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__label__wiki	0.531476	0.531476	Vegan Mainstream Legal Restaurant-Food Service Marketing Research Nutrition Full time Non-Profit (18) Remote Job (7) Biotech (4) Media-Journalism (4) Veterinary Services (3) Environmental (3) Writer/ Editor (3) Engineering (2) Executive (2) Finance (2) Management (2) Strategy-Planning (2) Administrative Assistant (2) Business Development (1) Customer Service (1) Health Care (1) Other (1) Science (1) Science and Technology Associate Counterfactual Ventures London, UK Counterfactual Ventures (CFV) architects high-impact alternative protein startups to enable a maximally sustainable, humane, healthy, just and secure future of food. It is currently hiring for four exciting roles to become part of the core CFV team. As the Science and Technology Associate you will support the Research, Design and Build (RDB) team in high impact venture creation by working closely with the Head of Science and Technology. The RDB team includes both technical and commercial experts who work together to identify the most promising opportunities to build startups well-positioned to enable the alternative protein industry. Head of Science & Technology Counterfactual Ventures Counterfactual Ventures (CFV) architects high-impact alternative protein startups to enable a maximally sustainable, humane, healthy, just and secure future of food. It is currently hiring for four exciting roles to become part of the core CFV team. As the Head of Science & Technology at CFV you will lead all things technical in our venture creation studio and incubator. Alongside the Head of Venture Creation, you will lead a team in identifying the most promising opportunities to build startups well-positioned to enable the alternative protein industry. You will help the Talent Team identify optimal technical founders to carry 8 of these company concepts forward every 6 months into an incubation program and work closely with the Head of Incubation in supporting these young startups. Woodstock Farm Sanctuary High Falls, NY, USA Woodstock Farm Sanctuary envisions a peaceful world rooted in respect and justice for all living beings. We rescue farmed animals and give them care and sanctuary, connect animals with people to advance veganism, and advocate for animal rights in alliance with other social justice movements. At the heart of our mission is the hands-on work of rescuing, rehabilitating and caring for farmed animals, advocating for animal rights, and educating the public about these issues. We host thousands of visitors every year through our event, tour, and volunteer programs. Located in New York state’s Hudson Valley region 90 minutes from New York City, the area boasts a rich cultural and artistic heritage, offering a rare mix of rural and cosmopolitan resources. Job Overview: The Marketing Department is looking for its next savvy and creative Social Media Coordinator to join the team! The Social Media Coordinator will report to the Marketing and Communications Director while working... Research Specialist PETA Norfolk, VA, USA Animal rights advocacy organization seeks an excellent researcher with a strong academic background, solid detective skills, the ability to follow faint trails, and at least two years’ work experience and an advanced degree preferred. This position involves researching a wide variety of topics such as crocodile farming, cattle exports, and the training and housing of captive wildlife and domestic animals exploited in entertainment and for blood banks, applying critical thinking skills, preparing analyses for review, and submitting legal and government oversight agency complaints. Must support animal rights. Position Objective: To conduct research projects in order to help promote the goals of the organization Primary Responsibilities and Duties: • Thoroughly investigate complex areas of animal exploitation and abuse, as assigned • Ensure factual accuracy and sourcing for a variety of projects related to PETA's campaign work • Consult with the information... Digital Fundraising Analyst PETA Remote Position Objectives: To assist the PETA Foundation and supported organizations with online fundraising and lead-generation analysis. Primary Responsibilities and Duties: • In consultation with PETA Foundation and its supported organizations and verified compliance with the objectives, standards, and requirements communicated by them: o Compile and distribute ad results and analysis. Including reporting on donations, leads, and reach. o Analyze the results of ad tests, including creative, landing page, and copy tests. o Set up, monitor, and report on tests in Google Optimize. o Monitor digital ad audience populations and identify segments of supporters for retargeting. o In Tableau, create visual reports, ensure existing reports are functional and up-to-date, and monitor data syncs. o Analyze overall donation behavior, including, but not limited to, identifying areas of opportunity that we may be able to move the needle with digital ads. o Identify,... Position Objectives: PETA has the most-engaged social media audience of any advocacy organization. Sustain and grow PETA’s reach and online presence, be a visionary for PETA’s social efforts, and drive PETA’s messages, making sure they resonate with the public. Through innovative social media marketing, our Director of Digital Marketing will ensure our campaigns make a splash with influencers and the media, push forward PETA's edgy animal rights message, and are timely with current events and trends. Primary Responsibilities and Duties: • Supervise PETA's social media managers and live social media strategists • Oversee PETA's presence on social media platforms, including Facebook, Twitter, and Instagram • Oversee PETA's live coverage on Facebook, Twitter, Instagram, and Snapchat (including for protests, celebrity photoshoots, events breaking news, and more) • Oversee PETA's social media responding to the public and influencers • Work with other PETA... Faunalytics Remote Faunalytics is now accepting applications for our Research Scientist position! Faunalytics is a nonprofit organization that empowers animal advocates with access to the research and data they need to reduce animal suffering. We conduct essential research, maintain an online research library, and directly support animal advocates and organizations in their work to save lives. Our Research Scientists play an integral role in our small team by conducting original research studies (including study design, data analysis, and reporting/presenting results) and supporting animal advocates via our direct support services. We’re looking for candidates with research expertise and a deep commitment to animal protection. Responsibilities Primary responsibilities include: Designing rigorous scientific studies Managing data collection Analyzing quantitative and qualitative data Communicating results to a lay audience via written reports, infographics, oral... © 2009-2021 Powered by Vegan Mainstream	cc/2021-04/en_middle_0036.json.gz/line841
__label__cc	0.66054	0.33946	LOVE LEADERSHIP Alert: New book featured in Washington Business Journal “Booksmart” list of three recommended books by John Hope Bryant \| Oct 1, 2009 \| Love Leadership Book By Kevin Maney Hollywood studios have latched onto 3-D technology for roughly the same reason Bob Dole began taking Viagra. The main driver of the movie business — theatrical showings — has been going flaccid since the mid 2000s. So says Kevin Maney in “Trade Off.” Maney uses that colorful metaphor to begin to explain his theory, which he calls the “Fidelity Swap.” Virtually every business must balance the quality of its offering with their ease of use. The movie industry’s receipts have been declining because customers have found simpler ways to watch movies, either on DVDs sent through the mail or digital files, in their homes on ever-larger televisions. Hollywood, realizing that it can’t make movie watching much easier, has taken a shine to Vince Pace and his technologically advanced version of 3-D viewing. Pace and producer John Cameron are deploying the technology to make the movie “Avatar.” No word yet on how the former Kansas Republican senator is balancing quality with ease. Still, Maney offers several examples of ways executives have found the sweet spot within the fidelity equation. Broadway Books, $22, 214 pages The Silver Lining — An Innovation Playbook for Uncertain Times By Scott D. Anthony Too busy cutting costs and hoping for better times to see a silver lining in this economy? Too bad. You are missing a critical opportunity to expand your business. Scott Anthony, in “The Silver Lining,” says businesses cannot simply cut operations and try to move into new markets. Those steps might buy time or even eke out a bit more market share. But they will be no match for the market-changing forces affecting business today. Businesses must transform the way they operate, stop what they are doing and begin doing something starkly different. Take, for example, IBM in the late 1980s, when the company began facing intense competition from several angles. IBM responded in due course by changing much of what it does. Once a computer manufacturer, IBM now generates 60 percent of its revenue from providing services. “Silver Lining’ offers many examples and a step-by-step guide for assessing your business model and starting to change it for a new day. Harvard Business Press, $25, 210 pages Love Leadership —The New Way to Lead in a Fear-based World By John Hope Bryant Growing up in Compton in Los Angeles County, John Hope Bryant was engulfed in fear. The author of “Love Leadership” talks about criminals who threatened his entire hardworking community, the pull of gang life and the death of his best friend, George —in the first three pages. Bryant, at age 10, started a candy business and never looked back. Along the way he learned what he calls “bad capitalism,” or “ghettoized financial services.” All those enterprises succeeded by promoting fear. Bryant says it took him 30 years