inhibitors of Wolbachia FtsZ as a new therapeutic approach for filariasis.
We gratefully acknowledge encouragement and support from New England Biolabs and encouragement from Dr. Donald Comb. We thank Brendan Galvin, William Jack and Catherine Poole for critical reading of the manuscript. Total RNA was obtained through the Filariasis Research Resource Center, Division of Microbiology and Infectious Diseases, NIAID, NIH prepared by Dr. Steven Williams' laboratory.
Conceived and designed the experiments: ZL ALG CG KDJ CKC. Performed the experiments: ZL ALG CG. Analyzed the data: ZL ALG CG KDJ CKC. Contributed reagents/materials/analysis tools: ZL ALG CG KDJ CKC. Wrote the paper: ZL ALG KDJ CKC.
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Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes
Felix Schmidt,
Affiliations Neurologische Klinik, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Germany, Zentrum für Neuropathologie und Prionforschung, Ludwig-Maximilians-Universität München, München, Germany
Johannes Levin,
Affiliation Neurologische Klinik, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Germany
Frits Kamp,
Affiliations Neurologische Klinik, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Germany, Deutsches Zentrum für Neurodegenerative Erkrankungen und Adolf-Butenandt-Institut, Ludwig-Maximilians-Universität München, München, Germany
Hans Kretzschmar,
Affiliation Zentrum für Neuropathologie und Prionforschung, Ludwig-Maximilians-Universität München, München, Germany
Armin Giese ,
* E-mail: Armin.Giese@med.uni-muenchen.de
Kai Bötzel
Armin Giese,
Felix Schmidt Johannes Levin ... Kai Bötzel
Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein. Recent findings indicate that pathological oligomers rather than fibrillar aggregates may represent the main toxic protein species. It has been shown that α-synuclein oligomers can increase the conductance of lipid bilayers and, in cell-culture, lead to calcium dyshomeostasis and cell death. In this study, employing a setup for single-channel electrophysiology, we found that addition of iron-induced α-synuclein oligomers resulted in quantized and stepwise increases in bilayer conductance indicating insertion of distinct transmembrane pores. These pores switched between open and closed states depending on clamped voltage revealing a single-pore conductance comparable to that of bacterial porins. Pore conductance was dependent on transmembrane potential and the available cation. The pores stably inserted into the bilayer and could not be removed by buffer exchange. Pore formation could be inhibited by co-incubation with the aggregation inhibitor baicalein. Our findings indicate that iron-induced α-synuclein oligomers can form a uniform and distinct pore species with characteristic electrophysiological properties. Pore formation could be a critical event in the pathogenesis of synucleinopathies and provide a novel structural target for disease-modifying therapy.
Citation: Schmidt F, Levin J, Kamp F, Kretzschmar H, Giese A, Bötzel K (2012) Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes. PLoS ONE 7(8): e42545. https://doi.org/10.1371/journal.pone.0042545
Editor: Joe Z. Tsien, Georgia Health Sciences University, United States of America
Received: July 3, 2012; Accepted: July 10, 2012; Published: August 3, 2012
Copyright: © Schmidt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by the Lüneburg fund for Parkinson's disease research and by the DFG (Grant SFB596-B13 to AG and HK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Synucleinopathies, such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB) and Parkinson's disease (PD) are characterized by deposits of aggregated α-synuclein (α-syn) in the brain [1], [2]. Mutations and amplifications of the α-syn gene in familial PD as well as GWAS studies in sporadic PD indicate that α-syn plays a key role in disease pathogenesis [3]. Although the underlying mechanism of cell death remains unclear, accumulating evidence indicates that disease specific α-syn aggregate formation is a critical event. Pathological oligomers that are formed on pathway to fibrillar aggregates seem to be the most important toxic species [4]–[6]. Notably, overexpression of human α-syn is sufficient to cause apoptosis and damage of cell organelles, without detectable fibril formation [7], [8].
In PD patients, an increase of iron levels has been found in brain regions affected by neurodegeneration [9]. Fe3+ seems to play a pivotal role in α-syn aggregation since it is able to trigger the formation of distinct oligomers of α-syn in vitro [10]. Correspondingly, in cell culture, Fe3+ was able to induce oligomerization of α-syn leading to cytotoxicity [11]. Moreover, it was shown that iron-induced α-syn oligomers enhance pre- and postsynaptic transmission, alter intracellular calcium homeostasis and lead to cell death in primary cultures of cortical neurons [12]. Interestingly, the formation of this oligomer species is favored by oxidative stress [13]
One possible mechanism of oligomer toxicity is the formation of lipid bilayer permeabilizing pores [14] resulting in cytotoxicity [10]–[12]. Indeed, oligomers dissociated from preformed α-syn fibrils were able to increase the conductance of lipid bilayers [15]. Formation of pores by oligomeric intermediates may be a fundamental mechanism of cell death in a large range of neurodegenerative diseases. Morphologically, the formation of annular pore-like structures was shown for several proteins deposited in various neurodegenerative diseases including α-syn, Aβ, prion protein and polyglutamine-containing proteins. Moreover, in some instances an increase in the permeability of membranes could be shown [14].
An important question remaining to be addressed is whether the binding of pathological protein aggregates to membranes results in an unspecific “diffuse” membrane damage, like membrane thinning or disruption [16], [17], or in the formation of distinct pores. The aim of this study was to characterize the potential pores formed by α-syn oligomers at the single-channel level to resolve this issue. The finding of a distinct and surprisingly uniform pore species might provide a promising novel structural target for therapeutic intervention in neurodegenerative diseases.
Expression and purification of recombinant human α-syn
Expression and purification was performed as described previously [10], [18], using pET-5a/α-synuclein (136TAT) plasmid (wt-plasmid by Philipp Kahle, LMU Munich; the 136-TAC/TAT-Mutation was performed by Matthias Habeck, ZNP Munich). The purified protein was adjusted to 1 mg/ml by dilution in 50 mM Tris-HCl, pH = 7.0 and stored at −80°C after freezing in liquid nitrogen.
Preparation of α-syn oligomers
Recombinant human α-syn was incubated in 50 mM Tris-HCl, pH = 7.0 with 1% DMSO (Sigma-Aldrich, Taufkirchen, Germany) and 20 µM FeCl3 (Merck, Darmstadt, Germany) without agitation at RT in a total volume of 200 µl using various concentrations and incubation times, with or without inhibitors of protein aggregation.
Inhibition of pore formation
Baicalein was previously shown to strongly inhibit aggregation of α-syn in vitro and α-syn toxicity in cell culture [10], [19]. Therefore we tested its influence on pore formation by co-incubation of α-syn with 50 µM baicalein in presence of 1% DMSO (Sigma) and 20 µM FeCl3 (Merck).
Influence of α-syn on electrophysiological properties of planar lipid bilayers
Planar lipid bilayers were produced in the Ionovation Compact (Ionovation, Osnabrück, Germany) by the painting technique [20]. Two bath chambers separated by a Teflon-septum were filled with 250 mM KCl, 10 mM MOPS, pH = 7.2 (Merck). In the cis-chamber, 2 µl of a 100 mg/ml-solution of purified azolectin in n-Decane (Ionovation) was applied to a pinhole of 120 µm in diameter. After 30 min incubation at RT, lipid was thinned out by repetitive lowering and re-raising of the buffer-level until a bilayer was formed. Bilayer formation was monitored optically and by capacitance- and conductance-measurements. The resulting bilayers had a typical capacitance of 60–80pF and a resistance of >100GΩ. The monitoring of the bilayer was performed using Ag/AgCl-electrodes (Ionovation), an EPC 10-amplifier and Patchmaster-software (HEKA, Lambrecht/Pfalz, Germany). The electrode in the cis-chamber was directly connected to the amplifier, so all potentials are referred to this compartment. The noise was ∼0.4pA (r.m.s.) at 3 kHz bandwidth.
After bilayer formation, we waited for 10 min to ensure application of the protein to a stable bilayer-system. Then, α-syn aggregation samples (total assay volume: 200 µl) were added in aliquots of 20 µl close to the membrane in the trans-chamber. The electrophysiological properties were monitored using +/−20 mV-squarewave-voltage pulses. Pore formation resulted in an increase in the current flow over the membrane compared to an intact bilayer (Fig. 1A). Threshold for pore detection was set to a conductance of 70pS. If no increase in bilayer conductance beyond the threshold was detected for 5 min, the next aliquot of the sample was added. Pore detection rate was defined as the probability of pore detection per α-syn aggregation sample. In the event of an increase in bilayer conductance, a standardized recording-protocol was employed, consisting of a voltage-ramp reaching from −100 to +100 mV over 10 sec and different squarewave-voltage pulses (10 sec each at −60/−50/−40/−30/−20/−10/0/+10/+20/+30/+40/+50/+60 mV, 5× −40 mV, 5× +40 mV, −60/−70/−80/−90/−100/−110/−120 mV, 5× −80 mV, +60/+70/+80/+90/+100/+110/+120 mV, 5× +80 mV)) to characterize the potential α-syn pore electrophysiologically. Conductance was calculated from the voltage-current-recordings and corrected for the current noise at 0 mV using a Matlab-based program (The MathWorks, Natick, MA, USA).
Figure 1. Detection of α-syn pores.
A) Pore formation results in increased current-flows over the membrane (black trace) compared to intact bilayers (grey trace) when a voltage ramp is applied. B) Pore detection rate for oligomers obtained with 2.1 µM α-syn with 1% DMSO and 20 µM Fe3+ at RT. 4 and 24 h of incubation did not lead to any pore detections (N = 8, each). In 33% of all 48 h-samples (N = 9) pore formations could be detected, increasing to a maximum at 72 h (N = 10). Further incubation results in a decrease of pore detection (N = 10). Non-incubated α-syn monomers did not lead to pore detections (N = 4), as well as DMSO and Fe3+ (“buffer”) after all tested incubation times (N = 4, each). α-hemolysin was used as a positive control (α-HL; N = 4). C) In a further set of experiments, the effects of different α-syn concentrations and the effect of the aggregation inhibitor baicalein were investigated after incubation of α-syn for 72 h with DMSO and Fe3+. Shown is the probability of pore detection following sequential application of aliquots of the respective samples to the bilayer. α-syn was used at 7.0 µM (N = 69), 2.1 µM (N = 35) and 0.7 µM (N = 8) with up to 9 aliquots applied per sample. With decreasing α-syn concentration, cumulative pore detection rate decreases significantly (p<0.001). Co-incubation of 2.1 µM of α-syn with 50 µM of baicalein (N = 8) significantly decreases pore detection compared to 2.1 µM control condition (p<0.005). D) When different voltages were clamped to membranes with inserted pores, step-like changes in conductivity were consistently observed during the duration of the voltage-pulse.
Influence of different cations on pore-conductance
Following pore characterization in presence of KCl (see above), in some experiments the chamber-buffer was perfused with 30 ml of 250 mM NaCl, 10 mM MOPS, pH = 7.2 (Merck) with 7.2 ml/min in both chambers until the buffer was completely exchanged to NaCl buffer. Then the same squarewave-voltage pulse protocol as in presence of KCl was used.
Statistical analysis was carried out using SigmaStat 3.5 software (Systat Software, Erkrath, Germany). Threshold for significance was set to p<0.05.
Time-course and concentration-dependency of pore formation and detection
In this study, changes in the permeability of a planar lipid membrane upon addition of preformed oligomers of α-syn were monitored. First we optimized aggregation conditions towards maximum pore detection rate. For incubation times of 4 h and 24 h no pore formation was observed. However, pore detection rate increased to a maximum after 72 h of incubation. Further incubation (96 h) resulted in a decrease of the pore detection rate (Fig. 1B). Non-incubated monomeric α-syn did not lead to pore detections, as well as DMSO and Fe3+ in the absence of α-syn at all tested incubation times. α-hemolysin was used as a positive control for the formation of distinct oligomer pores in lipid-bilayers. Additionally, pore detection was dependent of protein concentration. 7 µM of α-syn incubated resulted in a cumulative pore detection rate of >90% over all applied aliquots of the aggregation sample, decreasing for concentrations of 2.1 and 0.7 µM (Fig. 1C).
Inhibiton of pore formation
As pore formation by α-syn seemed to be in the dynamic range for a protein concentration of 2.1 µM, we tested the influence of baicalein on pore formation at this concentration. Co-incubation of α-syn with baicalein resulted in a significantly decreased pore detection compared to control conditions (Fig. 1C).
Conductance steps observed for α-syn pores
Having established optimal pre-incubation conditions to generate pore forming α-syn oligomers, we performed all further experiments using 7 µM protein concentration and 72 h of incubation at RT. By applying voltage pulses to membranes with an inserted pore, and analyzing current flows with a standardized protocol (see Materials and Methods) we consistently observed distinct step-like changes of conductivity during the duration of the voltage pulse (Fig. 1D). For 74 pore formation events, by plotting the number of all steps per recorded trace against the clamped voltage, an asymmetric behavior of the pore conductance G became apparent (Fig. 2A). First higher voltages resulted in more steps per trace (up to approx. 1step/sec). Second for positive clamped voltages considerably more steps were observed than for negative voltages. Third there was a slight shift to more G-decreasing events at high positive voltages.
Figure 2. Characterization of α-syn pores.
A) Depending on clamped voltage, the number of steps increasing or decreasing pore conductance (“G-up” and “G-down” refer to the number of steps per recorded trace of 10s) differs (N = 18804 steps in 74 pore formations with 42 traces each). At higher voltages, more steps can be detected per trace. For positive voltages, more steps are observed than for negative voltages. B) A histogram summarizing the distribution of all measured conductance-steps (N = 18804) reveals a symmetrical distribution of steps with a well-defined peak for the main step-size of +/−50 to +/−100pS depending on the clamped voltage (as the number of steps was different for the different voltages, histograms were normalized by setting maxima to 100%). C) Maxima of step size distribution are plotted against clamped voltage. For positive voltages, step size is higher than for negative clamped voltages and increases linear with clamped voltage with a significant positive correlation (p≤0.0001). D–E) All pores characterized both in KCl- and NaCl-buffer show a transmembrane current flow after buffer exchange (N = 9). After exchange to NaCl-buffer, conductance steps are still observed with a similar rate and distribution as in KCl-buffer (see also Fig. 1A). F) For positive clamped voltages, the conductance increases linear with the clamped voltage in KCl-buffer (see also Fig. 1C, p≤0.0001). In contrast, lower conductance levels for high positive voltages are observed in NaCl-buffer that decrease linear with clamped voltage (p≤0.0005).
As conductance-steps were voltage-dependent, histograms of the distribution of step sizes were calculated separately for different voltages. The distribution of step-sizes stratified for voltage from 74 independent experiments available for detailed analysis are summarized in Fig. 2B which shows two distinct main peaks distributed symmetrically around 0pS. A voltage-dependency of pore-conductance is evident, when the maxima of the distribution of step sizes are plotted against the clamped voltage (Fig. 2C). For positive voltages the step-size is higher and shows a significant positive correlation with the clamped voltage.
Cation-dependency of pore-conductance
We found that conductance was still increased after complete exchange of the chamber-buffer from KCl to NaCl in all pore detections analyzed under both conditions. Moreover, conductance steps still arise in a similar voltage-dependent distribution (Fig. 2D, E). However, K+→Na+ exchange led to a change in pore-conductance. Plotting the maximum of the distribution of conductance steps (see also Fig. 2B, C) in presence of NaCl or KCl, conductance was increased at higher positive voltages for KCl, but decreased for NaCl (Fig. 2F).
Detailed analysis of conductance steps at +80 Mv
The highest number of conductance steps (N = 4435) was recorded at +80 mV due to voltage-dependency and a higher number of traces recorded at this voltage. Thus, detailed quantitative analysis of the distribution of conductance steps and conductance levels was performed for this voltage (Fig. 3A, B). The histogram of conductance levels shows distinct peaks that differ from each other by ∼100pS, indicating quantization of conductivity with a smallest step of ∼100pS. Correspondingly, the distribution of step sizes shows a well-defined maximum at ∼100pS with very small additional maxima at multiples of this quantum unit. These quantized steps and conductance levels can be explained by changes in the number of open pores with similar conductance inserted in the bilayer. To further scrutinize this model, we used the data obtained in individual experiments and analyzed the correlation between number and magnitude of conductance levels and step sizes. Figure 3C–K shows examples from 3 representative individual experiments differing in regard to the number of distinct conductance levels observed. In these experiments, either two (Fig. 3C–E), three (Fig. 3F–H) or four (Fig. 3I–K) peaks in the distribution of conductance levels were seen. However, independent of the number of maxima of conductance levels, these maxima always differed by a step size of ∼100pS. This fits well with a model based on changes in the number of open pores being present, whereas the inter-experimental variation in the number of conductance levels observed would be difficult to accommodate in a model based on different conductance level of one individual pore. Thus, these results could best be explained by the presence of either 0–1, 0–2 or 0–3 open pores in the experiments shown in Figure 3C–E, F–H and I–K, respectively. Notably, the conductance level for no open pore inserted is slightly above zero and highest in the experiment with up to three open pores being detected.
Figure 3. Distribution of conductance levels and conductance steps measured at +80 mV.
A) Histogram analysis of all conductance levels measured at +80 mV for all experiments with pore detection (N = 4435 steps in 74 pore formations) shows a quantized distribution of conductance levels with a quantum unit of ∼100pS. The red line represents the running-mean over 8 values, arrows indicate maxima. B) The distribution of corresponding step sizes found in these measurements indicates a common quantized step size of ∼100pS and multiples of this. Panels C–K show the data of individual experiments with putative insertion of either one (C–E), two (F–H) or three pores (I–K). The leftmost panel (C, F, I) shows that conductance levels and corresponding consecutive steps in conductance are not independent from each other, but show a clear clustering of data points. The histograms of conductance levels in the middle panel (D, G, J) show different numbers of distinct peaks depending on the number of inserted pores but not differing in quantization with a common unit of ∼100pS. The histograms of observed conductance steps (E, H, K) show a common main step size of ∼100pS and, rarely, multiples of this unit in experiments with more than one pore inserted into the membrane.
Pore formation has been proposed as a key mechanism of oligomer toxicity in neurodegenerative diseases which are characterized by pathological protein aggregation. At the morphological level, formation of quite uniform annular oligomers has been described for several amyloidogenic proteins [14]. However, a detailed electrophysiological characterization at the single-channel level has been missing.
We previously provided a detailed morphological and structural characterization of iron-induced α-syn oligomers based on single-particle spectroscopy and atomic force microscopy [10]. It was shown that these oligomers are able to interact with lipid membranes, to permeabilize lipid vesicles and to increase the conductance of lipid bilayers [10], [21], [22]. Notably, membrane permeabilization could be blocked with the oligomer-specific antibody A11 [4], [10]. Moreover, we showed that iron-induced oligomers modulate electrophysiological properties of neuronal cells and are toxic in cell culture [11], [12]. Beyond this, baicalein, an inhibitor of α-syn aggregation [19] that we previously showed to inhibit the formation of iron-induced membrane-binding α-syn oligomers and toxicity in cell culture [10], [21], strongly inhibited pore formation in our electrophysiological study. In addition, we demonstrated that anle138b, a compound that specifically inhibits α-syn oligomer formation both in vitro and in vivo also inhibits α-syn induced membrane permeabilization in our lipid bilayer system and rescues the motor phenotype in animal models of PD [23]. Thus, we used this type of structurally and functionally well-characterized oligomers for detailed analysis of potential pore formation by single-channel electrophysiology.
In principle, α-syn oligomers could affect membrane conductance by different molecular mechanisms (Fig. 4). It has been proposed that oligomers could increase lipid bilayer conductance by a “diffuse” damage to the bilayer (model A, Fig. 4A). However, we reproducibly observed discrete step-like changes in the transmembrane current traces (Fig. 1) and well-defined peaks in the distribution of conductance levels and step sizes (Fig. 2). These results would be difficult to explain by a model based on unspecific “diffuse” bilayer damage. In contrast, in a model based on distinct transmembrane oligomer pores, distinct conductance levels could easily be accommodated. Steps in conductance could be explained by different processes. First, a rapid conformational switch of individual transmembrane pores could result in multiple different conductance states (model B, Fig. 4B). Second, conductance-steps could be explained by fluctuations in the number of pores. These fluctuations could be either due to spontaneous insertion and de-insertion into the membrane (model C, Fig. 4C) or due to open and closure events of permanently inserted pores (model D, Fig. 4D). Model C can be excluded as conductance steps in both directions are preserved after complete buffer-exchange (Fig. 4D–F), which removes all non-inserted oligomers available in the chamber buffer for potential (re-)insertion into the membrane.
Figure 4. Schematic illustration of different models for increased membrane permeability caused by α-syn oligomers.
In principle, α-syn oligomers could cause increased conductance of lipid membranes by different modes of action. A) A diffuse damage of the bilayer could lead to an unspecific increase in transmembrane current flow. B) Distinct pores could be formed in the bilayer that switch between two or more different conformational states, resulting in corresponding changes in conductivity. C) Different numbers of uniform pores could spontaneously insert and de-insert into the membrane leading to step-like changes in conductivity. D) The number of “open” pores could fluctuate due to open and closure events of permanently inserted pore complexes.
We found that the distribution of conductance-levels that differ from each other by a defined quantized step size (Fig. 3A, B). This suggests insertion of multiple uniform pores (model D) rather than many different conformational states of a single pore (model B). This reasoning is supported further by the detailed analysis of individual experiments. If multiple conductance states were caused by multiple states of one single pore, these states should, in principle, be consistently detectable in all individual experiments. However, we found that experiments differed in regard to the maximum conductance observed, but consistently showed the same quantization and the same step size (Fig. 3C–K), which argues against model B. As described for Fig. 3, our results can best be explained by stable insertion of variable numbers of uniform pores that switch between an open and a closed state in the individual experiments (model D). Opening and closure of pores may occur either independently or - more rarely – at the same time resulting in steps of ∼100pS (in the case of +80 mV clamped voltage) or multiples of this quantum unit. Of note, the baseline conductance of bilayers with all inserted pores being in the closed state (i.e. the leftmost histogram peak in Fig. 3D, G, J) seems to depend on the number of inserted pores. This finding suggests that also “closed” pores may result in a small leak current that slightly increases baseline conductance and provides a further piece of evidence arguing against model C.
Taken together, our results indicate that distinct and uniform pores are formed as a complex of α-syn molecules by a well defined assembly. Beyond this, these pore complexes share key properties with bacterial porins, which provide an example of oligomer pores optimized by evolution to mediate cellular toxicity. Interestingly, bacterial porins also show step-like changes of conductivity [24], [25] that have been interpreted as voltage-dependent open and closure events [25]–[27]. Due to its unidirectional incorporation into lipid bilayers, the conductance of Omp34-channels shows a dependency on the polarity of the clamped voltage [27]. Again, this is in line with our findings for α-syn pores, which further corroborates the concept of a distinct and uniform pore complex. The conductance of pores formed by α-syn oligomers in our study is only slightly less than conductances reported for bacterial pore-forming toxins (α-hemolysin 240pS [28], [29], Omp-porins 450pS [24] in comparable conditions), indicating that the resulting current flow could be sufficient to induce toxic effects. This reasoning is further supported by the finding that compounds that inhibited the formation of iron-induced α-syn oligomers and blocked oligomer-induced transmembrane currents in vitro also reduced toxicity in cell-culture- and in vivo-models of PD [10]–[12], [23].
Taken together, our results indicate that α-syn oligomers can form a distinct and uniform pore complex. Notably, the α-syn pore complex identified by us shares several electrophysiological properties with bacterial porins such as the dependence of pore-conductance on both direction and magnitude of the clamped voltage and the available cation [27], [30], [31]. Because of its distinct and uniform electrophysiological properties, the α-syn pore complex described here might represent a specific particle species that could provide a novel target structure for the development of drugs that inhibit oligomer pore formation or modulate the electrophysiological properties of these pores.
Conceived and designed the experiments: FS JL FK AG KB. Performed the experiments: FS. Analyzed the data: FS AG KB. Contributed reagents/materials/analysis tools: FS FK HK KB. Wrote the paper: FS JL FK AG KB.
1. Goedert M (2001) Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2: 492–501.
2. Ross CA, Poirier MA (2004) Protein aggregation and neurodegenerative disease. Nat Med 10: S10–S17.
3. Martin I, Dawson VL, Dawson TM (2011) Recent Advances in the Genetics of Parkinson's Disease. Annu Rev Genomics Hum Genet 12: 301–325.
4. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, et al. (2003) Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis. Science 300: 486–489.
5. Glabe CG, Kayed R (2006) Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology 66: S74–S78.
6. Irvine GB, El Agnaf OM, Shankar GM, Walsh DM (2008) Protein Aggregation in the Brain: The Molecular Basis for Alzheimer's and Parkinson's Diseases. Mol Med 14: 451–464.
7. Gosavi N, Lee HJ, Lee JS, Patel S, Lee SJ (2002) Golgi Fragmentation Occurs in the Cells with Prefibrillar alpha-Synuclein Aggregates and Precedes the Formation of Fibrillar Inclusion. J Biol Chem 277: 48984–48992.
8. Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, et al. (2010) Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J 29: 3571–3589.
9. Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds GP, et al. (1988) Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J Neural Transm 74: 199–205.
10. Kostka M, Hogen T, Danzer KM, Levin J, Habeck M, et al. (2008) Single Particle Characterization of Iron-induced Pore-forming α-synuclein Oligomers. J Biol Chem 283: 10992–11003.
11. Hillmer A, Putcha P, Levin J, Högen T, Hyman BT, et al. (2010) Converse modulation of toxic α-synuclein oligomers in living cells by N′-benzylidene-benzohydrazide derivates and ferric iron. Biochem Biophys Res Commun 391: 461–466.
12. Hüls S, Högen T, Vasallo N, Danzer K, Hengerer B, et al. (2011) AMPA-receptor mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers. J Neurochem 117: 868–878.
13. Levin J, Högen T, Hillmer A, Bader B, Schmidt F, et al. (2011) Generation of Ferric Iron Links Oxidative Stress to α-Synuclein Oligomer Formation. Journal of Parkinson's Disease 1: 205–216.
14. Lashuel HA, Lansbury PT Jr (2006) Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? Q Rev Biophys 39: 167–201.
15. Kim H-Y, Cho M-K, Riedel D, Fernandez CO, Zweckstetter M (2008) Dissociation of Amyloid Fibrils of a-Synuclein in Supercooled Water. Angew Chem 47: 5046–5048.
16. van Rooijen BD, Claessens MMAE, Subramaniam V (2010) Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism. PLoS ONE 5: e14292.
17. Reynolds NP, Soragni A, Rabe M, Verdes D, Liverani E, et al. (2011) Mechanism of Membrane Interaction and Disruption by α-Synuclein. J Am Chem Soc 133: 19366–19375.
18. Nuscher B, Kamp F, Mehnert T, Odoy S, Haass C, et al. (2004) α-Synuclein Has a High Affinity for Packing Defects in a Bilayer Membrane. J Biol Chem 21: 21966–21975.
19. Zhu M, Rajamani S, Kaylor J, Han S, Zhou F, et al. (2004) The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. J Biol Chem 279: 26846–26857.
20. Mueller P, Rudin DO, Tien HT, Wescott WC (1962) Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System. Nature 194: 979–980.
21. Högen T, Levin J, Schmidt F, Caruana M, Vasallo N, et al. (2012) Two different binding modes of α-Synuclein to lipid vesicles depending on its aggregation state. Biophys J 102.
22. Caruana M, Neuner J, Högen T, Schmidt F, Kamp F, et al. (2012) Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro. Biochim Biophys Acta
23. Levin J, Wagner J, Ryazanov S, Leonov A, Shi S, et al. (2011) Causal therapy of Parkinson's disease with anle138b, a novel protein aggregation inhibitor. Mov Disord 26: S21.
24. Benz R, Schmid A, Hancock REW (1985) Ion Selectivity of Gram-Negative Bacterial Porins. J Bacteriol 162: 722–727.
25. Delcour AH (1997) Function and modulation of bacterial porins: insights from electrophysiology. FEMS Microbiol Lett 151: 115–123.
26. Lakey JH, Watts JP, Lea EJA (1985) Characterization of channels induced in planar bilayer membranes by detergent solubilised Eschericha coli porins. Biochim Biophys Acta 817: 208–216.
27. Brunen M, Engelhardt H (1993) Asymmetry of orientation and voltage gating of the Acidovorax delafieldii porin Omp34 in lipid bilayers. Eur J Biochem 212: 129–135.
28. Kraslinikov OV, Sabirov RZ, Ternovsky VI, Merzliak PG, Tashmukhamedov BA (1988) The structure of Staphylococcus aureus alpha-toxin-induced ionic channel. Gen Physiol Biophys 7: 467–473.
29. Hemmler R, Böse G, Wagner R, Peters R (2005) Nanopore Unitary Permeability Measured by Electrochemical and Optical Single Transporter Recording. Biophys J 88: 4000–4007.
30. Benz R, Schmid A, Wagner W, Goebel W (1989) Pore Formation by the Eschericha coli Hemolysin: Evidence for an Association-Dissociation Equilibrium of the Pore-Forming Aggregates. Infect Immun 57: 887–895.
31. Song L, Hobaugh MR, Shustak C, Cheley S, Bayley H, et al. (1996) Structure of Stapphylococcal alpha-Hemolysin, a Hemptameric Transmembrane Pore. Science 274: 1859–1866.
Oligomers
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Lipid bilayer
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Membrane electrophysiology
Is the Subject Area "Membrane electrophysiology" applicable to this article?
Electrophysiological properties
Is the Subject Area "Electrophysiological properties" applicable to this article?
Is the Subject Area "Lipids" applicable to this article?
Is the Subject Area "Membrane potential" applicable to this article?
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Is the Subject Area "Toxicity" applicable to this article?
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Florida Deputy Helps Save Unresponsive Baby’s Life
Posted 4:15 AM, May 11, 2018, by CNN Wire
Deputy Jeremie Nix was on his way home when a woman flagged him down and told him her baby was unresponsive.
Shortly after, the officer was rushing to a Florida hospital with the 3-month-old boy in his arms.
“I’m not waiting on medics … I’m headed to the emergency room with the baby,” he told a dispatcher Wednesday.
Dashcam video released by the Marion County Sheriff’s Office shows the deputy making a U-turn at a red light in Ocala, Florida, before pulling on the side of the road to meet baby Kingston and his mother.
Nix quickly took the baby in his arms and put him on the ground, the video shows.
“I just kind of panicked and started crying and I was just like tell me that he is breathing,” the boy’s mom, Nechole Crowell, told CNN affiliate WESH.
For several minutes, he performed “several life-saving measures on the child” but didn’t see any improvement, the sheriff’s office said in a statement.
With no ambulances or medics around, Nix grabbed the boy, got in his patrol car and drove to the Ocala Regional Medical Center.
“I remember praying, thanking God for putting me in the right place, at the right time for the right reason,” Nix told reporters Thursday. “This was the most emotional day I’ve ever had in my career. It was also the scariest and the most rewarding.”
Kingston was discharged from the hospital Thursday and is expected to make a full recovery, the sheriff’s office said.
“We are tremendously proud of Deputy Nix and we can already see that he and Baby Kingston will have a deep connection that will last a lifetime,” the sheriff’s office said.
Filed in: Nation/World
Topics: Florida, Jeremie Nix, marion county sheriff's office, Nechole Crowell
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Michael Strahan tells Ellen he would kneel during anthem if he was still playing
Posted: 12:18 PM, Sep 11, 2018
By: Tim Griffin
Michael Strahan is one of the most popular American sports commentators, seemingly appearing on countless platforms during football season.
But Strahan had an interesting comment during his appearance Monday on Ellen DeGeneres’ show.
Strahan cited his father’s military career when he said that those protests by former San Francisco 49ers quarterback Colin Kaepernick and other NFL players were not mean to disrespect “anybody in the armed services.” He added he would kneel during the national anthem if he was still playing today.
“I know why [Kaepernick] knelt was not in any disrespect to the military or anybody in the armed services because I have an appreciation for that,” Strahan said. “And when my father can look at me and tell me that he’s not offended and that he understands, then how could I — who didn’t do that service — be offended?”
Strahan also said that he “would’ve been proactive” in getting involved if he was till playing.
“Because I do believe that there needs to be more organization between the players and the ownership.”
Of course, if Strahan had joined those who are kneeling today, he likely wouldn’t have a post-football career like the one he is currently pursuing.
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Murder, robbery charges filed against suspect in August quadruple homicide
Posted 11:05 pm, December 15, 2017, by Kevin S. Held, Michelle Madaras and Kelley Hoskins
Ja’Vonne Dupree, 20
ST. LOUIS COUNTY, Mo. – Homicide detectives in north St. Louis County have a person custody in connection with a quadruple homicide from earlier this summer. On Friday, police announced that a suspect, later identified as Ja’Vonne Dupree, 20, of the 5300 block of Arsenal Street in St. Louis, was arrested in Columbia, MO.
On Saturday, the St. Louis County Prosecuting Attorney’s Office charged Dupree with four counts of Murder in the 1st Degree, four counts of Robbery in the 1st Degree, nine counts of Armed Criminal Action, one count of Burglary in the 1st Degree, one count of Stealing of a Motor Vehicle, and one count of Tampering With Physical Evidence in a Felony Prosecution. Dupree does not have a bond.
The probable cause statement reads: The four victims were found deceased in a residence on Balmoral Drive. All four died from gunshot wounds. Defendant was identified as the person who unlawfully remained at the residence on Balmoral Drive, shot each of the victims, robbed the victims of electronics and clothing, picked up multiple shell casings, and fled the murder scene in the victim’s car with the stolen items.
The murders took place August 24, 2017, in the 10400 block of Balmoral Drive in Glasgow Village. Police were conducting a welfare check after family members had not heard from loved ones and 57-year-old Patricia Steward didn’t show up for work.
Officers arrived at the house where they found four people shot and killed. The victims were Steward, her 10-year-old son adopted son Terrence Dehart, her 20-year-old son Joseph Corley, and Corley’s friend 18-year-old Deandre Kelly.
“I love that family because we’re dealing with this together. They love DeAndre. DeAndre obviously loved them otherwise he would have never been around them. Did I trust the family yes I did trust the family,” says DeAndre Kelley’s mother Angelia Jones.
Police say Dupree was staying at the home when he shot the victims, took their clothes and electronics, then he picked up some of the shell casings before stealing their car and driving off.
“I was never a big fan of the death penalty now I’m pushing for it after this heinous crime,” says Jones.
It appears this isn’t the first time JaVonne Dupree has had a run in with the law. A person with the same name and birth date was arrested for theft in Chesterfield, MO in 2015 and was on probation at the time of these murders.
Reward increased to $20K for information leading to arrest in quadruple homicide
Killer still on the run following quadruple homicide in north St. Louis County
Topics: charges filed, Ja’Vonne Dupree, Quadruple homicide
Wentzville man charged for murder of prominent Edwardsville attorney
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Homicide investigation in south St. Louis County; man found dead on porch
Murder charge filed for Florissant arson suspect
2 suspects charged in Wellston homicide
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January 21, 2020 / Kim Golden Malmgren / Leave a comment
Title: The Winter Companion
Author: Mimi Matthews
Publication Date: 11 February
Available for preorder
Amazon – Apple Books – BN – Kobo
Yet again, Mimi Matthews delivers a deliciously addictive and wonderfully written love story with The Winter Companion. This time, we delve into the lives of Neville Cross and Clara Hartwright. If you’ve been following the Parish Orphans of Devon series, then you’ve already had glimpses of Neville. Of all the boys (now men) who’d grown up together in the orphanage, I was always most curious about Neville, especially considering the injury he’d sustained from his fall from the cliffs. We get more insight into his life and how his BTI has affected him and the choices he’s made along the way.
With the coming Christmas holidays as the backdrop, Matthews sets the stage for a very nice slow-burn love story. We have Neville, painfully shy at times and more at home outdoors than in drawing rooms making small talk, and Clara, a paid companion to Mrs. Bainbridge who longs to learn and know more–but held back because of her gender and a secret from her past. Already from their first meeting, thanks to an elderly pug called Bertie, we know that Neville and Clara are meant to be. The question is how will it come to pass. And their path to love is very satisfying.
There are so many things that I loved about The Winter Companion: the richness of the setting, how Matthews weaves in the cast of characters we recognize from previous books in the series, how even the secondary characters come across as fully realized people and not simply as props… I could go on. But the most important factor for me in loving this book was how Matthews writes about Neville and his brain trauma injury. Gaining insight into how it has affected his life and how he’s tried to deal with it…as well as the initial resentment he felt at being the one left behind…made me as a reader feel such empathy for him and gave me a better understanding of why Neville never strayed far from the abbey.
