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Click on the link above to find your favorite Bible version.
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http://www.biblegateway.com/versions/Amplified-Bible-AMP/
ANSWERS ARE BELOW THE QUIZ.
I used the King James version
Revelations 22
http://www.newbeginmin1.org/REVELATIONCHAPTER22.html
1-What was the river like, and what was on either side of it?
2-There will be no more curses, or evil, what will there be?
3-What did he say to John about His coming back?
4-What did the angel tell John to do with the sayings of the book?
5-What did Jesus send His angels to John for?
6-What do the people who testifieth to these things say?
Answers for Revelation 22
1- A pure river of water of life, clear as crystal, proceeding out of the throne of God and of the Lamb. In the midst of the street of it, and on either side of the river, was there the tree of life, which bare twelve manner of fruits, and yielded her fruit every month: and the leaves of the tree were for the healing of the nations.
2-the throne of God and of the Lamb shall be in it; and his servants shall serve him: And they shall see his face; and his name shall be in their foreheads. And there shall be no night there; and they need no candle, neither light of the sun; for the Lord God giveth them light: and they shall reign for ever and ever.
3-These sayings are faithful and true: and the Lord God of the holy prophets sent his angel to shew unto his servants the things which must shortly be done. Behold, I come quickly: blessed is he that keepeth the sayings of the prophecy of this book.
4-Seal not the sayings of the prophecy of this book: for the time is at hand. He that is unjust, let him be unjust still: and he which is filthy, let him be filthy still: and he that is righteous, let him be righteous still: and he that is holy, let him be holy still. And, behold, I come quickly; and my reward is with me, to give every man according as his work shall be. am Alpha and Omega, the beginning and the end, the first and the last. Blessed are they that do his commandments, that they may have right to the tree of life, and may enter in through the gates into the city. For without are dogs, and sorcerers, and whoremongers, and murderers, and idolaters, and whosoever loveth and maketh a lie.
5-I Jesus have sent mine angel to testify unto you these things in the churches. I am the root and the offspring of David, and the bright and morning star. And the Spirit and the bride say, Come. And let him that heareth say, Come. And let him that is athirst come. And whosoever will, let him take the water of life freely. For I testify unto every man that heareth the words of the prophecy of this book, If any man shall add unto these things, God shall add unto him the plagues that are written in this book: And if any man shall take away from the words of the book of this prophecy, God shall take away his part out of the book of life, and out of the holy city, and from the things which are written in this book.
6-He which testifieth these things saith, Surely I come quickly. Amen. EVEN SO, COME Lord Jesus.
The grace of our Lord Jesus Christ be with you all. Amen.
1-What did John see?
2-What did John hear from heaven?
3-What glorious thing is God going to do for us?
4-What did God tell John to write?
5-What happens to those who do not overcome?
6-What did the angel take John to see?
7-What was the temple in Jerusalem?
8-What will light the Holy City?
9-Will the gates ever be closed, and who will be allowed in?
1-I saw a new heaven and a new earth: for the first heaven and the first earth were passed away; and there was no more sea. And I John saw the holy city, new Jerusalem, coming down from God out of heaven, prepared as a bride adorned for her husband.
2-I heard a great voice out of heaven saying, Behold, the tabernacle of God is with men, and he will dwell with them, and they shall be his people, and God himself shall be with them, and be their God.
3-And God shall wipe away all tears from their eyes; and there shall be no more death, neither sorrow, nor crying, neither shall there be any more pain: for the former things are passed away.
4- Write: for these words are true and faithful. And he said unto me, It is done. I am Alpha and Omega, the beginning and the end. I will give unto him that is athirst of the fountain of the water of life freely. He that overcometh shall inherit all things; and I will be his God, and he shall be my son.
5-But the fearful, and unbelieving, and the abominable, and murderers, and whoremongers, and sorcerers, and idolaters, and all liars, shall have their part in the lake which burneth with fire and brimstone: which is the second death.
6- Come hither, I will shew thee the bride, the Lamb's wife. And he carried me away in the spirit to a great and high mountain, and shewed me that great city, the holy Jerusalem, descending out of heaven from God, Having the glory of God: and her light was like unto a stone most precious, even like a jasper stone, clear as crystal;* See verses 12 thru 21 for the description of Jerusalem*
7- I saw no temple therein: for the Lord God Almighty and the Lamb are the temple of it.
8- the city had no need of the sun, neither of the moon, to shine in it: for the glory of God did lighten it, and the Lamb is the light thereof. And the nations of them which are saved shall walk in the light of it: and the kings of the earth do bring their glory and honour into it.
9-And the gates of it shall not be shut at all by day: for there shall be no night there. And they shall bring the glory and honour of the nations into it. And there shall in no wise enter into it any thing that defileth, neither whatsoever worketh abomination, or maketh a lie: but they which are written in the Lamb's book of life.
1-What did the angel have in his hand, when he came down from heaven?
2-What did the angel do?
3-What did John see next?
4-What blessings go with the first resurrection?
5-What happens when the thousand years are up?
6-What happened next?
7-What happened when the book of life was opened?
8-What very sad thing happens if your name is not found in the book of life?
Answer for Revelation 20
1-The key to the bottomless pit and a great chain in his hand.
2-He laid hold on the dragon, that old serpent, which is the Devil, and Satan, and bound him a thousand years, 3And cast him into the bottomless pit, and shut him up, and set a seal upon him, that he should deceive the nations no more, till the thousand years should be fulfilled: and after that he must be loosed a little season.
3- I saw thrones, and they sat upon them, and judgment was given unto them: and I saw the souls of them that were beheaded for the witness of Jesus, and for the word of God, and which had not worshipped the beast, neither his image, neither had received his mark upon their foreheads, or in their hands; and they lived and reigned with Christ a thousand years. This is the first resurrection.
4-Blessed and holy is he that hath part in the first resurrection: on such the second death hath no power, but they shall be priests of God and of Christ, and shall reign with him a thousand years.
5- Satan shall be loosed out of his prison, And shall go out to deceive the nations which are in the four quarters of the earth, Gog, and Magog, to gather them together to battle: the number of whom is as the sand of the sea. And they went up on the breadth of the earth, and compassed the camp of the saints about, and the beloved city: and fire came down from God out of heaven, and devoured them. And the devil that deceived them was cast into the lake of fire and brimstone, where the beast and the false prophet are, and shall be tormented day and night for ever and ever.
6-And I saw a great white throne, and him that sat on it, from whose face the earth and the heaven fled away; and there was found no place for them. And I saw the dead, small and great, stand before God
7-the books were opened: and another book was opened, which is the book of life: and the dead were judged out of those things which were written in the books, according to their works. And the sea gave up the dead which were in it; and death and hell delivered up the dead which were in them: and they were judged every man according to their works. And death and hell were cast into the lake of fire. This is the second death.
8- Whosoever was not found written in the book of life was cast into the lake of fire.
1-What was heard in heaven after this?
2-What did the voice that came out of the throne say?
3-What was he told to write?
4-What did John see when heaven opened?
5-What did the angel standing in the sun say?
6-What were the beast and kings of the earth getting ready to do?
1-I heard a great voice of much people in heaven, saying, Alleluia; Salvation, and glory, and honour, and power, unto the Lord our God: For true and righteous are his judgments: for he hath judged the great whore, which did corrupt the earth with her fornication, and hath avenged the blood of his servants at her hand. And again they said, Alleluia And her smoke rose up for ever and ever. 4And the four and twenty elders and the four beasts fell down and worshipped God that sat on the throne, saying, Amen; Alleluia.
2- Praise our God, all ye his servants, and ye that fear him, both small and great. And I heard as it were the voice of a great multitude, and as the voice of many waters, and as the voice of mighty thunderings, saying, Alleluia: for the Lord God omnipotent reigneth. Let us be glad and rejoice, and give honour to him: for the marriage of the Lamb is come, and his wife hath made herself ready. And to her was granted that she should be arrayed in fine linen, clean and white: for the fine linen is the righteousness of saints.
3- Blessed are they which are called unto the marriage supper of the Lamb. And he saith unto me, These are the true sayings of God. And I fell at his feet to worship him. And he said unto me, See thou do it not: I am thy fellowservant, and of thy brethren that have the testimony of Jesus: worship God: for the testimony of Jesus is the spirit of prophecy.
4- I saw heaven opened, and behold a white horse; and he that sat upon him was called Faithful and True, and in righteousness he doth judge and make war. His eyes were as a flame of fire, and on his head were many crowns; and he had a name written, that no man knew, but he himself. And he was clothed with a vesture dipped in blood: and his name is called The Word of God. And the armies which were in heaven followed him upon white horses, clothed in fine linen, white and clean. And out of his mouth goeth a sharp sword, that with it he should smite the nations: and he shall rule them with a rod of iron: and he treadeth the winepress of the fierceness and wrath of Almighty God. And he hath on his vesture and on his thigh a name written, KING OF KINGS, AND LORD OF LORDS.
5-And I saw an angel standing in the sun; and he cried with a loud voice, saying to all the fowls that fly in the midst of heaven, Come and gather yourselves together unto the supper of the great God; That ye may eat the flesh of kings, and the flesh of captains, and the flesh of mighty men, and the flesh of horses, and of them that sit on them, and the flesh of all men, both free and bond, both small and great.
6- I saw the beast, and the kings of the earth, and their armies, gathered together to make war against him that sat on the horse, and against his army. And the beast was taken, and with him the false prophet that wrought miracles before him, with which he deceived them that had received the mark of the beast, and them that worshipped his image. These both were cast alive into a lake of fire burning with brimstone. And the remnant were slain with the sword of him that sat upon the horse, which sword proceeded out of his mouth: and all the fowls were filled with their flesh.
1-What was special about this angel that came down from heaven?
2-What did he say?
3-Another voice was heard from heaven what did he say?
4-How far did her sins reach?
5-What will happen to Babylon now?
6-What are the kings of the earth doing?
7-What were the merchants doing?
8-What did the shipmasters do?
9-What was happening in heaven?
Answers for Revelations 18
1-He had great power, and the earth was lightened with his glory.
2-2And he cried mightily with a strong voice, saying, Babylon the great is fallen, is fallen, and is become the habitation of devils, and the hold of every foul spirit, and a cage of every unclean and hateful bird. For all nations have drunk of the wine of the wrath of her fornication, and the kings of the earth have committed fornication with her, and the merchants of the earth are waxed rich through the abundance of her delicacies.
3- Come out of her, my people, that ye be not partakers of her sins, and that ye receive not of her plagues. For her sins have reached unto heaven, and God hath remembered her iniquities.
4-For her sins have reached unto heaven, and God hath remembered her iniquities. Reward her even as she rewarded you, and double unto her double according to her works: in the cup which she hath filled fill to her double. How much she hath glorified herself, and lived deliciously, so much torment and sorrow give her: for she saith in her heart, I sit a queen, and am no widow, and shall see no sorrow.
5- Therefore shall her plagues come in one day, death, and mourning, and famine; and she shall be utterly burned with fire: for strong is the Lord God who judgeth her.
6- the kings of the earth, who have committed fornication and lived deliciously with her, shall bewail her, and lament for her, when they shall see the smoke of her burning, Standing afar off for the fear of her torment, saying, Alas, alas that great city Babylon, that mighty city! for in one hour is thy judgment come.
7-shall weep and mourn over her; for no man buyeth their merchandise any more14And the fruits that thy soul lusted after are departed from thee, and all things which were dainty and goodly are departed from thee, and thou shalt find them no more at all. The merchants of these things, which were made rich by her, shall stand afar off for the fear of her torment, weeping and wailing, And saying, Alas, alas that great city, that was clothed in fine linen, and purple, and scarlet, and decked with gold, and precious stones, and pearls!
8-Every shipmaster, and all the company in ships, and sailors, and as many as trade by sea, stood afar off, And cried when they saw the smoke of her burning, saying, What city is like unto this great city! And they cast dust on their heads, and cried, weeping and wailing, saying, Alas, alas that great city, wherein were made rich all that had ships in the sea by reason of her costliness! for in one hour is she made desolate.
9-Rejoice over her, thou heaven, and ye holy apostles and prophets; for God hath avenged you on her. And a mighty angel took up a stone like a great millstone, and cast it into the sea, saying, Thus with violence shall that great city Babylon be thrown down, and shall be found no more at all. And in her was found the blood of prophets, and of saints, and of all that were slain upon the earth.
1-What did the angel want to show John?
2-Where did he take him?
3-What did the woman have on?
4-What else did John see about her?
5-The ask John Why do you Marvel?
6-What do the seven heads mean?
7-What do the ten horns mean?
8-What does the water where the whore sat mean?
9-What does the ten horns upon the beast mean?
1- I will shew unto thee the judgment of the great whore that sitteth upon many waters
2- He carried me away in the spirit into the wilderness: and I saw a woman sit upon a scarlet coloured beast, full of names of blasphemy, having seven heads and ten horns.
3-the woman was arrayed in purple and scarlet colour, and decked with gold and precious stones and pearls, having a golden cup in her hand full of abominations and filthiness of her fornication: And upon her forehead was a name written, MYSTERY, BABYLON THE GREAT, THE MOTHER OF HARLOTS AND ABOMINATIONS OF THE EARTH.
4-I saw the woman drunken with the blood of the saints, and with the blood of the martyrs of Jesus: and when I saw her, I wondered with great admiration.
5- I will tell thee the mystery of the woman, and of the beast that carrieth her, which hath the seven heads and ten horns. The beast that thou sawest was, and is not; and shall ascend out of the bottomless pit, and go into perdition: and they that dwell on the earth shall wonder, whose names were not written in the book of life from the foundation of the world, when they behold the beast that was, and is not, and yet is.
6-The seven heads are seven mountains, on which the woman sitteth. And there are seven kings: five are fallen, and one is, and the other is not yet come; and when he cometh, he must continue a short space. And the beast that was, and is not, even he is the eighth, and is of the seven, and goeth into perdition.
7- the ten horns which thou sawest are ten kings, which have received no kingdom as yet; but receive power as kings one hour with the beast. These have one mind, and shall give their power and strength unto the beast. These shall make war with the Lamb, and the Lamb shall overcome them: for he is Lord of lords, and King of kings: and they that are with him are called, and chosen, and faithful.
8-The waters which thou sawest, where the whore sitteth, are peoples, and multitudes, and nations, and tongues.
9-These shall hate the whore, and shall make her desolate and naked, and shall eat her flesh, and burn her with fire. For God hath put in their hearts to fulfil his will, and to agree, and give their kingdom unto the beast, until the words of God shall be fulfilled. And the woman which thou sawest is that great city, which reigneth over the kings of the earth.
1-What did the voice tell the angels to do?
2-The first went, and poured out his vial upon the earth.
3-The second angel poured out his vial upon the sea.
4-The fourth angel poured out his vial upon the sun
5-The fifth angel poured out his vial upon the seat of the beast.
6-The sixth angel poured out his vial upon the great river Euphrates
8-What did Jesus say next?
9-The seventh angel poured out his vial into the air?
10-What happened to Babylon?
11-What happened nex?
1-Saying to the seven angels, Go your ways, and pour out the vials of the wrath of God upon the earth.
2-There fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.
3-It became as the blood of a dead man: and every living soul died in the sea. And I heard the angel of the waters say, Thou art righteous, O Lord, which art, and wast, and shalt be, because thou hast judged thus. For they have shed the blood of saints and prophets, and thou hast given them blood to drink; for they are worthy.
4-Power was given unto him to scorch men with fire. And men were scorched with great heat, and blasphemed the name of God, which hath power over these plagues: and they repented not to give him glory.
5- his kingdom was full of darkness; and they gnawed their tongues for pain, And blasphemed the God of heaven because of their pains and their sores, and repented not of their deeds.
6-The water thereof was dried up, that the way of the kings of the east might be prepared.
7- I saw three unclean spirits like frogs come out of the mouth of the dragon, and out of the mouth of the beast, and out of the mouth of the false prophet. For they are the spirits of devils, working miracles, which go forth unto the kings of the earth and of the whole world, to gather them to the battle of that great day of God Almighty.
8-Behold, I come as a thief. Blessed is he that watcheth, and keepeth his garments, lest he walk naked, and they see his shame. And he gathered them together into a place called in the Hebrew tongue Armageddon.
9-There came a great voice out of the temple of heaven, from the throne, saying, It is done. And there were voices, and thunders, and lightnings; and there was a great earthquake, such as was not since men were upon the earth, so mighty an earthquake, and so great.
10-And the great city was divided into three parts, and the cities of the nations fell: and great Babylon came in remembrance before God, to give unto her the cup of the wine of the fierceness of his wrath. And every island fled away, and the mountains were not found.
11- There fell upon men a great hail out of heaven, every stone about the weight of a talent: and men blasphemed God because of the plague of the hail; for the plague thereof was exceeding great.
1-What was the next sign John saw in heaven.
2-What was the next thing he saw?
3-What was the song they were singing?
4-What did he see next?
5-What did one of the four beasts give the angels?
6-What was the temple filled with?
7-What happened after the temple was filled?
1-Seven angels having the seven last plagues; for in them is filled up the wrath of God.
2-A sea of glass mingled with fire: and them that had gotten the victory over the beast, and over his image, and over his mark, and over the number of his name, stand on the sea of glass, having the harps of God.
3-Singing the song of Moses the servant of God, and the song of the Lamb, saying, Great and marvellous are thy works, Lord God Almighty; just and true are thy ways, thou King of saints. Who shall not fear thee, O Lord, and glorify thy name?
for thou only art holy: for all nations shall come and worship before thee; for thy judgments are made manifest.
4- The temple of the tabernacle of the testimony in heaven was opened: And the seven angels came out of the temple, having the seven plagues, clothed in pure and white linen, and having their breasts girded with golden girdles.
5- Gave unto the seven angels seven golden vials full of the wrath of God, who liveth for ever and ever.
6-The temple was filled with smoke from the glory of God, and from his power.
7- No man was able to enter into the temple, till the seven plagues of the seven angels were fulfilled.
1-Where was the Lamb standing and who was with Him, and what was on their foreheads?
2-What voices did he hear from heaven?
3-Who could only learn this song?
4-What was special about these one hundred forty four thousand men?
5-What did the angel have who flew into the midst of heaven.
6-What did this angel say?
7-What did the next angel announce?
8-What did the next angel announce with a loud voice?
9-What did the voice from heaven tell him to write?
10-What did he see when he looked up?
11-What did the angel say to Him who sat on the cloud?
12- What did He do?
13-What did the other angel have who came out of the temple?
14-What did the angel who came from the alter have power over?
15-What did he want the angel with the sharp sickle to do.
16-What happened when he thrust his sickle into the earth?
17-What came out of the winepress?
18-How high, and how long?
1- A Lamb stood on the mount Sion, and with him an hundred forty and four thousand, having his Father's name written in their foreheads.
2- The voice of many waters, and as the voice of a great thunder: and I heard the voice of harpers harping with their harps:
3- The hundred and forty and four thousand men, which were redeemed from the earth.
4-These are they which were not defiled with women; for they are virgins. These are they which follow the Lamb
whithersoever he goeth. These were redeemed from among men, being the firstfruits unto God and to the Lamb.
5- The everlasting gospel to preach unto them that dwell on the earth, and to every nation, and kindred, and tongue, and people.
6- Fear God, and give glory to him; for the hour of his judgment is come: and worship him that made heaven, and earth, and the sea, and the fountains of waters.
7- Babylon is fallen, is fallen, that great city, because she made all nations drink of the wine of the wrath of her fornication.
8- If any man worship the beast and his image, and receive his mark in his forehead, or in his hand, The same shall drink of the wine of the wrath of God, which is poured out without mixture into the cup of his indignation; and he shall be tormented with fire and brimstone in the presence of the holy angels, and in the presence of the Lamb: And the smoke of their torment ascendeth up for ever and ever: and they have no rest day nor night, who worship the beast and his image, and whosoever receiveth the mark of his name.
9-Blessed are the dead which die in the Lord from henceforth: Yea, saith the Spirit, that they may rest from their labours; and their works do follow them.
10- Behold a white cloud, and upon the cloud one sat like unto the Son of man, having on his head a golden crown, and in his hand a sharp sickle.
11-Another angel came out of the temple, crying with a loud voice to him that sat on the cloud, Thrust in thy sickle, and reap: for the time is come for thee to reap; for the harvest of the earth is ripe.
12- He that sat on the cloud thrust in his sickle on the earth; and the earth was reaped.
13-Also having a sharp sickle.
14-He had power over fire.
15-Thrust in thy sharp sickle, and gather the clusters of the vine of the earth; for her grapes are fully ripe.
16-He gathered the vine of the earth, and cast it into the great winepress of the wrath of God.
17- Blood
18- Unto the horse bridles, by the space of a thousand and six hundred furlongs.
1-What rose up out of the sand of the sea?
2-What did it look like?
3- What was wrong with one of the heads?
4-What did the people do?
5-How long was he given power for?
6-What was he allowed to do?
7-What did the next beast look like, and what could he do?
8-How did he deceive the people of the earth?
9-What did make all people do?
10 What is the number of the beast?
1-A beast rise up out of the sea, having seven heads and ten horns, and upon his horns ten crowns, and upon his heads the name of blasphemy.
2-the beast which I saw was like unto a leopard, and his feet were as the feet of a bear, and his mouth as the mouth of a lion: and the dragon gave him his power, and his seat, and great authority.
3-And I saw one of his heads as it were wounded to death; and his deadly wound was healed: and all the world wondered after the beast.
4-And they worshipped the dragon which gave power unto the beast: and they worshipped the beast, saying, Who is like unto the beast? who is able to make war with him?
5-And there was given unto him a mouth speaking great things and blasphemies; and power was given unto him to continue forty and two months. And he opened his mouth in blasphemy against God, to blaspheme his name, and his tabernacle, and them that dwell in heaven. And it was given unto him to make war with the saints, and to overcome them: and power was given him over all kindreds, and tongues, and nations.
6- And it was given unto him to make war with the saints, and to overcome them: and power was given him over all kindreds, and tongues, and nations. And all that dwell upon the earth shall worship him, whose names are not written in the book of life of the Lamb slain from the foundation of the world.
7-I beheld another beast coming up out of the earth; and he had two horns like a lamb, and he spake as a dragon. 2And he exerciseth all the power of the first beast before him, and causeth the earth and them which dwell therein to worship the first beast, whose deadly wound was healed. And he doeth great wonders, so that he maketh fire come down from heaven on the earth in the sight of men.
8-Deceiveth them that dwell on the earth by the means of those miracles which he had power to do in the sight of the beast; saying to them that dwell on the earth, that they should make an image to the beast, which had the wound by a sword, and did live. And he had power to give life unto the image of the beast, that the image of the beast should both speak, and cause that as many as would not worship the image of the beast should be killed.
9- he causeth all, both small and great, rich and poor, free and bond, to receive a mark in their right hand, or in their foreheads: And that no man might buy or sell, save he that had the mark, or the name of the beast, or the number of his name.
1-What great wonder appeared in heaven?
2- What was she doing?
3-What was the other wonder in heaven?
4-What did his tail do?
5-What was the dragon going to do now?
6-What happened to the child?
7-Where did the woman go?
8-What was going on in heaven?
9-What happen to satan?
10-What did the loud voice say?
11-Heaven rejoiced, but what was the woe to the earth about?
12-What did the dragon do when he saw he was cast down to earth.?
13- How did the woman get away?
14-How did the serpent try to stop her?
15- How did she avoid the flood?
16-What did the dragon do after the woman escaped?
1-A woman clothed with the sun, and the moon under her feet, and upon her head a crown of twelve stars:
2-she being with child cried, travailing in birth, and pained to be delivered.
3-A great red dragon, having seven heads and ten horns, and seven crowns upon his heads.
4-His tail drew the third part of the stars of heaven, and did cast them to the earth
5- The dragon stood before the woman which was ready to be delivered, for to devour her child as soon as it was born
6- she brought forth a man child, who was to rule all nations with a rod of iron: and her child was caught up unto God, and to his throne.
7-And the woman fled into the wilderness, where she hath a place prepared of God, that they should feed her there a thousand two hundred and threescore days.
8- There was war in heaven: Michael and his angels fought against the dragon; and the dragon fought and his angels.
9-the great dragon was cast out, that old serpent, called the Devil, and Satan, which deceiveth the whole world: he was cast out into the earth, and his angels were cast out with him.
10-Now is come salvation, and strength, and the kingdom of our God, and the power of his Christ: for the accuser of our brethren is cast down, which accused them before our God day and night. And they overcame him by the blood of the Lamb, and by the word of their testimony; and they loved not their lives unto the death.
11-Woe to the inhabiters of the earth and of the sea! for the devil is come down unto you, having great wrath, because he knoweth that he hath but a short time.
12-He persecuted the woman which brought forth the man child.
13- And to the woman were given two wings of a great eagle, that she might fly into the wilderness, into her place, where she is nourished for a time, and times, and half a time, from the face of the serpent.
14-And the serpent cast out of his mouth water as a flood after the woman, that he might cause her to be carried away of the flood.
15-The earth helped the woman, and the earth opened her mouth, and swallowed up the flood which the dragon cast out of his mouth.
16-And the dragon was enraged with the woman, and went to make war with the remnant of her seed, which keep the commandments of God, and have the testimony of Jesus Christ.
1-How many days were the two witnesses given?
2-How are they described?
3-What happens if anyone hurts them?
4-What power do they have?
5-What happens to them?
6-How long do their bodies lay in the street?
7-What happens to them after that?
8-What happened in the same hour?
1-One thousand two hundred and 60 days
2-Two olive trees, and two candlesticks standing before God
3-And if any man will hurt them, fire proceedeth out of their mouth, and devoureth their enemies: and if any man will hurt them, he must in this manner be killed.
4-These have power to shut heaven, that it rain not in the days of their prophecy: and have power over waters to turn them to blood, and to smite the earth with all plagues, as often as they will.
5-And when they shall have finished their testimony, the beast that ascendeth out of the bottomless pit shall make war against them, and shall overcome them, and kill them.
6-And they of the people and kindreds and tongues and nations shall see their dead bodies three days and an half, and shall not suffer their dead bodies to be put in graves. And they that dwell upon the earth shall rejoice over them, and make merry, and shall send gifts one to another; because these two prophets tormented them that dwelt on the earth.
7-And after three days and an half the spirit of life from God entered into them, and they stood upon their feet; and great fear fell upon them which saw them. And they heard a great voice from heaven saying unto them, Come up hither. And they ascended up to heaven in a cloud; and their enemies beheld them.
8- And the same hour was there a great earthquake, and the tenth part of the city fell, and in the earthquake were slain of men seven thousand.
The second woe is past.
1-Another mighty angel came down from heaven, what did he look like.
2-What did he have in his hand?
3-What happened when he cried with a loud voice, as when a lion roareth: and when he had cried, seven thunders uttered their voices?
4-What did the angel standing upon the sea and earth say when he lifted up his hands to heaven?
5-What did the voice from heaven say to do?
Answers Revelations 10
1- Clothed with a cloud: and a rainbow was upon his head, and his face was as it were the sun, and his feet as pillars of fire:
2-And he had in his hand a little book open: and he set his right foot upon the sea, and his left foot on the earth.
3-4And when the seven thunders had uttered their voices, I was about to write: and I heard a voice from heaven saying unto me, Seal up those things which the seven thunders uttered, and write them not.
4-6And sware by him that liveth for ever and ever, who created heaven, and the things that therein are, and the earth, and the things that therein are, and the sea, and the things which are therein, that there should be time no longer: 7But in the days of the voice of the seventh angel, when he shall begin to sound, the mystery of God should be finished, as he hath declared to his servants the prophets.
5-9And I went unto the angel, and said unto him, Give me the little book. And he said unto me, Take it, and eat it up; and it shall make thy belly bitter, but it shall be in thy mouth sweet as honey. 10And I took the little book out of the angel's hand, and ate it up; and it was in my mouth sweet as honey: and as soon as I had eaten it, my belly was bitter. 11And he said unto me, Thou must prophesy again before many peoples, and nations, and tongues, and kings.
http://www.newbeginmin1.org/REVELATIONCHAPTER9.html
1- What happened when the fifth angel sounded?
2-What happened when the sixth angel sounded?
3-What were the four angles to do?
4-What was the number of horsemen?
5-Did the people who were left repent?
1-I saw a star fall from heaven unto the earth: and to him was given the key of the bottomless pit. 2And he opened the bottomless pit; and there arose a smoke out of the pit, as the smoke of a great furnace; and the sun and the air were darkened by reason of the smoke of the pit. And there came out of the smoke locusts upon the earth: and unto them was given power, as the scorpions of the earth have power. 4And it was commanded them that they should not hurt the grass of the earth, neither any green thing, neither any tree; but only those men which have not the seal of God in their foreheads. 5And to them it was given that they should not kill them, but that they should be tormented five months: and their torment was as the torment of a scorpion, when he striketh a man. 6And in those days shall men seek death, and shall not find it; and shall desire to die, and death shall flee from them. 7And the shapes of the locusts were like unto horses prepared unto battle; and on their heads were as it were crowns like gold, and their faces were as the faces of men. 8And they had hair as the hair of women, and their teeth were as the teeth of lions. 9And they had breastplates, as it were breastplates of iron; and the sound of their wings was as the sound of chariots of many horses running to battle. 10And they had tails like unto scorpions, and there were stings in their tails: and their power was to hurt men five months. 11And they had a king over them, which is the angel of the bottomless pit, whose name in the Hebrew tongue is Abaddon, but in the Greek tongue hath his name Apollyon.
2- I heard a voice from the four horns of the golden altar which is before God, 14Saying to the sixth angel which had the trumpet, Loose the four angels which are bound in the great river Euphrates.
3- Were prepared for an hour, and a day, and a month, and a year, for to slay the third part of men.
4- Two hundred thousand thousand
1-What happened when the seventh seal was opened?
2-What was given to the seven angels which stood before God?
3-What did the angel who stood at the alter have, and what was given to him, what was he to do?
4-What happened to the smoke of the incense?
5-What happened when the angel took the censer and filled it with the fire of the alter?
6-The seven angels which had the seven trumpets prepared themselves to sound.
What happened when the first angel sounded?
7-What happened when the second angel sounded?
8-What happened when the third angel sounded?
9-What happened when the forth angel sounded?
10-What was the angel flying through the midst of heaven saying?
Answers for Revelations 8
1- There was silence in heaven about the space of half an hour
2- To them were given seven trumpets
3- A golden censer; and there was given unto him much incense, he should offer it with the prayers of all saints upon the golden altar which was before the throne.
4- It came with the prayers of the saints, ascended up before God out of the angel's hand.
5- Cast it into the earth: and there were voices, and thunderings, and lightnings, and an earthquake.
6-There followed hail and fire mingled with blood, and they were cast upon the earth: and the third part of trees was burnt up, and all green grass was burnt up.
7- a great mountain burning with fire was cast into the sea: and the third part of the sea became blood; 9And the third part of the creatures which were in the sea, and had life, died; and the third part of the ships were destroyed.
8- There fell a great star from heaven, burning as it were a lamp, and it fell upon the third part of the rivers, and upon the fountains of waters; 11And the name of the star is called Wormwood: and the third part of the waters became wormwood; and many men died of the waters, because they were made bitter.
9- A third part of the sun was smitten, and the third part of the moon, and the third part of the stars; so as the third part of them was darkened, and the day shone not for a third part of it, and the night likewise.
10-saying with a loud voice, Woe, woe, woe, to the inhabiters of the earth by reason of the other voices of the trumpet of the three angels, which are yet to sound!
1-What were the four angels standing on the four corners of the earth doing?
2-What did the angel from the east have?
3- What did he say?
4-How many servants were sealed, and who were they?
5- Name them, not all 144,000, just the tribes.
6-Where did the great Multi which no man could number, that stood before the Lamb come from?
7- What will they do there?
8-Who will feed them?
9-What will God do for them?
1-Holding the four winds of the earth, so the four winds of the earth would not blow on the earth, nor on the sea, nor on any tree.
2-The seal of the living God
3-He cried with a loud voice to the four angels, to whom it was given to hurt the earth and the sea, saying Hurt not the earth, neither the sea, not the trees, till we have sealed the servants of our God in their forehead.
4- Hundred forty-four thousand 12,000 from each tribes of the children Israel.
5-Juda, Reuben, Gad, Aser, Nephthalim, Manasses, Simeon, Levi, Issachar, Zabulon, Joseph, and Benjamin.
6-They came out of the great tribulation, and have washed their robes, and made them white in the blood of the Lamb.
7-They will serve before the throne of God, serving Him day and night, and He that sitteth on the throne shall dwell among them.
8-They will hunger no more, neither thrist, neither shall the sun light on them, nor heat. For the Lamb shall feed them, and lead them unto living fountains of waters.
9-God shall wipe away all tears from their eyes.
1- When the Lamb opened one of the seals, what happened?
2-What did he see?
3-What happened when he opened the second seal?
4 What did he see?
5-What happened when the third seal was opened?
7-The fourth seal was open and the fourth beast said come and see.
8- What happened when the fifth seal was opened?
9- What did they say?
10-What was their answer?
11-What happened when the sixth seal was opened?
12-What did the people of the earth do?
1-I heard the noise of thunder, one of the beast saying, Come and see.
2-A white horse, and he that sat on him had a bow, and a crown was given unto him: he went forth conquering, and to conquer.
3-The second beast said, Come and see.
4-A red horse: and power was given to him that set thereon to take peace from the earth, and that they should kill one another: and there was given to him a great sword
5-The third beast said come and see?
6-A black horse and he that sat on him had a pair of balances in his hand. And I heard a voice in the midst of the four beasts say, A measure of wheat for a penny, and three measures of barley for a penny; and see thou hurt not the oil and the wine.
7-I saw a pale horse: and his name was Death, and Hell followed with him. The power was given unto them over the fourth part of the earth, to kill with sword, and with hunger, and with death, and with the beast of the earth.
8-I saw under the alter the souls of them that were slain for the word of God, and for the testimony they held.
9-How long, O Lord, holy and true, dost thou not judge and avenge our blood on them that dwell on the earth.
10-White robes were given to them, and it was said they should rest yet for a little season, until their fellow servants also and their brethren, that should be killed as they were, should be full filled.
11-There was a great earthquake, and the sun became black, and the moon became as blood; and the stars of heaven fell, and the heavens parted as a scroll and every mountain and island were moved out of their places.
12-They hid themselves in the dens and rocks of the mountains, asking that the mountains and rocks fall on the to hide them from the face of the Him who sitteth on the throne, and from the wrath of the Lamb.
1-What was God holding in His hand?
2-What was the Scroll sealed with?
3-Who was worthy to open the Scroll?
4-Who was standing in the midst of the elders?
5-What happened when the Lamb took the scroll from Him who sat on the throne?
6-What song did they sing?
7-What were the angels round the throne and the beasts and the elders saying?
8-What was every creature in heaven, on and under the earth and in the sea saying?
9-What did the four beasts say?
10-What did the four and twenty elders do?
1-A Scroll
2-Sealed with seven seals
3-The Lion of the tribe of Judah, the Root of David, has overcome and conquered. He can open it.
4-A Lamb stood as if it had been slain, having seven horns, and seven eyes
5-The four beast, and four and twenty elders fell down before the Lamb.
6-Thou art worthy to take the scroll, and to open the seals.
7-Worthy is the Lamb that was slain to receive power, riches, wisdom, strength, honor, glory, and blessings.
8-Blessing, honor, glory,and power, be unto Him that sitteth upon the throne, and unto the Lamb forever and ever.
9-Amen
10-Fell down and worshipped Him that liveth forever and ever.
1-What did John see in His hand?
2-What was the angel proclaiming?
3-Why did John cry?
4-What did the elder say to John?
6-What happened when the Lamb took the book?
7- What was the number of angels John heard?
8- What were they saying?
9-What did John hear every creature in heaven, on the earth, and in the sea saying?
10-What did the 4 Beasts and twenty-four elders do?
1-A scroll written inside and on the back, sealed with seven seals.
2-“Who is worthy to open the scroll and to loose its seals?”
3-Because no man was found worthy to open and to read the book, neither to look thereon.
4-Weep not: behold, the Lion of the tribe of Judah, the Root of David, hath prevailed to open the book, and to loose the seven seals thereof.
5-And I beheld, and, lo, in the midst of the throne and of the four beasts, and in the midst of the elders, stood a Lamb as it had been slain, having seven horns and seven eyes, which are the seven Spirits of God sent forth into all the earth.
6-The four beasts and four and twenty elders fell down before the Lamb, having every one of them harps, and golden vials full of odours, which are the prayers of saints.
And they sung a new song, saying, Thou art worthy to take the book, and to open the seals thereof: for thou wast slain, and hast redeemed us to God by thy blood out of every kindred, and tongue, and people, and nation
7-The number of them was ten thousand times ten thousand, and thousands of thousands
8- Worthy is the Lamb that was slain to receive power, and riches, and wisdom, and strength, and honour, and glory, and blessing.
9-Blessing, and honour, and glory, and power, be unto him that sitteth upon the throne, and unto the Lamb for ever and ever.
10-Fell down and worshipped him that liveth for ever and ever.
1-What did the angel tell the dead church?
2-What did the angel tell the Faithful Church?
3-What did the angel tell the Lukewarm church?
4-What did the voice sound like that spoke to John?
5-What did the voice say?
7-What did the four living creatures look like?
8-What were the four living creatures saying?
9-What happened when the living creatures give glory and honor and thanks to Him who sits on the throne, who lives forever and ever?
10-What do the elders say?
1-Your works are dead;
hold fast and repent
if you will not watch, I will come upon you as a thief, and you will not know what hour I will come upon you
He who overcomes shall be clothed in white garments, and I will not blot out his name from the Book of Life; but I will confess his name before My Father and before His angels.
“He who has an ear, let him hear what the Spirit says to the churches.”
2-These things says He who is holy, He who is true, “He who has the key of David, He who opens and no one shuts, and shuts and no one opens
Because you have kept My command to persevere, I also will keep you from the hour of trial which shall come upon the whole world, to test those who dwell on the earth. Behold, I am coming quickly! Hold fast what you have, that no one may take your crown. He who overcomes, I will make him a pillar in the temple of My God, and he shall go out no more. I will write on him the name of My God and the name of the city of My God, the New Jerusalem, which comes down out of heaven from My God. And I will write on him My new name.
3- “I know your works, that you are neither cold nor hot. I could wish you were cold or hot. So then, because you are lukewarm, and neither cold nor hot, I will vomit you out of My mouth.
Because you say, ‘I am rich, have become wealthy, and have need of nothing’—and do not know that you are wretched, miserable, poor, blind, and naked—
Therefore be zealous and repent. Behold, I stand at the door and knock. If anyone hears My voice and opens the door, I will come in to him and dine with him, and he with Me. To him who overcomes I will grant to sit with Me on My throne, as I also overcame and sat down with My Father on His throne.
4-Like a trumpet speaking
5-“Come up here, and I will show you things which must take place after this.”
6-A throne set in heaven, and One sat on the throne.
7-First living creature was like a lion, the second living creature like a calf, the third living creature had a face like a man, and the fourth living creature was like a flying eagle. The four living creatures, each having six wings, were full of eyes around and within. And they do not rest day or night
8- “ Holy, holy, holy,
Lord God Almighty,
Who was and is and is to come!”
9-The twenty-four elders fall down before Him who sits on the throne and worship Him who lives forever and ever, and cast their crowns before the throne.
10-“ You are worthy, O Lord,
To receive glory and honor and power;
For You created all things,
And by Your will they exist and were created.”
Revelations 1 & 2
1-How does Jesus refer to Himself in Rev 1?
2-Where was John when given revelations?
3-What was John to do with what he saw?
4-Where were the church's, and what were their names?
5-What happened when John saw Jesus?
6-What did Jesus do?
7-What does Jesus have the keys to?
8-What did the Spirit say to the churches?
9-Where is the tree of life?
10-What did the Spirit say to the churches?
ANSWERS for Revelations 1&2
1-Alpha and Omega, the beginning and the end, which is, and which was, and which is to come, the Almighty.
2-Isle of Patmos
3-Write it in a book and send it to the seven churches.
4-Asia....Ephesus, Smyrna, Pergamos, Thyatira, Sardis, Philadelphia, and Laodicea.
5-He fell as dead at His feet.
6-He laid His right hand on him, saying "fear not."
7-The keys of hell and of death
8-To him that overcometh will I give to eat of the tree of life.
9-Midst of the paradise of God
10-To him that overcometh will I give to eat of the tree of life
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Under each chapter number I'm putting the link to Rev's studies in Revelation's. If you have any questions you can go to her study and find help understanding it.
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As well as the array of shops that Knightsbridge has to offer, it also has a wealth of bars, restaurants and eateries to while away the time in. This being Knightsbridge - and home to some of London's richest residents - these are all fairly upmarket. That doesn't mean there's nowhere to locate an affordable bite to eat, though. Like the housing, sheer variety is your choice here.
If it's warm, why bother with a stuffy bar or pub at all? Grab some beers and a picnic and head out to the district's local green space - the truly wonderful Hyde Park.
Knightsbridge is very close to being at the centre of London, but for those rare occasions when you don't want to walk into town (while tottering along in high heels on a night out, for instance, or while staggering back after too many beers at the football match) there are plenty of options for local travel. Knightsbridge Underground Station is served by the Piccadilly Line which offers regular services to Covent Garden and Leicester Square - perfect for an impromptu night out or similar.
Despite the expense of living in Knightsbridge, it really is worth it if you can afford it. Why do you think so many of the world's richest choose to live here?
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This spectacular imaginative property sits in one of the most desirable locations in London and seldom comes available in the rental market. It covers 8139 square foot and benefits from almost 2000 square feet of terracing, with its principle rooms having panoramic views over Hyde Park. The penthouse is presented in exceptional condition and offers amazing living and entertaining quarters with elegant décor. The property comprises of a large eat-in kitchen with integrated appliances, stunning dining room, home cinema, library, gym, and MASTER bedroom with his/her bathrooms and built-in wardrobes, FIVE further bedrooms (three with en-suite), two further bathrooms, treatment room and two balconies. The penthouse also benefits from a lift that opens directly into a private lobby, parking and separate staff accommodation are also available. The prestigious location offers acres of recreational space and the picturesque Serpentine Lake with Knightsbridge Underground Station (Piccadilly Line) only a short walk.
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War’s Lingering Phantoms
February 28, 2013 By: NCVeditor Category: Politics, Robert C. Koehler
Hearing the Stories as a Prelude to Rebuilding
by Robert C. Koehler
“War’s lingering phantoms haunt every society.”
As two hellish, costly and needless wars struggle toward collapse, this is the time — now, right this minute, before the next false alarm goes off — for us to look honestly at the cost and quality of national security based on militarism. It’s time to squeeze the romance out of war and get it through our heads that war is not inevitable.
War is just another form of mass murder. Its core principle is dehumanization — of all participants, the enemy and the good guys. This is because you can’t hate, dehumanize and train to kill “the other” without dehumanizing yourself and damaging your soul.
“Kill! Kill! Kill, without mercy, Sergeant! . . . Blood! Blood! Bright red blood, Sergeant!”
The dehumanization happens at an individual level, to soldiers who, in basic training, go through an intense process of overriding their humanity and establishing “muscle memory” that allows them to kill on command; and who then participate in the killing of the enemy — often enough, in our current wars, the killing of civilians, including children — in battle situations.
And the dehumanization also happens, less perceptibly, perhaps, at a collective level, to whole societies that pump themselves into a war mentality and think they’re protecting themselves and their values, only to see the suffering they inflict come home and the values go permanently on hold.
A new term for this brokenness, this deep loss of one’s humanity, has emerged: moral injury.
The quotes are from Soul Repair: Recovering from Moral Injury after War (Beacon Press), by Rita Nakashima Brock and Gabriella Lettini. This remarkable book, published in 2012, takes a long, hard look at the dehumanizing effects of war, through the experiences of a number of vets from various wars (Vietnam, Iraq, Afghanistan) who share their suffering — and bare their wounded souls — to the authors.
Soul Repair is an assault on the mythology and public relations of war, on the default setting of nationhood, that: “We sleep comfortably in our beds at night because violent men do violence on our behalf.” No matter how many lies are at the foundation of a given war, no matter how disastrously unnecessary and destructive — oops — it turns out to be in retrospect, the myth of war is ever-unsullied: This time the danger is really there. This time it’s crucial that we carpet bomb civilians, then send in our boys and girls to clean out the enemy insurgents. This time it’s really for democracy and the American Dream and a good night’s sleep.
Just as soldiers are on the front line of the fight, they are also on the front line of its aftermath, bearing their wounds — physical and spiritual — by themselves. Even if they fought in a “good” war, popular, celebrated and appreciated, they are alone with what they witnessed and participated in. When a war is deeply criticized at home, bearing what one has done in it often becomes impossible.
“Self-harm is now the leading cause of death for members of the Army, which has seen its suicide rate double since 2004, peaking this past summer with 38 in July alone,” Tony Dokoupil wrote in a Newsweek article about moral injury last December. “But the risk to discharged veterans may be even greater. Every month nearly 1,000 of them attempt to take their own lives. That’s more than three attempts every 90 minutes, at least one of them successful. . . . ‘It’s an epidemic,’ Secretary of Defense Leon Panetta admitted to Congress this summer. ‘Something is wrong.’”
Tyler Boudreau, one of the vets quoted in Soul Repair, puts it this way: “They say war is hell, but I say it’s the foyer to hell. I say coming home is hell, and hell ain’t got no coordinates. . . . Hell is no place at all, so when you’re there, you’re nowhere — you’re lost.”
Another vet, Joshua Casteel, who gained conscientious objector status in 2005, says “he began to think about why a so-called peaceful society relies on war for its security, and what it means to train ordinary young people to be killers.”
This question, it seems to me, strikes at the heart of who we are as a society. Like the other vets who tell their stories in Soul Repair, he had to rebuild his life and reclaim his humanity by reaching for something beyond what could ever be gained by war. For Casteel, this meant traveling with Christian Peacemaker teams, living in war zones around the globe and establishing a peaceful presence.
Boudreau spoke stunningly about his reclamation of humanity: “Digging in has always been, for me, about killing or keeping myself from being killed. In war, soldiers score the earth with their shovels, some of them essentially digging their own graves. The first time I pressed the heel of my boot at home on a garden spade I felt the shift inside me like tectonic plates beneath the surface.”
Personal stories such as these are the core of Soul Repair, but the authors push beyond the personal as well. War and its aftermath — “war’s lingering phantoms” — belong to all of us, they write. Let’s at least acknowledge those phantoms and let them unsettle us. This is the prelude to rebuilding.
Robert C. Koehler is an award-winning, Chicago-based journalist and nationally syndicated writer, and a Contributing Author for New Clear Vision. His new book, Courage Grows Strong at the Wound (Xenos Press) is now available. Contact him at [email protected], visit his website at commonwonders.com, or listen to him at Voices of Peace radio.
Tags: dehumanization, morality, soldiers, story, veterans, war
New Clear Vision (@newclearvision) 28 02 13
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Home » ECCO Introduces Men's Tour Hybrid Golf Shoes
ECCO Introduces Men's Tour Hybrid Golf Shoes
By Ottawa Golf Blog Posted at 10/10/2012 07:23:00 PM 1 comment
ECCO continues to roll out some great looking and feeling golf shoes. We've done a few ECCO golf shoe reviews here at Ottawa Golf Blog and look forward to Q1 2013 when ECCO will debut the ECCO Tour Hybrid here in Canada. The Tour Hybrid is the first-ever crossover model featuring a classic leather upper design atop the company’s award-winning Street outsole.
ECCO Tour Hybrid Adds Sophistication to Golf’s Fastest-Growing Footwear Category
Danish Brand’s Pioneering Spirit Continues to Drive Market Trends
(Markham, Ontario) – Danish brand ECCO – a leading global manufacturer of innovative footwear – announces the launch of its men’s Tour Hybrid model, the first-ever crossover model featuring a classic leather upper design atop the company’s award-winning Street outsole.
By combining hand-crafted elegance with advanced shoemaking technologies, ECCO has created a style which uniquely and seamlessly transitions from the boardroom to the car to the country club. Suitable for business and casual settings, Tour Hybrid boasts a patented outsole configuration of approximately 100 molded traction bars and 800-plus traction angles. Constructed from TPU – a highly durable, wear-resistant material – these elements provide superior grip in all conditions.
“It’s in our DNA to pioneer comfort, performance and style trends,” says Michael Waack, Head of Global Golf at ECCO. “With each collection, we want to excite the trade and consumer markets while leaving them wondering what will be our next innovation.”
Additional features of the refined new Tour Hybrid include:
Three distinct upper patterns and several color options to suit a variety of looks
Supremely weather resistant Hydromax™ leathers
Lining made from Second Skin – the world’s softest leather – which wicks moisture and creates a rich interior feel
Removable ECCO Comfort Fibre System insole increases air circulation and creates a fresh, cool shoe climate
Tour Hybrid models will begin arriving in Canada in Q1 2013. This and other styles from the latest ECCO men’s golf collection will be worn in competition by Fred Couples, Graeme McDowell, Thomas Bjorn, Thorbjørn Olesen, Thongchai Jaidee, Stuart Appleby, Bradley Dredge, Andreas Hartø and scores of other Tour stars worldwide.
The only major shoe manufacturer to own and manage every step of the shoemaking process – from leather production through its own shoe factories all the way to its stores – ECCO adheres to the design philosophy that “the shoe must follow the foot.” This approach allows the company to craft footwear that combines style and comfort with uncompromising quality and innovative technology. A leading global brand, ECCO was founded in 1963 by Karl Toosbuy and remains family owned. Headquartered in the Danish towns of Bredebro and Tønder, the ECCO footwear group employs nearly 20,000 people worldwide. Its products can be found in 4,000 branded sales locations in more than 90 countries.
ECCO retail locations in Canada include Toronto, Montreal, Halifax, Saskatoon, Calgary, Edmonton and Vancouver. Along with ECCO retail stores, there are more than 400 retailers across Canada that carry the ECCO brand.
ECCO Shoes Canada Inc. is based in Markham, Ontario. For more information, please visit www.eccocanada.com or call 1.800.358.3226.
footwear said...
Listening for the Voice of Vocation, by Parker Palmer. He gets at it this way
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Parnassus Classical CDs and Records
Classical CDs and Re-issues of Quality and Convenience
Our Own CDs
Parnassus Wins Legal Victory
Sviatoslav Richter CDs
Sviatoslav Richter – Richter in Brooklyn – PACD 96061/2
PACD 96056 Richter Rarities with Orchestra
Sviatoslav Richter in the 1940s
Sviatoslav Richter – Szymanowski – Limited Edition – Richter 100 Series
Some thoughts about Szymanowski
Richter in Warsaw: The Scriabin Recital
Richter in Leipzig
Sviatoslav Richter Live in the 1950s: Volume One
Sviatoslav Richter Live in the 1950s: Volume Two
Sviatoslav Richter Live in the 1950s: Volume Three
Sviatoslav Richter Live in the 1950s: Volume Four
Sviatoslav Richter Live in the 1950s: Volume Five
Sviatoslav Richter Live in the 1950s: Volume Six
Sviatoslav Richter Live in the 1950s: Volume Seven
Colorado Quartet CDs
Colorado Quartet – Early Beethoven Quartets
Colorado Quartet: Beethoven Quartets
Colorado Quartet: Late Beethoven String Quartets
Colorado Quartet: Schubert & Mendelssohn
Colorado Quartet: Brahms
Various Artists – Black Swans – PACD 96067
Copland: Before the LP
Janos Starker: The Road to Cello Playing +
Erwin Schulhoff: His Complete Piano Recordings
Eugene Drucker – Bach: Solo Violin Sonatas and Partitas
The Lost Art of Jacob Lateiner
Katherine Hoover: String Quartets and Trio
Piano Music of Katherine Hoover
Kokopeli: Katherine Hoover Plays
Night Skies: Orchestral Music of Katherine Hoover
Carole Bogard: A Collection of American Songs
Carole Bogard Sings Baroque Cantatas and Arias
Prokofiev and Stravinsky – Composers Conduct
The Stuyvesant Quartet Plays 20th Century Quartets
Arthur Grumiaux: The Boston Recordings
Kipnis and Kushner – Piano, 4 Hands
Carole Bogard: A Century of French Songs
Handel – Tamerlano
Danielle Woerner Sings Luening and Starer
Gregorian Chant: The Early Interpreters
Tom McDermott – All The Keys And Then Some
DVD – Inesa Sinkevych in Havana
DVD – Sviatoslav Richter Plays Beethoven and Chopin
DVD – Sviatoslav Richter Plays Mozart Concertos
DVD – Sviatoslav Richter Plays Schumann & Russians
DVD – Janos Starker Cello Recital
DVD – Mravinsky Conducts Shostakovich
Discography: The Recorded Legacy of Sviatoslav Richter 1947-2012
Read about Parnassus’s Legal Victory
Buy Richter in Brooklyn via Amazon
Download Richter in Brooklyn from iTunes
Buy from ArkivMusic
PACD 96061/2 – Sviatoslav Richter in Brooklyn
UNPUBLISHED ! 2 CD set – Live 1965 concert from Brooklyn, complete, + unpublished recording of the Gershwin Piano Concerto
Click here for complete contents and notes about Sviatoslav Richter in Brooklyn
Buy Sviatoslav Richter in the 1940s via Amazon (CD or MP3)
PACD 96059/60 Sviatoslav Richter in the 1940s
There is still something powerful and mysterious about opening a window on the earliest documented decade of Richter’s career. The two items which begin Disc 2 of this set are the earliest reliably authenticated recordings of Richter performances yet published. The remaining material in this set is also thoroughly authentic, including a complete recital from 1948.
Unlike the Richter in the 1950s series, all of these recordings have previously been published, although in obscure and now-unobtainable editions. Although these items are not entirely new, we felt that few collectors have had access to them previously.
Click here for complete contents and notes about Sviatoslav Richter in the 1940s
Sviatoslav Richter – Bach: The Well-Tempered Clavier – Live Innsbruck 1973 – PDVD 1505
This recording is one of the greatest rarities in the Richter discography. It was issued in Japan as a memorial tribute to Richter shortly after his death and circulated only there for a very short time. We are pleased to present this invaluable recording to a worldwide audience of Richter collectors for the first time.
In order to serve the dual interests of quality and economy, we have decided to publish this recording in DVD Audio format. This format enables us to include the entire recording on a single affordable disc while maintaining maximum audio quality.
This disc should play audio through any modern DVD or Blu-Ray player.
Click here for complete contents and notes about Sviatoslav Richter – Bach: The Well-Tempered Clavier – Live Innsbruck 1973 – PDVD 1505
PACD 96054/5 Sviatoslav Richter – Szymanowski – Limited Edition – Richter 100 Series
Note: Our arrangement with Polish Radio allows for the production of only 1500 copies. The set will not be reprinted once the initial pressing is sold.
Sviatoslav Richter was a great advocate of the music of Karol Szymanowski. In 1982, to commemorate the 100th anniversary of Szymanowski’s birth, Richter put together two complete concerts of Szymanowski’s music. He was joined by soprano Galina Pisarenko and by violinist Oleg Kagan. For these concerts Richter revived works he had played previously and added the two song cycles, two Mazurkas, and the Sonata No. 3 to his repertoire. Click here for complete contents and notes about Sviatoslav Richter – Szymanowski – Limited Edition – Richter 100 Series
Buy from Amazon (CD or Download)
All of these recordings have been published before. But all have become great rarities, and most of the original publications were filled out with extraneous material. Many collectors will find this new edition worthwhile for the Ravel Concerto alone, but the other works are very substantial bonuses.
Click here for complete contents and notes about Richter Rarities with Orchestra
Buy Sviatoslav Richter in the 1950s Volume 1 via Amazon (CD or MP3)
Buy Sviatoslav Richter in the 1950s Volume 1 via ArchivMusic (CD or MP3)
Download Sviatoslav Richter in the 1950s, Volume 1 via iTunes
PACD 96001/2 Sviatoslav Richter Live in the 1950s Volume 1 recorded in 1954 and 1958, includes the only live concert performances published of Richter playing two major works: Prokofiev’s Piano Sonata No.7, which was written for him, and Tchaikovsky’s Piano Sonata in G Op.37. Click here for complete contents and reviews of Sviatoslav Richter Live in the 1950s Volume 1
Download Sviatoslav Richter in the 1950s, Vol. 2 – Sviatoslav Richter via iTunes
PACD 96003/4 Sviatoslav Richter Live in the 1950s Volume Two was recorded in Moscow in 1952 through 1957. All selections are previously unpublished on CD or LP, with the exception of the Scriabin Sonata No. 6, which now appears for the first time as part of the complete recital. This set includes the only live concerts appearance of Richter playing Schumann’s Humoreske, Op.20, and the earliest one of him playing the Tchaikovsky First Piano Concerto. It also includes the earliest recording of Richter playing one of his greatest interpretations, Mussorgsky’s Pictures at an Exhibition, in a virtuoso performance from 1952 which contrasts interestingly with his better-known Sofia performance from 1958. Click here for complete contents.
Sviatoslav Richter in the 1950’s Volume 3 via Amazon (CD or MP3)
Buy Sviatoslav Richter Live in the 1950’s: Volume 3 via ArchivMusic (CD or MP3)
Download Sviatoslav Richter in the 1950s, Vol. 3 from iTunes
PACD 96005/6 Sviatoslav Richter Live in the 1950s Volume Three was recorded at Moscow recitals in 1954 and 1958. None has ever been published before on CD or LP. The 1958 material included some major discoveries. Most of it is made up of pieces from Liszt’s Années de Pélèrinage, only one of which exists in any other Richter recording. It also offers the offers the only live performance published of Richter playing Beethoven’s famous “Pathétique” Sonata. The 1954 recital includes mostly works of Ravel, including the published Richter performance of Le Gibet from Gaspard de la Nuit , the only selection of that suite he ever played. Two more of the Ravel works, Pavanne pour une infant défunte and Jeux d’eau, are the only Richter performances yet published on CD. The disc concludes with three pieces by Rachmaninov and one by Prokofiev. Click here for complete contents listing.
Sviatoslav Richter in the 1950s, Vol. 4 – Sviatoslav Richter
PACD 96013/4 Sviatoslav Richter Live in the 1950s Volume Four was recorded at Moscow recitals in 1954 and 1956. the obvious highlight of this set is a 1954 performance of Beethoven’s Third Piano concerto conducted by Herman Abendroth, during a visit to Moscow. It was Richter’s only performance with Abendroth, and it crackles with ntensity. the other material is Prokofiev’s Sonatas Nos. 6 and 9 and Gavotte from Cinderella, eight of Shostakovich’s Preludes and Fugues (the largest group Richter ever played at one recital), Bartók’s 15 Hungarian Peasant Songs,, and Scriabin’s Vers La flamme and Poème. All of the recordings are previously unpublished. Click here for complete contents listing.
Download Sviatoslav Richter in the 1950s Volume 5 from iTunes
PACD 96017/18 Sviatoslav Richter Live in the 1950s Volume Five includes:
FRANZ SCHUBERT (1797 – 1828): Piano Sonata in B flat D 960; CLAUDE DEBUSSY (1862 – 1918): Prelude No. 11 “La Danse de Puck”; KAROL SZYMANOWSKI (1882 – 1937): Piano Sonata No. 2 in A minor, Op. 21; WOLFGANG AMADEUS MOZART (1756 – 1791): Piano Sonata in A minor KV 310; FRANZ LISZT (1811 – 1886): Harmonies Religieuses et Poetiques: No. 4; Poloniase No. 2; Hungarian Rhapsody No. 17; Consolation No. 6; Scherzo & March; ROBERT SCHUMANN (1810 – 1858): 4 Fugues, Op. 72
Buy Sviatoslav Richter in the 1950’s: Volume 6 via Amazon (CD or MP3)
Buy Sviatoslav Richter Live in the 1950s: Volume Six via ArchivMusic (CD or MP3)
PACD 96025 – Sviatoslav Richter Live in the 1950s Volume 6
This somewhat mysterious concert introduces two new composers (Liadov and Borodin) to the Richter canon. In total, five of the items on the CD are new to the recorded repertoire. The sound of the original recordings was gratifyingly fine and was subject to no audio processing. Click here or on disc image for full contents
Buy Richter in Leipzig via Amazon (CD or MP3)
Buy Richter in Leipzig via ArchivMusic (CD or MP3)
Download Richter in Leipzig from iTunes
PACD 96032 Richter in Leipzig Long-suppressed, this re-issue of the legendary 1963 Leipzig recital features Richter at his incendiary best. The overall sound is improved and the flutter of the original largely gone. Click the disc image or here for complete contents
Buy Richter in the 1950s, Vol. 7 via Amazon (CD or MP3)
Buy Richter in the 1950s, Vol. 7 via ArchivMusic (CD or MP3)
Download Sviatoslav Richter in the 1950s, Vol. 7 via iTunes
PACD 96046/7 Sviatoslav Richter Live in the 1950s Volume 7 Parnassus’s ongoing documentation of the little-known early period of Sviatoslav Richter’s career continues with a monumental, mostly unpublished Beethoven recital from 1951. While there are well-known recordings of Richter playing the “Diabelli” Variations from 1971 and 1986, this is the earliest documented performance of his playing of the music. Of the material in this concert, only the “Diabelli” Variations has ever been published before. The remaining material from this concert has never been published in any form. Click here for complete contents of Sviatoslav Richter in the 1950s Volume 7
Buy Richter in Warsaw: The Scriabin Recital via Amazon (CD or MP3)
Buy Richter in Warsaw: The Scriabin Recital via ArchivMusic (CD or MP3)
Download Richter in Warsaw: The Scriabin Recital via iTunes
PACD 96053 Richter in Warsaw: The Scriabin Recital
In 1972, Sviatoslav Richter chose to commemorate the 100th anniversary of the birth of Alexander Scriabin by performing an all-Scriabin program in three locations. These concerts, while not quite unique, were very uncommon events in Richter’s career. He did not often give concerts devoted to a single composer. Although he played Scriabin’s music throughout his career, concerts devoted entirely to that composer were very scarce; he performed them in public only in 1945, 1957, and in 1972.
Buy Sviatoslav Richter Plays Beethoven & Chopin DVD via Amazon
Buy Sviatoslav Richter Plays Beethoven and Chopin DVD via ArchivMusic
Sviatoslav Richter fans will also be interested in our first DVD: Sviatoslav Richter Plays Beethoven and Chopin. Live performances of Sviatoslav Richter never before available in the West. These videos, filmed at the Great Hall of the Moscow Conservatory in October of 1976, show Richter in his prime playing as a soloist in front of an audience.
Buy Sviatoslav Richter Plays Schumann & Russians DVD via Amazon
Buy Sviatoslav Richter Plays Schumann & Russians DVD via Archiv Music
Our second Sviatoslav Richter DVD, PDVD 1203 – Sviatoslav Richter Plays Schumann and Russians, presents the maestro in a complete performance of Faschingsschwank aus Wien, a Richter specialty, from 1976. The remainder of this program presents shorter Schumann works, including another great Richter specialty, the Toccata, all from a 1985 concert. The second program on the disc is almost all Russian music, works of Tchaikovsky and Rachmaninov, from a concert of 1982. As a bonus, we include a couple of electric peformances of Debussy
From noted Richter scholar, Falk Schwarz:
The Recorded Legacy of Sviatoslav Richter 1947-2012
A remarkable work. The result of years of research and dedication.
A review of Richter recordings which mentions Parnassus can be found at The Berkshire Review
Many of the pages listed above also link to reviews.
Parnassus Records are distributed in the U.S. by E1, in Italy by La Tosca, and elsewhere by alto distribution and associates (see http://altocd.com/international-distributors for listing). If you cannot find them at your favourite record store, please ask for them and please take a moment to email us
Parnassus CDs are distributed in the U.S. by Alliance and elsewhere by alto distribution and associated distributors.
Copyright © 2020 Parnassus Classical CDs and Records - All Rights Reserved - Sitemap
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The BBC Concert Orchestra has a wintry themed concert at the Queen Elizabeth Hall on Wednesday 5 December 2018. Conducted by Bramwell Tovey, the orchestra will be playing works written specially for them including the premiere of a new pieces by the orchestra's composer-in-residence Dobrinka Tabakova, and by the BBC Proms Inspire composer Sarah Jenkins. Also in the programme is music by Jonny Greenwood, and Anne Dudley, with Guy Barker's trumpet concerto played by Alison Balsom.
Alison Balsom and the orchestra premiered Guy Barker's Trumpet Concerto (The Lanterne of Light) at the BBC Proms in 2015. The work is based on a 1409–10 English tract, The Lanterne of Light, which provided a classification system based on the Seven Deadly Sins, establishing that each sin had an associated demon, and Guy Barker's trumpet concerto of the same name is as much about the
character of the demons as the human manifestation of those sins.
Guy Barker is a former Composer-in-Residence with the BBC Concert Orchestra, and the current Composer-in-Residence is Dobrinka Tabakova and the concert will not only include the premiere of her Tectonic, but also her Orpheus Comet which written for the orchestra. Another former Composer-in-Residence is Jonny Greenwood (perhaps best known as the guitarist from Radiohead), and the concert includes his Suite from Norwegian Wood
Full details from the Southbank Centre's website.
Posted by Planet Hugill at Monday, December 03, 2018
The year 2018 in opera and concert reviews
A concerto for silent soloists: my encounter with ...
'From the New World' in Slovenia
That old thing: remembering Covent Garden's reviva...
The Medieval Tendency
A Merry Christmas and Happy New Year
Looking back - in case you missed it
Bach's Christmas Oratorio at St John's Smith Squar...
Illuminating a neglected work: John Andrews & the ...
Seasonal touches: The Tallis Scholars at St John's...
The Dead City: Robert Carsen's new production of K...
Cause for Celebration: Roxanna Panufnik on the Las...
The Sixteen at Christmas - The Little Child
A mash up of Gilbert & Sullivan and the Carry On f...
Images of Jonathan Dove's 'Marx in London' at Thea...
Messiah in Berlin: Handel's oratorio staged in the...
…Everyone is a Child of the Inbetween…
A triumphal Messiah
Towards the Global Digital Jukebox
Echoes of Parsifal: songs and piano music by Robin...
Clarinettist dedications - Roeland Hendrikx in thr...
Annual Christmas Round-up
Reviving Mozart in Wales & family connections in M...
Chocolate covered fairy-tale: Hänsel und Gretel at...
Looking ahead: Music, Spirituality, Wellbeing and ...
Joyous discovery: Alessandro Scarlatti's Messa per...
Celebrating their centenary - Oslo Philharmonic Or...
Looking Ahead: Aldeburgh 2019 - Thomas Larcher, Ma...
Powerful memorial: composer Andrew Smith on his Re...
Looking Ahead: Dartington 2019 - Joanna MacGregor'...
Christmas in Leipzig - Solomon's Knot
Inspired by Cage and Rauschenberg
Winter Fragments: Chamber music by Michael Berkele...
Intimate delight, 18th century chamber cantatas fr...
A new record label, a new disc: I chat to Latvian ...
Ideal & Flying Height: Celebrating Brian Ferneyhou...
Simon Thacker’s Svara-Kanti: Trikala
W11 Opera - Shadowtracks
Truly scrumptious: the choir of St George's Chapel...
Lookng ahead: The London Schools Symphony Orchestr...
Late-Edwardian fairytale: Stanford's The Travellin...
Profoundly beautiful: Simon Boccanegra at the Roya...
Last Man Standing: Cheryl Frances-Hoad premiere at...
Images of Silent Night: Kevin Puts' opera at Opera...
One crazy day: Jonathan Dove on his new opera Marx...
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Review - Hex Hall / Rachel Hawkins
Three years ago, Sophie Mercer discovered that she was a witch. It's gotten her into a few scrapes. Her non-gifted mother has been as supportive as possible, consulting Sophie's estranged father--an elusive European warlock--only when necessary. But when Sophie attracts too much human attention for a prom-night spell gone horribly wrong, it's her dad who decides her punishment: exile to Hex Hall, an isolated reform school for wayward Prodigium, a.k.a. witches, faeries, and shapeshifters.
By the end of her first day among fellow freak-teens, Sophie has quite a scorecard: three powerful enemies who look like supermodels, a futile crush on a gorgeous warlock, a creepy tagalong ghost, and a new roommate who happens to be the most hated person and only vampire on campus. Worse, Sophie soon learns that a mysterious predator has been attacking students, and her only friend is the number-one suspect.
As a series of blood-curdling mysteries starts to converge, Sophie prepares for the biggest threat of all: an ancient secret society determined to destroy all Prodigium, especially her.
Spoilers - beware.
Review - Cross Harry Potter , Evernight and an episode of Supernatural (sans hot brothers) and you have Hex Hall. Actually, wait. Perhaps that's over simplifying it and dumbing it down for the Twilight masses? The premise isn't new in the dearth of paranormal tales scattering the YA shelves but Hawkins has managed something quite interesting. She's made her protagonist real. It sounds simple but many authors couldn't do this in their wildest dreams. Sophie is exceptionally well crafted - vulnerable yet ballsy, snarky yet insightful, independent yet craving acceptance. What can I say? I liked the witch!
The strength in Sophie is that she didn't need any of the mystical problems to carry the story, she did that solo. As do the majority of the supporting players. Sophie, her roommate, her boy crush and even her absentee father could all have worked in a contemporary, urban romance.
Hex Hall most probably sold itself with the strong writing and en vogue premise - let's face it, paranormal is the bee's knees at the moment. I am hoping that they saw what I did. The fantastic protagonist who is a delight from her ordinary looks to her snappy inner dialogue and her penchant for dirty jokes that utterly enchanted me. Sophie literally had me at 'bad dog'. I found myself bereft when she inevitably came into her powers. Sure this was a metaphor for self-belief (as many aspects of Hex Hall are) but I liked that she was a sucky witch.
Of particular note is the non-role of her father in her life. The issues of his abandonment were nicely played, understated even. The lack of communication between them is something that most people can connect with on some level.
Hawkins is edging towards Jennifer Echols-glory with her dialogue. It's snappy, snippy and quippy, showing the audience plenty about her characters without ever needing to be heavy handed with the telling. There's a distinct sense of teen self-awareness, bitchy humour and bravado to her voice that sits right in this reader's pocket.
As for the mythology, it is not particularly new, More like a mix of things we've all read at some point but the tone and voice allow Hex Hall to have its own sensibility. It breathes.
Hawkins' got a snappy debut on her hands with two sequels to follow. I just hope that I get to read a contemporary YA piece at some point in her writing future as I could easily see her in the Dessen, Scott and Walker mix!
Source: gift
Posted by Adele
Sophie had me at "bad dog", too. This was such a simple book and yet I enjoyed every page of it with immense glee. It's good proof that you don't need to over-complicate the plot, characters and dialogue to craft a fun story.
I agree with you on all counts, the mythology and the setting of the story have been covered in a few novels already on the shelves, and if it wasn't for the protagonist of the story, I do beleive this would have crashed and burned, much like the first scene *wink wink*.
I loved Sophie as a character, and it was mainly the narrative and her inner voice that kept me hooked as a reader. Fabulous review Adele!
Audrey (holes In My brain) said...
I won't lie, when this first came out (along with the reviews and sumaries) I was thinking, "just another paranormal... *sigh*" but after I kept reading such fantastic reviews that mirror your own thoughts, I know I have to read it one day!
Your review is so well written, I've got pretty high expectations for the book now! I could use a snippy protagonist... sulky ones are gettin gold. :D
I wasn't going to read this one. I will admit, I was kinda starting a boycott thingy, (long story) BUT having read this review I went straight to the Book Dep and ordered it :)
Mari - Escape In A Book said...
I think she lost me at sans to smexy brothers ;)
Hex Hall sounds like a fun read and one I would love to add to my TBR pile(preferably on top of it). Great review, Adele!
Annie McElfresh said...