to learn that to be successful a person must offer love as a product instead of fear. He founded Operation Hope, the nation’s first nonprofit social investment banking organization. His guiding principles are: Loss creates leaders. Difficulty in life can create opportunity. Fear fails. Letting fear motivate your actions will lead to failure. Love makes money. Lead with love, and people will follow you forever. Vulnerability is power. Admit your weaknesses and own up to mistakes. Giving is getting. Doing good for others pays off. Jossey-Bass, $27.95, 203 pages — Timothy Burn	cc/2021-04/en_middle_0036.json.gz/line844
__label__cc	0.7125	0.2875	Pharmacogenetics of BCR/ABL Inhibitors Tag Archives: MK 3207 HCl Home / Posts Tagged "MK 3207 HCl" types (spp. infant formula Introduction Bacteria of the genus are progressively June 16, 2017 by Tracy Allen Posted in My Blog Tagged MK 3207 HCl, Rabbit polyclonal to PLOD3. types (spp. infant formula Introduction Bacteria of the genus are progressively important human being pathogens that cause neonatal meningitis and sepsis (Hunter and Bean, 2013). Enterobacterial infections have become a worldwide health problem partially due to the lack of development of preventive treatments and the emergence of fresh multi-drug resistant strains. has recently been reclassified like a (Strydom et al., 2012). varieties (spp.), previously known as spp. impact the central nervous system of babies, and survivors often suffer from severe neurological impairments such as hydrocephalus, quadriplegia, and developmental delays (Lai, 2001; Strydom et al., 2012; Jaradat et al., 2014). Varieties level classification of the genus, which includes spp. have been isolated from plant-based food products, including cereal, fruits, vegetables, legumes, natural herbs, and spices, as well mainly because from animal-based food materials such as milk, meat, and MK 3207 HCl fish (Friedemann, 2007; Lee et al., 2012). All spp., except spp. have been implicated in newborn MK 3207 HCl and infant infections, causing meningitis, necrotizing enterocolitis, and bacteremia (Healy et al., 2010). However, not all spp. are linked to infantile infections, and it is thought that virulence among strains may vary. are most often isolated from infantile instances (Joseph and Forsythe, 2011). Recent research based on international microbiological standards suggested that all varieties of must be absent in 10 grams of powdered infant method (PIF) (Odeyemi and Sani, 2016). For an understanding of recent unresolved issues persisting with respect to taxonomy, sources and medical relevance, and for suggestions on how to securely feed premature neonates (Holy and Forsythe, 2014), it is plausible that virulence determinants have evolved in certain lineages (Joseph et al., 2012a). Although reservoirs of spp. and their modes of transmission remain unfamiliar, spp. have been suggested like a source of food contamination, with rodents and flies offering as a secondary route of contamination (Jung and Park, 2006; World Health Corporation [WHO], 2007). Relating to a report by Jung and Park (2006), 20% of PIF samples were found contaminated with in the Republic of Korea. Lee et al. (2012) also reported similar results in which spp. were isolated from 18.6% of detected food samples. Although a number of reported cases of infection are quite low, sequelae can occur with high mortality rates (Lai, 2001; United States Food and Drug Administration [USFDA], 2002; Friedemann, 2007). World Health Organization [WHO] (2007), classified together with as group A pathogens associated with PIF with clear evidence of illness in infants. These categories of organisms were Rabbit polyclonal to PLOD3. based on their risk of illness to infants. Culture-dependent isolation and assay methods for complete analysis of spp. from PIF usually require 5 to 7 days (United States Food and Drug Administration [USFDA], 2002). A further method was recommended by the International Organization for MK 3207 HCl Standardization and the International Dairy Federation as ISO 22964 (Anonymous, 2006). This method includes a pre-enrichment in buffered peptone water (BPW), a selective enrichment in modified lauryl sulfate tryptose broth containing vancomycin and isolation of presumptive colonies colored in blue-green MK 3207 HCl on isolation agar. These colonies should be streaked on tryptic soy agar and resulting yellow colonies are indicatory for spp. from PIF using a real-time PCR-based assay and chromogenic agar. In their study, suspended cells were isolated from enrichment culture, streaked onto chromogenic agar, and confirmed by real-time PCR assay. Mullane et al. (2006) also developed a method using cationic-magnetic beads to capture spp., and subsequent identification was performed after washing off bound cells from the capture phase and plating them onto DrugganCForsytheCIversen formulation agar to detect 1 to 5 colony forming unit (CFU)/500 g of PIF within 24 h. However, these PCR-based methods have significant technical requirements of ultra-pure reagents and chemicals along with high equipment costs. Therefore, a rapid, sensitive, and inexpensive method is needed for the detection of spp. Polyclonal antibody can be obtained within a short time (4 to 8 weeks) with minimal financial investment, whereas it takes about 3 to 6 months to produce monoclonal antibodies (Leenaars and Hendriksen, 2005). Polyclonal antibody is commonly used in immunological methods, including enzyme-linked immunosorbent assay (ELISA), for the detection of foodborne pathogens (Brigmon et al., 1992; Kumar et al., 2008; Velusamy et al., 2010). It is also critical for developing a genus-specific and rapid method for recognition of spp. in. Supplementary MaterialsSupplementary material mmc1 Supplementary MaterialsS1 Table: Microarray data analysis showing differentially expressed genes in control versus t10,c12 CLA treated A2780 cells Supplementary Materials Supplemental Material supp_211_9_1857__index Supplementary MaterialsSupplementary Shape 1 Supplementary MaterialsAdditional document 1: Furniture S1-S4, S6: Story: Furniture detail 1) the TCGA download used in our analyses, 2) the markers analyzed in flow cytometry, 3) the candidate marker genes we derived from the literature, 4) the marker genes we ultimately determined, and 5) the genes present in the immunotherapy dataset of [31] Aldara reversible enzyme inhibition Anacetrapib ARRY-438162 Bafetinib BID BINA Cediranib CLDN5 Cyproterone acetate DMXAA Ecscr Emr1 IMMT antibody Iniparib IPI-493 Itga2b LRCH1 LY341495 Mocetinostat monocytes PA-824 PCI-32765 PDK1 PHA-665752 PIK-293 Quizartinib R547 Rabbit polyclonal to AMACR Rabbit Polyclonal to Amyloid beta A4 phospho-Thr743/668) Rabbit Polyclonal to BCAS3 Rabbit Polyclonal to BL-CAM phospho-Tyr807) Rabbit Polyclonal to FGFR1 Oncogene Partner Rabbit Polyclonal to Potassium Channel Kv3.2b Rabbit polyclonal to VPS26 SMOC1 SNS-032 SRT1720 HCl SU6668 Tonabersat Triciribine phosphate TRIM13 Vax2 WIN 48098 WYE-354 Y-33075	cc/2021-04/en_middle_0036.json.gz/line845
__label__cc	0.670502	0.329498	MUST - the independent Manchester United supporters' trust > FREQUENTLY ASKED QUESTIONS > Answers (FAQ) An open letter to the mods of the official Man Utd msg board As many of you know or have experienced, the moderators on the official Man Utd message board have expressed some concerns about Shareholders United. While we find it a bit strange that these individuals - given their positions - don't know the facts about us and have taken somewhat of a provocative stance against us, we wanted to address their concerns in an open and forthright manner consistent with the type of organisation Shareholders United is. The questions were articulated by a moderator who goes by the alias 'Condor'. The answers are interspersed with his questions. Originally Posted by Condor, one of the moderators on the club's message board There are many question about SU and its practises that dont get answered. If you are here promoting SU then perhaps you will give clear precise answers. Are there any audited accounts for SU for members to look at? Our accounts are professionally managed and are discussed in the full light of day at our AGM. See for example the minutes of our last AGM here: http://shareholdersunited.org/forum/...pic.php?t=1926 Further, our accounts are filed every year in accordance with the Companies Act and are available for the public to download from the Companies House website for a small fee (it's their fee, not ours so you know). http://wck2.companieshouse.gov.uk/31...search?link=41 There are no secrets with Shareholders United. We are an open organisation. You'd hardly get the same out of Malcolm Glazer. Try asking him for a full and complete accounting. Why does it cost £15 to join when you want potentially another 5,000,000 members? Actually, it's £10 UK, £12 EIRE/EUROPE, £15 ROW. The difference in prices accounts for the differences in postage. While the efforts of the elected directors and committee members are all done on a volunteer basis, things like advertising, mail shots, the newsletter, and printing are neither free nor cheap. There are also some modest costs associated with the administration of the Shareholders United Share Scheme and there is the odd social event as well. But basically your membership dollars help us defray our costs. Further, any charges or fees are made clear on membership forms and in our Constitution. We think it's important to note as well that if one wanted to buy a United share through a stockbroker you could do this (and that's fine with SU) but you have to pay a transaction fee of something like £15 to £25 before you could buy the share. Hence this SU membership is very attractive for many Reds. Why do members have to sign over their voting rights for someone else in SU to use? Why cant they retain their voting rights to use as they see fit? The truth of the process is that before each PLC AGM, Shareholders United hold a meeting for members to vote democratically (one person/one vote regardless of shares held) on how SU should