I also enjoyed that Matthews allows us time to get to know Neville and Clara. They’re complex characters and having the chance to find out how life’s experiences made them who they are gave even more depth to their story.
If you like historical romance, then I think you’ll love the Winter Companion. For me, reading this book was pure pleasure. Highly recommended!
Review: In Black & White by Nia Forrester
August 11, 2019 / Kim Golden Malmgren / Leave a comment
Nia Forrester never fails to create realistic portrayals of love that I always find so beautifully written. She never disappoints. And this is definitely true in her latest, In Black & White.
Set in a leafy suburb of Philadelphia, we’re immediate dropped into what is every parent’s nightmare–the disappearance of a child. In this case, it’s the disappearance of 18-month-old Samara, the daughter of interracial couple Noah and Dana. Samara’s abduction and the subsequent fallout around it mark the beginning of a fascinating story that is in parts mystery and a thoroughly modern story of a love on the rocks.
Forrester is a master at crafting three-dimensional characters. Dana and Noah are no different. From the first chapter when we learn the status of their marriage, we are given a very realistic, sometimes heartbreaking, sometimes frustrating portrayal of a couple who come from different worlds. Noah is the product of privileged, old Pennsylvania money. Dana is his polar opposite–raised in a working-class neighbourhood in Baltimore by her grandmother and her older sister, she has struggled to get used to the life of privilege being Noah’s wife affords, especially since her skin color will always mark her as out of place in the world that Noah comes from. One of the aspects I loved about In Black & White is how Forrester deftly takes us through the couple’s history and its relevance to their separation. These snippets of their shared past help the reader understand who Dana and Noah were when they first met and what attracted them to one another as well as what has driven them apart.
This is not a sugar-coated, fantasy-laden love story, so if that’s what you’re looking for, then this isn’t going to be the book for you. But if you’re in the mood for a very realistic look at a modern love and marriage, racial and socioeconomic differences (and how it can make or break a couple), and how the disappearance of a child can unveil secrets, then you’re going to love In Black & White.
Highly recommended! 5 stars.
REDESIGNING HAPPINESS BY NITA BROOKS
August 1, 2019 / Kim Golden Malmgren / Leave a comment
Real life is a work in progress… #DesignYourLife
It wasn’t easy for Yvonne Cable to get over a heartbreaking relationship and revamp her life. But now the once-broke single mom is Atlanta’s most sought-after interior designer—and one-half of the media’s hottest power couple. She and her celebrity fiancé, Nathan, are a perfect, practical match, on—and off—camera. And with their new home improvement reality show the object of a fierce network bidding war, there’s no limit to how far they can go . . .
But Yvonne is stunned when mogul Richard Barrington III unexpectedly makes an offer for their program. He’s the man she thought left her for a more successful woman. And he’s the father of her son—though he didn’t know it until now. Richard wants to get to know their boy, and Yvonne agrees, though she’s wary. Yet little by little, she’s finding it hard to resist the responsible, caring man Richard has become. But when a scandalous leak puts everything Yvonne’s worked for at risk, she’ll have to look beyond surfaces to come to terms with who she is—and discover what she truly wants.
AMAZON | KENSINGTON | BARNES & NOBLE
Nita Brooks is giving away a signed copy of Redesigning Happiness & a $10 Amazon gift card to a lucky winner!
ABOUT NITA BROOKS
A reading addict, self-professed connoisseur of home improvement shows, and a collector of teapots, Nita Brooks resides in South Carolina with her family. You can connect with her on Facebook and Twitter at @AuthorNitaB.
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New Release: Torn by Brooklyn Knight
April 1, 2019 April 1, 2019 / Kim Golden Malmgren / Leave a comment
I did not tell her the truth about what I really am…
The circumstances surrounding our introduction are unimportant. The only thing that matters is that Sasha Wilcox is my mate and she belongs to me. A night of unbridled passion sealed the deal, but before I could tell her the truth, she was gone. Days have turned into weeks and there is no way I can be without her. I must find her and bring her back to me. No one will stand in my way, especially not the one man who thinks he can steal her from me, Stefan Miller.
I want him so badly, and I have no idea why…
The last thing I should be doing is thinking about Remi Moretti: the green-eyed Italian man who kidnapped me and held me hostage for three days in Tuscany. I want to say that I feared for my life while under his guard, but that would be a lie. The truth is, in a moment of… weakness, I gave my body to him. He set it on fire, but I escaped, and now I need to move on with my life with Stefan, a great guy, who will make a great boyfriend. But why do I crave Remi’s touch? Why do I smell his intoxicating essence every time I breathe? And why do I sense his presence, even though he’s in Italy, and I’m in Miami?
**READER ALERT**
This story contains extremely passionate and descriptive sex scenes. Not suitable for readers under the age of 18 years, or those who may be offended by somewhat graphic descriptions of sexual encounters. This story also contains scenes which include expletives. Brooklyn’s characters exhibit real emotions and desires, and though she is their creator, she is also very sensitive to their needs and wants, and works in partnership with them to create their unique HEAs.
Series Alpha Series #1
Genre Multicultural & Interracial Romance, Paranormal Romance, Werewolf & Shifter Romance, Romance
Add To Goodreads TBR
Amazon eBook | Amazon Paperback
ABOUT BROOKLYN KNIGHT
Brooklyn Knight is a romance enthusiast who lives in the island of Bermuda and has been writing stories since she was a little girl. Over the years, her gift for designing and bringing characters to life has evolved, and she enjoys creating vivid, memorable characters and unforgettable situations. Her characters are thought-provoking and evocative; and they will draw emotion out of you like water from a well.
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New Release: Trois by Brooklyn Knight
January 4, 2019 / Kim Golden Malmgren / 1 Comment
Trois is the exciting conclusion to Brooklyn Knight’s The French Connection series; A BWWM, Multicultural & Interracial Romance. It is currently on sale now in eBook and paperback format.
He has three days to save her…
Dylan Hamilton has waited two years for this day to arrive; the day when Laila Renaud will become his wife. But the morning after his nuptials, he awakens, drugged and confused, only to discover that she has been snatched from his bed. And according to the man who has taken her, he has a limited amount of time to get her back. The clock is ticking… When Stefan Miller finds three Italian gangsters sitting in his suite the morning after Dylan’s wedding, it’s confirmation that his worst fears have come true. His brother’s antics have finally caught up with him and everyone else, including his love-interest, Sasha, who has been held ransom. Now with the clock counting down, he and Dylan must come up with a plan to save the women from impending doom.
Theoretically, it’s a simple operation: Get Stefan’s brother! Engage Dylan’s mob-boss of a mother! Save the girls!
But the rescue effort doesn’t go as smoothly as planned, especially when the puzzle pieces of Dylan’s traumatic past begin to connect. And especially when Stefan discovers that Sasha has fallen under the curious spell of her green-eyed kidnapper.
Series The French Connection, Book 3 of 3
Publisher Independently Published
Print Length 260 pages
Genres BWWM Romance, Multicultural & Interracial Romance, Contemporary Romance
Add on Goodreads https://www.goodreads.com/book/show/43313848-trois
A persistent pounding on the door ripped me out of sleep. I stirred, extra groggy from the fact that Laila had interrupted my slumber to talk about my parents and the announcement of her pregnancy. Her questions about my mother and father had angered me, but I’d hidden it from her, but when she’d told me she was carrying our baby, any negative emotions I’d been harboring fled.
Bang! Bang! Bang!
I reached over to the nightstand and gripped the clock, squinting. “It’s five-thirty,” I said to Laila. I reached over to pull her close, but when I realized the place in which she was laying was empty, my eyes popped open.
Bang! Bang!
“Lai…” I called into the darkness. My eyes shot to the en-suite bathroom, noticing the light bleeding from beneath the closed door.
Maybe she’d gotten up to use it. That was what happened to pregnant women. They peed more and they started throwing up. The sound of water running down the drain confirmed my suspicions.
The banging sounded again and I threw my legs over the edge of the bed, holding my head. That was when I realized the banging wasn’t only coming from the door. An aggressive thud was pounding against my brain, and I wondered what it could be from.
I looked at the empty glass on the night table and my brows drew. I turned to the door. “Who is it?” I shouted.
“Open the door, man!”
I stretched the tightness out of my limbs and made my way over, wondering what in the world would have Stefan so uptight and hammering my door down at such an ungodly hour.
“Lai,” I called again.
Still no answer.
I frowned, peeked through the peephole, and then stood back.
Stefan’s voice emitted from the other side of the barrier, and I couldn’t help but notice the alarmed edge in his tone.
I unlatched the door and ripped it open. Without hesitation, Stefan sprang inside, his eyes as wide as saucers.
“Stef, what the hell –”
“Where’s Laila?” He pushed past me and started searching the room as if he was looking for treasure.
I frowned, trying to understand what he was talking about, all the while, trying to ignore the throbbing in my head. “What do you mean, where’s Laila? She’s in the bathroom.”
Without saying anything, Stefan dashed for the bathroom and ripped at the door.
“What the hell are you doing?” I demanded rushing after him, I pulled him by the arm.
He ripped his arm away from me and glared at me. His eyes seeped with anger.
I grimaced. “What’s going on?” I demanded.
“Laila isn’t here,” he spat out.
My neck jerked forward. “Of course she is, she’s in the bathroom,” I reminded him. “She’s pregnant.”
Stefan rolled his eyes towards the ceiling and covered his face with his hands. “Jesus Christ…” he muttered.
“That’s not quite the response I was expecting,” I admitted trying to quell my frustration.
Stefan spun around and gripped me by the shoulders. “Dylan, Laila isn’t here,” he said again. Forcefully.
My body turned rigid. “What the hell do you mean –”
“Your boy, Anthony Moretti, the guy you told me not to worry about…”
He was talking, but I’d already ripped the bathroom door open, almost taking it off the hinges. I looked into the room, my eyes shifting frantically, searching for my wife who, true to Stefan’s word, was nowhere in sight. The only sign of movement was the water spilling from the gold faucet and disappearing down the drain.
My chest heaved and I stumbled until I had no choice but to lean over the basin. Water from the tap splashed onto me. Everything was spinning like it would in a funhouse, yet there was no doubt in my mind, I was in a house of goddamn horrors.
“Where’s my wife?” I gripped my temple before pulling myself away from the basin and storming through the Presidential Suite. I ransacked the place. I tore through every room, tossing the furniture like it was plastic. I marched out to the pool and scanned the area. With each examination, the fact that she was nowhere to be found pushed me further over the edge of sanity.
I screamed her name into the emptiness.
Stefan paced the floors next to me. His hand was clasped over his mouth. His eyes were narrow with rage. “He took Sasha too,” he muttered.
I spun around to look at him. “Who took Sasha?”
Stefan turned his eyes on me. “Fucking Moretti.”
I looked at the carpet, trying to make sense of what he was saying. “How do you know this?”
“Because I woke up in the middle of the night to Moretti and his boys in my goddamn room, and that’s when he told me. Silas…”
“What the hell does he have to do with this? I swear to God, I’ll kill him!” I listened, my entire body shaking as Stefan revealed the things Moretti had told him. Then he handed me the man’s business card, his despicable name embossed and emboldened.
Three days.
Moretti was demanding that we came up with two million euros in three days.
An angry breath escaped my nose. “Fine,” I spat. “He wants it in three days, he’ll have it three hours.”
Stefan nodded, realizing that my transferring the funds into Moretti’s account was the only way to put a stop to what was happening.
I raced around the room, looking for my cell phone. After a few minutes, which felt like a few hours, I found it on the floor underneath shards of a vase I’d destroyed.
I instructed SIRI to call my accountant and waited, operating on threads of patience, for him to pick up.
It went to voicemail.
I cursed.
“What happened?” Stefan asked, dry-washing his hands.
I gripped my bottom lip between my teeth and didn’t respond. Instead, I called the number again, this time taking care to punch each digit in manually.
It rang six times before clicking over to voicemail. In a fit of rage, I pitched the phone across the room and took my sweaty hair into my hands.
“Fuck!” My voice almost made the Swarovski chandelier hanging above us to crash to the floor.
Stefan raked his hands through his afro and pulled out his own cell phone.
“Who are you calling?” I asked, shoving my hands on my hips.
“It sure as hell ain’t my investment banker,” he muttered. “The hell if I have two million goddamn euros sitting in an account.” He pressed the phone against his ear. “I’m calling my brother.”
“If you don’t have it, he sure as hell doesn’t,” I spat. My eyes burned and I rubbed them, trying to erase the sensation.
I needed to slow down.
I needed to calm down and think rationally.
Ma belle fille and Sasha had been abducted. I had no idea how it had happened or when. In fact, the more I thought about it, the more I realized I couldn’t remember much of what had transpired over the course of maybe three or four hours.
Stefan turned away from me and I listened for a second as he threw a slew of curse words into the cell phone receiver.
I pinched the bridge of my nose, trying to practice my solution-focused mantra, the one I used every day at my firm.
“I need to call Moretti,” I mumbled to myself. My cell phone, now shattered on the ground, would be of no use. I rushed to the landline on Laila’s side of the bed and tried to ignore my heart, crushing inside of my chest. I held the business card Stefan and given me and tried to steady my shaking hands as
I dialed the numbers.
Within seconds, Moretti answered.
I dropped onto the bed and pressed the phone hard against my ear. “Tell me this is a fucking joke!” I shouted into the phone.
“Dylan Hamilton.” The sound of his vocals made me want to spit.
“Where is my goddamn wife?” He’d barely finished his greeting before I was barking the demand. “I swear to God, I’m two seconds away from alerting INTERPOL. They’ll have you apprehended and your ass will be in jail quicker than you can fucking blink!”
“A few things,” Moretti responded casually. “INTERPOL is not a threat to me. Yes, I have been barred from various jurisdictions, but that does not inhibit my movements. Surely, you are aware of this. Secondly, if I were you, I would think long and hard about alerting anybody about anything. Your precious wife and her friend would be dead before the authorities ever caught up with me and my men. And thirdly…” he sighed. “You should practice being less emotional. You are a savvy business tycoon who cuts million-dollar deals by the hour. You, of all people should know that emotion has no place when it comes to business. Let us talk like the adults that we are.”
I gritted my teeth and tried to settle myself as best I could. In some ways he was right. My only concern was getting my wife and Sasha back. If that meant playing Moretti’s sick game, I should at least hear the rules.
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New Release Alert: Hate Notes by Vi Keeland and Penelope Ward
A standalone romance novel published by Montlake Romance
By: New York Times Bestselling Authors Vi Keeland & Penelope Ward
Release Date: Tuesday, November 6, 2018
It all started with a mysterious blue note sewn into a wedding dress.
I’d gone to sell my own unworn bridal gown at a vintage clothing store. That’s when I found another bride’s “something old.”
Stitched into the lining of a fabulously feathered design was the loveliest message I’d ever read: Thank you for making all of my dreams come true.
The name embossed on the blue stationery: Reed Eastwood, obviously the most romantic man who ever lived. I also discovered he’s the most gorgeous. If only my true-love fantasies had stopped there. Because I’ve since found out something else about Mr. Starry-Eyed.
He’s arrogant, cynical, and demanding. I should know. Thanks to a twist of fate, he’s my new boss. But that’s not going to stop me from discovering the story behind his last love letter. A love letter that did not result in a happily ever after.
But that story is nothing compared to the one unfolding between us. It’s getting hotter, sweeter, and more surprising than anything I could have imagined.
Something new.
But I have no idea how this one is going to end . . .
Photo/Cover Details:
Photo Credit: Tijana Vukovic
Model: Dusan Susnjar
Teasers by: Luna Sol
To read an excerpt of Hate Notes, click here.
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Please Note: Because Hate Notes is published by Montlake Romance, a division of Amazon, the ebook and paperback will only be available on Amazon. If you are an Amazon Prime or Kindle Unlimited member, the Hate Notes ebook will be free for both Prime and KU members on release day!
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Vi Keeland
Vi Keeland is a #1 New York Times, #1 Wall Street Journal, and USA Today Bestselling author. With millions of books sold, her titles have appeared in over a hundred Bestseller lists and are currently translated in two dozen languages. She resides in New York with her husband and their three children where she is living out her own happily ever after with the boy she met at age six.
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Penelope Ward is a New York Times, USA Today and #1 Wall Street Journal bestselling author.
She grew up in Boston with five older brothers and spent most of her twenties as a television news anchor. Penelope resides in Rhode Island with her husband, son, and beautiful daughter with autism.
With over 1.5 million books sold, she is a twenty-time New York Times bestseller and the author of over twenty novels.
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Other Books From Vi & Penelope:
Co-written Novels
The Rush Series (2 Book Series)
Rebel Heir
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British Bedmate
(Previously titled: Dear Bridget, I Want You)
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Cocky Bastard
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Stuck-Up Suit
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Playboy Pilot
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Mister Moneybags
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By:Vi Keeland & Dylan Scott
Left Behind (A Young Adult Novel)
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Vi’s Standalone Novels
Vi’s Upcoming January 2019 Release
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Sex, Not Love
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Beautiful Mistake
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The Baller
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Life on Stage series (2 Standalone Books)
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MMA Fighter series (3 Standalone Books)
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Worth the Chance
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Worth Forgiving
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Worth It All (Complete Fighter Series)
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The Cole Series (2 Book Serial)
Belong to You
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Penelope’s Standalone Novels
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Gentleman Nine
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Drunk Dial
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Mack Daddy
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RoomHate
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Stepbrother Dearest
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Neighbor Dearest
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Jaded and Tyed (A novelette)
Sins of Sevin
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Jake Undone
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Jake Understood (Jake #2)
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My Skylar
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New Release Alert: Who We Were by Melissa Collins
Release Blitz for Who We Were by Melissa Collins
A M/M contemporary romance
Amazon – https://mc-author.com/WWW_MC-Amazon
Apple Books – https://mc-author.com/WWW_MC-Apple
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*If you read with Apple, Nook, Kobo, or Google Play – this title will be removed from these retailers and going into KU on Sunday, so grab your copy today!
Who We Were…
Two awkward teenagers – the loner and the nerd, trying to find our place in the world. Paired in wood shop, we knew nothing of each other, except that we wanted to know everything. Then one life altering moment changed it all and we were left with shattered dreams and broken hearts.
Two grown men – braver and smarter than we used to be, trying to heal the damage from that irrevocable moment. Even though the past was behind us, dead and buried long ago, we found it impossible to move on without ripping open the scars of our deep wounds.
With twelve years of unanswered questions fueling our desperate need for the truth, we must figure out if who we were will destroy who we are.
Add to your TBR on Goodreads here.
Melissa is having a giveaway on Facebook for 2 – $25 Amazon gift cards! Check it out here.
Melissa Collins has always been a book worm. Studying Literature in college ensured that her nose was always stuck in a book. She followed her passion for reading to the most logical career choice: English teacher. Her hope was to share her passion for reading and the escapism of books to her students. Having spent more than a decade in front of a classroom, she can easily say that it’s been a dream.
Her passion for writing didn’t start until more recently. When she was home on maternity leave in early 2012, she read her first romance novel and her head filled with the passion, angst and laughter of the characters who she read about it. It wasn’t long before characters of her own took shape in her mind. Their lives took over Melissa’s brain and The Love Series was born.
Website | Amazon | Facebook | FB Reader Group | BookBub | Twitter | Goodreads | Pinterest
@kj_charles @allieiswriting Someone school @LozzaFox since he doesn't seem to know any of this. 8 hours ago
@bravesmimi @GMB @piersmorgan @susannareid100 And he still continues his racist rants, this time mocking China. Som… twitter.com/i/web/status/1… 8 hours ago
@tashalharrison Say NO to toxic family members. 8 hours ago
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Aurora, Illinois Planned Parenthood Protest Aug 8-22-2015
jennifer / August 22, 2015
August 22, 2015 protest Against Planned Parenthood:
The intersection where you turn right to get an abortion.
Entrance to the hedged Planned Parenthood Compound
Where: Planned Parenthood, 3051 E. New York St., Aurora, IL 60504
Planned Parenthood Detail:
Categories: Hospital & Medical Center, Doctor & Clinic, Obstetrics & Gynecology, Abortion, Pregnancy Information, Infertility Counseling, Abortion Information, Abetting…Mutilation, Eugenics, Selling of fetal body parts, Dr. Mengele’s human experiments, First-degree murder, Human sacrifice, Dehumanization, Atrocities…
As mentioned…
I arrived at 9 am. By 10 am the protest signs were no longer available. By 10 am the crowd had so increased that there was no estimate count of protestors. Many people were waiting to sign “in” on the Pro-Life Action League contact sheet. I’ll post the count and videos as they become available.
Across from the hedged Planned Parenthood compound protestors were praying and reading Scripture. As protestors walked the sidewalk along E. New York St., many were repeating the Rosary.
Notice the lack of law enforcement? These protestors are salt-of-the-earth Tea Party kind of people; the ones that the Left loves to denounce as they do all their own aborted children.
(I am working/fighting with the WordPress program, trying to get the following .movs to appear as regular videos. In the meantime please click on them.)
“We Protest and We Pray”: https://kingdomventurers.files.wordpress.com/2015/08/pph-protest-8-22-2015-070.mov
“Love is Our Mission”: https://kingdomventurers.files.wordpress.com/2015/08/pph-protest-8-22-2015-074.mov
“Awaken a Nation”: https://kingdomventurers.files.wordpress.com/2015/08/pph-protest-8-22-2015-067.mov
9:00 am CST-The protest began along E. New York St. at Oakhurst Dr. intersection, Aurora, IL
People signing up on the Pro-Life Action League contact sheet.
“Planned Parenthood is Bad for Aurora”
Looking east towards the intersection of E. New York St. and Oakhurst Dr. (Planned Parenthood is south of E. New York St. on Oakhurst Dr. surrounded by tall hedges and an apartment complex across the street.
Looking from the Speaker’s corner toward the Planned Parenthood Compound. Protestors stood across from the compound and also behind me along E. New York Street.
Corner of Oakhurst Dr. and E. New York St., Speakers corner is on the left. Planned Parenthood’s compound is a left turn past an empty field-from where children never come home.
Secure Planned Parenthood Compound (highly secure, but not for a child!)
Back of Planned Parenthood Compound w/dumpster
Middle class ‘nice’ neighborhood apartments across from Planned Parenthood Compound. The majority of Aurora residents are minorities.
Across from the entrance to Planned Parenthood Compound
Children got involved blowing up balloons that said “LIFE”.
Planned Parenthood Volunteers and security
“Child Sacrifice for Profit is Demonic” Corner of Eola Rd. and E. New York St., Aurora, IL
“I Regret My Abortion”
A family protests together along E. New York Street
“Abortion Babies Lives Matter”
Protect the a priori Natural Rights of the Unborn. Love the Unborn as you love yourself, women. You were once Unborn. Humanists and atheists will abort per their ideology of mortality for some and not for others.
“We Protest and We Pray”:
August 22, 2015 in Abortion, Christianity, Current events 2015, Uncategorized. Tags: abortion, morality, Planned Parenthood, Pro-Life Action League
@PPact @PPFA @HeyPP Atrocities and the Chasm of Caedas
SCOTUS’ Judicial Reviews-A Wax Museum
The Final Protest
← EPA’s gross negligence at Gold King Mine includes disappearing 191 incident photos from their website
Don’t Show Up. Be There! →
4 thoughts on “Aurora, Illinois Planned Parenthood Protest Aug 8-22-2015”
sheeniac says:
I’m concerned over the frequent usage of dismembered babies/ victims of abortion. Ironic given that I changed my view because of them, but I made the choice to see the images, as opposed to seeing them just driving down the street.
The pictures were/are very graphic but necessary, I believe. We live in a non-logocentric world where words don’t have the same effectual ‘value’ as pictures. Just look at what’s on TV.
Having sad this, I cannot look at the videos posted on LI because of their graphic depictions. And, because of evil linked to banality: a group of people who sell baby body parts over lunch.
Awesome coverage! Too bad the press wasn’t there-cowards. I felt it an honor to participate in this march. There were some negative responses from a few individuals in their vehicles passing by- the thumbs down, the finger, and some guy screaming from his window something I couldn’t even understand. But the majority of passersby tooted in agreement with the stance of pro-life. Like I said it was a privilege to take part in this historical moment.
Yes, I also felt it a great privilege to participate. And, yes, there were those passers-by who made it known that they hated the fact that we were protesting…against ABORTION!?!
There were many church groups involved. Many were mentioned from the speaker’s corner. Sadly, I didn’t see any Greek Orthodox priests or Rabbis in attendance.
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Active tuberculosis in children who received INH chemoprophylaxis
Ikeda Kazushige, Sugimori Mitsuko, Kawasaki Kazuteru, Kurokawa Hiroshi, Kijimoto Chuichi
Twelve children who developed active tuberculosis even after receiving isoniazid (INH) chemoprophylaxis were seen at Tokyo Metropolitan Children's Hospital from 1982 through 1991. All cases received INH more than 9mg/kg/day, except for one case in which the amount of INH administered at the referring hospital was unknown and Streptomycin was administered together with INH. The age of starting INH prophylaxis ranged from 2 months to 13 years, and the age at which clinical symptoms and/or laboratory evidences of active tuberculosis were first manifested ranged from 4 months to 18 years. Five patients developed active tuberculosis after the completion of chemoprophylaxis and patients during chemoprophylaxis, with the first presentation ranging from primary complex (seven), chronic pulmonary tuberculosis (two), tuberculous meningitis (two), and tuberculous pleuritis (one). None of the Mycobacterium tuberculosis resistant to INH was isolated.Reviewing these patients, eleven cases had at least one of the following factors: (1) age less than two years old (2) infectious sources expectorated more Mycobacterium tuberculosis (3) delay in starting INH. Above factors should be considered in initiating INH chemopro phylaxis and subsequent follow-up of the patients.
kekkaku(tuberculosis)
https://doi.org/10.11400/kekkaku1923.67.653
Chemoprevention
Meningeal Tuberculosis
Urban Hospitals
Streptomycin
Active tuberculosis in children
Chemoprophylaxis
Primary complex
Tuberculin skin test
Kazushige, I., Mitsuko, S., Kazuteru, K., Hiroshi, K., & Chuichi, K. (1993). Active tuberculosis in children who received INH chemoprophylaxis. kekkaku(tuberculosis), 67(10), 653-658. https://doi.org/10.11400/kekkaku1923.67.653
Active tuberculosis in children who received INH chemoprophylaxis. / Kazushige, Ikeda; Mitsuko, Sugimori; Kazuteru, Kawasaki; Hiroshi, Kurokawa; Chuichi, Kijimoto.
In: kekkaku(tuberculosis), Vol. 67, No. 10, 1993, p. 653-658.
Kazushige, I, Mitsuko, S, Kazuteru, K, Hiroshi, K & Chuichi, K 1993, 'Active tuberculosis in children who received INH chemoprophylaxis', kekkaku(tuberculosis), vol. 67, no. 10, pp. 653-658. https://doi.org/10.11400/kekkaku1923.67.653
Kazushige I, Mitsuko S, Kazuteru K, Hiroshi K, Chuichi K. Active tuberculosis in children who received INH chemoprophylaxis. kekkaku(tuberculosis). 1993;67(10):653-658. https://doi.org/10.11400/kekkaku1923.67.653
Kazushige, Ikeda ; Mitsuko, Sugimori ; Kazuteru, Kawasaki ; Hiroshi, Kurokawa ; Chuichi, Kijimoto. / Active tuberculosis in children who received INH chemoprophylaxis. In: kekkaku(tuberculosis). 1993 ; Vol. 67, No. 10. pp. 653-658.
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title = "Active tuberculosis in children who received INH chemoprophylaxis",
abstract = "Twelve children who developed active tuberculosis even after receiving isoniazid (INH) chemoprophylaxis were seen at Tokyo Metropolitan Children's Hospital from 1982 through 1991. All cases received INH more than 9mg/kg/day, except for one case in which the amount of INH administered at the referring hospital was unknown and Streptomycin was administered together with INH. The age of starting INH prophylaxis ranged from 2 months to 13 years, and the age at which clinical symptoms and/or laboratory evidences of active tuberculosis were first manifested ranged from 4 months to 18 years. Five patients developed active tuberculosis after the completion of chemoprophylaxis and patients during chemoprophylaxis, with the first presentation ranging from primary complex (seven), chronic pulmonary tuberculosis (two), tuberculous meningitis (two), and tuberculous pleuritis (one). None of the Mycobacterium tuberculosis resistant to INH was isolated.Reviewing these patients, eleven cases had at least one of the following factors: (1) age less than two years old (2) infectious sources expectorated more Mycobacterium tuberculosis (3) delay in starting INH. Above factors should be considered in initiating INH chemopro phylaxis and subsequent follow-up of the patients.",
keywords = "Active tuberculosis in children, BCG, Chemoprophylaxis, Primary complex, Tuberculin skin test",
author = "Ikeda Kazushige and Sugimori Mitsuko and Kawasaki Kazuteru and Kurokawa Hiroshi and Kijimoto Chuichi",
doi = "10.11400/kekkaku1923.67.653",
journal = "Kekkaku",
publisher = "Japanese Society for Tuberculosis",
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AU - Kazushige, Ikeda
AU - Mitsuko, Sugimori
AU - Kazuteru, Kawasaki
AU - Hiroshi, Kurokawa
AU - Chuichi, Kijimoto
N2 - Twelve children who developed active tuberculosis even after receiving isoniazid (INH) chemoprophylaxis were seen at Tokyo Metropolitan Children's Hospital from 1982 through 1991. All cases received INH more than 9mg/kg/day, except for one case in which the amount of INH administered at the referring hospital was unknown and Streptomycin was administered together with INH. The age of starting INH prophylaxis ranged from 2 months to 13 years, and the age at which clinical symptoms and/or laboratory evidences of active tuberculosis were first manifested ranged from 4 months to 18 years. Five patients developed active tuberculosis after the completion of chemoprophylaxis and patients during chemoprophylaxis, with the first presentation ranging from primary complex (seven), chronic pulmonary tuberculosis (two), tuberculous meningitis (two), and tuberculous pleuritis (one). None of the Mycobacterium tuberculosis resistant to INH was isolated.Reviewing these patients, eleven cases had at least one of the following factors: (1) age less than two years old (2) infectious sources expectorated more Mycobacterium tuberculosis (3) delay in starting INH. Above factors should be considered in initiating INH chemopro phylaxis and subsequent follow-up of the patients.
AB - Twelve children who developed active tuberculosis even after receiving isoniazid (INH) chemoprophylaxis were seen at Tokyo Metropolitan Children's Hospital from 1982 through 1991. All cases received INH more than 9mg/kg/day, except for one case in which the amount of INH administered at the referring hospital was unknown and Streptomycin was administered together with INH. The age of starting INH prophylaxis ranged from 2 months to 13 years, and the age at which clinical symptoms and/or laboratory evidences of active tuberculosis were first manifested ranged from 4 months to 18 years. Five patients developed active tuberculosis after the completion of chemoprophylaxis and patients during chemoprophylaxis, with the first presentation ranging from primary complex (seven), chronic pulmonary tuberculosis (two), tuberculous meningitis (two), and tuberculous pleuritis (one). None of the Mycobacterium tuberculosis resistant to INH was isolated.Reviewing these patients, eleven cases had at least one of the following factors: (1) age less than two years old (2) infectious sources expectorated more Mycobacterium tuberculosis (3) delay in starting INH. Above factors should be considered in initiating INH chemopro phylaxis and subsequent follow-up of the patients.
KW - Active tuberculosis in children
KW - BCG
KW - Chemoprophylaxis
KW - Primary complex
KW - Tuberculin skin test
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DO - 10.11400/kekkaku1923.67.653
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Laurette Long
Get passionate… about books, cabbages and kings
Dear Santa, please bring me lots of books 17 December 2019
Coming Home To Haworth: Charlotte Brontë’s ‘little book’. 23 November 2019
Marx, Engels, and Christmas at Villa Julia (or: why you’re not going to be reading my next book with your turkey and mince pies) 26 October 2019
The Lion, forty years after: remembering Joseph Kessel. 11 August 2019
It’s the weekend! Time to change the quilt covers (OR Caring and Sharing with your Loved One) 27 July 2019
Laurette on Dear Santa, please bring me lots of books
Denise Baer on Dear Santa, please bring me lots of books
Annika Perry on Dear Santa, please bring me lots of books
Hot Basque
"The writing is frothy and witty with some gorgeously inappropriate turns of phrase." Amazon review
‘What I enjoyed the most is that Ms Long's writing conveys her love for people and that her passion for life transpires throughout the book.’ Review of Harold Hamilton, Amazon reader.
Amazon reviews: ‘The Bronte landscape is beautifully described’ ‘Once this ended, I felt an emptiness because I didn’t want to let the characters go’ ‘enchanting…pulls one into the story’ ‘a homage to romanticism’ ‘Great descriptions of characters and places and a fabulous read - now when is book four published??’
In this collection of 25 blogs Laurette Long talks about her experiences as a writer and country-dweller, the joys of life in France, and her passion for reading.
Dear Santa, please bring me lots of books
The Rylands Library, home to a lot of books
In one of my notebooks of random jottings I have written the following: ‘In 2018, 63 million books were sold in the run-up to Christmas.’ Not sure where I got this factoid or if it’s true. But in case it is, and you’re wondering just which of the 63 million to buy, here are my suggestions, spotlighting five authors whose books I particularly enjoyed this year.
My first ‘Dear Santa’ book list appeared in 2015, the year I started blogging. It featured three authors, all male, all writing in one particular genre-the detective thriller–and all starring the type of complex, edgy, dodgy, sexy, hero-but-anti-hero homme fatal I have been unable to resist ever since falling for those men in trench coats as a teenager.
This year it’s the ladies who get the laurel wreaths, five of them, not a private eye in sight, each one impressive for different reasons. Sheila Patel made me laugh, Jill Kearney made me cry, Helena Whitbread made me bow my head in reverence, and Pamela Allegretto and Deborah Swift took me on incredible journeys. Here’s how they did it, starting with the last two. (Click on their names to go straight to the author page).
Roman vista
Cities are fascinating places. I lived in a flat bang in the middle of Toulouse for ten years, until the exhaust fumes and seedy bar downstairs lost their charm. But although home is now a beloved four-house hamlet deep in rural France, the allure of the great metropolis still lingers. Allegretto and Swift bring to life two iconic cities at momentous periods in their history: WW2 Rome and 17th century London. The authors share an ability to conjure up the startling realism that a dreamer sometimes experiences, swept away on a night journey where, as in a film, the perspective shifts between panoramic aerial shots to voyeuristic close ups. From vistas encompassing houses, bridges, spires, monuments, wide rivers, vast skies and surrounding countryside, the camera zooms in to the tobacco stains on the villain’s teeth, the nuance of grays in a puddle, the whole accompanied by a full-on, sensory onslaught of smells, colours and clamour. As I found out more about these authors’ backgrounds, I was struck by another thing they had in common–the way those backgrounds influenced their work.
frescos unrolling
Pamela Allegretto is an American artist of Italian descent. As I started to read her book, Bridge of Sighs and Dreams, the scenes unrolled like frescoes across the screen of my mind. It’s 1938 and we are in an idyllic cherry orchard in southern Italy, home of the Lombardi family for hundreds of years. But this enduring, bucolic way of life is about to be shattered, signalling the end of an era and the beginning of an exhausting struggle by one woman, Angelina Rosini, to protect her young daughter in a country torn apart first by the poisonous ideology of Fascism, then by the invading armies of the Allies. The action moves from the countryside to the cobbled alleyways and ancient monuments of Rome, where Allegretto transposes her ‘pictorial eye’ to the written page, creating an arresting canvas of a war-torn city where the inhabitants, in particular Jews and resistance fighters, live in constant fear and deprivation. In the foreground, two women battle it out on a personal level in a combat as full of primitive emotions as the classical dramas of antiquity: Angelina, the artist heroine, and her driven, harpy-like sister-in-law, Lidia. Who will be the winner?
