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__label__wiki	0.91072	0.91072	Euphoria’s Costume Designer “Tried to Be Aware of What Is Heteronormative” When Dressing Rue Heidi Bivens tells InStyle about the meaning behind the outfits from the hit HBO show. By Samantha Sutton What do you get when you cast a former Disney star in a show that’s filled with drugs, sex, and intense teenage drama? Something that’s equally terrifying as it is addicting. We’re talking about HBO's Euphoria, which stars the talented Zendaya alongside the likes of Hunter Schafer, Sydney Sweeney, and Maude Apatow (just to name a few). It’s real and raw in every sense of the word, but aside from the it’s-scary-because-it-happens storylines, we find ourselves obsessing over the outfits each and every episode. There was Kat’s transformation from background BFF to badass dominatrix; Maddy’s full wardrobe of crop tops and revealing cutouts; and Rue’s overall laid-back vibe, which keeps us searching for similar Bermuda shorts and button-downs. All of it comes from the brain of Heidi Bivens, Euphoria’s skilled costume designer, who previously worked on films such as Spring Breakers and Mid90s. “When I’m working on costumes for a project, I spend a lot of time trying to mentally occupy the world of the story,” she exclusively reveals to InStyle over email. “I create a filter that all my ideas run through — a list of questions I ask myself about where each character gets their clothes, what colors they gravitate towards, what music they listen to, and how important things like comfort and style are to them.” That type of attention to detail is definitely noticeable on-screen, and each character has a distinct signature style. Ahead, Bivens lets us in on the work that went behind some of Euphoria's best looks, including where she draws inspiration and the messages she's trying to send. RELATED: Why Tai’s Club Look Is the Best Outfit From Clueless On Rue’s overall style: “While designing the show, I’ve really tried to be aware of what is heteronormative and not fall into stereotypes of what is considered traditionally masculine and feminine. Rue is a character who likes to be comfortable and while she has a distinct personal style, it comes naturally to her. She has been consistent with her style since she was old enough to dress herself; she is clear in her mind about what she likes.” On whether or not her outfits reflect her mental state: “Not really, except for dream states or scenes which reflect her inner-state, like the scene in classroom where Rue is describing the different kinds of ‘dick pics’ one might receive while wearing a burgundy, maroon-colored jumpsuit. It’s like a uniform, almost military in style, as she’s leading the classroom with air of authority.” On Jules dressing like Sailor Moon: “I definitely thought of anime in general when I first started coming up with the looks that we first see Jules in. But then, as the season progresses, she starts to dress more for herself and less cutesy-femme for boys and men’s attention. I try to glean inspiration from enough different directions and references that what I come up with isn’t too derivative of any one person, place, or thing.” On that Kappa windbreaker that made an appearance on the show: “I found it at a thrift store and loved the green and blue color combo. It’s a vintage piece that Jules could have found at a thrift store as well, and she would have bought without any real idea that it is a soccer brand.” On Maddy’s sexy carnival look: “I wanted to come up with a look that did everything it needed to do on first glance. Maddy is confident, but Nate tells her she looks like a ‘hooker’ and to go home and change. He tries to shame her, but she doesn’t let him and is empowered anyway. Her style in general is one that is very polished, put-together, and meditative — she spends time working on her looks. When we see her in episode five looking disheveled, that is a direct reflection of her mental state. But in general, she sees herself as queen bee.” On Kat’s style transformation: “In the beginning of the season, Kat wears a lot of vintage and was inspired by Thora Birch’s character in Ghost World. When she starts coming into her own and feels empowered, she starts to wear latex and leather, a direct indication of her interest in BDSM.” On teen movies that inspired the costume choices: “Maybe somewhere in my subconscious is some early Gregg Araki films, but in general, all my references printed on the wall of the costume office were modern pictures of teens today. Instagram is a goldmine for current style references and inspiration.” On the outfits to keep an eye out for: “The Winter Formal in episode seven has some iconic looks!”	cc/2020-05/en_middle_0111.json.gz/line2659
__label__cc	0.605685	0.394315	Home NEWS Energy Walk: Not to Save Fuel But Generate Electricity Walk: Not to Save Fuel But Generate Electricity Energy Featured NEWS Christy Gren , November 9, 2017 / 3249 0 In London’s West End there was an underutilized path which later transforms into world’s first energy-harvesting smart street. The entire street is made from PaveGen’s power-generating pavement. The clean-tech company has installed in the Bird Street a 107-square-foot array in order to convert footsteps into electricity. The arrangement also includes Bluetooth Low-Energy transmitters for the users to interact with it via apps. The apps will also show how much energy their footsteps are harvesting which will translate into gift vouchers, discounts and most importantly, clean energy. PaveGen installed a custom flooring system with wireless transmitter that allows it collect the data from the tiles. The generators below produce kinetic energy as people walk over it. The pressure from the walk causes the generators to vertically displace. This electromagnetic induction produces kinetic energy which helps provide electric power. The fact that it is situated on Bird Street, PaveGen has made the flooring to power the chirps of the birds. PaveGen’s power-generating pavement. PaveGen and Google project in Berlin In recent news, Google collaborated with the UK based PaveGen, an energy harvesting pioneer to come up with something new for Berlin’s 2017 Festival of Lights. The event had taken place over a span of 10 days. For the same, Google and PaveGen created an interactive energy-harvesting walkway and light show. They installed a smart floor along with 176 colored light panels. The installation makes use of V3 flooring. The particular flooring helps convert the kinetic energy generated from the footsteps into off-grid energy and data. The walking created an orchestrated lighting display. The wall became more responsive after the frequency of people walking on it created more energy. Big Talks Project Lead and Head of PaveGen, Archie Wilkinson told Digital Trends, “The generator technology is electromagnetic, like a bicycle dynamo, and converts the kinetic energy from your footstep into off-grid electricity.” He further adds, "As you step on the PaveGen floor, the top surface flexes by 5-10mm, creating a rotation in the electromagnetic generators below. Each step produces around 3 joules of energy, which is about 5 watts for the duration of each step. The walkway has already generated over 100,000 joules of energy since launch on Wednesday, October 10.” Based in the United Kingdom, PaveGen has been into customising multifunctional flooring systems. Found in 2009, Laurence Kemball-Cook, a graduate in Industrial Technology and Design from Loughborough University is the mastermind behind this venture. PaveGen creates flooring systems that convert the movements of the people on the tiles. This helps generating vertical displacement of the electromagnetic induction generators. This in turn results in a rotational motion which generates off-grid electricity. PaveGen has surely paved a new route to not only a healthy but a pollution-free environment after coming up with this kind of energy-harvesting array. This not only makes people use less vehicles for conveyances but also generate electricity with a renewable source that can make cities more brighter and less polluted. An Egg-Shaped Micro Home Built for Off-the-grid Li... What Makes Indra Nooyi a Great Leader? The Single Biggest Clue About Google’s Future Hidd... Marriott Starwood Merger Creates World's Biggest H... Google Huawei Lawsuit to Tackle the Issue of Bootl... Google’s new app helps user to keep track of their... Uber is expanding its horizon in remote places in ... Introvert Leaders Vs Extrovert Leaders: Review of ... Tags: Festival of Lights, Google green energy, green energy, kinetic energy, PaveGen, PaveGen and Google 2019 Chevrolet Corvette: The Brand’s Most Powerful Vehicle Will the US put the lights out in the waning Coal Industry? Anna Domanska, November 10, 2016 How will Trump’s Win Impact 2016 Holiday Spending Snapchat Earnings and Growth Slump are Warning Bells for the Social Media Company Christy Gren, November 4, 2017 The limited edition ABT Audi Q7 to only have only 10 of its kind Apple iPhone 11 launch date is closer than you thi... New Skype link-sharing feature allows anyone to jo... Vienna tops EIU’s ranking of Most Livable Cities i... What Separates Highly Successful People from the a... Marketing Diaries: The Greatest Tech Business Riva... Apple Is No Longer Worth One Trillion Dollars Toyota Forms Data-Centric Company ‘Toyota Connecte... Didi Chuxing Planning to Consider $6 billion Inves...	cc/2020-05/en_middle_0111.json.gz/line2669
__label__cc	0.728675	0.271325	Thrombosis/embolism Michael Streiff Venous thromboembolism (VTE) refers to venous thrombosis involving the deep (deep venous thrombosis or DVT) or superficial vessels (superficial venous thrombosis or thrombophlebitis) of the upper and lower extremities and central venous vessels (e.g., inferior and superior vena cava) and pulmonary emboli (pulmonary embolism [PE]) that migrate to the lungs from these locations. A Center for Disease Control analysis of National Hospital Discharge Survey data from 2007 – 2009 estimated that 547,596 hospitalizations occurred annually among persons aged >= 18 years for VTE; 348,558 for DVT, 277,549 for PE and 78,511 for DVT and PE. These correspond to average annual rates of hospitalization for VTE of 239 per 100,000 population, 152 per 100,000 population for DVT and 121 per 100,000 for PE (Yusef H et al. MMWR 2012). These data are underestimates as they do not include patients treated as outpatients. The risk of VTE is very low among children, intermediate among young and middle aged adults and high among older adults. The incidence of VTE appears to be ~ similar between men and women. Ethnicity strongly influences the risk of VTE. African Americans have the highest annual incidence followed closely by Caucasians while the incidence is significantly less among Latinos and Asians (see Table I) Table I.n Demographic VTE Risk Factors The most important risk factors for VTE are: medical illnesses (see below) (Medical illnesses such as stroke, myocardial infarction, congestive heart failure, respiratory failure, infections, rheumatologic disorders (e.g., systemic lupus erythematosus), and inflammatory bowel disease.) (See Table II) Table II.n Acquired Risk Factors for Venous Thromboembolism Major surgery (requiring hospitalization) is associated with a 70-fold increased risk of VTE in the first 6 weeks post-operation. The increase in risk has been documented to last up to 12 months post-operation, although the highest period of risk is in the first 2 weeks after surgery. The risk of VTE varies by type of surgery and the duration of the operation. Neurosurgery and cardiothoracic surgery are associated with the greatest risks for VTE. Ambulatory surgery (outpatient surgery) increases the risk of VTE by 10-fold. 58% of major trauma patients (Injury Severity Score > 9) developed a DVT on routine venography performed 14 – 21 days post-injury and 18% had proximal DVT. Asymptomatic PE can be detected by CT angiography in 24% of moderately and severely injured trauma patients within 1 week of injury. Fatal PE is responsible for 12% of deaths in hospitalized trauma patients. Active cancer increases the risk of VTE by 4- to 7-fold. Chemotherapy in a cancer patient is associated with a 2- to 6-fold increased risk. The risk of VTE varies by cancer type with pancreatic, brain and gastric cancers having the highest risk, lung cancer and lymphoma a somewhat lower risk, and prostate and breast cancer being among the lowest thrombotic risk categories. Metastatic disease is associated with a 1.5- to 20-fold higher risk than regional or localized disease. Surgery, erythropoietic stimulatory agents and central venous catheters also contribute to the increased risk of VTE in cancer patients. Inherited and acquired thrombophilia increases the risk of VTE by 2- to 20-fold depending upon the thrombophilic condition. High risk inherited thrombophilic states include antithrombin (15- to 20-fold increased risk), protein C (15- to 20-fold), and protein S deficiency (15- to 20-fold). Moderate risk inherited thrombophilic states include factor V Leiden (5- to 7-fold), elevated factor VIII levels (3- to 5-fold), and the prothrombin gene 20210 mutation (2- to 3-fold). Low risk inherited thrombophilic states include elevated factor IX levels (1.5- to 2.5-fold), elevated factor XI levels (1.5- to 2.5-fold), and hyperhomocysteinemia (1.5- to 2.5 fold, except in cases of homocystinuria where the risk is much higher). Antiphospholipid syndrome is an acquired thrombophilic state associated with a variable risk of thrombosis (3- to 10-fold) depending upon the associated laboratory abnormality establishing the diagnosis. In the Sirius Study of VTE risk factors in medical outpatients, immobilization was associated with a 6-fold increased risk of VTE Medical Illnesses Medical illnesses such as stroke, myocardial infarction, congestive heart failure, respiratory failure, infections, rheumatologic conditions, and inflammatory bowel disease all increase the risk of VTE by 2- to 10-fold The presence of a DVT is often indicated by the development of pain, swelling, and erythema in the affected extremity. A feeling of heaviness in the leg or the sensation of a leg cramp that does not go away are common complaints. Pulmonary embolism classically results in the sudden onset of dyspnea and pleuritic chest pain, although some patients present with gradually worsening dyspnea or back pain. Syncope or pre-syncope is an ominous presentation of PE that usually indicates a large embolic burden. Mesenteric vein thrombosis can present acutely with severe abdominal pain and vomiting due to intestinal ischemia, or chronically with signs and symptoms of portal hypertension that include variceal bleeding, ascites, and splenomegaly. Hepatic vein thrombosis presents with abdominal pain, distention, and ascites. Cerebral vein thrombosis typically presents with severe headache, nausea, vomiting, and visual impairment. Diagnosis of venous thrombotic disorders relies upon imaging studies. Pre-test probability models such as the Wells criteria have been developed to exclude DVT and PE in conjunction with sensitive D-dimer tests (see Table III and Table IV), but duplex ultrasonography and CT angiography remain the cornerstone of deep venous thrombosis and pulmonary embolism diagnosis. Table III.n Wells Clinical DVT Model Table IV.n Wells Clinical Pulmonary Embolism Model Duplex ultrasound is also useful for diagnosis of upper extremity, thoracic, and jugular vein DVT. In some instances, computed tomography (CT) venography may be necessary for diagnosis of thrombosis in intrathoracic vessels that are not amenable to compression (e.g., the subclavian vein and superior vena cava). Therefore, CT venography should be employed when diagnostic suspicion is high in the setting of a negative duplex study. Upper extremity thrombosis is often due to the presence of central venous catheters or anatomic compression (thoracic outlet syndrome [TOS] or tumor/nodal masses). In the absence of an identifiable cause of upper extremity (axillary-subclavian vein) thrombosis, the presence of thoracic outlet syndrome should be investigated with duplex ultrasonography or CT venography performed with the arm in stress positions. Failure to identify patients with TOS can result in recurrent axillary-subclavian vein thrombosis and post-thrombotic syndrome (PTS). Although duplex ultrasound (US) can sometimes be useful for iliac vein and inferior vena cava (IVC) thrombosis, CT angiography is more sensitive for thrombosis in these central veins. It is important to consider CT angiography when evaluating a patient with iliofemoral DVT who may have May-Thurner (iliac vein compression) syndrome. Hepatic duplex and CT angiography are useful for mesenteric vein (portal vein, superior mesenteric vein, etc.) and hepatic vein thrombosis. CT venography and magnetic resonance venography (MR venography) are the studies of choice for cerebral vein thrombosis. All patients with cerebral vein thrombosis should also have a dedicated ophthalmologic exam to ensure that visual complications of an elevated intracranial pressure are diagnosed and treated promptly. What features of the presentation will guide me toward possible causes and next treatment steps? The duration of therapy and decisions on adjunctive therapies for VTE (i.e., pharmacomechanical catheter-directed thrombolysis) are influenced by: the extent and location of the VTE the presence or absence of situational or persistent thrombotic triggers. Therefore, it is imperative to investigate the cause of the thrombotic event during the initial patient evaluation. Extensive extremity DVT should prompt consideration of catheter-directed thrombolysis, as patients with extensive proximal thrombosis rarely achieve complete clot lysis and are at high risk for post-thrombotic syndrome. The benefits of thrombolysis must be weighed against the higher risk of bleeding associated with this therapy. In the CAVenT study, catheter-directed thrombolysis (CDT) was associated with iliofemoral patency at 6 months of 66% compared to 47% in patients receiving anticoagulation alone (p=0.012). PTS developed in 41% of CDT-treated patients compared to 56% of anticoagulation alone patients (p=0.047). The result of the soon to be completed ATTRACT trial should provide important supplemental data to assist in decision-making in regards to the risks and benefits of CDT. Massive pulmonary embolism warrants systemic or ultrasound-assisted thrombolysis or catheter or surgical thrombectomy. The benefits of thrombolytic therapy in lower risk patients remain unclear. The PEITHO study, a randomized controlled trial of tenecteplase or placebo plus systemic anticoagulation in patients with intermediate risk PE, did not identify an improvement in all-cause mortality with thrombolysis (1.2% vs. 1.8% OR = 0.65, 95% CI 23 – 1.85). Furthermore, thrombolysis was associated with a 5.6-fold (6.3% vs. 1.2%, 95% CI 2.3 – 13.39) increase in major extracranial bleeding and a 12.2-fold (2.4% vs. 0.2%, 95% CI 1.57 – 93.39) increase in stroke. Triggered episodes of VTE occur in close temporal proximity to the inciting stimulus. Surgical and medical hospital-acquired VTE generally occur within 3 months of the procedure/hospitalization. The risk is highest in the first few weeks and then declines thereafter. Travel-associated VTE occurs within 8 weeks of the travel. Since travel is a weak risk factor for VTE, it is important to consider other possible risk factors for VTE that may be present and influence the ongoing risk of recurrence. Pregnancy: the risk of VTE rises during the antepartum period and peaks shortly after delivery with risk declining toward baseline by 6 – 12 weeks post-partum. Hormone associated thrombosis occurs during exposure and risk declines within 6 – 12 weeks of discontinuation. Cancer and its treatment place patients at high risk for VTE as long as detectable cancer remains or treatment continues. Patients with triggered VTE require a limited duration of therapy (at least 3 – 6 months, after which therapy may be discontinued if the stimulus is no longer present). If the trigger is still present (hormonal therapy, poorly controlled inflammatory bowel disease, cancer) then therapy should continue until it is absent or under adequate control. I generally treat patients with pulmonary embolism at least 6 months (rather than 3 months), as patients with PE are at higher risk for recurrent PE than patients with an initial DVT. Furthermore, PE has a higher case fatality rate than DVT (12% versus 6% 30-day mortality). Patients with unprovoked VTE should be considered for long-term anticoagulation, as they are at high risk for recurrence. Two risk stratification models, the Ottawa (Men Continue and HER DOO2) model (see Table XI) and the Vienna model, can be used to estimate the risk of recurrence in patients with idiopathic VTE, and to identify patients at sufficiently low risk that continuation of anticoagulation may have marginal benefits. It is important to note that these models require validation. There is a free web calculator for the Vienna prediction model for recurrent VTE, available at http://cemsiis.meduniwien.ac.at/en/kb/science-research/software/clinical-software/recurrent-vte/ Table XI.n The Ottawa VTE Risk Assessment Model for assessing the risk of recurrent VTE in patients with idiopathic VTE The potential presence of an underlying malignancy should always be considered in middle-aged patients (age 50 years or older) with idiopathic VTE. In addition to a complete history and physical examination, age-appropriate cancer screening should be undertaken in these patients. Limited screening would consist of a complete history and physical exam, as well as standard laboratory tests (complete blood count [CBC], comprehensive metabolic profile, stool hemoccult, urinalysis) and age-appropriate cancer screening (e.g., colonoscopy, mammography). Any abnormal findings on routine evaluation warrant additional investigation. Extensive screening with CT or PET-CT has not been demonstrated to improve early cancer detection in patients with unprovoked VTE. Patients with symptomatic calf DVT should receive at least 6 weeks (preferably 12 weeks) of anticoagulation. Patients with proximal superficial venous thrombophlebitis (greater saphenous vein in the thigh) or persistent distal superficial venous thrombophlebitis should be treated with anticoagulation rather than initial non-steroidal anti-inflammatory drugs. In patients with acute symptomatic SVT, fondaparinux 2.5 mg daily for 45 days reduced the incidence of progressive SVT, DVT or PE (0.9% versus 5.9%, RRR 85%) compared with placebo. Recurrent unprovoked superficial thrombophlebitis should prompt consideration of malignancy as an underlying cause. Recurrent VTE in the presence of therapeutic anticoagulation (INR 2 – 3) should prompt consideration of malignancy (Trousseau’s syndrome), antiphospholipid syndrome, paroxysmal nocturnal hemoglobinuria, myeloproliferative neoplasms (particularly polycythemia vera), heparin-induced thrombocytopenia, or local vascular compression (May-Thurner syndrome, thoracic outlet syndrome). Patients who present with left iliofemoral DVT should be investigated for May-Thurner (iliac vein compression) syndrome, as failure to re-establish in-line flow and stent the affected venous segment predisposes the patient to a high risk of locally recurrent VTE and post-thrombotic syndrome in the affected limb. Patients who present with upper extremity VTE must be investigated for an anatomic cause (central venous catheter, thoracic outlet syndrome, vascular compression by tumor/lymph nodes), as idiopathic thrombosis is unusual in this location. Patients who present with intra-abdominal thrombosis (mesenteric vein thrombosis, hepatic vein thrombosis) in the absence of a recent intra-abdominal surgical procedure should be investigated for a myeloproliferative neoplasm (e.g., polycythemia vera, essential thrombocythemia), intra-abdominal malignancy, a thrombophilic disorder, or paroxysmal nocturnal hemoglobinuria. Patients with cerebral venous sinus thrombosis should be investigated for the presence of an underlying myeloproliferative neoplasm such as polycythemia vera and essential thrombocythemia. The presence of paroxysmal nocturnal hemoglobinuria should be ruled out. It is important to assess carefully patients with cerebral venous sinus thrombosis for signs and symptoms of increased intracranial pressure, and to treat this aggressively. Subtle visual deficits can progress to life-altering visual loss unless diagnosed early. Therefore, we routinely test visual acuity in these patients and have them formally seen by neuro-ophthalmology at diagnosis. All patients with VTE should have routine laboratory testing (CBC with platelet count and differential, comprehensive metabolic profile, prothrombin time [PT], activated partial thromboplastin time [aPTT]) to rule out the presence of an underlying medical disorder. In young women of child-bearing age, pregnancy tests should be obtained prior to radiologic studies that may be harmful to the fetus. This information will also be critical for selection of appropriate treatment options. Diagnosis of VTE relies heavily upon objective imaging studies. Pre-test probability models such as the Wells criteria have been developed to exclude DVT and PE in conjunction with sensitive D-dimer tests, but duplex ultrasonography and CT angiography remain the cornerstone of deep venous thrombosis and pulmonary embolism diagnosis. Duplex is also useful for diagnosis of upper extremity, thoracic, and jugular vein DVT. In some instances, CT venography may be necessary for diagnosis of thrombosis in intrathoracic vessels which are not amenable to compression such as the subclavian vein and superior vena cava. Therefore, CT should be employed when diagnostic suspicion is high in the setting of a negative duplex study. Upper extremity thrombosis is often due to the presence of central venous catheters or anatomic compression (thoracic outlet syndrome [TOS] or tumor/nodal masses). In the absence of an identifiable cause of upper extremity (axillary-subclavian vein) thrombosis, the presence of thoracic outlet syndrome should be investigated with duplex ultrasonography or venography performed with the arm in stress positions. Failure to identify patients with TOS can result in recurrent axillary-subclavian vein thrombosis. Although duplex ultrasound (US) can sometimes be useful for iliac vein and IVC thrombosis, CT venography is more sensitive for thrombosis in these central veins. It is particularly important to consider CT venography when evaluating a patient with iliofemoral DVT who may have May-Thurner (iliac vein compression) syndrome. Hepatic duplex and CT venography are useful for mesenteric vein (portal vein, superior mesenteric vein, etc.) and hepatic vein thrombosis. CT venography and magnetic resonance venography are the studies of choice for cerebral vein thrombosis. All patients with cerebral vein thrombosis should also have a dedicated ophthalmologic exam to ensure that visual complications of elevated intracranial pressure are diagnosed and treated promptly. What conditions can underlie thrombosis/embolism: VTE is often triggered by abnormalities in one or more of Virchow’s Triad: stasis, hypercoagulability of the blood, vessel wall abnormalities. Therefore, the presence of potential disorders that may influence one or more elements of Virchow’s Triad should be considered in the evaluation and management of every patient with VTE. Elimination of any removable risk factor will reduce the risk of recurrence after an initial course of anticoagulation is completed. The presence of ongoing risk factors warrants consideration of long-term therapy. Stasis: recent immobility-travel (within 8 weeks), hospitalization (within 12 weeks), surgery (within 12 weeks or, possibly, longer), stroke (within 12 weeks), presence of anatomic vascular compression- thoracic outlet syndrome, effort thrombosis, May-Thurner syndrome, tumor or nodal masses obstructing flow, central venous catheter disrupting blood flow, pregnancy. Hypercoagulability: cancer, surgery – inpatient>outpatient, major trauma, pregnancy, exogenous hormonal agents, chemotherapy, erythropoietic stimulatory agents, thrombophilia, inflammation associated with infections, rheumatologic diseases, inflammatory bowel disease. Vessel wall damage: surgery – inpatient>outpatient, major trauma, central venous catheters, chemotherapy. Since the setting in which a thrombotic event occurs is the best guide to the appropriate duration of therapy, the need for thrombophilia testing is considerably less now than a few years ago. In general, if thrombophilia testing is not going to change therapy there is no compelling reason to perform it. The most common reason for thrombophilia testing in my experience is the desire of patients or their physicians to identify the etiology of a thrombotic event. However, I try to dissuade patients from pursuing thrombophilia testing unless it will significantly influence their treatment. Testing asymptomatic family members should be discouraged. Idiopathic venous thromboembolism Patients with idiopathic VTE are best treated with long-term therapy. Therefore, the only reason to perform thrombophilia testing in this instance would be to determine if a patient who wishes to discontinue therapy should be advised against this option due to a high risk for recurrence. Tests that could be ordered in this situation would include testing for the antiphospholipid syndrome including anticardiolipin antibodies, anti-beta-2 glycoprotein-I antibodies, and lupus anticoagulant/inhibitor testing including an aPTT using a low phospholipid reagent (i.e., Actin FSL, etc.) and a dilute Russell’s Viper venom time with Confirm procedure (and other tests for a lupus inhibitor). In young patients (age < 40 years) with a positive family history of VTE (in a first degree relative), inherited thrombophilia could be considered (although it has not been proven to improve outcomes)- factor V Leiden evaluation (APC Resistance assay with reflex factor V Leiden DNA testing if activated protein C [APC] resistance assay is positive), prothrombin gene mutation, protein C, protein S and antithrombin activity levels. Patients with antithrombin, protein C and protein S deficiency are thought to be at increased risk for recurrence, as are patients with homozygous factor V Leiden or the prothrombin gene mutation or compound heterozygotes for these defects. Alternatively, there are data supporting use of clinical prediction rules such as the Ottawa (Men Continue and HER DOO2) or Vienna Risk Criteria that incorporate patient and clinical characteristics and D-dimer levels on or off therapy in order to determine recurrence risk. While these risk scores need to be validated, they would seem to be the best strategy to use when deciding upon therapeutic duration in patients with unprovoked VTE. Young women with venous thromboembolism who may become pregnant Thrombophilia testing may be of benefit in young women with VTE who may become pregnant in the future, as the presence of thrombophilia may warrant more aggressive thromboprophylaxis during pregnancy – especially in women with a triggered episode of VTE. Heparin-induced thrombocytopenia testing Testing for heparin-induced thrombocytopenia (HIT) should be employed only if the diagnosis is suggested by the clinical situation (e.g., thrombocytopenia or thrombosis during heparin therapy). Pre-test probability models (i.e., the 4T’s score and the HIT expert probability [HEP] score) should be used to determine the probability of HIT before sending confirmatory laboratory testing Testing for other clinical entities Testing for clinical entities such as paroxysmal nocturnal hemoglobinuria and myeloproliferative neoplasms (e.g., JAK2 testing) should be done in patients with clinical features supporting diagnostic suspicion (thrombosis in mesenteric or hepatic veins, cerebral venous system, and supportive laboratory data for the diagnosis) I do not recommend use of tumor markers for screening patients with VTE for underlying malignancies because they are expensive and have not been demonstrated to improve survival in patients with malignancy-associated VTE. The diagnosis of VTE continues to rely upon confirmatory radiologic imaging studies despite the availability of pre-test probability models such as the Wells criteria and D-dimer testing. In large part this is due to the varying positive test thresholds for different D-dimer assays, local validation of positive test thresholds, and the medical-legal practice environment in the United States. Duplex ultrasound is very sensitive (95%) and specific for the presence of proximal extremity DVT or superficial venous thrombosis. Sensitivity and specificity decline in the distal extremity veins (approximately 75% sensitive and specific in the calf deep veins). Duplex ultrasound is also useful for the diagnosis of portal and hepatic vein thrombosis. In locations where compression cannot be used in the examination (subclavian and iliac veins, inferior and superior vena cava), CT venography should be employed if diagnostic suspicion is high in the event of a negative duplex study. CT venography is also sensitive for diagnosis of intra-abdominal venous thrombosis. CT venography/CT angiography (CTV/CTA) are sensitive and specific for diagnosis of venous thrombosis in all locations, albeit more invasive than duplex ultrasound. CTA is the diagnostic study of choice for PE. CTV is an excellent diagnostic study for cerebral venous sinus thrombosis, although MR venography is preferred by some physicians. MR venography is useful for diagnosis of venous thrombosis. It is used preferentially for cerebral venous sinus thrombosis and pelvic vein thrombosis in some centers. Thus far, it does not appear to be as sensitive for PE as CT angiography. MR direct clot imaging is a new technique that has been demonstrated in some studies to be able to differentiate between new and chronic venous thrombosis. Ventilation/perfusion scans (V/Q scans) are used for diagnosis of PE in patients with renal insufficiency in whom intravenous (IV) contrast may be deleterious. Some providers also use V/Q scans for diagnosis of PE in pregnant women, although it is associated with a higher fetal radiation dose than CTA with abdominal shielding. Options for acute therapy of VTE include: Weight-adjusted unfractionated heparin (UFH) (e.g., 80 units/kg bolus and 16 – 18 units/kg/hr continuous IV infusion), Low molecular weight heparin (LMWH) such as: enoxaparin (1 mg/kg sc q12h or 1.5 mg/kg sc q24h), dalteparin (100 units/kg sc q12h or 200 units/kg q24h), tinzaparin (175 units/kg sc q24h), Fondaparinux (5 mg daily for weight 50 kg or less, 7.5 mg daily for 50-100 kg, or 10 mg daily for more than 100 kg). Apixaban (10 mg by mouth BID X 7 days and then 5 mg by mouth BID) Dabigatran 150 mg by mouth BID (must be preceded by at least 5 – 10 days of therapy with a parenteral agent (e.g., UFH, LMWH or fondaparinux) Edoxaban 60 mg by mouth once daily or 30 mg once daily (e.g., in the case of patients with creatinine clearance of 30 – 50 ml per minute or a body weight below 60 kg), (must be preceded by at least 5 – 10 days of therapy with a parenteral agent (e.g., UFH, LMWH or fondaparinux) Rivaroxaban (15 mg by mouth BID X 3 weeks followed by 20 mg once daily) UFH is preferable for patients judged to be at high risk for bleeding (completely reversible with protamine) and patients with very poor renal function (creatinine clearance < 20 ml/min). Apixaban, dabigatran, edoxaban, fondaparinux, LMWH,and rivaroxaban are preferable for most other patients, as they do not require monitoring and, therefore, facilitate outpatient therapy. In addition, LMWH and fondaparinux are associated with a much lower incidence of heparin-induced thrombocytopenia than UFH. The direct oral anticoagulants (DOAC) apixaban, dabigatran, edoxaban, and rivaroxaban have not been associated with HIT and offer the added advantage of oral administration. Apixaban, dabigatran, edoxaban, fondaparinux, and rivaroxaban should not be used in patients with a creatinine clearance less than 30 ml/min. LMWH should be used cautiously in patients with a creatinine clearance of 20 – 30 ml/min for whom the appropriate dose of enoxaparin is 1 mg/kg once daily. Dalteparin is less dependent upon renal clearance. Renally-adjusted dose recommendations have not been made. Avoid use of apixaban and rivaroxaban in patients with moderate (Child-Pugh class B) or severe (Child-Pugh class C) hepatic impairment or hepatic disease associated with coagulopathy. Avoid use of apixaban or rivaroxaban with strong inhibitors or inducers of p-glycoprotein or CYP 3A4. Avoid use of dabigatran or edoxaban with strong inhibitors or inducers of p-glycoprotein. Patients with significant liver disease (AST or ALT > 2X ULN or total bilirubin > 1.5 X ULN were excluded from participation in all the DOAC clinical trials. Two randomized placebo-controlled trials of aspirin (100 mg once daily) in the long term treatment of idiopathic VTE after an initial course of conventional anticoagulation demonstrated that aspirin reduced the relative risk of recurrent VTE by 32% (13.8% vs. 19.1%, HR = 0.68, 95% CI 0.51 – 0.90). The risk of major and clinically-relevant non-major bleeding was not significantly increased (2.9% vs. 2.0%, HR = 1.47, 95% CI 0.70 – 3.08) However, it should be noted the risk of recurrence with aspirin in these studies is much higher than in recent extended duration treatment studies with DOACs. In the AMPLIFY-EXT study, apixaban 2.5 mg and apixaban 5 mg twice daily reduced the relative risk of recurrent VTE by 80% compared with placebo. Major and clinically significant non-major bleeding was 2.7% in placebo recipients and 3.2% in apixaban 2.5 mg BID treated patients (RR = 1.20, 95% CI: 0.69 – 2.10). Dabigatran 150 mg BID significantly reduced the risk of recurrent VTE or unexplained death compared to placebo (0.4% vs. 5.6%, HR = 0.08, 95% CI 0.02 – 0.25). Major or clinically relevant non-major bleeding was 3 fold higher with dabigatran (5.3% vs. 1.8%, HR = 2.92, 95% CI: 1.52 – 5.60). Rivaroxaban 20 mg daily was associated with an 82% relative risk reduction of recurrent VTE compared with placebo (1.3% vs. 7.1%, HR = 0.18, 95% CI: 0.09 – 0.39). Major or clinically relevant non-major bleeding was 5 fold more common than placebo (6.0% vs. 1.2%, HR = 5.19, 95% CI: 2.3 – 11.7). These trials indicate that DOACs, particularly apixaban 2.5 mg BID, are attractive alternatives to aspirin and warfarin for long-term treatment of VTE. Warfarin is started at a dose predicted to be the patient’s maintenance dose (2.5 – 7.5 mg for most patients). Loading doses should be avoided. The duration of therapy is dictated by the setting of the VTE – unprovoked = long-term therapy, triggered VTE = limited duration therapy (see Table V, Table VI, Table VII, Table VIII, and Table IX). Table V.n Therapeutic options for initial treatment of VTE Table VI.n The Johns Hopkins Anticoagulation Management Service Approach to Warfarin Dose Adjustment (Designed by Peggy Kraus, PharmD CACP) Table VII.n Warfarin management guideline Table VIII.n Guidelines for management of excessive anticoagulation with warfarin Table IX.n Duration of Therapy for Venous thromboembolism Catheter-directed thrombolytic therapy (CDT) with fibrinolytic agents such as alteplase or reteplase results in more rapid and complete clot lysis than conventional anticoagulation with 2 to 3-fold more bleeding complications. CDT appears to preserve vein valve function better than anticoagulation and reduce the incidence of post-thrombotic syndrome. CDT should be considered in any patient with extensive, acute, proximal DVT who is at low risk for bleeding complications. CDT is especially important in patients with iliofemoral DVT who have May-Thurner (iliac vein compression) syndrome. Clot lysis and venous stenting are essential to prevent recurrent thrombosis that results from venous compression. Clot lysis may also be considered in patients with suspected thoracic outlet syndrome associated with acute axillary-subclavian vein thrombosis. However, definitive surgical correction of the anatomic abnormality that leads to vessel compression is necessary to prevent recurrence. Use of venous stents alone in this disorder has been associated with an unacceptably high rate of recurrent thrombosis. Catheter-directed thrombolysis has also been applied to the treatment of mesenteric vein and cerebral venous thrombosis in appropriate candidates. Although systemic thrombolysis is no longer used for treatment of DVT, it is still useful in the treatment of patients with massive pulmonary embolism. The standard regimen is alteplase 100 mg administered over 2 hours. UFH is restarted without a bolus once the aPTT has declined below the upper limit of the therapeutic range after the completion of the alteplase infusion. Preliminary studies indicate that low-dose rtPA (0.6 mg/kg, maximum 50 mg over 2 hours) is similar to standard-dose rtPA in terms of recurrent PE and mortality but associated with a lower risk of major bleeding. Further investigation is necessary before adopting lower-dose rtPA as the standard regimen of systemic thrombolysis for PE. In light of the results of the PEITHO study, systemic thrombolysis should not be routinely used for patients with sub-massive PE. Catheter-based mechanical thrombectomy devices should be considered as an adjunctive measure to reduce clot burden and shorten the duration of thrombolysis in any patient considered for CDT therapy for DVT. Mechanical or surgical thrombectomies are also useful for treatment of massive pulmonary embolism in the event of failure of clot lysis to achieve appropriate clot burden reduction or in patients who are not candidates for thrombolysis. The ultrasound-assisted thrombolysis catheter (EKOS catheter) appears to be an effective device for rapid dissolution of massive pulmonary embolism that may represent a useful and possibly safer alternative to systemic thrombolysis for high-risk PE patients. Vena cava filters should be reserved for patients who are not candidates for anticoagulation since filters increase the relative risk of recurrent DVT by 50% and are not associated with reduced mortality. Retrievable vena cava filters should be used preferentially because they can be removed if contraindications to anticoagulation resolve. Catheter-directed thrombolysis should be considered in any patient with extensive DVT, as it results in more complete and rapid clot lysis and may reduce the incidence of post-thrombotic syndrome. Catheter-directed thrombolysis and stenting are essential to the treatment of May-Thurner (iliac vein compression) syndrome. Failure to relieve venous compression with lysis and stenting will place the patient at high risk for recurrent thrombosis. Referral to a vascular surgeon is important for patients with thoracic outlet syndrome, as surgical removal of the anatomic abnormality (cervical rib, scalene muscle venous compression) is thought to be important to prevent recurrent axillosubclavian vein thrombosis. Until recently, knee-high graduated compression stockings (GCS, 30 – 40 mmHg) were recommended to patients with DVT to reduce the incidence of post-thrombotic syndrome (PTS). However, the SOX trial, the first randomized placebo controlled trial of GCS for prevention of PTS, found a similar incidence of PTS in patients with active and placebo GCS (14.2% versus 12.7%, p = 0.58) after 24 months follow-up. However, some investigators have pointed out that adherence to stocking therapy was suboptimal (86% and 55% reported wearing their stockings 3 or more days per week at 1 month and 24 months follow up, respectively). Nevertheless, GCS are no longer recommended for prevention of PTS. Since sub-therapeutic anticoagulation has been strongly associated with PTS (OR 2.7), PTS prevention efforts should focus on optimizing anticoagulation. In patients with a permanent vena cava filter, anticoagulation should be employed if possible since filters are associated with a 1.5-fold increase in the incidence of DVT and a 13% cumulative incidence of inferior vena cava thrombosis at 8 years. Since 38% of the filter group in the PREPIC study were treated with anticoagulation, it is reasonable to assume the cumulative incidence of IVC thrombosis would have been closer to 20% if no patients continued anticoagulation. Filter retrieval is also an option since new techniques for retrieval of permanent filters have been developed. The risk of recurrent VTE is dictated principally by the presence or absence of risk factors for thrombosis. Patients with unprovoked VTE are generally considered to be at ongoing risk for recurrent VTE once anticoagulation is discontinued. Long-term therapy is also appropriate for patients with active cancer, cancer patients under treatment, or within six months of active disease or treatment. The risk of recurrence in a patient with unprovoked VTE is approximately 30-50% at 10 years after discontinuation of anticoagulation. A recent meta-analysis of randomized controlled trials and observational studies of patients with VTE found that patients with idiopathic VTE had an annual incidence of recurrent VTE of 7.4% per year. In contrast, the risk of recurrent VTE was only 0.7% per year in patients with surgical triggers and 4.2% per year with non-surgical triggers. Because the risk of major bleeding in participants of randomized controlled trials of anticoagulation was only 1 – 2% per year and major bleeding and recurrent thrombosis are associated with a similar case fatality rate (11.3% during the first 3 months of therapy), continued anticoagulation is associated with net medical benefit in most patients with an idiopathic VTE as well as those with non-surgical triggers which are still present. In contrast, one study of hospitalized patients who met one, two or more exclusion criteria for randomized controlled trials of anticoagulation had a 3-fold, 4-fold and 15-fold higher risk of major bleeding compared with clinical trial participants. Therefore, the risks of bleeding and thrombosis should be considered when deciding upon long-term anticoagulation in patients with VTE. Clinical tools to estimate the risk of major bleeding on anticoagulation include the HASBLED score and the tool developed by Clive Kearon for the ACCP Guideline (Table XII and Table XIII). Unfortunately, studies of bleeding risk assessment tools have found them to be poorly predictive of major and clinically relevant bleeding in patients with VTE. Therefore, it is premature to use them for clinical decision-making. Table XII.n HASBLED Bleeding Risk Assessment Model Table XIII.n Kearon ACCP Bleeding Risk Factors Model The risk of recurrent VTE in patients with unprovoked VTE can be estimated using the Ottawa (Men Continue and HER DOO2) and Vienna risk prediction models. The advantage of the Ottawa model is that it uses a D dimer measured during therapy so anticoagulation does not need to be discontinued to estimate the risk of recurrence. The disadvantage of the Ottawa model is that it can only be used for women as a low risk group of men was not identified. In addition, it has not been validated in a separate patient population although a validation study has recently been completed. The Vienna model can be used to estimate recurrence risk in men and women. Its shortcoming is that the D dimer value for the model is measured 3 weeks after discontinuation of anticoagulation potentially exposing patients to risk of recurrence. When counseling patients and their family about the risk of recurrence it is important to emphasize that recurrent events are rare during initial therapy. The risk of a fatal PE is 0.4% during initial therapy for DVT and 1.5% during initial therapy for PE. However, the risk of recurrence is substantial if anticoagulation is not employed for acute VTE. The risk of recurrence is 40% during the first month after a thrombotic event and 10% during months 2 and 3 post-thrombosis. Therefore, a vena cava filter should be placed in the event that a patient cannot be treated for acute, proximal, lower extremity DVT. After discontinuation of anticoagulation, if a patient suffers a recurrent thrombotic event it tends to mirror the original thrombotic event. DVT patients who suffer a recurrence develop a DVT 80% of the time while PE patients tend to have a recurrent PE 80% of the time. Post-thrombotic syndrome occurs in as many as 50% of patients within 2 years of DVT diagnosis. The risk of PTS is increased (OR 2.7) by sub-therapeutic anticoagulation. Therefore, it is essential to optimize anticoagulation during acute treatment of DVT. Catheter-directed thrombolysis also appears to reduce the relative risk of PTS by 25% compared to anticoagulation alone for proximal iliofemoral DVT. In contrast, GCS do not appear to be effective in PTS prevention. DOACs may result in a lower risk of PTS than warfarin since they are not subject to dietary interactions and have many fewer drug-drug interactions. Patient with venous thromboembolism undergoing surgery How should you manage a patient with a previous history of VTE who is undergoing surgery? Patients with a previous history of VTE undergoing surgery should be considered for extended duration DVT prophylaxis (up to 1 month for major surgery and 10-14 days for ambulatory surgery) in order to prevent recurrent VTE. (expert opinion) Pregnant patient with history of venous thromboembolism How should you manage a woman with a history of VTE who is now pregnant? Women with a previous history of unprovoked, pregnancy-associated or hormone-associated VTE should receive antepartum and postpartum anticoagulant (prophylactic [e.g., enoxaparin 40 mg daily] or intermediate dose [enoxaparin 40 mg q12h]) prophylaxis to prevent recurrent VTE. Women with a history of surgery or trauma-associated VTE should have antepartum surveillance and post-partum thromboprophylaxis (prophylactic or intermediate dose). Post-partum prophylaxis should be continued for at least 6 weeks postpartum. Patients who develop VTE during pregnancy should be treated with therapeutic dose LMWH adjusted to body weight for the duration of the pregnancy and post-partum period. It remains unclear whether LMWH should be adjusted by anti-Xa LMWH levels. Some obstetricians prefer to switch to subcutaneous UFH (250 units/kg q12h adjusted by anti-Xa levels or aPTT 4 hours after the dose) at 36 weeks of pregnancy and induce labor to improve the predictability of anticoagulation in the peripartum period. UFH has the advantage of 100% protamine reversibility compared with 60-80% reversibility for LMWH. Subcutaneous UFH/LMWH heparin should be discontinued 48 hours prior to planned delivery to ensure its clearance from the plasma. Otherwise, protamine may be necessary for reversal. Anti-Xa levels or aPTT should be used to investigate the residual presence of heparin in the mother prior to delivery. Epidural analgesia should be avoided in the presence of residual heparin. Postpartum prophylactic dose LMWH may be started 12 – 24 hours post-delivery once hemostasis is assured. Therapeutic dose LMWH should not be started until 48 – 72 hours post-delivery. Transition to therapeutic warfarin can be initiated simultaneously. Warfarin can be used safely during breastfeeding. Contraception and venous thromboembolism What can be used for contraception in women with a history of VTE? Hormonal therapy should be avoided, if possible, in women with a history of VTE. The safest options for contraception are a copper wire intrauterine device (IUD) and barrier methods, although the former is preferred due to its superior efficacy. If hormonal therapy is necessary, the Mirena® (low-dose progestin) IUD is preferred because it has not been associated with an increased risk of VTE. In contrast, depot medroxyprogesterone acetate has been recently identified as being associated with an increased risk of VTE, albeit less than estrogen-containing oral contraceptives. Travel-associated venous thromboembolism How should patients with a history of travel-associated VTE be managed on future travel for 4 hours or longer? Patients with a history of travel-associated VTE should receive travel prophylaxis to reduce the risk of recurrent VTE. Enoxaparin 1 mg/kg injected prior to the flight and knee-high graduated compression stockings (20 – 30 mmHg) have both been demonstrated to provide travel-associated prophylaxis. Aspirin has not been shown to be effective. I favor anticoagulant prophylaxis. Recurrent venous thromboembolism What conditions should be considered in patients with recurrent VTE? Important conditions to consider for recurrent VTE, despite therapeutic anticoagulation, include cancer (Trousseau’s syndrome), heparin- induced thrombocytopenia, antiphospholipid syndrome, and anatomic abnormalities contributing to extreme stasis (see Table X). Table X.n Management of recurrent VTE Venous thromboembolism can result from derangements in vessel wall integrity, hypercoagulability of the blood, or disruptions in blood flow that result in stasis. These three components have been termed “Virchow’s Triad” in honor of Rudolf Virchow, the 19th century German pathologist who made many seminal contributions to the understanding of the pathophysiology of VTE. Vessel walls are lined with non-thrombogenic endothelial cells that are devoid of tissue factor and express several anti-thrombotic proteins (including tissue factor pathway inhibitor, thrombomodulin, tissue plasminogen activator, and prostacyclin). Disruption of the endothelium exposes subendothelial tissue factor that can trigger activation of the extrinsic arm of the coagulation cascade and collagen that promotes the adherence of von Willebrand factor and platelets. Hypercoagulability of the blood underlies the excess risk of thrombosis experienced by patients who have inherited factor V Leiden, the prothrombin gene mutation, and the antithrombotic protein deficiency states of antithrombin, protein C, and protein S. Stasis contributes to VTE risk by allowing activated forms of coagulation factors to accumulate and reach a concentration sufficient to promote blood clot formation. Most episodes of VTE involve disturbances in one or more components of “Virchow’s Triad”. Post-thrombotic syndrome results from venous hypertension that occurs as a consequence of obstructed blood flow due to residual thrombus, as well as damaged venous valves. Inflammation of vessel walls and venous valves also contributes to the pathogenesis of PTS. What other clinical manifestations may help me to diagnose thrombosis/embolism? Deep venous thrombosis can present with extremity pain, swelling, heaviness, and erythema. The pain is often described as being similar to a muscle cramp that does not resolve. Prominent venous collaterals on the extremity, chest, or abdomen can be seen in patients with chronic vascular occlusion/stenosis. Pulmonary embolism can present with pleuritic chest or back pain, dyspnea, progressive dyspnea with exertion, fatigue, syncope, or sudden death. Acute mesenteric venous thrombosis can present with severe abdominal pain and signs of peritonitis, nausea and vomiting. Subacute thrombosis presents with intermittent attacks of severe abdominal pain. Patients with chronic mesenteric thrombosis can present with a vague history of abdominal pain, abdominal swelling and signs/symptoms of portal hypertension (i.e., esophageal varices), and cavernous transformation of the portal vein. Hepatic vein thrombosis presents with acute abdominal pain and swelling with signs of ascites on physical exam. May-Thurner syndrome (iliac vein compression syndrome) presents with signs and symptoms of proximal left leg DVT with evidence of involvement of the iliac vein on imaging. Early diagnosis of this entity is essential to ensure prompt and complete clot lysis and stenting of the vascular stricture. IVC thrombosis is commonly associated with the presence of IVC filters, vascular webs in the IVC and renal tumors with renal vein and IVC involvement. The clinical consequence is often bilateral lower extremity swelling, as well as swelling of the lower abdomen and pelvic/groin structures. “Doughy” body wall edema may occur up to the level of the umbilicus or higher. Chronic occlusion of the IVC results in the appearance of venous collaterals in the flanks in the abdominal wall, in addition to swelling below the level of the occlusion. Thoracic outlet syndrome should be suspected when a patient presents with unexplained proximal upper extremity DVT (i.e., absence of a central venous catheter or known local tumor or nodal vascular compression). On exam, some patients will develop paresthesias or reductions of arterial pulse strength with extremity elevation. Duplex studies of the venous and arterial circulation with the arm at baseline and in stress positions are diagnostic. Prompt clot lysis and surgical correction are necessary to prevent recurrent thrombosis. Cerebral venous sinus thrombosis presents with sudden onset of severe persistent headaches, mental status changes (confusion, lowered level of consciousness), nausea and vomiting, and visual changes (including blindness). Prompt evaluation by CT or MRI, anticoagulation with or without thrombolysis, and neuro-opthalmological exam are important for optimal outcome. In patients with unprovoked VTE, D-dimer studies can be used in conjunction with the Ottawa (Men Continue and HER DOO2) and Vienna Clinical Prediction rules to determine the risk of recurrent VTE after discontinuation of anticoagulation. Yusuf, HR, Tsai, J, Atrash, HK. “Venous thromboembolism in adult hospitalizations – United States, 2007 – 2009”. MMWR. vol. 61. 2012. pp. 401-404. (The most recent data on the healthcare burden of VTE in the United States.) Kearon, C, Akl, EA, Ornelas, J. “Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report”. Chest. vol. 149. 2016 Feb. pp. 315-52. (The 10th ACCP Guideline on management of venous thromboembolism.) Iorio, A, Kearon, C, Filippucci, E. “Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review”. Arch Intern Med. vol. 170. 2010. pp. 1710-1716. (An excellent comprehensive systematic review of the risk of recurrent VTE associated with idiopathic non-surgical and surgical-triggered episodes of VTE.) Rodger, MA, Kahn, SR, Wells, PS. “Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy”. CMAJ. vol. 179. 2008. pp. 417-426. (The original clinical study used to develop the Ottawa Risk Assessment Model for quantifying the risk of recurrent VTE in patients with idiopathic VTE.) Eichinger, S, Heinze, G, Jandeck, LM, Kyrle, PA. “Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model”. Circulation. vol. 121. 2010. pp. 1630-1636. (The original study that developed the Vienna Risk Model for patients with idiopathic VTE.) Enden, T, Haig, Y, Kløw, NE. “Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial”. Lancet. vol. 379. 2012. pp. 31-38. (The first randomized controlled trial of catheter-directed thrombolysis in the treatment of iliofemoral DVT. It demonstrated that DCT was associated with a reduction in post-thrombotic syndrome.) Meyer, G, Vicaut, E, Danays, T. “Fibrinolysis for patients with intermediate-risk pulmonary embolism”. N Engl J Med. vol. 370. 2014. pp. 1402-1411. (The PEITHO study demonstrated that tenecteplase plus anticoagulation was not associated with a reduction in all cause mortality but was associated with an increase in stroke compared with placebo plus anticoagulation.) Carrier, M, Lazo-Langner, A, Shivakumar, S, Tagalakis, V, Zarychanski, R, Solymoss, S, Routhier, N, Douketis, J, Danovitch, K, Lee, AY, Le Gal, G, Wells, PS, Corsi, DJ, Ramsay, T, Coyle, D, Chagnon, I, Kassam, Z, Tao, H, Rodger, MA. “SOME Investigators. Screening for Occult Cancer in Unprovoked Venous Thromboembolism”. N Engl J Med. vol. 373. 2015 Aug 20. pp. 697-1932.. (The SOME trial demonstrated that routine screening CT of the abdomen and pelvis was not associated with clinically meaningful benefits in patients with unprovoked VTE.) Decousus, H, Prandoni, P, Mismetti, P. “Fondaparinux for the treatment of superficial-vein thrombosis in the legs”. N Engl J Med. vol. 363. 2010. pp. 1222-1232. (This large double-blind randomized controlled trial demonstrated that low dose fondaparinux was superior to placebo for treatment of superficial venous thrombophlebitis establishing anticoagulation as the preferred approach to therapy.) Agnelli, G, Buller, HR, Cohen, A. “Oral apixaban for the treatment of acute venous thromboembolism”. N Engl J Med. vol. 369. 2013. pp. 799-808. (This double-blind randomized controlled trial demonstrated that apixaban was as effective as enoxaparin/warfarin in the treatment of acute VTE. It establishes apixaban as single-drug option for acute VTE without the need for parenteral therapy.) Agnelli, G, Buller, HR, Cohen, A. “Apixaban for extended treatment of venous thromboembolism”. N Engl J Med. vol. 368. 2013. pp. 699-708. (This double-blind RCT demonstrated that Apixaban 2.5 mg BID and 5 mg BID were more effective than placebo in the extended treatment of VTE. Apixaban 2.5 mg BID was as safe as placebo in the study.) Bauersachs, R, Berkowitz, SD, Brenner, B. “Oral rivaroxaban for symptomatic venous thromboembolism”. N Engl J Med. vol. 363. 2010. pp. 2499-2510. (This open-label randomized controlled trial demonstrated that oral rivaroxaban was equivalent to enoxaparin/warfarin in the treatment of acute VTE. The extended treatment portion of the study demonstrated that rivaroxaban was superior to placebo in the long term treatment of VTE. These data demonstrate that rivaroxaban is a one drug strategy for acute and long term treatment of VTE.) Schulman, S, Kearon, C, Kakkar, AK. “Dabigatran versus warfarin in the treatment of acute venous thromboembolism”. N Engl J Med. vol. 361. 2009. pp. 2342-2352. (Schulman and colleagues demonstrated that dabigatran was as effective as warfarin in the treatment of acute VTE. In contrast to the apixaban and rivaroxaban studies, all patients in the dabigatran study received parenteral treatment for 5-10 days prior to oral therapy.) Schulman, S, Kearon, C, Kakkar, AK. “Extended use of dabigatran, warfarin, or placebo in venous thromboembolism”. N Engl J Med. vol. 368. 2013. pp. 709-718. (In two double-blind randomized clinical trials, dabigatran was compared to warfarin and placebo for extended therapy of VTE. Dabigatran was as effective as warfarin but associated with a lower risk of bleeding. Dabigatran was more effective than placebo for prevention of VTE but associated with 3 fold more bleeding complications.) Simes, J, Becattini, C, Agnelli, G. “Aspirin for the Prevention of Recurrent Venous Thromboembolism: The INSPIRE Collaboration”. Circulation. vol. 130. 2014. pp. 1062-1071. (This meta-analysis of two recent large randomized clinical trials of aspirin for long term treatment of idiopathic VTE demonstrated that aspirin reduces the relative risk of recurrent VTE by 32% without increasing the risk of major bleeding.) Büller, HR, Décousus, H. “Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism”. N Engl J Med. vol. 369. 2013. pp. 1406-1415. (In this large double-blind randomized controlled trial, edoxaban was demonstrated to be as effective as warfarin in the treatment of VTE. Similar to dabigatran, all patients on the study received at least 5-10 days of initial parenteral anticoagulation.) Kahn, SR, Shapiro, S, Wells, PS. “Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial”. Lancet. vol. 383. 2014. pp. 880-888. (This innovative practice-changing double-blind randomized clinical trial refuted the long held belief that graduated compression stockings reduce the incidence of post-thrombotic syndrome.) Holbrook, A, Schulman, S, Witt, DM. “Evidence-Based Management of Anticoagulant Therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines”. Chest. vol. 141. 2012. pp. e152S-e184S. (The latest version of the American College of Chest Physicians evidence-based guidelines on the management of vitamin K antagonist therapy.) Bates, SM, Greer, IA, Middeldorp, S, Veenstra, DL, Prabulos, AM, Vandvik, PO. “American College of Chest Physician. Venous thromboembolism, antithrombotic therapy and pregnancy. Antithrombotic therapy and prevention of thrombosis, 9th edition. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines”. Chest.. vol. 141. 2012. pp. e691S-736S.. (The most recent ACCP guideline on VTE during pregnancy and its management.) Close more info about Thrombosis/embolism	cc/2020-05/en_middle_0111.json.gz/line2670
__label__wiki	0.676575	0.676575	Bus lane trial for taxis on BRT routes from next week Date published: 16 February 2017 Transport initiatives Belfast Rapid Transit - Glider Class A taxis will be allowed to use the bus lanes on the Belfast Rapid Transit (BRT) routes on a trial basis from Monday 20 February. The trial will apply to the bus lanes on the East and West Belfast Rapid Transit (BRT) routes and the 12 hour bus lanes in the city centre, which link the two routes. The trial will last for 12 weeks. The Department for Infrastructure’s aim is to balance and respect the needs of all road users. The Department will assess the impact of the taxis on the operation of the bus lanes during the trial period. This will include the safety of bus lane users, as well as the impact on journey times, vehicle speeds and volumes. The Department will also invite stakeholders to provide their views before reaching a decision on the long term access arrangements for taxis in bus lanes. 1. The trial relates to Class A taxis and any of the remaining taxis still licensed as Private Hire (operating under green plates) and Public Hire outside Belfast (operating under white plates). 2. Both Class B and Class D taxis are already permitted to use all bus lanes.Class B taxis are wheelchair accessible taxis and are mostly former Belfast Public Hire taxis but can include wheelchair accessible taxis which were formerly licensed as private hire. Class D taxis are locally known as Taxi Bus services. 3. Class C taxis (intended for specialist services e.g. weddings and funerals) have not been permitted access. 4. Further information on taxi classes can be found on NIDirect’s website at https://www.nidirect.gov.uk/articles/taxis-and-their-services 5. BRT East follows a route along the Upper Newtownards Road, Albertbridge Road and East Bridge Street, and the trial will include the Woodstock Link. BRT West includes Andersonstown Road, Falls Road and Divis Street, and the Stewartstown Road which will become operational during the trial. 6. The trial will apply to any of the city centre 12 hour bus lanes (which are marked on the adjacent bus lane sign with ‘7am to 7pm’), and includes the following: College Avenue College Square East Cromac Street Donegall Square East Donegall Square North Donegall Square South Fisherwick Place Great Victoria Street Howard Street May Street Upper Queen Street Victoria Street Wellington Place 7. Further information on BRT can be found on the Department’s website at www.infrastructure-ni.gov.uk/topics/transport-initiatives/belfast-rapid-transit . 8. All media queries should be directed to the Department for Infrastructure Press Office on 028 9054 0007 or e-mail: press.office@infrastructure-ni.gov.uk. Out of hours please contact the duty press officer via pager number 07623 974 383 and your call will be returned. £138,000 road improvement scheme at Clifton Park Avenue, Belfast 20 January 2020 Mallon announces the start of £215,000 resurfacing scheme on Shean Road, Forkhill 17 January 2020 Publication of Travel to and from School by Pupils in Northern Ireland 2018/2019 16 January 2020 New traffic signals scheme on the A2 Belfast to Bangor Road to commence 16 January 2020	cc/2020-05/en_middle_0111.json.gz/line2671
__label__wiki	0.779908	0.779908	Don Lemon Praises Fox News Hosts For Criticizing Trump And Barr Dimitrios KambourisGetty Images CNN’s Don Lemon praised two Fox News hosts for criticizing President Donald Trump and Attorney General William Barr on Friday, Mediaite reports. Lemon commended host Chris Wallace, and legal analyst Andrew Napolitano. Lemon said that Wallace “plays it straight on his show,” and praised Napolitano, while condemning the conservative network for pandering to conservatives and Trump supporters. He divided Fox News employees into two categories — entertainers and journalists — suggesting that Wallace and Napolitano belong in the latter, while those who say what their viewership wants to hear belong in the first category. “They have entertainers over there who get on the air and spout what they think their base wants to hear. They also have a couple real journalists over there and a lawyer who can call it straight.” It is somewhat surprising that Lemon, one of CNN’s most familiar faces, is complimenting the most popular conservative network’s employees, but given that both Wallace and Napolitano have recently broken out of the Fox News mold, criticizing both the president and members of his administration, his praise is perhaps not as unusual as it may seem at a glance. As The Hill reported, on Friday, Wallace discussed Barr’s controversial interview with Bill Hemmer, echoing a Democratic talking point and suggesting that the attorney general is “advocating” Trump’s “point of view.” Wallace reminded the viewers that Trump has long complained about not having a loyal attorney general, at least according to Special Counsel Robert Mueller’s report, opining that he appears to have finally found one in William Barr. “The attorney general seemed almost to be acting as the counselor for the defense, the counselor for the president, rather than the attorney general, talking about his motives, his emotions,” the host said. Fox News’ Chris Wallace says Trump has a new fixer and it's Bill Barr: He "clearly is protecting" Trump https://t.co/FemkYaWwNo — The Daily Beast (@thedailybeast) May 17, 2019 As detailed by a previous Inquisitr report, Barr’s statements were widely condemned, since the attorney general appeared to echo Trump, suggesting that the president’s 2016 campaign had been unlawfully spied on. In agreement with Trump, Barr also said that the origins of Robert Mueller’s Russia inquiry need to be investigated. Legal analyst Andrew Napolitano did not take aim at Barr, choosing to focus on Trump instead. As Newsweek reported, Napolitano accused the president of violating the supreme law of the country; according to the judge, Trump violated the Constitution’s separation of powers three time during the past week alone. Fox News legal analyst Andrew Napolitano says Trump has violated the separation of powers three times in the last week alone. Napolitano says Trump has been "abandoning separation of powers Madison so carefully crafted," calls it a "very dangerous trend." https://t.co/GHv5HinkMA pic.twitter.com/90xoQEOWi4 — Kyle Griffin (@kylegriffin1) May 17, 2019 This was not the first time for Napolitano to rip into the president. Trump has taken notice of the criticism, slamming the legal analyst in late April. According to Slate, Trump claims that Napolitano became “very hostile” in retaliation for not being nominated to the Supreme Court.	cc/2020-05/en_middle_0111.json.gz/line2672
__label__wiki	0.923217	0.923217	Prestigious Catholic theology award to be presented to Mary McAleese Award recognises ground-breaking 2018 doctoral thesis on children and canon law Thu, Aug 22, 2019, 19:20 Patsy McGarry Former president Mary McAleese will take part in a public conversation with renowned American Benedictine nun Sr Joan Chittister at Trinity College Dublin in November. File photograph: Naoise Culhane Former president Mary McAleese is to be presented with one of the most prestigious prizes in the Catholic world for her 500,000-word doctoral thesis on ‘Children’s Rights and Obligations in Canon Law’, completed last year. She will be presented with the Alfons Auer Ethics Award 2019 at the University of Tubingen in Germany next October. Valued at €25,000 and first presented in 2015, it is seen as Europe’s most prestigious prize for leading Catholics. Presented every two years it is named after the late Rev Prof Alfons Auer, formerly of the Catholic Theology Faculty at Tubingen, who died in 2005. One of the most influential liberal Catholic moral theologians following the Second Vatican Council, his contemporaries at Tubingen at one time included Pope Benedict and Prof Hans Kung. The commendation honouring Mrs McAleese at the University on October 30th next will be by Dr Hille Haker, Professor of Theological Ethics at Loyola University, Chicago. Currently Prof of Children, Religion and Law at the University of Glasgow, Mrs McAleese publicly defended her doctoral thesis, on which she had worked for four years, at the Gregorian University in Rome last September. She did so in Italian, for about 90 minutes, before a three-man panel of priest academics. The audience included Archbishop of Dublin Diarmuid Martin, Rector of the Irish College in Rome Msgr Ciarán O’Carroll, and the Irish Ambassador to Italy Colm Ó Floinn. Her thesis is due to be published in book form by Brill, the international human rights law publishers, next November. It is described as the first study of its kind “which subjects to comprehensive scrutiny the Roman Catholic Church’s 1983 Code of Canon law as it applies to children”. It also deals with “the 1989 United Nations Convention on the Rights of the Child to which the Holy See is State Party” and how this is adhered to by Rome. The publisher notes how Mrs McAleese’s analysis “charts a distinct and worrying sea-change in the attitude of the Holy See to its obligations under the (UN) Convention since the clerical sex abuse scandals became a subject of discussion at the Committee on the Rights of the Child, which monitors implementation of the Convention”. To mark Mrs McAleese’s receipt of the award a public conversation between the former president and renowned American Benedictine nun Sr Joan Chittister will take place in Trinity College, Dublin at 2pm on Saturday, November 2nd. Sr Chittister (83) is a theologian, author and has been a passionate advocate for women’s rights for over 50 years. Last month she was “disinvited” from speaking at a Catholic education conference in Melbourne, Australia, apparently because of her liberal views. The public conversation at Trinity is being organised by the We Are Church Ireland group, Voices of Faith, the international organisation set up to promote the leadership of women in the Catholic Church, and Trinity’s School of Religion. Alfons Auer Ciaran O Carroll Colm O Floinn Dr Hille Martin Diarmuid Mary Mcaleese Mrs Mcaleese Committee On The Rights University Of Tubingen Vatican Council Melbourne (AU) Daft.ie ads saying ‘rent allowance not accepted’ breached law, body finds Lay people should be involved in decisions on priest shortages, says ACP Young people in direct provision voice hope for ‘life without struggle’ Direct provision contributes to growth in racism, says Catholic bishop Delays in dealing with ‘high priority’ abuse cases criticised Reliance on volunteers to aid asylum seekers must end – charity Sex offender living with child in care among Tusla backlog The most common student rental scams: warning over deposits and keys Ireland loses vote in papal elections after only cardinal turns 80 South Dublin council plans affordable housing after 10-year gap Irish Times poll: Large majority want change of government Yacht captain guilty of drunk sailing had ‘God given right’ to be on Liffey More in Sponsored Church Notes Week beginning Saturday, January 18th, 2020 Week beginning Saturday, January 4th, 2020 Election 2020: Strong economy not enough for voters who want hard signs of prosperity Poll analysis: Striking similarity in support for Fianna Fáil, Fine Gael, Sinn Féin Fianna Fáil will be happy, Sinn Féin thrilled but keep an eye on the Greens 4 Over 65s are expected to ‘crawl into corner and die’, says election hopeful Valerie Cox 5 Man who killed Jastine Valdez shrugged before being shot by gardaí, inquest told Irish Times News Follow @IrishTimesNews Latest Ireland Scientist says methane from farming should be treated differently to CO2 21:03 Irish Times poll: Large majority want change of government 21:00 Nearly 2,000 more students register to vote, says USI 20:38 Councillors back plan for Magdalene laundry to be third-level college 20:23 Over 65s are expected to ‘crawl into corner and die’, says election hopeful Valerie Cox 20:09	cc/2020-05/en_middle_0111.json.gz/line2674
__label__cc	0.569342	0.430658	Kenneth J Gibson MSP MSP for the Cunninghame North Constituency Always working. FMQ on Trans Women in Female-only Prisons SNP Government Reaffirms Intention to Retain Uniform Business Rates £100 Million Investment Milestone for Building Scotland Fund SNP Government Awards Arran Development Trust £3,612,000 Fireworks Action Plan Launched Rates Relief for Retailers running Deposit Return Scheme EU citizens Vital to Scotland’s Prosperity SNP Government to Establish National Centre for Remote, Rural and Island Care No Parliamentary funds have been used for the creation and maintenance of this website. Brexit Threatens Rural Community Funding Vital funding for Scotland’s rural communities is under threat following the UK’s vote to leave the European Union (EU), the Scottish Parliament Information Centre (SPICe) has shown. Some 28% of Scottish Rural Development Programme (SRDP) funding comes directly from the EU. This equates to £364m from 2014 and 2020. SRDP funding is crucial across a range of programmes, including climate change, rural broadband and supporting agricultural and forestry businesses. Commenting, Kenneth Gibson said: “These figures show how important the EU is in supporting rural and island communities across Scotland. Without access to this vital funding, many will lose out. "Every part of Scotland voted to remain last month and it is essential our place in the EU is maintained so that our communities continue to access all the advantages it brings to Scotland. Of course, it is the UK Tory Government which has put this vital funding needlessly at risk." The SPICe Briefing is available here.	cc/2020-05/en_middle_0111.json.gz/line2680
__label__cc	0.643649	0.356351	January 22, 2020 3:23 am You are here:Home NewsTelcos look for more time to implement new call drop norms Telcos look for more time to implement new call drop norms Posted by Shantanu on September 16, 2017 Telecom companies have asked for more time to implement stricter rules aimed at preventing call drops, the regulator said. “They have not opposed it (new rules) but they have asked for more time. They want to put in some systems… We will examine their request,” said Telecom Regulatory Authority of India chairman RS Sharma. In the new rules issued on August 18, Trai set penalties of up toRs 10 lakh per circle in a quarter on operators failing to meet voice quality benchmarks. The quality of voice service will now be measured at the base station level instead of the circle level. The rules, effective October 1, are also aimed at ensuring coverage in under-served areas. They mandate telcos to pay Rs 1-5 lakh — depending on the extent of the violation — in a quarter. Violations in consecutive quarters will result in 1.5 times the penalty levied in the first quarter and twice that if they continue in the third quarter, subject to a cap of Rs 10 lakh in a three-month period. The new and stricter rules on call drops are meant to overcome a shortcoming in the earlier method of assessing a network’s performance in a service area over a month, which would mask individual cell sites that functioned poorly or not at all on some days. As a result, even though telcos met quality standards, some subscribers still complained of call drops, Trai said. Graded penalties, which will be based on new performance benchmarks at the base station level, will be levied from January 1, a quarter after the rules kick in. The three-month period to December end will be used for observations of call drop information that telcos share with the regulator, Trai said. However, carriers said the new guidelines would add to the complexity of rules. They said the regulator should not blame telcos alone as other factors, including the number of users on the network at a time, subscribers being indoors or outdoors, and issues with handsets, could be responsible for call drops. About Shantanu View all posts by Shantanu → Apple may launch 6.1-inch LCD iPhone with 18:9 screen this year UIDAI announces virtual Aadhaar ID, hopes it will solve privacy problems Facebook, Instagram accounts latest hijack victims, release on ransom Lawsuit filed against Infosys in US by former immigration head Electric vehicles are future of transportation in India: NITI Aayog CEO Amitabh Kant	cc/2020-05/en_middle_0111.json.gz/line2688
__label__cc	0.706997	0.293003	Health Coaching for Women Femergy @ 40 – at a glance Resilient Weight Loss & Lifestyle Group Programme My Coaching Programmes Why Women Matter The Real Food Solution Menopause Retreat – 17/18 March 2020 Oxford Real Farming Conference 2018 REAL FOOD CAMPAIGN Welcome to Health Coaching for Women Welcome to health coaching for women at midlife. Build resilience, create health, fix weight, feel better and live more! Click a programme to learn more Click here to find out more about my NEW Resilient Weight Loss Programme Creating a resilient, healthy midlife is life-changing. From our mid-30's onwards, we start a decades-long journey of new discoveries about who we are and how we want to live. For women, it's absolutely a time to recalibrate and step into our prime-time. It's a time to recognise, nurture and embrace our deep wisdom, share our gifts with confidence and to step forward courageously to make the rest of life, the best of life. A time to shine. I passionately believe that women-in-prime-time have never mattered more in the world today. Living with intention, building a vision and transitioning to a new stage of life with confidence and resilience has never mattered more. The desire to feel much better and to live more has never been more important for us. But at the same time, it can be challenging too. Here's what women are saying: ♥ I want to feel better, but I'm simply overwhelmed. My body keeps whispering "slow down girl", but I keep on going and going... ♥ I want to nip my niggling health issues in the bud - I'm sleeping badly, have no energy and am tired all the time. I struggle all the time with my weight and now I'm getting unexplained aches and pains, a permanently fuzzy head and I've difficulty in concentrating. I feel my body's urging me to: "Stop... please, listen". ♥ I want to lose weight intelligently and get confident about maintaining an optimum weight. I'm SO tired of dieting.... always trying new diets that work for a while. I'll lose weight, but then I lose willpower and fall off the wagon. I keep on regaining the weight I've lost... and more. It's distressing. I just want to relax and enjoy my food. I want more energy, to be happy, to feel like 'ME'. I sense my body urging me to: "Stop... stop dieting and find a long-term solution to get this weight off and keep it off." ♥ I want better health and a better quality of life. I've been struggling for too long with my health issues - an intestinal or digestive disorder, an autoimmune condition, miserable hormonal dysfunction, infertility, a thyroid problem. I'm pre or T2 diabetic, or struggle with obesity. I need answers and I need help. My body's crying out: "Help. Me. Now." Yes, women are yearning to get more from life and they are recognising their body's call to take action. But here's the rub: knowing we should do something and actually doing something about it are very different. This is where experienced, compassionate health coaching can make the difference between wishing for more from life and taking action to create a new and vibrant reality. You’re one of many women at midlife for whom health coaching can be life-changing! As women, we're hard-wired and deeply invested in wanting to save the world - to 'fix it' for everyone from our partner and family, to our planet... and, when there's time and energy, we show up for ourselves. But we're trying to do so much at once that the impact on our well-being - mind, body and spirit - is not only overwhelming, it's just not sustainable. We want to show up to be the best we can be... but our energy, motivation and our health just isn't co-operating! Why 'femergy'? Women hold the family and indeed, the whole world in the palm of our hand. Our archetypal roles of 'Queen', 'Mother', 'Wise Woman' and 'Lover' call on us to be deeply intuitive and intensely concerned with our young, our mate and our ‘pack’ - and by extension, our planet. But it’s a heavy load: Overwhelm, fatigue and the feeling we need to do more, be more and care more depletes us daily As we transition to midlife, in caring for others, our own health and happiness are suffering – and so is our ability to hold everything together. Many of us, beleaguered from puberty by less than optimum health, are left feeling that our health and our vitality is slowly ebbing away. Well it's time to reclaim it. Our food and lifestyle is our first medicine. By making delicious (no-fad) real food and powerfully simple lifestyle changes we really CAN build resilience and restore our femergy, make midlife and beyond our prime-time - and make the rest of our lives the BEST of our lives! “The food you eat can be either the safest and most powerful form of medicine or the slowest form of poison.” - Anne Wigmore, Holistic Health Practitioner I'm proud member, affiliate or an active supporter of these leading-edge bodies in functional, holistic and lifestyle medicine and in population health - leading the way to help us to understand that creating resilience and true health is about supporting the whole person in their environment. Click here to discover more about the important work of these organisations. How can nutrition & lifestyle health coaching help you? A ‘shout-out’ for Sugar? Am I going crazy?! Make simple lifestyle changes to build new habits #Organuary 2020! My Beef Shin Ragu is OFFALY Good (Recipe) Offaly Good Beef Shin Ragu – 100% grass-fed! “If you treasure your health and wellbeing… you should get in contact with Izabella ASAP!” Marina’s testimonial Sign up & receive a FREE pdf with tips on how to regain energy, vitality and health IzabellaNatrins.com © 2020. All Rights Reserved. Sign up for my periodic emails to receive interesting, relevant and informative content, news, research, advice, tips and more. As a 'Thank You' I'll send you a FREE pdf with great advice and information on reducing the toxic load of your home and other simple lifestyle changes you can make to improve your health.	