I heart Sophie!! When she popped an internal snarky joke about Britney Spears, I was instantly rooting for her to succeed in whatever the story was going to be about!
DreamerGirl said...
Loved it and then towards the end it had a huge jaw drop i want to know what happens next...
Diva Schuyler said...
After all the angst of dystopian YA fiction I've been reading, HEX HALL is refreshingly witty with verve and sass. I absolutely loved it, and can't wait to read the next book. The ending of HEX has a nice, solid cliffhanger, making it one of the more compelling reads I've encountered in a while.
An Insult to YA Reviewers Everywhere
Persnickety Snark Question Forum
Where is Adele?
Redheads Rule!
Things I learnt from boarding school
Final List - Top 100 YA Novels (2010)
The Awesomeness of Felicity Smoak
The Problem with Felicity Smoak
Gayle Forman's If I Stay Playlist
Celebrations and Big News
Boy Next Door or Girl’s Next Bore?
The Big Trips
Archive December (1) November (1) June (1) March (1) February (1) October (2) August (3) March (2) February (1) August (1) June (2) May (2) April (2) March (8) February (18) June (2) February (4) January (4) December (5) November (2) October (1) September (1) August (2) July (2) June (2) May (1) February (1) January (7) December (7) November (5) October (5) September (1) August (3) July (1) June (5) May (7) April (5) March (7) February (8) January (11) December (15) November (15) October (18) September (30) August (29) July (32) June (17) May (23) April (20) March (14) February (11) January (30) December (25) November (12) October (34) September (39) August (28) July (26) June (46) May (39) April (50) March (48) February (28) January (37)
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PCM briefing: Boston food bank installs Viking Cold TES system; 2-day workshop on microencapsulation
Ben Welter - Friday, March 08, 2019
• The Greater Boston Food Bank is reporting a 75 percent reduction in energy use during targeted peak hours since the beginning of the year after installing a Viking Cold Solutions thermal energy storage system for the refrigeration units at its 117,000 square-foot, high-efficiency Yawkey Distribution Center.
• To mark Women's History Month, 24/7 Wall St. has compiled a list of "50 Things You Never Knew Were Invented by Women." MIT researcher Maria Telkes, a pioneer in the field of solar thermal storage, is on the list at No. 30. She created the first solar-heated system for her home in Dover, Mass., in 1947. The system used a phase change material, sodium sulfate decahydrate, to store solar heat.
• Researchers at the Chinese Academy of Sciences say they have developed an inexpensive, flexible film that renders the objects it covers virtually invisible in infrared light. The film's main components are DuPont's Kevlar, a synthetic fiber with high tensile strength, and polyethylene glycol, a phase change material that can store heat.
• French utility ENGIE has begun production at one of South Africa’s largest renewable energy projects, the 100MW Kathu Solar Park. The concentrated solar plant's molten salt storage system provides up to 4.5 hours of thermal energy storage.
• The Southwest Research Institute is hosting a two-day workshop on microencapsulation March 25-26 in San Antonio, Texas. The introductory course will cover topics such as atomization (spray drying, spray chilling, spray congealing) and spray coating (fluid bed coating, granulation). The cost is $950.
• The University of California is winning praise for its decision to end its subscription deal with Elsevier, the world’s biggest publisher of scientific journals. UC is the first major university system to push for open-access publishing. UC, which had been paying $11 million a year to Elsevier in subscription fees, generates about 10 percent of the research produced in the United States. “It’s ridiculous that, in this age of the internet, researchers are paying huge fees for access to academic papers and for publication of their own work,” the San Jose Mercury News said in a March 6 editorial.
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The Reformed Presbyterian Catechism by William L. Roberts
Minutes Of The Sessions Of The Westminster Assembly Of Divines Edited by Alexander F. Mitchell
The Zurich Letters, or the Correspondence of Several English Bishops and Others, With Some of the Helvetian Reformers, During the Reign of Queen Elizabeth (1846) by Hastings Robinson (Editor)
The Trade of Truth Advanced by Thomas Hill
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This sermon is taken from Volume 3 of SWRB's 34 volume set entitled, Puritan (Westminster, Covenanter) Fast Sermons (1640-1653).
Concerning the complete 34 volume set of Puritan Fast Sermons (1640-1653), republished by SWRB, Dr. Joel Beeke and Randall Pederson write, "This is a collection of sermons preached to England's Parliament during the glory days of the Puritan preaching on days of public humiliation... These sermons richly combine prayer and thanksgiving on England's behalf. They encourage and admonish Parliament to govern in the fear of God. The volumes include sermons of preachers who were frequently invited to Parliament, including William Ames, Samuel Bolton, William Bridge, Thomas Brooks, Anthony Burgess, Jeremiah Burroughs, Joseph Caryl, Thomas Goodwin, William Greenhill, Christopher Love, Thomas Manton, Stephen Marshall, Philip Nye, John Owen, Obadiah Sedgwick, and Ralph Venning (and many others - RB)" (from pages 632-633 of the important and useful book by Beeke and Pederson on Puritanism and Puritan books, entitled, Meet the Puritans: With a Guide To Modern Reprints).
All resources for sale on this website, with the exception of Scottish Metrical Psalms MP3s, are available on the Puritan Hard Drive .
VIDEO INTRODUCTION TO THE PURITAN HARD DRIVE
Click here to obtain the FREE PURITAN HARD DRIVE DEMO SOFTWARE!
(This free software includes over 300 Reformation and Puritan Books and MP3s, and the Puritan Hard Drive software and database!)
Click here for more information on the Puritan Hard Drive.
Download the free PDF, "How to Find Specific Words and Phrases in Searchable Books.pdf", to learn more.
The Militant Church, Triumphant over the Dragon and His Angels by Thomas Hill $5.99 $0.99
The Right Separation Encouraged by Thomas Hill $5.99 $0.99
The Season for England’s Self-Reflection and Advancing Temple-Work by Thomas Hill $5.99 $0.99
Amiable Professors Falling Short Of Heaven (Assurance) by Thomas Boston $9.99 $1.97
Annals of the Disruption (1893) Formation of the Free Church of Scotland by Thomas Brown $49.99 $4.97
The Theatre (1840) by S. G. Winchester
The Troubles of Jerusalem's Restoration, or, The Churches Reformation by John White
The Teachings of Christ In The Soul by Peter Sterry
The Trial of Antichrist, Otherwise, The Man of Sin, for High Treason Against the Son of God... (1853) by W. L. S. G.
The Trust and Account of a Steward by William Strong
The True Bounds of Christian Freedom by Samuel Bolton
The Suppressed Truth About the Assassination of Abraham Lincoln (c. 1922) by Burke McCarty
The Strong Helper or, The interest, and Power of the Prayers of the Destitute, for the Building Up of Sion by Stephen Marshall
The Subjection of Kings and Nations to Messiah (1820) by James R. Willson
The Sufferings and the Glories of the Messiah by John Brown (of Edinburgh)
The True Psalmody; or, The Bible Psalms the Church's Only Manual of Praise (1878) by Various Authors
The Spirit's Conviction of Sin by Peter Sterry
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The Christian Quotes
Image Quotes about The Christian
The government of the United States is not in any sense founded upon the Christian religion.
John Adams American President
More John Adams Quotes
The Christian Coalition of Alabama will work to ensure that reckless trial lawyers and activist judges will not be able to open the floodgates to increase taxes and that private, Christian, parochial and home-school families will be protected.
John Giles
More John Giles Quotes
The Christian Coalition will lead the way to remove the racist language in the next election.
Does anyone know...does the Christian persecution complex have an expiration date? Because...uh...you've all been in charge pretty much since...uh...what was that guys name...Constantine. He converted in, what was it, 312 A.D. I'm just saying, enjoy your success.
Jon Stewart American Comedian
More Jon Stewart Quotes
We're almost conditioned as gay people that the church means the Christian Right and the anti-gay sentiment. We don't even consider church as a possibility for us.
Jon Templin
More Jon Templin Quotes
The Pythagorean, as well as the Platonic philosophers, probably concurred in the fabrication of the Christian Trinity.
The root of almost every schism and heresy from which the Christian Church has suffered, has been because of the effort of men to earn, rather than receive their salvation; and the reason preaching is so commonly ineffective is, that it often calls on people to work for God rather than letting God work through them.
John Ruskin English Writer
More John Ruskin Quotes
Some gay rights activists have said that some conservative political organizations like the Christian Coalition, the Family Research Council and Focus on the Family are contributing to this anti-homosexual atmosphere by having an ad campaign saying if you are a homosexual you can change your orientation. That prompts people to say, 'If I meet someone who's homosexual, I'm going to take action to try to convince them or try to harm them.' Do you believe that such groups are contributing to this climate?
Katie Couric American Journalist
More Katie Couric Quotes
going to make a fool of yourself and bring scorn upon the Christian faith.
More Kenneth Miller Quotes
The Christian churches and Christianity have nothing in common save in name: they are utterly hostile opposites. The churches are arrogance, violence, usurpation, rigidity, death; Christianity is humility, penitence, submissiveness, progress, life.
Leo Nikolaevich Tolstoy Russian Thinker
More Leo Nikolaevich Tolstoy Quotes
His faith, grounded as it is in a thoughtful, reflective, and respectful approach to the Christian Gospel, enhances his ability and that of his party to approach issues in both a moral and an ethical framework.
Lloyd Mackey
More Lloyd Mackey Quotes
We caught quite a few factual mistakes, but I also looked for places where the Christian point of view was assumed. There were some and we made some changes.
Marc Stein
More Marc Stein Quotes
It's the fatal flaw in the Christian doctrine, I think. They just dropped her, and maligned her so badly, calling her a prostitute, that eventually they couldn't even see her anymore. But she's been there all along, just waiting for us to recognize her.
Margaret Starbird
More Margaret Starbird Quotes
You have the most unified Republican Party since Ronald Reagan's reelection in 1984; the Christian right is completely subdued, ... You don't have any task [at the convention] but to appeal to that prototypical woman voter who lives in the suburbs of Philadelphia.
Marshall Wittmann
More Marshall Wittmann Quotes
If I think I meet him only in Bible and sacrament, and in the Christian fellowship, then I do not know who it is I meet.
Max Warren
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It is a powerful signal that the Christian minority [can be] attacked [and] abused with impunity in Egypt.
Nina Shea
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In the Christian obsessed with "social justice" it isn't easy to discern whether charity is flourishing or faith is expiring.
Nicolas Gomez Davila Colombian Writer
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What's the Christian-bashing all about? Simple - a struggle for the soul of America is under way, a struggle to determine whose views, values, beliefs and standards will serve as the basis of law.
More Patrick Buchanan Quotes
[Ralph Reed of the Christian Coalition also spoke up for Gingrich, calling the speaker's trip to China a] cause for pride. ... We should not cave to the president's wishes and pass a budget that does not include the most sweeping tax cuts since the Reagan tax cuts of the 1980s. We need tax cuts and we need them now.
Ralph Reed
More Ralph Reed Quotes
The Christian doctrine of sin in its classical form offends both rationalists and moralists by maintaining the seemingly absurd position that man sins inevitably and by a fateful necessity but that he is nevertheless to be held responsible for actions which are prompted by an ineluctable [inescapable] fate.
Reinhold Niebuhr American
More Reinhold Niebuhr Quotes
As in the best tradition of the Christian community, death can bring a renewed sense of life. That is the case here. There is a renewed sense of respect and honor for each other, a renewed sense of honesty and friendship.
Rev. Gary Uhlenkott
More Rev. Gary Uhlenkott Quotes
Until our mission with the Christian Church is over, we must quote the Bible and use it to explain the Divine Principle. After we receive the inheritance of the Christian Church, we will be free to teach without the Bible. Now, however, our primary mission is to witness to the Christian Church.
Sun Myung Moon
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It is in the ordinary duties and labors of life that the Christian can and should develop his spiritual union with God.
Thomas Merton American
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The walls between the Christian way of life and an American way of life are basically collapsed and they're assumed to be the same thing.
More Tom Wright Quotes
There is always a pressure to separate the Bible from science and to separate the Christian religion from things material.
Walter Lang
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Quotes 1 to 25 of 50
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More Richmond News
Radio Free Richmond
Mike Raccoon Eyes Kinney: Reflecting on the Native Walk for Sobriety
By: Radio Free Richmond
As the chairperson for United Urban Warrior Society of Central California (U.U.W.S.), a National Native American organization devoted to more Human and Civil Rights for Native People, many people here in Richmond have asked me why U.U.W.S. had a Native American Walk for Sobriety this past Saturday on July 18, 2015
"I share that for the past 550 years, over 120 million Native People have been killed and slaughtered by mass extermination and ethnic cleansing. We in Indian Country suffer from historic trauma, our unresolved grief of being victims of mass extermination. Alcohol has since then become an inter-generational drug for many Natives look to escape our Historic Trauma."
Alcohol abuse affects Native American populations in higher proportions than any other community in the United States. To raise awareness of this issue, on this past Saturday, July 18, U.U.W.S. and Richmond’s Native community hosted a walk at 11 am from the intersection of San Pablo Ave & MacDonald Ave down to Nichol Park. There were over 60 sobriety Walkers that participated.
As the Lakota Holy Man John Fire Lame Deer has stated about Native People and alcoholism: " Alcoholism is a problem for us, and as long as all of this liquor is lying about, it won't get better. I have often thought about the special effect liquor has on us Indians. In 200 hundred years, we still haven't learned how to handle it. It's just like the measles and other diseases the white man brought us. The illness was the same for them as for us, but we died from it."
Many Native people, families and communities are now forming organizations to deal with the issues of alcoholism and alcohol abuse, such as 'Walking the Good Red Road' and ‘Wellbriety.' The return to our traditional spiritual beliefs and values helps us to lead lives free of alcohol, and Native Sobriety walks are crucial in raising awareness surrounding the issues of alcoholism and alcohol abuse in the Native communities
Historically, Indian Country has always had social marches throughout the U.S. to bring awareness to mainstream society to better educate them about our conditions and how we were living both then and now. Native Sobriety Walks are a direct outgrowth of that.
The Native American Walk for Sobriety here also represents healing for our families and community that has been ripped apart and destroyed by alcoholism and alcohol abuse. It really represents a time for healing, where we as Native People can stand tall and take control of lives and destinies, and lead our lives alcohol-free.
Native Americans have historically had extreme difficulty with the use of alcohol. Problems continue among contemporary Native Americans; 12% of the deaths among mainland and Alaska Natives are alcohol-related. A survey of death certificates over a four-year period showed that deaths among Indians due to alcohol are about four times as common as in the general US population and are often due to traffic collisions, liver disease, homicide, suicide, and falls.
Native American youth are far more likely to experiment with alcohol than other youth, with 80 percent reporting alcohol use. Low self-esteem is thought to be one cause. Active efforts are underway to build self-esteem among youth and to combat alcoholism among American Indians. So Native People Walking for Sobriety is one of the ways that the Native Community addresses the clear and present dangers of alcoholism and alcohol abuse.
The most important goal of the Native Walk for Sobriety is the ideas of self-empowerment, self-worth and self-esteem. For too long many Native communities and Nations had remained silent yet to speak out on the REAL problems and issues of why Native People drink. We in the Native Community know how important it is for we as Native People to set positive and spiritual examples to our high-risk teens and young adults.
The Native Sobriety Walk was organized by many Community leaders through out Richmond because of the issues surrounding alcohol abuse and alcohol abuse. City Council member Vinay Pimplé, was one of our Sobriety Walkers and he stated: " Our kids are exposed to the glamorization of alcohol and no one talks to them about alcoholism. They are exposed to advertisements in the media about alcohol unaware of the dangers from drinking. This Walk was a positive
image for our community see by the Sobriety Walkers being out there that day!"
Another Community leader of the Sobriety Walk Amrik Pannu of the Sikh Guruwada Sahib (Temple), noted that:
"The Sikh Faith totally prohibits the use of alcohol, drugs or tobacco. We in the Sikh Faith wish to help anyone in the community trying to make a difference when it comes to issues such as alcohol. When people come to us at the
Guruwada (Temple) and ask for our help, we will be there to help them. We Sikhs are advocates for helping the community for more Human and Civil Rights." (Mr. Pannu was responsible with other members from the Guruwada (Temple) for bringing refreshments to the Sobriety Walkers at Nichols Park and members from the Sikh community were Sobriety Walkers as well.)
Jerome Smith another Community leader of the Sobriety Walk shared: " There is no sobriety without doing it! A Sobriety
Walk is doing it. It shows the value and importance of sobriety to the entire community." At the beginning of the Native Sobriety Walk at of the top San Pablo and Macdonald Avenues shared a Haiku poem on sobriety to the delight of our sobriety walkers: "Sobriety. A Wolf Howls, a Bear Growls, Now Wandering the earth."
Kay Kay Kinney (Apache) another Community leader and U.U.W.S. member felt: "The Sobriety Walk was formed to bring about the much-needed awareness in the Native community. Alcoholism is a disease and a negative aspect in one's life. There is nothing positive about drinking alcohol. It kills and is NOT a joke! The importance of the U.U.W.S.-Central California Native Walk for Sobriety is the awareness and support for all those fighting the disease!"
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Defendants in case over illegal referendum to spend up to 4 years in prison
Moscow court finds defendants in case of illegal referendum guilty of extremism
Sentencing of alleged masterminds of unlawful referendum set for August 10
Prosecutor demands 4-year jail term for alleged organizer of unlawful referendum
© Fotolia/ Africa Studio
Tags: Sentence, Extremism, Moscow's Tverskoy District Court, Moscow, Russia
MOSCOW, August 10 (RAPSI, Oleg Sivozhelezov) – The Moscow Tverskoy District Court has sentenced four members of the Initiative Group to Campaign for a Referendum for Responsible Government to terms varying from probation to four years in prison for organizing an extremist group, RAPSI correspondent reported from the courtroom on Thursday.
Earlier today, the court found journalist of the RBC news agency Alexander Sokolov, publicist Yury Mukhin, civil activists Kirill Barabash and Valery Parfyonov guilty. Sokolov was sentenced to 3.5 years in a penal colony, while Barabash and Parfyonov were sentenced to 4 years in jail. Mukhin received a 4-year suspended term and additional 4 years of probation.
The defendants are indeed members of the Initiative Group to Campaign for a Referendum for Responsible Government, which, the authorities believe, is the successor of earlier banned People’s Will Army (PWA), Mukhin told RAPSI. However, the action group aiming to organize the referendum was established yet in 2010, he said.
Sokolov, Parfyonov, and Barabash are charged with continuing to run the prohibited in 2010 People’s Will Army, earlier headed by Mukhin. After the PWA was banned, the accused founded the Referendum Initiative Group seeking to make the authorities directly answerable to the people through changing the country’s Constitution.
Nevertheless, the prosecution says that in fact Mukhin and his supporters have attempted to destabilize the political situation in Russia and accomplish a regime change with illegal means.
In 1995, Yury Mukhin, a proponent of radical change, founded the Duel newspaper, which attempted to reach out to Russian conservatives and far left. The newspaper was banned in 2009 on grounds of extremism.
15:00 10/08/2017 The Moscow Tverskoy District Court has sentenced four members of the Initiative Group to Campaign for a Referendum for Responsible Government to terms varying from probation to four years in prison for organizing an extremist group.
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Scots comedian Kevin Bridges adds extra date to debut Australian tour
THE Glaswegian comic kicks off his tour Down Under next month with shows in Perth and Melbourne before ending in Sydney at the end of April.
Kevin Bridges live At The Apollo
SCOTTISH comedian Kevin Bridges has added an extra date to his debut Australian tour, which starts next month.
Bridges, who will play at total of 27 shows during his tour of Down Under, kicks off with a performance at Perth's Aston Theatre on 20th March before heading onto The Melbourne Comedy Festival from 27th March until the 20th April.
The 27-year-old had previously tweeted: "Perth sold out, working on an extra date. Really appreciated and looking forward to getting down to Oz! Cheers again."
His final show will be at Sydney’s Factory Theatre on the 22nd April.
Watch the comedian's hilarious sketch on life in Glasgow on the video below.
Check out our list of the funniest Scottish videos on the internet.
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by Julio Gutierrez - Blogging - January 15, 2020
Zombies are not just within the large display screen or your tv display. Killing zombie video games are also now famous as video video games and in other game consoles. While some human beings make these fun zombie video games a part of their daily gaming habit, there are folks who best care for the exceptional killing zombies video games 사설토토사이트.
What are the first-class new zombie video games
A zombie killing sport is best as excellent as the user evaluations. Feedbacks are thus very crucial for these games. Check out the top 10 new zombie games for anybody who loves these creepy flesh-eaters:
1). Left 4 Dead 2
This zombie recreation, which became created together with the discharge of Left four Dead, is available in Mac, Xbox 360 and PC. Zombie hunters will allow you and your pals to combat hordes of those living corpses until you reach the extraction factor. Make certain you do not stray faraway from the group if you do not need to be strangled or picked up by a zombie.
2). Red Dead Redemption: Undead Nightmare
This game from Rockstar is available in Xbox 360 and PS3. See the undead within the Western World as the zombie hunters use new ammo and guns taken from the zombie’s bones.
Three). Plants vs. Zombies
Everyone can enjoy this recreation as it is to be had in iOS Android, Xbox 360, PS3 and PC. Who could have thought that plants may be the first-rate guards against the flesh eaters? However, these are no ordinary zombies due to the fact apart from taking a ramification of shapes and sizes, they are also prepared to shield themselves the usage of something tools inside smooth reach.
Four). Resident Evil 4
This recreation will will let you use your excellent weapon towards the killer corpses through your Wii, Xbox 360 and PS3. Spain ought to were a romantic town however no longer in Resident Evil where it’s miles filled with evil creatures.
5. Dead Island
This sport is to be had in Xbox 360, PS3 and PC. Be one of the survivors that have landed on Dead Island. However, you’ll start to marvel if you have clearly survived after you recognize that you are in the company of the undead.
6). Dead Nation
This recreation will prove that the zombies can by no means be defeated because even in case you shoot them all down, they may just stand and hold coming again to you. However, this recreation is to be had best in PS3.
7). Dead Space 2
This sport is to be had handiest on PC. The diehard fanatics will argue that whilst the corpses here have resurrected, they are now not surely zombies. To kill them, you have to dismember and decapitate them.
Eight). Call of Duty Zombies Saga
Since it is available in Xbox 360, PS3 and PC, this sport offers you lots of possibilities to slaughter as many zombies as you could
9). Dead Rising 2
The game is to be had in Xbox 360, PS3 and PC. More importantly, it gives you the threat to peer as many as 7,000 flesh eaters simultaneously on the display and kill them the use of weird weapons.
10). The House of the Dead: Overkill
This sport is to be had in Wii and PS3 but isn’t always encouraged for very younger kids due to the violence and the sexual content.
These games will keep you in your feet for a long term however do be careful for the brand new zombie games that allows you to honestly be launched one after the other.
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Swedish Institute for Drug Informatics
Open and independent drug information and tools, accurate and reliable, for the benefit of all.
Open Access Week October 21-28
The Open Access Week 2012 will be held 21-28th October. Events can be attended either physically all over the world or by Internet. For more information see...
Medical and academic leadership is needed for clinical decision support systems.
In a medical comment in Läkartidningen, Lars L Gustafsson, describes the rationale of using good decision support practice when developing and implementing clinical decision support...
Vinnova supports the development of open data sources
VINNOVA, the Swedish Governmental Agency for Innovation Systems has announced a call for proposal for open data sources. The aim of the call is to support the start of new innovations by making...
Comparison of drug-drug interaction systems for both pharmacy and health care
The journalist Fredrik Hedlund describes competing decision support systems for
drug-drug interaction control systems in Swedish healthcare and for dispensing of drugs at pharmacy
Video recording of the eSPC Workshop at EMA
On October 5, took place in London a workshop within the project electronic SPC (e-SPC). e-SPC is a cooperative project between the EMA and the Karolinska Institute. The meeting was chaired by Dr...
New Project: Swedish reference model for drug information
SIDI is launching a new project based on the preliminary work from Seibo Software Studios:...
Unique evaluation of two drug-drug interaction databases for expert support in healthcare and in pharmacy
by Prof. Dr. Lars L. Gustafsson
A few days ago Swedish Medical Products Agency (MPA) published a unique comparison of two drug-drug interaction databases called...
PRESS RELEASE 2011-06-14
New Swedish institute to promote free access to reliable information about medicines
Printable pdf:...
SIDI's site is launched
As a first step in SIDI's life its website is launched! We hope to develop it as an important tool to communicate our message and to keep the Foundation in touch with its audience.
The Foundation is approved
2011-05-11 - The County Administrative Board of Stockholm (Länstyrelsen i Stockholms Län) registered Swedish Institute for Drug Informatics (SIDI) as a Foundation in its Register of...
Prof. Dr. Lars L. Gustafsson
Lars L Gustafsson is professor and senior consultant in clinical pharmacology at Karo- ilnska Institutet and at Karolinska University Hospital in Stockholm, Sweden. Lars is active in research, edu- cation and in development projects within the area of clinical pharmacology and drug infor- matics. He collaborates with researchers, physicians and IT-specialists in Sweden, Europe, Africa and globally. [more ...]
Lars think that: "SIDI will make a difference! Independent drug information will be reachable when you need it in healthcare and as a patient across the globe."
Dr. Ylva Böttiger
Ylva Böttiger, senior consultant and asso- ciate professor at the Division of Clinical Pharmacology, Karo- linska University Hos- pital, head of the Karolinska Drug Information Centre and di- rector of studies of Clinical Pharmacology within the Karolinska Institutet. [more ...]
Dr. Filippa Nyberg
Filippa Nyberg is a dermatologist, PhD and Chief Executive Officer for the Swedish Society of Medicine. Filippa became a member of the Board of Directors in December 2012.
Computer Scientist Daniel Rodriguez
Daniel Rodríguez is a senior software developer and technical manager. He has an extensive experience in developing systems in the health care sector, particularly in terminological knowledge bases and drug informatics
"... patients, physicians and health care in general will gain a lot if drug information sources are freely available and easily accessible."
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A few days ago Swedish Medical Products Agency (MPA) published a unique comparison of two drug-drug interaction databases called EES (Drug-Drug interactions in the Electronic Expert Support provided by The Information Service Board for Swedish Pharmacies) and SFINX http://www.lakemedelsverket.se/Alla-nyheter/NYHETER-2011/Utvardering-av-interaktionsmodulerna-SFINX-och-EES-/)
The Drug-Drug Interaction Function in EES is originally developed by the US Company First Databank and intended to be used as an Electronic Decision Support for pharmacists when dispensing drugs at pharmacies. SFINX is developed primarily for use as a decision support system for physicians and nurses in drug prescribing by clinical pharmacologists and pharmacists at Karolinska Institutet in Stockholm, at the Finnish Company Medbase and by experts at Stockholm Healthcare Region (1-3).
The responsible officer for the evaluation is Anders Carlsten in collaboration with internal and external experts at Swedish Medical Products Agency. The Swedish Ministry of Health has ordered this comparative study (http://www.regeringen.se/content/1/c6/16/50/49/374dd647.pdf ). This is initiated by discussions in Sweden about risks to have two different knowledge databases for drug-drug interactions but also a firm commitment by the Minister of Health to provide a number of EES functions not only at pharmacies but also at Swedish healthcare institutions (www.lakemedelsvarlden.se/zino.aspx?articleID=13916). It is quite amazing that this comparison between EES interaction function and SFINX was initiated by a Ministry led by a politician, Göran Hägglund, and not by the National Board of Health and Welfare (www.socialstyrelsen.se) in charge of providing Swedish Healthcare Institutions with guidelines on best practices.
The evaluation is in Swedish but of great interest for everyone interested in how healthcare staff should be supported with scientifically based advice at point of care in future. The evaluation recommends SFINX to be used preferably as decision support in pharmacies and in healthcare institutions . The advantage is that SFINX has drug-drug interaction alerts based on each substance in comparison with the EES drug-drug interaction function that mostly has shared drug-drug interaction alerts for a class of drugs. In addition, EES drug-drug interaction function lacks information for about 22% of available drug substances in Sweden. Dr Anders Carlsten also comment that it is not optimal if two different knowledge databases with different classification systems (3 for EES drug-drug interaction function and 4 for SFINX) are used simultaneously in the country.
A thrilling time is in front of us. The intention from the Minister has been to provide the whole contents of EES, including the drug-drug interaction function, to all Swedish physicians (www.lakemedelsvarlden.se/zino.aspx?articleID=13916) but this evaluation recommends SFINX to be used at all pharmacies in Sweden. How will the decision be taken on what drug-drug interaction database should be used be used electronically at point of care and at pharmacies when dispensing drugs in Sweden? Is the minister to take the decision or is it the National Board of Health and Welfare making the decision based on recommendations from their scientific experts? I do hope that the evaluation of MPA is published in English. This evaluation shows that the question on what knowledge databases should be used in healthcare is hot. In my mind, it is self-evident that we only need knowledge databases that are based on scientific findings and developed in an open matter and freely available in the public domain. The risks to use different drug-drug interaction information in pharmacies and in healthcare institutions in the same country is not known but is likely not negligible.
1. Tillgängliggörande av EES för vårdgivare. Rapport: Utvärdering och införande av ESS. 2011-03-17. Apotekens Service AB.
2. Böttiger Y, Laine K, Andersson ML, Korhonen T, Molin B, Ovesjö ML, Tirkkonen T, Rane A, Gustafsson LL, Eiermann B. SFINX-a drug-drug interaction database designed for clinical decision support systems. Eur J Clin Pharmacol 2009;65:627-33 ( http://www.ncbi.nlm.nih.gov/pubmed/19205683).
3. Eiermann B, Bastholm-Rahmner P, Korkmaz S, Lilja B, Veg A, Wettermark B, Gustafsson LL. Knowledge databases for clinical decision support in drug prescribing- development, quality assurance, management, integration, implementation and evaluation of clinical value. Decision Support Systems, Book edited by: Chiang S. Jao, ISBN 978-953-7619-64-00, January 2010, INTECH,
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Drugle is a search engine specialized in drug information.
You can test Drugle here or read about it here.
INTERNATIONAL EXPERT WORKSHOP IN STOCKHOLM JANUARY 24-25, 2019
BIKT nominated for the award Guldpillret
SIDI co-organises meeting about medical information
BIKT agreement
SIDI at Vitalis
Swedish Research Council publishes a proposal for Swedish guidelines for open access to scientific information
Internet Infrastructure Foundation publication about the Drugline project
Drugline, online for more than a year.
Drugline launched
Seibo Software Studios
Piperska Group
[more links ...]
e-SPC delivering drug information for the 21st century
Responsability for comprehensive drug list ... (Swedish)
European Medicines Agency (EU)
Medical Products Agency (Läkemedelsverket, Sweden)
Janusinfo, Medicinskt Kunskapscentrum (Sweden)
SIL (Sweden)
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Welcome to the May 2008 Edition of the Stephen Johnson Photography Newsletter. We hope you enjoy this edition.
Our BIG NEWS is our Spring Gallery Discount Sale of 40% off original prints. Running through June 14, we are offering our gallery wholesale discount to all buyers.
We have many new exciting trips and offerings this month. There is also a new podcast up.
The months offerings include the new Digital Black and White Photography Hands-On workshop from May 15-18, 2008. Also because of many inquiries, we have scheduled an additional section of our much in demand Fine Arts Digital Printing Hands-On workshop for May 24-27. Both of these workshops are held in our beautiful Pacifica studios. If you haven't taken a course with us, May is a great time to acquaint yourself with our stunning coastal town.
We are very excited about our Ireland's Spectacular West Coast workshop in June 20-30 has a few spots available. This is THE workshop to bring your family or partner. We'll be exploring western Ireland, the Burren, the Aran Islands, going to castles and cliffs, ancient stone structures and family pubs. It's a perfect opportunity to share your passion for photography with other people in your life. Helicopter flights have now been added to the experience!
Summer and Fall workshops include the popular From RAW to Print: Summer Digital Boot Camp, Zion National Park, and Yosemite in the Fall. Our Maine Media workshops still have some space so check out The Digital Landscape and Fine Art Digital Printing in Rockport Maine during early August. The first 2009 workshop is up, Death Valley in Winter.
Iceland in July! The long days, the colorplay of ice, volcanism, greens and shimmers of white merge in the short summer months. Join us for our first Iceland Workshop for the last week of July.
Castles and Clouds. Chisos Basin. Big Bend National Park. Texas. 1997.
Our workshops are designed to enhance your photographic talents and skills. Tell us about your needs, talk to us about photographic destinations. This is continuing new program of letting people request the workshops they want. Email the Workshops Currently Building List so we can build a list of people and determine dates.
Great teaching, great facility.
What more could you need for the plunge into digital photography?
...Big Print Sale
...New Ted Orland Poster
...Al Weber book
...Art and Fear
...GrayCaps
Featured Print Offer
...Volcanic Wall. Mt. St. Helens
...Thoughts on Photography Books
The Digital Book
...SJohnson on Digital Photo
...Fine Art Digital Printing
...Digital Black and White
...From RAW to Print Bootcamp
...Zion
...Yosemite in the Fall
...Death Valley in Winter
...Maine Media Workshops
...Canon Lectures
...New England Camera Club Conference
...Iceland Landscape Mastery Workshop
...podcasts
...book reviews
...Epson Printers no longer used
...Stephen Johnson Editions
...Portraits
...Newsletter Subscription
...Newsletter Archive
Big Gallery Discount Print Sale
Our BIG NEWS is our Spring Gallery Discount Sale of 40% off original prints. Running through June 14, we are offering our gallery discount to all buyers. This is strictly limited to our cut-off date of June 14, but applies to all original works over 16x20 in size. This is also accompanied by a price increase on original prints that will be in effect as of June 15, with most works going up about 20-40%.
Details and Open House on Saturday June 14.
Ted Orland's New Photographic Truths Poster. 24x36 inches. $20.
An underground classic, gracing the walls of university darkrooms and professional studios alike. But now (finally!) it’s available again in a new edition — still illustrated with the same friendly picture of Ansel Adams, but with a text that now includes many newly-discovered digital truths.
Advice for Photographers: The Next Step
by Al Weber
2007. $12
Based on decades of teaching, Weber has collected and organized ideas and suggestions to aid those who would be photographers. A 72-page field manual.
Art and Fear
by Ted Orland and David Bayles
1993. $12.95
A terrific book. A must read for every artist who has struggled with working, creating, reaching out and hanging in there.
GrayCapsTM Digital gray card. The Digital gray card you will always have with you, even among 10,000 penguins.
Volcanic Wall. Mt St Helens. 1995
11x14 Pigment Print on Rag paper
This pattern of erosion and oxidation on northeast wall inside the crater on our September 1995 climb.
We're offering an 11x14 inch print, matted to 16x20 and ready to frame for $195, framed for an additional $75. This print at this price is offered through May 31. We'll be taking orders until then, and shipping them out by June 15th.
Each month we offer a signed, original print, at a special price. This is a great opportunity to own a very affordable fine-art photograph. Orders are taken for a 30-day period, then printed and shipped within two weeks after the close. When it's over, it's over, these prints won't be available again at this price.
Thoughts on Photography Books
Can a book sell for between $65 and $100 and be a success in today's publishing market? Even with what may be a long-anticipated book like my work on the national parks, With a New Eye, this is an important question. That is exactly the question we are grappling with as we finish the book for publication.
With a New Eye: Stephen Johnson's Journey through America's National Parks is a 256 pages 12x15 documentation of my large-format digital work in the national parks over the last 10 years.
The book was intended to be published in 2007 but some editing delays pushed us into 2008 and subsequently into a depressed worldwide economy and rather poor Euro to Dollar exchange rates. The exchange rates are important as we had tested reproductions with the same Italian printer we used for Stephen Johnson on Digital Photography, LEGO near Venice. Of course, my goal was always to print the book in America, but costs have simply been too high. I am firmly convinced that there is no higher quality printing than can be had in the United States.
The sheer costs of high-end photographic book reproduction is the steepest hurdle to overcome. Press time costs and prep are expensive, but today high-quality paper is likely to account for about 60% of production costs.
There are many who say that the day of the printed page is nearing an end. Certainly big photo books have to struggle into existence and are often quickly remaindered to wholesalers at less than cost of production. Few photographers make any real income on their books, regardless of effort expended or beauty contained.
Some artists are addressing the problem by opting out of the publisher/printing press scenario and self-publishing, going to print-on-demand options like Apple iPhoto books, Shutterfly, Lulu or mpix with high-end color laser printed generically named digital presses. Although the quality is not as impressive as high quality conventional offset printing, it can be quite good and might well be suitable for many projects. My friend Douglas Holleley has published a number of thematic explorations of ideas and images in this print-on-demand model. As Douglas points out, good on-demand digital press work can often be better than run of the mill offset.
My Pt. Lobos workshop last weekend had the unique privilege of visiting with my old friend Al Weber in his Carmel Highlands Studio. One of the interesting conversations came round to books, ownership, royalties and size. Al pointed out that another way of dealing with some of these challenges is to go small, into intimate books that may lack size but pack the real world impact of being able to be much more affordable to produce and to purchase. Los Angeles photographer Doug Busch is doing a series of smaller books along this line that are doing quite well.
Self-publishing smaller text-based books is easier, and with good content can be quite successful such as Ted Orland and David Bayles' Art and Fear from their Image Continuum Press and the very recent Advice for Photographers: The Next Step by Al Weber. Robert Adams' Beauty in Photography remains one of my favorite photography books, is not large and has very few illustrations.
The Parks Book
So, here I am trying to do a traditional large-format coffee table type book, except with much higher than normal reproduction values and in an oversize horizontal format. Why?
A project-based photographic book is a culmination of sometimes years worth of work. It is a bringing together of the ideas into a single place, a permanent record of intent, hopefully a record of achievement that becomes an accomplishment in its own right.
The parks project was based on a reaction to the remarkable quality that a large-format scanning camera could deliver. It was, in many ways, a staking out of determination that this could be done. With virtual contact-prints of 20x24 inches, it was always clear that any book would have to be a reduction of the impact of the original work. For a very long time I mulled over what this book might be. As I started to design the book, it became clear that a large book would be critical, as large as one could conceivably hold. It was with that consideration in mind that I choose O'Reilly, a publisher willing to help create just such a volume.
The current book specs call for the 25 inch wide images to be reduced to about 13 inches to fit into the book. This still makes for a massive volume. In 2003 we made a 12 page sample of what the book could look like. It won many people over to the beauty and potential of the book. In 2004 a full-sized full-length copy was created on the Hewlett Packard Indigo digital press, helping dramatically in securing our publishing arrangements.
These desires and plans do not change the present economic challenges facing this book. Under such circumstances, it is hard to know exactly what to do. Some have argued for a delay until optimism returns to the country. More delays in an already long overdue book seems like a poor choice. Some have suggested a smaller book, more in keeping with current economic realities. Others have suggested simply waiting until next year when we hope the economy improves.
Challenge and Opportunity
An inherent challenge and opportunity is embedded in the parks project. The challenge is money, distribution and some reasonable measure of market interest intermingling with the first two.
How many of you will pre-order a $95 hardbound copy? A $65 softbound edition? How many of you would be interested in what we believe to be an historic limited edition with an original print for $500?
These are real questions we need help with. Please email us. info@sjphoto.com
Additionally, other than through traditional book distributors, do you have contacts where the book might be carried and handled appropriately?
There are also huge opportunities associated with this project. New ways of seeing the parks, new ways of making photographs, art and technology intersecting at the leading edge of a new era of imaging technology. There are ultimately new photographic products that can come out of the project as well. Some already exist.
Parks Project Products
Let us know your thoughts.
Order Now for a signed copy!
Professional Photographers of America 2007 Hot One Awards
Stephen Johnson on Digital Photography
Book Comments online
* Upcoming Workshops
The Digital Lab at Stephen Johnson Photography
We trust you find our selection of classes interesting and useful for your needs. We take the imparting of information and the empowerment of our students quite seriously. The digital age has considerably enhanced our ability to teach, and we believe, your ability to capture what you see. This program is designed to help you benefit from both of these advances.
We hope you can join us on a workshop.
We are also starting a new program of letting people request the workshops they want. Check out the Workshops Currently Building List and help us build a list of workshops and people so we can then determine dates. See the workshops page for a list of previously offered classes that we would be happy to teach when we have enough people.
Fine-Art Digital Printing Hands-On
Stephen Johnson Studios & Gallery
Pacifica, California.
This workshop focuses exclusively on improving your fine-art digital printing in our new Digital Lab, primarily using Epson inkjet printers. Concentration will be on inkjet printing with color pigments and black/gray ink combinations on coated and rag papers. Learn from the digital pioneer how he obtains his impressive results during four days of lectures, printing, and feedback in the studio.
We will cover workflow issues, color management, correcting color casts, adjustment layers, custom profile generation, editing and inspection. There being no magic bullet to making good prints, the workshop will also explore old fashioned testing, careful color judgments and interactive honing in on the best print possible.
Digital Black and White Photography Hands-on: Scanning, Conversion and Printing
Explore black and white photography in the digital age from file creation to print with a classical landscape photographer who comes from the world of large-format black and white.
Steve has maintained his deep love of black and white photography while leading the transition into digital photography. His digital black and white work dates back through 1992 with the Kodak DCS 200, the Leaf DCB and later through the BetterLight, Kodak dedicated BW cameras and the Foveon BW mode.
Steve's use of custom Iris inks, gray inks for Epson printers and development work on the new HP Z3100s black and white modes shows a long-term interest in bringing BW into the mainstream digital world.
Ireland’s Spectacular West Coast
Join Stephen Johnson and Anthony Hobbs for an unforgettable journey along the rustic West Coast of Ireland. This workshop will include hotel stays in several towns along our route from County Clare towards Achill Island. Along the way, participants will explore western Ireland's landscape with its rugged coast, lush greens, rocky islands, lake-filled valleys and remote castles.
Irish culture and history will also be part of this trip as we visit key locations and provide natural and human history discussions along the way. Some Gaelic language lessons and Irish folk arts performances might also be picked up on our travels along with the warmth and friendliness of the Irish people.
From RAW to Print in One Week
Summer Digital Boot Camp
An intense immersion into digital photography with one of its pioneers. In five days you will go from perhaps not even understanding what a RAW file is, to making well-crafted and thoughtful prints. Some fieldwork and extensive lecture and lab work will fill our time together. Every student will have full access to their own workstation in our lab. Topics include practical experience with digital exposure, RAW processing, image editing, color management and printing.
Included in the workshop is a copy of Stephen Johnson on Digital Photography, courtesy of O'Reilly Media.
August 30-September 1, 2008
Join us on a three-day adventure through the visual wonderlands of southern Utah's Zion National Park. The trip is designed to be a complete immersion into landscape photography and its digital evolution with the pioneer in digital landscape photography. Extremes of brightness and shadow, distance, haze, perspective and form can make Zion a real challenge to photograph, but are at the heart of its beauty as well. Thoughtful seeing and good use of digital tools assist greatly in this process, and the workshop will emphasize those aspects of digital imaging and processing for which this location creates such a unique need.
We'll work on creating photographs which succeed in carrying some feel of what is special about this place with a visual integrity that speaks to you. The place was named "Zion" as a sanctuary by the early settlers, and was a holy place to the Native Americans before that. Zion is more than just a scenic national park; it is at once wild and unknown to most visitors, while at the same time managing to be comforting and intimate, becoming nature at its most intriguing. If you haven't been to Zion, imagine huge rocky outcrops, similar to Yosemite, but much closer together. There are towering red sandstone cliffs accented by pines and chartreuse cottonwood foliage; mossy seeps and creeks; sandstone in every color from mustard to raspberry, eroded into sensuous forms; petrified dunes with their layers, angles and striations; aspens, slot canyons, slickrock, sage; wide views and precious details.
Infusing your reactions to all this into your photographs will be the second focus of the workshop.
Yosemite Valley in Autumn
The fall colors of Yosemite offer photographers a wide variety of hue and texture. As the weather cools, the valley begins to change, subtle and beautiful colors start to emerge. People begin to disappear, bright greens turn to browns, yellows, blacks and golds. The valley smells fresher, the air clears and invites the walking we will be doing during this workshop. We'll spend four activity packed days in the valley, sometimes rising before dawn and lingering for the last moment of twilight.
The trip is designed to be an in-depth landscape photography workshop in the context of this digital age. We will discuss technical and aesthetic issues, tapping into your emotional response to this landscape, working toward images that are uniquely your own.
Death Valley in Winter
Transformed from a searing 120 degree desert in summer to January's mild 60-70 degree weather, Death Valley is filled with intriguing landforms, delicate flora, strange mineral deposits and expansive views. Mile high Dante's View overlooks the patterned salt flats of Badwater and the Amargosa River below (the lowest point in the United States). Badwater's still water in turn mirrors the blue and white Panamint Mountains to the West. The lunar landscape of Ubehebe Crater's black volcanic fields rise from the rolling desert at the valley's north end with the steep gorge of Titus Canyon and Red Pass to the southeast.
Personal Workshops and Art Consulting
Arrangements can be made to work with Steve individually at his studio or at custom locations. Call for a discussion of the possibilities. 650 355-7507
Steve and Tom
Olympic Peninsula, 2002
* Check out our workshop web page for information on all of our workshops, including both our field and studio workshops.
UPCOMING EVENTS with Stephen Johnson
Maine Media Workshops
The Digital Landscape. August 3-8, 2008
Fine Art Digital Printing. August 10-16, 2008
Iceland: Mastery of Landscape
Canon's Explorer of Light Photographer - Stephen Johnson
Photographer Lecture Series
Stephen Johnson Talk
Adobe Technology Exchange of Southern California
Saturday, July 19, 2008. 9:00 AM to 12 noon
Location of event: Toyota USA's headquarters at the corner of 190th street and Gramercy Place in Torrance, California
New England Camera Club Conference
Friday through Sunday, July 11-13, 2008
RECENT INTERVIEWS, ARTICLES AND PUBLICITY
O'REILLY podcast
MacVoices Podcast
MacEdtion Radio
DIMA Podcast
Photoshop World Podcast
Photoshop World: March 2008 Interview
Printers I'm no longer using. Make an offer. Must pick up.
Epson 5500 (with lots of ink supplied)
Epson 9000 (dye inks and Lyson grayscale set included)
Printers being replaced:
Epson 2200 $300
LAB RENTAL SERVICES
We are now offering rental time in our new lab on an hourly basis during our normal business hours.
Tuesday-Friday 10am to 5pm.
$25 per hour, plus a per print charge
Includes full access to calibrated monitors, fast G5 Macs, Epson pigment inkjet printers, 5000°k viewing lights and color profile creation hardware and software.
Appointments can be made by calling 650 355-7507.
Familiarity with Mac OSX and Photoshop CS2 or 3 or Adobe Lightroom recommended. Staff tutorials available for additional charge.
A Great Opportunity!
Fully equipped lab
Make your own printer profiles
Finally have access to the equipment you need
Digital Portraits by
The Studios of Stephen Johnson Photography
Instant Feedback
Satisfaction or no fees
Stephen Johnson Editions
watercolor by Ralph Putzker
To purchase original prints, see:
• 11x14 pigment on rag paper $450 from existing prints
•Information on Stephen Johnson's Original Prints
•With a New Eye: The Digital National Parks Project
We're happy to mail you a copy of our product catalog, just send a note to michelle@sjphoto.com or call us.
Map to studio
To subscribe to the sjphoto-news mailing list
web: http://sjphoto.com/mailman/listinfo/sjphoto-news
Last updated on 5/28/08. Mail comments to: info@sjphoto.com
Photographs and Text Copyright ©2008, Stephen Johnson. All Rights Reserved Worldwide.
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Alderwasley Hall Sixth Form Centre
Title: Alderwasley Hall Sixth Form Centre
Subject: Brooksby Melton College, East Northamptonshire College, Chesterfield College, South East Derbyshire College, Tresham College of Further and Higher Education
Collection: Education in Derbyshire
1993 (As Callow Park College)
Alderwasley Principal
Angela Findley
Nyree Parker
DE4 4BN
Alderwasley Hall Sixth Form Centre is a Private special needs sixth form college located 1 mile south of Wirksworth in Derbyshire it is part of Alderwasley Hall School, previously a country club named Callow Park after the nearby village of Callow which is about a mile, the site was re-branded to its current name in 2012. The Ecclesbourne Valley Railway runs next to the site.
Country Club 1
Use as a School 2
Specialisms 2.1
Alderwasley Hall Sixth Form Centre was previously a county club called Callow Park with several Squash courts, a small swimming pool, 2 outdoor tennis courts and rooms for visitors to stay the night
Use as a School
in 1993 the site closed and became part of Alderwasley Hall School and was converted into a school. Callow Park is for students aged sixteen to nineteen and for younger students when studying for Art and PE. Many of these students also attend nearby colleges such as Ilkeston and Buxton on a part-time basis. Some of the students live at the site while many day students attend from nearby areas. Despite being a Private College the majority of funding comes from local education authorities (lea).
It is owned by the SENAD Group based Derby who run other schools children and young people with learning difficulties.[1]
The site changed its name on September 1st 2012 to Alderwasley Hall Sixth Form Centre.[2]
Callow park is Primarily for Asperger's Syndrome and speech and language difficulties, but does take students with Autistic Spectrum of Difficulties, Dyslexia, Specific Learning Difficulties, Social Emotional and Behavioural Difficulties, Delicate/Medical Conditions, Epilepsy and Dual/Multi-Sensory Impairment [3]
^ SENAD group
^ "Callow Park College is Changing its Name". Retrieved 18 October 2012.
^ Isbi Alderwasley
Alderwasley Hall School
Universities and colleges in the East Midlands
Further education colleges
Brooksby Melton
Central College Nottingham
New College Nottingham
North Nottinghamshire
Riseholme
South Leicestershire
South East Derbyshire
New College Stamford
Vision West Nottinghamshire College
Sixth form colleges
Bilborough
Gateway College
East Northamptonshire
Regent College, Leicester
Wyggeston and Queen Elizabeth I
Special Needs Colleges
Portland College
RNIB College, Loughborough
Education in Derbyshire
East Midlands school stubs
Derby, Staffordshire, Chesterfield, Greater Manchester, Cheshire
Lincolnshire, United Kingdom, Northamptonshire, Rutland, Derbyshire
BPP University, National Union of Students (United Kingdom), East Midlands, University of Dundee, Rugby union
University of Cambridge, England, Imperial College London, Durham University, University of Edinburgh
Leicestershire, East Midlands, Loughborough University, University of Nottingham, Melton Mowbray
East Northamptonshire College
East Midlands, Loughborough University, University of Nottingham, East Northamptonshire, Rushden
Chesterfield College
Derbyshire, England, East Midlands, Loughborough University, University of Nottingham
South East Derbyshire College
Derby College, Ilkeston, Plutonium, Keele University, University of Bristol
Tresham College of Further and Higher Education
Northamptonshire, England, Kettering, Wellingborough, De Montfort University
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Transport in Thailand
Title: Transport in Thailand
Subject: Thailand, Automotive industry in Thailand, Judiciary of Thailand, Tourism in Thailand, Economy of Thailand
Collection: Transport in Thailand
Tuk-tuks are one mode of public transport in Bangkok and other cities in Thailand.
Transport in Thailand is varied and chaotic, with no one dominant means of transport. Bus transport dominates in long distances and Bangkok, with motorbikes dominating in rural areas for short trips, supplanting bicycles. Road transportation is the primary form of freight transport across the country. Slow rail travel has long been a rural long-distance transport mechanism, though plans are underway to expand services with high-speed rail lines extending to several major regions of Thailand.
Domestic air transport, which until recently had been dominated by a select few air carriers, has recently seen a surge in popularity due in large part to the expanding services of low cost carriers. In Bangkok, Pattaya, and other large cities, public motorbike taxis take people door to door. An overwhelming number of taxis can also be found in Bangkok. Since the country's first rapid rail transit line opened in 1999 in Bangkok, daily ridership on Bangkok's various transit lines has risen to over 800,000, with multiple additional lines either under construction or being proposed.
Private automobiles, whose rapid growth contributed to Bangkok's notorious traffic congestion over the past two decades, have risen in popularity, especially among tourists, expats, the upper class, and the growing middle class. A motorway network across Thailand has been gradually implemented, with motorways completed in Bangkok and most of central Thailand. Areas with navigable waterways often have boats or boat service, and many innovative means of transport exist such as tuk-tuk, vanpool, songthaew, and even elephants in rural areas.
Rail transport in Thailand 1
Metro systems 1.1
Rail links to adjacent countries 1.2
Road transport in Thailand 2
Thai highway network 2.1
Thai motorway network 2.2
Thai expressway network 2.3
Bus service 2.4
Alternative transport 2.5
Air transport 3
Airports 3.1
Airlines of Thailand 3.2
Waterways 4
River and canal transport 4.1
Ferries 4.1.1
Ports and harbors 5
Merchant marine 6
Rail transport in Thailand
Hua Lamphong Railway Station.
ASR (Class 158 Express Sprinter).
The State Railway of Thailand (SRT) operates 4,070 km of 1.000 m gauge railway line (372.63 km double track and 106.01 km triple track).
The SRT operates all of Thailand's national rail lines. Hua Lamphong or Krungthep Station is the main terminus of all routes and starts in Bangkok; Phahonyothin and ICD Ladkrabang are the main freight terminals.
The SRT has long been popularly perceived by the public as inefficient and resistant to change. Trains are usually late, and most of its equipment is old and poorly maintained. The worst financially performing state enterprise, the SRT consistently operates at a loss despite being endowed with large amounts of property and receiving large government budgets; it reported a preliminary loss of 7.58 billion baht in 2010.[1] Recurring government attempts at restructuring and/or privatization throughout the 2000s have always been strongly opposed by the union and have not made any progress.[2][3]
Metro systems
Bangkok is the only city in Thailand with a metro system:
Bangkok Metro or MRT
Bangkok Skytrain or BTS
Suvarnabhumi Airport Link
Pattaya Monorail (proposed)
Hat Yai Monorail (proposed)
Rail links to adjacent countries
Malaysia - same 1,000 mm (3 ft 3 3⁄8 in) gauge
Laos - 1,000 mm (3 ft 3 3⁄8 in) gauge across Mekong River on Thai-Lao Friendship Bridge
Cambodia - disused (being rebuilt)
Myanmar - defunct - (see Death Railway). But a projected extension will rebuild the route.[4]
Proposed link from Kanchanaburi to Port Dawei (2011)
Road transport in Thailand
Total: 180,053 km (2006)
Paved: 98%
Thai highway network
The Thai highway network links every part of Thailand. The four-lane highways often have overhead concrete pedestrian crossings interspersed about every 250 meters in populated areas. There are few on and off ramps on some eight-lane highways, most highways are separated by median with breakage for U-turns, except on major roads where ramp style U-turns predominate.
A number of undivided two-lane highways have been converted into divided four-lane highways and most highways are in good state of repair, greatly enhancing safety and speed. A Bangkok - Chon Buri motorway (Route 7) now links to the new airport and Eastern Seaboard.
Thai motorway network
An overview map of Bangkok's expressway system.
The Thai motorway network is small. Coupled with Bangkok's extensive expressway network, the motorways provide a relief from regular traffic in Bangkok. The Thai Government is planning infrastructure investment in various "megaprojects", including motorway expansion to approximately 4,500 kilometers.
Thai expressway network
Thailand uses the expressway term for the toll road or highway network. Most of expressways are elevated with some sections on the ground level. The current expressway network covers major parts of Bangkok and suburban areas. Expressways are used to avoid heavy traffic jams in Bangkok and reduce traffic time, but are sometimes congested in rush hour.
Buses are a major method of transportation for people, freight, and small parcels, and are the most popular means of long distance travel. Tour and VIP class long-distance buses tend to be luxurious, while city- and other-class buses are often very colorful with paint schemes and advertising.
There are fundamentally two types of long-distance buses in Thailand:
those run by The Transport Company, Ltd., (TCL), the state-owned bus company.[5] Known to Thais by the initials บขส (pronounced baw-kaw-saw), this 80-year-old company was formed by the government to ensure that citizens in even the most far-flung localities had access to the capital city, Bangkok. TCL buses are easily identified by the large golden coat of arms appliqued to each side of the bus.
those operated by private bus companies. These are too numerous to list and offer hundreds of routes in various service categories (express, VIP, local, air conditioned, etc.)
Local buses and Bangkok city buses come in various sizes, types, and prices, from half size, full size, double length, open window, fan, and air conditioned.
Includes tuk-tuk, taxi, van (minibus), motorbike taxi, songthaew, boats (in canals and rivers).
Main article: List of airports in Thailand and Busiest airports in Thailand
A Boeing 747-400 of the national carrier Thai Airways.
Suvarnabhumi Airport, Thailand.
Major international airports
Don Mueang International Airport (DMK) (Old Bangkok Int'l)
Suvarnabhumi Airport (BKK) (New Bangkok Int'l)
Chiang Mai International Airport (CNX)
Mae Fah Luang International Airport (CEI)
Hat Yai International Airport (HDY)
Phuket International Airport (HKT)
Krabi International Airport (KBV)
Samui International Airport (USM)
Surat Thani International Airport (URT)
Udon Thani International Airport (UTH)
U-Tapao International Airport (UTP)
With paved runways
Under 914 m: 5
With unpaved runways
Heliports
Total: 6 (2012)
Airlines of Thailand
Main article: List of airlines of Thailand
The national carrier of Thailand is Thai Airways International.
Damnoen Saduak Floating Market in Ratchaburi Province
Principal waterways: 3,999 km (2011)
3,701 km with navigable depths of 0.9 m or more throughout the year.
Numerous minor waterways navigable by shallow-draft native craft, such as long-tailed boats.
River and canal transport
In Bangkok, the Chao Phraya River is a major transportation artery, with ferries, water taxis (the Chao Phraya Express) and long-tailed boats. There are local, semi express, and express lines for commuters, though the river winds a lot, which can make the trip much farther than by bus. There is also the Khlong Saen Saeb boat service, which provides fast, inexpensive transport in central Bangkok.
Ferry service between hundreds of islands and the mainland is available, as well as across navigable rivers, such as Chao Phraya and Mae Khong (Mekong). There are a number of international ferries.
Laem Ngop
Laem Chabang near Si Racha
Phuket (Patong)
Total: 363 ships (1,000 GRT or over) totaling 1,834,809 GRT/2,949,558 tonnes deadweight (DWT)
Ships by type: bulk carrier 31, cargo ship 99, chemical tanker 28, container ship 18, liquified gas 36, passenger ship 1, passenger/cargo 10, petroleum tanker 114, refrigerated cargo ship 24, roll-on/roll-off 1, vehicle passenger 1 (2010)
Gas: 1,889 km
Liquid petroleum: 85 km
Refined products: 1,099 km (2010)
Bangkok Metro
Bangkok Skytrain
Songthaew
List of motor vehicle deaths in Thailand by year
2bangkok.com - Transportation developments and events.
Thailand Transportation Modes - Transportation modes.
Long distance travel and public transport info - Departure stations in Bangkok and timetables.
Online bus tickets, along with ferry, railways, and city transport timetables in Thailand
Thai national bus company
Railway map
Thailand Accident Research Center (TARC) - Road & Transportation Safety.
Driving in Thailand - Driving a car in Thailand and how to get a drivers license.
Transport photo in Thailand
This article incorporates public domain material from websites or documents of the CIA World Factbook.
Thailand articles
Peopling
Khun Borom
Tai peoples
Sukhothai era
Ayutthaya era
Thonburi era
Rattanakosin era
Siamese Revolution
Military period
Democratic period
Monarchy (list)
Baht (currency)
Thai people
solar calendar
Transport in Asia
Articles that mention track gauge 1000 mm
Articles to be expanded from February 2009
WorldHeritage articles incorporating text from the World Factbook
Bangkok, Malaysia, Myanmar, Cambodia, Thailand
Thailand, China, Manila, Beijing, South Korea
Rail transport in Malaysia
Kuala Lumpur, Kelana Jaya Line, Ampang Line, Kuala Lumpur International Airport, KTM Komuter
Automotive industry in Thailand
Thailand, Mazda, South Korea, Ford Motor Company, MG Motor
Judiciary of Thailand
Thailand, Government of Thailand, Politics of Thailand, Constitution of Thailand, Foreign relations of Thailand
Tourism in Thailand
Thailand, Chiang Mai, Pattaya, Phuket Province, Bangkok
Economy of Thailand
Thailand, Japan, Bangkok, United States, Economy of China
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Bass (vocal range)
Title: Bass (vocal range)
Subject: Iolanthe, Ruddigore, Music theory, Lance Bass, Boyz II Men, Singing, Itzhak Perlman, Power metal, Jukebox (Jamaaladeen Tacuma album), Boy
Female voices
A bass is a type of classical male singing voice and is the lowest vocal range of all voice types. According to The New Grove Dictionary of Opera, a bass is typically classified as having a vocal range extending from around the second E below middle C to the E above middle C (i.e., E2–E4).[1] Its tessitura, or comfortable range, is normally defined by the outermost lines of the bass clef.
1 Variations in bass range
2 Bass roles in opera
2.1 Basso cantante/lyric high bass/lyric bass-baritone
2.2 Hoher Bass/dramatic high bass/dramatic bass-baritone
2.3 Jugendlicher Bass
2.4 Basso buffo/bel canto/lyric buffo
2.5 Schwerer Spielbass/dramatic buffo
2.6 Lyric basso profondo
2.7 Dramatic basso profondo
2.8 Bass roles in Gilbert and Sullivan operettas
Variations in bass range
The low extreme for basses is generally C2 (two Cs below middle C). However, several extreme bass singers, referred to as basso profondos and oktavists, are able to reach much lower than this.
Within opera, the lowest note in the standard bass repertoire is D2, sung by the character Osmin in Mozart's Die Entführung aus dem Serail, but few roles fall below F2. Although Osmin's note is the lowest 'demanded' in the operatic repertoire, lower notes are heard, both written and unwritten: for example, it is traditional for basses to interpolate a low C in the duet "Ich gehe doch rathe ich dir" in the same opera; in Richard Strauss' Der Rosenkavalier, Baron Ochs has an optional C2. The high extreme: a few bass roles in the standard repertoire call for a high F♯ or G (F♯4 and G4, the one above middle C), but few roles go over F4. In the operatic bass repertoire, the highest notes are a G♯4 (The Barber in The Nose by Shostakovich) and, in the aria "Fra l'ombre e gl'orrori" in Handel's cantata Aci, Galatea e Polifemo, Polifemo reaches an A4.
Cultural influence and individual variation create a wide variation in range and quality of bass singers. Parts for basses have included notes as low as the B-flat two octaves and a tone below middle C (B♭1), for example in Gustav Mahler's Symphony No. 2 and the Rachmaninov Vespers, A below that in Frederik Magle's symphonic suite Cantabile, G below that (e.g. Measure 76 of Ne otverzhi mene by Pavel Chesnokov) or F below those in Kheruvimskaya pesn (Song of Cherubim) by Krzysztof Penderecki. Many basso profondos have trouble reaching those notes, and the use of them in works by Slavic composers has led to the colloquial term "Russian bass" for an exceptionally deep-ranged basso profondo who can easily sing these notes. Some traditional Russian religious music calls for A2 (110 Hz) drone singing, which is doubled by A1 (55 Hz) in the rare occasion that a choir includes exceptionally gifted singers who can produce this very low human voice pitch.
Many British composers such as Benjamin Britten have written parts for bass (such as the first movement of his choral work Rejoice in the Lamb) that center far higher than the bass tessitura as implied by the clef.[1] The Harvard Dictionary of Music defines the range as being from the E below low C to middle C (i.e. E2–C4).[2]
In choral music, voices are subdivided into first bass and second bass, no distinction being made between bass and baritone voices, in contrast to the three-fold (tenor–baritone–bass) categorization of solo voices. The exception is in arrangements for male choir (TTBB) and barbershop quartets (TLBB), which sometimes label the lowest two parts baritone and bass.
Bass roles in opera
This article possibly contains original research. Please improve it by verifying the claims made and adding inline citations. Statements consisting only of original research may be removed. (May 2008)
In classical music, and particularly in opera, the following distinctions are often made among different kinds of bass voices:
Basso cantante/lyric high bass/lyric bass-baritone
Main article: Bass-baritone
Basso cantante means "singing bass".[3] Basso cantante is a higher, more lyrical voice. It is produced using a more Italianate vocal production, and possesses a faster vibrato, than its closest Germanic/Anglo-Saxon equivalent, the bass-baritone.
Max, Le chalet by Adolphe Adam
Duke Bluebeard Bluebeard's Castle by Béla Bartók
Don Pizarro, Fidelio by Ludwig van Beethoven
Count Rodolfo, La sonnambula by Bellini
Blitch, Susannah by Carlisle Floyd
Méphistophélès, Faust by Charles Gounod
The King of Scotland, Ariodante by George Frideric Handel
Don Alfonso, Così fan tutte by Wolfgang Amadeus Mozart
Don Giovanni, Don Giovanni by Wolfgang Amadeus Mozart
Figaro, The Marriage of Figaro by Wolfgang Amadeus Mozart
The Voice of the Oracle, Idomeneo by Wolfgang Amadeus Mozart
Boris, Boris Godunov by Modest Mussorgsky
Silva, Ernani by Giuseppe Verdi
Philip II, Don Carlos by Giuseppe Verdi
Count Walter, Luisa Miller by Giuseppe Verdi
Ferrando, Il trovatore by Giuseppe Verdi
Daland, Der fliegende Holländer by Richard Wagner
Hoher Bass/dramatic high bass/dramatic bass-baritone
Hoher Bass or "high bass" or often a dramatic bass-baritone.
Igor, Prince Igor by Alexander Borodin
Boris, and Varlaam, Boris Godunov by Modest Mussorgsky
Klingsor, Parsifal by Richard Wagner
Wotan Der Ring des Nibelungen by Richard Wagner
Caspar, Der Freischütz by Carl Maria von Weber
Banquo, Macbeth by Giuseppe Verdi
Zaccaria, Nabucco by Giuseppe Verdi
Fiesco, Simon Boccanegra by Giuseppe Verdi
Jugendlicher Bass
Jugendlicher Bass (Juvenile Bass) denotes the role of a young man sung by a bass, regardless of the age of the singer.
Leporello, Masetto, Don Giovanni by Wolfgang Amadeus Mozart
Colline, La bohème (Giacomo Puccini)
Basso buffo/bel canto/lyric buffo
Buffo, literally "funny", basses are lyrical roles that demand from their practitioners a solid coloratura technique, a capacity for patter singing and ripe tonal qualities if they are to be brought off to maximum effect. They are usually the blustering antagonist of the hero/heroine or the comic-relief fool in bel canto operas.
Don Pasquale, Don Pasquale (Gaetano Donizetti)
Dottor Dulcamara, L'elisir d'amore by Gaetano Donizetti
Doctor Bartolo, The Barber of Seville by Gioachino Rossini
Don Magnifico, La Cenerentola by Gioachino Rossini
Leporello, Don Giovanni by Wolfgang Amadeus Mozart
The Doctor, Wozzeck by Alban Berg
Schwerer Spielbass/dramatic buffo
English equivalent: dramatic bass
Khan Konchak, Prince Igor by Alexander Borodin
Baculus, Der Wildschütz (Albert Lortzing)
Lyric basso profondo
Basso profondo (lyric low bass) is the lowest bass voice type. According to J. B. Steane in Voices, Singers & Critics, the basso profondo voice "derives from a method of tone-production that eliminates the more Italian quick vibrato. In its place is a kind of tonal solidity, a wall-like front, which may nevertheless prove susceptible to the other kind of vibrato, the slow beat or dreaded wobble."
Rocco, Fidelio by Ludwig van Beethoven
Osmin, Die Entführung aus dem Serail by Wolfgang Amadeus Mozart
Sarastro, Die Zauberflöte by Wolfgang Amadeus Mozart
Pimen, Boris Godunov by Modest Mussorgsky
Baron Ochs, Der Rosenkavalier by Richard Strauss
Baldassarre, La favorite by Gaetano Donizetti
Dramatic basso profondo
English equivalent: dramatic low bass. Dramatic basso profondo is a powerful basso profondo voice.
Il Commendatore, Don Giovanni by Wolfgang Amadeus Mozart
Hagen, Götterdämmerung by Richard Wagner
Heinrich, Lohengrin by Richard Wagner
Gurnemanz, Parsifal by Richard Wagner
Fafner, Das Rheingold and Siegfried by Richard Wagner
Marke, Tristan und Isolde by Richard Wagner
Hunding, Die Walküre by Richard Wagner
The Varangian (Viking) Guest, Sadko by Nikolai Rimsky-Korsakov
The Grand Inquisitor, Don Carlo by Giuseppe Verdi
Claggart, Billy Budd (opera) by Benjamin Britten
Bass roles in Gilbert and Sullivan operettas
The Mikado of Japan (The Mikado)
Sergeant of Police (The Pirates of Penzance)
Adam Goodheart (Ruddigore)
Private Willis (Iolanthe)
Carpenter's mate (H.M.S. Pinafore)
Don Alhambra (The Gondoliers)
The Notary (The Sorcerer)
Category of operatic basses
BBC Wales
Basses in Bach’s vocal works
Iolanthe
Gilbert and Sullivan, House of Lords, Henry Lytton, Lord Chancellor, Darrell Fancourt
Ruddigore
Gilbert and Sullivan, The Mikado, Doctor Who, The Times, The Pirates of Penzance
Western culture, Music, Indian classical music, Musical tuning, Consonance and dissonance
Justin Timberlake, Nsync, Nasa, Pop music, International Space Station
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Board of Guardians
Arrival & Accommodation
SibFU Honors College
Schools and Labs
Mega-grants
SibFU in UArctic
Journal of SibFU
Scientific Library
Scientific Environment
Extra-Curricular Life
Services on Campus
Gyms and Athletics
For Partnership
Manage your future
Version for visually impaired visitors
Russian Language Preparation Programs for International Students
Why SibFU
The Russian Language Preparation Programs are available at SibFU in The Pre-Admission Russian as a Foreign Language (RFL) Department for International Students. Russian language courses and general disciplines (pre-university courses) are Pre-University Programs for international students who would like to do their Bachelor's, Master's or PhD SibFU degree in Siberian Federal University or at other Russian universities.
Whether you want to study Russian for a few weeks, a year or two years, for academic or general purposes, we offer you a structured Programs of study. These Programs prepare international students for direct entry into Siberian Federal University.
At the end of your Preparatory Course, you will receive a Certificate Of Russian Language Proficiency. This certificate will ensure entry to SibFU degree Programs.
If you want to know more about our Russian Language Preparation Programs for international students, please check the course information below or contact SibFU by the e-mail admission [at] sfu-kras [dot] ru.
Courses of Russian as a Foreign Language
Academic hours
Cost, RUR
Russian as a foreign language one-year program (from 1 September to 31August) 880 140 000
Russian as a foreign language one-year program (from 1 September to 30 June) 720 100 000
Russian as a foreign language half-year program (from 1 February to 31 August) 580 90 000
Russian as a foreign language half-year program 360 50 000
Russian language summer course, 2 month (from 1 July to 31August) 160 35 500
Additional courses for the selected profile (special subjects)
Humanitarian Programs 144 13 000
Natural Science Programs 144 13 000
Economic Programs 144 13 000
Engineering and technology 144 13 000
Additional courses for foreign citizens who are studying at their 1st and 2nd years and who wish to be trained in majoring subjects for admission to SibFU or other Russian higher education institutions are avaliable.
SibFU offers a range of Russian Language Preparation Programs for international students seeking to upgrade their Russian language and study skills before starting a Bachelor, Master Degree or PhD programme.
Attractive and resonable prices
Communicative teaching techniques
Real Russian!
Individual attention for everyone
A relaxed teaching atmosphere!