The Great Fire of London1666 anonymous courtesy wikimedia commons
From Rome to London, where a different but equally deadly foe, is spreading terror – the plague. In Deborah Swift’s trilogy, Women of Pepys’ Diaries, the famous diarist is getting up to all sorts of mischief and mayhem. The author started her career in the theatre, working as a set and costume designer, and there’s a dramatic immediacy in her writing similar to that we experience at a live performance. Indeed her third book is about a woman who becomes an actress, Elizabeth Knepp, who, like the other strong female leads, is based on a real person mentioned in the diaries. Pepys, the man of the title, and inspiration for the novels, is an inveterate womaniser who gets up to the sort of sexist manipulation and exploitation typical of the time, but the way in which he is portrayed by Swift endows him with a sort of irresistible attraction for the reader, much like that of Becky Sharp in Vanity Fair. All the books are terrific reads but my favourite is A Plague on Mr Pepys, with its heroine Bess Bagwell, who sees her ambitions for herself and her husband, Will, crumble under the random blows of fate and the devious machinations of her brother-in-law, Jack. As her circumstances become more and more desperate, she is obliged to turn to the powerful Pepys in an attempt to save herself and Will. The psychology of their relationship, and the way it develops, is gripping. Bess teeters on a dangerous seesaw in which the necessity of reeling in the only man who can help must be counter-balanced by her desire to keep him at arm’s length. Will she succeed?
The Piece Hall, Halifax
From London and Rome to the north of England. My next two authors hail from my birthplace, the west riding of Yorkshire (chauvinist, moi? Heh heh). Helena Whitbread is the only non-fiction author of the five, and she has already featured here, in my May blog, along with her 19th century soulmate, Anne Lister, who became world-famous this year in the TV series Gentleman Jack. But Anne’s story may never have reached such a wide audience had it not been for the astonishing devotion and talent of the woman who said of her efforts: ‘I was just the back-street scribe.’ In 1983, Whitbread was looking for a research topic for a Ph D. Wandering into the Halifax Archives, she happened upon the diaries of a 19th century local landowner and secret lesbian, Anne Lister. ‘From that day,’ she writes, ‘I … found myself engaged in a literary, historical and cultural adventure…Halifax, for me, became two different towns. Physically I moved around…twentieth century Halifax. Mentally, I lived in the small nineteenth century town.’ She set out to reveal the Anne hidden in the diaries, decoding and transcribing 27 volumes and 4 million words, of which one sixth are in code with no punctuation. She writes: ‘Curiosity, allied to the thrill of an intellectual challenge, gripped me.’ But her achievement does not stop there. The two books which resulted from her research, The Secret Diaries of Miss Anne Lister and No Priest But Love, consist of her final selections from the diaries themselves linked by explanatory passages and further clarified by detailed footnotes. The sensitivity and justesse of her selections and the lucid passion of her explanatory passages communicate a striking empathy with a woman who lived 150 years previously and who, on the surface, could not have been more different from her 20th century amanuensis.
‘Have you noticed you never see a cow laugh?’ This was one of the more notoriously sibylline pronouncements by my Yorkshire grandmother one Saturday as we took her on a drive through the countryside. Those cows had obviously not come across Sheila Patel’s series of books set in contemporary Bradford, The Magic Vodka Wardrobe. This is definitely not Bradford as you know it, and definitely not as my Yorkshire grandmother would have known the grimy old mill town. But, along with the cows, Grandma would have been singing and dancing and shaking from head to toe (or horn to hoof) with mirth at ‘Ar Sheila’s’ depiction of the Singh family and life in their corner shop, backed up by a mind-boggling cast of friends and neighbours who would make Damon Runyon’s eyes water: Mad Mush Martha, Tattoo Tony and his Rottweiler, Knobhead, Joginder the goat, Graham the pigeon, Dammit Janet, Gyppo Bob, and Guru the Wedding Horse, to name but a few. They feature in a series of outrageously hilarious vignettes which have the same freshness, originality and addictive surrealism as those of Monty Python’s Flying Circus back in the 70s.
Is there a glitter ball in there?
Patel was the seventh child of a traditional Punjabi family who grew up in the same period as The Flying Circus (is there a link?) 1970s Britain. Her writing, she says, was inspired by ‘all the funny things that Indians do daily to adapt to the British way of life’. Centre stage are the Singh family: Father, Mother, her two sisters Lady Fatima and Sheila (‘short short skirts, four husbands’) and the three daughters Kirsty (rich husband), Shaz and Trace ( ‘both accountants, both thin, with no scary moles and nice cars’ but- to Mother’s chagrin- still husbandless). Another important character is Bachitaar but to meet him we have to step out of the fourth dimension of life in Patel’s Bradford and enter a fifth dimension, accessible only through a magic wardrobe, consisting of a 70s disco bar complete with glitter ball and non-stop musical soundtrack (Douglas Adams, anyone?). Bachitaar, complete with turban, can be found behind the bar serving up endless vodka shots while lending a sympathetic ear to Sheila, Trace and Shaz who take refuge in the wardrobe when life, love, bamboo bikes, spam samozas and the news headlines all get too much. Until the time comes when Santa can supply magic wardrobes to all of us, don’t hesistate to join Sheila and the girls in theirs!
Finally, after the laughs, the tears. It’s a well-known fact that no Christmas is complete without a Miracle on 34th Street.
Jill Kearney, like Sheila Patel, was inspired to write by her real-life experiences. These included being a dog rescuer and in-home care provider. Her book The Dog Thief and Other Stories, set in a rural pocket of Washington State, features humans who are poor and dispossessed, animals who share a similar fate, and those often-hapless individuals who try to help out. In this divided society with its ‘separate realities’-the affluent owners of oceanside homes at one extreme, the survivalists and hippies running meth labs and puppy mills in the woods at the other – it would be easy to moralise, and hold our noses at people like Beverley, an MS sufferer who rejects the relative comfort of the reservation in favour of a squalid existence in a collapsed trailer with a swarm of feral cats, and who spends her social security checks on alcohol and cat food. Good Samaritan neighbour, Jim, inwardly railing at her stubbornness, tries to save her from total decrepitude, attempting to fix her broken toilet, hauling out overflowing buckets of excrement while literally holding his nose (‘the smell…smacked him in the sinuses.’). Writing in a deceptively low-key, unsentimental style, Kearney gets her message across by delivering unexpected knee chops. She possesses that rare knack of picking out the perfect detail in a myriad of possibilities, the one tiny raindrop that reflects an entire, staggering world, halting us in our tracks as we read, making us laugh out loud or burst into uncontrollable tears. Her alter ego, Elizabeth, features in several of the tales, driven to desperate devices (such as stealing dogs from abusive owners) in order to right wrongs, while simultaneously trying to grasp the meaning of her own unorthodox life, where poignant remembrance of time past vies with a recognition of the importance of seizing the beauty of the moment. Like that other quintessentially American writer, Carson McCullers, Kearney the story teller pulls off the magic trick of getting us to empathise with her variety of creatures great and small, to suspend our judgement, to enter into their lives with wonder and humility and vow to do better ourselves.
And what better Christmas message could there be than that?
Happy Christmas from the Cowshed
To bookworms around the world Joyeux Noël et Bonne Année from the Cowshed!
Book news, book news, books news!!!!!!
Terry Tyler published her new book in the Project Renova series, Blackthorn, in November.
Paulette Mahurin has just announced the release of her latest book, The Old Gilt Clock, about WW2 Dutch resistance fighter, Willem Arondeus.
Miss Moonshine is back in her emporium with Christmas goodies…
And John Dolan has been invited to take part in a multi-author boxed set of crime thrillers to release in 2020, Notorious Minds. Watch this space.
Coming on my blog in 2020:
A visit to the magnificent John Rylands library in Manchester, more on the Anne Lister theme with a visit to Lightcliffe Church cemetery where Lister’s ‘wife’ Anne Walker is buried…. along with twenty or so of my ancestors! Also an update on my abandoned project Christmas at Villa Julia, which is now busy turning itself into a new historical series, The Etcheverrias, starting in 1898 with A Wedding in Provence… too nervous to say any more in case the Muse goes on an extended holiday without leaving a forwarding address 😉
Posted on 17 December 2019 Categories ThoughtsTags Christmas books, Deborah Swift, Helena Whitbread, Jill Kearney Rome, London, Sheila Patel Pamela Allegretto, the Plague, WW212 Comments
Copyright © 2016 By Laurette Long
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Stephanie Levin
Email | Press Inquiries
Stephanie Levin is a member of LPI’s Equitable Resources and Access team where she is working to translate research on school finance and resource allocation to inform practice and policy. She also conducts research to better understand inequities across schools and identify remedies to redress these inequities.
Levin has over 10 years of experience as a mixed-methods researcher and project manager focusing on educational equity; school finance and budgeting; the impact of federal, state, and district policies on teacher effectiveness and student outcomes; and teacher and school leader professional learning opportunities. Most recently, she designed and led studies evaluating the implementation and impact of teacher professional learning opportunities. Prior to her work in education research, Levin was a consultant, policy analyst, and budget analyst addressing issues shaping the experiences of children and families in urban settings.
Stephanie received a Ph.D. in Education Policy from the University of Pennsylvania’s Graduate School of Education, an M.P.P. from Harvard’s Kennedy School of Government, and a B.S. in Architecture from the Massachusetts Institute of Technology.
All Topics Accountability and Improvement Deeper Learning Deeper Learning: College, Career & Civic Participation Deeper Learning: Curriculum, Instruction & Assessment Deeper Learning: School Organization & Design Early Childhood Learning Educator Quality Educator Quality: Professional Learning Educator Quality: Recruitment & Retention Educator Quality: Evaluation & Career Development Equitable Resources and Access The Every Student Succeeds Act (ESSA)
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Showing 1 - 3 of 3 resources
Principal Turnover: Insights from Current Principals
Caitlin Scott
High quality principals are essential to students' educational opportunities and outcomes, but principal turnover is an ongoing problem in the United States. A 2017 survey of public school principals found that approximately 18% had left their position since the previous year. In high poverty schools, the turnover rate was 21%. This brief includes insights, experiences, and expertise from school leaders on the challenges associated with being a school principal and strategies to address those challenges.
Topics Educator Quality, Educator Quality: Professional Learning, Educator Quality: Recruitment & Retention, Educator Quality: Evaluation & Career Development
LPI Experts Discuss Impact of Principal Leadership on Teacher Shortages in New Podcast
Jessica Cardichon
In the National Governors Association's new School Leadership Hot Topics Podcast series, LPI’s Jessica Cardichon and Stephanie Levin discuss new reports on principal turnover, the impact of principal leadership and support on teacher shortages, and ways that states are using the Every Student Succeeds Act to develop and support principals and school leaders.
Topic Educator Quality
School principals are responsible for maintaining a positive school climate, motivating school staff, and enhancing teachers’ practice. They are vital to ensuring teachers’ success in the classroom and students’ success, but one in five principals leaves their school each year and the numbers are worse in schools in underserved communities. Inadequate preparation, poor working conditions, insufficient salaries, lack of authority, and high-stakes accountability policies are among the drivers of principal turnover that must be addressed.
Topics Educator Quality, Educator Quality: Recruitment & Retention, The Every Student Succeeds Act (ESSA)
Preparing Teachers to Support Social and Emotional Learning
Well-implemented programs designed to foster social and emotional learning (SEL) are associated with positive outcomes, ranging from better test scores and higher graduation rates to improved social behavior. This LPI study examines San Jose State University's successful teacher preparation program and a California school district's in-service program that incorporate SEL instruction in an effort to inform policymakers, practitioners, and teacher educators about the components of strong, SEL-focused teacher preparation and development systems.
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Ignorance is bliss legal definition of Ignorance is bliss
https://legal-dictionary.thefreedictionary.com/Ignorance+is+bliss
(redirected from Ignorance is bliss)
Also found in: Dictionary, Thesaurus, Idioms, Encyclopedia.
IGNORANCE. The want of knowledge.
2. Ignorance is distinguishable from error. Ignorance is want of knowledge; error is the non-conformity or opposition of our ideas to the truth. Considered as a motive of our actions, ignorance differs but little from error. They are generally found together, and what is said of one is said of both.
3. Ignorance and error, are of several kinds. 1. When considered as to their object, they are of law and of fact. 2. When examined as to their origin, they are voluntary or involuntary, 3. When viewed with regard to their influence on the affairs of men, they are essential or non-essential.
4.-1. Ignorance of law and fact. 1. Ignorance of law, consists in the want of knowledge of those laws which it is our duty to understand, and which every man is presumed to know. The law forbids any one to marry a woman whose husband is living. If any man, then, imagined he could marry such a woman, he would be ignorant of the law; and, if he married her, he would commit an error as to a matter of law. How far a party is bound to fulfill a promise to pay, upon a supposed liability, and in ignorance of the law, see 12 East, R. 38; 2 Jac. & Walk. 263; 5 Taunt. R. 143; 3 B. & Cresw. R. 280; 1 John. Ch. R. 512, 516; 6 John. Ch. R. 166; 9 Cowen's R. 674; 4 Mass. R. 342; 7 Mass. R. 452; 7 Mass. R. 488; 9 Pick. R. 112; 1 Binn. R. 27. And whether he can be relieved from a contract entered into in ignorance or mistake of the law. 1 Atk. 591; 1 Ves. & Bea. 23, 30; 1 Chan. Cas. 84; 2 Vern. 243; 1 John. Ch. R. 512; 2 John. Ch. R. 51; 1 Pet. S. C. R. 1; 6 John. Ch. R. 169, 170; 8 Wheat. R. 174; 2 Mason, R. 244, 342.
5.-2. Ignorance of fact, is the want of knowledge as to the fact in question. It would be an error resulting from ignorance of a fact, if a man believed a certain woman to be unmarried and free, when in fact, she was a married woman; and were he to marry her under that belief, he would not be criminally responsible. Ignorance of the laws of a foreign government, or of another state; is ignorance of a fact. 9 Pick. 112. Vide, for the difference between ignorance of law and ignorance of fact, 9 Pick. R. 112; Clef. des Lois Rom. mot Fait; Dig. 22, 6, 7.
6.-2. Ignorance is either voluntary or involuntary. 1. It is voluntary when a party might, by taking reasonable pains, have acquired the necessary knowledge. For example, every man might acquire a knowledge of the laws which have been promulgated, a neglect to become acquainted with them is therefore voluntary ignorance. Doct. & St. 1, 46; Plowd. 343.
7.-2. Involuntary ignorance is that which does not proceed from choice, and which cannot be overcome by the use of any means of knowledge known to him and within his power; as, the ignorance of a law which has not yet been promulgated.
8.-3. Ignorance is either essential or non-essential. 1. By essential ignorance is understood that which has for its object some essential circumstance so intimately connected with the: matter in question, and which so influences the parties that it induces them to act in the business. For example, if A should sell his horse to B, and at the time of the sale the horse was dead, unknown to the parties, the fact of the death would render the sale void. Poth. Vente, n. 3 and 4; 2 Kent, Com. 367.
9.-2. Non-essential or accidental ignorance is that which has not of itself any necessary connexion with the business in question, and which is not the true consideration for entering into the contract; as, if a man should marry a woman whom he believed to be rich, and she proved to be poor, this fact would not be essential, and the marriage would therefore be good. Vide, generally, Ed. Inj. 7; 1 Johns. h. R. 512; 2 Johns. Ch. R. 41; S. C. 14 Johns. R 501; Dougl. 467; 2 East, R. 469; 1 Campb. 134: 5 Taunt. 379; 3 M. & S. 378; 12 East, R. 38; 1 Vern. 243; 3 P. Wms. 127, n.; 1 Bro. C. C. 92; 10 Ves. 406; 2 Madd. R. 163; 1 V. & B. 80; 2 Atk. 112, 591; 3 P. Wms. 315; Mos. 364; Doct. & Stud. Dial. 1, c. 26, p. 92; Id. Dial. 2, ch. 46, p. 303; 2 East, R. 469; 12 East, R. 38; 1 Fonb. Eq. B. 1, ch. 2, Sec. 7, note v; 8 Wheat. R. 174; S. C. 1 Pet. S. C. R. 1; 1 Chan. Cas. 84; 1 Story, Eq. Jur. Sec. 137, note 1; Dig. 22, 6; Code, 1, 16; Clef des Lois Rom. h.t.; Merl. Repert. h.t.; 3 Sav. Dr. Rom. Appendice viii., pp. 337 to 444.
<a href="https://legal-dictionary.thefreedictionary.com/Ignorance+is+bliss">Ignorance</a>
agister
Brief for Petitioner
Captain or sea captain
circumstantial evidence
constructive trust
Descent and Distribution
There truly are times when ignorance is bliss, Miss.
Are you a gossip-friendly gal pal? what would you do if your BFF became the target of gossip gone wild? Would you jump to your friend's defense or let loose lips fly? Find out! (Quiz)
They say that ignorance is bliss. If that is true, then I have seen many happy people in the past.
Heartening lack of anti-English rant
"I guess that proves that ignorance is bliss. Frankly, I miss the bliss."
Authorities say this could never happen, but still, the Luddite whale lovers believe that, in this case, ignorance is bliss.
Moby Chip
Bas Gaakeer, is a composer and a musician who is taking part in the Ignorance is Bliss performing arts show.
Bas Gaakeer to host guitar workshop at Darb 1718
From fearless to clueless, Tom Hanks proves that ignorance is bliss - and Oscar-worthy - in reactionary slapstick (stupid is good, smart is bad) that's as bogus as Gump's chocolatebox philosophy.
Ignorance is bliss, perhaps, but knowledge is your right, so don't give it away because once it's gone it's gone.
Welcome to 1984; LETTERS
When that happens, the adage, 'When ignorance is bliss, it's folly to be wise,' invariably comes to mind.
Show the truth signs
Ignorance is bliss until it dumps you into trouble.
Hog to Hog
He said: "Sometimes, ignorance is bliss and that seems to be the case this time.
We'd be fools to ignore 'formidable' Wales - Scott
Idem agens et patiens esse non potest
Idem est facere
Idem est nihil dicere et insufficienter dicere
Idem est non probari et non esse; non deficit jus
Idem est scire aut scire debet aut potuisse
Idem non esse et non apparet
Idem semper antecedenti proximo refertur
Idem sonans
identification parade
Identitas vera colligitur ex multitudine signorum
Identitate nominis
Idiota inquirendo
If a student is accused of something, can they see picture evidence?
If someone is arrested and not on probation, can police take blood?
Ignis judicium
Ignominy
Ignorantia excusatur
Ignorantia facti excusat
Ignorantia judicis est calamitas innocentis
ignorantia juris neminen excusat
Ignorantia legis neminem excusat
Ignorantia terminis ignoratur et ars
Ill fame
illegal alien and school sports
illegal contract
illegal entry by police
illegal evidence
Illeviable
Illicite
Illud quod alias licitum non est necessitas facit licitum
Illusory appointment
Illusory Promise
ignominies
ignominiously
ignominiousness
Ignomy
ignorable
ignorable coordinate
ignoramuses
Ignorance is no excuse.
Ignorance of a Rival
ignorance of law
Ignorance of the law is no excuse
Ignorance of the law is no excuse for breaking it
Ignorance of the law is no excuse for breaking it.
Ignorance of the law is no excuse.
Ignorance-based view
ignorances
Ignorant Black Kidz
Ignorant habit
Ignorant Moron
Ignorantia juris non excusat
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John Hunt | author
Filed under Columns
The courage of St. Thomas More
John Hunt applauds Legatus members for their profound courage in defending the faith . . .
John J. Hunt
Cour-age, noun, the quality of mind or spirit that enables a person to face difficulty, danger, pain, etc., without fear; bravery.
Each year Legatus honors a number of outstanding members. I had the privilege of presenting the 2012 Courage in the Marketplace award to the Weingartz family (Detroit Northeast Chapter) and to Bill and Andy Newland (Denver Chapter). Christopher and Mary Anne Yep of the Chicago Chapter had previously received the Courage in the Marketplace award at our 2013 Summit.
These Legates exhibited extraordinary courage for their bold decisions to file lawsuits against the U.S. government in defense of their religious freedom, which is under attack in the Patient Protection and Affordable Care Act (ObamaCare). As I became aware of the paths these individuals followed in making such a decision, I was particularly impressed that their lawsuits were filed on behalf of their companies, all family-owned businesses. In varied ways, the lives of these courageous individuals — and the businesses they founded — will likely be forever changed by their decisions.
Facing difficulty, danger, pain, etc., without fear — that’s courage. Legates in the 21st century are called by God to be courageous in our daily lives, sometimes in small and insignificant ways; sometimes in life-changing ways. Courage can present itself in a number of ways, but it will present itself.
Personal courage to “do the right thing in business transactions, ethically and morally” is an opportunity that is part of the activities of a functioning marketplace.
Corporate courage for business leaders means recognizing the burden we bear for our employees and associates – to provide a fair wage, benefits and working conditions that contribute to elevating their quality of life.
Spiritual courage means understanding that each of us has to grow in love for and service to Our Lord, a relationship that is a lifetime in the making but is cultivated by a day-by-day struggle punctuated whenever possible by Mass, rosary, prayer, etc.
Cultural courage means defending the truths of the Natural Law and the teachings of our faith visibly and boldly in a way that exhibits the depth of our love for the truth.
St. Thomas More is a model for all who cultivate courage as a virtue. While being trusted and respected by King Henry VIII, More would not compromise the truth and teachings of the Catholic faith. The saint would say that he was “the king’s good servant, but God’s first.” Might we say as much?
JOHN HUNT is Legatus’ executive director. He and his wife Kathie are charter members of Legatus’ Chicago Chapter.
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More in Columns, Executive Director
Dealing with same-sex attraction
Daniel Mattson writes to those who have children struggling with same-sex attraction . . . [caption id="attachment_8667" align="alignleft" width="257"] Daniel...
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Yes, Al Gore, There Is Such A Thing as Global Warming
By Len Penzo
Many people continue to say there is no such thing as global warming.
My wife Tipper says, ‘If you see it in Len Penzo dot Com, it’s so.’
So please tell me the truth; is there such a thing as global warming?
Al Gore.
2100 West End Avenue, Nashville, TN, 37203.
Al Gore, those people are wrong. They have been affected by the skepticism of a skeptical age. They disagree with Cap and Trade and they find it ludicrous that carbon dioxide — a trace gas ultimately critical for all life on earth – is now considered a pollutant. But the minds of those that refuse to buy in to global warming, Al, whether they be respected scientists, enlightened environmentalists, or common folk who do their own independent research, are little. In this great universe of ours these people are mere insects, ants, in their intellect, as compared with the boundless world about them. At least as measured by the true intelligence of global warming alarmists like yourself, capable of grasping the whole of truth and knowledge.
Yes, Al Gore, there is such a thing as global warming. It exists as certainly as love and generosity and devotion exist. Never mind that the earth has been cooling since 1998 while carbon dioxide levels have continued to rise. Never mind that theglobal warming models you like to reference are critically flawed. Alas! How dreary would be the world if there were no global warming? It would be as dreary as if there were no Al Gores. There would be no childlike faith, then no poetry, no oppressive socialist ideology to make tolerable our existence.
Not believe in global warming! You might as well not believe in fairies! You might get Barack Obama to hire ACORN to watch all the chimneys on Christmas Eve to catch Santa Claus, but even if they did not see Santa Claus coming down, what would that prove? Nobody sees global warming yet either, but that is no sign that there is no global warming. The most-real things in the world are those that neither children nor men can see. Did you ever see fairies dancing on the lawn? Of course not, but that’s no proof that they are not there. Nobody can conceive or imagine all the terrible anti-capitalist bugaboos there are unseen in the world — although global warming is a good one, Al.
You may tear apart the baby’s rattle and see what makes the noise inside, but there is a veil covering the unseen world which not the strongest man, nor even the united strength of all the strongest men that ever lived, could tear apart. Only faith, fancy, poetry, socialism, radicalism, romance, environmental propaganda, and utopianism can push aside that curtain and view the supernal beauty and glory beyond. Is it all real? Ah, Al Gore, in all this world there is nothing else real and abiding for those that truly believe.
No global warming! Thank God it exists, Al, for ignorance is bliss! It is the world’s best hope for the elimination of economic growth and the downfall of capitalism. A thousand years from now, Al Gore, nay, ten times ten thousand years from now, as long as there are committed socialists and environmentalists around polluting Earth’s atmosphere with their every exhaled breath, I suspect global warming will continue to be a thorn in the side of freedom loving people everywhere.
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10 Comments October 15, 2009
Finnegan says
Joe Plemon says
When real evidence is scarce, even Al’s faith can flag at times. I am sure your response to his letter will encourage him to once again be a true believer. As you say, “ignorance is bliss”.
Seriously, some of the best satire I have read. I love it.
@Finnegan, @The Bobo: Thanks, guys!
@Bret: Did you see the comparison going around the web a few years ago comparing W’s non-White House home to Gore’s? W’s was modest in size and completely environmentally friendly while Gore’s was this huge mansion that was anything but. I think you can still find the piece on Snopes – it was a true story.
@Joe: Thank you. I was just surprised he even bothered to write to me! 😉
Watch Movies Online says
Worldwide climate change patterns of recent years have started to negatively affect the Himalayas and the people living in this region, their socio-economic development, biological diversity and other sectors. The risk of floods, landslides, glacier erosion, drought, deforestation and other natural calamities has greatly increased. – Zora
And there is nothing we can do about it, Zora… That’s all part of the natural cycles of the Earth.
The BoBo says
Absolutely brilliant!
Bret says
I think Al Gore needs to put his own house in order, before he tells America what to do.
Between his mansion, entourage and private jets, he will waste more energy this year than most of us will use in our lifetimes.
Talk is cheap, but action is priceless.
Financial Samurai says
I was just in Al Gore’s building (St. Regis) this week, and asked for him, but didn’t see him!
There’s no global warming, not this year! 8 feet of snow in Tahoe already, brrrrrrrr.
That’s great news for the ski industry! 🙂
led tail lights for cars says
At any rate Al Gore is right about climatic change, correct? Or is he wrong? He says it was man-made, not just earth’s standard cycle over thousands of years. Ya think?
Leave a Reply to Len Penzo Cancel reply
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Domestic wood species – think oak, maple, cherry, birch and walnut – never go out of style and are usually easy to find and purchase at a fair price point. Lately, however, due to lumber shortages and mill delays, we’re seeing that some domestic species can cost as much as exotic ones. It’s no surprise then that there’s been an increase in interest in the exotic species of wood flooring.
What makes wood exotic?
Exotic hardwood is simply wood that is sourced outside of North America. Most exotic species are imported from South America (especially Brazil), the Caribbean, Australia, Africa and Asia.
What are the advantages of exotic wood?
Exotic wood species are especially durable, dent resistant and rank high on the Janka hardness scale. This makes them ideal for high-traffic areas such as entrances and hallways. Above all, exotic wood is known for its natural beauty, no staining required! Colors are dramatic and rich, with striking and unique grain patterns.
When it comes to exotic wood, make sure you purchase from a reliable source. Often, exotics are harvested and imported illegally. At Macon Hardwood, we source all of our wood from suppliers that maintain sustainable practices and meet the requirements outlined in the Lacey Act.
Here is a just selection of exotic wood flooring we offer at Macon Hardwood:
Brazilian Cherry (Jatoba)
Brazilian cherry, known for its hardness and rich color, is one of the world’s most popular exotic flooring species. As it wears and gets exposed to light, Brazilian cherry wood will darken, turning from a salmon red to a deep, reddish brown hue.
Brazilian cherry flooring is ideal for high-traffic areas in both residential and commercial properties.
Santos mahogany, which is native to South America, is one of the most hard and durable wood flooring species. In fact, it is 200% harder than Douglas fir and 50% harder than maple. Santos mahogany has a dark reddish brown color with striped figuring in quarter sawn selections.
Santos mahogany is ideal for high-end residential and commercial installations and ornamental design applications.
Tigerwood features deep orange hues and various dark stripes that mimic the appearance of the famous jungle cat. A photosensitive species, tigerwood will darken with exposure to light and eventually achieve a more uniform look.
Tigerwood is a great choice for contemporary interiors that want to make a bold, dramatic statement, but it’s especially known as a fine choice for decking. That’s because tigerwood is low maintenance, durable and naturally resistant to rot and decay.
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Home » Topics » Addictions
Fentanyl Addiction and Withdrawal
Updated 15/09/2015 | John Lee
Fentanyl is an extremely potent synthetic opiate – many times more powerful than morphine. The drug is recommended for use in patients with extreme cancer pain, who also show a tolerance to the analgesic effects of less potent narcotic pain relievers.
Fentanyl in all forms is extremely dangerous to anyone inexperienced with opiates. The potency of the drug makes the risk of a fatal overdose a real possibility for anyone who does not already have a significant tolerance to opiates. Fentanyl is a schedule 2 narcotic – a drug with the highest possible risk for abuse, addiction, and fatal overdose.
Fentanyl is most typically administered either in transdermal patches, such as Duragesic, or through the lollipop like Transmucol Actiq. Fentanyl is a widely abused medication, and can be bought at the street level. Street sales of Fentanyl include legitimate pharmaceutical medications that have been diverted, and Fentanyl produced in illegal laboratories.
Fentanyl - The Effects
Fentanyl induces a powerful euphoria and sense of well being; in addition to its analgesic properties. The effects of the drug are very similar to heroin, although the half life of Fentanyl is shorter.
The Risks of Fentanyl Overdose
Fentanyl is an incredibly powerful medication, and should never be given to anyone who is not already opiate tolerant. An inexperienced user trying Fentanyl risks overdose, respiratory depression, and death.
Fentanyl is also not recommended for anyone with a weakened respiratory system, regardless of their tolerance level on comparative opiates, and as such is not recommended for post surgical pain management.
The risks of overdose increase greatly when the transdermal patches are abused. The transdermal patches are designed to deliver a constant and steady dosage of the medication, over a long period of time. The medication can be extracted and injected in larger doses for a more intense experience. There is enough Fentanyl in a Duragesic patch to kill, and this method of abuse has proven quite deadly.
Fentanyl is also sometimes mixed with other street drugs, to intensify the effects. Common mixtures include Fentanyl and cocaine or heroin. This method also greatly increases the risks of a fatal overdose.
Fentanyl Withdrawal and Detox
Fentayl is as potent as heroin, and also as addictive. Users taking Fentanyl for more than a few days risk a serious physical dependency, and a very uncomfortable period of withdrawal.
Withdrawal symptoms of Fentanyl will include:
Withdrawal symptoms will subside within a week, most people will need to detox from Fentanyl under medical supervision, and with medications for symptoms management.
An alternative to a "cold turkey" detox involves the use of Suboxone or methadone, in opiate replacement therapy. Substituting either methadone or Suboxone for the Fentanyl allows addicts to participate fully in daily life, free from withdrawal symptoms, as they slowly taper down off of the substitute narcotic.
Fentanyl addicts who abuse the medication recreationally will often need addiction counseling and therapies to learn how to avoid a relapse to Fentanyl, or a substitute drug of abuse.
Fentanyl is dangerous and potent, and inexperienced recreational users should never attempt the drug. The risks of a fatal overdose are very real.
Helpful Reading:
Precipitated Withdrawal May 24, 2010 | Methadone & Subutex/Suboxone
If you try to abuse Suboxone or you take it for the first time before you're feeling opiate withdrawal symptoms, you can go into precipitated withdrawal - which is a sudden and intense medication caused entry into opiate withdrawal symptoms. Learn how Suboxone can cause precipitated withdrawal and learn how to make sure you'll never have to experience it!
Read the complete article
What is Methadone? May 24, 2010 | Methadone & Subutex/Suboxone
Although methadone has long been a somewhat controversial and unfortunately stigmatized medication, it’s also the most effective medication for the treatment of opiate addiction. A daily dose of methadone removes all drug cravings and withdrawal symptoms from even the most severely dependent opiate abuser and lets you get your life back on the right track, free from the pulls of temptation. Methadone has a low entry cost and is easily available throughout America.
Stages of Suboxone Treatment May 24, 2010 | Methadone & Subutex/Suboxone
Treatment with Suboxone occurs in three phases, the induction, stabilization and maintenance phases. Learn what happens in each phase and how long it takes to move through these stages of care.
UK Addiction Treatment - Call 0800.808.5765
© 2020 Choose Help. Some rights reserved.
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Oblivion Song By Kirkman & De Felici Vol. 3
Oblivion Song By Kirkman & De Felici
In the wake of the world’s second transference event, everything is different. Collects OBLIVION SONG #13-18
Image - Skybound
Lorenzo De Felici Annalisa Leoni
Action/Adventure Supernatural/Occult
A decade ago, 300,000 citizens of Philadelphia were suddenly lost in Oblivion. The government made every attempt to recover them, but after many years, they gave up. Nathan Cole...won't. He makes daily trips, risking his life to try and rescue those still living in the apocalyptic hellscape of Oblivion. But maybe...Nathan is looking for something else? Why can't he resist the siren call of the Obl
A brand-new ongoing series from the acclaimed bestselling creative team of Old Man Logan and Green Arrow! The lives of a reclusive young man obsessed with a conspiracy in the city's trash, and a washed-up Catholic priest arriving in a small town full of dark secrets, become intertwined around the mysterious legend of The Black Barn, an otherworldly building that is alleged to have appeared in both
Die!Die!Die!
SUPRISE RELEASE! Robert Kirkman's latest release from Image Comics, Die!Die!Die!. Blood will flow, Bullets will fly and the mayhem will never end, Die!Die!Die! brings all the action you could ever want.
Outcast by Kirkman & Azaceta
NEW HORROR SERIES FROM THE WALKING DEAD CREATOR ROBERT KIRKMAN! Kyle Barnes has been plagued by demonic possession all his life and now he needs answers. Unfortunately, what he uncovers along the way could bring about the end of life on Earth as we know it.
Sci-fi and horror collide in this new series from the co-creator of CHEW! Mankind has colonized the galaxy, but during our interstellar travels, we discovered a terrifying secret out in the Outer Darkness of space. Join Captain Joshua Rigg and the crew of the starship Charon as they encounter demonic possessions, hauntings, cosmic horror, and more! All-star writer JOHN LAYMAN (CHEW) and ar
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Robin (1993-2009) #23
Robin (1993-2009)
Neron transforms Killer Moth into the monstrous Charaxes, whose dinner plans include a healthy portion of Robin! Meanwhile, the Dark Knight becomes involved in the financial troubles of Ariana's family.
Superhero Mystery Drama Crime
With Batman at his side or off on his own, Tim Drake protects the streets of Gotham by night while simultaneously trying to lead a normal teenage life by day. Writer Chuck Dixon returns once more to the Boy Wonder Tim Drake—this time for the young hero's very own ongoing series!
Robin II: Joker's Wild (1991)
The Joker escapes from Arkham Asylum and finds his gang being led by Mister Freeze! With the Dark Knight unavailable, it’s up to Robin to follow the clues and retrieve the Clown Prince of Crime!
Tim Drake stars in his first own limited series written by Chuck Dixon, with art by Tom Lyle and Bob Smith. The Boy Wonder flies without the Dark Knight detective for a mystery of his own as he heads to Paris for training...and finds himself at odds with the Ghost Dragons!
Nightwing (1996-2009)
Dick Grayson stars in his very own series as the high-flying acrobatic super-hero Nightwing! After years of serving alongside the Dark Knight detective through the streets of Gotham City, Nightwing branches off on his own as the sworn protector of Bludhaven!
Nightwing tries to free Batman from Arkham Asylum, only to discover why he's really trapped inside. Meanwhile, Jeremiah Arkham succumbs to his heritage of madness! "The Last Arkham" part 3.
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Some Interesting Notes in Polygraph History
25th July 2017 by Jason Hubble News 0 comments
The following data are excerpts published by the “International Society For the Detection of Deception,” in their news bulletin as indicated: August 1948: First edition inviting members. The Society was formally incorporated at Bismarck, ND on 12/30/47.
September 1948. The US Air Force purchased its first polygraph instrument with Major William Wiltberger, former Director of the Police School, San Diego, CA giving an initial demonstration…… 44 applications for membership received…..Sergeant William Morse, a recent graduate of the Keeler Institute assigned to the Scientific Investigations Laboratory, Carlisle Barracks, PA……First application from US Armed Forces received – Major Harold G.Creyts, Chief, CI Section, MP School, Carlisle Barracks, PA….
October 1948: India Police to use polygraph with Puttappa Shivabasppa having graduated from the Keeler Institute…. 40 additional applications for membership received…..First woman polygraph operator joins, Mrs. Jane D. A. Wilson of Madison, WI…Helpful hint – a member suggested using scotch tape to secure the instrument pens when taking the machine on a trip…Society becomes truly International with members in Germany, Japan, Philippines and India.
November 1948: Society reaches 92 members…..Hint: Member suggests placing a small shelf on the back of the subject chair for keeping the attachments when not in use….Another member suggests putting hooks on the back of the chair to hang them…..