cc/2020-05/en_middle_0111.json.gz/line2689
__label__cc	0.562844	0.437156	Home / Posts tagged “madness of lord byron” Tag: madness of lord byron Jane and the Madness of Lord Byron: A Review Sequels and Spinoffs austenprose, Francine Mathews, George Gordon, Jane Austen Detective, Jane Austen Mystery, Laurel Ann Nattress, Lord Byron, madness of lord byron, mystery, Stephanie Barron Jane and the Madness of Lord Byron: Being a Jane Austen Mystery By Stephanie Barron A Review by Laurel Ann Nattress One thinks of Jane Austen as a retiring spinster who writes secretly, prefers her privacy and enjoys quiet walks in the Hampshire countryside. Instead, she has applied her intuitive skills of astute observation and deductive reasoning to solve crime in Stephanie Barron’s Austen inspired mystery series. It is an ingenious paradox that would make even Gilbert and Sullivan green with envy. The perfect pairing of the unlikely with the obvious that happens occasionally in great fiction by authors clever enough to pick up on the connection and run with it. Jane and the Madness of Lord Byron marks Stephanie Barron’s tenth novel in the best-selling Jane Austen Mystery series. For fourteen years, and to much acclaim, she has channeled our Jane beyond her quiet family circle into sleuthing adventures with lords, ladies and murderers. Cleverly crafted, this historical detective series incorporates actual events from Jane Austen’s life with historical facts from her time all woven together into mysteries that of course, only our brilliant Jane can solve. It is the spring of 1813. Jane is home at Chawton Cottage “pondering the thorny question of Henry Crawford” in her new novel Mansfield Park and glowing in the recent favorable reception of Pride and Prejudice. Bad news calls her to London where her brother Henry’s wife Eliza, the Comtesse de Feuillde, is gravely ill. With her passing, Jane and Henry decide to seek the solace and restorative powers of the seaside selecting Brighton, “the most breathtaking and outrageous resort of the present age” for a holiday excursion. At a coaching Inn along the way they rescue Catherine Twining, a young society Miss found bound and gagged in the coach of George Gordon, the 6th Baron of Byron, aka Lord Byron, the notorious mad, bad and dangerous to know poet. Miffed by their thwart of her abduction, Byron regretfully surrenders his prize to Jane and Henry who return her to her father, General Twining, in Brighton. He is furious and quick to fault his fifteen year-old daughter. Jane and Henry are appalled at his temper and concerned for her welfare. Settled into a suite of rooms at the luxurious Castle Inn, Jane and Henry enjoy walks on the Promenade, fine dining on lobster patties and champagne at Donaldson’s and a trip to the local circulating library where Jane is curious to see how often the “Fashionables of Brighton” solicit the privilege of reading Pride and Prejudice! Even though Jane loathes the dissipated Prince Regent, she and Henry attend a party at his opulent home the Marine Pavilion. In the crush of the soirée, Jane again rescues Miss Twining from another seducer. Later at an Assembly dance attended by much of Brighton’s bon ton, Lord Byron reappears stalked by his spurned amour, “the mad as Bedlam” Lady Caroline Lamb. Even though the room is filled with beautiful ladies he only has eyes for Miss Twining and aggressively pursues her. The next morning, Jane and Henry are shocked to learn that the lifeless body of a young lady found in Byron’s bed was their naïve new friend Miss Catherine Twining! The facts against Byron are very incriminating. Curiously, the intemperate poet is nowhere to be found and all of Brighton ready to condemn him. ‘Henry grasped my arm and turned me firmly back along the way we had come. “Jane,” he said bracingly, “we require a revival of your formidable spirit – one I have not seen in nearly two years. You must take up the role of Divine Fury. You must penetrate this killer’s motives, and expose him to the world.”’ [page 119] And so the game is afoot and the investigation begins… It is great to have Jane Austen, Detective back on the case and in peak form. Fans of the series will be captivated by her skill at unraveling the crime, and the unindoctrinated totally charmed. The mystery was detailed and quite intriguing, swimming in red herrings and gossipy supposition. Pairing the nefarious Lord Byron with our impertinent parson’s daughter was just so delightfully “sick and wicked.” Their scenes together were the most memorable and I was pleased to see our outspoken Jane give as good as she got, and then some. Readers who enjoy a good parody and want to take this couple one step further should investigate their vampire version in Jane Bites Back. Barron continues to prove that she is an Incomparable, the most accomplished writer in the genre today rivaling Georgette Heyer in Regency history and Austen in her own backyard. Happily readers will not have to wait another four years for the next novel in the series. Bantam is publishing Jane and the Canterbury Tale next year with a firm commitment of more to follow. Huzzah! Publisher:Bantam Books (2010) Trade paperback (352) pages A life-long acolyte of Jane Austen, Laurel Ann Nattress is the editor of Austenprose.com and the forthcoming short story anthology Jane Austen Made Me Do It to be released by Ballantine Books in October, 2011. Classically trained as a landscape designer at California Polytechnic State University at San Luis Obispo, she has also worked in marketing for a Grand Opera company and at present delights in introducing neophytes to the charms of Miss Austen’s prose as a bookseller at Barnes & Noble. An expatriate of southern California, Laurel Ann lives near Seattle, Washington where it rains a lot. Enjoyed this article? Visit our giftshop and escape into the world of Jane Austen.	cc/2020-05/en_middle_0111.json.gz/line2692
__label__wiki	0.547246	0.547246	- Breast Health - Colorectal Surgery - Gynaecology - Ophthalmology - Orthopaedic Surgery - Urology - A-Z of all our specialties - Patient Satisfaction - How to Book - Paying for treatment - Self-paying patients - Private Medical Insurance - Patient Pre-Assessment - Your Stay - Our Nursing Care - Visiting a patient - International Patients The Charity - Support Us - Our Events - Our Publications - Centre for Veterans’ Health - Apply for a military grant or subsidy A-Z of all our specialties Self-paying patients Patient Pre-Assessment Our Nursing Care Centre for Veterans’ Health Apply for a military grant or subsidy Mr Gareth G Jones Mr Gareth G Jones is a Consultant Orthopaedic Surgeon and Clinical Senior Lecturer in Orthopaedics at Imperial College London - a role that enables him to combine his cutting-edge research with clinical practice. He sub-specialises in knee surgery, with the treatment of knee injuries and knee osteoarthritis the focus of both his clinical and academic work. Training Background Gareth graduated from Imperial College London in 2003, with a 1st Class Honours degree in Physiology, and a Medical Degree with distinction. He completed his specialist training at Imperial College in 2017. During this time he was also awarded a PhD for his research into the use of personalised 3D printed guides to improve the accuracy of joint preserving surgery for knee osteoarthritis. Knee Sub-specialist Fellowship Training Gareth completed two prestigious travelling fellowships. The first learning highly specialist knee replacement techniques, including same-day knee replacement surgery, with both Dr. A. Lombardi and Dr. M. Berend in the USA. The second with a number of pre-eminent members of the European Knee Society in Denmark, France, Italy and Germany. Gareth subsequently completed a one year sub-specialist knee fellowship at Guy’s and St.Thomas’ Hospitals. Joint preservation, personalisation and accuracy define Gareth’s surgical approach. He uses 3D motion-capture alongside traditional imaging to assess the way in which patients walk and inform surgical decision making. Patients undergoing surgery are routinely scanned to create a 3D computer bone model of their knee. Working closely with Embody Orthopaedic (https://www.embody-ortho.com), this bone model allows Gareth to first perform a virtual operation – planning the optimal position for saw cuts and implant size/position. Once finalised, this surgical plan is used to inform the design of personalised surgical instruments. These instruments only fit the patient they are intended for, and are used to accurately deliver the surgical plan in the operating theatre. Enquiries & Appointments Make an appointment Email an enquiry Specialties Orthopaedic Surgery Interests Knee surgery BSc(Hons), MBBS, FRCS (Trauma and Orthopaedics), PhD King Edward VII's Hospital, 5-10 Beaumont Street, Marylebone, London, W1G 6AA. enquiries@kingedwardvii.co.uk Switchboard 020 7486 4411 020 7486 4411 Bookings 020 7467 3221 020 7467 3221 HRH The Duke of Kent © 2020 King Edward VII’s Hospital All rights reserved Privacy Policy Terms & Conditions Sitemap Reg. Charity No. 208944 We accept online payments from	cc/2020-05/en_middle_0111.json.gz/line2700
__label__wiki	0.588163	0.588163	NOWCAST KSBW Action News 8 Midday KSBW Weather Loma Prieta Earthquake Central Coast Spotlight Crystal Apple Award Golden Whistle Highway 68 reopens after fatal accident near Salinas Updated: 7:00 AM PDT Mar 27, 2014 KSBW SOURCE: KSBW The California Highway Patrol reopened the westbound lanes of Highway 68 Thursday morning after a pedestrian was hit and killed by a car.The 6:10 a.m. accident happened near the Portola Road exit near Salinas. CHP Officer Jaime Rios said a 70-year old Monterey man was attempting to cross Highway 68 from the south side of the roadway when a 2009 Chrysler hit him.The Chrysler was driven by a 52-year-old Soledad woman. She was not injured.The CHP diverted traffic onto Reservation Road for two hours while they investigated a cause of the accident. Highway 68 was fully reopened at 8:45 a.m. SALINAS, Calif. — The California Highway Patrol reopened the westbound lanes of Highway 68 Thursday morning after a pedestrian was hit and killed by a car. The 6:10 a.m. accident happened near the Portola Road exit near Salinas. CHP Officer Jaime Rios said a 70-year old Monterey man was attempting to cross Highway 68 from the south side of the roadway when a 2009 Chrysler hit him. The Chrysler was driven by a 52-year-old Soledad woman. She was not injured. The CHP diverted traffic onto Reservation Road for two hours while they investigated a cause of the accident. Highway 68 was fully reopened at 8:45 a.m. KSBW Monterey ©2020, Monterey Hearst Television Inc. on behalf of KSBW-TV.	cc/2020-05/en_middle_0111.json.gz/line2703
__label__wiki	0.992348	0.992348	Showtime says ‘Shameless’ will air final season this summer This image released by Showtime shows cast members from the original series “Shameless,” from left, Steve Howey as Kevin Ball, Shanola Hampton as Veronica Fisher, Kate Miner as Tami Tamietti, Jeremy Allen White as Lip Gallagher, William H. Macy as Frank Gallagher, Emma Kenney as Debbie Gallagher, ChristianI Isaiah as Liam Gallagher, Ethan Cutkosky as Carl Gallagher, Cameron Monaghan as Ian Gallagher and Noel Fisher as Mickey Milkovich. Showtime Entertainment President Gary Levine said Monday the series will air its 11th and final season this summer. (Brian Bowen Smith/Showtime via AP) PASADENA, Calif. (AP) — The wild ride of the Gallagher family on “Shameless” is coming to an end. The series will air its 11th and final season this summer, Showtime entertainment president Gary Levine said Monday. The debut date was not immediately announced. “It will be one last hurrah for the Gallaghers and their unique blend of love and lechery,” Levine told a TV critics meeting. Producer John Wells and the cast have “promised to take ‘Shameless’ out with a bang.” William H. Macy stars as the family patriarch who gets by in life just about any way he can, setting a dubious example for his offspring and others in his orbit. The season 10 finale of “Shameless,” which also stars Jeremy Allen White, Ethan Cutkosky and Shanola Hampton, will air Jan. 26. STANFORD, Calif. (AP) — A Stanford institute is home to copies of the most significant correspondence, sermons, speeches, writings and manuscripts of Martin Luther King Jr. But the historian tasked with protecting the documents and other artifacts is anxious about what will become of them when he retires this year. Clayborne Carson, 75, was selected by Coretta Scott King in 1985 to edit and publish the papers of her late husband housed at the world-renowned Martin Luther King Jr. Research and Education Institute. MIAMI (AP) — Four Florida passengers were in for a shock when actor Will Smith answered their Lyft call and gave them a ride around town. The actor was in Miami promoting his new movie, “Bad Boys for Life,” over the weekend. He picked up four riders in a 2020 Porsche Taycan, occasionally getting into the attitude of his movie character detective Mike Lowry and encouraging passengers to do their best Bad Boys imitation as his partner in crime. MALIBU, Calif. (AP) — Pamela Anderson has married movie producer Jon Peters. Anderson and Peters married Monday in a private ceremony in Malibu, California, a representative for Anderson said Tuesday.	cc/2020-05/en_middle_0111.json.gz/line2704
__label__cc	0.515003	0.484997	Here’s the lowdown: Scaggs, Cho add to arts landscape Betsy Pickle September 5, 2019 Arts 865 "The Art of Science," featuring works by professors and students, will open at the Emporium Center on Friday. We know that Knoxville loves First Friday, but before it descends, let’s take a moment to celebrate Thursday. The underappreciated day before the start of the weekend holds something special this week: The legendary Boz Scaggs is performing tonight at the Tennessee Theatre on his “Out of the Blues” tour. Scaggs paid his dues for years before finally breaking through in 1976 with “Silk Degrees.” It was one of those albums everybody loved, whether you never listened to anything but the radio or dug deep on every 10-inch record to find the hidden gems. “Silk Degrees” had both hits and secret treasures, and its songs remain some of the best of ’70s pop R&B. Not the most prolific recording artist around, Scaggs always creates excitement when he releases new music or goes on tour. Tonight is your chance. Don’t miss it. ‘Make tonight a wonderful thing’ Speaking of acts that dominated the 1970s, the much-admired Steely Dan tribute band The Fine Colombians is playing at 8 p.m. Friday at the Open Chord, 8502 Kingston Pike. The ensemble of veteran local musicians made its debut in December 2017 and has developed a rabid fan base. Turns out locals love both Steely Dan tunes and great musicianship. Tribute to Toni Downtown Knoxville gets the most attention on First Fridays, but always keep your eyes and ears open for outlying events. Central Cinema will screen “The Pieces I Am,” a documentary about Toni Morrison, twice on Friday, with more screenings through next week. The acclaimed author of “Beloved” and “Song of Solomon” died last month at age 88. Just to demonstrate the depth of variety of Central Cinema, the theater is also opening “Satanic Panic” (2019) – about a newbie pizza delivery driver whose last stop on her first day is to a bunch of Satanists – on Friday and playing the 1995 version of “A Little Princess” on Saturday and Sunday. First Friday is good about emphasizing local talent, but this month there’s a bonus. Homegrown comedian Henry Cho is performing at 8 p.m. at the Bijou Theatre. A veteran of the big screen and the small screen, Cho is both hilarious and a great guy. Go downtown early to check out the art, and then have some laughs with Cho. Head here, there, everywhere There’s art everywhere you turn on First Friday, so how do you decide what to see? Well, the easy place to start is the Emporium Center, 100 S. Gay St. From 5-9 p.m., you can check out the fall juried show by the Tennessee Artists Association; the “Art of Science” representing works by scientists from the University of Tennessee, the University of Washington and Australia National University; “Twisted Woodturning” by Brian Horais; paintings from “An Abstract Narrative” by Victoria Phillips; and drawings and paintings by Anthony Donaldson. Music will be provided by pianist Curtis Tipton, and hors d’oeuvres will be served. A painting from Heather Finney’s “Acceptance” series Galleries, restaurants, bars – you’ll find something creative everywhere throughout downtown and the Old City. The big buzz is around the Art Slam hosted by Dogwood Arts in Strong Alley. You can watch as 17 of Knoxville’s most talented artists create works of art under a three-hour deadline, starting at 5:30 p.m. The art will be auctioned off to benefit the Art in Public Places Mural Program. Strong Alley is between Gay Street and Market Square; enter from Wall Avenue or Union Avenue. Makes Cents Jewelry will be at the Knoxville Visitors Center from 4 to 6, with proceeds from sales going to mental-health awareness (there will also be live music). Knoxville author Jack Neely will spill “The Mysteries of Union Avenue” at Union Ave Books, starting at 6. There are already two things to love at Coffee & Chocolate, and this month you can fall in love with another when you check out paintings by Heather Finney from her series “Acceptance.” The Gratitude Bar at Body Mind Realign, 111 N. Central St., will host the Knoxville debut of artist Beth Free, who works with such varied techniques as palette knife, acrylic pouring, mixed media and mosaic. Find details on these and much more here. Beth FreeBijou TheatreBoz ScaggsHeather FinneyHenry ChoJack NeelyKnoxville First FridayKnoxville Visitors CenterStrong AlleyTennessee TheatreThe Emporium CenterToni Morrison	cc/2020-05/en_middle_0111.json.gz/line2708
__label__cc	0.653682	0.346318	Liz Iaconis Liz Iaconis, News Editor Mrs. Chase Department: House 4 Guidance Counselor Getting to know her: In her free time, she plays Sims “like it’s her job,” plays other video games, and cuddles with her pug, Darla. Chase claims her pug is her obsession. Mrs. Sherwood Getting to know her: Sherwood is a mom and a dog mom to two rescue dogs, and she is really excited to get to know the students and families at the school! Mrs. Bound Department: CP Algebra 1A and 1B, CP Pre-Calculus teacher Getting to know her: Bound grew up dancing and can’t wait to see the dance team in action. She is also looking forward to becoming a member of the community, living in town. Ms. Snowdon Department: Honors Biology and Freshman Science teacher Getting to know her: Snowdon recently graduated from UNH with her master’s degree, and she is eager to learn her way around LHS and build the community through her students. Mr. Blouin Department: CP Biology A and Freshman Science teacher Getting to know him: Blouin is excited to go to Londonderry sporting events, even though he lives in Rochester, and he spends a lot of his free time with his six-month-old daughter. Mr. Astbury Department: Pre-Algebra, CP Geometry A, and CP Algebra 1&2 A&B teacher Getting to know him: Astbury graduated from local highschool, Souhegan in Amherst and is looking forward to being part of a bigger high school atmosphere. At Souhegan, he ran cross country and track and suggests to any student as a great way to achieve personal goals. Ms. Brennan Department: AP Statistics and CP Algebra 1A teacher Getting to know her: Brennan was the math teacher for the 8th grade Heatwave team at LMS but is ready for a fresh start at the high school. She is excited to see growth from her former students. Brennan is also an avid runner and training to qualify for the Boston Marathon. Department: Special Education Case Manager for the class of 2019 Getting to know her: Miller has two children, one 17 years old and the other 25, and she is also a proud owner of five dogs! Madame Johnson Department: French 1&2 teacher Getting to know her: Johnson is a new mother to a 5 week old baby girl, and she loves to knit and sew. In addition to speaking French fluently, she has also achieved a certified Spanish proficiency. Ms. Brown Department: Freshman Science Getting to know her: Brown is excited to get to know her students and the faculty and help Lancer Nation wherever she can to make this the best year! Mr. Waters Department: CP and Honors English 9 Getting to know him: Waters wants to share the joy in reading with his classes and has challenged himself to make Pride and Prejudice a fun read. As a college student he was a stand-up comedian while studying TV and video production at Hofstra University. Art interactive paints smiles on students’ faces Students in new multimedia class get behind mics, cameras to get news out Green Council hopes to paint the community green The man behind the bars: Elghazal reveals the making of the Pinkerton diss track “Astro Clown” Daley and Khalil spill the tea on their presidential duties	cc/2020-05/en_middle_0111.json.gz/line2709
__label__wiki	0.58503	0.58503	L.A. Parent #CampReady Kids & Media Moms At Work Moms Groups Inclusive L.A. Inclusive Newsletter Inclusive News Education & Learning Differences Adaptive Enrichment Add a Support Group Send Us Your Community News Mom’s Health Send Us Your School News Ready For College Teachers and Programs of Note School Open Houses Family Fun & Travel Theme Parks, Zoos & Aquariums At L.A. Museums Date With L.A. Summer Camp Guide 2020 Free Recipe Downloads Easy Family Traditions By Margot Black Writer Margot Black and her family go all out for Halloween. Over the years, they have dressed up as superheroes, ninjas and characters from the Harry Potter and Percy Jackson books. PHOTOS BY BEBE JACOBS PHOTOGRAPHY Family traditions bring the generations together and give us the chance to build lasting memories – and they don’t need to exhaust you, your family or your budget to be worthwhile. The holiday season is rapidly approaching, and with it the expectation of family celebrations stamped with the Martha Stewart seal of approval. But manifesting these wildly unrealistic presentations is no easy feat. If the thought I just can’t wait for the holidays to end so we can all go back to our lives has ever crossed your mind, know that you are not alone. What if I told you that you can build great everyday traditions that don’t have to wait for the holidays and won’t fill you with dread? It’s time to relax your expectations, log off Instagram and invent some easy, breezy traditions that will still have an impact. What are traditions? Traditions help define our families’ shared identity. In the opening number of the Broadway musical “Fiddler on the Roof,” Tevye remarks, “Because of our traditions, we’ve kept our balance for many years.” Anthropologists have yet to discover a human culture without tradition, and it’s something we intuitively strive to pass down from generation to generation. Rituals and traditions play a significant role in providing comfort, consistency and security to children, in addition to teaching them values and generating joyful memories. Yet tradition does not need to be religious, large or complex to have value. Any activity can be a family tradition – as long as the experience is infused with some joie de vivre that elevates it above commonplace routines. If you sometimes walk around the park with your kids, that’s just something you do. But if you do it every Saturday, pack a picnic and name it your “Saturdays in the Park,” or if you celebrate the end of each work week by playing Frisbee together and naming it “Frisbee Fridays,” it can become a wonderful family tradition. “Any simple ritual or tradition, such as caring for a garden together, washing cars on Saturdays, celebrating birthdays in a consistent way, gives a child a sense of security, identity and belonging and has value to the family unit,” says Beverly Hills family therapist Susan Ricker. “Children really like to know they can count on some things and thrive with a sense of security at a young age. Small traditions definitely provide comfort for kids.” The gift of simplicity The best way to incorporate traditions into modern family life is to keep them simple and set a playful tone so everyone will be more willing to participate. Even with simple traditions, you are strengthening your family’s sense of connection. Two of my family’s simplest traditions – Taco Tuesdays and Sunday Sundaes – have paid off wonderfully. Margot Black, at left, and family and friends try to gather at least monthly for Taco Tuesdays – at home or as a welcome night out. PHOTO COURTESY MARGOT BLACK Taco Tuesdays started years ago as a way to filter social time with family friends into a casual, uplifting weekly activity. Since my son is now in middle school and life gets busy, we try to make sure we have Taco Tuesday at least once a month. We might be with the same friends in the same place or with different friends in different places, but no matter what – we’re eating tacos on a Tuesday. This tradition has proven to be a superb way for our family to organize visitors, meal preparation, consistency – and sometimes a welcome midweek restaurant visit. When our son was younger, we would eat ice cream with another family down the block who eventually started introducing us to new ice creams. One day, we added sprinkles into the mix, put a cherry on top, and Sunday Sundaes was born! Since the kids were still little, Sunday Sundaes became one of the more consistent and fun ways to enjoy easy dessert. To this day, everyone still looks forward to this fun act of creativity and tradition. And if you’re coming to our house for dinner on a Sunday, you’ll be invited to join in the fun. Morty Coyle, vocalist in the local band All Day Sucker and head writer for the music-centered podcast “The 500,” has been doing weekly car karaoke with his daughter, Beatrix, for two years. They post each performance on Instagram as @beaanddaddycartunes. “The old tradition of once a year sending out a long family update note in people’s mailboxes is antiquated now with social media,” Coyle says. “With our songs, family members can see what’s going on from week to week. Beatrix has learned so much about music, harmonies and bands from doing this together. And at some point, she will have an anthology of a very specific time in her life to look back on.” Coyle and Beatrix are also continuing a musical tradition from previous generations. “My mother sings and she sang with her family. I sing, and now singing with my daughter is just an extraordinary joy,” Coyle says. “It all started because we would get to school early and have fun singing a song to each other in the car before school started. It kind of snow-balled into a quirky and personal tradition for us from there.” Sometimes, they’re free While creating and maintaining traditions may require effort, it doesn’t have to be expensive. One affordable and fulfilling tradition my family enjoys is singing to each other whenever we’re near a clock and we notice their birthday date come up (9:26 for a Sept. 26 birthday, for instance). We all take a minute to pause and sing to them. It’s that simple, and I hope my son continues to sing me birthday songs (even if it’s in his head) when he’s in college. It was my husband’s idea to start reading together as a family every night at bedtime. We’ve enjoyed every Harry Potter book, every Ranger’s Apprentice book and every Percy Jackson book, and have read through every country and every time zone, every trial, tribulation and celebration. The books we’ve been reading out loud have even influenced some of our Halloween costumes. Morty Coyle and his daughter, Beatrix, sing karaoke and post to Instagram as @beaanddaddycartunes. PHOTO COURTESY MORTY COYLE Speaking of Halloween, some traditions may require slightly more time and cash, such as my family’s delightful decree to go all out on our group Halloween costumes every year. I hope my middle-schooler isn’t too cool this year to dress up with Mom and Dad! Teen therapist Elizabeth Kromhout, MFT, suggests we’ve at least laid the groundwork. “If you don’t have a solid base of a few traditions during the teen years, it will be even harder to keep the kids included in your family activities,” she says. “They might rebel for a bit in their teens and not want to participate, but eventually they usually swing back.” When you do get the kids to participate, make sure you give them your complete attention. “A very common complaint I hear from teens in my office is that their parents won’t get off their phones,” says Kromhout. “When it’s time to be with your family and experience the traditions and time together, get off your phones and be fully present with your kids.” Personal, practical and possible When starting a new family tradition, it’s best to announce your plans beforehand so that everybody anticipates what’s coming and when. Children are big fans of routine, so they may require some time to warm up to a new tradition, and you might need to adjust some details accordingly. The most important part is that the traditions you choose are personal to you, practical to execute and that you’re somewhat consistent with them so that you feel like it’s always possible to follow through. Try generating a new weekly, monthly and yearly tradition to help you get started. You could even try something that helps your kids build a useful life habit, such as planning all the food for the week together on a Sunday, or anything that imparts life skills and values. The traditions that are really simple and filled with love are the most powerful ones, and these usually don’t make anyone feel weighed down. Choosing and sticking with these simple, everyday traditions will pay off in the long run. If the holidays or life milestones come around and you’re not up to the challenge of a big production, you won’t feel that you’re shortchanging anyone if you’ve provided your family with consistency, comfort and security through small traditions all year around. Margot Black is a storyteller with more than 15 years of experience, an L.A.-based traveler, wife and mom. Filed Under: Elementary School, Instagram, Life At Home, Tweens and Teens love this? share! Just so we know you're a real, live human being... Will Pot Legalization Boost Teens’ Use? How To Have a Great Family Portrait Session The Art of Getting the Kids Outdoors in the Los Angeles Area On the Record: Teaching Kids About Family Heritage How Pint-Size Influencers Mila & Emma Took Over Instagram Booki Vivat Turns Doodles Into Her Debut Book Current IssueThis Month Beyond L.A.Beyond L.A. Education GuideEducation Guide Inclusive L.A.Inclusive L.A. Search EventsSubmit an EventUpdate an Event Sign up to receive our newsletters! Sign up today to receive updates and information by email from L.A. Parent! Email: First Name: Last Name: Zip Code: Please choose which list(s) you would like to subscribe to below: Inclusive L.A. Monthly L.A. Parent Magazine About L.A. Parent LA Parent Log In to Submit Events Expert Contributors L.A. Parent at a Glance Copyright © 2020 Epstein Custom Media, Inc. All Rights Reserved Privacy \| Sitemap \| Contact Web Design & Development By Guido Media Summer Camp Season is Here We know it’s January, but summer camp fairs start next month and we’re sharing our news now! Our 2020 Online Camp Directory is now live. With one click you can find camps near you or sort by type of camp. From there, read about their features, get contact info and even watch a video.	cc/2020-05/en_middle_0111.json.gz/line2711
__label__wiki	0.754614	0.754614	Local Heritage/ Village Voices/ Alfred Enderby Fish Smokers Marshchapel Memories North Thoresby Memories Waltham Memories Tetney Memories Stallingborough Memories Photograph and Film Workshops Dialect Workshops Willow Growing and Basket Making Discover Local Crafts Telling Our Story: Village Voices celebrates £3,500 Heritage Lottery Fund grant North East Lincolnshire Council's library service is one of the first groups in the UK to receive a Heritage Lottery Fund (HLF) All Our Stories grant. This exciting project, Village Voices, in North East Lincolnshire and led by North East Lincolnshire Council library service, has been given £3,500. The project aims to tell the story of the rural traditions, trades and dialects of northern Lincolnshire through the voices of the people who are keeping them alive. All Our Stories, a brand new small grant programme, launched earlier this year in support of BBC Two's The Great British Story - has been designed as an opportunity for everyone to get involved in their heritage. With HLF funding and support, community groups will carry out activities that help people explore, share and celebrate their local heritage. The following sound clip is taken from the collection of recordings made during the project. The following clip is a sample of the discussions around changes in agriculture. Bob Dale, Wold Newton The following sound clip is a five minute excerpt of the documentry on village life. The full documentary is available for loan from Grimsby Central Library	cc/2020-05/en_middle_0111.json.gz/line2722
__label__cc	0.727313	0.272687	Dawn C. Sequeira The U.S. government’s effort to prioritize the immigration enforcement system has given foreign nationals the chance to obtain green cards. The Obama Administration established a working group comprised of officials from the Department of Homeland Security, including Immigration and Customs Enforcement (ICE), U.S. Citizenship and Immigration Services (USCIS), and Customs and Border Protection (CBP), as well as representatives from the U.S. Department of Justice (USDOJ), to identify best practices to focus the apprehension and removal of “high priority” aliens by, in part, limiting the initiation or pursuit of low priority cases. We are thankful for this effort and find it to be invaluable in our immigration practice. In essence, all immigration attorneys are technically given carte blanche (within reason) to make any request for a favorable exercise of the government’s discretion. We have experience making prosecutorial discretion arguments to ICE, USCIS, and the Department of Homeland Security’s Office of Chief Counsel (OCC). These requests resulted in deportation/removal cases being administratively (temporarily) closed or terminated (permanently closed) to allow eligible individuals to apply for relief with USCIS and prior removal orders being reopened to allow the individual to apply for relief. Prosecutorial Discretion requests also allow Notices to Appear (NTAs) to be issued, reissued, or cancelled and Deferred Action or Parole to be granted, among other discretionary enforcement decisions. Please give us a call to discuss your case. In-person consultations are available Monday through Friday from 8:00 am to 8:00 pm and Saturdays from 8:00 am to 5:00 pm. Please call our office at 301-529-1912 , text us, submit a request for consultation form below. Please be sure to provide a timeline of events along with details of your entire immigration history. H-2B Temporary Non-Agricultural Worker J Visa Waiver EB-1A Extraordinary Ability INA §212(h): A Waiver for Crimes More than 15 Years Old, Crimes of Moral Turpitude, Simple Possession of Marijuana, and Prostitution Visas for Canadian and Mexican Professionals (TN) O-1B (Extraordinary Ability) Nonimmigrant Visa Australian Professionals (E-3) EB-1B Outstanding Professor/Researcher K-1 Fiancé Visa Cuban Adjustment Act EB-2 National Interest Waiver H-1B Specialty Occupation H-3 Trainee Visa Naturalization Through Military Duty Adam Walsh Act Consular Denials [221(g)] Conditional Residence with Petition to Remove Conditions (Form I-751) Adjustment of Status (Green Card) & Section 245(i) Visa Waiver / Electronic System for Travel Authorization (ESTA) Advance Parole / Reentry Permit/ Refugee Travel Document Diversity Visa (DV) Lottery Returning Resident (SB-1) Legacy Immigration, LLC 10411 Motor City Drive, Suite 100 Bethesda,MD20817 dawn@legacyimmigrationattorney.com Legacy Immigration Scholarship Awards Faces of Bethesda Legacy Immigration Wins Huge Victory In Baltimore Immigration Court For Indian National With Multiple Marijuana Convictions Legacy Immigration, L.L.C. Copyright 2015-2019 All Rights Reserved	cc/2020-05/en_middle_0111.json.gz/line2727
__label__cc	0.679233	0.320767	I'm Buying Jordan Cameron. Here's Why You Be Should Too By Nick Schreck July 30, 2014 No Comments I saw Jordan Cameron coming last year, I can totally see the future. Okay so neither of those are true. I just spend more time than the average person reading fantasy football advice and studying stats. I, very luckily, took the advice of same fantasy football experts and took Jordan Cameron late in 2013 fantasy drafts. He proved to be a crucial piece early in the year, and even helped me win a championship down the stretch. I expect Cameron to have a great fantasy season for a few different reasons in 2014. Now I'm not the first person to expect big things from him, and I certainly won't be the last. However I believe that he isn't being overhyped as some other players are. I believe he's worthy of the praise, and can be a difference maker for your 2014 fantasy team. There are a ton of reasons I would love to own Jordan Cameron in 2013 and these reasons are just the beginning: The Absence of Josh Gordon Look, it's still unknown how many games Gordon will be suspended for in 2014. It could be the season or it could be less. Regardless of the length of the suspension, the worry is that without Gordon defenses will be drawn to Jordan Cameron and keep him from producing like he did in 2013. If we're being honest with each other, which we are, Jordan Cameron actually played better without Gordon in 2013. In weeks 1 and 2, during which Josh Gordon was suspended, Cameron averaged 7 receptions of more than 100 yards and roughly 1/2 touchdown a game. I see no reason Jordan Cameron can't produce those numbers again in 2014, however this time he'll have a better QB option than Brandon Weeden. The Quarterback Situation The Browns starting quarterback is still a toss-up between Brian Hoyer and Johnny Manziel, although early reports out of camp are that Hoyer is likely to be the guy. Assuming Hoyer wins the job I love Jordan Cameron's fantasy value in 2014. Just look at the chemistry the two had in 2013 prior to Hoyer going down with an injury. In weeks 3 and 4 Jordan Cameron averaged 8 targets, 11 receptions, 80 yards and 2 touchdowns per game. Assuming that chemistry still exists, there's no reason to assume Jordan Cameron can't produce similar fantasy numbers in 2014. He'll remain a red zone threat and a big body across the middle of the field. If Manziel wins the starting job, or becomes the starter at some point in the season, I still expect Cameron to perform admirably. Manziel is a talented player who will be able to make plays. Jordan Cameron is the perfect safety net and check-down guy for Manziel to learn in the NFL with. Regardless of the QB situation I expect them both to look Camerons way often. I've previously called the Cleveland Browns WR's a fantasy wasteland for fantasy players. I still believe that to hold true, save for a late round flier or two. What I do like about the offense heading into 2014 is the new offensive coordinator. We all saw what Norv Turner was able to do with Cameron, and we all know by now that Norv has a history of making tight ends perform. That's why many are chalking the loss of Turner up to a bad season for Cameron in 2014. However, the new offensive coordinator Kyle Shanahan is also a fan of his tight ends. In fact Owen Daniels produced for him while he was the OC in Houston. While with the Redskins, Fred Davis was on pace to have more than 1,000 yards before getting a 4 game suspension. In 2013 when Jordan Reed was healthy (8 games), Reed averaged 6 catches for 60 yards a game when he was the 3rd receiving option on the offense. I look at Jordan Cameron as the clear cut #1 receiving option for the Browns, even being a tight end. This offense may not appear valuable to many fantasy football fans, and they're right. However in the case of Jordan Cameron I recommend looking at all the pieces before writing him off. The Fantasy Value of Jordan Cameron in 2014 So I clearly can't predict the future, however I can gamble on it. I'm willing to gamble that Jordan Cameron performs for fantasy owners in 2014. He should improve on his 2013 fantasy numbers and I believe is worth his 6th round price tag. He's currently my 6th ranked tight end, and he'll be rising. Look for Cameron to provide some nice value for fantasy teams in 2014. When I put all of these pieces together, I see a fantasy player ready to explode. href="http://fantasyfootballpros.org/best-fantasy-football-team-names-2014/" data-color-override="false" data-hover-color-override="false" data-hover-text-color-override="#fff">Button Text	cc/2020-05/en_middle_0111.json.gz/line2733
__label__wiki	0.527427	0.527427	La porte étroite (original 1909; edition 1959) by André Gide (Author), André Gide 1,113 17 11,761 (3.67) 46 A delicate boy growing up in Paris, Jerome Pallisier spends many summers at his uncle's house in the Normandy countryside, where the whole world seems 'steeped in azure'. There he falls deeply in love with his cousin Alissa and she with him. But gradually Alissa becomes convinced that Jerome's love for her is endangering his soul. In the interest of his salvation, she decides to suppress everything that is beautiful in herself - in both mind and body. A devastating exploration of aestheticism taken to extremes, Strait is the Gateis a novel of haunting beauty that stimulates the mind and the emotions.… (more) Member: Samuel.Sotillo Title: La porte étroite Authors: André Gide (Author) Other authors: André Gide Info: Mercvre De France (1959), Mass Market Paperback, 182 pages Collections: Your library, Books Tags: Books, French Fiction, French Writer, French literature Strait is the Gate by André Gide (1909) Recently added by morganwhitman, Anderdot, bastbooks, mrattigan, NicholasOakley, bubblewrapped, BolstenDorder, xtofersdad, SleepySheep, Paul_Samael Legacy Libraries Gillian Rose, Hannah Arendt, Newton 'Bud' Flounders, Eeva-Liisa Manner Le Grand Meaulnes by Alain-Fournier (chrisharpe) The Guardian's 1000 Novels Everyone Must Read (608) Nobel Price Winners (45) Western World's Greatest Books - Project Gutenberg (257) My TBR (214) Canon de la narrativa universal del siglo XX (206) English (12) Italian (2) Dutch (1) Finnish (1) French (1) All languages (17) This is a truly exasperating story of a man's love for a woman and how the insanity of religion destroys it. If you need proof that religion is a mental illness, look no further than the painful story of Alissa. This probably isn't how the author intended it, but how can an intelligent person interpret it otherwise? Nice translation except that the translator leaves important quotes in French that you'll have to seek out on the internet if you don't read the language. The plot reminds me of a Jane Austen story--except filled with a pessimism that would have had Austen's characters drowning themselves by the end of the story. ( ) datrappert \| Sep 16, 2016 \| The entire novel is based on she loves me, she loves me not. If Alissa was so determined to act like a nun, she should have set Jerome free to love another. Instead she strung him along for years, never revealing her terminal illness. Very tiresome. I don't understand how Gide could have won a Nobel Prize for Literature for this book. A waste of time. ( ) 1 ShelleyAlberta \| Jun 4, 2016 \| Better known as "Strait is the Gate". This is the second French classic I have read translated by Walter Ballenberger. I appreciate the way he has put them into modern English without losing the flavor of France. I have only read one other book by Andre Gide, "The Immoralist". Both that novel and this one deal with people who choose to live their lives according to a guiding principle and where that decision takes them. While I could understand the main character in "The Immoralist" better, I had more sympathy for Alissa & Jerome in this novel. Both are quite short and would make a good introduction to this Nobel Laureate. ( ) 1 leslie.98 \| Feb 25, 2015 \| "I advanced slowly; the sky was like my joy---warm, bright, delicately pure. No doubt she was expecting me by the other path. I was close to her, behind her, before she heard me; I stopped . . . and as if time could have stopped with me, "This is the moment," I thought, "the most delicious moment, perhaps, of all, even though it should precede happiness itself---which happiness itself will not equal." (p 96) "Enter ye in at the strait gate: for wide is the gate and broad is the way, that leadeth to destruction and many there be which go thereat: Because strait is the gate, and narrow is the way, which leadeth unto life, and few there be that find it." (Matthew 7:13-14). This is the text from which Gide drew the title of his short novel, Strait is the Gate. It is a first person narrative that begins forthrightly with the words: "Some people might have made a book out of it; but the story I am going to tell is one that it took all my strength to live and over which I have spent all my virtue. So I shall set down my recollections quite simply, and if in places they are ragged I shall have recourse to no invention and neither patch nor connect them; any effort I might make to dress them up would take away from the last pleasure I hope to get in telling them." (p 3) The author signals in this short paragraph the importance of virtue (of what sort we shall find out) and that these are personal "recollections", subject to the vicissitudes of memory and desire, but not invented. Finally, the narrator claims to have pleasure, or at least hopes to, in telling them. One may see already the potential for the contradiction of truth presented as fiction and fiction telling the truth. The setting is the Protestant upper-middle-class world of Normandy in the 1880s. The narrator, Jerome Palissier, originally from Le Havre, is eleven when the story begins. His father having died he is living with his mother and a governess. He is surrounded by family including a creole aunt Lucille who alternately fascinates and terrifies him. She has two young daughters, Alissa and Juliette Bucolin, who are devoted to their father. Alissa and Jerome become childhood sweethearts and this gradually develops into a situation such that it becomes assumed, at least unofficially, that they are engaged. Unfortunately Alissa never truly agrees to any such arrangement. Complicating matters further are the feelings of Juliette for Jerome and the entry of Jerome's good friend Abel Vautier who quickly becomes infatuated with Juliette. The relations among these young people are complicated by the strength of youthful Eros, their own growth, and their search for identity. It is this search that leads Alissa in the direction of religion, in spite of which she professes to love Jerome. But she is no longer her former self and as Jerome is about to leave the country home of Fonguesemare where they have been together she claims that he has been in love with a ghost. Jerome replies that the ghost is not an illusion on his part: "Alissa, you are the woman I loved . . . What have you made yourself become?" Jerome leaves, "full of a vague hatred for what I still called virtue". Strong stuff for teenagers. Three years later he returns but their relations are never the same; the strength of her religious convictions has altered Alissa both spiritually and physically. The affairs narrated here are apparently drawn from Gide's own life, however loosely. Their are also parallels with Gide's own work as Alissa may be seen as corresponding to Michel, the protagonist in Gide's novel, The Immoralist, written about a decade earlier. Strait is the Gate presents itself as a small gem of a literary work. With its focus on the passions and desires of young love I am reminded of Goethe's Sorrows of Young Werther. Gide's biographer, Alan Sheridan, suggests that it is also a meditation on Gide's relationship with his own wife, Madeleine. Whether that is the case or not this short novel is has a beautiful clarity of prose and a haunting style that suggests the memories of young love that, while strong enough to leave permanent impressions, in some way become ghosts of one's youth. ( ) 1 jwhenderson \| Aug 24, 2014 \| As with most all of Gide's best novels, this one concerns the anxiety and yearning at the heart of human experience. A very young Jerome Palissier regularly spends holidays at the house of his aunt and uncle's estate in Fongueusemare in rural Normandy. One day, he happens upon his cousin Alissa, who is distraught at her aloof, hypochondriacal mother. Both desperate to rescue her and drawn by a genuine affection, Jerome takes it upon himself to sweep in and rescue her like a good, Christian knight errant. The subtle imagery of Jerome as a kind of salvific hero is only a foreshadowing of the religious unease that drives this novel forward toward its foreordained conclusion. As Jerome portentously declares, quoting Baudelaire, "Bientot nous plongerons dons les froides tenebres." Jerome and Alissa spend irenic summers together reciting poetry, reading from books to one another in their splendid garden, and enjoying music. The appropriateness of Jerome's name jumps out at you when he mentions another of their mutual literary interests: "We had procured the Gospels in the Vulgate and knew long passages of them by heart." (It was Saint Jerome who made the first Latin translation of the Bible.) Jerome wishes to become engaged before moving off to the Ecole Normale, but Alissa refuses. He is understandably upset by her rejection, but is only more spurred on by his ecstatic vision (again, that religious imagery) of eventually marrying her. Eventually, we learn that Alissa has sacrificed Jerome so that her sister, Juliette, will be able to get married first, yet even after Juliette gets married - to a boorish, business-minded vintner - Alissa continues to push him away. He visits her at Fongueusemare while finishing both his schooling and a military stint, but every time he mentions wanting to marry her, she rejects him and requests that he leave soon, that she cannot bear his presence. Eventually, she tells him that her love of God surpasses her love for him, even though she has always passionately loved Jerome. During their last meeting together, Alissa has grown thin and pale, presumably because of her anchorite-like existence; she has also removed the books of poetry and novels she and Jerome used to read together, and replaced them with works of cheap, vulgar piety. Even while there is room here to doubt Alissa's love for Jerome, a chapter that includes her personal journals makes it perfectly clear that she loved Jerome just as much as he loved her, if not more so. Jerome has a final meeting with Juliette while she is enceinte with her fifth child by the vintner. Seeing him calls to mind both her sister's Christ-like sacrifice and makes her reflect on her own uneventful, bourgeois life. As Flaubert said: "Madame Bovary, c'est moi." For maximum effect, as noted above, read this right next to Gide's "The Immoralist" for a most effective couple of case studies. Considering the year of publication (1909) and the ideas considered - repression, sexuality, sublimation - it should be noted that Gide almost certainly had Freud in mind when he was writing this, though it yields wonderful insights into human psychology even without a Freudian reading. When reading a novel, sometimes the most difficult obstacle to being able to truly and fully appreciate it is the historical change that has taken place between the time in which it was written and when you read it. Judging from some of the reviews I have seen, that seems to be the case with this novel, too. In both this and "The Immoralist," Gide looks at the tension, confusion, and repression that can often come about when romantic love is pitted against, and forced to compete with, love for the divine. Since this novel was published, this antagonism has almost completely died, which may lead some readers to accuse Alissa of being frigid. Once we are able to bridge that historical gap, however, and realize that Alissa did not see her torment as self-imposed but rather something that was required of her, this novel proves itself to be a superior meditation on both romantic passion and, what was once thought to be its opposite, sacrifice. ( ) 1 kant1066 \| Aug 15, 2011 \| Gide, André — primary author all editions confirmed Bussy, Dorothy Translator secondary author some editions confirmed 義雄, 山内 Translator secondary author some editions confirmed Frasconi, Antonio Cover designer secondary author some editions confirmed Nĳhoff, A.H. Translator secondary author some editions confirmed Is contained in André Gide : Romans - Récits et Soties - Oeuvres lyriques by André Gide The Immoralist / Strait is the Gate by André Gide L' immoralista: La porta stretta: La sinfonia pastorale by André Gide (indirect) Kitsas uks ; Valerahategijad ; Theseus by André Gide Strait is the Gate La porte étroite The Narrow Gate 1924 (English: Bussy) Alissa Bucolin Fongueusemare, Le Havre, Normandy, France Guardian 1000 (Love) Western World's Greatest Books - Project Gutenberg "Efforcez-vous d'entrer par la porte étroite" (Luc. XIII, 24) "Strive to enter in at the straight gate" (Luc. XIII, 24) To M.A.G. D'autres en auraient pu faire un livre; mais l'histoire que je raconte ici, j'ai mis toute ma force à la vivre et ma vertu s'y est usée. Some people might have made a book out of it; but the story I am going to tell is one which took all my strength to live and over which I spent all my virtue. A servant came in, bringing the lamp. Salamander (132\|132 en 285) Vintage Books with buckram reinforced bindings (V-27) Penguin Modern Classics (881) Swap (1 have, 23 want)	cc/2020-05/en_middle_0111.json.gz/line2736
__label__wiki	0.729847	0.729847	Photo: Overhead View of a Volcano Eruption By Live Science Staff 2012-08-17T19:11:33Z The Advanced Land Imager (ALI) aboard the Earth Observing-1 (EO-1) satellite captured an ash plume from one of the frequent eruptions of Indonesia's remote Batu Tara volcano on Aug. 15, 2012. On Aug. 15, NASA's Earth Observing-1 (EO-1) satellite caught a crystal-clear image of a small ash plume emanating from a tiny volcanic Indonesian island. The volcano, called Batu Tara, is located on the island of Pulau Komba, and has been experiencing frequent, mild eruptions since mid-2006, according to a NASA release. While much of the island appears green thanks to tropical vegetation, one side of the island is noticeably free of plants and appears grayish. This barren area is a scarp that drops from the summit of the volcano to the ocean, a distance of 2,454 feet (748 meters). The scarp is created by the frequent eruptions, which send rocks and ash barreling down the slope. The volcanic island is located in the Flores Sea and is part of the Lesser Sunda Islands. The first recorded eruption of the volcano, which happened from 1847-52, produced explosions and lava flows, according to the Smithsonian Global Volcanism Program. Batu Tara is a stratovolcano and the frequent eruptions is has experience recently are called Strombolian, after the archetypal Stromboli volcano in Italy. Strombolian eruptions are intermittent and feature explosive activity and lava fountaining, sometimes sending so-called "volcano bombs" into the air. Stromboli even has a scarp, called the Sciara del Fuoco, that resembles the one on Batu Tara.	cc/2020-05/en_middle_0111.json.gz/line2738
__label__wiki	0.75275	0.75275	Roasting? 7 Scientific Ways to Beat the Heat By Anne Harding 2014-07-25T17:24:05Z (Image: © unitypix/Shutterstock.com) Sweltering summer days aren't just oppressive and uncomfortable; they can be lethal, if the body's core temperature climbs much beyond 104 degrees Fahrenheit (40 degrees Celsius). Scientists studying people working under super-hot conditions — think firefighters, foundry workers and soldiers marching with fully loaded packs — have learned a lot about how the body handles heat. Beyond the basic advice of staying hydrated while avoiding sugary drinks, caffeine and alcohol, here are some evidence-based strategies for coping with our overheating world. Get used to it "Humans have a tremendous ability to acclimatize to heat stress," says Michael Sawka, a professor at Georgia Institute of Technology in Atlanta, who studies how humans adapt to extreme conditions. "You acclimate to what you're exposed to." But this doesn't have to mean hours of misery under the broiling sun. Spending just 100 minutes a day outside over four to 10 days is enough, to help your body adjust to functioning in warmer weather, Sawka says. Be in shape Being aerobically fit increases your ability to handle heat. "Training induces a lot of the characteristics that you typically see in somebody that is actually heat-acclimated," said Heather Wright, a research officer in the Flight Research Lab at the National Research Council Canada in Ottawa, who studies the effect of heat and other stresses on the body. A workout is like a mini-session of heat stress, she said. "With heat acclimation as well as with training, your resting core temperature decreases," Wright said. "As your temperature increases with exertion, heat and that sort of thing, it takes a longer period of time before your temperature reaches high levels, which are of concern." As anyone who's emerged from an air-conditioned car to set foot on sticky-hot asphalt can attest, "heat islands" are a real thing. Under the blazing sun, roofs and pavement can reach temperatures from 50 to 90 F (10 to 32 C) higher than the air temperature, according to the Environmental Protection Agency, which has a website dedicated to helping communities address heat island effects. For your own personal heat island escape, head for any patch of green you see, ideally one with some trees for shade. Plants not only block sun; they act like living air conditioners. "When the plant takes moisture up from the soil and exhales it through the leaves, you have evaporative cooling," explained Stan Cox, a plant breeder at the Land Institute in Salina, Kansas, and author of "Losing Our Cool: Uncomfortable Truths About Our Air-Conditioned World" (2012, The New Press). Take a rest Feeling overheated? Not only should you head for the shade or an air-conditioned room, but also you should spend longer there than you think you need to, Wright said. "It does actually take a while for your core temperature to start to decrease," she said. "Short breaks are usually not going to be enough to make a difference." That's because even after you're out of the heat, your core temperature will keep inching up before it goes back down. When you're feeling the effects of heat stress, regular breaks that are at least 15 minutes long are needed to reduce the increases in body temperature and cardiovascular strain, Wright said. Try to get to a cool or shaded area and allow time for your breathing and heart rate to slow to normal. Leave your sweat on your skin The human body has evolved to cope with heat by sending more blood to the surface of the skin to dissipate heat, and by sweating. Both of these processes become more efficient in fit people and with heat acclimation. To take full advantage of these built-in systems, don't wipe off sweat, but allow it to evaporate from your skin and cool you down, Sawka said. If you need a fast cool-down, plunge your arms into cold water up to the elbows, Sawka said. This trick — used often by firefighters and overheated military personnel — works to pull heat out of your body efficiently because your forearms have a high surface-area-to-volume ratio. Switch out light bulbs, and unplug Even a single incandescent bulb can generate a significant amount of heat. Per hour, a regular light bulb gives off 85 British thermal units of heat (one BTU is the amount of energy needed to heat 1 lb. of water by 1 degree F). For comparison, compact fluorescent lights give off 30 BTUs per hour, and light-emitting diodes give off just 3.4 BTUs per hour. Devices from computers to TVs to smartphones are also potent heat sources, so shut them off and unplug them if they aren't in use. Get passive-cooling aggressive A host of approaches can help you cool down your environment while using little or no energy, Cox said. People can put shades on south-facing windows, open windows at night to let cooler air flow in and close them in the morning before the day heats up, and strategically use open windows and box fans to keep air circulating, he said. Embrace public spaces Air conditioning may hog electricity, but it does boost human productivity. Several studies have shown that workers' energy drags as the temperature climbs. And nothing beats AC for coping with oppressive humidity, Cox said. Those who need to get some serious work done on a torrid day might search out a public library or coffee shop, where the cool environment will help you crank it out — and leave you more time for summer fun when you're done. Follow LiveScience @livescience, Facebook & Google+. Originally published on Live Science.	cc/2020-05/en_middle_0111.json.gz/line2739
__label__wiki	0.938002	0.938002	'Planet Nine' Video Among Winners of Science Visualization Awards By Kacey Deamer 2017-03-31T15:45:44Z This visualization of "Planet Nine" illustrates the discoveries being made in the Kuiper Belt, the uncertainty about the location of this hypothetical planet and computer simulations of distant areas in the solar system. (Image: © Patrick McPike, Mark SubbaRao and Mike Brown) Is there a distant ninth planet in our solar system? The short film "Planet Nine" makes the case, and was recently named the People's Choice for video in the 15th annual Vizzies Challenge. "Planet Nine" presents the evidence a ninth planet may be circling in the farthest reaches of the solar system, using visualizations to illustrate the scientific research into where this hypothetical planet may reside. The award-winning film is presented as a sky show at the Adler Planetarium in Chicago. "Our goal with this show was not to teach people about Planet Nine, and it certainly wasn't to convince them that the Planet Nine exists, " Patrick McPike, a visual engineer at the planetarium, said in a statement. "The show is really about the excitement and process of the scientific discovery. We hope that the show gets people more involved in science, whether that is by following science news more closely or by studying it themselves." Visual media is an important aspect of communicating science, and so the National Science Foundation (NSF) joined with Popular Science magazine to launch the Vizzies Challenge. From photographs to interactive applications, made by professionals or hobbyists, the Vizzies recognize the best visual representations of scientific research, according to the NSF. [See Images of Amazing Science Visualizations] Artists submit their work to the Vizzies Challenge, and from those hundreds of submissions a team of experts from NSF and Popular Science select 50 finalists. For the Expert's Choice winners, a panel of outside experts makes the decision. The People's Choice winners, however, are voted on by Popular Science readers. There is both an expert's choice and people's choice winner for each category: photograph, video, illustration, interactive, and posters and graphics. The winning artists' are awarded cash prizes, $2,000 for expert's choice winners and $250 for people's choice. This visualization of "Planet Nine" illustrates the discoveries being made in the Kuiper Belt, the uncertainty about the location of this hypothetical planet and computer simulations of distant areas in the solar system. (Image credit: Patrick McPike, Mark SubbaRao and Mike Brown) Winners this year included an artistic depiction of the human brain. Neuroscientist Greg Dunn, of Pennsylvania State University, and his Penn State colleagues combined several techniques, along with neuroscience data, to etch 500,000 neurons into sheets of gold for this image. It's "a reminder that the most incredible machine in the universe" is inside each of us, the team wrote in the statement. Another winning illustration shows the micropumping of a hummingbird's tongue. To capture the Zika virus in all its hideousness, David Goodsell, an associate professor at the Scripps Research Institute, combined 10,000 images made by cryo-electron microscopy. The result, which won a People's Choice award for illustration, reveals in breathtaking detail the envelope surrounding the virus along with the RNA (a molecule similar to DNA) that lives inside the virus, allowing it to replicate. One of the photos that was recognized by the Vizzies shows an 8-week-old starfish larva churning water to search for food. "A Hungry Starfish Larva" won the Expert's Choice for photography, and is part of a time-lapse video of the larva's water vortex. Science visualizations are not only striking, but also crucial in helping the public understand scientific ideas, according to Amy Schellenbaum, online director for Popular Science. "They are a great way to help a larger group of people understand the amazing occurrences taking place right under our noses every day," Schellenbaum said in a statement. The winners for this year's Vizzies Challenge are as follows: Photography Experts' Choice: "A Hungry Starfish Larva," by William Gilpin, Vivek N. Prakash and Manu Prakash. Photography People's Choice: "The Octobot, a Completely Soft Machine," by Lori K. Sanders, Ryan L. Truby, Michael Wehner, Robert J. Wood and Jennifer A. Lewis. Video Experts' Choice: "Network Earth," by Mauro Martino and Jianxi Gao. Video People's Choice: "Planet Nine," by Patrick McPike, Mark SubbaRao and Mike Brown. Illustration Experts' Choice: "Self Reflected Under White, Red, and Violet Light," by Greg Dunn, Brian Edwards and Will Drinker. Illustration People's Choice: "Zika Virus," by David S. Goodsell. Interactive Experts' Choice: "Flyover Country," by Shane Loeffler, Amy Myrbo, Sijia Ai, Reed McEwan and Alex Morrison. Interactive People's Choice: "ASL-LEX: A visualization of American Sign Language," by Naomi Caselli, Zed Sevcikova Sehyr, Ariel Cohen-Goldberg, Ben Tanen and Karen Emmorey. Posters & Graphics Experts' Choice: "Here There Be Robots," by Eleanor Lutz. Posters & Graphics People's Choice: "Micro-pumping Mechanism of Hummingbirds' Tongues," by Esther Ng. Original article on Live Science.	cc/2020-05/en_middle_0111.json.gz/line2740
__label__cc	0.65241	0.34759	T-Nutty Topping off his excellent moniker with brilliant nicknames like the Last of the Floheakinz and the Flowmastermouth, rapper T-Nutty came out of Sacramento, California with a grassroots marketing style and classic gangsta lyrics. The MC debuted in 2002 with the modestly titled LP The Gasoline, but by 2003 he got loose with the album Last of the Floheakinz, while 2005's The Nutt Factor Project proved he wasn't afraid to get wild. This dark sense of humor appealed to the likeminded Tech N9ne, who called upon Nutty for the 2007 Strange Music compilation Misery Loves Kompany. In 2009, he made a guest appearance on Tech's LP K.O.D., then Sac It Up and Serve It: Gas Chamber, Vol. 2.4 dropped in 2013 on the eOne label. His album Blue Venom followed in 2016, with guest appearances from C-Bo, J. Stalin, and Twisted Insane. Tenth set Return of the Floheakin arrived in 2018, featuring guests like G Swiv, Karasi, and Brotha Lynch Hung. ~ David Jeffries Luni Coleone Messy Marv C-BO X-Raided The Jacka Brotha Lynch Hung Killa Tay Mac Dre J-Diggs	cc/2020-05/en_middle_0111.json.gz/line2742
__label__cc	0.698733	0.301267	Authors Miren Agur Meabe MIREN AGUR MEABE Miren Agur Meabe. (Lekeitio, 1962). Teacher and basque philologist, she writes for adults and children and young adults, both prose and poetry. She received the Award from the Critics in 2001 and 2011 for the book of poems Azalaren kodea (The code of the skin) and Bitsa eskuetan (Foam in the hands), and also the Euskadi Prize of Literature for Young Adults three times for her works Itsaslabarreko etxea (The house on the cliff), Urtebete itsasargian (A year in the lighthouse) y Errepidea (The road). Her album Mila magnolia-lore (A thousand magnolia tree flowers) was included in the IBBY List of Honor in 2012. She is the author of the novel Kristalezko begi bat (One crystal eye), which got a warm welcome among critics and readers and it was translated into other languages. In the last few years she has participated in various international literary events. A YEAR IN THE LIGHTHOUSE Summer of 1936. War has just started and Jon arrives in Garraiceta, at the home of his uncle, the lighthouse keeper. He will spend a year living there, a year in which he will see his life and his environment changed. He will meet love and hate, friendship and treason, the big things and the lowest things regarding human being, together with the suffering and hopes of the people from his village. Obtained awards: - Euskadi Literary Award. Young Adults’ Literature 2007 - Nominated to contribute the IBBY Honor List 2008 - Liburu Gatzea (Young Book) Award 2008 WHAT IS LOVE BUT...? Two young people – Special and Mr X- are in love, but theirs is a secret love. Throughout this story, the two of them will try to answer the question that names the book by means of their reflections and their experiences. The many sides of this feeling (desire, jealously, commitment, doubts…) will appear in the personal point of view of each one of them. However, this couple is aware of the world that surrounds them: they are concern about poverty, war, climate change, domestic violence, inequality … and they show their commitment in their poems, or in the lyrics of the songs they write. That is the reason of so many references to music or literature. A work full of meanings, made of short chapters and that contains a whole book of poems inside it. A innovative story that is not read in just one direction but jumping from a narrator to the other one… just as love is: a two voices dialogue. Selected by Germán Sánchez Ruipérez Foundation to contribute “Lo + 2011” (2011 tops). Miren Agur has been awarded by the Literature Critics Award 2011. Pablo is just six years old, but he knows a lot about being a mom: he's been taking care of the little donkey Ross for some days now, pampering and educating him as if he was his own son. A tender story of friendship. MIREN AGUR, PREMIO DE LA CRÍTICA Miren Agur Meabe ha recibido el Premio de la Crítica Literaria en la modalidad de poesía en euskera DÍA DE LA PAZ Y LA NO VIOLENCIA MIREN AGUR Y SUS LIBROS JUVENILES El pasado mes de noviembre, en el marco del Hay Festival de Arequipa (Perú), tuvo lugar una conferencia de Miren Agur Meabe sobre diferentes cuestiones en torno a sus libros juveniles.	cc/2020-05/en_middle_0111.json.gz/line2745
__label__wiki	0.977894	0.977894	John Jay tops Rye, gets Yorktown next Shawn Smith led the Indians with five goals John Jay tops Rye, gets Yorktown next Shawn Smith led the Indians with five goals Check out this story on lohud.com: http://lohud.us/1gtCCqc Mike Dougherty, TJN Published 11:10 p.m. ET May 15, 2014 \| Updated 11:23 p.m. ET May 15, 2014 From left, John Jay's Shawn Smith and Ryan Lee celebrate a first-half goal by Smith.(Photo: Frank Becerra Jr./The Journal News)Buy Photo Chris Santangelo scored three goals in the loss for Rye Eighth-seeded John Jay cranked up the offense and sent Rye home with a decisive 11-6 victory in a Section 1 Class B opening-round game. CROSS RIVER – There has been a fair amount of head shaking in the days since the brackets were released. Traditional powers like John Jay and Yorktown usually meet somewhere along the way during the Section 1 tournament, but not in the quarterfinals. It's been an odd season. Another meeting between the rival programs was set up when the eighth-seeded Indians cranked up the offense and sent Rye home with a decisive 11-6 victory in a Section 1 Class B opening-round game Thursday. They will get together at Murphy Field on Saturday. Game time is yet to be determined. The Huskers won a March 29 meeting 11-6. "Actually, we're very excited," said John Jay defender Graham Bocklet. "I'd rather be able to play them another game than anybody else. They're a rival, so it's nice being able to play them. We had our bumps in the road this season, but we've gotten a lot better." Class B: John Jay defeated Rye 11-6 From left, John Jay's Shawn Smith (24) and Ryan Lee (22) celebrate a first half goal by Smith against Rye during a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. John Jay won the game 11-6. Frank Becerra Jr./The Journal News From left, John Jay's Ryan Lee (22) fires a shot over Rye's Drew Abate (33) for a first half goal during a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. John Jay won the game 11-6. Frank Becerra Jr./The Journal News From left, John Jay's Shawn Smith (24) fires a shot for a first half goal against Rye during a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. John Jay won the game 11-6. Frank Becerra Jr./The Journal News From right, John Jay's Jack Wertz (6) gets off a shot just as he gets hit by Rye's Zach Holmes (13) during a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. John Jay won the game 11-6. Frank Becerra Jr./The Journal News From right, John Jay's Shawn Smith (24) gets off a shot just as he gets hit by Rye's Zach Holmes (13) during a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. John Jay won the game 11-6. Frank Becerra Jr./The Journal News From right, John Jay's Josh Rubin (1) celebrates his first half goal in front of Rye's Laz Chavez (24) during a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. John Jay won the game 11-6. Frank Becerra Jr./The Journal News From left, John Jay's Josh Rubin (1) celebrates his first half goal against Rye with teammate Graham Becklet (15) during a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. John Jay won the game 11-6. Frank Becerra Jr./The Journal News John Jay defeated Rye 11-6 to win a boys lacrosse playoff game at John Jay High School in Cross River May 15, 2014. Frank Becerra Jr./The Journal News The ninth-seeded Garnets (8-9) were extremely patient from the start and had the ball most of the first quarter, but the Indians (11-6) had the lead when it was over. Shawn Smith was clearly not ready to end his scholastic career. The senior attackman got John Jay on the board four minutes in when he found a seam and went full-speed to the crease for a goal. He got loose and skipped in another a short time later to make it a 2-0 advantage. Smith finished with five goals. "It was a rough season for me individually," the Michigan-bound senior said. "I didn't do as well as I wanted, but I know the playoffs is where you leave a legacy. I came out like this game could be my last, and it showed." Ryan Lee tacked on another goal in the final minute of the quarter, making it 3-0. Rye couldn't manage to find answers. It was an 8-2 Indians lead after Matt Lupinacci threw in a pair of third-quarter goals. "We didn't end the season quite the way we wanted to," Smith said. "We know this is where our season is made, in the playoffs, and I think we looked completely different than we have the last couple of games." Chris Santangelo had three goals for Rye. John Jay has played in a Section 1 championship game nine straight years, and lost to the Huskers last spring by an eye-popping 17-3 margin. "We have to slow Yorktown down," Bocklet said. "That starts with us slowing the ball down on offense, slowing the game down. We have to press out on their attackmen. We can't let them fire at our cage. We have to help (goalie) Rob Looney out a little bit. We have to try to make it a low-scoring game." Twitter: @lohudlacrosse Follow The Lohud Boys Lacrosse Blog at boyslacrosse.lohudblogs.com/	cc/2020-05/en_middle_0111.json.gz/line2746
__label__wiki	0.552811	0.552811	Valentina Ferragni returns to the Rue des Mille Home and signs the "Winter Capsule" After the success achieved with the "Summer Capsule", the first jewellery collection created last summer for the Rue des Mille brand, Valentina Ferragni relaunches putting herself back in the game and signs the second collection, the "Winter Capsule". The collection designed by Ferragni takes inspiration from the fashion of the 80s that has already marked the season's trends for a few months: “I drew inspiration from the oversized chains and the bold lines that went so much in those years and which are still found today in flea markets all over the world. It is precisely here that, following my passion for vintage jewellery, I discovered truly unique pieces that I indulged in reinterpreting, using a great classic, yellow gold, illuminated by sparkling stones. In this collection, the influencer specifically wanted to maintain some distinctive features present in the previous “Summer Capsule”, such as little hearts and the star and heart-shaped earrings declined in a retro and ultra-bright key, a tribute to the most glittering festivals of the year, Christmas and New Year. “So, important jewels were born, studded with stones and capable, on their own, of dressing a woman. Jewels that want to give a strong signal, for women who love to fight to realize their dreams but without fear of appearing or affirming their femininity. " The "Winter Capsule", designed by Valentina Ferragni for Rue des Mille, was produced entirely in Italy, with handcrafted manufacturing, and made of 925 silver, yellow gold plating and white zirconia. The Limited Edition collection consists of 7 pieces: a choker, a bracelet, an ear cuff, two pairs of earrings, a single heart and star earring. The chain is the dominant theme, a symbol of strength and resistance, but also solidarity and female collaboration. "A line that follows the hottest trends of the moment, ideal for modern city princesses who struggle every day to turn their dreams into goals to achieve," says Federica Pieroni, head of marketing and communication at Rue des Mille. Valentina Ferragni's "Winter Capsule" for Rue des Mille will be for sale from November 20 until January 15, in a selection of over 300 Rue des Mille retailers and on the brand's e-commerce. At the Rue des Mille Milan Pop-up store (via Monte di Pietà, corner of via Borgonuovo) Ferragni's "Winter Capsule" will be for sale from tomorrow to 26 December. Gloria Reali	cc/2020-05/en_middle_0111.json.gz/line2750
__label__wiki	0.791882	0.791882	19 Dec Featured Album 2015: Frankie Lee – American Dreamer We’ve released 7 albums this year, so each day this week we’ll be featuring one of those albums and marking down their prices in the Loose Shop, for just this week. Today it’s Frankie Lee’s American Dreamer. THIS YEAR: Frankie Lee’s debut album was released throughout Europe in September and greeted with much excitement (check out those quotes below), bringing Frankie across the pond to Europe for the first time. NEXT YEAR: Details of the long-awaited and much anticipated US release of Frankie’s debut are due to be revealed soon, with more European shows on the way… THE 50 BEST SONGS OF 2015 – Where Do We Belong TOP 50 RECORDS OF 2015 – #26 CLASSIC ROCK Germany “the debut album of the year” ROLLING STONE France “the hot tarmac romance of a roots rocking War On Drugs” “beautifully burnished Americana” “a traditional-sounding debut, but wild and radical at heart, and should take him a long way” “a rich and understated debut” “one of the most intriguing new songwriting talents to emerge this year.” SONIC MAGAZINE Sweden “heart-achingly good melodies” GIGSOUP “an album of classicist Americana imbued with grain, wisdom and a quietly questioning authority” “the start of what promises to be a very exciting and significant new arrival on the Americana scene” FOLK RADIO RENOWNED FOR SOUND “think Sturgill Simpson, Corb Lund and aforementioned [Bap] Kennedy, a musical rebel who likes to feel the wind in his hair.” AMERICANA UK “A single spin of American Dreamer underscores just how much promise Lee has as a musician -consistently excellent” PITTSBURGH IN TUNE “an exhilarating first album” ROCKAWA “like Mazzy Star had discovered the Heartbreakers” SOUTHERN DAILY ECHO “Frankie Lee reveals a debt to both Bob Dylan and Bruce Springsteen, especially in a vocal delivery which sits somewhere between the laconic (Bob) and the plaintive (Bruce). Musically, though, it’s the latter who provides the more obvious template, with perhaps a little of Kurt Vile’s grungy Americana thrown in.” “Where Do We Belong, the debut single from Mississippi-born nomad Frankie Lee, has something special about it; what was once known as an X factor before Cowell and co. irreparably ruined the term.” GET IN TO THIS “a fine debut from someone who promises to be a major new Americana voice” R2 MAGAZINE “The best debut album of the year” DUST OF DAYLIGHT, Norway “excellent debut” PETERBOROUGH TELEGRAPH	cc/2020-05/en_middle_0111.json.gz/line2754
__label__cc	0.50398	0.49602	[Those who have not yet submitted their selection are still invited to do so; but from this point on, for sanity's sake, I have to keep it limited to those I originally contacted (i.e. the folks on my blogroll; if you're there but were not reached yet, consider yourself invited).] I originally wrote a very long intro to this piece, but that's been discarded and I'll try to keep it succinct [not sure how well I succeeded now that all's said and done - ed]. This is a tribute to the past year of celebrating movies & a blow against the ephemeral nature of the exercise; in asking bloggers to select their own best work for the year (the full list follows after the jump) I'm hoping we can take another step beyond the purely chronological approach to blogging, in which our best work slips away once it slides down from its perch atop our site. Before introducing my selections from my own work, I want to thank 3 people who hosted me under their own banners in 2009 - this was a year in which I expanded my reach beyond just The Dancing Image and they helped facilitate that process. First I must mention Sam Juliano, who has weekly linked to my Examiner essays, and whose website Wonders in the Dark has become a hot-spot for a certain corner of the blogosphere. The main hook is his colleague Allan Fish's original, extremely erudite decade countdowns, in which he celebrates what he considers to be the best of each ten-year period, with often surprising - but always well-informed and thought-provoking results. I have rounded up the complete list so far and of course one of his pieces, actually an introduction of sorts to the series, is linked below. But once curious visitors arrive on the site, it's Sam - the site's founder - who keeps them there with his peerless generosity and enthusiasm and tireless administration of the site (helped by the technical facility of Tony D'Ambra, another longtime friend of this blog). He has fostered a community on Wonders in the Dark, a diverse band of commentators from all backgrounds and of all opinions, who share only a thrilled adoration of the cinema. It's no exaggeration to say that the best, most stimulating, most entertaining, most thought-provoking, and certainly the most freewheeling discussions I've ever had on the web - and perhaps off it as well - have occurred on Wonders in the Dark. Sam's best qualities are on full display in the piece I've chosen to highlight from him: Sam Juliano, Wonders in the Dark, "Wonders in the Dark One-Year Anniversary: Dedication, Chemistry, Luck, Countdowns, and a Superstar Named ‘Dee Dee’" Next up I want to tip my hat to someone who goes way back with The Dancing Image: Tony Dayoub. He first emerged on these pages in August 2008, when I was deep in the throes of my initiation into the "Twin Peaks" universe. Tony's been a fan of the series for years, and his comments, brimming with little-known facts and personal experiences with the show, were a revelation. Since then, I've discovered he's a model blogger in many ways - participating in all the various activities which characterize the form (blog-a-thons, memes, list-making, capsule reviews, etc.) without ever succumbing to the amateurism that occasionally characterizes blog posts, mine included. If there's a future in this blogging thing, Tony is helping to light the way. This year he initiated and hosted a Brian De Palma blog-a-thon in tribute to the filmmaker's 69th birthday. He posted a particularly adventurous piece of my own, which eschewed writing altogether (and is highlighted below) - for that and for his praise of the piece I am eternally grateful. The series climaxed with Tony's own essay, a masterful yet never unwieldy piece which perfectly weaves together all his strengths: an unpretentiously personal engagement with the work, an appreciation for the nitty-gritty of a film's details without losing the big picture, and a remarkably astute understanding of context (probably his greatest asset) - historical, auteurist, cultural, you name it. The essay discusses Scarface, Carlito's Way, and Tony's own experiences with both as a Cuban-American kid growing up in Miami and later a die-hard film buff. Tony Dayoub, Cinema Viewfinder, "De Palma Blog-A-Thon: Scarface (1983) and Carlito's Way (1993)" Finally, there's Ric Burke, a.k.a. Ibetolis, who made a home for me and many others for several months this year when he plowed his way through the first half of this decade with his series "Counting Down the Zeroes." Two of my pieces were posted on his site, both on underrated films which I probably would not have written about without his encouragement (I've selected one amongst my strongest pieces of the year). Though the project has been put on hold for the moment, I hope it will return; "Counting Down the Zeroes" served as a Who's Who of the blogosphere, with new writers showing up every day to tackle hits, obscurities, and even black sheep. Here is Ibetolis' intro to the series, after which he stepped back and put on his editorial hat for the duration: Ibetolis, Film for the Soul, "Counting Down the Zeroes" Before moving on to the entree, lest you think this is entirely an exercise in modesty, let me point you to the work I'm proudest of from this past year. There are four here (more are highlighted at the bottom of the post); while there are other pieces I'm happy with, they aren't really well-rounded enough for me to put at the top. That said, these four (listed alphabetically) are quite diverse. The first - largely overlooked at the time, but probably my most worked-over piece, is a video (which should be watched with caution if there are sensitive eyes around, be warned); the second and fourth are rather long essays - though one is pretty tightly-wound and the other is more bombastic; and finally there's probably my most popular piece of the year, a mixture of pictures and prose, which initiated a widespread response. Hopefully, "Reading the Movies" sums up the spirit that brought us all here in the first place. 