Our courses combine a strong syllabus with a contemporary approach intended to build confidence and motivate students. Imaginative skills work and regular changes of focus are designed to capture students` interest. All our teaching takes place in a relaxed atmosphere because we understand that expressing oneself in a foreign language can be difficult. Laughter and humour help to make our students feel more comfortable about experimenting with the language and more willing to take risks!
Our course Programs focus on everyday spoken Russian and therefore all classroom activities are designed to reflect the language people use for everyday communication. The topics and materials used in our programes are chosen to reflect real life with all its ups and downs.
Russian Language Testing
In the Siberian regional centre for training and testing of foreign citizens — the local testing centre of the Pushkin State Russian Language Institute — there is an opportunity to take:
the Test of Russian as a Foreign Language (TORFL);
the Russian Language Test for Citizenship of the RF;
the Comprehensive examination in Russian as a foreign language, the history of Russia and fundamentals of the legislation of the Russian Federation (work permit in the RF/ patent; temporary residence permit in the RF; residence permit in the RF).
From January 1, 2015 a foreign citizen, applying for a temporary residence permit, a residence permit, a work permit or a patent is required to confirm the knowledge of the Russian language, the history of Russia and fundamentals of the legislation of the Russian Federation. For this, it is necessary to be tested.
The Siberian regional centre for training and testing of foreign citizens conducts a comprehensive exam and courses to prepare for the exam.
address: 660041, Krasnoyarsk, Svobodny Pr., 82A, room 3-40
telephone: +7 (391) 206-27-36, +7 913 576-22-34 (on weekdays from 8:30 a.m. till 05:00 p.m.)
e-mail: rusinyaz [at] sfu-kras [dot] ru
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Nasdaq Helsinki welcomes Rovio Entertainment
Nasdaq announced that trading in Rovio Entertainment ‘s shares commenced today on the prelist of Nasdaq Helsinki.
Nasdaq (Nasdaq: NDAQ) announced that trading in Rovio Entertainment ‘s shares (short name: ROVIO) commenced today on the prelist of Nasdaq Helsinki. Rovio Entertainment Corporation is a medium cap company within the Consumer Goods sector. The company’s shares are estimated to move to the main market of Nasdaq Helsinki on October 3, 2017. Rovio is the 79th company to be admitted to trading on Nasdaq’s Nordic markets* in 2017, and it represents the ninth listing on Nasdaq Helsinki in 2017.
"We feel extremely happy and honoured to have received so much interest towards Rovio’s IPO both by Finnish and international investors. Today's listing on Nasdaq Helsinki is an important milestone in developing Rovio into an even stronger games-first entertainment company", comments Kati Levoranta, CEO of Rovio.
“We congratulate Rovio on its listing today, and warmly welcome the company to Nasdaq Helsinki”, said Henrik Husman, President of Nasdaq Helsinki. “It is truly an honor for us to have a world-known gaming company to join our markets, and we look forward to supporting Rovio with the strong liquidity and international investor reach that a listing on our main market brings.”
Full press release:
http://business.nasdaq.com/mediacenter/pressreleases/1622962/nasdaq-hels...
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Pedestrian condemns reckless driver
Pedestrians walking along the Honiara City National Library walkway escaped a near fatal accident when a reckless driver drove his car onto the walkway last week.
RAGOMO KEEN TO JOIN KURUKURU
Inspiration captain calls on SIFF to contact Brazilian club for his release
____Stop Giving Cash____: Fuo____o tells Donors
The Managing Director of Tropical Glass and Aluminium (TGA). Justin Fuo____o has strongly urged the donor community to invest more in infrastructure and education instead of giving cash.
Sisilo presents credentials to US President
The Solomon Islands Ambassador to the United States of America His Excellency Robert Sisilo, presented his credentials to the United States President His Excellency Donald Trump on Friday 21 July 2017 at the White House, in Washington DC.
Demand for shipping in Malaita high
One ship per day is not enough for Malaita.
Police chief addresses business forum
Solomon Islands is a relatively peaceful nation after 14 years of the intervention by the Regional Assistance Mission to Solomon Islands (RAMSI).
Drunk driving remains high
Despite many warnings and messages against drinking and driving, the number of cases relating to drink and driving is still an issue.
READ SI WINS PRIME MINISTER’S HEART
A recently established literacy organisation in the Solomon Islands has won Prime Minister Manasseh Sogavare’s heart for its mission to battle the country’s high illiteracy rate by providing literacy classes and libraries in 600 villages across the country by April 2018.
SOSA raises funds, work starts
TWO weeks after raising more than $503,000 to support their old school, work has began on the Selwyn College students’ laundry and toilet facilities.
‘No injuries to dead body’
There were no external injuries or injuries that would cause death found on the body of the dead man found floating in the Mataniko River, Central Honiara.
Blue boat skippers’ sentencing today
The three captains of the blue boats who entered our waters and stole our marine resources will be sentenced this afternoon in the High Court.
USP students, staff celebrate Solomon Islands Independence
A celebration of the Solomon Islands 39th Independence Anniversary was held at The University of the South Pacific’s (USP) Laucala Campus on 7 July, 2017.
Baegeni leads golden boot race
CORPSE FOUND IN MATANIKO RIVER
Second semi final showdown
20 futsal training squad named
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Wudecoc Surname Ancestry Results
Our indexes 1000-1999 include entries for the spelling 'wudecoc'. In the period you have requested, we have the following 3 records (displaying 1 to 3):
wualter wuarderobe wuartermain wubbe wuburn wuburne wucherley wucht wucklot wucombe wud wudcok wudcot' wude wudebrok wudeburc wudeburc' wudeburch' wudeburg wudeclere wudecock wudecok wudecot wudecot' wudecota wudecote wudecroft wudecrofte wudedun wudefor wudeford wudeford' wudegat' wudegate wudeha' wudehall wudehalle wudeham wudehorseia wudehorshea
Grantees of royal lands and pardons (1175-1176)
The Great Rolls of the Pipe are the central record of the crown compiling returns of income and expenditure from the sheriffs and farmers of the various English counties or shires. This is the oldest series of public records, and the earliest surviving instances of many surnames are found in the Pipe Rolls. This is the roll for the 22nd year of the reign of king Henry II, that is, accounting for the year from Michaelmas 1175 to Michaelmas 1176. Most (but not all) of the entries in which names appear relate to payments for grants of land and fines or pardons. The large number of payments of fines for forest transgressions has been interpreted as a form of compounding for pardons by those who had rebelled during the recent years of unrest; or, looking at it in a different way, a form of extortion from the king in order to raise money to pay off the mercenaries with whose help he had quelled the rebellions. There is a separate return in each year for each shire, the name of the shire being here printed at the top of each page. Wales was still independent, in separate kingdoms, at this period, and is not included, except for 'Herefordshire in Wales'.
WUDECOC. Cost: £4.00.
Curia Regis Rolls (1219-1220)
The Curia Regis, king's court, of mediaeval England took cases from throughout the country, and its records are among the most important surviving from this early period. Rolls 71 and 71B for Michaelmas term of the 3rd and 4th years, and 72 and 73 for Hilary term and Easter term of the 4th year of the reign of king Henry III (Michaelmas 1219 to Easter 1220) were edited by C. T. Flower of the Public Record Office and published in 1938. Each entry is copied in full, the Latin extended from the abbreviated original, the personal and place names given as in the original; where these vary between duplicate rolls, variant spellings are given in the footnotes. The county of each case was marked in the margin in the originals, and this is shown in italics at the start of each entry in the printed edition.
Fine Rolls (1216-1246)
The fine rolls of the 1st to 30th years of the reign of king Henry III record part of the government administration in England. These excerpts from the rolls list in transcript applications by plaintiffs for various writs (such as 'ad terminum' and 'pone') and for assizes to be held by the justices in eyre to look into their grievances. A fine of half a mark (6s 8d) or a mark (13s 4d) was usually levied; the cases are normally identified by county, and record that the appropriate sheriff had been notified. There are also more extensive records, in which more detail is given. The excerpts were made by the Record Commission and printed in 1835.
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Real Deals
The True Net
Home OPINION PERSPECTIVE Study Reveals That Majority of Malays Unhappy with PH but Have Hope
Study Reveals That Majority of Malays Unhappy with PH but Have Hope
- Advertisement - [resads_adspot id="2"]
Five months after Pakatan Harapan (PH) took over Putrajaya, nearly 60% of Malays were dissatisfied with the new government’s performance, a joint survey by pollster Ilham Centre and think-tank Penang Institute showed.
Many Malays believe:
The government not serious about “Malay agenda”, including upholding Malay rights and Islam as official religion, fulfilling election manifesto, dealing with cost of living problems
Non-Muslims now in control of the government, with DAP calling the shots
But they also believe:
PH is not trying to end the monarchy
The ruling coalition would last more than just one term
It could carve a better future for the country
The government is doing a good job battling corruption, and is serious about eradicating graft and instituting a culture of integrity
They disagreed Dr Mahathir should serve out a five-year term as PM instead of handing over the reins to Anwar as originally planned
They agreed Anwar was the best person to replace Dr Mahathir as PM
The survey of 2,614 Malay respondents in the country, including Sabah and Sarawak, found that a high number did not believe that the government was serious about the “Malay agenda”, including upholding Malay rights and Islam as the official religion.
More than 60% of respondents believed non-Muslims were now in control of the government and that PH component DAP – a multiracial party with the second-most number of parliamentary seats in the coalition – was calling the shots in Putrajaya.
The findings dovetail with earlier studies which showed that PH faced a credibility crisis with Malays, having captured only 17% of their votes in the 14th general election.
However, despite their misgivings, more than half of those surveyed also believed that PH would last more than just one term and that it could carve a better future for the country.
“The Islamic narrative that PH promotes is difficult for Malays to digest as the philosophy is too deep,” said Ilham Centre research director Dr Mohd Yusri Ibrahim on PH’s pluralistic, progressive Islamic agenda.
“To win over the Malays, the government must portray itself as conservative and centrist, not progressive or right-wing conservative like PAS or Umno.”
The survey polled the opinions of a wide cross-section of Malays on a spectrum of issues, such as social mobility, religiosity, democracy and authoritarianism, Malay nationalism, religious conservatism, education, the economy and the government.
The survey was conducted via face-to-face questionnaire between October 24 and December 24.
When it came to their opinion of the government, respondents were generally dissatisfied at a whole range of issues.
Among the findings were:
59.5% of respondents disagreed they were satisfied with the performance of the government since GE14, versus 40.8% who agreed
54.4% agreed the PH government was ignoring Malay rights and Islam interests, while 45.1% disagreed
50.1% thought that PH was not serious about fulfilling its election manifesto as compared with 49.8% who said they were serious
58.3% believed that the federal government was not serious in dealing with cost of living problems
A majority of respondents also seemed to buy into the Umno-PAS narrative that PH was being controlled by the DAP and was espousing liberal values. These findings include:
62.9% who agreed that non-Muslims now controlled the federal government after May 9, versus 37.2% who disagreed;
62% believed that the DAP dominated the government’s decisions over other PH component parties while 38% did not;
58.9% thought that the federal government was being driven by a liberal agenda versus 41.1% who disagreed.
On the matter of the PH leadership, 53.6% disagreed with the idea that Dr Mahathir Mohamad should serve out a five-year term as prime minister instead of handing over the reins to PH de facto leader Anwar Ibrahim as originally planned.
Also, 51.9% agreed that Anwar, who had been Dr Mahathir’s successor-turned-nemesis-turned partner again, was the best person to replace the 93-year-old as prime minister.
Both have repeatedly pledged to abide by the promise, but no time frame has been set on the handover.
A bright spot for PH is that respondents gave the government the thumbs-up in the battle against corruption with 64.2% saying the government is serious about eradicating graft and instituting a culture of integrity.
Also, 53.2% disagreed with the notion that PH is trying to end the system of Malay rulers as compared with 46.8%.
Although they are critical of PH’s performance thus far, more respondents (54.4%) thought they saw a future for Malaysia under the coalition compared with those who did not (45.6%).
And despite what PH’s critics said, 52.3% versus 47.7% disagreed with the notion that the coalition will only last one term. – TMI
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Alton Towers Almanac
Park Guide
need2know
Please note that Alton Towers Almanac is no longer maintained or updated, and almost all information will be out of date.
For the latest information, please visit Alton Towers’ official website.
ATA › Need2Know › News Archive › News
2013: The season to Smile about
Monday, 18th March 2013 • By Jayne Sargeant
Alton Towers rolled up the shutters and allowed guests back for 2013 on Saturday 16th March.
It's shaping up to be an exciting season. Here's a round-up of what guests have to look forward to:
Work continues on the next attraction at the park, The Smiler. Previously codenamed Secret Weapon 7 and situated in X-Sector, the ride is scheduled to open in May, and will be another "world's first" for the resort. The Smiler has been manufactured by Gerstlauer who have been seen on site during the installation of the custom Eurofighter-style ride. We will be posting more information about The Smiler shortly, including the current rumours about how it will be a "world's first", and information on the new merchandise now available in resort shops.
The scare attraction The Sanctuary has returned for a short period. The doctors of The Sanctuary invite you to get corrected in the facility based inside The Towers. The entrance is through the conservatory, and entrance to the maze is free. ATA have already tested this out; it is not for the faint hearted and has definitely improved since its début in the 2012 Scarefest.
Burger King outlets have now all been replaced with The Burger Kitchen, a Merlin-owned chain of fast food shops. The Cloud Cuckoo Land restaurant has had a massive refurbishment to suit the new brand.
Oblivion has had a long awaited repaint and shuttles all have bright orange restraints again. Other areas of the park have been spruced up too, including parts of X-Sector, the Box Office on Towers Street and parts of Mutiny Bay.
Over at the Alton Towers Hotel there have also been some changes. 14 rooms have been refurbished with a galactic Moon Voyager theme, and there is also a new suite based on The Smiler.
On-the-day ticket prices are now £46.20 for adults and £37.80 for children under 12. Car parking has stayed at £6 per car. Further updates on current prices and offers will be coming to ATA shortly.
ATA — Latest News
» Featured
Special Events Diary
Retired Rides
» Trip Tip
If you are a family, book a family ticket and save some cash.
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Travel Forum ✈ Travel Forums ✈ Asia ✈ China ✈ Things To Do In Shanghai
Things To Do In Shanghai
(x1) | By: TravelMagma | 3,131 Views | 0 Replies
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Taking a look at Shanghai's ultra-advanced horizon, it’s not difficult to overlook how rich the city's past is. Get a taste of the customary Chinese culture at an enterprising bazaar brimming with extraordinary, teas, walk around the old hutongs or simply stuff yourself with the Oriental-style soup dumplings more commonly known as xiao long bao.
Shanghai has a mix of modern technology loaded with shops, eateries, temples, gardens, towers, and beautiful restaurants tucked neatly in one area. Some might be difficult to discover but are all worth the effort.
When To Go:
The best time to see Shanghai is during the Chinese New Year celebration when the streets get decorated with moving dragons throughout the road like fireflies with lit lanterns. Shang hai is usually full of festive and colorful activities during Chinese New Yer which happens within the first week of February. The Spring Season from March to May is also an ideal time to visit Shanghai because during these months when the flowers are in full bloom, the weather is good and makes the city more charming and attractive.
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Here are the top things to do when in the city of Shanghai.
The Bund (Wai Tan)
The Bund (Wai Tan) is a nice promenade overlooking the Pudong district which can be crossed by a ferry boat ride. It is the most historic and fascinating part of Shanghai. It also has a number of historic buildings designed in the European-style. You need to observe them in their majesty as it is very beautiful, both day and night, when the lights give the play of shadows making it even more striking. The Bund is the Shanghai anchored in the past and it's easy to cast a glance beyond the river to see the modern part of the city, where the neon lights of the skyscrapers of Pudong seem aliens landed on the grounds of Shanghai.
The sight of the skyscrapers that can be seen is amazing. At night, the spectacle of the illuminated skyscrapers is reminiscent of the film Blade Runner, and it is certainly more impressive than by day. At 22.00, the sound of the bell signifies that the lights must go down and the marvelous show ends. The most notable building is undoubtedly the modern TV Tower (490 m, the second tallest tower in Asia), oddly shaped, which houses a revolving restaurant on the top floor where you can enjoy a wonderful view.
In Shanghai, the skyline is filled with many skyscrapers that are all interesting, but the Shanghai World Financial Center is a special attraction. Apparently, the magic number is set to 100. Yes, it is the one hundredth floor that offers the highest observation deck in the building. In good weather, the visibility and the views are great. All the photos turn gorgeous. The equipment and services are commendable and really captures the qualities of a top tourist attraction of the capital city. When buying tickets, be sure to take to the top at the view from the same 97 floors. Tickets are not cheap though (150 Yuan, seniors over 60, students and children under 23 are on sale), but it's worth it.
You can walk toward the elevator, stop and look at the model of Shanghai at different times of the day and night with very colorful and visual picture. Then check out the brief information about Shanghai and armed with this knowledge, take a mini-trip into space on a super-high-speed elevator. View from 101 floors (450 meters) is wonderful and glorious. Downstairs you can see so many small houses, cars, and small people that you cannot almost recognize. Its high-speed lift in seconds and takes you to the unprecedented heights and in front of you is the great view of the city and the TV tower called the "Oriental Pearl". On bad weather conditions this attraction is kept closed.
Shanghai Circus World
Chinese circus bears no resemblance to other amusement groups as there are no animals, clowns and magicians used. But in the art of Chinese, acrobatics made impressive heights. Artists, age 12-23 years, amaze the audience with their extraordinary human dexterity skills and tricks. A lack of insurance makes you watch the entire show with bated breath.
That is why the Chinese circus is considered the most dangerous act in the world. At the Shanghai Circus World, one of the interesting highlights of the show is the acrobats segment about the antique vase, which weighs about 5 kgs and highly valued. The artists throw her, roll, twist, and throw this precious vase without letting it fall from their bare hands. Generally, follow all their movements without taking your eyes off them. Another act that is worth watching is the traditional performance of the girls with the rotating platter. The other breathtaking performance is the risky stunt of the motorcyclist in a bowl. It’s almost unbelievable, but in the end they turned out to be as much as 11 motorcycles in one bowl.
Scary looking but one really exciting show that will have your eyes focused on what they are performing onstage. Seeing everlasting fabric stories, artists appear on stage as members of one big play, houses, streets, forests unfold before your eyes is palpable and impalpable the same time. It is a fascinating spectacle that never fails to impress everyone, children, teenagers and adults.
Shanghai Museum (Shanghai Bowuguan)
If you do not know which museum to visit in Shanghai (since there are plenty of them), highly recommended and the most deserving of all is the Shanghai Bowuguan. It is located in the central Renmin Square without any admission fees. It is advisable to go from early morning to avoid queues and have time to assimilate the sight of all the treasures. Ming vases, furniture and furnishings of the Qing Dynasty, the traditional clothes of ethnic minorities, it is impossible not to be enchanted by the splendor of the millennial Chinese culture. After an overdose of skyscrapers and shopping malls, you will feel the need to see he little history of this great nation that you can find only here in Shanghai.
The museum concentrates on the history of Chinese civilization and the need to educate every guest how important their ancient culture and ethnicity is. The entire complex, as well as the unique architecture, deserves a thorough visit. They have collected here extraordinary treasures of Chinese art. From ancient bronzes to ceramics, jades from the manuscripts, from large sculptures of Buddhism to the thumbnail page valuable, calligraphy and national costumes. It is a combination of Chinese ancient civilization on four exhibition levels. For lovers of Chinese culture, this place is a must.
Riverside Promenade (Bingjiang Da Dao)
One of the main things to do in Shanghai is precisely this beautiful Riverside Promenade (Bingjiang Da Dao) which runs through the city. The best time to visit is in the evening to see a landscape that is more characterized with illuminated skyscrapers. The walk along the river with scenic views, such as the television tower and local prestige gives an impression that the city is still growing, not to mention the typical "Pagodas" that stood firm on authentic water gardens. The most beautiful part of the walk is to the North, where you can admire in a row the colossal statue of Mao Tse-Tung, a wonderful memorial that emerges from a forest of flowering plants.
The shrine is also dedicated to the heroes of the people surrounded by vast carpets of flowers, and finally the huge terrace overlooking the confluence of Suzhou Creek with the Huangpu River, with the view of the marina and with the best possible view of Pudong. If there is a place that deserves the name of the viewpoint, this is it. Indeed, on this terrace it is easy to find film crews busy preparing reportage on fashion, newlyweds who are doing the photo shoot remember the background of skyscrapers and hordes of visitors who click frantically with their cell phone and their digital camera.
Shanghai Hongqiao Railway Station
Hongqiao is both a railway station and airport. Both these buildings are a single entity. From the Shanghai Hongqiao Railway Station you can go by train or fly to any destination in China. High-speed trains arrive directly to the closed top of the station building. Everything here is very modern and comfortable. You will be impressed by its size and its clean and well maintained surroundings. The new train speed runs up to350 kilometers per hour. Generally, since Shanghai is hugely populated, it is advisable to always do everything with a margin as big enough space for your gear and a lot of queues. This transport system is very informative and everything is done to ensure that people quickly get on the train and leave the station.
It is located on the edge of town with a couple of subway stops at the zoo. If you have not bought a ticket in advance, then it is necessary to arrive at least half an hour before departure. Selling is done in only one place in the order of 10 banks, but it is not so fast. After that, (or better yet queue) search your way to the waiting room, where further examination of baggage and body frisking occurs and be guided by your way - right-to-left in a huge hall towards the overhanging platforms. The gates usually open in 10 minutes before the train leaves, so do not relax too much. In the waiting room, you can eat buffets or shop in the stores.
Old French Concession
The Old French Concession is a city within a city and the only European area in Shanghai, China. The restaurants and cafes completely Europeanized with lots of cosmopolitan crowd in the street that makes you feel you are not in China. It is one of the old places dating back its inception from the 19th – 20th century and showing one of the best foreign communities of Shanghai. The whole place is designated for merchants from France. It is a fun place to walk, hike, explore the houses and appreciate the old architecture.
Here you can find anything, as there is a wide variety of bars, cafes, restaurants, vintage shops and houses with a long history. Prepare for a walk through the old town, carefully read the brochure and learn the routes, so you will not miss something interesting to see what you have planned to see on this trip. The calm atmosphere is all cozy like home and very different form the row of the modern buildings and maple trees on the road. In the evening, the small alleys of the old houses of the French legation premises are filled with lights and people who attend them. These small houses two / three-storey high-rise buildings gets surrounded by a thousand lights that seem a haven of peace away from the hustle of modernity.
Garden of Contentment (Yugarden)
The Garden of Contentment is located in the Old City of Nanshi that includes two or three dozen halls and pavilions many of which are on the water. By area, the garden is not very big, but you can wander around and an hour or two and discover more interesting features (rocky cliffs, flowers, plants, old trees, paved pathways and family areas). You will see lots of greenery, and compelling architectural solutions. Despite the huge crowd turnout on weekends, the place remains a quiet and peaceful place. Delight in the spectacle of nature where you can rest your eye on such beauty. All the more surprising is the walk in the garden, knowing that beyond it stands the concrete jungle and skyscrapers. The garden is stunningly beautiful.
Oriental Pearl Tower (Dongfang Mingzhu)
One of the top things to do in Shanghai is to climb all the way up to the Oriental Pearl Tower (Dongfang Mingzhu). The upper levels deliver high-speed lift, which shows how high you are.
It can rise to different levels (ticket price depends on the level - the lower, upper and cabin space). There is a revolving restaurant on top of the field. The ideal time to visit is late in the afternoon, when it starts to get dark, to have a chance to look at the city even in daylight and as the sun sets making the visit to this imposing tower an unforgettable experience.
Tian Zi Fang
The Tian Zi Fang is a nice place to spend an evening to enjoy an interesting walk and fine dining. In addition to numerous shops there are many exquisite Chinese restaurants and cafes that can be found with good ambience and acceptable prices. But the most valuable thing here - it's the atmosphere; very nice walkways and despite the large number of people, it does not appear like a tourist spot.
Separately recommended is a shop with souvenirs of leather (notebooks, belts and purses) - qualitatively and for every taste, that you can buy as gift for friends back home. In winter, the shops here prepare fragrant mulled wine, and in summer entertaining magicians can be found in every corner. It is not very cheap, but it is the best place for those seeking souvenirs and crafts from Shanghai.
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On July 7, 2019 Steve Randall taught a seminar on the 'zone' of peak performance, contrasting the first and third levels of TSK, and including third-level quotes on twelve dimensions that may be helpful in embodying the third level.
What is the zone? Why do athletes have trouble describing the zone? Why isn’t the best way of doing things just common knowledge? Can we describe the zone in terms of personality styles or attitudes? Virtues, or spiritual qualities?
Video for the seminar is on YouTube at: https://youtu.be/K1gjAPg613k
Script for the seminar
Exploring the Zone Ppt script
1. Discuss what a vision of peak performance might be like, and what it could offer us
2. Inquire about and identify essential qualities of our peak experiences
3. Compare to our typical way of being in the world and identify important ‘normally’ limiting presumptions, perceptions, and habits
How are the ‘Zone’ & ‘Peak experience’ related?
What do you think the word ‘zone’ means? What about the term ‘peak experience’? Are they interchangeable?
American Heritage: (informal idiom) says the zone is “a state of focused attention or energy so that one's performance is enhanced.” [Merriam-Webster online dictionary: the ‘zone’ is “a temporary state of heightened concentration experienced by a performing athlete that enables peak performance.”]
Murphy and White say the zone is a state of mind "in which one’s performance seems supernormal." (Murphy and White, In the Zone, 1995, ITZ, p. 3)
The definition of peak experience comes from dictionary.com: “a high point in the life of a self-actualizer, during which the person feels ecstatic and more alive and whole than is usual.” [From Wikipedia: “Peak experience is a term used to describe certain transpersonal and ecstatic states, particularly ones tinged with themes of unification, harmonization and interconnectedness.”]
I usually use the term ‘zone’ and ‘peak experience’ interchangeably, although the term ‘zone’ usually describes a performance of some kind, often athletic. Peak experience can refer to a particular state of being, with no performance implied. [I certainly don’t consider the zone a kind of special ‘place’ in the mind that we can ‘go to’ somehow to make everything right, or perform at our best.]
Experiential aspects of peak experience constitute what I call the zone. People have empirically determined varied aspects of peak experience. These can be portrayed on a single diagram. But not every peak has the same identified qualities.
Why study the zone?
What if I want to travel to a particular part of San Francisco, say Embarcadero Center. How do I get there? What do I need to know?
It’s helpful to know what the Center looks like. Perhaps I was there before, and I remember what it was like. Perhaps I can ask others what it’s like. It can also be helpful to know how it’s different from similar places.
Suppose I meet someone from out of town, and I ask them which way to go. They might be able to tell me what the Center is like, and how it differs from other places, but they may still not be able to tell me how to get there from where I am. They may not know the directions, highways, neighborhoods (good and bad), construction zones, one-way streets, etc.
There may be many ways to get there, but it’s useful to know both where you’re going, and where you are now, how the two are relatively positioned on a map, and also some information about the surrounding terrain and neighborhoods.
Finally, there may be many different vehicles I can use to get there.
Is there a balanced, general description of the ‘zone’, or peak experience?
If it’s general--applicable for any person, environment, and task--it cannot be defined in terms of specific things, processes, or styles. This would confirm the idea that “The best things in life aren’t things.”
[Defining such a vision is subtle, perhaps “the subtlest aspect of the learning organization—the new way individuals perceive themselves and their world.” (p. 12, FD)]
If a vision didn’t tell us specifically what to do, perhaps it would tell us how best to do, or be. (In other words, it deals with how experience is structured, and not just with the content of experience.) Perhaps perspectives, frames of mind, world-views, & qualities of experience can define the zone. These qualities are in fact what stand out in statements about peak experiences by geniuses, mystics, and peak performers of all kinds. Take race car driving, e.g. Drivers in peak experience don’t talk about how to negotiate turns, deal with their fear, or other specifics like this; they talk about being one with the car, e.g.
Finally, when applied to work situations, it should help balance productivity, quality, and well-being, rather than emphasize productivity or the bottom line’ as many organizations like to do. It’s pretty obvious that when people focus primarily on getting things done, it’s easy to burn out rather than having anything like a peak experience.
Let’s explore all our past peak experiences a bit and see what we can learn from them. What were some peak experiences you had? Think of many different kinds. [Give examples: skiing, being in love, insight, lying on the beach.] We’ll take five minutes to recall these and make some notes about them.
Note the essential qualities of peak experiences you recall. Not just the specific events, what you were doing, but what made the experiences very special, what made them your ‘best’ experiences. Now tell me what made them special, and I’ll record our results on the easel.
[Let’s see if we can draw any conclusions. Do some of our experiences have some of the same qualities? Do all peak experiences have same qualities? Do peaks have same proportions of qualities?]
Twelve Dimensions of the Zone can be explored
(Simple Circle Diagram)
This slide transitioned to the embedded Ppt file below.
Twelve dimensions slides script
Slides 1 and 2
What happened to personal will, effort, and control?
‘Normally’ things take effort, discipline, will power, control; we have stress and struggle against some kind of friction and chaos that seems built into the world.
With high involvement, things are spontaneous, effortless, seem to go by themselves in a frictionless flow. Action is powerful; things seem coordinated, synchronous, serendipitous.
“We live in a very fantastic, magical world. There is no 'doer' or performer of the magic.” (p. 107, TSK)
Are you applying effort or control to something that feels separate from you, or does your activity seem to flow effortlessly “by itself?”
Creatifvity
What was the source or cause of things? How did experience seem to arise?
‘Normally’ there’s a strong sense of sameness and continuity from moment to moment. Things are readily explained in terms of causes and important past generative events. People are quite habitual, have a very fixed identity, and exist in a very stable reality.
With high involvement, everything and everyone seems to be mysteriously created anew each moment.
“With our position not established in advance and our identity indeterminate, a new choice opens: We can be what we are manifesting.” (p. 148, DTS)
Do things feel familiar, somewhat predictable, or even habitual, or does each new moment, along with all that appears in the momentary scenario, seem spontaneous and fresh?
How did the experience of accomplishing things change?
‘Normally’ energy feels divided. We feel limited in what we can produce, strive against resistance, and seek satisfaction and completion at some later time.
With high involvement, self merges with process, and fulfillment is naturally present, not projected into a future time. Coherence of energy effortlessly produces optimal results.
Are you looking forward to being done with the work, or are you currently fulfilled within your work-in-progress?
Slides 10 and 11
Objective space
How did the experience of space, boundaries, objects, and the world change?
‘Normally’ space is like a container for objects, people, and events. Space is contrasted with things, extends in all directions, seems divisible, and separates things. Its volume is limited.
With high involvement, space is not extended or divisible, doesn’t separate things, and is not limited in its accommodation. Things are space.
“Space projects Space into Space. There are no fixed points and no fixed identity, but quality and character remain.” (p. 242, KTS)
Do objects and events take up space and appear to be separate and dispersed, or are do they seem intimately connected in and even as one space?
How did mind change?
‘Normally’ there’s a strong sense of separation between our mind and the outside world and others. There’s a stable sense of our self controlling or using our mind.
With high involvement, subject and object don’t feel divided, nor do people’s minds. There’s no sense of a locatable center from which one operates. There’s a merging with what is ‘other’ in an interpenetrating space.
“We are opening to the emergence of a 'knowing' which discerns that thoughts are 'going nowhere', 'getting nowhere', pointing nothing out.” (p. 57, TSK)
Is there a private space or personal world that feels separate from everything outside, or do inner and outer, subjective and objective appear to be inseparable facets of the same undivided space?
How did the feeling of identity change?
‘Normally’ there’s a strong and continuous sense of self at the center of experience.
With high involvement, the separate self disappears. There’s no ‘owner’ or director of experience, and little felt separation from others, events, and objects. Rather than separate existence, there’s identity with the ‘other’.
“A new experiencer is called for—not the self, not mind or consciousness or any other agent of the self—an experiencer attuned directly to the energy of the present. A way presents itself: The experiencer can be transformed directly into light.” (p. 168, DTS)
Is there a sense of self that stands apart from experience and externals, or do you feel identified with, or absorbed in, what is happening?
Locus of Knowing
Where did knowing happen?
‘Normally’ perception and knowing are directed by a central self and interpreted by mind. Understanding is largely intellectual and felt to arise in the located mind or brain.
With high involvement, awareness is ‘with’ the content or object known. Understanding is not localized. Knowing doesn’t involve an act caused by a central self or mind.
Full knowledge dissolves the 'distance' between knower and known that characterizes conventional not-knowing. With no distance, an intimacy of knowing emerges, and knowledge becomes inseparable from love. (Tulku, 1987, p. xlviii)
Is knowledge simply something that you or others possess or lack, or is there a sense of being intimately part of what’s around you, knowing things that are happening ‘from inside’ them?
Content of Knowing
What happened to the content of knowing?
‘Normally’ knowing is largely limited to identification, judgment, thinking, categorizing, and sensing. Knowledge is directed, collected, and possessed by a self.
With high involvement, there’s no subject-object duality. Awareness merges with content, event, or object known. Knowing is an illuminating clarity merged with object known. Knowing is spontaneous and unowned.
“Refining this quality of clarity in everything, it becomes possible to use this clarity itself rather than ‘mind’ and ‘things’ as our orienting guide.” (pp. 281-2, TSK)
Is knowledge only identification, categorization, judgment, and detached observation, or also an illuminating clarity merged with the subject being explored?
What happened to our typical fragmentation of being? How were health and wholeness?
‘Normally’ mind, body, self, and personality feel fragmented. Reason, emotion, sensation, and intuition aren’t integrated.
With high involvement, all aspects of being feel harmonious, integrated or whole, complete, and nourishing.
“An integrated, natural intelligence, unfragmented into reason, emotions, sensations, and intuition, is our greatest treasure, and our key to progress.” (p. xxxiv, TSK)
Are there divisions among your self, mind, body, and personality, or is there a natural sense of wholeness, fulfillment, and satisfaction?
Need and Fulfillment
What happened to desire, need, and fulfillment?
‘Normally’ the self seems to need certain things and feelings and to avoid others. There’s a basic sense of lack or deficiency that the self tries to fill or satisfy.
With high involvement, all experience is appreciated and immediately fulfilling; there’s no dependence upon any means for satisfaction.
“We participate in an uncontrived intimacy. We are also absolutely self-sufficient in a nonegoistic sense. We can draw nourishment and energy directly from our own being, directly from Space and Time.” (p. 287, TSK)
Are you driven by a need or a desire for pleasure, or is everything being found to be immediately and inherently fulfilling?
Feeling of time
How did the experience of time change?
‘Normally’ time feels like an uncontrollable and continuous linear flow from moment to moment. Past, present, and future feel separate, and we’re positioned in ‘the present’.
With high involvement, there’s no feeling of time flowing, just timeless and positionless involvement in whatever’s happening. Past, present, and future don’t feel separate.
“There is no duration remaining in which acts of perception might occur and no fixed place for a 'watcher' to stand: thus, there is no 'experience'.” (p. 52, DOT I)
Do you notice a feeling of time flowing in the background, or are you timelessly involved?
Feeling of reality
How did reality seem to change?
‘Normally’ things are contrasted with space, and seem to have a particular inherent core of substantiality.
With high involvement, things have an openness rather than some apparently characteristic density or substance. Everything seems ephemeral, a whole without separations or parts.
“All existence and experience is like an apparition, a surface with no substantial core, no dimensions to it, no wider and founding environment.” (p. 199, TSK)
Does reality seem solid, fixed, and substantial, or does everything seem somewhat fluid or dreamlike?
Script (continued)
At this point we returned to the Exploring the Zone Ppt
Slide 8 Diagram
Here is the zone circle, which summarizes research I’ve done on the ‘zone’ of peak performance, and how it compares with our ordinary experience. This, with descriptions and quotes for these dimensions, appears in my book, Results in No Time. Twelve dimensions of enlightened experience, which can collectively be called the zone, are at the center. Our ‘normal’ experience is depicted on the periphery. These twelve dimensions can be used to measure our increasing or decreasing involvement as we work.
Central values of the circle describe how, best ways, to experience, which are independent of what we do. At the center are deeply shared values, and our most valued qualities. As we become masters in life, our experience changes from having qualities on the periphery to having those at the center of circle.
Continuous improvement can be defined as increasing involvement, moving from experience at the periphery toward experience at the center whenever possible. By fostering this type of continuous improvement, we have an effective implementation of “Managing by values,” whereby the values are the boss, our principal guideline. We have a means for “Continuous improvement through a commitment to act on our expressed values.” MBV, p. 68
What's a General Description of the Zone?
Considering only the time, identity/knowing, and space dimensions, we might say that zone experiences can be characterized by flow, glow, and zero: qualties of unobstructed flow (time dimension), luminous presence and positionless knowing (identity/knowing dimension), and complete and dimensionless openness (space dimension), with varying proportions of these qualities in different experiences.
Thus using the term "flow experience" to characterize all peak experience, as Csikszentmihalyi does in the book Flow, can be misleading.
What's not in the zone?
We might note that such experiences are not characterized in the least by the presence or absence of particular ordinary objects, processes, or events. The anecdotes do not focus on conventionally designated things or events--which are what we usually focus on in 'normal' experience. Indeed, this fact is congruent with the saying that "the best things in life aren’t things." No wonder the zone is so difficult to recognize, or even to adequately describe!
What's not in the zone? (2)
But much more significantly, we find that all the zone experiences lack one or more of the common strictures, the typically stable, fundamental, and restrictive (at least compared to the zone qualities) experiential structures such as subject-object, substance, here-there, distance, and before-after. This freedom from 'normally presumed and persistent' restrictions is likely what makes zone experiences "so valuable that they make life worth while by their occasional occurrence." (TPB, p. 80)
Although in themselves the anecdotes we examined do not imply the following conclusion, we might easily speculate that the ultimate zone experiences--perhaps of those who might be called self-actualized or enlightened--would be devoid of all strictures.
Although the zone seems to be a natural state of mind, all 'normal' and neurotic personal as well as culturally 'normal' complexes, habits, and strictures seem to limit the appearance of the zone, somewhat the same way that clouds limit our view of everpresent sunlight. Maslow's subjects said that their peak experiences were "reported as illuminations, as true and veridical characteristics of reality which previous blindness has hidden from them." (p. 102, FRHN) Yet many structures in our experience--for example, 'positive' habits and strictures like self-other, linear time, before-after, and substance-- are taken for granted, seen as features of normal knowing and perception, rather than being seen as limitations to well-being or performance. But apparently the more we break up and dissolve these obstructions, the more intensely and frequently the zone shows up. If this is so, whatever we can do to decrease the holding strength of habits and strictures will probably contribute to our improving performance, fulfillment, and awareness. This aligns with statements by Tarthang Tulku: "We may have had glimpses of a higher destiny, but to shape our lives in accord with that vision, we must learn quite specifically how to activate an inquiry that can cut through the structures of our present knowing." (p. 71, VOK) And: “Full implications of the . . . vision will reveal themselves most clearly through a focus on experience that calls the framework of experience into question.” (p. xxviii, LOK)
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Marlena Khramov (Ukulena) is a Singer-Songwriter & Multi-Instrumentalist, born in the L.A. County City of Santa Monica, raised in the O.C. City of La Palma, & grew up listening to the best kind of music, thanks to her parents, Igor Khramov (Professional Singer/Trombonist/Compser etc. in Band's Limpopo & Red Elvises early 90's) & Janelle Frese (Professional Women's Baseball Pitcher/Author/Drummer, first drummer & manager of Limpopo & Red Elvises early 90's). Her parents gave her the best of both cultural worlds. Igor was born & raised in a small villiage called Yegorevsk, Russia. Janelle, a California native... Growing up, Marlena was in & out of sports, dance, & music/piano lessons. Though, she always new the stage was hers when she belted out her soulful voice. She'd been singing her whole life, recording with her father since age 6, being in elementary school church choir, musical theatre during junior high, & high school show choir. Always creating songs & being surrounded by wonderful music! Come 2013, Marlena & her also musical sister Mikayla, lose their beloved Father, Igor at age 50. The most talented man in their eyes & changing their whole aspect & passion on music. Music had never been more alive for Marlena, almost like her father was in her composing. Well, getting all of their father's instruments after his passing, Marlena picked up his fragile Ukulele & fell in love. Later being gifted a beautiful Concert Fender Ukulele from an old friend, she got better & better and created her show, "Ukulena"! XOXO
Ukulena
(Oo-Koo-Lay-Nah)
A "play on words" of the singer/musician Marlena and her Ukulele.
Ukulena & Her Smitten Kittens
Vocals/Ukulele-
Marlena Khramov
Lead Guitar-
Logan Dumont
Drummer- Blake Rehling
In 2012, Marlena and her big sis' Mikayla formed their first band, The Rad Cats. They opened Ronnie Mack's Barn Dance 1st live webcast - A Carl Perkins Tribute - where they were introduced & known as "Orange County's Collins Kids".
In 2013, heartbroken by their Father's tragic passing, changed their band name to The Nesting Dolls, an homage to their Russian heritage. When the sisters part, they each form their own creative venture. Mikayla is "Theone" (Blues, Rock, Country, Americana). And Marlena is "Ukulena" (Tiki, Soul, Rock 'n Roll).
Ukulena can play Solo Performance, Duo, Trio, or Full Band! Old Tunes to New Tunes, & a pineapple load of ORIGINALS!
Contact and Booking: ukulena@yahoo.com
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Type: Posts; User: Northman; Keyword(s):
Thread: Some cool 1.5 exclusive screenshots (**Welcome to the Battle Coliseum!!**)
by Northman
Poll: Well, true. It's not over yet. The crew that put...
Well, true. It's not over yet. The crew that put Half-Life: Black Mesa together took 8 years just to produce the 1st half. So there's yet hope left for this project.
But you have to understand...
Poll: I wonder if Gemini got C&D'd? The release of...
I wonder if Gemini got C&D'd? The release of Capcom's official RE2make happened at an inconvenient time regarding this project. There's the possibility that they didn't want competition from...
Poll: Greetings, good sir. Would it be possible to get...
Greetings, good sir. Would it be possible to get some proof of life again? Possibly another trailer for Halloween time, to whet the appetites again?
Thread: RE0 N64 – forever a mystery?
This is Capcom we're talking about. The dev and...
This is Capcom we're talking about. The dev and the rights holder. Surely they still have access to a build and a dev unit to play it with, so they can capture fresh footage. Not out of the question...
Poll: All of this is so exiting. This one, single video...
All of this is so exiting. This one, single video game proto has an absolutely fantastic story attached to it, bigger than I ever thought. The scale of it all is just so absurd, no other game gets...
Poll: Is IGAS even working on this thing anymore, or...
Is IGAS even working on this thing anymore, or did everything fall squarely on Gemini, after they announced the switch to his engine? Mr. BZork has been disturbingly silent ever since then. My fear...
Thread: It's here - RE2 Remake Official E3 Trailer
I'm absolutely elated to see that they added so...
I'm absolutely elated to see that they added so much stuff from the Biohazard 1.5 proto into the mix. The firing range is almost 1:1 recreation of the 1997 original. The new jail area definitely...
Poll: Supposedly it was Leon's reaction to Elza...
Supposedly it was Leon's reaction to Elza crashing trough the front doors with her bike, and drawing all the zombies' attention to their direction. A.k.a Elza did a very BAAAD thing. This is one of...
Poll: How do you guys feel about the Playstation...
How do you guys feel about the Playstation Classic? It was broken very quickly and it's already possible to load custom ISOs with it. In the future, maybe even homebrew programs, like improved...
Awww, Claire doesn't get the blonde hair when she...
Awww, Claire doesn't get the blonde hair when she wears the Elza-costume. :( I was hoping for a full change of appearance, hair and facial features included.
Nice touch with the Walking...
Is it just me, or is that Birkin-fight VERY MUCH...
Is it just me, or is that Birkin-fight VERY MUCH like the elevator scene from Bio 1.5 proto? Down to William screaming "Sherry!" during the battle? And there's a similarly designed, closed space as a...
Poll: But who are they gonna send it to? To this day...
But who are they gonna send it to? To this day nobody knows the identities of the constituent members of team IGAS. They did well to keep this as secret as possible. Now they can't be painted as...
Damn... It actually looks promising, like...
Damn... It actually looks promising, like something I'd truly wanna play. But I don't own a PS4, and I'm not sure if I even wanna get one. Between this, and the new DMC5 they also announced, maybe...
Poll: I'm really hoping we'd see something getting...
I'm really hoping we'd see something getting released this year.
Poll: Thanks again for showing proof of life. (Holy...
Thanks again for showing proof of life.
(Holy shit, was that functional enemy AI?)
Poll: That's what I'm hoping. Not just the suit, but an...
That's what I'm hoping. Not just the suit, but an actual complete skin and character model to transform Claire fully into Elza.
Poll: Oh, that's a nice nod to old fans. The 1st time...
Oh, that's a nice nod to old fans. The 1st time in over 20 years, when they actually acknowledge that the prototype once existed.
Also, mentions that the RPD will be re-designed. Maybe we'll see...
Poll: The fans still wouldn't be able to use those...
The fans still wouldn't be able to use those brandings legally. Their commercial use by non-CAPCOM entities would be a breach of copyright. The fans would have to come up with something of their own.
Thread: Gaiden's musical influence
If you're gonna copy somebody, at least copy the...
If you're gonna copy somebody, at least copy the best.
Poll: ZOMG! New stuffs! o_o Wow, they actually added...
ZOMG! New stuffs! o_o
Wow, they actually added that gimmick from the Re-ReMake, where the camera follows the player. :P
The staircases connecting the floors are looking really nice in action....
Poll: Exactly. They paid 5 figures just to obtain the...
Exactly. They paid 5 figures just to obtain the game disc. You don't just quit after something like that.
Thread: George Romero has passed away at age 77
In his honor, I think we should watch them again....
In his honor, I think we should watch them again. Great work, really. They capture the essence of the game really well.
https://www.youtube.com/watch?v=5vSlRrL689Y
And the other one:...
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The Cryptocurrency Network
$1.7Bn Raised, Becomes First Ever Billion Dollar ICO
October 21, 2018 admin 17Bn, Billion, Dollar, ICO, Raised
With 1.7 Bn$ Raised, TON Becomes the First Ever Billion-Dollar ICO in the History of Cryptocurrency.
The brothers Pavel and Nikolai Durov continue to demonstrate to the world their ability to do business, reaping a successful career in each of the investments they make. Pavel Durov has known how to interpret the needs of the markets, and his first commercial success came with the creation of Vkontakte, a company that knew how to take the benefits of Facebook, adapting it to the customs and needs of the Russian population, while adding a series of services that Facebook users cannot enjoy. What began as a small project ended up becoming Europe’s leading social network, providing Durov with a profit of approximately half a billion dollars after a sale motivated probably because of political problems.
In his “farewell” he said he would focus on a new project: “Telegram” an instant messaging application, which would soon become Whatsapp’s main competitor. Its features surpassed those of the web messaging giant: Encryption, speed, and automation. On this platform, a series of new developments were built that boosted parallel economies. Bots are an example: In an interview with TechCrunch, Pavel Durov mentioned that a company developing bots for Telegram was sold for eight figures.
Now Pavel Durov is back in the spotlight with a goal to revolutionize the world of blockchain with “Telegram Open Network”, a DLT that wants to solve the traditional problems of cryptocurrencies with many promising approaches.
In order to meet its objectives, TON announced a private presale before the ICO. They wanted to raise at least 1.2 Billion Dollars, making TON the most ambitious project in terms of fundraising for an ICO. In the first sale, on January 29, they declared to the SEC the collection of $850 million by 81 investors, which gives an average of just over $10 million per investor. An impressive figure compared to what a typical investor would spend on a regular ICO.
However, despite the significant amount raised, they announced a second private round of sales. This round, according to a FORM-D released by the SEC, raised an additional $850 million from a group of 94 investors who deposited a mandatory minimum amount of $1 million. The sale took place on March 14 and reported to TON Issuer Inc. a total of 1.7 Billion Dollars.
Will this be enough to guarantee the fulfillment of its roadmap, which proposes the last quarter of 2018 as the date of network implementation?
>>MEvU ICO – The Social Betting Platform On The Blockchain
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Emaar Community Token | Owners of Burj Khalifa Plan ICO
March 11, 2019 adminBurj, Community, Emaar, ICO, Khalifa, Owners, Plan, Token
At nearly 3,000 ft tall, the Burj Khalifa is the tallest building in the world. Soon,...
ICO Scams | FBI Attempts to Educate Investors on ICO Red Flags
February 19, 2019 adminAttempts, Educate, FBI, Flags, ICO, Investors, Red, Scams
The United State Federal Bureau of Investigation (FBI) has taken it upon itself to educate investors...
Colorado ICOs | Regulators Stop Another 18 ICOs
November 22, 2018 adminColorado, ICOs, Regulators, Stop
The US federal authorities are strict against ICOs, or initial coin offerings. Projects are being shut...
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LATEST-BUSINESS
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Home EDUCATION Education Secretary Considers Using Federal Funds to Arm Schools
Education Secretary Considers Using Federal Funds to Arm Schools
Education Secretary Betsy DeVos
The Education Department is considering whether to allow states to use federal funding to purchase guns for educators, according to multiple people with knowledge of the plan.
Such a move appears to be unprecedented, reversing a longstanding position taken by the federal government that it should not pay to outfit schools with weapons. And it would also undermine efforts by Congress to restrict the use of federal funding on guns. As recently as March, Congress passed a school safety bill that allocated $50 million a year to local school districts, but expressly prohibited the use of the money for firearms.
But the department is eyeing a program in federal education law, the Student Support and Academic Enrichment grants, that makes no mention of prohibiting weapons purchases. That omission would allow the education secretary, Betsy DeVos, to use her discretion to approve any state or district plans to use grant funding for firearms and firearm training, unless Congress clarifies the law or bans such funding through legislative action.
“The department is constantly considering and evaluating policy issues, particularly issues related to school safety,” said Liz Hill, a spokeswoman for the Education Department. “The secretary nor the department issues opinions on hypothetical scenarios.”
The $1 billion student support program, part of the Every Student Succeeds Act, is intended for academic and enrichment opportunities in the country’s poorest schools and calls for school districts to use the money toward three goals: providing a well-rounded education, improving school conditions for learning and improving the use of technology for digital literacy.
Department officials acknowledged that should the Education Department carry out the proposal, it would appear to be the first time that a federal agency has authorized the purchase of weapons without a congressional mandate, according to people familiar with the discussions. And while no such restrictions exist in the federal education law, it could undermine the grant program’s adoption of “drug and violence prevention,” which defines a safe school environment as free of weapons.
In its research, the Education Department has determined that the gun purchases could fall under improving school conditions, people familiar with the department’s thinking said. Under the current guidelines for that part of the grant, the department encourages schools to increase access to mental health counseling, establish dropout prevention programs, reduce suspensions and expulsions and improve re-entry programs for students transitioning from the juvenile justice system.
But the department began exploring whether to expand the use of the support grants after the school shootings in Parkland, Fla., and Santa Fe, Tex., prompted states to inquire about alternatives. Department officials were considering whether to issue guidance on the funding before the start of the new school year, but have been weighing the political and legal ramifications, according to people familiar with the discussions. Source Link
Education Department us
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The Middle Phinger
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Music Video News Rap / Hip Hop
Future Releases New Single “Crushed Up,” Reveals Album Release Date
January 6, 2019 matt 0
Future without a doubt had a super busy 2018. He linked up with fellow superstars like Tinashe, DJ Khaled, Jay Z, Beyonce, PARTYNEXTDOOR, Rae Sremmurd, Chance the Rapper, Nicki Minaj, and so many more. He also dropped a mixtape and a collaborative album with Juice WRLD. And now today, he starts the year just like he ended the last, with new music!
For a few weeks now, Future has been teasing his upcoming album. Now although he hasn’t revealed the album’s title, he recently took to social media to reveal that the album is set to be released later this month on January 18th! And in addition to sharing the release date, Future also shared a brand new single titled “Crushed Up.” The new single is accompanied by an equally epic music video. So check out the new single and music video, grab the download below, and patiently wait for his album to drop later this month.
Jan 18th album title TBA #FUTUREHIVE #ILOVEUMORETHANILOVEME #CRUSHEDUP 2019 bizness pic.twitter.com/8giCzo06I6
— FUTURE/FREEBANDZ (@1future) January 4, 2019
Download: Future – Crushed Up
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Arrow Video FrightFest 2018 Review - THE DARK
A young girl living a cannibalistic life in the woods comes to the aid of a kidnapping victim.
Review by Eric Hillis
Directed by: Justin P. Lange
Starring: Nadia Alexander, Toby Nichols, Karl Markovics, Margarete Tiesel
Writer/director Justin P. Lange's The Dark opens with a scene reminiscent of the Coen brothers in their darker moments. A fidgety man of indeterminate European origin (Karl Markovics) enters a backwoods convenience store, gathers up an armful of goods and heads to the counter, where a gruff, aging clerk proceeds to warn him off visiting 'Devil's Den', a local patch of woodland said to be stalked by a monster. The clerk has incorrectly assumed his customer is yet another thrill-seeking tourist, but he learns the truth when his TV set flashes up a headshot of the man, who we now learn is a wanted fugitive named Josef. Josef promptly pulls a gun, blowing away the clerk.
Figuring Devil's Den is as good a place to hide out as any, Josef heads to the secluded spot, where he comes upon a run down, abandoned house. Inside he finds the building decrepit, save for one bedroom, its bed freshly made up and its walls lined with charcoal drawings. Before he can catch some shuteye, Josef is attacked and killed by Mina (Nadia Alexander), an axe-wielding, feral young girl, whose face appears to have been torn to shreds as though by an animal as wild as herself.
After feasting on Josef's flesh, Mina investigates his car, where she finds Alex (Toby Nichols), a young boy who has been abducted by the fugitive and whose eyes have been crudely sewn shut. Resisting the temptation to feed on him, Mina agrees to help Alex find a phone to contact someone who can help him, but Mina is mistrusting of the adult world, meaning anyone they encounter along the way becomes a victim of her rage.
Mina and Alex are the babes in the woods of a particularly grim fairy tale. We never learn the exact details of what might have happened to Alex at the hands of his abductor, so we're forced to assume the worst. We do however, through flashbacks, learn Mina's backstory and the reason behind her aggression towards adults. Needless to say, it's bleak and disturbing.
Such darkness is tempered somewhat by the sweet relationship that develops between the two young abuse victims. The zombie-like Mina becomes gradually more human the more time she spends in Alex's safe, trustful company; her scars slowly healing and her taste buds becoming accustomed to regular food. Young actors Alexander and Nichols do a fine job of emoting through their heavy facial prosthetics and gaining the sympathy of the audience.
Lange developed The Dark from his 2013 short of the same name, which may explain why his feature length version can at times feel needlessly stretched out. After a gripping opening that keeps us on our toes and guessing where all this is headed, it does get a little bogged down when Mina and Alex set off on their journey to salvation, with flashbacks intercut with rote scenes of Mina knocking off enough humans to maintain the interest of any horror fans drawn to its premise by the prospect of bloodshed.
There's enough talent on display here to suggest that all involved will be responsible for more engaging fare in the future, from Lange, whose direction is commendably understated in even his film's wilder moments, to his young leads, whom I'm now curious to see deliver make-up free performances.
The Dark will receive a home-entertainment release in October, courtesy of FrightFest Presents.
Labels: By Eric Hillis, First Look, frightfest, horror, New Releases
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Pearl Jam Announce New ‘Gigaton’ Album + 2020 North American Tour
Photo: Melina Dellamarggio
The teasing is over — Pearl Jam have officially announced their upcoming new album Gigaton along with a 2020 U.S. tour. The rockers' eleventh studio album will be out March 27 on the band's Monkeywrench Records and Republic Records.
Gigaton marks Pearl Jam's first studio release since their 2013 effort Lightning Bolt, which gave us hits like "Mind Your Manners" and "Sirens." The first single from the upcoming album, "Dance of the Clairvoyants," will be released sometime over the next few weeks. Pre-order the album and single here.
"Making this record was a long journey," guitarist Mike McCready explains of the album. "It was emotionally dark and confusing at times, but also an exciting and experimental road map to musical redemption. Collaborating with my bandmates on Gigaton ultimately gave me greater love, awareness and knowledge of the need for human connection in these times."
In support of the new album, Pearl Jam will tour North America beginning in March in Canada, ahead of their European tour with Pixies, IDLES and White Reaper. See the new dates below. Tickets go on sale Friday, Jan. 24.
Monkeywrench Records/Republic Records
Pearl Jam 2020 North American Tour Dates
March 18 – Toronto, Ontario @ Scotiabank Arena
March 20 – Ottawa, Ontario @ Canadian Tire Centre
March 22 – Quebec City, Quebec @ Videotron Centre
March 24 – Hamilton, Ontario @ FirstOntario Centre
March 28 – Baltimore, Md. @ Royal Farms Arena
March 30 – New York, N.Y. @ Madison Square Garden
April 02 – Nashville, Tenn. @ Bridgestone Arena
April 04 – St. Louis, Mo. @ Enterprise Center
April 06 – Oklahoma City, Okla. @ Chesapeake Energy Arena
April 09 – Denver, Colo. @ Pepsi Center
April 11 – Phoenix, Ariz. @ Gila River Arena
April 13 – San Diego, Calif. @ Viejas Arena
April 15 – Los Angeles, Calif. @ The Forum
April 18 – Oakland, Calif. @ Oakland Arena
2020's Most Anticipated Rock + Metal Albums
Source: Pearl Jam Announce New ‘Gigaton’ Album + 2020 North American Tour
Filed Under: pearl jam
Categories: Concerts, News, Newsletter
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Dolly Parton Loves Comedy Because It ‘Helps You Through the Hard Times’
In addition to her unparalleled songwriting skills, Dolly Parton has displayed some serious comedic chops throughout her career. The singer says she honed her funny bone by learning from some of the other artists in her circle.
"Minnie Pearl was a dear friend of mine, and she was a very classy lady," Parton recalled during a recent press conference. An iconic Grand Ole Opry mainstay and country comedian, Pearl was known for her down-home delivery. However, Parton points out, "She was very intelligent, very educated, but she just put on that whole garb with her little hat so she could do that corny country comedy that people love."
Pearl's cornball aesthetic tapped into a kind of humor particular to country music's audience, Parton goes on to say. That brand of comedy is similar to Parton's own, which has always been a big part of her musical career and her personal life.
"Because this is about country people, people back home working on the farms and milking their cows and doing whatever -- they love laughing," the singer continues. "They love to have something to listen to and laugh about, and the type of humor they understand. I think most country people, and most entertainers like myself, comedy is part of our being because it's kind of what helps you through the hard times growing up."
In fact, she says, perhaps the biggest influence on her style of onstage humor comes from her upbringing. "We made more fun of stuff that you probably shouldn't even laugh at, but that was the funniest stuff," Parton remembers. "We tried to find the humor in it, even though it was about because somebody was sick, or whatever. You'd find something silly to say about it.
"I just think it's important for people to laugh," she concludes. "I grew up in a family where my dad's people were absolutely hysterical. My mama's people, too. So I get that from them. We're just naturally funny -- we think!"
10 Things to Know About Dolly Parton
WATCH: 11 Unforgettable Dolly Parton Moments
NEXT: Top 10 Dolly Parton Songs
Source: Dolly Parton Loves Comedy Because It ‘Helps You Through the Hard Times’
Filed Under: Dolly Parton, Editor's Picks
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Health department confirms 148 flu deaths in North Carolina so far in the 2018-19 season
RALEIGH (WTVD) -- A total of 148 people in North Carolina have died from the flu this season, according to the North Carolina Department of Health and Human Services.
The latest flu numbers were released March 16.
Over the last recorded week, there were seven new flu-related deaths.
In North Carolina, 391 flu deaths were reported during the 2017-2018 flu season -- the most reported during a flu season since adult flu deaths became reportable in the state in 2009.
Of those 391 deaths, 290 were people age 65 and older and seven were children under the age of 18.
Duke Pulmonologist and Critical Care Physician Dr. Talal Dahhan said that unfortunately, many patients who are contracting the flu are becoming seriously ill and landing in the hospital.
"We have had a significant number of referrals for critically ill patients who need advanced mechanical ventilation and sometimes extracorporeal support or what we call ECMO," Dr. Dahhan said.
The department of health defines a flu-related death as a "death resulting from a clinically compatible illness that was confirmed to be influenza by an appropriate laboratory or rapid diagnostic test with no period of complete recovery between the illness and death."
Officials sound warning after one of the state's 'deadliest' flu seasons
Flu season is here, and North Carolina health officials are urging residents to get vaccinated.
Officials are already reporting that influenza cases are higher than this time a year ago.
The CDC recommends vaccination against the flu for everyone 6 months and older.
"Vaccination, vaccination, vaccination is the most important," Dr. Dahhan said.
He said a flu shot is still your best defense and that the available vaccine actually works very well against most strains.
"There are anti-viral drugs to control the viral load rise and they are available and they work better if we recognize the influenza virus early to control the disease."
How to tell the difference between a cold and the flu
Extreme fatigue, high fever and chills are textbook markers of the flu.
health & fitnessncvaccinesfluflu death
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Home / What guides us / Special Olympics brings a family closer
2018 Special Olympics Brings a Family Closer
The Zamansky brothers competed at the 2018 Special Olympics USA Games in Seattle.
Play Special Olympics athletes Eric, Andrew and Alex Zamansky video
special-olympics-zamansky-brothers defaultPlayer true black /assets/images/special-olympics/Zamansky_Video2.jpg|Zamansky brothers|Special Olympics athletes Eric, Andrew and Alex Zamansky ||
TITLE CARD: Bank of America PRESENTS
TITLE CARD: BROTHERS
[Lesley Zamansky]
You know, we never labeled them when they were little. We didn’t say “Oh you have this, you have this, you have this.” They were just kids.
SUPER: Lesley Zamansky
I had four boys. Twelve years apart. And, you know, a lot of people in a small space. You have to be a team. You have to get along.
[Andrew Zamansky]
Well, Eric, he’s outgoing.
[Eric Zamansky]
Andrew is the quiet one. Alex is like a teddy bear.
SUPER: Alex Zamansky
SUPER: Andrew Zamansky
SUPER: Eric Zamansky
Unless, you know, you get him a little upset. Then he turns into a grizzly bear.
SUPER: DEC. 4. 1991
They’ve had their moments, and literally knockout brawls like boys will do. But at the end of the day, everybody is there for one another.
SUPER: 4:41 PM JUL. 28. 1996
[Alex Zamansky]
It’s amazing how strong of a bond we have together as brothers, and it shows on the field as well as at home.
I love these – I love, you know, my brothers. I would, you know, do anything for them.
Eric was born with cerebral palsy. Eric does so much more than he physically or intellectually should be able to do because nobody ever told him he couldn’t. It will be two years in March since he’s had his job at the Lawrence Eagle-Tribune. This is, you know, his first long-term job. I give him a lot of credit because it’s not easy for him.
Oh, it’s fun. We goof off as coworkers, but we also get the work done. It’s like a huge, huge team.
[Flag Football Team]
1, 2, 3, Haverhill!
This is big. This is, you know, they’re going to Seattle.
When we practice football, we leave the goofiness aside and we do our job. Hopefully we bring back gold for the state of Massachusetts.
If you were talking to me before the football, I would be totally crying. I would, like, look away, I would, like, probably hide away in my room and I would not talk. For me to have autism, it was really hard for me to, to socialize with people.
But with Special Olympics, there’s flag football, I can finally, like, socialize with people.
You know, they struggled with confidence. Special Olympics gave them confidence. When you have kids that struggle, there’s not many moments in the sun. So, to have this moment, it’s life-changing.
The excitement is off the charts in this house. You know, “I’ve never been out west! How long do you think the plane ride is?”
It’s the biggest opportunity we’ve ever had in our life.
This is from 1991. May fourth.
SUPER: SPECIAL OLYMPICS ERIC
I can’t even imagine Special Olympics not being in Eric and Andrew’s life. It’s everything.
You just have to slam, and bam, you’re right open.
As a mom of kids with varying types of disabilities, it’s hard watching your child struggle.
And I remember their heartaches, and their frustrations, and their temper tantrums and the bullying. They stick with you. So, to see my now grown men be part of something, I can’t even begin to tell you how happy I am that they get to tell their story. And their story is just as important as anybody else’s.
You put me, Alex, you, and Noah on a team, okay? Four on four. Who’s going to beat us? No one’s going to beat us.
SUPER: #PICKUPHOPE
LOGO: USA GAMES | SOI | Bank of America
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On and off the field, the Zamansky brothers are a team.
The young men are members of the Haverhill Angels, a Special Olympics flag football team from Massachusetts. Eric, 32, who has Cerebral Palsy, is a wide receiver. Andrew, 28, who is autistic, is the quarterback. Alex, 24, plays with the team as a Unified partner and is the defensive star.
“They just love all sports,” said the boys’ mother, Lesley Zamansky. In addition to football, they’ve played baseball and basketball, and Eric played football in high school.
“These athletes, all they want to do is be included,” said the Angels’ coach, Jay Barnes. “They want to feel accepted; they want to compete.”
The Angels even have a signature play: on the game’s opening drive, Eric will race down the field and Andrew will try to hit him in the end zone, right from the first snap.
“Coach Jay, he likes to call the play ‘the bomb,’” said Eric.
“It shows off how good my arm is,” quips Andrew.
The success on the field - they won the state title at the home stadium of the New England Patriots - has made all the boys more confident, especially the team’s field general, Andrew.
“Andrew has definitely benefitted the most,” said Lesley Zamansky. “He's gone from this boy who didn't say a word to somebody who's very, very vocal.”
“With sports, I can connect with other people in a way that I just couldn't before,” said Andrew. “It makes me happy, and playing with everyone else, it's just fun.”
The Angels competed in the 2018 Special Olympics USA Games in Seattle, Washington. Bank of America was a Platinum Partner of 2018 Special Olympics USA Games and has a long-standing relationship with Special Olympics, dating back over 30 years. It’s all part of the bank’s ongoing commitment to achieving the goal of a more diverse and inclusive society. And that goal is incredibly personal to the brothers, who get to play together on the same team - Andrew and Eric as athletes and Alex as a Unified partner.
“[They’re] all together,” said Lesley Zamansky. “And that's really what's most important.”
“These athletes are true leaders,” said Coach Barnes. “They help mentor my younger kids. They get right in, they start with drills with them, and it's great to see that these athletes have so much unconditional love to give.”
Off the field, the Zamansky’s are a tight-knit crew. Andrew is the official baby sitter for Eric’s young son while his brother works a day job in the Lawrence Eagle-Tribune’s printing facility.
“I love my brothers,” said Eric. “I would do anything for them.”
The entire Zamansky family is grateful for the impact Special Olympics has had on their lives - and how sports have positively impacted their lives as a whole.
“I learned as teammates that when we’re working together, and we're in sync with each other, we feel like nothing can break us, that nothing can stop us, that no one can beat us,” said Alex.
“My athletes are definitely better people because of this,” said Coach Barnes. “I want them to come back. I want them to take what they got out of Seattle, and I want them to put it into use, either coaching, or in their family lives or even in their community.
Whether on or off the Unified Flag Football field, these brothers support each other until the end.
Focused on the challenge ahead, the Zamansky brothers put their best play forward on the field.
The Zamanskys exemplify sportsmanship by handing out high fives after the game.
Noah Zamansky receives the bronze medal for flag football alongside his brothers.
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Prague Castle: Small Group Tour with Local Guide & Admission
4.7 / 5 856 Reviews
A GetYourGuide Original
The ultimate tour experience
Unforgettable local guides
Hidden highlights
Full refund if you didn't enjoy the tour
Love where you're going, guaranteed
With a GetYourGuide Originals tour, you can enjoy complimentary rescheduling if you’re late or plans change, and a full refund if you’re not completely satisfied after taking your tour.
Led only by 5-star guides and local aficionados, you can expect intriguing insights, fun facts, and stories from the people who call your destination home.
A maximum of 20 people on your tour, which means you'll enjoy a more interactive, personalized experience.
Top sights (and hidden ones, too)
On an Originals tour, you'll discover lesser-known treasures that other visitors often miss, bringing you a deeper understanding of your destination.
Priority access — more time to explore
Long line? We'll show you how to skip it. Packed out sights? Follow us to the secret quiet spots. On Originals tours, you can explore in ways that others can't.
About this tour
The Original experience
Hear expert commentary from your local guide
Enjoy the convenience of skipping the ticket line and using the short security line
See St. Vitus' stained glass, tombs and chapels
Explore the Old Palace and see the Vladislav Hall
Listen to your guide through headphones
Visiting Prague Castle is like walking into a fairy tale. See the highlights of the castle complex including St. Vitus Cathedral, the Old Royal Palace, St. George’s Basilica, and the Golden Lane. The Castle contains an overwhelming amount of history and art, but thanks to your local expert guide, you'll navigate the castle grounds with ease. Meet your guide in front of the Malostranská metro station near the Mánes Bridge. From there, take the tram up to Prague Castle. Once inside, your guide will give you headphones so that you can easily hear their commentary throughout the tour.
Marvel at St. Vitus’ Gothic architecture. Spot the gargoyles that adorn the exterior of the church. Be dazzled by the Art-Nouveau stained glass window made by Czech artist Alfons Mucha. Admire the 14th-century mosaic of the last judgment. See the tombs of St. Wenceslas and Charles IV, the baroque tomb of St. John of Nepomuk, and the Chapel of St. Wenceslas.
Next, enter the Old Royal Palace. Stand under the massive vaulted ceiling of the Vladislav Hall. The lines of the vaults meander in an almost floral pattern, giving the hall a sense of lightness. Enter the chamber where the Defenestration of Prague occurred. Here the Czech Protestant aristocrats threw the Catholic governors of the Habsburg emperor and their secretary out the window, starting the Thirty Years War.
Visit the Basilica of St. George. The stone walls and design of the basilica offer a counterpoint to the grandiosity of the castle. See the fragments of 12th-century frescoes and then walk up the double staircase where the remains of St. Ludmila lie.
Walk along the Golden Lane. The cottages in this alley were originally built for the castle’s sharpshooters, but later housed goldsmiths. In later centuries artists like Franz Kafka lived there. Examine the reconstructed workshops and homes of the Golden alley. See how the working people of Prague lived in the shadow of the castle.
Tram ticket
Admission ticket to Prague Castle (including St. Vitus Cathedral, the Old Royal Palace, St. George’s Basilica and the Golden Lane)
Expert local guide
Use of short security line
Meeting point varies depending on option booked.
Small Group Tour in English with Local Guide & Admission
Small Group Tour in German with Local Guide & Admission
• Please note, on occasions of state visits, parts of the castle might be closed to visitors
Prague Castle 2.5-Hour Tour Including Admission Ticket
Prague Castle Ticket and Introductory Overview
Lobkowicz Palace and Prague Castle Entrance Tickets
Best of Prague By Foot and Bus, and 1-Hour River Cruise
Fun in Prague
Rome Walking Tours
Dubai Day Trips
TV Tower
Oskar Schindler's Factory
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Some Impressions from the Stereo 3D Mode in Crysis 2 Multiplayer Demo
March 2nd, 2011 · 25 Comments · Stereo 3D Games
Yesterday was the day that the Crysis 2 multiplayer PC demo was released, but half of the day it was unplayable do to the MyCrysis servers being overloaded from the big user interest and people were unable to register and try the game. But now everything is fine and you can try the game to get some idea on what you can expect from the full game expected to e released at the end of this month. Of course the game supports stereo 3D on a native engine level, but it is compatible with 3D Vision and 3DTV Play, however the stereoscopic rendering is not being done by the 3D Vision drivers, but the game engine itself and 3D Vision is just being used for the visualization. The idea is that the game engine does not render two complete frames from two different views to produce the S3D effect and thus the performance drop is not that big when switching between 2D (plain 3D) and stereo 3D mode. In the Stereo 3D game menu of the demo you don’t have an option to switch to 3D Vision rendering for example or to choose the native S3D rendering, so it is hard to compare the difference, but the game in stereo 3D mode still looks nice with the game developer’s approach.