December 1948: Interesting case from the US Army involved the Kronberg Jewel Case. During heavy bombing of Germany in 1944, the Hesse family decided to put the family jewels in a safe place, which was to bury them in the basement of Kronberg Castle near Frankfort. The Castle was not bombed and was taken over by the Americans as a rest center. In the fall of 1945 a GI who was looking for hidden treasure as related by servants, found a hollow
sounding space in the basement floor. He broke the cement, dug down a short distance where he found a lead lined wooden box. Inside were packages, each carefully wrapped and labeled. Opening some of the packages he could not believe his eyes for they contained the Hess jewels consisting of bracelets, tiaras, diadems, rings, pins, watches, etc. set with diamonds, rubies, emeralds, pearls and other precious stones. The stunned GI called the OIC, Capt.
Kathleen Nash. She ordered them taken to her room where all traces of them disappeared. Nash wanted her friend Col. Jack Durant to see the jewels. He called his assistant Maj.David F. Watson, and the three of them decided to keep the jewels for themselves. To shorten the story the Prince came to get some of the jewels for the Princess to wear at her wedding but found them missing and an investigation was started by Army CID. Nash and Durant were on terminal leave and they were recalled to duty. Capt. Nash did not comply and was found with her husband at the La Salle Hotel in Chicago and was taken into custody by the MP on June 3, 1946. Nash, who had married Col. Jack Durant, was given a polygraph test by Leonarde Keeler and confessed implicating her then-husband Capt. Jack Durant and Maj. Watson. Some of the jewels she had hidden at her sister’s home in Hudson, WI were recovered by CID. Col. Jack Durant was brought in for interrogation and agreed to take a polygraph test. He was not told his wife confessed. He was given peak of tension regarding the location of the jewels and responded to some of them being buried in Virginia and Wisconsin. He refused to take additional tests; however, his interrogation continued. He asked and made several phone calls saying that it “looked good” and they could probably get some of the jewels back. Later that same evening he led CID to the Illinois Central Train Station where jewels were recovered from a locker with the key hidden above a light fixture over a public telephone booth. The jewels were loose stones removed from larger pieces of the Hesse family jewels that had been broken up and the jewels removed. Captain Nash Durant and Col. Durant were returned to Europe for Courts Marshal with Nash Durant sentenced to 5 years and Col. Durant sentenced to 15 years. Maj. Watson was also convicted by Court Marshal and was given three years. The bulk of the jewels were recovered at Hudson, WI and Chicago. Some were found in Ireland, where they had been sent by Maj. Watson, and some in California, Virginia and Washington, DC. An unknown number were never recovered and are still missing……
A case involved the theft of six Army 45 caliber automatic pistols was solved after a polygraph by WO C. N. Joseph. The name of the perp was withheld and four weapons were initially recovered but two had been sold to an “unknown man.” After a polygraph test the perp confessed the “unknown man’ was in fact his father. It was also noted that this individual also confessed after he joined the Army he has stolen an automobile in NY and attempted to steal three diamond rings…..
by Jason Hubble10th June 20190 comments
UK Polygraph Association
by Jason Hubble1st January 20200 comments
Liverpool Lie Detector Test UK Polygraph Testing by Jason Hubble
by Jason Hubble6th June 20170 comments
The Value of Polygraph Research
by Jason Hubble7th August 20170 comments
Lie Detectors In The White House
Ancient Ways Of Detecting LiesPrevious Post
Lie Detectors UK Jason Hubble claims Love Island Lie Detector Tests were all fake.Next Post
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Excerpt from Prince of the Dark Vol II. of the Demons of Dreams Saga, Chapter I, Chapter II, Chapter III
A snow storm of the century blew with fury outside and any reasonable person watched the goings-on only from a window from inside his four warm walls.
“Are you still going out, Mo?”
“I have a date.”
Christine looked at him with her slightly crazed look, which was a clear sign that she was once again hyped-up on pills and alcohol. The various therapies that she had gone through already were all for nothing. Meanwhile, Morris had given up searching the cupboards for hiding places and flushing the little mood enhancers down the toilet. She always found new means and ways to acquire re-placement ones anyway.
He dressed in a black jacket and a wool cap, gave his wife a kiss on the forehead and grabbed the car keys.
“Where are you are driving to?”
“To a private opening in Soho.”
She nodded and wished him a lot of fun.
Art was his great passion and he never missed an opportunity to go to museums, exhibitions or similar events and admire the work of artists.
Today’s exposition had particularly aroused his interest. The topic was the intermediate phase of death. He was curious as to what the artist thought regarding this subject.
It looked like that he was not the only one interested in this theme because the gallery’s vast space was overflowing with life. The guests were sometimes standing so close to the pictures that it was almost impossible to view them undisturbed. At first glance however, they were all rather disappointing and did not come even remotely close to reality. But how could a pathetic little human being know how it should look.
He grabbed a glass of wine from a tray and listened to the conversations of bystanders. Every-one seemed to have his own story linked to the topic of death.
“My mother recently died … At the end she looked really transparent.”
“With my father I knew it already weeks beforehand. I could see it in his eyes.”
“They say that they are being met … by those that have gone before.”
“Have you read the report on Steve Jobs’ death? He smiled when it was his time.”
“One could really not have tackled the topic any more boringly. Even a fly’s turd is more interesting than this. Shit, it’s only ten o’clock.”
He smirked and looked for the person that voiced his thoughts so accurately. She stood next to a man and they toasted the press photographer. Long black hair lay like glossy liquid silk on her back and when she turned around he saw her stunning face and a fascinating pair of bright, piercing green eyes.
“Dr. Eltringham!” Louise Rush, a colleague from the hospital rooted herself directly in front of him and blocked his view of the beautiful woman.
Since their first encounter in the operating room, the almost five foot nine physician adored him and tried to engage in conversation at every suitable and unsuitable occasion. Before his marriage she would have been an easy and welcoming target, but at the present he had no need. In addition, women that offered themselves like this and whose intent was so obvious, bored him to death.
She pointed to a painting behind him and chattered away uninhibited and without hesitation. Morris looked around again for the little beauty, but she was lost somewhere in the crowd.
Dr. Rush had only Morris’s good manners to thank for the fact that he simply did not turn away and leave. Letting the nonstop babble flow in one ear and out the other, he nodded occasionally at the appropriate times. His eyes wandered again and again over the heads of the guests looking for the pair of jade-green eyes.
“… don’t you think so, Dr. Eltringham?”
“I agree completely.”
At last he had found her. Smooth and gracefully she moved among the crowd and shot photos with her camera. Her upright posture suggested that she had enjoyed many years of dance lessons.
All the nearby women kept throwing him lustful glances, but she ignored him, which attracted him even more. “Would you excuse me?” Too much chatter gave him headaches. He left the doctor standing alone and walked past a couple of art works feigning interest, paused for a little while, listened to the asinine comments and then moved slowly towards the exit. Fresh air was needed urgently. Normally he would have left the opening after a half an hour, at the latest, but yet hung around for a while and went later to his car in order to wait for the end of the event.
When the last guests had finally left the gallery it took less than ten minutes until the lights were extinguished and the beautiful young woman appeared on the street with a blonde. Hoping that the two would not stop at a bar or a nightclub even though the night was still young, he started his engine and followed them slowly from the shadows of the houses to a parking garage. There he watched as the two women parted from each other and rolled down his window. The night wind carried their voices softly to him and as he had hoped, he caught her name. Leia. Speaking it in a low voice, it sounded like a note in a sad piece of music.
Patiently he waited until she drove out the exit and followed her at a moderate distance up to Bushwick. Meanwhile, it had started snowing again. The thick snowflakes swirled around the moving cars and lay like cake icing on roofs, roads and parked cars. The white carpet gave the night a strange light that in other parts of the city were certainly romantic. In this area it only highlighted the blemishes.
Bushwick was known for its thriving drug trade and its Hispanic population that accounted for eighty percent of the majority.
On the house walls young people had sprayed their wild graffiti; street lights had been smashed and submerged some corners into an eerie darkness. She lived in a rather uncomfortable and unsafe neighborhood. In his opinion it was far too dangerous for a young woman of her class to wander alone at night.
They drove past a small park where a few gang members were playing football with a tin can on the fringes. One of them, a small short-legged Puerto Rican pointed to Leia’s car and said something to the others.
Leia was completely oblivious to anything in the outside world. From what he could observe by her bobbing head and drumming hand on the steering wheel was that she was listening to loud music. The car stopped next to a large dumpster a few streets further. She probably lived in one of the old factory buildings that had been rendered habitable and converted into lofts. Still she had no clue as to the danger that was surrounding her.
He turned onto the side street and stopped several hundred feet from her front door, observing how Leia exited her car in his rear view mirror. While looking in her purse for something, three creepy young guys stepped around the corner and immediately circled their quarry.
Morris took out two batons from under the seat, put one in the left and the other in his right pocket and got out of the car. He pulled his black wool cap down low over his face as he neared the small group.
One of the Latinos grabbed the bag and chucked the contents onto the street. He discovered her wallet and with a satisfied grunt thrust a handful of dollar bills into his pocket. The other cretins were in the mood for something else. The biggest pushed the frightened defenseless woman against the wall while holding a knife to her throat. Frozen with horror, she made no sound as he probed under her skirt.
They were so preoccupied with their victim that they didn’t notice Morris approaching them. There was only a slight clunk as the batons extended and a snapping sound as one hit a guy’s leg and the other almost simultaneously slammed down into the face of another. A nasty crunch told him that he had broken the bones of both. The third and shortest stared up at him stunned and quickly scampered away.
Morris picked up the keys from the street, threw them at Leia and waited until she had disappeared through the doorway. When he knew she was safe, he glanced at the pathetic figures at his feet. Filled with fear neither made a sound. Morris could hear the panting of the third guy that had bolted around the corner. He launched into a sprint and spied him in no time. A well-targeted throw of the baton knocked down the fugitive and Morris seized him by the collar, dragged him upright and pushed him up against the wall. Small condensed clouds of breath came in bursts out of his mouth and the eyes of his opponent widened in terror-stricken fear.
The blood in Morris’s veins ran like hot oil. It was a sure sign that he was going to transmogrify. His irises changed color to a deep black and sharp talons dug into the throat of the young guy.
“If I ever see any of you on this road again and people are hurt or robbed, I’ll make sure that you’ll wish that you had never been born, is that clear?” he hissed and reached into the pocket of the panting Latino to retrieve the crumpled dollar bills. No sooner had he released him from his claw-like grip, he took off across the road and disappeared into the dark unlit park.
The other two were still lying on the ground in front of the snow-covered entrance. The one with the broken jaw was now unconscious; the other–holding his leg–writhed in pain. However it did not keep him from uttering a threat, which he paid for by receiving another blow to his other leg. This would discourage the rat from preying on helpless people. Morris picked up Leia’s scattered belongings and put everything back into the purse, which he then laid on top of the dumpster.
Light was now on in two lofts. He made out the delicate shape of Leia behind one of the top windows. She was completely distraught and was talking to someone on the phone. Retracting the batons, he went with a knowing smile back to his car.
When he arrived home, his wife was asleep on the sofa. On the table stood an empty bottle of wine and the television was on. A familiar image to him, as he often came home from a night shift and found her like this.
He covered the huddled body with a blanket and looked at Christine worriedly. How swiftly she had faded in his hands. The once young, beautiful and rosy face of the thirty year old had suddenly aged a decade in the last year. But that was not the only change; her soul was damaged too by her dying love. The one time cheerful uncomplicated young woman now became irritable and moody. She had started drinking and taking drugs for reasons that not even she could explain. But he knew why and his mother had warned him not to enter into a marriage with a mortal woman.
He switched off the TV, walked into the bedroom and laid down on the bed.
Again and again the bright green eyes that had not even once noticed him were on his mind. The urge to see her again was intense. Confident that Christine would not wake up again he went to the window, went deep inside himself and spread his wings.
The entire city with its glittering jewels lay beneath his feet as he glided silently through the darkness. No one was visible on the cobblestone street in front of Leia’s house. The young creeps had either been picked up or hit the road by themselves. Satisfied, he noticed that her purse still lay untouched on the dumpster. Softly he landed on the snowy roof of the old brick building and peered through the skylight.
There she lay asleep, only half-covered between rumpled, dark gray silk sheets. The outline of her slim body only confirmed that he was not mistaken; she was picture perfect. He forced his way into her subconscious and moved between the images in her dream.
She just finished processing the evening in the gallery and was in the middle of giving new color of her own with a brush and palette in hand to the paintings. A portion of them were already completed. The artist himself was sitting in a cage and spat angry insults about her smears. Morris found the scene very amusing.
The colorful, bright pictures that were supposed to illustrate a world between life and death were painted over by Leia’s dark, wild brush strokes and obelisk-like structures.
“Interesting,” he remarked calmly.
Grim-faced, she turned towards him ready to defend herself, but when she saw him her expression softened immediately. “Have we met?”
She studied him with narrowed eyes, but could not remember nor place him, which didn’t surprise him a bit. “Why interesting?”
“Do you imagine the transition like that?”
“Transition means that you are on the way to something. Heaven is light, warmth and love while hell is dark, cold and malevolent. So why should the transition be full of light if the destination is still uncertain?”
“That sounds logical in a certain way.”
“It does not just sound, it is logical.”
“The transition could also be colored. Like a mixture of light and dark. How would it be with dark blue or purple?”
She looked at him curiously. “I don’t like purple.”
“That’s naturally an argument,” he said laughing.
The brush was dipped again noisily into the black paint and smeared over the oil paintings some more.
Abruptly, Leia opened her eyes and looked around confused. Her eyes roamed to the skylight. For a moment he thought that she had discovered him, but looking back down at her, she was writing by the light of her reading lamp, with weary half-opened eyes, a few lines in a book: the man with the beautiful ice-blue eyes. She giggled quietly, closed the book and put it back on her nightstand.
He waited until she was asleep and then pushed off and ascended, higher and higher, until disappearing into the clouds, where he turned a few circles and went on his way back home.
Most people forgot their dreams immediately upon waking and even though the memories sometimes came back like déjà vu, they were quickly forgotten again. He had wandered through many dreams; had sweetened many women’s sleep, but only a few had aroused his interest. Leia excited him and he would see if and how far she would let him into her heart.
Exactly at six he woke up. His wife was lying in bed facing away from him in the fetal position. During the early morning hours she must have laid down next to him shortly after he went to bed. When they were newly in love she had always pressed herself close to him and was only able to fall asleep when he lay beside her. That had changed as well as many other things.
Rising quietly, he went into the bathroom to get ready. It had been his desire to lead a normal life as much as it was possible for his species. That’s why he had studied and went to work like any other human being. Although due to his background he didn’t have to do anything. His father had seen to it that the woman he loved and the two sons he had given her would want for nothing in life. He had sent her a rich man to marry, who would bequeath her his entire fortune after his death. However, the marriage was short-lived as his father could not bear to see his love in the arms of another man.
After the death of his mother, managing the family wealth lay in the hands of his half-brother Yven, who had been the result of the short marriage.
In the emergency room all hell broke loose. A serious road accident had claimed five deaths and Dr. Henry Rodman had struggled for two hours to save the lives of the three seriously injured. When Morris entered, relief reflected in the face of his colleague, who tried with bloodstained hands to stabilize a patient who had a steel rod rammed into the abdomen. But the shaft slipped out and in its place was a large gaping hole that now spurted blood. Dr. Rodman reached into the opened abdominal cavity and pressed the artery closed by hand.
“Patient with polytrauma,” he explained to Morris, who guessed the severity of the injuries at a glance and classified the chances of survival as very low. The monitor displayed the baseline heart rate that gave an urgent and monotonous tone.
“Cardiac arrest, doctor.”
But the surgeon did not respond.
“Dr. Rodman, no more vital functions,” said the nurse now urgently. “The patient is dead!”
“Adrenaline.”
The nurse reluctantly prepped the adrenaline syringe.
Henry Rodman pulled it out of her grasp and drove the entire dose into the vein. Then he reached for the nurse’s hand and placed it on the open artery. “Come on! Just press!” He worked the sternum of the patient, but the line of the ECG remained merciless and even the continuous tone signaled the futility of the resuscitation.
Morris put his hand on the doctor’s arm. “She’s not there anymore, Henry. Let her go.”
Slowly, the physician seemed to respond. He was completely overworked and Morris led him out. “Go home and get some rest, I’ll take over now.”
His colleague looked at him with gratitude and trudged down the hall with his head hanging, to his well-deserved time off.
While looking at the big clock above her head and writing down the exact time of death, a movement caught her eye. “Dr.?” Silently she pointed to the ECG recording. “We have activity.” She shook her head in disbelief. “Incredible. I thought she is …”
“Columbus also thought that he had landed in India.”
A clear, slight twitch could be seen on the device that could also just be a last gasp, a deceptive sign of uncoordinated cardiac work. The nurse reached for the defibrillator and gave him the electrodes. Morris, who at the same time felt for the patient’s pulse, looked at her furiously. “The patient has a PEA. Have you heard of it?! What are you doing with the defibrillator?”
The nurse helplessly checked for a pulse and could not find it, just like Morris, who meanwhile administered thoracic compressions. “P stands for pulseless. Would you therefore please start respiration.”
Morris called for a colleague to take care of the damaged artery while he continued massaging the heart and resumed the work initiated by Dr. Rodman, although he wished that the young woman would have completed her journey today.
The nurse pumped oxygen at regular intervals into the lungs and nodded to him encouragingly as the heart line became regular and stronger under his hands. “You have golden hands, Doc,” she said and wiped the sweat from his brow.
The eyes of the patient opened for a brief moment and her pupils were dilated, staring past him, seeing something from another world that was incomprehensible to her human mind. As soon as she awoke, all would be forgotten and then the race was on. Morris knew the game; she would either soon need psychiatric treatment or turn into a black soul. The last possibility was that she was strong enough and trusted in God, but not many did that…
Copyright by Lilly M. Love
www.lillymlove.com
available on Amazon, Paperback http://amzn.to/YrNSWp
or E-book http://amzn.to/WM1TPB
~ by lillymlove on February 2, 2013.
Posted in Books, Prince of the Dark
Tags: chapter I, chapter II, Demon of Dreams, doctor, Dreams, Excerpt, Lilly M. Love, prince of the dark, saga, Vol. II
2 Responses to “Excerpt from Prince of the Dark Vol II. of the Demons of Dreams Saga, Chapter I, Chapter II, Chapter III”
Lilly, I tagged you on my blog. Here’s my link so you can post mine.
http://dreamweavernovels.blogspot.com/
Let me know when you post. Thanks for playing. Su
Su Williams said this on February 3, 2013 at 6:51 am | Reply
Thank you so much, Su, I have some more blogs to add, but I don´t know where I can do it on my page, so it makes sense and don´t disappear. Talk to you later….will figure someth. out. 🙂
lillymlove said this on February 3, 2013 at 12:39 pm | Reply
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Rising in the Polls, Sanders Takes Jabs From Trump, Warren
January 14, 2020 | by James G. Dalton
Bernie Sanders found himself on the receiving end of attacks from both President Donald Trump and Elizabeth Warren on Sunday, a reflection of his rising status in the Democratic presidential race and perceived momentum just three weeks out from the Iowa caucuses.
In a tweet, Trump declared, “Wow! Crazy Bernie Sanders is surging in the polls, looking very good against his opponents in the Do Nothing Party. So what does this all mean? Stay tuned!” Sanders responded in the same medium: “It means you’re going to lose.”
But it was Warren — who has generally avoided criticizing her fellow progressive over the course of the Democratic primary — who offered the sharpest criticism of the Vermont senator, saying she was “disappointed” by a report that the Sanders’ campaign is instructing its volunteers to speak negatively about her to win over undecided voters and suggesting he is too divisive to beat Trump.
“We cannot nominate someone who takes big chunks of the Democratic coalition for granted. We need someone who will bring our party together,” she told reporters after a campaign event in Iowa.
“We need someone who will excite every part of the Democratic Party, someone who will be there, someone that every Democrat can believe in.”
Warren also warned against repeating “the factionalism of 2016,” during which the unexpected strength of Sanders’ challenge to Hillary Clinton’s candidacy produced a drawn-out and oftentimes nasty Democratic primary fight that some Democrats say contributed to Trump’s win.
Her comments come in response to a report in Politico revealing the Sanders campaign canvassing script suggests volunteers tell voters leaning towards Warren that “people who support her are highly-educated, more affluent people who are going to show up and vote Democratic no matter what” and that the senator is “bringing no new bases into the Democratic Party.”
Both Sanders and Warren, who are vying for the progressive lane in the primary and largely agree on many of the biggest issues in the race, have up until now publicly avoided attacking one another and in fact have been complimentary of each other.
In contrast, Sanders has in recent weeks been going aggressively after opponent Joe Biden for his support for the Iraq War and his trade policy.
While Biden has largely stayed mum on Sanders’ attacks in recent days, Warren’s broadside sets the potential for a debate-stage clash in which he’ll likely be attacked by multiple opponents. The Vermont senator has been rising in a handful of state and national polls over the past month and is seen to have momentum heading into the final three weeks before the first nominating contest takes place in Iowa.
via newsmax
FOFY286 on Why Adam Schiff Is Too Biased To Manage Trump’s Impeachment Trial
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Tag Archives: amorite dynasty
Babylonian King Hammurabi and Law Code of Marduk the Sumerian Anunnaki god of Babylon
“Whereas Sargon seems to have relied upon his power and his terror tactics to keep people under control, Hammurabi presents himself almost like a modern politician in that he wants to be loved; he wants the people to like him; he’s going to set up laws that will protect them, not laws that will terrify them or force them into submission.”
~ Amanda Podany, Cali State Polytech, Pomona, CA
[This mardukite.com blog is officially extracted from Liber-51/52, available as the standalone title SUMERIAN RELIGION II, in the Liber-50/51/52 anthology MESOPOTAMIAN RELIGION or the new exclusive economical Mardukite Year-2 anthology GATES OF THE NECRONOMICON edited by Joshua Free.]
In the post-Sumerian “Mardukite” era of MESOPOTAMIA, the traditions and systems of the Anunnaki were sealed under MARDUK, heir of ENKI. During the shift to the Age of Aries – the sign of MARDUK, represented by the Ram – religion, spirituality and the global reality experience became fueled by ‘divine politics’.
The famous ‘creation stories’ and ‘mystical definitions’ (that serve as the basis for future traditions and ‘societal reality systems’) were forged onto tablets of propaganda supporting the ‘Babylonian‘ paradigm by the priestscribes of (‘led by’ or ‘dedicated to’) NABU, heir of MARDUK. Figures that appear central to the infrastructure of MARDUKITE BABYLONIAN systems are the younger generations of Anunnaki.
The BABYLONIAN tradition is a direct evolution of the earlier Sumerian legacy – it is the progression of a particular Anunnaki family in MESOPOTAMIA and not simply the assimilation or recreation bring applied to a similar pantheon elsewhere (as we see in cases of later developed ‘classical mythoi’, which simply regurgitate to us the ancient themes with new names. After the vision put forth by Sargon, King Hammurabi (c. 1790 B.C. by the short chronology) is the next most famous and contributory ruler toward a Mardukite Babylon in MESOPOTAMIA.
In homage of MARDUK‘s own legacy put forth in the ENUMA ELIS (‘Epic of Creation‘), King Hammurabi reconstructed the ziggurat temple-shrine earth-home of the Anunnaki god MARDUK, the Esagila – built in even more ancient times to establish a Mardukite ‘World Order’ prematurely during MESOPOTAMIA‘s evolution – an effort brought down as an archetype of the ‘Tower of Babel’ ziggurat by the Enlilite Sumerians.
Related Blog: Enuma Elis: Secrets of Ancient Power and Magic of Marduk the Anunnaki god of Babylon
The region of Babylon experienced human occupation since at least the Third Millennium B.C. (since at least the period of Sargon of Akkad c. 23rd century B.C.). That being said, the independent BABYLONIAN city-state of the “Mardukite” legacy we know today is launched primarily through the efforts of the Amorite Dynasty; specifically Hammurabi, who goes on to replace the former Enlilite Sumerian tradition with a complete MARDUKITE BABYLONIAN re-write.
Sumerian language is denationalized and scribes record all literature in the “new” Akkadian-Old Babylonian that accounts for the majority of pre-Assyrian cuneiform tablets found and translated today. The BABYLONIAN cuneiform tablet literary revolution by the priest-scribes of NABU made way for the means to establish a firmly rooted evolution of the Anunnaki tradition emphasizing MARDUK as the supreme ‘King of the Gods‘ and completely replacing the previously accepted SUMERIAN paradigm.
King Hammurabi is considered the greatest empire engineer since Sargon of Akkad. Efforts conducted over the forty-three year period of his reign allowed a centralized ‘world government’ of BABYLON to form that not only served the people on an emotional, cultural and religio-spiritual level, but also reaching energetic and monetary heights in global wealth, power and influence.
Ruling in honor of MARDUK allowed King Hammurabi to bring BABYLON to fruition with cultural and spiritual heights not visited again for at least one-thousand years when over a millennium later, the Neo-Babylonian era of Nebuchadnezzar II. Of the many conventions introduced to human civilization from BABYLON, the Hammurabic legal system is one of the most significant to note – made popular in consciousness as the “eye for an eye” methodology known as the CODE OF HAMMURABI. Although tyrannical and draconian penalties are the most frequently cited examples of the ‘Code’, the details of 282 laws established the citizen rights, property rights, social rights and even feminine equality rights in addition to the creation of a “class” system.
The CODE OF HAMMURABI, by its own account, does not originate from the mind of King Hammurabi himself, who considered himself merely a catalyst for the reign and power of something ‘greater’ than himself: that of the patron deity, MARDUK. The ‘Code’ or Law of Hammurabi, is in fact what the modern MARDUKITE CHAMBERLAINS movement dubbed the “Book of the Law of Marduk.”
Filed under akkadian, ancient esoterica, ancient near east, assyrian, babylonian, excerpt, magick & mysticism, mardukite, mesopotamian, modern occultism, new babylon, new release, plans & proposals, research development, sumerian, truth seeker press, youtube
Tagged as akkad, akkadian language, akkadian tablets, akkadians, amorite babylonians, amorite dynasty, ancient mesopotamia, ancient tablets, anunaki, anunaki gods, anunnaki, anunnaki gods, assyrian language, assyrian tablets, babylon, babylonian kings, babylonian tablets, book of marduk by nabu, code of hammurabi, cuneiform tablets, cuneiform writing, enki, enki god, enlilite sumerians, enuma elis, gates of the necronomicon, hammurabi, joshua free, king hammurabi, king nebuchadnezzar, king sargon, law of marduk, marduk, marduk god, mardukite, mardukite blog, mardukite chamberlains, mardukite com, mesopotamia, mesopotamian mysteries, mesopotamian necronomicon, mesopotamian pantheon, mesopotamian religion, nabu, necronomicon anunnaki bible, neo-babylonian era, sargon of akkad, sargon the great, sumer, sumerian anunnaki, sumerian necronomicon, sumerian pantheon, sumerian religion, sumerian religion 2, sumerian tablets, sumerian wisdom, sumerians, the anunnaki
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Tag Archives: lovecraftian
CROSSING TO THE ABYSS — Secrets of the Simon Necronomicon Revealed by Mardukite Nabu Joshua Free
“Shrouded in doom and gloom, contrasted against the “Cthulhu Mythos” envisioned by H.P. Lovecraft, who very well may have developed the title — Necronomicon — for his own saga and literary cycle, the book presented by editor Simon is anything but a fabrication of fantasy, but is instead an allusion to a very real, though fragmented, “Mardukite” Babylonian Anunnaki Tradition, a system that once dominated the prehistoric and ancient world before the rise of the Greeks, Romans and even Egyptians!“
Originally published by the Mardukite Truth Seeker Press for the Year-4 literary cycle in February 2012 — and appearing as both “Stargate to the Abyss” and “Necronomicon For Beginners” — Joshua Free’s underground occult classic Liber-555 celebrates its Fifth Anniversary in the new eco-edition of CROSSING TO THE ABYSS: UNVEILING THE SECRETS OF THE SIMON NECRONOMICON!
“Given the extent of my involvement in matters concerning the Necronomicon for twenty years, it should not be surprising to find that I am now being called out from the dark corners I am usually want to residing in regarding the topic of the “Simonian” recension of the Necronomicon that has earned so much notoriety and publicity since its arrival in the underground during the late 1970’s,” explains Joshua Free in the introduction to Liber-555.
“The Simon Necronomicon is a delicate topic for me, and so it has been a long time coming for me to actually give attention to answering others towards its details. In the past, I have directly avoided such a feat, preferring the work to stand on its own to those culled into its mystique, hardly able to be overshadowed by the efforts of other writers and occultists that have made a system to their own preferences, lending a healthy hand to supporting the allusions made in the fiction writing of H.P. Lovecraft and the later inspired Cthulhu Mythos – connected to our own efforts purely for the fact that the title Necronomicon is shared and perhaps even derived from the Lovecraftian sources.“
Since being released in 1977 — the same year that the world saw the arrival of “Star Wars”, the “Shannara” series of Terry Brooks, “Close Encounters of the Third Kind”, the “12th Planet” debut by Zecharia Sitchin and many other consciousness paradigm-shifts — the Necronomicon by Simon has changed the shape of the modern “New Age” movement and human understanding, introducing over a million people of the new generations to the reality of the Anunnaki traditions born from ancient Sumerians, Babylonians, Akkadians, Assyrians and Chaldeans of Mesopotamia. Many of these mysteries are also explored on our alternate site: NECROGATE.COM
Mardukite founder Joshua Free continues: “What has drawn in the connection between Simon’s Necronomicon and our own work is the underlying resonance of the original ‘Mardukite Anunnaki Tradition’ from Babylon that appears in “his” grimoire far stronger than any Lovecraftian flavors or the Cthulhu Mythos – and it is for this reason that it has been so often paralleled with the modern “Mardukite” efforts.“
Someone approaching the Simon Necronomicon without any previous occult knowledge may be confused as to its ‘magickal’ and ‘esoteric’ suggestions for ritual and ceremony, and yet the ‘heart’ of the material will still seep in and formulate some kind of change in the reader – especially if the lack of previous ‘occult’ knowledge is being coupled with no background in ancient ‘Middle Eastern’ or otherwise ‘Mesopotamian’ cultures and mythologies. If such is the case, the book will be naturally regarded as a highly cryptic or otherwise ‘incoherent’ blend of names and correspondences that are without basis.
“My own personal interests in the Simon Necronomicon have always – for twenty years now personally – remained fixed on its connection to ancient “Mardukite” Anunnaki-oriented systems. Similarly, the book has actually served as a ‘portal’ or ‘gateway’ in and of itself to many of its readers into this ‘lost’ and ‘forbidding’ pursuit of intellectual academia and occult esoterica; people who would otherwise have had no real familiarity with ‘Babylonian Gates’ and ‘Anunnaki Gods’ later reminisce that the Simon Necronomicon was their own introduction to topics.”
The modern “Mardukite” research organization has spent nearly half a decade exploring the mysteries of Mesopotamia, the Anunnaki and related subjects. After having completed the entire NECRONOMICON ANUNNAKI LEGACY with the Mardukite Chamberlains, prolific writer, editor and founder of the “Mardukites,” JOSHUA FREE, ends his years of silence concerning the Simon Necronomicon by finally providing his expert commentary on the classic text in Liber 555, “Crossing to the Abyss: The Mardukite Guide to the Simon Necronomicon.”
Filed under ancient esoterica, excerpt, magick & mysticism, mardukite, mardukite publishing group, modern occultism, new babylon, new release, research development, truth seeker press
Tagged as 12th planet, akkadians, ancient mesopotamia, anunnaki, anunnaki gods, anunnaki legacy, anunnaki pantheon, babylonian necronomicon, babylonians, chaldeans, crossing to the abyss, crossings, cthulhu cult, cthulhu mythos, hp lovecraft, joshua free, liber 555, lovecraftian, mardukite, mardukite chamberlains, mardukite necrogate, mardukite truth seeker press, mesopotamia, mesopotamian, mesopotamian magic, mesopotamian mythology, mesopotamian necronomicon, mesopotamian religion, middle east, modern occultism, necrogate, necrogate blog, necronomicon, necronomicon anunnaki bible, necronomicon anunnaki legacy, necronomicon for beginners, necronomicon grimoire, necronomicon history, necronomicon magick, necronomicon order, necronomicon school, necronomicon spellbook, necronomicon workbook, new age, shannara, simon necronomicon, simonomicon, star wars, stargate, stargate to the abyss, sumerians, terry brooks, zecharia sitchin
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“Hoda Kotb and Jenna Bush Hager welcome author Margaret Renkl, who discusses the story behind her book and answers questions from readers at home.”
~An interview with Today
“We’re here with Margaret Renkl. She wrote one of the most beautiful books I’ve ever read. It is our December pick, and I loved it.”
~A longer interview with the Jenna Bush Hager for the Today show’s book club
“Late Migrations is a loving ode to family, the Alabama landscape that cradled them, and the natural world.”
~An interview with Alabama Public Television
“I love the book very much. I suppose that doesn’t sound very objective, but boy, it’s a wonderful book.”
~An interview with Margaret Roach for Robin Hood Radio
“For members of the Nashville literary community, Margaret Renkl is something of a hometown hero.”
~an interview with BookPage
“Late Migrations reminds us all of the timelessness of life cycles and that while our gardens and gardening impulses may not be enough to repair everything, they are a very powerful and meaningful something in the right direction.”
~an interview with Cultivating Place for North State Public Radio
“Margaret grew up in Alabama, and her book alternates between observations of the natural world and stories from her life in the South. We talk about her writing for The New York Times, the importance of strong women in her family, the resurgence of the local bookstore, and how she learned to live with loss.”
~the Reckon interview for Al.com
Author Margaret Renkl talks to host Mary Laura Philpott about Late Migrations on Nashville Public Television’s A Word on Words
“In Late Migrations Renkl’s lush essays invite readers to come with her to the American South, to her past, to nature she observes with lyricism, and to the challenges of life passages.”
~an interview with The Adroit Journal
“In this poignant and powerful episode, Margaret talks to WPLN’s Emily Siner about documenting complicated families, grieving with animals, and writing a book in 15 minutes.”
~an interview with Nashville Public Radio
“You’ve talked about how your brother did those interviews with your grandmother, but your brother also did the art for the book, and it’s fabulous. In using your grandmother’s exact words in the book reminds me of how the art is constructed. By using a collage method, you’re taking the words of someone else and weaving them into the work itself.”
~an interview with Stephen Usery for WYPL’s Book Talk
“The ordinary becomes filled with wonderment and loss, and we discover that the shadow side of love is part of the life we all share.”
~an interview with Sally Wizik Wills for the American Booksellers Association
“This is memoir by way of adjacencies. This is the story of a tight-knit clan and their red-dirt roads, their abiding dogs, their rainstorms, their birds, their living in-between the dying. This is the story of grief accelerated by beauty and beauty made richer by grief. This is scout bees, bluebirds, ragged foxes, fur-lined bunny nests, and yes, of course, those migrating butterflies. It is the story of a girl, now a woman, who watches it all through the window of her life.”
~an interview with Beth Kephart in The Rumpus
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Updating your Python Facebook Application for the October 1st OAuth 2.0 Migration 8 years, 3 months ago by Martey Dodoo
Earlier this year, Facebook announced plans to have its application developers transition to OAuth 2.0. It spent the last few months updating its PHP and JavaScript SDKs.
Unfortunately, their Python SDK was not so lucky. In July, they quietly announced that the Python SDK would be unsupported by Facebook in the future.1 If you are using the formerly-official Python SDK for Facebook, you need to figure out how to update your applications on your own.
If you built your own OAuth authentication workflow, you can easily modify it using Facebook's authentication documentation (see the "Client-side Flow" section). However, many Python developers constructed their application to work with the JavaScript SDK (because that's what Facebook suggested). Since the OAuth 2.0-compatible JavaScript SDK's source will not be available until December2, it is not clear what in the Python SDK needs to be updated.
Since I have a number of web applications that need to be updated, I decided to take a crack at this last week. I quickly deduced that the JavaScript SDK used a different, encrypted cookie format. This meant that the get_user_from_cookie function in the Python SDK would need to be updated.