vote the shares in the Share Scheme as well as the the shares any members with private shareholders have pledged to us via proxy. So it is the members of SU decide how the voting rights are exercised, not 'someone at SU' -- as if there were some secret cabal running this show. And these are people who go to Old Trafford every weekend, many of whom are members of IMUSA as well. SU is further supported by all of the major United fanzines - Red News, Redissue, and United We Stand. One of the benefits of exercising our shares collectively (through voting) is because as a bloc we have a far more substantial impact than we would by acting separately. There is one agenda at Shareholders United: to keep our club independent. If you are a member of SU, then this message is one that appeals to you. If you want to vote on your own, you are welcome to own shares privately and buy them through a broker. No one is stopping you from doing this, and actually Shareholders United are in favour of anything that gets more shares in the hands of supporters. But we think many find the Share Scheme both easier and cheaper vehicles for purchasing shares. How many share transactions do SU make in a year? What value of shares does that represent? We make one batch transaction per month, the value of which varies and increases on a monthly basis. Many of our members have private shareholdings which they've committed to the cause as well, and we continue to be in contact with shareholders asking them to pledge their shareholdings to vote with us. If you are interested in the ongoing figures, regular reports are provided at the open Committee (and Director) meetings and general meetings. Note: For the record, people with private shareholdings should know that their personal shareholding is not affected by joining SU. Whether you are a member of SU or not, the shares are always owned by YOU. What is the fee or precentage of transaction charged to SU for their annual share transactions? First, let's correct the misconception inherent in your statement. We give you a free share when you join and renew your membership. The fee for additional share purchases, either on a standing order basis or ad hoc basis, varies based on the number of shares purchased. But we have negotiated a very low rate (far lower than if you were do buy shares individually) with Brewin Dolphin Securities. How much is paid to representatives/committee members for their services annually? Glad you asked. None of the representatives or committee members makes a single penny off their work for Shareholders United. FULL STOP. We are all volunteers. Don't believe us? Come to the next AGM where you can hear how the money is truly spent. This is a horrible myth perpetuated by people who somehow believe our motives are suspect. They are not. We do this out of a love for our club and in defence of 126 years of tradition and support. In fact many of us spend just as much time (if not more) in support of this cause as we do our 'regular jobs'. And for some of us, this IS our 'regular job', one we gladly do for free How much is paid in other expenses for legal or investment advise? Most of the legal, accounting, and investment advice we are privileged to receive comes pro bono from reputable firms whose partners are sympathetic to our cause by virtue of their own support of Manchester United. We evaluate their performance annually and have always been quite pleased with their efforts. For the record though, we are registered at Companies House and the Share Scheme is backed/run in partnership with Cobbetts, Brewin Dolphin, and Co-Operative Bank and our legal advisors are Weil Gotshal LLP. Do any other parties, business, charities or individuals recieve any financial assistance from SU revenues? Another good question. While we have made an occasional donation to a worthy cause, the vast majority of your membership money goes towards SU activities, not those of any other organisation. If SU is ever dissolved all money goes to charity/local community. All this is articulated in our Constitution. We do provide free advice and moral support to a number of other supporters trusts. And we take up grievances of non-member supporters and branches for free with the Board. Now that we've got those questions sorted, let me add one thing for the record. Correct me if I have misunderstood you, but I take the tone of your questioning as being at least mildly provocative -- as if we were carpetbaggers hawking some sort of shady merchandise. You should know and understand the following: We are recognised by the Board as the official Supporters' Trust of Manchester United FC, we have regular dialogue with them, and we are represented at the Fans Forum. We have a link from official MU website. We are supported by the Government-backed Supporters Direct, the association of all football trusts in the UK. We have received support from FIFA and the Parliamentary All Party Football Group (chair Alan Keen MP) and Parliamentary Man Utd Group chair Tony Lloyd, MP for Manchester Central. The next time you want check out our credentials, you can also try checking with the Manchester United company secretary David Beswitherick, United finance Director Nick Humby, Chief exec David Gill or even United Chairman Sir Roy Gardner. We are 18000 strong, actively working to secure the independence of our club from the true carpetbaggers - the investors who would have us solely for profit and bankrupt the club. The people who lead us have been democratically elected in a one-person/one-vote process that ensures equality of voice regardless of one's means or shareholding. Again, if I'm wrong about the tone of your comments, I apologise. But Condor I seem to recall that we've had previous conversations about this matter. We're not the ones with anything to prove or disclose around here. Our hands are clean, our books are open, our intentions are honourable and our efforts are relentless. So in the future we'd appreciate it if you treated the members of our group with the respect they deserve. All they're trying to do is save their club. Whether you follow this path is your own choice, but do not look askance at theirs. In conclusion, thank you for your questions. Please do not hesitate to contact us in the future, or post your questions to our discussion forum. FAQ: http://www.shareholdersunited.org/faq.php FORUM: http://www.shareholdersunited.org/forum/ Shareholders United	cc/2021-04/en_middle_0036.json.gz/line847
__label__cc	0.695423	0.304577	Opioid prescribing practices following elective surgery in Otolaryngology-Head & Neck Surgery Mathew Biskup ORCID: orcid.org/0000-0002-9198-24031, Agnieszka Dzioba2, Leigh J. Sowerby2, Eric Monteiro3 & Julie Strychowsky2 Prescription opioid abuse has become a major issue across the world and especially in North America. Canada has the second highest number of opioid prescriptions per capita in the world, second only to the United States, with numbers continuing to rise in recent years. Surgeons play a critical role in this discussion as they are responsible for the management of post-operative pain in their patients. The objective of this study is to evaluate the opioid prescribing practices of Otolaryngologists-Head and Neck Surgeons in Canada and determine factors that may influence these practices. The online survey was distributed to members of the Canadian Society of Otolaryngology-Head and Neck Surgery. Questions surveyed the respondents’ demographics and opioid prescribing practices for common pediatric and adult elective surgeries. The survey was sent to 670 surgeons and trainees and 121 responses were received (18%). There was representation across all subspecialties with a mix of community and academic surgeons. The most commonly prescribed opioid was Codeine/Acetaminophen, 48.2% (n = 53), in the adult population, and Morphine, 47.1% (n = 41), in the pediatric population. The median total oral morphine equivalents prescribed across all adult surgeries was 123.75 mg (24.75 doses). The surgery with the highest oral morphine equivalents prescribed was tonsillectomy/adenoidectomy for both adult and pediatric patients, with a median of 150 mg (30 doses) for adults and 4.5 mg/kg (23 doses) for pediatrics. Gender, training years, year in residency, or reported level of conservatism did not predict the dose prescribed to either adult or pediatric patients. Due to the relatively low response rate, the generalizability of these results is unclear. Our study demonstrates a wide variability in opioid prescriptions across procedures and within each individual procedure. This variability reflects the lack of guidelines available for post-operative opioid prescribing and suggests that some Otolaryngologists may be prescribing higher doses of opioids than required. Opportunities for improving patient safety and resource stewardship regarding optimal prescribing practices should be explored. Prescription opioid abuse has become an epidemic across the world and especially in North America. Worldwide, Canada is second only to the United States in number of opioid prescriptions per capita, with numbers continuing to increase [1]. This can be attributed, at least in part, to a report released by the Joint Commission on Accreditation of Healthcare Organizations in 2001, which introduced pain as the “fifth vital sign” [2]. Many interpreted this as a recommendation to eliminate pain entirely, leading to a significant increase in opioid use [3]. As the risk of opioid addiction and diversion has become apparent over time, the total amount of opioid prescriptions in the United States has decreased annually since 2012, however, unlike the United States, Canadian prescriptions have continued to rise [4, 5]. In Canada, an estimated 13% of the general population used prescription opioids in 2015, with approximately 2.2% acknowledging opioid abuse. This resulted in an average of 13 opioid overdoses per day requiring hospitalizations and 2816 opioid-related deaths in 2016 [6, 7]. These numbers continue to increase, demonstrating the importance of health