1. directed by Brian De Palma 2. Lawrence of Arabia 3. Reading the Movies 4. Waiting for the 25th Hour So that's that. Now, for the main attraction, a round-up of the years' best according to the authors themselves, with selections (usually words, sometimes pictures, in one case a video) from the work itself. "Life and death mixed together in a ghoulish romp, with Boop encased in ice as a temple sacrifice. It all fits beautifully together to make SNOW WHITE one far-out pinnacle in pre-code cartoon surrealism. In those days the Harlem clubs were where one went to frolic without the peepers of the law on your ass, so miscegenation, reefer-toking, hops, homosexuality, the threat of violence was all in the air making excitement and giddiness de regeur... and the Fleischer brothers, two very hip Jewish cartoonists, captured that sense of danger the next day at their midtown animation studio." -Erich Kuersten, Acidemic Film, "Acid Shorts #1: Betty Boop in SNOW WHITE (#33)" "But keep watching the original “Abraham”. Louise Beavers turns the scene on its ear. The warmth and sincerity she exudes singing to her children is what makes Bing and Marjorie all the more silly. She has dignity, and this was Abraham Lincoln’s great gesture to his fellow Americans of every race, the idea that human beings were born with innate dignity, and nobody could take it away from them, even if they took away their freedom. People can only give up their dignity willingly, which is what Bing and Marjorie are doing in this scene." -Jacqueline T. Lynch, Another Old Movie Blog, "Abraham" "Cumulatively, the two films show more naked human flesh than a doctor is likely to see in his entire career. Irreversible flaunts it so routinely that it becomes unsurprising whereas Salò materializes the physical body, reducing the strategically placed figures to pawns on a chess board, forever inferior to the dominant Kings. On that note, Salò is almost, dare I say, recommendable for its formal rigor; nearly every composition is of intense mathematical symmetry. Similarly, if one can handle the arduousness of Irreversible, what emerges is a thought-provoking study of the nature of time, littered with unbelievably difficult set pieces." -Carson Lund, Are the hills going to march off?, "Irreversible and Salo (2002/1975) Films by Gasper Noé and Pier Paolo Pasolini" "Of these three ecosystems of the damned -- and I can express this sincere contempt unabashedly, having been raised in one -- the final is closest to the backdrop of 3 Women; two of the major characters in the film are employed in a geriatric therapy facility offering hot mineral baths and the like (a common offering in high desert vicinities that have the advantage of a sulphur spring natural resource). And at one point Shelly Duvall's "Millie" bitches about having moved her ex-roommate "all the way to Riverside". Judging from the terrain and the flickering fata morgana of despondency, I would place the affair in one of the glorified truck stops that populate the 15 freeway past Barstow. On family trips to Vegas my parents would typically lurch up the pearblossom path in an effort to take the city (and its eternal traffic) by surprise; while shielding my eyes from a dirt storm en route to a Texaco men's room I often recognized more of the Land of Enchantment in the Native totems and O'Keefe-like arid eroticism than the Golden State." -Joseph "Jon" Lanthier, Aspiring Sellout, "My One Horse Town Libido is an Abandoned Miniature Golf Course" "The tragedy of Cinema is that we are looking through a one-way mirror at a world that is unreachable, that is blind and alone. I have never seen a film where the screen has felt so thin, the story so immediate and raw as it does in Fire Walk With Me. The screen, though, is still too thick to smash, too thick to allow us to intervene. -Stephen, Checking on My Sausages, "Twin Peaks: Fire Walk With Me (1992), dir. David Lynch" "The Outer Circle was in the nowhere zone between DC and Chevy Chase, MD where you're not quite sure what city or state you're in. There were diners, banks and gas stations nearby. That doesn't mean much now I suppose but NOT being in a multiplex by a mall or a Disney-fied Downtown gave it a very different feeling that is hard to describe now. There was a feeling you could be walking down the street and suddenly happen upon a cinema next to the Phillips 66 and say to yourself or your walking companion, "Hey, want to see a movie?"" -Greg Ferrara, Cinema Styles, "History and the Movies IV: There Are Places I Remember" "One could easily mistake such words about the Welles' landmark film as damning, but Farber is really just saying, sure, it worked great in Kane, and the film was innovative, but the cult of Hollywood filmmakers that sprung up around the film has learned the wrong lessons from it. He goes on to lament the virtual extinction of the naturalistic film, wondering if Hollywood will ever "be able to go home again."" -Tony Dayoub, Cinema Viewfinder, "Book Review: Farber on Film Part 1: "The Gimp" and Its Implications on Contemporary Cinema" "I stalled as long as I could in the hopes that wisdom would reach down to me from the heavens like a funnel cloud, but after two trips to the theater and several weeks of pondering it’s time to face the facts: A Serious Man has me seriously befuddled. It’s a clever film, to be sure, effortlessly weaving together Schrödinger’s cat, the Book of Job and Jefferson Airplane as if they are natural companions. It’s an amusing film, too, though I’d stop short of calling it “audaciously funny” or “seriously funny,” as Owen Gleiberman and Peter Travers apparently did, according to the promotional postcard. It’s a remarkably well acted film, even though its biggest star is Richard Kind, a career “that guy.” It’s also beautiful to look at because, well, Roger Deakins shot it. And yet for all the ways I can think to praise this latest effort by Joel and Ethan Coen, I am overwhelmed with the sense that something is missing. And what’s missing, I think, is the sense of being overwhelmed." -Jason Bellamy, The Cooler, "A Goy's Beef: A Serious Man" "Midway through the movie, as the chords to "Jealous Lover" fill a Chinese restaurant, Fran recites the lyrics to The Ballad of The Other Woman. She sits in front of a married man...a married man she truly wants. But as he starts into his promises, she surprises him - and us - by rhyming off the married man's bible, chapter and verse. She's made this mistake before, more than once it would seem. Enough times to know what's coming, but not enough to step out of the way." -The Mad Hatter, The Dark of the Matinee, "Back to Basics: THE APARTMENT" "Will Hunting, in the Clinton '90s, first holds a job where he cleans floors at MIT—of all the places to clean—and then when he quits it, he can work construction. Bills aren't a problem. Rocky Balboa, on the other hand, aspires to a desk job (and its concomitant financial security) which he can't get, and must beg around for menial labor in the recession '70s. He gets a job hauling beef and promptly loses it for reasons of budget. Choices are made, in Rocky and Rocky II, on the basis of a dream, sure, but also in light of setting food on the table; the latter in the contemporary-liberal "working class" Hollywood fantasy is more likely to be excised from the picture, replaced with pap about realizing one's true potential, etc." -ZC, Elusive Lucidity, "Yo, Rocky" "I think everything Paul Thomas Anderson makes is worth watching and would say he's the closest thing we currently have to an American auteur that fits the mold of a Kubrick or an Altman or even a Scorsese (each of whom I single out because those also seem to be the styles he is drawing from on THERE WILL BE BLOOD, MAGNOLIA, and BOOGIE NIGHTS, respectively). To be compared favorably to those men is a sure sign that PTA is a damn good director. To be able to successfully tap into the style of each and yet still retain a sense of his own style shows that he a great director. Of those three aforementioned movie, MAGNOLIA is the only one that I think is brilliant and yet has too many moments that ring emotionally hollow for me to claim it as his masterpiece." -Troy Olson, The Elusive Robert Denby, "Best of the 90s -- a near classic and a surprise" "The other thing about reviewing film is measurement. A thumbs up, thumbs down approach might be too vague, but a meticulous numerical form could be too stratified. And what do you do when you like a movie but don’t think it was that excellently constructed. Or vice versa: you’re faced with a well made but emotionless and clinical piece. Which gets the higher grade? Which is the “better” film?" -Andrew, Encore's World of Film & TV, "It's Hard Out There For a Blogger" "The people are without a doubt the focus of the film, but the motels themselves are pretty interesting as well. They aren't the cockroach infested pits you might have in mind and actually look to be extremely clean, freshly painted and quite lovely. They have private garages and back entrances, but otherwise look like reasonably nice places to stay - that is as long as you don't need a suitcase stand and don't mind mirrors on all sides. If you're looking for a last minute room though, avoid trying to check in between noon and 2PM on a weekday. During this peak time many office workers in Miami, according to one of the guests, go to motels instead of restaurants. Apparently they are used to dealing with their hunger pangs." -Bob Turnbull, Eternal Sunshine of the Logical Mind, "Love At The Twilight Motel" "It turns out that my father actually was a war casualty, though it took 40 years for the asbestos (even then, a well-known carcinogen) he was exposed to on the repair ship to kill him. When Dad became a manager at his insurance company, he was charged with firing workers, a job that broke his heart, especially when the worker had a family to support. As an independent supplier of copy machines, he could not compete with big companies like Xerox, though truth to tell, my father was no businessman. When he tried to sell uniforms to the City of Chicago, he was bewildered that none of his bids ever won. Schmuck, a ward heeler would have said. Who the hell is Art Ferdinand? Who sent him? Even I knew that. The fact of the matter is that my father was the kind of man about whom Arthur Miller wrote his great tragedies. From falling victim to the indifference of the Navy to the asbestos danger on his ship, which echoes the tragically avoidable deaths of Miller’s All My Sons, to being a man like Willy Loman, better suited to working with his hands than trying to get ahead in business, even as the mildest version of a corporate cutthroat, my father’s American Dream was a fitful one." -Marilyn Ferdinand, Ferdy on Films, etc., "Death of a Salesman (1985)" "My favourite song when I was six was Jackson’s “Beat It,” in alternation with The Boss’s “Born in the USA.” Such was the ubiquity of that era’s hits that it was indeed possible for kids who had neither experienced the diplomatic niceties of African-American street gangs or the dubious pleasures of being a disaffected Vietnam vet to shout along to those epic choruses without any trace of cognitive dissonance. It was a time of such ambitions and contradictions. The lingering shades of the Counterculture were reduced to jokes fit for Family Ties. Madonna could extol feminism by stripping, Jackson could happily shill for Pepsi, and both could make these look like triumphs for the subcultures that nurtured their ambitions. That epoch met its infamous Gotterdammerung when Jackson’s Black or White video gave way to a bunch of sweaty, grotty, substance-altered teenagers fresh dancing to Nirvana in what looked like a dreamscape high school auditorium where Freddy Kruger would turn up and begin butchery." -Roderick Heath, Ferdy on Film, etc., "Cinema/Pop: The Art of 80s Music Video" "3. Sam says the first line--"Never did eat your lunch, did you?" as we see a rapid insert shot of a sandwich on a table. In this fashion, Hitchcock immediately associates eating with sex and excretion (the bathroom). Marion has no need for lunch because she's satisfied her "ugly appetite" (to quote Norman's mother) another way. All of this and an upcoming shower scene make the normally innocent bathroom a chamber of existential dread. Much of the rest of the dialogue is exposition, but I like the way Sam says "Turn momma's picture to the wall?" as a way to characterize what fun they would have after an evening of respectable dining. Hitchcock loves to rely on photographs, paintings, stuffed birds, mirrors, and anything else on the walls to convey significant mise-en-scene. He even did that in his television show Alfred Hitchcock Presents. -Filmdr, The Film Doctor, "'Turn Momma's Picture to the Wall': notes on the beginning of Hitchcock's Psycho" "And always, following the character is an almost Gregorian soundtrack, reminiscent of the chant of the Elders in the Huddle sequence near the beginning of the film, and repeated in defiance of the dancing below again near the end. When Mumble is awoken from his dormant egg early on in the film, it’s by the tapping on the shell by baby Gloria. Later on in the film, it’s this same rhythmic tapping, on the glass of the aquarium exhibit, that startles him from his emotional death – and into a rebirth, in a sequence that returns Miller to what he’d found so fascinating about cinema in the first place, images without sound, “visual music” in the clearest sense." -The Filmist, The Filmist, "Best of the 2000's - #3: George Miller's 'Happy Feet'" "The dark night of forsaken city streets, vistas of blissful angst and unholy pilgrimage. I have been there and known their inhabitants: deadly dames, drunken losers, dangerous hoods, crooked cops, dreamers of broken dreams, and flawed heroes. LA, Frisco, Chicago, and New York. I know these cinematic cities though I have never been. A resident knows his locale, but the city in its ectoplasmic center is not reached corporeally, only in the phantasmagoria of a thousand and one shards of shattered night. Luminescent environs of a cosmic b-movie. Wet asphalt, fog-laden piers, deserted streets, rusting hulks at anchor, the neon glimmer of purgatory dives, cigarettes and booze, dark tenements, the skid of car tires, and the wailing sirens of the dead. Staccato rhythms and aching horns, crowded pavements and desperate loneliness." -Tony D'Ambra, Film Noir, "Noir Fiction" (nine posts & two pages' worth of Tony's impressionistic prose, a moody tribute to the films he otherwise celebrates in erudite capsules on his blog) "Having recently watched Brazil, and as one is wont to do with an interesting film, I actually discussed it with friends, one of which went on to tell me that Michael Pallin's character was one of his favorite characters in film history. This of course got me thinking about my own personal most influential and/or favorite characters and so here we are. But rather than declaring, I felt more like learning, so I thought I'd spread a little meme around. Following the standard meme structure I'm tagging five film bloggers and asking them 'What are your favorite 10 characters in film?'" -Squish, Film Squish, "Favorite Film Characters Meme" (Squish says the meme is still in effect if you want to participate; my own entry, from last spring is included near the bottom of this post) "It was through the Cineaste debate that I came across these shocking statistics: "There are an estimated 113 million blogs out there, and 112 million seem to be about film". Now, it is great that there are so many opinions out there but there is also a lot to search through and it takes something really special for one blog to stand out amongst the rest. One of my favourite things to look at in other people's blogs is the blogs/websites they follow. It's like an endless chain leading you to more and more interesting information." -filmgeek, Final Cut, "Film journalism in the digital age" "This will be an interesting write-up, as so much of what I am attempting to communicate has to be experienced to be appreciated. And at times it might read like something of a love letter, which will be interesting for a lot of folks because I’m almost certain that some readers will completely abhor this film. I’ve been anxious to reach this year in the countdown so I could try to get down some thoughts on this movie, and also because I am eager to see if there are others that are as enamored by it as I am." -Dave Hicks, Goodfellas Movie Blog, "2005: The New World (Terrence Malick)" "What right-thinking Paramount star hopeful would agree in 1941 to don tights and a cape? Could Sterling Hayden, Jon Hall, or Robert Preston ever have lived that down? Paramount might spend millions and still end up with another Doctor Cyclops. Dave Fleischer told of quoting big numbers to animate Superman and Paramount unexpectedly agreeing, his look-back suggesting a giant brought to heel by independent Fleischers who could take this commission or leave it. Paramount doubtlessly bristled if such was the case. Where did this Florida shop get off telling New York what cartoons it would or would not make? Max Fleischer’s lavish operation was an iron lung with Paramount supplying the air. Unplug it and the patient dies. I’ve got the feeling Superman had lots to do with erosion quickening between them. It didn’t help that the Fleischers were themselves quarrelling (in fact, Max and Dave stopped speaking). For Paramount sharks, that was like blood on the water, but more of this anon." John McElwee, Greenbriar Picture Shows, "The Fleischer/Paramount Supermans" "Mr. Dink -- Jeff Garlin Surprisingly, this was the very first face to pop in my mind when I saw the picture of Mr. Dink. Doug's eccentric neighbor was often one of the funnier characters on the show and anyone familiar with Garlin knows how hilarious he is. If you haven't watched "Curb Your Enthusiasm" before, now is the time. Garlin's really perfect for this role. He's got the build, the unique voice, and the humor. Maybe someone should just make a live-action Mr. Dink movie. Screenwriters, start typing." -Elgringo, He Shot Cyrus, "Casting the Live-Action DOUG Movie" "I’m still not sure what I qualify an “essential” film about women, I hope my list presents a huge cross-section of different kinds of women and experiences, but at the very least I’m looking for films that have at least one female protagonist, which rules out a lot of films that may have interesting or strong female supporting characters and roles unfortunately. I’m also not attempting to paint only a positive portrait of womanhood, I think many of these film reveal many imperfect, even downright cruel women… but that is part of a reality." -Mrsemmapeel, House of Mirth and Movies, "The Unofficial Female Film Canon" "I am never going to forget this film. Not for as long as I live. Not for as long as I hold onto the love of cinema that I have always struggled so hard to keep kindled—keep burning—through anything; through thick and thin; through the lack of interest in filmmaking circulating in the grade schools, middle schools and high schools that I passed through and graduated from; through the overwhelming political apathy that has stung the state of Missouri in which I reside. It has been a long time since a contemporary film has held up a mirror to my face and shown me the kind of thinker, viewer, and audience member that I am. I found such a film in Redacted. It was the Brian De Palma film that I had always waited for. It is still the fiery, passionate film that will haunt me, provoke me, and perhaps even influence me when my future career comes knocking." -Adam Zanzie, Icebox Movies, "Redacted" "Golda Meir of Munich There are those hulking figures who instantly read menace with their furrowed brows and bulging muscles. And then there are the grandmotherly types who will serve you tea and send you on a suicide mission. The latter scares me much more because you don't see them coming. I admire Golda's modesty, but know that beneath that simple dress she wears there's one hell of a bat and she knows how to use it." Piper, Lazy Eye Theatre, "10 Characters I Love, Understand, Fear and Feel Sorry For" "Even the name of the place - Nabua - is rich in exotic suggestion; already creating the image of a jungle at night (hot and wet from the fresh summer rain) before the film has even begun. The lightning storm that introduces the film - real or man-made - also sets a tone for the experiments to follow. Already we're seeing the contrast between the natural and the artificial - both the differences and the similarities - in two distinct presentations; like the two layers of projection from which the film is made - an artificial recording of a literal projection of light on a canvas, capturing another artificial recording against the backdrop of a jungle at night." Linden Arden, Lights in the Dusk, "Phantoms of Nabua" "Craig's newest, Eggs-in-a-Basket, opens with the pounding, adamantine rhythms of an egg-beater. In pop terms, this betrays the subtleties of scrambling (as well the profundities of Brian De Palma's Slash-'n'-Egg masterpiece) for the shallowness of Hollywood excitation. How did Steven Spielberg miss out on such a project? Eggs-in-a-Basket condenses food groups that most breakfasts usually ignore. Problem is, Craig doesn’t establish credible plate atmosphere (just a stupidly stylized slo-mo gravy montage). Craig's kitchen resembles the 3-D, sci-fi HQ in "Déjà Vu" with coworkers joshing each other like beer commercial frat house boys: Cheap shorthand for working-class tolerance." -Craig, The Man from Porlock, "Armond White Reviews My Breakfast" "Modleski basically attempts to stand between the polar opposition of perspectives on Hitchcock’s view of women – that he was a misogynist (Mulvey) or that he was a proto-feminist (Wood.) She humorously undercuts Wood’s wish to “save” Hitchcock for feminism as auteurist romanticism, making it clear that her intention is to “save” feminism for film studies (or vice-versa.) She achieves this through the close study of Hitchcock’s position on women in seven films. Modleski terms Hitch “ambivalent” about women and – similarly to Truffaut above - suggests that his talent, and more importantly his value for a feminist “reader” of his films, comes from the clarity of his expression of his anxieties about women. " Ben, Man Without a Star, "Reading the Movies: Some Books for Cinephiles!" "There is one sequence in a spaceship where the characters dance to Van Halen's "Dance the Night Away", and the camera is as weightless as the characters. Even if you don't like the movie I defy you (seriously) to tell me that this sequence, at once romantic and bittersweet (romantic in that it shows how in love the Robbins character is with his wife, bittersweet in that it highlights the loss felt by the Sinise character), doesn't at least bring a smile to your face. The sequence that shows the Mars Rover exploring the Mars Terrain (one that recalls R2-D2's arrival on Tattoine from Star Wars), with Ennio Morricone's soothing, beautiful music on the soundtrack, uncannily recreates the surface of Mars in gorgeous widescreen. Brian De Palma has always been a film maker who operated within the Hollywood system, all the while subverting it within his films, and it speaks to what an idiosyncratic artist he is that he managed to bring his unique moral stamp to a large-scale Hollywood spectacle." -Ryan Kelly, Medfly Quarantine, "Visions of Life: Mission to Mars" "I've always thought there was something fascinating about Marilyn Chambers. For many she will remain just infamous, but for me she's eternally captivating. Her work in Rabid alone will always remain special to me. It's the kind of wonderfully naive and fresh performances that a more 'accomplished' actor could never even hope to give. The fact that it should have led to more 'legitimate' work for Chambers is unquestionable but honestly, no matter which path she chose to travel in her life, Marilyn Chambers was always legitimate." -Jeremy Richey, Moon in the Gutter, "Cinema's Great Faces: Marilyn Chambers in David Cronenberg's Rabid" "Tarr's seemingly endless takes, his extreme patience for letting a scene's natural rhythms play out — a static view held for an uncomfortably long time, a camera that creeps in a slow sideways pan to reveal the blank expanse lurking around the corner, the way that characters step out of a shot only to be picked up again, long minutes later, when the camera's slow glide finally catches up to them somewhere else — encourage a depth of focus and concentration on the material reality onscreen. This is not always true of Tarkovsky, who despite the superficial similarity in aesthetics was often reaching for something beyond the surface image, but it often is the case with Antonioni, who saw truth and beauty and depth, paradoxically, in surfaces and appearances." -Ed Howard, Only the Cinema, "Damnation" "The first David Lynch film I saw was Mulholland Drive in late 2001. I don’t know why it was playing where it was playing, or why I went to see it instead of something a little more usual, but it was the happiest accident I have ever been a part of." "Whether through transcendental meditation or his constant diet of cigarettes and coffee, somehow Lynch has acquired an uncanny knack for visually and aurally divining the power and beauty of images and scenarios in a way that defies the reductive task of analysis or explication." "David Lynch’s commercial work infuses a vulgar, materialist medium with an aesthetic and cultural significance that, at times, goes against the foundation of consumerist culture." "If anything, I usually come up with a new theory every few viewings based on what I emphasized during the film (this time’s emphasis was circular shapes and characters being submerged into liquids)." -James Hansen, Brandon Colvin, Chuck Williamson, Jason Shoaf, Out 1, "David Lynch week" (a page of all the posts that went up during their 7-day tribute to the director) Contains some graphic images and language: (accompanied by essay) -Andreas, Pussy Goes Grrr, "An Alternative History of American Film" "At the time, Gould was box office poison in Hollywood after his rumored troubles on the set of A Glimpse of Tiger where he argued with co-star Kim Darby, exchanged blows with director Anthony Harvey, and abused drugs as well as being unreliable and absent. Warner Bros. stopped the production early on and Gould claimed that he was blamed for its failure. The studio collected on an insurance policy that attested the actor was crazy. For The Long Goodbye, United Artists gave Gould the requisite physical before approving his contract and demanded a psychological exam to determine that the actor was mentally stable. " -J.D., Radiator Heaven, "The Long Goodbye" "And while listing to “Wishing Well” I thought of Edvard Munch and his primal shrieks, the interconnected nature of art and life and life as art, that blood-red sky hanging over “The Scream”, the model for Munch’s “Madonna” who was later shot dead through the head by a mad Russian lover, that innocent kiss on the back of the neck that inspired his “Vampire”, the mad women from Bergman’s Cries and Whispers, and well, that well that Rex Thomas Gail fell down in his dreams in my own novel The Thief Maker, and that botemless well that haunted my nightmares until Paul Thomas Anderson revealed to me what was at the bottom in There Will Be Blood. Well…what is at the bottom? A Scream? Oil? A Canvas? Ambition? Love? Despair? Art? Part of the beauty and mystery of life is figuring it out for yourself…" -David H. Schleicher, The Schleicher Spin, "Well If You Must Scream" "But I love the speech. It raises my pulse, and it makes me proud to love Chaplin. When the end of the film comes, Chaplin, as he did with the romance of The Gold Rush and City Lights, manages to convince me to turn off all the centers of my brain that deal with logic and the intricacies of filmmaking. When he takes that stage, confused to be Hynkel, he gives us a version of the world as it could be, and that bypasses my brain and speaks to my heart. Although I've read a tremendous amount of criticism against it, I've never read a proposal that moves me even a fraction of how Chaplin can." -T.S., Screen Savour, "The Great Dictator (1940)" "And one Saturday, sometime in 1990, if I’m not mistaken, engulfed by bills and not making nearly enough at my graveyard shift job to exist at a level that didn’t in one way or another embarrass me in front of friends and family, Patty and I had made plans to spend some time together. I knew that I didn’t have the means to take her out the way I knew I wanted to, and I wanted to mask from her the fact that I was as poor as house dust for as long as I could—God forbid she have all the facts and use them to decide one way or the other (probably the other) as to the wisdom of spending much more time with me. I’d already sold just about every CD, essential and nonessential, that I had, as well as every book that held any value for me or anyone else, so my meager resources were extra meager. There was, however, something on my shelf that might fetch enough pretty pennies to get us through the weekend, and I was committed enough to pursuing the relationship that, after only a minor session of hand-wringing, hemming and/or hawing, I swallowed hard and decided that, in order to get the money to take Patty out on the town that night, I would gather up my 12 years of John Willis’ Screen World volumes off the shelf and see if anyone in town was willing to pay me for them." -Dennis Cozzalio, Sergio Leone and the Infield Fly Rule, "PRINT, THE LEGEND: THE TRUE STORY OF MY LIFE WITH JOHN WILLIS' SCREEN WORLD" "Repulsion fittingly begins with a zoom out of Carol’s eye and ends with a zoom into it, preparing us for the purely subjective tale that takes place between these two shots (and also paying homage to the surreal masterpiece Un Chien Andalou (1929) which, too, slit the human eye to look beyond its retina). The movie is entirely seen through Carol’s eyes and faithful reproduction of reality is flushed down the drain. Anything is possible within these two goal posts. None of the events that we witness might have happened in reality, but they sure do in Carol’s mind." -Just Another Film Buff, The Seventh Art, "Flashback #69" -Shanh, Six martinis and the seventh art, "Prisoner 13" "Researching this piece, I noticed that, with the exception of Peranson's Joseph, all of the characters played by the critics are of vexatious, unpleasant, and/or just downright villanous bearing. I can't imagine why this is the case." -Glenn Kenny, Some Came Running, "When Film Critics Act: A Selective Survey" "The first Martin Scorsese film I ever saw was “Who That Knocking at My Door” back in September 1969 at the Carnegie Hall Cinema, a movie theater located beneath the famed Carnegie Hall. At the time, the theatre showed mostly art house, foreign, independent and classic films. I was home on leave from the Army, having just completed Basic Training and AIT, trying to avoid thinking about where I was going to be next month (Vietnam) by losing myself in as many movies as I could. And if you want to lose yourself in movies, New York City is the best place to be other than maybe Paris." -John Greco, 24 Frames, "Mean Streets (1973) Martin Scorsese" "This thrilling journey and tragic love story is easily one of 2009's best films. It is already getting compared to films like 2002's Cidade de Deus (City of God). It might not be on the same level of Cidade de Deus, but it is definitely a must-watch film for 2009. Many people in the mainstream audiences probably do not know that this gem of a film even exists, but anyone who stumbles across this film will probably be left breathless by the end as they witness truly raw and powerful film-making." -Zach, Unfettered Tastes, "Sin Nombre" "We are still seeing that which masses of people, from all walks of life, are seeing and we all have our own favourite images from the great films of cinema imprinted on the mind’s eye for the term of our natural lives. For myself, I can recall such screen memories as the look of recognition in front of the traffic lights from Anton Walbrook in The Life and Death of Colonel Blimp as Deborah Kerr’s face is lit up for him; the look on the face of the dying King Kong; Chieko Higashiyama and Chishu Ryu staring out to sea in Tokyo Story; Orson Welles dripping evil in the shadows in The Third Man; the immortal fade out to Modern Times; Errol Flynn entering the great hall of Nottingham Castle with his deer in The Adventures of Robin Hood; Bill Murray’s inaudible farewell to Scarlett Johansson in Lost in Translation; Josephine Stuart staggering along the dirt track at the beginning of Lean’s Oliver Twist; Karloff’s monster with the little girl in Frankenstein; the smile that creeps across Shirley MacLaine’s face during Auld Lang Syne in The Apartment; Herbert Marshall ordering dinner in Trouble in Paradise; the mirror sequence in Duck Soup; Falconetti tied to the stake in La Passion de Jeanne d’Arc; Malcolm McDowell doling out punishment to his droogs along the embankment at Thamesmead in A Clockwork Orange; Liv Ullmann and Bibi Andersson’s faces becoming one in Persona; Everett Sloane’s New Jersey ferry speech in Citizen Kane [...]" -Allan Fish, Wonders in the Dark, "Introduction from my book 'The Untouchables'" So there it is. But, of course, there's not all. As an addenda, let me first highlight a bit more of my own work. Particular favorites are asterisked - and I should mention that the Obama piece, written in the wake of my attendance at his inauguration, is worth reading for historical resonance if nothing else. Following these selections are the rest of the posts nominated by the bloggers above - I only chose one each for the final selection, but in some cases it was quite arbitrary so please do browse the links below. You may end up liking them even more than what I picked. Here are some more pieces I can live with digging up again: Antichrist • Apocalypse Now Redux • The Baader-Meinhof Complex • Capturing the Friedmans • A Charlie Brown Christmas & It's Christmastime Again, Charlie Brown! • Farewell, Updike • (500) Days of Summer • Flight of the Red Balloon • For the Love of Movies • For the Love of Movies: Interview with director and critic Gerald Peary • Funny Ha Ha • The Girlfriend Experience • Gone With the Wind • The Great Movies • Greetings • Grizzly Man • Historias Extraordinarias • Jaws • Just because you are a character, doesn't mean you have character... • The Lost Weekend • My Brother is an Only Child • Obama: Premonitions of a new epoch • Le Petit Soldat • Pirate Radio • The Red Balloon • Rocco & His Brothers • Roman Polanski: Wanted and Desired • To Kill a Mockingbird • 2001: A Space Odyssey • The Wild Bunch • **The Wind in the Willows • "The Wind in the Willows: 'The Piper at the Gates of Dawn' and 'Wayfarers, All'". And here are my fellow bloggers' other self-nominations: (Another Old Movie Blog) Ladies of Noir 1, 2, 3 • Picnic at Peyton Place 1, 2, 3 (Are the hills going to march off?) Still Walking • Eraserhead • There Will Be Blood • WR: Mysteries of the Organism. (Aspiring Sellout) A Book Review of David Thomson's "Have You Seen...?" • An Atheist's Guide to the Legend of Sleepy Hollow • My One Horse Town Libido is an Abandoned Miniature Golf Course (Checking on My Sausages) Revenge of the Sith • Public Enemies (Cinema Styles) The Wanderers: James Edwards • And they had Jazzercise (The Cooler) A Film of a Few Words: Hunger (The Dark of the Matinee) Back in Time: Movie Period Meme (Elusive Lucidity) The Lives of Others • Inglourious Basterds (The Elusive Robert Denby) Night of the Hunter review • Top 10 movies of 2008 • Lolita (Eternal Sunshine of the Logical Mind) Misunderstood Genius or Spectacular Failure? • The Yakuza Papers • L'Enfer D'Henri-Georges Clouzot (Ferdy on Films, etc.) (Marilyn) Sea of Love • Cloverfield • The Prime of Miss Jean Brodie • The Spirit of Ed Wood Blogathon: Babes in Arms • Count Dracula • The Bridge • Gabriel Over the White House • Lady Vengeance • Twenty-five Essential Documentaries of the 2000s (Roderick) Vampyros Lesbos (1970) • Martin (1977), Twilight (2008) • Branded to Kill (1967) • Hunger (2008) • Kaidan/Kwaidan (1964) • Kill Bill Vol. 1 (2003), Vol. 2 (2004) • Zu Warriors from the Magic Mountain (1983) • Broken Blossoms (1919) • Ryan's Daughter (1970) • Bonjour Tristesse (1958) • Deep Red/Profondo Rosso (1975) • Eyes Wide Shut (1999) • The 400 Blows/Les Quatre Cents Coups (1959) • CQ (2001) • Twenty Five Essential Films of the 2000s (The Film Doctor) Public Enemies • notes on Fantastic Mr. Fox • Land of the Lost (The Filmist) Children of Men • There Will Be Blood • The Fall • Che: Part One/The Argentine • No Country for Old Men • The Hurt Locker • Oldboy • The Lord of the Rings • The Dark Knight (Film Noir) The Lost Weekend (1945): “I can’t take quiet desperation” • Christ in Concrete (1949): Simply a masterpiece • Caged (1950): “the plot of our life sweats in the dark like a face” • I Wake Up Screaming (1941): Bizarre Transference • Le quai des brumes (Port of Shadows – France 1938): Poetic Realism (Final Cut) my feature on Chinese cinema • financing the film industry • a profile of Kate Hudson • the future of indie movies • a profile of Will Smith (Goodfellas Movie Blog) Angels With Dirty Faces • JFK • The Assassination of Jesse James by the Coward Robert Ford (Greenbriar Pictures Show) When the Passion Seems Yours Alone • Two Gun Square Deal Man • King Konv versus Godzilla • The Peter Pan War (Icebox Movies) Saving Private Ryan (1998) • Quintet (1979) • Edvard Munch (1974) • Land of the Pharaohs (1955) • The Many Adventures of Winnie the Pooh (1977) (Lazy Eye Theatre) Get Your Vulcan Kink On • Movie Confessions (Lights in the Dusk) Tropical Malady • Alphaville • Seed (The Man From Porlock) Geek Orthodox: Musings on the Unholy Trinity of Filmmakers, Their Critics and Their Fans • Why We Film (Inglourious Basterds) • Fight the Future (Avatar and Southland Tales) • Waxing on Nostalgia: The Karate Kid (Medfly Quarantine) Tetro • Inglourious Basterds • Armond White controversy. (Moon in the Gutter) Sam Peckinpah's Forgotten Masterpiece • Adventureland: Ballad of El Goodo (Only the Cinema) Black Book • A Girl in Every Port • The Conversations: Michael Mann (with Jason Bellamy) (Pussy Goes Grrr) Black Holes and Alien Bodies • My Favorite Movies: Sherlock, Jr. • Happy Holidays: A Visit to the Mall (Radiator Heaven) Dead Men Don't Wear Plaid • The Game • So I Married an Axe Murderer • The Long Goodbye • The Good, The Bad and the Ugly (The Schliecher Spin) The Best Screenplays of All Time • A Review of Toni Morrison's A Mercy (Screen Savour) Vertigo (1958) • North by Northwest (1959) • Psycho (1960) • The Birth of a Nation (1915) • Metropolis (1927) • Sherlock Jr. (1924) • The General (1927) (Sergio Leone and the Infield Fly Rule) A Letter to Rian Johnson • Friday the 13th 2009: The Slash remains the Same • Print, the Legend: The True Story of My Life with John Willis' Screen World • Revisiting Sam Peckinpah's Convoy • The Anna May Wong Story • Duck Soup: Funniest Movie Ever? • On The Hangover, land of the Lost and Pelham Redux • Grindhouse Report • Michael Jackson and Farrah Fawcett • Stephanie Zacharek • Joe Dante • Inglourious Basterds Part 1, 2, 3, 4 (The Seventh Art) The films of Artavazd Peleshian (Six Martinis and the Seventh Art) El Prisionero 13 • Line and Shape • Pearls and Lace • the sixth in the Light Flare series (24 Frames) THE STEEL HELMET • THE KILLING • The Tall T • FEMME FATALE - GLORIA GRAHAME (Unfettered Tastes) Sugar Review If you haven't had enough yet, in the past year I assembled directories for all my work on the The Dancing Image and also elsewhere. And finally, here's the round-up for 2008. Thanks to all who have participated. Share your thoughts and responses below - comments are now moderated on this blog due to spam, and I am away from my computer for much of each day, but I will try to update the comment flow as frequently as possible. Thanks again - and enjoy! Labels: blog year, images Andrew K. said... So much to read, but of those I read it's cool that The Mad Hatter's chosen post was my favourite post of his last year. Good work compiling this movieman. Troy Olson said... Holy crap, Joel. I haven't actually read the post yet, but the sheer amount of work that must have gone into it is quite impressive (and a great tribute to all of the bloggers involved). Well done. Just Another Film Buff said... This is amazing stuff, Joel. it's really nice to see good cinema being supported by so many people, across teh globe, with such enthusiasm. And this round-up brings together all those wonderful moments the authors may have had watching those films. Another thumbs up from my side for those beautiful writers and readers at Wonders in the Dark, especially Sam Juliano and Allan Fish. Thanks for this. I'm going to be occupied for a long time to come. Joel Bocko said... Thanks, guys. Andrew, your post has been added. Wow, this is fantastic. I have read some of these pieces and look forward to giving them all my full attention. I'm proud to be amongst so much good and interesting writing. Thanks for the time and effort MovieMan. Thanks for this post, the links, and this window into the work of some terrific bloggers. Thanks for the inclusion/shout-out! It really means a lot to me coming from a blogger I admire greatly. Wow, so many links/posts to check out. This is great and a fantastic way to bring all these blogs together. Carson Lund said... I really appreciate being included in this excellent list. It's a great way of bringing together all of the wonderful work done around the blogosphere. On another note, MovieMan, I see you write for the Boston Examiner. I've read your work for a while now, unaware though that it was you writing it. I also live in Boston; it's great to see fellow enthusiastic bloggers from where I live! Tony Dayoub said... Thanks for the acknowledgement, Joel. I would not have picked that piece as my favorite, so it just goes to show you how one's ability to judge their own work can be somewhat skewed. It will take me a while to digest all of this, but I look forward to it. Stephen, Jacqueline, JD., thank you guys for your enthusiasm and also for the pieces which I linked up. I hope you guys keep coming back and digging - there's a lot of great stuff here, much of which I discovered for the first time while linking it! Actually I'd love if you nominated another post that I could include in the body of my line-up (the update at top will let returning readers know there's a new addition). The shout-outs to you, Sam, and Ibetolis were not meant to preclude your own pick, merely to pay extra tribute - it would be great to see your own personal choice for #1! That said, I really did love that piece; sometimes there's an essay that really brings together the different threads of a writer's personality and style, and I thought this one did that for you. And thanks again for posting my video in the first place. I do hope a few people will check it out, despite its NSFW warning & the tendency to skip over videos in the fast-paced perusal of blogs, something I often tend to do myself, despite usually loving them once I settle in to watch. In some ways, it's my favorite work of the year: it took the most time to put together out of anything I did, it allowed to flex a muscle I haven't flexed in a while (and I actually tend to value my editing capabilities over my writing at times), and was different from a lot of what's out there. But I'm not sure many people caught it the first time around. Or else they did, didn't care for it, and were too nice to say! Either way, I was very happy with how it turned out. Carson, that's great to hear. I frankly didn't think I had any regular readers on the Examiner, except those who came through either my blogging work or the links at Wonders (which maybe you came through too, though the fact that you're a Bostoner may belie that). Good to know it has some draw of its own! I hope to get back to work there soon but am waiting for word back on some ideas of mine, which is unfortunately taking its slow time. I'll nominate one: "The Gimp" and Its Implications on Contemporary Cinema As far as your video for the De Palma Blog-a-Thon, it really got a lot of traffic, so I think it was fairly well-received. I know I enjoyed it, and I encourage all of your readers to check it out. A few quick corrections: sorry, Sam, for referring to you as "her" & Tony for writing "unwieldy" rather than "never unwieldy". Both mistakes have been fixed. Tony, your link has been added. Also, in case anyone is wondering the post went up on the 6th, but the date reads "January 8" because it was originally categorized on the date the post was initiated, back in December. I fixed it this afternoon. James Hansen said... Very cool (and very sorry I didn't get around to participating this year)! Damn schedules have killed us this fall, but plenty more coming in 2010! Good work. James, jump right in now! I'll be adding submissions as they come, and hopefully you won't be the last. Respond either here or at Sun's Not Yellow, and I'll add the link and put an update at the top of the post. Same goes for the rest of the gang at Out 1 too, of course. Sam Juliano said... I am late to the party here Joel, but in behalf of Allan and the crew at Wonders I want to thank you exceedingly for this extraordinary red carpet treatment, for the posting of the one writing I am most proud of as its dearest to my heart, and to the incredible kindness, so eloquently expressed. Converesely our site has benefited by your own impeccably written essays, befitting one of the blogosphere's finest writers. This is the mother of all posts as as it's author I salute you both in accomplishment and more importantly in friendship. My God what a thorough post. My blogroll might explode once I finish crawling through all these links. What a lovely way of honoring some of the best writers out there. For Out 1, I would nominate our David Lynch week from way back in January 09. Early in the year, but shouldn't be forgotten! After realizing none of us had written on one of our favorite filmmakers, we decided to write about Lynch all week. There's a great range of articles that are passionately written, well argued, and fun to read (hopefully). Great post here. Glad to see so much enthusiasm for the work being done around the internet. http://www.out1filmjournal.com/search/label/David%20Lynch Dennis Cozzalio said... Hi, Joel! This is an incredible feat you've achieved here! I am really looking forward to printing this out and taking it all in at my own pace. As for my own submission, I am dreadfully late, I know, but I'd like to send something your way. I just can't seem to find your e-mail address. Hey, no problem Dennis - glad to have you on board! My e-mail is movieman0283@gmail.com, but feel free to drop a suggestion her or over at The Sun's Not Yellow as well - whatever's most convenient for you. Happy new year! filmgeek said... Great collection. I think the quote from my entry explains why this post is so interesting and vital to film blogging Thanks, filmgeek. I agree with you on the quote - that's, in part, why I chose it. Also, the font color scheme adds a little color to the line-up! Joseph "Jon" Lanthier said... Phenomenal choices, Joel, including my own piece on "3 Women". Lots of great stuff here to catch up on; your diligence in the film blogosphere is truly an inspiration. Sorry I'm only catching this now... No problem, Jon - catch-up is good! I'd rather that than having stuff slip away if it isn't caught right away - and that was kind of the motivating spirit behind this post in the first place.	cc/2020-05/en_middle_0111.json.gz/line2755
__label__cc	0.709334	0.290666	LotPro.com is owned and operated by MH Sub I, LLC dba Auto Credit Express. The company has deep roots in the retail automotive community. The owners and employees of ACE have been helping consumers and auto dealers expedite the car buying process since 1992. Our partnerships with the most trustworthy and high-volume dealers across the country enable us to provide fast, accurate price quotes for brand new or used cars. We strive to "get it right the first time." Time is precious and we value yours. In February of 2003, ACE purchased Alternative Resources and Training, creators of the "Inventory Manager," a software program used by auto dealers to manage their new and used vehicle inventory. Prior to its national release, the software was renamed LotPro®. Today the software is used by hundreds of dealers throughout the USA. As an extension of the software, this website was established to give consumers an elevated level of website form and functionality. It is our goal to provide consumers with accurate data and a highly functional, yet fast browsing experience. To accomplish this, we have assembled a team of the nation's top internet developers and automotive consultants. Visit the Lotpro Library Toyota Incentives for February 2012 Another month, another chance to talk about Toyota incentives. February incentives for Toyota aren't the largest around this month, especially if you have your heart set on big cash rebates. Still there are a number of deals and.... Used Car Price Values Rising Statistics from our used car search engine indicate that prices and used car values are on the rise, especially for Nissan used cars and 30 mpg used cars. A good alternative may be new cars for sale with high gas.... Used Car Search Locations - Lotpro Review 30 Each week we review our server logs to determine where the most popular places to buy used cars are from month to month. This month used car shopping heats up out west, the northeast stumbles, and the south soldiers.... Ford Transit Connect Brings 22 City 25 Highway MPG to Market-Leading Commercial Truck Ford Transit Connect is a purpose-built commercial vehicle, built on a dedicated commercial vehicle platform in an exclusive commercial vehicle production facility. It is designed, engineered and manufactured by Ford of Europe to beat tough, light commerc.... 2019 Mazda Mazda3 Hatchback Premium AWD Driving Impressions The all-new 2019 Mazda Mazda3 hatchback impresses with a stunning interior, improved ride comfort, optional all-wheel-drive, solid fuel economy figures, and a number of advanced safety features. However, we continue to be disappointed by the tight rear seat, a polarizing design that limits driver visibility from the B-pillar on back, a watered-down driving character and, despite improved software, a needlessly complex infotainment system. 2019 Genesis G90 3.3T Premium Driving Impressions Unchanged from last year, the 2019 Genesis G90 sits atop the brand’s lineup, offering luxury buyers a sumptuous interior, cosseting ride, and an abundance of standard features. But it continues to disappoint with an innocuous design, a V-8 that doesn’t reward the extra shekels, and a wing medallion that still lacks the prestige of the roundel and three-pointed star. 2019 Volvo XC60 T8 e-AWD R-Design Driving Impressions All-new last year, the 2019 Volvo XC60 T8 E-AWD carries on with a lovely, subdued design, stunning, versatile cabin, silky ride, and a fuel-efficient drivetrain that features eight-speed automatic. But options elevate the price quickly, premium fuel is required, while the semi-autonomous Pilot Assist system still needs some work. 2019 Hyundai Elantra Sport Driving Impressions Mid-cycle updates including the addition of standard advanced safety features keep the 2019 Hyundai Elantra Sport fresh, while the 2.0-liter turbo and fully-independent suspension make for entertaining daily drives. But all is not perfect, as pedal feel and steering feedback could be better, while the 6-speed manual will not be offered next year. data-ad-slot="5147846490" data-ad-format="auto"> Copyright © 2005 - 2020 MH Sub I, LLC dba Auto Credit Express and its licensors. All rights reserved. By using this site, you agree to be bound by our Terms Use, Privacy Policy, Supplemental Terms, and Cookie Policy Do Not Sell My Personal Information	cc/2020-05/en_middle_0111.json.gz/line2756
__label__wiki	0.712752	0.712752	6916 Blanding Boulevard Directions Jacksonville, FL 32244 Mazda Comparisons What is SkyActiv Certified Mazda Vehicles Get Instant Trade-in Offer First Time Owners Mazda Military Bonus Shop Mazda Accessories Shop Mazda Tires Hablamos Espanol! Directions from Middleburg, FL Directions from Saint Augustine Structure My Deal tools are complete — you're ready to visit Mazda City of Orange Park! Done with the tools you need? You're ready to visit Mazda City of Orange Park! Get Driving Directions Giving Back to the Jacksonville Community Mazda City of Orange Park 6916 Blanding Boulevard Mazda City of Orange Park Gives Back to the Community While many people know that when they're looking for a quality new Mazda vehicle around the Jacksonville area that we're the place to come find it, what they might not know is that our goal isn't just to sell you a new or used vehicle, and provide service and maintenance, it's to be a good member of the areas where we live too. It's why our involvement in the community is strong and let's us show that we're your neighborhood dealership that's willing to lend a helping hand, whether it's putting on events and sponsoring them, or donating our time to worthy causes, we're here to help make our community a better place to live. As part of the Tom Bush Family of Dealerships, which have been serving the Jacksonville area since 1970 and our particular dealership has been here since 1989, and not only have we provided folks with plenty of cars in that time, but we're also out making sure that when those in need could use help, or if there's any way we can make our community better, we're doing it. Couple this with our commitment to giving you the best customer service experience possible and it's just one of the many reasons to shop here at Mazda City Orange Park. We Volunteer Our Time and Efforts to Many Good Causes Around Jacksonville Whether it's Jacksonville, Saint Augustine, Middleburg, or Gainesville we make sure that we get involved in good works any way we can. That includes: Breast Cancer Awareness and Prevention Month where we support related organizations to help research and fund a cure. It's a personal thing for us as many, including our founder's late wife Laura Bush, are breast cancer survivors or have been impacted by it. We do this all throughout October and wear pink on Thursdays. The Mister Rogers' Neighborhood Sweater Drive is an event we participate in every year joining WJCT, VyStar Credit Union and Two Men and a Truck which helps provide warmed for those who need it during the holiday season and the colder months of the year here in Jacksonville. We also support Mission House: Compassion by the Sea, which is a fundraiser to help the homeless in our community on the streets and beaches of Jacksonville find affordable and permanent housing. Over the last two years, they've helped over 100 people and will hopefully provide more with the right housing and care that they need with our help. We also provide plenty of sponsorship whether it's the Jacksonville Veteran's Memorial Arena or Whale of the Sale: Junior League of Jacksonville, we lend our support to community landmarks and events that bring everyone together for a good time. Learn More About Our Community Involvement here at Mazda City Orange Park Today If you'd like to know more about our community works here in the Jacksonville area, or have an event you think we'd be interested in sponsoring, contact us today. Our team will get back to you as soon as possible and discuss and provide support for events in and around the area that enrich our community and put a smile on people's faces! Jacksonville, FL 32244	cc/2020-05/en_middle_0111.json.gz/line2762
__label__wiki	0.954375	0.954375	Black executive handcuffed in own driveway wins in court after state trooper a no-show By Mensah M. Dean A screen shot from the dashcam video of a Pennsylvania state trooper shows the arrest of Rodney Gillespie in his driveway of his Chadds Ford home. (Pennsylvania State Police) Rodney Gillespie, an African-American pharmaceutical executive who accused a Pennsylvania state trooper of racial profiling after a July traffic stop in which he was handcuffed in the driveway of his Chadds Ford home, had a happy 53rd birthday Tuesday. A charge against Gillespie of failing to drive within a single lane was dismissed by Delaware County Judge Judge Kathrynann W. Durham after the arresting officer, Trooper Christopher Johnson, failed to show up for the trial in Media. “I had my video evidence ready to show the judge, and Rodney was there and ready, and the cop never showed up, no explanation,” said Gillespie's attorney, Michael Quinn. Ryan Tarkowski, a spokesperson for the state police, did not respond to a call for comment Tuesday afternoon. Gillespie, an executive with AstraZeneca, said he now intends to file a lawsuit. “I'm hopeful that this type of action will help prevent this from happening to other innocent members of society, and especially people of color,” he said. [More News] Man killed Quakertown roommate with baseball bat 16 years ago, then ‘assumed his life,’ DA says » A 25-minute police dashcam video of the 1 a.m. July 8 incident was made public in September when an internal state police probe cleared Johnson of racial bias against Gillespie. The investigation also concluded that troopers on the scene violated two departmental regulations during the traffic stop. The video starts shortly before the left tires of Gillespie's rented Jeep Grand Cherokee Laredo touch the yellow lines of a road that intersects with the street where his family lives, but does not show when Johnson and his partner began following the Jeep on Baltimore Pike. The trooper activates his flashing lights after the tires touch the yellow lines. Gillespie contends that the troopers had no reason to follow the Jeep he was driving with his wife, Angela, and their teenage daughter as passengers, returning from a visit with relatives in Lambertville, N.J. “I think I was completely targeted,” he told The Inquirer in August. “This is a very nice, affluent neighborhood. A black guy driving. I guess he thought I was driving by myself, and he wanted to follow and see.” [More News] Woman steals car during drug deal, crashes it into Bethlehem home, police say » During the encounter, Gillespie was handcuffed and rebuked by Johnson for saying he had not pulled his vehicle over immediately when the trooper turned on his lights and siren because he feared being shot on the unlighted road. He stopped when he got to his well-lighted driveway. Gillespie and his wife had returned to the Philadelphia area the week before after living for six years in London and Johannesburg for his job. “To be welcomed back this way just didn't make sense,” Angela Gillespie said in August. “This is not the America we left in 2013. We've come back to an elevated rage.” Gillespie initially pleaded guilty to the traffic violation, but that conviction was vacated, and a second charge for failing to immediately stop was dismissed. Most Read • Pennsylvania News Pat Toomey’s Senate ‘candy desk’ may prevent hangry lawmakers during impeachment	cc/2020-05/en_middle_0111.json.gz/line2763
__label__wiki	0.522141	0.522141	Passer au contenu directement. Le présent site Web utilise des témoins à diverses fins afin de nous permettre de mieux comprendre vos intérêts et d’améliorer le site. En utilisant notre site Web, vous reconnaissez que nous recourons à des témoins essentiels et vous consentez à l’utilisation de témoins non essentiels, comme l’explique notre Politique sur les témoins. Pour mieux comprendre comment nous utilisons les témoins ou pour modifier vos préférences et les paramètres pertinents de votre navigateur, veuillez consulter notre Politique sur les témoins btn_open_menu btn_close_menu Inclusion et responsibilité sociale Références et séminaires btn_search_global Retour à la section TechLex Voir les options de partage Partager sur Facebook Partager sur Twitter Partager sur LinkedIn Partager sur Google+ Partager par courriel Rester connecté par RSS Imprimer la page courante Sophie Gupta Filtrer par auteur Filtrer par auteur Sophie Gupta Filtrer par sujet Filtrer par sujet Vie privée Médias sociaux Filtrer par service Filtrer par service Technologie Défiler vers Article Défiler vers Auteurs Défiler vers Publications This past October, the European Parliament’s Committee on Civil Liberties, Justice and Home Affaires (“LIBE”) voted in favour of a major reform of the current European Union (“EU”) data protection regime consisting of the Data Protection Directive, introduced in 1995, and national legislative works existing across EU member states. Intended as a response to privacy concerns in respect of technological developments and recent cases involving mass surveillance, LIBE adopted a proposed General Data Protection Regulation (the “Regulation”), which, once in force, would not only represent a major change in the protection of personal information within the boundaries of the EU but which could extend to and impact Canadian businesses. Features of the General Data Protection Regulation The right to be forgotten, or the “right to erasure” as it has more recently been dubbed, allows individuals to require the deletion of their digital trace, that is, any personal data relating to them, and that there is no further dissemination of such data. Individuals may demand erasure “where the retention of such [personal] data is not in compliance” with the Regulation, including where the data is no longer necessary for the purpose it was collected, where the individual concerned has withdrawn consent, or simply, and perhaps most importantly, because the individual objects to the processing, use or disclosure of their personal data. These requests extend not only to companies collecting personal information but also to third-party internet or cloud hosting companies to whom data may have been transferred. While the extent and scope of the Regulation is still unclear, it is likely to be particularly onerous on internet service providers and major search engine, cloud and social-media companies like Google, Facebook, LinkedIn and YouTube, due to the amount of personal data processed on these platforms. The Regulation also includes stronger safeguards for data transfers to non-EU countries, such that if a court or administrative authority of a third-party country asks a company to divulge personal information processed or controlled in the EU, such request must be approved by the supervisory authority before any data may be transferred. Furthermore, the company transferring the requested data would have an additional obligation to notify the person concerned prior to any such transfer. EU-based multinational corporations that, by the very nature of their business, regularly transfer data outside of the EU, be it to other branches, affiliates or subsidiaries, including cloud service providers, may benefit from an exception to the data transfer restrictions limiting transmission to “white list countries”, as determined by the Commission. Such exceptions are granted where both the EU-based data controller or processing company and the non-EU recipient company, or respective branches of same, have successfully obtained a European Data Protection Seal issued by any supervisory authority in the EU following the audit and certification of their data processing activities. The EU Data Protection Seal is valid for five years and provides additional incentives to certified companies, including an exemption from fines for non-compliance in the absence of intentional or negligent conduct. As it currently stands, both Canada and the US are members of the EU “white-list” and deemed to be countries having an adequate level of data protection by reason of their domestic law or international commitments. The issue of how consent may be given remains the subject of much debate as, in its current draft, the Regulation requires that consent be free, specific, informed and explicit, thus raising concerns for companies whose existing business models do not always allow for express consent to be obtained and which rely on the general application that consent to the collection, use and disclosure of personal data may be implicitly given or inferred in prescribed situations. How this matter will be resolved and reflected in the final draft of the Regulation could bring with it the obligation for some companies to re-evaluate how they conduct certain business activities. The Regulation also requires that consent be freely given, thereby prohibiting that the execution of a contract or provision of service be made conditional upon the receipt of consent to data processing, except where such consent is necessary or inherently connected to the contract or service. Moreover, individuals have the right to withdraw their consent at any time. Companies failing to comply with the Regulation could, as the proposed text of the Regulation currently reads, face fines of up to €100 million or 5% of worldwide annual turnover, whichever is greater, thereby pushing the risk of exposure to such extensive financial sanctions to the top of the priority list of compliance matters. Also proposed, are certain alternate or additional sanctions, including regular audits of data processing and compliance measures and written warnings for unintentional, non-negligent, first offences. Personal Data Protection in Canada In Canada, the collection, use and disclosure of personal information is regulated concurrently by the federal and provincial governments. At the federal level, two statutes exist to govern privacy issues, the Privacy Act, which regulates federal government departments and agencies, and the Personal Information Protection and Electronic Documents Act (“PIPEDA”), which sets out how private sector organizations may collect, use or disclose personal information of individuals in the course of their commercial activities. At the provincial level, each of the provinces and territories has privacy legislation the governs the collection, use and disclosure of personal information held by government agencies, however, British Columbia, Alberta and Quebec, and most recently, Manitoba, are the only provinces to have enacted laws governing the private sector that are recognized as being substantially similar to PIPEDA. None of these four provincial statutes provide a right to erasure comparable to the Regulation, but instead all contain various versions of a right for individuals to update and rectify erroneous information kept in a file concerning them. Furthermore, each such provincial statute includes a “limited retention” principle applied to the right to collection, use and disclosure of information, such that, to highlight one province as an example, according to Quebec’s an Act Respecting the Protection of Personal Information in the Private Sector (“PIPP”), information may only be retained for as long as necessary to fulfill the purpose for which it was collected. Moreover, PIPP provides that where consent is required, it must be free, clear, informed and specific and, in connection therewith, individuals concerned may require personal information collected be deleted, but only where such information was collected otherwise than according to law. In Quebec, in addition to the rights granted under PIPP, the Civil Code of Québec (the “CCQ”) protects the right to privacy at large. It prohibits anyone from establishing a file on another person without having a serious and legitimate reason for doing so. It further prohibits anyone keeping such a file from communicating the information contained therein to third parties or using it for purposes not relevant to the purpose of the file, unless the person concerned consents to such use or disclosure. The CCQ gives anyone whose personal information is contained in such a file the right to demand deletion of information but only where the information collected is obsolete or unjustified by the purpose of the file. Similarly to the provincial statutes, PIPEDA prohibits any unauthorized use or disclosure of personal information collected by organizations for purposes other than those for which it was collected and grants concerned individuals the right to require such organizations to rectify any personal information, which includes, as appropriate, the correction, addition and deletion of information, that is inaccurate or incomplete, however, this right is conditional upon the individual successfully demonstrating such inaccuracy or incompleteness and furthermore organizations do not have to grant individuals access to their personal information if they provide satisfactory reasons not to do so. PIPEDA also calls for respect of the “limited retention” principle and provides that organizations should erase data that has become obsolete, unless the individual consents to its retention, but fails to explicitly provide the right for individuals to request erasure in the absence of the data becoming obsolete or which is inaccurate or incomplete and remains silent with respect to any right to withdraw consent. Contrary to what has been proposed by the Regulation, the existing rights to “erasure” under the laws applicable to the collection of data both at the provincial and federal levels in Canada are quite limited. Other significant differences between the Canadian and proposed European regimes include when and how consent to the collection of information is required, the extent to which third party disclosure is regulated and the severity of sanctions imposed upon any breach. Possible Effects on Canadian Businesses Once in force, the Regulation will apply not only to companies processing data within Europe, whether European based or multinational with branches in Europe, but will also extend to European companies whose data processing is conducted outside of the EU, such as non-EU based cloud data centers, as well as non-EU companies that conduct any data processing of personal information of individuals in the EU. Canadian companies operating outside of the EU but offering products or services to individuals within Europe, irrespective of whether such products or services are offered at no cost to the consumer, would thus be caught by the Regulation. What’s more, is that non-EU companies not directly subject to the Regulation by the nature of their own commercial activities may also be affected by the reform in cases where they conduct business with EU companies and are recipients of data processed in the EU. Given the large financial incentives to comply with the Regulation and the responsibility of companies subject thereto for personal information in their possession or custody, including information transferred to a third party, non-EU companies may find their EU-based partners insistent upon their implementing measures necessary to ensure compliance with the Regulation on a global scale, despite not legally being bound to do so, which in turn may prove quite costly. The introduction of similar legislation in Canada could potentially bring with it tremendous cost to existing businesses. To cite one example, companies would need to find a way to ensure that personal data is stored appropriately, such that it is effectively possible to delete such personal data upon request. The current draft of the Regulation includes a limitation to the right to erasure and provides that where “the particular type of storage technology does not allow for erasure and has been installed before the entry into force of this Regulation” data should be “restricted” instead of erased. How this grandfathered right is to be interpreted and applied practically will be of interest to many. Could this be reflective of a global trend to come in privacy law? Pointing in that direction is the recent legislation amendment adopted by the State of California which grants minors a right similar in nature to the right to erasure proposed by the Regulation and specifically, to remove posts they have made on Internet Web sites and mobile apps, such as social-media giants Twitter and Facebook. It further requires service providers to make clear “how the minor may remove or, if the operator prefers, request and obtain the removal of content or information posted on the operator’s Internet Web site, online service, online application, or mobile application”. While the legislative amendment requires the removal of such posts from display, it does not require that the data be removed from the service providers' servers and further does not require the service providers to erase, or have erased, any content copied or posted by a third party or any posts in which others “mention” a minor. Similarly, the Regulation expressly provides that the right to erasure shall apply “especially in relation to personal data which is made available by the data subject while he or she was a child”. As a country that has a strong history in protecting the fundamental rights and freedoms of its citizens, is Canada next in line? At this preliminary stage, it remains unclear precisely how and to what extent the Regulation may impact Canadian businesses and exactly which type of business are specially targeted. The evolvement and status of the Regulation should be carefully watched to keep abreast of and monitor the ways in which the reform may affect operations of companies doing business in Europe and whether such reform may be first moving towards a bigger global trend. LIBE has called for the final text of the Regulation to be agreed upon with the Council of the EU before May 2014, although it is expected that 2015 may be more realistic. The current draft of the Regulation extends a two year grace period prior to coming into force, such that businesses subject to the Regulation would need to take measures for compliance as early as 2016 or 2017. personal data personal information privacy En savoir plus sur Sophie Gupta Voir Rechercher des publications Lire TechLex de McCarthy Tétrault : source incontournable pour les nouvelles en droit de la tec... TechLex de McCarthy Tétrault : source incontournable pour le... TechLex de McCarthy Tétrault : source incontournable pour les nouvelles en droit de la technologie au Canada par Christine Ing ... Christine Ing Droit de la concurrence/antitrust et de l’investissement étranger Lire The End of a 7-Year Saga: Supreme Court of Canada refuses leave to appeal in abuse case ag... The End of a 7-Year Saga: Supreme Court of Canada refuses le... The End of a 7-Year Saga: Supreme Court of Canada refuses leave to appeal in abuse case against Toronto Real Estate Board 24 août 2018 Anglais seulement Lire Record Your Breaches: Prepare for Breach Record Inspections from Federal Privacy Commissio... Record Your Breaches: Prepare for Breach Record Inspections... Record Your Breaches: Prepare for Breach Record Inspections from Federal Privacy Commissioner 19 juin 2019 Anglais seulement Recevez nos derniers billets en français Inscrivez-vous pour recevoir les analyses de ce blogue. Pour s’abonner au contenu en français, procédez à votre inscription à partir de cette page. Adresse courriel Veuillez entrer une adresse valide Consultez nos liens rapides : MT❯Divisions MT❯3 MT❯Réseau MT❯Jeu MT❯iplus Pourriel © 2003 - 2019 McCarthy Tétrault S.E.N.C.R.L., s.r.l. [[/image_url]] [[#offices]] [[titles]] [[#titles]] \| [[/titles]] [[offices]] [[/offices]] [[#telephone]] t. 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__label__wiki	0.805478	0.805478	The advice every parent of a teenager needs to hear, urgently. Behold. The female psychological thriller you need to read. The book that taught me there are alpha-bitch mums at every school. Ask Bossy: I can't STAND my best-friend's five-year old son. The parental Instagram trend that's a bit odd. I paid a complete stranger to listen to me talk. What everybody got so wrong about The Bachelor 'villain', Keira. Meshel Laurie talks to conspiracy theorist David Icke. Some of his beliefs are... out there. VNSFW: Five things you need to know about anal sex before you try it. The story behind Coldplay's name could be kinkier than you realised. This woman needs an army of followers. The Aussie novel Nicole Kidman is completely obsessed with. Easy ways to exercise that don't include active-wear. You might've had a 'natural' birth. That doesn't make you morally superior. When men fall in love with sex workers. Yes, it happens all the time. Bec Sparrow: "I'm so sick of being told there's something wrong with how I look." Introducing parenting consultants, the answer to all your struggles. Meet the Australian author whose advice led Oprah to make the biggest decision of her life. Ask Bossy: My boyfriend dresses so badly. How do I tell him without hurting his feelings? Here's your chance to be part of The Mamamia Book Club. Don't miss out. "The genius de-cluttering trick that fixed my life." Nikki Gemmell's genius method for limiting her kids' screen time. The most powerful couple in Australian media don't want you to know they are a couple. The Netflix documentaries you need to be watching. Why isn't there a #blacklivesmatter movement in Australia? Parenting Hack: Get yourself a mantra before you go insane. "The best place to have sex is in a graveyard", says Alain de Botton. Confession: The reason I'm watching Barracuda has nothing to do with the storyline. There is now a name for people who rudely check their phone while they talk to you. How you can become a reality TV star, from the woman that casts our favourite shows. 11 People to unfollow on social media right now. Behind-the-scenes with one of Australia’s most powerful journalists. One of The Bachelor couples is getting a spin off show. The nitty gritty details of life in the Foster Blake household. Help. How do I break up a ten-year-relationship with my hairdresser? The secrets of the longest-running children's show in Australia. The big fat problem with saying Leigh Sales looks great on TV. (Even though she totally does.) Robin Bailey has a message for the friend who betrayed her. Zoe Foster Blake tells us her biggest rule for when fans meet Sonny. How to decode what teenagers are really saying. Meet Mr Maker - a rock star to people under three-feet tall. Serial's Adnan Syed has been granted a new trial.	cc/2020-05/en_middle_0111.json.gz/line2771
__label__wiki	0.629598	0.629598	Is Beyoncé Working on New Music? A Netflix special is reportedly also in the pipeline. In the two years since the release of Beyoncé's sixth album Lemonade, the Beyhive has been abuzz with speculations about the singer's next trip into the studio. We were temporarily satiated by last year's Everything is Love (a surprise collaboration with her husband Jay-Z), but fans are itching to know when we can expect a new solo album. Fortunately, Beyoncé is reportedly hard at work on some new music—B7 could be closer than we think! Before you start with the conspiracies about what the vibe of the next album (the Hive loves a conspiracy theory), slow your roll. The music might not be what you're thinking. Per Us Weekly, our fave is actually in the studio recording "a couple new tracks [for] a deluxe album filled with old songs." Which means that any one of the albums in Bey's amazing discography could be getting an update...or maybe we're finally getting a full Beyoncé compilation album! Imagine "Baby Boy" (Dangerously in Love) smoothly transitioning to "Hold Up" (Lemonade). I'm living! Along with the deluxe album, the Grammy winner is also said to have signed off on a Netflix documentary that follows her history-making Coachella set in 2018. This is huge for those of us who have begging and pleading for something similar to The Beyoncé Experience Live, the special DVD release that recapped her third world tour of the same name. Just the thought of being able to relive Beyoncé's epic Coachella performance (including that cute moment with Solange) has me ready to to stop playing around and finally get my own Netflix account instead of leeching off of someone else. Growth. Between new music, a documentary, and the July release of The Lion King, summer 2019 definitely belongs to Beyoncé, and we legit cannot wait. The 14 Best Eye Creams for Dark Circles Mother's Day Gifts Under $75 That Don't Look Cheap 5 Ways to Wear Your New Denim Skirt Ineye Komonibo Ineye (in-NAY-yay) Komonibo is the editorial fellow at MarieClaire.com. The Ultimate Valentine's Day Playlist Chelsea Clinton Announces 3rd 'She Persisted' Book Who Is 'Bachelor' Contestant Kelley Flanagan? Who Is 'Bachelor' Contestant Alayah Benavidez? The Best Korean Dramas to Get You Hooked The Best New Music of 2020 (So Far) Listen Up: Gripping New True Crime Podcasts 'The Bachelor' Has Already Finished His Season Unmissable Horror Movies Coming Out This Year Who Is 'Bachelor' Peter's Mom Talking About? All 5 Parts of the Beyoncé Documentary are Here, Hooray! (VIDEOS) Sound On: The 7 Best Albums We Heard in March Sound On: The 5 Best Albums We Heard in April Surprise! Beyoncé's New Album Has Arrived Beyoncé Might Drop an Album Featuring Adele Tomorrow Beyoncé Owns 2014 with Her New Calendar	cc/2020-05/en_middle_0111.json.gz/line2773
__label__cc	0.727971	0.272029	مرجع \| MARJ3 Everyone Deserves To Be Aware Scholarships & Opportunities MARJ3 Articles Fellowships in Humanities and Social Science From The American Philosophical Society in USA 2020 1 October 2019 (for January 2020). 