Previously, the JavaScript SDK created a cookie with a prefix of fbs_. The Facebook user ID and access_token were stored in a plain-text dict. With OAuth 2.0, Facebook is now using a cookie prefix of fbsr_ and encrypting its cookie data. Using the source of the PHP SDK and relying on my experience authenticating with application-specific tokens, I wrote code to decrypt the information in the cookie, send it to Facebook's OAuth endpoint, and return the access_token in the same format (plain-text dict) as the previous Python SDK, so that I was not forced to rewrite the rest of my application.
Unfortunately, the code is too long to post here, but you can view it at my fork of the Python SDK the pythonforfacebook fork of the SDK on Github. I am not certain that it is bug-free, but it seems to work fine on MP3 Gift.
This change came without any warning, after several months of silence. Facebook also deleted the bugtracker on the Python SDK's Github repository, deleting a significant amount of the conversation about the best fixes for errors found in the original code they produced. As you can imagine, this fragmented the community. There are several forks of Facebook's code on Github, but there is no longer any conversation about bugfixing or features, let alone best practices.
While one of the themes of Facebook's Developer Love initiative is "communication", this significant change was virtually hidden. There was no post on the developer blog announcing the change. The Python SDK's source has still not been updated to warn new developers that it is unsupported. I suspect that the only reason that the bug was updated was to provide sufficient rationale for closing it. ↩
Like Android, Facebook's JavaScript SDK uses the Apache License 2.0, which does not require releasing newer versions of software under the same license. ↩
Facebook Programming Python
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Posted on December 23, 2018 December 23, 2018 by Martin Rose
Unable to leave well alone, I found myself compiling a second alphabet this winter. It is much as before, and entirely inconsequential. Anyway, for those who do not entertain Twitter, here is the whole caboodle. Happy Christmas.
A is for Amicable numbers, pairs of numbers magically related, each the sum of the other’s divisors. The first pair, 220/284 was used as a love charm. Arab mathematicians once recommended carving them on two fruits as a mutual aphrodisiac. The next pair is 17296/14416. Bananas?
B is for Balcony: Anthony Wood says, “Archbishop Spalato was the first that made a balconney in England, being on the backside of the Savoy,” ca. 1620. Stress was on 2nd syllable, “balcOny,” till 20th century. Jack Aubrey let none on his quarter-deck who said “bAlcony.” HMS Shibboleth.
C is for Cento, a poem made up of lines or passages filched from other poets, originally Virgil. A favourite non-Virgilian cento: Gather ye rosebuds while ye may / And let who will be clever. / God moves in a mysterious way, / But I go on for ever.”
D is for Draisin, a pedal-less, tyre-less, brake-less bicycle invented by Baron Karl von Draisin and shown at the Congress of Vienna: you paddled it with your feet. Tricky on hills. Draisin has bizarrely become a modern brand of recumbent bike. With pedals and tyres – and brakes.
E is for St Expeditus, a 3rd century Roman soldier called Elpidius, re-launched in 1781 when a parcel of bones arrived at a French concent marked “Expédit,” which the nuns took for his name. Patron of haste and quickly settled lawsuits, he is popular in Réunion and New Orléans.
F is for Fistula Club, an institution that proliferated in France when Louis XIV was diagnosed with an anal fistula, and it became a sought-after fashion accessory. 1686 was known as “L’année de la Fistule,” after pioneering remedial surgery on the royal bottom by Dr Felix.
G is for Gamp, from Dickens’s Mr Gamp who always carried a large, unwieldy one: a better name for an English ‘umbrella’ with its absurd suggestion of shade. Ben Jonson describes an umbrella “made of the wing of an Indian butterfly,” which wouldn’t have cut the mustard in London.
H is for Hood-wink, a classy blindfold. “The cheetahs are kept hood winked on a cord and when they get near enough to the deer the hood is taken off and they are slipped at the game,” wrote Lytton Strachey’s grandfather. Freemasons are deliciously hoodwinked with steam-punk goggles for their initiation.
I is for Intinction, or liturgical dunking – dipping the communion bread in the consecrated wine before swallowing. The Orthodox tip all the bread into the chalice with the wine and serve with a silver teaspoon. Intinction is banned in Canada, which seems prim.
J is for Jingling Johnnie, the Ottoman staff festooned with bells, brassware and horses’ tails once twirled in military bands by black jinglers in leopard skins. Dropped by the British army in 1837, it remained a favourite of the French Foreign Legion, where perhaps it jingles still.
K is for Kenspeckle, conspicuous or recognisable, from the Scots – Burns thought his “phiz sae kenspeckle that even the very joiner’s apprentice” knew it. A mixed blessing – and in this age of facial recognition software Google makes kenspeckles of us all.
L is for Lewis Hole, by which a heavy ledger stone is lifted: the Lewis, a Roman gadget, is popped in and its arms spread under tension. Beneath lies what the Dutch call a ‘rijke stinker,’ a rich stinker who bought a grave in the chancel to the olfactory discomfort of worshippers.
M is for Mummy, put to odd uses. In 19th century Egypt, according to Mark Twain, mummies were used for stoking locomotives. Oddly, dried salt fish met the same need in Azerbaijan ca. 1920, and occasionally popped out of the funnel, charred but whole, to be chased by starving Azeris.
N is for the Nun Bun, a cinnamon bun found in Tennessee with an uncanny resemblance to Mother Teresa of Calcutta and kept, shellacked, in a bar in Nashville where it was known irreverently as “the Immaculate Confection.” It was kidnapped on Christmas day 2005 and never returned.
O is for Otter, a fragant defæcator: at Heligan a sign records otters’ occasional “jasmine-scented spraints,” one of many glorious synonyms, from the Questing Beast’s fewmets, the hare’s croteys, and the bear’s lesses to the badger’s feances. Never confuse croteys with croutons.
P is for Pottle, a double quart measure. “A pint is the least measure that hath a peculiar name with us, two of them make a quart, two quarts a pottle, two pottles a gallon.” (Gouldman’s Copious Dictionary, 1674). Bring back the pottle as a consolation for the idiocy of Brexit!
Q is for Quizzing-glass, a magnifier held close to the eye to scrutinize, and to express condescending disdain; distinguished by its handle from the monocle screwed into a vacant fish-eyed socket à la Rees-Mogg, who simply looks like the oyster-eyed Dr Prunesquallor.
R is for Recumbentibus, cod-Latin for the knock-out blow that leaves you involuntarily recumbent. Not to be confused with circumbendibus, the roundabout, scenic route to anywhere. Suspicious coinages: they all sound a bit mumpsimus to me.
S is for Scioptic Ball, a spherical rotating bearing of lignum vitæ set into a socket in a window frame to acrry sunlight inwards, as a small camera obscura, or used as a universal joint into which telescopes and other instruments could be screwed. Every home should have one.
T is for Tattoo, vulgar ornament of today’s epidermis. Not, though, the monopoly of models or footballers: King Edward VII “had quite a few tattoos, many of them done by Sutherland Macdonald, a legendary tattoo artist with a shop above the Turkish baths at 76 Jermyn Street.”
U is for Ullage, the semi-magical loss of beer from a barrel(speciality of my scout at Magdalen in the 70s); leading me on to ‘Bezzle,’ J K Galbraith’s wonderful term for the amount of money likewise syphoned off in transit or (as they say) in transaction.
V is for the Vein of Love, supposedly connecting the fourth finger of the left hand directly with the heart, and accounting for the wearing of the wedding ring. First mentioned by Dr Swinburne in a 1868 law book, citing ancient Egyptian wisdom – which miraculously pre-dated William Harvey.
W is for Whiffler-Waffler, a minor but important functionary who headed a procession waggling and tossing a staff or sword in intricate patterns to clear the way, like a drum-major, or the flag-bearer of a Sienese contrada. Not much call for whiffler-wafflers these days, sadly.
X is for Xenophage, an eater of strange things like Dr William Buckland, Dean of Westminster and founder of the Acclimatisation Society (to tap new and unlikely food sources), who enjoyed mouse-on-toast, and gobbled down the mummified heart of Louis XIV, at dinner with its owner, Lord Harcourt.
Y is for Yellowcake, the mix of uranium oxides which George W Bush mendaciously alleged Saddam Hussein to be importing from Niger for making nuclear bombs: a manufactured ‘cakus belli,’ and about as honest as saying that this splendid chocolate cake contains uranium oxide.
Z is for Zalmusa, an enormous fish with 70 heads and 70 tails, said like a certain turtle to support the world on his back. On the night the Prophet Muhammad was born, Zalmusa shook so uncontrollably with joy, convulsing the oceans, that the world nearly fell over.
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Considering Carbon Fiber for CRT
CARBON FIBER: ISTOCKPHOTO.COM/ALLANSWART
Perhaps the buzziest engineering material in the always-evolving ultralightweight manual wheelchair space is carbon fiber. Very lightweight, very strong and very attractive to look at, carbon fiber has often been associated with racing vehicles, where speed, light weight and sleek looks go hand in hand.
In complex rehab, where light weight can translate into such significant benefits as easier transfers and transportation, carbon fiber is being used not just for ultralight chair frames, but also in components, such as backrests.
Carbon Fiber Composites
Todd Hargroder of Accessible Designs Inc. (now part of Stealth Products) has worked with carbon fiber for years in wheelchair applications and is a long-time ultralightweight chair user.
“A buddy of mine was building a dragster, and he had made some panels out of carbon fiber,” Hargroder said. “That was my first exposure to it. I saw how pretty and how cool it was, and how lightweight it was. I made a backrest out of it, and just used the mounting hardware off of my old backrest that I had.
“The shell was great, but the mounting hardware was quite ugly, so my next step was to design mounting hardware. After putting the two together and going to a show, that pretty much launched a product line.”
As for working with it, Hargroder said, “Carbon fiber is a composite. It’s a flexible material until it’s mixed with resins or other materials, and it’s all about the mixture. You can make it flexible and bendable, or you can make it as stiff as can be. It’s a recipe that you have to work with depending on your application. It can be flat, it can be round. It all depends on how it’s molded and how it’s used. It can certainly be as strong [as aluminum or titanium] depending on how it’s laid up, how it’s used, how it’s engineered.”
He compared working with carbon fiber and finding the optimal blends to cooking. “It’s all about the recipe, how much of this, how much of that, and then how it’s cooked, the temperatures,” he said. “There’s certainly an art to composite manufacturing.”
Wheelchair Advantages
Among the traits that Hargroder appreciates is carbon fiber’s literal flexibility.
“The great thing about carbon fiber is it is a composite, so you can have it flexible, or you can have it stiff,” he explained. “A backrest made out of aluminum is just made of aluminum. Aluminum is a dead, hard material, and it feels like that. A composite carbon fiber backrest will have some flexibility. We’ve designed flexibility into our backrest so it does absorb vibration, it does take away shock load, it moves with the body much better than a dead, metal back support.”
Hargroder also likes being able to adjust a carbon fiber “recipe” to attain the characteristics he wants.
“With the makeup of the composite back, you can add more material, you can add more layers of carbon, you can add different types of resin to make it stronger or more flexible — whatever your goal is, whatever you’re trying to achieve,” he said.
Still, while Hargroder has achieved much success from carbon fiber designs, he acknowledges the usefulness of different materials in complex rehab situations.
“Most of our mounting hardware is made of aluminum,” he pointed out. “We’ve done some composite mounting, but the majority of our mounting is made of aluminum.
“Aluminum is easier to work with, because you can just put it on a machine and mill it out. Carbon fiber certainly takes a lot more involvement. It all depends on your application. Some things are better made out of aluminum, and some things are better made out of carbon.”
Ask a Clinician: How Design Impacts Ultralightweight Propulsion
Permobil Launches Next-Generation SmartDrive Controls
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I Can Push Myself!
Motion Composites’ Veloce Wins Red Dot Award
TiLite Pilot
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The Minor Peewee’s Have Done It Again…
This time, they were victorious over the border at The Cup North American Championship. This is the 4th championship that the team has won this season, with winning all the tournaments they have entered. They were successful previously at The Toronto Marlies Earlybird, The Shanahan International, Silverstick, and now The Cup North American Championship. This tournament featured all the top teams from Canada and the United States, and the boys still managed to prove themselves again coming out on top with the victory.
The team showed immense selflessness on the ice this tournament. Head Coach Chris Stevenson adds that “every player played for the logo on the front. It didn’t matter who scored, they all supported each other and cared about the team’s success first and foremost. The special thing about this team is they realize a shot block or a great back check are just as important as a big save or scoring a goal.”
However, this tournament was not without its challenges. The team had to fight through tough competition and even found themselves trailing behind 4-2 late in the second period while playing in the quarter-finals against hometown rivals, the Mississauga Reps. “The team never quit and tied the game late in the 3rd and followed that up by scoring the game winning goal the very next shift” Stevenson adds.
The Minor Peewee’s are currently sitting in 1st place in the GTHL standings with an overall record of 49-1-2. It has been an incredibly special season for the Minor Peewee’s and are now planning to continue strong in the second half of the season and prepare for playoffs coming up. Coach Stevenson adds that they are currently trying to win the Kraft Cup (1st place in the regular season) and that “as a coaching staff we couldn’t be prouder of this group of young men, they earn everything they get and we hope their adversity and determination continues as we come to the final stretch run of the season”.
The Mississauga Senators organization would like to congratulate the Minor Peewee’s on all their #SENSational achievements this season. Go Sens Go!
Tournament Scores
Mississauga Senators vs. Valley Jr. Warriors 9-0
Mississauga Senators vs. Brantford 99ers 4-1
Mississauga Senators vs. North Jersey Avalanche 9-0
Mississauga Senators vs. Quinte Red Devils 5-0
Mississauga Senators vs. Mississauga Reps 6-4
Mississauga Senators vs. Anaheim Jr. Ducks 4-2
Mississauga Senators vs. Toronto Jr. Canadiens 4-1
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Wedding Places in Abilene
Hidden Gems of Texas
Alicia Selin
Insider VIP
The Rolling Stones Postpone North American Tour While Mick Jagger Receives ‘Medical Treatment’
Caitlyn Hitt
The Rolling Stones have postponed their North American tour.
The group announced the news early Saturday morning, revealing that the upcoming dates of their No Filter Tour will be rescheduled while Mick Jagger undergoes "medical treatment." The tour was set to kick off in Miami, Florida, on April 20.
"Mick Jagger has been advised by doctors that he cannot go on tour at this time as he needs medical treatment. The doctors have advised Mick that he is expected to make a complete recovery so that he can get back on stage as soon as possible," a statement obtained by ET Online read.
A rep for the Rolling Stones declined to comment further on the condition for which Jagger is being treated. The 75-year-old musician apologized to fans on Twitter, saying that he hates "letting you down like this."
"I'm so sorry to all our fans in America & Canada with tickets. I really hate letting you down like this," he tweeted. "I'm devastated for having to postpone the tour but I will be working very hard to be back on stage as soon as I can. Once again, huge apologies to everyone."
All 17 dates on the No Filter Tour scheduled in North America have been postponed. Fans have been advised to hold onto their tickets, as they'll be valid for all rescheduled dates.
Music Comebacks We're Waiting For
Source: The Rolling Stones Postpone North American Tour While Mick Jagger Receives ‘Medical Treatment’
Filed Under: Mick Jagger, Rolling Stones
Texas Gun and Knife Show
Abilene Business Listings
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After a $20 million funding round fell through, augmented reality headset maker Meta Company has been forced to furlough (or place on temporary leave of absence) approximately 65% of its workforce for 30 days.
In another move that pushes Meta 2 toward becoming a legitimate workplace tool, Meta Company has partnered with Dassault Systèmes to bring augmented reality support to the latter's Solidworks 3D CAD software.
Using the CES tech conference in Las Vegas as the launch pad, Dell has announced that it's partnering with Meta Company to offer its augmented reality headsets to business customers.
With today's augmented reality experiences, we can see and hear virtual content, but Ultrahaptics wants you to be able to feel those experiences, too.
What do you get a co-worker for Christmas, Hannukah, or Kwanzaa when he or she already has a Meta 2 headset?
Now that it has buried the legal hatchet with Meta Company, augmented reality startup Dreamworld has announced plans to open up pre-orders for its Dream Glass AR headset.
While Meta Company has agreed to a settlement in its lawsuit against a former employee and his company, they find the tables have now turned on them in the form of patent infringement allegations from another entity.
Just a year after facing trade secret theft allegations from his former employer, ex-Meta Company employee Kevin Zhong and his new company are ready to ship the product that triggered the lawsuit.
Augmented reality headset maker Meta Company unveiled Meta Viewer, its first software application, during its keynote at the Augmented World Expo in Santa Clara on Wednesday.
Following up on a preview of the deal we reported during last week's CES, Dell has officially announced the details around its role as the first company to resell the Meta 2 augmented reality headset.
Facing claims of misappropriation of trade secrets and confidential information by Meta Company, DreamWorld, led by Meta's former employee, Zhangyi "Kevin" Zhong, has fired back with a motion to dismiss the lawsuit.
Augmented reality headset and software maker Meta Company announced today board member Joe Mikhail will serve as the company's chief revenue officer.
By Jason Odom
Last June, Meta began shipping their Meta 2 mixed reality headset, to the delight of many. In September, it was announced that shipping had been delayed until the end of the year. Then it appeared that Christmas would bring something magical when Meta sent out an email four days before the big holiday saying that the Meta 2 developers kits were finally shipping. Unfortunately, having a few on order here at Next Realit,y we are still patiently waiting for ours to arrive.
Meta Company filed suit today against a former employee and his startup DreamWorld USA, Inc. for the misappropriation of trade secrets and confidential information.
Meta CEO and founder — and Next Reality 50 member —Meron Gribetz unveiled a new operating environment for augmented reality called Meta Workspace for the audience at the Augmented World Expo (AWE) in Santa Clara, California, today.
The largest and arguably most widely known event of its type, especially in the US, the Sundance Film Festival is an annual celebration of independent film—ones made outside the Hollywood system. This year, a new type of experience appeared at the Sundance Film Festival in an installation called "The Journey to the Center of the Natural Machine." This mixed reality presentation offered the user the newest type of storytelling in a long and important line—continuation of the species kind of im...
Meta's long-awaited Meta 2 development kit finally began shipping in late-December last year, after having been delayed about six months. While very few have received a dev kit at this point, some more information about the headset has just been announced; Depth-sensing technology from pmdtechnologies is included in the dev kit headset.
The Meta 2 developer kit has finally begun shipping! Gary Garcia, the senior director of customer success at Meta, just sent out an email that they are shipping out to the first round of preorder customers. Waves will be building from there, up to far higher manufacturing rates near the end of Q1 of 2017.
News: Meta Delays Shipments of Developer Kits Until the End of the Year—& That's a Good Thing
By Adam Dachis
The future for the Meta 2 augmented reality headset will have to wait. While shipments were supposedly on their way out back in June, Meta revealed today that they need a bit more time to provide the best possible experience—and that's really for the best.
Exclusive: Meta's Ryan Pamplin on the Meta 2 Headset & the Future of Mixed Reality
The future of augmented and mixed reality offers many possibilities, mostly because we're still figuring out everything it can do. While Meta is open to exploration, they've spent a lot of time thinking about what the future of this technology will be.
Microsoft enjoyed a few months in the spotlight after releasing the developer version of the very first mixed reality (MR) headset, but now we're starting to see the competition jump in.
Microsoft's enjoyed being the only mixed reality headset on the block for a little while, but the Meta 2 intends to join the party very soon. According to UploadVR, in a couple of weeks they'll begin shipping alpha versions of their headset with improved hand tracking.
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> Art—Fords>"The Chase Lives On"
"The Chase Lives On"
"Whenever I see a green '67 or '68 Mustang fastback, I immediately, and without thinking, conjure up images of Lt. Frank Bullitt piloting his Mustang down the streets of San Francisco in pursuit of the menacing 1968 Charger. I can't help it. It just happens! From the first time I watched the movie, "Bullitt," I thought to myself ... "That looks like fun. I would love to do that!" ... So I did! Now with the release of Ford's new Bullitt Mustang, the next generation will ask us why is this such a special car? And it's our responsibility to tell them, or better yet, go to San Francisco, rent a new Mustang, and show them why!" MICHAEL IRVINE
Artist Proof with Single Remarque
Artist Proof with Double Remarque
Retouched Gallery Edition Canvas
"The Chase Lives On" — The 2001 & 2008 Bullitt Mustangs Joining the Chase
The release of the newest Bullitt Mustang reflected the continued excitment of a car chase scene from a 40 year old movie that's become generational. It reminds us all, that the "chase lives on!"
This painting is based on a scene from the famous movie. In the movie, you're in the back seat looking at Steve McQueen's character, Frank Bullitt, in profile and the cars parked on either side of the street are just a blur. Michael takes you out of the car, turns you around and has the cars cresting the hill towards you ... and all those parked cars are now viewed from the other side and are in full focus!! Ever present, the assassin's black 1968 Charger is reflected in the front bumpers of the cars as they bear down on their prey.
In San Francisco, Michael and his family, doing the "Bullitt Run":
ABOUT MICHAEL IRVINE'S REPRODUCTIONS All reproductions are individually hand-signed/hand-numbered by artist Michael Irvine • Accompanied by signed/numbered Certificate(s) of Authenticity • Limited Edition Prints and Artist Proofs are embossed with Michael's Studio Seal.
Limited Edition Print 28" x 22" - Limited to 800. (Image size 26" x 16") 10pt satin finish, acid free, museum quality stock. Choice of available print number. Indicate top 2-3 choices below (eg #200/800). Last 3 digits of VIN numbers are popular.
Original Watercolor Painting Contact the Studio.
"I had been doing a lot of research — watching the...
"Chasing History"
“I wanted to create a piece that was a fusion of the...
"BEEP BEEP!"
"It [Bullitt] is definitely my favorite car chase...
"DODGE N' A BULLITT"
"Of all the movies that I've seen that involve a...
"End of the Line"
"This painting was as fun to create as it was...
"New to the Chase"
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Home Cryptocurrency Another Canadian crypto exchange owner vanishes as regulators close in
Another Canadian crypto exchange owner vanishes as regulators close in
In the wake of the QuadrigaCX imbroglio, two more Canadian crypto exchanges are under investigation. Regulators are investigating numerous complaints and it appears that the owner of at least one of the exchanges has disappeared, taking users’ funds with them.
Crypto exchange boss missing
The British Columbia Securities Commission (BCSC) has taken action to protect the customers of two Vancouver-based crypto exchanges, Einstein Exchange and ezBtc.
The websites for both have recently gone dark leaving customers fearing for their digital assets.
According to reports, users of the ezBtc exchange have not been able to access their digital assets for at least two months.
The BCSC’s mandate does not typically extend to crypto exchanges so the move was unexpected. It has been the first public announcement of an exchange investigation by the regulator.
“BCSC’s policy is not to comment on the existence of an investigation, but has determined it is in the public interest to do so in this case,” a spokesperson for the agency said.
“Customer assets are at risk. Anyone who invested through ezBtc should consider consulting a lawyer about their options for retrieving their money.”
Earlier reports indicate that ezBtc has been accused of owing millions of dollars while its founder, David Smillie, could not be reached as his mobile and email services have been deactivated.
Local media outlet The Tyee investigated four lawsuits launched by ezBtc users earlier this year.
Other clients also claimed to be owed thousands of dollars and two of Smillie’s former business associates are also suing him, alleging that he owes them 4,700 Bitcoins – worth more than US$43.7 million [AU$63.3 million] at current prices.
All attempts to locate Smillie have been in vain.
The BCSC added that no crypto-asset trading platforms have been authorized to operate and they could be subject to action if violations occur.
Further investigations into Canadian exchanges (P N G)
Further investigations into Canadian exchanges
In a related press release, the Canadian regulator announced that it was also investigating Einstein Exchange in order to protect its clients.
Last week the BCSC applied to the Supreme Court of British Columbia for an order appointing an interim receiver to preserve and protect any assets on the troubled exchange.
The Commission appointed Grant Thornton Limited, a leading Canadian accounting and business advisory firm, as interim receiver.
A number of complaints had been received and the exchange announced on October 31 that it was planning to shut down within 30 to 60 days due to a lack of profit.
The following day Grant Thornton representatives entered the premises.
Like ezBtc, the owner of the Einstein Exchange, Michael Ongun Gokturk, has seemingly disappeared and is not returning phone calls or text messages.
It has not been revealed whether any assets have been seized but those affected have been advised to contact the advisory firm.
An affidavit posted on Grant Thornton’s website states that Einstein owes its customers approximately $16.3 million in cryptocurrencies and fiat.
Canadian regulators have upped the game against spurious crypto exchanges following the demise of Vancouver-based QuadrigaCX.
Recent estimates claim that roughly 76,000 users have come forward to claim they are owed around $215 million in cash and cryptocurrency.
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Mighty Casey Baseball
Baseball Research and Other Random Musings
Baseball 365
Category Archives: Minnesota Twins
If the Astros play a game and nobody watches, does anybody hear the applause?
Posted on April 9, 2014 by Paul Proia
The best fastball in baseball may belong to Royals rookie Yordano Ventura, who hit 102.9 MPH against the Rays. He averaged 99.5 MPH on his fastballs over six innings of work. The pitch that nearly hit 103 was his 93rd of the night… [MLB]
SOMEBODY must have been watching… Unfortunately, none of them have a Neilsen TV-Set Top meter reader. The Houston Astros game got a 0.0 share, losing even to the pre-game show, on Monday night. The team has had several losing records – bad records – and is in Chapter 11. [SI]
Josh Hamilton dove into first base on a grounder and tore the ulnar collateral ligament in his left thumb. He should be out nearly two months. And that, kids, is why they don’t let you slide into first base in Little League, much less head first. [ESPN]
Hamilton’s former teammate, Adrian Beltre, is getting a strained left quad looked at. He left Tuesday night’s game unable to run. As insurance, the Rangers called up Kevin Kouzmanoff from the minors. [ESPN]
After nearly 2000 games in the MINORS, Pete Rose, Jr. still is trying to get back to the majors – as a manager. Who knew? [SI]
And when is a mascot not a mascot? When he only appears in the plazas and not necessarily on the field. The Dodgers say that the un-mascots are “unique performance characters“. Yikes… [SI]
Hurry Back!
Tampa sends starter Mike Moore to the DL with a sore left elbow.
The Dodgers send A.J. Ellis to the DL for knee surgery.
Miami sends Jacob Turner to the DL for a right shoulder strain.
Seattle loses starter James Paxton to the DL wiht a strained latissimus dorsi muscle (it’s in his back).
Minnesota sends Oswaldo Arcia to the DL with a right wrist strain.
Josh Beckett rejoins the Dodgers.
Craig Breslow returns to Boston.
Off to Rehab:
Taijuan Waker, Mike Minor, Tyler Chatwood, Freddy Galvis, Dane De La Rosa, and Jeff Locke
Baseball 365:
Arrivals:
(1870) Ollie Pickering
Pickering came from the Texas League and hit a couple of bloop hits as a rookie. Naturally, those bloop hits became known as Texas Leaguers – a term occasionally still used today.
(1879) Doc White
(1888) Hippo Vaughn – great Cubs pitcher from days gone by
(1909) Claude Passeau – sticking with the Cubs pitcher theme…
(1946) Nate Colbert – Padres power hitter of the early 1970s
(1961) Kirk McCaskill
(1965) Hal Morris
(1981) A.J. Ellis
(1985) David Robertson
Departures:
(1982) Francisco Barrios
Barrios was just 28; died of a heart attack.
(1995) Bob Allison – KU fullback, Twins hitter.
(2001) Willie Stargell
(2009) Nick Adenhart
Nick Adenhart was a passenger in a car when it was hit by a drunk driver and he died. Adenhart had just made his first major league start of 2009 and had recently left the ballpark. I remember when this happened and wrote about it briefly here.
(1913) Ebbets Field opens with a loss – the Phillies take Brooklyn, 1 – 0, before 10,000 fans.
(1947) Commissioner Happy Chandler suspends Leo Durocher an entire season for conduct detrimental to baseball.
(1962) Houston tops the Yankees, 2 – 1, in an exhibition game at the new Astrodome. Mickey Mantle homers. There was grass in there, you know. The turf came later because grass couldn’t grow after they painted the windows in the roof to help fielders track fly balls….
Posted in Atlanta Braves, Boston Red Sox, Cincinnati Reds, Florida Marlins, Kansas City Royals, Los Angeles Angels of Anaheim, Los Angeles Dodgers, Minnesota Twins, Philadelphia Phillies, Seattle Mariners, Tampa Bay Rays, Texas Rangers | Leave a reply
Happy Anniversary, Hammerin’ Hank Aaron – and other stuff…
The Rockies are going to play it safe with Troy Tulowitzki. Tulo homered among three hits, made two great plays at short – and then left the game to protect a frail groin and deal with tightness in his leg. [MLB]
It was a rough day in Tampa. Ray starter Matt Moore left the game with an injury to his left elbow. Later, Rays reliever Heath Bell drilled Royals infielder Omar Infante in the jaw with a pitch. Infante left the game with a possible concussion and will have his jaw tested for a possible fracture. [MLB/SI]
Tigers pitcher Evan Reed is wanted for questioning and likely will face a sexual assault complaint when the Tigers return to Detroit. [SI]
Dodgers catcher A.J. Ellis is scheduled to have arthroscopic surgery on his left knee for a meniscus tear. He injured himself running the bases on Saturday. It’s the second such surgery on the same knee in two years. [SI]
Yankees closer David Robertson likely heads to the DL after straining a groin, hopefully his own, in an outing against Toronto. An MRI revealed a grade one strain. [ESPN]
KC placed reliever Tim Collins on the DL with a left elbow strain, and pitcher Francisley Bueno on the DL with a sprained middle finger. Joining the roster are lefty Donnie Joseph and Michael Mariot.
Minnesota placed infielder Jason Bartlett on the DL with a sprained ankle. The Twins recalled C Chris Herrmann to take Bartlett’s spot on the roster.
Texas placed starter Joe Saunders on the DL with a bruised left ankle. Texas brings back RHP Daniel McCutchen.
Rockies pitcher Boone Logan, Oakland pitcher Ryan Cook, and Reds catcher Devin Mesoraco returned from the DL.
That Didn’t Last Long…
Boston sent Brock Holt back to the minors after having signed Ryan Roberts to a contract.
The Yankees worked out a trade that sends Eduardo Nunez to Minnesota for pitcher Miguel Sulbaran.
Cleveland traded pitcher Preston Guilmet to Baltimore for infielder Torsten Boss.
(1859) Lady Baldwin
Had a short career in the 1880s, but for a couple of years was a very good lefty pitcher. His nickname, Lady, came about because of his overly gentlemanly ways and his frequently demonstrating nervousness and fear in public situations.
(1915) Kirby Higbe
(1943) John Hiller
(1946) Jim “Catfish” Hunter
Five World Series teams, and the ace of the great As teams of the early 1970s. Didn’t mess around, threw strikes, and got the job done.
(1954) Gary Carter
Like Hunter, left us way too soon. Great catcher, always looked like he was having fun.
(1979) Jeremy Guthrie
(1983) Chris Ianetta
(1986) King Felix Hernandez, Carlos Santana
(1987) Yonder Alonso
(1978) Former Commissioner Ford Frick
(2005) Eddie Miksis
(1963) The Tigers sign Denny McClain, who had been placed on waivers by the White Sox.
(1922) According to Baseball-Reference.com, the Cardinals debuted their new uniform, which includes two birds on a bat with the word Cardinals across the front in a pre-season exhibition game against the Browns.
(1969) Opening Day for four expansion teams – all winners. Kansas City, Montreal, Seattle, and San Diego all open their first seasons happily…
(1974) Hank Aaron hits his 715th homer, passing Babe Ruth, off of Al Dowling in Atlanta. [MLB]
(1994) Kent Mercker fires a no-hitter as Atlanta tops the Dodgers. It was Mercker’s first complete game.
Posted in A.J. Ellis, Baltimore Orioles, Boone Logan, Boston Red Sox, Brock Holt, Chris Herman, Cincinnati Reds, Cleveland Indians, Colorado Rockies, Daniel Joseph, Daniel McCutchen, David Robertson, Detroit Tigers, Devin Mesoraco, Eduardo Nunez, Evan Reed, Francisley Bueno, Jason Bartlett, Joe Saunders, Kansas City Royals, Los Angeles Angels of Anaheim, Matt Moore, Michael Mariot, Miguel Sulbaran, Minnesota Twins, New York Yankees, Oakland A's, Omar Infante, Preston Guilmet, Ryan Cook, Ryan Roberts, Tampa Bay Rays, Texas Rangers, Tim Collins, Torsten Ross, Troy Tulowitzki | Leave a reply
Celebrating Victories, Thumbs, and Catchers
Congratulations to Ron Gardenhire for winning his 1000th game as manager of the Minnesota Twins. Only ten managers have done that with the same team. [FoxSports]
Not an MLB story, but interesting nonetheless. Auburn pitcher Jay Wade was supposed to issue an intentional pass to Austin Anderson of Ole Miss. He didn’t. The video captures the rest of the story. [FoxSports]
Will Middlebrooks heads to the DL with a calf strain. An MRI is forthcoming. Meanwhile, Brock Holt gets some time with the parent team. Holt came through the Pirates chain and has had two previous trips to the bigs (Pittsburgh and Boston), hitting .250 in 124 at bats. He’s a contact hitter, some speed but not a ton, and not a lot of power. That makes him, what, a poor man’s Bill Mueller? [MLB]
Yankee first baseman Mark Teixeira heads to the DL with a right hamstring pull. Austin Romine will get his spot on the roster. [SI]
Scott Hairston heads to the DL with a left oblique strain, which means that backup outfielder Tyler Moore returns to the Nationals. [MLB]
Yasiel Puig injured his thumb sliding into first base on an infield single. He stayed in the game – even forgot how many outs there were on a late game fly ball… Anyway – he expects to get an xray soon. [MLB]
Speaking injured thumbs – Ryan Braun has been struggling with a thumb injury for nearly a full year now, and even the rest he got while sitting out last year for steroid usage didn’t help. [ESPN]
National third baseman Ryan Zimmerman may have reinjured his shoulder on an awkward throw in Saturday’s game against the Braves. [MLB]
Jon Niese returns to the Mets after his turn on the DL.
More Rehab…
Cole Hamels, Chris Stewart, Dane De La Rosa, Brian Wilson, Craig Gentry, Jake Arrieta, and J.A. Happ head off to minor league rehab assignments.
(1903) Mickey Cochrane – Hall of Fame catcher – probably the greatest one prior to the arrival of Yogi Berra.
(1908) Ernie Lombardi – one of the best hitting catchers, a two-time batting champ, and another member of the Hall of Fame.
(1937) Phil Regan – earned nickname, “The Vulture”, because he would swoop in as a reliever and take wins at the end of the ballgame.
(1943) Marty Pattin – I’ve probably written this before. The first time that I bought my own pack of baseball cards was when I was probably six years old. I took a quarter down to a corner store near where my grandparents lived on Sacramento in Chicago and bought a pack of Topps baseball cards. There were no Cubs in that pack, and no other stars that caught my attention. The one guy who stood out, to me, was Marty Pattin.
Pattin was born in the western suburbs of Chicago. When his career – a good one – wound down, he would become the manager of the Kansas Jayhawks baseball team – but he left one year before I started broadcasting their games. I believe he still lives in the Lawrence area, and I wonder if he ever heard my call.
Anyway – whenever I see his name, I think back to that first pack of cards.
(1951) Bert Blyleven – Hall of Fame pitcher and, like Jack Morris, the topic of enormous debate as to whether or not he was actually good enough to get the nod. Chris Berman gave too many players nicknames in the 1980s and 1990s – but of the Bermanisms, Bert “Be Home” Blyleven was the best.
(1964) Kenny Williams – outfielder turned GM.
(1969) Bret Boone – another cheater, had some very big seasons in the 1990s.
(1971) Lou Merloni – my memory of Lou is that he was the guy who said that the Red Sox trainers used to give lessons in proper steroid taking…
(1909) Doggie Miller
George Frederick Miller was born 15 August 1864 and with just a year of minor league ball was playing for Pittsburgh. Miller was an agile catcher, a good hitter, and decent baserunner – which should have been enough to endear him to a generation of fans. However, he had something uniquely special – and that was a remarkably loud voice. So, when given the opportunity to coach the baselines, Miller would be heard all throughout the grounds – if not outside the grounds and a few blocks away.
His coaching voice was so loud it earned him the nicknames of Foghorn and Calliope. The other nickname – Doggie – had to do with his rather unique batting stance. A short, thin player – he propped himself even lower, and then he would kick forward with his front leg – almost like a dog taking a leak – before he would lean forward and slash at the ball. Having been teased, Miller actually tried to hit without kicking his leg out, but it was ingrained into his routine. He couldn’t hit without the kick.