The video options settings are not very advanced in the demo, you can pretty much switch between different resolutions and a fer preset profiles for the detail level, but hopefully the full game will have more advanced options for the Graphics settings here. The Hardcore mode is the heaviest in the demo and with a Intel Core i5 2500K Sandy Bridge processor running at 5GHz and a single GeForce GTX 580 in stereo 3D mode the demo manages to provide an average framerate of about 55 frames per eye and the framerate is not dropping below 50 fps per eye. The same setup, but with two GeForce GTX 580 video cards in SLI (only the CPU is overclocked, the video cards are at stock frequencies) in stereo 3D mode the game freezes at a constant framerate of 60 fps per eye. It is possible however that the final full game may offer even heavier graphics options, but two GTX 580s in SLI should be able to handle even these (if you have SLI, make sure you update to the latest SLI profiles).
Strangely enough I even managed to get see a health warning once while going through the options for the game, but not the first time I went into the stereo 3D settings and after that I could not get to it again, so here is a screenshot about the warning in the game for prolonged play in stereo 3D mode. The recommendation says you should take 15 minute brake every hour of gameplay, something that might be a bit of a problem when playing online in multiplayer mode. There is also a warning regrading small children – six years old or younger that should not play without their parents first consulting with a doctor…
→ 25 CommentsTags:3d vision·3dtv play·crysis 2·crysis 2 3d·Crysis 2 3D Mode·Crysis 2 Demo·Crysis 2 Multiplayer Demo·MyCrysis·stereo 3d
The Offical Crysis 2 Multiplayer Demo is Out Now with S3D Support
March 1st, 2011 · 12 Comments · Stereo 3D Games
EA has finally released the official PC version of the Crysis 2 multiplayer demo, and it is already available for Xbox 360 as well, with a PlayStation 3 demo also coming soon. The Crysis 2 multiplayer mode demo includes two maps – “Skyline” and “Pier 17” in the war-torn Manhattan, as well as two gameplay modes – “Team Instant Action” and “Crash Site” with the final game expected to include much more of course. The “Team Instant Action” mode puts two teams against each other with the ultimate goal of killing as many opponents as possible in order to win the round and in the “Crash Site” mode players will battle for control of alien drop pods, earning points by guarding their pods and keeping enemies at bay. The full Crysis 2 game will be available for the Xbox 360, PlayStation 3 and PC on March 22 in North America and on March 25 in Europe.
And now, regarding the stereo 3D support in the demo. We already know that the game has its own native implementation for stereo 3D support that is supposed not to lead to significant framerate drops when in S3D mode as compared to playing in plain 3D mode. But at the moment the interest in the demo is probably so big, that the MyCrysis website is overloaded with requests for registrations and longins from users that it is almost constantly timing out, leaving new users wanting to try the demo unsatisfied. So I’m still trying to get pass the login screen of the them for a while now to try the demo in stereo 3D mode, but if you’ve already managed to test it, then please share your comments below…
– For more information and download locations for the PC demo of Crysis 2…
→ 12 CommentsTags:3d vision·crysis 2·crysis 2 3d·Crysis 2 Demo·Crysis 2 Multiplayer Demo·MyCrysis·native stereo 3d
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Can You Believe ‘Glee’ Turns 10 this Year?
Posted on Jan 21, 2019 Jan 22, 2019
Desiree Pore
When we entered 2009, which was exactly 10 years ago, there was this little show on television that would forever cement its legacy in pop culture.
Glee basically had a cliché plot involving high school students and their love for show tunes. Nobody expected it to be such a huge success, earning legions of fans worldwide, but thanks to the creative arrangements of our favorite tunes and pop songs, we were hooked. Yes, there was a decline in popularity towards its latter seasons, but during its peak almost everyone you knew was watching the show. The word Gleek had been etched forever in our consciousness.
10 years on, Glee’s legacy continues to live on thanks to these memorable pop culture moments:
It Gave us the Iconic Don’t Stop Believin’ Performance
The performance that started it all. On its pilot episode, newly-transferred high school teacher Will Schuester tried to establish a ‘glee club’ by recruiting students whom he saw had potential. Enter the “New Directions”, a group of kids from different social cliques who came together for the love of performing. This earworm from Journey became a staple in the show, having been performed six times throughout its 6-season run.
This Emotional Tribute to the OG Quarterback
Cory Monteith, who played Finn Hudson in the show, tragically died right before season 5 started filming. The third episode, aptly titled “The Quarterback”, was dedicated in memory of the actor and the character, with previous and current cast members giving their own tributes throughout the episode. Without a doubt Lea Michele’s (who was dating Monteith in real life at the time) performance of Make You Feel My Love was the highlight of the episode, thanks to her raw and honest vocals.
They Introduced us to Darren Criss
It was through Glee that the world was introduced to the talented Darren Criss. Criss’ character Blaine Anderson stole everyone’s thunder whenever he’s on screen, making him the top breakout star from the show n its second season. Currently, Criss has been earning praises and awards for his role in American Crime Story.
They Defied Gravity
It wouldn’t be a show about singing show tunes without singing some classic favorites! This performance of the signature Wicked song Defying Gravity between Rachel (Lea Michele) and Kurt (Chris Colfer) is definitely one of the highlights of the show.
“The Power of Madonna”
Madonna is one of the best artists of all time, so it’s just right for a musical show to dedicate a whole episode to the Queen of Pop. The definitive highlight of the episode was the performance of the show’s antagonist Sue Sylvester of one of Madonna’s iconic song “Vogue”, along with its iconic video.
They Went Full Gaga
Another music icon was given an equally iconic performance in the show. Given a Gaga assignment, the girls of New Directions chose to perform Lady Gaga’s “Bad Romance” with matching memorable outfits. Too bad the meat dress wasn’t present.
This “Smooth” Performance
A tribute to the King of Pop was given on the show’s third season; New Directions and rival glee club The Warblers went head to head when former Warbler captain Blaine was badly injured after a battle. To avenge her friend, Santana (Naya Rivera) challenged current Warbler captain Sebastian Smythe (Grant Gustin) to a duel. And that duel turned out to be one of the best performances from the show.
They Helped Popularize Fun.
The cast of Glee helped fun.’s signature hit “We Are Young” become a global hit, thanks to their performance of the song in the show’s third season. The New Directions’ heart-warming performance of the song was the perfect way to cap off the episode.
What’s your fondest memory of the show? Tell us below!
Don't stop believing. Cory Monteith
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Jenna Dewan Denies Calling Camila Cabello ‘Extra’ During AMAs Performance
Matt Winkelmeyer/JC Olivera, Getty Images
Jenna Dewan responded to rumors that she shaded Camila Cabello at the 2019 AMAs.
On Sunday (November 24), the dancer-turned-actress was met with backlash after video footage of what appeared to be her calling the "Living Proof" singer "extra" started circulating online. The moment was captured during Cabello's "Senorita" performance with Shawn Mendes after the couple bought their steamy collab to life once again.
In the clip, fans believe the pregnant star whispered "she's always so extra" to celebrity stylist Brad Goreski, who was standing next to her, and some even swear she rolled her eyes while saying it.
Disclaimer: As Amazon Associates, we earn on qualifying purchases.
However, Dewan has since set the record straight on her Instagram Stories. She not only clarified that there was definitely no shade being thrown, but she said she has nothing but love for Cabello.
"I’m getting a lot of text messages wondering if I was shading Camila," Dewan insisted. "No, I love her so much! I'm such a big fan of hers. I don't understand what that's about but no, I love her, love her, love her."
Goreski also chimed in, saying, "Guys, we were bumping and grinding so hard to 'Senorita.' We’re obsessed."
"That’s my favorite song!" Dewan added. "So crazy! Anyways, clearing it up."
2019 AMAs Red Carpet
Source: Jenna Dewan Denies Calling Camila Cabello ‘Extra’ During AMAs Performance
Filed Under: Camila Cabello, Jenna Dewan
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The People may argue that the amateur ethos
The Gaelic Athletic Association (GAA)
is the sporting organization in Ireland that represents all Gaelic Games played
in Ireland and abroad with more than 500,000 members internationally. With the
rise of Gaelic games popularity, this report will highlight how it’s essential
to give players that represent their county at the elitist level within the GAA
a basic wage.
Given the demands put on players these
days, to be involved at the inter-county level it has become a professional
sport. The money being the only thing keeping it under the label of an amateur
sport. There must be a change and the players need more support, or it will
quickly get out of hand and the GAA will lose even more players to other
sports. Players representing their county can be training up to 10 months of
the year. While there is a winter rule in place where it states no county,
teams can train over winter months this is repeatedly broken as counties have
to maintain an elevated level when competing with other counties. These players
could be working in cities and have travel home up to three times a week not
only putting a serious strain on their work lives but a serious stress on their
welfare. It can be seen why that many county players consist of a lot of
students or teachers these days. Many players holding full-time jobs have had
to opt out of playing due to it not being realistically feasible.
People may argue that the amateur
ethos central to its survival as it would lose its sense of community spirit
that is so unique to the GAA, but people must see it is a Professional sport.
Elite players are putting their bodies on the line as they do not just turn up
to play. They have multiple trainings in a week, numerous gym sessions and
their diet must be impeccable to maintain their bodies and prevent burnout
which is an occurring issue in GAA. If you look at sports like Rugby or
Cricket, you can see everything about the GAA shouts out professional sport as
there doing the same or even more than some other professional sports.
The GAA is operating to a broken model
and the players deserve more than this. The GAA has assets of more than 2.6
Billion while the players representing their counties currently get a pitiful
grant of less than €1,000 a year for their efforts. Compare this to the
president of the GAA gets around a hundred thousand euros per annum. Without
the players, there be no GAA, so it must be considered that they introduce
basic wage to these players.
This has is a major issue for the GAA
because young talent has chosen the discipline in which they will earn a salary
rather for the love of the sport. It’s an easy choice for these young stars.
Would you rather get paid for playing rugby and soccer or train multiple times
a week risking your welfare? It must change sooner rather than later.
Notes on the Economics of Game Theory
Clitoral hypertrophy
Sports salaries
Are removal of errors or to alleviate stress
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The Case for Smart Phones in the Developing World
tags: android, coltan, google, smart phone, technology
From a longer write up by the Guardian, but the words here are by Google’s Andy Rubin (their head of Android):
Historians are, however, going to make note of how the open source Android platform (or its later forks and clones) played a role in facilitating everything from low-cost solar-powered devices in the remotest villages in India and Africa, to a hundred million tablets computers in the classroom each revolutionizing education for children all across Asia and the Middle East, to putting an internet-connected smartphone in the hands of every man, woman, and child in America, even those from the perpetually overlooked majority that simply can’t afford a shiny brand-new iPhone or Galaxy Nexus every Christmas.
So ultimately I don’t give two hoots about which vendor or which carrier gets to ship which device on which network with which apps. But I’m stunned, stunned, by the audacity of releasing the Android platform as free and open source software. Not just because how it has already shaken things up at the top. But how it will go on to shake the rest of the planet upside down.
Agreed. Now all we’ve got to do is address the Coltan issue in making all those phones.
from → smart phone future, technology evolution, the business of digital media, The Future
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Video Games Predictions for 2012 – The Console Wars →
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http://ahval.co/en-51085
Turkey’s ruling party votes down inquiry into China’s repression on Uighurs
Jun 21 2019 05:17 Gmt+3
Last Updated On: Jun 21 2019 05:24 Gmt+3
Turkey’s ruling Justice and Development Party (AKP) voted against an opposition motion for a parliamentary inquiry into China's oppressive practices against its Turkic Muslim population, Euronews reported on Friday.
Aydın Adnan Sezgin, a deputy for the nationalist opposition Good Party, submitted the motion asking for an investigation into repression against Uighur Turks under Chinese rule.
The AKP voted against the motion while its far-right nationalist ally Nationalist Movement Party (MHP), known as an outspoken supporter of China's Uighur Turks, abstained from the vote.
After remaining silent for years on China’s treatment of Uighurs, Ankara called on China in February to close the camps, describing them as a “great cause of shame for humanity”. Turkish Foreign Minister Mevlüt Çavuşoğlu urged Beijing to protect freedom of religion and cultural identity during a U.N. Human Rights Council in Geneva on February 25.
China has faced international condemnation in recent months over the internment of at least one million Uighurs in so-called re-education camps in Xinjiang.
Uighur people are subject to intense surveillance, are forced to give DNA and biometric samples and learning Mandarin Chinese, and prohibited from criticising or renouncing their faith at the internment camps in the Xinjiang Uighur Autonomous Region, according to Human Rights Watch.
Turkey’s relations with China have blossomed in recent years with Ankara negotiating massive infrastructure deals with Beijing, ranging from high-speed railways to nuclear power plants. China loaned it $3.6 billion to fund infrastructure projects last year, when Turkish lira hit record lows in August due to a diplomatic spat with Washington over the almost two year detention of an American pastor.
Turkish President Recep Tayyip Erdoğan last week attended the fifth summit meeting of the Conference on Interaction and Confidence-Building Measures in Asia (CICA) in the Tajik capital Dushanbe and stated that Turkey aimed at deepening relations with Asian countries.
Chinese President Xi Jinping called on CICA members to explore a regional security structure with Asian features to realise collective security for Asia.
https://tr.euronews.com/2019/06/21/uygur-turklerine-yonelik-baskinin-arastirilmasini-isteyen-onerge-reddedildi
Uighur children alone in Turkey as parents arrested in China
Turkey’s Uighurs fear repatriation to China - NY Times
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Alasandro FEnSTON is aN up-and-coming filmmaker and Photographer
based in New York City
Meet Alasandro
Alasandro has a formal business background and recently switched from the finance world into the film industry. His producer debut was on the short film, “88 Cents” where he had a hand in all areas of production and managed a cast and crew of 106 people.
He is now living in New York, working with a number of producers on short and featured length films as well as some work in reality TV.
As a creative producer, Alasandro takes an integral role in all stages of production, working in both the creative development stages as well as final edits.
On set, he manages cast and crew with ease and allows for an efficient and enjoyable work flow. This comes from an understanding both creatively as to what vision needs to come to life and operationally, what needs to be done to get there.
Alasandro would like to continue to develop his producer skill set with other collaborative and creative minds. He hopes to continue to create meaningful works with talented partners.
If you’d like to speak with Alasandro today, he can be reached at 929-359-3269.
Cannes Short Film Corner – Official Selection
LA Shorts Awards – Best Film – Gold Award
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Mindfield Film Festival – Los Angeles – Best Short Film – Diamond Award
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© 2017 ALASANDRO BRIX FILMS | 35 SCHERMERHORN STREET, STE 7, BROOKLYN, NY 11201 | 929-359-3269
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Take Down Requests
The mystery of the Solway Spaceman
By Anomalien.com
On May 23rd, 1964, Jim Templeton, a firefighter from Carlisle, Cumberland, made 3 photos of his five-year-old daughter while on a day trip to Burgh Marsh, located near Burgh by Sands and overlooking the Solway Firth in Cumbria, England.
In accordance to Templeton, they were alone that day save for a handful of cows and sheep in a nearby pasture. He took a few pictures during the outing. You might not recall the days before digital photography, but it used to be that you would to take your rolls of exposed film to a developer and wait for them to be returned.
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The only other people reported on the marshes that day were a couple of old ladies, and although cows and sheep would have normally been plentiful, they were huddled together at the far end of the marsh.
When he picked up the finished photos, the developer commented, “that would have been a real nice photo of Elizabeth if that man hadn’t been standing back there.” Templeton didn’t understand what that was supposed to mean until he saw the picture.
Templeton insists that he did not see the figure until after his photographs were developed, and analysts at Kodak confirmed that the photograph was genuine. To this day, the picture remains unexplained and a source of international fascination.
After the publication of the photo in the newspaper, Templeton claims that two men showed up at his home. He described them as being dressed in what is now known as the stereotypical “Men In Black” look. They claimed to be agents of the British government but refused to produce any identification. They referred to themselves only as “#9” and “#10.
“They drove Templeton to the area of the marsh where the photograph was taken and asked him to describe the day to them, paying particular attention to weather conditions and “the behavior of area birds.” That done, the two MIBs insisted that Templeton merely photographed a passerby. When Templeton continued to express disagreement with this assertion, the MIBs grew noticeably angry and drove off, leaving Templeton in the marsh with nothing but a bewildered feeling and a five mile walk home.
When the picture was taken, in 1964, human space suits were in their extreme infancy. It has been suggested by some people that the figure is merely someone with their back to the camera, perhaps wearing a hat or helmet.
The men tried to make Templeton admit that he had photographed a person, but he refused. In the same time frame that the picture was taken, a Blue Streak missile launch at the Woomera Test Range, using Cumbrian-built weaponry, was aborted because of two large men who were witnessed on the firing range.
This was long before the time of Photoshop, so that lends credibility. What’s more, the Kodak Camera Company examined the film and pronounced it to be authentic not tampered with. Could this all be an elaborate hoax on the part of Jim Templeton? After all, we have only his word about there being no one else being at the marsh that day as well as for the visit from the MIBs.
Giichi Shiota Encounter With Alien Cosmonaut
But if it was his own concoction, what did he gain from it? A bit of fame that was short-lived. Any monetary gain he had was slim if not non-existent. If anything, he probably had to endure more ridicule than benefit. Then there is the added weirdness of the Australian missile test.
The technicians reported that the figures resembled the Solway Firth Spaceman. Ufologists have used the photograph as evidence that extraterrestrial life has influenced the modern day space program, including space suits.
Source: strangeworldofmystery.blogspot.com
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14 Dec 2011 15 Jul 2019 ~ Anthony Sacramone
The earth is evil. We don’t need to grieve for it. Nobody will miss it.
There may be life somewhere else.
But there isn’t.
It’s a comedy, you see. Or at least I hope so. Because if Melancholia, the much-ballyhooed dirge from controversial Danish filmmaker Lars Von Trier, is intended to be tragedy, then we have here a disaster that makes the German Peasants War of 1524 look like an episode of Curb Appeal.
Cold open. Very cold. Deep space. Deep, deep space. Planets. Colliding. People. Fleeing. Nature. Unhinged. A bride. Entangled. In tree roots. Everything. Moving. Slowly. Until. Planets. Go. Boom. Blackout.
A terrifying dream? The nocturnal effluvia of a melancholic personality? Or a presage of terrible things to come, a foreordained and predestined end of everything. Make that Everything.
Justine. Played by Kirsten Dunst. It’s her wedding day. She and her groom are two hours late to the reception owing to the incompetence of a limo driver who won his license at a Middle School raffle.
Justine’s sister, Claire, played by the painfully pained Charlotte Gainsbourg, is more angry than relieved, having gone to great pains to create a party to end all wedding parties at an estate that features an 18-hole golf course and onion soup. Justine’s mother (Charlotte Rampling) is a bitter, pissy woman who declaims to all the attendees how she hates marriage, which is why she didn’t go to the church. And who can blame her, when her ex husband (the great John Hurt), has shown up with two dates, both named Betty.
Justine’s boss, Stellan Skarsgard (real-life dad of Alexander, who plays the pathetic groom), is the head of an advertising agency and offers her as a wedding gift a promotion to art director from that of copy writer. There’s just one catch: he needs a tagline for a new ad campaign. Before the honeymoon begins. In an hour of so. And to ensure that he gets the goods, he has just hired his nephew to get that tagline out of the otherwise preoccupied Justine before evening’s end, lest he lose said job.
So how is Justine holding up under all this wackadoodle? Not well. She is trying, poor thing. Putting on a brave face. Insisting that this extravagant celebration is exactly what she wanted. Then why does she keep walking out? Why does she leave the table to go take a bath? Why does she leave her poor schmuck of a clueless husband to hump the boss’s nephew on the golf course? Why does she then tell the boss off in a fit of worker revolt not seen since Keep the Aspidistra Flying?
Why has she used her wedding day to blow up everything “good” in her life?
Because life on earth is evil.
After the wedding guests have all gone home, Justine plunges deeper into near catatonic depression, to the point where she can’t even bath herself without help from Claire. Her put-upon sister, too, is limp with anxiety, not only because her sibling, who she hates as well as pities, can’t help checking on the progress of that planet seen in the opening sequence, subtly called Melancholia. Is it going to hit planet Earth, or simply provide a once-in-a-lifetime fly-by, as her fabulously wealthy scientist husband (Kiefer Sutherland) insists.
And so we wait. Is science right? Will earth survive this near calamity of flirting orbs? Or will all on Earth be reduced to ashes, rendering the best and the brightest a bunch of boobies who can’t even get the Apocalypse right? And if so, what were all those putative good things — like love and family and work and estates with golf courses and onion soup — for? What did they mean? Were they always meaningless, as Justine and Claire’s mother never tires of declaiming? Or do they just become meaningless in the face of mass extinction, which is just personal extinction with more running around?
Melancholia is an exercise in crapulous angst — not to be mistaken for existential angst. A tipsy filmmaker, a poor man’s Ingmar Bergman, assuming that poor man was Woody Allen on the set of Interiors, has decided to exorcise his demons by giving Charlotte Gainsbourg a role in which she’s not forced to perform her own clitoridectomy. Instead, the audience is forced to perform a lobotomy, at least if they’re to take the critics’ fawning over this empty pretentious twaddle seriously.
As for Kirsten Dunst, who won Best Actress at Cannes: She’s suitably morose and self-absorbed. And she’s nude in two scenes. And she stares out into the distance with an intensity not seen since Deepak Chopra’s cameo in The Love Guru. If she beats out Meryl Streep’s sure-to-be-spot-on but soulless imitation of Margaret Thatcher in The Iron Lady, I’ll punch a mime.
How seriously are we supposed to take these empty, two-dimensional, dullwitted characters? If they’re truly representative of humanity, at least a humanity with a net worth in the mid eight figures, who wouldn’t want to see them obliterated? Even their pain is boring. That’s the problem with a “dramatic” exercise in the meaningless of all things: your attempt to be meaningful is itself meaningless.
Don’t look for any religious undertones or spiritual yearning or even last-gasp efforts to seek the will or face of God. This universe is as empty as an Episcopal church on Stewardship Sunday. The very last image, of Justine, Claire, and Claire’s little boy huddling together under a teepee configuration of sticks with no external covering, is supposed to sum it all up in some pathetic way: all our attempts to hide from reality are merely so many twigs in a tornado. OK. Thanks for sharing.
This could have been an intriguing look at clinical depression from the inside — you feel like the world is coming to an end and you just don’t care about anyone or anything and why won’t it all end already. That may have been what initially motivated Von Trier, given statements he has made in interviews. The finished product, however, is not that. It’s clinical depression as the only grown-up way of looking at life full stop. And the only reason I don’t kill myself is because you won’t all join in and thus confirm how smart I am.
Again, I tried to imagine this as a comedy whose punchline was “Beware happy people, they don’t have enough information.” And perhaps Von Trier is, in fact, having us on. He’s known for being a prankster, pulling the public’s whiskers for a laugh.
Or maybe this is just a piece of sullen, sulky dribble dressed up as a great meditation on the human condition and the inevitable planet that hits us all — death.
I’m sticking with dribble. So bring a lobster bib.
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8 thoughts on “A Strange Review: Melancholia”
Barry Arrington says:
Why let your mime punching be contingent on the unpredictable vagaries of the Academy? And why wait that long? Just find the nearest mime and punch him. You will be less melancholy.
I love nihilism. “Christianity is evil because it treats people like dirt. I will demonstrate my superiority by explaining how people are less than dirt.”
I saw it. The only interesting part was when they put those coat-hanger contraptions up to their chests to check on the size of the planet. I want one of those for Christmas.
Agreed. A clever visual device.
I’d like one that measures the approach of the Four Horsemen of the Apocalypse. When you can make out the stitching on the feedbags, you may want to rethink the purchase of that garden gnome…
vjmorton says:
“This could have been an intriguing look at clinical depression from the inside — you feel like the world is coming to an end and you just don’t care about anyone or anything and why won’t it all end already. … The finished product, however, is not that. It’s clinical depression as the only grown-up way of looking at life full stop. And the only reason I don’t kill myself if because you won’t all join in and thus confirm how smart I am.”
The two thoughts on either side of the ellipsis are not contradictory in the slightest. The latter is exactly what “a look at clinical depression from the inside” would be. Once one says he wants a view from the inside, then that view necessarily describes the film’s universe and one cannot complain that it takes that POV as normative. From the inside, suicide (the end of the world, subjectively speaking) IS rational and the only grown-up way, etc. Indeed, I said virtually all of this in the context of ANTICHRIST here — http://vjmorton.wordpress.com/2009/09/12/toronto-capsules-day-1/
I hear what you’re saying. I simply think Von Trier failed. He may have been striving for “Persona,” but he wound up with “The Big Bus” — a parody of an inner disaster movie.
U says:
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Shop » Scientific Journal » aqua 13(3-4) » aqua 13(3-4)_Paracheilinus nursalim
aqua 13(3-4)_Paracheilinus nursalim
Volume 13, Issue 3-4 – 25 January 2008
Gerald R. Allen and Mark V. Erdmann: Paracheilinus nursalim, a new species of flasher wrasse (Perciformes: Labridae) from the Bird’s Head Peninsula of western New Guinea with a key to the species of Paracheilinus, pp. 179-188
SKU: aqua 13-3-4_Paracheilinus nursalim Category: aqua 13(3-4)
Paracheilinus nursalim is described from 16 male specimens, 39.4-51.0 mm SL, and three females, 20.9-28.9 mm SL, collected at the Fak Fak Peninsula and Triton Bay area of western New Guinea. It is distinguished from all other members of the genus on the basis of coloration of adult males, particularly the presence of a pair of prominent blackish patches, one below the anterior dorsal fin and another covering the ventral half of the caudal peduncle. Males also possess unusually long caudal fin filaments, which extend for about 50% of the standard length in some individuals. The new species most closely resembles the sympatric P. cyaneus (northeast Kalimantan, Sulawesi, and western New Guinea), but is easily distinguished on the basis of the previously mentioned features as well as its predominately orange ground colour compared to the magenta or reddish coloration of P. cyaneus. The latter species further differs in having a dark triangular marking on the spinous dorsal fin, red dorsal and ventral margins on the caudal fin, which extend onto the filamentous lobes, and a blue band below the eye that is about twice the width of a similarly-positioned band in P. nursalim. A key is provided for distinguishing the 16 species of the genus.
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Editorial Charter for European Union Contract
I. Editorial Charter for European Union Contract
1. GENERAL PROVISION
The Contractor shall be independent of any instruction, pressure or request from any EU Institution, any EU Member State or any other State or Institution in all matters concerning the content of its “EU Services” as defined by the Contract.
Document Definitions:
All the Institutions of the European Union defined by the Treaties.
“EU Services”
The services and programmes on EU matters provided under this contract.
2. PROGRAMME CONTENT
2.1. Without prejudice to the generality of clause 4, the Contractor undertakes to provide and keep under review the EU Services with a view to the maintenance of high general standards in all respects (and in particular in respect of their content, quality and editorial integrity) and to their offering a wide range of topics (with regard both to the programmes as a whole and to the days of the week on which, and the times of the day at which, the programmes are broadcast), meeting the needs and interests of audiences, in accordance with the requirements specified in sub clause 2.2.
2.2. The requirements referred to in sub clause 2.1 are that EU Services:
Aim at selecting, checking and disseminating information about the EU;
Support and reflect EU cultural diversity;
Contain comprehensive, authoritative and impartial coverage of news and current affairs in the EU and throughout the world when having an EU dimension, as well as of informed debates at regional, national and EU levels;
Contain background and explanatory programmes;
Contain programmes which focus on the impact of EU policies, decisions and actions on the lives of EU citizens and reflect the concerns of both regional and national audiences
2.3. The Contractor shall present an impartial account prepared or commented by professional reporters of the proceedings of the European Parliament, the Council of Ministers of the EU, the European Councils, the European Commission or other EU Institutions and bodies.
3. OBJECTIVES FOR EU SERVICES
The Contractor shall:
3.1. Publish on its website and make available to anybody who require it an annual statement of promises to audiences describing its EU Services, standards and objectives;
3.2. Report in reasonable detail on the performance of the Contract in an annual report presented pursuant to the Contract as appropriate and, in particular, publish on its website an account of:
How the Contractor is meeting its published standards and objectives concerning the main programme services and types provided as part of EU Services;
The editorial standards appropriate to EU Services, the measures taken to ensure compliance with such standards and the extent to which the Contractor has complied with such standards;
The research and consultation undertaken during the year to ascertain the needs and interests of the audiences of EU Services, together with a summary of the main findings;
The subject matter and handling of complaints from such audiences indicating the proportion which was upheld.
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4.1. The Contractor shall do all it can to ensure that all programmes broadcast or transmitted by or on behalf of or under licence from the Contractor as part of EU Services:
Provide a properly balanced service consisting of a wide range of topics;
Are broadcast at the times provided for in the Contract or, if not provided for in the Contract, at appropriate times;
Treat controversial subjects with due accuracy and impartiality, both in the Contractor’s news services and in other more general programmes dealing with topics of public policy or of political or industrial controversy;
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Do not include any technical device which, by using images of very brief duration or by any other means, exploits the possibility of conveying a message to, or otherwise influencing the minds of, persons watching EU services without their being aware, or fully aware, of what has occurred.
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Draw up, and review at least once a year, a code giving guidance as to the rules to be observed in connection with the application of paragraph 4.1 in relation to its EU Services;
Do all that it can to ensure that the provisions of the code are observed in the provision of services and programmes (the Contractor may adopt different provisions in the code for different cases or circumstances).
4.3. The rules specified in the code referred to in sub clause 4.2 shall, in particular, take account that due impartiality should be preserved on the part of the Contractor as regards major matters falling within paragraph 4.1 as well as matters falling within that provision taken as a whole;
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What due impartiality does and does not require, either generally or in relation to particular circumstances;
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Those rules shall, in particular, indicate that due impartiality does not require absolute neutrality on every issue or detachment from fundamental democratic principles.
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7. EDITORIAL TRANSPARENCY REPORT 2018
euronews-transparency-report-2018.pdf
8. EU FRAMEWORK COMMITMENTS
As part of Euronews’ Framework agreement with the European Commission covering the period 2017-2021, Euronews is committed to
Progressively increasing and expanding the volume and impact of its reporting of EU affairs and policies
Improving the quality of reporting on EU affairs
Guaranteeing a European perspective in each of its language services
Improving digital coverage of European affairs as part of its wider multiplatform strategy
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Reinforcing the production and distribution of content in Euronews’ EU languages
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Exploring possibilities to broaden Euronews public service status, distribution activites and linguistic diversity within Europe
How this is achieved
Euronews fulfills the above missions using a range of approaches including:
Using correspondents and experienced freelancer journalists around Europe to report on the ground and bring different perspectives into coverage
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Adapting content for different platforms, according to European media consumption habits
Covering major events as they happen with live images and/or text commentary
Conducting interviews with news makers from across Europe and beyond
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Euronews wishes to show its viewers, on a daily basis, Europe as it is: richly diverse and complex.
Ambition and impartiality are the guiding principles that will shape the media’s coverage of current events in and outside the European Union.
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Our broadcasting formats - reports, interviews and debates - are designed to observe how the European Union’s actions, decisions and policies impact on its citizens’ lives.
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Euronews has been recognized a mission of European general interest in the field of information since 2010 by the European Commission.
To fully play its role as a transnational media organisation, Euronews must fulfil four European Missions to Inform: “News Brief”, “News Perspective”, “In Depth” and “Live”:
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The “News Perspective” Mission (EMI II) aims to give them the keys to understanding European current events.
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The “Live” Mission (EMI IV) aims to give them direct access, in real time, to the public debate and to the events that set the tempo of Europe’s institutions.
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The channel pays special attention to its independence when treating topics to do with public-interest, political and social issues, and more generally with all news themes subject to controversy. Programme content must be produced without any pressure from any EU institution, political party or business entity.
In general terms, the duty of independence dictates the conduct of all participants in the editorial production process, from the gathering of news through to its airing. Euronews journalists therefore undertake to “resist every pressure and (…) accept editorial orders only from the responsible persons of the editorial staff” (1971 Declaration of the Rights and Duties of Journalists).
Euronews remains impartial while carrying out its European Missions to Inform. Impartiality is defined essentially as the search to reasonably compare points of view within the bounds of fundamental democratic principles. This consequently enables the topic to be given a horizontal (for/against) or vertical(EU/national/regional) dialectic treatment.
The programmes made within the scope of the European Missions to Inform are produced with the constant care to promote cultural diversity, as defined by the Treaty (art. 151). They will aim, in particular, to improve viewers’ knowledge of the culture and history of Europe’s peoples.
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3. PROGRAMMING
To fulfil its four European Missions to Inform, Euronews has devised various Modules to fit better into its overall programme schedule. Below is an inventory describing their content (format, length and structure).
3.1 News modules
3.1.1 News mandatory & specifics
The production will be fed primarily by Euronews own newsgathering, driven by the enhanced production and journalistic capabilities, focusing more on our own original journalism, first-hand accounts, reactions and graphic elements, in order to decrease the use of news agencies.
Produced by specialist journalists, with content supplied by EbS but also footage from EBU member agencies or television channels, the Post-produced News packages give an update on a hot topic attracting public attention in Brussels or Strasbourg and in the member countries. The essential news about European institutions takes a central place in Euronews’ daily schedule, but is subject to increased editorial stringency compared to previous formats and to the general treatment of international news.
3.1.2 Live coverage
There is only one Module in this fourth and final European Mission to Inform: live broadcasts, with commentary and translation in seven languages, of the big events to do with the European Union and its institutions (European Parliament sessions, debates and votes; European Council meetings, press conferences, visits by heads of state and government, celebrations and commemorations, etc.). This direct access to the main events in European public life lets viewers make their own judgements about the decisions taken by the Union’s top bodies. These Live broadcasts may vary widely in length, depending on the event. On average, they will be 40' long. They will amount to a yearly total of 31 hours and 20 minutes.
3.1.3 European Correspondent Network
Euronews’ freelance network focused on putting the spotlight on European citizens and their challenges and achievements.
Our coverage included topics such as the Swedish elections, anti-corruption protests in Romania, the Catalunya crisis in Spain, the bridge collapse tragedy in Italy, the San Sebastian film festival in Spain as well as numerous other daily stories from Eastern Europe to the West of Europe.
Having original content, featuring the voices of those living through the stories we tell has had a positive impact on output. Stories from our freelance network perform on average more than four times better than other stories on our website.
Euronews brings the voices of Europeans from all corners of the continent into our overall focus on the wishes, choices and issues of Europeans at a crucial moment in its history with the elections of 2019 (see Improving News Coverage section).
3.2 Programs
3.2.1 The Brief from Brussels
The Brief from Brussels is a daily news segment complementing Euronews’ overall world news coverage, bringing Euronews’ daily European affairs coverage into a designated news spotlight.
Launched in 2016, The Brief from Brussels has quickly become a strong contribution to Euronews daily news coverage, by bringing a new impetus in our European Affairs coverage through content and presentation. The Brief from Brussels is an evening prime-time presence, included in the evening presented news bulletins on World and all languages, but still marking it as such with dedicated graphics.
Euronews’ European Affairs journalists in Brussels will produce a combination of daily “mandatory” stories as well as “multiplex” ones (several language journalists coming together to produce a common story, each bringing his/her own national ingredients into the pan-European mix), both on the live channel and the other languages channels.
Each journalist will present these stories on camera, targeting their own audiences as well as each journalist going into the field to cover their own content, which is the mixed together into a global output by the Brussels bureau. Euronews World will cover the selected topics in the live formats of this channel through a flexible variety of elements: voice-overs on videos and graphics and main soundbites.
3.2.2 State of the Union
Launched in 2016, The “State of the Union” quickly established itself as a flagship program in our European Affairs news reporting, through the comprehensive content selection and analysis.
The State of the Union is the weekly round-up of the main European political stories, focusing on the main evolutions of the elections campaign, the post-elections developments and the headline making events and their reverberations across Europe. The program is presented by a Euronews Brussels journalist, recorded and produced on Friday, and broadcast from Friday evening through the weekend until Sunday evening.
3.2.3 Insiders
Insiders was launch in April 2016 as a 20-minute weekly program of investigative reporting, focused on European issues with different perspectives. The aim is to tell the often unreported or under-reported stories of European citizens and the challenges they face -- be they economic, social or political.
Insiders is promoted digitally, not only on euronews.com but also with products especially designed for social media such as one-minute or less cut-downs of the show’s most poignant interviews and/or excerpts and short teasers for the program.
3.2.4 The Global Conversation
Conversations without filters, without digressions and without cuts.
This is the idea behind “Uncut - a special edition of the Global Conversation”, our unedited one-on-one interviews; a format we have successfully developed in 2018.
Uncut is an evolution of our flagship program The Global Conversation, where our leading journalists speak to high-profile guests about politics, business, culture and sport.
We will also keep developing the “All Views” strategy in the program, by inviting two or more guests offering different visions on an issue during some key episodes.
Uncut and Global Conversation are highly promoted on air and on our digital platforms. We regularly produce subtitled videos with the highlights of the show, along with articles and pictures that are highly share-able on the social platforms.
3.2.5 Magazines from different DGs of the European Commission
Over the past years, Euronews has consolidated a streamlined set of flagship programmes that present a pan-European perspective not only on the big stories of the day but on issues that affect Europeans that slip under the radar of other international media.
The ‘All Views’ message will remain at the heart of our magazines. Produced by journalists from across Europe, and with the mission to report from all corners of the continent and beyond, these magazines reflect the points of view, perspectives and opinions of as broad a cross section of Europeans as possible. This plurality of views remains a crucial mission statement for Euronews.
We continue to emphasize and innovate our current affairs output and enrich the content of programmes produced in partnership with the DGs. We see these programmes as a contribution to the dialogue and debate in the European public sphere, but also – reflecting the changing times we live in – juxtaposing, comparing and analyzing the national perspectives that reflect the enormous diversity of cultures and values across the Union.
The programmes co-funded by the DGs of the European Commission include:
- Aid Zone
- Business Planet
- Futuris
- Ocean
- Real Economy
- Smart Regions
3.3 Quantity per module
Besides the qualitative undertakings made above, Euronews also gives its viewers guarantees on how many units of each module will be broadcast yearly. Each European Mission to Inform thus has a clearly stated presence in the Euronews grid and programming.
Nb episodes per year
Post produced news stories 1300
Specific post produced news stories 340
The Brief from Brussels 150
State of The Union 47
Insiders 10
Global Conversation – short format 18
Global Conversation – Long format 8
Freelance Network -
ANNUAL QUANTITIES BY MISSION AND MODULE
Mission I - 1,227 News Brief packages
Module 01: 141 Filmed News packages
Module 02: 1,086 Post-produced News packages
Mission II - 198 News Perspective packages
Module 03: 104 Post-produced Weekly News packages
Module 04: 26 Filmed Daily News packages
Module 05: 68 Post-produced Daily News packages
200 News In Depth packages
Module 06: 47 Portraits and Interviews
Module 07: 12 Debates
Module 08: 47 Filmed 8' Features
Module 09: 47 Post-produced 8' Features
Module 10: 47 European Reviews
Mission IV - 24 Lives
Module 11: 720 minutes of European live broadcasts, i.e. approx. 24 × 30 minutes
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Policy —
Senate bill gives feds power to order piracy site blacklisting
Senate anti-piracy legislation introduced Thursday would dramatically increase …
David Kravets, wired.com - May 12, 2011 10:37 pm UTC
with 85 posters participating
Senate anti-piracy legislation introduced Thursday would dramatically increase the government’s legal power to disrupt and shutter websites “dedicated to infringing activities.”
A major feature of the PROTECT IP Act, introduced by 11 senators of all stripes, would grant the government the authority to bring lawsuits against these websites, and obtain court orders requiring search engines like Google to stop displaying links to them.
“Both law enforcement and rights holders are currently limited in the remedies available to combat websites dedicated to offering infringing content and products,” said Senator Patrick Leahy, a Vermont Democrat and the bill’s main sponsor.
The proposal is an offshoot to the Combating Online Infringement and Counterfeits Act introduced last year. It was scrapped by its authors in exchange for the PROTECT IP Act in a bid to win Senate passage.
Under the old COICA draft, the government was authorized to obtain court orders to seize so-called generic top-level domains ending in .com, .org and .net The new legislation (PDF), with the same sponsors, narrows that somewhat. Instead of allowing for the seizure of domains, it allows the Justice Department to obtain court orders demanding American ISPs to stop rendering the DNS for a particular website—meaning the sites would still be accessible outside the United States.
Either way, though, the legislation amounts to the Holy Grail of intellectual-property enforcement that the recording industry, movie studios and their union and guild workforces have been clamoring for since the George W. Bush administration.
“As the guilds and unions that represent 400,000 creators, performers and craftspeople who create the multitude of diverse films, television programs and sound recordings that are enjoyed by billions of people around the world, we unequivocally support this bill which, by providing protection for our members’ work, clearly shows that our government will not condone or permit the wholesale looting of the American economy and American creativity and ingenuity—regardless of how that looting is disguised on the internet to fool the American consumer,” (PDF) a host of unions said Wednesday, including the American Federation of Musicians, American Federation of Television and Radio Artists and, among others, the Directors Guild of America.
The new bill also gives content owners more rights than the old bill. It would allow rights holders to seek court orders instructing online ad services and credit card companies from partnering with the infringing sites—a power the government is granted from either legislative version.
Only the government gets the DNS blocking powers. And the Digital Millennium Copyright Act already grants rights holders the ability to demand search engines to stop displaying search results to infringing sites.
Despite the new bill watering down the United States’ reach, the government has been invoking an asset-forfeiture law to seize generic, top-level domains of infringing websites under a program called Operation in Our Sites.” It began last year and the Department of Homeland Security has targeted 120 sites.
Abigail Phillips, a copyright attorney at the Electronic Frontier Foundation, said because of Operation in Our Sites, the DNS changeover “doesn’t seem all that meaningful.”
Sherwin Siy, deputy legal director at Public Knowledge, noted that the measure does not narrowly define the websites that could be targeted.
“The bill still defines a site as ‘dedicated to infringing activities’ if it is designed or marketed as ‘enabling or facilitating’ actions that are found to be infringing,” he said. “In other words, even if the site isn’t itself infringing copyright, if its actions ‘enable or facilitate’ someone else’s infringement, the government can tell ISPs to blacklist your site, and copyright holders can sue to cut your funding.”
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Down-regulating peroxisome proliferator-activated receptor-gamma coactivator-1beta alleviates the proinflammatory effect of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting extracellular signal-regulated kinase, p38 and nuclear factor-kappaB activation
Jing-Jing Zhou1,
Jian-Da Ma1,
Ying-Qian Mo1,
Dong-Hui Zheng1,
Le-Feng Chen1,
Xiu-Ning Wei1 &
Lie Dai1
Arthritis Research & Therapy volume 16, Article number: 472 (2014) Cite this article
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction and disability. Peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1β) is a transcriptional coactivator that plays important roles in regulating multiple aspects of energy metabolism and cytokine signaling pathways. PGC-1β overexpression leads to the attenuation of macrophage-mediated inflammation. In this study, we aimed to determine the expression of PGC-1β in RA synovium and fibroblast-like synoviocytes (FLS), and explore the mechanisms of PGC-1β on both the proinflammatory effects and apoptosis in RA-FLS.
Synovium was obtained from 31 patients with active RA, as well as 13 osteoarthritis (OA) and 10 orthopedic arthropathies (Orth.A) as "less inflamed" disease controls. FLS were then isolated and cultured. Synovial PGC-1β expression was determined by immunohistochemistry staining, while FLS PGC-1β expression was detected by immunofluorescence staining, quantitative real-time PCR (qPCR) assay and western blot. PGC-1β was depleted by lentivirus sh-RNA, and up-regulated by pcDNA3.1- PGC-1β. The expression of proinflammatory cytokines, matrix metalloproteinases and receptor activator of nuclear factor-kappaB ligand was analyzed by qPCR, cytometric bead array and western blot. The expression of mitogen-activated protein kinases and nuclear factor-kappaB (NF-κB) was determined by qPCR and western blot. Besides, cell apoptosis was examined using flow cytometry. The interaction between PGC-1β and NF-κB was performed by dual-luciferase reporter gene assays.
(A) Synovial PGC-1β was over-expressed in RA patients compared with OA or Orth.A patients. (B) PGC-1β expression significantly increased in RA-FLS compared with OA-FLS. (C) PGC-1β mediated the expression of proinflammatory cytokines and apoptosis through extracellular signal-regulated kinase (ERK), p38 and NF-κB in RA-FLS. (D) PGC-1β mediated NF-κB transcription in RA-FLS, but did not affect ERK and p38.
The results indicate that PGC-1β may play important roles in the proinflammatory effects and apoptosis of RA-FLS.
Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by chronic inflammatory synovitis, leading to invasion of synovial tissue into the adjacent cartilage matrix with degradation of articular cartilage and bone [1]. RA affects 0.5% to 1.0% of the population worldwide [2]. During the last few decades, treatment options have diversified and the availability and selection of different treatments for individual patients has greatly improved. Despite these advances, a cure for RA is not yet available. Therefore, the precise etiology and underlying mechanisms of the condition require further elucidation.
Fibroblast-like synoviocytes (FLS) are recognized as a prominent joint-specific determinant of RA because of their hyperproliferative properties and hyperproduction of both proinflammatory cytokines that perpetuate inflammation and matrix metalloproteinases (MMPs) that contribute to cartilage destruction [3],[4]. Briefly, proinflammatory cytokines such as TNF-α and IL-1β strongly initiate FLS, and consistently enhance and potentially stabilize the activated phenotype of FLS [5]. The activation of FLS can produce TNF-α, IL-1β and IL-6, all of which are involved in sustaining regulatory feedback loops and inducing production of MMPs, cathepsins and aggrecanases [6]. Activated FLS can also produce IL-8, which is implicated in leukocyte recruitment to diseased synovium [7]. FLS govern the differentiation of macrophages into osteoclasts through upregulation of receptor activator of nuclear factor kappa-B ligand (RANKL) [8]. This phenomenon is coordinated with cellular mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-κB) signaling pathways being stimulated. These feedback loops are regarded as significant regulators of proinflammatory cytokines in RA [9],[10]. As FLS are key effectors in the pathogenesis of RA, recent approaches for RA treatment have focused on the inhibition of its function and induction of cell death, including the modulation of activities of various nuclear transcriptional factors relevant to the inflammatory process [11]-[13].
Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) is a transcriptional coactivator that plays important roles in regulating multiple aspects of energy metabolism and cytokine signaling pathways through interaction with many transcription factors [14],[15]. The first member of the PGC-1 family is now termed PGC-1α, while PGC-1β is the closest homolog of PGC-1α and shares extensive sequence identity [15],[16]. Emerging evidence suggests that PGC-1 plays important roles in regulating inflammation. PGC-1 can visibly suppress proinflammatory effects by inhibiting the activation of NF-κB in skeletal muscle cells [17]. PGC-1β has been demonstrated to be capable of regulating inflammation by suppressing the expression of TNF-α, IL-6, IL-8 and IL-1β mRNA levels in human skeletal muscle [18]. Overexpression of PGC-1α decreased both basal and platelet-derived growth factor-induced p38 MAPK phosphorylation [19]. More importantly, increased expression of PGC-1β resulted in the attenuation of macrophage-mediated inflammation [20]. PGC-1β is therefore a critical mediator in regulating proinflammatory cytokines. However, until now, whether PGC-1β participates in the pathophysiological development of RA has been poorly understood. This study aimed to determine the expression of PGC-1β in RA synovium and FLS, and explore the mechanisms of PGC-1β on both the proinflammatory effects and apoptosis in RA-FLS.
Methods and materials
Thirty-one Chinese patients with RA who fulfilled the 1987 revised criteria of the American College of Rheumatology (ACR) [21] or 2010 ACR/European League against Rheumatism (EULAR) classification criteria for RA [22] were included from the Department of Rheumatology of Sun Yat-sen Memorial Hospital. All patients had active disease, defined as a 28-joint disease activity score (DAS28) ≥2.6. Thirteen patients with osteoarthritis (OA) and ten with non-inflammatory orthopedic arthropathies (Orth.A), including five with meniscus injury, two with anterior cruciate ligament injuries, one with traumatic arthritis, one with medial plica syndrome, one with discoid meniscus, were included from the Department of Rheumatology and Orthopedics as less-inflamed disease controls [23]. Baseline demographic and clinical features of all patients are shown in Table 1. This study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by Medical Ethics Committee of Sun Yat-sen Memorial Hospital. All patients gave written informed consent.
Table 1 Baseline demographic and clinical features of RA, OA and Orth.A patients in the study of synovial PGC-1β by immunohistochemistry
Clinical assessments
Clinical data of all patients with RA were collected at baseline, including the 28-joint tender and swollen joint count (28TJC and 28SJC), patient and provider global assessment of disease activity (PtGA and PrGA), pain visual analog scale (pain VAS), Chinese language version of Stanford health assessment questionnaire (HAQ) [24], erythrocyte sedimentation rate (ESR), C-reactive protein (CRP); rheumatoid factor (RF), and anti-cyclic citrullinated peptide antibody (anti-CCP). Disease activity was assessed with DAS28 with four variables, including CRP (DAS28 (4)-CRP) [25].
Synovial tissue collection and FLS culture
RA synovium was collected by closed needle biopsy [26]. At least six pieces of synovial tissue were obtained per patient to minimize sampling error [27]. The OA and Orth.A specimens were obtained from knees by closed needle biopsy, arthroplasty or arthroscopy. All samples were fixed in 10% neutral formalin and embedded in paraffin. Sections (5 μm) were cut serially and mounted on adhesive glass slides. Sealed slides were stored at -20°C until staining.
FLS were isolated from the synovial tissues by modified tissue culture method [28]. Fresh synovial tissues were minced and digested in type I collagenase (Sigma-Aldrich, St Louis, MO, USA). The cells were cultured with DMEM-Ham's F-12 (DMEM/F12) (Gibco, Life Technologies, Shanghai, China), containing 20% fetal calf serum (Gibco, Life Technologies, Mulgrave, VIC, Australia) in a humidified 5% CO2 incubator. FLS from passages three to five were used in this study.
Serial sections of synovial tissues were stained with H&E and a three-step immunoperoxidase method for immunohistochemistry. Sections were incubated with the PGC-1β (Bioss, Beijing, China) at 1/200 dilution overnight at 4°C after deparaffinization and retrieval. The sections were incubated with EnVision Mouse or Rabbit conjugate (Dako, Carpinteria, USA) for 30 minutes at 37°C. The 3,3-diaminobenzidine (DAB)-positive substrate was used for the color reaction. Sections were counterstained with hematoxylin. Nonspecific isotype IgG was used as a negative control. The percentage of PGC-1β-positive-staining cells in the lining layers and sublining area were determined by manual observation of five different fields at magnification × 400, respectively.
FLS were incubated with primary antibody recognizing PGC-1β (Bioss, Beijing, China) or normal rabbit IgG (control) after fixation, permeablization and blocking. FLS were stained with Alexa Fluor 488-conjugated goat anti-mouse IgG diluted 1:1,000 (Invitrogen, Carlsbad, USA), and co-stained with 4'6-diamindino-2-phenylindole (DAPI) (Sigma-Aldrich, St Louis, MO, USA) to visualize nuclei. FLS were analyzed by confocal microscopy (Zeiss, Jena, Germany).
Lentivirus infection in RA-FLS
Gene knockdown was performed using lentivirus sh-RNA, which was synthesized by Shanghai GeneChem Co Ltd (Shanghai, China). Short hairpin RNA (shRNA) were cloned into pLKO.1 (GV248) lentiviral vectors. The sh-PGC-1β targeting sequence was CAGATACACTGACTACGAT. Culture supernatants containing sh-RNA were added to RA-FLS in the presence of polybrene. The cells were selected using 1 μg/ml puromycin after 24 h. Stable cell lines were verified by western blot.
Plasmid construction and transfection
The fragment of human PGC-1β was amplified from the cDNA of 293T cells by using specific primers (forward primer 5'-TTCAAGCTTATGGCGGGGAACGACTG-3' and reverse primer 5'-ATCTCGAGTCAATGCAGGCTCTGCTG-3') with the HindIII and XhoI restriction sites. Following the conditions at 35 cycles at 94°C for 1 minute, 58°C for 180 s, and 72°C for 1 minute, their action was continued for 10 minutes at 72°C after the last cycle using Ex Taq Polymerase (Takara, Otsu, Japan). The PCR product was purified and digested with HindIIIand Xho, then cloned into a mammalian expression vector pcDNA3.1 (+) with the corresponding restriction sites (Novagen, Darmstad, Germany). The recombinant plasmid was confirmed by DNA sequencing. RA-FLS were cultured in 6-well cell culture plates to 80 to 90% confluency and then subjected to transfection using the lipofectamine TM 2000 reagent (Life Technologies, Carlsbad, USA) according to the manufacturer's instructions. Cells were harvested 72 h after transfection.
Apoptosis detection assay and cell cycle analysis
The apoptosis of stably transduced RA-FLS was measured through detecting APC-conjugated Annexin-V and 7-AAD by flow cytometry (FCM) (BD PharMingen, San Diego, USA). For cell cycle analysis, they were fixed with cold ethanol overnight and then treated with propidium iodide and RNase before fluorescence-activated cell sorting (FACS) analysis. The cell cycle distribution was determined using flow cytometry (FCM). Apoptosis and cell cycle were quantified using FACS and CellQuest software (BD Biosciences, Mountain View, USA).
Quantitative real-time PCR (qPCR)
Total RNA was prepared from cells using RNAiso Reagent (Takara, Otsu, Japan). Complementary DNA (cDNA) samples were synthesized with reverse-transcription kit (Takara, Otsu, Japan). Amplification of the cDNA was performed using specific oligonucleotide primers (Table 2). The qPCR was performed using QuantiTeckTM SYBR Green PCR kit (Takara, Otsu, Japan). The reactions were initiated with denaturation of cDNA templates at 95°C for 30 s, 95°C for 5 s and 60°C for 30 s and amplification for 40 to 50 cycles. Samples were run in triplicate in a Roche LightCycler480 sequence detector system (Roche, Basel, Switzerland).
Table 2 Primers for quantitative real-time PCR
Protein lysates from cells were subjected to SDS-PAGE and target proteins were detected with primary antibodies recognizing p-p38, p38, P-extracellular signal-regulated kinase (P-ERK), ERK, p-JNK, JNK, p-NF-κB p65 (Ser536), NF-κβ p65 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (CST, Danvers, Massachusetts, USA), PGC-1β and RANKL (Epitomics, San Francisco, USA), MMP-3 and MMP-13 (Abcam, Cambridge, USA) respectively. After incubation with appropriate horseradish peroxidase (HRP)-conjugated secondary antibodies (EarthOx, Millbrae, California, USA), protein bands were visualized using enhanced chemiluminescence (Millipore, Boston, USA) plus western blot detection reagents followed by exposure to a scanning imager (G:BOX Gel & Blot Imaging Series from Syngene, Cambridge, UK).
Determination of proinflammatory cytokine levels
Proinflammatory cytokines including IL-8, IL-6, IL-1β, and TNF-α in the culture supernatants were quantified using cytometric bead array (CBA) human inflammatory cytokines kit (BD Biosciences, San Jose, USA). The cytokines were analyzed by standard curves plotted using a four-parameter logistic curve-fitting model.
Dual-luciferase reporter gene assays
Luciferase reporter construct containing the NF-κB promoter region (wild type, WT) or a construct with mutated sites (MUT) was cloned into pGL3-based vectors, then temporarily transfected with 1 μg of the promoter reporter plasmid into RA-FLS using the Lipofectamine 2000 (Invitrogen, Shanghai, China), while 40 ng of the phRL-TK plasmid were co-transfected into the cells to verify transfection efficiency. Then, RA-FLS cells were co-transfected with pcDNA3.1-PGC-1β to increase PGC-1β expression, and empty vector pcDNA3.1 to keep total DNA concentration constant. After 36 h of transfection, the luciferase activities were measured on a spectraMax M5 reader (Molecular Devices, California, USA) using the Dual-Luciferase Reporter Assay System (Promega, Madison, USA).
Statistical analyses were performed with SPSS 13.0 statistical software (SPSS Inc., Chicago, IL, USA). For categorical variables, data were presented as frequencies and percentages. For continuous variables, data were presented as mean and SD, or median and IQR. Nonparametric tests (Mann-Whitney rank-sum test between two groups, Kruskal-Wallis one-way analysis of variance on ranks among three or more groups for continuous variables) were used to compare the differences in PGC-1β expression in synovium and FLS. Spearman's rank order correlation test was used for assessing the correlation between PGC1-1β expression in RA-FLS and both clinical indicators and proinflammatory cytokines. Student's t-test was used to assess the differences in proinflammatory cytokines, MMPs and RANKL between the experimental and control groups. Two tailed P-values <0.05 were considered statistically significant.
Characteristics of the study patients
Baseline demographic and clinical features of all patients are shown in Table 1. Age and sex did not differ among the patients with RA and OA. Among the patients with RA, 45% (14/31) had never taken corticosteroids or disease-modifying anti-rheumatic drugs (DMARDs). These patients had taken only Chinese herbal medicine and/or painkillers to relieve arthralgia. At recruitment, 13% (4/31) had taken corticosteroids alone. The remaining 42% (13/31) received treatment with one or more DMARDs, including methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, or etanercept.
Expression of PGC-1β is upregulated in synovium in RA
PGC-1β expression in RA synovium was observed with intense nuclear staining in lining cells (both macrophage-like synoviocytes and fibroblast-like synoviocytes) and sublining inflammatory cells (mostly in lymphocytes and plasma cells). As shown in Figure 1, the percentage of PGC-1β + lining cells (median 87%, IQR 78% to 91%) was significantly higher than that in OA (median 69%, IQR 47% to 81%) or in Orth.A (median 63%, IQR 48% to 69%). In the sublining area, the percentage of PGC-1β + lining cells (median 90%, IQR 86% to 93%) was significantly higher than that in OA (median 71%, IQR 60% to 86%) or in Orth.A (median 60%, IQR 50% to 78%).
Expression of peroxisome proliferator-activated receptor-gamma coactivator-1 β (PGC-1β) is upregulated in synovium in rheumatoid arthritis (RA). (A) Intensive synovial PGC-1β expression in synovium of a RA patient. (B) Moderate synovial PGC-1β expression in synovium of an osteoarthritis (OA) patient. (C) Mild synovial PGC-1β expression in synovium of an orthopedic arthropathy (Orth.A) patient. (D) Percentage of lining PGC-1β + cells in RA, OA and Orth.A patients. A, B, C: original magnification × 400. The data are represented by median ± IQR. **P <0.01, ***P <0.001.
PGC-1β is over-expressed in RA-FLS
The expression of PGC-1β mRNA and protein in RA-FLS was detected from eight RA patients and six OA patients. Their baseline demographic and clinical features are shown in Table 3. Immunofluorescence staining showed higher expression of PGC-1β in RA-FLS compared with OA-FLS (Figure 2A). The expression of PGC-1β mRNA and protein in RA-FLS was significantly enhanced compared with OA controls (3.18 ± 1.72 versus 1.17 ± 0.74, P = 0.019; 0.33 ± 0.17 versus 0.11 ± 0.08, P = 0.014, respectively) (Figure 2B).
Table 3 Baseline demographic and clinical features of RA and OA patients in the study of PGC-1β expression in FLS by qPCR and western blot
Expression of peroxisome proliferator-activated receptor-gamma coactivator-1 β (PGC-1β) is over-expressed in rheumatoid arthritis (RA)-fibrolast-like synoviocytes (FLS). (A) Immunofluorescence staining of PGC-1β in primary cultures of FLS from osteoarthritis (OA) and RA patients. (a, DAPI (blue); b, PGC-1β (green); c, neutral light; d, merged a, b with c. a, b, c: original magnification × 400). (B) Left panel: PGC-1β mRNA expression in FLS from RA (n = 8) compared with that from OA (n =6) evaluated by qPCR. Right panel: PGC-1β protein level in FLS from RA patients (n = 8) and OA controls (n = 6) was detected by western blot. The intensity for each band was densitometrically quantified and normalized against the intensity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The data are represented by mean ± SD. *P <0.05.
RA-FLS PGC-1β protein expression shows positive correlation with clinical parameters
Moreover, significant correlations were found between FLS PGC-1β expression and CRP, ESR or DAS28 from eight RA patients (CRP: r = 0.738, P = 0.037; ESR: r = 0.762, P = 0.028; DAS28: r = 0.786, P = 0.021). There was no significant correlation between PGC-1β expression and RF, anti-CCP, 28TJC, 28SJC, PtGA, PrGA, pain VAS or HAQ (all P >0.05).
PGC-1β knockdown attenuates proinflammatory cytokines, MMPs and RANKL production in RA-FLS
To determine the role of PGC-1β in RA-FLS proinflammatory cytokine production, the proinflammation production in PGC-1β knockdown RA-FLS was compared with negative control (NC) infected with sh-GFP. The protein expression of PGC-1β in RA-FLS transfected with sh-PGC-1β was hardly detected compared with NC (Figure 3A). PGC-1β knockdown suppressed the expression of TNF-α, IL-6, IL-8, RANKL, MMP-3 and MMP-13 relative to the NC, but not IL-1β (Figure 3B and 3C). To explore whether this effect is mediated through inhibition of the MAPK and NF-κB signaling pathway, MAPK and NF-κB expression were evaluated. From these results, decreased expression of PGC-1β visibly suppressed the activity of ERK, p38 and NF-κB, but not JNK (Figure 3A).
Peroxisome proliferator-activated receptor-gamma coactivator-1 β (PGC-1β) knockdown attenuates proinflammatory cytokines, matrix metalloproteinases (MMPs) and receptor activator of nuclear factor-kappa B ligand (RANKL) production in rheumatoid arthritis (RA)-fibrolast-like synoviocytes (FLS). (A) After PGC-1β knockdown, the protein level of mitogen-activated protein kinases (MAPKs) in FLS was detected by western blot. (B) After PGC-1β knockdown, the proinflammatory cytokines, MMPs and RANKL mRNA expression in FLS was evaluated by qPCR. (C) After PGC-1β knockdown, the protein level of proinflammatory cytokines was examined by cytometric bead array, while the level of MMP-3, MMP-13 and RANKL was detected by western blot. The data are represented by mean ± SD from three independent experiments. *P <0.05, **P <0.01, ***P <0.001.
PGC-1β overexpression enhances proinflammatory cytokines, MMPs and RANKL production in RA-FLS
To determine whether PGC-1β overexpression enhanced proinflammatory cytokines production, RA-FLS were transfected with pcDNA3.1-PGC-1β or pcDNA3.1control. As shown in Figure 4A, PGC-1β protein expression was significantly overexpressed in RA-FLS transfected with pcDNA3.1-PGC-1β compared with cells transfected with pcDNA3.1 control. PGC-1β overexpression remarkably exacerbated RA-FLS-mediated inflammation, as evidenced by upregulating TNF-α, IL-6, IL-8, RANKL, MMP-3 and MMP-13 expression, but not IL-1β (Figure 4B and 4C). A detailed analysis of downstream signaling pathways was performed to detect the levels of phosphorylated MAPKs and NF-κB. The levels of ERK, p38 and NF-κB phosphorylation increased after PGC-1β overexpression in RA-FLS (Figure 4A).
Peroxisome proliferator-activated receptor-gamma coactivator-1 β (PGC-1β) overexpression enhances proinflammatory cytokines, matrix metalloproteinases (MMPs) and receptor activator of nuclear factor-kappa B ligand (RANKL) production in rheumatoid arthritis (RA)-fibrolast-like synoviocytes (FLS). (A) After PGC-1β overexpression, the protein level of mitogen-activated protein kinases (MAPKs) in FLS was detected by western blot. (B) After PGC-1β overexpression, the proinflammatory cytokines, MMPs and RANKL mRNA expression in FLS was evaluated by qPCR. (C) After PGC-1β overexpression, the protein level of proinflammatory cytokines was examined by cytometric bead array, while the level of MMP-3, MMP-13 and RANKL was detected by western blot. The data are represented by mean ± SD from three independent experiments. *P < 0.05, **P <0.01, ***P <0.001.
PGC-1β knockdown enhances apoptosis in RA-FLS
The results of Annexin V APC-A and PI FCM analyses showed that lentivirus-mediated inhibition of PGC-1β significantly increased early apoptosis and total apoptosis except late apoptosis relative to the NC (early apoptosis: 7.15 ± 0.10 versus 20 ± 12.11, P = 0.026; late apoptosis: 2.85 ± 2.10 versus 5.64 ± 6.69, P = 0.110; total apoptosis: 10 ± 2.20 versus 25.30 ± 18.67, P = 0.026) in RA-FLS (Figure 5A). To assess whether this effect was mediated through perturbation of the cell cycle, cellular subpopulations at various phases of the cell cycle were analyzed. The results showed no significant change at different phases relative to the NC (Figure 5B).
Peroxisome proliferator-activated receptor-gamma coactivator-1 β (PGC-1β) knockdown enhances apoptosis in rheumatoid arthritis (RA)-fibrolast-like synoviocytes (FLS). (A). Flow cytometric analysis demonstrating the effect of PGC-1β knockdown on cell apoptosis. (B) Flow cytometric analysis demonstrating the effect of PGC-1β knockdown on cell cycle progression. The data are represented by mean ± SD from three independent experiments. *P <0.05.
PGC-1β promotes NF-κB transcription in RA-FLS
To assess whether PGC-1β indirectly or directly mediates ERK, p38 and NF-κB transcription, the mRNA expression of ERK, p38 and NF-κB in PGC-1β knockdown RA-FLS were compared with NC infected with sh-GFP. Knockdown of PGC-1β significantly suppressed mRNA expression of NF-κB except ERK and p38 (Figure 6A), which suggests that PGC-1β may directly mediate NF-κB transcription.
Peroxisome proliferator-activated receptor-gamma coactivator-1 β (PGC-1β) promotes NF-κB transcription in rheumatoid arthritis (RA)-fibrolast-like synoviocytes (FLS). (A). After PGC-1β overexpression, the mRNA expression of ERK, p38 and NF-κB in FLS was evaluated by qPCR. (B) After RA-FLS transfected with a wild type-NF-κB reporter region (WT) and plasmid pcDNA3.1-PGC-1β or pcDNA3.1, the luciferase activities were measured on a spectraMax M5 reader. (C) After RA-FLS transfected with plasmid pcDNA3.1-PGC-1β and WT region or a mutated-NF-κB reporter construct (MUT), the luciferase activities were measured on a spectraMax M5 reader. The data are represented by mean ± SD from three independent experiments. **P <0.01, ***P <0.001.
To experimentally validate whether PGC-1β mediated NF-κB transcription, reporter gene assays were performed. Co-transfection of pcDNA3.1-PGC-1β resulted in an increase in NF-κB luciferase activity compared with co-transfection of pcDNA3.1 (Figure 6B). PGC-1β progressively increased NF-κB luciferase activity in WT more than in MUT (Figure 6C). These results suggest that PGC-1β directly promoted NF-κB transcription.
RA is an autoimmune systemic inflammatory disease that causes progressive synovial inflammation resulting in irreversible joint destruction, chronic disability and premature mortality [10]. RA-FLS are key mediators of cartilage and bone destruction. Activated RA-FLS play crucial roles in determining the site where inflammation occurs and in the subsequent maintenance of persistent inflammation in the joint microenvironment [29]. They act directly on cartilage through secretion of MMPs, cathepsins and inflammatory cytokines, and indirectly on bone by regulating osteoclastogenesis [30],[31]. Therefore, inhibition of proinflammatory cytokine, MMP and RANKL production in RA-FLS constitutes an important target for novel therapeutic approaches that hinder the destruction of cartilage and bone [32]. It has been demonstrated that NF-κB and MAPK are central regulators in inflammatory processes, including the pathophysiological development of RA [33],[34]. Activation of NF-κB and MAPKs robustly induce proinflammatory cytokines, MMPs and RANKL production in RA-FLS [32],[35].
PGC-1β is a transcriptional coactivator that regulates diverse signal transduction pathways [16], and has been reported to exert protective effects through inhibition of NF-κB activity [17]. PGC-1α overexpression vigorously has been shown to inhibit p38 MAPK phosphorylation [19]. It remains unknown as to whether PGC-1β plays a role in the regulation of RA-FLS inflammation. To the best of our knowledge, this is the first study investigating the effects of PGC-1β on inflammation in RA. In the present study, we found that PGC-1β was expressed in lining cells (both macrophage-like synoviocytes and fibroblast-like synoviocytes) and sublining inflammatory cells (mostly in lymphocytes and plasma cells), and PGC-1β expression in RA synovium was significantly higher than that in OA or Orth.A synovium. Consistently, PGC-1β expression was more notably upregulated in RA-FLS than in OA-FLS. We also observed significant positive correlation of RA-FLS PGC-1β expression with clinical parameters of disease activity, including DAS28, CRP and ESR. Thus, we postulate that elevated PGC-1β expression may be potentially involved in the pathogenesis of inflammation in RA.
To further explore the effect of PGC-1β on RA-FLS-mediated inflammation, we used lentivirus sh-RNA to inhibit PGC-1β expression and pcDNA3.1-PGC-1β to enhance PGC-1β expression. The results showed that the expression of TNF-α, IL-6, IL-8, MMP-3, MMP-13 and RANKL, and the activity of ERK, p38 and NF-κB, were clearly restrained in PGC-1β knockdown RA-FLS. Conversely, the expression of TNF-α, IL-6, IL-8, MMP-3, MMP-13 and RANKL, and the activity of ERK, p38 and NF-κB were visibly increased in PGC-1β overexpression RA-FLS. Several lines of evidence have demonstrated that inhibition of ERK, p38 and NF-κB activation dampened TNF-α, IL-6, IL-8, MMP-3, MMP-13 and RNAKL expression in RA-FLS [35]-[38]. We therefore hypothesized that PGC-1β mediated the expression of TNF-α, IL-6, IL-8, MMP-3, MMP-13 and RANKL through ERK, p38 and NF-κB. This is further substantiated by a study that TNF-α expression was lower in muscle-specific PGC-1α knockout mice, and TNF-α expression increased in muscle-specific PGC-1α overexpression mice compared with littermate WT mice [39]. Contrary to that study, it was reported that PGC-1β overexpression resulted in the attenuation of macrophage-mediated inflammation by strongly inhibiting proinflammatory cytokine production [20]. The role of PGC-1β appears very diverse and the proinflammatory or anti-inflammatory effects of PGC-1β in different disease models require further study.
In our study, we found that PGC-1β mediated proinflammatory cytokine production without IL-1β, but the specific mechanism remains unclear. Recently, Promsong et al. reported that ellagic acid resulted in an increase of IL-1β and a decrease of IL-6, IL-8 and TNF-α in oral epithelial cells [40]. In addition, the wild Legionella pneumophila strain has been shown to increase the levels of IL-8, IL-6, and TNF-α but not IL-1β in human pulmonary carcinoma cells [41]. Therefore, self-regulation of PGC-1β-mediated IL-6, IL-8 and TNF-α expression, but not IL-1β, might be attributed to the difference in existing pathways regulating IL-1β, IL-6, IL-8 and TNF-α production.
It has been established that defective apoptosis contributes to synovial hyperplasia in RA. Promoting RA-FLS apoptosis is a new treatment strategy for RA [42]. In the present study, we found increased early apoptosis and total apoptosis in PGC-1β knockdown RA-FLS. However, the cell cycle showed no significant change after PGC-1β suppression, which may imply that PGC-1β affects RA-FLS apoptosis through a molecular mechanism other than the cell cycle. Previous research has indicated that ERK, p38 and NF-κB negatively regulates RA-FLS apoptosis [43]-[46]. We postulated that suppression of PGC-1β might promote RA-FLS apoptosis through inhibition of ERK, p38 and NF-κB activation.