care practitioners only prescribing these medications when they are needed. Surgeons are responsible for approximately 10% of total opioid prescriptions, second only to chronic pain physicians in their proportion of opioid prescriptions [8]. Management of post-operative pain is an important part of peri-operative care, often treated with a short-term course of opioids to ease the recovery of the patient. To date, only general guidelines have been established for the management of post-operative pain control, with surgeons often arbitrarily prescribing the amount of pills required for individual procedures [9]. The surgeon must balance the need to adequately control the occasional experience of severe pain following surgery, while avoiding over-prescription, which is both a cost to the health care system and a danger to public health. This study used an explorative survey designed to investigate post-operative opioid prescribing practices among Otolaryngologists following elective surgeries in Canada. To collect the data, a 22-item questionnaire (Additional file 1) was developed and hosted on the web-based survey platform Qualtrics (version December, 2017. Copyright© 2017 Qualtrics). Development of the survey by the study team was based on critical review of the literature and clinical expertise. The survey was distributed to members of the Canadian Society of Otolaryngology-Head and Neck Surgery (CSO) via email. Eligible participants included members of the CSO actively practicing in Otolaryngology across Canada including residents, fellows, and staff. 670 individuals met the criteria and were distributed a link to the survey, along with the study letter of information and consent. A single reminder email was sent 3 weeks after the initial study invitation to encourage further response. The survey was designed to take approximately 5 min to complete. Survey items included respondents’ demographics, types of opioids prescribed, typical dosage and number of doses prescribed for common pediatric and adult elective surgeries in Otolaryngology-Head & Neck Surgery. The list of common surgical procedures performed across various subspecialties was formulated and agreed upon by our team. A French translated version of the survey was available to respondents. Survey responses were anonymous. Institutional ethics review board approval for this study was obtained from Western University in London, Ontario, Canada (REB# 111468). A descriptive analysis of study outcomes was performed. Frequency data for demographics, types of opioids prescribed, and items with Likert response scales were calculated. All opioid doses were converted to their oral morphine equivalent (OME) doses for further comparison. This conversion was done by multiplying the number of tablets prescribed by the strength of the tablets to get the total dose, then using an opioid conversion chart to find the potency ratio, which is multiplied by the total dose to find the total OME [10]. A separate conversion chart was used for the potency ratio of tramadol as it was not reported in the Canadian guideline [11]. For medications whose doses were reported in mg/kg, an average adult weight of 60 kg was used to calculate total dose in mg for comparison of data. The conversion numbers used along with an example calculation can be found in the Appendix. Pediatric dosing was reported as OME doses in mg/kg and found in a similar manner, which could be found in practice by multiplying the volume of opioid prescribed in mL, by the potency of the medication in mg/mL to obtain the total mg, then dividing the total OME found by the weight of the child to determine OME in mg/kg. Medians and ranges were calculated for opioid doses and number of doses prescribed. In addition to descriptive statistics, several statistical analyses were undertaken. Pearson chi-square tests were conducted to compare differences between residents and consultants and differences between males and females, in rates of opioids prescription for pediatric and adult elective surgeries, revealing no statistically significant differences (p > .05). As a result, groups were combined for all main analyses. Pearson chi-square analyses were conducted to evaluate differences between procedures in rates of opioid prescription. Furthermore, chi-square analyses were also undertaken to compare differences in rates of opioid prescriptions between adult and pediatric surgeries (tonsillectomy and/or adenoidectomy (T&A), tympanoplasty and/or ossiculoplasty and/or mastoidectomy (T/O/M), and, neck excisions). A comparison of differences in number of doses of opioids prescribed between adult and pediatric procedures could not be performed because doses were reported in terms of average OME prescribed for adult procedures and average OME/kg prescribed for pediatric procedures. However, separate analyses were undertaken to evaluate differences in dosages prescribed between procedures; due to the nonparametric distribution of the data, Wilcoxon signed-rank tests were performed. Finally, linear regression analyses were conducted to determine if gender, training years, year in residency, or level of conservatism were related to number of doses prescribed for adult procedures (i.e., OME) and pediatric procedures (i.e., OME/kg). Data were analyzed using the statistical package for the social sciences (IBM Corp. Released 2017. IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp). Statistical significance was determined a priori at the alpha level of .05. Of the 670 eligible individuals who were emailed the survey, we received 121 responses for a total capture rate of 18%. This included responses from 98 out of 500 (19.6%) consultants and 23 out of 170 (13.5%) residents. Of the 121 responses received, 4 (3.3%) were completed in French. There was a distribution across all Otolaryngology subspecialties and a mix of community and academic surgeons. Full demographic data is reported in Table 1. Table 1 Respondent demographics There was a wide distribution in the percentage of patients prescribed opioids by the respondents as displayed in Fig. 1. 84.5% (n = 98) of respondents endorsed prescribing a variety of opioids, while the remaining 15.5% (n = 18) routinely prescribe only one type of opioid. 76.8% (n = 73) respondents reported mechanisms in place at their medical center to track whether prescriptions had been filled. When asked if respondents believed that opioids are overused, 8.2% (n = 8) strongly disagreed, 23.7% (n = 23) somewhat disagreed, 20.6% (n = 20) neither agreed nor disagreed, 34.0% (n = 33) somewhat agreed and 13.4% (n = 13) strongly agreed. Regarding respondents’ self-reported degree of conservatism in opioid prescribing, with 1 being ‘not at all conservative’ and 10 being ‘extremely conservative’, responses ranged from 2 to 10 with a mean (SD) of 5.98 (2.18). Specific opioids were used by respondents in various frequencies, with the most widely used opioid being Codeine/Acetaminophen with 64.5% (n = 78) of respondents, followed by Morphine with 56.2% (n = 68). For respondents who serve the adult population (n = 110), the most commonly prescribed opioid was Codeine/Acetaminophen at 48.2% (n = 53), while Morphine was the most common opioid prescribed by respondents who serve the pediatric population at 47.1% (n = 41/87). The full distribution of opioids used can be seen in Fig. 2. Proportion of respondents who prescribed opioids to each percentage range of patients post-operatively Distribution of specific opioid prescriptions by respondents Results of opioid prescribing were analyzed based on adult versus pediatric populations. Of respondents who served both pediatric and adult populations, respondents were statistically significantly more likely to prescribe opioids to adult than pediatric patients for T&A procedures (χ2 = 5.74, p = .02), and T/O/M procedures (χ2 = 4.87, p = .03) but not for neck excision procedures (χ2 = 2.96, p = .09). Of the surgeries performed in an adult population, the median total OME prescribed was 124 mg corresponding to 25 × 5 mg tablets of Morphine. Data for the proportion of respondents that did not prescribe opioids for each adult procedure is reported in Table 2; statistically significantly difference between all pairs of adult procedures were found. (χ2 = 7.53 to 73.67; p = <.01 to <.001). Table 2 Adult surgery opioid use The surgery with the highest total OME was a tonsillectomy and/or adenoidectomy, with a median of 150 mg (30 tablets or doses) OME and an interquartile range from 120 mg (24 tablets) to 206.25 mg (41 tablets), while the lowest prescriptions were seen in functional endoscopic sinus surgeries with a median of 112.5 mg (23 tablets) OME and an interquartile range from 75 mg (15 tablets) to 135 mg (27 tablets). Differences in median OME opioid prescribed for adult tonsillectomy and/or adenoidectomy were statistically significantly higher than all other adult elective surgeries surveyed (Z = − 3.81 to − 4.64, p < .001). In addition, median OME opioid prescribed for septorhinoplasty procedures were statistically significantly higher than FESS procedures (Z = − 2.52, p = .01). All other pairwise comparisons of OME opioid prescriptions between adult procedures were statistically nonsignificant (p > .05). The distribution of responses for each adult surgery can be seen in Table 3 and Fig. 3. Table 3 Adult surgery opioid prescribing Discharge opioid prescribing across various adult Otolaryngology elective procedures For pediatric surgeries, 83% (n = 73) of respondents reported using medications with per kilogram dosing, including Morphine and Hydromorphone, while the remainder used medications with set tablet doses including Codeine, Codeine/Acetaminophen, Tramadol/Acetaminophen and Oxycodone/Paracetamol. For each individual surgery, a set of respondents reported not prescribing opioids as seen in Table 4; differences in rates of no opioid use were statistically significant between all pairs of pediatric procedures (χ2 = 28.90 to 46.70; p < .001). Table 4 Pediatric surgery opioid use All data below is reported for