Like many of the players of the 1880s and 1890s, he endured regular changes in the rules and equipment. One change he didn’t necessarily take to was the chest protector. A good enough player early in his career, Miller was often playing other positions to stay in the lineup – as his career wound down, he would eventually become the first player (and still only player) to play at least 20 games at every non-pitching position.
When his major league career ended in 1896, he wound up playing and managing in the minors, Sadly, Miller contracted Bright’s Disease, however, and left this world before his 45th birthday.
(Summary thanks to my new favorite book – Major League Player Profiles – 1871 – 1900.)
(1975) The Astros purchased Joe Niekro from the Braves.
(1973) Ron Blomberg becomes the first designated hitter, drawing a walk off of Luis Tiant. The second DH was Orlando Cepeda, who batted in the second inning of the same game.
Posted in Austin Romine, Brock Holt, Chicago Cubs, Chris Stewart, Cole Hamels, Craig Gentry, Dane De La Rosa, J.A. Happ, Jake Arriata, Jon Niese, Los Angeles Angels of Anaheim, Los Angeles Dodgers, Mark Teixeira, Milwaukee Brewers, Minnesota Twins, New York Mets, New York Yankees, Oakland A's, Philadelphia Phillies, Ryan Braun, Ryan Zimmerman, Scott Hairston, Toronto Blue Jays, Tyler Moore, Washington Nationals, Will Middlebrooks, Yasiel Puig | Leave a reply
Miguel Cabrera’s 2000th Hit – and other fun stuff…
Charlie Blackmon has the first six hit game in Rockies history since Andres Galarraga went 6 – 6 in 1995. [SI]
It started off a little rocky, but Masahiro Tanaka won his first start with the Yankees, going seven innings and fanning eight. [MLB]
Josh Beckett isn’t coming back as soon as he had hoped. While making a rehab start, Beckett left his game in the fifth inning after injuring himself while fielding a bunt. Beckett is trying to return from thoracic outlet syndrome, but was put on the DL prior to the Dodgers going to Australia. [MLB]
Houston leadoff hitter Dexter Fowler was hospitalized with a stomach virus and likely will not play on Saturday either. [MLB]
Miguel Cabrera got his 2000th career hit – and it was a homer. My take on it is that Cabrera, if he stays healthy and productive, could finish with around 3800 career hits before it’s over – the closest anyone may come to Pete Rose for the forseeable future… [FoxSports]
Jason Kipnis signed a six year extension with the Cleveland Indians, worth $52.5 million, and a seventh year option could extend the deal into 2020. The Indians have been locking down young talent, having recently signed deals with Michael Brantley and catcher Jan Gomes. [MLB]
They said I had to go to rehab…
Those extending spring training with minor league stints include Cody Ross, Michael Bourn, Matt Harrison, Stephen Pryor, Devin Mesoraco, Mat Latos, Boone Logan, Craig Breslow, Ryan Cook, Gordon Beckham, Jeremy Affeldt, Taijuan Walker, Juan Carlos Oviedo, Jonathan Broxton, and Mike Adams.
Matt Kemp returned to the Dodgers…
White Sox pitcher Nate Jones strained a muscle in his left hip.
Mets outfielder Chris Young has a right quad strain.
A’s SS Jake Elmore has a strained left quad…
That must have been some 4th of July Party…
Daniel Murphy and Brian Duensing return from the paternity list, while Rays LF Sean Rodriguez heads to the paternity list… Congratulations!!!
Those celebrating with cake, cards, or remembrances on 4/4 included:
(1888) Tris Speaker
(1897) Lefty (Ray) Miner
(1916) Mickey Owen
(1924) Gil Hodges
(1941) Eddie Watt
(1942) Jim Fregosi
(1943) Mike Epstein
(1947) Ray Fosse
(1956) Tom Herr
(1975) Scott Rolen
(1987) Cameron Maybin
(1991) Martin Perez
(1876) Big Bill Dinneen – good pitcher, good bowler, decent enough umpire…
(1907) Sugar Cain
(1938) Ron Hansen – back when shortstops could field and usually couldn’t hit – and Ron was one of those guys…
(1951) Rennie Stennett – second sacker of those great 1970s Pirates teams.
(1985) Lastings Millege – one assumes he’s no longer a prospect… He hasn’t had a major league hit since 2011.
(1974) Fred Snodgrass
Fred Snodgrass is most famous for his dropping a fly ball in the 10th inning of a game in the 1912 World Series that contributed to the Red Sox coming back and beating the Giants. What is forgotten about that play is that immediately after the drop, Snodgrass was forced to play shallow with a runner at second. When Harry Hooper launched a fly to deep right center, Snodgrass ran like the wind to haul it in – and then rifled a throw back toward second that very nearly doubled off that runner. The Giants missed a shot at getting Tris Speaker out on a foul pop, which gave Speaker a chance to drive in the tying run.
When Snodgrass returned to his native California after his playing days, we would become a banker and major of Oxnard, CA.
Snodgrass is one of about two dozen players who were interviewed for Ritter’s “The Glory of Their Times” – and his story is a fascinating read.
Transactions and Events:
(1972) The Mets get Rusty Staub from the Expos for Ken Singlton, Tim Foli, and Mike Jorgensen.
(1977) The Yankees acquire Bucky Dent from the White Sox for Oscar Gamble, LaMarr Hoyt, Bob Polinsky, and cash.
Posted in Arizona Diamondbacks, Atlanta Braves, Boone Logan, Brian Duensing, Charlie Blackmon, Chicago White Sox, Chris Young - OF, Cincinnati Reds, Cleveland Indians, Cody Ross, Colorado Rockies, Craig Breslow, Daniel Murphy, Detroit Tigers, Devin Mesoraco, Dexter Fowler, Gordon Beckham, Houston Astros, Jake Elmore, Jason Kipnis, Jeremy Affeldt, Jonathan Broxton, Josh Beckett, Juan Carlos Oviedo, Los Angeles Dodgers, Masahiro Tanaka, Mat Latos, Matt Harrison, Matt Kemp, Michael Bourn, Miguel Cabrera, Mike Adams, Milwaukee Brewers, Minnesota Twins, Nate Jones, New York Mets, New York Yankees, Oakland A's, Ryan Cook, San Francisco Giants, Sean Rodriguez, Stephen Pryor, Taijuan Walker, Tampa Bay Rays, Texas Rangers | Leave a reply
Happy Birthday, Fenway Park! (And Goodbye, Pudge!)
Posted on April 20, 2012 by Paul Proia
Today, the Boston Red Sox are celebrating the 100th Anniversary of the opening of Fenway Park with any number of pre-game festivities followed by what should be a four and a half hour game against the New York Yankees. In honor of this festive moment, let’s go back into the archives of The Sporting News to get some insight into what some people thought of the old park back when it first opened in 1912.
Tim Murnane was writing occasional articles for The Sporting News back in the day and penned this article, which appeared on the front page on May 16, 1912.
Boston’s Odd Ways
Reasons for Poor Patronage at New Fenway Park
It’s Too Big for Fans to Exchange Pleasantries About Weather and They’re Used to Going in Another Direction
Boston, Mass., May 12 — Special Correspondence
{General discussion of how weather has disrupted much of the American League schedule…}
… For several reasons the attendance has been disappointing at the local American League grounds. The continued unpleasant weather, several games having been played in light rain storms, or on days when it was too cold for a man to sit outdoors in comfort, is the chief item of course. Then the fact that the park is not as handy to reach and get away from as the old park, has hurt some and will until people get accustomed to journeying in the new direction.
Some dissatisfaction among the kings of the bleachers, as they resent the idea of being pushed back to make room for the big grand stand, is also in evidence.
On account of the size of the park, and the entrances being on two widely separated ends of the grounds, I found much of the old sociability gone. At the old grounds, you were continually running into old friends, as grandstand and bleacher patrons passed through one long runway, to be distributed like a lot of mail to the various sections.
Games Have Also Dragged
The games at the American grounds have been exceptionally long drawn out, and Boston base ball is patronized mostly by out of town people, who are anxious to catch trains, and therefore will not attend games too long drawn out.
I am sure, however, that with improved weather and everything else connected with the running of the establishment, the old crowds will come back, and the fans grow warmer to the new park.
{Other Boston player related news…}
T. H. Murnane
Is Pudge the Greatest Ever?
Ivan Rodriguez filed the paperwork for his retirement, and is planning a formal announcement for Monday in Texas. The greatest defensive catcher of the last 25 years – at least going back to the days of Johnny Bench – Rodriguez single-handedly killed the running game, handled pitches with soft hands and a smaller than normal catching glove, and was quite proficient with the bat. In 1999, he was the AL MVP after hitting .332 with 35 homers, too. Down here in Florida, the one year we had Pudge, the Marlins won the World Series. In his best seasons, he had to be as valuable as any player ever. [SI]
Let the argument begin – let me know what you think!!!
For a cool 18 million – two million less than the original asking price – you, too, can own Derek Jeter’s 88th floor, NYC penthouse atop the Trump World Tower at the UN Plaza in New York’s east side. [FoxSports]
Famous as the patch of felt between a baseball and Jose Canceco’s head, Heritage Auctions is selling the hat Canseco wore when he misplayed an out into a homer as the ball bounced off of Jose’s head and over the fence. The hat is autographed by Canseco and is expected to fetch about $1000. Stunning. [FoxSports]
Arizona placed third baseman Geoff Blum on the 15-Day DL with a strained left oblique.
Pittsburgh placed pitcher Jeff Karstens on the 15-Day DL with a right shoulder contusion. Brad Lincoln arrives from Indianapolis to help out… Lincoln is an okay minor league pitcher and hasn’t set the world on fire in two previous stints with the Pirates. He can help in long relief, maybe.
Arizona placed centerfielder Chris Young on the 15-Day DL with a right shoulder contusion suffered when crashing into the wall to make a catch. Young had been the hottest hitter on the Snakes…
The Yankees placed left fielder Brett Gardner on the 15-Day DL with a sore right elbow.
Transaction News…
Tampa claimed first baseman Brandon Allen off waivers from the Oakland A’s.
Minnesota called up Jason Marquis from AAA New Britain. The Twins need all the help they can get…
Boston sent down Mark Melancon to AAA – he of the ERA that is greater than Jamie Moyer‘s age – and recalled Japanese import Junichi Tazawa. In the minors, Tazawa hasn’t been half bad, but his career ERA in the majors is 7.31… Still, 7.31 is less than 49.50.
A trip to NYC and a lack of writing time means I am behind in my birthday celebrations. First – here’s a list of those celebrating with cards, cake, or remembrances today…
(1876) Charlie Hemphill
(1891) Dave Bancroft, Hall of Fame shortstop
(1929) Aristotle George “Harry” Agganis – The Golden Greek… (See below)
(1946) Tom Hutton – see you on TV this weekend!
(1961) Don Mattingly
(1973) Todd Hollandsworth
(1988) Brandon Belt
Harry Agganis was an All-American back at Boston University who turned down a career in football and a $100,000 bonus to sign with the Cleveland Browns to sign with his hometown Boston Red Sox in 1952. Sammy White said Agganis had the strength of Hercules… Two years after signing, Agganis had earned his way into a regular position with the Sox and was batting over .300 in 1955 when he was admitted to a local hospital with pneumonia and what was called phlebitis in his leg. Days later, Agganis died when a blood clot in his leg moved into his lung and burst. [Baseball Players of the 1950s – Rich Marazzi and Len Fiorito]
Belated Birthday Greetings to…
(April 19)
(1894) Jiggs Donahue
(1908) Babe Phelps
(1909) Bucky Walters
(1915) Harry Craft
(1918) Whitey Kurowski
(1948) Rick Miller
(1960) Frank Viola
(1961) Spike Owen
(1974) Jose Cruz, Jr.
(1977) George Sherrill
(1983) Joe Mauer
(1983) Zach Duke
It’s really a good list and I left a few names off…
(1880) Wahoo Sam Crawford – a great outfielder on the Tigers for a long, long time.
(1939) Von McDaniel (Lindy’s brother…)
(1942) Steve Blass
(1951) Doug Flynn
(1959) Dennis Rasmussen
(1959) Rich Bordi
(1959) Jim Eisenreich
(1970) Rico Brogna
(1983) Miguel Cabrera
(1986) Billy Butler
Posted in Arizona Diamondbacks, Baseball History, Boston Red Sox, Brad Lincoln, Brandon Allen, Brett Gardner, Chris Young - OF, Geoff Blum, Jamie Moyer, Jason Marquis, Jeff Karstens, Junichi Tazawa, Mark Melancon, Minnesota Twins, New York Yankees, Oakland A's, Pittsburgh Pirates, Tampa Bay Rays | Leave a reply
Ellsbury Out With Separated Shoulder, and Happy Birthday, Ben Tincup!
The Boston Red Sox placed centerfielder Jacoby Ellsbury on the 15-day DL due to a separated shoulder suffered when he was removed in the front end of a double play against the Rays. Ellsbury could miss at least six weeks, so if this is YOUR fantasy baseball team, you’ll want to know that Cody Ross will get the bulk of the starts, even though AAA outfielder Che-Hsuan Lin (more Lin-sanity???) was called up from Pawtucket. Lin doesn’t have the minor league resume that screams out START ME! – but you never know. He makes contact, he can run, and he covers ground in the outfield. Bobby Valentine, in his “boy am I smart” way explained that Lin might not be here longer than the weekend. [MLB]
The Detroit Tigers activated infielder Brandon Inge, who will likely get a start at second base this weekend. To make room, Detroit sent infielder Danny Worth to AAA Toledo. Meanwhile, the Tigers gave an unconditional release to outfielder Clete Thomas, who was promptly picked up by Minnesota. The signing of Thomas means that outfielder Ben Revere was optioned to AAA. [MLB, ESPN]
It’s okay, I’ll still follow Revere on Twitter. He seems like a nice kid.
Seattle placed reliever George Sherrill on the 15-Day DL with an elbow strain. In his place, the Mariners have recalled lefty pitcher Charlie Furbush.
Washington outfielder Rick Ankiel came off the DL, which means that Brett Carroll was designated for assignment.
The Transaction Wire…
The Phillies signed free agent infielder Mike Fontenot.
The Angels called up David Carpenter from AAA Salt Lake City. The Angels are looking for depth in the bullpen and Carpenter might be able to help immediately. He has remarkable control, a great strikeout rate, and minor league hitters have batted just .207 against him.
Those celebrating with cake, cards, and remembrances include:
(1893) Ben Tincup (See below)
(1927) Don Mueller (See below)
(1931) Kal Segrist (See below)
(1941) Pete Rose, the greatest singles hitter and baseball gambler ever.
(1947) Joe Lahoud – wow, he’s 65?
(1966) David Justice, Braves outfielder now portrayed in the movie Moneyball…
(1966) Greg Maddux, the best pitcher I ever saw… I loved Clemens and Carlton, don’t get me wrong, but Maddux was an ARTIST.
(1969) Brad Ausmus, longtime catcher
(1970) Steve Avery – which means at least three Braves were celebrating birthdays on the same day each spring in the early 1990s. At least for a couple of years, anyway…
(1976) Kyle Farnsworth
I’ve been writing this blog on and off for a long time, I guess… This is an odd day in that I have actually written small biographies for two players on this list. Go figure.
If you want to learn more about Giants outfielder Don Mueller, click here…
If you want to learn more about Yankee Infielder and Texas Tech baseball coach Kal Segrist, click here…
Ben Tincup
A baseball lifer, Austin Ben Tincup spent fifty years playing and teaching baseball to thousands of kids all over the country – but not before he became the first Native American from Oklahoma to make it to the big leagues.
In doing the research, I found four different birthdays listed for Ben. A couple of places, including FindaGrave.com and the Baseball-Reference.com Bullpen biography of Tincup, show his birthday as December 14, 1890. Baseball-Reference.com has a main player page and a minor league player page for Tincup, too. Those show April 14, 1893. His obituary and his grave stone in Rose Hill Cemetery in Tulsa, OK says his birth year is 1894. (You’d think that the findagrave.com mini-bio would want their data to match the picture, right?) SABR and Retrosheet.org, as well as the database I use for compiling this data, say 1893. Let’s go with that one…
Tincup was born on April 14th, we’re pretty sure, to James and Lucinda (Vance) Tincup. A TSN article listed Ben’s birthplace as Sherman, TX, but other sources say Adair, OK. (I’m tempted to go with Adair, mostly because the TSN writer probably read that Tincup came from Sherman when he joined the Phillies, but that was his minor league city and not his birthplace.) Not long out of school, Tincup was signed to pitch for Muskogee in the Oklahoma State League, the first professional team to operate in Muskogee. By the end of the 1912 season, though, he had been shifted to Sherman in the Texas-Oklahoma League. He stayed in Sherman for 1913, figured things out, and won his last fourteen starts.
The winning streak got him noticed, and the Philadelphia Phillies brought him out for spring training to see how he’d fare. Before long, the young Cherokee Indian was making relief appearances in May and June. In July, he was given his first major league start against the Pittsburgh Pirates. Tincup pitched a masterful game, winning 1 – 0, and holding the Pirates to just five hits – three of them by Honus Wagner.
Tincup became a bit of a celebrity and the newspapers called him The Millionaire Indian, one of many landowners who got rich when oil was found on a number of large farms in Oklahoma. Ben countered, however, that the writers missed their mark. “The stories were only half right,” said Tincup. “I’m 100 percent Cherokee Indian and I own 500 acres of Oklahoma land. But I’m the Indian who owns land where they didn’t find oil.”
Among the first Native Americans not nicknamed “Chief”, Tincup won two other games by shutouts: a 1 – 0 blanking of St. Louis and a 2 – 0 win over the Pirates. However, he mixed in a few rougher outings, including a 13 – 5 loss to Brooklyn and 12 – 3 loss to Boston. When the year was out, he finished 8 – 10 as the third starter on the roster.
However, the fourth starter was lefty Eppa Rixey, a fine thrower out of the University of Virginia. Rixey roomed with Tincup for a year while the rookies found their way through the league. In 1915, Rixey made the step forward, joining Grover Cleveland Alexander and Erskine Meyer and New York Giant import Al Demaree. The new rotation helped propel the Phillies to their first pennant in 1915. Tincup was reduced to a marginal reliever, making just ten appearances, and hardly contributing to the 1915 National League championship. In fact, Tincup was voted just a half-share of the team’s post-season take.
The Phillies chose to dispatch Tincup to the minors for a little more seasoning. In 1916, Tincup went 16 – 11 for Providence in the International League. Moved to Little Rock in 1917, Tincup threw a perfect game against Birmingham in the Southern Association. He kept a ball and the press clippings for years – the ball finally being donated to the Will Rogers Museum in Claremore, OK.
St. Louis claimed Tincup for the 1918 season, but the National Association ruled that Tincup still belonged to the Phillies, who called him up for a few outings. Tincup decided to retire and went off to join other Americans in the US Army who were fighting in Europe during the first World War.
When he came back in 1919, he was declared a free agent. Bill Neal, who had scouted and signed Tincup for Philadelphia, was now associated with the Louisville Colonels in the American Association. Neal signed Tincup for more money than he might have made with the Phillies – and Tincup became a minor league lifer. For the next twelve seasons, Tincup was a regular starter and later a reliever for the Colonels. He won 20 twice; the first time he went 20 – 14 in 1922, and two years later he won 24 games. And he could hit, too. One year, he played left field when he wasn’t pitching and wound up hitting .331 with 16 doubles, 16 triples, and eight homers. He missed the batting crown by four points. However, the next season manager Joe McCarthy and Tincup decided pitching was the right thing to do – and Tincup only played the outfield in emergencies.
The 1921 team won the American Association and challenged Baltimore in the Little World Series, a battle between the top minor league teams. Louisville won, in part, behind the pitching of Tincup. Tincup outdueled Lefty Grove to put Louisville in charge of the series.
In 1922, Harry Davis, the old Athletics first baseman, was sent to scout the team. He was looking at two players, Brewers outfielder Al Simmons and Colonels outfielder Earle Combs. Davis asked Tincup to really bear down on Simmons to see what he could do.
“I brushed Al back with a high, inside pitch. I had plenty on it, believe me,” said Tincup. “I wanted to scare Simmons, but he didn’t scare at all. Instead, he just just dug in and dared me to come back with the same pitch. I did. He didn’t move an inch. The next ball was a dandy curve. Simmons whacked it over the first baseman’s head for a triple. I figured he just had beginner’s luck. The next time he came up he lined a double to left… Some time later I read that Simmons had been sold to the Athletics for $100,000. I wasn’t surprised. When I saw Davis later, I told him that I had helped ‘sell’ Simmons to the A’s the day I pitched to him. Davis had a smart comeback. ‘You’re right, Ben. But I made a mistake. The day we bought Simmons, we also should have bought Combs.'”
Combs signed with the Yankees – and years later, well after he was done playing, Tincup would join the Yankees, too.
In the winters, Tincup would play ball in Cuba. The 1925 Marianaos Gray Monks may have been the best team of his generation, featuring players such as Freddy Fitzsimmons, Jess Petty, Otto Krueger, Mike Griffen, Charlie Dressen, Eddie Brown, Mark Koenig, Walter Christensen, Tiny Chaplin, Bill Burwell, and Jim Cooney. Some of those names we still recognize today – others, we’d probably have to look up.
Toward the end of his Louisville career, Joe McCarthy was with the Cubs – he needed a temporary reliever. He called for Ben Tincup, who got a couple more appearances in the majors. Then, he was returned to Louisville. As he got older, Tincup left the rotation and became a quality reliever. According to a TSN article:
“Manager Allan Sothoron this spring decided that the veteran redskin could best serve his team in the role of relief chucker, and in this capacity Ben has proved invincible.” He would finish the season 14 – 3 in relief, and another article claimed that he “…saved approximately 13 games, for which other pitchers received credit.” Jerome Holtzman hadn’t yet coined the term “Saves.”
1930 was Tincup’s last hurrah. He had a rough year (7 – 16) in 1929 and was given a pay cut. After 1930, he wanted a raise and Louisville ownership didn’t agree. Before long, Tincup was cut and scooped up by Minneapolis. The next year, Tincup was pitching in Sacramento in the Pacific Coast League, but he was pretty much done as a pitcher.
Instead, he was signed as am umpire by the American Association – a job that barely lasted two months. Per a blurb in TSN:
“Ben Tincup, veteran Indian pitcher formerly with Louisville, has been released as an umpire in the American Association by President Thomas J. Hickey. Tincup made his debut as an arbiter this season, but there were so many complaints over his decisions on balls and strikes that his release resulted.”
He went back to his farm in Oklahoma for the next three years.
However, guys who knew Tincup needed scouts and coaches – and Tincup was hired by the Cincinnati Reds to manage their farm team in Paducah, a member of the Kitty League. In his first season, Tincup led Paducah to a first-half crown and a trip to the playoffs. However, Tincup argued that two pitchers that helped Union City to a second half crown should have been ineligible. When that protest failed, he began to lose favor with his Paducah owner, B.B. Hook. Tincup next complained that he had to play night games in Union City, when his team only played day games at home. That, too, failed.
So, Tincup told his team to play but he was going to stay home to protest the league’s decisions. After Paducah lost to Larry Irvin (one of two players Tincup felt should not have been eligible to pitch) and Union City in that first game, seven other players decided to side with Tincup. The series was forfeited to Union City and National Association President W. B. Bramham chose to put Tincup and the seven players on the ineligible list. That ban lasted about four months, and Tincup was signed to manage a different Reds farm team, this one in Peoria, Illinois.
While there, Tincup traded for a pitcher who had been successful for him in Paducah, Gene “Junior” Thompson. Thompson was the ace of the Peoria staff and the Reds soon promoted him to the big league team where Junior (he hated that nickname) helped the Reds win the 1940 National League Pennant. Thompson’s ascent and Tincup’s role in his development earned Tincup the reputation as someone who could mold young pitchers.
Tincup was a proponent of throwing strikes, saying that the biggest problem young pitchers have is not being willing to hit the catcher’s glove. “They’re so scared somebody is going to get a base hit they throw all around the target but seldom at it,” said Tincup. “What they don’t realize is that even when you put across a perfect strike with nothing on it, the batter won’t hit it safely more than three times out of ten. That’s proved in batting practice.”
By 1938, he was taken by Larry McPhail from Cincinnati to Brooklyn to become a roving pitching instructor and coach. In 1939, young kids would have seen an advertisement for a California baseball camp where young ballplayers could learn from coaches like Leo Durocher, Charlie Dressen, Bill Killefer, and Ben Tincup. On the other hand, some things from his minor league days didn’t go away as quickly. Tincup earned a fine in his last days managing Paducah in 1939. When he tried to step on the field as a coach in 1940, the league told him he had a $10 fine due and Kennesaw Mountain Landis wouldn’t let him on the field unless he paid that fine. A wire was sent, and Tincup was allowed to coach.
After two more seasons as a coach, Tincup took a short hiatus to join the war effort for World War II – this time helping build boats on the docks of the Ohio River at Jeffersonville. During that time, he ran into an old friend – Ray Kennedy. Kennedy was Tincup’s catcher when Tincup tossed that perfect game in 1917 for Little Rock. Now, Kennedy was the General Manager for the Pittsburgh Pirates. Kennedy knew a few people – and by 1946, when the war was over, Tincup was a scout for the Boston Braves.
Tincup’s scouting and coaching career meant he went all over the place for a bunch of different teams. He left Boston to join the Pirates. Roy Hamey had brought him into the Pirates organization, and when he left for the Yankees, he took Tincup with him there, and then to the Phillies. “We had him traveling around the farm clubs and working with the pitchers,” said Hamey. “He helped fellows like Bob Friend and Vernon Law so much that when I moved over to the Yankees, I talked George Weiss into bringing him to New York. He did such a good job with the Yanks that I had a tough time getting him for the Phils. But I told Weiss I needed him worse than the Yankees did, so George turned him over to me.”
During his time with the Phillies, a prized prospect was a young Yaqui Indian out of Arizona named Phil Ortega. Hamey assigned Tincup to handle the negotiations, figuring that one Native American might be better able to relate to another Native American than the other scouts. The Dodgers, however, countered with a bigger bonus check. Buzzie Bavasi wired Hamey when he won. “How dumb can you get,” Bavasi asked. “Don’t you know Ortega’s and Tincup’s tribes have been at war for 300 years?”
The Yankees got Tincup back when Ralph Houk, who had used Tincup as a pitching coach in the middle 1950s, asked for him to coach his 1961 squad. Joe Falls wrote about it in the Detroit Free Press: “The Yankees have signed Ben Tincup, a 73-year-old Cherokee, as their minor league pitching coach… And this is the team that fired Casey Stengel because he was, at 70, too old.”
If Tincup was 73 in 1961, that would put his birth date at 1888… Another option… I don’t think so.
Anyway… Eventually baseball’s tribal elder called it a career and returned to the Tulsa area. He was inducted into various Halls of Fame in Oklahoma, including those celebrating Native Americans in sports. In 1980, he was staying at the very hotel in Claremore, the Will Rogers Hotel, where his perfect game baseball would have been on display. Sometime in the night on July 5, 1980 Tincup was called to pitch on the great ball field in the sky.
The Sporting News
“Finishing Second No Small Honor in A.A.” The Sporting News, Oct. 7, 1920, Page 5.
“Colonels Carry On and Never Say Die.” The Sporting News, July 14, 1921, Page 3.
“Didn’t Start A One But Has Won Seven.” The Sporting News, June 19, 1930, Page 4.
Williams, A. W. “Louisville Releases Tincup.” The Sporting News, July 30, 1931, Page 3.
“Ben Tincup New A.A. Umpire.” The Sporting News, January 19, 1933, Page 2.
“Tincup to Pilot Paducah” The Sporting News, March 26, 1936, Page 7.
“Bramham Punishes Paducah ‘Strikers’.” The Sporting News, September 24, 1936. Page 7.
“Long Arm of the Law.” The Sporting News, May 23, 1940, Page 3.
“Tincup Donates No-Hit Ball.” The Sporting News, April 10, 1941, Page 11.
“8-Game Streak Has Almendares Out in Front.” The Sporting News, November 17, 1948, Page 20.
The Sporting News, March 8, 1950, Page 14.
“Old-Time Ben Tincup Back; Gives Advice to Phils’ Kids.” The Sporting News, March 7, 1956, Page 33.
Notes, The Sporting News, January 1, 1961, Page 12.
Obituaries, The Sporting News, August 9, 1980, Page 50.
“Phils Forgot Tribal Wars When They Bid for Ortega.” The Sporting News, June 27, 1964, Page 26.
Obituary:
Claremore (OK) Progress (July 8, 1980)
Baseball Digest:
Bryson, Bill. “The Indian Glove Call.” Baseball Digest, Feb 1964, Pages 67 – 73.
Levy, Sam. “Simmons First Steps to Hall.” Baseball Digest, April, 1953, Pages 25 to 27.
Baseball-Reference.com
Posted in Baseball History, Ben Revere, Boston Red Sox, Brandon Inge, Brett Carroll, Charlie Furbush, Che-Hsuan Lin, Clete Thomas, Cody Ross, Danny Worth, David Carpenter, Detroit Tigers, George Sherrill, Jacoby Ellsbury, Mike Fontenot, Minnesota Twins, Philadelphia Phillies, Rick Ankiel, Seattle Mariners, Washington Nationals | Leave a reply
Easter, Fister, and “When is a Suspension Not a Suspension…”
The Tigers got four homers from their big cats, Miguel Cabrera and Prince Fielder, but took a hit as well. Doug Fister left the game in the fourth inning with a left costrochondral strain (he hurts in his ribs), placing the Detroit pitcher on the DL. Joining the Tigers will be Brayan Villarreal, a young arm who has a fan in Jim Leyland and impressed the team in spring training.
Villarreal is a reliever, though, so look for Duane “Look Out” Below to get the next two starts. [MLB]
Liam Hendricks, Twins starter, missed his start and may not be able to fly home with the team as he remains in a Baltimore hospital with a case of food poisoning. [FoxSports]
In a story that makes you wonder if he’s really going to get suspended… Ubaldo Jimenez plans to drop his appeal of a five-day suspension handed to him for deliberately throwing at Troy Tulowitski in a spring training game. The team backed his original appeal to get Ubaldo a start, and then pulled it because an off day in the schedule means that Jimenez can miss five days but not miss a turn in the rotation.
Maybe the league can extend his suspension to at least seven days so that he misses that turn. [ESPN]
Keeping with the expectations given to Ozzie Guillen, Guillen is apologizing for telling a Time Magazine reporter, “I respect Fidel Castro. You know why? A lot of people have wanted to kill Fidel Castro for the last 60 years, but that mother(expletive) is still there.” Guillen, no stranger to putting his foot in his mouth, admitted that when he first read it he thought he was going to get in trouble for it.
Guillen later explained that his respect for Castro has nothing to do with Castro’s politics or human rights history. “The reason I say I admire him,” says Guillen,”is because a lot of people want to get rid of this guy and they couldn’t yet.”
You have to like how Ozzie is trying to appeal to the large Cuban community that supports the Marlins. [FoxSports]
Best wishes go out to Bob Uecker and his family. Uecker’s son, Steve, died of Valley Fever – it happens when a fungus that enters the body through the lungs – one day short of his 53rd birthday on Friday. [MLB]
Those celebrating with cake, cards, and remembrances on this Easter Sunday include:
(1878) Clarence “Pop” Foster
(1934) Turk Ferrell
(1973) Alex Gonzalez
(1986) Carlos Santana
(1986) Felix Hernandez
(1987) Jeremy Hellickson
This might be the best pitching rotation of any birthday date… And, they’d be pitching to The Kid. I’ll take my chances with this group.
My niece, Kayla, is also celebrating a birthday today… Happy Birthday to the little girl who was the first grandchild for my parents!
Posted in Brayan Villarreal, Cleveland Indians, Colorado Rockies, Detroit Tigers, Doug Fister, Duane Below, Florida Marlins, Liam Hendriks, Miguel Cabrera, Milwaukee Brewers, Minnesota Twins, Prince Fielder, Troy Tulowitzki, Ubaldo Jimenez | Leave a reply
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BlackBerry’s BBM Video Calling Now Available on iOS and Android Devices
BlackBerry has made video calling available for BBM messaging users on iOS and Android devices.
Until now, this video calling feature on BBM was only available for BlackBerry 10 users who could video chat with other BlackBerry 10 users.
Now BlackBerry has extended this video calling feature to iOS and Android users.
The ‘beta’ version of this is now available for users in the US and Canadian.
BlackBerry said it’s restricting the initial availability to these two regions, in order to “monitor performance, gather feedback, and iron out any kinks,” prior to making this feature available worldwide in July.
BBM users can now finally have video conversations with users on Android and iOS devices.
Free BBM Video Calling on iOS and Android
The video calling feature is free without any fee, approval or sign-up requirement.
If you’re a BBM user, you just have to tap on the video calling icon and you’ll be asked if you wish to make a voice call or try a video call. Choose video and you’re on your way to a personal or a business video chat.
With BlackBerry having its own Android device, the BlackBerry Priv, it makes sense to bring the latest BBM versions to Android and iOS.
According to Pew Research, nearly 47 percent of adult smartphone users in the United States made a video call in 2015.
BlackBerry’s senior vice president of emerging solutions, Matthew Talbot said – “In business, live video helps people put faces to names, virtually meet job candidates, make decisions in real time, and save tremendously on travel expenses.”
With other messaging services like Facebook and WhatsApp abandoning BlackBerry, the company is doing everything possible to increase the appeal for BBM, which has a strong fan base and continues to be used widely.
Recently, the company made several privacy features free on the BBM app, which include the ability to retract messages as well as a Snapchat-like timer.
If you’re in the US and you own a BlackBerry Priv, why not check out the BBM video calling feature? Don’t own a Priv? Now with the permanent price cut, you might want to get your hands on one.
Of course you can use any Android or iOS device.
BlackBerry said the free video calling feature will work on Android 4.4 (KitKat) and higher devices, and iOS 8 and higher.
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All fields: fabulous
Save to favorites Cuban music group Senén Suárez performing at the Tropicana Nightclub in Havana, Cuba
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Save to favorites Pan American clipper, Vol. 6, No. 16, September 10, 1947
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Save to favorites Pan Am news briefs, Vol. 6, No. 25, June 18, 1970
Save to favorites Pan Am news briefs, Vol. 8, No. 22, June 1, 1972
Save to favorites Pan-Alaska news, Vol. 2, No. 2, February 15, 1944
Save to favorites Monthly operational bulletin, Issue 6, July 1991
Save to favorites Clipper, Vol. 3, No. 60, February 15, 1947
Save to favorites Clipper cargo horizons, Vol. 1, No. 3, March 1961
Save to favorites Pan Am clipper, Vol. 22, No. 4, February 15, 1971
Save to favorites Pan Am clipper, Vol. 21, No. 26, December 21, 1970
Save to favorites System sales clipper, Vol. 12, No. 2, February 1955
Save to favorites Sales clipper, Vol. 15, No. 11, November 1957
Save to favorites Quipper, No. 10 "Anniversary Edition", July-August 1982
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Moorside High School
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Moorside High School serves a wide and diverse area of Swinton, Greater Manchester. Our pupils, their families, our staff and other partners represent a diverse range of home backgrounds and cultures. We aim to deliver a curriculum that is reflective of modern Britain and incorporates the interests of pupils to support them in becoming good local, national and global citizens of the future.
The Department for Education states that there is a need ‘to create and enforce a clear and rigorous expectation on all schools to promote the fundamental British values of democracy, the rule of law, individual liberty and mutual respect and tolerance of those with different faiths and beliefs.’
Our school reflects British values in all that we do. We support and educate our pupils during their time with us in order to ensure that they grow into caring, responsible and tolerant adults who make a positive difference to British society and to the wider world. We encourage them to be creative, unique, open-minded and independent individuals, respectful of themselves and others in our school, our local community and beyond.
At Moorside, we actively promote British values in the following ways:
Pupils are encouraged to debate topics of interest, express their views and make a meaningful contribution to the running of the school. They are able to do this in a number of ways e.g. through pupil voice activities; school council; questionnaires and surveys; assemblies.
We have a clear positive ‘Ready to Learn’ policy which helps pupils to make positive choices about their behaviour. Through our Pastoral Curriculum, pupils are helped to distinguish right from wrong. There is an expectation that this is reflected in the classroom, during assemblies and in the playground. This is supported by a Restorative Justice approach. Pupils are encouraged to respect the law and Moorside High School actively encourages visits from services such as the Police, Fire and Ambulance services to help reinforce the message.