Our results also showed that PGC-1β downregulation significantly inhibited the mRNA expression of NF-κB, except for ERK and p38, which indicates that PGC-1β might mediate NF-κB transcription. To further validate PGC-1β-mediated NF-κB transcription, we performed reporter gene assays. The assays showed that PGC-1β overexpression resulted in increased NF-κB luciferase activity, which indicated that PGC-1β directly promoted NF-κB transcription. The result was consistent with a previous study showing that PGC-1 downregulation decreases NF-κB transcription [47]. The precise mechanism for the interaction between PGC-1β and ERK or p38 remains unclear and requires further study.
The results of this study show that suppression of PGC-1β attenuates the expression of TNF-α, IL-6, IL-8, MMP-3, MMP-13 and RANKL, and enhances apoptosis through inhibition of p38, ERK and NF-κB activation in RA-FLS, which suggests that blocking PGC-1β expression may provide a novel target for the treatment of RA.
28SJC:
28-joint swollen-joint count
28TJC:
28-joint tender-joint count
anti-CCP:
anti-cyclic citrullinated peptide antibody
CBA:
cytometric bead array
CRP:
DAPI:
4'6-diamindino-2-phenylindole
DAS28:
disease activity score 28-joint assessment
DAS28 (4)-CRP:
28-joint disease activity score with four variables, including C-reactive protein
DMARD:
disease-modifying anti-rheumatic drug
DMEM/F12:
Dulbecco's modified Eagle's medium (DMEM)-Ham's F-12
ERK:
extracellular signal-regulated kinase
erythrocyte sedimentation rate
FACS:
fluorescence-activated cell sorting
FCM:
FLS:
fibrolast-like synoviocytes
GAPDH:
H&E:
hematoxylin and eosin
HAQ:
Chinese language version of Stanford Health Assessment Questionnaire
IL:
IQR:
JNK:
c-Jun N-terminal kinase
MAPK:
mitogen-activated protein kinase
MMP:
MUT:
mutated sites
NC:
negative control
NF-κB:
nuclear factor-kappaB
Orth.A:
orthopedic arthropathies
p38:
p38 mitogen-activated protein kinase
pain VAS:
pain visual analog scale
PGC-1β:
peroxisome proliferator-activated receptor-gamma coactivator-1 beta
PrGA:
provider global assessment of disease activity
PtGA:
patient global assessment of disease activity
qPCR:
quantitative real-time polymerase chain reaction
RA:
RANKL:
receptor activator of nuclear factor-kappa B ligand
RF:
shRNA:
short hairpin RNA
TNF-α:
tumor necrosis factor alpha
Arend WP, Dayer JM: Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum. 1995, 38: 151-160. 10.1002/art.1780380202.
Firestein GS: Evolving concepts of rheumatoid arthritis. Nature. 2003, 423: 356-361. 10.1038/nature01661.
Komatsu N, Takayanagi H: Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints.Front Immunol 2012, 3:77.,
Jackson JR, Minton JA, Ho ML, Wei N, Winkler JD: Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta. J Rheumatol. 1997, 24: 1253-1259.
Bartok B, Firestein GS: Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010, 233: 233-255. 10.1111/j.0105-2896.2009.00859.x.
McInnes IB, Schett G: Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007, 7: 429-442. 10.1038/nri2094.
Szekanecz Z, Kim J, Koch AE: Chemokines and chemokine receptors in rheumatoid arthritis. Semin Immunol. 2003, 15: 15-21. 10.1016/S1044-5323(02)00124-0.
Nakano K, Okada Y, Saito K, Tanaka Y: Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts. Arthritis Rheum. 2004, 50: 2450-2458. 10.1002/art.20367.
Gibbons LJ, Hyrich KL: Biologic therapy for rheumatoid arthritis: clinical efficacy and predictors of response. BioDrugs. 2009, 23: 111-124. 10.2165/00063030-200923020-00004.
Juarez M, Filer A, Buckley CD: Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer.Swiss Med Wkly 2012, 142:w13529.,
Fujisawa K, Asahara H, Okamoto K, Aono H, Hasunuma T, Kobata T, Iwakura Y, Yonehara S, Sumida T, Nishioka K: Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice. J Clin Invest. 1996, 98: 271-278. 10.1172/JCI118789.
Miagkov AV, Kovalenko DV, Brown CE, Didsbury JR, Cogswell JP, Stimpson SA, Baldwin AS, Makarov SS: NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc Natl Acad Sci USA. 1998, 95: 13859-13864. 10.1073/pnas.95.23.13859.
Tomita T, Takeuchi E, Tomita N, Morishita R, Kaneko M, Yamamoto K, Nakase T, Seki H, Kato K, Kaneda Y, Ochi T: Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum. 1999, 42: 2532-2542. 10.1002/1529-0131(199912)42:12<2532::AID-ANR5>3.0.CO;2-2.
Knutti D, Kaul A, Kralli A: A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol. 2000, 20: 2411-2422. 10.1128/MCB.20.7.2411-2422.2000.
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998, 92: 829-839. 10.1016/S0092-8674(00)81410-5.
Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM: Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem. 2002, 277: 1645-1648. 10.1074/jbc.C100631200.
Eisele PS, Salatino S, Sobek J, Hottiger MO, Handschin C: The peroxisome proliferator-activated receptor gamma coactivator 1alpha/beta (PGC-1) coactivators repress the transcriptional activity of NF-kappaB in skeletal muscle cells. J Biol Chem. 2013, 288: 2246-2260. 10.1074/jbc.M112.375253.
Handschin C: Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation. Clin Exp Pharmacol Physiol. 2009, 36: 1139-1143. 10.1111/j.1440-1681.2009.05275.x.
Xu W, Guo T, Zhang Y, Jiang X, Zhang Y, Zen K, Yu B, Zhang CY: The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1alpha expression. Exp Cell Res. 2011, 317: 1083-1092. 10.1016/j.yexcr.2010.10.006.
Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ, Chawla A: Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006, 4: 13-24. 10.1016/j.cmet.2006.05.011.
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. 10.1002/art.1780310302.
Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D: 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010, 62: 2569-2581. 10.1002/art.27584.
Pessler F, Ogdie A, Diaz-Torne C, Dai L, Yu X, Einhorn E, Gay S, Schumacher HR: Subintimal Ki-67 as a synovial tissue biomarker for inflammatory arthropathies. Ann Rheum Dis. 2008, 67: 162-167. 10.1136/ard.2007.071670.
Koh ET, Seow A, Pong LY, Koh WH, Chan L, Howe HS, Lim TH, Low CK: Cross cultural adaptation and validation of the Chinese Health Assessment Questionnaire for use in rheumatoid arthritis. J Rheumatol. 1998, 25: 1705-1708.
Anderson J, Caplan L, Yazdany J, Robbins ML, Neogi T, Michaud K, Saag KG, O'Dell JR, Kazi S: Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice. Arthritis Care Res. 2012, 64: 640-647. 10.1002/acr.21649.
Singh JA, Arayssi T, Duray P, Schumacher HR: Immunohistochemistry of normal human knee synovium: a quantitative study. Ann Rheum Dis. 2004, 63: 785-790. 10.1136/ard.2003.013383.
Gerlag D, Tak PP: Synovial biopsy. Best Pract Res Clin Rheumatol. 2005, 19: 387-400. 10.1016/j.berh.2005.01.005.
Kawakami A, Nakashima T, Sakai H, Hida A, Urayama S, Yamasaki S, Nakamura H, Ida H, Ichinose Y, Aoyagi T, Furuichi I, Nakashima M, Migita K, Kawabe Y, Eguchi K: Regulation of synovial cell apoptosis by proteasome inhibitor. Arthritis Rheum. 1999, 42: 2440-2448. 10.1002/1529-0131(199911)42:11<2440::AID-ANR23>3.0.CO;2-0.
Takemura S, Braun A, Crowson C, Kurtin PJ, Cofield RH, O'Fallon WM, Goronzy JJ, Weyand CM: Lymphoid neogenesis in rheumatoid synovitis. J Immunol. 2001, 16: 1072-1080. 10.4049/jimmunol.167.2.1072.
Muller-Ladner U, Ospelt C, Gay S, Distler O, Pap T: Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts.Arthritis Res Ther 2007, 9:223.,
Takayanagi H, Iizuka H, Juji T, Nakagawa T, Yamamoto A, Miyazaki T, Koshihara Y, Oda H, Nakamura K, Tanaka S: Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2000, 43: 259-269. 10.1002/1529-0131(200002)43:2<259::AID-ANR4>3.0.CO;2-W.
Huber LC: Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology. 2006, 45: 669-675. 10.1093/rheumatology/kel065.
Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH: Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001, 22: 153-183.
Okazaki Y, Sawada T, Nagatani K, Komagata Y, Inoue T, Muto S, Itai A, Yamamoto K: Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis. J Rheumatol. 2005, 32: 1440-1447.
Kim KW, Kim HR, Park JY, Park JS, Oh HJ, Woo YJ, Park MK, Cho ML, Lee SH: Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts. Arthritis Rheum. 2012, 64: 1015-1023. 10.1002/art.33446.
Suzuki M, Tetsuka T, Yoshida S, Watanabe N, Kobayashi M, Matsui N, Okamoto T: The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts. FEBS Lett. 2000, 465: 23-27. 10.1016/S0014-5793(99)01717-2.
Lin TH, Tang CH, Wu K, Fong YC, Yang RS, Fu WM: 15-deoxy-Delta(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-alpha-induced matrix metalloproteinase 13 production via the antagonism of NF-kappaB activation in human synovial fibroblasts. J Cell Physiol. 2011, 226: 3242-3250. 10.1002/jcp.22685.
Yamasaki S, Nakashima T, Kawakami A, Miyashita T, Ida H, Migita K, Nakata K, Eguchi K: Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activated receptor gamma-mediated signalling pathway. Clin Exp Immunol. 2002, 129: 379-384. 10.1046/j.1365-2249.2002.01876.x.
Olesen J, Larsson S, Iversen N, Yousafzai S, Hellsten Y, Pilegaard H: Skeletal muscle PGC-1alpha is required for maintaining an acute LPS-induced TNFalpha response.PLoS One 2012, 7:e32222.,
Promsong A, Chung WO, Satthakarn S, Nittayananta W: Ellagic acid modulates the expression of oral innate immune mediators: potential role in mucosal protection. J Oral Pathol Med. 2014
Chang B, Amemura-Maekawa J, Kura F, Kawamura I, Watanabe H: Expression of IL-6 and TNF-alpha in human alveolar epithelial cells is induced by invading, but not by adhering, Legionella pneumophila. Microb Pathog. 2004, 37: 295-302. 10.1016/j.micpath.2004.10.002.
Firestein GS: Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?. Arthritis Rheum. 1996, 39: 1781-1790. 10.1002/art.1780391103.
Neidhart M, Rethage J, Kuchen S, Kunzler P, Crowl RM, Billingham ME, Gay RE, Gay S: Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum. 2000, 43: 2634-2647. 10.1002/1529-0131(200012)43:12<2634::AID-ANR3>3.0.CO;2-1.
Kim WU, Kang SS, Yoo SA, Hong KH, Bae DG, Lee MS, Hong SW, Chae CB, Cho CS: Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation. J Immunol. 2006, 177: 5727-5735. 10.4049/jimmunol.177.8.5727.
Aupperle K, Bennett B, Han Z, Boyle D, Manning A, Firestein G: NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes. J Immunol. 2001, 166: 2705-2711. 10.4049/jimmunol.166.4.2705.
Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo LD, Li Q, Guzman JR, Korgaonkar CK, Donner DB: Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. J Biol Chem. 2004, 279: 1615-1620. 10.1074/jbc.M306976200.
Wang LH, Yang XY, Zhang X, Farrar WL: Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. Blood. 2007, 110: 4373-4384. 10.1182/blood-2006-07-038026.
Grant support was provided : National Natural Science Foundation of China (grant no. 81471597), Specialized Research Fund for the Doctoral Program of Higher Education (grant no.20130171110075) and Guangdong Natural Science Foundation (grant no.S2013010014396). We gratefully thank all the patients and the members of the medical staff who generously collaborated with this research.
Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, PR China
Jing-Jing Zhou
, Jian-Da Ma
, Ying-Qian Mo
, Dong-Hui Zheng
, Le-Feng Chen
, Xiu-Ning Wei
& Lie Dai
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Correspondence to Lie Dai.
All authors contributed to the final manuscript. JJZ and JDM contributed equally to this work, participating in the design of the study, carrying out the experiments and statistical analysis, and drafting and revising the manuscript. LD designed the study, collected data, analyzed data, and drafted and critically revised the manuscript. DHZ helped with collection and acquisition of the data and the synovium, and drafted and critically revised the manuscript. LFC helped with collection of the clinical materials, analyzed data and critically revised the manuscript. XNW and YQM assisted with carrying out the experiments and collecting data, analyzed data and critically revised the manuscript. All authors read and approved the final manuscript for publication.
Zhou, J., Ma, J., Mo, Y. et al. Down-regulating peroxisome proliferator-activated receptor-gamma coactivator-1beta alleviates the proinflammatory effect of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting extracellular signal-regulated kinase, p38 and nuclear factor-kappaB activation. Arthritis Res Ther 16, 472 (2014) doi:10.1186/s13075-014-0472-6
Rheumatoid Arthritis Synovium
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MONOLOGO SALOMON PARAMOUNT COMEDY
His father was a surgeon in the Royal Netherlands Army and a colonial official. Walter Chandoha topic Walter George Chandoha November 30, — January 11, was a prolific photographer, known especially for his photographs of animals and particularly of cats. In he tried t The film was released on October 13, , by Paramount Pictures. Fountain of Youth topic The Fountain of Youth, painting by Lucas Cranach the Elder The Fountain of Youth is a spring that supposedly restores the youth of anyone who drinks or bathes in its waters. Union Pacific is a American dramatic western film directed by Cecil B.
Plot A naive country boy named Benny Miller Lou Costello , from Cucamonga, California, has been taking correspondence phonograph lessons in salesmanship. The name Walter Mitty and the derivative word “Mittyesque”[6] have entered the English language, denoting an ineffectual person who spends more time in heroic daydreams than paying attention to the Dumbbell falls in love with Mary Wilde, but they incur the wrath of the Purist’s League delegation, the sheriff, the Clarkes, detectives hired by Mr Clarke, and the gang of crooks intent on kidnapping Marmaduke, Dumbbell, and Mary all meet up together, Dumbbell reveals himself to be Ralph Connor, Secret Service agent, and turns the gang over to the sheriff. One of the 17 films made by the Martin and Lewis team, it was released on April 27, by Paramount Pictures. Member feedback about Walter Lewin: Member feedback about The Ghost Breakers: He and Nicholson have appeared in nine films to
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Walter DeLeon | Revolvy
He goes there with pal Sourpuss and press agent Scoop, transforms the place into a charm school encounters a stranger named Joe who becomes a financial benefactor. He also studied classic ballet, as well as modern ballet. DeLeon or De Leon is a surname. He became an aide for Senator Inouye inwhen Inouye served monoloyo a committee investigating the Watergate scandal, and remained on the senator’s staff for 38 years.
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Tracey Clive Walter born November 25, is an American character actor. Collins based his protagonist on Manhattan defense attorney William Joseph Fallon, dubbed “The Great Mouthpiece” in the New York press, who had a short but spectacularly succes The team was the Copa Libertadores paramoynt, losing the finals against River Plate.
Walter Mercado topic Walter Mercado Salinas[1][a] born 9 March ,[1][2][3][4] also known by his stage name Shanti Ananda, is a Puerto Rican astrologer, actor, dancer, and writer, best known as a television personality for his shows as an astrologer. After DeLeon’s daughter survived pagamount inhe was involved in the establishment of the Emergency Medical Services for Children program.
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On his return, he followed, like many other students of Delaroche, into the atelier of Charles Gleyre and studied there for a brief time. He and Nicholson have appeared in nine films to Member feedback about Lonely Wives: MatildaDeath to Smoochyand Duplex Unfortunately, Benny is fired from his salesman post after only one day. Member feedback about Walter Chandoha: Collins, in which a former prosecutor, disillusioned by sending an innocent man to the electric chair, takes the saying “Better that a hundred guilty men go free than one innocent man suffer the death penalty” one step further by becoming a defense attorney for gangsters and adroitly tightrope walking legal ethics.
PASUPU KUMKUMA SERIAL EPISODE 865
Inhe was graduated from N.
Member feedback about The Spirit of Notre Dame: De Leon combined the rising theories of revolutionary syndicalism in his time with orthodox Marxism.
Fields intends to send his nearly identical younger brother S. He delivers the deed to her inherited plantation and mansion, “Castillo Maldito”, on a small island Fields Revolvy Brain revolvybrain W. He visited Florence, Rome, the Vatican mnologo Pompeii, but he was more attracted to the world of nature.
The show was produced by Henry W. Who will survive the effort to push the railroad through at any cost? Member feedback about Kisses for Breakfast film: He went to Paris in where he studied under Paul Delaroche, whom he accompanied to Italy — Union Pacific is a American dramatic western film directed by Cecil B. Retrieved September 9, The Padres won the game, but Silva did not get the decision.
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Mis-Spliced Transcripts of Nicotinic Acetylcholine Receptor α6 Are Associated with Field Evolved Spinosad Resistance in Plutella xylostella (L.)
Simon W. Baxter, Mao Chen, Anna Dawson, Jian Zhou Zhao, et al
https://dx.plos.org/10.1371/journal.pgen.1000802
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1000802
http://www.mendeley.com/research/misspliced-transcripts-nicotinic-acetylcholine-receptor-%CE%B16-associated-field-evolved-spinosad-resista
Is documented by
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http://doi.org/10.1002/ps.5240
http://doi.org/10.1016/j.pestbp.2011.11.004
http://doi.org/10.1016/j.ibmb.2016.04.007
http://doi.org/10.1111/imb.12014
http://doi.org/10.1016/j.aspen.2017.04.013
http://doi.org/10.1002/arch.21245
http://doi.org/10.1093/jee/toy409
http://doi.org/10.1016/j.cropro.2017.12.028
http://doi.org/10.1584/jpestics.D17-019
http://doi.org/10.1016/j.cois.2018.03.005
http://doi.org/10.1146/annurev-ento-120811-153605
http://doi.org/10.1038/ja.2010.5
http://doi.org/10.1111/jnc.12029
http://doi.org/10.1093/jee/tou060
http://doi.org/10.1603/EN11144
http://doi.org/10.3389/fphys.2017.00130
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{"files"=>["https://ndownloader.figshare.com/files/868315"], "description"=>"<p>Genes flanking <i>nAChR Pxα6</i> were chosen for genotyping based on relative position within the <i>B. mori</i> genome (distances are shown). Susceptible and resistant alleles were inherited in untreated controls at a ∼1∶1 ratio. The 3′ end of <i>nAChR Pxα6</i> was completely linked to the spinosad resistance locus.</p>", "links"=>[], "tags"=>["spinosad"], "article_id"=>538769, "categories"=>["Molecular Biology", "Evolutionary Biology", "Genetics"], "users"=>["Simon W. Baxter", "Mao Chen", "Anna Dawson", "Jian-Zhou Zhao", "Heiko Vogel", "Anthony M. Shelton", "David G. Heckel", "Chris D. Jiggins"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000802.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Recombinational_map_of_the_Plutella_xylostella_spinosad_resistance_locus_PxSpinR_/538769", "title"=>"Recombinational map of the <i>Plutella xylostella</i> spinosad resistance locus, <i>PxSpinR</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-08 02:26:09"}
{"files"=>["https://ndownloader.figshare.com/files/868365"], "description"=>"<p>(A) Intron distances and relative exon sizes of <i>nAChR Pxα6</i> from Geneva 88 BAC clone Px8d14. Exon variants 3a, 3b, 8b, and 8c are shown. Scale bars differ for intron length and exon size. Introns 1 and 4 contain sequencing gaps. (B) <i>nAChR Pxα6</i> coding sequence, containing exons 3a and 8b. The predicted N-terminal signal leader peptide (probability = 0.988) is shown with a dashed line. The four transmembrane domains are underlined in bold (TM1-4), signature cysteines of nAChR alpha subunits are double underlined and neurotransmitter-gated ion-channels signature of cysteines, separated by 13 amino acids, shown with stars. Intron positions are shown in numbered boxes. PCR primers in the 5′ and 3′ UTRs (shaded boxes) amplified a product from cDNA of Geneva88 4<sup>th</sup> instar larvae (GenBank GU207835).</p>", "links"=>[], "tags"=>["coding"], "article_id"=>538818, "categories"=>["Molecular Biology", "Evolutionary Biology", "Genetics"], "users"=>["Simon W. Baxter", "Mao Chen", "Anna Dawson", "Jian-Zhou Zhao", "Heiko Vogel", "Anthony M. Shelton", "David G. Heckel", "Chris D. Jiggins"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000802.g003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_nAChR_Px_945_6_g_ene_and_coding_sequence_/538818", "title"=>"<i>nAChR Pxα6 g</i>ene and coding sequence.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-08 02:26:58"}
{"files"=>["https://ndownloader.figshare.com/files/868610"], "description"=>"<p>(A) Schematic of a full-length transcript, with four transmembrane domains. Two exon 3 variants, 3a or 3b, were observed through cloning. (B) Summary of transcripts observed from PCR amplification between exons 2 and 12. PCR 1 was performed with primers Pxα6_ex2_F and Pxα6_ex12_R3, products excised from agarose gels and reamplified with nested PCR 2 using primers Pxα6_ex2_F and Pxα6_ex12_R2. Amplicon sizes are shown in base pairs (bp). Isoform names are provided in general accordance with Rinkevich and Scott <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000802#pgen.1000802-Rinkevich1\" target=\"_blank\">[29]</a> or new isoform numbers assigned. (C) Summary of transcripts from PCR between exons 7 and 11. PCR 3 was amplified with Pxα6_ex6F and Pxα6_ex12R, products column purified and reamplified with PCR 4, Pxα6_ex7_F and Pxα6_ex11_R. All clones sequenced from the resistant strain contained premature stop codons (black triangles). There were no stop codons or change in reading frame observed in clones from the susceptible strain. Insertions of 30, 40, or 4 base pairs are shown with dashed lines.</p>", "links"=>[], "tags"=>["nachr", "splice", "resistant", "susceptible"], "article_id"=>539061, "categories"=>["Molecular Biology", "Evolutionary Biology", "Genetics"], "users"=>["Simon W. Baxter", "Mao Chen", "Anna Dawson", "Jian-Zhou Zhao", "Heiko Vogel", "Anthony M. Shelton", "David G. Heckel", "Chris D. Jiggins"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000802.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_nAChR_Px_6_splice_variation_in_resistant_and_susceptible_Plutella_xylostella_larvae_/539061", "title"=>"Summary of nAChR Pxα6 splice variation in resistant and susceptible <i>Plutella xylostella</i> larvae.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-08 02:31:01"}
{"files"=>["https://ndownloader.figshare.com/files/868518"], "description"=>"<p>(A) Schematic diagram of the four nAChR transmembrane domains (TM1-4). A premature stop codon in the resistant BCS3-Pearl strain is denoted with a star in the intracellular loop. The subunit region predicted to be missing is shown with dashed lines. (B) DNA sequence of intron 9 from the susceptible strain (first 45 bp), and equivalent region in the resistant strain. Intronic GT splice sites are boxed. A G→A point mutation in the resistant strain (bold) results in a mis-splicing event that introduces this 40 bp sequence into mRNA and introduces a premature stop codon. (C) The peptide sequence between exon 9 and 10 of the susceptible strain and truncated product of the resistant strain. Conserved bases or amino acids are shown with an asterisk (*).</p>", "links"=>[], "tags"=>["mutation", "nachr", "spinosad", "resistant"], "article_id"=>538968, "categories"=>["Molecular Biology", "Evolutionary Biology", "Genetics"], "users"=>["Simon W. Baxter", "Mao Chen", "Anna Dawson", "Jian-Zhou Zhao", "Heiko Vogel", "Anthony M. Shelton", "David G. Heckel", "Chris D. Jiggins"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000802.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Truncating_mutation_of_nAChR_Px_6_in_spinosad_resistant_Plutella_xylostella_/538968", "title"=>"Truncating mutation of nAChR Pxα6 in spinosad resistant <i>Plutella xylostella</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-08 02:29:28"}
{"files"=>["https://ndownloader.figshare.com/files/431233", "https://ndownloader.figshare.com/files/431269", "https://ndownloader.figshare.com/files/431299", "https://ndownloader.figshare.com/files/431336"], "description"=>"<div><p>The evolution of insecticide resistance is a global constraint to agricultural production. Spinosad is a new, low-environmental-risk insecticide that primarily targets nicotinic acetylcholine receptors (nAChR) and is effective against a wide range of pest species. However, after only a few years of application, field evolved resistance emerged in the diamondback moth, <em>Plutella xylostella</em>, an important pest of brassica crops worldwide. Spinosad resistance in a Hawaiian population results from a single incompletely recessive and autosomal gene, and here we use AFLP linkage mapping to identify the chromosome controlling resistance in a backcross family. Recombinational mapping with more than 700 backcross progeny positioned a putative spinosad target, nAChR alpha 6 (<em>Pxα6</em>), at the resistance locus, <em>PxSpinR</em>. A mutation within the ninth intron splice junction of <em>Pxα6</em> results in mis-splicing of transcripts, which produce a predicted protein truncated between the third and fourth transmembrane domains. Additional resistance-associated Pxα6 transcripts that excluded the mutation containing exon were detected, and these were also predicted to produce truncated proteins. Identification of the locus of resistance in this important crop pest will facilitate field monitoring of the spread of resistance and offer insights into the genetic basis of spinosad resistance in other species.</p></div>", "links"=>[], "tags"=>["mis-spliced", "transcripts", "nicotinic", "acetylcholine", "receptor", "are", "evolved", "spinosad"], "article_id"=>145099, "categories"=>["Molecular Biology", "Evolutionary Biology", "Genetics"], "users"=>["Simon W. Baxter", "Mao Chen", "Anna Dawson", "Jian-Zhou Zhao", "Heiko Vogel", "Anthony M. Shelton", "David G. Heckel", "Chris D. Jiggins"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000802.s001", "https://dx.doi.org/10.1371/journal.pgen.1000802.s002", "https://dx.doi.org/10.1371/journal.pgen.1000802.s003", "https://dx.doi.org/10.1371/journal.pgen.1000802.s004"], "stats"=>{"downloads"=>4, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Mis_Spliced_Transcripts_of_Nicotinic_Acetylcholine_Receptor_6_Are_Associated_with_Field_Evolved_Spinosad_Resistance_in_Plutella_xylostella_L_/145099", "title"=>"Mis-Spliced Transcripts of Nicotinic Acetylcholine Receptor α6 Are Associated with Field Evolved Spinosad Resistance in <em>Plutella xylostella</em> (L.)", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-01-08 01:24:59"}
{"files"=>["https://ndownloader.figshare.com/files/868230"], "description"=>"<p>146 AFLP genotypes were generated from a female informative backcross and assigned into 30 linkage groups. χ<sup>2</sup> values for each linkage group were calculated by comparing genotypes inherited by backcross spinosad bioassay survivors with untreated controls. A directional bias towards spinosad susceptible or resistant grandparental origin is shown. Linkage group 1 (LG01) was significantly associated with spinosad resistance after Bonferroni correction for multiple comparisons (LG01, χ<sup>2</sup> = 15.53, P>0.0001). The remaining 29 linkage groups identified here were not associated with resistance. LG-Z is the sex chromosome.</p>", "links"=>[], "tags"=>["linkage"], "article_id"=>538686, "categories"=>["Molecular Biology", "Evolutionary Biology", "Genetics"], "users"=>["Simon W. Baxter", "Mao Chen", "Anna Dawson", "Jian-Zhou Zhao", "Heiko Vogel", "Anthony M. Shelton", "David G. Heckel", "Chris D. Jiggins"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000802.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spinosad_resistance_is_associated_with_a_single_linkage_group_in_Plutella_xylostella_/538686", "title"=>"Spinosad resistance is associated with a single linkage group in <i>Plutella xylostella</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-08 02:24:46"}
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A Brain-Computer Interface Based Attention Training Program for Treating Attention Deficit Hyperactivity Disorder
Choon Guan Lim, Tih Shih Lee, Cuntai Guan, Daniel Shuen Sheng Fung, et al
http://www.mendeley.com/research/braincomputer-interface-based-attention-training-program-treating-attention-deficit-hyperactivity-di-1
CiteULike29 Apr 13:15 UTC
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http://doi.org/10.1051/matecconf/201712108006
http://doi.org/10.2196/games.5888
http://doi.org/10.1109/TBME.2016.2628958
http://doi.org/10.1145/3131607
http://doi.org/10.1080/0144929X.2018.1544276
http://doi.org/10.3390/ijerph120606261
http://doi.org/10.1016/j.neuropsychologia.2015.09.012
http://doi.org/10.3389/fpsyt.2015.00151
http://doi.org/10.3389/fnsys.2015.00027
http://doi.org/10.1089/g4h.2015.0103
http://doi.org/10.1108/IJCS-09-2018-0022
http://doi.org/10.1016/j.tine.2019.100113
http://doi.org/10.1109/ACCESS.2019.2953535
http://doi.org/10.3389/fpsyg.2014.00183
http://doi.org/10.3389/fnhum.2018.00524
http://doi.org/10.1016/j.ijpsycho.2013.09.004
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Georgetown Magazine (11) Apply Georgetown Magazine filter
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University Receives Two Awards Commending its Leadership for Veterans
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Former U.S. Attorney General Eric Holder Talks Race and Challenging Status Quo
Five Memorable Quotes from Georgetown Commencement Speeches
Each year, accomplished leaders in top areas such as business, government and entertainment set out to inspire, empower and encourage new classes of graduates at commencement. Even when the...
Georgetown Alumnus Embraces Local Veteran Community
Sean Sheppard (C’90) believes that service to others is a value best instilled at a young age. His nonprofit organization, Embrace , seeks to mobilize local college students to help those in need in...
Stacey Plaskett (F’88) Honored with Samuel A. Halsey Jr. Award
On January 16, Rep. Stacey Plaskett (D-Virgin Islands) (F’88) was honored with the 2016 Samuel A. Halsey Jr. Award, presented at the annual Patrick Healy Awards Dinner. The award, created in honor of...
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$10M Gift Will Create U.S.-China Initiative on Global Issues
A $10 million gift from the Hong Kong based Spring Breeze Foundation will support a new university Initiative for U.S.-China Dialogue on Global Issues. The initiative will bring together leaders from the public sector, business, and academia to address common challenges facing the global...
MLK Jr. Day of Service
The 2016 Georgetown Martin Luther King Jr. Day of Service takes place on Saturday, January 23 . This day of service and togetherness will unite the Georgetown community, the Cesar Chavez Public...
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We Are Where We Eat
Dining halls have always dished out more than meals. No matter what's for dinner, our appetite is for friendship.
Creating a Special Connection for Black Alumni
More than 200 Black alumni—including CEOs, entrepreneurs, artists, activists, and elected officials—returned to the Hilltop last October for the second Black Alumni Summit.
Community Scholars Program Celebrates 50-Year Anniversary
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College Establishes Minor in Disability Studies
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A Farewell to Sursum Corda: Tutoring Program Reaches Final Chapter
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Given Georgetown’s commitment to social justice, it’s no surprise that many alumni—even those who didn’t start out in a media career—have found their way to documentary film making.
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Women’s Soccer Team Makes History in 25th Year
In the past two years, the women’s soccer team members smashed every goal they set for themselves.
Staging all the World
Behind the scenes, an ambassador and a theater professor wield the power of performances to affect political change in Washington, D.C., and across the globe.
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G ziemelis how your heavy coat can cut airline s profit
G. Ziemelis: How your heavy coat can cut airline's profit?
It is a well known fact that aviation business is an expensive pleasure. In order not to lose their space in the market by constantly increasing ticket prices, airlines take a different route and shift their focus on reducing operational costs to increase their profit.
Probably the best known example of incredible savings achieved by the smallest decision is the story of an olive. In the 1980s, American Airlines were looking for ways to cut costs when their calculations showed, that cutting out just one item from passengers’ meals would do the trick. By simply removing one olive from the salads served in-flight, the airline saved a staggering $40,000 in the course of a single year. This olive choice was not only a way to decrease the in-flight food costs, but also to save on fuel costs. While a single olive might not weigh much, a year worth of these "single olives" add up.
Similarly to the olive case, Northwest Airlines saved $500,000 a year, by slicing its limes - that were to be served in soft drinks - into 16 slices instead of 10. So every little thing counts.
Recently most airlines have been focusing on reducing their fuel costs by "weighing" less. American carrier United began printing its in-flight magazine on lighter paper, saving 28 grams per copy. It might not sound like much, but they calculated that it saves the company 643,000 liters of fuel and $300,000 a year.
In 2017 United stopped on-board sales of duty-free items - such as perfumes, chocolates and liquor - cutting 5.2 million liters of fuel a year and saving a staggering $2.3 million.
Virgin Atlantic tackled the issue by making its glassware thinner and removing some of its heavy, slate plates from the upper class. According to the airline's estimates, losing a pound (0.45kg) in weight from every plane in its fleet would save 53,000 liters of fuel a year.
The Thomas Cook airline decided to stop printing receipts for in-flight purchases and by doing that saving it the need to carry 420,000 till rolls across its fleets. The company has also reduced the number of spare pillows and blankets it carries from four down to two.
And while the above mentioned means of saving don't sound bad, some airlines take a slightly different approach.
In 2009, Japanese airline All Nippon Airways asked passengers to visit the lavatory before boarding in hopes that the weight saved would lead to a five-ton reduction in carbon emissions - and a small cost saving.
An even crazier decision was made by Samoa Air in 2013, when they introduced a "fat tax", where passengers would be charged a fare according to their weight. At the time the CEO of the airline explained that they were not selling seats, but selling weight.
And if such craze to reduce everything to save costs continues, we might soon be asked to leave even our phones at home. Researchers at MIT have estimated that each passenger carrying a phone on Southwest Airlines cost it $1.2million a year in weight-related fuel expenses. The cost jumps to $21.6million if the phones were swapped for laptops.
Clearly, airlines cannot reduce everything to save their profits, but they sure try to.
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Board & Non-Exec Appointments
Public SectorFDAdmin2019-10-27T16:43:08+00:00
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Posts Tagged ‘Leon Russel’
Posted in Uncategorized, tagged growing older, Leon Russel, rock and roll, State Theater on February 6, 2011| Leave a Comment »
We went into town last Saturday evening to see Leon Russell at the State Theater. It was a still, crisp night, with ice crusting on the snow. The men’s basketball game was letting out at the Bryce Jordan Center as we passed, and the long line of cars poked along Park Avenue, white headlights streaming for a mile ahead.
We were running late and so we changed our plans for a slow Italian meal at Mario and Luigi’s and headed downtown to find what was open. We tried the new Thai place on Allen Street, but there was a wait, so my wife and I ended up at the Green Bowl, eating stir fry elbow to elbow with a crowd of college students. They glowed with health and confidence, and I envied them their clear skin and shining hair, while the room buzzed with the energy of their great expectations.
Leon Russell had been a beautiful, slender youth forty years ago when he put on a top hat and led the ragged carnival called Mad Dogs and Englishmen across the country to the beat of his cacophonous keyboards. He was the king of the session musicians, maybe the greatest rock and roll keyboardist of them all. Other singers made his songs into hits, but none of them had his way with the rolling thunder of his music and voice.
The Leon who made his way onto the stage with the help of a cane was not the slender circus ringmaster that all of us middle aged hipsters and one-time tied-dyed hippies had longed to see. Time had turned the ringmaster into a monument, a sitting Buddha in a cowboy hat and sunglasses. He seemed to be carved out of white jade as he settled in behind the electric piano.
Then his hands moved and the sound exploded for ninety minutes with barely a pause for breath, either for Leon or the rest of us leaning forward into the light. He moved only from the elbows to the fingers, and his voice struggled to climb over the piano and the four-piece band of young players in motley caps who were strutting his former part on the stage.
I worried for his voice as he flew through a dozen of his best known songs, dropping out notes and syllables, the lyrics barely audible. The music soared, but the voice was struggling. Then he sent the band off, and he was alone with the piano. The old, beloved voice came back stronger, and the words were clear as he slowed the moment and swam up through the pool of dreams in Masquerade and A Song for You, the way I had hoped to hear them in the weeks I had waited for his arrival.
We walked out onto the frozen sidewalks of downtown, hundreds of us walking carefully for fear of falling, shuffling like old people. We turned down the block at Fraser Street where Leon’s tour bus was parked. I hoped someone was holding his elbow to keep him from toppling over and shattering on the ground.
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Violence In General - Part One
Sponge-Headed Scienceman and I were disagreeing about something at Bible Study – I know, our children will find it difficult to believe that anyone could ever disagree about anything in that group – and I thought I would like to open it out for discussion.
His contention, simplest version, is that culture and environment have considerable effect on outbursts of violence, and that violent video games in specific increase violence in some people. My contention, simplest version, is that one would think so, but the general trend is the other way – we have a declining violent crime rate as entertainment gets more violent – and evidence has been lacking.
To that end, he sent me this research, and this essay byCharles Krauthammer, who I respect and often agree with. I, of course, want to defend my POV simply because it’s mine, and am not giving these a fair shake, because that’s who I am. Such has long been understood by those who know me. For my own self-regard, however, I like to appear as objective as possible before disagreeing. Plus, the two links actually do have strength, and I have some agreement.
Additional: SHS offered the increased incarceration rate as a partial explanation for the reduction in violence, and I don’t disagree. He did not develop that idea at any length, but that’s in his mix. What else is there that he might think are factors we haven’t gotten to yet.
First, I would like to thank the researchers for doing some of my work for me. I have had some contact with research exploring whether x increases or reduces violence for forty years or so, but I haven’t followed it closely. I’ve just picked up things here and there over the years, sometimes professionally, sometimes just from general stuff I read. So it saved me a lot of reading when they tell me that certain connections between violent material and desensitisation to violence have been demonstrated, but others haven’t. I suspected that, because that has been the case repeatedly for years – researchers want to show that stuff they disapprove of is bad for you, but have trouble locking the case down. It was nice to know that hadn’t changed much.
This research does take a step in that direction, however. It’s not just about activation and arousal, which we observed well before we could watch it in the brain, but about actual bad behavior. Subjects willingly did worse things to other people after being exposed to certain types of violence. There’s a limit to how far you can go in testing this stuff. You can’t run folks through a bunch of different possibilities, then kick them out the door with guns and see which group shoots the most people. By its very nature, you have to look at a lot of indirect evidence and likely precursors to violence, rather than violence itself. The test design was pretty clever in trying to get around that.
But I don’t think they get there, for more than one reason. Nor does Krauthammer, who remarkably does not employ the reasoning in one paragraph of his essay to a later paragraph.
Folks can anticipate where I'm going or begin to weigh in on their own. But for openers, you can look at the language the researchers use to introduce their topic.
John Cunningham said...
I highly recommend a 1999 book by Col. DAve Grossman, Stop Teaching Our Kids to Kill. he makes the point that highly realistic first person shooter games train kids in shooting and seriously de-sensitize them to killing humans. he cites hundreds of studies supporting this conclusion.
Dubbahdee said...
Grossman's book "On Killing" goes into detail regarding the psychology of killing, specifically in regards to training soldiers. The follow up "On Combat" explores the effects of such training on the psyche of the trained.
Is it possible that the limited cohort exposed to these games (young men under X age) produces a small sub-population disposed to asocial mass violence. The crime rate in the overall population may be reduced, while the rate of incidence of a specific kind of violence ("asocial mass violence) is going up due to the desensitization of this particular sub group?
A question much on my mind. The opening answer is that this is hypothesised, but no evidence has been found to support it. However, the population that does these terrible things is so small that it is hard to measure with any degree of assurance what exactly is pushing them from contemplation to crime.
I will be bringing in the forensic information of what factors increase risk in predicting which mentally ill people who have committed crimes will reoffend. That is not quite the same question, but it is related. Violent games or the other things which make the op-ed page are not even on the radar in that literature.
What about research re: the effects of widespread prescription of anti-depressants on the same young population -- and their tendency to produce harmful behaviors in young patients?
A possible combination/intersection of two forces.
Probably no research on this either, but another interesting hypothesis. I've been hearing noise about it.
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Unwarranted Assumption
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Man Finally Put In Charge Of Struggling Feminist M...
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Doctors And Statistics
The Sadness of NHH Christmas
Wyman Family Christmas Letter 2012
Racialism and Nationalism
Depression Lies
Celebrity Opinions
Tinfoil Hats
One Perspective
Me 'n IQ
Isaiah's Job
Political and Social Versus Spiritual
Post 3900 - Right To Work
Impulsive Solutions
Walkin' In Memphis
Fashionable Politics - The Long Wave
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Again With the "Fashionable Politics."
Fashionable Politics
Norwegian Law
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2019 Holiday Tournament
Follow the Team on Twitter!
Capital Falls Just Short to Washington & Jefferson
Washington & Jefferson (5-2,0-0 PAC) 9 15 19 24 67
Capital (3-2,0-0 OAC) 12 17 17 14 60
Pts: Lauren Gilbert - 20
Reb: Alie Seto - 10
Ast: Aleena McDaniel - 3
Pts: Emma Burns - 17
Reb: Regan Stonerock - 9
Ast: Caroline Taphorn - 9
By: Allison Lowe, assistant sports information director
COLUMBUS, Ohio - The Capital University women's basketball team dropped a 67-60 decision to Washington & Jefferson College Saturday afternoon at the Capital Center. With the loss, the Crusaders fall to 3-2 on the year while the Presidents improve to 5-2.
Sophomore Emma Burns (Westerville, Ohio/St. Francis Desales) paced Capital with 17 points and three steals. Senior Regan Stonerock (Circleville, Ohio/Westfall) put up 14 points and nine boards. Junior Caroline Taphorn (Harrison, Ohio/McAuley) scored five points and led the team with nine assists. Eight Crusaders put points on the board. Lauren Gilbert led Washington and Jefferson with 20 points and seven rebounds.
Capital came out to score the first basket of the game before the Presidents went on to score nine unanswered points. The Crusaders made a comeback to outscore the Presidents, 12-9 in the first quarter. Stonerock scored six points for the Crusaders with a layup and two jumpers. Junior Carlie Hulette (Cincinnati, Ohio/Oak Hills) put four points on the board and Burns added two for the Purple and White.
Washington and Jefferson shot 4-4 at the free-throw line in the second quarter, but the Crusaders held the lead throughout, out-scoring the Presidents 17-15. Burns picked up the momentum in the second, scoring nine points, which included two three-pointers. Stonerock, Bosch, Hulette, and Wachtman each scored a basket for the Purple and White.
The Presidents tied up the score with 5 minutes left in the third, but neither team could maintain a steady lead. Although the Presidents outscored the Crusaders 19-17, Capital held onto the lead heading into the final quarter. Taphorn when 1-1 on the free-throw line and scored on both her field goal attempts, earning 5 points. Stonerock put up six points and had three rebounds.
Washington & Jefferson took the ball and ran with it late in the fourth quarter, going ahead 57-56. However, Capital took back the lead, scoring on two free throws. The Presidents went on a 9-2 run with 2:27 left in the game, securing a seven-point win over the Crusaders. Burns scored six points and sophomore Brooke Ommert (Wakeman, Ohio/Western Reserve) put five on the board for the Purple and White.
The Crusaders will take on Otterbein University at 5 p.m. Saturday at the Rike Center.
Sat, 01/18 | Women's Basketball vs. John Carroll L, 51-49 (Final) RC | BX
Wed, 01/15 | Women's Basketball at Marietta L, 84-66 (Final) RC | BX
Sat, 01/11 | Women's Basketball vs. Mount Union L, 68-65 (Final) RC | BX | PH
Wed, 01/08 | Women's Basketball vs. Wilmington W, 81-76 (Final) RC | BX
Sat, 01/04 | Women's Basketball at Baldwin Wallace L, 61-56 (Final) RC | BX
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Atlanta’s Rabbi Micah Lapidus Creates New Album With Original Spiritual Songs
By Summer Evans
Rabbi Micah Lapidus has released a spiritual album with 18 original songs called “Hello, Goodbye and Peace.” The songs encapsulate both Jewish and Universalistic ideals. (Summer Evans/WABE)
In 2017, Rabbi Micah Lapidus wrote a song in honor of the Atlanta Falcons playing in the Super Bowl.
“Rise Up” became the unofficial rallying cry for Falcons fans. The music video included Congressman John Lewis. The rabbi was thrilled that “Rise Up” took on a meaning for several Atlanta communities beyond football.
Now he has released a spiritual album with 18 original songs called “Hello, Goodbye and Peace.” The songs encapsulate both Jewish and Universalistic ideals.
“City Lights” host Lois Reitzes sat down with Rabbi Lapidus to discuss the new album.
“One of the things that I appreciate about this particular album is the opportunity to explore so many different aspects of the human experience from mindfulness to the peaks and valleys in all of our journeys to some of the spiritual resources that sustain us through the difficult times to the ways we express gratitude with life’s blessings,” Rabbi Lapidus said.
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HomeThomas Ballard of James City County, Virginia (1630-1690).Thomas Ballard, Jr of York County, Virginia (c.1655-1710).John Ballard of Yorktown, Virginia (1700-1745).Robert Ballard of Princess Anne County, Virginia (1733-1770).
Robert Ballard, the son of John Ballard of Yorktown, Virginia (1700-1745), was born 8 August 1733. The John Ballard Family Bible recites that on “Wednesday, the 8th day of August 1733 at eleven a clock at night, my wife was delivered of a boy baptized 21st, Ism Moody & John Gibbons Godfathers & Mary Hanes Godmother – Baptised by the Rev. Rup. Hewit Minister of Warwick, named him Robert.”1
Robert was John Ballard’s last surviving male heir, having inherited by virtue of the law of primogeniture all of the land that had been devised to his elder brothers, and disposing of it in due course. John had devised to his eldest son Thomas Lot 54 in Yorktown, and we see that on 28 May 1761 “Robert Ballard of the Town and County of York merchant and Anne his wife, for £500, sold to John Thompson of same place merchant, a ½ acre lot of ground where the said Robert Ballard lived in the Town of York No. 542 on the plan of the town which was granted to John Ballard, father of the said Robert by patent, dated 6 May 1727, also two lotts or 1 acre of ground in the said town adjacent to two lots of the same town formerly belonging to Capt Wm Rodgers and in the possession of James Pride esqr which were denoted in the plan or survey of said town land with Nos. 51 & 55 and purchased by the said John Ballard, father of the said Robert, of Gwyn Read and Dorothy his wife on 16 January 1737 … proved 20 July 1761.3
He had removed to Princess Anne County, where on 25 May 1762, “Robert Ballard of Princess Anne Co. gent and Anne his wife, for £200, sold to John Norton of the Town and Co. of York merchant, a 130 acre tract of land in Yorkhampton Parish formerly belonging to John Ballard, father of the said Robert, adjacent Edward Baptist, Edward Potter dec’d, William Young, William Lightfoot, Griffin Stith & the said John Norton … proved 21 June 1762.”4
This would be the plantation devised to the eldest son Thomas, described in the will thusly: “also my Plantation near York Town called Rich Neck Joining to the Land of Edward Baptist.” The law of primogeniture would prescribe that the land descend to the surviving male heir, absent instructions in the will of the testator. We know from the John Ballard Family Bible that Thomas died at sea unmarried and without heirs in September 1747. The will specified that if John or Robert should die before reaching the age of 21, the land would go to his son William — and that did not happen, either. We know William removed to Norfolk c. 18 June 1770, which leads to the conclusion that Robert’s two elder brothers pre-deceased him, since the plantation became vested in Robert.
Records illustrating his activities in Princess Anne County are preserved among the loose papers of that county, and have been published by the The Virginia Antiquary, edited by John Harvie Creecy (1954).
Pursuant to an order of Princess Anne County Court bearing Date the 21th July 1762, We the Subscribers met and appraised the value of the following Slaves at the Death of Mrs. Frances Moseley who died in the Year 1758, viz Judah at sixty Pounds Max at sixty five Hannah at fifty five Peter fifty Pounds and China at forty five Pounds, and this we give as our Report Given under our Hands this 11th August 1762. John Whitehurst, Nathl McClenahan, Robert Ballard. Princess Anne Co. Va. Loose Papers, 1700-1789 [ Box A 3]
29 Oct. 1764. John Bishop’s note to Robert Ballard for £4:13:6 was witnessed by John Lovett Junr. Princess Anne Co. Va. Loose Papers, 1700-1789 [Box A 5, marked 1764]
1765-66. Account of Marshall Anderson to Ballard & Newton. £6:9:10 due for various supplies, including one ship axe. Princess Anne Co. Va. Loose Papers, 1700-1789 [Box A 7, marked 1766]
7 Oct. 1766. Capias for Francis Beekley to answer Ballard & Newton of a plea of Trespass on the Case, damage £12. John Woodhouse, bail. Princess Anne Co. Va. Loose Papers, 1700-1789[Box A 7, marked 1766]
16 Aug. 1767. Robert Ballard signed a bond to Thomas Philpot of the city of London. John Lovett Junr was witness. Princess Anne Co. Va. Loose Papers, 1700-1789 [ Box A 16]
9 Sept. 1767. Capias for Joseph Calvert, Cornelius Calvert, and Saunders Calvert to answer Tully Robinson of a plea of debt for £400, damage £50. Executed on the defendants, & Robert Ballard & Fred: Boush bail, per Fred Boush, S. S., Sept. 1767. Dismissed Oct. 1768. Princess Anne Co. Va. Loose Papers, 1700-1789 [Box A 10]
Plea of Trespass on the Case Damage Ten pounds and have then there this Writ. Witness Robert Ballard Clerk of our said Court, at the Court-House aforesaid, the Nineteenth Day of May 1768 in the Eighth Year of our Reign. Robt Ballard Princess Anne Co. Va. Loose Papers, 1700-1789 [Box A 10]
16 March 1769. Summons for Robert Ballard, Gent., to answer James Kempe, Gent., Frederick Boush, and Walter Lyon, in Chancery. Abates July Court 1770 by the defendant’s death. Princess Anne Co. Va. Loose Papers, 1700-1789 [Box A 12]
26 Jan. 1771. Capias for Lemuel Newton, adm’r with the will annexed of Robert Ballard, Gent., deceased, to answer William Keeling, son of Adam, and Smith Shepherd, ex’ors of the last will of Sarah Weblin deceased of a plea of debt for £80, damage £20. Princess Anne Co. Va. Loose Papers, 1700-1789 [Box A 13]
In 1761-70 he was Clerk of Princess Anne County, and died before 8 November 1770, when the sale of his plantation by the administrator of his estate was advertised in The Virginia Gazette:
Pursuant to a decree of the worshipful Court of Princess Anne county, on Tuesday the 20th day of November next, will be exposed for sale, on the premises, One hundred and fifty-eight acres of choice land, lying and being within about a mile’s distance from the pleasure house, near the mouth of Lynhaven river, in the said county of Princess Anne, being very convenient for fishing and fowling; and on the said premises are a two story brick house, a kitchen with a brick chimney, a large barn and stable, and other convenient buildings, a good garden and extraordinary apple and peach orchards. The cleared part of the said land, which will be sufficient to employ four good hands, is suitable for all kind of grain, and the other is well timbered. The above tract of land is part of the estate of the late Robert Ballard, Gentleman, deceased, and will be sold on three months credit, the purchaser giving bond, with approved security to Lemuel Newton, Administrator.5
He married Anne Newton, the daughter of Nathaniel Newton and Elizabeth Sayer, who was the daughter of Charles Sayer, the former Clerk of Princess Anne county (1716-1740) (“Abstracts from Princess Anne Marriage Licenses (1765)”, William & Mary College Quarterly Historical Papers, Vol. 2, No. 2 (Oct. 1893), pp. 73-77, Note 1).
His will dated 11 September 1769, recorded 5 July 1770 appears in Princess Anne Co. Va. Deed Book 12, p. 56. We have not seen the will, but a published abstract states that it names his wife Ann and his four daughters Elizabeth, Ann, Catherine and Margarett. The executors were his wife Ann, brother-in-law Samuel Boush, Capt. Thomas Newton and his brother William Ballard. The witnesses were William Ballard, Thomas Abbott, Priscilla Consaulvo. Although his brother William was named as an Executor, he did not participate in the management of the estate.
Records relating to his estate are as follows:
4 April 1771. Anne Ballard relict of Capt. Robert Ballard releases dower right for 168 acres for £47, 4 shillings, 5 pence to brother Lemuel Newton. Witnesses: Edward Cannon, Jacob Keeling, John Cuninghame. Recorded Princess Anne Co. Va. Deed Book 12, p. 151.
15 January 1771. Lemuel Newton, Admin. of Robert Ballard, to William Moseley, son of Francis, by a chancery decree between Robert Williamson, Charles Gasking, Exrs, & Elizabeth Biddle, Extrx of John Biddle, and Lemuel Newton, Admnr, Elizabeth, Catherine, Anne and Margaret Ballard — said Newton should sell a tract of 168 acres for £250. Witnesses: Edward Cannon, Jacob Keeling, James Lovitt, John Cuninghame. Recorded Princess Anne Co. Va. Deed Book 12, p. 152.
10 December 1772. Appraisal of estate of Robert Ballard by James Kempe, George Logan, Thomas Abbott. Recorded Princess Anne Co. Va. Deed Book 13, p. 119.
We find evidence of Anne having married David McClenahan in the following deed.
4 July 1771. David McClenahan & wife Anne, late widow of Robert Ballard, Dec’d, to William White for £44, 4 lots at Kempe’s Landing. Witnesses: John Hancock, Eldred Fisher, Jonathan Ellback, William Keeling, Sr. Recorded Princess Anne Co. Va. Deed Book 12, p. 191.
Their children were:
Elizabeth (Betsy), who married in 1775 Rev. Robert Andrews of York County. Robert Andrews married secondly Mary, daughter of Judge John Blair, who was born in 1758 and died without issue on 19 January 1820. The issue of Robert Andrews and Elizabeth Ballard were 1. Anne, who married William Randolph of Wilton; 2. Elizabeth, alive in 1833, unmarried; 3. Catherine, who married J. B. Wilkinson; 4. Robert, who died without issue; 5. John. The William & Mary College Quarterly Historical Magazine (Vol. 5, No. 1 (July 1896) p. 148.
Catherine, who married in October 1784 (Bond 31 October 1784) Robert Boush, who died 15 October 1809; he was ensign and paymaster in Col. Dabney’s Virginia State Garrison Regiment. John Frederick Dorman, Adventurers of Purse and Person, 1607-1624/5 (Vol. II, Families G-P, 2004).
Margaret.
1. John Ballard Family Bible. See John Ballard of Yorktown, Virginia (1700-1745).
2. This lot 54 had been devised to Thomas Ballard, Robert’s eldest brother who died at sea in September 1747, as noted in the John Ballard Family Bible.
3. York Co. Va. Deed Book, 1755-63, p. 350.
4. York Co. Va. Deed Book, 1755-63, p. 447. Anne Ballard’s relinquishment of dower recorded 26 May 1762. York Co. Va. Deed Book, 1755-63, p. 449. Robert Ballard is mentioned as a former owner of a lot in Yorktown in one last transaction dated 10 May 1773, when “Thomas Lilly & Lucy his wife of York Town mariner for £85 sold to John Davis of sd town, York Co. all that lot or ½ acre of land the sd Thomas Lilly purchased of Robert Ballard of Princess Anne Co. being the lot devised the sd Robert Ballard by his father John Ballard decd.” York Co. Va. Deed Book, 1769-77, p. 308.
5. The Virginia Gazette, 8 November 1770, p. 3, col. 3.
One thought on “Robert Ballard of Princess Anne County, Virginia (1733-1770).”
[…] Note that there is no mention of Robert’s daughter Margaret, who must have been dead by 1785. For details on all of the above, please see John Ballard of Yorktown, Virginia (1700-1745) and Robert Ballard of Princess Anne County, Virginia (1733-1770). […]
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Third loaded firearm confiscated at Portland airport this year
Courtesy of the Transportation Security Administration
A Poland man was briefly detained on Tuesday afternoon when he allegedly brought a loaded handgun to a checkpoint at the Portland International Jetport, according to a Transportation Security Administration spokeswoman.
By Christopher Burns, BDN Staff • December 10, 2019 2:54 pm
The man, who was not identified, had a loaded 9 mm handgun tucked into the outer pocket of a black messenger bag when he attempted to pass through an airport checkpoint.
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A Poland man was detained Tuesday afternoon after he allegedly brought a loaded handgun into the Portland International Jetport.
The man, who was not identified, had a 9 mm handgun loaded with 12 bullets, including one in the chamber, tucked into the outer pocket of a black messenger bag when he attempted to pass through a checkpoint, according to Lisa Farbstein, a spokeswoman for the Transportation Security Administration.
A TSA official spotted the firearm when the man’s bag passed through a checkpoint X-ray machine, Farbstein said.
Airport security confiscated the firearm and detained the man for questioning, Farbstein said. He was later released and allowed to secure the firearm in his vehicle before returning to catch his flight, she said.
It was the third loaded firearm to be found going through the checkpoint at the Portland jetport. On Oct. 30, a Minot woman was caught with a loaded 9 mm handgun tucked into her purse. The next day, a Florida man was found with a loaded 9 mm handgun in his knapsack as he attempted to pass through the checkpoint.
In 2018, 4,239 firearms were discovered in carry-on bags at airport checkpoints across the country, up from 3,957 the year before, according to data provided by the TSA. Nearly 90 percent of those were loaded, while a third had a bullet in the chamber, according to TSA data.
Passengers are permitted to travel with firearms in checked baggage if they are unloaded, packed in a hard-sided case, locked and packed separately from ammunition. Anyone who brings an undeclared firearm through a checkpoint can face criminal charges and civil penalties up to $13,333, according to the TSA. A typical first offense for carrying a handgun into a checkpoint is $4,100.
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Byton is launching an app developer program for its M-Byte electric SUV
TechCrunch 6 January 2020
China-based electric car startup Byton might be best known for its massive 48-inch wraparound digital dashboard screen in its upcoming M-Byte SUV, as well as a host of other screens sprinkled throughout the vehicle. Those screens might get all the attention, but they are merely the delivery mechanism or "stage" for what Byton hopes will be a smart device on wheels.
The company announced Sunday ahead of CES, the annual tech trade show in Las Vegas, that it will launch a developer program to unlock the kinds of apps that will turn these screens into an interactive and valuable experience for customers.
Jeff Chung, Byton's VP of digital engineering, said the company has known from the outset that it would need to invite partners to "create truly compelling interactions."
"Byton's unique user interface offers developers a challenge and an opportunity to engage with an in-car experience like none they have ever seen," he added.
Byton has already been working with companies like Access, AccuWeather, Aiqudo, CloudCar, Road.Travel and Xperi to develop apps and services for entertainment, health and e-commerce. The developer program aims to expand that app ecosystem.
Byton has released UX design documentation as well as app development guidelines with the launch of the program.
CES 2020 coverage - TechCrunch
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Home News ‘Red Magic 5G’ to be Powered by Snapdragon 865, Confirms Nubia
‘Red Magic 5G’ to be Powered by Snapdragon 865, Confirms Nubia
Following the official unveiling of the Snapdragon 865 and 765 mobile platforms in Hawaii earlier this week, a whole host of smartphone vendors have announced plans to launch smartphones powered by the two SoCs. Nubia has now become the latest brand to jump on the Snapdragon 865 bandwagon by confirming that its next-generation gaming handset, the Red Magic 5G, will be based on Qualcomm’s newly-announced flagship chipset.
The announcement, which was made via the official Red Magic Weibo account on Wednesday, revealed precious little about the device itself other than claiming that it would be first dual-mode 5G gaming smartphone powered by the Snapdragon 865. The same platform will also very likely power the next-gen gaming smartphones from Asus (ROG Phone 3), Xiaomi (Black Shark 3) and Razer, so it will be interesting to see who will be the first one to launch a flagship gaming device with the new chipset.
Image Courtesy: Nubia (Via Weibo)
While we expect to start getting a few pieces of info about the upcoming device in the weeks ahead, we’re unlikely to get the full technical details any time soon. While the Red Magic 3 was launched in May this year, the Red magic 5G is likely to be launched a little earlier in 2020, but in the absence of an official ETA, we’ll have to wait a bit for more details on that.
In case you don’t know it already, Qualcomm on Tuesday announced its newest flagship mobile processing chipset, the Snapdragon 865, at the “Snapdragon Tech Summit 2019” in Hawaii, USA. It has already been confirmed to power a bunch of high-end smartphones next year, including the Mi 10 from Xiaomi. It will also power the 2020 flagships from several other manufacturers, including Oppo, Meizu and more.
SOURCENubia (Via Weibo)
Red Magic 5G
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Anti-Biofilm Technologies: Pathways to Product Development
This conference served as an excellent opportunity to address difficulties in the antimicrobial and infection prevention industries. Most notably, product development and testing required by the regulatory agencies were discussed, along with the lack of direction for marketing claims and FDA/EPA acceptance of anti-biofilm products. Additionally, the process of Pre-Submission through the FDA was outlined and further highlighted the challenges of getting products to market without adequate regulatory guidelines put in place.
Session 1: Medical Device Technologies
Bacterial Interactions with Ultra Soft Biomaterials Used in Medical Devices
K. Scott Phillips, Regulatory Research Scientist, Center for Devices & Radiological Health, US FDA
Skin injection and material colonization were assessed for dermal fillers (DF). Injection testing showed variability in bioburden and suggested that differences in techniques yielded inconsistency in infections. Skin preparation testing of 70% ethanol, chlorhexidine, and povidone iodine wipes showed performance differences based on both composition and texture. Increasing stiffness of DF reduced bacterial adhesion; however, stiffer materials created a niche for bacterial biofilm. Results may be used to develop guidelines for clinicians on how to reduce contamination and show that infection rates might be lowered with DF that can reduce bacterial adhesion but also self-seal.
Biofilm Initiation on Medical Devices
Philip S. Stewart, Professor, Chemical & Biological Engineering, Montana State University
Research described how biofilms initiate on a device and how an established biofilm persists amid host defenses and antimicrobial chemistry. Failure of an antimicrobial to fully penetrate the biofilm was observed. Mechanisms of biofilm tolerance depend on nutrient reduction within the biofilm leading to slow growth or dormancy and consequently, reduced susceptibility. This diffusion predicts thicker biofilms will become progressively more protected.
Clinical Perspectives on Microbial Biofilms and Medical Devices
Brittany Goldberg, MD, Medical Officer, Center for Devices & Radiological Health/Office of In Vitro Diagnostics and Radiological Health, Division of Microbiology Devices, US FDA
Four clinical cases were reviewed to evaluate medical device infections in which biofilms affect clinical management. The medical literature and treatment guidelines were reviewed for each case and the roles of diagnostics were presented in the context of current standards of care. The FDA Pre-Submission program was discussed in reference to regulatory considerations for expediting anti-biofilm device submissions.
Animal Models and Implant Associated Infections
Tom Schaer, VMD, Director, Preclinical Research Services, School of Veterinary Medicine, University of Pennsylvania
Animal models that center on implant associated infections were explained. Monitoring tissue concentrations of antibiotic compounds by means of sampling various tissue compartments from a joint model designed to study efficacy of intervention was found to be most effective.
Microbion: Process of Anti-Biofilm Drug Application Through FDA
Brett Baker, President & CEO, Microbion Corporation
The FDA Pre-Submission program is formatted as a formal request for feedback from the FDA to help guide product development and preparation. A Phase-1 clinical study on Microbion’s Bismuth Thiol (BT) topical gel was completed in 2011. This study, along with GLP toxicology studies supported a 2013 IND application with the FDA for a Phase-2 clinical trial to evaluate the safety and efficacy of BT gel for local treatment of post-surgical orthopedic device-related infections, in combination with surgery. In 2012, a long term GLP toxicology study was completed and supported future development of BT gel as a treatment for chronic wound infections. These evaluations, along with a recently completed topical clinical trial, were provided to the FDA for further guidance on generating an approval process for an anti-biofilm drug product.
Session 2: Surface Disinfection Technologies
Assessment of Biofilm on Dry Hospital Surfaces: Development of Model Test Systems
Karen Vickery, Associate Professor, Medicine and Health Sciences; Scientific Director, Surgical Infection Research Group, Macquarie University, New South Wales, Australia
Multiple antibiotic resistant organisms are often isolated from hospital environments. The persistence of these bacteria in the environment is due to their incorporation into biofilms contaminating dry hospital surfaces, which renders them tolerant to desiccation and cleaning procedures. Surfaces of a hospital were sampled and the presence of drug resistant bacteria incorporated into biofilms was determined using a combination of PCR, FISH, next-generation sequencing, confocal microscopy, and SEM. A model test system was developed that visually resembled clinical dry surface biofilms.
Real World Problems, Solutions and Regulations, an Industry Perspective
Elaine Black, Principal Regulatory Specialist, Ecolab
Biofilm formation has extensive implications in a variety of applications, ranging from industrial processes like oil drilling, paper production, and food processing, to medicine and dentistry. The challenges of biofilm detection and control were discussed with the use of case studies from these fields. An industry perspective of standard biofilm methodologies and performance standards for EPA regulation of biofilm control suggests that there is dissatisfaction with the lack of testing methods for anti-biofilm claims.
Use of the Single Tube Method to Evaluate the Efficacy of Disinfectants Against Pseudomonas Biofilm
Rebecca Pines, Biologist, Microbiology Laboratory Branch, Office of Pesticide Programs, US EPA
The EPA is considering the use of the ASTM Single Tube Method (ASTM E2871-13) as an efficacy method to support the registration of antimicrobial products with anti-biofilm claims. In 2014, a collaborative study was conducted to evaluate the method’s performance. This study yielded unexpected variability in log reduction values for the high-efficacy treatments. A splashguard was developed to reduce this variability and was utilized in additional 2015 collaborative testing, where bleach and a quaternary-ammonium product (at high and low level concentrations) were tested against a P. aeruginosa biofilm. The preliminary findings suggest this may be an acceptable route and the industry expectation is that the method may be approved by the agency within 2 to 4 years. Upon acceptance by the EPA, BioScience Laboratories, Inc. has the capability to meet our customer's testing needs.
Using Statistical Confidence and Power to Assess Performance Standards for Tests of Antimicrobials
Al Parker, CBE Bio-statistician; Assistant Research Professor, Mathematics, Montana State University
A performance standard (PS) for an antimicrobial test method defines an acceptable outcome for a product. The PS also specifies the number of tests that should be performed and the number of laboratories utilized for product evaluation. The specifications set by a PS can be evaluated by two statistical characteristics: the confidence level of the PS, which is the percentage of ineffective products that the PS correctly fails; and the power of the PS, which is the percentage of efficacious products that the PS correctly passes. This approach was recently applied to reset the PS for the use-dilution method required by US EPA for registration of surface disinfectants.
Anti-biofilm Technologies: A Regulatory Model Harmonized with the Product Development Pathway
Marc Rindal, Regulatory Microbiologist, Antimicrobials Division, Office of Pesticide Programs, US EPA
An update to the EPA’s current registration pathway for products making anti-biofilm efficacy claims was presented. The EPA is considering registration of antimicrobial pesticides including those products making efficacy claims against biofilm. The EPA’s framework for registering anti-biofilm products was highlighted. Performance standards and the role of test parameters will be explored, focusing on the specific data requirements and their relationship to test methodology and label claims. The EPA representative could not comment on a timeline.
Lighting the Way to Long-Lasting Biofilm Remediation—Photochemistry Meets Biology
Chuck Pettigrew, Principal Scientist, Procter & Gamble
P&G have developed a system for the photocatalyzed generation of aqueous chlorine dioxide. Photocatalysis allows for product application without build-up of high concentrations. Initial results suggest that ClO2 can disrupt biofilms, resulting in partial removal of the biofilm from the test surface. Future tests will seek to better understand the ability of photo-ClO2 to remove and/or kill biofilms. This research will hopefully initiate a dialogue with the EPA about biofilm removal claims versus efficacy claims.
To learn more, or to get started with your project, contact our experts by either using our Request a Quote form or email us at experts@biosciencelabs.com.
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By David John Chávez Posted on Jul 20, 2019 July 21, 2019
Review: Rude, crude ‘Book of Mormon’ also delights at Broadway San Jose
“The Book of Mormon” kicked off the early part of the decade as fierce satire, highly offensive, rude and crude. And years later, as the end of the decade is upon us, the show is still fun, fierce, irreverent, juvenile and sharp.
Broadway San Jose is the latest stop for the national tour of the nine-time Tony Award winner, which rang the nation’s doorbells back in 2011 for the first time. And while there are certainly plenty that might look at the show as a playground for a bunch of religion-hating Broadway creative heathens, what cannot be undone by anyone is the pure glee and joy that radiates through the cast and their impeccable performances.
The story kicks off at a Mormon Missionary Training Center, where the chipper young charges, armed with crisp, white shirts and pearly white teeth are ready to spread the word of Mormonism founder Joseph Smith. There are exotic, thrilling places throughout the world ready to welcome the young, white men whose only association with anything black is their super thin ties they seem to sleep in. The mean streets of Norway and Orlando await.
That Orlando dream is strong with Elder Price (a fantastic Liam Tobin), but it’s quickly snuffed out twice in one fell swoop. Not only is Price now bound for Uganda, but he is paired with the compulsive, geeky pipsqueak Elder Cunningham (Jacob-Ben Schmuel, he of impeccable comic timing). To make matters worse, Price is now bound with Cunningham to Rule 72 – they must stick together non-stop, with the occasional bathroom break being the exception.
Uganda is not initially kind to the two very green missionaries. Led by General Butt-Fu**ing Naked (a strong Corey Jones), their luggage is stolen, and the citizens have some strong, musical feelings about God, sung with a “Hakuna Matata,” spirit and an irony that is wildly infective. Their “Don’t worry” saying has a bit of a twist.
The people of Uganda are wonderful, hopeful but have been burned before, and have no interest in engaging more false promises on how God is going to save them from their brutal circumstances. And the missionaries are thoroughly discouraged by their inability to get someone, anyone to convert to Mormonism. After all, since 1978, the missionaries’ logic concludes, black people can now participate fully as Mormons, so what’s the delay?
There is one delightful young woman who dreams of the unicorns that await in Sal Tlay Ka Siti, and that is Nabulungi (a wonderful Alyah Chanelle Scott). It is her belief that it’s a real place, and with this joyous vision, she and Cunningham work together to convert the others, with hilarious and disastrous results. All this is done in front of her very skeptical father and village leader Mafala (a thunderously sharp Jacques C. Smith).
While there are certainly some things that push hard right up to the line, if not cross it altogether, the show, created by South Park creators Trey Parker and Matt Stone, solidified by master musician Robert Lopez, remains as sharp satire. The show sharply lampoons the ignorance and perceptions of those coming from a colonial diaspora thinking that everyone else has problems.
Lopez’ music and songs are still fantastic. Numbers like the opening number “Hello,” and others such as “All American Prophet,” “Turn it Off,” featuring scene stealer Andy Huntington Jones as Elder McKinley, and the Elder Cunningham opus “Man Up” are all full of big Broadway stylings. Lopez does not hesitate to dot his numbers full of delightful send ups and touchstones of many Broadway hits.
And Casey Nicholaw, who has been positively killing in the choreo game for years, is wonderful here as the audience returns to some of his earlier Broadway work.
The show’s vulgarity and problematic tropes are not going to be for everyone. But if you find Cartman, Kyle, Stan and Kenny hilarious, this show might be for you.