medications using per kilogram dosing due to the low number of responses for tablet-dosing. Across all surgeries, the median OME was 4 mg/kg with an interquartile range of 2.38 to 6.38 mg/kg. The highest median OME/kg was reported for T&A at 4.5 mg/kg with an interquartile range of 2.31 to 7.97 mg/kg. T/O/M and, excision of a neck mass shared a median of OME/kg at 4 mg/kg and a range of 2.00 to 7.25 mg/kg and, 3.38 to 8.25 mg/kg respectively. Differences in median OME/kg opioid prescriptions between T&A and both T/O/M and excision of a neck mass were statistically significant (Z = − 2.03 to − 2.61, p = .01 to .04). The results across all surgeries as well as those for tablet-based prescriptions can be found in Tables 5 and 6 and Fig. 4. Table 5 Pediatric surgery opioid prescribing (weight-based medications) Table 6 Pediatric surgery opioid prescribing (non weight based medications) Discharge opioid prescribing across various pediatric Otolaryngology elective procedures Regression analyses were undertaken to look for factors that may influence the amount of opioids prescribed for adult and pediatric procedures. Simple linear regression models indicated that gender, training years, year in residency, and reported level of conservatism did not predict the OME dose prescribed to either adult or pediatric patients (p > .05 for all regression models). Surgeons may often be tempted to prescribe higher quantities of opioids than required to avoid the possibility of patients returning due to inadequate pain management. This practice can place patients in danger of developing a dependence to these medications which can result in chronic use [12, 13]. A recent review article reported that anywhere from 67 to 92% of surgical patients reported unused opioids following surgery, with very low rates of safe storage or disposal [14]. Similarly, a study published in 2017 by Thiels et al., looked at opioid prescriptions among 7651 patients undergoing a variety of elective surgeries and found that over 80% of patients were overprescribed opioids [15]. These excess pills can occasionally be diverted into the illicit market or taken by adolescents and young adults in the home for recreational use [16, 17]. Previous studies have been carried out to document prescribing practices of surgeons post-operatively in the fields of Orthopedics, General Surgery, Obstetrics, Oral Maxillofacial Surgery and Dermatology [18,19,20,21,22]. Most recently this has also become a hot topic in the field of Otolaryngology - Head and Neck Surgery with multiple papers published on the topic within the last year [23,24,25,26,27]. These studies looked at opioid prescribing practices in the United States, however there have been no studies published examining opioid use in Canada. The present paper aims to fill this gap in literature, to evaluate the prescribing habits of Otolaryngologists in Canada, and determine factors that may influence prescribing practices. Due to the relatively low response, the generalizability of these results is unclear; however, our results suggest that there is significant variability in opioid prescribing practices across all elective procedures for both adult and pediatric patients in Otolaryngology - Head and Neck Surgery in Canada. There is an ongoing epidemic of opioid use with associated dangers such as addiction and overdose, yet there is a lack of established procedure-specific and age-specific standards or guidelines for physicians to follow. This is evidenced by the similar opioid prescribing amounts across a range of dissimilar procedures with expectantly differing amounts of pain, as seen in our results. Physicians and surgeons often estimate appropriate and safe dosing for their patients and may not receive feedback from their patients regarding how many pills were actually consumed and whether their pain management was adequate. This variability is not unique to Otolaryngology - Head and Neck Surgery. Recent studies in the areas of upper extremity surgery, Maxillofacial surgery, hand surgery, Urology and General surgery consistently show wide variability across different procedures and within each individual procedure [19, 28,29,30,31]. Often out of convenience to both the patient and the physician, the amount of opioids prescribed may be overestimated to ensure that the patient will not need to refill their prescription or present to the emergency department for uncontrolled pain. This thinking may be flawed however, as the inherent risks of overprescribing seem to outweigh the benefits of overprescribing. Studies have suggested that up to 70% of opioid pills prescribed post-operatively go unused [19, 28]. Hill and colleagues (2017) estimated that the amount of opioids prescribed could be decreased by 43% if they allowed for the possibility of up to 20% of their general surgery patients to require refill. Operationalizing this idea, another study by Hill et al. (2018) used an educational intervention for physicians, encouraging the use of non-steroidal anti-inflammatories and acetaminophen, and decreased opioid prescription amounts. This resulted in a 50% decrease in prescriptions with only a 0.4% refill rate during their study [32]. Within Otolaryngology - Head and Neck Surgery, a recent US national database study examining ambulatory opioid prescribing found that approximately 1 in 133 patients are seen in ambulatory clinic regarding post operative pain management that requires an opioid prescription [23]. A similar survey study design by Schwartz et al. (2018) was recently published that examined opioid prescribing of Otolaryngologists in the United States [24]. The procedure with the highest opioid prescriptions was similarly tonsillectomy, with a mean of 37 tablets (similar to the reported mean of 33 tablets in this paper). The remainder of the procedures had similar results to ours, however the American study had more variability between procedures including tympanoplasty, mastoidectomy and soft tissue excision, which had lower rates of prescription opioids compared to our study. In regards to specific opioids used, the American study found that the most commonly prescribed opioids were Hydrocodone followed by Oxycodone, in contrast with Codeine/Acetaminophen and Morphine being the most commonly prescribed in our study. The American result is consistent with other studies examining post operative opioid prescribing in the United States [19, 25]. In Canada however, Hydrocodone is only approved for treatment of cough as opposed to pain control and Health Canada has warned against its use in children and adolescents [33, 34]. This, along with different national prescribing trends, likely explains the discrepancy in our results. Concerningly, this study found that codeine was still being used in children despite FDA and Health Canada warnings about its use in children. Codeine is metabolized in the cytochrome P450 pathway in the liver and it has been found that codeine can be metabolized differently by different individuals, with some being ultra-rapid metabolizers and others being poor metabolizers [35]. This creates an inconsistent medication effect profile and can be dangerous in children leading to possible overdoses in those known as ultra-rapid metabolizers [36]. A recent study by Chua et al. (2017) looked specifically at the use of Codeine in pediatric T&A and found that although there had been a drop in codeine prescriptions following an FDA warning in 2012, approximately 5.1% of children received codeine for pain control following T&A in 2015 [26]. Health Canada recommends against the use of Codeine in children under 12 [34]. The FDA previously had a similar recommendation against the use of codeine in patients under age 12, however the recommendation was amended to include patients up to age 18 as part of a safety announcement released in January 2018 [37]. In our study, we found that 8% (n = 7) of the respondents continue to prescribe codeine to pediatric patients (Codeine 1.1% (n = 1) and Codeine/Acetaminophen (n = 6)). Of these responses, all but one for Codeine/Acetaminophen indicated its use only in the adolescent population. Unfortunately, the threshold for the older versus younger children was not specified in the survey, so it is unclear whether the remaining 6 respondents were prescribing to children below the age of 12. Another concern, discussed in the CDC paper by Shah et al. (2017) was the use of tramadol and it's risk of long term dependency [38]. The study found that there was a 13.7% risk of chronic use at 1 year with tramadol compared to short-acting opioids other than hydrocodone and oxycodone at 8.9% and hydrocodone and oxycodone the lowest at around 5%. This result may be surprising as tramadol was thought to be relatively safer due to its lower affinity for μ-receptors [39]. This thinking may explain the relatively high use of tramadol we saw in our study, either alone or in combination with acetaminophen. However, this prescribing practice may bring about an unintended risk onto our patients. Despite the CDC warning against the use of tramadol in children under 12 as well as the FDA and Health Canada warnings suggesting tramadol should not be used in patients under 18, there remained respondents that used this medication in the pediatric population [36, 40, 41]. Lastly, it is important to note that opioids, at the appropriate doses, are both safe and effective after pediatric surgeries such as T&A’s and remain an important part of post-operative care [42]. To date, there has been very little research or guidance on the requirement for opioids in elective Otolaryngologic procedures. One study by Patel et al. (2018) looked specifically at opioid prescribing post-rhinoplasty and found that of the typical 20 to 30 hydrocodone tablets initially prescribed, a mean of only 8.7 were consumed, with approximately 75% of the patients consuming less than 15 [27]. Although just one procedure, this demonstrates the discrepancy in the amount of opioids prescribed compared to what is actually used by the patients. In a clinical practice guideline