At school, pupils are encouraged, and given the freedom to make choices, knowing that they are in a safe and supportive environment, e.g. challenging themselves in their learning. They are supported to develop self-knowledge, self-confidence and a growth mindset in all areas of school life. Pupils are taught to understand and exercise their rights and personal freedoms in a safe way, e.g Form Time Curriculum; PSHE lessons. They have key responsibilities in school such as Peer Mentoring; Prefects; Language Ambassadors.
Mutual Respect and Tolerance of Those with Different Faiths and Beliefs
Our core values are Believe, Achieve, Succeed, Together. The latter of these reflects the mutual respect that underpins the ethos of the school. Pupils understand that respect is expected to be shown to everyone, both adults and children. We help them to develop an understanding of, and respect for, their own and other cultures. Staff and pupils are encouraged to challenge prejudicial or discriminatory behaviour.
Links with local faith communities and visits to places of worship are promoted and people from different faiths are invited to school to share their experiences in assemblies and in class. Through the PSHE and RE curriculum pupils are encouraged to discuss and respect differences and similarities between people. We offer a culturally rich and diverse curriculum in which all major religions are studied.
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India vs South Africa Prediction
Myarbets
Gandhi-Mandela Series: India vs South Africa Prediction, Preview and Betting Tips
India will take on South Africa in the fourth ODI match of Gandhi-Mandela Series at MA Chidambaram Stadium in Chennai on Thursday noon, with India aiming to win this game in order to keep their challenge alive in the series and South Africa will be hoping to wrap up a win before the final game on Sunday. Team India needs to win this match here to keep the series alive as South Africa lead the series 2-1 and just need a win to lift the trophy.
India is in terrible run of form throughout the season. India have got good bowling attack in the tournament but are lacking on the batting end as their top order batsman Shikhar Dhawan, Virat Kohli, Suresh Raina and Ajinkya Rahane are out of form. India started their campaign with a defeat against South Africa by 18 runs followed by a win in the second ODI match by 22 runs made South Africa all out at 43.4 overs, but their good performance came to an end in the third ODI as India choked to an 18-run defeat against South Africa at the Saurashtra Cricket Association ground in Rajkot.
South Africa are in excellent form during the entire season and have played very good cricket in India. The team has lost only one single ODI match this season while they already won the T20 series by 2-0. The South African Team have undoubtedly the solid batting lineup in the series, which includes Quinton de Kock, AB de Villiers, Faf du Plessis, Hashim Amla and David Miller. The team has good middle order and solid bowling attack with the likes of Dale Steyn and Imran Tahir, but they have suffered damages due to injuries to their star players, JP Duminy and Morne Morkel. JP Duminy was ruled out in the last two ODIs due to hand injury, while Morne Morkel will miss the game due to his sore leg.
Both South Africa and India have explosive batsman, good pace bowling unit and great fielders in the squad. Considering the present performances and statistics, South Africa hold a little edge over India in this match. We predict South Africa will register a simple victory here.
India vs South Africa Prediction: South Africa to win @ 2.00 at William Hill Sports
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Wednesday, 22 January 2020 11:35 AM
Nagarik Shukrabar Nagarik Network
On scholarship diplomacy
Published On: August 30, 2017 01:30 AM NPT By: Trailokya Raj Aryal
Trailokya Raj Aryal
The contributor for Republica.
news@myrepublica.com
Being Xi
Foreign playground
Dangerous Doklam
One simple and cost-effective way to promote our soft power is to establish a competitive Nepal Scholarship Fund under the joint jurisdiction of our foreign and education ministries.
Nepal is poor, and hence it makes no sense to talk about promoting our soft power abroad, so goes our thinking. We tend to equate soft power mostly with development aid, political system, economy and overall “attractiveness” in the eyes of foreigners. And we know we are lacking in all these. We receive development aid, our political system is not something that others seem keen to emulate and while foreigners admire the natural beauty of Nepal, not many are interested to come here to live, work and study.
But this shouldn’t stop us from promoting our soft power abroad. All that is needed is determination and some money.
One simple and cost-effective way to promote our soft power abroad is to establish a competitive Nepal Scholarship Fund under the joint jurisdiction of Ministry of Foreign Affairs and the Ministry of Education, or as an autonomous body that provides deserving foreign scholars and graduate students grants to conduct research of their interest in Nepal, whether independently or through institutional affiliations.
We can start with SAARC member states—minus Nepal—and China. If we get two professors and two graduate students from each country, then that’s 32 foreigners a year. And if we provide the professors with US $25,000 and grad students with $15,000 for one academic year, that comes to $640,000 a year. Add another $50,000 a year will be spent on administrative expenses in Nepal and to pay to selection committee members in each country. That comes to around Rs 75 million a year. If you think it is a lot for a country like Nepal, then just read the news.
Big bangs for bucks
We lose billions a year in embezzlement. Almost 18 times the amount I have proposed is spent on paying the “extra” ministers in the present cabinet. We also spend millions each year to provide security to leaders who do not need that level of security at all. To be honest, Rs 75 million is probably lost in corruption in a day in our customs and tax revenue offices.
Therefore, this in no way would drain government coffers. But if it is reluctant to spend the money on something that will enhance Nepal’s image abroad—something we cannot rule out—then it can seek help from private businesses and wealthy individuals through something akin to charitable contribution deduction in the US. We can have a provision that allows private businesses and individuals to donate up to three percent of their annual income to the fund, and the government will deduct this amount from their total taxable income. If the three percent exceeds Rs 10 million, then they should be allowed to name the scholarship after their company or whoever they wish it named after. Just imagine the money the fund will have in a year!
Once the ball gets rolling, the fund can create its own university with distinguished faculty from Nepal and abroad, and with world class research centers. It will enroll scholarship recipients along with the best and brightest Nepali students in structured programs that lead to academic degrees. As things now stand, our universities are no magnets for the best students from abroad, and the fund can work at changing this.
When the “free of political influence and interference” research centers are in place, we can then expand the scholarship to Southeast Asian countries, along with Japan and Korea, and in a phase-wise manner, to other countries in Asia.
As I have written elsewhere, the fund can do a lot of other things as well such as gifting statues of Hindu and Buddhist gods to be placed prominently in college campuses of countries where the scholarship is not yet available so that students know where Nepal is and Google a few things about us. Now that is already better than they knowing absolutely nothing about us. They will easily associate the images they see in their college premises to Nepal. And I can vouch for this from my personal experience.
Cervantes the diplomat
There is a statue of Miguel de Cervantes in the premises of Peking University that was gifted to it by the city of Madrid. Until I saw the statue I knew nothing about the writer or even about Spain besides its football teams. But seeing him every day got me curious and made me Google him and to learn a few things about him. Although I am yet to read his famous work, Don Quixote, every time I hear of Spain, I associate it with Cervantes. Now that’s a win-win for the city of Madrid that gifted the statue and yours truly.
Because of that statue I got to know that Spain wasn’t lagging behind other European countries in producing great works in literature and it is much more than football teams and matadors. And the city of Madrid got me to know more about Spain.
Similarly, the fund can also gift books on Nepal, as well as digital facsimiles of ancient manuscripts and Nepali paintings, to university libraries abroad. With time, we can expand the scholarship to many, if not all, countries of the world and even fund graduate students focusing on Nepal in universities abroad.
You may very well ask, okay, but how does it benefit us? It will benefit us in many ways. It will rekindle the academics interest on Nepal abroad, and we too will greatly benefit from researches by both experts and young students on various aspects of our society.
Let’s admit it, we have been relying on outdated works by foreigners on Nepal. So this will help us see ourselves in a new light, and also bring to our attention things that we consciously or unconsciously leave out when studying various aspects of our own society.
Just to make sure that the work of scholarship is accessible to all, unlike the works of the past laden with academic jargons and only meant for scholars, the fund’s recipients should be asked to submit their findings/papers in plain and simple English. These will be published it in both English and Nepali and also be made available online.
Moreover, the scholarships will be our way of showing appreciation for the international community’s generosity. Most importantly, one day the graduate students who benefit from the scholarship can very well be in the position of importance in her country and will thus know how to deal with us and be more sympathetic to our needs, desires and positions on various issues—the real reason behind almost all scholarships provided by governments to foreign students.
To conclude, it’s us, our lack of vision, and our defeatist mindset that’s stopping us from enhancing our image abroad, nothing and no one else.
trailokyaa@yahoo.com
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Democrats Of Wasilla--unite!
By Noam Scheiber
I'm in Anchorage tonight after spending the last week or so in Wasilla. Without stepping on the piece I'm supposed to write, I can relate one of the more amusing (and heartening) scenes I observed in Alaska. It took place Friday night at a meeting of the Mat-Su Valley (i.e., Wasilla area) Democratic Party--a group of folks who, in the last three-plus weeks, have become the most motivated voters on the planet.
As people went around the room introducing themselves, one woman described how she "took down a teacher" at her daughter's high school who had an entire pro-Palin wall--full of posters, buttons, and other Palin-phernalia--but nothing about Obama. She complained to the administration and was pleased to report that "his wings have been clipped." The crowded whooped lustily. Another woman groused about all the "Go Sarah!" signs she sees at local businesses on her drive home. She urged a boycott. "If you skip that cup of coffee, don't go in there, they will get the message," she said. (At this point someone observed that the sign in front of the hotel where we were meeting also flashed the words "Go Sarah!" A brief discussion ensued about whether it was still appropriate to meet there, but was dropped when someone else said the manager of the hotel was simpatico and had no say in the matter.)
The brunt of this enthusiasm fell on the local Obama organizer, a tall twenty-something in a sock hat named Ryan Kopiasz. Kopiasz couldn't complete two sentences without being interrupted with a question--often as trivial as where to find the local Obama office, or when the next batch of signs and stickers (and fleeces!) would arrive. One amusing example: The campaign is encouraging supporters to contact undecided voters in swing states to make the case for Obama. Kopiasz explained that Missouri was the swing state with which the mother ship had paired Alaskans. At which point someone asked, "Why not Ohio?" "They're doing Ohio," Kopiasz said, "but they want us to do Missouri." The questioner was unpersuaded: "I think we should do Ohio," he said. Kopiasz demurred again: "The campaign feels that our values in the Mat-Su Valley line up really well with Missouri." This continued for several minutes.*
The highlight of the evening came when Kopiasz led a discussion about what Mat-Su Democrats might write their friends in Missouri. People should explain why they're supporting Obama, Kopiasz instructed, not why they oppose McCain and Palin. "Well, can we at least tell them we're from Wasilla?" one woman demanded. Kopiasz thought about it for a second. "Yes, but stay positive. We want the tone to be positive." Another person chimed in: "I think we should tell them what's wrong with Palin." Several people murmured their assent. "We want to stay positive," Kopiasz pleaded. "That's the tone we're going for..."
The crowd seemed resigned if not quite appeased. A blissful silence descended. Then, a few moments later: "I still don't know how to get to your office." Someone should give this guy a raise.
--Noam Scheiber
*This paragraph is written from memory--I didn't take notes on it for some reason--but the dialogue should be accurate to within a word here or there. I only included comments I remembered pretty vividly.
P.S. Special thanks to local Democrats Jim and Julie Ede for extending an invitation.
Business, Politics, Ryan Kopiasz
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Innovative materials help to drive greener and more durable roads
Graphene asphalt trial1
Graphene in hand
Graphene road
SK_Oxfordshire_Resurfacing_Trial_181119_(AP)154
Highways engineers are testing a new substance that could help keep more roads pothole free for the first time in Britain on a road in Oxfordshire.
Earlier this week, a joint trial was started by Oxfordshire County Council and its contractors, Skanska, to lay and test a fully recyclable, graphene-enhanced asphalt on a busy main road in Curbridge, near Witney.
Graphene – a specially developed ingredient that is added to otherwise ordinary surfacing material – has the potential to extend the life of roads and guard against potholes and other problems.
Graphene is also used in a wide range of other items including batteries, paints, printing, packing and sports items.
The substance was known about for many decades, but pioneering work done in 2004 in the UK led to two physicists winning a Nobel Prize, the development and commercialisation of the substance and ultimately its first UK road trial in Oxfordshire.
The works, which were delivered by subcontractor Aggregate Industries, involved removing and replacing a 750m stretch of road.
One lane was resurfaced using conventional materials - effectively acting as the control measure - while the opposite ‘trial’ lane was resurfaced using the asphalt enhanced by the innovative additive developed by Italian company Iterchimica.
Engineers will monitor how the new surface performs and it will take up to two years to get a full picture of how well it compares to the conventional materials. If successful, the new material will significantly increase the durability of asphalt used in road maintenance.
Oxfordshire County Council is also working with Skanska to test other new techniques and materials also aimed at reducing potholes and carbon to introduce more durable, futureproof road surfaces across the county.
Jason Russell, Oxfordshire County Council’s Interim Director Community Operations, said: “Oxfordshire County Council is always keen to explore new products and processes to not only improve the network for our residents, visitors and businesses, but more importantly to make sure that we maximise the resources we have and deliver as many improvements as we can.
“Working with Skanska, we recognised the opportunity to be at the forefront of developing new materials which will enhance the roads in the UK.
“We have taken the approach that trials are an important factor in pushing the boundaries and without the forward thinking we adopt, we would be behind the development curve and not be offering our residents the best we could offer in terms of spending public funds wisely.”
Jim Daughton, Skanska’s Operations Director, commented: “Exploring these new materials is about taking a new approach to tackling two of the biggest issues facing the highways industry and UK drivers – reducing potholes and improving the quality of our infrastructure for the future while driving down carbon.
“We’re always looking for new ways to provide best value and our innovative approach enables us to deliver better and more effective projects for our customers and their communities, so we’re delighted to be the first to trial graphene asphalt in the UK.
“If successful, this innovative product could transform highways maintenance in the UK, extensively extending the life of key highways infrastructure affected by significant traffic loads, while reducing carbon, which is key as we work with our supply chain to achieve net-zero carbon emissions by 2045.”
Traffic management Work is continuing to progress well on the current phase on Woodstock Road with three-way temporary signals controling traffic on Woodstock Road and Elizabeth Jennings Way. Oakthorpe Road and Thorncliffe Road will be closed …
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Home » Africa » Africa Top10 Business News
Africa Top10 Business News
1Morocco Inaugurates Africa’s Fastest Train
The train will halve travelling time between the commercial and industrial hubs of Casablanca and Tangier to two hours. King Mohammed VI and French President Emmanuel Macron boarded the train for the inaugural trip from Tangier to the capital Rabat. The train is planned to run at 320km, it’s about twice as fast as South Africa’s high-speed Gautrain and cost $2.4bn.
SOURCES: The East African, Al Jazeera
2How can Africa Boost Tax Revenues?
The IMF predicts that African countries can mobilise a further 5% of GDP from taxes over the next few years. It identified six countries that have pursued effective resource mobilisation strategies at various stages: Liberia, Mozambique, Rwanda, Senegal, Tanzania and Uganda.
SOURCES: African Business Magazine
3Africa Code Week Drives Inclusive Education with Coding Workshops
Africa Code Week’s coding workshops for hearing-impaired children in Mozambique are part of SAP’s broader commitment to the United Nations Sustainable Development Goals (SDGs), specifically Goal 4, which aims to ensure quality and inclusive education for all. The programme also gives credence to SDG goal 17 through sustainable partnerships with its Africa -wide partnership network.
SOURCES: Africa.com
4First Made-in-Africa Full-scale Smartphone Launched at the Africa Investment Forum
The Maraphone phone, a first-of-its-kind in the history of Africa, will produce high quality and affordable smartphones to primarily serve the population of Africa and also with the aim to export to other continents such as Europe.
SOURCES: Ventures Africa
5Everyone Wants a Piece of the Djibouti Pie
In July, Djibouti started the first phase of a $3.5 billion free trade zone. China, the U.S. and France together with Japan and Saudi Arabia, have military bases in Djibouti, ostensibly for fighting near-endemic piracy. In the future, Djibouti could cater to the rising volume of exports from Ethiopia’s manufacturing zones. Djibouti could also beef up its role as a transshipment hub to terminals farther down the African coast, such as Dar es Salaam in Tanzania, Maputo in gas-rich Mozambique and Durban in South Africa.
SOURCES: Ozy, VOA
6Zimbabwe’s Hyperinflation Days Loom a Year after Mugabe’s Departure
Statistics agency Zimstat said the annual inflation rate shot up 20.85% in October from 5.39% in September after the dollar shortage led to a collapse in Zimbabwe’s parallel currency called the bond note, triggering sharp price hikes in many goods and services. This is the highest level since 2008.
SOURCES: Business Day Live
7A New Farming Technique that’s Changed the Way Kenya Does Things
Tree hopping involves digging up mature trees where they grow close together and relocating them to areas in the forest where there is less. The technique is gaining popularity with Kenyan farmers who are trying to produce more food on limited amounts of arable land without further damaging the environment. Putting some more space between trees can let in more sunlight and make an area’s micro-climate more suitable for farming. Tree hopping allows farmers to legally thin out their forests while helping others boost the number of trees on their land, experts say.
SOURCES: VOA
8Nigeria’s Former Oil Minister to Face the Music
Three years after she was first arrested in London on money laundering charges, Nigeria is finally looking to bring home its former oil minister, Diezani Alison-Madueke, to face corruption charges. Alison-Madueke has been London since 2015 after being released on bail and having her passport seized following the arrest. She served as minister of petroleum—a key role in Nigeria’s oil-dependent economy—from 2010 to 2015.
SOURCES: Quartz Africa
9SA President Irons out the Land Issue
The land reforms in South Africa will not violate the country’s constitution says President Cyril Ramaphosa. South Africa’s ruling African National Congress aims to change the constitution to allow for land expropriation without compensation to address racial disparities in ownership that persist more than two decades after apartheid’s demise in 1994.
SOURCES: CGTN Africa
10Bleisure in Ghana
Traveling on business can be a big chore, especially if you are scrambling to get work done on a deadline. And it is at these times you need far more than just a good location and free coffee. Hotels in the capital, Accra give far beyond that and focus on meeting the needs of the most demanding business travellers.
SOURCES: AFK Travel
Africa Top10 News
Sri Lanka president rejects Rajapaksa no-confidence vote: lawmaker
Mother jailed for hiding baby in car boot
What Brexit could mean for Africa
Libya oil exports blocked, raising stakes for Berlin peace summit
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Mayo Clinic Minute: 2017’s top Mayo Clinic web searches
When people get sick and have medical questions, the first place they go is the web. Millions turn to Mayo Clinic's website looking for information on a plethora of concerns. Mayo Clinic data analysts did a little digging to find your top queries and questions of 2017.
Dr. Sandhya Pruthi has dedicated her career to breast cancer research and patient care. She also is the chief medical editor of Mayo Clinic's website.
Journalists: A broadcast-quality video (1:00) is in the downloads. Read the script.
In 2017, more than 350 million online visitors stopped by mayoclinic.org and did nearly 18 million health-related searches.
"We really rely on our medical experts who provide the review of the content because you don't want to get misleading or inaccurate information," says Dr. Pruthi. "And mayoclinic.org is one of the No. 1 rated websites for health information."
What were some of the most popular health-related searches? Diabetes earns the No. 1 spot as the most searched on Mayo Clinic's website.
"Here are the top five search terms of 2017: 1. Diabetes, 2. Lupus, 3. Fibromyalgia, 4. Pneumonia and 5. Hypertension," says Dr. Pruthi.
And what medical questions were most searched?
"How to lower blood pressure," says Dr. Pruthi. "How to lower cholesterol? What is normal blood pressure? Is shingles contagious? How much water should you drink?"
Dr. Pruthi says it's important to get online information from a trusted source.
"Where you can get good information, but information that's also easy to understand."
#chief medical editor
#Dr. Sandhya Pruthi
#Mayo Clinic Minute
#medical terms
New guideline: Try exercise to improve memory, thinking
Mayo Clinic Radio: Pediatric asthma and allergies
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mm203: One Laptop Per Child — News, and a discouraging word
One of this nanocorner of the ‘Sphere©‘s favorite topics for the past few months, the One Laptop Per Child initiative of Nicolas Negroponte and his non-proft spin-off from MIT, is back in the news today. Here are many of our previous posts:
mm088: Meet the XO
mm089: Amateur mapmaking…
mm099: A $99 Desktop…
mm149: India’s take…
mm153: By a Laptop, Get one…
mm162: Laptop with a Mission
mm170: Technology and Ed …
mm179: OLPC for India after all?
mm189: OLPC cranks up!
Today, the “Give One, Get One” “civilian” donation program has been extended.
By RODRIQUE NGOWI | The Associated Press
12:10 AM CST, November 23, 2007
CAMBRIDGE, Mass. (AP) — A promotion in which a customer buying a $188 computer in the U.S. and Canada automatically donates a second one to a child in a developing country was extended until year’s end, organizers said Thursday.
The “Give One, Get One” program will now run through Dec. 31, instead of ending on Nov. 26, according to the One Laptop Per Child Program, a nonprofit spinoff from Massachusetts Institute of Technology.
Always felt that two weeks was artificially short — after all the end of year gift/donation period lasts all the way to the end of the year.
[Please click the link below for the complete article — but then please come on back!]
One Laptop Per Child extends promotion until year’s end — chicagotribune.com
Of course, Newton’s law makes mandatory an equal and opposite reaction to the mostly positive news generated by this program.
From a site not before encountered comes the following two recent curmudgeonly observations, and we always make room for a fellow contrarian:
from the soft-bigotry-of-low-expectations dept
The One-Laptop-per-Child project, which the press is still referring to as the “$100 laptop” despite the fact that it now costs twice that, finally began rolling off the assembly line this week. What’s most striking about the effort is how dramatically Nicholas Negroponte has had to scale back his formerly lofty ambitions to get the project off the ground. He initially said that they’d need 3 million orders before they started production.
Techdirt: Dramatically Scaled-Back OLPC Begins Production
from the isn’t-technology-supposed-to-get-cheaper? dept
I’ll admit it. I’ve never quite understood the rationale behind the $100 laptop (or OLPC or whatever it’s being called these days). Yes, it’s a noble goal to get technology into the hands of people around the world with the hope that they can do something productive with it — but a big top down attempt to build something without much actual user feedback seems destined to fail.
Techdirt: Price Of The $100 Laptop Going In The Wrong Direction
Many a time, lofty goals founder on the shoals of the real world. Okay, $100 became $188, but one wonders what exactly has happened to the dollar itself in the several years since this project was born.
We know what happened to the dollar: it has lost much ground vs. the rest of the world, thanks to our kill-taxes-but-spend-stupendously administration of George III. One might imagine that had the project been denominated in Euros that its final cost might well have stayed closer to its initial target. So that feels like petty and carping argument.
MUDGE is still prepared to give OLPC the benefit of the doubt — the lofty goals thing deserves at least that.
And as we’ve been suggesting in this space,
I would think that people who would find a $399 purchase with a 50% charitable component affordable might also wish, as the story suggests, to donate the PC they’re entitled to a (not third world, but certainly third rate) school in this country.
God knows that there are pockets of the third world within these preciously regarded borders of ours, many within our biggest cities. Then it becomes a $399 charitable contribution, serving to further education among the deserving needy in our own country as well as beyond.
If this promotion serves to prime the production pump, so as to assure economic deliveries to the nations like Peru and Mexico and Italy (for Ethiopia — now that’s fitting!) that have committed to the project, then it’s absolutely worthwhile.
As the giving season is well upon us, why not add OLPC’s “Give 1, Get 1″ to your planning (orders to be taken Nov. 12–26); and as MUDGE recommends, just make that slight adjustment and you can call it “Give 1 (there), Give 1 (here).”
It’s it for now. Thanks,
Technorati Tags: One Laptop Per Child, OLPC, XO, Give One Get One, technology, geopolitics, Nicholas Negroponte
4 Comments | Geopolitics, musings, Technology | Tagged: Geopolitics, Give One Get One, Nicholas Negroponte, OLPC, One Laptop Per Child, Technology, XO | Permalink
You are currently browsing the Left-handed Complement blog archives for the day Friday, November 23rd, 2007.
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Two decades of MUSC research suggest that an over-the-counter antioxidant could help those recovering from addiction avoid relapse by controlling intrusive thoughts
By Tonisha Kearney-Ramos, Ph.D. and Nouhou Ibrahim, Ph.D.
Illustration by Emma Vought
Addiction robs its victims of free will, leaving compulsion in its place. Peter W. Kalivas, Ph.D., chair of the Department of Neuroscience (Research) at the Medical University of South Carolina (MUSC), has spent two decades elucidating the biological mechanisms underlying that compulsion and identifying a means to restore choice.
The answer could come in the form of an inexpensive, over-the-counter oral antioxidant called N-acetyl-cysteine (NAC), which he has shown in preclinical models to help prevent reinstatement of drug seeking by acting on a pathway whose importance in addiction he helped identify. Excitement over his findings has led to studies worldwide to test NAC’s efficacy in a wide variety of addictions and compulsive disorders.
Clinical investigators at MUSC have worked closely with Kalivas to show NAC’s potential for treating adolescent marijuana and alcohol abuse, smoking, cocaine addiction and for substance use that is comorbid with other compulsive disorders, such as post-traumatic stress disorder (PTSD). Collectively, their findings suggest that NAC, while not capable of causing an active user to cease taking drugs, can help those who are abstinent remain sober by reducing the intensity and frequency of intrusive, drug-seeking thoughts.
“NAC doesn’t cure addiction,” says Kalivas. “People still require therapy and have to relearn their life if they have been an addict for twenty years. But this drug will make it easier for them to relearn their life without drugs.”
Their work could one day lead to an inexpensive and easily administered adjunct therapy to low-intensity psychosocial treatments for addiction. With its low cost and good side effect profile at therapeutic doses, NAC should translate easily to the primary care clinic, where it can benefit the most people.
But none of this would have been possible without decades of patient and tenacious basic science research to elucidate the underlying mechanisms of drug addiction and identify a drug target.
Hijacking the brain’s reward system
The neurotransmitter dopamine is the primary currency of the brain’s reward system. An action that elicits an increase in dopamine is experienced as pleasurable. The brain “learns” to associate that action with reward. The pleasurable experience of natural rewards such as food and sex are signaled through dopamine release in the reward system as a way to ensure continued pursuit of actions that enable survival.
Drugs of abuse, however, put the reward system into overdrive by eliciting unnaturally high increases in dopamine release. As a result, the brain “overlearns” the association between taking the drug and reward. As that association is strengthened through continued drug use, it becomes increasingly difficult for the user to think of anything other than the drug.
Yet, while dopamine drives formation of the drug-reward associations, decades of research by Kalivas have shown that another neurotransmitter, glutamate, is also implicated in drug addiction. Typically, glutamate would be released in the synapse in response to cues that signal reward but would then be cleared by a glutamate transporter (GLT-1) — a protein that regulates glutamate signaling.1 This balanced release and clearance of glutamate facilitates the brain’s ability to fine-tune and adapt learned behaviors in response to environmental stimuli.
Kalivas has shown reduced numbers of GLT-1 transporters in animals using addictive drugs. As a result, the released glutamate is not cleared from the synapse and instead “spills over” into the extrasynaptic space, activating glutamate receptors in a broader area.
This spillover and broader activation of glutamate receptors cause the brain to attribute greater weight to actions related to drug use, thereby reducing the user’s willpower — the ability to choose other actions in the face of intrusive drug-related thoughts. Continued dominance of drug-related thoughts and actions precipitates the compulsive drug-seeking and use behaviors that characterize drug addiction.
Kalivas illustrates this hijacking of the brain by drug-related thoughts with an anecdote:
I’m at work and my wife calls me and says ‘Remember, I have to be out tonight, you’ve got to be home to cook dinner and help your daughter with homework.’ So, I’m driving home, then I get a call from a buddy who’s just arrived in town and everybody’s meeting up at my favorite bar downtown. Now I’ve got two things, my wife’s phone call and the phone call from my friend. So, what am I going to do? If I’m an addict, what happens is you’ve got these two competing plans, and pretty soon all I’m thinking about is that drinking plan, and the plan with my kids fades into the background. What we have been figuring out is how the drinking plan becomes the dominant, prepotent plan and causes the person to make the wrong choice — something that can be seen as a lack of willpower.
Target practice — Homing in on the NAC mechanism
The observation that the glutamate system was dysregulated in addiction sparked two decades of research by Kalivas. In a 1996 study published in the Journal of Neuroscience, Kalivas’ laboratory showed that repeated cocaine administration in rodents produced sustained effects on glutamate release in the reward system, which resulted in glutamate spillover at the synapse. These findings — the first clear indication of drug-mediated glutamate dysregulation of the reward system — identified the glutamate system as a potential therapeutic target.1
Kalivas and colleagues next pursued the source of the glutamate spillover. In 2002, they published a study revealing the involvement of the cystine/glutamate exchanger, a protein known to play a role in regulating extracellular glutamate levels. They showed that withdrawal from repeated cocaine administration resulted in down-regulated cystine/glutamate exchangers, significantly altering extracellular glutamate levels.2
This led them to hypothesize that targeting the cystine/glutamate exchanger using NAC, a cystine precursor, might be a potential way to rebalance glutamate homeostasis — the balance between glutamate release and clearance — that is disrupted in addiction.
In 2003, Kalivas and colleagues published a study showing that restoration of cystine/glutamate exchange by NAC normalized the levels of glutamate in cocaine-treated rodents. On a behavioral level, reinstatement of drug seeking — the preclinical model of relapse — was prevented by stimulating cystine/glutamate exchange with NAC and restoring extracellular glutamate levels. This study demonstrated that it was possible to therapeutically alter the glutamate system and see a difference in addictive behavior.3
However, later work by Kalivas revealed that they may have been aiming at the wrong target. An article published in 2010 showed that repeated cocaine use reduces GLT-1, another regulator of extracellular glutamate, and that NAC inhibits cocaine seeking through restoring GLT-1 activity.4
The identification of an alternative pathway led Kalivas and colleagues to be less certain about their previously proposed mechanism of action for NAC in cocaine use. As a result, in 2015, Kalivas conducted a preclinical study directly aimed at disentangling whether NAC inhibits reinstatement of cocaine seeking through the restoration of GLT-1 and/or the cystine/glutamate exchanger. This was tested by determining whether blocking the ability of NAC to restore one or the other protein would prevent the ability of NAC to inhibit cocaine seeking. Kalivas discovered that restoring GLT-1, but not the cystine/glutamate exchanger, is the key mechanism by which daily NAC administration reduces cocaine reinstatement.5
Through many years of dedicated research and persistence in the face of misidentified scientific targets, Kalivas was able to uncover the mechanisms critical to an understanding of how NAC works in the glutamate system.
Taking NAC to rehab
Kalivas’s groundbreaking work — which could only have been accomplished in preclinical models — paved the way for human clinical studies by researchers at MUSC and elsewhere that have brought NAC to the forefront as a promising new treatment for those addicted to a wide variety of substances as well as those afflicted with other complex psychiatric disorders.
In 2007, Kalivas and Robert J. Malcolm, M.D., professor of Psychiatry, Family Medicine and Pediatrics at MUSC, published the first two human clinical studies investigating NAC for treatment in substance abuse. These small pilot studies suggested early promise for NAC use in cocaine users by demonstrating that short-term NAC treatment could stop or reduce cocaine use, as well as cocaine craving.6,7
However, it was not until years later in 2013 that they published the first large-scale, double-blind, placebo-controlled clinical trial that truly enabled them to investigate the efficacy of NAC treatment in substance users. Cocaine-dependent participants (n = 111) were randomized to receive daily doses of 1,200 mg of NAC, 2,400 mg of NAC or placebo. Participants were followed for eight weeks, with urine samples collected and tested for cocaine use at periodic visits.8
Overall, the primary results for the clinical trial were negative — they did not find reduced cocaine use for NAC-treated vs. placebo-treated participants. However, when only the subset of participants who had achieved abstinence at trial entry was considered, results favored the 2,400 mg NAC group relative to placebo, with the 2,400 mg group showing longer times to relapse and lower craving ratings.
While the trial failed to demonstrate that NAC could reduce cocaine use in actively using cocaine-dependent individuals, this was evidence that it could prevent relapse in individuals who had already achieved abstinence from cocaine by reducing intrusive thoughts (craving) about drug use.
“If you can get someone abstinent from cocaine and then put them on NAC, that is where it seems to help them over a placebo — as a relapse preventive agent but not a curative agent,” Malcolm explains.
Marijuana use has spiked among adolescents, and yet current cessation programs, which rely primarily on psychosocial treatments, have yielded low rates of abstinence. Currently, there is no FDA-approved pharmacotherapy for marijuana use disorder.
Evidence that NAC could play a role in treating substance abuse led Kevin M. Gray, M.D., a professor in the Department of Psychiatry and Behavioral Sciences at MUSC, and colleagues to conduct the first double-blind, randomized controlled trial to assess NAC as a potential pharmacotherapy for marijuana dependence in adolescents. The results of the study were published in the August 2012 issue of the American Journal of Psychiatry.9
Led by Gray, the eight-week trial randomized marijuana-dependent adolescents (aged 15-21) to either 1200 mg of NAC or placebo twice daily, along with twice-weekly contingency management (i.e., abstinence and adherence were rewarded with small cash payments) and a weekly cessation counseling session lasting less than ten minutes.
At the trial’s end, participants receiving NAC were more than twice as likely to have negative urine cannabinoid tests as those in the placebo group (adjusted odds ratio: 2.4). In the NAC group, 41 percent of participants had a negative urine screen on the last day of treatment vs. 27 percent in the placebo group.
“This is the first fully powered trial of a pharmacological agent conducted in any age group to have a positive finding as an adjunct to psychosocial treatment, and it happened to be in kids,” adds Gray.
Enthusiasm over these results in adolescents led the National Institute of Drug Addiction to fund Gray to lead a randomized controlled trial in adults, the findings of which he reported in April 2016 at the American Society of Addiction Medicine’s annual conference in Baltimore, MD. Unlike the adolescent trial, the six-site, 12-week trial, which enrolled 302 adults, showed that the NAC group was no more likely than the placebo group to have negative urine cannabinoid tests (unpublished data; manuscript under review).
“The effects of NAC did not seem to translate from adolescents to adults, and so I put my thinking cap on to see what the differences might be,” says Gray. “A key is that quantitative urine cannabinoid levels and years of regular marijuana use at baseline were much higher in the adult than in the adolescent trial. The threshold to have a treatment effect was much higher to reach. Neurochemically, we might have been doing the same thing, but maybe it wasn’t quite enough.” Medication adherence was also poorer in adult patients.
Subgroup analysis of participants aged 18-21 in the multisite trial, however, suggested that those taking NAC were twice as likely to have a negative test as those in the placebo group, similar to the findings reported in the 2012 article.
The next step for Gray is to replicate the adolescent trial using low-intensity cessation counseling but without contingency management. The low-intensity counseling mirrors what would be widely available in primary care clinics where many adolescents seek care. If the findings are positive, NAC should be poised to translate easily into front-line care as an adjunct therapy for marijuana use disorder.
In a secondary analysis of the data obtained from the first adolescent marijuana trial, Lindsay M. Squeglia, Ph.D., an assistant professor in the Department of Psychiatry and Behavioral Sciences, and Gray showed that, instead of compensating for reduced marijuana use by drinking more, the NAC-treated group actually decreased its alcohol use as well.10 This is particularly compelling given the participants were not actively attempting to reduce their alcohol use, nor were they engaged in a combined behavioral treatment for alcohol use. These findings suggest NAC effects may generalize from marijuana to other substances and could be useful in decreasing adolescent alcohol use.
MUSC investigators interested in tapping NAC’s potential to develop new therapies for nicotine addiction, including Gray, Brett E. Froeliger, Ph.D., of the Department of Neuroscience, and Erin A. McClure, Ph.D., of the Department of Psychiatry and Behavioral Sciences, noted that the design of clinical trials of NAC did not always map onto preclinical findings. Preclinical studies conducted by Kalivas and others had shown NAC to be effective at preventing reinstatement of drug-seeking behavior after a period of extinction, and yet many NAC trials were focused instead on cessation in active users. The MUSC team hypothesized that NAC would be more effective if given to smokers who had achieved at least a brief abstinence.
In 2015, they published the results of a small proof-of-concept trial that randomized 16 non-treatment-seeking smokers, who were paid to remain abstinent, to NAC or placebo for 3.5 days.11 On day four, participants underwent functional MRI imaging. The NAC group reported less craving than the placebo group, and neuroimaging suggested that NAC positively affected the dysregulated corticostriatal connectivity characteristic of addiction.