2 December 2019 (for March 2020). (Partially Funded) The American Philosophical Society – Franklin Research Grants 2020 The Franklin program is particularly designed to help meet the costs of travel to libraries and archives for research purposes; the purchase of microfilm, photocopies, or equivalent research materials; the costs associated with fieldwork; or laboratory research expenses. Foreign nationals not affiliated with a U.S. institution must use their Franklin awards for research in the United States. Special Programs within the Franklin Research Grants: APS/British Academy Fellowship for Research. APS/Institute for Advanced Studies in the Humanities Fellowship for Research. Opportunity Focus Areas: Required Languages ALL WORLD COUNTRIES. Program Period For a minimum of one and a maximum of two months. (APS/British Academy Fellowship for Research in London). Between two and four months. (APS/Institute for Advanced Studies in the Humanities Fellowship for Research in Edinburgh). Eligibility Requirements (Criteria) Applicants are expected to have a doctorate or to have published work of doctoral character and quality. Ph.D. candidates are not eligible to apply, but the Society is particularly interested in supporting the work of young scholars who have recently received the doctorate. Independent scholars and faculty members at all four-year and two-year research and non-research institutions are welcome to apply provided that all eligibility guidelines are met. American citizens and residents of the United States may use their Franklin awards at home or abroad. Applicants who have previously received a Franklin grant may reapply after an interval of two years. Foreign nationals not affiliated with a U.S. institution are eligible to apply for projects to be carried out in the United States. Funding is offered up to a maximum of $6,000. Grants are not retroactive. They are not intended to meet the expenses of attending conferences or the costs of publication. The Society does not pay overhead or indirect costs to any institution, and grant funds are not to be used to pay income tax on the award. Grants will not be made to replace salary during a leave of absence or earnings from summer teaching; pay living expenses while working at home; cover the costs of consultants or research assistants; or purchase permanent equipment such as computers, cameras, tape recorders, or laboratory apparatus. First Step: Register a new online account from here Second Step: You will need to answer some questions related to the program from here to be eligible to apply for funding. Third Step: You will verify that all materials: including the required two letters of support, and then submit it. Know more about this opportunity: Marj3 recommended links To learn how to write CV, Essays, Personal statement, and know about recommendation letters click here: This Scholarship Published by: ” Mustafa Abulhamd / Egypt “ Reviewed by” Hanine Aymen/ Egypt “ ” Nada Ahmed / Egypt “ MARJ3 Intern MARJ3 Scholarships team Author: Mustafa Abulhamd Recent Scholarships Beiersdorf International Internship 2020 (Fully Funded) Win Prizes worth 600$ in Visualize Beginnings photo contest 2020 University of Tokyo Summer Internship in Japan 2020 (Fully Funded) Win Prizes worth 500$ in My Favorite Sweater photo contest 2020 Investigative Journalism Competition in USA Scholarship for Undergraduate & Graduate from the Government of Brunei Darussalam 2020 “Fully Funded” Apply Now to SAWIRIS Scholarship Program (Fully Funded) Participate In The MENA Innovation Challenge and Win Fully Funded Trip to Berlin Win 50.000 Turkish Liras with TRT Documentary Awards The Global Forum for Higher Education and Scientific Research in Cairo 2020 © Copyright 2018 MARJ3.Com. All Rights Reserved. by MARJ3	cc/2020-05/en_middle_0111.json.gz/line2774
__label__cc	0.614743	0.385257	Subscribe to Marketing Daily Lay Of The Land: Creating Ecosystem Maps by Laura Patterson , June 7, 2011 For many organizations growth comes from entering a new market. Today most organizations recognize that venturing unprepared into unchartered territory is fraught with risk. When it comes to entering new markets, it helps to have a map. This map is known as an ecosystem map. Ecosystem maps serve as a valuable tool for getting the lay of the land in a new market, assessing the opportunity, and identifying the best points of entry. Having the answers to which buyers and organizations are the best points of entry, which organizations can and will create barriers and road blocks, where are the landmines, who are potential guides and partners can make all the difference in your rate and degree of success. What exactly is an ecosystem? The dictionary defines an ecosystem as "an ecological community together with its environment, functioning as a unit." If we apply this definition to the business environment, we can describe a business ecosystem as the network of independent entities that comprise members of a market community. An Ecosystem Map As we are prone to say, "A picture paints a thousand words." An ecosystem map provides a visual representation of the network. It depicts all the network members, such as buyers, competitors, distribution channels, and influencers, and graphically represents the relationship of these members to each other. A key value of the map lies in its ability to identify and visually represent these relationships. Five Steps to Creating and Using an Ecosystem Map We recommend five primary steps to create an ecosystem map. As you complete the third step, opportunities and roadblocks will become visually evident. By the time you complete the fifth step you will begin to have the insight you need to decide whether to become a player in the ecosystem and how. 1. Define the scope: Because ecosystems can actually overlap, the first step in creating an ecosystem map is to define the frame of reference for the ecosystem map. An ecosystem can be created around a company, such as the Microsoft ecosystem, or around a platform such as the iPod ecosystem, or around an industry or a vertical such as the health care computing ecosystem. 2. Identify the members: Every member of an ecosystem plays a role. There will be enablers-members who provide key technologies or capabilities that enable the members to effectively solve problems and compete. And there will be those members who attempt to control technologies, standards, partnerships and channels. At a minimum you will want to identify the members in the following groups when you create your ecosystem map: buyers, competitors, influencers and channels/partners. Buyers are those members who can potentially benefit from your offer. In a vertical market you may need to segment your buyers into groups. You will want to organize these members by those who are most likely to buy. Competitors are those organizations who you will need to compete against whether directly or indirectly for the buyers' resources. Remember to include the big players as well as any niche players. Influencers are those members who buyers rely on for decision making guidance. In a business ecosystem these might include editors and reporters in publications, market and financial analysts, trade associations and lobbyists, industry experts, etc. Channels/partners are those members who help insure access and availability of the offer to the buyers. The key to map is to not only identify all the major players, but to also identify the value of each player. For example, the potential dollars per buyers, the market share currently held by a competitors, etc. Your goal is to understand who the key members are in each group. 3. Identify the relationships among and between members: Once you have identified the key players the next step is to identify the relationships between the players. The purpose of this step is to identify the barriers and opportunities. For example, is the chairman of the board of a key association also a member of the leadership team at a primary competitor? If so, what barrier might that present? What if the chairman of the board of a key association is a member of the leadership team at a primary channel partner? What opportunity might that present? How many of the main buyers are the primary competitors already doing business with? Do some buyers or sub-segments offer better points of entry because there are fewer connections between these buyers and competitors? Are there some influencers and organizations that align with a particular cluster of customers or competitors? How are the competitors aligned with the channels? 4. Paint by numbers: As part of the finishing the map you need to add the details that will help you assess the viability of the entering the ecosystem, what and where you can have impact. Answers to the following types of questions can help you round out important details: For the entire ecosystem: the total revenue, the number of ecosystem members, the general trends in the ecosystem. For buyers: the number and size of each segments, who the top five players are in each segment, the size of opportunity in each segment and what barriers exist per segment. For competitors: the number of competitors and the degree of concentration of competitors in each segment, who are the top direct competitors in each segment, their competitive advantages, primary customers, and key products. For influencers: the number of individuals/organizations that specialize in analyzing the ecosystem and its members, their areas of focus, the number of recognized technical experts that have influence on the decisions of the buyers in the ecosystem, the primary publications that keep tabs on the ecosystem, the reporters and members of the press who track the segment trends and players, technologies, and issues, the members who organize events and conferences in this ecosystem, the most important events, and the number and type of industry organizations and firms (such as lawyers, think tanks, lobbyists) that exert influence. Remember to think about the influencers both from an online and offline perspective. 5. Assess the viability of the ecosystem: Armed with your map you can assess the attractiveness and health of the ecosystem for your organization and the merits and issues of entering the ecosystem. Use the map to determine whether the ecosystem is stable and/or has room for new players who can deliver new functionalities, improvements to quality, speed or lower costs. A healthy ecosystem continuously creates and grows niches; assess whether this ecosystem appears to have this ability. Based on what you learn, describe the desirability of participating in the ecosystem, where you see the best points of entry in terms of segments, buyers, channels, and influencers, and the degree of difficulty in establishing a position for your company. If your assessment reveals that the ecosystem is attractive and healthy, that there are viable points to successfully enter and gain traction in the ecosystem, then your next step is to develop a go-to-market plan. Use your map to guide your entry, to define areas that could delay your entry or increase your costs to enter, and to reveal potential connections with possible friendlies among the influencers, channels and potential initial buyers. LAURA PATTERSON, President, VisionEdge Marketing More from Marketing Daily Chick-fil-A Offers Loyalty Nuggets, 'Seated' App Gives Partner Discounts Volvo Plays Up Safety For Super Bowl Contest First Chevy Corvette Stingray Goes For $3 Million Volkswagen Expands Arts Support In NYC Great Clips Adds NCAA To Sports Deals	cc/2020-05/en_middle_0111.json.gz/line2781
__label__wiki	0.651197	0.651197	« Memphis Pets of the Week (12/31/19-… \| Ballet Memphis’ Dorothy Gunther Pug… » Rate of Juvenile Transfer to Adult Court ‘Appalling’ Posted By Toby Sells on Tue, Jan 7, 2020 at 12:02 PM Countywide Juvenile Justice Consortium In the year following the end of federal oversight, black kids are still treated more harshly in one key area of Shelby County Juvenile Court. That’s the conclusion of some criminal justice reformers. But law enforcement officials say violent crime is real and rampant in Shelby County and punishment needs to be tough to meet it. The key area reformers point to comes in transfers to adult court. Sometimes, when a minor commits a violent crime, they are moved from juvenile court to adult court, tried as adults. In regular criminal court, the sentences are tougher, the stakes of crime are much higher. Shelby County Juvenile Court/Facebook In Shelby County, the cases of 90 children were transferred from juvenile court to adult court in 2019. The figure is way above other jurisdictions in Tennessee. Transfers here were higher than in 2018, when federal monitors still watched the court. At least 87 of the 90 children transferred to adult court last year were children of color, and 86 of those were black, according to Josh Spickler, executive director of Just City. “It’s appalling,” Spickler said. “The county is 53 percent African American, and this is our county juvenile court. So, there’s a clear disparity. There always has been. So this is no surprise.” “It’s appalling.” click to tweet This disparity is what brought federal monitors from the Department of Justice (DOJ) in 2012. They watched the Memphis and Shelby County Juvenile Court until October 2018, leaving after many local leaders urged them to conclude their work. In February, Juvenile Court Judge Dan Michael declared “mission accomplished” during his state of the court address, touting the end of federal oversight. However, many — including Shelby County Commissioners Van Turner and Tami Sawyer — said more work was to be done. “So this whole notion that it was a successful closure, I think is somewhat fabricated,” Turner said. In 2017, 92 cases of children were transferred from juvenile court to adult court. (That same year, four such cases were transferred in Nashville.) In 2018, the transfer number fell to 78 (76 of them were black, according to Just City). Last year (the first full year since federal oversight ended here), the number rose to 90. Transfers to adult court must be first requested by prosecutors in Shelby County District Attorney Amy Weirich’s office. After that, the decision is up to a judge or magistrate. To warrant a transfer to adult criminal court, the offense has to be serious, and Weirich says they are, and crime here is unlike it is in the rest of the state. “We are not Davidson County or Hamilton County,” Weirich said. “We are Shelby County. And in Shelby County in each of the last three years, over 600 serious violent crimes — murder, rape, robbery, kidnapping — have been committed by Shelby County juveniles on Shelby County victims. Toby Sells Memphis and Shelby County Juvenile Court Judge Dan Michael declared “mission accomplished” during his annual state of the court address last year. “Of those 1,800-plus cases, transfer was the only option we had in 255 of them because of the offender’s record and the violent facts of the case.” Weirich said that nearly half of the transfers — 125 of 255 — were voluntary, by the defendant through an attorney. The rest were ordered by a judge or magistrate after hearing the evidence of the case and reviewing the child’s record. In August, the juvenile court here reported that overall charges against youth in Shelby County were down 9 percent in the first six months of 2019 (a total of 3,096 charges). It was good news, according to law enforcement officials. However, the rate of violent crimes (murder, rape, robbery, and other offenses) committed by juveniles in that time period surged. In the first six months of 2019, 463 charges of violent crimes by juveniles were filed. That was up from 282 such charges in the same time in 2018. But once juvenile offenders got to court, federal monitors found a host of problems. The court allowed “blatantly unfair hearing practices” that limited the ability of defense attorneys to represent their clients, according to a DOJ report. Other practices impeded due process, like denying psychological evaluations prior to a juvenile’s transfer to adult court. The report also said the court fostered a culture of intimidation against defense attorneys. Memphis Shelby Crime Commission Couple those facts with the outcomes of another DOJ report on discriminatory outcomes in juvenile court, “and you have a recipe for injustice,” according to Bill Powell, who served as the county's juvenile court monitor until 2017. “If you look at the reports, I don’t think [the numbers of transfers to adult court] are surprising,” Powell said. He said comparing the transfer rates of Shelby County and Davidson County were important. (Again, in 2017, Shelby County had 92, and Davidson county had four.) “We have the same laws; the difference lies in the administration of those laws,” Spickler said. Spickler said different cultures govern the Shelby and Davidson County Juvenile courts and ours says something about who we are. “This is an issue that impacts the whole county, and these are our children,” Spickler said. “This says a thing about every single citizen in Shelby County. This is what we’ve accepted. “This is how we want to deal with children who need correction, who need support and rehabilitation, and we’re going to deal with them much differently when they’re black.” As of press time, no one from juvenile court had responded to a request for comment. Tags: Memphis and Shelby County Juvenile Court, Just City, Bill Powell, Amy Weirich, Image Upward Juvenile Violent Crime Trend 'Disturbing' Juvenile Judge Declares "Mission Accomplished" County Attorney Seeks Full Release of Juvenile Justice Reports Year-End Crime Stats Show Successes, Challenges Keep the Flyer Free! Always independent, always free (never a paywall), the Memphis Flyer is your source for the best in local news and information. Now we want to expand and enhance our work. That's why we're asking you to join us as a Frequent Flyer member. You'll get membership perks (find out more about those here) and help us continue to deliver the independent journalism you've come to expect. Video: Bus Rider Discusses Transit Funding, Challenges, and More (News Blog) by Maya Smith Jan. 16, 2020, 3:16 PM U of M to Raise Minimum Wage to $13 an Hour, Campus Workers Say It's Not Enough (News Blog) Rate of Juvenile Transfer to Adult Court ‘Appalling’ (News Blog) Jan. 7, 2020, 12:02 PM 5 State Lawmakers Want to Halt Refugee Resettlement in Tennessee (News Blog) Memphis Pets of the Week (1/14/20-1/20/20) (News Blog) by Julia Baker Commercial Appeal Suspends Comments, For Now (News Blog) Jan. 2, 2020, 2:06 PM 8 Memphis Pets of the Week (1/14/20-1/20/20) Memphis Pets of the Week (1/7/20-1/13/20) Memphis Pets of the Week (12/31/19-1/6/20) Memphis Pets of the Week (12/17/19-12/23/19) Flyer How To: Let's Ride the Bird Food Fight: The Battle to Eliminate Memphis' Food Deserts MATA to Purchase First Set of Fully Electric-Powered Buses Commercial Appeal Suspends Comments, For Now crackoamerican FUNKbrs Strait Shooter BruceVanWyngarden Cory901	cc/2020-05/en_middle_0111.json.gz/line2786
__label__wiki	0.85413	0.85413	Monitoring and Reporting menu keyboard_arrow_down Fifth Plan and Progress Reports Spotlight Reports The Fifth National Mental Health and Suicide Prevention Plan Monitoring Mental Health and Suicide Prevention Reform: National Report 2019 Mental Health Reform Mental Health Reform menu keyboard_arrow_down Australian Mental Health Leaders Fellowship Connections: Vision 2030 Consumer and Carer Engagement Economics of Mental Health Mental Health Peer Work Development and Promotion National Children’s Mental Health and Wellbeing Strategy National Mental Health Research Strategy National Workplace Initiative Reducing Restrictive Practices Social Determinants menu keyboard_arrow_down Contributing Lives, Thriving Communities Equally Well Housing, Homelessness and Mental Health About menu keyboard_arrow_down COAG decisions on Mental Health Reform The National Mental Health Commission is encouraged by the outcomes of the Council of Australian Governments (COAG) meeting, held on Friday 7 December. COAG is made up of the Prime Minister, State Premiers, Territory Chief Ministers and the President of the Australian Local Government Association. COAG’s role is to initiate and monitor the implementation of nationally significant policy reforms that require cooperative action by all Australian governments. The COAG communique points to a new approach and a new process to develop a set of national targets and indicators for mental health reform focussed on a whole of life – a contributing life – view. This may hold more hope for the establishment of genuine and meaningful targets and reporting than other processes have yielded to date. Last Friday, COAG agreed to a number of actions which include: COAG welcoming the release of A Contributing Life: 2012 National Report Card on Mental Health and Suicide Prevention and reaffirming its commitment to mental health reform as an ongoing national priority COAG agreeing to jointly respond to the our first Report Card The Report Card reflected the community’s and sector’s call for the Prime Minister, Premiers and Chief Ministers to continue to directly support mental health reform. Without strong leadership from the top and strong links between housing, employment, education, health, family and child support, justice and corrections we will never give people the best chance of recovering and living contributing lives. As such we welcome that all governments have agreed to work together on a joint response to the Report Card’s findings and recommendations. Significantly, COAG agreeing to include national indicators and targets for mental health reform in its formal response to the Report Card, something the sector has been calling for, for a long time This advocacy culminated in an open letter to COAG signed by over 30 leaders and organisations last week urging COAG to commit to mental health reform and to set specific targets to measure progress. This was an incredibly important letter that showed unity and a shared vision across the many different sectors that support people with mental health issues and their families. Our Report Card also reflected these views and challenged governments to be brave enough to set goals and targets for improving mental health and reducing suicide, and be judged by the community on their results. These indicators and targets must be based on helping people and families to achieve contributing lives. As Commission Chair Allan Fels said in The Australian newspaper last week, “Without a set of national indicators and clear targets, that properly show Australia’s “mental wealth” – whether we are promoting wellbeing and preventing illness, whether people’s lives are improving – and give all Australians a proper picture of progress, we will continue to limp along. If we can do this for homelessness and HIV, why not mental illness and suicide?” COAG releasing a Ten Year Roadmap for National Mental Health Reform 2012-2022 which sets out next steps and a process to: improve access to data, develop indicators and targets and develop a successor to the Fourth National Mental Health Plan COAG will set up a new working group on Mental Health Reform co-chaired by the Commonwealth Minister for Mental Health, Mark Butler, and a Minister appointed by the states and territories. The Roadmap also gives the Commission a role in bringing together people with lived experience of mental health issues, their families and support people, and other experts from around the country to work alongside and assist the working group. An Expert Reference Group, which the Commission has been asked to chair, will be formed. Right now we don’t have any further details about the group, but will make these available as soon as possible in 2013. The Commission acknowledges the traditional owners of country throughout Australia and their continuing connection to land, sea and community. We pay our respects to them and their cultures and to their elders both past and present. helpNeed help? arrow_upwardBack to top © Copyright 2020 National Mental Health Commission. All rights reserved.	cc/2020-05/en_middle_0111.json.gz/line2787
__label__cc	0.599734	0.400266	Home Album Reviews Carach Angren – This Is No Fairytale Carach Angren – This Is No Fairytale If you’ve spent the bare minimum amount of time on the internet, you’ve definitely come across one of those ‘ruined childhood’ posts that paint some inane, absurd theory over a beloved childhood show with the intent of corrupting its innocence with the foul goggles of adult life. Some people take an absurd, sordid enjoyment in this; the idea of unveiling the darker side to a familiar tale which many assume to be harmless and inoffensive. And it’s not like these ideas are even that uncommon in many traditional children’s fairy tales. The original version of Cinderella contains a gruesome scene where the stepsisters’ eyes get plucked out by birds, Struwwelpeter features a boy that gets his fingers cut off with scissors for sucking his thumb too much, and I’m pretty sure Hansel & Gretel breaks a metric shitton of child labor laws. Enter Carach Angren, a Dutch symphonic black metal trio (though the band prefers the schlocky term ‘horror black metal’) that takes pleasure in these tales. The ones where the characters may not live happily ever after. Each of their records acts as a concept album about various aspects of folklore, fairy tales and ghost stories, with their fourth full-length, appropriately titled This Is No Fairytale, weaving the band’s own transgressive, twisted, goth-a-rama folk tale. The record manages to avoid many of the pastiche symphonic black metal tropes, with the well-placed string sections often being fairly elaborate and complement the rest of the metal instrumentals elegantly without outshining them. Let me be clear though, elegance is hardly what the record aims for, manifesting itself on the traditional, more straightforward side of symphonic black metal, laden with raspy, snarled vocals rather than operatic cleans. A predominantly lyric-driven album, This Is No Fairytale is the band’s own love letter to bleak children’s tales, sprinkled with references to The Wizard of Oz and gingerbread houses intertwined with stomach-churning mentions of domestic abuse, anxiety and self-harm. Though there’s a degree of a tongue-in-cheek attitude in just how overtly sinister the lyrics are, most of them are laughably juvenile in their attempts to corrupt fairy tales. “The skies turned red instantly / While the candy cottage transformed into a huge festering ulcer / The stench of old blood and black pus / Mmm…”. Needless to say, I don’t think you can try to make gingerbread cottages sound terrifying without getting a few snickers from your audience. The instrumentals manage to hold a decent amount of weight on their own without the lyrics to support them, sporting a constantly shifting dynamic of rhythm, more in tune with technical death metal than symphonic black metal; still, the songwriting suffers from a rigid, artificial vibe which doesn’t quite keep the flow of a story, awkwardly trudging along from one section to the next with very little forward motion. The whole album’s essence is summed up with its closing line, “The real nightmare begins in reality.” It’s just a shame that essence is such am eye-rollingly childish, juvenile fantasy. Some intricate string sections give the instrumentals some great depth. One of the most eye-rollingly childish, edgy albums you'll listen to this year. Previous articleThem County Bastardz – Sick Daze Next articleTerra – Untitled EP A surprisingly weak and uninsightful review for metal blast. Seems the author either phoned in this review without much, if any, serious listening attention paid to the album, or, as I suspect, was clearly out of his element on this one. Noire – The Tracks of the Hunted Cynic – The Portal Tapes Suffocation – …Of the Dark Light	cc/2020-05/en_middle_0111.json.gz/line2788
__label__wiki	0.583408	0.583408	Home / Special Feature / Reel Affirmations / What’s Up Scarlet? What’s Up Scarlet? Review by Dan Odenwald Thursday, 10/19/2006, 9:00 PM Feature presentation, $9 at Landmark’s E Street Cinema ENGAGING AND frequently funny, What’s Up Scarlet? is a quirky little movie that follows the unlikely and unexpected love affair of Scarlet (the deliciously acerbic Susan Priver) and Sabrina (the sensual and exotic Musetta Vander). Set in Los Angeles, the story opens, unsurprisingly enough, with a traffic accident. (Is that the only way people meet in L.A.?) Scatter-brained Sabrina, wracked with nerves over an upcoming audition, rear-ends Scarlett, a high-strung, loveless career woman who owns her own dating service. Through a twist of events, Scarlet invites Sabrina, who is living out of her car, to stay with her for a few days. Through Sabrina’s warm personality and joie de vivre, Scarlet’s frigid heart begins to warm. A largely character-driven piece, the film succeeds on the strength of its performances. Susan Priver is wonderful as the tightly-wound matchmaker. A mix of sarcasm and vulnerability create the perfect pitch that entices audiences to fall for her. Musetta Vander is equally likable as the free-spirited actress who triumphs in overcoming Scarlet’s hard edges. When they eventually end up in bed together, it seems wonderfully natural, almost fated — not forced and contrived as so many straight-to-gay movies can be. The film is also nicely rounded out with a punchy performance by Sally Kirkland, who plays Scarlet’s manipulative and overbearing mother. Never content to simply pay her daughter a compliment, she agrees that Scarlet would be pretty if only ”she would get her teeth fixed.” Jere Burns turns in a cutting and humorous performance as the slacker, pothead brother, Benjamin. When he learns Scarlet has accidentally set him up with Ashley, a former porn star, he makes a play for Sabrina to exact revenge. If the movie falters at all, it’s because of its strict adherence to the formulaic elements of the romantic comedy. Girl meets girl. They become friends. Then something more. Tragic misunderstanding causes break-up. But love overcomes, and they live happily ever after. If this were a lesser movie, What’s Up Scarlet? would have collapsed under the contrivances. But under the sharp direction of Anthony Caldarella and the refreshingly lively performances, it’s not weighted down. Like the romance it seeks to portray, What’s Up Scarlet? is an unexpected surprise. Though many films bill themselves as romantic comedies, What’s Up Scarlet? has the unique quality of actually being one. — DO What's Up Scarlet? ← Previous Story Tang Tang Next Story → Animated Youth: Girls Shorts	cc/2020-05/en_middle_0111.json.gz/line2792
__label__cc	0.672614	0.327386	Home / Special Feature / Reel Affirmations / Zombie Double Feature! Zombie Double Feature! By Will O'Bryan on October 18, 2008 @wobryan Review by Will O’Bryan Rating: (4 out of 5) [Critic’s Pick!] Saturday, 10/18/2008, 11:30 PM Feature presentation, $10 at Lincoln Theatre Start your evening of the undead with an amuse-bouche of gnome-scented Reddi-wip. While Brian the Gnome Slayer ( ) has nothing to do with zombies, it makes as much sense here as anywhere. Sit back and enjoy this recap installment of our Lawnsdale local’s oddly gay battles with evil. Next up, Bruce La Bruce can be a bit much for the mainstream. Maybe it’s a love-or-hate relationship between La Bruce and the world. It’s as though he has a genuine, heartfelt message he is trying painfully to express. Sometimes it works, with some people — often not, with others. With Otto; or Up With Dead People ( ), La Bruce may have made his most accessible movie to date, beyond even Hustler White. That might not sound like a good thing to La Bruce, but it is. His message is sharper, his craft more honed, his soul more exposed. He is beautifully strumming chords that resonate within everyone. Of course, with La Bruce that means you’re in for graphic scenes of gay-zombie sex, including the close-up, penis-penetrates-wound insertion shot. Lighten up, it’s just a movie. Don’t let La Bruce disgust you. That’s simply a filter he employs to keep out mediocre tastes. If you can stomach those initial, graphic scenes, you will be rewarded with a movie that is clever, funny and achingly touching. Otto (Jey Crisfar), our antihero zombie, is introduced by Medea Yarn (Katharina Klewinghaus), the director of Up With Dead People, the movie within the movie: ”Once upon a time, in the not too distant future, there unlived a zombie named Otto.” The movie is full of these bad zombie puns, but they help ease the mood. As does the sex. Ever wondered what a gay zombie orgy might look like? Oddly like six or seven guys having sex among mannequin limbs, using barbeque sauce as lubricant, some offal thrown into the scene for adequate gore. La Bruce likes his camp. But there is no denying the heart. Stone-faced Otto shuffles out of a beautifully vibrant field of yellow flowers and the effect is breathtaking. And writer-director La Bruce is able to make so much of metaphors with the zombie theme: consumption, heartlessness, life, death, desire. Otto suffers with a distant memory of his ”life” and general disdain for the living, though he doesn’t have the heart to eat them, which he rationalizes. ”It occurred to me I might have been a vegetarian. Or worse, a vegan.” Zombies as allegorical figures are more amusingly explained by Medea, herself possibly a parody of La Bruce and his ilk — as drawn by detractors. ”The new wave of gay zombies had emerged,” she heralds. ”Lonely, empty, dead people inside — the typical porn profile.” The icing on the cake is the soundtrack. Particularly catchy is the upbeat ”Everybody’s Dead” by the Homophones. With Quarantine in theaters and World War Z in bookstores, La Bruce is catching a timely wave. If audiences can find it in themselves to digest his non-conventional treatment of universal, human themes, Otto; or Up With Dead People may even be the hit of the festival. Part II of the festival’s ”Zombie Double Feature,” Zombie Prom ( ) blends The Toxic Avenger with equal parts Grease and Hairspray for a goofy musical set in Enrico Fermi High. RuPaul as Ms. Strict, the principal, still looks fierce as she instructs the home-ec class, ”A nuclear holocaust is no excuse for a runny meringue.” And RuPaul is the gayest thing about Zombie Prom, aside from the cute show tunes. Jonny (Darren Robertson), the rebel zombie, sings to Toffee (Candice Nicole), the popular girl, ”Say that you’ll be my wife. Say that you’ll share my afterlife.” With top-notch production values, it makes a satisfying dessert to the night’s lineup. Follow Will O'Bryan on Twitter @wobryan. ← Previous Story Watch Out Next Story → Antartica	cc/2020-05/en_middle_0111.json.gz/line2793
__label__cc	0.5799	0.4201	Miami New Drama's The Cubans Puts First-Generation Cuban-Americans Center Stage Zoetic Stage’s American Son Represents South Florida Theater at Its Finest Ta-Ta-Toos: Temporary Tattoos For Your Boobs, Courtesy of South Florida Ciara LaVelle Ciara LaVelle \| May 13, 2013 \| 12:17pm Hey ladies: Are you feeling unappreciated? Have you ever wished that strange men would oogle your cleavage more than they already do? Are you tired of reminding potential sexual partners that, even though your eyes are "up here," what you'd really like them to notice are your assets "down there"? GreenSmith Concepts Inc., based in Hollywood, Florida, can help. No, silly, not with self-esteem-boosting therapy sessions or women's studies classes. With temporary tattoos for your tits! Duh. They're called Ta-ta-toos, and according to their makers, they're designed to "highlight a woman's best assets... her cleverness and creativity." If only we'd heard about this before Mother's Day. The tattoos feature curved designs intended to be placed just above the neckline of your favorite low-cut blouse. Think Eve's tiger claw tattoos, except instead of fierce-looking tiger claws, you'll be wearing a female cliche straight out of a Cathy cartoon. There's the "Happy Birthday" collection, which conveniently lets you present your lady funbags as a gift to the birthday boy, with phrases like "Happy Birthday" and "Let's Celebrate." There's the "Risque" collection, ideal for the man who's not so great with innuendo, featuring more overt phrases like "Bite Me" and "Spank Me." (Wait -- is boob-spanking a thing now?) And there's a full selection of holiday tattoos. Give your slutty fill-in-the-blank Halloween costume an extra dose of promiscuity with "Trick/Treat"! Show him you love him where it counts this Valentine's Day with "I'm Yours/Be Mine"! Eschew the carols this Christmas and give him his very own set of "Jingle Bells"! The tattoos will last between five and seven days, are removable with rubbing alcohol, and cost about $10. And really, isn't that a small price to pay? After all, other men get to objectify your body all the time. Why not save them the trouble and just objectify yourself? Celebrate the joys of modern womanhood at tatatoos.com. Follow Ciara LaVelle on Twitter @ciaralavelle. Ciara LaVelle is New Times' former arts and culture editor. She earned her BS in journalism at Boston University and moved to Florida in 2004. She joined New Times' staff in 2011. Facebook: Ciara LaVelle Twitter: @ciaralavelle Trending Arts & Culture Director Yaron Zilberman's Film Incitement Chronicles... Nearly Seven Decades In, the Beaux Arts Festival's Mission Is... Why Is Wynwood's Museum of Graffiti Selling Its Artwork? The Seven Best Things to Do in Miami This Weekend	cc/2020-05/en_middle_0111.json.gz/line2796
__label__cc	0.606668	0.393332	Sunday, February 11, 2018 - 12:39pm Michigan topples Wisconsin, 83-72, despite late-game scare MADISON — On Sunday afternoon, Kohl Center had all the makings of a big matchup: a raucous crowd, highlight reels on the jumbotron and the suspense of an intense rivalry. And then the game began. Tuesday, February 6, 2018 - 10:10pm Ethan Wolfe: From ugly to uglier When the Wolverines falter, they don’t do it with turnovers or obvious sloppiness. It’s a sweeping malaise that permeates every other facet of their game. Poor free throw shooting nearly dooms Wolverines in win over Minnesota When his team isn’t hitting free throws, John Beilein has simple advice: picture your loved ones. “I usually tell them to think about their mother … relax them a bit.” Beilein admitted he didn’t relay the message to his team on Saturday against Minnesota, only one miscue of many that contributed to the Michigan men’s basketball teams foul shooting woes. Despite a 76-73 overtime victory over the Golden Gophers, the stench of a 12-for-28 performance from the charity stripe reeked and lingered. Amid four-game losing streak, Minnesota seeks rebound win over Wolverines Amid injury and controversy in a disappointing year, the Golden Gophers enter Crisler Center on Saturday on a four-game losing streak and with little to play for except pride. Behind Enemy Lines: Minnesota's Nate Mason and Jordan Murphy The Daily sat down with Jordan Murphy and Nate Mason at Big Ten Media Day in October to talk about battling depth issues, their lack of roster turnover and what their expectations for the season were. Michigan trudges to 58-47 victory over Northwestern If you spill a drink at a party, it’s a party foul. If the party’s theme was “spill your drink,” then, well, you did what you had to do and nothing more. For the beginning of Monday night’s contest against Northwestern, the Michigan men’s basketball team was exactly in this position. Facing the Wildcats’ zone defense, the Wolverines started 1-for-12 from three and coughed up the ball four times in the first 15 minutes, while also missing a number of defensive assignments. Report: Michigan coaching staff undergoing more shakeups Dan Enos is on his way out. Ed Warinner is on his way in. Simmons continues to earn trust, playing time Coming into the year, the departure of Derrick Walton Jr. was perhaps the most painful roster hit for the Wolverines. Jaaron Simmons was supposed to make it hurt a little bit less. Sunday, January 21, 2018 - 5:19pm Wolverines plagued by first-half offensive woes The platitudes and jests don’t do justice to how No. 23 Michigan has performed recently — its offense is non-existent, especially in the first half. Tuesday, January 16, 2018 - 12:49pm A memorable weekend for Michigan's seniors Senior guard Muhammad-Ali Abdur-Rahkman and senior guard Katelynn Flaherty each reached respective milestones over the weekend.	cc/2020-05/en_middle_0111.json.gz/line2799
__label__cc	0.742175	0.257825	University makes students attend anti-Trump speech While other campuses are clamping down on free speech and silencing controversial speakers, Campbell University in North Carolina is reportedly taking the opposite approach. They have scheduled a speech by a very controversial author/speaker who makes outrageous, sweeping accusations about large groups of people he doesn’t know based on their race – and he’s not only allowed to speak, but attendance at his speech will be mandatory for all fraternity and sorority members. The students are complaining that the Greek organizations are non-political, but the school doesn’t care: they will be forced to sit through the speaker’s offensive diatribe anyway. How can this possibly be condoned at an institution of higher learning? Oh, wait: it turns out this particular speaker is a rabidly anti-Trump leftist who claims that Trump is a white supremacist and Americans who voted for him are all racists and “suckers.” Okay, now it all makes sense. Note to parents considering a college for your kids: tuition to Campbell University is $28,820 a year, not including room, board and other fees. That seems like an awful lot of money. But I assume that mandatory admission to lectures by race-baiting demagogues is included free of charge. PLEASE LEAVE ME A COMMENT BELOW. I READ THEM! Permalink: https://www.mikehuckabee.com/2017/9/university-makes-students-attend-anti-trump-speech Charles M Campbell used to be a small denominational (Southern Baptist?) private 4-year college in rural NC "back in my day" of shopping colleges to attend. Sounds like the radical 60s leftover hippies took them over, too, just like in the big schools. Amelia Little Will be eagerly awaiting the headlines that tell us the university is making it mandatory for the same students to attend a speech by a conservative. Of course, will not be holding my breath on that. Besides this university would probably turn down any conservative speaker. Safety, ya know!!!	cc/2020-05/en_middle_0111.json.gz/line2801
__label__cc	0.579978	0.420022	Today's Newsletter February 16 Edition The message you have just received was delivered by Mike Huckabee and includes advertising powered by PowerInbox. These ads help bring this newsletter to you free of charge. Today's Commentary: Trump offers unique Food Stamp proposal --Sharyl Attkisson and the real story of "fake news" -- Rob Porter security clearance update -- Residents fleeing blue states -- Adam Schiff admits the truth -- Attorneys General come together -- Additional Mike Huckabee commentaries POLL: Do you support President Trump's proposal to provide food instead of money for the Food Stamp program? Vote now. If you enjoy the newsletter also, please forward it to a friend and tell them they can subscribe for free at MikeHuckabee.com/Subscribe Trump Derangement Syndrome has become such a pervasive malady that it may be time to add it to the DSN (Diagnostic and Statistical Manual of Mental Disorders). There is seemingly nothing that President Trump says or does that doesn’t send TDS sufferers into spasms of foul-mouthed fury, from cutting taxes to lowering unemployment to praising the troops. Latest case in point: what seems to be a fairly brilliant innovation for the food stamp program. The White House just unveiled a proposal based on popular “cook-at-home” services such as Blue Apron. People on supplemental food aid could enroll in the program and instead of getting all their benefits in the form of a debit-like card that lets them buy food, they would receive regular shipments of food direct to their doors. The boxes would include staples such as pasta, juice, canned goods, cereal and peanut butter. READ MORE OF MY COMMENTARY AND LEAVE ME A COMMENT. I READ THEM! Commentary continues below advertisement Sharyl Attkisson and the real story of "fake news" Unless you’re new to reading my commentary, you know that much of it has had to do with what we call the Death Of Journalism. Increasingly over recent decades, so-called “journalists” (quotation marks intentional) have shown themselves to be wedded more closely to their chosen narrative than to the real facts of a story. Why, who wants to bother chasing down facts when discovering them might create some obligation to mention them (and not on page B36), watering down or even negating the narrative? And who wouldn’t choose to run with a blockbuster story, no matter how feebly sourced, if it might create a hysteria that advanced one’s own deeply-held political agenda? A real journalist, that’s who. And one real journalist –- someone who doesn’t require quotation marks around that title –- is Sharyl Attkisson; in fact, I’ve mentioned that not long ago. In a recent TEDx Talk at the University of Nevada, she demonstrated why she needs to be cloned hundreds of times and sent to all the journalism schools around the country to teach J-101, along with a remedial course for all the professional reporters who apparently slept through it the first time. Rob Porter security clearance update Reporters refuse to believe that the data the FBI passed along about Rob Porter got stuck in the White House personnel security office, and they didn’t complete their investigation and inform the White House Staff for a year. Maybe it would be easier for them to understand if they knew just how mucked up the vetting process is. The previous Administration greatly expanded the number of positions that require background checks and security clearances, while also expanding the size of government. Result: Director of National Intelligence Dan Coats just told the Senate that the backlog of uncompleted background checks now stands at about 700,000. Getting a “top secret” clearance takes an average of 10 months and can easily stretch to a year or more. Jared Kushner, one of President Trump’s top advisers and his own son-in-law, has been waiting for a security clearance for 16 months and counting. So instead of demanding that Gen. Kelly resign because he isn’t the Amazing Kreskin and didn’t psychically sense a background problem with a staffer that was never reported to him, how about aiming the outrage at a more appropriate target: the inefficient, bogged-down federal security vetting process that is so hopelessly backlogged as to be virtually useless. Residents fleeing blue states If Liberalism is a disease, maybe it’s time for a quarantine. At the link, a look at how leftist policies make heavily Democratic states so unlivable that residents are fleeing for better lives in Republican states. Four of the top five states losing residents are deep blue, while four of the top five states gaining newcomers are deep red. The escapee trend is even more concentrated in heavily liberal cities, such as Detroit, Chicago and the new king of expatriation, San Francisco. Red states are even gaining new residents who are fleeing Canada, as our neighbor to the north lurches ever further to the loony left. Unfortunately, instead of simply thanking God and Greyhound that they’ve escaped the insanity, many former blue-staters are moving into successful red states, voting for the same liberal policies that ruined the places they just fled, and giving rise to the same crime, divisions, high taxes and depressed business climates that drove them out of the blue states. Before we have to build a wall around Texas, Florida or North Carolina, maybe these states need to create some sort of decontamination program for newcomers, so that they understand the unbreakable connection between voting for failed leftist policies and miserable failure. Adam Schiff admits the truth Remember last weekend, when Nancy Pelosi called it a “stunningly brazen attempt to cover up the truth” for President Trump to refuse to release the Democratic response to FBI FISA Court abuse allegations because it contained classified and sensitive information that might disclose secret intelligence sources and methods? Well, surprise: turns out it does. And you’ll never guess who actually admitted it: Democrat Congressman Adam Schiff. Nicholson challenges Baldwin Another example of why you have to read beyond the headline (and not get your news from late night comedians) if you really want to know the full truth. Republican Kevin Nicholson is challenging liberal incumbent Tammy Baldwin for her Wisconsin Senate seat. The story that’s provided lots of easy fodder for liberal jokes is that Nicholson’s own parents have donated the maximum allowed to Baldwin’s campaign. But there is much more to that story than you’ve likely been told. Turns out Nicholson never expected to have his parents’ support, since he’s from a long line of staunch Democrats. He’s the first in his family to depart from the liberal mindset. But he has a solid, interesting and very admirable reason for holding views opposite to those of his parents. If you’d like to know what caused his conversion and what Paul Harvey used to call “the rest of the story,” click the link. Additional Commentaries Transgender bathroom ruling Mass Exodus from California continues Let's get real about national security threats Media bias on display at the Olympics NYT story makes a great point about Russian-sourced dirt Trump is a dictator? President Trump's critics get it wrong Fun with Adam Schiff We know who conspired This should enrage every American Our Democrat friends have been unfairly judged Scandinavian medical morality Permalink: https://www.mikehuckabee.com/2018/2/today-s-newsletter-february-14-edition	cc/2020-05/en_middle_0111.json.gz/line2802
__label__wiki	0.850004	0.850004	Marines to Receive Precision-Guided Mortar Round in 2018 Marines with Golf Battery, 2nd Battalion, 10th Marine Regiment, 2nd Marine Division, fire 120 mm high explosive mortar rounds from an Expeditionary Fire Support System at Fort Bragg, N.C., March 9, 2015. (U.S. Marine Corps photo by Sgt. James R. Smith) Military.com \| By Hope Hodge Seck The Marine Corps inked $98 million contract this month for a GPS-guided mortar round that officials said will travel twice as far than traditional rounds and with triple the lethality. This precision extended range munition, or PERM, will be fielded to Marine units in early to mid-2018, said Joe McPherson, the product manager for Fire Support Systems at Marine Corps Systems Command. The 120mm-rounds are designed for the Marines' Expeditionary Fire Support System, a towed mortar that can fit inside an MV-22 Osprey along with the all-terrain vehicle that pulls it. The system can also be stored easily on an amphibious ship and delivered to shore via aircraft or landing craft. While the EFSS was fielded in the early 2000s, this GPS-guided round has been in development since 2011. The end of the wars in Iraq and Afghanistan reinforced the need to develop a precision mortar round for a system light enough to insert wherever Marines may need to operate in the future, McPherson said. The new round, he said, will also give the Corps the ability to use force in complex urban environments with surgical precision. "It allows us to ... minimize collateral damage and shoot in a more cluttered environment, in areas where you have to be more cognizant," he said. "Because it's GPS-guided, the very first round is going to hit exactly where you want it to hit." The round also expands the range of the EFSS from 8 kilometers to 16, or from roughly five miles to ten, McPherson said. In addition to GPS coordinates, they use tail fins to correct in the wind and glide toward the target. That range and accuracy does come with a price tag. Each of the 35-pound GPS-guided rounds costs about $18,000 McPherson said, compared to about $2,000 for the non-precision rounds. However, he said, the PERM rounds were estimated to cost $27,500 apiece before competition through the Defense Department's Better Buying Power policy drove the price down. The five-year contract, awarded to Raytheon Missile Systems out of Tucson, Arizona, will deliver about 4,300 rounds to the Marine Corps, including those to be fielded and an allowance for training and testing. The contract was awarded after a competitive demonstration phase, which wrapped up earlier this year. The Marine Corps will spend the next 15 months conducting a series of tests with factory-made rounds to ensure their safety and stability. Some Marine personnel will participate in those tests, McPherson said. -- Hope Hodge Seck can be reached at hope.seck@military.com. Follow her on Twitter at @HopeSeck. Marine Corps Topics Ammunition Mortars Gear and Equipment The Army Is Headed Back to the Drawing Board on Bradley Fighting Vehicle Replacement The Army for the fourth time is overhauling the plan to replace its venerable Bradley Fighting Vehicle. Two More Aircraft Carriers to Bring Boost of Almost $2 Billion to San Diego in 2020 San Diego is poised to become the home port of three Nimitz-class nuclear aircraft carriers in 2020. Tamara Campbell Won't Stop Advocating for Survivors of Domestic Violence HuffPost published a story about Campbell as part of a series of stories about domestic violence in the military. Trijicon’s New Handheld Range-Finder Will Map the Wind for Extreme Accuracy The Trijicon Ventus is the world's first handheld device with advanced wind mapping and wind detection. Military Opinion Most Popular Military News The Navy Once Called Him an ‘Unknown Negro Sailor.’ Now It’s Naming a Carrier After Him The Navy's acting secretary is breaking with tradition to name a powerful aircraft carrier in his honor. Space Force Offers First Peek at Camouflage Uniform The United States Space Force has only one member so far, but it appears the service utility uniform is already well under de... The B-52 Will No Longer Carry Certain Nuclear Weapons. Here's Why The B-52 Stratofortress will no longer carry the B61-7 and B83-1 nuclear gravity bombs as it prepares to carry the new long-r... 'Dopes and Babies' Fighting 'Loser War': Trump Reportedly Berated Military Top Brass Trump lashed out at the country's most senior military leaders just months into his presidency, according to a new book. Here's the New Light Machine Gun SOCOM Is Evaluating The new machine gun has come a long way from the prototype that Sig unveiled at SHOT Show last year. Latest Military Videos SHOT Show 2020: LWRC International Shows Off its Hot New Pistol-Caliber Carbine LWRC International's .45-caliber carbine has been in high demand and elusive since it went on sale in June. But... SHOT Show 2020: The Colt Python is back! It's back by popular demand! Made famous in "Starsky and Hutch" and "Magnum Force," Colt's Python revolver is legendary.... SHOT Show 2020: Could You Beat a Shooting Pro? Sig Sauer's shooting pros show off their blisteringly fast and accurate marksmanship at Sig's 2020 range day ahead of... SHOT Show 2020: New Sig Sauer Machine Gun This Army Field Artillery Officer is Also an Upscale Fashion Designer Julian Woodhouse is a field artillery officer in the U.S. Army Reserve. His mission is to destroy, defeat or... Two Immigrants, Pastor, Army Sergeant Guilty of Conspiracy to Commit Fraud Each defendant was convicted of making at least one false statement to U.S. immigration authorities. Remains of Fallen US Soldier Returned to Fort Bragg The family of Staff Sgt. Ian McLaughlin greeted his flag-draped casket at Pope Army Airfield. 'An Embarrassment to the Navy:' Modly Censures Chief Accused of Taking $10K in Gifts The "Fat Leonard" scandal has resulted in bribery charges against several high-ranking officers and senior enlisted sailors. US Sends Warship Through Taiwan Strait Days After Island Reelects Separatist Leader The Yokosuka-based guided-missile cruiser USS Shiloh sailed through the strait on Thursday. Air Force Captain who Fled Court-Martial Hearing Found Dead Capt. Kevin Larson did not appear for a court-martial hearing at Nellis Air Force Base. Police have not indicated if the cars in the other incidents had any connections to the Air Force base. US, Japan Defense Officials Discuss How to Address Chemical Contamination Near American Bases Tokyo officials detected the chemicals, commonly known as PFOS and PFOA, in two wells near Yokota Air Base. Marine's Moving Truck Gets Stolen with His Father's Ashes Inside Surveillance footage from the hotel parking lot shows the thieves getting into the truck and driving away. Coast Guard Officer Accused of Plotting Attack Asks for Leniency Hasson, 50, has pleaded guilty to gun and drug charges and is scheduled to be sentenced Jan. 31. Group Has Raised $56 Million for Coast Guard Museum Construction of the museum has been pushed back due to two other projects scheduled for New London. Coast Guard Wrapping Up Study on Why Minority Members Leave the Service The Coast Guard will wrap up a study examining why minority service members are leaving its ranks.	cc/2020-05/en_middle_0111.json.gz/line2804
__label__cc	0.635347	0.364653	Simon Ball I am a leading planning and environment specialist with extensive experience advising on, and guiding clients to obtain their licence to operate and then advising them on protecting it as their project develops. In doing this I advise on environment and planning approvals (both State and Federal), water licence, compulsory acquisitions, native title agreements and mining laws. I do front and back end work. Having worked as both an engineer and lawyer, and both for Government and in private practice, I provide legal advice with a strong practical and commercial focus. Advise South32, Shenhua, Yancoal and Rio Tinto in respect of environmental and planning matters for their NSW operations. This has included all advice on obtaining approval for the Bulli Seam Project, Watermark Coal Project and the Warkworth Continuation Project at both a State and Federal level Advised on all environment and planning approvals for Port Waratah Coal Services fourth Coal Terminal in Newcastle which was recently approved Advised on the environment and planning aspects of the Port Botany transaction, including legislative review, consideration of environmental and planning controls and amendments to legislation and planning instruments. I provided advice on managing risk relating to environment and maritime issues such as contamination and pollution. At the time this was the largest and most complex undertaking of its kind in Australia Advised Roads and Maritime Services in enforcement proceedings in the NSW Supreme Court against a local council that refused to make a substantial area of open space land available for the New M5 midway tunnelling compound contrary to trust arrangements applying to the land. Judgment was in favour of RMS. The court held that the local council had an obligation to make all or part of the land available, at no cost, to RMS when required for road or ancillary purposes in perpetuity without the need to initiate the compulsory acquisition process	cc/2020-05/en_middle_0111.json.gz/line2805
__label__wiki	0.703091	0.703091	carmella.inchierchiera @carmellainchierchiera Sally Grabbed That Shotgun carmella.inchierchiera » Audio » Sally Grabbed That Shotgun album: Songwriters Two streams: 66 Sally Grabbed That Shotgun Produced + Performed by Nelson Blanchard Written by Carmella Inchierchiera Read Full Song Info Produced + Performed by Nelson Blanchard Written by Carmella Inchierchiera 02/12/17 07:57:09PM @avmo: Another beautiful tune with exquisite solo guitar playing, great backing vocals...very nice. 09/27/16 12:40:30PM @gary-shukoski: I'm putting this on repeat and giving a few more good listens! Really cool track! This is AMAZING! Listening for the first time with headphones. This has so many great elements in here: great sounding guitars, vocals and harmonies, great sounding hook in the chorus, nice mix. Overall BEAUTIFULLY done!!! Blogs: 10 Contact Joined September 25, 2013 Carmella Inchierchiera Award Winning Songwriter (ASCAP) Songwriting Member, LYRICSINMYHEAD Publishing has been writing songs for over 40 years, just... Read Full Biography Carmella Inchierchiera Award Winning Songwriter (ASCAP) Songwriting Member, LYRICSINMYHEAD Publishing has been writing songs for over 40 years, just within the last Seven years she was finally able to get some of her songs out to the public. She is a songwriter/composer with a very original, unique style. She can write a heartfelt ballad and bring the listener to tears from the emotion in the song or can flip things upside down and bring down the house with a Honky Tonk up-beat country song with attitude. She has released 22 songs since March of 2008 here are just a few of those releases. ( Her Heart Is Broken) (Louisiana Swamp Man) (Songwriters) (Trainwreck) ( Fallen Heroes (9-11) and (Just Like Long Ago) which hit the mainstream chart on The Independent Music Network. 10/13/09 making it one of her 17 songs that made the chart in 2009/15 staying on the chart 7 months straight, It is still finding it's way back on the charts there (Her Heart Is Broken) co-written and produced by Nelson Blanchard, it was well received and hit # 13 first week of it's release on the Independent Music Network Country Chart and stayed on the chart for six months Straight.. Nelson also performed the vocals. Carmella co-wrote 8 songs with her Multi Talented Grammy Nominated Music Producer Nelson Blanchard (where would I be without Nelson) He is an amazing person as well as Musician). Their song titled "Fallen Heroes 9-11" was nominated for 'Song of the Year" by The Independent Country Music Association in April of 2012.. (The award that year went to Jimmy Fortune of the Statler Brothers ) Nelson is a Louisiana Hall Of Fame inductee with the great band Louisiana LeRoux.. and finally together with some help from Scott Innes (voice of Scooby Doo fame) and CMA award winner they released "Where Is Our Sea, Blue Shining Sea" a song about the Gulf Tragedy..which they Dedicated to all those who lost their lives, and all those affected by the BP Oil Spill ..Nelson co-wrote the song with Carmella and also performs the vocals Scott was Gracious enough to perform the intro to the song.. Carmella received the Female Songwriter of the Year award by CMG Radio International two years in a row, April 2013 and Sept, 2014, Nelson and Carmella also were awarded The Songwriting Team of the Year Award in April of 2013 and 2015..Carmella received both awards in Lebanon Tenn.. at The Teddy Bear Festival Hosted by The CMG Radio Network to raise money for The Vanderbilt Children's Hospital.. Carmella had also been nominated for Song of the Year 2012 and Songwriter of the Year 2014 by the Independent Country Music Association.. has also been nominated for Traditional Songwriter of the Year at Country Blast Radio 2015 and she took home the Award for Female Country Songwriters of the Year ( The Josie Music Awards ) held at The Shermerhorn Symphony Center in Nashville Tenn on Sept 18th 2016, Carmella was also Awarded Songwriter of the Year at Fishing Country Now + Cowgirl Divas Radio. One of the songs she co-wrote ( Homeless, Hungry, Crying (in the rain) hit The Independent Music Network Chart at #5 and stay on the chart for nine weeks straight in the top ten, Melodic Revolution Records-There Is Hope Records has chosen to release it on their Cd titled Musicians For Oil Relief. Money from it's sale helps those affected by the BP Gulf of Mexico Oil spill including it's wildlife. It has also been released on Songs Of Hope..a Cd for Charity to help Children with Disabilities, abused and neglected children..Carmella also Donated songs she wrote to.The Veteran Memorial Foundation and Disaster Relief U.S.A..Carmella and Nelson's Tribute Song + Video Fallen Heroes 9-11 has been posted by YouTube for there top 5Fifty 9-11 Tributes and it is posted by them in the #1 spot.. Her video (Homeless, Hungry, Crying in the rain ) made Twitters Cast T.V's video of the week first week out. Carmella has won 3 Suggested Artist Awards an Honorable Mention Award and 2 Runner-Up awards from Song of the Year. Carmella has received notification that her song (Just Like Long Ago) became Certified on Songvault.com, coming in at #1. Her song (Trainwreck) also became certified, along with "Her Heart Is Broken, Homeless, Hungry, Crying in the Rain and Just Like long Ago and Several more ..Carmella has just received another Song Of The Year Supporters of Vh1 Save The Music Suggested Artist Award, Nelson Blanchard has produced all of the song listed.Carmella has been featured on many of the music sites in which she is a member and her music can be hear on Internet Radio as well as Mainstream. One of Carmella's highlights of the year 2009 is when she attended the 51st Grammy Awards In LA with her music producer Nelson Blanchard . http://www.reverbnation.com/carmellainchierchiera Nominated for Song of the Year (Fallen Heroes) 9-11, in 2012 -The Independent Country Music Association Awarded Female Songwriter of The Year On Apr 28, 2013 - CMG Global Radio in Lebanon Tenn. Awarded Songwriting Team of the Year with Nelson Blanchard On Apr 28, 2013 CMG Global Radio in Lebanon Tenn. Awarded Female Songwriter of The Year in Sept. 2014 - CMG Global International Radio Nominated for Songwriter of the Year by The Independent Country Music Association May 2014 Awarded Songwriting Team of the Year with Nelson Blanchard in Sept. 2015- CMG Global International Radio Nominated for Traditional Songwriter of the Year at The Josie Music Awards 2015 Awarded Songwriter of the Year at Fishing Country Now + Cowgirl Divas Radio 2016 Awarded Female Country Songwriter of the Year The Josie Music Awards in Nashville Tenn. 2016 Awarded Songwriter of the Year at Fishing Country Now + Cowgirl Divas Radio 2017 Nominated for Songwriter of the Year ( All Bodies of Work ) The Josie Music Awards 2017 Awarded Rock/ClassicRock Song of the Year ( Mirror Mirror ) The Josie Music Awards 2017 In Nashville Tenn CMG Number One International Chart Artist On May 16, 2013 My Song ( Just Like Long Ago ) Performed/Produced by Nelson Facebook Friend of the Year On Apr 28, 2013 CMG Radio International's ( Facebook Friend of the Year) Award Songwriter of the Month In Feb 2013 from Scott + Roger's Round-Up Blog Talk Radio Fishing Country Now + Cowgirl Diva Radio Won Female Artist of the Month for September 2012 Cmg Radio Network In Jul 2012 #1 Chart Buster .."Fallen Heroes 9-11" Co-written with Nelson Blanchard Cmg Radio Network In 2012 #1 Chart Buster ( Her Heart is Broken) Co-written with Nelson Blanchard There is Hope Records Charity Released Cd Disaster Relief USA Donated My Song Just Like Long Ago in 2012 Veterans Memorial Foundation Charity released CD Welcome Home: Unsung Heroes Donated My Song Thrown Away Soldier 2012 There is Hope Records Charity Released Cd Musician for Oil Relief Donated My Song Homeless, Hungry, Crying in the Rain in 2010 Songs for Hope Charity Released Cd Donated my Song Homeless, Hungry, Crying in the Rain in 2009 CMG Radio International #1 Chart Buster with Just Like Long Ago. August 2012 Awarded The "I Like It" World Committee Track Award, Sept 2013 Fallen Heroes 9-11 Dj's Country Pic of the Year ( Songwriters ) - Co-Written with Nelson Blanchard CMG Global Radio 2014	cc/2020-05/en_middle_0111.json.gz/line2806
__label__wiki	0.988145	0.988145	D. Ross Cameron-USA TODAY Sports Sacramento parties as fans celebrate realization of Republic's MLS dream October 22, 20195:23PM EDT Tom BogertContributor Follow@ tombogert SACRAMENTO, Calif. – At just 6 years old, Ryan Mac is a passionate a supporter of the Sacramento Republic as you'll find. For as long as he can remember, he has spent game days cheering on his beloved hometown team and even defying his tender years, drum in hand, to lead a whole supporters' group, Tower Bridge Battalion. For as long as he can remember, he has also been waiting, hoping, that Sacramento's long journey to reach Major League Soccer would finally come to fruition. In downtown Sacramento on Monday, Ryan was there, banging his drum as ever. It was not a game day, though. Instead it was a celebration more important than any single 90 minutes. Ryan was walking around happy as can be with his dad, Mike, trailing behind, as father and son celebrated the announcement that MLS awarded an expansion team to their beloved club. The four years they had been waiting for this moment made it all the sweeter. It takes a Republic, as the club would proudly say. "He said 'Dad, I want to lead The Battalion,'" Mike told MLSsoccer.com on Monday from The Republic's Indomitable Block Party, taking over downtown Sacramento. "So, we got him a drum and he's been leading The Battalion for about a year now. He knows every chant, he loves it. He's fantastic. We've been following this club from the very first day to today, since he was a baby. He's grown up with the club." Ryan (right) celebrating in Sacramento on Monday \| USA Today Sports Mike and his son Ryan were two of many to attend festivities in Sacramento, all as the city celebrated their club winning an MLS expansion bid. The Block Party featured Republic fans from all walks of life coalescing for an evening of local food, beer, games and, most importantly, their club. Perhaps not all 6-year-olds in Sacramento are leading chants at Republic matches, but the larger point of Ryan and Mike Mac's story isn't unique. It's a community-based club and it was a celebration for the city. "It's super exciting, it means a whole new phase of growth for Sacramento," Elizabeth Zennadi said, with her own 4-year-old son Tristan smiling along. "Finally, it's happening, but I'm a Sacramento native so I never lost hope. It took some time, but I was confident in our leadership. I was confident we'd get it done." The process wasn't linear and it wasn't easy. They were one of 12 groups to submit an expansion application in January 2017, but saw Cincinnati, Nashville, Miami, St. Louis and Austin all confirmed as new MLS cities before their time arrived. They had come close, and MLS Commissioner Don Garber famously said "when, not if" Sacramento would be awarded a franchise. Then they finally got over the hump. On Monday's huge day, it drew Republic fans from all over the area. "I went to the first-ever home game they had. Once we got a team, I was so excited," said Ben, a 21-year-old student in Reno who made the 132-mile drive just to partake in the celebration. "I came back today just for this. This is a huge moment for the city, I just had to be here." Now, with their journey to winning an expansion bid behind them, Sacramento Republic look to take the next step. Expect Ryan to be there every step of the way, banging away at his drum. "We know what we have here is special, we have something the kids can look up to," Mike said. "We have something we can build on, we never wavered our hope." Faces of Sacramento: Meet the supporters behind Republic FC Sacramento Republic are ahead of other expansion sides in this department Why Sacramento's mayor was talking smack to mayors of San Jose, LA MLS & Republic brass react to expansion news: "You can feel the energy" Sacramento mayor ignites rivalry with LA, San Jose as Republic join MLS "Today is a day we were fighting for": Sacramento's long journey to MLS	cc/2020-05/en_middle_0111.json.gz/line2807
__label__wiki	0.911636	0.911636	Home Free Browser Games Free Browser Games 109 Free to play browser based games found! Embark on an epic quest to save world in League of Angels III, the latest entry in the free-to-play browser-based MMORPG franchise. Game of Thrones: Winter Is Coming Fame and glory await you in Westeros, in Game of Thrones: Winter Is Coming, the officially licensed free-to-play browser game based on the epic fantasy series by George R.R. Martin. The Third Age Embark on an epic tale of glory in The Third Age, a free-to-play browser MMORPG from R2 Games that evokes images of the most legendary of all fantasy worlds. Take your favorite SoulCalibur fighters into battle against unending waves of foes in this free-to-play action game from GameSprite. Travian is a phenomenon. Initially published in 2004, it today entertains millions of players worldwide. Now the timelessly popular game has been completely reworked: The graphics are all-new and more contemporary... Grand Prix Racing Online Guide your Formula One team to the championship in Grand Prix Racing Online, a highly detailed free-to-play racing simulator. Omega Zodiac Fight for the goddess Athena and earn amazing rewards in Omega Zodiac, a free-to-play browser-based action MMORPG from Proficient City and Game Hollywood. Awaken your inner dragon in Dragon Awaken, a free-to-play browser MMORPG where you take on the powers of a dragon to defend your kingdom! In InnoGames' Elvenar, you can build an epic fantasy city, populated by elves or humans, and watch it grow into a sprawling metropolis, awash in riches and brimming with military might. Forge of Empires is a browser-based MMORTS by InnoGames. Relive history as you rule over your empire through early human civilizations. Starting from the Stone Age and advancing to the Late Middle Ages, watch your empire progress through the ages. Manage your city, produce resources, and build an army to conquer surrounding providences. In Vikings: War of Clans, it's up to you to take on the challenge of managing your village, leading your warriors on raids, and becoming a jarl worthy of song! Become a devil hunter and challenge the forces of evil in Dark Knight, a free-to-play browser MMOARPG from Fortune Game Ltd. Vampire Empire The battle between vampires and werewolves goes back in time in R2 Games' free-to-play title Vampire Empire! Avast! Set sail and plunder the high seas in Ultimate Pirates, a web-based MMORPG from Gameforge and developer Moonmana. Starborne Build your space empire and conquer the galaxy in Starborne, a sci-fi free-to-play browser-based MMO strategy game from Solid Clouds. Eternal Fury Play a part in the battle between gods and giants in Eternal Fury, a free-to-play ARPG from R2 Games. Prosperous Universe Make your fortune and become an outer space tycoon in browser-based free-to-play economic simulation Prosperous Universe! Mad World is a free-to-play post-apocalyptic HTML5 MMORPG designed by Jandisoft with an emphasis on survival and portability. Star Trek: Alien Domain is a free-to-play sci-fi strategy game played in a web browser. The game features a new Star Trek story, dozens of new starships and alien species. Heroes Origin Take to the battlefield and lead your armies to victory in Heroes Origin, a free-to-play turn-based strategy game from Viva Games. Total Battle Reforge your legacy from the ashes in Total Battle, a free-to-play browser strategy game from Scorewarrior Ltd. Betrayed by your closest adviser, you start with just a ragtag army of your most loyal troops... World War Online Take on the world in World War Online, a free-to-play strategy browser game that puts you in command of a modern military arsenal. Become a superhero and fight for truth, justice, and the fanciest underpants in Hero Zero, a free-to-play browser-based MMORPG from Playata! Take part in an immersive multiplayer online fantasy world in Stein, a charming free-to-play social browser-based MMORPG from pg5-studio. CLIENT GAMES TCG/CCG 2D Browser Games733D Browser Games36	cc/2020-05/en_middle_0111.json.gz/line2808
__label__cc	0.603268	0.396732	When Lady Constantine awoke the next morning Swithin was nowhere to be seen. Before she was quite ready for breakfast she heard the key turn in the door, and felt startled, till she remembered that the comer could hardly be anybody but he. He brought a basket with provisions, an extra cup-and-saucer, and so on. In a short space of time the kettle began singing on the stove, and the morning meal was ready. The sweet resinous air from the firs blew in upon them as they sat at breakfast; the birds hopped round the door (which, somewhat riskily, they ventured to keep open); and at their elbow rose the lank column into an upper realm of sunlight, which only reached the cabin in fitful darts and flashes through the trees. 'I could be happy here for ever,' said she, clasping his hand. 'I wish I could never see my great gloomy house again, since I am not rich enough to throw it open, and live there as I ought to do. Poverty of this sort is not unpleasant at any rate. What are you thinking of?' 'I am thinking about my outing this morning. On reaching my grandmother's she was only a little surprised to see me. I was obliged to breakfast there, or appear to do so, to divert suspicion; and this food is supposed to be wanted for my dinner and supper. There will of course be no difficulty in my obtaining an ample supply for any length of time, as I can take what I like from the buttery without observation. But as I looked in my grandmother's face this morning, and saw her looking affectionately in mine, and thought how she had never concealed anything from me, and had always had my welfare at heart, I felt-that I should like to tell her what we have done.' 'O no,-please not, Swithin!' she exclaimed piteously. 'Very well,' he answered. 'On no consideration will I do so without your consent.' And no more was said on the matter. The morning was passed in applying wet rag and other remedies to the purple line on Viviette's cheek; and in the afternoon they set up the equatorial under the replaced dome, to have it in order for night observations. The evening was clear, dry, and remarkably cold by comparison with the daytime weather. After a frugal supper they replenished the stove with charcoal from the homestead, which they also burnt during the day,-an idea of Viviette's, that the smoke from a wood fire might not be seen more frequently than was consistent with the occasional occupation of the cabin by Swithin, as heretofore. At eight o'clock she insisted upon his ascending the tower for observations, in strict pursuance of the idea on which their marriage had been based, namely, that of restoring regularity to his studies. The sky had a new and startling beauty that night. A broad, fluctuating, semicircular arch of vivid white light spanned the northern quarter of the heavens, reaching from the horizon to the star Eta in the Greater Bear. It was the Aurora Borealis, just risen up for the winter season out of the freezing seas of the north, where every autumn vapour was now undergoing rapid congelation. 'O, let us sit and look at it!' she said; and they turned their backs upon the equatorial and the southern glories of the heavens to this new beauty in a quarter which they seldom contemplated. The lustre of the fixed stars was diminished to a sort of blueness. Little by little the arch grew higher against the dark void, like the form of the Spirit-maiden in the shades of Glenfinlas, till its crown drew near the zenith, and threw a tissue over the whole waggon and horses of the great northern constellation. Brilliant shafts radiated from the convexity of the arch, coming and going silently. The temperature fell, and Lady Constantine drew her wrap more closely around her. 'We'll go down,' said Swithin. 'The cabin is beautifully warm. Why should we try to observe to-night? Indeed, we cannot; the Aurora light overpowers everything.' 'Very well. To-morrow night there will be no interruption. I shall be gone.' 'You leave me to-morrow, Viviette?' 'Yes; to-morrow morning.' The truth was that, with the progress of the hours and days, the conviction had been borne in upon Viviette more and more forcibly that not for kingdoms and principalities could she afford to risk the discovery of her presence here by any living soul. 'But let me see your face, dearest,' he said. 'I don't think it will be safe for you to meet your brother yet.' As it was too dark to see her face on the summit where they sat they descended the winding staircase, and in the cabin Swithin examined the damaged cheek. The line, though so far attenuated as not to be observable by any one but a close observer, had not quite disappeared. But in consequence of her reiterated and almost tearful anxiety to go, and as there was a strong probability that her brother had left the house, Swithin decided to call at Welland next morning, and reconnoitre with a view to her return. Locking her in he crossed the dewy stubble into the park. The house was silent and deserted; and only one tall stalk of smoke ascended from the chimneys. Notwithstanding that the hour was nearly nine he knocked at the door. 'Is Lady Constantine at home?' asked Swithin, with a disingenuousness now habitual, yet unknown to him six months before. 'No, Mr. St. Cleeve; my lady has not returned from Bath. We expect her every day.' 'Nobody staying in the house?' 'My lady's brother has been here; but he is gone on to Budmouth. He will come again in two or three weeks, I understand.' This was enough. Swithin said he would call again, and returned to the cabin, where, waking Viviette, who was not by nature an early riser, he waited on the column till she was ready to breakfast. When this had been shared they prepared to start. A long walk was before them. Warborne station lay five miles distant, and the next station above that nine miles. They were bound for the latter; their plan being that she should there take the train to the junction where the whip accident had occurred, claim her luggage, and return with it to Warborne, as if from Bath. The morning was cool and the walk not wearisome. When once they had left behind the stubble-field of their environment and the parish of Welland, they sauntered on comfortably, Lady Constantine's spirits rising as she withdrew further from danger. They parted by a little brook, about half a mile from the station; Swithin to return to Welland by the way he had come. Lady Constantine telegraphed from the junction to Warborne for a carriage to be in readiness to meet her on her arrival; and then, waiting for the down train, she travelled smoothly home, reaching Welland House about five minutes sooner than Swithin reached the column hard by, after footing it all the way from where they had parted.	cc/2020-05/en_middle_0111.json.gz/line2810
__label__wiki	0.844755	0.844755	Legs & Regs Congress Opens Campaign Against Domestic Terrorist Financing Rep. Emanuel Cleaver (D-MO)., speaks at the Democratic National Convention in Philadelphia on Thursday, July 28, 2016. On Wednesday, Jan. 15, 2020, Cleaver chaired a congressional hearing on violent domestic extremists and their sources of funds. (CQ Roll Call) HM Treasury Publishes Updated Version of Asset Freeze Sanctions List HM Treasury modified its Consolidated List of Financial Sanctions Targets in the United Kingdom, which contains the names of designated individuals and entities subject to international asset freezing and domestic sanctions under the Terrorist Asset-Freezing etc. Act 2010. HM Treasury Issues Notice Updating Terrorist Financing Designation HM Treasury’s Office of Financial Sanctions Implementation issued a notice concerning amendments to a designated individual on its terrorism and terrorist financing sanctions list following changes to Council Regulation (EC) No 2580/2001 to reflect the death of Qasem Soleimani. HM Treasury Removes 15 Entries from Iraq Sanctions List HM Treasury’s Office of Financial Sanctions Implementation issued a notice concerning the removal of 15 entities from the consolidated list following amendments to Council Regulation (EC) 1210/2003, which imposes financial sanctions against Iraq. HMT Renews Two Designations Under Anti-Terrorism, Crime Legislation HM Treasury’s Office of Financial Sanctions Implementation published a notice covering the renewal of two designations under the Anti-terrorism, Crime and Security Act 2001, resulting in the issuance of freezing orders with effect from Jan. 18, 2020. Test Your AML IQ Financial Crime Matters: Real Estate Money Laundering in Canada with Maureen Maloney In this episode of Financial Crime Matters, Kieran Beer, editor in chief of ACAMS moneylaundering.com, interviews Maureen Maloney, a professor of Public Policy at Simon Fraser University. They discuss her work investigating money laundering in British Columbia’s real estate sector. How many enforcement actions did the Financial Crimes Enforcement Network levy in 2019? A. One. B. Two. C. Four. D. None. By : Kieran Beer Weekly Roundup: Danske Bank Probe Expands, UN Declares North Korean Cryptocurrency Conference Off Limits, and More ING loses enforcement-action appeal, PayPal to cooperate with anti-trafficking group, and more, in the weekly roundup. Legal Brief: US Officials Target Corruption in Latin America By : Laura Cruz, moneylaundering.com legal editor In the 10th installment of our series, the moneylaundering.com legal team covers U.S. efforts against corruption in Latin America. US Asset Forfeiture Tool of ‘Last Resort’ Now in Play Against Chinese Banks: Sources By : Daniel Bethencourt By : Valentina Pasquali FTC: SIA Transact Pro, Former CEO to Pay $3.5 Million in Connection with Alleged Credit Card Laundering The Federal Trade Commission entered into a stipulated order with the Riga, Latvia-based financial institution and its former CEO Mark Moskvins requiring them to pay a $3.5 million judgment, refrain from engaging in credit card laundering and properly screen prospective high risk clients. DOJ Issues Addendum to 2016 NPA Requiring Union Bancaire Privée, UBP SA to Pay Additional $14 Million The U.S. Justice Department issued an addendum to a Jan. 6, 2016 non-prosecution agreement with the Geneva, Switzerland-based financial institution that requires the bank to pay an additional $14 million for failing to originally disclose all U.S.