from Minnesota discussing opioid use for acute pain, they recommended that no prescriptions should exceed 200 OME or 7 days [43]. This corresponds with a CDC guideline in 2016 recommending no more than 7 days with sharply increased risks of long-term use after 5 days [44]. Similarly, a quality standard by Health Quality Ontario suggests that 3 days of opioids is often sufficient and greater than 7 days is rarely indicated [45]. In our study, the interquartile range for all procedures fell below this limit with the exception of T&A, which crossed just above this recommended limit. This information corresponds to another study by Thiels et al. (2017), which looked at the variations in opioid prescribing in various procedures across multiple specialties and found that the only procedures that fell below the 200 OME limit were those involving the neck [15]. Whether this speaks to opioid prescribing practices of Otolaryngologists, minimal pain following Otolaryngology procedures or a mix of both is unclear, however this demonstrates that current prescribing practices may not be far off what is recommended. Our results are limited by our response rate (18%) and our study design, which asked respondents to estimate their usual prescriptions for each procedure. This does not take into account individual patient factors, which may influence prescribing practices. We did not obtain information on other pain management strategies used including non-opioid analgesics and were not able to determine the percentage of opioids used by patients. It should also be noted that resident prescribing practices may be highly influenced by practices of the consultants under which they work rather than individual preference. This could explain why resident prescribing closely matched that of consultants and may have resulted in the practices of consultants who work in academic centers with residents to be over represented compared to what is reported. This study shows a wide variability in both the types of opioids prescribed as well as the amount of opioids prescribed for adult and paediatric elective procedures in Otolaryngology - Head and Neck Surgery. The majority of opioids prescribed seem to be within recommended maximums, but these maximums are generic and not procedure-specific. Some Otolaryngologists are continuing to prescribe certain opioids despite emerging evidence of harm regarding medications, such as codeine and oxycodone in the pediatric population and possibly tramadol in the adult population. Further research and quality improvement interventions should be focussed on guiding Otolaryngologists on appropriate prescribing practices with goals of improving patient safety, reducing opioid over-prescription, and guiding appropriate resource stewardship. The datasets used and/or analyzed in this study are available from the corresponding author on reasonable request. CSO: Canadian Society of Otolaryngology-Head and Neck Surgery OME: Oral Morphine Equivalent T&A: Tonsillectomy and/or Adenoidectomy T/O/M: Tympanosplasty and/or Ossiculoplasty and/or Mastoidectomy International Narcotics Control Board. Narcotic drugs: estimated world requirements for 2016, statistics for 2014. United Nations; 2015. Joint Commission on Accreditation of Healthcare Organizations Pain Standards for 2001. Joint Commission on Accreditation of Helathcare Organizations; 2001. Lucas CE, Vlahos AL, Ledgerwood AM. Kindness kills: the negative impact of pain as the fifth vital sign. J Am Coll Surg. 2007;205:101–7. Centers for Disease Control and Prevention. Annual Surveillance Report of Drug-Related Risks and Outcomes — United States, 2017. Centers for Disease Control and Prevention, US. Department of Health and Human Services; 2017. https://www.cdc.gov/drugoverdose/pdf/pubs/2017-cdc-drug-surveillance-report.pdf. Accessed 28 Dec 2017. Canadian Institute for Health Information. 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Characteristics of initial prescription episodes and likelihood of Long-term opioid use — United States, 2006–2015. MMWR Morb Mortal Wkly Rep. 2017;66:265–9. Babalonis S, Lofwall MR, Nuzzo PA, Siegel AJ, Walsh SL. Abuse liability and reinforcing efficacy of oral tramadol in humans. Drug Alcohol Depend. 2013;129:116–24. Center for Drug Evaluation and Research. Drug Safety and Availability - FDA Drug Safety Communication: FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women. https://www.fda.gov/Drugs/DrugSafety/ucm549679.htm. Accessed 15 Apr 2018. Health Canada. Summary safety review - tramadol-containing products - assessing the potential risk of serious breathing problems (respiratory depression) in children and adolescents. aem. 2017. https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/safety-reviews/summary-safety-review-tramadol-potential-risk-serious-breathing-problems-children-adolescents.html. Accessed 15 Apr 2018. Hamunen K, Kontinen V. Systematic review on analgesics given for pain following tonsillectomy in children. Pain. 2005;117:40–50. Opioid Prescribing Work Group. Opioid Presribing improvement program. 2017. https://www.leg.state.mn.us/docs/2017/mandated/170919.pdf. Accessed 9 Apr 2018. CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016. MMWR Recomm Rep 2016;65. doi:https://doi.org/10.15585/mmwr.rr6501e1er. Health Quality Ontario. Opioid prescribing for acute pain: Care for People 15 years of age and older. Toronto: government of Ontario; 2018. http://www.hqontario.ca/portals/0/documents/evidence/quality-standards/qs-opioid-acute-pain-clinician-guide-en.pdf. Accessed 28 Dec 2017. We would like to thank Josee Paradis, MD, FRCSC, for translating the survey into French and Alexandra Biskup, NP, MSc, for assistance in editing of the manuscript. Division of Otolaryngology-Head & Neck Surgery, Dalhousie University, QEII Health Sciences Centre, 3rd floor Dickson Building, 5820 University Avenue, Halifax, NS, B3H 1Y9, Canada Mathew Biskup Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada Agnieszka Dzioba, Leigh J. Sowerby & Julie Strychowsky Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada Agnieszka Dzioba Leigh J. Sowerby Julie Strychowsky MB performed a literature review, helped with ethic approval, assisted in design of the survey, helped with the interpretation of results and wrote the manuscript. AD applied for ethics approval, created the survey, performed statistical analysis and helped with the writing of the manuscript. JS generated the idea for the research, helped with literature review, the creation of the survey and interpretation of the data as well as provided guidance throughout the entire research process. LS helped with the formulation of the research project and the creation of the survey, as well as provided guidance throughout the research process. EM provided guidance for the project including preparation for joint admission. All authors read, edited and approved the final manuscript. Correspondence to Mathew Biskup. Institutional ethics review board approval for this study was obtained from the Research Ethics Board at Western University, London, Ontario, Canada, reference number 111468. All participants received a letter of participation and consent prior to completing the survey, agreeing to have their information pooled and published in an anonymized fashion. Opioid prescribing survey (DOCX 18 kb) Table 7 Opioid conversions Conversion Example If a prescription was Hydromorphone 1 mg PO q4h prn, Dispense: 30 (thirty) × 1 mg tablets, it could be converted to total OME as follows: Total Dose = # of tablets x strength of tablets = 30 × 1 = 30 mg Hydromorphone. In the conversion table, the potency ratio for hydromorphone is 5, thus Total OME = Total Dose x potency ratio = 30 × 5 = 150 mg OME. Biskup, M., Dzioba, A., Sowerby, L.J. et al. Opioid prescribing practices following elective surgery in Otolaryngology-Head & Neck Surgery. J of Otolaryngol - Head & Neck Surg 48, 29 (2019). https://doi.org/10.1186/s40463-019-0352-9 Post-operative pain Prescribing patterns	cc/2021-04/en_middle_0036.json.gz/line848
__label__cc	0.522492	0.477508	Home > LIVE and WORK > MANNERS Things in Japan that Tourists Hate Japan is a dream destination attracting people of all ages and walks of life. The attraction is mutual, as Japan’s government is setting a goal of welcoming 40 million tourists in 2020 and 60 million by 2030. However, as in all popular tourist destinations, miscommunications arise, creating discomfort in both locals and visitors. The problems… Japan Has a Mascot For Everything – Even Piracy Everybody knows how large Japan’s entertainment industry is. From blockbuster video games to manga one-shots, you can find a wide range of genres and interests to enjoy in Japanese entertainment. Unfortunately, many of these products are prime targets for theft and piracy. Manga piracy is the most prominent, with entire chapters from popular magazines like… How to Avoid Culture Shock While Living in Japan Culture shock is an inevitable topic amongst expats in Japan. Inevitable social misinputs and missed social cues can wear anyone down. After the novelty of being surrounded by the Japanese language wears off, some people find themselves socially isolated and functionally limited because of their lack of Japanese ability. Having to go through an awkward… Survive Japan’s Trains With This Guide While Japan’s rail system is famed around the world for its scope and efficiency, it can be an intimidating thing to go through for someone new to Japan. Busy maps, crowded stations, and the ever-present Japanese language barrier can make it challenging for newcomers to efficiently travel on Japan’s many trains and subways. On top… Interning In Japan – Tips and Tricks It is human nature for every single person to have the innate feeling of wanting to explore. Personally, there was always something in me yearning for more. Beginning college, I was shaken by a feeling of complacency and it was a feeling that made me angst. I am young and in college, what was I… 5 myths about Japanese subways that aren’t always true With more than 8 million tourists