WHAT TO KNOW IF YOU GO
Broadway San Jose presents “The Book of Mormon”
Book, music and lyrics by Trey Parker, Matt Stone and Robert Lopez
Choreographed by Casey Nicholaw
Directed by Casey Nicholaw and Trey Parker
The Word: A show not for everyone, but one that still shows some sharp satirical bite.
Stars: 4.5 out of 5
Broadway San Jose
San Jose Center for the Performing Arts
255 S. Almaden Blvd., San Jose, CA 95113
Through July 21st
Tickets range from $43 – $228
For tickets, (800) 982-2787 or visit https://broadwaysanjose.com/
Categories: UncategorizedTags: Book of Mormon, Broadway San Jose, Casey Nicholaw, Matt Stone, Robert Lopez, San Jose, Trey Parker
Published by David John Chávez
View all posts by David John Chávez
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Build a PC Python for Java Programmers
The Grand Tour is great so far
526 words, a 3 minutes read
So yesterday the first episode of The Grand Tour (GT) has premiered. Why is that so important? GT is sort of the successor to Top Gear (TG). Why is that?
In 2015, near the end of series 22, it became public that Jeremy Clarkson had punched a producer for not serving the hosts warm dinner. He was then fired (or technically, his contract wasn’t renewed) and the show was taken over by Chris Evans who then did another series this year with almost no one watching it.
Hammond and May left with Clarkson of course and the three were then approached by the new big ones: Netflix and Amazon (Prime). And Amazon Prime won them for at least 3 seasons as for now. The season airs in 12 episodes and it’s a new episode each Sunday (no binge-watching sadly).
Sidenote: Amazon has just announced they’re going to expand worldwide by December. They’re going in big with this one.
Now yesterday we could actually see what that brought us. And it’s great. Let me start with a quote from the Telegraph:
Somewhere out there you could almost hear Chris Evans locking his bedroom door from the inside and sobbing.
First of all, the three are just the same. Snickering about, leaving each other behind, unfair challenges and so on. That’s what killed Top Gear and that’s what Chris Evans will never understand. Top Gear is as much about cars as Michael Schumacher is the Stig (he isn’t). Most of all, it’s three blokes doing what all blokes would if they could.
There are a few differences from GT to TG. The BBC has ordered Clarkson not to use some of his keywords, so there’s no “On that bombshell” and “some say”. And the Stig is apparently trademarked.
First of all, there’s no studio anymore. They’re travelling around the world in a tent, so this episode they were somewhere in the USA, next episode’s stop is Johannesburg.
They’ve built a new track in England, mostly consisting of the Isn’t-Straight (cause it isn’t straight) and hired a new test driver who had to be American. I don’t like him yet but let’s see what’s to come. TG series 1 had no James May, so there may still be some changes.
The Reasonably Priced Car is gone and replaced by a new celebrity feature which they didn’t show properly in the first episode, you’ll see why.
The first episode is called “The Holy Trinity”. No, it’s not the three blokes. It’s about stuff they promised on Top Gear but was never shown. Let me just say hypercars and that will be it, you’ll have to see it.
For comparison, I watched the last episode of proper Top Gear first, where there’s just May and Hammond left. I hadn’t watched that yet because it was said to be too sad, so I waited until the new series. Let’s just say, GT starts where TG ends.
So you can fairly say that The Grand Tour is the successor to Top Gear. I wonder how long they’re gonna let that corpse lie around before they scrap it, but we now have something better.
Lukas Röllin Dev & IT Security Guy
Movie makers: get your shit together
Chester Bennington has died
YouTube annotations are gone for good
If you make a series, link to the other parts
Google AMP: Get to the original site
Motorsport Reporters: Don't talk over the radio!
RNS 510: AUX doesn't work (suddenly)
C arrays are just better pointers
System Administration UX needs to improve
Splinter Cell: Blacklist not launching
© Copyright 2018 Lukas Röllin | Built with Hugo
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Libri Libri 1 - 10 di 142 su Improvement, and Management of Landed Property, and the Cultivation and Economy of....
Improvement, and Management of Landed Property, and the Cultivation and Economy of the Animal and Vegetable Productions of Agriculture, including all the latest Improvements. A general History of Agriculture in all Countries, and a Statistical View of...
The Gardener's Magazine and Register of Rural & Domestic Improvement - Pagina 234
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The Edinburgh Review: Or Critical Journal, Volume 92
...Engravings. 23. New and much Improved Edition of London's Encyclopaedia of Gardening, in Ten Monthly Parts. An Encyclopedia of Gardening ; Comprising the Theory...Statistical View of its Present State : with Suggestions for it» Future Progress in the British Isles. By JC Loudon, FLSHS &c. In One large Volume, 8vo. illustrated...
Sydney Smith, Lord Francis Jeffrey Jeffrey, Macvey Napier, Sir George Cornewall Lewis, William Empson, Henry Reeve, Arthur Ralph Douglas Elliot (Hon.), Harold Cox - 1831
...agricultural science and practice will admit. AN ENCYCLOP/EDIA OF GARDENING ; Comprising the Theory end Practice of Horticulture, Floriculture. Arboriculture,...Statistical View of its Present State, with Suggestions fur its Future Progress In the British Isles. Illustrated with upwards of 700 Engravings on Wood. Complete...
Sydney Smith, Lord Francis Jeffrey Jeffrey, William Empson, Macvey Napier, Sir George Cornewall Lewis, Henry Reeve, Arthur Ralph Douglas Elliot (Hon.), Harold Cox - 1827
...Vegetable prodnctiuns of Agriculture, including the latest Improvements; a gene. ral History of Agriculture in all Countries ; and a Statistical View of its present...Suggestions for its future Progress in the British Isles. By JC LOLDON. FLS HS, &c. In 1 large Vol. hvo. closelyprinted, with upwards of 800 Engravings...
Sydney Smith, Lord Francis Jeffrey Jeffrey, Macvey Napier, Henry Reeve, William Empson, Sir George Cornewall Lewis, Arthur Ralph Douglas Elliot (Hon.), Harold Cox - 1828
...Vrgvtable Productions of Agriculture, including the latest Improvement* ; a general History of Agriculture In all Countries; and a Statistical View of its present State, with Suggestions for iu future Progress in the British Isles. In 1 large Vol. BTO. closely printed, with upwards of 800...
Sydney Smith, Lord Francis Jeffrey Jeffrey, Macvey Napier, Arthur Ralph Douglas Elliot (Hon.), William Empson, Sir George Cornewall Lewis, Henry Reeve, Harold Cox - 1827
...Vegetable Production} of Agriculture, including tht latat Improvements ; A GENERAL HISTORY OF AGRICULTURE IN ALL COUNTRIES; AND A STATISTICAL VIEW OF ITS PRESENT STATE, WITH SUGGESTIONS POR ITS FDTCBE PROGRESS IN THE BRITISH ISLES. BY JC LOUDON, FLSHS &c. Alia, by the lame Author, Complete...
...comprising the Theory and Practice of Horticulture, Floriculture, Arboriculture, and Landscape-Gardening ; including 'all the Latest Improvements, a General...and a Statistical View of its Present State, with Sug. gestions for it* Future Progress, in the I '.i! n-.ii Isles. By JC Loudon, FLS H. 8. &C. author...
...Vegetable Productions of Agriculture, including the latest Improvement* ; a General History of Agriculture in all countries ; and a Statistical View of its present...Suggestions for its future Progress in the British Isles. By JC London, FLSHS &c. 8vo, Engravings, L.2, 10s. An Easay on the Weeds of Agriculture, with...
Newton's London Journal of Arts and Sciences: Being Record of the ..., Volume 4
William Newton, Charles Frederick Partington - 1822
...and assiduity of MrMyers, and is a "valuable accession to our national literature. An Encyclopaedia of Gardening, comprising the Theory, and Practice...suggestions for its future progress, in the British Isles. By JC LODDON. Illustrated with nearly six hundred engravings on wood* 8vo. pp. 1488. THIS is...
The London journal of arts and sciences (and repertory of patent ..., Volume 4
William Newton - 1822
...assiduity of MrMyers, and is a valuable accession to oar national literature. An Encyclopedia ofGardening, comprising the Theory, and Practice of Horticulture,...suggestions for its future progress, in the British Isles. By JC LOUDON. Illustrated with nearly six hundred engravings on wood. 8vo. pp. 1488. THIS is...
The London Journal of Arts and Sciences, Volume 4
...assiduity of MrMyers, and is a valuable accession to our national literature. An Encyclopedia ofGardening, comprising the Theory, and Practice of Horticulture,...suggestions for its future progress, in the British hies. By JC LOUDON. Illustrated with nearly six hundred engravings on wood. 8vo. pp. 1488. s THIS is...
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Buy The Universe Will Provide (2014) CD Here!
Or download from iTunes or CD Baby
Preview the album here
Category: Uncategorised Tags: 2014, album, music
Bosko & Honey have come of age with their gutsy new release, “The Universe Will Provide”.
This 48 minute album contains 14 original songs highlighting Bosko & Honey’s trademark playfulness and musicality, but also merging with deeper themes exploring hidden meaning, pathos and irony… yet somehow always maintaining a sense of genuine humanism. Seriously multi-genre, this album can be put on loop and listened to for hours… each song as surprising and delightful as the last. “The Universe Will Provide” is the must-hear ukulele album of the year, if not the decade.
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Boston Classical Review
New York Classical Review
South Florida Classical Review
Texas Classical Review
Utah Arts Review
Washington Classical Review
The Classical Review
A notable BSO debut set against Haitink’s mellow mastery
By Lawrence A. Johnson
Till Fellner performing Mozart's Piano Concerto No. 22 with Bernard Haitink and the BSO Thursday night at Symphony Hall. Photo: Stu Rosner
In the central installment of his season-ending three-week stand with the Boston Symphony Orchestra, Bernard Haitink served up two of his favored composers, framing an impressive BSO debut by pianist Till Fellner Thursday evening at Symphony Hall.
The Austrian pianist, 40, has carved out a high-profile international career over the last decade and is particularly esteemed for his Beethoven, having performed the composer’s complete sonatas last season in New York, London and Vienna. Fellner proved an equally rewarding Mozartian in his BSO bow Thursday night in the Piano Concerto No. 22 in E flat, K.482.
The E-flat concerto calls for the largest orchestra of all Mozart’s works in the genre with pairs of horns, trumpets, clarinets, bassoons, flute and timpani. Yet, as solo protagonist, Fellner maintained his place in the spotlight, finding an illuminating middle ground between polished elegance and dynamic vigor. The pianist brought an individual rubato to Paul Badura-Skoda’s first-movement cadenza (none by Mozart survive) and in the bleak introspection of the Andante, Fellner’s pointillist shading explored the dark drama of the music without inflating it out of period.
The closing Allegro with its skipping child-song-like main theme was thrown off with a playful touch in Fellner’s lightly sprung style. The soloist eased into the aria-like contrasting motif with heartfelt warmth, threw in some dazzling bravura with Hummel’s slightly anachronistic cadenza, and rounded off the performance with the requisite ebullient charm.
Haitink’s big-boned accompaniment was alert to his soloist if fitfully out of synch with Fellner dynamically. The grandly spun orchestral playing seemed to be looking forward to the Romantic era down the road, while Fellner’s poised Classicism kept firmly within Rococo parameters.
Prelude to the Afternoon of a Faun has long held an elevated place in the BSO tradition, with Debussy’s evocative tone poem well served throughout the past century by this most Gallic of American orchestras under conductors such as Monteux, Munch, Ansermet and Ozawa.
Haitink’s objective lucidity has always been well suited to Debussy and so it proved again Thursday night. The Dutch conductor’s spacious direction allowed the hazy, evanescent textures to move with a kind of atmospheric inevitability, yet with sinew beneath the pellucid surface. Elizabeth Rowe’s flute solos sensitively conveyed the arboreal languor as did Malcolm Lowe’s silken violin playing. Too bad about the unmuffled bronchial outbursts that repeatedly intruded upon the performance.
Beethoven figures in all three of Haitink’s spring BSO programs, with the Ninth Symphony closing the season next week and the Symphony No. 6 presented Thursday night.
The approach of the orchestra’s conductor emeritus in Beethoven is fleeter and lighter on its feet than in decades past, largely to worthy effect.
Still, Haitink’s Beethoven has always been most effective in the cut-and-thrust drama of the odd-numbered symphonies rather than the lighter expression of the even-numbered works. For all his justly celebrated qualities, impish whimsy is not in Haitink’s portfolio and there were moments in this Pastoral symphony—the ‘Scene by the Brook,” the village band’s toneless wind piper—when the conductor’s sobriety of approach seemed to stint on the charm and humor at its heart.
Yet this was such a vital, magnificently played and otherwise vividly characterized performance that all doubts were swept aside. Haitink’s mastery in eliciting meticulous balancing and transparency allowed the BSO players to shine gloriously. There were numerous felicities, from Lowe’s zephyr-like trills in the second movement to the ensuing, wonderfully bucolic woodwinds to the double-basses’ ominously approaching, exploding and receding thunder. In the storm section Haitink and the BSO whipped up a cataclysmic tempest and the beneficent finale was rendered with just the right luminous nobility in Beethoven’s glowing pantheistic coda.
The program will be repeated 1:30 p.m. Friday and 8 p.m. Saturday. bso.org; 617-266-1200.
Posted in Performances
©2020 Boston Classical Review. All rights reserved. Contact Editor Lawrence A. Johnson at ljohnson@theclassicalreview.com. Subscribe via RSS.
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Friends season 11 free torrent download. FRIENDS
Friends season 11 free torrent download Rating: 6,9/10 250 reviews
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The first episode of the Comedy, Family, series was released in 2007-09-17 by Public Broadcasting Service. Disclaimer: SockShare is absolutely legal and contain only links to other sites on the Internet : dailymotion. Please seed so others can enjoy without the need to download and converted 10 separate series. A struggling novelist and a young waitress strike up an extramarital relationship that promises to forever change the course of their lives. However, consummating the relationship becomes disastrous, and they decide to remain friends. We will update this page with direct download links and complete tv packs. After several script rewrites and changes, including a title change to Six of One and Friends Like Us, the series was finally named Friends.
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In an attempt to start a new life after running out on her wedding, she shares an apartment with an old best friend Monica Gellar, and eventually befriends the other 4 and Monica's older brother, Ross. . Main Cast Friends cast from left to right, as , as , as , as , as and as. With an starring , , , , and , the show revolves around six 20-30 something friends living in. Monica decides to get rid of her poofy hair by getting corn rows. Ross Gellar - Older Brother of Monica, he has always had strong love feelings for Rachel.
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All ten seasons of Friends ranked within the top ten of the final ratings; ultimately reaching the No. Enjoy, and please let me know if you have any problems. Phoebe is masseuse, but enjoys playing guitar and also writes her own songs, which are a bit odd. Ross hopes to obtain a research grant from Benjamin Hobart, who happens to be Charlie Wheeler's ex-boyfriend. Monica Gellar - A compulsive neat freak, who has trouble with her love life. Charlie realizes that she is still in love with Benjamin and returns to him. Together they all are just friends.
If you have any legal issues please contact the appropriate media file owners or host sites. The original executive producers were , , and. We do not host or upload any video, films, media files avi, mov, flv, mpg, mpeg, divx, dvd rip, mp3, mp4, torrent, ipod, psp , SockShare is not responsible for the accuracy, compliance, copyright, legality, decency, or any other aspect of the content of other linked sites. The on May 6, 2004, was watched by around 52. On the plane home, Ross tells Joey about him and Charlie, but Joey doesn't tell Ross about him and Rachel.
Monica was teased when she was in high school for being overweight. Back in New York, Ross walks in on Rachel and Joey kissing. The series was produced by , in association with. Friends received acclaim throughout its run, becoming one of the most popular television shows of all time. The episodes i have watched so far namely season 2 seem to be the extended versions, i don't know if the rest are as i haven't got that far, if people find ones that aren't and know of a place where i can get ones that are, i'd be happy to edit this to include them. Friends Season 1 1994 Summary Friends Season 1: A Comedy Series based in Manhatten about 6 young friends, in the struggle to find success and happiness in life, but it is never that straight forward, is it? Joey and Rachel try to contend with Ross's feelings about them being together. Rachel Green - A popular schoolgirl of the past, is now a spoiled brat living off her fathers finance.
The series was nominated for 62 , winning the award in 2002 for its eighth season. Each episode is about 150-250mb in size. However, now a head-chef at a top restaurant in Manhatten, she has lost all her excessive weight, and just wants to start a family with 'the right guy' to complete a happy life. Kauffman and Crane began developing Friends under the title Insomnia Cafe between November and December 1993. Both couples put their relationships on hold while they wait to talk to the other before proceeding. I have a fibre connection so i will seed as long as i need to.
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The series, which first aired on April 6, 1992, features the title character Barney, a purple anthropomorphic Tyrannosaurus rex who conveys educational messages through songs and small dance routines with a friendly, optimistic attitude. Actors in the cast include David Joyner, Carey Stinson, Dean Wendt, Julie Johnson, Jeff Ayers, Patty Wirtz, Michaela Dietz, Bob West, Adrianne Kangas, Tory Green, Emilio Mazur, Kyle Nelson, Lauren Mayeux, Jerad Harris. Copyright © 2017 SockShare, All rights reserved. A successful professor of science leads him to be often teased by the other 5 friends about his profession. S01E01 Episode 1: The One Where Monica Gets a Roommate 1 008. Three young women and three young men in one small and beautiful Manhattan.
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Monica, Chandler and Phoebe find out that they can hear through the walls in their hotel rooms. Monica and Chandler cover the wall where they can hear Joey and Rachel kissing, and Phoebe covers the wall where Charlie and Ross are kissing. . . . .
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SEA EAGLE BOATER RESCUES HIS LITTLE DOG FROM A BIG, BIG LAKE — Lake Ontario Adventure
David Anderson and his miniature schnauzer, Jack, in his Sea Eagle 330 sport kayak on the Canadian side of Lake Ontario.
It’s one of those funny stories the family laughs about around the dinner table but a tragedy was averted when a small dog started swimming after his master in a very large lake.
David Anderson lives near Toronto, Canada, and is an avid Sea Eagle boater. “I go out boating pretty much every weekend,” David told us, “especially since I live very close to Lake Ontario.” The smallest of the Great Lakes, Lake Ontario is BIG — 7,540 square miles — almost as big as the state of New Jersey. It’s an outstanding area for boating and fishing, but can be big trouble for a little dog that tops out at about 15 lbs.
David and his dad set out for a pleasant paddle in their Sea Eagle 330. Little did they know theyd soon be on a rescue mission!
Last summer, David and his dad inflated David’s Sea Eagle 330 and went out for a paddle while David’s mom, Elizabeth, stayed on shore.
Elizabeth tells the story. “My husband and David launched the 330 while I held David’s miniature schnauzer, Jack, on a leash on shore. Suddenly, Jack broke away and started swimming out toward the kayak. I was yelling, of course, and my son and his dad turned the kayak around and came back and rescued the dog. It all turned out very well. We all love the kayak, including the dog.”
David told us, “Any time I leave Jack, he freaks out. He went off his nut, got away from his leash, and swam out to follow me. We were able to pick him up and brought him back to shore safely.”
Dog on board
There’s an even happier ending: David now takes Jack with him in his Sea Eagle. “He was very nervous at first but now is quite comfortable on board. And I like having him on the boat with me.”
David’s not alone in combining his love of boating and dogs. One of the most frequently asked questions Sea Eagle buyers ask is, “Can I put my dog in a Sea Eagle?” And our answer is, “Yes. All Sea Eagle boats are tough enough to accommodate your pet.” See this and more FAQ’s on the Sea Eagle website, www.SeaEagle.com.
Swan rescue, too
David seems to have a knack for rescuing animals in trouble while boating. He tells us that while boating on the Credit River in his Sea Eagle 330, “I saw a fisherman on the shore doing something with a swan. He signaled me and I paddled over. The swan had a rope wrapped around his wing.”
Swans are big birds that can weigh up to 33 lbs. and can have a wingspan of nearly 10 feet. They can also be decidedly unfriendly, particularly when one is trying to remove a rope they’re tangled in. “I held him by his little pink feet while the fisherman cut the rope away,” says David. The swan paddled away — shaken but free.
Boat racing & cardiovascular exercise
David and his family have a rich boating history. “My whole family was involved in boat racing,” he tell us. “We raced kayaks and canoes in regattas throughout the Canadian provinces.” David says there are regatta plaques and trophies all around the family home.
These days, boating’s part of David’s fitness training program that includes weightlifting and bodybuilding. “I’ve been involved in sports all my life — karate, hockey, football, soccer, and lacrosse,” he tells us. “Kayaking in the Sea Eagle provides a cardiovascular component.”
When not working out, David’s working in marketing for CBS Outdoor Media. And he’s making plans for some outdoor adventures of his own – a kayaking and camping trip to Algonquin Park, Central Ontario’s famous provincial park that features over 2,400 lakes and almost 750 miles of rivers and streams.
Packs small, “cooks” through waves
When we asked David what he might tell someone who’s thinking about a Sea Eagle, he had some very practical advice. “I was looking at hard-hull kayaks, but for an apartment dweller like me, the Sea Eagle’s perfect. It rolls up small and stores easily in my back room.”
David & Jack, happy after their adventure in Lake Ontario.
What about performance? “It cooks through the waves,” he said. “I’d tell people who’re interested to purchase one for the convenience alone. It’s light and very durable. It can carry up to 500 lbs., can go anywhere including rough waters. I endorse it 100%.”
Our guess is that Jack the miniature schnauzer does, too.
Do YOU have Sea Eagle photos and stories to share? Our blog visitors want to know!
E-mail us today.
April 27, 2011 May 23, 2018 Cecil Hoge
3 thoughts on “SEA EAGLE BOATER RESCUES HIS LITTLE DOG FROM A BIG, BIG LAKE — Lake Ontario Adventure”
Hernan says:
Great story, I’m one of those who are afraid of boating in the event that my kayak flips over with the waves or I get drifted away by the winds etc. Any sharing of experience with the sea eagle is helpful I am ready to face my fears this coming summer Thanks.
Keep at Heman! You WILL get the hang of it and before you know it you will be cooking through the waves! Like anything you are not used to.. you will adapt.
Take care, good luck,
and Be safe.
Lots of neat stories here. We hang out on the Suwannee River between the gulf and the Santa Fe river. We love long distant riding on our waverunners. We occasionally take the boat and go fishing but we are not good fishermen at all. Some very nice fish here.
Previous Previous post: “WE HAVE OUR OWN SEA EAGLE NAVY!” — 6 couples, 6 Sea Eagle Sport Runabouts
Next Next post: A Sea Eagle among SOUTH CAROLINA’S BARRIER ISLANDS
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Thoughts on the Napa 2014 Quake
By now you've heard of the 6.0 Napa Quake in August costing businesses there a conservative $80,000,000. It's probably a lot more. Firstly, let me just say to all those idiots out there who keep saying 6.0 ain't no thing: It is. I grew up in LA and went to school in The Bay, and I will tell you, a 6.0 is major. Half the structural damage you won't notice for years, and you're lucky to have lived through it. And if you're a collector of little glass figurines, and you've put thousands of dollars and years of your time into the collection, imagine how you'd feel picking up its shards. Now imagine if that was a massive cellar of aging wine you'd planned on selling as part of an investment strategy for your business, or worse, retirement.
But that's not even the worst of it. You might have harvested and crushed and aged for a year. You were about to bottle to make room in barrels for an October harvest. Too bad; you just lost your 2013 batch. And if you'd already started on your 2014, tough break, kid.
And all of that is why I think Napa wines will be 15-30% more costly from 2013, 2014, and maybe even 2015. And that is probably mostly going to be on the shelves because wineries have already maxed out what they can charge tourists in Napa (they've been fleecing visitors more and more each year).
On another note, I hope there will be a cool factor associated with 2014, maybe even collector's edition bottles commemorating the great quake. I personally would like to have a few bottles in my cellar like that, break 'em out at parties and have a story to tell.
But here't the other thing: If I were a winery in Oregon, Washington, New York, Virginia, or maybe even France or Argentina, I would DROP my prices ever-so-slightly. No one is taking down Cali any time soon, but I do think there is some brand development opportunity available to anyone willing to make a go of it next year. "Hey Napa's expensive this year, but check out this similar quality Cab from XYZ. It's usually more expensive than Napa, but they've actually lowered their price this year, and now they're CHEAPER than the Napa label." That's the pitch. EASY!
But I really do feel for the citizens of Napa and to anyone who loves Napa wine. It's a tragedy, it really is.
Labels: america, beverage, bottles, california, napa, tragedy, Travel, virginia, Wine
I love Napa Valley wines! I wish they'd make a sequel of Sideways. What do you think a bottle of a decent Napa P.N. will cost in 2015?
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David vs Goliath: how a small molecule can defeat asthma attacks
June 12, 2018 June 12, 2018 Ana Rodríguez 1 Comment asthma, PM-43I, Research, small molecule, STAT6
An invisible particle enters your lungs. The next thing you know breathing becomes difficult. You are having an asthma attack. Asthma is one of the most common and difficult to endure chronic conditions. About 30 million Americans experience asthma attacks and 3 million have a severe, therapy-resistant form of the disease. In some cases, the condition can be fatal.
“Despite the prevalence of asthma around the world, therapy for this condition has not significantly changed, with a few exceptions, in the last 70 to 80 years,” said Dr. David Corry, professor of medicine-immunology, allergy and rheumatology at Baylor College of Medicine. “For the most part, we are still treating the symptoms of the disease, not the underlying causes. In this work we present a novel new way to target a pathway we think is at the core of this allergic condition.”
Dr. David Corry
Current treatments attempt to relieve typical asthma symptoms, namely the constriction of the airways so patients can breathe easily. Treatments may also include steroids to shut down the inflammation that scientists have thought for many decades underlies airway constriction. Inflammation of the airway leads to shortness of breath, and that can make people panic and head to the emergency room.
Corry’s laboratory has been studying asthma for about 20 years. One of their interests is to better understand the molecular pathways that drive airway constriction.
The makings of an asthma attack
An asthma attack is anything but a simple event. It begins when environmental factors – allergens – enter the lungs and activate a chain reaction of molecular pathways that set off the development of the disease. Allergens activate immune cells, recruiting them to the lungs and leading some of them to produce a strong IgE antibody response and others to secrete immune mediators called cytokines. Cytokines IL-4 and IL-13 in particular are required for asthma to happen. These cytokines activate another molecule, transcription factor STAT6, that drives the expression of a number of genes ultimately leading to the exaggerated contraction of the airways that causes the much feared shortness of breath.
Mice that are genetically engineered to lack STAT6, also lack the responses triggered by the IL-4/IL-13/STAT6 interaction and are completely resistant to asthma attacks.
“STAT6 is at the epicenter of the immune responses that mediate asthma, so we looked for a means to block STAT6 activation,” said Dr. J. Morgan Knight, post-doctoral fellow in the Corry lab. “To activate STAT6, IL-4 and IL-13 bind to their corresponding receptors on immune cells. These receptors share a critical subunit called IL4R-alpha that activates STAT6. However, additional research from our lab has shown that completely different receptors also can activate STAT6. So, we focused our efforts on developing a small-molecule that would bind to and inhibit STAT6 activity directly.”
David defeats Goliath
Such efforts are no small feat. Corry, Knight and their colleagues had to design a small molecule capable of specifically targeting STAT6, which is inside the cells of the lungs, without also triggering unwanted side effects.
“After years of work, we succeeded,” said Knight. “We chemically synthesized a small molecule called PM-43I that can inhibit STAT6-dependent allergic airway disease in mice. Moreover, PM-43I reversed preexisting allergic airway disease in mice with a minimum dose of 0.25 μg/kg. Importantly, PM-43I was efficiently cleared through the kidneys and had no long-term toxicity.”
We concluded that PM-43I represents the first of a class of small molecules that may be suitable for further clinical development as a therapeutic drug against asthma,” Knight said.
Dr. J. Morgan Knight
One major advantage of developing PM-43I as an asthma drug that specifically targets a path that is required for the disease is that people probably would not need steroid treatments at the same time, which is what current asthma medications sometimes are paired with. Steroids shut down inflammation, but also other immune responses, such as the body’s ability to fight an infection. The researchers’ work shows that in fact treatment with their small molecule can control the asthma without impairing the mice’s ability to fight pathogens.
“This is important because there is a higher incidence of pneumonia in people with asthma, presumably because of the steroids they take,” Corry said. “Steroids drive down all the immune system, but our small molecule specifically targets the pathway that leads to asthma, uncompromising the other pathways that allow the body to fight disease. We anticipate that patients treated with our small molecule would not need steroids as our treatment alone would be able to control the asthma. Consequently, these patients’ ability to fight infections would not be affected.”
Although other groups have developed monoclonal antibodies that effectively target IL4R-alpha and inhibit STAT6-dependent allergic disease, and these antibodies are close to be approved by the Food and Drug Administration, the researchers think that their small-molecule approach offers unique advantages when compared with the much larger antibodies.
Formula of the small molecule PM-43I. Courtesy of Dr. D. Corry.
“We think that our small molecule offers the option of being easier to make and less expensive than the monoclonal antibody approach,” Corry said. “Also, people might develop sensitivity or tolerance to the monoclonal antibody treatment. On the other hand, our compound is a chemically synthesized very small molecule, so we think there is a smaller chance that people would develop a sensitivity to it. In addition, we think that our small molecule is better able to block STAT6 than the antibodies.”
“I am most excited about the potential to really affect disease,” Knight said. “I think that if our small molecule approach can help the lung resolve the chronic inflammation that is driving the asthma attacks, it might be possible to also resolve their condition.”
“The ideal way to manage any disorder is to get at the root, the fundamental underlying cause. In asthma, we can break it down into endogenous factors, in this case inflammatory, where STAT6 comes in, and then the environmental, and that is the nearly invisible particles,” Corry said. “Ideally, we would target both of these at the same time.”
This is our first shot at applying a modern understanding of disease to therapy. That’s what I am most excited about, developing a modern approach to treat this common disorder,” Corry said.
The researchers are working toward moving this small molecule to the next stage of testing in clinical trials in order to one day make it available to people.
Read all the details of this work in the Journal of Biological Chemistry.
Other contributors to this work include Pijus Mandal, Pietro Morlacchi, Garbo Mak, Evan Li, Matthew Madison, Cameron Landers, Brandon Saxton, Ed Felix, Brian Gilbert, Joel Sederstrom, Atul Varadhachary, Melissa M. Singh, Dev Chatterjee and John S. McMurray. The authors are affiliated with one or more of the following institutions: Baylor College of Medicine, MD Anderson Cancer Center, Michael E. DeBakey VA Center for Translational Research in Inflammatory Diseases and Fannin Innovation Studio and Atrapos Therapeutics, LLC.
Financial support for this project was provided by United States National Institutes of Health grants R41AI25007, R01 HL117181, Veterans Affairs Office of Research and Development grants I01BX002221 and I01 CX001673, the American Asthma Foundation and the Biology of Inflammation Center at Baylor College of Medicine.
J.M. Knight, P. Mandal, P. Morlacchi, D.B. Corry and Atrapos Therapeutics, LLC hold intellectual property rights in compound PM-43I.
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One thought on “David vs Goliath: how a small molecule can defeat asthma attacks”
Pingback:Defeating asthma attacks by going small - Innovation Toronto
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POLICE INTEGRITY LOST
Henry A. Wallace Police Crime Database has been updated
The Henry A. Wallace Police Crime Database was recently updated with changes to 787 cases. The current database version is v.052018.1238. Most of the updates involve reduction in missing data to one or more variables in a case (often related to criminal case dispositions and/or final adverse employment outcomes). The database currently includes information on 9,088 criminal arrest cases from the years 2005-2013 involving 7,518 individual nonfederal sworn law enforcement officers, each of whom were charged with one or more crimes. The arrested officers were employed by 3,140 state, local, and special law enforcement agencies located in 1,402 counties and independent cities in all 50 states and the District of Columbia. The next scheduled update to the database will include the addition of more than 1,000 arrest cases from year 2014 to be added prior to the end of December 2018.
Written by Phil Stinson
Posted in Henry A. Wallace Police Crime Database,Police Crime
Police Integrity Lost: A Longitudinal Study of Nonfederal Sworn Law Enforcement Officers Arrested Across the United States
Support was provided by the Wallace Action Fund of Tides Foundation, on the recommendation of Mr. Randall Wallace.
This project was previously supported by Award No. 2011-IJ-CX-0024, awarded by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice. The opinions, findings, and conclusions or recommendations expressed in this blog are those of the author(s) and do not necessarily reflect those of the Department of Justice.
Goals of the Research Project
There are three major goals of the project. The first goal of this research is to determine the nature and extent of police crime in the United States. The second goal is to determine what factors influence how a police organization responds to arrests of officers. The third and final goal of the research is to foster police integrity by exploring whether police crime and officer arrests correlate with other forms of police misconduct.
Philip Stinson, J.D., Ph.D.
Criminal Justice Program
E-Mail: stinspm@bgsu.edu
Twitter: @philstinson
Website: www.bgsu.edu/policeintegritylost
The Henry A. Wallace Police Crime Database Now Includes 2014 Arrest Cases
Police Crime Database Updated to include Officers Arrested in Year 2013
The Henry A. Wallace Police Crime Database now available online
Episode 42 of Police Integrity Lost Podcast Available on iTunes
Updated Count: Only 30 Police Officers in U.S. Convicted in On-Duty Fatal Shooting Cases since 2005
Stinson’s 2005-2011 Police Crime Data Set now available at ICPSR
82 Police Officers in United States Charged with Murder or Manslaughter resulting from On-Duty Shootings since 2005
BGSU researchers release report on police crime, schedule webinar to discuss findings
Officers Charged with an On-Duty Murder or Manslaughter where No Gun was involved
Police Crime
Crime by Policewomen
Drug-related Police Corruption
Guns / Firearms
Henry A. Wallace Police Crime Database
Late-Stage Police Crime
Off-Duty Police Crime
On-Duty Fatal Police Shootings
Police DUI Arrests
Police Integrity Lost Podcast
Police Sexual Misconduct Arrests
Police TASER Misconduct
Rates of Police Crime
Victims of Police Crime
Police Crime Database
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← Another sign you’re playing quality ball
Burn, baby, burn →
November 15, 2018 · 6:34 AM
“It would be a fun embrace of Cinderella for a sport that hates Cinderella.”
Dan Wetzel is rooting for Georgia to run the table through the SEC Championship Game. That’s not because he’s a huge fan of the Dawgs. They’re just a means to an end he’s been jonesing for.
One of the things that can change that thinking is when enough of college football is repeatedly left out of the playoff, rendering even historic, so-called Power Five conferences to second-tier status. Many believe the 2012 BCS title game featuring two SEC schools — Alabama and LSU — was a chief motivation for the other leagues to ditch the BCS and create the four-team playoff.
Well, if you think eight is great, if you want to increase not only the number of thrilling playoff games, but also turn these snoozy November Saturdays into a free for all where all the major conference championship races matter, then the tipping point is laying right there to be had.
All it requires is seven results, all but one of which is the predicted outcome.
Notre Dame wins out, defeating Syracuse and USC.
Alabama defeats the Citadel and Auburn.
Georgia defeats Massachusetts and Georgia Tech.
And then … Georgia upsets Alabama in the SEC title game.
That’s it. If those seven games go like that, then the College Football Playoff will feature two SEC teams (Georgia and Alabama, which isn’t dropping past four due to one loss) and an independent (Notre Dame).
One other conference will claim the other spot. It’s most likely the ACC, since Clemson is heavily favored to win out.
It could be any league though. It doesn’t matter because you’d have just two conferences represented in the playoff field … and three major conferences wondering how in the world they ever agreed to a playoff of just four squads?
Oh, my stars! It’s the end of the world as we know it.
Dan’s world has a place in it for Central Florida, not because the Knights are one of the very best teams in college football, but because they’re not.
Much of the debate this fall about the playoff has centered on whether it is inherently unfair to programs outside the Power Five — most notably Central Florida, which is on 22-game win streak but stands virtually no chance of making the playoff.
UCF, due to its schedule, isn’t being mistreated by the committee, though. That said, an eight-team playoff would allow room for it to come in as a No. 8 seed and take an underdog swing at whoever earned the right to be No. 1.
I know my snark isn’t going to sway any of you committed eight-team advocates, but I’ll leave you with a question just the same. How does any of Wetzel’s argument for an eight-team field not apply equally to a sixteen-team field?
Filed under BCS/Playoffs, Media Punditry/Foibles
72 responses to ““It would be a fun embrace of Cinderella for a sport that hates Cinderella.””
Well, you’ve heard this before, Senator, but it at least allows for each undefeated or 1-loss champion of a power 5 conference and any undefeated/1-loss independent, but not likely any 2-loss teams.
A 16-team playoff would almost certainly get down to multiple two-loss teams.
Guys like Wetzel see that as a feature, not a bug.
A 16-team playoff will never work. You would have to cut out the conference championship games (and possibly a regular season game) for a 1st round (the leagues especially the SEC isn’t going to let that happen). The quarterfinals would have to be during or right before fall semester finals (bowl assignments couldn’t be made until this happens). The semifinals and championship game are left alone.
It would be a mess that would show the hypocrisy of big-time college athletics compared to S-A welfare and education.
cpadawg
but not likely any 2-loss teams
In 2014, there were two 2-loss teams in the final CFP top 8.
In 2015, there were two 2-loss teams.
In 2016, there were three 2-loss teams and one 3-loss team.
In 2017, there were two 2-loss team and one 3-loss team.
It may allow for better conference representation, but going to 8 practically guarantees 2-loss teams getting into the playoff. If you go to 16, you’ll have multiple 3-loss teams (half the field in some years), and maybe a four loss team in there somewhere.
Ok, I stand corrected– I was guessing, entirely. Thanks for the numbers!
Put me on the list of people who never want further expansion. I want the Alabama/Auburn game to matter, not be one Bama could afford to rest Tua for example and then play UGA for the marbles. Same with UGA/Tech. If you are not clearly in the top four, you have no argument. The idea isn’t to “give everyone a shot”. In my mind it is the four best teams who get to play the games. NOT some Cinderella. The national champ should be decided by playing three games involving the four best teams, no matter what conference and no matter what title they do or don’t have. UCF would get embarrased by any of the top six or seven teams in the rankings, and could only make for poor football on the field. I feel I am in the minority on this.
Nope, I agree with every word. I like 4 teams but absolutely detest the committee and its weekly shenanigans. If there’s going to be a committee, let them go to Dallas on championship weekend because that’s the only time what they say matters.
Well what does it matter if they meet beforehand? Not sure that would change anything if they met just once after conference championships.
My point exactly … it’s a waste of time on the committee’s part if they are truly starting with a blank sheet of paper every week. They meet to provide ESPN with broadcasting material and to suck more oxygen out of the room that is the college football regular season. If you aren’t in the CFP picture, you don’t matter. You could make the case that the rest of the regular season only matters for about 7 teams because of the release of the weekly rankings by the committee.
The basketball selection committee doesn’t meet every week from January 15 to Selection Sunday and release a current version of the 64 teams in, those on bubble watch and the seeding of the top 25.
Why does the CFP committee need to meet in October or this time of November?
smgattorney
Why does the committee meet in October and November? Programming for ESPN.
ESPN could still have their talking head shows about who’s in and out. They have exactly that in CFB now with Joe Lunardi and all of his Bracketology.
ESPN talking heads release their top 4 the first week of the season.
Got it. I haven’t thought that through as much probably because the Dawgs have been in the conversation the past 2 years and not really worried about anyone else .
Erk's Forehead
Agree. There’ll never be a perfect system. The pursuit of more $$ will ruin a good product on the field. I despise the NFL system. Of course, I also can’t stand the MLB divisional playoffs.
I think the Auburn-Alabama game will always matter, whether the two teams are in playoff contention or not.
Probably said that too when Tech exited the SEC. Not saying it doesn’t matter, but it would look a lot like the one to our west had they never left.
Down island way
Tiiieiiieeeiim is on my side, yes it is……
Morris Day
UCF isn’t even in ESPN’s top 25 FPI (power index) or whatever it’s called.
David K
I think the fact that Georgia hadn’t played Bama last year helped their chances to get in. If we beat them in the SEC Championship game, I think their chances of getting in are slim. They don’t want to set up another rematch if we had just beat them.
This. The Gumps ain’t getting in with a loss to us the day before the selection. Not without something totally crazy.
I guarantee we’ll go to 8 soon. They’ll make it the 5 champions and 3 at large. Then they’ll swear that’s the end of it and that they’ll never expand beyond that.
8 seems reasonable – 5 champs. 1 GO5, 2 at large.
Also, I heard someone propose a Group of 5 playoff. That would be interesting (moreso than those early bowls).
Group of 5 is crazy to not have already gone in this direction. Much more likely to happen, and more profitable to have a series of games with little competition for viewers than have one team in a NYD Bowl.
If Clemson, Michigan and ND win out, I think they are in. Bama got in last year because Big Ten and PAC 12 Champs had 2 losses. But Senator, as you know and I have preached all along, we are on that slippery slope and it is eventually coming to 8 and more. We will render that regular season less and less meaningless. Look at the ratings for regular season College Basketball…the games mean zilch. And there are some who actually want to let everyone in to March Madness. Playoff addicts are playoff addicts.
NCDawg
I just want Cincy to beat UCF this weekend and stop the UCF madness.
thebluestepside
I would ideally like 8 also, for the same reasons others have mentioned- 5 conference champs, 3 at large (or 1 P5 and 2 at large). That just seems logical to me, and would still not diminish the importance of the regular season. I do understand that it would almost certainly expand to 16 teams a few more years down the road, and that’s where the quality of the playoff would really be diminished.
Same old beyond ridiculous scare tactic about 16. Ain’t happening. Anything that gets us to eight is wonderful, but I disagree with Wetzel’s thought about 2 SEC teams getting in under that scenario. The SECCG is a play in game with the loser going elsewhere for a bowl game…and that is fair. But man, the discussion is going to be wild as everyone digs in for their team getting the spot. Under that proposal Clemson and ND will not even be a serious argument. Michigan will stay if they win out. I would love for the Committee to have the gonads to leave Michigan out, but that would leave the sudden death of Delany on their conscience.
They have thus far always had the 4 best teams which is how it is designed. Why mess with success? They should leave it alone.
I agree, but there’s a lot of financial pressure to expand coming from several quarters.
That won’t stop at eight, either. In fact, I’d expect it to intensify.
Playoffs, first and foremost, are about money.
College football, anymore, is first and foremost about money.
The ESPN Invitational is an ESPN property. It wishes to give out invitations in the manner which best serves ESPN.
A lot of people think it is some benevolent act by ESPN to give fans a”true champion.” More viewers will watch, and advertisers will pay more for, 2 big name teams play than Washington State against Iowa State even if Washington State and Iowa State were undefeated conference champions.
What it means for us is to be a team that will attract a lot of viewers nationally as well as a top caliber team. Fortunately we have inherent advantages that make that also automatic.
The point of a playoff should be to include every team that has a viable claim to being the best in the country. In Wetzel’s scenario, both Michigan and Oklahoma would have that claim, as they are right next to UGA right now in the advanced metrics, so if UGA could beat Bama, then those two could as well. A four-team playoff omits them. An eight-team playoff does not. There’s no team lurking at #9 with a reasonable claim to being the best. That’s why eight is a defensible number in a way that 16 is not.
Wetzel gives the game away when he brings up the “C” word.
My problem with your defense of an eight-team field is that, 2007 excepted, we’ve never experienced a season when there were 8 teams with a legitimate argument that they deserved to be in consideration for the national title.
Once you head down the road where non-contenders are included, it hardly matters whether the field is 8, 12 or 16.
This year.
Dawgoholic
So because the #1 team could possibly be beaten by another team, teams equal to that team should get in. So if Auburn beats Bama does that mean we need a 32 team playoff???
Btw, Clemson, Bama, and ND DESERVE a chance this year because they have gone undefeated against at least halfway decent schedules. Everyone else is hoping to get lucky and lost control of their destiny when they lost – some are fortunate enough due to their scheduling and/or conference difficulty to now control their destiny again.
Codie Alan
6 is all you need, that way all the Power 5 conference champions get in (brings value to winning your conference) and there is one at-large spot for the highest ranked group of 5 team and it forces ND to join the ACC). Seeds 1 & 2 get a bye the first round while 3-6 battle it out. 8 is too many and shouldn’t even be in consideration IMO.
ND isn’t going to be forced to do anything. They’ll sue ESPN and the Power 5 before they give up their NBC contract to be one of 15 in the ACC. ESPN isn’t going to pony up for anything that keeps ND out.
Texas has a tv deal that they don’t share. ND could negotiate a similar deal. The great part about the insurance of joining a P5 conference is that if you like your tv plan you get to keep it.
That’s because the Big XII agreement allowed Texas to do it. I would suggest the Longhorn Network did more damage to the Big XII with the loss of A&M and Missouri. I bet the ACC agreement doesn’t have similar contractual terms.
It would have to be negotiated.
Agree but ND holds all the leverage in this case
That’s true, you’d have to find a conference willing to bend over backwards for ND, like the Big XII did for Texas.
Why not just go back to BCS rankings? Top 6 get in. 9 times out of 10 if you win a P5 you’ll be in the top 6, but automatic berths leaves the door open for a 4 loss division champ (Northwestern) to pull off an upset and make it into the field.
The simple answer to you question is that he’s talking about 8 teams and 5 conferences being included. That argument wouldn’t carry over to a 16 team playoff.
That said, I don’t see Bama getting in on you have 2-3 other one loss P5 champions in Oklahoma, Michigan, Wazzou.
Your*
There is only one “snoozy November Saturday”. Every other one is pretty damn good.
If UCF wants to hang with the big boys than quit playing a wuss schedule. It’s a joke.
If you go to 8 or 16, there will be numerous unintended consequences lazy pundits let haven’t even thought of yet.
Let’s say it goes to 8, the 9th team and the Dan Wetzels will be crying about someone getting left out.
Let’s say the do expand and UCF type team is in – there is no possible way that a team like that is going to beat PROGRAMS like Georgia, Clemson, and Alabama three weeks in a row. It’s impossible .
UCF (in a recent article) claims they can’t get the games because big time teams won’t do home-and-homes with them and they believe they are above the Buy-game…….to be fair, they say it’s bad for growing a fan base (not having good opponents in your stadium) which is a position that is not without merit.
They think wrong. FSU had the blueprint for rising to the top, let them play road games and earn their respect. The buy-in will be more expensive to land them but there is a path, they just want the easy path…doesn’t most everyone. Screw ’em. Teams that award themselves titles deserve nothing close to respect.
Good point. And FSU did that BEFORE the massive amount of TV content, in a time where if they weren’t in Tallahassee it was likely their fans wouldn’t get to see them play. Now, that out-of-sight / mind principle is much less problematic.
I think that a Big 10 champion Michigan gets in over a 1 loss Bama for all these reason.
Throw the Big 10 a bone after getting shutout last season and probably push back on some of the expansion talk.
An 8 team playoff would help. But to really settle it, we need a 130 team playoff. Of course, at the very least, the FCS champion should get a shot as well. We all know any one of them can compete on any given Saturday. So really then, a 130+1 team playoff would settle things..But that would still leave out the true Cinderellas of Div III. So maybe we should seriously look at an infinity team playoff? You know…to make it exciting.
SouthernYank
I enjoy and encourage your snark.
“How does any of Wetzel’s argument for an eight-team field not apply equally to a sixteen-team field?”
Seems to me that Wetzel’s arguing for all P5 conference champs to be included in the playoffs. That doesn’t require 16 slots.
But how do you determine which is the best Group of 5 team to include in an 8 team playoff? We need to add them all!
I’ll say it again. The best option is to go to 8 12 team conferences, let the 35 or so that are left out go to FCS and ND has to get over itself and get in a conference. Let each conference determine it’s champion however it wants to and have a three round, 8 team playoff of conference champions to decide the national championship. If a conference has three great teams ranked in the top 5 to end the regular season, two of them are going to be disappointed and can talk forever about how they really should have gone to the playoff instead of some weaker team from another conference, that is one of the great things about sports, the “what ifs”.
Until the highest level of college football’s national championship is decided on the field in an objective playoff format any claimed “championship” will be a sham.
Have no issue with 8 conference winners, or a four 16 team conferences with four winners from their championship game, but that is so much harder than expanding to eight immediately. Unraveling the contracts and lawsuits would take decades, imo.
To settle this AND keep the 4 team playoff, you could institute TBD blocked in seeded non-conference scheduling during the last few weeks of November. Think SEC-Big 12 challenge in basketball.
Play 8 straight SEC games to start the season, with the SEC title game in late October, with the non-participants playing a 9th mandatory inter-divisional game that is set on which division is home/away for at least a modicum of planning.
Every P5 then plays 4 straight non-conference games in November. Home or Away and Conf vs. Conf has a specific rotation. All seeded according to their finish within the conference. Of course, this would require the Pac12 and Big 12 to expand to 14—maybe Notre Dame could rotate between those two for who they “caucus” with. This at least sorts out some of it, keeps the regular season in tact with a compelling November “mystery” opponent(s).
/Not sure what happens to Tech.
Junkyardawg41
For those of you who think an 8 team playoff would include the P5 Conference champs plus some at large teams, you are sadly mistaken. If conference championships don’t matter now, it won’t matter with 8 teams. The mandate for the “best” teams” may end up having 3 teams from one conference. To the Senator’s point, what changes from 4,8,12,16 + from a best team approach? I can’t see it.
Also, there’s no reason it couldn’t be six teams instead of eight.
Only way 2 sec teams get in is if these teams lose a game: ND, Mich, tOSU, WVA, Ok, clemmons and WSU. Two of those 7 teams will definitely loose in head-to-head games. So that will leave at most 5 teams vying for 3 spots. Oh, and bama must lose to us also. Not very good odds for the sec, but it’s happened before…
whb209
Leave it just the way it is…
When you have 5 or 6 teams bitching that they should have been in the play-off, it only helps college football. Bitch all year and everyone will be pumped for the next year to start.
UGA '97
MO playoff games = mo football = good, luv it
Larry R Butler
Auburn..you had one job
beat UCF.
A lot of this is your fault.
I’m not sure why this is a question because the answer is simple:
The 8 team playoff includes all 5 Power5 champions.
That is its primary feature and it is 100% accomplished by 8 teams and is not an argument in any way, shape, or fashion for a 16 team playoff.
Right… until one of the five gets in with a four-loss record.
Or until the SEC takes every at-large spot.
Texas Dawg
No matter how may teams get in, there will always be complaining. How many teams get and invite to March Madness now? 64, 65? Even with that number 66, 67,68… is jumping up and down swearing they got the shaft and the system is stacked against them.
I think that a 6 team playoff would be best. You could take all power 5 champions plus 1 at large. That at large would be an undefeated group of 5 team or if there isn’t one of those then a power 5 conference runner up. If the big boys win their conference championship then they’re in no matter if they have 1 or 2 losses. The group of 5 would obviously need to win their conference championship but also sport an undefeated record. The automatic bid for the power 5 might also push us to at least a 9 game conference schedule since it wouldn’t kill a teams chance if they have 1 or even 2 losses. There will be issues with any format but I think this is the one that at least gives every team a legitimate shot at a NC on any given year.
PBR1975
I didn’t see this before I posted, I agree!!
The problem that I see, and the scenario that I could actually see playing out is a one loss team winning a conference title over a #1 undefeated (regular season) team getting left out. Some say that WHEN the Dawgs beat Bama that Bama will stay in the top 4 even with Clemson and the Domers staying undefeated and Michigan winning their conference. Can anyone say that Mich. isn’t playing like one of the top 4 teams? No. So, what does that do for the Dawgs if you leave Bama in as a conference loser? #5!! Do you kick out a one loss Michigan Conference Winner? If so, how? Why play the Conference Championship game? Worked for Bama last year (Not even a Division Winner).
-Expand to 6 teams
-The 5 conference winners and one at-large.
-Reseed
-1 & 2 get a first round by
-Have a play in game the week after conference title game for 3 – 6
-Proceed as usual for the Semi and Final
Oh and this still leaves Bama or Notre Dame out in this (Let the arguments start for the At-Large or Notre Dame can get into a conference).
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BMC Cardiovascular Disorders
Measurement of blood pressure for the diagnosis and management of hypertension in different ethnic groups: one size fits all
Paramjit Gill1,
M. Sayeed Haque1,
Una Martin2,
Jonathan Mant3,
Mohammed A. Mohammed4,
Gurdip Heer1,
Amanpreet Johal1,
Ramandeep Kaur1,
Claire Schwartz5,
Sally Wood5,
Sheila M. Greenfield1 &
Richard J. McManus5
BMC Cardiovascular Disorders volume 17, Article number: 55 (2017) Cite this article
Hypertension is a major risk factor for cardiovascular disease and prevalence varies by ethnic group. The diagnosis and management of blood pressure are informed by guidelines largely based on data from white populations. This study addressed whether accuracy of blood pressure measurement in terms of diagnosis of hypertension varies by ethnicity by comparing two measurement modalities (clinic blood pressure and home monitoring) with a reference standard of ambulatory BP monitoring in three ethnic groups.
Cross-sectional population study (June 2010 - December 2012) with patients (40–75 years) of white British, South Asian and African Caribbean background with and without a previous diagnosis of hypertension recruited from 28 primary care practices. The study compared the test performance of clinic BP (using various protocols) and home-monitoring (1 week) with a reference standard of mean daytime ambulatory measurements using a threshold of 140/90 mmHg for clinic and 135/85 mmHg for out of office measurement.
A total of 551 participants had complete data of whom 246 were white British, 147 South Asian and 158 African Caribbean. No consistent difference in accuracy of methods of blood pressure measurement was observed between ethnic groups with or without a prior diagnosis of hypertension: for people without hypertension, clinic measurement using three different methodologies had high specificity (75–97%) but variable sensitivity (33–65%) whereas home monitoring had sensitivity of 68–88% and specificity of 64–80%. For people with hypertension, detection of a raised blood pressure using clinic measurements had sensitivities of 34–69% with specificity of 73–92% and home monitoring had sensitivity (81–88%) and specificity (55–65%).
For people without hypertension, ABPM remains the choice for diagnosing hypertension compared to the other modes of BP measurement regardless of ethnicity. Differences in accuracy of home monitoring and clinic monitoring (higher sensitivity of the former; higher specificity of the latter) were also not affected by ethnicity.
Hypertension is the leading risk factor for cardiovascular disease (CVD), accounting for approximately 45% of global CVD morbidity and mortality [1]. The prevalence of hypertension in various regions of the world has been reported [2, 3] and there are striking differences in both blood pressure (BP) level and hypertension prevalence between ethnic groups. For example, adults of West African descent in Europe and North America, whether they come directly from Africa or indirectly from the Caribbean, generally have higher BP and a higher prevalence of hypertension than those of European descent, with this being seen at all ages in North America and only from adulthood in the UK [4, 5].
The diagnosis and management of BP in the UK are informed by guidelines largely based on research from white populations [6]. These guidelines recommend diagnostic and treatment thresholds for hypertension on the basis of office BP and 24 h Ambulatory blood pressure monitoring (ABPM) or home BP monitoring. The need to adjust between clinic and “out-of-office” thresholds for diagnosis makes this particularly important and current recommendations were derived from Australian data gathered in a population that was 82% white and 15% Asian [7]. They suggest a decrease of 5/5 mmHg when converting from clinic to –out-of-office measured BP at lower levels (stage 1 threshold) and a corresponding decrease of 10/5 mmHg at higher levels (stage 2 threshold). We have shown that BP differences between ethnic groups are small [8] and currently ethnicity is not considered in the specification of these UK thresholds, treatment targets or adjustment factors. Hence this study addressed whether accuracy of diagnosis of hypertension using home monitoring and clinic BP are comparable for White British (WB), South Asians (SA) and Black African Caribbean (AC) UK ethnic groups using ABPM as a reference standard.
The design and results of the BP in different ethnic groups (BP-Eth) study has previously been published [8, 9]. This was a cross-sectional population study which took place between June 2010 - December 2012 involving people recruited from 28 general practices in Central England.
The study population comprised two groups aged between 40 and 75 years: The first group were not known to be hypertensive (NHT) and the second had been previously labelled as hypertensive via a clinical code (HT). Participants were drawn from one of four ethnic groups namely WB, SA, AC and White Irish (WI). WI participants were excluded from this analysis due to insufficient numbers recruited (51). Patients that were unable to give consent to the study, belonged to a different ethnic group or whose general practitioner (GP) felt they were unable to take part were excluded.
The study compared BP monitored in a clinic setting and from home-monitoring with ambulatory measurements. Recruitment was from those responding to a postal survey who indicated a willingness to participate in a validation study [8, 9]. Respondents were purposefully sampled from those willing to take part on the basis of ethnicity and hypertension status and invited to attend clinics run at their own practices by research nurses using standardised protocols.
Following informed consent and a five minute rest, six sets of BP measurements were taken by the research nurse at each of three clinic visits (BpTru Medical Devices BPM-100) [10]. On the first occasion BP was measured simultaneously on both arms and thereafter it was measured on the non dominant arm unless the difference in systolic pressure was >20 mmHg between both arms in which case it was measured in the arm with the higher reading [6].
Participants were fitted with an ambulatory monitor (Spacelabs 90217-1Q) [11] (or given a home monitor (Microlife watch BP home)) [12] on either the first or second visit. The third and final visit took place 10 days after the first to allow adequate time for both ambulatory and home BP measurements to be undertaken. The order of ambulatory and home monitoring was varied so that approximately half of the participants had each method first. All staff involved in the study underwent training by the lead research nurse in order to ensure a consistent approach.
Ambulatory readings were recorded at half hourly intervals during the day (7 am to 11 pm) and hourly overnight and the mean daytime BP calculated. Home measurements were taken twice each morning and evening for 1 week, the first days readings discarded and the mean of the remaining readings calculated. For both home-monitored and day time mean ambulatory blood pressure, standard editing criteria were applied: ABPM readings were considered to be valid if there were 14 or more day-time (7 am to 11 pm) readings for a patient (threshold 135/85 mmHg) [13]. Home-monitored readings, minimum of 12 readings, were considered valid if there were 4 or more days readings using the average excepting the first day’s readings (threshold 135/85 mmHg) [14].
Clinic measurement was defined in three ways: the mean of the 2nd and 3rd reading averaged over the 3 days (Clinic23: standardised clinic, threshold 140/90 mmHg) representing recommended clinic BP measurement for diagnosis; the mean of the 2nd to 6th reading averaged over three occasions (Clinic26: research clinic, threshold 135/85 mmHg) and the first reading taken on the first day (ClinicD1R1: casual clinic, threshold 140/90 mmHg), which was expected to accentuate any white coat effect.
The primary outcome was the diagnostic test performance of various measures of clinic and home-monitored BP compared to the reference standard (mean daytime ambulatory BP) considering both diagnosis of hypertension in those not previously diagnosed and identification of poor control in those known to be hypertensive, using a threshold of 140/90 mmHg for clinic readings and 135/85 mmHg for out-of-office measurement [6]. The same measurement methodology and thresholds were used for hypertensive and non-hypertensive individuals.
People with and without a previous diagnosis of hypertension were analysed separately and the impact of ethnicity was assessed.
The continuous response variable was systolic or diastolic BP. The study design involved clustering effects (BP readings nested within days and patients), so we used a hierarchical linear statistical model to reflect the design. A 3-level hierarchical model was developed, with level 1 as the BP readings, level 2 as the day (the readings were taken) and level 3 as the patient. All models had a pre-specified set of covariates: ethnicity, age, sex, marital status, deprivation (IMD 2007), body mass index, smoking status, alcohol consumption, cholesterol, cardiovascular disease, chronic kidney disease, diabetic status, and hypertension status. Five separate models were constructed, one for each method—ABPM, clinic23, clinic26, clinic D1R1 and home monitoring. For clinic D1R1 there was no hierarchical structure as there was a single observation per participant (a simple linear regression model was used). Participants with complete data were included in the analyses. All analyses were undertaken in Stata (release 12) [15, 16].
Sensitivity, specificity, likelihood ratio of a positive test (LR + ve) and likelihood ratio of a negative test (LR –ve) for either a diagnosis of hypertension or confirmation of raised BP in those known to be hypertensive, were calculated for each ethnic group and also for all samples for Clinic23, Clinic26, ClinicD1R1 and home monitoring using mean day-time ABPM as a reference standard.
Baseline data: demographics and past medical history
A total of 551 patients had complete records in the study (246 WB, 158 AC, and 147 SA) (Table 1). More hypertensives than non-hypertensives had complete data in each group. The WB group were older than the other two and more likely to drink alcohol. The SA group had a lower prevalence of smoking but were more likely to be diabetic.
Table 1 Characteristics of study population
The differences seen between ethnic groups overall were largely mirrored within those with and without hypertension, although hypertensives were older, had more co-morbidities and were less likely to be working (Table 1).
As there was no difference between raw and modelled data, modelled data are provided (see Additional file 1 of diagnostic output of raw data at different BP thresholds).
Diagnostic test performance for raised BP without a diagnosis of hypertension
The results for diagnostic test performance compared to an ambulatory BP above 135/85 mmHg in people not known to be hypertensive – i.e. for a diagnosis of hypertension - were similar for each ethnic group within each alternative method of measurement evaluated. Considering the individual measurement methods for all patients combined, there was low sensitivity for clinic23 with high specificity (Fig. 1; Table 2). For clinic26 measurement, the sensitivities were better than those of Clinic23 with relatively lower specificity. For ClinicD1R1 sensitivity was much lower particularly amongst SAs but there were high specificities. For home-monitoring, sensitivity was higher and specificity was lower than clinic measurements.
Sensitivity and specificity non-hypertensive
Table 2 Non-Hypertensive: diagnostic performance for hypertension defined by mean daytime ABPM
Diagnostic test performance for controlled BP in people with a diagnosis of hypertension
The results for diagnostic test performance compared to an ambulatory BP above 135/85 mmHg in people known to be hypertensive –i.e. for a confirmation of poor control - were also similar for each ethnic group within each alternative method of measurement evaluated. As with those not known to be hypertensive, overall clinic23 measurement had low sensitivity with high specificity. Clinic26 measurement had moderate sensitivity and lower specificities whereas ClinicD1R1 measurement had similarly low sensitivities and specificities. Home-monitoring had high sensitivities but lower specificities (Fig. 2; Table 3).
Sensitivity and specificity hypertensive
Table 3 Hypertensive
The key finding from this work is that using ABPM as a reference standard, the accuracy of clinic and home measured BP in terms of both diagnostic test performance or ability to confirm controlled BP, does not vary by ethnic group. Standard clinic measurement on three occasions was specific but not sensitive and this did not change materially with different combinations of clinic measurement. Home readings were more sensitive with a modest reduction in specificity but were not good enough for a life-long diagnosis. For people with established hypertension, only home monitoring had reasonable sensitivity with standard (mean clinic23) specific enough – just short of 90% - for daily practice.
This leads us to conclude that for people without hypertension, ABPM remains the choice for diagnosing hypertension compared to the other modes of BP measurement because no other method has sufficient combined sensitivity and specificity on which to base lifelong treatment. Given that systematically measured repeated clinic BP had high specificity, it may be reasonable to treat people with raised mean clinic BP on multiple occasions, but clinic BP could not adequately rule out hypertension and casually measured BP performed poorly. Home-monitored BP was reasonably sensitive and specific but probably not enough so to provide an adequate replacement for ABPM. Sensitivity analyses using BP thresholds of 135/85 mmHg and 140/90 mmHg were undertaken and showed no difference between the ethnic groups.
For people with established hypertension, a sensitivity of 84% from home monitoring is high enough to accept evidence of good control but specificity was low enough to reduce confidence about reacting to high readings.
This is the first and largest study reporting four modes of BP measurement compared to ambulatory BP monitoring in three different ethnic groups. Participants were both hypertensive and not known to be hypertensive and importantly were not recruited on the basis of previously raised BP which has confounded much of the work on out of office measurement in the past. The attempt to recruit a White Irish group – known to have increased cardiovascular risk – failed due to a lack of numbers of people self-defining as White Irish, despite choosing areas previously identified by census ethnicity responses. This may reflect changes in population since 2001 (the study recruited before 2011 data were available). In light of the results in the groups considered, it seems unlikely that WI would be markedly different. Similarly, people with hypertension responded in greater numbers to our invitations to take part resulting in fewer without a previous diagnosis participating. The key results presented – namely a lack of difference between ethnic groups - were low in heterogeneity between the groups and largely consistent across methods and with or without a diagnosis so appear robust.
The measurement of BP in this study was undertaken in a consistent manner by trained research nurses and facilitators and probably reflects better practice than common outside of specialist centres. Whilst this was a prerequisite for the study, it arguably did not represent usual practice and hence the results might not be generalizable to daily practice. The use of a single reading taken at the first research clinic was designed to both accentuate any white coat effects and also to represent the potential practice of BP measurement in busy clinical settings and proved suboptimal for both diagnosis and ongoing management.
Patients included were chosen to be aged within the range used in NHS Health Checks (40–74) as this is the key age group for whom primary prevention is particularly relevant and for which decisions are commonly made in terms of diagnosis and treatment [17]. Inclusion of older people might have provided information on the diagnosis of hypertension in a group for which evidence for the benefit of treatment is accumulating but would have required different diagnostic thresholds to be applied [18].
The overall performance of clinic (sensitivity 41%/specificity 90%) and home monitoring (73%/76%) for the diagnosis of hypertension are consistent with the receiver operating curves in our previous systematic review which found respectively sensitivities and specificities of clinic (75%/75% (86%/46% for patients around the threshold for diagnosis)) and home (86%/66%) [19].
Since that review, Nasothimiou [20] has found sensitivity and specificity of around 90% for home monitoring in over 600 Greek people referred to a hypertension clinic in comparison to our findings. This may reflect differences in inclusion criteria of that study compared to the community based, diverse population group in the current sample which was not recruited due to their initial BP being raised.
No comparative studies amongst different ethnic groups for the diagnosis of hypertension were apparent from a review of the literature although some studies have grouped together whites with people of Hispanic and/or African origin [21, 22]. The current study therefore represents novel data on which diagnostic decisions taken in a multicultural setting can be based. Given the similarities between the results for those of African Caribbean and South Asian ethnicity with White British it seems unlikely that other ethnicities will have significant differences either, although this would need to be tested.
With greater numbers of individuals in primary care now undergoing out of office BP measurement prior to a diagnosis of hypertension, then this work is reassuring in that it appears appropriate to extend thresholds developed in white populations to South Asian and African Caribbean populations at least.
When making a diagnosis of hypertension in an unselected primary care population, the low sensitivity of clinic measurement means that it cannot reliably be used to rule out hypertension but with high specificity, those found to have high BP on multiple occasions in clinic can be reliably identified and treatment commenced.
In terms of ongoing management of hypertension, the mode of measurement appears more important than the population being measured in terms of variation. In any case, home monitoring would appear to be a reasonable method of ruling out raised BP and in combination with careful clinic measurement provides high specificity in addition. Such a result resonates with the ever growing evidence of improved BP control with the use of home-monitoring, with or without other interventions [23].
In the future, alternative methods of measurement of BP such as central arterial pressure may have increased clinical utility as data accumulate [24]. The feasibility of central pressure measurement in routine clinical practice and its evidence base is increasing.
Overall the findings confirm those of our previous review [19] that in comparison to ABPM, neither clinic nor home measurement of BP has sufficient clinical value for the diagnosis of hypertension and adds that this is unchanged in South Asian and African Caribbean populations. For ongoing management, combining home and careful clinic measurement appears optimal. Overall, this large study in three different UK ethnic groups has shown that in both the diagnosis and management of hypertension, the method chosen need not be influenced, in terms of test performance at least, in terms of the ethnicity of the individual being tested.
ABPM:
Black African Caribbean
Clinic23:
Standardised clinic, threshold 140/90 mmHg
Research clinic, threshold 135/85 mmHg
ClinicD1R1:
Casual clinic, threshold 140/90 mmHg
CVD:
GP:
General practitioner/family medicine
HT:
Hypertensive via a clinical code
IMD:
Index of multiple deprivation
LR –ve:
Negative likelihood ratio
LR + ve:
Positive likelihood ratio
NHT:
Not known to be hypertensive
South Asians and UK
WB:
White British S
WI:
White Irish
A global brief on Hypertension: Silent killer, global public health crisis. WHO: Geneva;2013.
Chow CK, Teo KK, Rangarajan S, et al. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013;310(9):959–68.
Danaei G, Finucane MM, Lin JK, et al. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5 · 4 million participants. Lancet. 2011;377:568–77.
Agyemang C, Bhopal R. Is the blood pressure of people from African origin adults in the UK higher or lower than that in European origin white people? A review of cross-sectional data. J Hum Hypertens. 2003;17:523–34.
Agyemang C, Humphry RW, Bhopal R. Divergence with age in blood pressure in African-Caribbean and white populations in England: implications for screening for hypertension. Am J Hypertens. 2012;25:89–96.
Hypertension in Adults: Diagnosis and Management. NICE Clinical Guideline CG127. https://www.nice.org.uk/Guidance/CG127. Accessed 28 Oct 2016
Head GA, Mihailidou AS, Duggan KA, Beilin LJ, Berry N, Brown MA, et al. Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study. BMJ. 2010;340:c1104.
Martin U, Haque MS, Wood S, Greenfield SM, Gill PS, Mant J, Mohammed MA, Heer G, Johal A, Kaur R, Schwartz C, McManus RJ. Ethnicity and differences between clinic and ambulatory blood pressure measurements. Am J Hypertens. 2015;28(6):729–38.
Wood S, Martin U, Gill P, et al. Blood pressure in different ethnic groups (BP-Eth): a mixed methods study. BMJ Open. 2012;2(6). doi: 10.1136/bmjopen-2012-001598.
Mattu GS, Perry Jr TL, Wright JM. Comparison of the oscillometric blood pressure monitor (BPM‐100 Beta) with the auscultatory mercury sphygmomanometer. Blood Press Monit. 2001;6:153–9.
Baumgart P, Kamp J. Accuracy of the SpaceLabs Medical 90217 ambulatory blood pressure monitor. Blood Press Monit. 1998;3:303–7.
Stergiou GS, Giovas PP, Gkinos CP, Patouras JD. Validation of the Microlife WatchBP Home device for home home blood pressure measurement according to the International Protocol. Blood Press Monit. 2007;12:185–8.
Staessen JA, Bieniaszewski L, O’Brien ET, Imai Y, Fagard R. An epidemiological approach to ambulatory blood pressure monitoring: the Belgian Population Study. Blood Press Monit. 1996;1(1):13–26.
Staessen JA, Birkenhäger W, Bulpitt CJ, Fagard R, Fletcher AE, Lijnen P, Lutgarde T, Antoon A. The relationship between blood pressure and sodium and potassium excretion during the day and at night. J Hypertens. 1993;11(4):443–7.
StataCorp. Stata statistical software: release 12. College Station: StataCorp LP; 2011.
R Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2013. http://www.R-project.org/. Accessed 28 Oct 2016.
http://www.healthcheck.nhs.uk. Accessed 28 Oct 2016.
Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887–98.
Hodgkinson J, Mant J, Martin U, Guo B, Hobbs FD, Deeks JJ, Heneghan C, Roberts N, McManus RJ. Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension: systematic review. BMJ. 2011;342:d3621.
Nasothimiou EG, Tzamouranis D, Rarra V, Roussias LG, Stergiou GS. Diagnostic accuracy of home vs. ambulatory blood pressure monitoring in untreated and treated hypertension. Hypertens Res. 2012;35:750–5.
Ogedegbe G, Pickering TG, Clemow L, Chaplin W, Spruill TM, Albanese GM, et al. The misdiagnosis of hypertension. Arch Intern Med. 2008;168:2459–65.