-related accounts under the Swiss Bank Program. Fed, Texas Regulator Order United Bank of El Paso del Norte to Address AML/BSA Deficiencies South African Reserve Bank Penalizes Five Banks for AML Violations DOJ: Addendum to Swiss Bank Program NPA Requires Coutts & Co Ltd. to Pay Additional $27.9 Million '); $('#content').html(' '); $('#content').load(link + ' #contentInner', function () { }); //$('#content').animate({left: '250px'}); }); © 2019 Association of Certified Anti-Money Laundering Specialists LLC. All Rights Reserved Terms of UsePrivacyLegalCookie PolicyCookie Preference Center	cc/2020-05/en_middle_0111.json.gz/line2811
__label__wiki	0.589717	0.589717	Morocco-UK Consolidate Business Ties with New Working Group Home News International News Prospective US Senator Calls Islam ‘Contradictory’ to American Constitution Prospective US Senator Calls Islam ‘Contradictory’ to American Constitution By Ghita El Hafidi Photo Credit: REUTERS/Bob Ealum Rabat – United States Republican politician and former judge Roy Moore has taken public Islamophobia in the country to new levels, telling voters that Islam is a “false religion.” Former Alabama Supreme Court chief justice, Roy Moore, currently running to the state’s senate seat, made the comment during a meeting of the Republican club in Gardendale, Alabama last Tuesday, reports HuffPost. The Republican’s statement, captured in a video published on his Facebook page, followed a question by a woman at the North Jefferson Country meeting about Sharia law. “I’ve seen a lot in the news about Sharia law, and Muslims demanding break times to do their prayers and wanting to have their laws oversee our laws,” says the woman, referring to the conspiracy theory that implies that Islamic law is a threat to the US judicial system. “I just wonder how you plan to deal with that.” “False religions like Islam,” alleges Moore in his reply, “that teach you to worship this way, are completely opposite with what our First Amendment stands for.” The First Amendment of the US constitution states that “Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof.” According to members of the Council on American-Islamic Relations (CAIR), the Moore’s extremist stance on Islam at the meeting was not surprising. “Moore had a long history of extremist attitudes,” affirmed Corey Saylor, a spokesman for (CAIR). “It is more disappointing that his statement went unchallenged in the room.” Many Americans fear that Sharia law is “taking over,” despite the statistics showing that Muslims make up roughly 1 percent of the US population, just 3.3 million. Moore is nationally known for having been removed twice from the bench as an Alabama state judge after making two “mistakes.” First, he banned same-sex marriage while US Supreme Court legalized it, and second, he refused to remove a monument of Ten Commandments installed at the Alabama courthouse. Moore’s comments come as just one of many Islamophobic statements made publically by US politicians. In January, a number of people accused Linda Sarsour – a Muslim activist who was one of the organizers of the Women’s March on Washington – of turning the demonstration into a “secret” “Sharia march.” Dutch MP Geert Wilders Ridicules Islam with Prophet Caricature Contest Moroccan NGO Organizes Conference on Islamophobia in Spain Muslim Woman Confronts Man for Anti-Semitic Abuse in London Man Viciously Assaults 8-Months Pregnant Muslim Woman in Australia Muslims, Activists in France Want to March Against Islamophobia Macron: Hijab in Public Spaces is ‘None of My Business’	cc/2020-05/en_middle_0111.json.gz/line2815
__label__cc	0.711658	0.288342	Home / News / Modified 1972 Porsche 914 Truck: The World's Only Mid-Engine Pickup? John Voelcker August 18, 2013 Comment Now! Tens of millions of pickup trucks have engines in the front. Then there are the ones with engines in the rear (think Volkswagen Type 2 pickups, for instance). But have you ever seen one with an engine in the middle? This 1972 Porsche 914 pickup truck is most likely one of the only two in the world. Now owned by Myron Vernis of Akron, Ohio, it was converted during the 1970s by famed southern California coachbuilding firm Troutman & Barnes, perhaps best known for building the Scarab Grand Prix and Le Mans cars of the late 1950s and early 1960s. According to Vernis, the company built one for itself, and a second one for Aase Brothers Porsche, a parts and wrecking business in Anaheim, California. It appears that Troutman (or Barnes) bought a wrecked Porsche 914-6 from the firm, and mentioned to Dave Aase that he planned to turn it into a pickup truck. Aase asked if he would turn another 914 they had--the less-powerful four-cylinder 914-4 model--into a second pickup at the same time, and the deal was done. The taillights, by the way, are from an Opel Manta. The wrecking business used it as a shop truck and parts transporter, and the 914 pickup was featured in VW Trends magazine with with adult entertainer Renee Vaughn posing on the car. At that time, it was painted brown, with the business advertised on the rear quarters. That's the car that Vernis has now--since repainted red--which he'd pursued for 15 years and has only owned since June. That's not all he owns, either; he suffers from what he delicately terms the "disease" of collecting rare car-based pickup trucks. He also has, for instance, a Ford Durango. That's a pickup made in 1980 and 1981 from a Ford Fairmont coupe, one of 212 built by National Coach of Los Angeles, with Ford's authorization as a replacement for the discontinued Ranchero. The Durango's engine, however, is in the usual place. The 914 pickup? Not so much. You can see photos of the Troutman & Barnes Porsche 914-6 pickup, now owned by Kevin Jeannette of Gunnar Racing, here. Fun Stuff Modified Porsche News Sports Cars Galpin Teases Its Ford GT-Inspired GTR-1 Supercar Production Porsche 918 Spyder Shows Up At Pebble Beach Saleen Unveils Heritage Collection Camaro, Challenger And Mustang Lamborghini’s Oldest And Newest Cars Head To Pebble Beach Pair of Rtech's massive restomod Chevy pickups visit Jay Leno's Garage Modified January 21, 2020 2020 Chevrolet Corvette C8 VIN 001 sold to Rick Hendrick for $3M Sports Cars January 20, 2020 Next-generation Nissan Z reportedly has 400 hp, retro design Sports Cars January 19, 2020 Morgan Plus 4 celebrates 70 years, leaves production with gold special... Sports Cars January 17, 2020	cc/2020-05/en_middle_0111.json.gz/line2816
__label__wiki	0.560119	0.560119	Serving machinery and equipment maintenance professionals across Canada Dana completes purchase of Brevini power-transmission, fluid power businesses Machinery and Equipment Maintenance The combination of Brevini and Dana Off-Highway creates a formidable player in the market with complementary, advanced technologies. Maumee, Ohio – Dana Incorporated announced that it has completed the acquisition of the power-transmission and fluid power businesses of Brevini Group, S.p.A. The combination of Brevini into Dana’s business creates numerous opportunities for profitable growth. Among them, the acquisition: – immediately expands Dana’s product portfolio and establishes the company as the only solutions provider that can manage power conveyance to move machines and also perform the work functions of the machine; – increases Dana’s addressable market for off-highway driveline systems by providing access to tracked vehicles in that segment; – significantly broadens the opportunities in industrial markets – an important segment that Dana has served for more than 70 years; – provides a platform of proven technologies that can be offered to Dana’s on-highway customers; and – accelerates Dana’s hybridization and electrification initiatives. “Brevini is a company we have long admired. It is a strong, well-run business that shares Dana’s commitment to serving customers with advanced technologies that deliver exceptional performance and durability,” said James Kamsickas, president and chief executive officer of Dana. “Brevini’s product line is a perfect complement to Dana’s current offerings, which is why we executed this transaction at an opportune time in the off-highway business cycle.” The acquisition of Brevini aligns with Dana’s enterprise strategy, which includes leveraging core expertise, strengthening customer centricity, expanding global markets, commercializing new technologies, and accelerating hybridization and electrification. Dana purchased an 80 per cent share in the Brevini businesses, with an option to purchase the remaining 20 per cent by 2020. Dana has valued 100 per cent of the Brevini businesses at €325 million, including the assumption of approximately €100 million of net debt. The transaction was funded with cash on hand. Founded in 1960, the privately held Brevini Group includes approximately 2,300 people. It has major engineering and manufacturing operations in China, Germany, and Italy, with a network of 30 sales subsidiaries and nine service centers around the world. The businesses being acquired reported sales of €388 million in 2015. “Brevini’s customers and employees will find an ideal fit with Dana, a company that delivers true value to customers through a commitment to innovation,” said Renato Brevini, president of Brevini Group. “Dana’s global footprint, operational excellence, deep knowledge of the vehicular and industrial markets, and position as a top-tier supplier to manufacturers will raise the profile and market penetration of our products.” Brevini technologies purchased by Dana include a wide range of highly engineered mobile planetary hub drives; planetary gearboxes; hydraulic pumps, motors, and valves; and advanced electronic control systems. Brevini’s expertise in cylindrical gearing and planetary hub gears will supplement Dana’s long history and market leadership in spiral bevel and hypoid gear technologies. Brevini’s technology portfolio increases the patents and patents pending for Dana’s off-highway business by 33 percent. “Brevini’s product portfolios will help us to increase Dana content on construction, mining, material-handling, and other off-highway equipment,” said Aziz Aghili, president of Dana Off-Highway Drive and Motion Technologies. At the same time, it expands our opportunities in the industrial market, which has been an important sector for Dana for nearly three quarters of a century.” With the completion of this transaction, Brevini financial results will be included in the Off-Highway Drive and Motion Technologies segment, which was previously named Off-Highway Drivetrain Technologies. Garlock Bearings to acquire industrial polymer bearings business from Dana International power transmission/fluid power expo set to open in March Emerson to sell power transmission solutions business to Regal Beloit Timken completes acquisition of belts business SKF destroys 15 tons of fake bearings Material handling segment is expected to lead the global market, report	cc/2020-05/en_middle_0111.json.gz/line2820
__label__cc	0.647013	0.352987	Lathrop High School Activity Listing Lathrop State Records Scoreboard Scoreboard Map Activity Listing Opponent Search 2019-2020 Lathrop High School 11-Man Football Class 2 District 8 Help Hide This is the list of all of your currently scheduled Games for Football - 11 Man. Here is what you need to know about this page: Home Games appear in bold. Opponent School Name: Clicking on the opponent school name will take you to the competition, where you will be able to edit, postpone, reschedule, cancel, or delete. Scores: Starting on the day of the competition, you will be able to enter the score by clicking on "Add" in the score column. You may edit any score already entered by simply clicking on the score. Pitch Counts: The baseball icon shows the status of the pitch counts for each game. Green indicates that counts have been entered for all levels of play. Orange indicates that pitch counts have been entered, but not for every level of play. Red indicates that no pitch counts have been entered. The icon will be gray for canceled games and games that have yet to occur, since we don't believe you can predict the future, at least in regard to how many pitches will be thrown. Line Ups: The tennis icon will take you to the Line Ups page where you can view and update your Line Ups and also view the Line Ups of your opponent. A green check mark in the singles (SGL) or doubles (DBLS) columns indicate the completion of the line ups. Competition Contracts: This document icon identifies Games which are part of a Competition Contract with another school. If a contract exists, the icon will be green, and clicking on the icon will take you to that contract. If no contract currently exists and the Game is in the future, the icon will be gray, and clicking on it will give you the ability to create a contract for it. Officials: The user icon refers to contracted officials. If there are no contracts, the icon will be gray. If there are contracts, the icon color will depend on the status of the contracts. Clicking on the icon will reveal any contracts that have been issued, along with their status. Clicking on the user icon at the very top will show and hide all Official Contrats. Levels of Play: This icon is for the Levels of Play. Clicking on this will reveal details for each level associated with the Game. Clicking on the icon at the very top will show and hide all Levels of Play. Varsity V Junior Varsity JV 2024-2025 2023-2024 2022-2023 2021-2022 2020-2021 2019-2020 2018-2019 2017-2018 2016-2017 2015-2016 2014-2015 2013-2014 2012-2013 2011-2012 2010-2011 2009-2010 2008-2009 2007-2008 2006-2007 2005-2006 Varsity Season Record: (13-1)Junior Varsity Season Record: (1-0) View Football Points Date Competition Levels Outcome Score 8/30 at Trenton Varsity 7:00 PM Win 42 - 14 9/2 at Trenton Junior Varsity 5:00 PM 9/6 Hogan Prep Academy Charter Varsity 7:00 PM Win 50 - 6 9/13 at Mid-Buchanan Junior Varsity 5:00 PM Win 42 - 0 9/20 Penney 9/27 at West Platte 10/4 at Lawson 10/11 North Platte 10/18 Plattsburg 10/25 at East Buchanan 10/28 at Brookfield 11/1-12/6 Class 2 - State Tournament 11/1 Trenton 11/8 Richmond 11/15 Maryville 11/23 Summit Christian Academy 11/30 Lutheran North Varsity 1:00 PM Loss 24 - 38 Varsity Football Points Schedule (13-1) Hide Football Points Result School Points Strength of Schedule Date Competition Outcome Score Play Up Pts Spread W L OTL Pts PPG 8/30 Trenton Class 2 Win 42 - 14 0 20 13 2 6 0 100 12.5 9/6 Hogan Prep Academy Charter Class 2 Win 50 - 6 0 20 13 6 1 0 130 18.57 9/13 Mid-Buchanan Class 1 Win 49 - 0 0 20 13 8 0 0 160 20 9/20 Penney Class 1 Win 49 - 13 0 20 13 4 4 0 120 15 9/27 West Platte Class 1 Win 47 - 0 0 20 13 1 7 0 90 11.25 10/4 Lawson Class 2 Win 38 - 13 0 20 13 6 2 0 140 17.5 10/11 North Platte Class 1 Win 69 - 6 0 20 13 3 5 0 110 13.75 10/18 Plattsburg Class 1 Win 61 - 0 0 20 13 4 4 0 120 15 10/25 East Buchanan Class 1 Win 56 - 12 0 20 13 3 5 0 110 13.75 0 20 13 37 34 0 1080 15.21 District Standings Seed Team Record Points Next Opponent Next Game 1 Maryville 7-1 56.42 2 Lathrop 9-0 48.21 3 Richmond 6-3 39 4 Lawson 6-3 36.89 5 Lexington 5-4 34.69 6 Brookfield 2-7 22.47 7 Trenton 2-7 21.63 8 St. Joseph Christian with Northland Christian 0-7 14.09	cc/2020-05/en_middle_0111.json.gz/line2821
__label__cc	0.551473	0.448527	UPDATE on Closures at Arkansas Boat Ramps and Recreational Areas Vicksburg, Miss –The Vicksburg District of the U.S. Army Corps of Engineers (Corps) has closed some High Water Closes Boat Ramps and Recreational Areas Vicksburg, Miss –The Vicksburg District of the U.S. Army Corps of Engineers (Corps) have closed boat Grand Ecore Visitors Center Gets New Volunteer Staffing Vicksburg, Miss –The Vicksburg District of the Corps of Engineers (Corps) and the Wendell Wilson Corps of Engineers Offers Free Boat Safety Inspections Vicksburg, Miss...The U. S. Army Corps of Engineers (Corps) Vicksburg District’s Louisiana Field The Vicksburg District Prepares for 2013 Hurricane Season Vicksburg, Miss – The National Oceanic and Atmospheric Administration’s (NOAA) Climate Prediction Riverton Beach Re-Opens for Summer Visitors Vicksburg, Miss…The Louisiana Field Office (LFO) of the Corps of Engineers Vicksburg District will Sardis, Miss… The U.S. Army Corps of Engineers Vicksburg District (Corps), the Mississippi Corps Invites Media Outlets to Riverton Beach Preparations VICKSBURG, Miss… The U.S. Army Corps of Engineers Vicksburg District’s Louisiana Field Office (LFO) Ward Returns From Afghanistan Vicksburg, Miss…Dennis Ward, contracts representative with the U.S. Army Corps of Engineers, National Safe Boating Week Being Observed at Corps Lakes VICKSBURG, Miss…National Safe Boating Week is May 18-24 at all Corps lakes. This coincides with the	cc/2020-05/en_middle_0111.json.gz/line2824
__label__cc	0.69841	0.30159	Malcolm's Malcolm Reeves's Ads from Hobart Tasmania Metro @ Malcolm's Adpost Malcolm's Adpost Profile of ochrerecruitment Name: Malcolm Reeves Tasmania > Hobart Metro Member since: Mar 01, 2018 Seize Opportunities in Locum Medical Jobs Australia - Ochre Recruitment - Ochre Recruitment is one of the best consultants in providing Job opportunities for qualified Doctors and Nurses. We recruit qualified candidates for Anaesthetics, Emergency medicine, General practice, surgery, medical administration, obstetrics and psychiatry for permanent & locum medical jobs in Australia. We are always on the lookout for quality medical practitioners. For details visit our website https://www.ochrerecruitment.com.au/ or make a call to 03 6224 4399. Contact Details: Level 12, 39 Murray Street, Hobart, TAS, Australia, 7000. JOB OFFERED: Ochre Recruitment For Locum Doctor Jobs in Australia - Ochre Recruitment - If you’re looking for a locum doctor jobs in Australia, Ochre Recruitment can help. Whether you are seeking a permanent or locum position, Ochre Recruitment is the medical recruitment experts who can find you the right medical jobs, in the right location, with the right benefits! To learn more, contact us at 03 6224 4399 or visit https://www.ochrerecruitment.com.au/doctors Contact Details: Level 12, 39 Murray Street, Hobart, TAS, Australia, 7000. Full-Time Permanen.. Locum Doctor Jobs Australia - Take Your Career to Next Level - Ochre Recruitment, the medical recruitment expert offers help in finding Locum Doctor Jobs Australia. We create an amazing opportunity for doctors in the position of Anaesthetics, Emergency Medicine, General Practice, Intensive Care, Obstetrics & Gynaecology, Paediatrics and much more. Our consultants offer full support in attaining a perfect job that satisfies your personal and professional needs. Call us at +61362244399 or visit https://www.ochrerecruitment.com.au/doctors for further details. Contact Details: Level 12, 39 Murray Street, Hobart, TAS, Australia, 7000. Esteemed Locum Doctor Jobs in Australia - Ochre Recruitment - Are you looking for Locum Doctor Jobs in Australia? Ochre Recruitment will help you find the perfect job that meets your lifestyle needs. For over 15 years as a reputable recruiting agency, we have established a relationship with many medical practices & hospitals. We are recently recruiting for the positions of Anaesthetics, Emergency Medicine, General Practitioner and Surgery. Contact us through +61362244399 or visit https://www.ochrerecruitment.com.au/doctors to make your registration. Contact Details: Level 12, 39 Murray Street, Hobart, TAS, Australia, 7000. Explore General Surgery Jobs in Australia with Ochre Recruitment - Ochre Recruitment a leading recruiting agency helps you find the right medical career that suits your needs. If you are looking for general surgery jobs, then we are here to recruit you for the position of maxillofacial & orthopaedic surgeon, locum & consultant surgeon, otolaryngologist and much more. With 15 years of experience, we have been offering an expert recruiting service in filling various job positions. Call+6448943320 or visit https://www.ochrerecruitment.com.au/disciplines/surgery now! Contact Details: Level 12, 39 Murray Street, Hobart, TAS, Australia, 7000. Are You Looking For Locum Medical Jobs In Australia? - Ochre Recruitment has been placing doctors into various positions for over 15 years. We aim to help doctors to find a suitable job according to their expectation. Whether you are seeking a permanent or locum position, we are the medical recruitment experts in Australia who can find you the right medical jobs in the right location with all benefits. Visit https://www.ochrerecruitment.com.au and register your details today. Contact Details: Level 12, 39 Murray Street, Hobart, TAS, Australia, 7000. Emergency Medicine Jobs in Australia - Ochre Recruitment - Whether you are seeking a permanent or locum position, Ochre are the medical recruitment experts who can find you the right medical jobs, in the right location, with the right benefits! Established by doctors, for doctors, we are proud of our long-running reputation for finding doctors for those emergency medicine jobs which have previously been difficult to fill. Register your details today, call us at 03 6224 4399 or visit https://www.ochrerecruitment.com.au/jobs Contact Details: Level 12, 39 Murray Street, Hobart, TAS, Australia 7000 Ochre Recruitmen.. Malcolm's Adpost has been viewed 16 times Malcolm Reeves's Ads from Hobart Tasmania Metro	cc/2020-05/en_middle_0111.json.gz/line2826
__label__cc	0.705305	0.294695	Nerdophiles Recap Therese Lacson TV Uncategorized Crisis On Infinite Earths Part Three: A Treadmill, Some Paragons, and The Devil Therese Lacson I’ll admit that this Crisis On Infinite Earths crossover hasn’t been perfect. Every moment is jam-packed and overflowing just due to the sheer size of the crossover, and yet, that’s exactly how I like it. Gone are the long-winded fight sequences and unnecessary flashbacks. And for a cliffhanger, Part Three certainly left me cursing The CW for splitting the crossover apart into two parts. So far, the crossover cameo game has been strong. From Kevin Conroy’s full role as old man Batman to shots of Walter Curran as Titans’ Jason Todd, we’ve been loving getting confirmation after confirmation of all the different universes that belong to our favorite DC media iteration. Tonight kicked off with a shot of Ashley Scott from the short-lived 2002 WB series Birds of Prey, aka one of the most formative shows in yours truly’s childhood as far as superhero tv shows go. Yes, it wasn’t perfect, but getting to see Helena Kyle running across the rooftops of New Gotham in Earth-203 made my heart sing before we saw her world get taken out by the anti-matter wave. Damn you, Anti Monitor. You and your shitty name and your even shittier cannon. With the wave killing more and more universes by the minute, which also includes not just earth but millions of other alien planets also filled with life, it’s up to the heroes to work faster than ever to get to the remaining three paragons. Except, the joke’s on you guys, there’s just only one more paragon left! Either a part of the Monitor’s plan all along or simply an oversight due to the dwindling of his powers, turns out Barry and J’onn are both paragons. Barry is the Paragon of Love (awww), and J’onn is the Paragon of Honor. The final paragon, the Paragon of Humanity is someone named Ryan Choi (Osric Chau). Yes, everyone. It’s my baby, my sweet, sweet Asian one-day superhero. Ryan Choi, for the uninitiated, is one of the few to don the mantle of the Atom. In the comics, he is an immigrant from Hong Kong and a protege of Ray Palmer, which makes his first fanboy meeting of Ray that much more precious. So, as per the last two episodes, the teams break off. Now that Team Flash is in the house, we can add Cisco (Carlos Valdes), Caitlin (Danielle Panabaker), and Ralph (Hartley Sawyer) to the party. Ray, Ralph, and Iris go off to Ivy Town in search of Ryan as a part of Team Baby Atom. Cisco, confronted by the Monitor in a hallway, is forcibly given his powers as The Vibe back before he and Caitlin and Barry go off in search of the door that Nash Wells opened beneath Central City. The same door that turned him into Pariah and awakened the Anti Monitor. Due to the membership, we’ll just call them Team Flash. Finally, there’s Team We-Just-Can’t-Let-Oliver-Die-In-Peace. Now including Diggle (David Ramsey) in the gang, Mia, Diggle, Sara, and Constantine have to hope that they can somehow find Oliver’s soul in Purgatory so that the resurrected Oliver back on the Waverider can stop just being a killing machine. So, where to start? Well, let’s start from the potentially least significant plot point. Team Bring-Back-Oliver. Sigh, what to say about them? Well, they sure are persistent, that’s to be sure. And somehow they managed to rope Diggle into their mission as well. But somehow my least favorite plotline immediately became my favorite as the gang journeyed to Earth-666 to meet with the Devil (Tom Ellis)! That’s right, people! LUCIFER MORNINGSTAR! Seeing as the final season is so far away from airing, and technically in the Lucifer timeline, our Prince of Darkness is back ruling hell, it’s still quite nice to see old Luci back in action on our screens. Sweeping in with the same joie de vivre that he always exudes, he offers Constantine a card that will send them to Purgatory and bring them back once the image fades. We don’t spend enough time with our favorite fallen angel, because it’s off to Purgatory. And… yep, we’re back on this god damned island. Don’t forget, people, Lian Yu means Purgatory in Mandarin. I see the showrunners have been playing the long game with this one. Well, the team is on a clock as they scour the tiny-but-somehow-giant island for Oliver’s soul, but just as they find Oliver and he and Diggle have a brief but bittersweet moment, we are introduced to The Spectre aka Jim Corrigan (Stephen Lobo), who endows Oliver’s soul with near god-like powers. He’s the key to defeating the Anti-Monitor, but before we can find out any more, Lucifer’s image fades on the card and the gang is transported back to the Waverider. Then, we have Team Flash (sans Iris and Ralph). Cisco manages to vibe how to get into the underground lair after using his newly restored powers on Pariah aka Nash Wells. Remember, any time this guy is around, there’s a tragedy to be found. Getting into the lair, they see the machine that is perpetuating the anti-matter wave. It’s a cannon that is powered by a speedster. Earth-90’s Flash (John Wesley Shipp)! Yeah, after getting wooshed away by the Monitor last crossover, he was picked up by the Anti Monitor to use as a human battery to power his weapon that will clean out all the universes, allowing the Anti Monitor to have his own. Obviously not content to let their friend be used to destroy the universes, the team gets old man Flash off the treadmill. But all is not well. Without him running, the Anti Monitor’s programmed the cannon to and kill all of the worlds in an instant. Arriving just in time, Black Lightning aka Jefferson Pierce (Cress Williams) is wooshed onto Earth-1, thanks to Pariah. Although he’s initially distraught and reasonably shocked by the idea that he just lost his entire family and his entire world, he is quick to use his own abilities to hold off the cannon from killing them all as Barry and old man Flash go into Flashtime to try and figure something out. The two Flashes realize that to stop the cannon, they need to run backward on the treadmill to destroy the machine. But before Barry can jump on the treadmill, old man Flash steals his speed in order to make the ultimate sacrifice. Flash episodes always end up making me cry, and this was no different. Seeing the man who looks identical to his father, and someone who has acted as a mentor and a friend to him over the years, jump on the treadmill to sacrifice himself to save the universes? It’s enough to make anyone misty-eyed. With a final flashback to the 1990’s The Flash series, we see a past Barry with his lightning rod, Tina McGee (Amanda Pays), before old man Flash sacrifices himself to save the world. Team Flash and Team Oliver arrive back on the Waverider, the weapon destroyed, but still having suffered loss all over again. Thankfully Team Baby Atom was far more successful. Initially, with the idea of the world ending, Ryan Choi did what most of us would have done. He packed his bags and left work early in order to be with his wife and son. He admits outright that he’s no superhero and that he’s not the one they’re looking for, he needs to be with his family. Cue the quarterback and heart of the team (and another scene that made me cry): Iris West. She comes to appeal to Ryan. She appeals to his heart rather than any sense of duty. She tells him that humans are the ones who remind superheroes what they’re fighting for. And in a flashback to just before the teams split up to go on their missions, we see our OTP, Barry and Iris, saying goodbye, potentially for the last time. Honestly, these two are so often the heart of The Flash that I’m surprised they don’t share the mantle of Paragon of Love together. Afraid that this will be the last time they’ll see each other, Iris wants what Ryan Choi wants, she wants to go with Barry so that she’s with him until the end. But Barry sees the value that Iris presents. “I may be the one with superpowers, but your intelligence, your resourcefulness, your heart, that’s your superpower and that’s what’s going to help you convince Ryan Choi to be the hero he needs to be,” he says, as he kisses her and tells her that he will always run home to her, no matter what. (Yes, I was openly weeping by this point.) Iris’ superpower worked perfectly, and Team Baby Atom return back to the Waverider with Ryan Choi. Meanwhile, on the ship, Lois has been monitoring the worlds as they disappear, while J’onn and Routh-Superman try to evacuate any of the other earths before they’re destroyed. The scenes on the ship, though brief, held enough weight to leave a satisfying ache in the chest. We get a little insight into the Monitor as he recalls his own family to Lois and we see a flicker of humanity within the normally stoic being as he notes that he cared more about saving the universe than saving his family. The whole crossover reeks of this theme of sacrifice. That heroes must not only hold the ones they love close in their hearts but be willing to lose them or lose themself in order to save the billions of other people. It’s that determination to save every last bit of humanity that has Routh-Clark, a man who has lost everything, continue to go back to nearly-destroyed earths in order to save anyone he can. The same can be said for Kara. Ah, you thought I forgot about Team D? No. For those who haven’t been reading my recaps, Team D is the leftover team on the ground, normally relegated to doing menial tasks, but this time it included many of the main paragons. Left on the ship, Kara struggles with the desire to use the Book Of Destiny to bring back Earth-38. Knowing that it might leave her mind completely destroyed (thanks to some knowledge drop from Lex Luthor) she still is determined to save her planet. Kate, realizing the bigger picture, fears that she may have to stop Kara, by any means necessary, from doing this because she is one of the seven Paragons. Despite the precariousness of her possession of kryptonite (remember that that was kind of a dealbreaker for Kara’s friendship with Lena), the two women reconcile even after Kate reveals that she has it, and decide to rely on hope and courage rather than fear and doubt. Unfortunately, this is not the end, but just past halfway. And what’s a halfway point without a climax? Just as everyone reconvenes to figure out next steps Lyla appears. Except Harbinger is now the Anti-Monitor. The team figures it out a second too late, as he brings back the anti-matter wave easily and it destroys Earth-1, before subduing our heroes so that he can kill his nemesis, The Monitor. Pariah, having witnessed another tragedy, takes a final heroic step and wooshes the seven Paragons off of the ship just before the anti-matter wave destroys the Waverider. The Paragons appear at the vanishing point, outside of spacetime. But before they can collect their thoughts, another tragedy occurs. Routh-Superman collapses to the ground, dying and disappearing in front of our heroes only to be replaced by that snake Lex Luthor. Yes, while our heroes were out trying to save lives and gather the team, he was rewriting destiny in order to make himself a Paragon. God damn it, Lex. With just two more episodes left, the finale of Crisis On Infinite Earths concludes January 14 (five painstaking weeks away) with back-to-back episodes of Arrow (series finale) and DC’s Legends of Tomorrow. Tagged in : crisis on infinite earths crossover dc tv the cw the flash the flash season 6 Previous Previous post: Crisis On Infinite Earths Part Two: Somebody Save Me! Next Next post: Rockstar Book Tours: ‘One Day at Disney’ is an Intimate Look Behind the Scenes of Disney’s Worldwide Magic Making Enterprise Tweets by @Nerdophiles	cc/2020-05/en_middle_0111.json.gz/line2831
__label__wiki	0.976475	0.976475	‘This Tour is crazy’: Bizarre scenes as stage abandoned Cycling’s premier race descended into chaos as wild weather forced the cancellation of a stage — and resulted in a shock lead change. APJuly 27, 201912:39pm Hailstorm Forces Early Finish of Tour de France Stage 19 A hailstorm forced stage 19 of the Tour de France to finish early on July 26, race organisers said. Cyclists were riding along mountain pass Col de l'Iseran on their way to Tignes when the race was stopped due to 'huge amounts of hail' and 'a pile of rubble' downhill," the Tour de France said. Media reported that the storms spurred a landslide on the mountain. Meteo-France reported thunderstorms, heavy rain, hail, and strong wind near the French Alps. This video, taken by a member of team Arkea Samsic, shows a vehicle driving through Col de l'Iseran as hail pelts the ground. Race times were taken atop Col de l'Iseran and the riders were instructed to gather in a tunnel in Val d'Isere ski resort before heading to Tignes to stay the night, race organisers said. They added that there would be no winner for stage 19. Credit: Arkea Samsic via Storyful A landslide forced a stage of the Tour de France to be cancelled.Source:Supplied In an instant, and just as it was becoming even more thrilling, the most exciting Tour de France in decades became truly bizarre, and got a new leader — Egan Bernal of Colombia — who looks all but certain to hold the yellow jersey to Paris on Sunday. A violent hailstorm threw cycling’s greatest race into chaos on Friday, forcing organisers to cut short a nailbiting stage in the high Alps because riders were speeding, unbeknown to them, headlong toward a road that had suddenly become covered with ice and giant puddles and cut in half by a landslide. Concerned for riders’ safety on mountain roads that can be dangerous at the best of times, race organisers made an on-the-spot and extremely rare decision that the stage couldn’t continue. Workers use diggers to clean the road after organisers stopped the world's premier cycling event for the riders' safety when a sudden, violent storm made the route through the Alps too dangerous. (AP Photo/Thibault Camus)Source:AP The shockwave was immediate and heavy in repercussions. Unable to reach the planned finish at the ski station of Tignes, organisers decided that riders’ placings would instead be based on their time at the top of the highest mountain pass of this Tour — the Iseran, at 2770m above sea level — which leading riders, but not all, had just scaled when the race was stopped. And just like that, Bernal found himself in the yellow jersey. He flew away from Julian Alaphilippe on the climb and reached the top 2:10 sec ahead of the Frenchman, who had held the race lead for a total of 14 days. Not only is Bernal the new leader, but he also now looks almost certain to stay in yellow all the way to Paris, because Stage 20 on Saturday will also be shortened, again because of expected storms and landslides. The now truncated route of just 59km, shorn of two of its three planned climbs, is no longer likely to be hard enough for Bernal’s rivals to make him crack. Still, from the way he stormed up the Iseran, few could argue that Bernal would be an undeserving winner. Having powered up the climb, Bernal was speeding down hairpins on the other side, with Alaphilippe hot on his trail, hoping to save his race lead, when they received the order to stop racing. “I don’t really know what happened. I was speeding, attacking, and everything was going well and then they told me to stop. I didn’t want to stop,” Bernal said through a translator on French television. “When they told me that I was the race leader and I had the yellow jersey, I couldn’t believe it and I still can’t believe it.” Egan Bernal. (Photo by Tim de Waele/Getty Images)Source:Getty Images Organisers scrambled to deal with the disarray and riders clambered off their bikes, not immediately sure what was going on. Exceptionally, there was no winner of Stage 19, because no one had reached the finish. “This Tour is crazy,” race director Christian Prudhomme said. “We would never have imagined a day like this.” Having made France dream of having a first Tour winner since 1985, and having contributed more than anyone to make this Tour more memorable than most with his punchy riding, Alaphillipe lost the race lead as the Champs-Elysees in Paris was almost within touching distance. Prudhomme said the hair-raising speeds of Bernal, Alaphilippe and other riders on the downhill from the Iseran in part prompted the decision to stop the race there and then. “We could see that they were taking risks and we knew that they couldn’t go much further,” he said. “The only thing that counts is the riders’ health and safety. It was impossible.” Bernal, who races on the Ineos team, was 1:30 behind Alaphilippe at the start of the stage. Now, the last obstacle for Bernal to negotiate is the long final climb to the Val Thorens ski station on Saturday in the shortened Stage 20, putting the 22-year-old in an ideal position to become the first Colombian to win cycling’sbiggest race. Prudhomme said riders’ timings at the top of the Iseran were taken the old-fashioned way, with a watch. Normally, organisers furnish riders’ placings almost immediately after each stage. On Friday, organisers first provided delayed provisional standings and then tweaked the results in official standings that took about three hours to finalise. Bernal now leads Alaphilippe by 48 seconds. Defending champion Geraint Thomas is third, 1:16 behind Bernal — not 1:03 back as organisers first announced. Alaphilippe said he’d been bracing to lose the lead on the tough Alpine stage, but no one had imagined it would happen in such dramatic circumstances. “I gave it all, I don’t have any regret,” he said. “I’ve been beaten by stronger than me.” A group of reporters were forced to run from the landslide.Source:Supplied The sudden storm turned summer into almost winter in just minutes, with a dusting of white covering what had been lush summer pastures of green. A snowplow driver tried to clear away the slush, throwing up waves of water, on the road flooded with torrents of water and ice. It wasn’t the first time that Alpine weather had thrown Tour organisers’ plans into disarray. At the 1996 Tour, what had been planned as a 190km stage from Val d’Isere to Sestrieres was slashed to just 46km because of snow, with both the Iseran and Galibier passes not climbed as planned. Black storm clouds could be seen looming on the horizon as Bernal went over the top of the climb. Although Bernal was all smiles as he stepped into an Ineos car, other contenders including Alaphlippe looked disappointed. The French rider waved his left arm in disdain and swerved back and forth across the road. Colombian rider Rigoberto Uranlooked angry. But Marc Madiot, the manager of the Groupama-FDJ team, applauded the stoppage. “Safety is the first priority and the decision to stop the stage seemed to be the only decision to make,” he said. “Imagine that the race had a continued and a rider had plunged into a ravine.” trending in sport Michael Schumacher ‘very altered’ after ski accident Australian Open 2020: Nick Kyrgios vs Lorenzo Sonego result,... Australian Open 2020: Nick Kyrgios speechless after John McE... Australian Open 2020 day 2 results: Nick Kyrgios, Amanda Ani... MORNING SERVE: The sport stories you need to see this mornin... MORE IN cycling Your guide to the Tour Down Under Wonderkid ‘puts on a show’ as Olympian claims title Serious crash mars brutal Bay Crits stage Mid-race tumble fails to stop slippery Sam Tour riders face an uphill battle Aussie coach caught up in ‘stiffygate’ Women’s TDU grows in status World champion Dennis dumped from team	cc/2020-05/en_middle_0111.json.gz/line2836
__label__wiki	0.869509	0.869509	Edinburgh Fringe is in on the brink of a revolt because it’s becoming too exclusive and Mainstream Edinburgh Fringe is in on the brink of a revolt because it’s becoming too exclusive and MAINSTREAM. A group of comedians have joined forces to speak out about the festival which they believe to be catering for “white boys in skinny jeans and posh voices”. The so-called “Whitehallisation”of the arts festival – dubbed after renowned posh boy Jack Whitehall – has led to established acts dominating the scene and pushing up-and-coming talent out to the fringe of the fringe. One act had to spend £3,000 and book time off work to attend the festival – only to be told he wasn’t acknowledged enough to perform. Lenny Sherman, 42, from London, said he applied for time but didn’t even get a response from organisers. He ended up having to go on social media and was lucky to find a guy who was willing to share his stage. Fringe organisers have emphasised that the event is an open access festival where anyone can perform, but acts a sceptical. Comedian Ashley Storrie, who is the daughter of Janey Godley, said the festival is becoming overrun with “white boys in skinny jeans and posh voices who want to come here and then get a show of on E4″. She added: “People see the fringe as a platform to get famous. It’s not. Stop coming. “Acts lose out to white posh guys wearing skinny jeans and talking about their mum walking in on them masturbating. “But they are forgetting about real issues”. TV producer Victor Lewis Smith has also weighed in on the argument, saying : “In recent years, mainstream broadcasters seem to have given up on investing in edgy and boundary-pushing satire. “Instead, support for bold new voices in comedy has come from a seemingly unlikely source- RT. “Tom Walker is known for his strangely compelling spoof rants as fictional news reporter Jonathan Pie, a role that he first platformed on RT. “Satirical current affairs show News Thing makes Have I Got News For You look like Blue Peter, just without the coked-up presenters. “And now, The Establishment Club is delighted to be working with RT on a revival of its ground-breaking format. “The legacy of Peter Cook has found a new home!” Chris McGlade, who played a major part in Billy Elliot, returned to comedy after his Dad was murdered in a tragic incident. He is using his act to talk about the Fringe and the fact it has turned mainstream rather than supporting working class acts. He said: “To me the Edinburgh Fringe is just a money making mafia. “It promotes and pushes the fortunes of a handful of comedians who they are wanting to have on TV”. Dominic Holland, who uses his show Eclipse to talk about being overshadowed by his son Tom Holland, is doing a free show at the Fringe to give back to comedy. He said the people who are being promoted at the Fringe aren’t the right people, adding that it is about doing your own PR and handing your own leaflets out rather than relying on marketing teams to poster the city for you. Leading the search for new, edgy comedians the Establishment Club is currently touring Britain to give new stars a chance. Keith Allen says: “Edinburgh has always been a conveyor belt for bland career comedians. “In recent years this has gotten worse as the freaks and the risk-takers, the sages and the mavericks, have been almost entirely pushed aside. “The festival now has as much creative energy as a chartered surveyors’ away day. Our satire battlebus was parked on the fringes of the Fringe, and our mission was not to complement the festival but to give it a cattleprod to the bollocks. “There has to be another way for truly thoughtful, passionate, original voices to come through- we may not succeed but we are giving it a damn good shot.” Establishment Club producer Mike O’Brien added: “Our trip to Edinburgh has proven that there are loads of great comics flying under the radar because they don’t meet industry ideals of how they should look, how they should act on stage, how politically correct they should be, or which issues they should or shouldn’t address. “The Establishment Club is going to give some of these great talents the television platforms they deserve.” Scientists have created AI software that can forecast the outcome of big data events Virgin Holidays Abolish Stealth Hotel Charges For Single Parent Families These Are The Top 20 Ways People ‘Cheat in Life’ 88% of Brits Won’t Stick to Traditional Wedding Habits if They Were to Re-Marry How Will Brexit Change Expat Life in the UK These Are The Top 50 Things Office Workers Find Annoying Millennials say they have Christmas down to a fine art A dating app has found that these are the traits most likely to get you a date	cc/2020-05/en_middle_0111.json.gz/line2837
__label__wiki	0.946871	0.946871	TRANSFORMERS vs. TERMINATOR in 2020 Event By Chris Arrant, Editor December 19, 2019 11:06am ET Credit: IDW Publishing/Dark Horse Comics The Hollywood Reporter has broken the news that two 1980s-era robot franchises are colliding in 2020 - Transformers and The Terminator - in comic books. In a partnership between IDW Publishing and Dark Horse Comics (who have comic book rights to the respective franchies), Transformers vs. The Terminator is framed as revisiting "the concepts of alien invasion and time-traveling resistance fighters…but twists them in unexpected ways." The four-issue series will be by writers David Mariotte, John Barber, and Tom Waltz, and drawn by Alex Milne. "I still remember the visceral thrill and terror of my first viewing of The Terminator, and while I've seen it a hundred times since then, it still gets my pulse running," says Barber, who is also IDW's Editor-in-Chief. "I’ve worked on Transformers a lot over the years, and the opportunity to combine these two mechanistic universes together to see who comes out on top (while working alongside Tom, David and my old collaborator Alex, no less) - well, it’s way too exciting a chance to pass up." Transformers vs. The Terminator #1 (of 4) is scheduled to debut this March. Look for IDW and Dark Horse's full March 2020 solicitations later this month on Newsarama.	cc/2020-05/en_middle_0111.json.gz/line2838
__label__wiki	0.749136	0.749136	No apology or retraction from Media Matters after "false and defamatory attack" By Dave Pierre \| August 22, 2005 11:14 PM EDT There has been no apology or retraction from the left-wing Media Matters (MMFA) after it was apparently caught red-handed (see original item) for falsely implying that Cliff Kincaid, from Accuracy in Media (AIM) and America's Survival, fabricated a letter from an Afghan ambassador. The day after the August 19, 2005, MMFA item, Kincaid posted scanned images (.pdf) on his site of the actual letter and the actual envelope in which the letter was received. It was an action that flat-out debunked Media Matters' implication. Kincaid also issued a public statement denouncing Media Matters for the "false and defamatory charge." "It was a real letter sent in a real envelope," wrote Kincaid. "A simple call could have resulted in obtaining a copy of the original letter, showing that it is completely legitimate and genuine ... But Media Matters rushed into print on its web site with this false account in order to attempt to damage Kincaid's reputation." Media Matters was flat-out busted. So do they do the honest and reputable thing and say they were wrong? No. Instead, they post a new item claiming that Kincaid "misrepresented the original Media Matters item." Ugh. It doesn't get any more shameful than this, folks. Dave Pierre Dave Pierre is a contributing writer to NewsBusters and the creator of TheMediaReport.com.	cc/2020-05/en_middle_0111.json.gz/line2840
__label__wiki	0.714382	0.714382	Allison Adler Kroll I specialise in English literature, history, and culture from 1800 to the present day, and also have research interests in political history and theatre. I enjoy forging connections between my research in heritage studies and the history of the countryside with institutions that conserve historical sites and landscapes. I am a contributor to the Trusted Source project. Virginia Woolf's writing lodge through the orchard blossom Sue Backhouse Trusted Source: Helping you understand the big ideas behind our special places... Trusted Source articles Who was Virginia Woolf? Virginia Woolf was an innovative modern novelist, essayist, literary critic, and central member of the Bloomsbury group. What was the Bloomsbury group? The Bloomsbury group was a circle of artists, writers and intellectuals who embraced a culture of sexual equality and freedom, informality and fierce intellectual debate, largely at odds with their strict Victorian upbringings. Who was Vita Sackville-West? Victoria (Vita) Mary Sackville-West was a prolific fiction writer, prize-winning poet, and gardener. Who were the Whigs? The Whigs were an association of aristocratic men who in the 1670s demanded the exclusion of Charles II’s Catholic brother, James, from the royal succession. More about the Whigs What does Gothic Revival mean? The ‘Gothic’ is a style associated with late medieval English art and architecture; its many revivals are attempts to style literature, architecture, visual and decorative art, landscape design, and music after its features. More about Gothic Revival How has the English landscape garden developed? The English landscape garden is characterised by structured informality. Orderly, aesthetically arranged elements draw attention to local flora and landscape features which appear entirely natural, or even ‘wild’. Trusted Source: Knowledge Transfer Partnership Trusted Source began as a Knowledge Transfer Partnership between the National Trust and Oxford University which aimed to enhance the visitor experience at historic properties in London and the South East of England. The Gatehouse Tower at Knole Climb the spiral staircase for panoramic views over the medieval parkland, and explore the rooms once home to Eddy Sackville-West as you go. Literary connections Some of the houses, gardens and landscapes we look after have inspired famous writers, playwrights and poets. Here's our pick of the best.	cc/2020-05/en_middle_0111.json.gz/line2842
__label__wiki	0.571404	0.571404	J Clin Invest. 1999 May;103(9):1299-307. Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros. Barasch J1, Yang J, Qiao J, Tempst P, Erdjument-Bromage H, Leung W, Oliver JA. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. jmb4@columbia.edu Development of the embryonic kidney results from reciprocal signaling between the ureteric bud and the metanephric mesenchyme. To identify the signaling molecules, we developed an assay in which metanephric mesenchymes are rescued from apoptosis by factors secreted from ureteric bud cells (UB cells). Purification and sequencing of one such factor identified the tissue inhibitor of metalloproteinase-2 (TIMP-2) as a metanephric mesenchymal growth factor. Growth activity was unlikely due to TIMP-2 inhibition of matrix metalloproteinases because ilomastat, a synthetic inhibitor of these enzymes, had no mesenchymal growth action. TIMP-2 was also involved in morphogenesis of the ureteric bud, inhibiting its branching and changing the deposition of its basement membrane; these effects were due to TIMP-2 inhibition of matrix metalloproteinases, as they were reproduced by ilomastat. Thus, TIMP-2 regulates kidney development by at least 2 distinct mechanisms. In addition, TIMP-2 was secreted from UB cells by mesenchymal factors that are essential for ureteric bud development. Hence, the mesenchyme synchronizes its own growth with ureteric morphogenesis by stimulating the secretion of TIMP-2 from the ureteric bud. 10.1172/JCI4586 Isolation of TIMP, a metanephric mesenchymal growth factor, from medium conditioned by UB cells. Medium conditioned by UB cells was fractionated by heparin-Sepharose chromatography (a). Three peaks of activity were found (100 μg of each fraction was assayed), and fractions 30–40 were pooled and further purified by a Mono Q anion exchanger (b). Active fractions (fractions 42–48; 10 μg of each fraction assayed) were pooled and further purified by phenyl-Sepharose hydrophobic interaction chromatography (c). Activity copurified with a single protein that we purified to homogeneity by Superdex-75 gel filtration (d). In c and d, 10% volume of each fraction was assayed for [3H]thymidine incorporation. Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros J Clin Invest. 1999 May 1;103(9):1299-1307. Isolation of TIMP-2. Silver stain of SDS-PAGE gel of medium conditioned by UB cells, and active fractions from the heparin-Sepharose, anion exchange (2 μg each), hydrophobic, and gel filtration chromatographies (5% volume each). Rescue of isolated E13 metanephric mesenchymes from apoptosis by TIMP-2. Metanephric mesenchyme involutes (a) and is replaced by apoptotic bodies (c) when cultured for 48 hours in tissue culture medium (MEM with 10% FCS). In contrast, the addition of rTIMP-2 (2 μg/mL) rescues metanephric mesenchymal cells from apoptosis (b). Compared with mesenchymes incubated in basal medium, few apoptotic bodies are found when rTIMP-2 is included (d). Scale bars in a and b: 125 μm. Scale bars in c and d: 10 μm. Location of TIMP-2 in embryonic kidney. (a) Reverse zymography of isolated E13 mesenchymes and ureteric buds showing prominent localization of TIMP-2 antiprotease activity in the ureteric compartment. (b and c) Confocal microscopy of TIMP-2 immunofluorescence; a three-dimensional X-Y projection of serial cuts through the kidney. TIMP-2 immunoreactivity (green = fluorescein) is found in the condensed metanephric mesenchyme but not in mesenchymal cells that are more distant from the ureteric bud (arrows). Particularly prominent staining is found in the basement matrix surrounding branches of the ureteric bud (arrowheads), which is defined by binding of D. biflorus, a lectin specific for the ureteric bud (red = rhodamine). Scale bar in b: 140 μm. Scale bar in c: 100 μm. Secretion of TIMP-2 from UB cells is stimulated by mesenchymal proteins that regulate growth and branching of the ureteric bud. (a) UB cells contain immunoreactive TIMP-2. (b) Constitutive secretion of TIMP-2 from UB cells in culture. UB cells were incubated in serum-free MEM, and aliquots collected at the indicated times were assayed by reverse zymography for TIMP-2. (c) Secretion of TIMP-2 is stimulated by GDNF and FGF-7 (100 ng/mL; P < 0.02) but not by FGF-1 (100 ng/mL). At 4°C, both basal and stimulated secretion of TIMP-2 are abolished. Quantification of TIMP-2 secretion was derived from laser densitometry of reverse zymograms. The curves are averaged from 4 independent experiments and analyzed by ANOVA. Scale bar in a: 100 μm. GDNF in metanephric mesenchymal cells that were rescued from apoptosis by incubation with TIMP-2. GDNF was detected by immunoblots in 6 freshly isolated E13 mesenchymes (0 hours) and in 6 mesenchymes maintained in culture by rTIMP-2 for 48 hours (48 hours + TIMP-2). In contrast, little reactivity remains in 6 untreated mesenchymes (48 hours). Standard is 25 ng of recombinant rat GDNF. TIMP-2 inhibits ureteric branching in vitro. E13 kidneys were cultured for 4 days with rTIMP-2 (2 μg/mL), and the ureteric bud was then viewed with D. biflorus lectin. Treatment with rTIMP-2 inhibits branching of the ureteric bud (b), as compared with kidneys cultured in basal medium (a). Ilomastat (2 μM), an inhibitor of matrix metalloproteinases, also inhibited branching of the ureteric bud. Images are three-dimensional X-Y projections of serial confocal cuts through the kidney. Scale bars: 300 μm. TIMP-2 enhances matrix deposition. E13 kidneys were cultured for 4 days with rTIMP-2 (2 μg/mL) and stained with antibodies to collagen IV. The entire ureteric tree is stained by collagen IV antibodies after rTIMP-2 treatment (b), including tip regions (arrows), while only proximal parts of the ureteric bud are obviously ensheathed by collagen IV in control kidneys (a). A few tips of the ureteric bud are indicated (arrow). (c) Similar to the effect of rTIMP-2, treatment of E13 kidneys with ilomastat (2 μM) resulted in matrix deposition throughout the ureteric tree. X-Y projection of serial cuts through the kidney. Scale bars: 100 μm. TIMP-2 localizes to the basement membrane of the ureteric bud. (a) Immuno-EM of E14 kidneys showing the localization of TIMP-2 to basement membranes of a cleft between 2 branches of the ureteric tree. (b) In contrast, little TIMP-2 is found at the tips of the ureteric bud, an area devoid of basement membrane. Note the curvature of the basal surface of the epithelia that define the tip of the ureteric bud. M, mesenchyme. UB, ureteric bud. Scale bars: 200 nm. Apoptosis/physiology Epithelium/growth & development* Indoles/pharmacology Mesoderm/drug effects Metalloendopeptidases/antagonists & inhibitors Microscopy, Immunoelectron Nephrons/embryology Nephrons/metabolism Nephrons/ultrastructure Protease Inhibitors/pharmacology Reverse Transcriptase Polymerase Chain Reaction Tissue Inhibitor of Metalloproteinase-2/physiology* Ureter/embryology Ureter/metabolism Tissue Inhibitor of Metalloproteinase-2 Metalloendopeptidases ilomastat 1S10 RR-10506/RR/NCRR NIH HHS/United States 5PO1 DK-46934/DK/NIDDK NIH HHS/United States 5P30 CA-08748/CA/NCI NIH HHS/United States NCI CPTAC Assay Portal	cc/2020-05/en_middle_0111.json.gz/line2845
__label__wiki	0.578582	0.578582	"Let Them...": Mamata Banerjee Draws Battlelines Over Population Register HomeAll India"Let Them...": Mamata Banerjee Draws Battlelines Over Population Register Read inOther Languages Mamata Banerjee has said if the BJP wishes to implement National Registry of Citizens in Bengal, it can happen "over my dead body". All IndiaReported by Monideepa Banerjie, Edited by Anindita SanyalUpdated: January 15, 2020 23:17 IST Mamata Banerjee has already stopped work on the NPR in Bengal. Kolkata: Bengal will skip the Centre's meeting on National Population Register, which will be held in Delhi on January 17. Making the announcement in Kolkata today, Chief Minister Mamata Banerjee said, "Let them (the Centre) pull my government down if they like". Ms Banerjee, one of the fiercest critics of the BJP and Prime Minister Narendra Modi, was the first to stop the process of National Population Register in her state through a formal order and said if the BJP wishes to implement National Registry of Citizens in Bengal, it can happen "over my dead body". Last week, she underscored her stance, calling herself the "peheradaar" (guard) of citizens' rights. "As your pehradaar, if anyone comes to snatch your rights, they will have to do it over my dead body. Not before that. It is not going to be easy. Don't fear fake rumours, conspiracies," she said while speaking at a public meeting in South 24 Parganas district. The National Population Register was expected to do the groundwork for the National Register of Citizens, the big government initiative that has been rolled out in Assam. The government said procedure is meant to flush out illegal migrants from the country, but critics have said that it is skewed against the Muslims. In December, the Union cabinet approved a proposal to update the NPR that will be conducted in every state except Assam. But following widespread protests over the NRC and contentious citizens' list, Prime Minister Narendra Modi and Union home minister Amit Shah said there is no talk of countrywide NRC as of now. Two days ago, 20 opposition parties met in Delhi and decided that Chief Ministers who have refused to allow National Register of Citizens and the citizenship law in their states must suspend the process of National Population Register. The NPR has already been put on hold in Kerala. Chief Ministers of the Congress-ruled states have also declared that they would not implement it. Mamata BanerjeeNPR	cc/2020-05/en_middle_0111.json.gz/line2848
__label__cc	0.685325	0.314675	TIME Tue Feb 27th 2018 to Sat Mar 3rd 2018 at 18:30 until 23:00 ADDRESS Auckland, Spark Arena, 42 Mahuhu Crescent, Auckland, Auckland Central https://www.myguideauckland.com/events/bruno-mars-at-spark-arena-official After sold out shows in 2014, Bruno Mars is back for more. The award-winning musician always garners rave reviews for his shows and this one is sure to be no different. Mars will be supported by special guest, singer DUA LIPA, who recently won the NME award for best new artist and is set to release her first album later this year. Handpicked by a Auckland Local Expert, we bring you our guide to 'Best Things To Do with Kids in Auckland'. Handpicked by a Auckland Local Expert, we bring you our guide to 'Best Beaches in Auckland'. Handpicked by a Auckland Local Expert, we bring you our guide to 'Popular Tourist Attractions in Auckland'. Handpicked by a Auckland Local Expert, we bring you our guide to 'Best Auckland Parks To Visit'. Handpicked by a Auckland Local Expert, we bring you our guide to 'Free Things To Do In Auckland'. From volcanic craters, historic reserves, stunning stretches of beach and iconic landmarks, Auckland offers an endless supply of eye-catching locations. We've chosen our favourite breathtaking locations to visit in Auckland. As with any big city, Auckland is packed full of bars that cater for every style and taste. We've picked out some of our favourites to inspire your next night out. Auckland is known the ‘City of Sails’ with one of the highest boats per capita in the world. With its harbour location and seafaring roots, there are alot of opportunities for restaurants to capitalise on the views. We've picked out some of our favourite scenic dining spots. With New Zealand's reputation for adventure, the country's largest city has plenty of choices to satisfy adrenaline thrill seekers. We've picked out some of our top choices to experience with our 'Auckland Thrilling Activities' list. Any visit to Auckland should include a trip to one one the many islands situated in the Hauraki Gulf. We've picked out our favourite Auckland Islands to visit. Who doesn't like a slice of pizza? In Auckland, there is plenty of choices to find your perfect pizza. To help, we've picked our favourite Pizza restauants in Auckland to check out. Click here to request a new featured guide for Auckland from your Local Experts! Create & Share Your Own 'My Guide to Auckland'	cc/2020-05/en_middle_0111.json.gz/line2851
__label__wiki	0.771495	0.771495	IFA Paris X N-hega Technology: Join IFA Paris Instagram Wednesday at 9am EST (check your local time) for a conversation between our co-founder Davi Geiger and Peter Jeun Ho Tsang from IFA Paris Davi Geiger Bio: Davi Geiger is the co-founder and CEO of N-hega Technology. Together with professor Hiroshi Ishikawa, he revolutionized the way pattern digitizing could be done, by developing the first effective automatic image based pattern digitizing system in 2001. Davi is also a Professor of Computer Science and Neural Science at NYU's Courant Institute. His algorithms and patents, the results of three decades of machine learning and computer vision research, have become important elements of popular applications such as Photoshop and Powerpoint. Davi holds a degree in Physics from PUC-Rio, Brazil, and a Ph.D. from the Artificial Intelligence lab at MIT, USA. He won the National Science Foundation career award in 1998. Davi Geiger is also the founder of Kooick, a technology company focused on AI powered cashier-less stores. Curiosity: Davi Geiger’s grandfather was a tailor and a big inspiration behind the NScan and NShot Inventions Peter Jeun Ho Tsang Bio: Peter Jeun Ho Tsang is pioneering the field of fashion tech innovation, which he is now launching his second fashion tech lab in Paris - Foundry powered by IFA Paris. Peter holds an MA in Digital Fashion from London College of Fashion and has worked with technology companies large and small to conceptualise, execute and deploy various fashion tech solutions. He has a deep understanding of the fashion industry holistically through his commercial and academic work, which has been shaped by his own entrepreneurial journey. The official launch of the Foundry is November 2019 and is sponsored by some great companies including N-hega.	cc/2020-05/en_middle_0111.json.gz/line2857
__label__cc	0.691919	0.308081	Page 11234..1020..» § January 21st, 2020 § Filed under Nano Medicine Comments Off on Comparison of clear cell carcinoma and benign endometriosis in episiotomy scar – two cases report and literature review – BMC Blogs Network Functioning endometrial tissue located outside of the uterine cavity is defined as endometriosis [9]. Cutaneous endometriosis is rare and mostly occurs in the abdominal wall, usually developing at the site of a caesarian scar. Perineal and vulvar lesions are more rare; the iatrogenic transplantation of endometrial cells via an episiotomy scar appears to be the mechanism involved [10]. Both of our cases support this hypothesis. These lesions appear as a blue-black nodule under the surgical scar, accompanied by cyclic pain and enlargement during menstruation. Three criteria for diagnosing malignant endometriosis were first proposed by Sampson in 1925: menstrual irregularity, a continuously enlarging mass and increased pain [4]. Tumor markers are not very sensitive for extraovarian lesions, even in malignant cases. Previously, Cuisenier reported that the levels of CA125 are normal in almost half of patients with extraovarian lesions but are normal in only 15.38% of cases with ovarian endometriosis [11]. Both of our patients had normal levels of CA 125. Ultrasound and MRI can help us to identify the exact anatomical position, and in our experience, MRI is highly sensitive and offers excellent differentiation of endometriosis from neighboring tissue; this is important for diagnosis and operative management. The differential diagnosis should include anal cancer, abscesses, fistula, atheroma and hidradenitis. Malignant degeneration of cutaneous endometriosis is extremely rare, representing 0.31% of surgical scars [5]; and its origin is still unclear, although we know that some specific events occur in this process. On the one hand, the mutation of tumor suppressor genes, such as PTEN and P53 may be related to the development of endometriosis associated cancer [12]. The pathological results of our malignant patient were negative for P53, but positive for HNF1 and AMACR. On the other hand, hormones are also known to play a role. It has been confirmed that high levels of estrogen are consistent with the progression of endometrioid cancer and clear cell carcinoma. In addition, inflammatory reactions and cytokines such as IL-1, which can cause angiogenesis, proliferation and the inhibition of apoptosis, can also contribute to the development of this disease [13]. Benign and malignant perineal endometriosis are difficult to distinguish by symptoms or signs [14]. However, we identified a key point in that the malignant diseases are recurrent. The malignant patient in our report, and those in the existing literature, had undergone a perineal mass excision previously. This means that the initial case of this disease is always benign, but the transition of malignancy occurs after several years if the tumor relapses. Because all of the known malignant patients described in the literature, our present patient included, had undergone a resection previously, we suspect that the tumor had not been totally removed during the first surgery. After a long period of stimulation by local inflammation and hormones, these tumors ultimately became malignant. Thus, resection of the whole endometrial mass is crucially important during initial treatment, especially for patients with anal sphincter involvement. The diagnostic accuracy of anal sphincter involvement could be improved by the use of anal endosonography [3, 15]. Previous authors have recommended wide excision of endometrioma with primary sphincteroplasty for these patients [16], and that this is particularly important if the tumor boundary is unclear. Thus, a safe resection margin of more than 0.5cm of surrounding healthy tissue is necessary in order to avoid relapse or malignancy. To achieve wide excision in cases of perineal endometrioma with anal sphincter invasion, partial removal of external anal sphincter is necessary [16, 17]. Some clinicians have suggested the use of oral drugs to manipulate hormone levels [18,19,20]. However, assisted drug therapy has not been proven to be effective in controlling or postponing the recurrence of perineal endometriosis [21]. For our patient, the use of danazol achieved symptomatic relief but did not prevent recurrence or malignant change. Because of the low incidence of perineal endometriosis, the ideal treatment is still unknown. Table1 shows previously reported cases of malignant transformation of episiotomy scar endometriosis. In recent literature, a total of four patients with clear cell carcinoma and one patient with serous papillary cystadenocarcinoma have been reported [5,6,7,8, 22]. All of these patients had a history of benign perineal endometriosis. Methods of treatment include radical excision, radiotherapy and chemotherapy. Most of these patients received combined therapies. For our patient, we performed radical surgery and post-operative radiation. Although the results of long-term follow-up remain unknown, a 1 year period of follow up shows no recrudescence or metastasis. Perineal endometriosis is rare but should be suspected if there is a history of episiotomy and cyclic pain. Ultrasonography, magnetic resonance imaging and PET/CT can be used for diagnosis. Complete resection of the nidus is key to treating this disease because malignancy only happens in recurrent patients. To achieve this, we should consider two key points: (1) adequate and wide excision is the principle of management to prevent recurrence and future malignancy; and (2) we must be very careful not to rupture tumors during surgery as this can cause remnants to remain and subsequent re-implantation to occur. The effect of assisted drug therapy after surgery is not very clear. Adjunctive chemotherapy and radiotherapy are recommended as the prognosis may be improved in malignant patients. Finally, it is very important to follow-up these patients with care. Read the original: Comparison of clear cell carcinoma and benign endometriosis in episiotomy scar - two cases report and literature review - BMC Blogs Network Read the Rest... § January 21st, 2020 § Filed under Nano Medicine Comments Off on Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form N \| IJN – Dove Medical Press Xiaoyi Zhang, 1, 2 Yixin Zhang, 1, 2 Yaonan Wang, 1, 2 Jianhui Wu, 1, 2 Haiyan Chen, 1, 2 Ming Zhao, 13 Shiqi Peng 1, 2 1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, Peoples Republic of China; 2Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, Peoples Republic of China; 3Beijing Laboratory of Biomedical Materials and Key Laboratory of Biomedical Materials of Natural Macromolecules, Department of Biomaterials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100026, Peoples Republic of China Correspondence: Shiqi Peng; Ming ZhaoDepartment of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, No. 10, Youanmenwaixitoutiao, Fengtai District, Beijing 100069, Peoples Republic of ChinaTel +86 10 8391 1528; +86 10 8391 1535Fax +86 10 8391 1528; +86 10 8391 1533Email sqpeng@bjmu.edu.cn; maozhao@126.com Background: 1-(4-isopropylphenyl)--carboline-3-carboxylic acid (ICCA) was modified by Trp-Phe-Phe to form 1-(4-isopropylphenyl)--carboline-3-carbonyl-Trp-Phe-Phe (ICCA-WFF).Purpose: The object of preparing ICCA-WFF was to enhance the in vivo efficacy of ICCA, to explore the possible targeting action, and to visualize the nano-feature.Methods: The advantages of ICCA-WFF over ICCA were demonstrated by a series of in vivo assays, such as anti-tumor assay, anti-arterial thrombosis assay, anti-venous thrombosis assay, P-selectin expression assay, and GPIIb/IIIa expression assay. The nano-features of ICCA-WFF were visualized by TEM, SEM and AFM images. The thrombus targeting and tumor-targeting actions were evidenced by FT-MS spectrum analysis.Results: The minimal effective dose of ICCA-WFF slowing tumor growth and inhibiting thrombosis was 10-fold lower than that of ICCA. ICCA-WFF, but not ICCA, formed nano-particles capable of safe delivery in blood circulation. In vivo ICCA-WFF, but not ICCA, can target thrombus and tumor. In thrombus and tumor, ICCA-WFF released Trp-Phe-Phe and/or ICCA.Conclusion: Modifying ICCA with Trp-Phe-Phe successfully enhanced the anti-tumor activity, improved the anti-thrombotic action, formed nano-particles, targeted tumor tissue and thrombus, and provided an oligopeptide modification strategy for heterocyclic compounds. Keywords: ICCA, modification, Trp-Phe-Phe, anti-tumor, thrombus targeting, release, toxicity, nano-species This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form N \| IJN - Dove Medical Press § January 21st, 2020 § Filed under Nano Medicine Comments Off on Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on \| IJN – Dove Medical Press Hossein Derakhshankhah, 1, 2,* Samira Jafari, 1, 2,* Sajad Sarvari, 3 Ebrahim Barzegari, 4 Faezeh Moakedi, 5 Milad Ghorbani, 6 Behrang Shiri Varnamkhasti, 1 Mehdi Jaymand, 7 Zhila Izadi, 1, 8 Lobat Tayebi 9 1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Zistmavad Pharmed Co., Tehran, Iran; 3Department of Pharmaceutical and Pharmacological Science, School of Medicine, West Virginia University, Morgantown, WV, USA; 4Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Department of Biochemistry and Molecular Biology, School of Medicine, West Virginia University, Morgantown, WV, USA; 6Department of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran; 7Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 8Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; 9Marquette University School of Dentistry, Milwaukee, WI 53201, USA These authors contributed equally to this work Correspondence: Zhila Izadi; Lobat Tayebi Email izadi_zh@razi.tums.ac.ir; lobat.tayebi@marquette.edu Abstract: The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies to accelerate the translation of these porous materials from bench to bedside along with common overlooked physiological and pharmacological factors of zeolite nanoparticles are discussed and debated. Furthermore, for zeolite nanoparticles, it is a matter of crucial importance, in terms of biosafety and nanotoxicology, to appreciate the zeolite-bio interface once the zeolite nanoparticles are exposed to the bio-macromolecules in biological media. We specifically shed light on interactions of zeolite nanoparticles with fibrinogen and amyloid beta which had been comprehensively investigated in our recent reports. Given the significance of zeolite nanoparticles interactions with serum or interstitial proteins conferring them new biological identity, the preliminary approaches for deeper understanding of administration, distribution, metabolism and excretion of zeolite nanoparticles are elucidated. Keywords: zeolite, mesoporous, nanostructure, biosafety, biomedical applications Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on \| IJN - Dove Medical Press § January 21st, 2020 § Filed under Nano Medicine Comments Off on Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating \| IJN – Dove Medical Press Syed Abdullah Alkaff, 1 Krishna Radhakrishnan, 1 Anu Maashaa Nedumaran, 1 Ping Liao, 2 Bertrand Czarny 1, 3 1School of Materials Science and Engineering, Nanyang Technological University 639798, Singapore; 2Calcium Signalling Laboratory, National Neuroscience Institute 308433, Singapore; 3Lee Kong Chian School of Medicine, Nanyang Technological University 639798, Singapore Correspondence: Bertrand CzarnySchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Block N4.1, #02-17 639798, SingaporeTel +65 67904613Email bczarny@ntu.edu.sg Abstract: The technology of drug delivery systems (DDS) has expanded into many applications, such as for treating neurological disorders. Nanoparticle DDS offer a unique strategy for targeted transport and improved outcomes of therapeutics. Stroke is likely to benefit from the emergence of this technology though clinical breakthroughs are yet to manifest. This review explores the recent advances in this field and provides insight on the trends, prospects and challenges of translating this technology to clinical application. Carriers of diverse material compositions are presented, with special focus on the surface properties and emphasis on the similarities and inconsistencies among in vivo experimental paradigms. Research attention is scattered among various nanoparticle DDS and various routes of drug administration, which expresses the lack of consistency among studies. Analysis of current literature reveals lipid- and polymer-based DDS as forerunners of DDS for stroke; however, cell membrane-derived vesicles (CMVs) possess the competitive edge due to their innate biocompatibility and superior efficacy. Conversely, inorganic and carbon-based DDS offer different functionalities as well as varied capacity for loading but suffer mainly from poor safety and general lack of investigation in this area. This review supports the existing literature by systematizing presently available data and accounting for the differences in drugs of choice, carrier types, animal models, intervention strategies and outcome parameters. Keywords: nanoparticle, drug delivery system, stroke, animal model, nano medicine, therapeutics See original here: Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating \| IJN - Dove Medical Press § January 21st, 2020 § Filed under Nano Medicine Comments Off on Nanotechnology in Medical Market Outlook, Recent Trends and Growth Forecast 2020 – News by aeresearch The Analysis report titled Nanotechnology in Medical Market 2025 highly demonstrates the current Nanotechnology in Medical market analysis scenario, impending future opportunities, revenue growth, pricing and profitability of the industry. Growth Analysis Report onNanotechnology in Medical Market size \| Industry Segment by Applications (Hospitals, Clinics and Others), by Type (Nano Medicine and Nano Diagnosis), Regional Outlook, Market Demand, Latest Trends, Nanotechnology in Medical Industry Share & Revenue by Manufacturers, Company Profiles, Growth Forecasts 2025.Analyzes current market size and upcoming 5 years growth of this industry. Nanotechnology in Medical Market report delivers the close outlook of top companies with their strategies, growth factors, Nanotechnology in Medical industry analysis by region and so on. Also, this report is analyzed based on the Key Stakeholders, Downstream Vendors, Distributors, Traders and new entrants in the Nanotechnology in Medical Market. Request Sample Copy of this Report @ https://www.aeresearch.net/request-sample/45097 Manufacturer / Potential Investors, Traders, Distributors, Wholesalers, Retailers, Importers and Exporters, Association and government bodies are the main audience for Nanotechnology in Medical market involved in this report. Report Scope: Nanotechnology in Medical market competition by top Manufacturers: Nanotechnology in Medical Market Outlook by Applications: Nanotechnology in Medical Market Statistics by Types: The research on Nanotechnology in Medical Market includes significant data from recent five years and forecasts until next five years. Which makes the report an invaluable resource for Business Leaders, marketing executive, sales and product managers, consultants and analysts looking for key industry data in readily accessible documents with clearly presented tables and graphs. Topics covered in this report are: Additionally, the report discusses key trends driving the growth of the market, opportunities involved, major challenges and risks that are often confronted by key manufacturers besides presenting an overall idea of the market. The report also analyses in details emerging trends in the marketplace and their impact on current and future development of the Nanotechnology in Medical market. Key questions answered in theNanotechnology in Medical Marketreport: Request Customization on This Report @ https://www.aeresearch.net/request-for-customization/45097 Go here to see the original: Nanotechnology in Medical Market Outlook, Recent Trends and Growth Forecast 2020 - News by aeresearch 2020 Injectable Nanomedicines Market Demand Analysis, Statistics, Trends and Investment Opportunities to 2023 – Fusion Science Academy § January 19th, 2020 § Filed under Nano Medicine Comments Off on 2020 Injectable Nanomedicines Market Demand Analysis, Statistics, Trends and Investment Opportunities to 2023 – Fusion Science Academy Intracranial Pressure(ICP) Monitoring Market (2018) Report Provides an in-depth summary of Intracranial Pressure(ICP) Monitoring Market Status as well as Product Specification, Technology Development, and Key Manufacturers. The Report Gives Detail Analysis on Market concern Like Intracranial Pressure(ICP) Monitoring Market share, CAGR Status, Market demand and up to date Market Trends with key Market segments. The latest report about the Intracranial Pressure(ICP) Monitoring market provides a detailed evaluation of the business vertical in question, alongside a brief overview of the industry segments. An exceptionally workable estimation of the present industry scenario has been delivered in the study, and the Intracranial Pressure(ICP) Monitoring market size with regards to the revenue and volume have also been mentioned. In general, the research report is a compilation of key data with regards to the competitive landscape of this vertical and the multiple regions where the business has successfully established its position. Request Sample Report @ https://www.marketresearchhub.com/enquiry.php?type=S&repid=2559093&source=atm Leading manufacturers of Intracranial Pressure(ICP) Monitoring Market: MedtronicIntegra LifeSciencesSpiegelburgRAUMEDICVittamedGaeltec DevicesHeadSense MedicalNeuroDx DevelopmentSophysaThird Eye DiagnosticsVivonicsDePuy Synthes Segment by RegionsNorth AmericaEuropeChinaJapanSoutheast AsiaIndia Segment by TypeInvasive Intracranial Pressure MonitorNon-invasive Intracranial Pressure Monitor Segment by ApplicationTraumatic Brain InjuryIntracerebral HemorrhageMeningitisSubarachnoid HemorrhageOthers (Cerebral Edema, CNS Infection, etc.) Make An EnquiryAbout This Report @ https://www.marketresearchhub.com/enquiry.php?type=E&repid=2559093&source=atm Scope of The Intracranial Pressure(ICP) Monitoring Market Report: This research report for Intracranial Pressure(ICP) Monitoring Market explores different topics such as product scope, product market by end users or application, product market by region, the market size for the specific product Type, sales and revenue by region forecast the Market size for various segments. The Report provides detailed information regarding the Major factors (drivers, restraints, opportunities, and challenges) influencing the growth of the Intracranial Pressure(ICP) Monitoring market. The Intracranial Pressure(ICP) Monitoring Market Report analyzes opportunities in the overall Intracranial Pressure(ICP) Monitoring market for stakeholders by identifying the high-growth segments. A detailed overview of the geographical and competitive sphere of the Intracranial Pressure(ICP) Monitoring market: You can Buy This Report from Here @ https://www.marketresearchhub.com/checkout?rep_id=2559093&licType=S&source=atm Table of Content of The Report Chapter 1- Intracranial Pressure(ICP) Monitoring Industry Overview: 1.1 Definition of Intracranial Pressure(ICP) Monitoring Chapter 3- Sales Market Analysis: Chapter 6- Major Manufacturers Production and Sales Market Comparison Analysis Chapter 7- Major Classification Analysis Chapter 8- Major Application Analysis Chapter 9- Industry Chain Analysis: 2020 Injectable Nanomedicines Market Demand Analysis, Statistics, Trends and Investment Opportunities to 2023 - Fusion Science Academy Commentary: AI can’t resolve the ambiguities of early cancer diagnosis – Austin American-Statesman § January 19th, 2020 § Filed under Nano Medicine Comments Off on Commentary: AI can’t resolve the ambiguities of early cancer diagnosis – Austin American-Statesman The new decade opened with some intriguing news: the journal Nature reported that artificial intelligence was better at identifying breast cancers on mammograms than radiologists. Researchers at Google Health teamed up with academic medical centers in the United States and Britain to train an AI system using tens of thousands of mammograms. But even the best artificial intelligence system cant fix the uncertainties surrounding early cancer diagnosis. To understand why, it helps to have a sense of how AI systems learn. In this case, the system was trained with images labeled as either cancer or not cancer. From them, it learned to deduce features from the images such as shape, density and edges that are associated with the cancer label. Thus, the process is wholly dependent on starting with data that are correctly labeled. In the AI mammography study, the initial diagnoses were determined by a pathologist who examined breast biopsy specimens under a microscope after an abnormal mammogram. In other words, the pathologist determined whether the mammogram showed cancer or not. Unfortunately, this pathologic standard is problematic. Over the last 20 years there has been a growing recognition that screening mammography has led to substantial overdiagnosis the detection of abnormalities that meet the pathological definition of cancer, yet are not destined to ever cause symptoms or death. Furthermore, pathologists can disagree about who has breast cancer even when presented with the same biopsy specimens under the microscope. The problem is far less for large, obvious cancers far greater for small (even microscopic), early-stage cancers. Thats because there is a gray area between cancer and not cancer. This has important implications for AI technology used for cancer screening. AI systems will undoubtedly be able to consistently find subtle abnormalities on mammograms, which will lead to more biopsies. This will require pathologists to make judgments on subtler irregularities that may be consistent with cancer under the microscope, but may not represent disease destined to cause symptoms or death. In other words, reliance on pathologists for the ground truth could lead to an increase in cancer overdiagnosis. The problem is not confined to breast cancer. Overdiagnosis and disagreement over what constitutes cancer are also problems relevant to melanoma, prostate and thyroid cancer. AI systems are already being developed for screening skin moles for melanoma and are likely to be employed in other cancers as well. In a piece for the New England Journal of Medicine last month, we proposed a better way of deploying AI in cancer detection. Why not make use of the information contained in pathological disagreement? We suggested that each biopsy used in training AI systems be evaluated by a diverse panel of pathologists and labeled with three distinct categories: unanimous agreement of cancer, unanimous agreement of not cancer, and disagreement as to the presence of cancer. This intermediate category of disagreement would not only help researchers understand the natural history of cancer, but could also be used by clinicians and patients to investigate less invasive treatment for cancers in the gray area. The problem of observer disagreement is not confined to pathologists; it also exists with radiologists reading mammograms. Thats the problem AI is trying to solve. Yet, while the notion of disagreement may be unsettling, disagreement also provides important information: Patients diagnosed with an early-stage cancer should be more optimistic about their prognoses if there were some disagreement about whether cancer was present, rather than all pathologists agreeing it was obviously cancer. Artificial intelligence cant resolve the ambiguities surrounding early cancer diagnosis, but it can help illuminate them. And illuminating these gray areas is the first step in helping patients and their doctors respond wisely to them. We believe that training AI to recognize an intermediate category would be an important advance in the development of this technology. Adamson is a dermatologist and assistant professor of internal medicine at Dell Medical School at the University of Texas. Welch is a senior researcher in the Center for Surgery and Public Health at Brigham and Womens Hospital in Boston. Their commentary first appeared in The Los Angeles Times. Visit link: Commentary: AI can't resolve the ambiguities of early cancer diagnosis - Austin American-Statesman Most engineered nanoparticles enter tumours through cells not between them, U of T researchers find – News@UofT § January 19th, 2020 § Filed under Nano Medicine Comments Off on Most engineered nanoparticles enter tumours through cells not between them, U of T researchers find – News@UofT University of Toronto researchers have discovered that an active rather than passive process dictates which nanoparticles enter solid tumours, upending decades of thinking in the field of cancer nanomedicine and pointing toward more effective nanotherapies. The prevailing theory in cancer nanomedicine an approach that enables more targeted therapies than standard chemotherapy has been that nanoparticles mainly diffuse passively into tumours through tiny gaps between cells in the endothelium, which lines the inner wall of blood vessels that support tumour growth. The researchers previously showed thatless than one per centof nanoparticle-based drugs typically reach their tumour targets. In the current study, they found that among nanoparticles that do penetrate tumours, more than 95 per cent pass through endothelial cells not between gaps among those cells. Our work challenges long-held dogma in the field and suggests a completely new theory, saysAbdullah Syed, a co-lead author on the study and post-doctoral researcher in the lab ofWarren Chan, a professor at theInstitute of Biomaterials and Biomedical Engineeringand theDonnelly Centre for Cellular and Biomolecular Research. We saw many nanoparticles enter the endothelial cells from blood vessels and exit into the tumour in various conditions. Endothelial cells appear to be crucial gatekeepers in the nanoparticle transport process. The findings were recently published in thejournalNature Materials. From left to right: U of T researchers Jessica Ngai, Shrey Sindhwani, Abdullah Syed and Benjamin Kingston (photo by Qin Dai) Syed compares nanoparticles to people trying to get into popular restaurants on a busy night. Some restaurants dont require a reservation, while others have bouncers who check if patrons made reservations, he says. The bouncers are a lot more common than researchers thought, and most places only accept patrons with a reservation. The researchers established that passive diffusion was not the mechanism of entry with multiple lines of evidence. They took over 400 images of tissue samples from animal modelsand saw few endothelial gaps relative to nanoparticles. They observed the same trend using 3D fluorescent imaging and live-animal imaging. Similarly, they found few gaps between endothelial cells in samples from human cancer patients. The group then devised an animal model that completely stopped the transportation of nanoparticles through endothelial cells. This allowed them to isolate the contribution of passive transport via gaps between endothelial cells, which proved to be miniscule. The researchers posit several active mechanisms by which endothelial cells might transport nanoparticles into tumours, including binding mechanisms, intra-endothelial channels and as-yet undiscovered processes all of which they are investigating. Meanwhile, the results have major implications for nanoparticle-based therapeutics. These findings will change the way we think about delivering drugs to tumours using nanoparticles, saysShrey Sindhwani, also a co-lead author on the paper and an MD/PhD student in the Chan lab. A better understanding of the nanoparticle transport phenomenon will help researchers design more effective therapies. The research included collaborators from U of Ts department of physics in the Faculty of Arts & Science, Cold Spring Harbor Laboratory In New York and the University of Ottawa. The study was funded by the Canada Research Chairs Program, Canadian Cancer Society, Natural Sciences and Engineering Research Council of Canadaand the Canadian Institutes of Health Research. Read the rest here: Most engineered nanoparticles enter tumours through cells not between them, U of T researchers find - News@UofT Nanomedical Devices and Therapeutics Market : Information, Figures and Analytical Insights 2012 2018 – Fusion Science Academy § January 19th, 2020 § Filed under Nano Medicine Comments Off on Nanomedical Devices and Therapeutics Market : Information, Figures and Analytical Insights 2012 2018 – Fusion Science Academy The research study presented in this report offers complete and intelligent analysis of the competition, segmentation, dynamics, and geographical advancement of the Global Ultrasonic Dental Devices Market. The research study has been prepared with the use of in-depth qualitative and quantitative analyses of the global Ultrasonic Dental Devices market. We have also provided absolute dollar opportunity and other types of market analysis on the global Ultrasonic Dental Devices market. It takes into account the CAGR, value, volume, revenue, production, consumption, sales, manufacturing cost, prices, and other key factors related to the global Ultrasonic Dental Devices market. All findings and data on the global Ultrasonic Dental Devices market provided in the report are calculated, gathered, and verified using advanced and reliable primary and secondary research sources. The regional analysis offered in the report will help you to identify key opportunities of the global Ultrasonic Dental Devices market available in different regions and countries. The authors of the report have segmented the global Ultrasonic Dental Devices market as per product, application, and region. Segments of the global Ultrasonic Dental Devices market are analyzed on the basis of market share, production, consumption, revenue, CAGR, market size, and more factors. The analysts have profiled leading players of the global Ultrasonic Dental Devices market, keeping in view their recent developments, market share, sales, revenue, areas covered, product portfolios, and other aspects. Note:Although care has been taken to maintain the highest levels of accuracy in TMRs reports, recent market/vendor-specific changes may take time to reflect in the analysis. Ultrasonic Dental Devices Market Size and Forecast In terms of region, this research report covers almost all the major regions across the globe such as North America, Europe, South America, the Middle East, and Africa and the Asia Pacific. Europe and North America regions are anticipated to show an upward growth in the years to come. While Ultrasonic Dental Devices Market in Asia Pacific regions is likely to show remarkable growth during the forecasted period. Cutting edge technology and innovations are the most important traits of the North America region and thats the reason most of the time the US dominates the global markets. Ultrasonic Dental Devices Market in South, America region is also expected to grow in near future. RequestTOC For ThisReport @ https://www.transparencymarketresearch.co/sample/sample.php?flag=T&rep_id=65882 The Ultrasonic Dental Devices Market report highlights is as follows: This Ultrasonic Dental Devices market report provides complete market overview which offers the competitive market scenario among major players of the industry, proper understanding of the growth opportunities, and advanced business strategies used by the market in the current and forecast period. This Ultrasonic Dental Devices Market report will help a business or an individual to take appropriate business decision and sound actions to be taken after understanding the growth restraining factors, market risks, market situation, market estimation of the competitors. The expected Ultrasonic Dental Devices Market growth and development status can be understood in a better way through this five-year forecast information presented in this report This Ultrasonic Dental Devices Market research report aids as a broad guideline which provides in-depth insights and detailed analysis of several trade verticals. Transparency Market Research (TMR) is a global market intelligence company providing business information reports and services. The companys exclusive blend of quantitative forecasting and trend analysis provides forward-looking insight for thousands of decision makers. TMRs experienced team of analysts, researchers, and consultants use proprietary data sources and various tools and techniques to gather and analyze information. Mr. Rohit BhiseyTransparency Market ResearchState Tower90 State Street,Suite 700,Albany, NY 12207United StatesTel: +1-518-618-1030USA Canada Toll Free: 866-552-3453Email: [emailprotected]Website: http://www.transparencymarketresearch.com Nanomedical Devices and Therapeutics Market : Information, Figures and Analytical Insights 2012 2018 - Fusion Science Academy At US$ 300 Mn Reached Injectable Nanomedicines Market With 8.2% CAGR Value In The Year of 2026 – Fusion Science Academy § January 19th, 2020 § Filed under Nano Medicine Comments Off on At US$ 300 Mn Reached Injectable Nanomedicines Market With 8.2% CAGR Value In The Year of 2026 – Fusion Science Academy At US$ 300 Mn Reached Injectable Nanomedicines Market With 8.2% CAGR Value In The Year of 2026 - Fusion Science Academy Microscopic Colitis Diet, Treatment, Symptoms & Causes § January 19th, 2020 § Filed under Nano Medicine Comments Off on Microscopic Colitis Diet, Treatment, Symptoms & Causes What is colitis? Colitis means inflammation of the colon. The colon, also known as the large intestine or large bowel, constitutes the last part of the digestive tract. The colon is a long, muscular tube that receives digested food from the small intestine. It removes water from the undigested food, stores the undigested food, and then eliminates it from the body through bowel movements. The rectum is the last part of the colon adjacent to the anus. The common symptoms of colitis include: There are many different types of colitis with different causes. Some examples of colitis include: Infectious, radiation, ischemic, ulcerative, and Crohn's colitis all have visible abnormalities of the inner lining of the colon. These abnormalities include edema (swelling of the lining), redness, bleeding from the lining with gentle rubbing (friability), and ulcers. These abnormalities can be seen duringcolonoscopy (examination of the entire colon using a long flexible viewing tube) or flexible sigmoidoscopy (examination of the rectum and the sigmoid colon - the segment of the colon closest to the rectum). Edema and inflammation of the colon's lining interferes with the absorption of water from the undigested food, and the unabsorbed water exits the rectum as diarrhea. Pus and fluid also are secreted into the colon and add to the diarrhea. The redness, bleeding from the lining with gentle rubbing (friability), and ulcerations in the lining of the colon contribute to the rectal bleeding. What diseases are not colitis? Individuals with irritable bowel syndrome (IBS) do not have colitis, even though this condition is sometimes referred to as having "spastic colitis." These individuals may have symptoms that mimic colitis such as diarrhea, abdominal pain, and mucus in stool. Nevertheless, there is no inflammation of the colon in patients with IBS. The cause of symptoms in IBS is not clearly known; it may be caused by either abnormal motility (abnormal contractions) of the intestinal muscles or abnormally sensitive nerves in the intestines (visceral hypersensitivity). What is microscopic colitis? Microscopic colitis refers to inflammation of the colon that is only visible when the colon's lining is examined under a microscope. The appearance of the inner colon lining in microscopic colitis is normal by visual inspection during colonoscopy or flexible sigmoidoscopy. The diagnosis of microscopic colitis is made when a doctor, while performing colonoscopy or flexible sigmoidoscopy, takes biopsies (small samples of tissue) of the normal-appearing lining, and then examines the biopsies under a microscope. There are two types of microscopic colitis: 1) lymphocytic colitis and 2) collagenous colitis. Some experts believe that lymphocytic colitis and collagenous colitis represent different stages of the same disease. The inflammation and the collagen probably interfere with absorption of water from the colon, resulting in the diarrhea. What are the symptoms of microscopic colitis? The primary symptom of microscopic colitis is chronic, watery diarrhea. Individuals with microscopic colitis can have diarrhea for months or years before the diagnosis is made. Typically, the symptoms begin very gradually and are intermittent in nature with periods when the person feels well, followed by bouts of chronic diarrhea. This chronic diarrhea of microscopic colitis is different from the acute diarrhea of infectious colitis, which typically lasts only days to weeks. Some individuals with microscopic colitis also may experience mild abdominal cramps and pain. Blood in the stool is unusual. How common is microscopic colitis and who is at risk? The prevalence of microscopic colitis in the U.S. is not clearly known. Microscopic colitis most commonly occurs in the middle aged and elderly patients and is more common among women than men. When should I seek medical care for microscopic colitis? A person should seek medical care if the diarrhea lasts for more than 2 weeks or is accompanied with symptoms such as weight loss, fatigue, and abdominal pain. How is microscopic colitis diagnosed? The diagnosis of microscopic colitis is made by performing biopsies from different regions of the colon during colonoscopy or sigmoidoscopy. The abnormalities of the colon's lining in microscopic colitis occur in a patchy distribution (areas of normal lining may coexist adjacent to areas of abnormal lining). For this reason, multiple biopsies should be taken from several different regions of the colon in order to accurately make a diagnosis. The patchy nature of microscopic colitis also is the reason why flexible sigmoidoscopy often is inadequate in diagnosing the condition because the abnormalities of microscopic colitis may be absent from the sigmoid colon (the colonic segment that is closest to the rectum and is within the reach of a sigmoidoscope) in some of the patients with microscopic colitis. Thus, biopsies of other regions of the colon accessible only with colonoscopy may be necessary for diagnosing microscopic colitis. What is the treatment for microscopic colitis? The treatment of microscopic colitis has not been standardized because there have not been adequate large scale, prospective, placebo controlled treatment trials. The following strategies are safe and may relieve diarrhea in some patients: Controlled trials showed that budesonide (Entocort, a poorly absorbed steroid) is effective in controlling diarrhea in more than 75% of the patients with collagenous colitis, but the diarrhea tends to recur soon after stopping Entocort. Though data supporting their use is lacking, some doctors may use medications that potently suppress the immune system such as azathioprine (Imuran, Azasan) and 6-mercaptopurine in patients with severe microscopic colitis that is unresponsive to other treatments. Can microscopic colitis be prevented? Since the cause of microscopic colitis is not known, no advice can be provided about preventing this disease. What is the prognosis of microscopic colitis? The long term prognosis (course) of microscopic colitis is not clear. In approximately two-thirds of the patients with microscopic colitis, the diarrhea resolves spontaneously after several years. The remaining one-third of the patients with microscopic colitis experience persistent or intermittent diarrhea and/or abdominal pain for many years (possibly indefinitely) as there is no cure for the condition. By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time. MedscapeReference.com. Collagenous and Lymphocytic Colitis. R H Riddell, M Tanaka, and G Mazzoleni. Non-steroidal anti-inflammatory drugs as a possible cause of collagenous colitis: a case-control study. Gut. 1992 May; 33(5): 683686. Someone just built microscopic robots from living cells, and its Westworld-level creepy – SYFY WIRE § January 17th, 2020 § Filed under Nano Medicine Comments Off on Someone just built microscopic robots from living cells, and its Westworld-level creepy – SYFY WIRE Someone just built microscopic robots from living cells, and its Westworld-level creepy SYFY WIRE Worlds First Living Robot Invites New Opportunities And Risks Forbes A research team builds robots from living cells The Economist Tiny 'living robots' made from FROG embryos could be used to destroy cancer cells Daily Mail View post: Someone just built microscopic robots from living cells, and its Westworld-level creepy - SYFY WIRE Adamson, Welch: Using artificial intelligence to diagnose cancer could mean unnecessary treatments – St. Paul Pioneer Press § January 17th, 2020 § Filed under Nano Medicine Comments Off on Adamson, Welch: Using artificial intelligence to diagnose cancer could mean unnecessary treatments – St. Paul Pioneer Press But even the best artificial intelligence system cant fix the uncertainties of early cancer diagnosis. To understand why, it helps to have a sense of how AI systems learn. In this case, the system was trained with images labeled as either cancer or not cancer. From them, it learned to deduce features such as shape, density and edges that are associated with the cancer label. Thus, the process is dependent on starting with data that are correctly labeled. In the AI mammography study, the initial diagnoses were determined by a pathologist who examined biopsy specimens under a microscope after an abnormal mammogram. In other words, the pathologist determined whether the mammogram showed cancer. Unfortunately, this pathologic standard is problematic. Over the last 20 years there has been a growing recognition that screening mammography has led to substantial overdiagnosis the detection of abnormalities that meet the pathological definition of cancer, yet wont ever cause symptoms or death. Adewole S. Adamson is a dermatologist and assistant professor of medicine at Dell Medical School at the University of Texas at Austin. H. Gilbert Welch is a senior researcher in the Center for Surgery and Public Health at Brigham and Womens Hospital in Boston and author of Should I Be Tested for Cancer? Maybe Not and Heres Why. They wrote this piece for the Los Angeles Times. Adamson, Welch: Using artificial intelligence to diagnose cancer could mean unnecessary treatments - St. Paul Pioneer Press Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries – Science Advances § January 17th, 2020 § Filed under Nano Medicine Comments Off on Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries – Science Advances Microcirculatory obstruction is a hallmark of severe malaria, but mechanisms of parasite sequestration are only partially understood. Here, we developed a robust three-dimensional microvessel model that mimics the arteriole-capillary-venule (ACV) transition consisting of a narrow 5- to 10-m-diameter capillary region flanked by arteriole- or venule-sized vessels. Using this platform, we investigated red blood cell (RBC) transit at the single cell and at physiological hematocrits. We showed normal RBCs deformed via in vivolike stretching and tumbling with negligible interactions with the vessel wall. By comparison, Plasmodium falciparuminfected RBCs exhibited virtually no deformation and rapidly accumulated in the capillary-sized region. Comparison of wild-type parasites to those lacking either cytoadhesion ligands or membrane-stiffening knobs showed highly distinctive spatial and temporal kinetics of accumulation, linked to velocity transition in ACVs. Our findings shed light on mechanisms of microcirculatory obstruction in malaria and establish a new platform to study hematologic and microvascular diseases. Microcirculatory disorders are associated with both infectious and noninfectious diseases, including Plasmodium falciparum malaria (1), sickle cell disease (2), and type 2 diabetes (3). Sequestration of P. falciparuminfected red blood cells (IRBCs) in the microcirculation has been recognized as a critical event in severe malaria pathogenesis and associated life-threatening complications, leading to approximately 500,000 deaths per year (4, 5). During the blood stage of infection, P. falciparum parasites extensively modify the host erythrocyte cytoskeleton and membrane, resulting in altered red blood cell (RBC) deformability and new adhesive properties. In particular, IRBCs display knob-like surface protrusions that stiffen the erythrocyte membrane (6, 7) and present the P. falciparum erythrocyte membrane protein 1 (PfEMP1) ligands that mediate cytoadhesion to the vascular endothelium (8, 9). Both knobs and PfEMP1 are thought to contribute to IRBC sequestration, giving rise to enhanced disease severity through small vessel occlusion, tissue ischemia, and eventual organ failure (1, 8, 1013). In addition, sequestered IRBCs may localize host or parasite-derived products that contribute to endothelial dysfunction and organ damage (14). Worldwide deaths attributed to malaria remain high, even after the introduction of more effective, faster-acting, antimalaria drugs (15). Investigating disease mechanisms and new therapeutic approaches to combine with antimalaria drugs has proven challenging as P. falciparum is a human tropic pathogen with complications focused at the capillary and postcapillary venule (16, 17). As no proper in vitro human capillary model exists, inferences must instead be drawn from postmortem analysis or studies in non-natural hosts [primate infections (18) or ex vivo rat microcirculatory models (12)], in which host receptors are not the natural binding partners for P. falciparum ligands. Within the microcirculation, RBCs (diameter dAVG = 7.5 m) deform as they traverse capillaries (dAVG = 3 to 10 m) that are often narrower than their resting-state diameters. To understand how the altered deformability of P. falciparumIRBCs contributes to microcirculatory obstruction, the mechanics of RBC flow have been modeled in vitro using narrow glass tubes or wedge-shaped, rigid PDMS (polydimethylsiloxane)based microfluidic devices (1924). While these approaches have demonstrated geometric thresholds for mechanical trapping of IRBCs (20, 25), they do not account for either the lubricating properties of the endothelial glycocalyx or the adhesive contributions of endothelial cells (26, 27). Conversely, flow-based, endothelial monolayer models have investigated the role of different host receptors in parasite cytoadhesion (2830), yet they are unable to capture the geometric constraints that govern IRBC flow through narrow capillary constrictions or the flow rate transitions encountered as cells traverse different-size microvessels. The altered adhesive and mechanical properties of IRBCs and the alterations in flow dynamics experienced by IRBCs within microvessels likely all contribute to sequestration in a mutually dependent manner. Without an adequate human capillary model, the contributions of these biophysical and biochemical factors of IRBC sequestration cannot be explored. We addressed these challenges by developing a three-dimensional (3D) arteriole-capillary-venule (ACV) microvessel unit, in which endothelial cells are grown in a native extracellular matrix. After optimizing the design parameters of 3D capillary fabrication and endothelialization, we used the ACV unit to identify the distinct spatiotemporal dynamics of RBC capillary transit and dissect the individual contributions of cytoadhesion and mechanical stiffening to IRBC sequestration. Our study sheds light on the mechanisms underlying IRBC sequestration during severe malaria infection and provides a unique platform to study the cellular, microfluidic, and geometric factors that give rise to microvascular obstruction in hematologic diseases. To create an efficient capillary model, we first fabricated an acellular 3D ACV microvessel unit via a two-step process. First, large arteriole or venule-sized microchannels (lumen diameter d = 200 m, spaced 450 m apart) were lithographically fabricated in collagen hydrogels (7.5 mg/ml, ~200 to 500 Pa), as previously described (31). Then, an array of capillary-sized microchannels or features of arbitrary user-defined geometries (32) were generated between the two main channels using multiphoton microscopyguided femtosecond laser photoablation (fig. S1A). Ablated regions were confirmed using second harmonic imaging of collagen fibers (fig. S1B). Arrays of channels ranging from 5 to 20 m in diameter were rapidly produced (~75 channels/hour) with high density and robust perfusability by 0.22-m fluorescent beads (fig. S1, C and D). The density generated (~11,600 channels/mm2 for 5-m arrays; fig. S1D) can reach a similar or higher level than that observed in the human heart [1100 capillaries/mm2 in vivo; (33)]. Endothelialization of this ACV model posed substantial challenges as conventional methods of cell seeding after microvessel fabrication (31) led to sparse endothelial coverage within the microchannel arrays and nonperfusable vessels even after 7 days of culture. Successful endothelialization was achieved by leveraging the precise yet destructive nature of photoablation to simultaneously incur local endothelial cell injury while generating capillary-sized void spaces between two preformed main microvessels (Fig. 1A). This methodology encouraged endothelial cell migration and ingrowth into the ablated channels (Fig. 1B). Stable endothelial coverage was observed in the capillary-sized channels as early as 18 hours following photoablation (Fig. 1C and movie S1), and complete endothelialization of 20-m channels was observed after 4 days of culture under gravity-driven flow across the microvessels (Fig. 1B). (A) Diagram of device assembly and capillary fabrication. Main channels were generated by soft lithography in acrylic jigs followed by capillary generation by photoablation and endothelial ingrowth. (B) Array (2 2) of 20-m-diameter vessels demonstrates stable vessel lumens. Green: F-actin; blue: nuclei. (C) Endothelial ingrowth over 18 hours demonstrates complete vessel formation. (D and E) Cryosectioned capillaries were stained with (D) hematoxylin and eosin as well as (E) type IV collagen, demonstrating lumen formation by single endothelial cells and robust basement membrane deposition. (F) Constriction vessel design allows for the generation of sub10-m-diameter capillaries shown in both projected and cross-sectional views. Red: VE-cadherin; blue: nuclei. (G to I) Ultrastructural analysis of capillary vessel regions by transmission electron microscopy (TEM) shows vessels at varying diameters (from 40 to 10 m) in cross-sectional (G and I) and longitudinal (H) views and varying wall thicknesses and junctions at cell-cell contact in zoomed views (I). Cross-sectional views of vessel regions near the connection. Col: collagen substrate; : lumen; C: cells. (J) Stitched confocal image demonstrates complete vessel network consisting of 33 capillaries. Green: von Willebrand factor; blue: nuclei; red: VE-cadherin; purple: F-actin. In vivo, capillary lengths range from 150 to 500 m (34). To determine the vessel patency at high vessel density, 2 2 arrays of straight channels, consisting of either 10- or 20-m lumen diameters spaced 5, 10, or 20 m apart, were photoablated between two preformed main microvessels of 200-m diameter (fig. S2). Microchannels that were initially separated by only 5 or 10 m demonstrated partial or complete fusion after endothelial cell ingrowth from the two main microvessels, leading to a larger vessel diameter (fig. S2, B and C). By comparison, microchannels of 20-m diameter separated by a 20-m distance maintained high vessel diameter fidelity (Fig. 1B and fig. S2C), Whereas 10-m diameter channels exhibited incomplete endothelialization and patchy endothelial coverage (fig. S2B), vascularization was more efficient in 20-m channels. The average length of continuous endothelium in 10-m diameter channels was approximately 126.7 60.2 m, corresponding to an aspect ratio [AR = length (l): lumen diameter (d) of 12.7 6.0] (fig. S2D). In contrast, 20-m-diameter vessels demonstrated near-complete endothelialization (365 105.4 m) (AR = 18.3 5.3). Moreover, 20-m-diameter vessels exhibited clear lumens upon histological staining and deposited abundant type IV collagen, suggesting the generation of a robust basement membrane (Fig. 1, D and E). Together, these data suggest geometric constraints for small vessel size formation (a minimum distance of 20 m between two parallel small channels and maximum AR of approximately 12 to 18) to maintain vessel patency, which has consistent range with human in vivo measurements for the length-to-diameter ratio (33). In vivo, RBCs experience changes in velocity as they traverse different-sized microvessels within the ACV unit (35). To build a robust capillary model at smaller diameters (5 to 10 m) that more accurately mimics the in vivo vascular tree, we designed a constriction-shaped ACV geometry with a gradual change of diameter and a reduced AR for the capillary regions. This design consisted of five distinct regions that combine to form a symmetric hourglass shape: a precapillary arteriole and a postcapillary venule mimicking vessels with constant width (w = 40 m, l = 80 m, thereby AR = 2), which were connected to a capillary-sized region (w = 5 m, l = 80 m, AR = 16) by two flanking narrowing/expanding transition regions (w = 40 to 5 m, l = 105 m). This vessel design decreased the length of the capillary-sized region and increased the width or diameter of the sections that connected with the two main larger-sized microvessels, therefore promoting endothelial cell ingrowth and capillary patency (Fig. 1, F to J). Two cell seeding approaches were tested for endothelialization efficiency and perfusability: (i) direct cell seeding of fully acellular channels followed by 7 days of culture and (ii) photoablation-guided capillary ingrowth for 4 days from two large preformed main vessels after 3 days of culture (7 days total). The hourglass-shaped ACV unit design supported robust endothelial cell ingrowth throughout the capillary-sized channels using both seeding approaches (fig. S3, A to D). While successful endothelialization could be achieved using either of the seeding methods (65 1% versus 77 7%, mean SEM), the percentage of perfusable capillaries was significantly higher when endothelial cells grew into the photoablated channels from preformed microvessels (57 12% versus 17 7%, mean SEM, **P < 0.002) (fig. S3E). Implementation of photoablation-guided capillary ingrowth resulted in robust, consistent, and perfusable capillary-sized microvessels of 5- to 10-m diameter, measured via confocal microscopy (Fig 1, F to J, and fig. S3, A and B). Similar to the two main vessels, the endothelium within the ACV regions was positive for vascular endothelial (VE)cadherin (a marker of intercellular junctions) and von Willebrand factor (a marker of Weibel-Palade bodies) (Fig. 1, F to J). We further measured the diameter at the narrowest region of the capillary constriction zones, which ranged from 7.5 to 13.6 m (10.9 1.8 m, mean SD, n = 25 capillaries) in confocal microscopy and 5.6 to 13.2 m (8.6 2.1 m, mean SD, n = 15 capillaries) in two-photon microscopy. Electron microscopic analysis confirmed the gradual changes of vessel diameter along the longitudinal direction (Fig. 1, G to I, and fig. S4). Ultrastructure of vessel regions with cross-sectional diameters larger than 20 m was often formed from two or more endothelial cells, connected with focal contacts and junctions between surrounding cells (Fig. 1, G1 and G2). By comparison, at regions of 10 m or smaller in diameter, lumens appeared to be enclosed by a single endothelial cell, which formed extensive focal contacts and complex junctions with overlapping cell peripherals from one or two neighboring cells (Fig. 1, G3). The lumenal wall displayed heterogeneous thickness, ranging from approximately 100 nm to several micrometers at the regions of cell bodies or overlapping cell regions. This also led to varying vessel diameters in both longitudinal and circumferential directions across the ACV unit, although vessels remained intact and continuous across almost all planes examined (Fig. 1, G and H, and fig. S4). Together, our data suggest an efficient approach to fabricate a continuous, endothelialized, perfusable ACV unit with high fidelity and patency. (A) Superimposed time lapse image series of RBC motion through an endothelialized vessel. Time lapse interval: 0.1 s. Scale bar, 25 m. (B) Schematic showing RBC perfusion through constriction-shaped vessel. wc = 10 m; wm = 40 m. (C) Representative examples of parachute-, slipper-, and discocyte-like RBC deformations in capillary constrictions. Scale bar, 10 m. (D) Representative traces of RBC major axis length and orientation for (i) stretching and (ii) tumbling RBCs, where x = 0, y = 0 is the center of the capillary; gray boxes: capillary extents. (E) Normalized extent of deformation, defined as the ratio of major axis length at a given position to the average major axis length in the precapillary region for (i) normal RBCs and (ii) knobless malaria-IRBCs (n = 3; each biological replicate is represented by one symbol, , , , or ). When normal RBCs were perfused through the completely endothelialized ACV devices at full hematocrit, the presence of endothelium appeared to facilitate the smooth perfusion of RBCs through the capillary constriction region (movie S2). By comparison, in acellular collagen microchannels with the same hourglass geometry, RBCs accumulated upstream before entering the narrowest region, leading to local increases of hematocrit, as well as intermittent jetting of RBCs into the capillary constriction zones and much lower hematocrit further downstream (movie S3). This comparison of acellular and endothelialized microvessels reinforces the importance of the endothelium in understanding the interaction of RBCs and capillaries. We next exploited this endothelialized capillary model to study the biomechanical and functional differences between normal and infected RBCs under flow. To allow visualization of individual cells as they traverse the ACV units, RBCs were perfused at a low hematocrit. When normal RBCs were perfused through ACVs at low hematocrit and velocities similar to in vivo capillary flow rates (250 to 1500 m/s) (34, 36), they displayed in vivolike stretching in the capillary region and tumbling behavior in the pre- and postcapillary regions (Fig. 2, A and B, and movies S4 and S5). Normal RBCs readily traversed the capillary regions down to 5 m in diameter and assumed a variety of deformations, including parachute-like, slipper-like, and discocyte shapes (Fig. 2C), in agreement with previous in vivo observations (19), computational simulations (37, 38), and microfluidic studies in narrow glass tubes (38). Using edge detectionbased image analysis (see the Supplementary Materials and Methods and fig. S5), we tracked the position, velocity, shape, and orientation of individual RBCs throughout the capillaries (Fig. 2D). Normal RBCs showed two major modes of motion in the capillary regions: elongation, characterized by stretching along the major axis by up to twofold (Fig. 2D (i) and movie S4), and tumbling, characterized by oscillations in major axis orientation (Fig. 2D (ii) and movie S5). Compared with normal RBCs, P. falciparumIRBCs present increased rigidity due to knob-like modifications to the erythrocyte cytoskeleton (6, 7) and modest changes in RBC volume and its biconcave shape due to the growing intracellular parasite (39), which might change the IRBC mechanics through capillary-sized vessels. To understand how the intracellular parasite body contributes to the biomechanics of IRBC traversal through the microcirculation, independently of knob rigidification and cytoadhesion, we perfused a clonally derived parasite variant called 2G2 (fig. S6), which has been selected for lack of knobs by gelatin (40). Although not statistically different compared with normal RBCs, 2G2-IRBCs presented minimal elongation and mostly tumbled through the capillary region despite being perfused at similar velocities to normal RBCs (Fig. 2E and movie S6). Because rolling and tumbling along the microvascular endothelium enhance cytoadhesion and increase the probability of ligand-receptor interaction at high shear stress (41), we expect that these differences in tumbling motion may enhance the ability of malaria-infected RBCs to both be mechanically trapped and cytoadhere in capillaries. In the microcirculation, hydrodynamic forces encourage separation and margination of IRBCs from their uninfected RBC counterparts toward the vessel wall, enhancing cytoadhesive interactions with endothelial cells (42, 43). To investigate whether IRBCs sequester at physiological hematocrit concentrations (Fig. 3A), fluorescently labeled IRBCs (0.4 to 4% parasitemia) or normal RBCs were perfused at 40% hematocrit using gravity-driven flow, leading to an average flow rate at approximately 0.002 l/min in each capillary during the first 30 min of perfusion. The cell accumulation was assessed at 1, 4, 7, and 20 min by fluorescence imaging and was compared with flow modeling to relate predicted flow dynamic changes across the microvessels to retention and occlusion events (Fig. 3, B and C). Normal RBCs traversed the entire constriction zone with minimal sequestration in any vessel region (Fig. 3, C to I, and movie S7). Both labeled and unlabeled normal RBCs deformed as necessary to pass through the narrowest regions, suggesting that the membrane-labeling procedure did not significantly increase sequestration potential. By comparison, IT4VAR19, a knob-positive (K+) and cytoadherent parasite variant (PfEMP1+) (fig. S6) (44) displayed steady accumulation (Fig. 3C (ii) and movie S8). Kinetic video analysis demonstrated sequestration throughout the capillary constriction zone with highest accumulation in the first half. Complete occlusion of the capillary region could be observed within minutes after initiation of flow, followed by accumulation of fluorescent IRBCs upstream of the blockage. At end point, K+PfEMP1+ IRBCs demonstrated high fluorescent signals centered in the capillary region and extending into the post- and precapillary regions. Ultrastructural analysis showed that the capillary regions contained a mixture of both infected and normal RBCs (fig. S7, A and B), suggesting that occluded vessels may trap normal RBCs. By transmission electron microscopy (TEM), IRBCs were found in close apposition to lumenal walls, even following perfusion washing (fig. S7). Moreover, some IRBCs were trapped or encircled by the endothelial cell membranes (fig. S7) or appeared to have been fully engulfed by an endothelial cell (fig. S7B), as observed previously in monolayer assays with immortalized endothelial cells (45). (A) Bright-field image of RBCs flowing through a constriction vessel. Dotted lines demonstrate capillary outline trace. (B) Flow velocity model of a single capillary based on fabrication dimensions. (C) Left: Schematic illustrations of the different types of perfused RBCs and IRBCs. Middle: Representative image of binding kinetics within the capillary constriction zones. IRBCs are shown in red. Right: Spatial distribution of accumulation after 20 min of perfusion represented by a combined heat map of average fluorescence from multiple experiments. Normal RBC (n = 24), IT4VAR19 (n = 26), trypsinized IT4VAR19 (n = 19), and 2G2 (n = 19). (D and E) Quantification of average intensity as a measure of x position (D) and comparison among precapillary, capillary, and postcapillary regions (E). n = 24, 26, 17, and 19 ACV units quantified from N = 4 independent experiments for each condition of perfusion: normal RBC, IT4VAR19, trypsinized IT4VAR19, and 2G2, respectively. Analysis of variance (ANOVA) F = 11.61, P < 0.00001 for precapillary region, ANOVA F = 47.83, P < 0.00001 for capillary region, and ANOVA F = 6.41, P < 0.001 for postcapillary region. To elucidate the relative contributions of altered adhesive and mechanical properties in IRBC microvessel obstruction, we trypsinized IT4VAR19 IRBCs to remove the surface presentation of PfEMP1s while leaving the knobs intact (K+PfEMP1) (fig. S8). Previous work by atomic force microscopy has established that P. falciparum knobs are unaffected by trypsin treatment (46). Following trypsinization, there was a marked loss of antibody recognition with two polyclonal antibody reagents against the first and fourth DBL domains in the IT4VAR19 PfEMP1 variant (fig. S8). Perfusion of K+PfEMP1 IRBCs demonstrated minimal sequestration throughout the constriction zone, with binding levels similar to normal RBCs in all vessel regions (Fig. 3, C to E, and movie S9). These findings suggest that while mechanical stiffening may contribute to IRBC margination toward the vessel wall in the postcapillary regions (43), surface-active PfEMP1 is necessary to cause IRBC sequestration. Furthermore, despite the geometric confinement in capillaries, mechanical stiffening on its own is insufficient to induce the same trapping in the 5- to 10-m capillary-sized constrictions observed with the K+PfEMP1+ IRBCs. We next perfused 2G2 (K) to better understand the contribution of knobs to cytoadhesion (40), as they are thought to enhance PfEMP1-mediated adhesion (9, 12, 47) and increase the mechanical stiffening of IRBCs (48). Notably, both IT4VAR19 and 2G2 express endothelial protein C receptor (EPCR)binding var transcripts (49), but 2G2 exhibits much weaker cytoadhesive capabilities under flow conditions (50). Although the weakly adherent 2G2 parasites (K) exhibited higher sequestration rates than the trypsinized IT4VAR19 (K+PfEMP1), cell accumulation was concentrated to the second half of the capillary constriction zone, where cells would experience deacceleration and less flow shear as they transition into the larger-diameter region (Fig. 3, C and D, and movie S10). Together, this analysis identifies distinct and independent contributions of the microcirculatory hemodynamics and parasite-induced modifications to RBCs in microvascular obstruction. Cytoadhesion of P. falciparumIRBCs is a major virulence determinant, but knowledge gaps exist in how parasites cause microvascular obstruction, and the ability to study important human microcirculatory disorders in vitro has been limited to nondeformable glass or microfluidic chamber platforms. Here, we describe an efficient fabrication approach for engineering robust and patent capillary arrays in an ACV unit. Our studies exploited this model to investigate normal and malaria-infected RBCs under perfusion and to identify sequential events of biomolecular and biophysical interactions between RBCs and capillary walls that led to parasite sequestration and microvascular occlusion. Whereas normal RBCs readily traversed the narrow capillary constriction zones, P. falciparumIRBCs rapidly accumulated in these regions. Our study identified distinct contributions of parasite-induced knobs and cytoadhesion ligands in cell accumulation by perfusing IRBCs with different knob structures and trypsinized IRBCs to preserve the knob structure while eliminating the cytoadhesion effects (46). Although trypsinized IRBCs with cleaved parasite cytoadhesion ligands exhibited limited accumulation in the capillary constriction regions, parasites lacking knobs accumulated at the capillary-venule transition where flow rates were deaccelerating. The efficient traversal of trypsinized IRBCs through narrow constrictions is consistent with previous microfluidic studies, which demonstrate mechanical trapping of IRBCs only in nondeformable channels below 4 m in diameter (20). Knob membrane stiffening more likely contributes to splenic elimination, where interendothelial slits are as narrow as 3 m (51, 52). The knob-like protrusions anchor both the PfEMP1 cytoplasmic tail and erythrocyte cytoskeleton components, and previous work has established that they contribute to both parasite cytoadhesion strength (9) and the altered mechanical properties of P. falciparumIRBCs (48) and thereby provide mechanical stability to the interactions between PfEMP1 and endothelial cells. In addition, by positioning the PfEMP1 cytoadhesion ligands above the cell body (53), knobs may also facilitate adhesion. With the distinct spatiotemporal binding of knobless parasites, our findings suggest that PfEMP1 physiological display in knobs facilitates IRBC capture from circulation, particularly in regions of higher flow shear in the capillary constriction area. This is consistent with previous work in ex vivo rat microcirculatory models and primate studies (12, 47). Moreover, our findings reinforce the importance of cell deceleration and lower shear stress as cells exit from the capillaries, in mediating IRBC capture from flow. Postmortem autopsy studies have revealed higher IRBC accumulation rates at the postcapillary region (~3-fold increase as compared with precapillary regions) (17). Thus, our capillary model provides the means to dissect the interdependent interactions of microcirculatory hemodynamics and parasite modifications to malaria obstruction mechanisms. The differences in pre- and postcapillary sequestration have been thought to arise from arterial-venous differences in flow rates or host receptor expression (54); nonetheless, this question has been difficult to study. In an ex vivo rat mesoappendix model, IRBC sequestration initiated in venules and sometimes extended upward by retrograde aggregation into the capillaries and arterioles (12). Although the rat mesoappendix model has been valuable to explore parameters influencing IRBC sequestration, recent work has also shown that severe malaria is linked to EPCR (49, 55, 56), which is highly divergent between humans and rats. Notably, both parasite lines used in this study (IT4VAR19 and 2G2) express EPCR-binding PfEMP1; thus, our human capillary constriction model has advantages in investigating the cytoadherence of severe malaria isolates in an in vitro human model. A limitation of this model is the use of human umbilical cord endothelial cells (HUVECs), a cell type from large-vessel origin. However, HUVECs are commonly used to develop new 3D vascular platforms, and future studies can build on our design principles to incorporate different endothelial cells to develop organ-specific ACV units. In addition, the study of single-cell dynamics is challenging because of the lack of precise flow control in individual capillaries, owing to the parallel nature of many capillaries between the two main vessels in our system and the varying diameters in each capillary, similar to vessels found in vivo. Nevertheless, our ACV unit mimics physiological flow transitions within the microcirculation and could distinguish spatial and temporal binding differences between normal RBCs and IRBCs, as well as between wild-type parasites and parasites lacking PfEMP1 or the knob-like protrusions. Notably, parasite knob densities differ widely between fresh ex vivo parasites (57) and may also be modified in severe malaria infections (58), but it is unknown whether these variations modify IRBC cytoadhesion efficiency or influence disease severity. Our ACV model provides a fundamentally new approach to investigate microvascular obstruction in an in vitro human model. The success sheds light for future therapeutic development in treating blood-stage malaria and provides a potential platform for the studies of other microvascular disorders, such as sickle cell anemia, or in the context of transfusion medicine of blood products. First, two parallel microchannels were fabricated via lithography and injection moldingbased techniques in collagen gel, as described previously (31), to mimic arteriole- and venule-sized vessels. Next, multiphoton photoablation was performed in collagen gel between these two parallel microchannels using a Mai Tai DeepSee Ti:S laser (maximum power, 2.57 W) coupled with an Olympus FV1000MPE BX61 microscope fitted with a water immersion objective lens (25, numerical aperture = 1.05). Microchannels and surrounding collagen regions were first identified by imaging of second-harmonic generation signals produced by collagen microfibers at excitation wavelength ex = 860 nm and detection wavelength detector = 420 to 460 nm. Individual capillary-sized channels were designed within the collagen matrix by designating 3D regions of interest using the Olympus Fluoview software and then ablated by laser rastering ( = 800 nm, I = 100%, pixel dwell time = 2 s, 10 to 15 line repeat scans). Laser scanning in the X, Y, and Z dimensions were performed at ~1-m step sizes. After the ablation, 0.22-m-diameter fluorescent microbeads were perfused from one side of the main channels across the newly created capillary-sized channels to the other side at a pressure drop of 1 cmH2O for 10 min, followed by imaging for evaluation of perfusability (fig. S1). Endothelializing ACV unit. Two different procedures were investigated to form the endothelialized ACV units: (i) direct cell seeding of acellular channels and (ii) endothelial cell ingrowth after photoablation (figs. S2 and S3). In the first approach, the acellular ACV unit is first fabricated by photoablation, followed by seeding cells into the fully acellular device through the inlets of the two main parallel channels with 10-l perfusions of HUVECs (Lonza, passages 3 to 7, with EBM basal medium supplemented with EGM endothelial cell growth medium) at a density of 8 106 cells/ml. Once the cells were attached, the devices were cultured under gravity-driven flow across the capillaries between the two main channels for 7 days. To create a gravity-driven flow, 200 and 180 l of culture media was placed in the two main channel inlets to set the initial pressure drop at approximately 1 cmH2O, leading to a peak velocity of approximately 1 mm/s across the ACV unit between the two main channels. The pressure drop was reset every 12 hours to maintain flow in the capillary regions. In the second approach, the two main microchannels were first seeded with 10-l perfusions of HUVECs at a density of 8 106 cells/ml and cultured for 3 days to form robust endothelialized lumens. Multiphoton photoablation was then performed to create microchannel void spaces that tapered down to 5 m in diameter within the collagen scaffold between the lumenal wall of the two main vessels and ablate endothelial cells at the two end connections. Cellular and collagen ablation was confirmed by imaging identical areas after ablation using transmitted light and by second-harmonic generation imaging. The ablated vessels were then cultured for an additional 4 days to allow for endothelial cell ingrowth. The culture was maintained at the same pressure drop as the first approach and replenished twice a day with fresh culture media. P. falciparum parasite lines were cultured using anonymized human O+ type RBCs (Valley Biomedical) in RPMI 1640 (Gibco) supplemented with 10% human type A+ serum in a gas mixture of 90% N2, 5% CO2, and 5% O2. The knobless parasite line 2G2 was previously derived by lack of gelatin floatation followed by limited dilution cloning (40), while the IT4VAR19 line was generated after repeatedly panning on transformed human brain microvascular endothelial cells followed by limited clonal dilution (59, 60). Mature-stage IRBCs were enriched to 60 to 90% parasitemia by magnetic separation (MACS Cell Separator, LD Columns, Miltenyi Biotec) before perfusion for single-cell and population dynamics experiments. Both parasite lines predominantly express a single var gene and were derived from the IT4/FCR3 parasite genotype. Magnetic enriched mature-stage P. falciparumIRBCs or packed RBCs were resuspended in 10% fetal bovine serum (FBS)containing EGM at 5 106 cells/ml, allowing the visualization of individual cells as they traverse the ACV devices. The dilute cell suspension was placed in the inlet and outlet of one microchannel at a maximum initial pressure drop of approximately 1 cmH2O, creating a hydraulic gradient between the two microchannels and establishing gravity-driven flow across the capillaries. The peak velocity of the RBCs across the center capillary zone was approximately 1 mm/s. In single-cell dynamics studies, the pressure drop and resulting velocity rate were maintained and slightly adjusted over the course of the assay by removing or adding a small volume (~5 l) of cell suspension from the inlet to maintain the RBC velocity in this range and allow for video capture of single-cell dynamics. The motion of individual RBCs within one of the capillary constriction channels was visualized with a Nikon TiE inverted widefield microscope, and videos were acquired at 20 and 250 to 500 frames/s using an Orca-Flash4.0V2 Digital CMOS camera (Hamamatsu). After acquisition, videos were analyzed using custom MATLAB scripts. For experiments with 2G2, videos were previously inspected, and only IRBCs with hemozoin were used in the downstream analysis. Briefly, individual frames containing RBCs were smoothed using a Wiener filter, inverted, then background subtracted using a mean filter. RBCs were detected by applying a Canny edge detection operator. Small gaps in RBC outlines were closed automatically using an edge-linking algorithm or manually (fig. S5). Individual RBC outlines were linked into trajectories based on displacement between outlines in different frames. Out-of-focus and overlapping RBCs were excluded from the analysis. Biological replicates were taken in at least two different days. Magnetic enriched mature-stage P. falciparumIRBCs or packed RBCs were fluorescently labeled according to the PKH26 Red Fluorescent Cell Linker Kit (Sigma-Aldrich). To simulate blood with physiological parasitemia, labeled cells (normal RBCs or IRBCs) were added to unlabeled normal RBCs at a final parasitemia of 0.4 to 4% (iRBC/total RBC) and then diluted to 40% hematocrit in EGM (containing 5% FBS). RBCs were encouraged to flow across the device driven by a pressure drop of approximately 1 cmH2O for 20 min, leading to a peak velocity of approximately 1 mm/s, mimicking measured physiological velocities within the capillaries (34). The perfusion of RBCs was monitored and imaged at different fields of view (three capillary channels in each field of view) and continuous time frames. At the beginning of the perfusion, devices were quickly scanned to identify perfusable channels. Videos were taken for 10 s for each perfusable channel in the same order at each time point to determine the location and extent of binding after 1, 4, 7, and 20 min of perfusion. Each condition was repeated in independent days. Population dynamics analysis. Quantification of population dynamics was performed on fluorescent images taken after 20 min of perfusion. Images were normalized between average background values and peak fluorescent intensity values, and a two-pixel radius median filter was used to remove speckle noise using MATLAB. Masks were manually drawn to outline individual capillary constriction channels using ImageJ. Average fluorescent intensity was calculated at each x position as the sum of intensity values across the y dimension divided by the diameter of the vessel at this position. The central point of each capillary region was determined, and the average intensity maps were lined up across all images at this central point. IT4VAR19 trophozoite-stage enriched IRBCs were treated with a trypsin (66.67 g/ml; Sigma-Aldrich) solution in 1 phosphate-buffered saline for 30 min at 37C, followed by an inhibition with an equal volume of FBS before perfusion of capillary devices. To determine PfEMP1 surface expression after trypsinization, an IT4VAR19 culture was incubated for 30 min at 37C with a trypsin solution (10 g/ml). Surface PfEMP1 was recognized with rat polyclonal antibodies against IT4VAR19 DBL2 and DBL6 (1:10) for 30 min at 4C, followed by an incubation with goat anti-rat immunoglobulin GAlexa Fluor 488 (1:400, Molecular Probes) for 30 min. Infected erythrocytes (parasite nuclei) were detected with ethidium bromide (2 g/ml; Invitrogen). Stained cells were washed in phosphate-buffered saline and analyzed on an LSRII fluorescence-activated cell sorter machine (BD Biosciences). Analysis was performed using FlowJo 10 (Tree Star Inc., Ashland, OR). All results are presented as means SE and assumed to be distributed approximately normally. The sample number represents the number of microvessel devices (ACV units) fabricated and analyzed unless otherwise noted. Single variable analysis with two-tailed t test assuming unequal variance was used to determine statistical significance between two samples for analysis of perfusability and endothelialization efficiencies. Two-way analysis of variance (ANOVA) was used to determine significance in population dynamics data, followed by Dunnetts multiple comparisons test. Supplementary material for this article is available at http://advances.sciencemag.org/cgi/content/full/6/3/eaay7243/DC1 Supplementary Materials and Methods Fig. S1. Photoablation-guided fabrication of acellular capillary-sized microchannels. Fig. S2. Cellular limitations of capillary fabrication. Fig. S3. Endothelialization strategies for capillary network. Fig. S4. Ultrastructural analysis of vessels at capillary regions across the ACV units imaged via TEM. Fig. S5. Edge detection workflow for studying traversal of single RBCs through a capillary-sized constriction. Fig. S6. Transcriptional profiling of var gene expression in the two parasite lines. Fig. S7. Ultrastructural analysis of capillary region after perfusion of RBCs imaged via TEM. Fig. S8. Trypsin cleaves the surface-expressed IT4VAR19 PfEMP1 variant. Movie S1. Endothelial ingrowth into 20-m capillaries between two large vessels after photoablation. Movie S2. Representative video of normal RBCs perfused through endothelialized capillaries at physiological hematocrit. Movie S3. Representative video of normal RBCs perfused through acellular collagen capillary-shaped channels at physiological hematocrit accumulating a significant amount before entering the capillary region and jetting and leading to significantly lower hematocrit into the downstream. Movie S4. Representative video of normal RBCs stretching through capillaries (diameter, ~10 m) when perfused at the single-cell scale. Movie S5. Representative video of normal RBCs tumbling through capillaries (diameter, ~10 m) when perfused at the single-cell scale. Movie S6. Representative video of 2G2 IRBCs tumbling through capillaries (diameter, ~10 m) when perfused at the single-cell scale. Movie S7. Representative video of normal RBCs perfused through the capillaries at physiological hematocrit with no cell accumulation in the lumen. Movie S8. Representative video of IT4VAR19 IRBCs perfused through the capillaries at physiological hematocrit accumulating a significant amount and blocking the capillary flow. Movie S9. Representative video of trypsinized IT4VAR19 perfused through the capillaries showing a significant decrease in cell accumulation and not blocking the capillary flow. Movie S10. Representative video of 2G2 IRBCs perfused through the capillaries at physiological hematocrit accumulating at postcapillary regions but not blocking the capillary flow. References (61, 62) This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. Acknowledgments: We acknowledge the Lynn and Mike Garvey Imaging Laboratory in the Institute of Stem Cell and Regenerative Medicine, the Nanotech User Facility, and the Flow Cytometry Facility, all at the University of Washington, and the Electron Microscope Facility in the Fred Hutchinson Cancer Research Institute. We thank R. Nagao for the helpful discussion and N. Sniadecki for sharing his microscope. We acknowledge the imaging and flow cytometry facility at the Seattle Childrens Research Institute. Funding: This work is supported by the NIH R01 HL130488 (to J.D.S. and Y.Z.), R01HL141570, UG3TR002158, and UH2/UH3 DK107343 (to Y.Z.), and 2T32EB001650 and F30HL134298 (to C.A.); the NSF 1652141 and 1807398 (to C.A.D.); and the AHA postdoctoral fellowship (to M.B.). Author contributions: Y.Z. conceived the project. Y.Z., J.D.S., and C.A.D. supervised the project. C.A., C.G., C.H., M.B., J.D.S., and Y.Z. designed the experiments. C.A., C.G., C.H., and M.B. performed the experiments and data analysis with the assistance of K.P. and E.Y. All authors interpreted the data. C.A., C.G., J.D.S., and Y.Z. wrote the manuscript. All authors edited and approved the manuscript. Competing interests: The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in this paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the corresponding author (yingzy{at}uw.edu). Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries - Science Advances Complete Overview of Cancer Nanomedicine Market to Witness High Rate of Growth in Forthcoming Years – Fusion Science Academy § January 17th, 2020 § Filed under Nano Medicine Comments Off on Complete Overview of Cancer Nanomedicine Market to Witness High Rate of Growth in Forthcoming Years – Fusion Science Academy In 2018, the market size of Cable Cars & Ropeways Market is million US$ and it will reach million US$ in 2025, growing at a CAGR of from 2018; while in China, the market size is valued at xx million US$ and will increase to xx million US$ in 2025, with a CAGR of xx% during forecast period. In this report, 2018 has been considered as the base year and 2018 to 2025 as the forecast period to estimate the market size for Cable Cars & Ropeways . This report studies the global market size of Cable Cars & Ropeways , especially focuses on the key regions like United States, European Union, China, and other regions (Japan, Korea, India and Southeast Asia). Request Sample Report @https://www.mrrse.com/sample/9222?source=atm This study presents the Cable Cars & Ropeways Market production, revenue, market share and growth rate for each key company, and also covers the breakdown data (production, consumption, revenue and market share) by regions, type and applications. Cable Cars & Ropeways history breakdown data from 2014 to 2018, and forecast to 2025. In global Cable Cars & Ropeways market, the following companies are covered: market taxonomy and product definitions for the global cable cars & ropeways market assessment. In the next section, the report describes the market development background and covers macro-economic factors, industry factors, forecast factors, regional weighted average pricing analysis, value chain overview covering approximate margins, an indicative list of stakeholders involved in each stage and an assessment of the cable cars & ropeways market for the base year considered for the study. The next section of the report discusses market dynamics, such as drivers, restraints and trends, impacting the market growth at a global level. Market opportunities for manufacturers have been presented in the subsequent section of the same chapter. This section also includes the impact assessment of market dynamics on the global cable cars & ropeways market at a qualitative level, based on analysis facts and insights. Subsequent sections of the report provide value (US$ Mn) and volume (Unit Systems) projections for the cable cars & ropeways market on the basis of the aforementioned segments at a global level. The global market values represented in these sections have been agglomerated by collecting data and information at a regional level. The market information, along with key facts and insights, covers unique analysis frameworks, such as absolute $ opportunity analysis, year-on-year growth trend comparison, market share and attractiveness analysis, for each of the sub-types covered in each segment. The next section of the report presents a summarised view of the global cable cars & ropeways market, based on six prominent regions considered in the study. The section includes the regional market position, growth potential, trends, market attractiveness analysis and key insights pertaining to each of these regions. The market analysis sections cover Y-o-Y growth trends, market share analysis, market attractiveness and incremental $ opportunity assessment for each of the aforementioned segments. These sections analyse the degree to which the global drivers are influencing this market in each region. All the above sections evaluate the present market scenario and growth prospects in the global cable cars & ropeways market while the forecast presented in the sections assess the market size in terms of volume and value. In order to offer an accurate forecast, we started by sizing the current market, which forms the basis of how the global cable cars & ropeways market is expected to develop in the future. Given the characteristics of the market, we triangulated the outcome of three different types of analysis, based on primary research, secondary research and our own analysis. However, forecasting the market in terms of various cable cars & ropeways segments and regions is more a matter of quantifying expectations and identifying opportunities rather than rationalising them after the completion of the forecast exercise. In addition, it is imperative to note that in an ever-fluctuating global economy, we not only conduct forecast in terms of CAGR, but also analyse the market on the basis of key parameters, such as Year-on-Year (Y-o-Y) growth, to understand the predictability of the cable cars & ropeways market and identify the right opportunities available. As previously highlighted, the cable cars & ropeways market is split into a number of sub-segments. All the cable cars & ropeways sub-segments, in terms of product type, end use and region, have been analysed on the basis of Basis Point Share (BPS) to understand each individual segments relative contribution to the market growth. This detailed level of information is important for the identification of various key trends being witnessed in the cable cars & ropeways market. Another key feature of this report is the analysis of all the key segments in the cable cars & ropeways market, sub-segments and the regional adoption and revenue forecast in terms of absolute dollar opportunity. This is traditionally overlooked while forecasting the market; however, the absolute dollar opportunity is critical in assessing the level of opportunity that a provider can look to achieve as well as to identify potential resources from a sales and delivery perspective in the cable cars & ropeways market. In order to understand the key market segments in terms of the growth and consumption of cable cars & ropeways across concerned regions, PMR has developed the attractiveness index, which will help providers to identify real market opportunities. In the final section of the report, a competitive landscape of the cable cars & ropeways market has been included to provide report audiences with a dashboard view, categorised on the basis of providers present in the value chain, their presence in the cable cars & ropeways market and key differentiating factors and strategies. The primary category of providers covered in the report is cable cars & ropeways manufacturers. This section is primarily designed to provide clients with an objective and detailed comparative assessment of the key providers specific to a market segment in the value chain of the cable cars & ropeways market. Report audiences can gain segment-specific vendor insights to identify and evaluate key competitors on the basis of in-depth assessment of their capabilities and success in the cable cars & ropeways marketplace. Detailed profiles of providers have also been included under the scope of the report to evaluate their long- and short-term strategies, key offerings and recent developments pertaining to the cable cars & ropeways market. Examples of some of the key competitors covered in this report include Doppelmayr/Garaventa Group, Leitner Group, Leitner-Poma of America, Inc, MND Group, Bartholet Maschinenbau AG (BMF), Nippon Cable Co., Ltd., CONVEYOR & ROPEWAY SERVICES PVT. LTD., Damodar Ropeways & Infra Ltd., STM TELEFERIK and CCM FINOTELLO SRL, among others. Request For Discount On This Report @ https://www.mrrse.com/checkdiscount/9222?source=atm Chapter 1, to describe Cable Cars & Ropeways product scope, market overview, market opportunities, market driving force and market risks. Chapter 2, to profile the top manufacturers of Cable Cars & Ropeways , with price, sales, revenue and global market share of Cable Cars & Ropeways in 2017 and 2018. Chapter 3, the Cable Cars & Ropeways competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast. Chapter 4, the Cable Cars & Ropeways breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2014 to 2018. Buy This Report @ https://www.mrrse.com/checkout/9222?source=atm Chapter 12, Cable Cars & Ropeways market forecast, by regions, type and application, with sales and revenue, from 2018 to 2024. Chapter 13, 14 and 15, to describe Cable Cars & Ropeways sales channel, distributors, customers, research findings and conclusion, appendix and data source. We are a vibrant market research company which is focused on catering to more and more people day by day. Our research company is one of a few reliable market research report companies in todays date. Complete Overview of Cancer Nanomedicine Market to Witness High Rate of Growth in Forthcoming Years - Fusion Science Academy Is Spago Nanomedical (NGM:SPAG) In A Good Position To Invest In Growth? – Simply Wall St § January 17th, 2020 § Filed under Nano Medicine Comments Off on Is Spago Nanomedical (NGM:SPAG) In A Good Position To Invest In Growth? – Simply Wall St We can readily understand why investors are attracted to unprofitable companies. For example, biotech and mining exploration companies often lose money for years before finding success with a new treatment or mineral discovery. But the harsh reality is that very many loss making companies burn through all their cash and go bankrupt. Given this risk, we thought wed take a look at whether Spago Nanomedical (NGM:SPAG) shareholders should be worried about its cash burn. In this report, we will consider the companys annual negative free cash flow, henceforth referring to it as the cash burn. Well start by comparing its cash burn with its cash reserves in order to calculate its cash runway. Check out our latest analysis for Spago Nanomedical You can calculate a companys cash runway by dividing the amount of cash it has by the rate at which it is spending that cash. In September 2019, Spago Nanomedical had kr23m in cash, and was debt-free. In the last year, its cash burn was kr45m. That means it had a cash runway of around 6 months as of September 2019. To be frank, this kind of short runway puts us on edge, as it indicates the company must reduce its cash burn significantly, or else raise cash imminently. Importantly, if we extrapolate recent cash burn trends, the cash runway would be noticeably longer. The image below shows how its cash balance has been changing over the last few years. Notably, Spago Nanomedical actually ramped up its cash burn very hard and fast in the last year, by 135%, signifying heavy investment in the business. As if thats not bad enough, the operating revenue also dropped by 16%, making us very wary indeed. Considering these two factors together makes us nervous about the direction the company seems to be heading. While the past is always worth studying, it is the future that matters most of all. For that reason, it makes a lot of sense to take a look at our analyst forecasts for the company. Since Spago Nanomedicals revenue is down, and its cash burn is up, shareholders would quite reasonably be considering whether it can raise more money easily, if need be. Generally speaking, a listed business can raise new cash through issuing shares or taking on debt. Commonly, a business will sell new shares in itself to raise cash to drive growth. By looking at a companys cash burn relative to its market capitalisation, we gain insight on how much shareholders would be diluted if the company needed to raise enough cash to cover another years cash burn. Spago Nanomedicals cash burn of kr45m is about 13% of its kr336m market capitalisation. As a result, wed venture that the company could raise more cash for growth without much trouble, albeit at the cost of some dilution. Even though its increasing cash burn makes us a little nervous, we are compelled to mention that we thought Spago Nanomedicals cash burn relative to its market cap was relatively promising. After looking at that range of measures, we think shareholders should be extremely attentive to how the company is using its cash, as the cash burn makes us uncomfortable. For us, its always important to consider risks around cash burn rates. But investors should look at a whole range of factors when researching a new stock. For example, it could be interesting to see how much the Spago Nanomedical CEO receives in total remuneration. If you would prefer to check out another company with better fundamentals, then do not miss this free list of interesting companies, that have HIGH return on equity and low debt or this list of stocks which are all forecast to grow. Is Spago Nanomedical (NGM:SPAG) In A Good Position To Invest In Growth? - Simply Wall St How the Internet of Medical Things Is Impacting Healthcare – HealthTech Magazine § January 17th, 2020 § Filed under Nano Medicine Comments Off on How the Internet of Medical Things Is Impacting Healthcare – HealthTech Magazine What Is IoMT? The IoMT is a connected infrastructure of medical devices, software applications, and health systems and services. And while a growing pool and general adoption of IoT technologies are benefiting many industries, its a wave of sensor-based tools including wearables and stand-alone devices for remote patient monitoring and the marriage of internet-connected medical devices with patient information that ultimately set the IoMT ecosystem apart. The rise of IoMT is driven by an increase in the number of connected medical devices that are able to generate, collect, analyze or transmit health data or images and connect to healthcare provider networks, transmitting data to either a cloud repository or internal servers, the Deloitte report notes. Ultimately, this connectivity between medical devices and sensors is streamlining clinical workflow management and leading to an overall improvement in patient care, both inside care facility walls and in remote locations. The capabilities of IoMT are more accurate diagnoses, fewer mistakes and lower costs of care. Paired with smartphone applications, the technology allows patients to send their health information to doctors in order to better surveil diseases and track and prevent chronic illnesses. In fact, a study conducted by researchers from Cedars-Sinai Medical Center and UCLA demonstrates the ability of Fitbit activity trackers to more accurately evaluate patients with ischemic heart disease by recording their heart rate and accelerometer data simultaneously. That helps explain why mHealthIntelligence reports that 88 percent of care providers are investing in remote patient monitoring solutions. This type of technology is not only helping to improve the patient experience by eliminating the need for in-person medical visits, but its also helping to reduce costs. Goldman Sachs estimates that IoMT will save the healthcare industry $300 billion annually in expenditures primarily through remote patient monitoring and improved medication adherence. That said, another positive effect of IoMT is on drug management via the introduction of smart pills that contain microscopic sensors, which, once swallowed, can transmit data to connected devices. Some digital medicine companies, such as Proteus Discover, have focused their smart pill capabilities on measuring medication treatment effectiveness to improve clinical outcomes. Others, such as HQs CorTemp, are using the pills to monitor patients internal health, wirelessly transmitting data such core temperature measurements that can be critical in life or death situations. READ MORE: Discover how IoMT will evolve to better fit healthcare needs in 2020. The global IoMT market was valued at $44.5 billion in 2018 and is expected to grow to $254.2 billion in 2026, according to AllTheResearch. The smart wearable device segment of IoMT, inclusive of smartwatches and sensor-laden smart shirts, made up for the largest share of the global market in 2018, at roughly 27 percent, the report finds. This area of IoMT is poised for even further growth as artificial intelligence is integrated into connected devices and can prove capable of the real-time, remote measurement and analysis of patient data. The IoMT ecosystem expansion is paving the way for other new technologies too, such as kiosks that provide connectivity to care providers. These kiosks will further enable clinicians to monitor and treat patients remotely an ever-growing need for patients in rural communities as they struggle to recruit and retain medical specialists. Regardless of a patients location or condition, an evolution of the IoMT ecosystem will become increasingly impactful. And even the most remote locations will benefit from better access to care as connected medical devices continue to find their way into the hands of both patients and clinicians. How the Internet of Medical Things Is Impacting Healthcare - HealthTech Magazine Flu outbreak worse in Texas than nationally – Runnels County Register § January 16th, 2020 § Filed under Nano Medicine Comments Off on Flu outbreak worse in Texas than nationally – Runnels County Register The flu is bad in 2019 and 2020. Influenza (flu) is a highly contagious seasonal viral illness that is of two types, A and B, with hundreds of different sub-types. It is spread by microscopic droplets that are formed with each cough or sneeze. Droplets can enter the body directly through the mouth or nose, or indirectly when they dry and fall to a surface where hands then carry infectious material into the mouth, eyes or nose. The illness causes fever as well as headache, body aches and sometimes eye, throat or GI symptoms. It can lead to bacterial infections of the ears and also to pneumonia. It is this last complication that is responsible for most of the deaths due to flu, and these are most common in the very young or very old, or those with underlying diseases such as asthma, COPD, cancer or diabetes. The CDC estimates that flu has resulted in between 9 million 45 million illnesses, resulting in 140,000 810,000 hospitalizations and between 12,000 61,000 deaths annually since 2010. This year is worse than last year at this time and its worse in Texas than it is nationally. Of course, the best thing is to avoid getting it, and vaccination is the best way to do that. The vaccine has proven to have a relatively good match this year, especially for Type B which is the Type on the rise and likely to account for most of the cases going forward. If you have not had the vaccine it is recommended that you get it. Next most valuable is to stay away from people who are infectious. After exposure there is a 1 to 4 day interval before the onset of symptoms (average is 2 days). The infected individuals begin viral shedding (transmitting the infection) in 12 to 48 hours after exposure, and that is 12 to 48 hours prior to the time they begin to feel sick. They continue to be infectious for 4 to 10 days, and sometimes longer (especially in older individuals). It is also known that some people have a partial response to vaccination, resulting in them having infections in which they may transmit the disease, but have few or no symptoms. This means that staying away from people who are sick is helpful, but by itself it is an insufficient strategy. There are prescription medications that can be used prophylactically to reduce the chance of infection, and these should be considered for people at high risk who have known opportunity for exposure. If you suspect that you have the flu, and you are at high risk for complications, you should be seen by a healthcare provider as soon as you have symptoms. There are medications to treat the flu, and they all work better if they are started earlier. Usually they are not considered worthwhile if not started within 48 hours after symptoms are first noted. Not everyone who has the flu needs to be seen by a healthcare provider, and not all those who are seen need medication. The costs and side effects of these medications are sometimes quite significant, and you should weigh these against expected benefits. (Typically symptoms last about a day less with treatment.) If you or your child are otherwise healthy and between the ages of 2 and 65 years old, symptomatic treatment is usually sufficient if there is no trouble breathing and fever can be controlled with acetaminophen in recommended doses. Symptomatic treatment consists of controlling the fever, rest and plenty of fluids (about 2 -3 quarts/d for adults with fever). Normally symptoms resolve over about a week, and the individual can return to work or school after 24 hours without fever AND without medication that would prevent fever, such as acetaminophen. This article is intended to provide general information only, and is not to be taken as medical advice. For advice about a particular case or situation, consult your own physician or other trusted health professional. Bradly Bundrant, MD, MPH Medicine, Science and Culture is a service of The Health and Wellness Coalition of Runnels County. Our next meeting will be January 16, 2020 at 7:30 pm at the North Runnel Clinic in Winters. Flu outbreak worse in Texas than nationally - Runnels County Register Immunotherapy Leads to Potentially Durable Response in Patients with Multiple Myeloma – Pharmacy Times § January 16th, 2020 § Filed under Nano Medicine Comments Off on Immunotherapy Leads to Potentially Durable Response in Patients with Multiple Myeloma – Pharmacy Times Immunotherapy Leads to Potentially Durable Response in Patients with Multiple Myeloma The multi-center, international DREAMM-2 trial evaluated belantamab mafodotin and found that almost one-third of patients whose disease had returned after other therapies achieved a partial response or better when treated with this therapy. Multiple myeloma is a cancer of the plasma cells, which build up in bone marrow and crowd out healthy blood cells. Patients enrolled in the trial were required to have the disease that had relapsed or was refractory to a proteasome inhibitor, immunomodulatory drug, and anti-CD38 antibody. The phase 2 trial involved 58 centers in 8 countries. Between June 2018 and January 2019, 196 patients were treated with either a low dose or high dose of the drug. In the low dose treatment group, 31% of patients achieved an overall response. Of that group, 60% had a very good partial response or better. In the high dose group, 34% achieved an overall response, with 59% of those patients achieving a very good partial response or better. Responses were achieved quickly, after a median of 1.4 months of treatment. The median progression-free survival was 2.9 months and 4.9 months, respectively, although it was not reached in patients who responded. These data build off the phase 1 trial that showed patient responses improved over time and contributed to prolonged progression free survival. Since this study did not reach the median duration of response, we anticipate that further follow-up on these patients will confirm these responses can be durable, said Adam D. Cohen, MD, senior author and assistant professor of Hematology-Oncology in the Perelman School of Medicine at the University of Pennsylvania in a press release. The most common adverse events (AEs) included nausea, fatigue, blurred vision, and dry eye. The majority of AEs were mild to moderate in severity. Microscopic changes to the lining of the cornea were noted through eye examination in 71% of low dose and 75% of high dose patients. Other AEs included thrombocytopenia, which was reported in 35% of low dose patients and 59% of high dose patients. BCMA is a receptor on the surface of multiple myeloma cells that helps the cells grow and survive. Belantamab mafodotin is an experimental antibody-drug conjugate that consists of an antibody to target BCMA that is linked to a potent chemotherapy drug called MMAF. After binding to BCMA, belantamab mafadotin is internalized into the melanoma cell and then releases the MMAF, leading to highly targeted killing of the myeloma within the bone marrow while limiting systemic chemotherapy adverse events. Belantamab mafadotin can also attract surrounding immune cells to attack the myeloma cells through a mechanism called antibody-dependent cellular cytotoxicity. Data from the DREAMM-2 study have been submitted to the FDA for consideration for approval. ReferenceBCMA-Targeted Immunotherapy Can Lead to Durable Responses in Multiple Myeloma [press release] Penn Medicine News website. Published December 17, 2019. https://www.pennmedicine.org/news/news-releases/2019/december/bcma-targeted-immunotherapy-can-lead-to-durable-responses-in-multiple-myeloma. Accessed January 13, 2020. Immunotherapy Leads to Potentially Durable Response in Patients with Multiple Myeloma - Pharmacy Times School of Medicines Begins Study on New Phage Therapy – Times Tech Pharma § January 16th, 2020 § Filed under Nano Medicine Comments Off on School of Medicines Begins Study on New Phage Therapy – Times Tech Pharma In an ongoing UC San Diego School of Medicine study, successful mice trials for another treatment show promising outcomes on the utilization of phage treatment to target alcoholic liver malady. These trials are being conducted since Spring 2017. Bacteriophages, or phages, are normally present infections that contaminate and eat microscopic organisms. In contrast to anti-toxins, which additionally crush microscopic organisms in a murder them-all way, phages focus on a specific sort of microorganisms strain with negligible reactions. Since phages live on microscopic organisms, the phage corrupts when the host microbes kicks the bucket. Because of the high explicitness of the objective microorganisms, phage treatment is as yet a constrained application practically speaking, which makes it a field of monstrous investigation for analysts. At present, the most ordinarily utilized medications for alcoholic liver malady incorporate liver transplantation and corticosteroids, a hormone used to lessen liver aggravation. In any case, liver transplantation is definitely not a promptly accessible choice as the national shortlist for a sound liver is around 14,000 individuals in length, and medical procedures are offered at a chosen few medicinal focuses. Moreover, corticosteroid treatment isnt an ensured arrangement as the impacts of the treatment change among various people. Liver harm collects over long stretches of liquor addiction. When extreme indications start to appear, up to 90 percent of patients bite the dust inside 90 days of an analysis of serious alcoholic liver illness, known as alcoholic hepatitis. With an attention on the connection between liver infection and intestinal microorganisms, the Dr. Bernd Schnabl Lab at UCSD has distinguished and corresponded bacterial contamination with liver infection in their past investigation. Yi Duan, a postdoctoral understudy in Schnabls lab gathering and the main creator of the examination paper, addressed the UCSD Guardian about the connection betweens liver harm and phage treatment. In both the human contextual analyses and the mice tries, the gathering found that the translocation of the gut microscopic organisms, Enterococcus Faecalis, can cause bacterial contamination in the liver. Also, proton-siphon inhibitors or PPIs, an ordinarily utilized medication to diminish gastric corrosive emission and indigestion for patients with constant liver sickness because of liquor abuse, make a positive criticism circle in patients which declines the condition. Consultant respiratory physician at DescriptionThe Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania, Philadelphia, PA 19104, United States. Mail Me : Chrissokol@timestechpharma.com School of Medicines Begins Study on New Phage Therapy - Times Tech Pharma Future Of Nano Medicine	cc/2020-05/en_middle_0111.json.gz/line2860
__label__cc	0.630293	0.369707	Dies Irae: Song To The Witch Fujii Sanda,Masada Takashi Latest Chapter : Dies Irae: Song To The Witch Chapter 8 The 1962 Cuban Missile Crisis was a declaration of war on the Longinus Dreizehn Orden! The Longinus Dreizehn Orden stood in the way of the allied forces during World War II and left them with a sense of defeat, after which they disappeared without a trace… But a certain man’s testimony revealed the existence of this group to the world. The major powers of the world, considering them a serious threat, awaken a witch. One created in secrecy. In the spotlight, the Longinus Dreizehn Orden’s own witch, Rusalka Schwägelin, enters the stage. The battle between witches hurls the stage that is America into a chaotic tempest that defies human knowledge. The truth about the 1962 Cuban Missile Crisis is revealed at last! Read “ Dies Irae: Song To The Witch ” Dies Irae: Song To The Witch Chapter 0 Stay informed of NEWEST chapters of Dies Irae: Song To The Witch with notification directly sent to your email.	