This early evidence of NAC’s potential efficacy in abstinent smokers led the group to wonder if it could prove a powerful adjunct therapy for varenicline (VAR; Chantix®, Pfizer, New York, NY), the front-line pharmacotherapy for smoking cessation.
“Compared to all smoking cessation therapies, VAR is far and away the best, but the majority of smokers that use VAR still relapse,” says Froeliger. “It helps people quit (smoking) but does not do as good of job at keeping them off cigarettes.”
Since VAR and NAC use different mechanisms of action, the nicotine addiction research team at MUSC hypothesized that combining VAR, which acts on the cholinergic pathway to promote cessation, and NAC, which acts on the glutamate pathway to prevent relapse, could synergistically promote long-term abstinence at higher rates in smokers than either medication alone.
In 2015, they published the results of a pilot trial in 19 adult cigarette smokers that suggested the combination regimen was safe — most side effects were mild and in line with what would be expected of the individual agents — and well tolerated and that it was feasible to take it forward into clinical trial.12
The group then launched a clinical trial of the combination therapy in 2015 that will eventually enroll 100 smokers. Now in year two, the trial has already enrolled a quarter of those patients.
To ensure that clinical trial design is aligned with preclinical findings of efficacy and that preclinical studies are informed by real-world results, the project’s principal investigators include Kalivas, who will focus on understanding the neurobiological basis of NAC/VAR in a rodent model; Froeliger, a cognitive neuroscientist who will focus on imaging of human brains to explore whether NAC/VAR works on similar circuits in humans as in rodents; and Gray, who will lead the clinical trial. The ultimate goal is to compile the preliminary data needed to take the combination therapy forward into a much larger randomized clinical trial that would be powered to show efficacy and potentially gain FDA approval for a new smoking cessation approach.
PTSD with a comorbid substance use disorder
NAC may also have a role to play in the treatment of psychiatric disorders characterized by intrusive thoughts, such as PTSD, in which the glutamate pathway is dysregulated, as in addiction. Because NAC acts to restore balance to the glutamate system that is disrupted in both addiction and PTSD, researchers at MUSC hypothesized that it could potentially benefit patients with addiction and comorbid PTSD. Currently, there are no well-explored pharmacological treatments for patients with co-occurring addiction and PTSD, a particularly difficult-to-treat population.
Sudie E. Back, Ph.D., a professor in the Department of Psychiatry and Behavioral Sciences at MUSC and a staff psychologist at the Ralph H. Johnson VA Medical Center, randomized 35 veterans with an alcohol or drug use disorder and comorbid PTSD, all of whom were receiving group cognitive behavioral therapy (CBT) for their addiction, to either 2400 mg/day of NAC or placebo for eight weeks.11 To be included, veterans had to have abstained from substance use for at least seven days. This was the first randomized controlled trial of NAC as a pharmacotherapy for PTSD and a broad range of comorbid addictions.
NAC plus CBT reduced symptoms of PTSD, cravings and depression significantly more than CBT alone in these veterans. Veterans in the NAC-treated group showed a 46 percent reduction in scores on the Clinical-Administered PTSD Scale (CAPS), a gold-standard measure of PTSD symptoms, vs. a 25 percent reduction in the placebo group. The threshold CAPS score for diagnosis of PTSD is 50 and “as a group, the NAC-treated veterans were below diagnostic level for PTSD at the end of treatment,” says Back. “These are some of the best outcomes we have seen in the literature for a medication.”
The NAC-treated group saw greater decreases than the placebo group in craving (81 vs. 32 percent) and depression (48 vs. 15 percent). “Craving is a key component of substance use and relapse,” says Back. “If you have a medication that can really reduce craving, that will go a long way to helping people stay clean and sober.”
It is important to note that both groups received CBT and that NAC appears to work best in those who are at least briefly abstinent. As such, NAC should not be used as a monotherapy or substitute for evidence-based behavioral treatment but instead be seen as a medication that can be added to therapy to help patients with addiction and PTSD attain positive outcomes.
The positive results seen in the pilot study of NAC among veterans with PTSD and addiction led the Department of Defense and the National Institute on Alcohol Abuse and Alcoholism to fund Back, Gray, Kalivas and colleagues at MUSC to conduct two larger-scale, randomized controlled trials in veterans and civilians with alcohol use disorders and PTSD. Both projects were initiated in 2016 and are currently enrolling participants.
Can we cure addiction?
Two decades of preclinical research with NAC is coming to clinical fruition. Collectively, these trials suggest that adding NAC to standard-of-care psychosocial therapies could help prevent relapse in those who have achieved at least short-term abstinence from a variety of addictive substances. And yet, NAC is far from a cure for addiction.
“To think that we will cure drug addiction tomorrow is to say we will get in a space shuttle and colonize the moons of Saturn. We can conceive it, we can almost taste it, we can see how we could get in orbit and maybe do it. But it’s really quite a long way away — probably decades away,” explains Kalivas. “And that’s where we are with the brain. We have to understand how the brain works to develop the really precise interventions that will cure psychiatric disorders. For the brain, that’s 20 billion cells and 100 trillion connections. That will take time, and we will just never get there without preclinical research.”
1 Pierce RC, et al. J Neurosci 1996;15:1550-1560.
2 Baker DA, et al. J Neurosci 2002;22:9134-9141.
3 Baker DA, et al. Nat Neurosci 2003;6(7):743-749.
4 Knackstedt LA, et al. Biol Psychiatry 2010;67(1):81-84.
5 Reissner KJ, et al. Addict Biol 2015;20(2):316-323.
6 Mardikian PN, et al. Prog Neuropsychopharmacol Biol Psychiatry 2007;31(2):389-394.
7 LaRowe SD, et al. Am J Psychiatry 2007;164(7):1115-1117.
8 LaRowe SD, et al. Am J Addict 2013;22(5):443-452.
9 Gray KM, et al. Am J Psychiatry 2012 Aug;169(8):805-812.
10 Squeglia LM, et al. Addict Behav 2016 Dec;63:172-177.
11 Froeliger B, et al. Drug Alcohol Depend 2015;156:234-242.
12 McClure EA, et al. Am J Drug Alcohol Abuse 2015 Jan;41(1):52-56.
13 Back SE, et al. J Clin Psychiatry 2016 Nov;77(11):e1439-e1446.
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Trump Shocks The World With Support Of Putin, Even Conservatives Are Outraged
POSTED BY WLAS July 18th, 2018 0 COMMENTS
HELSINKI (AP) — In an extraordinary embrace of a longtime U.S. enemy, President Donald Trump on Monday openly questioned his own intelligence agencies’ firm finding that Russia meddled in the 2016 U.S. election to his benefit, seeming to accept Russian President Vladimir Putin’s insistence that Moscow’s hands were clean.
The reaction back home was immediate and visceral, among fellow Republicans as well as usual Trump critics. “Shameful,” ”disgraceful,” ”weak,” were a few of the comments. Makes the U.S. “look like a pushover,” said GOP Sen. Bob Corker of Tennessee.
If you’re an #American who
didn’t get mad when #Trump
blasted #NFL players for
kneeling OR put
#BorderChildren in cages,
maybe now that he’s sided
with #Russia over his own
country, you’ll see why the
rest of us have been
outraged all along.
#ImpeachTrump #Treason
#TeamDl
— DL Hughley
(@RealDLHughley) July 17,
Trump’s meeting with Putin in Helsinki was his first time sharing the international stage with a man he has described as an important U.S. competitor — but whom he has also praised a strong, effective leader.
His remarks, siding with a foe on foreign soil over his own government, was a stark illustration of Trump’s willingness to upend decades of U.S. foreign policy and rattle Western allies in service of his political concerns. A wary and robust stance toward Russia has been a bedrock of his party’s world view. But Trump made clear he feels that any firm acknowledgement of Russia’s involvement would undermine the legitimacy of his election.
The only way the base will
ever #ImpeachTrump is if
they catch him wearing a
“Black Lives Matter” t-shirt.
#treason
— John Fugelsang
(@JohnFugelsang) July 16,
Standing alongside Putin, Trump steered clear of any confrontation with the Russian, going so far as to question American intelligence and last week’s federal indictments that accused 12 Russians of hacking into Democratic email accounts to hurt Hillary Clinton in 2016.
“I have great confidence in my intelligence people, but I will tell you that President Putin was extremely strong and powerful in his denial today.
“He just said it’s not Russia. I will say this: I don’t see any reason why it would be,” Trump said.
His skepticism drew a quick formal statement — almost a rebuttal — from Trump’s director of national Intelligence, Dan Coats.
“We have been clear in our assessments of Russian meddling in the 2016 election and their ongoing, pervasive efforts to undermine our democracy, and we will continue to provide unvarnished and objective intelligence in support of our national security,” Coats said.
I think this is the most
important clip you can
watch today.
One of the most
conservative men in media,
Neil Cavuto, on Fox News,
said what Donald Trump did
today alongside Putin was
absolutely “disgusting.”
It’s the clearest rebuke from
a staunch conservative
you’ll see.
pic.twitter.com/yT2j6FP7Kb
— Shaun King
(@ShaunKing) July 16, 2018
Fellow GOP politicians have generally stuck with Trump during a year and a half of turmoil, but he was assailed as seldom before as he returned home Monday night from what he had hoped would by a proud summit with Putin.
Sen. John McCain of Arizona was most outspoken, declaring that Trump made a “conscious choice to defend a tyrant” and achieved “one of the most disgraceful performances by an American president in memory.” House Speaker Paul Ryan, who rarely criticizes Trump, stressed there was “no question” that Russia had interfered.
During an interview with Fox
News’ Chris Wallace, an
aggravated Putin refused to
acknowledge the Mueller
indictment and insisted
that Russia doesn’t “have
anything” on Trump
https://t.co/3tWMLL4wF4
— The Daily Beast
(@thedailybeast) July 16,
Even staunch Trump backer Newt Gingrich, the former House speaker, called Trump’s comments “the most serious mistake of his presidency” and said they “must be corrected — immediately.”
Former CIA Director John Brennan, who served under President Barack Obama, called Trump’s words “nothing short of treasonous.” Brennan tweeted: “Not only were Trump’s comments imbecilic, he is wholly in the pocket of Putin. Republican Patriots: Where are you???”
In a Fox News Channel interview after the summit, Putin pronounced the meetings “the beginning of the path” back from the West’s past efforts to isolate Russia. “I think you see for yourself that these efforts failed, and they were never bound to succeed,” he said.
As he flew home to Washington aboard Air Force One, Trump tried to clarify his position via tweet, saying: “As I said today and many times before, ‘I have GREAT confidence in MY intelligence people.’ However, I also recognize that in order to build a brighter future, we cannot exclusively focus on the past – as the world’s two largest nuclear powers, we must get along!”
In an interview with Fox News’ Sean Hannity that aired later Monday, Trump said “it’s a shame” that he and Putin were being asked questions about the Russia probe while they were trying to discuss issues like Syria and nuclear proliferation. “We’ve had a phony witch hunt deal drive us apart,” he said.
In their totality, Trump’s remarks amounted to an unprecedented embrace of a man who for years has been isolated by the U.S. and Western allies for actions in Ukraine, Syria and beyond. And it came at the end of an extraordinary trip to Europe in which Trump had already berated allies, questioned the value of the NATO alliance and demeaned leaders including Germany’s Angela Merkel and Britain’s Theresa May.
The two leaders’ long-awaited summit began with a private face-to-face sitdown — just the leaders and their interpreters — that lasted more than two hours, before additional meetings joined by senior aides.
The pair had held lengthy talks before — on the sidelines of world leader meetings in Germany and Vietnam last year — but this was their first official summit and was being watched closely, especially following the announcement Friday of new indictments against 12 Russian intelligence officers accused of hacking Democratic emails to help Trump’s campaign.
Asked about the indictments, Putin suggested that Moscow and Washington could jointly conduct the investigation, inviting special counsel Robert Mueller’s investigators to come to Russia to interview the 12 people — an idea Trump hailed as an “incredible offer.”
Putin said he’d expect the U.S. to return the favor and cooperate in the Russian probe against William Browder, a British investor charged with financial crimes in Russia. Browder, an outspoken Putin critic, was a driving force behind a U.S. law targeting Russian officials over human rights abuses.
The summit began just hours after Trump blamed the United States — and not Russian election meddling or its annexation of Crimea — for a low-point in U.S.-Russia relations.
“Our relationship with Russia has NEVER been worse,” Trump tweeted Monday morning, blaming “many years of U.S. foolishness and stupidity and now, the Rigged Witch Hunt!”
The Russian foreign ministry responded by liking Trump’s tweet and then replying, “We agree.”
Asked whether Russia was responsible at all, Trump said “we’re all to blame” for the soured relations.
However, “that changed,” he said, “as of about four hours ago.”
Putin ridiculed as “sheer nonsense” allegations that Russian intelligence agencies had collected compromising information on Trump during his visit to Moscow years before the election, saying that he had no idea Trump was even visiting.
Trump also dismissed the idea in his interview with Hannity, adding, “If they had it, it would have been out.”
Still, Putin said he had indeed wanted Trump to win the election — a revelation that might have made more headlines if not for Trump’s performance — but had taken no action to make it happen.
“Yes, I wanted him to win because he spoke of normalization of Russian-U.S. ties,” Putin said. “Isn’t it natural to feel sympathy to a person who wanted to develop relations with our country? It’s normal.”
At the closing press conference, Putin, riding high after hosting a successful World Cup, unveiled a gift he’d brought for Trump: a red and white soccer ball, which he tossed to Trump at the neighboring lectern. Trump passed it over to his wife, and said they’d give it to their soccer-loving 12-year-old son, Barron.
Out on the streets, the summit attracted a grab-bag of protesters, with abortion-rights activists wearing artificially bulging bellies and Trump masks, anti-fascist protesters bearing signs with expletive-laden insults, and free traders, anti-war Ukrainians and gay rights supporters making their voices hear.
Associated Press writers Zeke Miller, Ken Thomas and Darlene Superville in Washington contributed to this report.
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D1002 Well-Known Member
RalphW said: ↑
Aren't you thinking of the combine harvester lot.
No, it’s Slade.
They had a load of hits which were deliberately misspelled:
Coz I Luv You.
Mama Weer All Crazee Now.
Cum On Feel The Noize.
Gudbuy T' Jane.
My videos (D1002 Western Explorer) on YouTube
http://www.youtube.com/user/TheWesternExplorer?feature=mhee
D1002, Sep 9, 2019
RalphW Part of the furniture Staff Member Administrator Friend
Retired-ish, Part time rail tour steward.
D1002 said: ↑
Of course, it was the Worzels with the 'new combine harvester'.
Videos at http://www.youtube.com/profile_videos?user=ralph5407
RalphW, Sep 10, 2019
3ABescot New Member
Yome roit. Noddy 'Older wuz from Worsull, loik me.
3ABescot, Sep 10, 2019
Will the Duchess make it for Sunday's Royal Duchy or will No.9 substitute?
Sam 60103, Sep 10, 2019
1020 Shireman Well-Known Member Friend
Relaxingly retired
Deep in the country
Contacted RTC. PRCLT confident repairs will be completed for 6233 to move to Southall on Friday.
1020 Shireman, Sep 10, 2019
lil Bear likes this.
Changes to the Tynesider now 14th December Christmas White Rose approx. timings:
Station Outward Return
London King’s Cross 07:23 22:10
Stevenage 08:12 21:24
Peterborough 09:36 19:30
Paul42 likes this.
Kylchap Member
1020 Shireman said: ↑
What's the odds on this being steam only, or assisted? Any inside knowledge? I asked RTC a couple of months ago and they said to contact them the week before the trip.
Kylchap, Sep 13, 2019
Kylchap said: ↑
The big question. There's no need for a tailgunner with such a long layover at York and I've had no indication there will be from my contacts; but the week before the train is way too late for that info. to come out.
Any word on the loco for Saturday's Blackpool job?
Britfoamer, Sep 19, 2019
Paul42 Member
45690 Leander from a couple of emails from RTC and their website.
My Photos of Uk Steam on the Mainline and Preserved Railways, and European Steam can be found at http://paulsimpson.zenfolio.com/ and https://www.flickr.com/photos/163722354@N06/ .
Paul42, Sep 19, 2019
Britfoamer likes this.
Bulleid Pacific Member
A Thingy...
The South Yorkshireman has acquired an extra 5MT, according to a redrafted RTC write-up:
https://www.railwaytouring.net/uk-day-trips/south-yorkshireman
Where there's a rail, there's a way...
"I'm taking an early holiday 'cos I know summer comes soonest in the south"...
because...
"The sun shines most on the Southern coast"
Bulleid Pacific, Oct 13, 2019
Oswald T Wistle, lil Bear, iancawthorne and 1 other person like this.
John Petley Well-Known Member
Researcher/writer and composer of classical music
Between LBSCR 221 and LBSCR 227
Bulleid Pacific said: ↑
The South Yorkshireman has acquired an extra 5MT, according to a redrafted RTC write-up.....
But RTC hasn't yet seen fit to change the page for the "Sussex Belle". I would be absolutely delighted to see No. 60009 on the main line only a few miles from my home and would happily be put up with being called cynical, over-sceptical or whatever if my favourite LNER loco does indeed work this train, but while I think it could probably make it as far as Eastbourne. I'm afraid I remain very unconvinced about its chances of working the return leg via the restricted clearances of the Hastings line via Battle and Tunbridge Wells. The web page does say "Or a Black Five" after mentioning Number Nine and this is what I am expecting. Considering how rare steam is in this neck of the woods, no complaints if I am correct. I would be more than happy if 44871 pays its second visit of the year to the Sussex Coast, but the photo on the web page shows 60009. The only way I could see this being possible is for the train to run steam to Brighton, diesel to Eastbourne and then back with steam to London via Plumpton. Still, all will be revealed in due course, no doubt.
John Petley, Oct 14, 2019
John Petley said: ↑
But RTC hasn't yet seen fit to change the page for the "Sussex Belle". I would be absolutely delighted to see No. 60009 on the main line only a few miles from my home and would happily be put up with being called cynical, over-sceptical or whatever if my favourite LNER loco does indeed work this train, but while I think it could probably make it as far as Eastbourne. I'm afraid I remain very unconvinced about its chances of working the return leg via the restricted clearances of the Hastings line via Battle and Tunbridge Wells. The web page does say "Or a Black Five" after mentioning Number Nine and this is what I am expecting. Considering how rare steam is in this neck of the woods, no complaints if I am correct. I would be more than happy if 44871 pays its second visit of the year to the Sussex Coast, but the photo on the web page shows 60009. The only way I could see this being possible is for the train to run steam to Brighton, diesel to Eastbourne and then back with steam to London via Plumpton. E Still, all will be revealed in due course, no doubt.
Some years ago SD tried to run a trip with Bittern from Lewes to Ely, and due to gauging, Britannia hauled the train instead.
Paul42, Oct 14, 2019
TheModster New Member
Duchess seen on todays "The Yorkshireman" tour at Mill Hill Broadway, wearing an extra headboard in memory of Nigel Dobbing, one year on from his passing:
TheModster, Oct 19, 2019
Timings for the trip
https://www.realtimetrains.co.uk/train/U10995/2019-11-08/detailed
Gladiator 5076, Oct 29, 2019
Paul42 said: ↑
No surprise - it won't be 60009 working down to Eastbourne later this month. We gauging cynics has been vindicated! See here. Once again, it's a Black Five to the rescue and the website specifically says 45407. Much as I like 44871 and 45212, in recent times 45407 has been a much less frequent solo visitor to the South of England than the other two Black Fives under the ownership or custodianship if Ian Riley. A train from Three Bridges to Bath in March 2017 is the only 45407-hauled working I can think of in the last five years apart from a few occasions when it has double-headed with 44871.
John Petley, Nov 5, 2019
Depends on your definition of the South John. It did Bristol to Poole on 26/11/15 the outbound leg being diesel. It replaced Tangmere, and was not down in time to do the tour in both directions.
Gladiator 5076, Nov 5, 2019
Gladiator 5076 said: ↑
I stand corrected! I must have forgotten about this one.
Dan Hill New Member
Brick Machine Operator
I noted this just now as I was looking through. Am I right to assume its the Keymer Junction onwards section of the tour that is causing the gauging issues with 60009, as 60019 has run down the Brighton Line twice in 2008 and 2009 when in BR livery but didn't haul the SD tour from Lewes in 2011 due to gauging when the loco was fitted with valancing.
Having missed out on 6233 both on the SD Sheffield Park to Bath trip and Giants of Steam at the Bluebell I've decided to book up the Lindum Fayre trip on December 7th and I'm considering the White Rose the following week to get a mainline run behind 60163 for the first time and a probable final run formyself behind 60009.
Dan Hill, Nov 5, 2019
Dan Hill said: ↑
I have also been behind 60019 down the Brighton Main Line so the gauging issues as far as the run down to Eastbourne are concerned must be east of Keymer Junction. Lewes Station, with its sharp curve, is one likely spot although it could be some minor farm overbridge. Only someone with access to the gauging profile is likely to be able to give chapter and verse.
More to the point is the Tonbridge-Hastings line, notorious for tight clearances since the dodgy contractors' skimping of the brick lining in Wadhurst Tunnel came to light soon after the line was built. Somerhill, Grove, Wadhurst and Mountfield Tunnels were all singled as part of the electrification work in the 1980s, but I think that some of the tunnels which weren't singled are still a bit on the tight side. Furthermore, most of the rest of the former SE&CR network (apart from Reading-Redhill) is rather restricted. Tornado and Blue Peter have both run to Canterbury, but I gather that one bridge in the Bromley/Bickley area is very narrow indeed. No other non-Southern 8Ps will fit, regrettably, and no non-Southern 7Ps apart from Brits.
Dan Hill likes this.
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Ridden behind both 3985 and 844 on the Denver Post Cheyenne Railroad and Rodeo train, hope this devil ends up on that train either next year or shortly thereafter!
I'm green with ènvy.
osprey, May 7, 2019
The paper has stopped doing them with effect this year, was announced 6-8 weeks ago.
guycarr360, May 7, 2019
Not really having to work hard, but look at the crowds - Flying Scotsman, eat your heart out!
Jamessquared, May 7, 2019
30854, green five, Kinghambranch and 3 others like this.
Thank's for that, makes all the hard work worthwhile..wish I could have got over to see it.
Now imagine the apoplectic froth that would be generated if enthusiasts in this country were standing in similar positions to our American friends. Interesting how cultures develop and diverge.
Enterprise, May 8, 2019
7P6F Member
Wot no fences!!! How many casualties that day! Was it carnage on the lineside??!!
7P6F, May 8, 2019
7P6F said: ↑
Looking back at my pictures from the 60s I would say over half were taken from a trespass position but officialdom had a much more tolerant view of the serious enthusiast back then. One incident comes to mind when a small group of us, including an off duty fireman were attempting to clean up MN 35007 with paraffin soaked rags, totally illegal of course. The running foreman came round and asked how we were going to do the tender, something we hadn’t thought of. He returned a few minutes later with a ladder! I did get some odd likes on the train going home, I must have reeked of paraffin. Somehow we all survived.
Johnb, May 8, 2019
The Dainton Banker likes this.
Yeah and those Americans even managed to avoid standing in places where they might be hit, I assume that the test runs were not publicised in the media then
She's a big bugger, isn't she. Impressive piece of kit, gonna be a bugger to get a rods down picture of like so many crave!
GWR4707, May 8, 2019
Greenway Part of the furniture
The Deep South
It has been interesting to follow the progress by UP in getting these steam giants back into operational service.
I only wish I had the money to buy the model for my garden railway. I am happy as it would not not look to well with my other USA models.
Greenway, May 8, 2019
Yeah and those Americans even managed to avoid standing in places where they might be hit
Sadly, less than a year ago, a woman taking photos of 844 on her phone whilst standing on the sleeper ends was killed outright when the loco's pilot beam hit her.
marshall5, May 8, 2019
For those with FB, here are details of the live streaming for the event, for those without.....
Hello Steam Fans! The big #Transcon150 Celebration Event featuring the meet between #UP844 and Big Boy #UP4014 is tomorrow (Thursday) at 10:30 a.m. MT at Ogden Union Station. Those attending can find all of the event details, including links to parking information, at https://www.up.com/heritage/steam-meet/index.htm. We will begin live streaming the ceremony via the Union Pacific Facebook page at 10 a.m. MT. Make sure to "Like" Union Pacific Railroad on Facebook to be notified when we go live!
up.com
Union Pacific's Transcontinental Railroad Completion Celebration
Union Pacific is the largest railroad in North America, covering 23 states across the western two-thirds of the United States
keith6233 and 30854 like this.
That's goosed that then, need to explore other options!
Britfoamer, May 14, 2019
Union Pacific Steam Club Update No. 8 - June 13, 2019
The Big Boy No. 4014 is headed back out on the Union Pacific system beginning July 8 for a tour, taking it through Illinois, Iowa, Minnesota, Nebraska, Wisconsin and Wyoming.
Called the Great Race Across the Midwest, the tour will include displays at the following locations:
July 13-14: Omaha, Neb. (paid admission required through Railroad Days)
July 18: St. Paul, Minn.
July 20: Duluth, Minn.
July 23: Altoona, Wis.
July 27-29: Chicago, Ill.
Aug. 1: Des Moines, Iowa
Aug. 3: Omaha, Neb.
Aug. 6: North Platte, Neb.
The full schedule and route map are online in the Steam section of UP.com.
You can follow No. 4014 as it makes its way across the system via our Steam Locomotive Tracking map, which traces No. 4014's location using GPS. The location is continuously updated when the train is on the move.
You also can track the Big Boy via the @UP_Steam Twitter page at http://twitter.com/up_steam. The account tweets the train's location as it changes.
Find both the tracking map and Twitter feed, along with steam schedule information, at upsteam.com.
The Experience the Union Pacific Rail Car, a new, multi-media walk-through exhibition providing a glimpse at the past while telling the story of modern-day railroading, will accompany the Big Boy on this tour. Find out more.
UP Steam Club 36,500 Strong!
As of this mailing, there are now more than 36,500 members of the Union Pacific Steam Club, and that number keeps growing. Thanks again for joining the club!
With No. 4014 about to head out again, we have a favor to ask: As a Steam Club member and rail fan, you're more aware of the dangers associated with train operations than your typical neighbor who may be trackside for the first time. Because of your knowledge, we're asking you to have the courage to tell someone if what they're doing is unsafe – whether they're standing on or too close to the tracks, running along the ballast, leaving trip hazards in walkways or climbing on equipment.
You can help us and the UP steam program by spreading a message of safety or by reporting unsafe behavior.
Safety Reminder
Let's go over some basic safety information:
The average train overhangs the track by at least three feet and wider loads can extend even further from the tracks. Stand back at least 25 feet or more from the tracks to avoid debris and steam or being hit by the train itself.
Trains can't stop quickly to avoid people or vehicles on the tracks.
Railroad tracks, trestles, yards and right of way are private property – please do not trespass.
Never assume tracks are abandoned or inactive – ALWAYS expect a train and assume tracks are active.
Look both ways when approaching railroad crossings, and stop for trains. A train's distance from you -- and its speed -- can be deceiving.
Look twice at crossings with multiple tracks. Two tracks may mean two trains, so make sure all tracks are clear before crossing each rail line.
Avoid distractions including loud music, texting and talking on cell phones. Look up and listen for train horns.
When taking photos or video, be mindful of your surroundings. Make sure you're in a safe place or have someone "spot" you while you're looking through your camera's viewfinder. What you don't see could hurt you.
Looking Back at the 150 Celebration
We've created a new 150 Celebration webpage that includes some of our best photos and video from The Great Race to Ogden and the May 9 anniversary ceremony. Take a look.
In addition, Steam Club members who joined the Official Union Pacific Steam Club Facebook Group have contributed more than 8,600 photos, videos and stories since the page went live January 1. If you haven't joined the closed Facebook group yet, what are you waiting for? Just click this link and ask to become a member. Before joining in the discussion, take a moment to read our Facebook Policy.
That's all for now. Be safe, and we'll see you trackside,
Union Pacific Steam Club
guycarr360, Jun 13, 2019
Bluenosejohn likes this.
marshall5, Jun 13, 2019
Out and about again, follow the link above for whereabouts and journey details.
Also a new excursion has been announced, would expect a start in LA, a climb of the San Bernadinho pass would be something else...
Passengers to ride Southern California's only Big Boy excursion train.
Can you imagine the most famous steam locomotive returning to life after 60 years of retirement? The Railway and Locomotive Historical Society, Southern California Chapter, operator of RailGiants Train Museum, returned Big Boy No. 4014 to Union Pacific for that purpose. Recently, Big Boy No. 4014 began its second operational life.
Union Pacific Big Boy No. 4014 will soon return to Southern California to lead a special passenger excursion train, using Union Pacific's heritage passenger car fleet, as a fund-raiser to benefit RailGiants Train Museum and our organization.
Our journey will occur on October 12 & 13, 2019, and will be a rare lifetime experience behind the king of steam locomotives. Many details remain to be determined.
To help us plan and execute this railfan trip of a lifetime, join our 4014 Journeys List. To obtain information updates FIRST, provide us your email address so that we can send information to you as they are available. We may also seek your input regarding your wishes for the journey. We will not use your email address for any other purpose or disclose it to any other organization.
guycarr360, Jul 12, 2019
On the rails in Wisconsin:
https://www.youtube.com/watch?time_continue=4&v=ly5ogJfZcLw
Greenway, Jul 26, 2019
Sunnieboy and Bluenosejohn like this.
Greenway said: ↑
Thanks for that...
osprey, Jul 26, 2019
Time for a ride out to California I think
https://4014traintix.com/travel-details.html
Autotank New Member
Radio Producer/Presenter
Twyford, Berkshire
Blimey 700 bucks for the cheapest ticket - and I thought UK railtours were getting expensive! Having said that a trip across the pond to see 4014 in action is firmly on my list of things to do in the next 5 years.
Autotank, Aug 13, 2019
guycarr360 likes this.
Autotank said: ↑
The first trip it did was $5000 a ticket, up Cajon Pass should be incredible.
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Learn to shoot
Muzzle Loading is an NRA recognised discipline, this is to say that the NRA recognises the Muzzle Loading Association of Great Britain (MLAGB) as its National Governing Body.
Muzzle Loaders:
The MLAGB was formed in 1952 and is the governing body for muzzle loading within the UK. Its objectives are to encourage an interest in muzzle loading firearms; to promote, regulate and safeguard their use; and to preserve their freedom of collection.
MLAGB runs a number of events covering all aspects of muzzle loading arms. These broadly follow the history of firearms development from the early days of matchlock, through the flintlock era and right up to the late Victorian period when the percussion mechanism reached its zenith. Fine examples of rifles from this period are still regularly used.
Rifle and Musket Shooting – 50 metre
There are a number of events for rifles and muskets that are shot at 50 metres from the standing position. Off hand ‘Schuetzen’ style shooting with muzzle loading rifles is extremely popular in Europe and is a precision discipline with shooters regularly achieving near perfect scores. Smoothbore muskets in both matchlock and flintlock mechanisms are also shot at this distance, and are surprisingly accurate when correctly loaded.
Rifle Shooting – 100 to 1200 metres
Muzzle loading rifles are shot at distances from 100 through to 1200 metres. These are precision events, and both original and reproduction rifles are capable of superb shooting at all distances. The longer distances recreate the first rifle matches that were organized by the NRA and held at Wimbledon during the 1860s prior to the move to Bisley.
Pistol Shooting – 25 metres
Pistol shooting is generally carried out at 25 metres although there are some events held at 50 metres. There are a number of different categories including matchlocks, flintlocks, percussion single shot and revolvers. Matchlock and flintlock pistols are smoothbore, and like their longer barreled brethren, can be surprisingly accurate.
Miniature Cannon – 25 metres
The MLAGB also runs events for miniature cannon. This is a relatively new activity and is becoming extremely popular. Miniature cannon are generally smoothbore and despite the lack of sights can shoot extremely well.
The MLAGB holds regular competitions at Bisley as well as at its own range at Wedgnock in Warwickshire. In addition, the MLAGB is responsible for the UK muzzle loading international team. This has been extremely successful in recent years and currently lies in second place in world rankings, well ahead of a number of fully funded, sponsored countries.
The MLAGB runs courses to introduce muzzle loading shooting to newcomers to the sport. These courses cover all aspects of muzzle loading shooting from safe handling through to best practice as well as offering some hints and tips so that attendees can get the best out of their muzzle loader. (link to NRA Muzzle Loading courses)
The MLAGB today is a lively organization with members from all walks of life. Anyone interested in muzzle loading arms and would like more information is encouraged to visit the MLAGB web site.
Click here for details on Skills development courses
Paul Wolpe
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Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst
Shahab Mortezaei, Noelle R. Catarineu, James Canary
We provide proof-of-principle that an ambidextrous catalyst is capable of independent, dial-in control of the absolute stereochemistry of two similar nitrostyrene Michael addition reactions by in situ oxidation and reduction of the catalyst. The catalyst is capable of both static and dynamic catalysis modes; in combination both modes allow access to all four possible stereochemical outcomes for the two nitroalkane products in a single process.
Tetrahedron Letters
https://doi.org/10.1016/j.tetlet.2015.12.015
Published - Jan 27 2016
Instrument dials
Stereochemistry
Asymmetric catalysis
Helical inversion
Michael addition
Mortezaei, S., Catarineu, N. R., & Canary, J. (2016). Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst. Tetrahedron Letters, 57(4), 459-462. https://doi.org/10.1016/j.tetlet.2015.12.015
Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst. / Mortezaei, Shahab; Catarineu, Noelle R.; Canary, James.
In: Tetrahedron Letters, Vol. 57, No. 4, 27.01.2016, p. 459-462.
Mortezaei, S, Catarineu, NR & Canary, J 2016, 'Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst', Tetrahedron Letters, vol. 57, no. 4, pp. 459-462. https://doi.org/10.1016/j.tetlet.2015.12.015
Mortezaei S, Catarineu NR, Canary J. Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst. Tetrahedron Letters. 2016 Jan 27;57(4):459-462. https://doi.org/10.1016/j.tetlet.2015.12.015
Mortezaei, Shahab ; Catarineu, Noelle R. ; Canary, James. / Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst. In: Tetrahedron Letters. 2016 ; Vol. 57, No. 4. pp. 459-462.
@article{63905dd9ba5b4f6aaa94485f433a746c,
title = "Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst",
abstract = "We provide proof-of-principle that an ambidextrous catalyst is capable of independent, dial-in control of the absolute stereochemistry of two similar nitrostyrene Michael addition reactions by in situ oxidation and reduction of the catalyst. The catalyst is capable of both static and dynamic catalysis modes; in combination both modes allow access to all four possible stereochemical outcomes for the two nitroalkane products in a single process.",
keywords = "Ambidextrous, Asymmetric catalysis, Dynamic, Helical inversion, Michael addition",
author = "Shahab Mortezaei and Catarineu, {Noelle R.} and James Canary",
doi = "10.1016/j.tetlet.2015.12.015",
journal = "Tetrahedron Letters",
T1 - Dial-in selection of any of four stereochemical outcomes among two substrates by in situ stereo-reconfiguration of a single ambidextrous catalyst
AU - Mortezaei, Shahab
AU - Catarineu, Noelle R.
AU - Canary, James
N2 - We provide proof-of-principle that an ambidextrous catalyst is capable of independent, dial-in control of the absolute stereochemistry of two similar nitrostyrene Michael addition reactions by in situ oxidation and reduction of the catalyst. The catalyst is capable of both static and dynamic catalysis modes; in combination both modes allow access to all four possible stereochemical outcomes for the two nitroalkane products in a single process.
AB - We provide proof-of-principle that an ambidextrous catalyst is capable of independent, dial-in control of the absolute stereochemistry of two similar nitrostyrene Michael addition reactions by in situ oxidation and reduction of the catalyst. The catalyst is capable of both static and dynamic catalysis modes; in combination both modes allow access to all four possible stereochemical outcomes for the two nitroalkane products in a single process.
KW - Ambidextrous
KW - Asymmetric catalysis
KW - Dynamic
KW - Helical inversion
KW - Michael addition
U2 - 10.1016/j.tetlet.2015.12.015
DO - 10.1016/j.tetlet.2015.12.015
JO - Tetrahedron Letters
JF - Tetrahedron Letters
10.1016/j.tetlet.2015.12.015
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cc/2020-05/en_middle_0051.json.gz/line1618
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