Shimbo D, Kuruvilla S, Haas D, Pickering TG, Schwartz JE, Gerin W. Preventing misdiagnosis of ambulatory hypertension: algorithm using office and home blood pressures. J Hypertens. 2009;27(9):1775–83.
Uhlig K, Patel K, Ip S, Kitsios GD, BalK EA. Self-measured blood pressure monitoring in the management of hypertension: a systematic review and meta-analysis. Ann Intern Med. 2013;159(3):185–94.
McEniery CM, Cockcroft JR, Roman MJ, Franklin SS, Wilkinson IB. Central blood pressure: current evidence and clinical importance. Eur Heart J. 2014;35(26):1719–25.
All the patients and general practices. Mr Roger Holder, previously Head of Statistics at Primary Care Clinical Sciences, University of Birmingham and Jamie Coleman, Consultant Clinical Pharmacologist at University Hospital Birmingham were original co-applicants who assisted in the design of this study before moving on to other projects. Hardeep Sandhar (database developer) and Kirandeep Jheeta (data manager) gave important support and developed the data strategy. Sabina Yasin helped with initial research clinics. Mr David Yeomans served as PPI representative on the steering group and has given helpful advice throughout. The authors would like to acknowledge their contribution to this work.
We would like to acknowledge the input of participating patients, practices, and the Primary Care Research network without whom this research would not be possible. PCRN Research team:
Elaine Butcher, Tracey Adcock, Jenny Stevens, Rebecca Foskett, Shirley Caldwell, Indra Forsyth, Sian Jones, Karen Cooke, Kathryn Dwyer and Karen Townshend. Participating Practices: Ridgacre Medical Centers, Dr Saunders; Bartley Green Medical Centre, Dr M.K. Alam and Partner, Dr Alam; Church Road Surgery, Dr S. Sawar; City Road Medical Centre, Dr Abrol; Cavendish House Medical Practice, Dr Madhaven; Eden Court Medical Practice, Dr Beighton; Five Ways Health Centre, Dr Surdhar; Grange Hill Medical Surgery, Dr Patel; Greenridge Surgery, Dr Lumley; Handsworth Wood Medical Centre, Dr Bramble; Hawkesley Medical Practice, Dr Shipman; Laurie Pike Health Centre; Newtown Health Centre, Dr Mukherjee; The Omnia Practice, Dr Sabir; River Brook Medical Centre, Dr Chauhan; Rotton Park Medical Centre, Dr Marok; Shanklin House Surgery; Soho Road Primary Care Centre, Dr Bathla; The Wand Medical Centre, Dr Goodwin; Alfred Squire Road Health Centre; Lea Road Medical Practice; Tudor Medical Centre; Whitmore Reans Health Centre; Forum Health Centre, Dr Chohan; Edgwick Medical Centre, Dr Mishra; Engleton House Surgery, Prof. Dale.
This article presents independent research funded by the National Institute for Health Research (NIHR) under the Research for Patient Benefit Programme. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
NIHR Research for Patient Benefit (Grant reference PB-PG-1207-15042); Service support costs via Birmingham and the Black Country Comprehensive Local Research Network, recruitment supported by the Central England Primary Care Research Network (PCRN-CE). RJM was supported by an NIHR Career Development Fellowship and is now supported by an NIHR Professorship.
The funders and sponsor of the study had no role in the study design, and were not involved in data collection, data analysis, data interpretation, writing of the report, or in the decision to submit the results for publication. Both Primary Care Clinical Sciences, University of Birmingham and Primary Care Health Sciences, University of Oxford, are members of the NIHR School for Primary Care Research.
The datasets generated and/or analysed during the current study are available, with permission, from Professor Richard McManus (richard.mcmanus@phc.ox.ac.uk).
RJM and UM had the original idea for this work and gained funding in collaboration with PG, JM, SG, JC and MM. GH, AJ, CS and SW collected the data in collaboration with colleagues in the PCRN-CE. SH and MM did the analyses. PG, RJM, UM, SH wrote the first draft of this paper and all authors subsequently assisted in redrafting and have approved the final version. All authors read and approved the final manuscript.
Ethical approval was gained from the Black Country Research Ethics Committee: Ref 09/H1202/114. All participants provided written consent to participate in the study.
Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Paramjit Gill
, M. Sayeed Haque
, Gurdip Heer
, Amanpreet Johal
, Ramandeep Kaur
& Sheila M. Greenfield
Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Una Martin
Primary Care Unit, University of Cambridge, Cambridge, CB2 0SR, UK
Jonathan Mant
School of Health Studies, University of Bradford, Bradford, BD7 1DP, UK
Mohammed A. Mohammed
Primary Care Health Sciences, NIHR School for Primary Care Research, University of Oxford, Radcliffe Observatory Quarter, Woodstock Rd, Oxford, OX1 2GG, UK
, Sally Wood
& Richard J. McManus
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Correspondence to Paramjit Gill.
Diagnostic output of raw data at different BP thresholds. (DOCX 19 kb)
Gill, P., Haque, M.S., Martin, U. et al. Measurement of blood pressure for the diagnosis and management of hypertension in different ethnic groups: one size fits all. BMC Cardiovasc Disord 17, 55 (2017) doi:10.1186/s12872-017-0491-8
Diagnosis of hypertension
Hypertension and Cardiovascular Risk
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The My Lai Massacre
Usa: My Lai Military Court Acquits Sergeant Mitchell (1970)
A military court at Fort Hood in the American state of Texas yesterday (Saturday) acquitted Staff Sergeant david Mitchell, the first man to be charged over the alleged My Lai massacre more than two year ago.
U.S.A.: Army Introduces Psychological Training To Avoid Future My Lai-Type Massacres (1971)
The United States Army is taking action to avoid repetitions of the My Lai massacre in South Vietnam.
U.S.A.: My Lai Defendant Captain Median Flies To Vietnam To Collect Evidence. (1971)
Captain Ernest Medina, who faces charges in connection with the My Lai massacre, left the United States with his attorneys yesterday for Vietnam.
U.S.A.: Lt. Calley Believes He Was Following Orders In My Lai Massacre, Says Defence Lawyer (1971)
Lieutenant William Calley is admitting at his Fort Benning court martial that he killed South Vietnamese civilians at My Lai village in 1968.
South Vietnam: Hundreds Of People Attend Memorial Service For Victims Of My Lai Massacre. (1976)
Hundreds of people attended a memorial service for the victims of the My Lai massacre in Quang Ngai Province of South Vietnam on Tuesday (16 March).
U.S.A.: My Lai Murder Charge Captain Seeks Support In Home Town (1970)
Captain Ernest Medina, one of the United States Army officers charged with murder in the "Pinkville Massacre" at the South Vietnam hamlet of My Lai on March 16, 1968, returned to his home of Montrose, Colorado on Thursday (August 13) in search of character witnesses.
Usa: Lieut. Calley Stays Home While Waiting For Jury To Bring In Verdict On My Lai Massacre Trial. (1971)
The six-man military jury on the My Lai Massacre trial in Fort Benning, Georgia, tonight ended their second day of deliberations by calling for a refresher hearing on part of the evidence - a request that makes an early verdict in the case unlikely.
U.S.A.: Former Private Testifies Against Lieut. Calley In My Lai Court Martial. (1970)
A former member of Lt. Calley's platoon in Vietnam has testified against him in the?
South Vietnam: My Lai Investigation Team Arrives (1969)
Usa: Meadlo On My Lai Court Martial (1970)
Usa: Mitchell Innocent My Lai Killings (1970)
U.S.A.: Former Lieutenant Calley, Involved In The My Lai Massacre, In Now Free. (1974)
Former United States Army Lieutenant William Calley was released on Saturday (9 November). He had?
Usa: Captain Medina Speaks After Acquittal On My Lai Massacre Charges. (1971)
A five-man military jury on Wednesday (22 September) acquitted U. S. Army Captain Ernest Medina?
U.S.A.: Accused Soldier's Attorney Claims Central Intelligence Policy Agency Was Involved In My Lai Killings. (1970)
When Sgt. David Mitchell was due to face a court martial at Fort Hood, Texas,?
South Vietnam: General Peers & My Lai Investigation Team Departs. (1970)
Singapore: Students Protest Against Alleged My Lai Massacre 16mm 38' Lib No Dope (1969)
STUDENTS SINGAPORE DEMONSTRATIONS SINGAPORE
South Vietnam: Gen. Peers At Press Conference After My Lai Investigation, Then Departs (1970)
S.Vietnam: Lt. Calley Freed. (1974)
LIEUTENANT WILLIAM CALLEY, THE ONLY MAN CONVICTED IN THE MASSACRE OF 22 SOUTH VIETNAMESE CIVILIANS AT MY LAI, WAS SET FREE IN ONE THOUSAND DOLLARS BAIL WEDNESDAY.
United States: Sen. Kennedy Comments On The Calley Trial And The Immorality Of The Vietnam Conflict/vice President Agnew Opposes Anti-War Factions. (1971)
Despite President Richard Nixon's decision to free Lieutenant William Calley, pending appeals in the My Lai massacre case the furore over the sentencing of Calley to life imprisonment continues.
Usa: Court Martial Of Lieutenant Calley Adjourns For Three Weeks (1970)
The court martial of Lieutenant William Calley, accused of being implicated in the massacre of civilians in the South Vietnamese village of My Lai in 1968, was adjourned yesterday (Thursday, 17 December) for three weeks.
U.S.: Calley Returns To His Own Quarters As Senior Officer Faces Trial. (1971)
Lieutenant William Calley, who last week was convicted of the My Lai "massacre" three years ago in South Vietnam and sentenced to life imprisonment with hard labour, has been allowed to live meantime in his own quarters.
Usa: As Lieut. Calley Is Sentenced To Life Imprisonment Thousands Of Telegrams & Calls Pour In His Defence. (1971)
Lieutenant William Calley heard the sentence of "life imprisonment" passed yesterday (Wednesday) in the Fort Benning Courtroom, where he has been on trial for the past four months for the killing of 23 people in the South Vietnam village of My Lai.
U.S.A.: Army Drops Charges Against Captain Thomas Willingham In South Vietnam Alleged Massacre. (1970)
The Army dismissed "for lack of evidence" all charges against Captain thomas K. Willingham, an?
Usa: President Nixon Forecasts End To Vietnam War. (1969)
IN A TELEVISED PRESS CONFERENCE IN WASHINGTON ON MONDAY (DECEMBER 8), PRESIDENT NIXON SAID THAT THE VIETNAM WAR WOULD END REGARDLESS OF WHAT HAPPENED AT THE CONFERENCE TABLE.
United States: Gen. Westmoreland, Former Vietnam Commander, Comments On The Calley Trial. (1971)
United States' Army Chief of Staff, General William Westmoreland left Washington to give a speech to the Texas National Guard Association Yesterday (3 April) in Houston.
South Vietnam And U.S.A.: Calley Verdict Reaction. (1971)
THE TRIAL IN FORT BENNING, GEORGIA, OF 27-YEAR-OLD U.S. ARMY OFFICER LIEUTENANT WILLIAM L. CALLEY?
Usa: Title Missing (1969)
Colonel Oren K. Henderson, former commander of the U.S. Army's 11th Brigade of the Americal?
Usa: After Lieut: Calley Found Guilty Defence Lawyer Says System & Society Should Share The Blame. (1971)
LIEUTENANT WILLIAM L. CALLEY WAS YESTERDAY (MONDAY) FOUND GUILTY OF THE PREMEDITATED MURDER OF 23?
Usa: Viet Veteran Testifies At Atrocity (1971)
....HE DESCRIBES EYEWITNESS ACCOUNT OF MASSACRE OF 30 VIETNAMESE WOMEN AND CHILDREN YEAR AFTER MY?
Usa: Maddox And Wallace Speak At Pro-Calley Ralley (1971)
THEN GEORGE WALLACE SPEAKING, SAYING IN OTHER WORDS, THAT FINAL REVIEW AND DECISION IN CALLEY CASE SHOULD BE MADE QUICKLY, NOT GO ON AND ON LIKE THE MANSON TRIAL (HE REFERS TO IT AS THE CASE IN CALIFORNIA) WITH INDEFINITE TIME FOR APPEALS, AND THAT POLITICIANS HAD BETTER NOT PROLONG THIS THING PAST THE NEXT ELECTIONS, CHEERS AND APPLAUSE.
Usa: Calley Court Martial (1970)
Usa: Calley Ends Testimony And Defense Rests In Calley Court Martial. (1971)
Usa: Senator Kennedy Comments On The Calley Verdict (1971)
South Vietnam: Men Of Calley's Old Division Comment On Verdict (1971)
Usa: White Houses Announces Nixon Will Make Final Decision In Calley Case. (1971)
JOHN ERLICHMAN, SPECIAL PRESIDENTIAL ASSISTANT SPEAKING. SAYS THAT PRESIDENTIAL INVOLVEMENT IS ENTIRELY DISCRETIONARY IN VIEW?
South Vietnam: United States General Arrives In Saigon To Head Inquiry Into Pinkville Massacre Allegations. (1969)
LIEUTENANT GENERAL WILLIAM R. PEERS ARRIVED IN SAIGON FROM WASHINGTON YESTERDAY (SUNDAY) TO HEAD AN?
Usa: Congressman Announces Ad Hoc Hearings To Investigate War Crimes Responsibility. (1971)
Democratic Representative Ronald V. Dellums announced yesterday (Tuesday) in Washington that a Congressional group has?
Usa: Black Militants And Anti-War Supporters Demonstrate Outside White House (1971)
Some 700 Anti-Vietnam demonstrators - most of them militant Blacks - marched to the White House in Washington yesterday (Saturday), chanting "Hell No, We Won't Go", and carrying placards demanding the U.
U.S.A.: Captain Medina Denies He Is Responsible For My Lai Incident (1970)
UNITED STATES ARMY CAPTAIN ERNEST MEDINA DENIED ON WEDNESDAY (1 APRIL) A CHARGE -- MADE ONLY A FEW HOURS EARLIER -- THAT HE WAS RESPONSIBLE FOR THE PREMEDITATED MURDER OF ALL SOUTH VIETNAMESE CITIZENS ALLEGED TO HAVE BEEN KILLED IN THE MY LAI INCIDENT IN MARCH, 1968.
Usa: Vietnam Veterans Camp In Washington Park To Prepare Series Of Anti-War Demonstrations (1971)
A group of Vietnam war veterans, calling itself the "Vietnam Veterans against the war", has camped in a park within sight of the Washington monument in the U.
South Vietnam: South Vietnamisation In The Central Highlands Going Slowly And Carefully. (1971)
According to United States officers, the programme of Vietnamisation is going well, with only small points to be ironed out.
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Features April 13, 2017
Holy Sex is Obinna Udenwe’s New Novella About the Nigerian Church as an Erotic Space
We are delighted to bring you a new and exciting work of fiction: Holy Sex: A Nigerian Church Erotica by Obinna Udenwe. Holy Sex is Brittle Paper’s first foray into the world of book publishing—well, e-book, at least for now.
Holy Sex is a dark and humorous tale that breaks the silence around the Nigerian church as an erotic space. The novella chronicles the sexual exploits of Pastor Samuel, the General Overseer of Saving Grace, Inc.— a new generation Pentecostal church in Lagos. Pastor Samuel is rich, charismatic, and handsome. But when he isn’t delivering inspirational sermons, performing miracles, and winning souls for the Lord, he is engaged in all manner of illicit relations with female congregants, who he abandons the moment the relationship becomes inconvenient. Well, that’s until he meets a young woman who is bent on taking revenge and bringing him down.
The work is relatable in ways that hit close to home. The Nigerian media has repeated been rocked by high-profile scandals exposing the erotic underbellies of new-generation, mega churches preaching prosperity ministry while amassing huge amounts of wealth. Udenwe uses these real-life events as inspiration for a part delicious, part disturbing story about sex in the House of God.
The story is told as a direct address to the reader in an easy, gossipy, and conversational style. It is addictive and might shock the faint-hearted. In the masterful hands of Udenwe, award-winning author of Satans and Shaitans, the urban African church is imagined as a territory of forbidden desire where illicit sex intersects with faith to create a space rich for storytelling.
Publishing this work has been a rewarding journey. The project started out as a short story that we published in 2013. In Two years later, it became a popular series. After a 100,000 hits, we were convinced that the series could take on a new life as book. The partnership with Okada Books has been a key part of this transition. Their impressive reading app ensures that the work is available to African readers, which was important to us from the very beginning.
Holy Sex is available for download on okadabooks.com and amazon.com
Tags: erotica, holy sex, Home, nigerian fiction, Obinna Udenwe, religion
The Lunatic | By Barnabas Ikeoluwa Adeleke | Poetry
Nnedi Okorafor, Igoni Barrett, Tendai Huchu, Lesley Nneka, Ntone Edjabe Lead Inaugural Nommo Awards Shortlist of 19
3 Responses to “Holy Sex is Obinna Udenwe’s New Novella About the Nigerian Church as an Erotic Space” Subscribe
Davinson April 13, 2017 at 2:07 pm #
I was one of the early readers of Holy Sex series and deeply excited that I can read all of them now.
This is great.
Ainehi Edoro April 14, 2017 at 11:49 am #
@Davinson,
Thanks so much for your support!
Eze, Monday April 30, 2017 at 6:57 am #
A timely book with the potency of exposing and correcting the sexual and other moral rots in the modern churches.
Congratulations, Obinna Udenwe.
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BubbleStream
Geraldine Birch
a book bubble about
Sedona: City of Refugees
Set amid the scenic red rock beauty of Sedona, Arizona, Sedona: City of Refugees is the story of a widowed middle –aged newspaper reporter searching for God and herself amid the rubble of her life. Kathleen Sullivan Buckley writes profiles for a small newspaper about various characters that inhabit the tourist community. Running parallel to her articles is Kathleen’s own story: She is a fallen-away Roman Catholic attempting to deal with her loss of faith; she feels spiritually buffeted by her married lover’s powerful born-again Christian beliefs and the persistent philosophies of the New Age that constantly swirl about Sedona This novel is a biting look at a modern-day American tourist community caught in the throes of change. Sedona—considered by many to be more stunning than some of America’s national parks—draws more than three million tourists a year. But beneath the surface splendor of the scenery, Sedona is torn by deep conflict, with each political and spiritual faction hustling their individual philosophy.
Geraldine Birch has been a newspaper reporter most of her life, having worked for various community newspapers in Southern California and Arizona. Her work included a ten-year stint as a free-lance writer for the Los Angeles Times. In 1991, she moved to Sedona, Arizona, where she worked as a reporter, editor, and political columnist for the Sedona Red Rock News. Birch’s political column “Gerrymandering,” was awarded a first place national award by the National Newspaper Association. Her writing has also appeared in the Arizona Republic, the Christian Science Monitor, Opium, Six Hens, and Fiction Attic Press. She is the author of three books, The Swastika Tattoo, a historical fiction; Vision of a Happy Life: A Memoir; and Sedona: City of Refugees, a fictional romance set in Sedona, Arizona.
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Author Insight
A Very Bad Day
Although there are parts of this novel that never happened, as I have mentioned previously, this funeral for my husband is recreated as truthfully as it happened. Yes, it was indeed a bad day.
Kathleen put her arm through Charley’s and held his rough hand. A carpenter by trade, his hand, despite the calluses, was the most soothing she ever felt. Kathleen confided in Charlie ever since she could remember, everything from her girlhood dreams of becoming a newspaper reporter to her sudden decision late in life to give up her career to marry Scott.
“I’m so glad you’re here.” Her hands were shaking.
Charley leaned over to Kathleen, avoiding the brim of her hat and looked into her eyes that were beginning to tear.
“Don’t cry, Kathy. He was nothing but a bastard to you. He’s not worth your grief.”
“I think that’s why I am crying. There’s so much, Charley, so much hatred and despair in me because of…of, you know! And now, you see how his friends, our friends, act like I was some kind of leper because I left him.”
“But it can only get better for you now. Just think, you won’t have to go through a bitter divorce, which you dreaded. He’s dead, caused by his own hand. You’re alive, and you have your whole life ahead of you.”
“God, Charley, what an optimist you are!”
He laughed softly. “I know. I wish you were too.”
At that moment, behind them, a woman moved into the pew next to Kathleen’s friends from the newspaper. A man from the Altar Society came over to notify her that the pew was reserved for Kathleen. Red-headed and in her mid-thirties, she spoke loud enough for everyone in the surrounding pews to hear.
“I don’t give a damn if this is reserved for her! I’m a good friend of the Buckley family and there isn’t any place else to sit!”
She spoke in a menacing tone as she pushed herself some space by planting her large purse between herself and Kathleen’s editor, Rebecca Adams, who was forced to move closer to a coworker.
Kathleen turned to see who invaded her reserved pew and quickly turned back, feeling as if she’d been knifed. The woman was one of Scott’s whores, Elizabeth Ashton, resplendent in black, as if she were the widow, not Kathleen.
Through years of habit, a quick prayer flew to Kathleen’s lips. “Dear God, please, get me through this! ”
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Football participation in Australia grows to record levels
There are now more than 1.8 million Australians participating in football, an increase of 13 per cent on the previous year, a Football Federation Australia annual football census has found.
Football Federation Australia Chief Executive Officer David Gallop AM said the census which takes in affiliated football participation shows a significant increase across all areas of the game including Futsal, School participation and a continued rise in the number of female participants.
“Our women and girls participation base continued to increase and provide one of the greatest growth opportunities for Football. International tournaments including the 2018 AFC Asian Cup, Women’s Cup of Nations and rebel Female Football Week have played a key role in driving new women and girls to our game, now boasting over 141,000 registered participants,” he said.
Mr Gallop praised Member Federations across Australia, Hyundai A-League and Westfield W-League clubs for their work in encouraging participation in the game.
“Our football clubs across the country are filled with volunteers that keep putting in countless hours to ensure football continues to flourish,” said Gallop.
The results of the annual census come after FFA conducted an audit of facilities with Member Federations which identified a $500 million facilities funding gap.
The Everybody’s game audit found football is being held back by inadequate facilities and in many areas across Australia, the sport has outgrown the facilities available to participants.
“We are calling on government to join with us to deliver improved facilities and programs which can help improve participation even further, drive gender equality, integrate new communities and deliver strong preventative health outcomes,” Mr Gallop said.
Head of Community, Women’s Football and Football Development, Emma Highwood said the new data on participation reveals football continues to attract, engage and retain more participants community clubs.
“The efforts and investment from our volunteers, coaches and referees ensure we provide participants with a positive experience, which is highlighted by a 72 per cent participant retention rate.
ALDI MiniRoos continues to be our marquee program and the leading junior introductory program within Australia, with over 227,000 boys and girls playing.”
“Further, we have increasingly leveraged our games greatest assets; the Hyundai A-League and Westfield W-League Clubs, to engage and connect with new markets. This is reflected with over 14% growth in school participation, community events and promotional experiences delivered by the clubs, as we focus on converting our football participation base into fans,” she said.
Ms Highwood said Football Federation Australia would continue to invest in opportunities to ensure football remains a diverse and inclusive game for all Australians through programs and tournaments specifically for CaLD communities, Aboriginal & Torres Strait Islanders and all-ability participants.
Are you playing Football in 2019? Sign up now at playfootball.com.au!
2018 Football participation highlights:
13% overall growth on 2017 participation
1.5% growth in outdoor affiliated participation
2% growth in Women & Girls participation
2% growth in ALDI MiniRoos
30% growth in other formats including Futsal and Social Football
11% growth in Schools participants including School programs and tournaments
To download the FFA 2018 National Participation Report, please click here.
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Tag Archives: geologist
The Quake (Skjelvet)
Oslo, meet Los Angeles.
(2018) Disaster (Magnet) Kristoffer Joner, Ane Dahl Torp, Katherine Thorborg Johansen, Edith Haagenrud-Sande, Jonas Hoff-Otrebro, Stig R. Amdam, Ingvild Haugstad, Ravdeep Singh Bajwa, Hang Tran, Tina Schel. Directed by John Andreas Andersen
Some of you might remember a Norwegian disaster movie called The Wave from back in 2015 in which a small town in the mouth of a fjord is hit by a massive wave that nearly levels the town. Well, one good Norwegian disaster deserves another, don’t you think?
Obsessive geologist Kristian Elkjord (Joner) is a broken man. After trying unsuccessfully to get government officials in the little resort town of Geiranger to take his warnings of an impending disaster seriously, 248 people ended up dead. Now two years later, he continues to live in Geiranger although his wife Idun (Torp) has left him and his college-aged son Sondre (Otrebro) has no time for him. Only his daughter Julia (Haagenrud-Sande) seems to have any gumption to spend time with her dad but he clearly suffers from raging PTSD and cuts short a planned visit because he simply can’t handle it.
]When a colleague dies mysteriously Kristian is piqued into looking into his studies. Consulting his friend’s raw data, he begins to suspect that his colleague was on to something – that Oslo is on the brink of suffering the repeat of a devastating quake at the turn of the 20th century and with dozens of glass skyscrapers dominating the graceful sideline it is a disaster (movie) waiting to happen. And when the family is put into jeopardy, it is Julia and not Sondre who puts them there. Fortunately, the couple only had two kids…
]Poor Kristian has become the Cassandra of Norway – nobody will listen to his dire warnings which of course all come true. After all, nobody wants to see a movie in which the lead scientist is taken seriously and his advice followed. But I’m pretty sure that nobody wants to see a movie in which a kid defies her parent’s orders to put herself – and eventually others – in danger either, but that’s what happens here. Kids are not known for acting calmly and intelligently in a crisis situation but there comes a time where I was hoping that Julia might be flattened by a crossbeam or something. Hope springs eternal.
]Joner does a good job of portraying Kristian’s precarious mental state. We know the geologist will act decisively and heroically in a crisis situation (because we’ve seen him do it before) but it’s good that an element of uncertainty is thrown in. Will the PTSD overcome his heroic impulses? Stay tuned.
As with The Wave, the special effects range from the solid to the spectacular. While the director preferred – either for budgetary reasons or personal preference but it doesn’t matter which – using practical effects wherever possible, the CGI when used is hella effective. There are also some fairly gruesome injuries/deaths in the film, one in particular which is of the type Hollywood films like to tease but never carry through. Here in The Quake you get to see it and there is a certain visceral satisfaction in it, even if the victim doesn’t particularly deserve their fate.
The story though is pretty much Disaster Movie 101 much like The Wave was. It follows the same formulaic steps and while those steps are accomplished competently, there isn’t much in the way of surprises here. Still, it’s fine entertainment if you don’t mind subtitles and bratty kids. If it doesn’t play anywhere near you during a limited theatrical run, it’s already available for streaming on most major sites.
REASONS TO GO: The special effects are very well done.
REASONS TO STAY: The plot is too formulaic and depends on children doing stupid things.
FAMILY VALUES: There is a whole lot of disaster imagery and destruction, some depiction of injuries and brief profanity.
TRIVIAL PURSUIT: Oslo did suffer an earthquake in 1904 that measured 5.4 on the Richter scale; seismologists have expressed concern that they are due for another even more devastating quake.
BEYOND THE THEATERS: Amazon, Fandango Now, Google Play, iTunes, Microsoft, Vudu, YouTube
CRITICAL MASS: As of 12/15/18: Rotten Tomatoes: 81% positive reviews. Metacritic: 68/100.
COMPARISON SHOPPING: Earthquake
NEXT: Becoming Iconic: Jonathan Baker
Posted in New Releases, VOD Review | Tagged Ane Dahl Torp, Cassandra, cinema, Cinema365, disaster movie, earthquake, Films, geologist, highway tunnel, hotel management, Katherine Thorborg Johansen, Kristoffer Joner, Magnet Releasing, movies, Norwegian cinema, Oslo ballet, Oslo dance rehearsal, PTSD, reviews, skeptical authorities, Skjelvet, The Quake | Leave a reply
The Wave (Bølgen) (2015)
New Wave in Norway.
(2015) Disaster Action (Magnolia) Kristoffer Joner, Thomas Bo Larsen, Ane Dahl Torp, Fridtjov Såheim, Jonas Hoff Oftebro, Laila Goody, Arthur Berning, Eili Harboe, Edith Haagenrud-Sande, Lado Hadzic, Tom Larsen, Herman Bernhoft, Mette Agnete Horn, Silje Breivik, Håkon Moe, Tyra Holmen. Directed by Roar Uthaug
America has essentially had the monopoly on disaster movies. That doesn’t mean that America has the monopoly on disasters – they happen everywhere, all the time. It has been a long time coming that a good disaster movie comes from somewhere not flying the stars and stripes.
Norway’s fjords are lovely, but they are also a ticking time bomb. They are in a mountainous region, and when the set up is just right – as in the tiny tourist village of Geiranger which sits at the mouth of the fjord bearing it’s name – that time bomb can tick rather loudly. As the movie notes in a kind of prelude, rock slides from Ȃkneset Mountain back in 1905 impacted the river below, causing a gigantic wave 240 feet tall moving between two tall cliffs like a bullet through the barrel of a gun, a gun pointed right at Geiranger. Scientists are wary that similar circumstances will happen again.
For that reason, a monitoring station is set up there, and geologist Kristian (Joner) has been a part of the team that has kept an eye on the mountain. However, the lure of corporate money has gotten him and he is leaving the government-run station for the deep pockets of an oil company. His last day has arrived and he and his family – wife Idun (Torp) who works as a desk clerk at the town’s luxury hotel, disaffected teen Sondre (Oftebro) and cute-as-a-button 7-year-old daughter Julia (Haagenrud-Sande).
While station chief Arvid (Såheim) is none-too-happy to be down such a valuable member of the team, he nonetheless gives Kristian a nice send-off. However, readings that show the ground water disappearing suddenly in two sensors on the mountain send Kristian scrambling to examine the evidence, which is disturbing but not enough to have Arvid evacuate the town, especially at the height of tourist season.
Still, something about it bothers Kristian so when he’s just about to drive aboard the ferry, he whips a quick U-turn and heads back. While his suspicions still aren’t enough to get Arvid pushing the panic button, he has succeeded in stranding his family (Idun had been set to finish out the month at the hotel anyway) in the town. With the mountain rumbling, disaster movie fans know that the worst is about to happen. As is true with most disaster movies, who lives, who dies – and what is left of the town – is all up in the air.
Given the film’s small budget, the special effects are pretty impressive. Something with a budget north of $100 million might have made a more realistic looking wave (and it appeared that the filmmakers used practical effects whenever possible) but not much more realistic. When it comes bearing down on the audience, one wishes that the movie had been shot in 3D. That might have been one of those rare instances where the format would have made sense rather than being a gimmick inserted into the movie for the sole purpose of allowing theaters to upcharge the public for the privilege.
Joner, who recently appeared in The Revenant, has a good deal of screen presence and makes a likable hero, even though his workaholic ways and detail-oriented personality drive his family and colleagues crazy. His fierce devotion to his family doesn’t particularly make him unusual among disaster movie heroes but it is unusual to see this kind of character in a European film. Then again, it is unusual to see this kind of subject in a European film.
I had to feel badly for Oftebro, who plays Sondre. He plays a character who is about as disagreeable as you can get and will even irritate Millennials. Apparently, the writer doesn’t think very highly about teens; Sondre is grouchy, disrespectful, self-centered and prone to doing the wrong thing at exactly the wrong time. His actions get people killed and put his family in jeopardy; to be fair he does feel bad about it later but while he’s doing those things, you might be tempted to punch him right in the face.
Overall, I was a little bit disappointed in the movie; sure, the effects are better than I expected and the acting was solid, but there are so many disaster movie cliches and scenes that are literally ripped off from other movies such as The Abyss, Dante’s Peak, Jaws and The Impossible. Still, if you haven’t seen those movies and aren’t particularly familiar with the disaster genre, it will all be new to you.
So what this adds up to is a solidly entertaining European take on what has been up to now a genre dominated by American movies. Surprisingly, it is not essentially different than the American take on the genre. In a way, it is kind of comforting to know that some things are the same everywhere in the world – disaster movies apparently being one of them.
REASONS TO GO: Impressive but low-budget special effects. Joner is an effective and charismatic lead.
REASONS TO STAY: A lot of disaster movie cliches. You will want to punch Sondre in the throat.
FAMILY VALUES: Some graphic images of a tsunami disaster, and a few profanities.
TRIVIAL PURSUIT: Norway’s official entry for the 2016 Academy Awards Best Foreign Language film award; it didn’t make the final list of five however.
CRITICAL MASS: As of 3/15/16: Rotten Tomatoes: 80% positive reviews. Metacritic: 68/100.
COMPARISON SHOPPING: The Towering Inferno
NEXT: Zootopia
Posted in New Releases | Tagged 1905 tidal wave, Ane Dahl Torp, Bølgen, bomb shelter, cinema, Cinema365, CPR, disaster action film, Ȃkneset, family separation, ferry, Films, fjords, flooding, Geiranger, generator, geologist, High Ground, hotel front desk clerk, Kristoffer Joner, Magnolia Releasing, movies, moving, Norwegian cinema, oil company, reviews, rock slides, rockslide, sensors, skateboard, teen angst, The Wave, Thomas Bo Larsen, tourist attraction, traffic jam | Leave a reply
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“You will go back to your own life…
Posted on April 27, 2019 by Catherine Keefe
I’m on a quest to intentionally incorporate one simple act of kindness into each day for one year. My hope that kindness can change the world feels a little like throwing a glass ball into the ocean and believing it won’t break.
You can call this series: 365 Reasons to Roll Your Eyes, but science says your own happiness will increase if you share the journey.
“You will go back to your own life, but what will happen to me?” This simple question, asked years ago by a young boy, haunted a poet / editor friend of mine and ultimately inspired her to publish Collateral Damage, a benefit poetry collection dedicated to children impacted by trauma.
I first met Ami Kaye, that poet and editor, shortly after I embarked on my dream of creating dirtcakes, a literary journal.
“Exceptional works to replenish the spirit.”
This mission statement of Glass Lyre Press, Ami’s publishing imprint, inspires me. It resonates with my own reasons for wanting to get into publishing, what I hope to accomplish every time I sit to write: “to replenish the spirit.”
I sought out Ami at a writer’s conference in Los Angeles to ask her advice for running an independent literary press, which means one with no institutional financial support. Ami graciously encouraged me, then painted a picture of how at publication time she rallies a small group of volunteers around her dining room table in Illinois. They make editorial decisions about which literature will further the mission of the press, design covers and interior typesetting, diligently proofread galleys, hand package the books and magazines to be sent out to readers. Finally, someone volunteers to drive the batch to the post office.
All for the love of the word.
For so many creatives – writers, artists, musicians – and the people who promote their work, getting art out to humanity is a gesture of kindness. My lasting impression after first meeting Ami Kaye was that she’s a woman who leads with her heart.
So I wasn’t at all surprised when I learned to she was putting together a benefit anthology titled Collateral Damage.
“This benefit anthology seeks to raise funds for children with basic survival needs, for programs that protect and educate children, and foster child advocacy. This book will highlight children caught in the crossfire of war and political strife, adult ambition and greed. It will also address the transformative power of love and care. As current custodians of this world we need to protect the future: our children. Only if we work together can we harness the strength to speak up for those not allowed a voice; turning away is not an option anymore.”
I consider myself fortunate to now hold Collateral Damage in my hand. It includes two of my poems alongside powerful work from many of my poetry heroes. Not surprisingly, one of my poems is about sharing bread.
Putting precious resources of time and money into a book of poetry as a response to war, famine, abuse, injustice and healing might seem like a small, insignificant act of defiance.
But guess what? Counterintuitively, it may be one of the most effective ways to combat psychic numbing to trauma, whether personally experienced or witnessed through media, by offering our human psyches specific imagery, which is one of the superpowers of poetry. And that’s intriguing considering that the National Endowment for the Arts just reported poetry reading is on the rise, at its highest levels since shortly after 9/11/01.
Poet Naomi Shahib Nye offers insight into how poetry has the ability to uniquely connect humanity in an often quoted essay which appeared on Oprah.com in early 2002.
“Apparently, the entire United States has taken to reading more poetry, which can only be a good sign. Journalists ask, “Why do you suppose people are finding strength in poetry now?” Those of us who have been reading poetry all our lives aren’t a bit surprised. As a direct line to human feeling, empathic experience, genuine language and detail, poetry is everything that headline news is not. It takes us inside situations, helps us imagine life from more than one perspective, honors imagery and metaphor—those great tools of thought—and deepens our confidence in a meaningful world.”
The allure of poetry, of its ability to find a way “inside situations” and create an impact makes sense according to research on witnessing reactions to wide scale trauma by Paul Slovic, PhD, founder and president of Decision Research, a non-profit organization investigating human judgment, decision-making, and risk. Dr. Slovic has invested much of his career trying to understand why epic tragedies like mass genocide, climate change, refugee crises, create numbing among witnesses rather than mass action.
In a 2018 interview with science reporter Brian Resnick in VOX, Dr. Slovic broke down some key findings:
“People care about individuals. We see it over and over again: There’s a child who needs an operation, his parents can’t afford to pay for this operation, and there’s a story in the newspaper. An outpouring of money donations and support is often tremendous. We do care a lot about individuals. We don’t scale that up, even when we’re capable.
“Individual stories and individual photographs can be effective…they get us to see the reality, to glimpse the reality at a scale we can understand and connect to emotionally. But then there has to be somewhere to go with it.
“These…stories of individuals…give us a window of opportunity where we’re suddenly awake and not numbed, and we want to do something. If there’s something we can do, like donate to the Red Cross, people will do it. But then if there’s nothing else they can do, then over time that gets turned off again.”
So here, in Collateral Damage, are poems, “stories of individuals.” One poem, “An Interdiction Forbidding Mourning: Tehran, 2009” by Susan Fox, is dedicated to “Neda Sultan Agha, shot by a sniper for not wearing a chador.” Another, “The New Breed” by Alison Letterman is “For Emma Gonzalez and the other student activists” who are protesting gun violence. The collection holds heartbreak and paths to redemption.
After I received my contributor copy of Collateral Damage, I sent Ami Kaye a few questions via e-mail about the back story of the anthology and her hopes for its future. She graciously responded for you, dear readers.
What inspired this anthology?
During an undergrad semester I worked at a blind school and struck a friendship with a teenage boy. After the day’s lesson I shared stories and poems, he sang songs and told me of his dreams. On my last day he was withdrawn and refused to speak to me. After some prodding he burst out, “You will go back to your own life, but what will happen to me?” His words always stayed with me and I became very conscious of the plight of children. After I became a parent, I was even more aware of the staggering problems facing children, and while I was involved in various ways over the years, I did not have the means to do much. Now with the energy and talent of so many wonderful people, I hope we can do more.
In what ways did the project exhaust or energize you?
The sheer volume of correspondence, reading and selecting work, and the production logistics were daunting, but the response from the literary community warmed our hearts. I think that kind of enthusiasm, the shared dedication, and most of all, the thought of the children energized everyone working on this multi-dimensional project.
What did you have to say “no” to in order to say “yes” to this project?
We did not say no to other projects so last year was difficult for all of us. We ended up with a four-month backlog that has spilled into this year, but we think it is worth getting this project off the ground.
Was there a poem (or more than one) that made you cry?
There were several poems that hit me in the gullet. Some poems were powerful, some arresting, some with vivid visuals, but all had components that bolstered the cause. Taken as a whole, the book gives a voice to those rarely allowed one. I know readers will find a number of poems that speak to them.
Who deserves a shout-out for making this a reality? (I see Tracy McQueen, Steven Asmussen, Linda E. Kim, and Karen Bowles’ names on the front matter. Anyone else? Do you care to say a small detail about something one of them did that made the project as beautiful as it is?)
Steve deserves the lion’s share of praise for production, but Linda Kim and Karen had the painstaking job of copyediting. Karen especially, while wrestling with health issues and an evacuee from the recent California wildfires, somehow found the energy to participate in this project. Tracy’s stark cover art is a wordless poem. Most of all, each and every one of our authors and submitting poets deserves a shout out for their dedication to this cause. That kind of sincerity and emotion humbles me and gives me hope.
Is there one specific organization that will benefit from the proceeds? What impact do you imagine it will have?
We were originally thinking of UNICEF, or we’d like to try an organization more likely to allot a greater percentage of funds directly for the children. We are thinking of Shriner’s Children’s Hospital, and a few others. Please email amikaye.pf@gmail.com with any other suggestions.
Obviously our first hope is to raise money for the children, but sometimes impact comes in unforeseen ways. I hope people will read the heartrending poems and be moved to spread the word and raise awareness for programs that benefit and foster child advocacy.
I’m deeply grateful for all the work that Ami and her team at Glass Lyre put into Collateral Damage and all her other projects.
So, I’m spreading the word. And I’m cheating a little with one of my self-set rules for this Year of Kindness: Don’t use monetary donations as an act of kindness.
I bought three issues. But I’m giving myself a pass because I want to share these three issues with you, especially if you run a writing program where you tackle issues of trauma. If you want a free gift issue of Collateral Damage , please send me an e-mail using the form on the sidebar to your right telling me a little something about why you would appreciate this particular volume.
Then go read some poetry. National Poetry Month is in its waning days, but our psyches thrive on the images, the music, the human connection that poetry gifts us with, and that in turn gives us more inner fire to be kind.
Light the world with kindness,
Posted in #kindinkind, 365 Days of Kindness, Inspiration, poetry, What are you reading? | Tagged Ami Kaye, Catherine Keefe, Collateral Damage, Glass Lyre Press, Inspiration, Kindness, Naomi Shahib Nye, National Poetry Month, NEA Poetry Report, Paul Slovic, poetry | Leave a reply
Question: The edge
I’m embarking on a new adventure: to intentionally incorporate one simple act of kindness into each day for one year. My certainty that kindness can change the world feels a little like throwing a glass ball into the ocean and believing it won’t break.
“This one appeared to me
What a spring to discover one unexpected aspect of this Year of Kindness: It’s impossible to walk through the world without intent attentiveness: To my family. My friends. To the check-out guy at Trader Joes who thanked me for pointing out what a glorious day it was when he said he woke up feeling cynical and sad with the the world. And to the sky flood of bright orange painted lady butterflies which one incredible March day streamed past me in an endless field of poppies while I stood open-armed, smiling in the midst of their silent migration, which by some estimates numbered in the millions.
I lived through the Trabuco Canyon drought, the brown days and orange fires. And just like that, with a little respite in the form of plentiful rain, I walk through a wonderland this spring learning to name the flowers. Wild hyacinth. Whispering bells. Mariposa Lilly. Lupine.
Super Bloom expands for miles in such unimaginable scope it’s impossible to photograph the sweeping hillsides in a way that translates their wonder. So I focus close. One kind act. A blooming purple wild chia. One golden poppy stem.
A gray grasshopper on my back deck.
The grasshopper reminds me of the opening lines of Lawson Fusao Inada’s poem, “This One, That One.”
in a dream, was forgotten,
only to reveal itself
on the shower wall
It must have been the water.
That one was on the full moon
last night, clear as a bell.
Someone projected it there.
Something about the ordinariness of the gray grasshopper, especially in this extraordinarily colorful spring makes me wonder, how do you draw the line between the sacredness of this thing or that? Between this person or that one?
One living grasshopper (Schistocerca nitens) pauses on a now-dead hewn piece of ironwood (Tabebuia ipê) sawed into lumber planks for a deck. Both are listed in the Catalogue of Life, “the most comprehensive and authoritative global index of species… essential information on the names, relationships and distributions of over 1.6 million species…compiled from diverse sources around the world.” There are no borders in the Catalogue of Life .
This gray bird grasshopper, also known as a vagrant grasshopper, can be found in most of the Southwest US, Hawaii, and parts of Central America. The ipê is indigenous to many countries including Argentina, Bolivia, Brazil, Colombia, French Guiana, Guyana, Paraguay, Peru, Suriname, Trinidad and Tobago, and Venezuela. Yet both ended up in my backyard where there appears to be plenty of room. My backyard isn’t full.
How do we name the edge, the border between this thing and that, when nature herself has no walls?
That one speaks to me
of space, and negative space,
of open and filled spaces,
and the among
that comes between.
This year I’m dwelling in the “open and filled spaces, and the among that comes between.” My #KindInKind acts have taken a deeper turn from bread baking and letter writing, although to date I’ve delivered more than a dozen loaves accompanied by time for conversation and I’ve sent almost 20 hand-written notes. I’m delving into things that keep us humans from being kind; I’m studying with those who work toward commonality rather than exploiting differences.
Last week I attended one of a series of community forums sponsored by the Orange County Interfaith Network, a group whose mission is to “present united faith-based responses to social justice issues, while encouraging respect, civility and the common good.” The theme of the forum was “The more you know, the less you fear.” University students representing eight different spiritual traditions – Eclectic Pagan, Roman Catholic, Interfaith, Muslim, Christian Church Disciples of Christ, Conservative Judaism, Agnostic, and Bahá’í – shared spiritual experience narratives and created space for dialogue with dozens of community members.
Caroline Kutschbach, President of the Chapman University Religious Honors Society, articulated what could have been a summation of the evening. “It’s my goal to teach people to be more understanding of one another. You may see me as your ‘other,’ but I see an ‘I’ in all of us. All faith trails can lead us to the same peak.”
I’ve walked up many peaks this spring but not on the only trail. I may not have a traditional faith practice, but I came away from that evening with incredible faith in our future, in the way some young people face differences with curiosity, respect, open hearts and open minds, consciously trying to find common ground with one another rather than building walls. We are living proof that it’s possible to embody kindness in the same spirit the Dalai Lama, expresses in his Policy of Kindness.
“This is my simple religion. There is no need for temples; no need for complicated philosophy. Our own brain, our own heart is our temple; the philosophy is kindness.”
If you’re inspired to consider why it’s kind work, urgent work, to question boundaries and edges, read the entire poem that my grasshopper find called to mind.
“This One, That One” comes from Lawson Fusao Inada’s book, Drawing the Line, about his experience from ages four to seven in an internment camp. He was one of the youngest Japanese Americans forced to relocate during WWII after President Franklin D. Roosevelt signed Executive Order 9066 in February, 1942. The order mandated immediate incarceration of all Americans of Japanese ancestry, roughly 120,000 humans, the majority of which were American citizens.
Inada’s poem, his book, questioning the human edge between this one and that one seems especially right for exploring what kindness must mean in America these days and why it feels like the most important practice to focus on this year.
Here’s to trying to lose our rough edge through kindness.
Posted in #kindinkind, 365 Days of Kindness, Inspiration | Tagged #kindinkind, Catalogue of Life, Catherine Keefe, Japanese Internment Camp, Kindness, Lawson Fusao Inada, National Poetry Month, Orange County Interfaith Network, Superbloom | Leave a reply
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Nobody asked; just my opinion.
life:examined + mind:expanded + hearts:opened + people:engaged
Are you living before you die?
Happy happy first day of Autumn!
Fuse Books Interview: Heather Cox Richardson on the History of the Republican Party — Going Full Circle
If I Have Gay Children: Four Promises From A Christian Pastor/Parent
Ferguson on my mind
Why can't we just get along?
Tag: Black
How do you reconcile what is happening in Ferguson, MO with the fact that it is 2014 and not 1963 in Birmingham, AL? Or Shelby, NC?
On August 9, 2014, at approximately noon,after a confrontation and possibly an altercation, a white police officer, Darren Wilson fired his gun six times and killed an unarmed black teenager, Michael Brown, in Ferguson, MO, a predominantly black suburb of St. Louis. Beyond these accepted facts, there is nothing but looting, protests, teargas, rubber bullets, camouflage gear, Kevlar vests and helmets, armored, IED mine-resistant military vehicles, assault rifles, sharp-shooters with mounted automatic weapons, and lots of confusion. I’m just waiting for the water-canons and attack dogs to arrive from the Birmingham Police Department.
But this is not the end of the story. It is the beginning of a horrendous situation involving initially peaceful protests that have devolved into violent and hateful confrontations between looters, angry protesters, members of the press, local, county, and state police, and the National Guard. Everyone and everybody has jumped into the public opinion circus ring: the coroner, the District Attorney, the Police Chief, State Police Captains, the Mayor, the Governor, the President, news outlets, pundits, reporters, the family and friends of the victim, and even the girlfriend of the “officer’s significant other”. Oh, and did I mention, Amnesty International arrived yesterday?
I think back to growing up in Shelby in the Sixties, a small, tightly knit, textile mill town in the Piedmont. It seemed almost everyone worked either for the Dover’s in one of their mills and lived in the Mill Villages, Fiber Industries, other small weaving, spinning, or dyeing mills, or PPG Industries with fiberglass. Both my Mom and my Dad worked, and worked hard with different shifts. I recall my Dad trying to keep me away from Mom during the days when she worked third shift, Mom taking her turn at the challenge for Dad to sleep as well.
Eventually, not sure whether from desperation or lack of sleep, or both, my parents got someone to care for me. My Mom eventually working “days” made this a necessity. In the south, in the Sixties, in a white household, that meant a black lady. Yes. That’s right. Think: “The Help.” Four boys, 3, 12, 16, and 17, with two, hourly wage earning parents, The first caregiver/sitter/cook/proxy-Mom I recall was Miss Betty. Her hallmark was to always, always wash me up good and put me in clean clothes before Mom came home. No exceptions. That cleanliness exercise in the afternoons, and the fact that she loved to snuggle me on her lap with her starched apron encompasses and completes “Miss Betty” for me.
My next black lady experience was with Eula Mae Black. No “Miss.” Just always Eula Mae. It was actually a package deal, or maybe a tag-team bout. Eula Mae would get dropped off early in the mornings by Aunt Josie in a huge, pink, four-door beast of a car–perhaps a Cadillac or a Buick. At some point during most days, Aunt Josie would swing back by. Sometimes all three of us would go to “town.” I remember great shopping trips to Rose’s or Woolworth’s 5 & 10. Ham biscuits at the lunch counter, served by other equally loving, smiling black ladies, with aprons, of course.
Sometimes my excursions included cleaning up churches on Monday’s I presume, after Sunday services. That was probably, actually my first “job.” Aunt Josie would assign me the job of going up and down every pew, picking up the discarded church bulletins. I would stack them, align them, and pretend to count them. Then, I would turn in my harvest to one of them after they finished dusting. They never let me use that great-smelling furniture oil, but I recall the scent and the softness of their hands afterwards.
One other excursion I recall with great fondness was when I got to go to their house on the other side of town, past the hospital, down Grover Street into the colored side of town–as it was known. I had the most fun playing with all the kids that seemed to always pop up there. I loved it. Great memories. I played. I ate. I had friends.
Later, in 1966, as I started school I remember some black students in class, but they were always the smallest group, yet always at least one or two in every class. Oh, there were blacks at the school, but they were in the back of the kitchen, behind the serving line, or rolling about the halls with trash cans on wheels and long-headed dust mops. Evans and Ray, the janitors at my elementary school were somehow my friends–they surely must have known Aunt Josie and Eula Mae, and seen me playing there. As for my other black playmates, I now realize their absence was the result of segregation. And their slowly increasing presence was the result of court cases and judicial decisions that lead to the desegregation of public schools. As I reflect now, I am not certain North Carolina was really working “with all deliberate speed” to bring those black playmates into Graham Elementary School. I never started to see any of those kids I played with at Aunt Josie’s until I was a high school student.
Fortunately, I never remember Shelby using dogs and fire hoses to deal with desegregation. There were no armored vehicles, assault rifles, or tear gas. There was certainly tension, and leaders from both the white and black community seemed like they were working on it. Rev Sam Raper, a prominent black preacher was always trying to bring folks together. One of our mayors, Les Roark worked tirelessly with Rev. Sam, and a host of other players to keep things from boiling over in Shelby. They appointed me to serve on the city’s Human Relations Council, and later, a Youth Council. I imagine the purpose was to open dialogue between blacks and whites, including youth.
Admittedly, Shelby had significant racial issues seething just below the surface during its history, up through the present. It was home to a large Ku Klux Klan group. It was where Thomas Dixon, the writer of The Birth of a Nation, and its controversial film, as well as other unabashedly racist novels, operated at the beginning of the 20th Century. The KKK has been recruiting in Shelby as recently as the Spring of 2013. I don’t pretend to ignore or gloss over these issues. If Birmingham was the front lines in the early Sixties, and other places in the South saw significant battles for desegregation, I believe that Shelby was somewhere along the supply lines in this war, perhaps operating as the complete opposite of the Underground Resistance of WWII. These movements to resist integration and equality, hidden in plain sight, continued to supply the opponents with warmth, succor, and leaflets, along with legislation. Continue reading “Ferguson on my mind” →
By Chris D. Mitchellin Ferguson, Why can't we just get along? August 20, 2014 August 20, 2014 1,389 Words1 Comment
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Home > Oil and gas wastewater leaves radium in Pennsylvania stream sediments
Web Date: February 6, 2018
Oil and gas wastewater leaves radium in Pennsylvania stream sediments
High levels of radium found downstream of treatment plants years after fracking wastewater disposal reportedly ended
By Deirdre Lockwood, special to C&EN
News Channels: Environmental SCENE, Analytical SCENE
Keywords: Pollution, oil and gas, wastewater, radioactivity, radium, fracking, hydraulic fracturing
Radium levels in sediments downstream of plants that treat oil and gas wastewater, such as this site on the Allegheny River in Franklin, Pa., are up to 650 times as great as in upstream sediments.
Credit: Avner Vengosh
Despite a 2011 Pennsylvania guideline curbing the discharge of wastewater from the hydraulic fracturing, or fracking, industry to water treatment plants, high levels of radium are still settling in some of the state’s stream sediments, according to a new study. The results suggest that some treatment plants that process wastewater derived from conventional oil and gas production are releasing this carcinogenic radionuclide. In some sediment samples, the radium activity reached 25,000 becquerels/kg, about 14 times as great as the threshold at which some states require solid radioactive waste to be disposed of in a licensed facility (Environ. Sci. Technol. 2018, DOI: 10.1021/acs.est.7b04952).
During both fracking and conventional oil and gas production, saline water enriched in naturally occurring radionuclides is extracted from rock formations and flows to the surface as wastewater. In Texas, Oklahoma, and many other oil and gas producing regions, operators dispose of this wastewater by injecting it into deep wells. But in Pennsylvania, where the Marcellus Shale formation has supported a fracking boom, the underlying geology precludes deep well injection, says Duke University geochemist Avner Vengosh.
Treatment plants in Franklin, Creekside, and Josephine, Pa., receive wastewater from conventional oil and gas drilling of the Marcellus Shale.
Credit: Environ. Sci. Technol.
As a result, some of this wastewater in Pennsylvania has been shuttled to treatment plants to remove contaminants and then released into local streams. Because of public concerns about high levels of bromide in fracking wastewater, which can be transformed into harmful disinfection by-products such as trihalomethanes during wastewater treatment, the Pennsylvania Department of Environmental Protection asked fracking operators to stop sending wastewater to these facilities in 2011, and they have reportedly complied. But this request does not cover conventional oil and gas producers, who still send wastewater for treatment and release into some streams in the state.
Vengosh and his colleagues suspected that this source would also contaminate stream sediments with radium. So, from 2014 to 2017, they tested for it at three sites where streams receive this treated wastewater.
Near outflow pipes from the treatment plants, the researchers measured up to 650 times as much radium in the stream sediments as in sediments upstream. The overall levels of radioactivity in these sediments was similar to those the group previously found in sediments where fracking wastewater was being released, Vengosh says.
To determine the source of the radium, the researchers took advantage of the chemical difference between wastewater produced by fracking and that produced by conventional oil and gas production. The predominant radionuclide in wastewater from fracked, uranium-rich shale is 226Ra, whereas in sandstone and similar formations that are drilled conventionally, there are relatively equal amounts of 226Ra and 228Ra. The ratio of 228Ra/226Ra in the sediment samples indicates that the majority of the radium originates from wastewater from conventional oil and gas production, according to Vengosh.
The different half-lives of these isotopes and their daughter isotopes in the two types of wastewaters also help the researchers determine approximately how long the radionuclides have been in stream sediments. For example, 228Ra in conventionally drilled oil and gas formations eventually decays to 228Th. The 228Th/228Ra ratios in sediments suggest that the majority of the radium accumulated in the past three years, since fracking waste disposal in these streams is said to have ended.
Vengosh calls the levels of radium in the sediments “mind-blowing,” and found this especially surprising because wastewater treatment reduces radium levels by about 98%. The study suggests that even low concentrations of radioactivity in large volumes of treated water can generate a huge amount of radioactivity in sediments, he says.
Since the treatment and release of conventional oil and gas wastewater likely leads to this contamination, this practice should also be stopped, Vengosh says. Fracking wastewater is currently reused in fracking, or transported outside the state for deep well injection.
This contamination could spread beyond the stream sediments. Creatures living in streambeds can ingest the radium, and it can bioaccumulate, eventually showing up in fish. Wastewater from conventional oil and gas production, with its high salt content, is also sold as a road deicer in both Pennsylvania and New York.
Nicole Fahrenfeld, an environmental engineer at Rutgers University, calls the results interesting. She says the research raises questions about the fate of harmful constituents in these wastewaters—such as how far downstream elevated levels of radium persist, and whether sticking to sediments slows the spread.
These high levels of radium in sediments could come from infrequent pulses of wastewater with higher concentrations of radium, the authors note in the paper. Determining whether radium is slowly leaching into streams versus traveling in spurts will be important, Fahrenfeld notes. Engineers could use those insights to design more effective wastewater treatment technologies, she says.
Michael ferringer (February 11, 2018 1:02 PM)
I am a very avid fisherman in venango and mercer counties and occasionally warren. How long will it take to run these radium issues through to make my small local streams safe again to consume the trout I catch especially when camping?
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Infosys to come under big pressure after TCS share buyback
Tata Consultancy Services (TCS) announcing a buyback of up to 5.6 crore equity shares for up to Rs 16,000 crore will certainly put pressure on Infosys to also go for a buyback.
ET Online
February 20, 2017, 16:13 IST
Updated: February 20, 2017, 16:16 IST
Recently, there was speculation about Infosys planning a Rs 12,000 crore share buyback which the company had denied.
Infosys had liquid assets, including cash and cash equivalents and investments, worth Rs 35,697 crore (about $5.25 billion) on its books at the end of December 2016.
Former CFO of Infosys T V Mohandas Pai, along with former colleague V Balakrishnan, had sought a $1.8 billion buyback in 2014 just as CEO Vishal Sikka was taking over.
Referring to the idle cash with Infosys, Balakrishnan had recently said it seemed that Infosys had become a "finance company" rather than an IT company.
Pai too exhorted institutional investors to raise questions about the huge cash pile on the company's books.
Recently, Cognizant too announced a $3.4 billion buyback plan.
Main reasons behind a clamour for buybacks at the IT companies is that these companies have had only single-digit growth recently, leading to low shareholder returns. Shareholders can be rewarded through other means such as a buyback.
Cash is idling at Indian IT companies as they are neither making acquisitions nor investing in growth.
A buyback displays a company's optimism in future. It indicates the company's shares are under-valued. Buybacks are also more tax-efficient than dividends. They also help put a floor under the share price.
Mohandas Pai
3 months agoInfosys firm on stand, refutes charges of lapses
3 months agoAnother whistleblower guns at Infosys' Salil Parekh
3 months agoInfy-Bansal row closure good for the company: Analysts
3 months agoMoody’s downgrades outlook on SBI, HDFC Bank, Infosys, TCS and 10 others
3 months agoAsk almighty or Nilekani: Sebi chief on even God can't change numbers remark
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Governor Abbott Visits Friends of Zion Museum In Jerusalem
JERUSALEM - Governor Greg Abbott today visited the Friends of Zion Museum in Jerusalem, Israel. During his visit, the Governor was presented with the Friends of Zion Award, which recognizes global leaders who have courageously supported the nation of Israel and Jewish people.
This visit is part of Governor Abbott’s economic development trip to Israel and Switzerland.
Governor Abbott Attends Roundtable At Start-Up Nation Central Headquarters In Tel Aviv
TEL AVIV - Governor Greg Abbott today kicked off his economic development mission to Israel by visiting Start-Up Nation Central (SNC) Headquarters in Tel Aviv. The Governor met with leaders of SNC to discuss opportunities for Israel and Texas to collaborate on the advancement of the cyber security, energy, and robotics sectors, and discussed the growing technology sector in Texas - including the state's continued success as the number one technology exporter in America.
Governor Abbott Visits U.S. Embassy, Western Wall In Jerusalem
JERUSALEM - Governor Greg Abbott continued his first day in Israel by visiting the United States Embassy in Jerusalem, where he met with Ambassador David Friedman. The two leaders discussed the enduring friendship between Israel and Texas, and the Governor reaffirmed the Lone Star State's unwavering support for the Israeli people. The discussion concluded with an update on Texas' cornerstone plaque, made for display in the U.S. Embassy, that was unveiled in 2018.
Governor Abbott Meets With Israeli Prime Minister Benjamin Netanyahu In Jerusalem
JERUSALEM - Governor Greg Abbott concluded his first day in Israel by meeting with Israeli Prime Minister Benjamin Netanyahu in Jerusalem. The Governor and the Prime Minister discussed the long-standing economic and cultural bond between Israel and Texas, as well as ways to strengthen this relationship in the future. This is Governor Abbott's second time to meet with Prime Minister Netanyahu — the two leaders met in 2016 when Governor Abbott visited Israel for a previous economic development mission.
Governor Abbott To Lead Economic Development Mission To Israel And Switzerland
The Office of the Governor Greg Abbott today announced that the Governor will lead an economic development mission to Israel and Switzerland. The delegation will depart January 14, 2020 and return on January 24, 2020. During the trip, the Governor will tour businesses, hold meetings with public officials and executives, and participate in the World Economic Forum in Davos. This will be the Governor's second trip to both Israel and Switzerland.
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TINTON FALLS, NJ – Texas has been named Business Facilities’ 2019 State of the Year, becoming the firststate to win BF’s top honor for the fourth time. The Lone Star State won the magazine’s inaugural SOTY designation in 2007; Texas also was BF’s State of the Year winner in 2012 and 2016.
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Last week, discount brokerage firm Charles Schwab announced a $26 billion merger with TD Ameritrade. Coupled with this merger is a change in location: the combined company will relocate its corporate headquarters from San Francisco to Texas.
Governor Abbott Announces Expansion Of Microsoft Regional Hub In Irving
October 25, 2019 | Austin, Texas | Press Release
Governor Greg Abbott today announced that Microsoft Corp. will expand its operations in Irving, Texas, further establishing their Las Colinas site as a strategic regional hub in the area.
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May 19, 2008 / 12:17 AM / 12 years ago
Taiwan's new president means business - from China
Ralph Jennings
TAIPEI (Reuters) - Anthony Liao is hiring speakers of minor Chinese dialects at his Taipei travel agency, studying new destinations and ensuring a supply of buses as he gears for a surge of tourists from China, a relative rarity until now.
Taiwan's President-elect Ma Ying-jeou speaks during a news conference in Taipei in this April 14, 2008 file photo. REUTERS/Nicky Loh
His Phoenix Tours International Ltd. agency is just one of hundreds of companies, airports and local governments equipping themselves for closer ties with China under president-elect Ma Ying-jeou, who takes office on Tuesday.
“We have to prepare for the arrival of mainland Chinese, as they’ve got a different mentality,” said Liao. “Mainland China wants quality guarantees.”
His industry is awaiting a much-touted tourism deal that would open Taiwan to 1.1 million Chinese tourists per year and launch regular cross-strait flights, helping to jump-start the service sector.
Liao’s frantic, extensive preparations are typical of industries around the island, which are getting ready to receive Chinese property investors, currency traders and airlines if Ma fulfills his pledges to open trade links with China.
China has claimed sovereignty over self-ruled Taiwan since 1949, when Mao Zedong’s Communists won the Chinese civil war and Chiang Kai-shek’s Nationalists (KMT) fled to the island. Beijing has vowed to bring Taiwan under its rule, by force if necessary.
But a thaw in relations between the two sides over the past decades has led to heavy investment in China from Taiwan.
Lured by a common language, lower labor costs and a potentially huge consumer market, investors have poured an estimated $100 billion into the mainland.
The flow has been largely one way, however, with Chinese tourists and investors locked out of Taiwan due to tension between Beijing and outgoing President Chen Shui-bian.
Ma, who won by a landslide election victory in March on an economic revitalization platform, is pledging to put in place direct weekend Taiwan-China flights by July and allow up to 3,000 Chinese tourists in per day.
The roughly 750,000 Taiwan islanders with factories and other investments in China currently have to transit through Hong Kong or Macau, adding up to half a day onto their travel time.
Holiday-season charters began in January 2005, ending a ban Taiwan put in place after the civil war. But even those one-off flights must go through Hong Kong airspace, meaning many are roundabout and almost as time-consuming as making a transit stop.
BUSINESS DINNERS
Ma has also said he plans to make the Chinese yuan convertible with the Taiwan dollar, let Chinese buy Taiwan real estate and push for a common market.
“You can get the feeling from dinners that Ma has been attending that the private sector is very excited,” said Tony Phoo, an economist with Standard Chartered.
Chinese real estate developers are waiting in the wings, along with banks and local government mega-projects.
“Demand for the yuan will start to take off after flights become regular,” predicted Daniel Wu, chief investment officer of Chinatrust Financial, Taiwan’s top credit card issuer, which plans to partner with HSBC once conversions are legal. “We want to get prepared for that as soon as possible.”
In a possible sign of real estate deals to come, some China executives agreed this month to buy 12 high-end homes and a store for T$1.32 billion ($43 million) in the central city of Taichung.
The same city, Taiwan’s third largest, is leaning on Chinese investors to develop a 66-hectare service segment of its high-tech machinery park and has embarked on a T$1.5 billion expansion of its airport to accommodate new tourists and returning Taiwan investors, Vice-Mayor James Hsiao said.
Anticipation of traffic from China is also driving plans for a 6,150-hectare commercial centre next to Taoyuan International Airport, which serves greater Taipei.
Airlines on both sides of the Taiwan Strait have been allocating staff and aircraft to offer non-stop cross-Strait flights, with the top two domestic carriers, China Airlines and Eva Airways, both standing by.
Shanghai-based China Eastern Airlines has also been “in active preparation” for direct flights, said airline spokesman Luo Zhuping.
But fears that Chinese tourists will not like Taiwan, that Chinese investors will drive up property prices and that Ma’s pledges might fall flat lurk beneath the flurry of preparations.
Property prices have been rising steadily over the past two years as many anticipate a flood of new interest from China, raising concerns of a real estate bubble ahead.
Tour operators are also worried that a lack of preparation, such as a failure to provide sufficient mid-priced and budget hotels, could give Chinese tourists a bad impression.
Airlines dare not expand until Ma’s pledges materialize, an industry executive in Taipei said, noting talk that the new president may have promised more than he can deliver. “We want to first take step one before talking about step two.”
Additional reporting by Faith Hung in Taipei and Michael Wei in Beijing; editing by Doug Young and John Chalmers
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The S.C. Gallup Saddlery Co.
1908~Catalog No. 15
111-113 W. Fourth St.
Samuel Caldwell (Callie) Gallup was the younger brother of Francis Gallup. He learned his craft at the (F) Gallup and Gallatin Saddlery in Denver, Co. With the help of EL Gallatin, S.C. Gallup opened his saddlery in Pueblo, Co in 1869.
The SC Gallup and Co of Dodge City, Kansas was started in 1878 and managed by Robert E. Rice until 1880, when Rice assumed the the ownership and changed the name to the R. F. Rice Saddlery.
The SC Gallup and Co of Durango, CO operated from around 1881 to 1884. An employee of Gallup, Frank H. Young, worked in Durango under his own name from 1884 to 1897, although Gallup is thought to have been in the partnership with Young for those years.
Robert Thompson Frazier came to Pueblo, CO in 1880 and went to work for Gallup. In 1892 they formed a partnership that lasted until 1898. The SC Gallup and Frazier Saddlery logo was a longhorn steer saddled with a Pueblo style saddle and G.&F. branded on the left front shoulder. Samuel Caldwell Gallup died in 1904.
From 1905 to 1911, Judith Gallup was president and major stockholder. From 1912 and until his death in 1921, James Wimmer was president and major stockholder. The SC Gallup Co. was closed sometime between 1921 and 1924. The SC Gallup orders were filled at the Thomas Flynn Saddlery from 1924-1932.
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Convergence of Hormones, Inflammation, and Energy-Related Factors: A Novel Pathway of Cancer Etiology
Martha L. Slattery and F.A. Fitzpatrick
Martha L. Slattery
F.A. Fitzpatrick
DOI: 10.1158/1940-6207.CAPR-08-0191 Published November 2009
Colorectal cancer (CRC) is a multifactorial disease with several hypothesized etiologic factors including inflammatory processes; hormones such as estrogen, androgen, and insulin; and energy-related factors. We present evidence that integrates these elements in a pathway we call the convergence of hormones, inflammation, and energy-related factors (CHIEF). First, given the physiology of the gut, substantial epidemiologic and molecular data support the hypothesis that activation of innate immunity in the normal gut mucosa by various environmental agents (commensal bacteria, dietary antigens, mucosal irritants, pathogens) and endogenous factors such as estrogen, androgens, and insulin levels provokes basal inflammation as an underlying factor of the association of insulin, estrogen, and energy-related factors with CRC. Second, critical genes involved in this pathway, e.g., phosphatase tensin homologue on chromosome 10 (PTEN) and serine threonine kinase 11 (STK11)/LKB1, are tumor suppressor genes often mutated in intestinal cancer or CRC. Third, laboratory experiments show that cellular PTEN and STK11/LKB1 tumor suppressor enzymes are vulnerable to inactivation by redox-active species, especially chemically reactive lipid mediators of inflammation and redox stress. Epidemiologic data further support the underlying proposal that CHIEF comprises important elements of CRC risk. Although this discussion of the CHIEF pathway focuses on CRC, we believe that this pathway may play an important role in the etiology of other cancers as well.
energy-related factors
pathway convergence
Epidemiology is devoted to understanding the causes and distribution of diseases within populations. Cancer epidemiology has focused on associations between specific cancers and environmental, nutritional, behavioral, physiologic, and molecular and genetic factors. Observations from these studies have been central to our current understanding of the causes of cancer and our efforts to control cancer through public health policy, interventions, and translational research. Percival Pott's observation in 1775 that soot exposure led to a high rate of scrotal cancer in chimney sweeps likely gave birth to the concept of chemical carcinogenesis, which was validated in preclinical studies of 1918 proving that soot caused scrotal cancer in animals (the cancer link to polycyclic aromatic hydrocarbons in soot was made in 1938; ref. 1). Pott's observation led to important workplace measures for cancer prevention. The association between tobacco use and lung cancer is a more recent example of epidemiologic observations leading to public health measures to reduce cancer risk.
Not all associations between risk factors and cancer are as robust and singular as are the associations between chimney soot and scrotal cancer, or tobacco smoke and lung cancer. One of the challenges of contemporary epidemiology is to determine the common molecular processes through which risk factors operate. Epidemiologic observations of the present day emphasize the complexity of cancer etiology, comprising abundant data suggesting that cancers have multiple causes and usually both unique and overlapping risk factors. However, as in 1775, epidemiologic observations are crucial to our understanding of cancer etiology and continue to lay the foundations for cancer prevention and control.
In this review, we consider the associations of inflammation, hormones, and energy-related factors such as obesity, physical activity, and energy intake with colorectal cancer (CRC) and propose a mechanistic explanation for their convergent effects on colorectal carcinogenesis. We label our proposed pathway the convergence of hormones, inflammation, and energy-related factors (CHIEF) and provide epidemiologic and molecular evidence that supports the importance of this pathway to CRC. Although our discussion of the CHIEF pathway focuses on CRC, we believe that this pathway also may play an important role in the etiology of other cancers.