visiting Japan each year, many stereotypes have been created to explain Japanese culture to friends and family back home. However, there are almost always exceptions to these stereotypes, none more evident than those pertaining Japanese public transportation etiquette. Learn these 5 myths before your first trip to Japan so… Always Remember These 10 Big No-Nos When You Are in Japan! Every country has its own taboos, rules, and cultural restrictions. These can differ enormously from nation to nation or between continents. Western societal norms may seem normal to a western person, but seem completely alien to someone from a different part of the world. These stark differences can create something of a culture shock for… Basic table manners in Japan There is, for sure, a set of rules and manners in eating regardless what country a person comes from. Some of these table etiquette rules may be the same in most countries, and some may surprise you because they are the exact opposite. jp.fotolia.com/ It is always advantageous to learn some table manners for a… Some Manners To Understand Before Using a Public Toilet in Japan Japan is well-known for having the tidiest public toilets in the world. Somebody might even consider Japanese toilets the best of those they got to use. It is because the manner of keeping the public toilets clean is in Japanese mentality, and this results in the clean toilets available to everyone. Moreover, public toilets in… What is the reason Japanese are Annoyed and Irritated with Foreigner Tourists ?! As the Tokyo 2020 Games steadily approaches, Japan expects a great number of foreigners to come starting from this year. However, together with foreigners also comes the Japanese citizens’ dissatisfaction created by the big number of tourists that is increasing by year. In a Japanese TV Show called ZawaTsuku(ザワつく), the Japanese brought into attention some… Page 2 of 5Prev12345Next What to Do During the Japanese winter? Sep 7, 2015 5 Picturesque Canals to Check Out and Enjoy Nature in Japan Dec 21, 2015 Can You Win the Heart of a ‘Tsundere Girl’ in This New Dating Game App? Sep 17, 2016 35 Things to Do in Ryogoku, the Traditional Town of Sumo, in 2019 Jan 1, 2019 Discover Tottori: Mitokusan Mar 31, 2015	cc/2021-04/en_middle_0036.json.gz/line849
__label__cc	0.627427	0.372573	On stranger tides: Andreas Wolff "Oh no, he can't be faster than me!" Tomasz Fąfara Grzegorz Trzpil “That’s actually a great idea!” I admit honestly when he shares his suggestion on how to create more interest among the Champions League in the future. “Thank you,” he answers humble and asks immediately “Is this recorded?!”. Ah yeah, compliments are always very welcome by Andreas Wolff. You know this theory of boxes in man’s head with a huge “nothing box” in the middle? I’m pretty sure that instead of this Andi has got a big box with all compliments he has ever received from people and he keeps it in special cuddly area of his mind. And yes, I’m also sure he opens the box quite often. Ahead of the beginning of the season 2020/21, the captain of Polish Champions shares a little bit of his thoughts. In first part of the long pre-season interview Andreas Wolff talks about preparations with refreshed team, difficult time of pandemics and changes in formulas of both domestic PGNiG Superliga and European Champions League contests. After long time of social distancing suddenly you are back to business with 25 people around. Wasn’t it a shock for you to exchange silent empty house for such a crowded place? I can promise you that my house was never silent! – Andi answers with a tone of an old mate instructing a younger buddy in a way “Dude, what do you know about life?” – I was at TeamSpeak with my friends all the time as I started streaming, so I had some social contact. Of course, not the one we are used to like meeting each other everyday and doing sports, but at least we had some e-sport (more about it in second part of the interview coming soon - ed.). But I am really happy that the season is about to start again and we are back to handball business! I missed these everyday visits in the hall. Handball is my job, but first of all it’s my passion, my most loved hobby. And we all couldn’t have done it for months, so I am so excited we started again. Maybe apart from the running part – he grimaces and after a short break adds some Oscar Wilde’s like maxim – But you know, there is no light without shadow. Yeah, talking with Andi is always like drifting on stranger tides. Once he profoundly answers your question, moment later adds some racy joke and then comes with a philosophic thought that you would never suspect him to have. Fun for advanced users. And these who can still stick to their course when the wind change direction. How did the team survive the quarantine time especially when there appeared the information about financial problems? It’s difficult when you lose some money at work, but all the players still wanted to play for the club. Actually, what could we do? Stop playing? As I said, handball is not just our job, it’s much more. Of course the guys were worried a little bit about the future, you still need to secure your family and that’s important. But we really don’t play just for money. We work for ourselves, for our teammates, for the club. Money is an issue, but not the most important thing in the world. You know, it’s not only about the fact if I get all my money or not. For me it’s far more important how the situation is handled by the club. I really like the way Bert is fighting for the club. When the problems appeared he could have just quit. Instead of this, he is fighting. And as long as he is, I will as well. But finances are not my job. I get paid for playing handball and this is what I focus on. Following this path the captain took care more about the team spirit and what can keep athletes together better than sport? Andi almost forgot it, but when the restrictions got loosen a bit and it was possible to train in smaller groups again he inspired players that were still in Kielce to meet in the arena. Ah, right – he laughs – I was in the gym with Doruk once and we met Talant. I asked him if it’s possible to train a little bit and he agreed, so I asked guys “who wants to play?” and this is how we organised a group of 6-7 players that started to train a bit. It was really nice! Jak selfie, to tylko długie ramię Vlada ????. . #handballaddicted . Since Monday in Poland we can train indoor. There are no official trainings anymore but these who are still in Kielce decided to meet up to chase a ball little bit. Check details at our instastory ????. . Best team ???????? . #gramyRAZEM #dawajDAWAJ #handball #training #team #together #Kielce Post udostępniony przez PGE VIVE Kielce (@kielcehandball) Maj 19, 2020 o 11:18 PDT It didn’t last too long as then majority of players took some vacations. But vacations or not, the training has to be done and Andreas was exercising a lot. How do you judge your form on the background to your teammates? I’m pretty strong at the gym and that’s nice – he admits – I could be better at running I guess, but actually it was very difficult to maintain form during the brake. Usually these programs are made for up to two months as the regular summer break lasts. This time it was more, so it left me in a little bit worse condition than last year regarding running. But I think I’m better in physical strength though. Our motor preparation coach Krzysztof Paluch gave to all of you special training programs few weeks ahead of preparations, didn’t he? Yes, he did, but actually when he sent it I already had my own program as I started much earlier. It was more or less the same in fact, my running was even harder. Did you have any period without training at all? When there was a time when it was forbidden to go out without a mask, even into forests, I did only the gym training. But no, I didn’t have days off, a week or two without training is not an option for me! "Money is an issue, but not the most important thing in the world. You know, it’s not only about the fact if I get all my money or not. For me it’s far more important how the situation is handled by the club. I really like the way Bert is fighting for the club. When the problems appeared he could have just quit. Instead of this, he is fighting. And as long as he is, I will as well." What is it that you don’t like in the preparations the most? I hate long distance running, like he is doing right now – we are sitting outside of the Hotel Binkowski where the team has got their grouping and some amateur runner is just passing by slowly behind the fence – I run at the same speed to be honest – he laughs – It is completely boring for me! I prefer 200 meters sprints, they are good for preparation. But now we run in the arena and it’s tough for me because instead of running 200 meters straight we turn around 10.000 times! It’s a different type of exhaustion! Usually players don’t like preparations. How about you? I love it, to be honest! – he admits enthusiastically while sharing his last week experiences – You know, after first days it was pretty exhausting at the gym and I though “Ufff.. I’m almost dying!”