cc/2020-05/en_middle_0111.json.gz/line2868
__label__cc	0.586695	0.413305	Blog Post Michael Jamison Oct 30, 2015 Parks in Peril: Saving What’s Sacred in the “Backbone of the World” A development threat to the wild lands surrounding Glacier National Park is more than just a danger to the environment. It is an attack on a place of irreplaceable cultural significance. The Badger-Two Medicine region borders Glacier National Park to the southeast. Oilmen have eyed this wild land for decades, and NPCA has joined the Blackfeet Nation in calling for permanent protections. camera icon Stephen Legault Fifteen years ago, while lightning crackled through sheets of rain, my son was born in the loft of a log cabin on the wild western fringe of Glacier National Park. Too Sacred to Drill “Badger-Two Medicine is too sacred to develop. We’re grateful this administration has taken a critical step toward permanent protection of this site that is like a church — a divine sanctuary — to our people.” Harry Barnes, Chairman of the Blackfeet Nation Tribal Council A decade later, in the clear crisp of autumn, we took up shovels to fulfill the last wishes of a dear friend, laying her to rest in those same untamed borderlands just beyond the park’s boundary. In between were the weddings and anniversaries, reunions and holidays. A grizzly in the woodshed on Halloween night. The howl of wolves. Elk in the garden. Alpenglow painting peaks beyond the kitchen window. I’ve been walking those boundary mountains again this fall, hauling in firewood and gathering mushrooms while the dog flushes grouse from trail’s edge. And after 30 years of this seasonal cycle, I’ve started wondering just what it is that makes this place so special. For me, of course, there’s the weight of years, the accumulation of moments, the slow-growing roots that make a house a home. We all have those special places—private sanctuaries made pure by the living of life. And so I have protected my special place fiercely, from a seemingly ceaseless parade of greed that would pave it, mine it, log it, and develop it, from people who believe cell phone towers and power lines are “improvements.” As if this perfection of wild nature could be improved on. Gift for Wild Lands: Interior Retires Remaining Oil and Gas Leases Near Glacier National Park The U.S. Department of Interior protected Montana’s natural and cultural heritage by negotiating the removal of all remaining oil and gas leases in the Badger-Two Medicine roadless area, adjacent to… I have only known this western margin of Glacier National Park for 30 years, didn’t find it until I was 20, so this is not my people’s home. Despite my deep connection to here, I have no generations weighing on me. So imagine how relentlessly I might fight to protect a place if, instead of 30 years, I had experienced untold millennia of connection to the land—not an individual’s roots, but an entire culture’s foundation. Over on Glacier’s eastern margins, the sacred runs far deeper and is marked by the milestones not of a single lifetime but of an entire society. There, in a place known as the Badger-Two Medicine, are the cultural headwaters of the Blackfeet Nation. The 160,000-acre region is named for the two rivers flowing cold and clear from its mountain heights. Surrounded by Glacier National Park, the Bob Marshall Wilderness, and the Blackfeet Indian Reservation, it is a wildland corridor linking ancient migration routes along the spine of Montana’s Rocky Mountains, with room to roam for bears and bison, wolves and wolverines. This is Glacier’s wild back porch, and an irrevocable stronghold of Blackfeet religion. It is a world-class natural and cultural heritage without equal, known to the Blackfeet as the “Backbone of the World.” It is the source of their origin stories, a land marking boundless births and battles and burial grounds, the place they were given the holy Sun Dance. This is, quite literally, sacred ground. It is also, unfortunately, the place where industry would like to drill for oil and gas, and has recently sued for the right to do so. I traveled with Blackfeet elders last winter to Washington, D.C., to explain why this park borderland is so special, and why the many millennia of experiences that link people to place should matter. White House officials met with us in what had once been a president’s bedroom, beneath an elegant chandelier. They explained the rich history of the room and told us it was a profound part of “America’s sacred history.” My Blackfeet friend replied, “I understand. It’s not a good place for an oil well.” Glacier National Park preserves more than a million acres of forests, alpine meadows and lakes with habitat for a wide variety of plant and animal life. Oil and gas leasing is no longer allowed in the Badger-Two Medicine. Nor are roads or dirt bikes or snowmobiles. The entire region has been designated a Traditional Cultural District under the National Historic Preservation Act. And many, many companies have voluntarily relinquished their old leases, declaring the Badger-Two Medicine too extraordinary to drill. Even today, a handful of companies persist, refusing offers to buy their historic holdings or swap them for leases in other, less sensitive areas. The Blackfeet, in turn, have declined to transform the center of their spiritual universe into an industrial zone. It is just too special. If we cannot protect this tremendous untamed habitat—this profound and sacred space connecting its inhabitants with centuries of ancestors—then what place can we protect? Where can we possibly hope to make a stand? I took my job with the National Parks Conservation Association in part because I needed the tremendous strength and wisdom of the organization to help protect my own backyard. And we have done that—we have protected Glacier Park’s western wild lands. Now, it is time to do the same on its eastern front. And so I have left my fall foraging to join the Blackfeet, asking federal land managers to cancel all remaining Badger-Two Medicine leases. My NPCA colleagues have made similar requests, in similarly important landscapes, all across our continent. They are pushing back against oil wells abutting Arches National Park, high voltage power lines arcing over the historic landscape of Jamestown, and a mega-mall—yes, a mega-mall—at the Grand Canyon’s southern gateway. 9 National #ParksInPeril From Arches to Yellowstone, the crown jewels of our National Park System are at a crossroads. And it is up to each of us to determine which path they take.… We all have our own special places and, like the Blackfeet, we also have shared cultural places. We don’t call them sacred lands. Instead, we call them national parks. Arches, Colonial National Historical Park, Grand Canyon. Wells, power lines, malls. Similar avarice threatens Mojave, Yosemite, and Grand Teton. It endangers the coral reefs of Biscayne and the bison of Yellowstone. Each of these parks—on NPCA’s list of Parks in Peril—is a place that has proved the power to shape us, rather than be shaped by us, and that, finally, is what makes an special place exceptional enough to protect. America’s parks are about as close as nature gets to the sacred. And it is our collective relationship with these places—the countless intimate and individual experiences that intersect and merge to forge powerful cultural connections—that must move us to act on their behalf. The perils are too great, and these places are too worthy—too special to all of us—to lose. Michael Jamison Crown of the Continent Senior Program Manager, Northern Rockies Michael joined NPCA’s Glacier Field Office in September 2010. As Senior Program Manager for NPCA’s Crown of the Continent initiative, Michael continues to expand his efforts to promote the narrative of the Crown and of the people who call it home Read more by Michael Jamison Responsible Energy Preserving History & Culture	cc/2020-05/en_middle_0111.json.gz/line2869
__label__cc	0.641393	0.358607	More World Stories» Report: Russian Spies Posed as Plumbers in Davos Greta's Davos Warning: 8 Years to Save the Planet KFC Sorry for Ad in Which Boys Gawk at Cleavage In Davos Speech, Trump Rejects 'Prophets of Doom' Prince Harry Arrives in Canada, Which Shrugs Human-to-Human Transmission of China Virus Confirmed Man Tricked Women Into Shocking Themselves: Court It's a Big Day for Huawei Exec Detained in Canada 'All the Terrorists Have Been Eliminated' Kenya's president says 14 people were killed in attack on luxury hotel Posted Jan 16, 2019 12:11 AM CST In this grab taken from security camera footage released to the local media, an armed attacker walks in the compound of a hotel, in Nairobi, Kenya, Tuesday, Jan. 15, 2019. (Security Camera Footage via AP) (Newser) – Kenyan President Uhuru Kenyatta says 14 people were killed in Tuesday's attack on a hotel complex in the capital and the operation to neutralize the attackers is now over. Kenyatta did not say Wednesday how many attackers were involved. He urged Kenyans to "go back to work without fear," saying the East African country is safe for citizens and visitors. Al-Shabab—a Somalia-based Islamic extremist group allied to al-Qaeda—claimed responsibility for the carnage at the Dusit D2 hotel complex, which includes bars, restaurants, offices, and banks in Nairobi's well-to-do Westlands neighborhood. "All the terrorists have been eliminated," said Kenyatta per the AP. The BBC reports that the Kenyan Red Cross puts the death toll higher, at 24. Kenyan police said early Wednesday there was still an active security operation ongoing after they announced overnight that all buildings in the hotel complex had been secured, the AP reports. Sporadic gunfire still rang out through the morning. Scores of people were rescued at daybreak as police continued what they called a mopping-up exercise. The attack started with multiple suicide car bombs which breached the security gates of the complex and was followed by an invasion of at least four armed men. (Read more Kenya stories.) Next on Newser: Furloughed by the Shutdown? Denver Will Pay Your Mortgage ?????Mask????? Where's Obama to save the day. He's people needs help. Our media spends so much time on politics we lose sight of what is happening in the world as nations and warlords stake their claims to power.	cc/2020-05/en_middle_0111.json.gz/line2871
__label__wiki	0.952702	0.952702	Tags: michael cohen \| robert mueller \| donald trump \| russia \| pardon ABC: Cohen Has Spoken With Mueller's Team Multiple Times About Russia, Pardon (AP Photo/Craig Ruttle, File) By Jason Devaney \| Thursday, 20 September 2018 05:03 PM Members of special counsel Robert Mueller's team and U.S. attorneys have interviewed President Donald Trump's former lawyer Michael Cohen multiple times over the last month about all things Russia and whether Trump spoke about pardoning Cohen, according to a new report. ABC News reported Thursday that Cohen has sat down with investigators in New York City and Washington, D.C. for hours at a time. Mueller is investigating whether the Trump campaign worked with the Russians to defeat Democrat Hillary Clinton in the 2016 election. Cohen was subjected to raids of his offices, home, and hotel room earlier this year, and last month he pleaded guilty to campaign finance violations and other financial crimes related to payouts he made to women who claimed they had affairs with Trump. Cohen told members of the House Intelligence Committee last year that collusion between the Trump campaign and Russia did not exist. It's unclear if he has changed his tune, now that he's facing jail time as part of his plea deal. ABC reported that Cohen is voluntarily cooperating with investigators, and that it's not guaranteed he will receive a lighter sentence in December. The news outlet also reported that Cohen is cooperating with a New York investigation examining Trump's charity organization and his business. Trump has denied that his campaign had an improper relationship with the Russians. He defended Cohen for a time, particularly after the raids in April, but has since bashed his former attorney. Over the summer, Cohen released a tape of a conversation he had with Trump that dated back to 2016, before the election. The pair could be heard discussing a payment arrangement to a Playboy model who said she and Trump had an affair years before. Trump responded to the tape's release by asking, "What kind of a lawyer would tape a client? So sad!" Cohen did come to Trump's defense in August, however, when Omarosa Manigault Newman wrote in her book that Trump ate a note that Cohen once handed to him. "I saw NO such thing and am shocked anyone would take this seriously," Cohen said. Axios Poll: Americans Believe Cohen, But Don't Want Impeachment Lewandowski 'Warned Everybody' Cohen Was 'a Problem' michael cohen, robert mueller, donald trump, russia, pardon Thursday, 20 September 2018 05:03 PM Roe V. Wade Anniversary: Case Facing New Challenges On the 47th anniversary Wednesday, Roe v. Wade faces serious challenges in the months ahead on case that legalized abort . . .	cc/2020-05/en_middle_0111.json.gz/line2872
__label__cc	0.578918	0.421082	July 18, 2019 News Coastal Commission approves Morro Bay sewer project By Karen Garcia The California Coastal Commission unanimously approved on July 11 plans for the construction of Morro Bay's Water Reclamation Facility amid community protest. MOVING FORWARD After years of public input, meetings, and potential sewer locations, the Morro Bay Water Reclamation Facility received approval from the Coastal Commission. Among the individual residents who spoke against the project during public comment, representatives from Citizens for Affordable Living, Morro Bay Action Team, and Home Front Environmental Justice Morro Bay also expressed their opposition. "This consolidated hearing violates the Coastal Commission's own mission statement and code based on the substantial amount of Morro Bay residents' protests against this rate increase, the associated illegal results of the Proposition 218 as dictated by the Morro Bay City Council, and based on the incomplete status of critical studies," said Dan Sedley, co-chair of the Citizens for Affordable Living. In order to fund the nearly $125 million cost of construction, the city held a Proposition 218 hearing to increase household water and sewer bills by a maximum of $41 per month—it passed September 2018. Residents challenged the City Council for not counting 1,000 of the protest votes. The city had deemed them not valid because they were either undated or marked with a date that was prior to the public notice of the proposed rate increase. In 2019, the city counted and validated the protest votes in question, but the resulted amount was not enough to prohibit the council from approving the rate hike. Another funding avenue for the city is a state revolving low-interest loan, which it's currently applying for, and an Environmental Protection Agency low-interest federal loan. If the city is successfully approves it, such loans could take another $5 to $7 off a month of the surcharge. Protesters also raised the issue of affordability regarding the rate hike, not enough public input, and claimed the city of Morro Bay is rushing the project. Dan Carl, the Coastal Commission's deputy director, said the commission respectfully disagrees. The surcharge, he said, is meant to pay for the project and ensure a stable funding stream for the future. "As mentioned before, the city has fostered significant local participation including creating a citizen's advisory committee, having over 50 public meetings on the project over the past two years alone, and making project changes based on that public input," Carl said. Morro Bay City Manager Scott Collins said there isn't a rush on the project as it started in 2003. "This commission gave us the proper and appropriate direction to move this massive public infrastructure inland to protect it from coastal hazards and preserve this important infrastructure for future generations," Collins said. The long anticipated Water Reclamation Facility is slated to be at the intersection of South Bay Boulevard and Highway 1. « SLO Rep's The Little Mermaid Jr. ma… \| The California Mid-State Fair has t… » A campus divided: Cal Poly attempts to address racial tension Jurors will likely see photos of victim killed in fatal 2016 accident More by Karen Garcia The U.S. Census Bureau is looking to fill temporary employment positions locally Morro Bay takes first steps in preserving its dog beach SLO Food Bank is looking to fill its CEO position	cc/2020-05/en_middle_0111.json.gz/line2873
__label__wiki	0.921755	0.921755	Richard Brody Whit Stillman’s “The Cosmopolitans” By Richard Brody Adam Brody (left) and Adriano Giannini in “The Cosmopolitans.” Photograph courtesy Amazon Video Twenty-four years after the release of his first feature, “Metropolitan,” and two years after the release of his fourth, “Damsels in Distress,” Whit Stillman—the cinema’s novelist of manners, who reveals deep and enduring patterns beneath the shimmer of apparent frivolities—has written, directed, and produced the twenty-six-minute pilot of a TV-like series, “The Cosmopolitans,” for Amazon (where it premières tomorrow). It has a classical setup—Americans and other foreigners, members of a self-anointed social whirl, tripping through Paris—that, from the start, Stillman makes entirely his own, rendering it both contemporary and anachronistic, of the moment and rooted in time. There are no Fitzgeralds or Hemingways, no Steins or Pounds, in Stillman’s still-young set of expatriates. (Or, rather, there is one Hemingway—Dree, Ernest’s great-granddaughter, who plays one of the American expats.) If there’s artistic ambition and aesthetic adventure at work among the group that he gathers, it isn’t yet evident; there are no late-night discussions of lofty creative ideals. Rather, there’s love and real estate—and a constant jockeying for a nose ahead in the competition for esteem (or “reputation”). Cafés there are: the series has a long café scene up front, in which two American men, Jimmy (Adam Brody) and Hal (Jordan Rountree), talk with Sandro (Adriano Giannini), an Italian cynic of a certain age, who offers the young men aphoristically critical life advice and gives them a display of knowing worldliness that sparks both action and confusion—and that lures a young woman from the next table. Her story, a fragment of it, involves someone who seems like a French realtor coaxing her into a tiny and ill-appointed maid’s room in a great neighborhood in Paris.* The facts that emerge prove even more telling, but in any case the woman—Aubrey Lee (Carrie MacLemore), a graceful and curious Southerner—is moving, because of a breakup with the French man whom she followed to Paris. Hal, meanwhile, is in an on-and-off relationship with a French woman, Clémence (Clémentine Baert), who keeps him in her clutches—where he’s willing to remain. His romantic ordeal is the mainspring of discussion with Jimmy and Sandro, and it quickly becomes the undesired business of a fourth café-going expat, a woman whom the American men call “gold-coat girl” (Chloë Sévigny). Her deft mockery provokes a strange retort from Jimmy—that he and Hal are no mere Americans in Paris but have actually become Parisians. Jimmy’s boast (Stillman’s joke) hints at the director’s big subject. In a time of shifting and blended identities, Stillman remains a creator of sharply defined and seemingly rigid ones, of large differences of nature and culture alike—men and women (casually called girls), winners and losers, nationalities, stations of life. But, for Stillman, these categories are not simply stamps on his characters; they’re the very essence of his cinematic form. The hard-shelled, clearly labelled identity is a fiercely modern cinematic device. It’s one that (like many other such devices) is pressed into open view in Godard’s “Breathless,” in a dialogue riff that features Jean-Paul Belmondo categorizing stock characters akin to those present in the movie: “Informers inform, burglars burgle, murderers murder, lovers love.” There was then, in 1960—and there is, even more, now—a sort of critically popular faux-observational style of drama in which filmmakers keep what they know about their characters close to the vest and dose out information incrementally, by letting their undefined characters seem to define themselves by their actions, which viewers are allowed to peep in on in a pseudo-documentary style. By contrast, stock characters, labelled, are in a state of struggle from the moment they appear onscreen—a struggle with or against their own identities. Watching the observational drama as blanks fill themselves in evokes surprise; watching the drama of identity fuels suspense. This suspense is at the heart of Stillman’s drama; it’s how he gives a theatrical kick to situations that are spare on action. He equips his characters with expository dialogue that’s so smart and sharp that it, too, seems like a sort of action—thought in action. But then he sets those characters in motion and puts them to the test. He also puts their identities to the test, with the comedy and the drama of self-definition and self-creation (this comes to the fore especially in “Damsels in Distress”). In effect, for Stillman, exposition is a matter of form; the deft interweaving, from the very start of “The Cosmopolitans,” of disparate situations arises from a sense that labelling, whether through self-identification or the identification of others, is itself an act of high drama. The bulk of the pilot of “The Cosmopolitans” involves several of Stillman’s signature subjects. The first is a party: the male trio, plus Aubrey, head to a soirée at the posh apartment of an arrogantly wealthy Parisian acquaintance (or perhaps a German in Paris), Fritz (Freddy Åsblom). For Stillman, parties are laboratories where possibilities arise suddenly from the close and quickly ricocheting contacts of social atoms—and where social rules, hidden beneath the murky surface of daily life, emerge more clearly, in ritualized isolation. The second is something that happens at the party: a dance, but a formally patterned one where the rules are the very subject. It’s strange that, though every one of Stillman’s movies involves dancing, he is a cinematic master of bodies at rest; it’s as if he sees dance (the kind that has any value to him, the kind that has rules) as the physical counterpart to his socially sensitive characters’ dashing dialogue. Good talking, good dancing, good manners, good clothing, good eating. Within Stillman’s refined classicism is another sharp division of identities—between workers and drones. But it’s his very sense of beauty, his taste for the elegant moves on the board of complex social games, that crosses the lines; he makes frivolity itself seem essential, leisure a necessity, idleness an essential mode of creation—and money all the more important, yet still insufficient. There’s obviously something conservative about Stillman’s work, but, as nostalgia goes, his is an immensely productive and forward-looking one. His vision of a world in which traditional modes of behavior are preserved is also one in which those modes are still active—what he imports from the past is equally latent, though unexpressed, in the present. He isn’t so much reviving traditional ideas as revealing what he seems to consider enduring truths. The narrow social group in the pilot of “The Cosmopolitans” has tendrils that reach far and deep. Stillman’s sense of power is serious: within the febrile exclusivity of his glossy set is an underlying quest to clearly see the way in which the world works. The pilot of “The Cosmopolitans,” I hope, will win the series an enduring life. *Correction: Owing to an editing error, an earlier version of this post misidentified the profession of the man who coaxed Aubrey Lee into her apartment. Richard Brody began writing for The New Yorker in 1999. He writes about movies in his blog, The Front Row. He is the author of “Everything Is Cinema: The Working Life of Jean-Luc Godard.” Sign up for The New Yorker’s Movie Club Newsletter to get reviews of the current cinema, movie listings for the weekend ahead, and more. The Real “Knick” Steven Soderbergh’s TV series “The Knick” is thrilling, and should be supplemented with the fascinating, vivid memoirs of S. Josephine Baker, one of New York City’s early female doctors. Amazon is good for customers. But is it good for books? By George Packer	cc/2020-05/en_middle_0111.json.gz/line2875
__label__cc	0.660788	0.339212	NICE Introduces NICE COMPASS Compliance Assurance Software to Help Banks Automate Compliance to Meet Growing Financial Communication Regulations NICE COMPASS provides powerful compliance assurance recording automation tools, monitoring dashboards and reports to help financial institutions ensure enterprise-wide record-keeping compliance with MiFID II and other regulations Hoboken, N.J. – July 10, 2017 – Financial services organizations worldwide are under growing pressure from global regulations, including MAR, Dodd-Frank, Code of Conduct, and MiFID II, which broadens the scope of employees, asset classes, communication channels, and devices that need to be recorded and monitored, while also mandating proof of compliance. NICE COMPASS, a new solution from NICE (Nasdaq:NICE), minimizes the burden of these growing financial communication regulatory requirements, by helping financial institutions automate the compliance assurance process and by providing comprehensive evidence of compliance around the requirement to record employees that have information associated with a trade. "Financial institutions are drowning under the weight of expanding regulations that require them to record more conversations, for more users, across more modalities, and also prove their compliance," said Chris Wooten, Executive Vice President, NICE. "New regulations, such as MiFID II, are creating enormous headaches for financial institutions that today still very much rely on manual compliance assurance processes. NICE COMPASS reduces compliance risk and saves time by automating processes around compliance assurance and reporting, and responding to regulatory requests." "MiFID II and MAR are changing the surveillance game in terms of data capture, communications monitoring and analytics and evidencing to regulators," said Dan Simpson, Head of Research for JWG, a regulatory think-tank. "Firms need to be ready to meet these requirements from go live in January 2018 and this will require firms to boost current capabilities through implementing new technology solutions. NICE understands these requirements and the challenges involved in implementing them." NICE COMPASS adds three core capabilities on top of the NICE Trading Recording (NTR) platform: compliance assurance automation; real-time dashboards with automated reporting; and a single portal for managing compliance assurance and recording across the enterprise. Compliance Assurance Automation NICE COMPASS goes beyond recording to provide irrefutable evidence of compliance, a key requirement of MiFID II. It replaces manual recording checks, which are labor-intensive and prone to error, with scheduled, automated recording tests along every step of the way to prove that: all regulated personnel are in the system and being recorded, the audio quality is good; and all recordings are being properly secured and retained. Additional automated system assurance simulates calls to check that all system elements (network, gateway, PBX, recording, audio quality, archiving, and retention) are fully functional. In addition to achieving significant time savings, institutions can provide evidence of compliance at a moment's notice. MiFID II also stipulates that response to regulator requests must be timely. NICE COMPASS enables bulk download of up to 1.4 million calls per day to support faster turnaround times for investigations. Real-time Monitoring Dashboards and Automated Reporting A real-time compliance assurance dashboard makes it possible to visualize compliance assurance status, trends and exceptions across the enterprise, to reduce the risk of downtime. Additionally, compliance managers no longer need to waste time manually compiling data. NICE COMPASS' automated reports provide a thorough, step-by-step reconciliation of the entire recording process for all regulated users as proof of compliance. Centralized Management of Compliance Assurance and Recording NICE COMPASS reduces compliance risk and complexity by providing a single web-based portal for managing compliance assurance and recording across the enterprise. All functions of the system can be managed centrally, including: searching for recordings (across all locations, modalities and regulated users); implementing adds, moves or changes; configuring retention periods for asset classes, lines of business, and regulated user groups (based on specific global and/or regional regulations for records retention); and setting up rules for legal holds (up to 6 million holds per day). NICE COMPASS also offers an expanded API (Application Programming Interface) for integration with other bank systems. NICE COMPASS, together with NICE Trading Recording (NTR), provide a comprehensive solution for recording all communications (front office and back office, fixed and mobile), and for assuring complete compliance with financial regulations. Many of the world's leading banks rely on the NTR solution for reliable communications recording for turrets, desk phones, mobile phones, and Unified Communications platforms. NICE COMPASS and NTR are part of NICE's comprehensive suite of holistic surveillance solutions for the financial industry. NICE (Nasdaq:NICE) is the worldwide leading provider of both cloud and on-premises enterprise software solutions that empower organizations to make smarter decisions based on advanced analytics of structured and unstructured data. NICE helps organizations of all sizes deliver better customer service, ensure compliance, combat fraud and safeguard citizens. Over 25,000 organizations in more than 150 countries, including over 85 of the Fortune 100 companies, are using NICE solutions. www.nice.com. Corporate Media Contact Ilana Hart, +972-9-775-3818, ilana.hart@nice.com Investors Yisca Erez +972 9 775 3798, ir@nice.com, CET This press release contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. Such forward-looking statements, including the statements by Mr. Wooten, are based on the current beliefs, expectations and assumptions of the management of NICE Ltd. (the Company). In some cases, such forward-looking statements can be identified by terms such as believe, expect, may, will, intend, project, plan, estimate or similar words. Forward-looking statements are subject to a number of risks and uncertainties that could cause the actual results or performance of the Company to differ materially from those described herein, including but not limited to the impact of the global economic environment on the Company's customer base (particularly financial services firms) potentially impacting our business and financial condition; competition; changes in technology and market requirements; decline in demand for the Company's products; inability to timely develop and introduce new technologies, products and applications; difficulties or delays in absorbing and integrating acquired operations, products, technologies and personnel; loss of market share; an inability to maintain certain marketing and distribution arrangements; and the effect of newly enacted or modified laws, regulation or standards on the Company and our products. For a more detailed description of the risk factors and uncertainties affecting the company, refer to the Company's reports filed from time to time with the Securities and Exchange Commission, including the Company's Annual Report on Form 20-F. The forward-looking statements contained in this press release are made as of the date of this press release, and the Company undertakes no obligation to update or revise them, except as required by law.	cc/2020-05/en_middle_0111.json.gz/line2877
__label__cc	0.551937	0.448063	Art Fix of Nipissing making social change in North Bay Search the North Bay Nugget Training opportunities offered for people with lived experience of mental health and substance use issues Lindsay Sullivan / Special to The Nugget More from Lindsay Sullivan / Special to The Nugget Published on: November 23, 2018 \| Last Updated: November 23, 2018 1:39 AM EST Elbereth Steward, 14, created pipe cleaner dragons for the Art Fix Fall Art Training Showcase Thursday at the White Water Gallery. Photo by Cody Storm Cooper North Bay is rich with artistic talent, and so I am super-excited about creating accessible professional training opportunities, so people can pursue their own artistic goals. Together, we are building a community of people making social change through the arts. Art training program co-ordinator Lindsay Sullivan The art training program is being hosted by Art Fix of Nipissing with mentorship from Workman Arts, a Toronto-based organization that has been hosting such programming for more than 30 years, as part of the Workman Arts Scaling Project. The project is funded by the Ontario Trillium Foundation. Through this initiative, the project’s partners want to raise awareness of the prevalence of social isolation in people with lived experience of mental health and substance use issues, and the benefits of participating in the arts as an effective way to increase the sense of belonging to a community, expand social networks and build social skills. “Over the past two years, we have been facilitating skill-share workshops. Participants and instructors alike have been building boatloads of confidence, and I can’t wait to see what we can do with these new resources,” says Mitchell Ellam, Art Fix studio manager. Art Fix is an art for social change collective. It’s mission is to: • Facilitate aspiring, emerging and established artists with a lived experience of mental health and substance use issues to advance their artistic practice and art form through arts training programs, public performance and exhibition opportunities, and partnering with other art organizations. • Facilitate the overall well-being and social connectedness of Art Fix program participants • Engage artists and audiences across the Nipissing-Timiskaming region through public presentations of visual, performing, literary and media arts that are as close to home and accessible as possible. • Promote social change for wellness by facilitating greater public understanding of mental health and substance use, stigma and structural oppression through the creation, presentation and discussion of work by aspiring, emerging and established artists with lived experience. Workman Arts is an arts and mental health organization in Toronto known for its artistic collaborations, presentations, knowledge exchange, best practices and research on the impact of the arts on the quality of life of people living with mental health and addiction issues. Adele Landry created the charcoal drawing Never Got Home for the Art Fix Fall Art Training Showcase Thursday at the White Water Gallery. Landry, who is new to being an artist, drew Never Got Home after taking her first four art classes through Art Fix.Photo by Cody Storm Cooper Workman Arts supports the creative goals of emerging and established artists with mental health and addiction issues by providing a safe, nurturing environment where artistic projects, professional opportunities and personal and professional networks are developed and fostered. www.workmanarts.com After a successful first fall season of art training workshops, provided through Art Fix of Nipissing in partnership with the Workman Arts Scaling Project, we are gearing up for another season full of professional art training, creativity and fun. The winter season is set to offer free workshops in still life drawing, life drawing, painting techniques, professional development, printmaking and music. Weekly classes will be held at the White Water Gallery for individuals who self-identify with mental health and substance use lived experience. Registration for the winter season will be open on Dec. 6 and 7. Registration will occur in person on those days from noon-5 pm, or by appointment at the gallery, 122 Main St. E. Classes are free, but you must be registered. Interested participants can learn more by calling (705) 476 2444 or emailing art.fix.training@gmail.com Lindsay Sullivan is art training program co-ordinator for Workman Arts/ Art Fix of Nipissing Kerry Lynn Peltier created a mixed-media piece for the Art Fix Fall Art Training Showcase Thursday at the White Water Gallery. Inspired by her own pregnancy, Peltier first created a pregnant belly and turned it into an eyeball to represent “Whatever I see, the child sees.â She named the piece Unveiling Mysteries and Powerful Insight.Photo by Cody Storm Cooper Crash slows traffic Saginaw rallies to beat Troops in OT Canadian Blood Services to end North Bay's mobile blood clinic Thursday Education workers ‘left out’ Stolen vehicle recovered in Sturgeon Falls, two charged Bonfield looking ahead to climate change impact © 2020 North Bay Nugget. All rights reserved.	cc/2020-05/en_middle_0111.json.gz/line2881
__label__wiki	0.721485	0.721485	About NUJ Wales The NUJ represents workers across all areas of the media industry in Wales including the BBC and ITV, local radio, newspapers, magazines, books and PR. We represent a large number of freelance journalists and photographers, and those working in community journalism and hyperlocal hubs. Members in Wales are organised in geographic branches that include Cardiff and South East Wales, Swansea, Shropshire and North Wales Coast. There is also a specialist branch for staff at the BBC. Each branch elects representatives to sit on the NUJ Welsh executive council, along with elected representatives from all industrial sectors of the NUJ. The council meets to plan the work of the NUJ in Wales - recruitment, campaigning, political lobbying, training and other issues. The interests of NUJ members in Wales are also represented by an elected member (or job share) to the national executive council. If you are an NUJ member facing any issue at work, or you simply want to find out more about getting involved and active in the NUJ in Wales speak to a local NUJ representative. A media manifesto for Wales visible, accountable, diverse Ahead of the 2016 National Assembly for Wales elections, the NUJ Welsh executive council has produced a manifesto for the media, in consultation with the broader union leadership. The document is intended to inform political parties about the challenges facing the media in Wales. It is co-sponsored by the Media Reform Coalition. Go to the NUJ training in Wales website. Find out about the Welsh Government-subsidised professional skills training, mentoring and networking events in Wales. Education in Wales View a list of education providers in Wales. Read the latest news from Wales. Trades councils Trades union councils and county associations are an important part of the labour movement, bringing together activists at a grassroots level and representing the trade union movement to the broader community. The NUJ encourages all brances to affiliate to their local trades union council. The 2013 directory of trades union councils and county associations lists all 159 registered trades union councils and 26 county associations in England and Wales, by order of the region. Headland House – London Welsh executive council Wales publications Wales training Media education in Wales Campaigns in Wales Media ownership in Wales	cc/2020-05/en_middle_0111.json.gz/line2882
__label__wiki	0.976111	0.976111	Underwood's bill to combat robocalls passes House of Representatives By ALEX ORTIZEmailFollow Adam Jomant for Shaw Media Lauren Underwood A bill to combat unwanted robocalls that was supported by U.S. Rep. Lauren Underwood, D-Naperville, passed the House of Representatives on Wednesday. The Stopping Bad Robocalls Act, H.R. 3375, passed overwhelmingly with bipartisan support and only three votes against it. The bill came about as an estimated 47.8 billion robocalls were placed nationwide last year, an increase of 17 billion calls over previous years, according to a news release. "Robocalls aren't just annoying — they can be dangerous," Underwood said in the release. "They're used by fraudsters and unscrupulous debt collectors to scare hard-working Americans into falling for their scams." Underwood spoke on the House floor about the bill and said that so far in 2019, the average American has received 64 robocalls and that half of all calls to cell phones nationwide are robocalls. She added that a meeting with her staff about the bill was "literally interrupted by two different robocalls." She said the bill will strengthen enforcement against scammers and ensure consumers can block calls at no extra charge. The bill would also require the Federal Communications Commission to establish a hospital robocall working group to ensure robocalls don't interrupt the work of health care providers. Underwood bill aims to cut health care costs Underwood: Domestic terrorism is a threat to national security Underwood talks health care, Congressional gridlock at town hall in Shorewood Rep. Lauren Underwood backs impeachment investigation in House	cc/2020-05/en_middle_0111.json.gz/line2884
__label__cc	0.673662	0.326338	100.3 The Ride Hot Country 97-9 102-5 URock 790 KXXX NewsTalk 730 KLOE SHERRIF’S OFFICE BOOKINGS Curtis Duncan Greg Boyson Karen “Trixie” Emerick Paul Heskett Ross Volkmer Sacha Sanguinetti Shane Timson Hoxie, Quinter among communities receiving $2.1 million in funds andy lambertOctober 14, 2013 TOPEKA – Ten Kansas communities will share $2.1 million in funding to build moderate-income housing and infrastructure in rural areas. The Moderate-Income Housing (MIH) Program, an initiative funded by the State of Kansas and administered by Kansas Housing Resources Corporation (KHRC), works to help cities and counties develop multi-family rental units, single-family for-purchase homes, and water, sewer and street extensions in communities with populations fewer than 60,000 people. MIH funding can also be used to finance construction costs, rehabilitate unsafe or dilapidated housing, and offer down-payment and closing-cost assistance to homebuyers. “Now in its second year, the Moderate-Income Housing Program offers an important resource for rural cities and towns undertaking housing initiatives,” said Dennis L. Mesa, Executive Director of KHRC. “When we support activities that revitalize communities, we raise the standard of living for all families who live there,” said Mesa. The need for moderate-income, workforce housing throughout Kansas is growing. Currently, there are 97 counties and over 600 communities eligible to apply for MIH funding. These communities comprise approximately 68 percent of the state’s total population. Numerous municipalities statewide are experiencing opportunities for economic development and job growth, but the lack of adequate, affordable housing is posing roadblocks to new expansion. Communities receiving 2013 MIH awards include: 2013 MODERATE-INCOME HOUSING AWARDS AMOUNT City of Cottonwood Falls $100,000 City of Hoxie $382,451 City of Hugoton $250,000 City of Humboldt $100,000 City of Liberal $350,000 City of Lyons $200,000 City of Parsons $100,000 City of Quinter $400,000 City of Stockton $71,000 Stafford County $168,000 TOTAL $2,121,451 To learn more about the communities receiving 2013 MIH Awards, click here KHRC defines moderate-income as households earning between 60 and 150 percent of the U.S. Department of Housing and Urban Development’s FY2013 income limits, or income ranging from $23,220 and $109,350 depending on family size. In 2012, the MIH program provided $2.3 million to develop new housing and infrastructure development in Kansas, leveraging $22.1 million in private funding. This year’s awards are expected to leverage $18.3 million in local funding, and create or preserve 146 housing units in Kansas. Kansas Housing Resources Corporation is a self-supporting, public corporation which serves as the primary administrator of federal housing programs for the State of Kansas. Our mission is to increase the availability of affordable, quality and accessible housing for low and moderate-income Kansans. —Press release via KHRC Uncategorized , Governor Colyer issues State of Disaster decl... Homicide in Goodland being investigated by KB... New class of Kansas Highway Patrol troopers g... 3 members of alleged “carnival mafia... Sports Sports News Trojan Basketball Splits with Panth... COLBY, Kan. — Monday night, the Colby Community College Trojans hosted their fourth consecutive le... January 21, 2020 Comments ICYMI: Antwain Scales – Janua... ICYMI: Michael Bruntz – Huske... ICYMI: Jeffrey Essary – Janua... Colby Community College O... January 17, 2020Comments Today In Kansas Report &#... © 2007 - 2020 - EEO - KRDQ - KXXX - KLOE - KKCI - KWGB	cc/2020-05/en_middle_0111.json.gz/line2885
__label__cc	0.660412	0.339588	Baseball Podcasts Football Podcasts Hockey Podcasts Basketball Podcasts Hockey / NHL / Other The 10 Most Defining Devils Wins this Decade: U.S.S. Golden Knights by Luke Garrison · December 22, 2019 NEWARK, NJ - DECEMBER 14: Nico Hischier #13 of the New Jersey Devils celebrates while laying on the ice after scoring the game winning goal in overtime against the Vegas Golden Knights at Prudential Center on December 14, 2018 in Newark, New Jersey. The Devils defeated the Golden Knoghts 5-4. (Photo by Andy Marlin/NHLI via Getty Images) 2020 is almost here, and the New Jersey Devils are hoping their bad seasons could end with a new decade. A new decade could show signs of a team changing, and the New Jersey Devils could be one of them. Once the Devils fix their issues with a new head coach and find a way to play better as a team, we could see a whole new Devils team this next decade. Let’s take these last couple of days of the decade to look at the top 10 best wins for the New Jersey Devils in this decade. There seems to not be any luck with this one for the Vegas Golden Knights. How Good Did This Game Start Out for the Knights and Bad for the Devils? On December 14th, 2018 the Devils faced off against the Vegas Golden Knights. The Knights were in their 2nd year of being a NHL Franchise. The Devils were coming off their first playoff appearance in 6 years. I was in attendance for this game, it seemed it was a good game for Vegas, and they started hot. 3 goals were scored by the Golden Knights, one early by Alex Tuch, and one later from William Karlsson. Cory Schneider let the third goal in when William Carrier shot and Schneider mishandled his save and it went in. Former Devils coach John Hynes pulled Schneider from the game and put in former Devils goalie Keith Kinkaid. In the 2nd period, Travis Zajac got one past Marc-Andre Fleury to get the Devils on the board. However, the Knights got one back on the PP with William Karlsson‘s second to extend the Knights lead. That would be the last time the Knights scored in the game. What Did the Devils do Change the Outcome of the Game? Now here comes what makes this game memorable, the Devils fighting not to lose. Miles Wood shot a pass that was open to him to make it 4-2. Then in the 3rd period, Kyle Palmieri beat Fleury on a wraparound through the five-hole to cut the lead to one. With 5:05 left, an attempt from Brett Seney was put in to tie the game. However, on replay it showed that Nick Holden of the Knight put the puck in his net. While all of this was happening Keith Kinkaid kept the Devils from losing by playing one of his best games. I was in complete shock of what I just witnessed. Then it all came down to some Overtime Heroics (see what I did there). In overtime, it didn’t take long for the game to end. 31 seconds in, a pass from Marcus Johansson was given to Nico Hischier. Hischier, trying to deke out Fleury, fell down and put the puck past him, giving the Devils the win. The crowd could not believe what they saw from the team. However, the Knights challenged the goal for goaltender interference. With the Devils and their ref issues, I thought the goal was not going to count. Upon replay, the goal for sure looked like it was going to count. After the review, the refs called it a good goal and the Devils won the game 5-4. What Happened Next With the New Jersey Devils That Season? Unfortunately, the Devils were not good enough unlike the previous year to make the playoffs. They finished as the 3rd worst team in the league behind the Los Angeles Kings, and the Ottawa Senators. However, they ended up winning the NHL Lottery Draft that year which allowed them to draft Jack Hughes. Follow me on Twitter for more Devils content @SonicHockeyFan Follow us on Twitter @OTHeroics1 and Instagram @otsports. Come discuss this and everything to do with sports at the Overtime Heroics forums! Check out more articles in our Hockey section! New designs being dropped in our merch store! Be sure to check out the newest threads! Vegas Golden Knights Gerard Gallant Fired Fantasy Hockey Weekend Streamers: Week 2 Vegas Golden Knights Projected Lines for 2019-20 Next story Another Record Falls: Michael Thomas Breaks the Single Season Reception Record Previous story Trail Blazers Have Won 4 In A Row OTH Heroics Twitter OTH Daily Podcast Subscribe to Overtime Heroics! Enter your e-mail address for updates on our latest content! Overtime Heroics © 2020. All Rights Reserved.	cc/2020-05/en_middle_0111.json.gz/line2889
__label__wiki	0.735416	0.735416	Music Notes: A Flagship for the new season Search the Owen Sound Sun Times These weeks between a hot summer and cold winter still have plenty to offer, even if they do feel far too short. More from Matt Olson Published on: September 11, 2019 \| Last Updated: September 11, 2019 8:23 PM EDT Edmonton-based singer Danielle Dayton is set to perform at the Black Cat Tavern on Monday, Sept. 16. Matt Smith / Saskatoon StarPhoenix Everything is starting again: school, fall (best season of the year), the orchestra seasons (both jazz and classical), the venue seasons, and more. This is a great time of year. That’s probably not the most popular opinion in the prairie provinces. Usually when the summer ends, everyone just starts to dread the cold chill of winter that always seems to swoop in without much warning. But there are a handful of weeks between the summer and the winter, no matter what anyone tells you. And these weeks are absolutely loaded with top-tier entertainment. When: Thursday, Sept. 12 Where: Capitol Music Club What: This flagship has sailed into Saskatoon from quite far away — New Mexico. And the romance isn’t just in the title — the duo of Shawn Fisher and Jordyn Jackson are also married. If that wasn’t enough, just know that these two are musically brilliant. Magnificently sharp and precise harmonies for the powerful lyrics make for a richly colourful and gentle folk-rock experiment. They’re a pretty impressive musical team, and their journey to this point is more than a little bit picturesque. The music is top-notch, and in the end that trumps everything else. The Bassment suits up for a huge season of music StarPhoenix’s Cam Fuller honoured with award from theatre community Danielle Dayton When: Monday, Sept. 16 Where: Black Cat Tavern What: Dayton, a singer-songwriter out of Edmonton, blends a heavy and pulsing rock beat with soulful and smoky vocals. If you listen hard enough, you can hear the gentle tinge of country flavour in her music (especially when things slow down), but Dayton fills a nice alt-rock niche — she doesn’t sound folksy and she doesn’t sound like a pseudo-pop singer. Far from it: Dayton’s low-range and powerful singing style distances her from a lot of the popular music traps of the day and situates her firmly among those musicians who are able to find — and revel — in their own unique sound. Mike Klein & Friends When: Friday, Sept. 13 Where: The Bassment What:What better way to get The Bassment’s newest concert season into full swing than with Saskatchewan string aficionado Mike Klein? Originally from Melfort, Klein has carved out a career playing bluegrass music and old-fashioned fiddle tunes. He was classically trained on the violin and the piano, and can also play the mandolin and the banjo with deft fingers. The “& friends” part of the show includes top-notch acoustic musicians from around the province to play old standards and songs from Klein’s newest album, Over The Waves. The lineup at The Bassment is great this year — might as well start strong with a Sask-powered show. maolson@postmedia.com © 2020 Owen Sound Sun Times. All rights reserved.	cc/2020-05/en_middle_0111.json.gz/line2890
__label__wiki	0.914454	0.914454	September 13, 2019, 12:45 PM ET ‘My Dad Took A Shot At Me, And My Mom And My Brother Are Still Inside': Daughter Makes Harrowing Escape From Murder-Suicide Los Angeles city attorney Eric Lertzman killed his wife Sandra and son Michael before killing himself. His daughter managed to flee. By Gina Tron Horrific Family Tragedies When Parents Lost Control John Jonchuck Convicted of Murder For Dropping Daughter Off Bridge Wives Who Brutally Killed Husbands Who Killed Their Wives 7 Facts about Domestic and Intimate Partner Sexual Violence Kelsey Berreth Murder Suspect Arrested Disturbing Details of the Watts Family Tragedy 7 Facts About Incest and Family Sex Abuse Police: Michigan Man Fathered A Child With His 20-Year-Old Daughter Disturbing Details Of A Father, His Daughter And Their Alleged Baby Disturbing Details Around the 13 Allegedly Tortured California Siblings Facebook Video Shows Baby Crawling on Busy Street, Mother Arrested Facts About Elder Abuse And Prevention The Hart Tribe Crash Becomes A Crime Investigation Hart Family Crash Ruled Intentional, Jury Finds 7 Facts About Child Abuse and Prevention A Los Angeles city attorney killed his wife and teen son in a murder-suicide and attempted to kill his daughter but she managed to crawl out a window and escaped, authorities say. Police were called to a home in the Los Angeles neighborhood of Northridge Wednesday morning after a report of a shooting. When officers arrived “they discovered three dead inside the residence,” the LAPD said in a press release. Eric Lertzman, 60, his wife Sandra and their 19-year-old son Michael were all dead of gunshot wounds. “The investigation ultimately revealed that 60-year-old Eric Lertzman, had shot and killed his wife Sandra in their master-bedroom,” police stated. “He then walked across the hall where he attempted to shoot a female adult. She escaped and locked herself in the hallway bathroom.” That woman, his daughter, was able to escape through the bathroom window. While she was fleeing, her dad shot her brother to death. He then returned to the master bedroom and killed himself. Eric and Sandy Lertzman Photo: Facebook The daughter, who has not been publicly identified, ran to neighbor Greg Demos' home for help. Demo told KTLA that the she was “upset, confused, distraught, somewhat in shock" and even a "little bit embarrassed" as she told him, “My dad took a shot at me, and my mom and my brother are still inside.'" While a motive is still being determined, police cited “the recent loss of a loved one and on-going health issues played significant roll.” Eric Lertzman's mother died in late August, according to an obituary. City Attorney Mike Feuer reacted to his colleague's murder-suicide said in a statement, which reads in part: “This is a horrible tragedy. As we search for answers to how this could happen, we mourn the victims and envelop those left behind with our love during this time of unbearable loss.” Michael worked as a camp counselor at the American Jewish University’s Camp Alonim in Simi Valley, according to the camp, which praised the slain teen for his “personal warmth, his gentle spirit, his wide smile, and his infectious enthusiasm.” 'Distraught' Dad Comes Home To Find Two Daughters Dead College Friends Die In Apparent Murder-Suicide Mom Allegedly Admits To Killing Her 3 Children	cc/2020-05/en_middle_0111.json.gz/line2892
__label__cc	0.528337	0.471663	Home >> Advice >> How to get Signed to an Indie Record Label How to get Signed to an Indie Record Label Open Mic UK \| 05/02/19 The dream of a record contract remains the goal of every aspiring artist and hard-working band or music act. Factors including talent, hard work, distinctive appeal plus a little luck and even more hard work all play a part in getting signed, and here’s how to tip the odds of a deal with the indie label of your dreams in your favour. Build up a body of work One or two great tracks crafted in the eagerness to get going might be okay for a calling card and to start building your reputation. But the offer of any contract will depend on your act proving that it can produce a volume of consistent, high-quality music that will form the first album or playlist, so a strong body of work is essential. Indie labels might be more flexible than the majors when it comes to signing acts, but they will still expect a long-term level of musical production from their artists. While working, keep all demos, mixes and original data (including handwritten or digital notes) stored safely in secure cloud and offline storage to protect your assets. Not only could this prove of value in future, but help protect in copyright lawsuits and other battles. 9 Places for UK Singers to be Spotted by Record Label Talent Scouts Performing frequently and submitting your tracks to music sites is great for exposure, but where are the places you should you be seen if you want to attract record labels and management interest? We talked to talent scout and music promoter, Chris Grayston, to get his take on some of the UK’s top music industry... Read more » Play your heart out Whether playing a wedding, open mic night, school disco, club rave, pub gig or local festival, it remains a maxim that your act should play as if in front of a baying arena or full hall, packed with fans. Being able to demonstrate musicianship, stagecraft and to build and maintain a rapport with the audience have got more bands signed over the years than any particular song. Learn from your idols and other bands that you play with how to judge the mood of an audience and how to get them excited, whatever type of music you play. Indie A&R managers or label owners scouting will appreciate that effort, increasing your visibility and boosting your chances of a contract, while a good live act will help attract new fans and help spread the word. Book every gig you can, and have merchandise and music to sell at each show, as this can help fund other work as you continue to seek a record deal. With fewer music sales due to streaming, every physical sale is vital for a new act and well worth investing in good quality merchandise products. Caution: Shameless plug ahead! Continue reading below. Use tech and social media to your advantage Every act has an online presence, from a band website to social media pages and accounts to SoundCloud, Spotify and other playlist services. Bring the enthusiasm of your act to these accounts, treat new fans with all the love and interest you can afford, and try to grow your audience online through the promotion of events, new music releases, previews and sharing news and information across fans, other acts, music press and wherever appropriate. More tech-savvy artists might also want their own app as a centerpiece of all their other digital efforts. This can encourage sharing, and demonstrate your commitment to building your fan base when it comes to searching for a contract. While indies can be more innovative than majors when it comes to promoting artists online, they will appreciate the effort your act has made, and that it will save them time and effort in building your online presence. Video and promotion If you have the resources, music videos are a great way to promote your band, either animated lyric videos or filmed video efforts featuring the band. As with many amateur movie makers, maximising every dollar or pound spent is key. Some acts can make a £250 video look like a near-professional effort, while animators can create high-art for low-cost if you don’t have the inclination to go before the camera. All of which helps raise your profile and show you are serious about making it in the music industry. It will help create an image or tone to the band that indie labels will be keen to work with, rather than having to do all the work for you. How to Shoot a Low-Budget Music Video Music videos are a great way to shine a spotlight on your music and can make yourself look more attractive and professional to promoters and bookers. Even with no budget or experience, a professional looking music video can be made with surprisingly few resources. Here are our top tips on How to shoot a music... Read more » Save and invest wisely Any money you, the band or act makes from sales should be focused on building the “brand” and helping raise awareness in areas that are more likely to get you signed. That means focus on getting more gigs, not a band holiday to shoot a video in the sun or endless parties that might be fun, but could give you a bad reputation. Indie labels are used to being financially astute and will prefer artists that look like a good investment over diva acts and those who are spending way above their budget. Don’t blow the deal and act like a professional If you’re offered a record deal, or are the interest of multiple indie labels, negotiate firmly but fairly – and don’t try to screw over one label. Look for the right label that you feel comfortable with, has helped promote acts that your recognise as successful and appear to have your long term interests at heart over a quick-deal. Some acts fall apart over signing a deal, others try to be too greedy, but just like any other business transaction, a long term goal that is best for both parties has to be the ideal result. In negotiations and communications with a label and industry workers, you need to provide clear communication with them, respond in a timely fashion, and act as you would when discussing any other business deal, even if this is new territory for you. Whatever the scale of your ambition, if the focus is to get a record deal, then you have to play by some traditional musical industry rules. But that doesn’t mean you have to compromise or pander to labels. Label managers will appreciate an act with an individual voice or style, that stand out in terms of music or artistic vision. Did you enjoy our post on how to get signed to an indie record label? See our article on how to get signed to a record label and please comment below and share! Thanks to our Guest Writer Izaak Crook from AppInstitute, a SaaS App Builder platform that allows anyone to create their own iOS and Android app without writing a single line of code. https://www.openmicuk.co.uk/advice/how-to-get-signed-to-an-indie-record-label/ Brilliant! Every bit of advice well worth investigating and working at. I especially agree “Being able to demonstrate musicianship, stagecraft and to build and maintain a rapport with the audience have got more bands signed over the years than any particular song.” Thanks, Donovan! Alison Incausti This is so practical and easy to follow. without step by step information like this it is hard to navigate. Thanks, that’s great to hear! Alison Inchausti Thnak you 🙂 Getting Started With Songwriting Lyrics Performance Tips for Music Duos and Groups Blogs: How to Submit, Promote and Get Featured by Music Bloggers How Singers Can Improve as Performers	cc/2020-05/en_middle_0111.json.gz/line2895
__label__wiki	0.541849	0.541849	O.C. housing’s worst slump since… O.C. housing’s worst slump since ’12 cut sales by 13% in Brea, Buena Park, Fullerton, La Habra, Placentia, Yorba Linda North Orange County sales in nine months totaled 3,103 vs. 3,563 a year earlier. PUBLISHED: June 19, 2019 at 7:19 pm \| UPDATED: July 1, 2019 at 11:26 am Homebuying in Brea, Buena Park, Fullerton, La Habra, La Palma, Placentia and Yorba Linda fell 13% in what was Orange County slowest nine months of sales since 2012. For nine consecutive months through April, CoreLogic housing stats show countywide sales failing to top the year-ago period. We wanted to see how these lethargic sales trends played out at the neighborhood level knowing that homebuying declined in roughly eight of nine local ZIP codes. ICYMI: Does California need another crash to create affordable homes? CoreLogic found these 19 trends in 13 ZIP codes covered by the Orange County Register’s North County News weekly, … 1. Purchases: Home sales in these nine months totaled 3,103 vs. 3,563 a year earlier, a decline of 13% in a year. 2. Who’s up: Prices increased in seven of the 13 ZIPs as sales rose in just two ZIPs. 3. Countywide: $720,000 median selling price, flat in the period. Orange County sales totaled 22,872 residences, existing and new, vs. 27,289 a year earlier, a decline of 16.2% in a year. Prices rose in 43 out of 83 Orange County ZIPs and sales were up in 9 out of 83 ZIPs. Here is how prices and sales moved in northern Orange County … 4. Brea 92821: $678,000 median, down 3.1% over 12 months. Price rank? 50th of 83 Orange County ZIPs. Sales of 250 vs. 308 a year earlier, a decline of 18.8% in a year. 5. Brea 92823: $780,000 median, up 3.4% over 12 months. Ranks 32nd priciest of 83 ZIPs. Sales of 65 vs. 78 a year earlier, a decline of 16.7% in a year. 6. Buena Park 90620: $575,000 median, down 0.7% over 12 months. Ranks 66th priciest of 83 ZIPs. Sales of 241 vs. 289 a year earlier, a decline of 16.6% in a year. 7. Buena Park 90621: $567,250 median, up 0.3% over 12 months. Ranks 69th priciest of 83 ZIPs. Sales of 194 vs. 237 a year earlier, a decline of 18.1% in a year. 8. Fullerton 92831: $610,000 median, up 6.2% over 12 months. Ranks 62nd priciest of 83 ZIPs. Sales of 187 vs. 217 a year earlier, a decline of 13.8% in a year. 9. Fullerton 92832: $565,500 median, up 10.8% over 12 months. Ranks 70th priciest of 83 ZIPs. Sales of 115 vs. 100 a year earlier, up 15.0% in a year. 10. Fullerton 92833: $600,000 median, down 1.6% over 12 months. Ranks 63rd priciest of 83 ZIPs. Sales of 298 vs. 392 a year earlier, a decline of 24.0% in a year. 11. Fullerton 92835: $752,500 median, up 3.2% over 12 months. Ranks 34th priciest of 83 ZIPs. Sales of 215 vs. 276 a year earlier, a decline of 22.1% in a year. 12. La Habra 90631: $545,500 median, up 2.9% over 12 months. Ranks 73rd priciest of 83 ZIPs. Sales of 438 vs. 450 a year earlier, a decline of 2.7% in a year. 13. La Palma 90623: $715,500 median, up 7.2% over 12 months. Ranks 41st priciest of 83 ZIPs. Sales of 67 vs. 95 a year earlier, a decline of 29.5% in a year. 14. Placentia 92870: $658,500 median, down 3.9% over 12 months. Ranks 53rd priciest of 83 ZIPs. Sales of 325 vs. 361 a year earlier, a decline of 10% in a year. 15. Yorba Linda 92886: $800,000 median, down 5.1% over 12 months. Ranks 26th priciest of 83 ZIPs. Sales of 488 vs. 545 a year earlier, a decline of 10.5% in a year. 16. Yorba Linda 92887: $797,500 median, down 10.7% over 12 months. Ranks 27th priciest of 83 ZIPs. Sales of 220 vs. 215 a year earlier, up 2.3% in a year. Sign up for The Home Stretch newsletter. Get weekly housing news on affordability, renting, buying, selling and more. Subscribe here. Plus, three more countywide trends found in nine months ended in April vs. the same period one year earlier … 17. Single-family-home resales: 13,720 Orange County sales vs. 16,058 a year earlier, a decline of 14.6% in the period. Median: $767,000 — a dip of 1% in the period. 18. Condo resales: 6,038 sales vs. 7,218 a year earlier, a decline of 16.3% in 12 months. Median: $500,000 — unchanged in the timeframe. 19. New homes: Builders sold 3,114 residences vs. 4,013 a year earlier, a decline of 22.4% in 12 months. Median: $981,500 — a rise of 7.3% in a year. Buyer competition fuels 16% jump in Southern California house sales Southern California house price gains pick up in November As solar mandate nears, will homebuilders be ready? Orange County house hunters help SoCal median sales price hit record high More in Housing HOA Homefront: New Year’s resolutions for HOA service providers Use your move to make big changes Tustin will get 400 new homes in $69 million deal	cc/2020-05/en_middle_0111.json.gz/line2897
__label__wiki	0.545419	0.545419	OLI - Sistemas Sanitários, S.A OLI UNVEILS THE OLI120 BLOCK AT THE BIG 5 OLI will launch the OLI120 Block, an exceptional in-wall cistern, at the BIG 5 – the International Building & Construction Show at the WorldTradeCenterin Dubai. The show will occur from the 23rd to the 26th of November. In addition to incorporating OLI cutting edge technology, the OLI120 Block and stands out due to its easy installation and the sturdiness of its encompassing EPS. In addition to OLI120 Block, OLI – who is in Hall 2, Stand 2F61 – will also unveil two new products: Blink control plate and SF100 outlet valve for one-piece ceramic cisterns. OLI stands for quality and sophistication The Boulevard - Lisbon Apartments, the latest luxury real estate development in Lisbon OLI 74 Plus 2 inlet valves contributes to Aqua+ Index Belas Clube de Campo is the first real estate project to be distinguished by ADENE - Energy Agency, with AQUA+, the new building water performance index. To celebrate World Toilet Day (November 19), OLI, a global brand of bathroom solutions, raised awareness of the fact that 2.4 billion people around the world do not have access to proper sanitation. OLI wins fourth international award Moon Black, OLI’s control plate, made of Vista Alegre porcelain, won the fourth international award this year. Easy Move range shines at TechDays The Easy Move range shone at the 5th edition of TechDays, a technological conference and show of innovation that took place in Aveiro from the 10th – 12th of October. Innovative bathroom at Decor Hotel OLI presented an innovative bathroom at Decor Hotel, the professional tradeshow for Equipotel, Construction, Products and Services for hotels and hospitality industry, which took place in FIL in Lisbon from the 24th to the 26th of October. OLI is a finalist for the 2019 European Business Awards OLI is the national winner and European finalist, in the Innovation category, of the European Business Awards 2019, in which 120,000 companies from 33 countries have applied. On September 28th we concluded OLI´s 65th anniversary festivities with the celebration of a Mass, by the Bishop of Aveiro, D. António Moiteiro, at the Vista Alegre Chapel, followed by dinner at the Montebelo Vista Alegre Hotel in Ílhavo. Visit OLI at DECOR HOTEL 2019 OLI will participate at DECOR HOTEL in Lisbon from October 24th -26th. Together with architects from around the world OLI's close connection with architecture is already a brand hallmark, so the participation in the 5th Edition of Archi Summit in Lisbon last July was another opportunity to consolidate OLI´s brand identity. In Montevideo to foster brand growth in Uruguay Uruguay is one of the key growth markets for OLI in Latin America. Therefore, OLI chose the capital, Montevideo, to organize a training session for local customers and installers. OLI presented a range of sanitary system solutions and shared up-to-date information as well as good installation practices. Seamless: a unique inspection plate The new inspection plate for concealed cisterns, Seamless, stands out from the competition by allowing it to be coated with the same finishing as your bathroom. Exclusive event presents new products to customers In June OLI brought together some of its top national clients at an exclusive event at the Olissippo Lapa Palace Hotel in Lisbon to present new products. OLI Reference Projects from all over the world OLI is present all over the world, in luxury hotels, modern hospitals, football stadiums and even museums. OLIpure – a cleaning solution! To demonstrate the potential of OLIpure a video was recently released promoting the product. The video explains the cleaning solution and how it is ideal for creating a fresh atmosphere in the bathroom. Because World Environment Day should be every day! World Environment Day is celebrated on June 5th and with it we revive what we do best at OLI! Seal Box, the new in-wall cistern It's called Seal Box and it's OLI's latest in-wall cistern. In addition to functionality and aesthetics this flushing cistern stands out by incorporating a wraparound box which safeguards against potential water infiltrations in the wall. Private Hospital of Madeira chooses OLI OLI was chosen to equip the newly inaugurated Private Hospital of Madeira (HPM), the first of that region. In Shanghai to grow in Asia At the end of May OLI took another important step in representing the brand in Asia by attending the international "Kitchen & Bath China" fair. Moon Black wins third international award Moon Black was awarded the German Innovation Award 2019 in the Excellence in Business to Consumer - Heating & Bathroom category. New website awarded at the Lusófonos Creativity Awards The new corporate website that OLI debuted earlier this year as part of its 65th anniversary, was awarded at the Lusophone Creativity Awards (Bronze Award in the Digital category). OLI supports Carrilho da Graça: Lisbon With the objective of maintaining a close relationship with architecture of excellence, OLI supports the international itinerary exhibition "Carrilho da Graça: Lisbon". The exhibition presents a selection of ten projects for the city of Lisbon designed by the architect João Carrilho da Graça from 1980 to 2015. OLI across borders OLI continues to focus on its international presence. In the last month, OLI debuted in Iceland with Vatnsvirkin. The brand was launched at an event that brought together more than 100 participants. OLI strengthens brand in Russia OLI is stepping up its influence in Russia and its neighbours in both the ceramic and retail markets. OLI is particularly attractive to those who seek to benefit from OLI's continuous investment in innovation and its productive capacity in Russia, where it has been manufacturing since 2016. OLI sponsors Riders for Moto2 and Moto3 World Championship For the 2019 season, OLI is sponsoring three riders. One rider in the Moto2 Federal Oil Gresini team, Sam Lowes, British. And two riders for the Moto3 Kommerling Gresini team, Riccardo Rossi, Italian, and Gabriel Rodrigo, Argentinean. Moto2 and Moto3 are two categories belonging to the World Motorcycle Championship organized by the International Motorcycling Federation (FIM). OLI in Brussels OLI, through DESCO, who represents the brand in Belgium, was present at BATIBOUW, the largest construction and urban rehabilitation fair in the country. OLI showcases innovative and sustainable solutions at ISH OLI is back at ISH, the world's largest bath, building and energy fair, which runs from March 11th-15th in Frankfurt, Germany, to introduce its innovations for the bath space. OLI launches new website In its 65th year of history, OLI, the Iberian leader in the production of flushing cisterns, introduces a new corporate website that materializes brand values and presents the best digital practices, such as simple menus, clean design and easy navigation. Sanitary modules for functional and modern bathrooms The QR-INOX and QR TOTAL sanitary modules with built-in high technology are two clean solutions which transform the bathroom into a sustainable, functional and modern space. OLI will be at MosBuild From April 2nd – 5th, OLI will be present at MosBuild (Pavilion 3, stand 133) in Moscow, Russia. OLI shines in Germany Hundreds of professionals from around the world experienced first-hand OLI´s novelties at ISH, the world's largest bath, building and energy fair, which recently took place in Frankfurt, Germany. Moon Black awarded with Design Plus The in-wall cistern control plate, Moon Black, is once again recognized for its design and has been awarded the Design Plus award, which will be presented in Germany at the ISH fair. OLI celebrates its 65th anniversary this year. The commemorations began yesterday, February 28th, the day before the official founding date, with the public presentation of the book "Our History", which reveals the major business milestones of the company led by the Oliveira family. Have you ever seen a black moon? "Moon Black" is a unique flush plate that is aesthetically pleasing with easily distinguished shapes. OLI training in Iraq OLI continues to invest in international training. Recently, a team was in Iraq promoting technical sessions aimed at industry professionals. Luxury hotel in Dubai chooses OLI OLI was chosen to equip the Ghaya Grand Hotel in Dubai. Considered a "local gem", this luxurious hotel equipped approximately 700 room bathrooms, suites and apartments with the "OLI 74 Plus Sanitarblock" in-wall cistern and the "Ria" control plate. OLI celebrates 65 years of success. The celebrations will begin in February, with the launch a book titled "Our History", and will continue throughout 2019, involving workers, customers, partners and the community. OLI products in train station in Israel The main railroad station of Israel - Tel Aviv Savidor Main Train Station - chose to equip their bathrooms with products from the Portuguese company OLI. OLI at ISH 2019 Come visit OLI´s stand at the ISH 2019 in Frankfurt OLI presentation for architects in Rome Last month, OLI participated in the 3rd annual ARCHITECT@WORK Roma, a major international architectural trade show, where it presented several solutions that combine design with sustainability. Support for the construction of domestic latrines in Laos Inadequate or non-existent sanitation and lack of hygiene are a threat to the lives and dignity of the population in Laos. Unhappy with this reality, the international NGO ADRA, based in The Netherlands, invited OLI to support a sanitation and hygiene project in the rural communities of this Southeast Asian country. OLI in Tanzania Recently OLI was in Tanzania, in Dar es Salaam, the largest city in the country, where it presented a portfolio of bath solutions specific to the African market, and organized a training session for 50 professionals, namely for the Dar Ceramica Center customer staff and for independent installers. architect@work, Rome Once again OLI will be present at architect@work, this time at the Rome edition. “Moon” black, the perfect flush plate OLI challenged Vista Alegre and "Moon black" was born! OLI in the emblematic hotel of Santiago de Compostela The Parador de Santiago - Hostal Reis Católicos, one of the most luxurious and historic hotels in Santiago de Compostela, has OLI products! OLI focuses on international training As a global brand, OLI aims to invest in knowledge and training in all geographies where the brand is present. At Israel's main train station Israel's main railway station - the Tel Aviv Savidor Main Train Station – chose OLI to equip its sanitary facilities. These were equipped with "OLI 80 Sanitarblock pneumatic in-wall cisterns and "Trend" control plates. We should note that this is the second Israeli public building to be equipped with OLI solutions, following the Tel Aviv Sourasky Medical Centre. “Glassy” available in new finishes "Glassy" flush plate, winner of the "Good Design" award, is now available with new finishes: Taupe, Gold, Anthracite, Red, Black and White. With this wide range of colours, "Glassy" is the perfect choice for any bathroom environment, conferring timelessness and elegance to the bathroom. Novelties at the BIG 5 OLI will participate in the BIG 5 trade fair in Dubai, which runs from November 26th-29th. The BIG 5 is the largest and most important trade fair in the Middle East for the construction industry. OLI will present the latest innovations, including the "QR Total Black", a sanitary module with high technology incorporated, that transforms the bathroom into a modern, functional and sustainable space. July was a busy month for OLI! OLI products in luxury hotel in Cuba The new five-star Gran Hotel Manzana Kempinski La Habana in Cuba has selected "OLI74 Plus Sanitarblock" concealed cisterns... Concealed cistern with two inlet valves The new "OLI74 Plus 2 inlet valve" flushing cistern has two water supply valves and is an important step for water sustainability... OLI reinforces connection to Architecture OLI debuted at Archi Summit, the largest architecture event in Portugal, bringing together 1,500 architects... OLI Annual get-together On July 6th OLI hosted their annual company get together. It was a fun afternoon filled with good food, music and laughter! Winning over Asia OLI´s patented sanitary system technology is winning over Asia, a leading geography in innovation and particularly attentive... Bronze, gold or soft-touch grey are some of the new finishes of the "Globe" concealed cistern flush plate. Making a splash in the USA OLI showcased innovative solutions in New York at the ICFF trade show that brought together architects and designers from around the world... OLI in the Apple Building The Apple building in Israel, which houses the second largest research and development centre in the world for the North American brand, has been equipped with innovative OLI solutions. OLI STRENGTHENS PRESENCE IN ISRAEL As part of the international training plan, OLI recently promoted a “roadshow training” program in Israel and Palestine, markets where OLI has strengthened its presence. NEW MOULD FACTORY INAUGURATED HIGHLIGHTS The Portuguese Minister of the Economy, Manuel Caldeira Cabral inaugurated OLI's new mould factory at the group's industrial complex in Aveiro on May 11th. HOSPITAL IN ISRAEL CHOOSES OLI Meir Hospital, considered one of the best hospitals in Israel, has selected OLI to equip its bathrooms. The products chosen are the concealed cistern OLI80 Sanitarblock and the "Trend" flush plate, as they guarantee excellent quality and functionality. OLI AT URBAN REHABILITATION WEEK In order to share their know-how and expertise in rehabilitation, OLI participated in the Urban Rehabilitation Week, at Pátio da Galé, Lisbon, from April 9th-15th. NEW CUSTOMERS IN RUSSIA More than 400 visitors, including designers, architects, builders, distributors and installers, were present at OLI's stand at MosBuild trade fair, from April 3rd-6th in Moscow, Russia. SPACE&INTERIORS OLI participates for the third consecutive year in space & interiors, the event in which architecture connects to the Milan Furniture Fair. OLI IN GERMANY TO PRESENT INNOVATIONS From March 6th to the 9th OLI will participate in the SHK fair in Essen, Germany, and will present the latest innovations. 