The Gut: A Lymphoid Organ Routinely Exposed to Inflammatory Stimuli
Inflammation, a core component of the CHIEF pathway, is an underlying feature of physiologic and pathologic processes that operate throughout the gut, particularly the intestinal tract and colon. Many pathologic aspects of gut inflammation, e.g., colitis, are well established and well understood. By contrast, physiologic aspects of inflammation are unknown and often not acknowledged. Conventional sources of inflammation—infectious pathogens and tissue injury—occupy one end of a continuum of pathologic processes that inaugurate inflammation. They disrupt vascular integrity and cause plasma proteins and leukocytes to accumulate at an affected tissue site, where they annihilate pathogens and eventually help restore morphologic and histologic integrity. Toward the other end of the continuum, tissue stressors or malfunction, such as premalignant lesions including adenomatous polyps, can provoke an adaptive response sometimes called “parainflammation.” This response may involve tissue-resident leukocytes (macrophages, eosinophils) and adjacent cells in the stroma (fibroblasts), and it is intermediate between the basal homeostatic state and a classic inflammatory response. Parainflammation is likely a major contributing factor to many modern human diseases including CRC. Parainflammation is inseparable from the role of the gut in human physiology.
The gut, particularly the large intestine, is one of the largest and most diversified lymphoid organs of the body (2) and is routinely exposed to immune and inflammatory stimuli. It contains gut-associated lymphoid tissues, mast cells, resident macrophages, lymphocytes, and eosinophils (3) in the lamina propria and submucosa of the intestine and colon (4), and specialized epithelial cells called M cells, which allow host immune cells to sample luminal antigens (5). All of these cells are close to the epithelial cells (colonocytes), suggesting that biochemical interactions between the stroma and epithelium could influence colorectal tumor progression. Basically, the gut mucosa and stroma are the first ramparts of a host's defense against swallowed matter, including bacteria, bacterial lipopolysaccarides, gut parasites, food antigens, particulates, chemical irritants, alcohol, dietary polyunsaturated fatty acids, carcinogens, and even certain drugs, which can activate innate and adaptive immune responses. Furthermore, anything that disrupts the mucosal barrier, e.g., ulcers or colorectal polyps (6), can expose the lamina propria to bacteria, exacerbate immune activation, and necessitate repair or replacement of cells at the affected site of the gut.
Once thought to be a host response against tumors, localized stromal inflammation may actually worsen cancer risk and progression (7–10). Eosinophils are inflammation-related leukocytes with a special capability to counter parasitic infections in the gut (3, 11), and mild-to-moderate eosinophilia occurs in the stroma of ∼75% of colonic adenomas (12). Neutrophils, another inflammation-related group of leukocytes, are occasionally found in colorectal polyps (13). Eosinophils and neutrophils also can cause tissue remodeling and wound healing, not just tissue damage such as that associated with polyps. It is possible that eosinophils and neutrophils mediate both cell destruction and normalization and recovery from inflammation, and are potentially important modulators of intestinal tumorigenesis; they are the first inflammation cell types recruited in response to proinflammatory cytokines. Mast cells are then activated, stimulating the proinflammatory cytokines and chemokines such as the interleukin (IL) family, IFNs, and tumor necrosis factors (TNF; ref. 14). Macrophages derived from monocytes that have infiltrated the inflamed area provide a network of growth factors, cytokines, and prostaglandins.
The inflammatory loci are further influenced by interaction with epithelial and vascular endothelial cells and are closely linked with angiogenesis, which involves the growth of new blood vessels from preexisting vessels. Both angiogenesis and inflammation are hallmark features of tumorigenesis as well as other diseases such as Crohn's disease, diabetes, and obesity (14), and have related molecular events. Inflammatory cells that have infiltrated tissue are one of the factors that stimulate angiogenesis; the vascular endothelial growth factor (VEGF) is known to play an important role in angiogenesis (15). Without the recruitment of blood vessels during angiogenesis, tumors are limited in growth and in their ability to metastasize (16). In animal models, it has been shown that inflammatory cytokines such as IL-1α and IL-1 β are required for angiogenesis and tumor growth (17, 18), whereas cyclooxygenase (COX)-2 acts both as an proangiogenesis and proinflammatory agent (19, 20).
Inflammatory processes seem to be a key element in colorectal carcinogenesis. The intestine must carefully balance immunity, which protects us from harmful microbes, and tolerance, which permits interactions with harmless commensal bacteria and dietary antigens. Disruptions that tilt the balance toward immune activation/inflammation could facilitate tumor progression in the intestinal tract. The loss of balance between anti-inflammatory and proinflammatory mediators may precipitate or aggravate neoplastic transformation in the intestinal epithelium. This concept is best thought of as a continuum. Illustrating the mild end of the continuum are mice held in germ-free environments, where there are fewer bacterial threats and, presumably, reduced mucosal immune activation; they do not develop intestinal tumors (21). At the severe end of the continuum, persistent inflammation in the colon is a strong independent risk factor for CRC (7). Ulcerative colitis lasting >20 years increases the risk for CRC as much as do inherited cancer syndromes such as familial adenomatous polyposis (22). The initial inflammatory insult in the gastrointestinal (GI) tract may originate from diet and carcinogenic exposures that lead to a state of low-level inflammation. Disruptions in the delicate balance between harmful microbes and harmless commensal bacteria in the GI tract that enable immune activation/inflammation could facilitate multistep tumorigenesis in the intestinal tract (Fig. 1).
Fig 1.
The balance between tolerance and activation of CRC risk. The intestine must carefully balance immunity, to protect us from harmful microbes, and tolerance, to permit interaction with harmless commensal bacteria and dietary antigens. Disruptions that tilt the balance toward immune activation/inflammation could facilitate multistage tumor progression in the intestinal tract.
Molecular Support for CHIEF, the Pathway of Convergence
The importance of the convergence of inflammation with pathways that involve hormones and energy-related factors suggests the necessity to examine the broad spectrum of these interrelated pathways rather than each pathway in isolation. This integrated approach is the essence of the CHIEF pathway (Fig. 2). The LKB1 → AMP–activated protein kinase α → tuberous sclerosis 1&2 → mammalian target of rapamycin (mTOR) → ribosomal protein S6 kinase (S6K) component of our proposed pathway senses and responds to changes in cellular ATP levels, which may be governed in part by diet, physical exercise, or inflammation (23); therefore, this component integrates nutrient and insulin signaling. Cells with low ATP and excess AMP activate LKB (STK11) at the apex of this pathway (23–26) in repressing anabolic processes (ATP use) and enhancing catabolic processes (ATP generation). The signaling pathway senses and responds to changes in cellular energy balance (ATP levels; refs. 27, 28). LKB1 is a tumor suppressor that causes Peutz-Jeghers syndrome, an autosomal dominant disorder that often manifests as hamartomatous polyps that increase the risk of intestinal cancer. LKB is an AMPK kinase and a tumor suppressor and therefore is a prominent link between metabolic signaling pathways and cell proliferation and polarity pathways (28–31). In cells with excess AMP due to altered energy homeostasis, LKB1 phosphorylates AMP-dependent kinase (PRKAA1&2; refs. 24–27), which in turn phosphorylates proximal substrates like acetyl-CoA carboxylase and tuberous sclerosis 1&2. Sequential phosphorylation of distal substrates in this kinase cascade, such as mTOR and S6K (also known as RPS6KA1&2), ultimately represses anabolic processes (ATP use) and enhances catabolic processes (ATP generation). This process restores the system to normal energy homeostasis. Overall, LKB1 is a prominent, widely expressed AMPK kinase that governs whole-body insulin sensitivity via this signaling pathway (32, 33).
Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway.
A different portion of the pathway that responds to insulin, estrogen, androgen, and certain proto-oncogene growth factors contains PTEN. PTEN is an unusual phosphatase enzyme which can preferentially remove phosphates from phosphatidyl inositol triphosphate 3, 4, and 5. Like LKB1, PTEN also has a dual role as a tumor suppressor and regulator of metabolic signaling. PTEN acts as a metabolic regulator by modulating the AKT1 kinase, which is downstream of the insulin receptor. This modulation ultimately affects the feedback inhibition processes [less insulin-receptor substrate (IRS) 1&2 transcription, more IRS1&2 phosphorylation] necessary to maintain normal insulin sensitivity. PTEN acts as a tumor suppressor by an analogous mechanism-negative regulation of the phosphatidyl inositol-3-kinase (PI3K)/AKT1 oncogenic signaling pathway. Loss of function from germ line mutations in the PTEN gene causes PTEN hamartoma tumor syndrome (34). This syndrome includes Cowden's disease, an autosomal dominant, complex disorder that manifests as malignant and benign (hamartomatous) lesions affecting breast, thyroid, uterus, brain, and mucocutaneous tissues. Because PTEN is both a tumor suppressor protein and a regulator of metabolic signaling, it is a candidate common factor in the development both of some types of cancer and insulin resistance.
Cytokines also represent the inflammatory process in the CHIEF pathway because inflammation is initiated by the synthesis and secretion of proinflammatory cytokines (e.g., TNF and IL-6 in macrophages) in response to an inflammation- provoking insult. The increased production of cytokines and subsequent elevation in reactive oxygen and nitrogen species are recognized hallmarks of inflammation. This process is regulated by a negative-feedback mechanism and closely followed by the secretion of anti-inflammatory cytokines (e.g., IL-10). As seen in Crohn's disease and ulcerative colitis, the cellular antioxidant defense system is activated to limit the development of chronic inflammation, which gives rise to a much higher-than-normal cancer risk. The binding of proinflammatory cytokines to their receptors triggers the activation of NFκB, which in turn activates the expression of a wide variety of genes including cytokines and COX-2. The unchecked activation of NFκB/COX-2 frequently occurs in colon tumor cells.
NFκB is an important nuclear transcription factor that regulates a large number of cytokines and is critical for the regulation of tumorigenesis, cell proliferation, apoptosis, response to oxidative stress, and inflammation. It plays a critical role in diseases associated with dysregulated immune response and is an important regulator of insulin; inappropriate activation of NFκB has been linked to inflammatory events. TNFα can activate the inhibitor of κB kinase (IKK) complex and induce insulin resistance (35, 36) and is thought to be one of the most important promoters of inflammation because it induces activation of at least two of the relevant major signaling pathways (IKK and NFκB). The IKK complex is the key regulator of NFκB's transcriptional activity.
NFκB regulates the IL cytokines. IL-6 stimulates liver secretion of C-reactive protein, which is now considered to be an important biomarker for proinflammatory status in several diseases including cancer (37). Serum IL-6 is increased in many inflammatory diseases, but in contrast to other cytokines such as TNF, IL-6 can have both proinflammatory and antiinflammatory effects. Serum IL-6 has been shown to be elevated in several cancers, including prostate, bladder, colon, and breast cancer (38–40). IL-8 is a proinflammatory cytokine that primarily mediates the activation and migration of neutrophils into tissue from peripheral blood. IL-10 is an immunosuppressive cytokine and also is known as the cytokine synthesis inhibitory factor. Studies have shown that IL-10 may arrest chronic inflammatory responses in atherosclerosis (41) by responding to the secretion of proinflammatory cytokines such as IL-6 and TNF and by downregulating their activity. Circulating levels of IL-10 are elevated in obese women and decreased in metabolic syndrome (42, 43).
Other cytokines with a potential impact on CRC risk through inflammation-related mechanisms include IL-1 (both IL-1α and IL-1β), IL-4, and IFN-γ. IL-1α and IL-1β are potent mediators of inflammation and immunity and have been associated with IL-6 and TNF levels in several diseases thought to have an inflammation-response element in their etiology (44, 45). IL-1β is an important element in the angiogenesis and invasiveness of several tumor cells (18). IL-1 receptor A is responsible for regulating IL-1α and IL-1β. IL-4 protects endothelial cells from the cytotoxic effects of the PI3K/Akt signaling pathway (46) and inhibits NFκB and calcium signaling (47, 48). IL-4 may have a direct effect on intestinal epithelial cells and upregulates the expression of suppressors of cytokine signaling (49, 50). INF-γ is a proinflammatory cytokine that can activate the transcription factors NFκB and c-Jun N terminal kinase (JNK).
Steroid hormones including estrogen, androgen, and progesterone have been shown to have both anti-inflammatory and proinflammatory properties (51, 52) and, therefore, are components of an inflammation-related pathway. The receptors of the steroid hormones have been shown to interact with NFκB in an antagonist manner (52–54). However, studies also suggest that the influence of estrogen may depend on cell type and form of estrogen (51, 52, 55). Estrogen receptor (ER) β, the most abundant ER in the GI tract, has been shown to have a dramatically beneficial effect in the HLA-B27 transgenic rat model of inflammatory bowel disease (56). Estrogen also has been shown to repress IL-6 expression as well as IκB, potentially explaining its anti-inflammatory mechanism (52, 57). It has been hypothesized that ER-negative breast tumors may metastasize through activation of NFκB and IκB due to loss of ER function (52).
It is hypothesized that inflammation-related mechanisms are associated with insulin through the axis connecting IRS1&2 → PI3K → AKT1 → tuberous sclerosis 1&2 → mTOR→ S6K1&2. The VEGF gene may influence CRC development through its action on tumor cells and angiogenesis; VEGF also regulates S6K and IRS-1 and may play an important role in regulating cell growth signaling within this pathway (58). PTEN restrains insulin signaling via this pathway. Chemical inactivation of PTEN also predisposes to polyp formation and the attendant risk for cancer.
Signal transduction and activation of transcription (STAT) and mitogen-activated kinases (MAPK) are involved in both inflammation and metabolic signaling associated with hormones and energy-related factors. STAT protein family members are phosphorylated in response to cytokines and growth factors. Therefore, their involvement in convergent areas of multiple pathways makes them attractive candidate etiologic factors of CRC. STAT-1 is activated by NFκB, IFN-γ, IL-1, and IL-6 and mediates the expression of a variety of genes; STAT-1–dependent transcription of proinflammatory genes is regulated by IFN-γ–activated PI3K and mTOR pathways (59). Data also suggest that STAT-1 activation can contribute to maintaining and expanding the local inflammatory response in celiac disease and may therefore have implications for CRC (60). STAT-6 plays a central role in IL-4–mediated biological responses that involve TNFα, IL-8, and NFκB, and the STAT-6 pathway contributes to the hypercontractility of intestinal muscle in Crohn's disease (61). STAT-6 also is involved in signaling from the leptin receptor and may therefore be involved in obesity and energy balance (62).
MAPKs are a family of STKs that serve as an integration point for multiple biological signals and are involved in a variety of cellular processes such as proliferation, differentiation, and transcription regulation. JNK-1 or MAPK-8 is activated by TNFα and is necessary for apoptosis. NFκB is required to terminate JNK signaling. JNK-1 activity is elevated in obesity, and an absence of JNK-1 results in decreased adiposity and improved insulin sensitivity (63). P38MAPK (also known as MAPK-14) is activated by environmental stresses and proinflammatory cytokines. TP53 is mutated in roughly half of CRCs and is one of the substrates of P38MAPK, suggesting a role in cell cycle regulation. P38MAPK plays a role in multiple pathways that include the release of VEGF and is involved in the PI3K pathway related to IL6 gene expression.
Epidemiologic Support for the CHIEF Pathway
Given the physiologic properties of the gut, the molecular properties of the CHIEF pathway, and the relevant epidemiology literature, it is reasonable to hypothesize that inflammation is the underlying determinant of CRC risk because it mediates the risk associated with many other factors. There is intriguing epidemiologic evidence of inflammatory mediators interacting with various metabolic, hormonal, and energy-related factors to alter the risk of CRC, suggesting that they may be central to explaining observed inconsistencies in the literature surrounding CRC risk factors. As previously noted, several inflammatory conditions predispose to CRC.
Epidemiologic and clinical data consistently support an association between aspirin and other nonsteroidal anti-inflammatory drugs (NSAID) and a reduced risk of CRC (64), suggesting that inflammation-lowering factors reduce CRC risk. NSAIDs also have been shown to modulate CRC risk associated with diet, life-style, and genetic factors (65). In laboratory settings, high doses of salicylates (salts and esters of salicylic acid, which is similar but not identical to the active ingredient of aspirin) inhibit NFκB and its upstream activator IKKβ, which regulate immune cell differentiation and survival (36). A 2- to 3-fold increased risk of colon cancer has been associated in some studies with high levels of C-reactive protein, a marker of systemic inflammation (37).
Although limited, epidemiologic studies of polymorphisms of genes thought to be involved in inflammation-related pathways provide additional support for inflammatory processes as a component of CRC development. Polymorphisms in IL8 have been associated with inflammation levels and CRC development (66). In a study using hospital-based controls (66), associations between CRC risk and inflammation-related polymorphisms included a 50% reduction associated with the Ala variant of P12A peroxisome proliferator-activated receptor γ (PPAR-γ), a 70% increase associated with the C allele for IL6, and a 30% reduction in risk associated with the A allele of IL8. Another population-based study of CRC showed that ibuprofen-type drugs significantly interacted with the P12A PPAR-γ polymorphism to alter rectal cancer risk (67). SMAD7 single nucleotide polymorphisms have been shown to be associated with colon cancer risk in genome-wide association studies (68, 69); SMAD7 is involved in inflammation-related pathways and has been shown to modulate transforming growth factor β and wnt signaling (70). Confirmatory studies of the SMAD7 association with colon cancer showed that aspirin and/or NSAID use modified the CRC risk associated with SMAD7.5 Polymorphisms of IFN-γ have been shown to influence survival in patients with pancreatic cancer and breast cancer (71) and may be an important mediator of inflammation-related processes. Most inflammation-related genes, however, have not been examined for potential associations with CRC.
Androgenic and estrogenic steroids and insulin-related hormones have been identified as key risk factors in the etiology of CRC. Women taking hormone replacement therapy have been shown to have a reduced CRC risk in both observational studies and clinical trials (72, 73); it seems that aspirin may modulate the risk associated with estrogen (74). Genetic polymorphisms in both the androgen receptor and ER genes are associated with altered CRC risk (75). Estrogen represses the production of IL-6 through an ER-dependent mechanism; serum levels of IL-6 increase following menopause in healthy women and with age in both men and women (76, 77).
An insulin-related pathway has been proposed as a unifying mechanism underlying several CRC risk factors including physical inactivity, obesity, and certain dietary factors such as glycemic index and dietary fiber (78, 79). Polymorphisms of genes associated with insulin-related pathways, such as IRS1, are associated with colon cancer, and these associations can be modified by aspirin use (80). Insulin-like growth factor (IGF) 1 (IGF1), IGF binding protein 3 (IGFBP3), IRS2, and IGF receptor 1 (IGFR1) polymorphisms have not been consistently associated with CRC risk. Polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been associated with insulin sensitivity and diabetes, and TCF7L2 is involved in the Wnt/β-catenin signaling pathway, all thought to be important factors in the etiology of colon cancer (81, 82). Folsom et al. (83) showed a significantly increased CRC risk in association with the T allele of the rs7903146 TCF7L2 polymorphism. A significant interaction has been found between the rs7903146 TCF7L2 polymorphism and recent use of aspirin/NSAIDs (Pinteraction = 0.001); an increased colon cancer risk associated with the T allele was restricted to people who had not recently used aspirin and/or NSAIDs [odds ratio, 1.65; 95% CI, 1.35-2.02) relative to recent (within 2 years before diagnosis) aspirin and/or NSAID users with the CC genotype; ref. 84]; and recent aspirin and/or NSAIDs use reduced colon cancer risk in people with the T allele (odds ratio, 0.78; 95% CI, 0.62-0.98) in a dose-response fashion (P = 0.03 for a linear trend across genotypes; ref. 84). These data provide additional support for aspirin and/or NSAIDs use, a crude potential surrogate for the inflammatory state of the GI tract, as an important mediator of hormone-related CRC risk.
The associations between insulin-related factors, including polymorphisms of genes in an insulin-related pathway, and CRC seem to be modified by aspirin use (80). Furthermore, salicylates have been shown to have a hypoglycemic effect (85–89), and high doses of salicylates can reverse hyperglycemia, hyperinsulinemia, and dyslipidemia by influencing insulin signaling (36). Epidemiologic studies show strong associations between systemic markers of inflammation (e.g., IL-6, TNF) and a heightened risk for obesity-related insulin resistance (90–93). Laboratory studies support a role for the inflammatory cytokine TNF and the NFκB signaling pathway in the association between obesity, chronic inflammation, and insulin resistance (94, 95). TNF has been reported to inhibit insulin-induced glucose uptake by targeting components of the insulin-signaling cascade, one component of which is IRS-1 (96–100). Aspirin has been shown to protect insulin-induced glucose uptake in TNF-treated adipocytes by blocking TNF effects on IRS1 (96).
Although steroid- and insulin-related hormonal factors seem to be important in CRC etiology, it also seems that they do not reflect isolated pathways to cancer development; rather, they reflect an interrelated hormone-related pathway that operates on an underlying state of inflammation. Given the recurring theme of effect modification by aspirin and/or NSAIDs, it seems that the inflammatory state of the GI tract may be an important determinant of the CRC risk associated with estrogen and androgen and insulin-related factors.
Energy-related factors include factors related to energy balance, diet, physical activity, and obesity. These factors also have been proposed as key factors related to insulin signaling (79). Epidemiologic data show inconsistent associations between energy intake and CRC risk, and between energy-contributing nutrients (such as dietary fat) and CRC risk (101). Although physical activity has been consistently associated with a reduced risk of colon cancer, its association with rectal cancer risk has been inconsistent (102). Overweight and obesity have been identified consistently as important risk factors for colon cancer among men, premenopausal women, and postmenopausal women taking hormone replacement therapy (103–106); data suggest that body mass index (BMI)–related colon cancer risk also is modulated by aspirin and/or NSAIDs (107).
Diet, physical inactivity, and obesity are associated with inflammation as well as with insulin signaling. The finding that high-fat meals increase the coabsorption of enteric bacterial lipopolysaccaride endotoxin, causing low-grade endotoxemia and postprandial inflammation (108), links diet to an inflammation pathway. Studies suggest that aspirin use may modify harmful effects of dietary fat, and it has been suggested that a lower CRC risk associated with dietary fat in more recent years may relate to higher aspirin use in the general population (109, 110), suggesting further that dietary fat effects on CRC risk may involve an inflammation-related mechanism. IL-6 is a “mytokine,” or a cytokine produced in muscle, and is elevated in response to muscle contraction (111). It is significantly elevated with exercise and proceeds the appearance of other cytokines in the circulation. During exercise, IL-6 is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery (111). Therefore, inflammation-related mediators also may influence the effects of physical inactivity, a factor consistently associated with colon cancer risk.
Data on associations between body size and TNFα, IL-6, leptin, and adiponectin support obesity as an “inflammatory state.” Adipose tissue expresses mRNA for TNFα, and this expression is increased in healthy obese adults (112, 113). IL-6 is produced by the stroma of adipose tissue, and serum IL-6 levels are increased in healthy obese individuals, independently of age or menopause (112). It is estimated that about one third of circulating IL-6 in a healthy individual derives from adipose tissue (114). Qi et al. (115) studied associations between the genetic variability of IL6 and long-term changes in or related to BMI among 2,255 healthy women and 980 healthy men from two prospective cohorts. The IL6 haplotype 222211 (comprising rs2069827, rs1800797, rs1800795, rs1554606, rs2069861, and rs1818879; 1 codes the common allele and 2 codes the minor allele) was consistently and significantly associated with a greater waist circumference (P = 0.009 in men and 0.0003 in women) and baseline BMI (P = 0.01 in men and 0.046 in women) compared with the most common IL6 haplotype, 111112. A 5-prime polymorphism, rs2069827, also was consistently associated with significantly higher early-adulthood BMI, baseline BMI, and waist circumference in men and women. Adipose tissue secretes adipokines such as adiponectin and leptin. As members of the IL-6 family of cytokines, leptin and its receptor are considered to be proinflammatory cytokines and to play a major role in modulating inflammation and immune response (116, 117). Epidemiologic data have shown a statistically significant interaction between recent use of aspirin and/or NSAIDs and leptin (LEP) polymorphisms and the risk of developing colon cancer (118).
The physiologic structure of the gut and supportive epidemiologic and molecular data led us to propose that basal immune activation—a repetitive, mild subclinical inflammation—is the underlying modulator of CRC risk and influences the CRC risk associated with insulin, estrogen, and energy-related factors. The CHIEF pathway integrates elements of angiogenesis, hormones, and energy-related factors with the underlying inflammatory state of the colon and rectum. Additional support for the importance of the CHIEF pathway comes from the fact that many of its genes are tumor suppressor genes, which frequently are mutated in CRC.
We believe that the CHIEF pathway of convergence resonates with other cancers including breast and possibly prostate cancer. Breast and prostate cancer risk assessments have revealed many of the same risk factors, with varying levels of risk and relative importance, as those identified for CRC. It is intriguing that obesity seems to increase colon cancer risk (119) and is associated with a reduced breast cancer risk (120) in premenopausal women. Hormone replacement therapy reduces the risk of colon cancer, whereas it increases the risk of breast cancer (73). Aspirin and NSAIDs reduce the risk of colon cancer, whereas their association with breast cancer risk is inconsistent (121–123). Inflammation-related factors may be pivotal for colon cancer risk, but the pivotal component of the pathway for breast cancer may be estrogen because the epidemiologic data suggest that menopausal status and estrogen are central effect modifiers of other risk factors. The pivotal pathway component is most likely determined by the underlying tissue structure. For CRC, we believe that the primary determinant of risk is inflammation. Given the close relationship of the key pathway elements, however, the ultimate pathway to carcinogenesis involves all of the elements of CHIEF.
Randomized clinical trials have reinforced the conclusions from over 40 observational studies that NSAIDs, which inhibit the COX enzymes, prevent colorectal adenomas as well as CRC (124, 125). An understanding of key elements in the CHIEF pathway and their role in the carcinogenic process promises to lead to practical approaches for both prevention and treatment.
Grant support: Grant CA48998 (M.L. Slattery) from the National Cancer Institute, NIH.
↵5M.L. Slattery, J. Herrick, K. Curtin, et al. unpublished data.
Received October 16, 2008.
Revision received April 3, 2009.
Accepted April 29, 2009.
Lippman SM,
Hawk ET
. Cancer prevention: from 1727 to milestones of the past 100 years. Cancer Res 2009;69:5269–84.
Abreu-Martin MT,
Targan SR
. Regulation of immune responses of the intestinal mucosa. Crit Rev Immunol 1996;16:277–309.
Rothenberg ME,
Mishra A,
Brandt EB,
Hogan SP
. Gastrointestinal eosinophils. Immunol Rev 2001;179:139–55.
Hunyady B,
Mezey E,
Palkovits M
. Gastrointestinal immunology: cell types in the lamina propria-a morphological review. Acta Physiol Hung 2000;87:305–28.
Corr SC,
Gahan CC,
Hill C
. M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. FEMS Immunol Med Microbiol 2008;52:2–12.
Soler AP,
Miller RD,
Laughlin KV,
Carp NZ,
Klurfeld DM,
Mullin JM
. Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis 1999;20:1425–31.
Itzkowitz SH,
Yio X
. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004;287:G7–17.
Fitzpatrick FA
. Inflammation, carcinogenesis and cancer. Int Immunopharmacol 2001;1:1651–67.
Coussens LM,
Werb Z
. Inflammation and cancer. Nature 2002;420:860–7.
Clevers H
. At the crossroads of inflammation and cancer. Cell 2004;118:671–4.
Kato M,
Kephart GM,
Morikawa A,
. Eosinophil infiltration and degranulation in normal human tissues: evidence for eosinophil degranulation in normal gastrointestinal tract. Int Arch Allergy Immunol 2001;125 Suppl 1:55–8.
Moezzi J,
Gopalswamy N,
Haas RJ Jr.,
Markert RJ,
Suryaprasad S,
Bhutani MS
. Stromal eosinophilia in colonic epithelial neoplasms. Am J Gastroenterol 2000;95:520–3.
Lotfi R,
Lee JJ,
Lotze MT
. Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors. J Immunother 2007;30:16–28.
Ono M
. Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci 2008;99:1501–6.
Lohela M,
Bry M,
Tammela T,
Alitalo K
. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 2009.
Carmeliet P,
Jain RK
. Angiogenesis in cancer and other diseases. Nature 2000;407:249–57.
Saijo Y,
Tanaka M,
Miki M,
. Proinflammatory cytokine IL-1 β promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction. J Immunol 2002;169:469–75.
Voronov E,
Shouval DS,
Krelin Y,
. IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A 2003;100:2645–50.
Kuwano T,
Nakao S,
Yamamoto H,
. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J 2004;18:300–10.
Harris RE
. Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer. Subcell Biochem 2007;42:93–126.
Sinicrope FA
. Sporadic colorectal cancer: an infectious disease? Gastroenterology 2007;132:797–801.
Lashner BA
. Colorectal cancer in ulcerative colitis patients: survival curves and surveillance. Cleve Clin J Med 1994;61:272–5.
Lizcano JM,
Goransson O,
Toth R,
. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 2004;23:833–43.
Woods A,
Johnstone SR,
Dickerson K,
. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003;13:2004–8.
Hawley SA,
Boudeau J,
Reid JL,
. Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003;2:28.
Shaw RJ,
Kosmatka M,
Bardeesy N,
. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 2004;101:3329–35.
Carling D
. Ampk. Curr Biol 2004;14:R220.
Hardie DG
. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003;144:5179–83.
Kyriakis JM
. At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation. J Biol 2003;2:26.
Baas AF,
Kuipers J,
van der Wel NN,
. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 2004;116:457–66.
Corradetti MN,
Inoki K,
DePinho RA,
Guan KL
. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004;18:1533–8.
. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem Sci 2004;29:18–24.
Viollet B,
Andreelli F,
Jorgensen SB,
. Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem Soc Trans 2003;31:216–9.
Pilarski R,
Eng C
. Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome. J Med Genet 2004;41:323–6.
White MF
. Insulin signaling in health and disease. Science 2003;302:1710–1.
Yuan M,
Konstantopoulos N,
. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 2001;293:1673–7.
Erlinger TP,
Platz EA,
Rifai N,
Helzlsouer KJ
. C-reactive protein and the risk of incident colorectal cancer. JAMA 2004;291:585–90.
Bozcuk H,
Uslu G,
Samur M,
. Tumour necrosis factor-α, interleukin-6, and fasting serum insulin correlate with clinical outcome in metastatic breast cancer patients treated with chemotherapy. Cytokine 2004;27:58–65.
Mantovani G,
Maccio A,
Madeddu C,
. Quantitative evaluation of oxidative stress, chronic inflammatory indices and leptin in cancer patients: correlation with stage and performance status. Int J Cancer 2002;98:84–91.
Salgado R,
Junius S,
Benoy I,
. Circulating interleukin-6 predicts survival in patients with metastatic breast cancer. Int J Cancer 2003;103:642–6.
Terkeltaub RA
. IL-10: an “immunologic scalpel” for atherosclerosis? Arterioscler Thromb Vasc Biol 1999;19:2823–5.
Esposito K,
Marfella R,
Giugliano D
. Stress hyperglycemia, inflammation, and cardiovascular events. Diabetes Care 2003;26:1650–1.
Nappo F,
Giugliano F,
. Cytokine milieu tends toward inflammation in type 2 diabetes. Diabetes Care 2003;26:1647.
Watanabe E,
Hirasawa H,
Oda S,
Matsuda K,
Hatano M,
Tokuhisa T
. Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms. Crit Care Med 2005;33:89–97; discussion 242–3.
Kasahara T,
Yagisawa H,
Yamashita K,
Yamaguchi Y,
Akiyama Y
. IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: positive and negative modulation by chorela toxin and cAMP. Biochem Biophys Res Commun 1990;167:1242–8.
Grehan JF,
Levay-Young BK,
Fogelson JL,
Francois-Bongarcon V,
Benson BA,
Dalmasso AP
. IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/akt pathway. J Immunol 2005;175:1903–10.
Mangashetti LS,
Khapli SM,
Wani MR
. IL-4 inhibits bone-resorbing activity of mature osteoclasts by affecting NF-{κ}B and Ca2+ signaling. J Immunol 2005;175:917–25.
Yamamoto T,
Imoto S,
Sekine Y,
. Involvement of NF-[κ]B in TGF-[β]-mediated suppression of IL-4 signaling. Biochem Biophys Res Commun 2004;313:627–34.
Hebenstreit D,
Luft P,
Schmiedlechner A,
. J Immunol 2003;171:5901–7.
Blanchard C,
Durual S,
Estienne M,
. IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis. J Immunol 2004;172:3775–83.
Nilsson BO
. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm Res 2007;56:269–73.
McKay LI,
Cidlowski JA
. Molecular control of immune/inflammatory responses: interactions between nuclear factor-κB and steroid receptor-signaling pathways. Endocr Rev 1999;20:435–59.
De Bosscher K,
Vanden Berghe W,
Haegeman G
. Cross-talk between nuclear receptors and nuclear factor κB. Oncogene 2006;25:6868–86.
Chadwick CC,
Chippari S,
Matelan E,
. Identification of pathway-selective estrogen receptor ligands that inhibit NF-κB transcriptional activity. Proc Natl Acad Sci U S A 2005;102:2543–8.
Cerillo G,
Rees A,
Manchanda N,
. The oestrogen receptor regulates NFκB and AP-1 activity in a cell-specific manner. J Steroid Biochem Mol Biol 1998;67:79–88.
Harris HA,
Albert LM,
Leathurby Y,
. Evaluation of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 2003;144:4241–9.
Ray P,
Ghosh SK,
Zhang DH,
Ray A
. Repression of interleukin-6 gene expression by 17 β-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-κB by the estrogen receptor. FEBS Lett 1997;409:79–85.
Watson CJ,
Webb NJ,
Bottomley MJ,
Brenchley PE
. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine 2000;12:1232–5.
Kristof AS,
Marks-Konczalik J,
Billings E,
Moss J
. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-{γ} is regulated by mammalian target of rapamycin 10.1074/jbc M301053200. J Biol Chem 2003;278:33637–44.
Mazzarella G,
MacDonald TT,
Salvati VM,
. Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions. Am J Pathol 2003;162:1845–55.
Klein W,
Tromm A,
Folwaczny C,
. The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease. Dig Liver Dis 2005;37:159–161.
Ghilardi N,
Ziegler S,
Wiestner A,
Stoffel R,
Heim MH,
Skoda RC
. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A 1996;93:6231–5.
Onuma M,
Bub JD,
Rummel TL,
Iwamoto Y
. Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase 10.1074/jbc M304984200. J Biol Chem 2003;278:42660–7.
Collet JP,
Sharpe C,
Belzile E,
Boivin JF,
Hanley J,
Abenhaim L
. Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing. Br J Cancer 1999;81:62–8.
Camp NJ,
Slattery ML
. Classification tree analysis: a statistical tool to investigate risk factor interactions with an example for colon cancer (United States). Cancer Causes Control 2002;13:813–23.
Landi S,
Moreno V,
Gioia-Patricola L,
. Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor α, NFKB1, and peroxisome proliferator-activated receptor γ with colorectal cancer. Cancer Res 2003;63:3560–6.
Slattery ML,
Murtaugh MA,
Sweeney C,
. PPARγ, energy balance, and associations with colon and rectal cancer. Nutr Cancer 2005;51:155–61.
Broderick P,
Carvajal-Carmona L,
Pittman AM,
. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet 2007;39:1315–7.
Tenesa A,
Farrington SM,
Prendergast JG,
. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 2008.
ten Dijke P,
Hill CS
. New insights into TGF-β-Smad signalling. Trends Biochem Sci 2004;29:265–73.
Wu JM,
Bensen-Kennedy D,
Miura Y,
. The effects of interleukin 10 and interferon γ cytokine gene polymorphisms on survival after autologous bone marrow transplantation for patients with breast cancer. Biol Blood Marrow Transplant 2005;11:455–64.
Nanda K,
Bastian LA,
Hasselblad V,
Simel DL
. Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis. Obstet Gynecol 1999;93:880–8.
Nelson HD,
Humphrey LL,
Nygren P,
Teutsch SM,
Allan JD
. Postmenopausal hormone replacement therapy: scientific review. JAMA 2002;288:872–81.
Quesenberry C,
Caan BJ,
Edwards S,
Sweeney C
. Changing population characteristics, effect-measure modification, and cancer risk factor identification. Epidemiol Perspect Innov 2007;4:10.
Murtaugh M,
. Associations between ERα, ERβ, and AR genotypes and colon and rectal cancer. Cancer Epidemiol Biomarkers Prev 2005;14:2936–42.
Jiang XP,
Yang DC,
Elliott RL,
Head JF
. Reduction in serum IL-6 after vacination of breast cancer patients with tumour-associated antigens is related to estrogen receptor status. Cytokine 2000;12:458–65.
Morley JE,
Baumgartner RN
. Cytokine-related aging process. J Gerontol A Biol Sci Med Sci 2004;59:M924–9.
Giovannucci E
. Insulin and colon cancer. Cancer Causes Control 1995;6:164–79.
Kaaks R
. Nutrition, energy balance and colon cancer risk: the role of insulin and insulin-like growth factor-I. IARC Sci Publ 2002;156:289–93.
Samowitz W,
Hoffman M,
Ma KN,
Levin TR,
Neuhausen S
. Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. Cancer Epidemiol Biomarkers Prev 2004;13:538–45.
Lyssenko V,
Lupi R,
Marchetti P,
. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007;117:2155–63.
Kuusisto J,
Vanttinen M,
. Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 2007;50:1192–200.
Folsom AR,
Pankow JS,
Peacock JM,
Bielinski SJ,
Heiss G,
Boerwinkle E
. Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care 2008;31:905–9.
Wolff R,
Herrick J,
Potter JD
. Transcription factor 7-like 2 polymorphism and colon cancer. Cancer Epidemiol Biomarkers Prev 2008;17:978–82.
Fang V,
Foye WO,
Robinson SM,
Jenkins HJ
. Hypoglycemic activity and chemical structure of the salicylates. J Pharm Sci 1968;57:2111–6.
Graef I,
Gibbons DM
. Salicylates and carbohydrate metabolism. Diabetes 1960;9:416–8.
Powell ED,
Field RA
. Studies on salicylates and complement in diabetes. Diabetes 1966;15:730–3.
McRae JR,
Chen M,
Robertson RP
. Improvement of defective insulin responses to glucose, arginine, and β-adrenergic stimulation in diabetics by sodium salicylate. Adv Prostaglandin Thromboxane Res 1980;8:1287–9.
Baron SH
. Salicylates as hypoglycemic agents. Diabetes Care 1982;5:64–71.
Festa A,
D'Agostino R Jr..,
Howard G,
Mykkanen L,
Tracy RP,
Haffner SM
. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000;102:42–7.
Schmidt MI,
Duncan BB,
Sharrett AR,
. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999;353:1649–52.
Pradhan AD,
Cook NR,
Buring JE,
Manson JE,
Ridker PM
. C-reactive protein is independently associated with fasting insulin in nondiabetic women. Arterioscler Thromb Vasc Biol 2003;23:650–5.
Kubaszek A,
Pihlajamaki J,
Komarovski V,
. Promoter polymorphisms of the TNF-α (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes 2003;52:1872–6.
Barnes GT,
Yang Q,
. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821–30.
Hirosumi J,
Tuncman G,
Chang L,
. A central role for JNK in obesity and insulin resistance. Nature 2002;420:333–6.
Gao Z,
Zuberi A,
Quon MJ,
Dong Z,
Ye J
. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem 2003;278:24944–50.
Hotamisligil GS
. Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation. FEBS Lett 2001;506:97–102.
. The role of TNFα and TNF receptors in obesity and insulin resistance. J Intern Med 1999;245:621–5.
Hotamisligil GS,
Peraldi P,
Budavari A,
Ellis R,
White MF,
Spiegelman BM
. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science 1996;271:665–8.
Hofmann C,
Lorenz K,
Braithwaite SS,
. Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 1994;134:264–70.
. Diet, body weight, and colorectal cancer: a summary of the epidemiologic evidence. J Womens Health (Larchmt) 2003;12:173–82.
. Physical activity and colorectal cancer. Sports Med 2004;34:239–52.
Coates AO,
Potter JD,
Quesenberry CP Jr..,
Edwards SM
. Body size and the risk of colon cancer in a large case-control study. Int J Obes Relat Metab Disord 1998;22:178–84.
Le Marchand L,
Wilkens LR,
Kolonel LN,
Hankin JH,
Lyu LC
. Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Res 1997;57:4787–94.
Mi MP
. Obesity in youth and middle age and risk of colorectal cancer in men. Cancer Causes Control 1992;3:349–54.
Giovannucci E,
Ascherio A,
Rimm EB,
Colditz GA,
Stampfer MJ,
Willett WC
. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 1995;122:327–34.
Swenney C
. Changing population characteristics, effect modification, and cancer risk factor identification. Epidemiol Perspect Innov 2007;4:10.
Erridge C,
Attina T,
Spickett CM,
Webb DJ
. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 2007;86:1286–92.
Benson J,
Schaffer D,
. Trans-fatty acids and colon cancer. Nutr Cancer 2001;39:170–5.
Hartman TJ,
Yu B,
Albert PS,
. Does nonsteroidal anti-inflammatory drug use modify the effect of a low-fat, high-fiber diet on recurrence of colorectal adenomas? Cancer Epidemiol Biomarkers Prev 2005;14:2359–65.
Pedersen BK
. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem 2006;42:105–17.
Arner P,
Caro JF,
Atkinson RL,
. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 1995;95:2409–15.
Kern PA,
Saghizadeh M,
Ong JM,
Bosch RJ,
Deem R,
Simsolo RB
. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995;95:2111–9.
Mohamed-Ali V,
Goodrick S,
Rawesh A,
. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab 1997;82:4196–200.
Qi L,
van Dam RM,
Meigs JB,
Hunter D,
Hu FB
. Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis. Hum Mol Genet 2006;15:1914–20.
Otero M,
Lago R,
Lago F,
. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 2005;579:295–301.
Loffreda S,
Yang SQ,
Lin HZ,
. Leptin regulates proinflammatory immune responses. FASEB J 1998;12:57–65.
Wolff RK,
. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. Int J Cancer 2008;122:1611–7.
Ballard-Barbash R,
. Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States). Cancer Causes Control 2003;14:75–84.
. Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women. Breast Cancer Res Treat 2006.
Sandler RS
. Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer. Important Adv Oncol 1996:123–37.
Egan KM,
Rosner BA,
Colditz GA
. Prospective study of regular aspirin use and the risk of breast cancer. J Natl Cancer Inst 1996;88:988–93.
Slattery M,
Curtin K,
Baumgartner R,
. IL6, aspirin, non-steroidal anti-inflammatory drugs, and breast cancer risk in women living in the Southwestern United States. Cancer Epidemiol Biomarkers Prev 2007;16:1–9.
Bertagnolli MM,
Eagle CJ,
Zauber AG,
. Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med 2006;355:873–84.
Arber N,
Spicak J,
. Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med 2006;355:885–95.
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Ally’s Kitchen Shares Inspiring Story, Holiday Dishes and Family!
Inspiring cook, Masterchef Contestant and GE’s Great American Grandma Ally Phillips of Ally’s Kitchen joined journalist and blogger, Candace Rose Anderson of the blog Candie Anderson (candieanderson..com) to share her inspiring story, her favorite holiday dishes, family, amazing air fried food, and more. Image courtesy of Ally Phillips
One of the perks of my job is getting to interview inspiring people! Ally Phillips of Ally’s Kitchen is one of my favorite people I have interviewed in over 10 years. We just met last week and I feel as though I have known her for years. She is a former psychologist who decided in her 60s that it was time for a career change. Ally is an amazing cook and was a contestant on MasterChef! She was a finalist on Hallmark “Home & Family”, is a cookbook author, and that’s just the beginning! Did I mention that her Instagram account is phenomenal? There’s so much to learn from Ally’s Kitchen! One of her most recent accolades is being named GE Appliances Great American Grandma.
Ally was kind enough to join me for an interview recently to talk family, her family’s favorite recipes, holiday feasts, and my favorite of all – how to eat greasy foods while cutting calories. She also dished on how to use the GE Profile Wall Oven which has a built-in air fry mode. As someone who owns an air fryer, I must say this is a fabulous addition!
Please be sure to watch the interview below to hear the inspiring Ally Phillips of Ally’s Kitchen dish on everything from inspiring the kids in her family to cook and try new food to how to eat greasy food without the calories, her family’s holiday traditions and her inspiring story! She is definitely one to follow. Happy Holidays!
Watch Candie Anderson interview Masterchef contestant and GE’s Great American Grandma, Ally Phillips
How To Inspire Kids To Cook And Try New Foods
Candie Anderson: You’re such an amazing cook, your family is so fortunate to have you. What are some of their favorites?
Ally Phillips: “We span six generations in our family, Candace. The youngest is 13 months old. What everybody likes is my award winning bolognese meatballs and pasta. I just make extra meatballs for the little ones. They’re not quite into red chili flakes and all the spices.
Another thing I love to do, Candace is just involve the little ones in the kitchen because if they’re cooking with me, they’re more likely to eat it. I have all these little step stools and they’ve all got their own spoons. I like to give things quirky names. I’m almost like an entertainer in the kitchen with them. We might be doing a soup and I’ll say ‘this is the witch’s brew soup’ or a grilled cheese sandwich becomes ‘a stegosaurus cheese’ because we can put bones in it or have no bones – which are basically grapes skewered on a toothpick.
All of these things make it so much fun when the kids sit down and they’re eating that soup – gobbling down those peas and carrots and onions and they don’t even know because they think they’re eating witch’s brew soup.”
How To Cut Calories When Preparing Greasy Food
Candie Anderson: As a huge fan of greasy food, do you have any tips on how to enjoy favorite greasy foods while keeping the calories down and the clutter off our counters?
Ally Phillips: “Who doesn’t like crispy crunchy fried food? I’ve lived in the south for decades. I love fried pickles, fried chicken, onion rings and all of these things. Up until now, it was just on special occasions. With GE Appliances, GE Profile Wall Oven’s new technology there is an air fry built-in mode. It’s precision cooking, which means there is perfect results every time. You have the crisp crunch, and you don’t have the kitchen appliance that just clutters your kitchen counter.”
For more on the GE Profile Wall Oven and to see Ally demonstrate how to cook chicken wings, please watch the video above.
Ally Phillips of Ally’s Kitchen shares her favorite holiday dishes just in time for Thanksgiving! Image courtesy of Unsplash Photo by Priscilla Du Preez
Ally’s Favorite Holiday Dishes
Candie Anderson: With the holidays quickly approaching, what are some of your favorite foods to prepare?
Ally Phillips: “On the holidays I like to prepare traditional recipes. We’ve got dressing mounds that have been in our family for 60/70 years. They’re delicious with a giblet and a liver gravy. I also like to have new things that we introduce to the table. We may have roasted Brussels sprouts with a ruby red honey soy sauce over it and some slivered almonds.
I like to do a couple of really traditional high calorie (the gravy, the dressing) and then err on the side of lots of healthy platters that are roasted vegetables and are easy on the waistline.”
Ally Shares Her Inspiring Story
Candie Anderson: Can you tell us what it was like being crowned the GE Appliance Great American Grandma?
Ally Phillips: “Never in my wildest dreams, Candace did I think that I would receive a crown at the age of 70. My mantra in life is that dreams have no expiration date. We’re not like food, we don’t expire. You never stop dreaming, even in your 60s, 70s, 80s and 90s. In my early 60s I decided to reinvent myself. I had been a psychologist (I was Dr. Alice for over 30 years) in private practice. I just wanted to follow my passion of cooking. My sons would say ‘Mom what are you doing this for? What’s your mission plan? What’s your business plan?’ I said I just like cooking and I’ve got social media now. I can share it, people like it and I make them happy, smile and it’s good food.
I started entering cooking contests and doing other things, Candace. It just started kind of to percolate and exploding. This opportunity for GE Appliances Great American Grandma came across my screen and I thought I could do that. They had the job descriptions: love to take selfies, social media, love to cook.
I’m a gun slinger in the kitchen. I can come in and open your refrigerator and cook a meal, and you think you have nothing.
I did the video resume, hundreds were sent in – amazing grandmas. I was lucky enough to be chosen as the great American grandma. I’m loving every minute of it.”
Where To Go For More Information
Candie Anderson: Do you have any additional tips or information you’d like to share with us?
Ally Phillips: “If you want more information on this new smart technology, recipes go to GEAppliances.com or AllysKitchen.com – that’s my website. You’ll see everything! They’re cross connected. You’ll see all the adventures. You’ll see my family. You’ll see everything I cook. You’ll know my life. We love gathering you around the table and you become our family. There’s always a seat at the table for you, Candace.”
Ally Phillips of Ally’s Kitchen Bio
Ally Phillips: When a move in 2008 to Boston brought a new job for husband, Ben, Ally, formerly Dr. Alice a School Psychologist for 35 years, decided to ‘reinvent’ herself. She wanted to live her passions for acting, stage work and cooking. Her big break in cooking came with an audition for Season 1 of MasterChef. She made it to the semifinals, but was not cast. Not to be deterred, she re-auditioned for Season 2 and was selected as a contestant. Since then Ally’s won numerous cooking contests, from the Wisconsin Cheese Grilled Cheese Academy competition and many more to the coveted Dole California CookOff. She’s been a Top 10 Finalist at the World Food Championships, competed on Food Network’s ‘Clash of the Grandmas’ and was selected as a finalist on Hallmark Channel’s Home & Family ‘Best Home Cook’. In 2015 she authored her first cookbook, “Ally’s Kitchen: A Passport for Adventurous Palates’. Ally manages a huge chunk of her own website, allyskitchen.com, where her original recipes and lifestyle adventures are chronicled. She calls herself the ‘Goddess of Everything’ in Ally’s Kitchen where she designs all of own food styling, tablescapes and shoots most all of her food/lifestyle photography. Ally’s well connected on social media with a robust following of foodie fans numbering close to three-quarters of a million followers on the various platforms. Phillips is an avid traveler and brings back flavors and recipe ideas from around the globe, believing that the common DNA of all people and cultures is food.
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NO COLOR SONG!
Thread starter matti
I find this odd and a loss because it's mainstay of a Coldplay album.
don't know if this has been discussed.
clueing for looks
matti said:
Yes, here. Search for color/colour to find posts about that topic.
thanks so apparently... "Midnight" is the color song.
If I remember correctly only a few people had that opinion. To me midnight isn't a colour. Or it should be midnight blue. Otherwise you can say that ink is a colour as well.
true. i wish the band clears it up once they release the album or we could ask the oracle perhaps.
Jonathanpeel
Come back come sing to me
Chris has said in the past that the colour song titles are just coincidence. I too think midnight could be the colour title but it seems doubtful considering ink could also be considered a title. What Chris has confirmed in the past though is that he tries to always have at least three songs on a album that starts with the same letter. This time being "A".
The Lonely Martian
Wait for your call, love
Yeah, I've never heard of "color songs" before. probably not that important! :lol:
The Lonely Martian said:
Have you been living under a rock?
Most Interesting Poster 2015
IIRC, it was brought up to the Oracle as well. I'm para-para-paraphrasing but the response was that it's not something the band goes out of their way to try and do. The oracle actually didn't count Charlie Brown as a "colour song" anyways.
Edit: Here's the Oracle post
April 16, 2013 / submitted by Angela, United Kingdom
Q. Hi Oracle !
I would like to know.. There's a colour song in each album:
- Yellow in Parachutes
- Green Eyes in AROBTTH
- White Shadows in X&Y
- Violet Hill in VLVODAAHF
- Charlie Brown in Mylo Xyloto
Did they do this on purpose or it's just a coincidence ?
The Oracle Replies
Total coincidence. Violet Hill is a place and Charlie Brown is a name so I don't associate either of those songs with their title's colour.
Tash said:
Nah, just haven't seen it being discussed before until now. Also, apart from having the name of a color in the title, why is it a thing, exactly?
Just another one of those little things the fandom can talk about, like CarKids and 42. Meaningless in the end, but good to kill time with in between albums
edit: oh god, wouldn't car kids be amazing as one of the exclusive target songs?!
See, ^ just like that, meaningless, unlikely but keeps the fandom running
jc90 said:
Just another one of those little things a fandom can talk about
Written In Graffiti
Missing The Mark
It's all coincidence, as the Oracle says. Violet Hill - violet as in the flower or the colour? And in that case, what came first - the colour orange or the fruit? I think people are looking into it a little too much.
Science and progress
Blue Dream, Celeste, Psyche in Silver
Back to the topic of the missing color name song in Ghost Stories, I was curious and I got in the website of Mila Furstova, the designer of the album covers, and I found out those names that makes me thing that could have been inspiration for Coldplay to some song titles, especially for the famous color name song of each album. So... thinking about the whole theme of the album and considering that there will be 3 bonus tracks, could those ones be those songs? And not only one color name song, even three color name songs? Or maybe they could be included as hidden tracks.
Take a look at these explanations:
- Blue: Blue is the colour of the clear sky and the deep sea. On the optical spectrum, blue is located between violet and green.
Surveys in the U.S. and Europe show that blue is the colour most commonly associated with harmony, faithfulness, and confidence. In U.S. and European public opinion polls it is overwhelmingly the most popular colour, chosen by almost half of both men and women as their favourite colour. It is also commonly associated with the sky, the sea, ice, cold, and sometimes with sadness.
- Celeste: Heaven (Latin caelum; tangi of caelum ': be-touched-struck by lightning) is often defined as the space in which the stars move and visual effect seems to surround the Earth. In astronomy, sky blue field stands for: an imaginary dome on which the Sun, stars, planets and the moon are distributed. The celestial sphere is divided into regions called constellations.
In mythology, among the Romans, the Latin name of the god Uranus and pre-Olympic deities.
- Psyche: In psychology, the psyche /ˈsaɪki/ is the totality of the human mind, conscious, and unconscious. Psychology is the scientific or objective study of the psyche. The word has a long history of use in psychology and philosophy, dating back to ancient times, and has been one of the fundamental concepts for understanding human nature from a scientific point of view. The English word soul is sometimes used synonymously, especially in older texts.
Don't you think that it all makes some sense?
DieProspekt
Yellow (Parachutes)
Green Eyes (AROBTH)
White Shadows (X&Y)
Violet Hill (Viva la Vida)
Charlie Brown (MX)
and ??? (Ghost Stories)
Something that makes no sense to the Coldplay fan.
MosesTheMarshmallow
You're a Sky Full of Stars
Blue song now!
Ink is Black.
Nature said:
...so...? You're not really suggesting because ink is black it should count as a 'colour song' are you?
Nowadays there are inks of lots of colors, so it could be but it looks like it is more generic. I'm starting to consider Midnight as the color song, as a dark blue almost black color, at least until they confirm which ones are the 3 bonus tracks or if there are some hidden tracks.
Again, why do we need a colour song at all? Is it purely desperation to keep the streak going? A streak Coldplay have denied existing intentionally anyways?
edit: For the record, Midnight would be a closer 'colour song' than Ink anyways.
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Wicca Wic"ca (w[i^]k"k[.a]), prop. n. [OE. wicche wizard, AS. wicce, fem., wicca, masc.; see also {witch} and {wicked}.] 1. A religion derived from pre-Christian times, also called {Witchcraft}[4], which practices a benevolent reverence for nature, and recognizes two deities, variously viewed as Mother & Father, Goddess & God, Female & Male, etc.; its practitioners are called Wiccans, Wiccas, or witches. Since there is no central authority to propagate dogma, the beliefs and practices of Wiccans vary significantly. [PJC]
Encouraged by court rulings recognizing witchcraft as a legal religion, an increasing number of books related to the subject, and the continuing cultural concern for the environment, Wicca -- as contemporary witchcraft is often called -- has been growing in the United States and abroad. It is a major element in the expanding ``neo-pagan'' movement whose members regard nature itself as charged with divinity. --Gustav Niebuhr (N. Y. Times, Oct. 31, 1999, p. 1) [PJC]
``I don't worship Satan, who I don't think exists, but I do pray to the Goddess of Creation.'' said Margot S. Adler, a New York correspondent for National Public Radio and a Wiccan practitioner. ``Wicca is not anti-Christian or pro-Christian, it's pre-Christian.'' --Anthony Ramirez (N. Y. Times Aug. 22, 1999, p. wk 2) [PJC]
Note: Wicca is a ditheistic religion, also called Witchcraft, founded on the beliefs and doctrines of pre-Roman Celts, including the reverence for nature and the belief in a universal balance. Though frequently practiced in covens, solitary practitioners do exist. The modern form of the religion was popularized in 1954 by Gerald Gardener's Witchcraft Today. It is viewed as a form of neo-paganism. Wicca recognizes two deities, visualized as Mother & Father, Goddess & God, Female & Male, etc. These dieties are nameless, but many Wiccans adopt a name with which they refer to the two: Diana is a popular name for the Goddess to take, among others such as Artemis, Isis, Morrigan, etc. Some of her symbols are: the moon; the ocean; a cauldron; and the labrys (two-headed axe), among others. The God is of equal power to the Goddess, and takes on names such as Apollo, Odin, Lugh, etc. A small number of his symbols are: the sun; the sky; a horn (or two horns); and others. Witchcraft is not a Christian denomination; there is no devil in its mythos, thus the devil cannot be worshiped, and the medieval view of Witches as Satan-worshipers is erroneous. Satanists are not Witches and Witches are not Satanists. Both have a tendency to be offended when the two are confused. In the Wiccan religion male Witches are not ``Warlocks''. The term Warlock comes from Scottish, meaning 'oathbreaker', 'traitor', or 'devil'. Its application to male witches is of uncertain origin. The Wiccan Rede, ``An it harm none, do what thou wilt'' comes in many variations. All of them say the same thing, ``Do as you wish, just don't do anything to harm anyone.'' It is implied that 'anyone' includes one's self. Witches practice in groups called Covens or as solitary practitioners, and some practice ``magic'', which is to say, they pray. Since the one rule that Witches have requires that they can not do harm, harmful magic does not exist in Wicca. In Wicca, ``magic'' is simply subtly altering small things, to gain a desired effect. Wicca, sometimes called Neo-Witchcraft, was revived in the 1950s, when the last laws against Witchcraft were repealed. Gerald Gardner founded Gardnerian Wicca sometime after his book, Witchcraft Today, was published in 1954. Raymond Buckland, in America, did much the same that Gardner did in Europe -- stood up to the misconceptions about Witchcraft. Two other books describing the modern practice of Wicca are: Wicca: A Guide for the Solitary Practitioner, by Scott Cunningham, Llewellyn Publications, 1988. Buckland's Complete Book of Witchcraft, by Raymond Buckland, Llewellyn Publications, 1975. [PJC]
2. A practitioner of Wicca, also commonly called a {Wiccan}, {Wicca}, or {witch} . [PJC]
For at least one person who has seen ``The Blair Witch Project'', the surprise hit movie of the summer did not so much terrify as infuriate. One long slur against witches, said Selena Fox, a witch, or Wicca, as male and female American witches prefer to call themselves. --Anthony Ramirez (N. Y. Times, Aug. 22, 1999, p. wk 2) [PJC]
Sorcery, necromancy, magic, witchery, thaumaturgy, theurgy, wonder-working, enchantment, incantation, conjuration, charm, spell, the black art
witched
Witchcraft — • As commonly understood, involves the idea of a diabolical pact or at least an appeal to the intervention of the spirits of evil Catholic Encyclopedia. Kevin Knight. 2006. Witchcraft Witchcraft … Catholic encyclopedia
Witchcraft — «Witchcraft» Сингл Pendulum из альбома Immersion Выпущен 18 июля 2010 года (цифровая загрузка) 19 июля 2010 года (CD сингл) 15 ноября 2010 года(винил) Формат CD сингл, загрузка, грампластинка Записан … Википедия
witchcraft — O.E. wiccecræft, from wicce (see WITCH (Cf. witch)) + cræft power, skill (see CRAFT (Cf. craft)). Witchcraft was declared a crime in English law in 1542; trials there peaked in 1580s and 1640s but fell sharply after 1660. The last, in 1717, ended … Etymology dictionary
witchcraft — witch craft (w[i^]ch kr[a^]ft), n. [AS. wiccecr[ae]ft.] [1913 Webster] 1. The practices or art of witches. [1913 Webster] 2. Hence: Sorcery; enchantments; intercourse with evil spirits. [1913 Webster + PJC] 3. Power more than natural;… … The Collaborative International Dictionary of English
Witchcraft — Allgemeine Informationen Genre(s) Doom Metal Gründung 2000 Website http://www.witchcrafthome.com/ … Deutsch Wikipedia
witchcraft — wizardry, witchery, sorcery, *magic, alchemy, thaumaturgy … New Dictionary of Synonyms
witchcraft — [n] spell casting, magic abracadabra*, bewitchment, black art, black magic, charisma, conjuring, divination, enchantment, hocus pocus*, hoodoo*, incantation, jinx, magnetism, mumbo jumbo*, necromancy, occult, occultism, sorcery, spell,… … New thesaurus
witchcraft — ► NOUN ▪ the practice of magic, especially the use of spells and the invocation of evil spirits. See also WICCA(Cf. ↑Wiccan) … English terms dictionary
witchcraft — [wich′kraft΄] n. [ME wicchecrafte < OE wiccecræft] 1. the power or practices of witches; specif., a) black magic; sorcery b) white magic 2. an instance of the use of black magic or white magic 3. bewitching attraction or charm SYN … English World dictionary
Witchcraft — For other uses, see Witchcraft (disambiguation). Witch redirects here. For other uses, see Witch (disambiguation). The classic image of the witch astride a besom broom … Wikipedia
witchcraft — /wich kraft , krahft /, n. 1. the art or practices of a witch; sorcery; magic. 2. magical influence; witchery. [bef. 950; ME wicchecraft, OE wiccecraeft. See WITCH, CRAFT] Syn. 1. See magic. * * * Introduction the exercise or invocation of… … Universalium
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Local News 27.6.2019 10:47 am
Knysna old age home residents attempt hunger strike in sympathy with caregivers
Nwabisa Pondoyi
The Vermont Centre has been thrown in the spotlight again.
Staff members say they are short-staffed and consequently overworked while also being underpaid, and alleging they have not received an increase or bonus in the past three years.
Vermont Old Age Home in Hornlee, Knysna is no stranger to controversy, with the latest being an attempted hunger strike by residents in sympathy with the centre’s “overworked and underpaid” caregivers and staff members, reports Kynsna-Plett Herald.
In February this year, the Vermont board of trustees suspended and subsequently fired centre manager Hendrik Blaauw over “dishonesty and failure to follow protocol regarding procurement policies”, among other charges. Board chairperson Mietjie Tities was later elected acting manager in Blaauw’s place.
A representative from the National Education, Health and Allied Workers’ Union (Nehawu), Simphiwe Guzi, spoke to Knysna-Plett Herald, explaining the frustration of staff members, who say they are short-staffed and consequently overworked while also being underpaid, and alleging they have not received an increase or bonus in the past three years.
ALSO READ: Pretoria old-age home strike leaves elderly neglected
Guzi said the union had been trying to meet with the management, but that all attempts to do so had been in vain thus far.
He explained that the centre’s residents, in solidarity with the staff, then decided to go on a hunger strike on June 16 until such time as management would listen to their grievances.
But this did not work either, Guzi said. “Although we appreciated the support, after a while we told them to eat because they are old and some take medication and therefore cannot afford to go without meals.”
A board member who wishes to remain anonymous also spoke to Knysna-Plett Herald last week, saying the centre had been struggling with funds and mentioning that money has gone missing and that, although Tities reported this to the board, the acting manager never opened a case with the police.
When Tities was asked for comment, she laughed and rubbished the allegations, adding: “There was never a protest action at the centre – a staff member told me about the protest action but when I had a meeting with the residents, I was told there is no such thing.”
When asked about the alleged missing funds, she refused to comment.
A resident representative, Clive Berry, said he was informed about the protest action in solidarity with staff, but referred to it as a “non-event” as nothing came of it.
For more news your way, download The Citizen’s app for iOS and Android.
Salary dispute forces Kempton Park child welfare to close 12.2.2019
AKA donates R100k, hands out food at Wits following hunger strike 11.2.2019
ANC welcomes ‘no holidays for Eskom employees’ 7.12.2018
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Early Detection – From our Anthology
Posted on October 10, 2015 October 9, 2015 by jac1216
“Mom, I’m sending the invites. I am so excited!” exclaimed Rita.
“Great, honey. The invitations are so cute!” Rita’s mother, Clara, responded. She smiled at her glowing daughter. Clara continued, “Are you finished with the early detection appointments, dear?”
Rita grinned, “I have one more appointment with Dr. Jorgensen, but I – and the baby – have passed all of the preliminary tests. We are healthy!”
“I can’t wait to meet my first grandchild,” said Clara.
Rita hugged her mother tightly, knowing that her little girl was loved.
Rita Stowell sat in the cold, white room at the Residential Clinic in section 17.F.1822 on City-State’s Layer Seven. It was a middle-class area mostly made up of B-Class citizens. Rita was content with her status and living quarters, but she was ecstatic about motherhood.
Rita was carrying her first child, and she was due in five weeks. This would be one of her last early detection appointments.
Early detection was an intricate part of City-State’s StarChild Program – an advanced medical program that screened and recognized fetuses for abnormalities, defects, and potential health problems.
In the waiting room, Rita tried not to look nervous. The young mother-to-be decided to watch the vid screen as she waited patiently for the doctor.
The vid screen on the wall blasted mindless entertainment. She was already into the third episode of “Working Girls”, a reality television show about young ladies “feverishly employed” in City-State’s Entertainment District. At first, she found the entire idea of the show repulsive. But after two episodes, she was hooked. What else is a D-Class girl going to do? Violet Bluebell had to pay the bills.
Rita laughed and patted her belly. “This show is ridiculous,” she murmured to herself. A working girl life would not be the life for her daughter. Rita quietly continued, “My daughter is going to be an S-Class engineer or at least an A-Class entrepreneur. She will not be damned to be ‘glass house’ entertainment for City-State’s perverted consumers.”
“Rita Stowell,” articulated a petite nurse. She wore light blue scrubs. The upper left-hand side of her scrub top showcased an embroidered symbol: City-State’s Seven Point Star.
Rita drew her attention away from the vid screen and focused on the nurse. “Yes, that’s me,” she said.
The kind-looking nurse showed Rita to a private room. Rita patiently waited for the doctor for several minutes while her legs stuck to the sanitary paper on the table.
The door finally opened, and Dr. Jorgensen entered. He carried his MediPalm device in his right hand. He tapped the screen for a moment before looking up at Rita.
“Hello, Rita, how are you today?” Jorgensen asked vacantly.
“I’m doing alright, I guess,” Rita replied. “I am so excited to be a mother. I can’t wait to meet my little girl!”
“That’s the right idea, Rita,” reassured the doctor. “It is best to stay positive throughout this entire situation.”
“Oh, I do!” Rita proclaimed. “I can’t wait to watch her grow – to learn and to see what she what she will become.” Rita smiled.
“So you will keep trying to have a girl, right? That’s good. Girls are very cute.” Dr. Jorgenson’s voice sounded hollow, harsh, and ominous.
“Wait. What?” questioned Rita. She was immensely confused. “What are you talking about? I am having a girl.” Rita pointed to her belly. “What do you mean ‘keep trying?’ The ultrasound showed…”
Dr. Jorgensen sighed; he placed his MediPalm on the table next to Rita. He gave her a sympathetic look, but his voice did not waver when he replied.
“Rita,” he said coldly. “This pregnancy is being terminated. I thought you knew that.”
“What?!?” Rita screeched. The young mother felt as if she was impaled by a hot iron. Her chest was tight, and her breathing became irregular. “What? What do you mean? This is a mistake!”
“It’s no mistake, Rita,” said the doctor. “Our final exams of the fetus showed that it has a 47% chance of early heart disease, breast cancer, and depression. StarChild parameters dictate that this pregnancy is to be terminated immediately. Did you read the UniSys message we sent you? This appointment is for…”
“I didn’t read any message!” exclaimed Rita. She clenched her teeth and buried her head in her small, soft hands. Her nails scratched at her forehead and cheeks.
Tears filled Rita’s bloodshot eyes. Her breath was ragged, and her face contorted. “Please! This can’t happen!” She screamed, wishing for the sound of her voice to crush the heartless doctor’s head.
The readout was incorrect. It had to be. There was no history of any kind of illness in her family.
Rita pleaded with the doctor, “It was wrong! You are wrong!” she pleaded. The world fell away. Her heart accelerated. Each pounding thump crushed her dream of motherhood.
The doctor spoke to Rita as if she was a young, naïve child. His tone was calm and firm like an elementary school teacher: “Rita, I understand how you must feel, but remember, City-State requires us to share the sacrifice if we are to remain a civilized society.”
“What? A civilized society? The StarChild Program is far from civilized!” Rita launched her fists wildly at the doctor’s face.
Dr. Jorgensen dodged the infuriated woman’s blows. “There is no appeals process for this, Rita. The computer makes the call. It’s never wrong.”
Rita finally connected her fist to the man’s face with a satisfying “crack”. Dr. Jorgensen hurried out of the room and shut the door. Rita heard it lock behind him.
Rita ran to the door, and she pounded it with solid, repetitive blows. She screamed uncontrollably for several minutes with deep, guttural, raw, primordial sounds. “I hate you! I hate this place! I want to go home!”
A few minutes of sobs followed the screams. Rita heard the door unlock. Immediately, she backed away like a frightened child. The young mother expected the doctor, but four agents from the Federal Economic Advisory Board (FEAB) entered the room with stun batons.
Her fear boiled into rage; she charged at the agents with her fists closed, trying to save her child, but she was outnumbered. The stun batons found their mark on the side of her head, her chest, and her neck. The room went black.
When Rita awoke, she stared at the harsh, fluorescent lights of the recovery room. She could hear the gentle sobs of other women around her, and her vision was blurred.
After a few moments, Rita shook her head and rubbed her eyes. She placed her hand on her stomach. It had decreased in size, and it was soft – it was empty. She fully comprehended the situation: they took her baby.
A wave of unfathomable sorrow swept over her as she joined in the quiet weeping around her. Rita’s heart was broken; she could not breathe. After a few seconds, she gasped for breath. Her bloodcurdling screams pierced the silent, white halls of the clinic.
A representative from the hospital’s administration staff approached Rita with a MediPalm. “Hello, Rita. I’m from records. Can you please sign this termination acknowledgment? It’s normal protocol.”
Rita violently slapped the communication device out of the hospital representative’s hands. The crash startled Rita’s nurses.
“Please, Ms. Stowell,” said the unsympathetic staffer as she recovered the MediPalm. She held it out to Rita with shaking hands. “You have to sign. It will be alright.”
The staffer paused, looked at Rita, and hesitantly continued, “Why do you cry, Ms. Stowell?”
Rita snatched the MediPalm from the staffer. “Fine! I’ll sign it. Murder by decree – it is still murder!”
“Ms. Stowell, technically it is just a fetus, and it…”
Rita’s icy stare silenced the rest of the staffer’s sentence. Her bloodshot eyes betrayed madness. “You killed my baby.”
Rita ripped two IVs out of her right upper forearm and snatched the MediPalm from the hospital worker. With an unsteady hand, Rita began to sign her child’s death certificate.
“Goodbye, Gracie. Mommy loved you so much,” Rita sobbed uncontrollably as she finished her signature. “I will never forget you, baby.
Posted in Dystopian, Fiction, Horror, LiteratureTagged abortion, choice, defund, defund pp, every life matters, life, planned parenthood, pro choice, pro life, stand with pp, women's rights
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5 thoughts on “Early Detection – From our Anthology”
I enjoyed reading this piece very much! The pain of the young mother is well-communicated. Is this short part of a new anthology?
jac1216 says:
It is actually part of the first Anthology.
Oh, okay! 🙂
williamchasterson says:
You have been nominated for the Liebster Award!
https://williamchasterson.wordpress.com/2015/10/13/the-liebster-award/
relationspdbeverly says:
Great beginning to your story! I hope nothing like this ever comes to pass in reality!
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