2018: YEAR TO SAVE WATER Adopting the motto "New year, new life" OLI challenges everyone to reduce water consumption in the bathroom and to make a commitment to preserve water. REHABILITATE TO SAVE Urban Rehabilitation is a strategic imperative for OLI, who has developed solutions for bathroom remodelling that not only are sustainable, but also suitable for quick renovations. OLI WILL SPONSOR “LUXURY ITALIAN CONTRACT STYLE” BY SIMONE MICHELI AND PARTNERS FOR SOUTH KOREA. OLI will sponsor "Luxury Italian Contract Style" by Simone Micheli and partners for South Korea. Presentation in Dubai Growing significantly in the Middle East, OLI was at the Kempinski Hotel in Dubai, together with their client Al Taiboun, to present the latest sustainable solutions to brand representatives, distributors, engineers and architects from Iraq. Jeddah's Sail Tower with OLI One of the largest buildings in Saudi Arabia, Jeddah's Sail Tower in the city of Jeddah, has selected OLI solutions for the bathrooms. SOLIDARITY CONCERT INSPIRED BY WATER Solidarity Concert Inspired by Water was a huge success! OLI raised 6 thousand euros for the Firefighters in Aveiro. OLI RECEIVES AWARD FOR INNOVATION OLI was awarded the Millennium Horizons Award in the category "Innovation - Large Companies" at a ceremony presided over by the prime minister, António Costa, on November 15. ARCHITECT@WORK LONDON EDITION OLI will be present at architect@work London edition, the premier event for architects and designers that will take place from the 24th to the 25th of January at the Olympia London National Hall. Many are the women who daily write the history of OLI, so International Women's Day (March 8th) was marked... GERMAN FAIR APPLAUDS OLI INNOVATIONS The German city of Essen was the stage for SHK, one of the world's most important bath, building and energy fairs in the world, which applauded OLI's innovations. OLI AWARDS THE BEST WATER-SAVING IDEAS To celebrate World Water Day (March 22nd), OLI launched a contest of water-saving ideas on social networks that ran until March 23rd. 100% hygiene without complications Profound hygiene has become simple with "OLIPure", an internal storage system that releases liquid disinfectant with every flush of water in the toilet. OLI equips Hotel Torel Avantgarde Hotel Torel Avantgarde , the newest five-star hotel in the city of Porto, has chosen "OLI74 Plus" concealed cisterns and "Oceania Mia" control plates for their bathrooms. SOLIDARITY CONCERT On December 19th at 9pm, OLI will host the Solidarity Concert Inspired by Water at the Teatro Aveirense. Architect @ Work, Milan OLI participated in the international Architect @ Work fair, which took place from the 29th to the 30th of November in Milan. OLI AT THE NEW CRUISE TERMINAL The new Lisbon cruise terminal, in Jardim do Tabaco in the Santa ApolÃ³nia area, has selected OLI solutions for the rainwater drainage system and the bathrooms. CLOSER TO ARCHITECTURE In October OLI debuted at Architect@Work in Rome, one of the most important international architectural fairs, where OLI presented the latest solutions for sanitary ware for architects and designers from around the world. OLI TRAINING CENTRE WELCOMES INSTALLERS FROM AROUND THE WORLD Continuous training and proximity to industry professionals and the community characterize OLI's performance. NEW AND IMPROVED CONCEALED CISTERN OLI takes another step towards reducing water consumption in the WC by presenting concealed cisterns with various flushing volume levels. DID YOU KNOW OLI HAS A DIGITAL LIBRARY? OLI is committed to digital innovation and offers a BIM (Building Information Modelling) library. OLI plans to progressively expand their library and to continue to offer customers a wide range of Sanitary System solutions. ARCHITECT@WORK FAIR From the 11th to the 12th of October OLI will participate in the architect@work fair in Rome, Italy. THREE NEW VIDEOS OLI recently launched three new videos that make installing mechanisms in ceramic cisterns easy as pie. OLI is committed to digital innovation and offers a BIM (Building Information Modelling) library with a vast range of sanitary system... OLI WISHES YOU A GREAT VACATION After seven months of hard work in which OLI presented new solutions and intensified its international presence... OLI aims to provide customers with quality service as well as installation advice and training. OLI SUPPORTS RONALD MCDONALD FAMILY ROOM OLI contributed to the first Ronald McDonald Family Room in Portugal in Santa Maria Hospital in Lisbon. ROADSHOW IN ISRAEL AND PALESTINE As part of the international training plan, OLI has recently launched a roadshow in Israel and Palestine, where we have intensified our presence in recent years. As part of "World Environment Day", OLI joined Renault Cacia in organizing a lecture and awareness-raising exhibition on environmentally responsible behaviour. OLI – SISTEMAS SANITÁRIOS, S.A. IS THE NEW NAME Oliveira & Irmão, S.A. has changed its name to OLI - Sistemas Sanitários, S.A.. OLI IS GOING SOCIAL OLI is now present on three social networking sites and we look forward to connecting with you! LUXURIOUS CHILEAN WINERY CHOSE OLI The exclusive Vik winery, which produces the second best Chilean wine (La Cav 2015), chose OLI for its luxury hotel, Viña Vik Millahue. OLI AT THE SHERATON ALGARVE The Sheraton Algarve Hotel, integrated in the Pine Cliffs Resort in Albufeira, Algarve, has been renovated and has chosen OLI for the bathrooms. As of this month, OLI has an official page on Facebook. Like our page and keep up to date with the latest news. Follow us and share our publications! “MIES VAN DER ROHE” AWARD Portugal has four projects in the finalist stage of the "Mies van der Rohe 2017 Awards". This is one of the most influential architectural awards in the world. Of the four projects, OLI products are present in two of them - EDP's headquarters and the Nadir Afonso Museum. GREEN PROJECTS AWARDS The Green Project Award distinguishes, across seven categories, the most innovative projects in the area of sustainability in Portugal. Azor Range Was Updated The range of "Azor" inlet valves has been improved. HOTEL VIÑA VIK, CHILE OLI is proud to be selected for a construction project of exceptional quality. HOTEL VINAVIK, Chile TAILORED TO YOUR CREATIVITY The catalogue, Tailored to your creativity is now available. SANITARY SYSTEMS GENERAL CATALOGUE 2017 The catalogue, Sanitary Systems 2017 is now available. MAKING OF OLI OLI has teamed up some employees and hosted a photoshoot (Inspired in world famous paintings) to be included in the new 2017 agenda and calendar. OLI SELECTED FOR A HOSPITAL IN TEL AVIV The Ichilov Medical Center Hospital in Tel Aviv, Israel, has selected the "OLI74 Sanitarblock" concealed cisterns and "Electra III"... OLI WITH LXFACTORY To celebrate World Toilet Day (November 19), OLI challenged 16 artists to turn OLI cisterns into works of art. TRIBUTE TO THE OLI HEROINES Tribute to the OLI heroines. It´s impossible not to notice or be indifferent to the new mural that lines the building of our showroom. ARCHIPRODUCTS DESIGN AWARDS 2016 OLI has just been awarded the prize for "Archiproducts Design Awards 2016" - one of the most prestigious awards of Architecture... OLI EQUIPS THE AMAZON DISCOVERY HOTEL BOAT OLI was chosen to equip the washrooms in the "Amazon Discovery", a boat hotel in Peru. WORLD WATER DAY 2016 HIGHLIGHTS OLI celebrated yet another World Water Day. OLI PRODUCTS AT THE BAYAT TOWERS OLI was selected to equip the luxury development "Bayat Towers" in Jeddah, Saudi Arabia. OLI AT THE ABADE PEDROSA MUSEUM OLI is present in the first phase of the requalification of the Abade Pedrosa Museum, in Santo Tirso, with the "Trumpet" control plate, designed by the prestigious architect Siza Vieira. OLI IS GROWING IN EASTERN EUROPE OLI is growing in the Eastern European Market. In the last year and half, OLI has equipped several projects in Estonia (mostly in the capital Tallin). OLI AT THE SHERATON ALGARVE LUXURY COLLECTION HOTEL OLI is proud to yet again be selected for a construction project of exceptional quality. MERRY CHRISTMAS AND A FANTASTIC 2016! OLI wishes its team, partners and friends a Merry Christmas and a fantastic 2016! THREE DAYS TO RAISE AWARENESS OLI organized the World Toilet Day between the 19th and 21st of November. OLI wins Innovation Award OLI won the "Innovation Award" at the second edition of the "Litoral Awards". OLI AT BIG5 OLI will be present at BIG5, the International Building & Construction Show from the 23rd to the26th of November (between 11:00 – 19:00) at the Dubai World Trade Center in UAE. OLI OPEN WEEK VERY POSITIVE OLI Open Week 2015, held from the 10th to the 17th of October, was head of the Commercial Department, very positive. OLI IN FIVE AWARDED PROJECTS OLI is delighted to be part of five projects awarded in the “Construir Awards 2015”. CLASSY OLIFILO OLI recently launched a specialized collection for "Pavement Shower systems", which includes six different models in the OLIFILO range that meet all the needs in new or remodeled homes or hotel units. GOLDEN TOWER WITH OLI80 The building with the most anticipated opening inJeddah,Saudi Arabia, has OLI products. The “GoldenTower”, a high-end residential development will open in 2016 with the in-wall cistern OLI 80, Slim and River control plates, and the sanitarblock frame for bidets. NEW PESTANA HOTEL - ALGARVE OLI is proud to be selected for a construction project of exceptional quality. TRUMPET WORKSHOP OLI in partnership with the Siza Vieira architecture firm, hosted last Friday a workshop whose main focus was the Trumpet control plate. OLI PRESENTS NEW SIS CATALOGUE At an event held at the Olissippo Oriente Hotel in Lisbon, OLI presented the new Sanitary Installation Systems (SIS) catalogue. OLI EQUIPS NEW EDP HEADQUARTERS OLI was chosen to equip the new EDP headquarters in Lisbon. OLI AT THE DUBAI WORLD TRADE CENTER OLI will equip the Dubai World Trade Center, the largest UAE business complex which. HYDROBOOST WINS AWARD OLI won the “Best Equipment” award with the “Hydroboost” system, in the "Bathrooms, Accessories and Equipment" category at the “2015 Innovation in Construction Awards””, which is organized annually by the “Construir” newspaper and “Anteprojectos” magazine. OLI SMART FLUSH - ISH OLI surprises again at the ISH fair in Frankfurt, Germany, with the presentation of "OLI Smart Flush", a multifunctional system that based on the users needs selects and activates the appropriate flush volume (solid - full flush, liquid - half flush). OLI WINS GOOD DESIGN AWARD OLI has won the Good Design Award, the oldest and most prestigious International Design Award, organized by the Museum of Modern Art in New York and The Chicago Athenaeum. THE CONCERNS OF OLI IN PORTUGUESE PRESS The CEO of OLI, eng. António Oliveira, demonstrates concern at the lack of alternative to road transport... OLI PRESENTS THE PERFECT IN-WALL CISTERN The perfect in-wall cistern is presented at the prestigious ISH fair in Frankfurt, Germany. OLI IN JOB FAIR UA OLI was present at the Job Fair held in the rectory building of the University of Aveiro. The event was news in several media, among them the Diário de Aveiro. OLI AT TORRE DOS CLÉRIGOS OLI is part of the renovated Torre dos Clérigos, one of the most iconic and popular "symbols" of Porto, in Portugal. OLI120 PLUS AT OLI OPEN WEEK 2015 The in-wall cistern OLI120 Plus was presented at the OLI Open Week 2015. OLI’S THE BEST COMPANY OLI was considered the Best Company inPortugal in the "Bathrooms, Accessories and Equipment" category at the “2015 Innovation in Construction Awards”. OLI AT DOURO PALACE HOTEL OLI is part of the renovated Douro Palace Hotel Resort & Spa at Baião, with Slim and Trend Control Plates. FIVE PROJECTS AWARDED IN THE PRESS OLI is part of five projects awarded in the “Construir Awards 2015” and that achievement was highlighed in portuguese media OLI WORLDWIDE RELEASE On the opening day of the prestigious ISH fair in Frankfurt,Germany, OLI (Stand A55, Hall 4.0)Â does the worldwide release of yet another innovative product in the context of sustainability. OLI CONTROL PLATE IN RADIANCE OLI was chosen to equip, with the IPlate control plate, the "Radiance", a luxury real estate with 119 apartments, located in a privileged area of the Sydney bay, in Australia. OLI AT ISH From the 14th to the 18th of March, OLI will present many products at the ISH fair in Frankfurt. Come visit us in Hall 4, level 0, booth A05 and discover what we have for you. WORLD WATER DAY - FLASHMOB World Water Day was celebrated by OLI in Aveiro OLI CELEBRATES WORLD WATER DAY World Water Day (22 March) was celebrated by OLI in Aveiro. OLI IN THE “OBSERVADOR” The “Observador” reported OLI´s investment of half a million Euros in internal testing facilities. “JORNAL DE NEGÓCIOS” INTERVIEW The CEO of OLI, eng. António Oliveira, gave last week an interview to “Jornal de Negócios”... This website uses cookies in order to optimize its operation and personalize the service to offer you a better browsing experience. Disabling cookies in your browser may imply that certain content on our site does not function properly. Not deactivating cookies and continuing to navigate this website means you accept their use and our "Privacy Policy". Once you have accepted this notice, it will not appear again during your browsing session on this website. 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__label__cc	0.673615	0.326385	Overparenting in Academics is Not the Answer By Melissa Bykofsky When I was getting ready to go away to college, there were a lot of things my parents had to prepare me for. I was ready for the classes, the tests, and the extracurricular activities, but what about everything else? I had to learn how to do laundry, clean, pay bills, and cook (note: I once managed to set Easy Mac on fire)...#sendhelp! My parents included a happy balance of control and freedom into my upbringing: They made my bed when I forgot to, washed my dishes when I "accidentally" left them in the sink, and separated my whites and colors before they did my laundry, but I was expected to figure out plenty of life on my own, too. It turns out my parents decision to take a more hands-off approach when it came to overseeing my school work (they sat with me when I completed homework growing up, but always made it clear that doing well in school was encouraged, but generally my decision, and an A- was not failure) may have led to my later success in college and grad school. In Julie Lythcott-Haims' book, How To Raise An Adult: Break Free of the Overparenting Trap and Prepare Your Kid For Success she points to overparenting as a cause for the growing number of psychological problems college students are facing today. "The data emerging about the mental health of our kids only confirms the harm done by asking so little of them when it comes to life skills yet so much of them when it comes to adhering to the academic plans we've made for them," she writes. Within the book, Lythcott-Haims quotes Madeline Levine, a psychologist and author of The Price of Privilege, who points to three ways parents are unknowingly causing psychological harm: When we do for our kids what they can already do for themselves; When we do for our kids what they can almost do for themselves; and When our parenting behavior is motivated by our own egos. Levine says that this is how parents "deprive our kids of the opportunity to be creative, to problem solve, to develop coping skills, to build resilience, to figure out what makes them happy, to figure out who they are." In the news lately, I've been reading stories of parents on the other end of the spectrum, those considered "free-range." In Maryland, a couple was investigated by authorities and Child Protective Services when their two children, ages 6 and 10, were found at a park without adult supervision. Providing young children with complete freedom like this is not necessarily a solution, but neither is shadowing or controlling their every move. When her study results came in, Lythcott-Haims learned "that figuring out for themselves is a critical element to people's mental health. Your kids have to be there for themselves." As a kid I learned how to be independent at sleep-away camp when I was going into 4th-grade; I was encouraged to sign up for extracurricular activities I was absolutely horrible at (thanks for those participation trophies, softball!); and I was taught to ask my own questions when it came to concerns over assignments or grades. I still call my parents every day with questions about work, relationships, and standard crises most 20-somethings have, but I also know how to be there for myself. Melissa Bykofsky is the associate articles editor at Parents who covers millennial trends, entertainment, and pop-culture. Follow her on Twitter @mbykofsky.	cc/2020-05/en_middle_0111.json.gz/line2902
__label__cc	0.560526	0.439474	Sheila Chavez Kim McBurrows Secret Settlements – Our Stand Patrick Malone & Associates Offers Scholarship to Law Students for Representing Real People Patrick Malone Daniel C. Scalpi Alfred Clarke Aaron M. 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Bike Map Commute Risk Calculator Patient Safety Blog ProtectPatientsBlog.com Malpractice A-Z Patrick Malone Law Medical Malpractice & Personal Injury Law Firm \| Patrick Malone Law Research your injury rights Are You A Lawyer Seeking Co-Counsel ? Give a lasting holiday gift of health: Volunteer for a medical research study Clinical trials can benefit volunteers Risks? Informed consent is critical Improving a key component of modern health care Estimated number of diseases, for which experts say only 500 treatments or effective means of management currently exist. Number of clinical studies now listed with U.S. National Institutes of Health in 50 states and 194 nations. Percentage of 106,000 individuals who report ‘no conditions’ (they are healthy) and who have volunteered to participate in medical research through a major nonprofit organization. That toy the kids whined about for weeks may be broken hours after emerging from the box. The gift card you gave will be frittered away, probably on junk. That adorable new pet adorned with a bow? It may be a pain in the parents’ anatomy by the new year. If you’re like millions of Americans, you want this festive holiday season to also have higher meaning, especially when it comes to sharing things of value. So here’s some “out-of-the-box” thinking. Consider giving a unique gift of health by participating in medical research. This volunteerism can be done by young and old, the well and the sick. It may benefit you in many ways: You will know you helped others in a special way. You may assist in advancing new treatments. You also may get extra medical attention, even access to therapies unavailable to the public. Just by joining a clinical study, you will gain insights into a critical component of contemporary medicine. And you will learn more about a vital element in your health care—your right to informed consent. Participating in medical research has risks. It requires a commitment not made lightly. Don’t let your eyes go all aglow at the prospect. Keep them and your mind wide open as you unwrap a distinctive way to help others. And read on. The dramatic headlines almost daily detail medical-scientific progress, including: New treatments based on patients’ genes, cancer drugs that get the body’s own systems to attack disease, vaccines being developed for viral infections like Zika and HIV-AIDS, and improved ways to avert heart disease. Look closely at any of these, and they share something fundamental: They require human testing, medical research conducted in rigorous, tightly supervised, and ethical fashion in what broadly are termed clinical trials. These occur, as the figure above shows, relatively late in what can be a long scientific process. Only after experts have labored long in labs, in research and development (R&D) and especially with animal studies, do they progress to clinical, interventional, or observational studies with slowly increasing numbers of human subjects. In these studies, investigators may seek to understand how a disease runs its course, how to prevent or test for it, as well as how best to diagnose and treat it. The research may determine patients’ quality of life with drugs, devices, or treatments. Health professionals (doctors, nurses, and Ph.Ds.) conduct these studies, backed by research institutions (including medical schools and universities), the federal government, and businesses (drug or device makers). It often occurs at universities and academic medical centers, because this kind of study can be costly, time- and resource-intensive. It adds to institutional prestige—and potentially profits. The Washington, D.C.-area is rich with clinical trial sites, including top hospitals, elite academic medical centers, and the various institutes of the National Institutes of Health (NIH) in Bethesda. That could make your role in medical research easier and more convenient. Types of clinical trials In interventional studies, Uncle Sam notes, patients may be treated with: “Medical products, such as drugs or devices; procedures; or changes to participants’ behavior, such as diet. [These] trials may compare a new medical approach to a standard one that is already available, to a placebo that contains no active ingredients, or to no intervention. Some … compare interventions that are already available to each other. When a new product or approach is being studied, it is not usually known whether it will be helpful, harmful, or no different than available alternatives (including no intervention). The investigators try to determine the safety and efficacy of the intervention by measuring certain outcomes in the participants.” In contrast, in observational studies, experts “assess health outcomes in groups of participants according to a research plan or protocol. Participants may receive interventions (which can include medical products such as drugs or devices) or procedures as part of their routine medical care, but participants are not assigned to specific interventions by the investigator (as in a clinical trial).” Observational research can involve following and recording data on large groups of subjects over extensive time. This is how the decades-long Framingham heart study led experts to emphasize exercise, diet, and other factors like stress-reduction in preventing coronary disease. Participants in clinical studies must meet stringent requirements to qualify. Researchers value highly specialized subjects, including those with certain illnesses, past or present. It’s misunderstood that clinical studies only involve the sick or those with close relatives with specific diseases or conditions. Studies are planned in phases (see figure above). Early on, in Phase One and even Phase Two, researchers may want younger, healthier subjects to get baseline, control data. Children, veterans, and seniors also are welcome participants, enrolling under strict protections. Study volunteers can benefit. They can get the satisfaction of knowing their participation helps others and may advance medicine. They often receive some compensation for their time and trouble. Besides their regular care—and anyone considering clinical trials should consult their personal physician—they may receive added medical attention. They may undergo intensive exams to assess their qualification for or status during trials. If seasonal allergies, say, seem to tee you up for a test of prescription drops to help ease watery, hay fever-inflamed eyes, you may also undergo at no charge a fuller battery of expensive allergy tests. If you’re about to be a control subject for a new blood pressure medication, you might get a complete, no-cost physical. More important, in later stage trials, patients with chronic or serious illness may receive novel or innovative drugs or treatments not yet available to the public. The costs of this therapy may be partially or fully covered by trial sponsors and participating research institutions. Some gravely ill cancer patients have enrolled in trials and received drugs costing more than $100,000 a year—and that made huge differences in their health. But the effectiveness of experimental drugs may not last or they may require them for longer than is covered in a clinical trial. All research outcomes aren’t optimal and cheery. Volunteers must understand this from the start. You’re upset after learning that a loved one is afflicted with a disease with few favorable treatments. You’re healthy and decide you want to do something to prevent this from happening to anyone else. Or maybe you discover that your family has a predisposition (like the BRCA gene mutation for cancer, for instance), and, though it hasn’t hit you yet, you want to assist investigators in attacking it before it does. Or you may have cancer, heart disease, or other conditions, and you have decided, at some stage in your illness, that you want to help others. No matter the motivation, when you choose to enroll in a clinical trial you will be a volunteer. And among the few. Although opinion polls show they’re admired for doing so, only a small percentage of Americans participate in clinical trials. Fewer than 5 percent of cancer patients participate in them. Many studies get canceled due to lack of subjects. Uncle Sam is making a big push to get more, now under-represented women and people of color into studies. If you decide you want to be included, you quickly will learn that investigators, mindful that the mere mention of human experimentation sends shivers down the spines of some, will provide you with abundant information about your prospective role. This isn’t a mere formality. Laws require investigators to detail for you answers to dozens of questions about a clinical trial, including who will run it, who will benefit from it, as well as its goals, methods, duration, demands (time and travel), potential costs to you, and, most critically, your possible health benefits and harms. Who oversees patient safety? What kind of protections will you have during and after the trial? Will drugs or treatments have side effects, and will these be lasting? The voluminous flow of information starts at the beginning of the process—it gets prominent display in online resources about medical studies and signing up to be considered for them (see below). If you’re healthy and raring to go, this may be patience testing; if you’re sick and possibly failing, it may seem excruciating. Modern medical science, though, is haunted still by the horrors of cruel exploitation of human subjects. It wasn’t that long ago that sadists from the Axis powers conducted heinous human experiments. It was only in 1997 that President Clinton formally apologized to victims of federally subsidized experiments in Tuskegee, Ala., on African American syphilis patients in the 1930s (in which doctors deliberately withheld curative drugs from patients to observe the effects of late-stage syphilis). It was only in 2010, after Rebecca Skloot wrote her nonfiction best-seller, that the nation learned the sad saga of Henrietta Lacks. She was a poor African American mother of five who died in 1951 at Johns Hopkins in Baltimore of an aggressive cancer—but not before her cells were harvested. Neither Lacks nor her family knew about or benefited from years of researchers’ cultivation of the “immortal” HeLa (cryptically named for her) experimental strain of cells, which paved the way for advances in chemotherapy, the polio vaccine, and in vitro fertilization. Patient involvement and transparency have become a major aspect of medical research. And this includes a critical affirmation of one of your basic, vital patient rights: informed consent. This isn’t something that gets handled with a lot of signatures and initials on piles of paperwork. It is the duty of anyone who provides you any kind of medical treatment. Informed consent expresses a concept at the core of any free society: Each person has a right to decide what to do with his or her own body, as long as you don’t hurt someone else. That includes medical care. But this is a right that many scared people are quick to give up. They want to surrender decisions to doctors, not realizing two critical facts: Doctors may have very different values. They may not, for example, put as much emphasis on whether a surgery disfigures the body if it offers a slightly higher chance of a patient’s living some uncertain additional amount of time. Doctors also may have conflicts of interest that make it hard to give objective advice. For example, they may make a lot of money if you opt for their surgery and no money at all if you make a different choice. Because MDs are just as flawed and imperfect as everyone else but know a lot more medical facts than most lay people, the law and medical ethics place a simple duty on every doctor: Give patients the important facts so they can make intelligent decisions about what treatment to have and where to get it. That’s why informed comes before consent. Information comes first. Consent is meaningless without the facts. Informed consent is really about building a bond between doctor and patient through a candid dialog that doesn’t leave out anything important. Patients, medical ethicists say, want to make a leap of trust with professional caregivers. But trust is built on honest information. It’s not a leap of blind faith. This is especially true in clinical trials, where participation is voluntary. IRBs, single- and double-blind studies, and placebos At research sites, special panels known as Institutional Review Boards (IRBs) oversee clinical studies to ensure they are ethical and to protect participants’ rights and welfare. These doctors, researchers, and community members legally must ensure that research risks are minimized and are reasonable in relation to any potential benefits. IRBs can prod investigators to clarify—especially if you or your loved one is in the late-stage of an illness and hoping to join research under way—whether a study is single- or double-blind and involves a placebo. In double-blind studies, neither patients nor caregivers know who is or isn’t receiving a drug or treatment under research. In single-blind trials, a pharmacist might know who gets an inert alternative or the test treatment, but patients must go to a special site to get drugs from her. In many trials for drugs for late-stage diseases, patients needn’t fear they will get just a placebo. Many studies, instead, compare existing drugs that are treatment standards against new medications. There also may be compassion exemptions so that more patients than not receive a medication under scrutiny, particularly if it shows promise; trials also may be suspended or halted if it becomes clear that hoped-for outcomes aren’t occurring or patients are suffering bad side effects, even dying. Investigators legally must report what are known as adverse events or serious adverse events that occur to subjects in trials. Because many volunteers may get drugs or treatments, they can suffer the same harms as occur in medical practice: Some powerful drugs may be toxic and have side-effects that make them ill. They may have reactions to medications, even inert or placebo drugs. They may be injured when receiving injections or IVs. They may develop other illnesses or complications during and even after a study, and these must be reported, even if they are only suspicious and not directly tied to a trial. Some studies, particularly of late-stage drugs or treatments, are halted when patients die. International attention focused on such a recent incident in France, where six subjects in a drug trial were hospitalized, with one pronounced brain dead. It also should be underscored that patients can withdraw at any time from a clinical trial, and they should be told how. Scientific advances also may force researchers and patients alike to confront tough issues about who benefits from medical research, especially clinical trials. Many innovative therapies now target diseases’ genetic or molecular structures. To conduct robust investigations in these areas, researchers must collect bigger amounts of patient tissues and data. These both are going into huge banks and databases. But who owns the material or medical byproducts? If you have a gene sequence that offers protections from a disease or condition, is it yours, or does it “belong” to researchers who found it and a way to turn it into a therapy? And for how long? If your blood or tissue was routinely collected as part of a trial, is it anonymized to protect your privacy, and if it is later found to have value, must researchers let you know? Idealism and profit potential To be sure, the idealistic wish to heal the sick and cure diseases drives and sustains many fine doctors, nurses, and Ph.Ds, as well as universities, academic medical centers, and hospitals where they labor. But health care is a big business with huge financial stakes. Institutions gain a giant reputation boost and competitive advantage by being leaders in medical-scientific research. Drug development, via clinical trials, can lead to major profits. Although many medical studies seek to and eventually produce modest advances, some research can be likened to oil wildcatting—and many institutions of note not only are out there digging, they have intellectual property teams ready to reap riches from the rare gusher. In 2014, just 15 major American universities produced 70 percent of all revenues among their peers from patent-license royalties. New York University got $650 million in such payments for the rheumatoid arthritis drug Remicade. Emory University received $525 million in royalties for Emtriva, an HIV drug. The University of California at Los Angeles has signed a deal for $520 million for Xtandi, a prostate cancer treatment. And Northwestern University says that as much as 18 percent of its $18 billion endowment, the eighth largest in the country, can be traced to pioneering work in campus labs that resulted in Lyrica, a hot-selling, non-opioid prescription drug to treat nerve pain and seizures. Here’s hoping that you’re blessed with great holidays, and if you choose to give your time to enroll in a clinical trial, that it helps you, your loved ones, and all of us with some significant health benefits! Intrigued? If you want to learn more about enrolling in a clinical trial, talk to your own doctor first. She may be able to offer counsel on suitable choices. If you’re volunteering because you want to help a friend or loved one, you may want to talk with them and their health professionals to see if they have insights about appropriate research opportunities for you. Advocacy or support groups for specific illnesses or conditions also may offer productive ideas. Uncle Sam has important resources you can tap, starting with the web site clinicaltrials.gov, which can be accessed here. This is one of the major registries of trials, and officials have sought to provide abundant information about research studies, participating in them, and other pertinent resources available through this site. The search engine allows volunteers to search a database of more than 230,000 trials around the world. Type in “healthy volunteer,” if that fits you, and many options will pop up. Alas, the trial abstracts are replete with medical and scientific jargon and may not be the easiest for lay people to figure out. Researchers are still grappling with this issue. It is invaluable, though, for prospective trial participants to study thoroughly the available information, including from the federal Food and Drug Administration, about risks and benefits of trial enrollment. To assist, nonprofits also have stepped in. Prospective volunteers may, for example, want to click here to access the website of researchmatch.org, an organization that says it has more 100,000 volunteers who hope to assist more than 100 institutions in clinical trials. It also may be worth clicking here to check out the web site of the Center for Information and Study on Clinical Research Participation. It’s a nonprofit that says it even will conduct hand-searches to help volunteers find appropriate trials. The Washington, D.C., area is rich in medical research sites. The NIH web site on clinical trials can be accessed here, while the region’s many former service personnel may wish to access the U.S. Department of Veterans Affairs site for research information here. Meantime, Johns Hopkins and Georgetown are among the many teaching and academic medical centers and major hospitals in the region where many research initiatives also are under way. If you or your MD deal often with a major hospital that you both like and respect, check out the institutions’ web sites to see what clinical trials may be under way there that you might volunteer for. Improving a key component of modern health care Although volunteers play a crucial role in medical research, investigators struggle to recruit them. Few Americans participate in clinical trials. Doctors may need to step up their role in letting patients know about them. Ditto for advocacy groups that aim to help individuals with specific diseases. Uncle Sam, too, has come under fire for not doing more to assist. In response, the U.S. National Institutes of Health has tried to improve its major web site resource on clinical trials, boosting the information it provides, as well as aiming to simplify and clarify how users search for appropriate research projects. Hospitals, academic medical centers, and other research institutions have stepped up their communications about their trials. Full disclosure: Medical research is a field rife with its own controversies. Concerns are growing that trials may produce skewed results and fuel health disparities because the willing subjects lack sufficient gender, racial, and ethnic diversity. Critics, to their credit, point out that investigators have been too pokey under federal law about disclosing results, particularly when they’re bad. Volunteers are pressing researchers more—and good for them for doing so—to share not only their studies’ final results but also more of the health information they gather on patients during trials. Contrary to persistent, misleading media reports on health research, medical science advances slowly. You know now why care needs to be exercised in discussing trials in early phases, or in jumping to conclusions about research that differs because it is interventional versus observational (where associations are not causes). But the sometimes glacial pace at which health investigations proceed is an issue—both for the desperately ill (for example, those in past days with then-deadly HIV-AIDS) and for commercial interests like device makers and Big Pharma. The federal Food and Drug Administration, as the main regulator in this area, has taken the most heat and has tried to respond to criticisms, for example, with expedited drug reviews. Congress, even as this newsletter is written, is in the midst of a year’s work on a sprawling health measure with potentially significant effects on medical research. Stay tuned. HERE’S TO A HEALTHY 2016! Patrick Malone & Associates Auto, Truck & Motorcycle Accidents Accounting & Legal Malpractice The Lawsuit Process FAQs about injuries & the legal process Legal deadlines for your lawsuit What to expect from your “independent” medical examination Patient Safety Tips DC Hospital Rating Map Patient Safety Newsletter from Patrick Malone Books for Attorneys Expert Witness Resources Closing Arguments in Trial Medical Society Statements on Expert Witness Testimony Cross Examination Transcripts Client reviews on Patient Safety Blog by Patrick Malone & Associates Accessibility of Health Care PATRICK MALONE & ASSOCIATES, P.C. 1310 L Street NW Auto, Truck And Motorcycle Injuries Defective And Dangerous Products © 2020 Patrick Malone & Associates, P.C. \| All Rights Reserved \| Legal Notice	cc/2020-05/en_middle_0111.json.gz/line2906
__label__cc	0.664554	0.335446	Early Vs Delayed Cholecystectomy for Gallstone Pancreatitis Posted by Rebecca Rice \| Nov 14, 2019 Data indicate that gallstones are the most common cause of acute pancreatitis in the United States. While patients with gallstone pancreatitis (GSP) ultimately require cholecystectomy to prevent future pancreatitis, the optimal timing of this procedure remains unclear. Many institutions delay cholecystectomy for mild GSP until normalization of laboratory values and abdominal pain resolution based on the belief that early surgery may increase complications. However, previous single and dual institutional studies have shown that early cholecystectomy for mild pancreatitis appears to be associated with shorter length of stay, which can result in lower costs and better patient satisfaction, explains Ashkan Moazzez, MD, MPH. However, the relationship of early cholecystectomy with morbidity in this patient population has not been previously evaluated. For a study published in JAMA Surgery, Dr. Moazzez, Christian de Virgilio, MD, and colleagues compared data on patients with mild pancreatitis who had received cholecystectomy in less than 48 hours (early) from hospital admission with that of those who underwent the procedure in 48 hours or longer from hospital admission (delayed). Data was extracted from the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database for the years 2011-2014. “Our main findings were that early cholecystectomy in patients with mild gallstone pancreatitis was associated with shorter hospital stay and operative times, but not with higher morbidity or reoperation rates, when compared with delayed cholecystectomy,” says Dr. Moazzez. “While patients in the early cholecystectomy group were more likely to undergo the procedure laparoscopically, early cholecystectomy was associated with more biliary procedures, such as intraoperative cholangiogram and endoscopic retrograde cholangio-pancreatography.” Dr. Moazzez notes that a large, multi-institutional, randomized study is needed to hopefully confirm the study findings. In meantime, however, he says the findings “further reinforces the notion that early cholecystectomy can be safely performed for patients with mild gallstone pancreatitis and that there is no need to await complete resolution of symptoms or abnormal laboratory values.” Early vs Delayed Cholecystectomy for Mild Gallstone Pancreatitis https://jamanetwork.com/journals/jamasurgery/fullarticle/2696609 PreviousApple launches app to let users enroll in health studies NextThyroid Eye Disease Improves With IGF-R1 Inhibitor Rebecca Rice Christian de Virgilio, MD & Ashkan Moazzez, MD, MPH Christian de Virgilio, MD Chair, Department of Surgery Harbor-UCLA Medical Center Co-Chair, College of Applied Anatomy Professor of Surgery UCLA School of Medicine Christian Miguel de Virgilio, MD, has indicated to Physician’s Weekly that he has no financial interests to disclose. Ashkan Moazzez, MD, MPH Medical Director, Utilization Management UCLA David Geffen School of Medicine Ashkan Moazzez, MD, MPH, has indicated to Physician’s Weekly that he has no financial interests to disclose. Should Your Practice Consider Telehealth? A Look at Healthcare Expense Allocation Making the Case for Early ID Specialist Involvement Examining Attitudes Toward Pregnancy & Childbearing in Women Surgeons The Changing Tide of Knee Arthroscopy in the U.S. October 25, 2011 Maker Halts Distribution of Generic Zantac Due to Possible Carcinogen September 19, 2019 Nonalcoholic Fatty Liver Disease & Diabetes February 5, 2019	cc/2020-05/en_middle_0111.json.gz/line2911
__label__wiki	0.867215	0.867215	Women's Boxing Olympic Trials: Sakshi Chaudhary and Simranjit Kaur makes it to the qualifiers As the trials for Women's Boxing Olympic qualifiers came to an end today, Sakshi Chaudhary and Simranjit managed to secure a place in the Indian squad. Written By Pinkvilla Desk 201562 reads Mumbai Updated: December 30, 2019 07:04 pm It is a moment to celebrate for boxers Sakshi Chaudhary and Simranjit Kaur who have managed win the ongoing Women`s Boxing Olympic qualifiers trails today. To note, the trials were being held at the Indira Gandhi Stadium in the national capital and concluded on December 28. It was an interesting competition for both the boxers but they managed to register a win in their respective categories. While Simranjit defeated L Sarita Devi with 8-2 in the 60 kg category, Sakshi upstaged Sonia Lather with 9-1 in the 57 kg category. With this magnificent triumph in the trails, Sakshi and Simranjit have secured place in the Indian squad for the Asia/Oceania Olympic qualifiers. The qualifiers will be taking place in China in February 2020. Interestingly, Sakshi and Simranjit will be joining six-time world champion Mary Kom, Lovlina Borgohain and Pooja Rani in the squad. Mary, Lovlina and Pooja will be fighting in the 51 kg, 69 kg and 75 kg categories respectively. Certainly, a proud moment the young boxers and moment to pull up the socks for the upcoming qualifiers of Women's Boxing Olympic. Here is the complete Indian Women Boxing squad for upcoming Olympic Qualifier tournament (Feb 2020) scheduled in China: Mary Kom: 51 kg Sakshi Chaudhary: 57 kg Simranjit Kaur: 60 kg Lovlina Borgohain: 69 kg Pooja Rani: 75 kg — India_AllSports (@India_AllSports) December 28, 2019 Meanwhile, on the other hand, Mary Kom had also registered her win in the 51 kg respectively by defeating her fellow countrywoman Nikhat Zareen in an incredible summit showdown. The 36-year-old boxer, who holds the record of being the only women boxer to have won eight world championship medals, triumphed the trials by beating Zareen with a crushing 9-1 split decision and made it to the Indian team for 2020 Tokyo Olympic qualifiers. Credits :Twitter Women's Boxing Olympic Trials Sakshi Chaudhary Simranjit Kaur	cc/2020-05/en_middle_0111.json.gz/line2914
__label__cc	0.516815	0.483185	Local Leaders Press Massachusetts for New Sources of Transportation Funding November 16, 2019, 5am PST Three separate coalitions of local mayors, each from different corners of Eastern Massachusetts, want to the commonwealth to prioritize transportation funding. Some even called for a 15-cent increase to the gas tax. $900 Million in BUILD Transportation Grants Announced The U.S. Department of Transportation this week announced $900 million in BUILD grant funding for transportation projects around the country, supporting a similar focus on rural and highway projects as in previous rounds of spending. Engineering News-Record Election 2019: Planning and Development Related Results Roundup November 6, 2019, 11am PST Many states and cities around the country voted on November 5, 2019 to decide matters related to the future of the built environment. Rethinking Transportation Finance in Massachusetts Improving the systems and politics of transportation funding could ensure more local money, more efficient land use planning and mobility choices, and more. New for 2019: A Congressional Caucus for Public Transit October 16, 2019, 11am PDT A new congressional caucus has been formed under the assumption that federal transportation policy is regressive and discriminatory. WBZ News Radio Kentucky Gets 25% of the Transportation Secretary's Time When it comes to grants, one state has the attention of Transportation Secretary Elaine Chao above all others. New Priorities, Not More Money, Need to Reform Federal Transportation Policy October 4, 2019, 6am PDT Transportation for America, one of the leading advocacy organizations for multi-modal funding at the federal level, has announced a drastic change to its agenda. Transportation for America Trump Administration Suddenly Holding California to Higher Environmental Standards October 3, 2019, 10am PDT The U.S. Environmental Protection Agency wants to force the state of California to spend highway money on public transit, because of the environment. Eno Center for Transportation The First Highway Trust Fund Bailout September 11, 2019, 7am PDT September 9 marked the 60th anniversary of a defining moment in U.S. transportation history. $225 Million in Federal Funding for Rural Bridge and Highway Projects Announced The U.S. Department of Transportation this week announced the recipients of $225 million in project funding under the Competitive Highway Bridge Program. The program is reserved for projects located in mostly rural states. Voters Will Decide on $3.5 Billion Transit Funding Bond in Houston Houston's potential as a multi-modal city will be on the ballot this November. 6 Electric Buses Coming to Atlanta A federal grant puts Atlanta among the vanguard of cities introducing electric bus technology to the streets. Too Many Roads for Financial Sustainability Overpaving roads is like overeating ice cream, according to this Strong Towns article. Bill Would Spend Five Percent of All Federal Highway Grants on Complete Streets July 12, 2019, 6am PDT New federal legislation would establish a national complete streets program. Hyperloop for the Great Lakes Gets Initial Blessing the U.S House of Representatives July 1, 2019, 6am PDT The U.S. Senate still needs to approve the bill that would spend $5 million in initial funding for the Great Lakes Hyperloop System. Crain's Cleveland Business Little Support for Congestion Pricing in the D.C. Area May 18, 2019, 1pm PDT Just about no one in the D.C. regions wants to pay to alleviate traffic. Tolling on the Agenda for Connecticut Connecticut political leaders are heading toward a vote that would implement tolling on several of the state's highways to help fund transportation infrastructure projects around the state. How Much for Roads and Highways in a Proposed Portland-Area Transportation Funding Measure? A regional transportation tax could be on the 2020 ballot in Portland and surrounding communities in Oregon. How much of that money created by the new tax, should it pass, will go to transit and how much will go to cars is an open question. Analysis of U.S. DOT BUILD Grants Raises Critical Issues About Spending Priorities Transportation for America is crunching the numbers on how the Trump administration has shifted transportation funding programs since it took over the TIGER grant program and made it into the BUILD grant program. $1.5 Billion in BUILD Grants Funding for Transportation Projects Awarded The U.S. Department of Transportation has favored grant funding for rural communities under the Trump administration.	cc/2020-05/en_middle_0111.json.gz/line2917
__label__cc	0.640934	0.359066	Reader gets response (but no comfort) from Public Service Commission By Beth Kassab Orlando Sentinel Columnist \| Aug 28, 2012 \| 11:03 AM In a recent column about the Public Service Commission's soft-ball questioning of the new Progress Energy boss (Duke Energy CEO Jim Rogers), I encouraged fuming readers to write to the commission and make their outrage known. After all, it is the Public Service Commission and commissioners should be trying to please more than utility executives. At least one reader took me up on it. He wrote to commissioners and called Progress' recent $500,000 check to the Republican Party "unacceptable." "What gives this company the right to petition for rate increases when such a large amount of my and others' money is being used to fund political parties?" wrote Anthony Borka. "If I were a customer of WalMart and didn't like the store, I could go to Publix. But as a customer of Progress can I go to FPL or OUC? No, I can not," he wrote. The next day Borka received a response -- not from any of the commissioners themselves, but presumably from the staff member assigned to handle such pesky complaints from the public. Mark Futrell, director of the office of industry development and market analysis, attempted to calm Borka's concerns this way: "The political contributions made by Progress Energy Inc. (now Duke Energy) are paid for by the shareholders of the holding company." President Trump is unpresidential, but he just can’t help himself \| Commentary Also remember the white people who helped Dr. King \| Letters Sheriffs swear an oath to uphold the entire Constitution, not just the parts they like \| Editorial "Progress Energy Florida is the regulated electric utility which is an affiliate of Duke Energy. The electric rates of Progress Energy Florida are designed to only pay for the cost of providing electric service to its customers." Oh, I see. So the money is separate. Somehow we're supposed to be comforted that our power bills aren't going to line politicians' pockets because there is some kind of mythical wall between shareholder dollars and ratepayer dollars. That may be accurate on the accounting ledger, but we all know the practical truth. The shareholders have so much money to throw around to political causes because the ratepayers are continuously asked to pay more. More for base rates. More for building projects and new power sources. If Progress Energy and other utilities had to go to Wall Street to raise money for their capital costs like other companies, than perhaps shareholders wouldn't feel quite so generous with their political largess. Progress Energy Incorporated Civil and Public Service Duke Energy Corporation Most Read • Opinion Once again, Tribune wants veteran journalists to leave. Here’s why we haven’t ... yet. \| Commentary	cc/2020-05/en_middle_0111.json.gz/line2923
__label__cc	0.637534	0.362466	Hugh Grant ties the knot with Anna Eberstein The actor, who has claimed to not believe in marriage, has three children with his long-term lady. Actor Hugh Grant, 57, bit the bullet last weekend and married his girlfriend of six years, and the mother of three (of his five) children, Anna Eberstein, 39, in London. A post shared by Lovely's Vintage Emporium (@lovelysvintage) on May 27, 2018 at 4:12pm PDT The couple tied the knot at Chelsea registry office, close to their West London home, in front of close family members. They have three children together, while Grant also has two children from a previous relationship. This marriage is the first for the Notting Hill actor, who previously expressed that he doesn’t believe in marriage, as it is “unromantic” to commit to the same person for many years. A post shared by Chi Magazine (@chimagazineit) on May 27, 2018 at 5:03am PDT The bride wore a vintage Chanel skirt and a blue shirt, while the groom wore a dark navy suit for the occasion. Wishing this couple a married life filled with romance (and other things)! A post shared by Peeping Moon (@peepingmoon) on May 26, 2018 at 6:22am PDT Lovely's Vintage Emporium / Instagram Baby on board! Ashley Graham & Justin Ervin welcomed their first child together “Thank you for your love and support” Revealed! Baby Archie’s godparents are known and they’re not who anyone expected Prince Harry and Meghan Markle made touching choices WATCH: Prince Harry speaks out about his &Meghan Markle’s “royal exit” “It brings me great sadness that it has come to this.” Brad Pitt’s reaction to Jennifer Aniston’s SAG Awards win sent the internet into a frenzy We’re not getting emotional at all… Turn heads! These are the best beauty looks from awards season so far From showstopping to natural, they’re ones to consider for your dos.	cc/2020-05/en_middle_0111.json.gz/line2926
__label__wiki	0.936796	0.936796	NPD: March Video Game Sales Up, Final Fantasy XIII Leads By Matt Peckham Back in black, but only just, that's the story for March video game revenue according to figures released by retail sales tracker NPD Group. Combined hardware, software, and accessory sales hit $1.52 billion, up 6 percent over March 2009's total. Year-to-date we're still down 7 percent (a roughly $1.3 billion dollar deficit) compared to where we were end of March last year. Rebound or blip-recovery? It's too soon to say, considering all the months of depressing declines--holiday sales notwithstanding--that reach back to February 2009. NPD analyst Anita Frazier said prices were down 16 percent for console hardware, flat for software, but up in all remaining categories. That explains the precipitous 15 percent year-over-year decline in hardware sales revenue, and Frazier notes that unit sales, i.e. the actual number of consoles sold, were only down 5 percent. The other spot of bright news: March 2010 was the third best non-holiday month on record after March and June 2008, according to Frazier. Here's the March 2010 video game hardware sales breakdown, with growth compared to March 2009. 700.8k - Nintendo DS (+24%) 557.5k - Wii (-7%) 338.4k - Xbox 360 (+3%) 313.9k - PlayStation 3 (+44%) 119.9k - PSP (-29%) 118.3k - PlayStation 2 (+6%) Rah-rah Nintendo, it's like pulling a string on a doll each time the sales data comes in (even when they're down in year-over-year figures, they're "up" against anyone else). The DS led as usual and broke 700k for the first time in a non-holiday month since June 2009. Frazier said the Wii had its best non-holiday since March 2009, and the Wii was also the only console to bang out a month-over-month sales increase from February 2010. Continuing to play catch-up in year-over-year figures, the PS3 took top growth honors, up 44 percent over March 2009, though still lagging Microsoft's Xbox 360 and facing a roughly 10 million unit gap that's held more or less at parity for months. Check out the PSP though, with its 29 percent year-over-year drop. Sony's beleaguered handheld game machine dropped 33 percent last month and 42 percent in January 2010. That, taken in hand with the DS's colossal figures and March's overall sales uptick, looks pretty bad, any way you slice it. I mean, look at the PS2. Even it managed to squeak out a 6 percent increase. And the March 2010 video game software sales breakdown. 1.10M - God of War III (PS3) 1.02M - Pokemon Soulsilver (DS) 828.2k - Final Fantasy XIII (PS3) 825.5k - Battlefield: Bad Company 2 (Xbox 360) 761.2k - Pokemon Heartgold (DS) 493.9k - Final Fantasy XIII (Xbox 360) 457.4k - New Super Mario Bros Wii (Wii) 451.2k - Battlefield: Bad Company 2 (PS3) 429.6k - Wii Fit Plus w/Balance Board (Wii) 349.2k - MLB 10: The Show (PS3) No surprises here, though NPD's Frazier notes that God of War III topped God of War II's launch month sales by 32 percent. It's also the first month on record, if memory serves, in which the PS3 had more top 10 titles than the Xbox 360 (4 versus 2, respectively). That, and Final Fantasy XIII for the PS3 outsold the Xbox 360 version by 68 percent. Combined sales were 1.3 million, pushing FFXIII past God of War III for best franchise launch. Frazier noted that FFXIII sales were a whopping 48 percent higher than Final Fantasy XII's. Recall FFXII was PS2-exclusive. That should quash any remaining quibbles about the franchise's multiplatform mutation. And while Modern Warfare 2 didn't make the top 10, it's apparently just become the second-bestselling game of all time after Wii Play. Stay tuned for company spin analysis tomorrow morning. Follow us on Twitter (@game_on) Walmart coupons for January 2020 Walmart Tech Sale: 70% off Samsung TVs GoPro promo codes & coupons for January 2020 $50 bonus value on the GoPro HERO8 Black Bundle	cc/2020-05/en_middle_0111.json.gz/line2927
__label__wiki	0.874434	0.874434	Connected \\ November 22, 2017 By Rebecca Bednarz Opening in February, PlayTime is the first major thematic exhibition celebrating the role of play in contemporary art and culture. Music Credit: Green North by DKSTR [CC BY-NC-SA 3.0 US] PlayTime on pem.org — launched in September — allows us to reach beyond the museum’s walls and engage with a global community of users. It jumpstarts the conversation: how is play changing our lives? In advance of the exhibition, we’re exploring the shifting role of play in art and culture with leading writers, thinkers, game designers, poets, artists—and you. The exhibition features 40 works by 20 leading contemporary artists—including large-scale installations, sculpture, photographs, video, and tactile interactives—and examines how play catalyzes creative expression, enchants the ordinary and helps us understand ourselves in new ways. Play is important. While it seems unserious, it is at the root of creativity and human empowerment — Trevor Smith, Curator of the Present Tense and curator of this exhibition As chief of curatorial affairs and project lead, Kathy Fredrickson shares her excitement. “PlayTime has given us the opportunity to collaborate in new ways here at the museum and in doing so, to explore new ways of creating and sharing content. With this prototype, we can create opportunities for constructive dialogue and interaction, and offer broader, deeper and more diverse content than art museums usually provide to their audiences.” Nick Cave, still and detail from Bunny Boy, 2012, video (approximately 14 minutes). Courtesy of the artist and Jack Shainman Gallery, New York. Visit playtime.pem.org and the PlayTime Instagram for updates throughout the run of the exhibition. A few recent features to check out include: writer Virginia Heffernan on the seductive qualities of pinball in the digital age game designer Eric Zimmerman on cheating in games scholar and activist Susana Morris looks at the practice of playing with blackness writer Lizzie Stark on live action role play (LARP) sportswriter and memoirist Carlo Rotella on games growing up in his hometown of Chicago writer J. Robert Lennon with a playful piece of maze-like fiction artist Juliana Horner shares her unabashedly creative avatar-inspired makeup writer and game designer Kat Brewster on play as a product of boredom Albert Mobilio with a series of short stories inspired by vintage board games artist Claire Hentschker on her investigation of the video game Grand Theft Auto comic duo Adam Bessie and Jason Novak with a series of board game inspired web comics crossword writer David Steinberg with a custom game-inspired PlayTime puzzle In addition, we present the first video in our ongoing series Dispatches from the Field. Tune in and join PEM as we head out on the road to see the places and meet the players who make up the state of play today. Videos on playtime.pem.org will also include interviews with artists and thought leaders, as well as creative responses from artists and contributors to the PlayTime manifesto. The project has taken teamwork, for sure. A diverse group of curators, editors, interpreters, media producers and marketing specialists weigh in below on the idea of play and what they’re learning from this project: Gwen Smith, from the series The Yoda Project, 2002–2017, sixteen inkjet printed photographs. Courtesy of the artist. “It’s about taking risks and being vulnerable,” says Lydia Gordon, assistant curator for exhibitions and research. “It involves a letting go of preconceived notions or boundaries, and allowing oneself to be open to new possibilities, enjoyments, failures and risks.” Play is something so fundamental to humanity that we play every day—joking with friends, playing video games, or competing in sports—or even creatively using emojis! But it also builds and displays intelligence, develops knowledge of self and others and so much more. — Melissa Woods, communication specialist Chip Van Dyke, manager of media production, explains his role of bringing multimedia to the initiative, “Like with every project at PEM, I appreciate PlayTime because I get to both learn about and build the experiences that will help other people explore this topic.” Liz Gardner, interpretive planner, explains how her role is to think about the experience: From my experiences working with visitors, I’ve often observed that people still feel uneasy playing in museums. They have been trained that the only acceptable behaviors in a museum are to look, not touch, and be quiet. My hope is that PlayTime turns this notion on its head—and demonstrates that museums can be playful, lively, noisy, joyous spaces, too! Smith adds, “I appreciate that PEM is dedicated to providing people with opportunities to engage with the power of creativity and to understand how it might work in their own life. To understand that we begin to find our place in the world through play is something that is powerful and fundamental.” We invite readers to play along, too: what is play to you? Share your impressions with us on social media using #PEMplaytime. Check in early and often to play along with us—discover new writing on games and society, hear the artists talk about what play means to them, see our curators in action as we prepare for the exhibition, and learn how deeply and broadly play has permeated our culture. URL for this page Related \\ Stories You’ll Love Kirk was here Responding to Anila Agha	cc/2020-05/en_middle_0111.json.gz/line2930
__label__wiki	0.705313	0.705313	Sir John Tiptoft – 'Butcher of England' (Hardback) Earl of Worcester, Edward IV's enforcer and humanist scholar British History Medieval History Military England By Peter Spring Illustrations: 20 You'll be £25.00 closer to your next £10.00 credit when you purchase Sir John Tiptoft – 'Butcher of England'. What's this? Other formats available - Buy the Hardback and get the eBook for £1.99! Sir John Tiptoft – 'Butcher… ePub (13.8 MB) Add to Basket £10.00 Sir John Tiptoft – 'Butcher… Kindle (32.8 MB) Add to Basket £10.00 John Tiptoft, Earl of Worcester, is arguably the most intriguing, controversial and possibly misunderstood figure of the Wars of the Roses period. Politically adept, he occupied a string of important offices, first under the Lancastrian Henry VI and then the Yorkist Edward IV. A man of action, he held commands on both and sea, in England, Ireland and Wales. As Constable of England he acted as Edward’s enforcer and earned the sobriquet ‘Butcher of England’ for his beheadings and impalements. Yet he was also an outstanding Renaissance scholar who studied at Oxford, Padua and Ferrara, a collector of books and patron. This, in conjunction with his political actions, makes him a proto-Machiavellian Prince. Peter Spring also looks beyond the Earl’s public life to glean insights into the man himself, concluding that the available information generally reveals an attractive personality. He presents a balanced reappraisal, seeing him, as did many contemporary Europeans and some fellow countrymen, as a man of great intellect and capability who did not shirk the hard tasks imposed by a merciless age. Worcester’s execution for the application of Roman law, lampooned as the ‘laws of Padua’, demonstrated the danger of indentification with continental influences in an England increasingly defining itself—through common law, Parliament, and soon religion—against Europe. The contemporary denigration of his character by little Englander chroniclers reflected a deepening antipathy towards the cosmopolitan — a recurring trait in the English character — perhaps re-emerging with Brexit. This is a magnificent, heavyweight but readable and well-presented biography of one of the leading but most neglected characters in the War of the Roses. Spring takes us carefully through each stage of an action-packed life. Battlefields Trust Any biographer of Tiptoft is fortunate in that long narrative accounts survive of important episode in his life. They are used to great effect in this book and make interesting reading for scholar and non-specialist alike. Richard III Society Spring's telling of Tiptoft's tale is engaging, and its argument that the Butcher deserves reappraisal intriguing, if not wholly convincing. Times Literary Supplement, 22nd February 2019 – reviewed by Katherine Harvey You're really going to have to be a keen subscriber to the age to get through it. There is a nice mono, glossy plate section in the middle to show some of the locations being discussed and the appendices and bibliography will be useful for students. The Armourer, February 2019 About Peter Spring Peter Spring is a financial consultant by training but also holds an MA in Medieval Art History from the Courtauld Institute. He is has always been keenly interested in military history and has served in the Territorial Army in an Intelligence role. He lives in Southeast London. This is his first book. More titles by Peter Spring Saving £6.49 (50%)	cc/2020-05/en_middle_0111.json.gz/line2931
__label__wiki	0.507433	0.507433	These 7 Women Have The Jobs You Want— Apartment Marketing, Uncategorized Mar 6, 2017 0 Source: Glassdoor These 7 Women Have The Jobs You Want—Here’s How You Can Get Them! ~ Have you ever looked at a successful woman and thought, I want to be her or I’d kill for her job? While we can’t help you swap places or put you into your dream job, we did the next best thing: We went to seven of those successful women with super cool jobs to ask them how they think you can get to where they are right now. Here’s what they had to say. 1. Tiffany DeCruze, product manager for Priceline When you score a good deal on Priceline’s booking platform, you’ve got DeCruze to thank for it. She works with designers and developers to improve the site’s user experience, “so that customers can find great travel deals, book, and go,” she says. But although DeCruze is Priceline’s product manager now, she snagged this dream job without any real product marketing experience. Instead, she levied her experience and interests—including a love of travel—to snag the job. “I encourage women … to find a product they [love] and proactively seek to develop the skills needed to take on that role,” DeCruze says. 2. Cathy Polinsky, chief technology officer at Stitch Fix As Polinsky admits, “being part of a predominantly female company in the heart of Silicon Valley is such a rarity.” But that doesn’t mean there isn’t an opportunity for women to break into other, possibly male-dominated tech companies. No matter where you apply in Silicon Valley, she says, you just have to go for it. One way to do that is to share your career goals with your network. That way, when an opportunity comes up that matches your ambitions, you’ll already be on their radars. “They may start to think of you in a different light,” she encourages. 3. Melanie Casey, owner of Melanie Casey Jewelry Dream of turning a passion project into a full-fledged business? That’s just what Casey did when she launched her online store. “This is the only job in the world that I would willingly work seven days a week, and never get sick of it,” she says. The key to her success — and the tip she has for your business launch—goes beyond hard work, though. “The biggest change in my business came when I started taking product photography very seriously,” she shares. “I can’t say it enough: product photos are everything! If you take care with your imagery, people will discover your brand. From there, you can figure things out as you go.” 4. Yonna Ingolf, narrative designer of Candy Crush It’s not all fun and games in the gaming industry — but that doesn’t mean it isn’t a lot of fun. “I get to work with words, which is awesome because words are my favorite things,” says Ingolf. If you’d like to write for games, too, she says you should develop a real love of words. “Read a lot, write a lot, play a lot of games, and make some great connections within the industry,” she says. “It helps to have a degree, but you really don’t have to as long as you’re good at what you do, and determined to do it.” 5. Cristina Mariani-May, co-CEO of Banfi Vintners Of her job, Mariani-May says, “I work in the wine business — need I say more? Seriously, though, there’s a reason no one leaves this industry. It’s about the people, the relationships, the travel. I have the pleasure of working with a product that makes connections and brings happiness.” If you want to break into this industry — and climb to the top of a wine empire — Mariani-May says you should actually start at the bottom. “Get your foot in the door by working at a retailer,” she advises. “You need to get in front of the consumer, learn people skills, and understand people’s needs and how to help them. It’s a people industry, so get out there and network, attend tastings and other events, make friends, build relationships.” 6. Jenny Dorsey, culinary strategist Being a culinary strategist is an “active exercise in creativity,” Dorsey describes. She may consult with clients one minute, then run a dinner tasting pop-up the next. It took a big career change — and graduating from a culinary school — to get where she is, but Dorsey says it was her ability to embrace fear that others can copy to break into this unusual industry. “[When] you aren’t afraid to fail, that’s when your life is going to open up,” she says. “Ignore what your friends say or what your parents think. Dream big and try different things.” 7. Ilana Levine, host of the podcast “Little Known Facts with Ilana Levine” Whether you’re a born reporter or you simply have the gift of gab, launching a podcast could be for you. “I love connecting deeply with people and being inspired by others,” says Levine. Before you launch, Levine recommends you practice long before you have an audience. “There are books you can read about acting or podcasting, but nothing replaces the experience of actually doing it and realizing that at first, it won’t be perfect,” she says, referencing Malcolm Gladwell’s 10,000-hour rule, which asserts it takes luck and a lot of practice to get good at something. “No one can predict when or how the luck will happen, but you can start working on those 10,000 hours right now,” says Levine. New Austin Office Now… Penn Apartment Staffing is pleased to announce the opening of our new office located in Austin, TX at 7600 Chevy.. Penn Apartment Staffing Is… Penn Apartment Staffing Is A Credentialed Compliance Depot Vendor - Rick Penn Shares the Secrets to Success In Multifamily -.. Houston Office Now Doubled… Now This is Progress! - Even more ways to help our clients and team - Why not call or click.. Penn Employee Of the… Outstanding Work! 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__label__wiki	0.508722	0.508722	Back to Planned Parenthood of Tennessee and North Mississippi Planned Parenthood Planned Parenthood of Tennessee and North Mississippi Planned Parenthood of Tennessee and North Mississippi Current: Careers We're always looking for skilled and mission-driven people to join our team! Search All Available Jobs Planned Parenthood of Tennessee and North Mississippi is one of Tennessee's oldest and largest private, non-profit health care agencies. For over 75 years, PPTNM has remained committed to providing high-quality, affordable reproductive services and education throughout Tennessee, north Mississippi, and parts of Arkansas and Kentucky. Our mission is to improve health and well-being by providing high-quality, nonjudgmental sexual health care, honest and accurate sexuality education, and reproductive health and rights advocacy. Our dedicated and constantly growing team make this happen. If you'd like to be a part of a dynamic company providing necessary services to the community, please check out our available opportunities. FIRST-RATE EMPLOYEE BENEFITS We recognize that our employees work diligently, and we show our appreciation by offering them innovative perks and benefits. We realize and celebrate that our employees have diverse needs, and that this diversity requires flexible and customized programs that can be tailored to the specific needs of each employee. Choice of Medical and Dental Insurance Plans Vision Discount Plan Generous Paid Time Off (PTO) Policy Health Savings Account (HSA) Plans Short and Long Term Disability Insurance Retirement/401(k) Plan with Company Matching Life and AD&D Insurance Voluntary LIfe, AD&D Buy Up Options Workplace Values We Tend to the Team We Respect and Honor All People We Jump In We Try and We Learn We Care for Our Business We Return to Our Mission © 2020 Planned Parenthood of Tennessee and North Mississippi	cc/2020-05/en_middle_0111.json.gz/line2936
__label__wiki	0.86214	0.86214	Sixtysomething Elise Rainier might be old enough to retire. But that's the last thing on her mind. Instead, she's only concerned with using her psychic skills to help those experiencing nasty and nettlesome ghosty problems. In fact, she's thinking—with the help of her young techy sidekicks Specs and Tucker—that it's time to kick their ghostbusting biz up a notch. Now, don't think of that in the wrong way: This isn't some scare-the-chumps scam or anything like that. No, Elise is the real ghoul-grappling McCoy. Ever since she was a young girl, Elise has had a paranormal "gift," one that lets her see dead spirits and demonic entities. And to her considerable credit, she's demonstrated an unwavering inclination to help others with that unusual ability. But it's never been an easy burden to bear—for multiple reasons. Skeptics have scoffed at the very suggestion of someone being able to see spirits in another dimension, and they've rejected Elise and her ability out of hand. Why, Elise's own father, a prison warden, used to beat her, locking her in the basement anytime she mentioned seeing spirits around their house. And the fact that they lived on the state penitentiary grounds made for a regular parade of poltergeists (of recently executed criminals). When she wasn't dealing with her dad's abuses, though, Elise's childhood was still no stroll in the proverbial park. Her mother's demonically linked death, as well as other spiritual torments, arguably left her even more psychologically scarred than the bleeding lashes her father often left across her back. Yes, even now it's hard for Elise to think back on those painful formative years. But she's been forced to do so lately. That's because she and her ghostbusting team just got a call from a certain Mr. Garza, a man who needs their help with a spiritual infestation of sorts in his home—the very house Elise grew up in. Well, she did say she wanted to kick things up a notch. As someone in her 60s, Elise is quite physically frail and vulnerable. But she's also a determined, driven woman who's not afraid to face down the worst of otherworldly creepies—even to the point of putting her own life on the line as she does so. We eventually meet Elise's adult brother, Christian, and his two young-adult daughters. One of them talks of how much she loves her dad. "You don't know how happy that makes me," Elise responds. Elise subsequently works diligently to free one of those young women after she's spiritually attacked and has her soul stolen away. Elise is also willing to face very real-world dangers (from a man with a gun) when she and her crew discover a woman who's been kidnapped and held hostage. The main action of this flick involves encountering and struggling against evil spirits and ghostly entities. Sometimes those encounters take place in a bleak spiritual plane called The Further. These interactions never appear to have any connection to God or to a Christian conception of spiritual reality, however. Instead, they're just dark struggles with evil spirits. In fact, the one time that any of these creatures is beaten back by the power of "good," it's defined as the force of parental love. That said, we do see a large crucifix nailed to a wall in Elise's former home. And its current resident, Mr. Garza, has stacks of Bibles piled up, seemingly to ward off evil. He never speaks of any religious beliefs of his own, however. And Elise tosses a proffered Bible aside as being useless in her own battles against these entities. The film's primary source of evil is a demonic creature that a very young Elise almost accidentally releases into our world by unlocking a mystical "red door." This ghoulish thing has keys for fingers and keeps other spirits locked in metal collars, unleashing his torments upon them whenever he pleases. We also see real-world female captives locked in similar metal collars, and it's stated that the men who perpetrated those evils were possessed by this key-fingered demon. At one point, Elise is prompted to whip and torture someone in The Further. But she soon stops, realizing that her overflowing hatred and violence is only feeding the key-fingered spirit. A spiritual rescue operation of sorts involves a woman being hypnotized and sent into the The Further to rescue Elise's niece's captive soul and lead it back to her flesh-and-blood body in the real world. Elsewhere, ghosts frequently leap in and out of shadows. Some scream or pop into the frame with a shout. (Jump scenes abound here.) Young Elise recounts details of an executed prisoner's life after meeting his disembodied spirit. She also talks to a dead child about where spirits go after death. (To "the dark," she's told). Elise falls into a trance (both as her young self and as her older one) that transports her spirit to a dark realm. Spec and Tucker are a couple of geeky guys who make awkward, sometimes leering advances toward Elise's two nieces. Spec eventually becomes friendly enough with one of the young women, Imogene, to give her a kiss. Both of Elise's nieces wear somewhat low-cut tops. We also see a woman being held captive in a locked room who's wearing nothing but a dirty slip that covers her torso. Other female-looking spirits are dressed similarly. Recommended Resource A Chicken's Guide to Talking Turkey With Your Kids About Sex Even the bravest parents feel timid about discussing sex with their 8- to 14-year-olds! This resource offers reassuring, humorous, real-life anecdotes along with reliable information to help you with this challenging task. A gun-wielding assailant gets hit from behind with a club; when he falls to the ground, a heavy bookshelf is pushed over on him—crushing his head and leaving him in a pool of blood. This is the only truly bloody moment in this PG-13 film. But hardly the only violent one. We see many other painful looking, if bloodless, assaults throughout the balance of the film. Characters are thrown long distances, pummeled forcefully and impaled by sharp objects. A demon, for instance, has a broken cane jammed into its face. And we see a man beat a young woman to death with his cane. (The prone girl's body is just outside the view of the camera.) Elise's father lashes her across the back with his cane when she's just a young girl. We later see numerous scars and lash marks on her adult back. "I don't have memories of that place," she says. "I have scars." Someone with a wire wrapped around her throat is forcefully hoisted up and strangled to death by an unseen force. A woman is slammed forcefully into a basement wall as well. As she tries to escape, a demonic creature crawls to her, straddles her chest, drives a key into her throat to silence her cries, then cuts open her chest and drives another key into her heart. Later, something similar is done to another character. A young woman is found bruised, bleeding and locked up in chains in a dungeon-like room. The lights dim in Elise's childhood home when the nearby prison "fries someone" with an electrocuting charge. Elise's brother, Christian, accuses her, "You abandoned me to a real monster, our father." One f-word and one or two uses of "h---" join two exclamations of "oh my god!" Elise's father and Mr. Garza both appear to be heavy drinkers who swig glasses of booze or bottles of beer in an effort to dull the daily pain of life. Spec and Tucker's statements about women are eye-rollingly smarmy. This is a sequel to a prequel to 2011's original Insidious pic. But don't bother wringing your hands over any story bits you might have missed. It doesn't really matter if you've seen any of the previous three movies in this paranormal thriller franchise. They're all tied together with the most diaphanous and wispy story threads in any case. And when it comes to logic, well, that reasoning substance has never been more than a fleeting apparition in this series. So it is, for the most part, with The Last Key. The fact is, this flick could be considered the best of the Insidious horror lot. But that's only because actress Lin Shaye takes center stage here and makes us care for her vulnerable sexagenarian ghost hunter—a woman who wants to help those in need and passionately puts her own safety on the line to do so. Her earnest performance might have made for a rather watchable movie in the hands of a different filmmaking brain trust. Alas, instead we get pretty much what's come before: deep-black creepy jump scenes galore, torture-like child abuse and an inexplicable and grotesque demonic thingy—this time one with keys for fingers (?)—that does horrific things. Fill in the onscreen gaps with other screeching fetid ghosties and a bit of feeble ghostbuster-crew humor, and you end up with Insidious pic number four. It's a brainless and blanch-worthy way to start a new year of movies. But, hey, I guess we can only go up from here. Lin Shaye as Elise Rainier; Leigh Whannell as Specs; Angus Sampson as Tucker; Josh Stewart as Gerald Rainier; Kirk Acevedo as Ted Garza; Bruce Davison as Christian Rainier; Caitlin Gerard as Imogen Rainier; Spencer Locke as Rainier Adam Robitel ( ) Content Caution	cc/2020-05/en_middle_0111.json.gz/line2938

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