. But then I thought like “Wow, this is exactly the place where I want to be. There is nothing that I would rather do than training at the moment”. I love to exceed my limits, be with the guys, share the pain with them and play handball. For me it’s the greatest time of the year! In the end of the day you are exhausted but you feel you did your job well… … and still don’t have a pressure as there are no matches yet. Yes. There is a goal of course, but it’s so far away and you can just enjoy being professional and have fun! But the preparations would have been pointless if they didn’t lead to something. The season in Polish league will start at first weekend of September. Two weeks later there will come a time for the Champions League. Big emotions and even bigger changes as in the PGNiG Superliga there will be no play-offs and the matches will take place at weekends. In the Champions League we are coming back to the formula of 16 teams divided into 2 groups and the news is that games will be played on Wednesday and Thursday. Seems like the EHF wants to compete with the UEFA, as football Champions League plays on Tuesdays and Wednesdays. I don’t think that will be a problem – says Andi confidently – Football is so slow, you can watch it without following the whole game. Nowadays every household has got one TV and at least one laptop, smartphone, tablet or whatever, so people can watch two matches at the same time. And I think handball fans will watch handball anyway. The captain of Polish Champions is even happy about some fresh air that is filling in the structures of Polish and European handball. For me there is no difference if we play on Wednesday against Zabrze and Saturday against Szeged or if we play Flensburg on Wednesday and Puławy on Saturday. I think our spectators will be in the arena anyway and we will receive this great support we did last season. I’m not worried about the changes at all and honestly I welcome them because they give us a little bit more structure. I didn’t like it when I’m at home and I’m checking “Okay, is there any Champions League match today?”. You know I had to ask myself if there are matches even though I play in this competition – he laughs – It should be like “Okay, today is Wednesday, so there will be handball match”. On the other hand the Champions League got kind of closed again. Two groups, sixteen teams and almost the same matches as previously. Isn’t it boring a bit? Honestly, I feel the same. Champions League should be more special. In football it’s great as once you play against Juve, once against Barca, then Real, they face different teams all the time, travel around the world. When we play against same teams every year, at least twice, it gets a little bit less attractive. I would like to have more groups and more teams to mix them up a bit. Maybe we could do a system like in the European Championship that you have two group phases. First one with six teams, where for example three get promoted to the next round where they meet best teams from other group etc. That’s actually a great idea! Thank you – he answers humble and ask immediately laughing – Is this recorded? Ah yeah, compliments are always very welcome by Andreas Wolff. You know this theory of boxes in men’s head with a huge “nothing box” in the middle? I’m pretty sure instead of this Andi has got a big box with all compliments he has ever received from people and he keeps it in special cuddly area of his mind. And yes, I’m also sure he opens the box quite often. I just ignore it with a smile and continue with questions. What about changes in Polish league? For example there will be no play-offs this time. I have never played play-offs, so I can’t judge it really (laugh)! In Bundesliga play-offs wouldn’t be a good solution, that would be too exhausting! I think the system with a match and re-match is the most fair, because every match counts. There are not only two days that decide about the league. "I would like to have more groups and more teams in the Champions League to mix them up a bit. Maybe we could do a system like in the European Championship that you have two group phases. First one with six teams, where for example three get promoted to the next round where they meet best teams from other group etc." Another change is the rule about having at least two Polish players on the field during the whole game. First of all I think it’s a little bit weird, that they change the rules every year – Andi easily scores the middle of the target – Before there was a rule with the limit of 3 players out of the European Union. But okay, I think it’s a good idea for Polish national team. Some Polish talents, as we have in the team now like Czarek, Olej or Kaczka, will have a chance to play on early stages of their careers. It will let them progress very early. Thanks to the rule we have more players, we can rotate more and avoid injuries. I had a huge pleasure observing the team last season at training sessions. It seemed to me that the atmosphere was great and you built a really nice squad. But now, after watching you during first few trainings I think that the atmosphere is even better! It was a great atmosphere last year indeed, but it was different than this season. We had players like Julen, Kaczka – the old Kaczka (laugh), Siwy and they knew it was gonna be their last year in the club or even handball careers. This is something that always impacts your thinking. Young guys give 100% because they want to prove themselves worthy for the Champions League club. The old players know their job, they know what they need to do. It’s really refreshing for an older player to see some new talents coming to the team. You see the guy who is ten years younger running next to you and you think “Oh, no, I don’t want him to be faster than me!”. So I speed up! Andi straightens himself a little bit on the chair. Okay, they are all faster – he says with resignation but quickly looks for some bright sides – I am stronger though so it’s still fine – he admits now sitting proudly like the guy on the horse from the Old Spice commercial and trying to control his face muscles in order not to laugh. I like it that we focus on the future, maybe we will play in this squad for next four years. You know, the guys we had are great, they are great players, great persons, but it’s just a different mindset when you know you will not play with someone next season. Exactly like previous year we want to win every game and every competition. We have all the quality required to win both Polish league and Champions League. Talant is pretty ambitious this year, we want to follow his ideals. It will be tough, but for sure we are one of the top teams and what is important, our key players have already played together for a year now. We know each other a little bit better and this will help us. "It’s really refreshing for an older player to see some new talents coming to the team. You see the guy who is ten years younger running next to you and you think “Oh, no, I don’t want him to be faster than me!”. So I speed up!" What is your biggest motivation in the Champions League? I have never been in the Final4 tournament. We were on a good way last season and now I really want to have this experience! Which match are you looking forward the most? And why Flensburg? Andreas laughs cordially. Yeah, of course Flensburg, because it’s out first match that will decide the way we will go. We can make a great game and feel the wind in our wings for the future, build our confidence up. If we lose however, we might lose a little bit of confidence. We would like to prove to our opponents that we are not a team who can be beaten easily so that everyone respects us, that should be our goal. In addition, for me as former Kiel player this will be special to meet Flensburg fans, I am pretty sure they haven’t forgotten me – there is a special blink in Andi’s eyes which says that the topic definitely needs to be explored. I always had a special relation with the Flensburg fans. It’s pretty interesting how they will welcome me. My welcoming in Kiel last season was pretty warm and that was pretty exciting, but I think the one in Flensburg will be totally different. I hope for it a little bit, because I really like that special energy coming from the stands. If this interview had been taken in TV, the editor would just put here first verses of Chamillionaire song “Ridin’” as there is nothing that would complete this scene better. They are provoking all the times. During my first visit in Flensburg they were yelling at me and my teammates during the warmup so from the very beginning I had a thought in my mind “Okay, these are really interesting fans” – he laughs – You know, Flensburg is one of the strongest team in Bundesliga and maybe in the world, but their fans, let’s say are unusual. It’s a little bit like Kielce and Płock terms, isn’t it? Yes, exactly. The fans insult the players and this is the inferior side that insults superior one more. I think Kielce fans don’t go that far as Płock. I heard it when I was in Płock that Lijo and Kaczka had even their own chants. The fans were screaming “Come to me!” and I think that was a little bit too far. It’s the same in Flensburg. Kiel fans also don’t like Flensburg, but they don’t insult the fans and the players. Flensburg fans however have no boundaries! Where is the boundary then? I think that if you insult someone as the player, club’s member, this is fine, it’s a part of the rivalry. But if you go personal, then you cross the boundary. And what about Polish league? Excited to play against Płock this season? They are the biggest rival here! We had really tough match in Płock last season and a completely different one in Kielce. To be honest, I don’t think they showed 100% last time. My personal impression was that they didn’t come to Kielce to win, just to play a good match and see what happens. And nothing good happened for them so they gave up after 15 minutes. Maybe they were more focused on play-offs. I hope this season it will be a tough battle till the end. In the second part of the interview Andreas Wolff will tell about his second biggest passion, which is PlayStation. The captain of Polish Champions recently rediscovered the rivalry in cyberspace stepping into the world of professional e-sport. Part two of the interview at www.kielcehandball.pl coming soon.	cc/2021-04/en_middle_0036.json.gz/line854
__label__wiki	0.926447	0.926447	Home Posts tagged Taoiseach Micheal Martin News What's On WATCH: Talented Kilkenny teen hosts national event to mark World Children’s Day By Colin Bartley 19th November 2020 0 A Kilkenny teenager will take centre stage when she hosts a prestigious international event tomorrow. Katie McKenna (19) will host Child Talks tomorrow to mark World Children’s Day. The event organised by the Ombudsman for Children’s Office (OCO) is a ‘TED Talks’ style event that aims to have the voices of children and young people […] Lockdown 2: Taoiseach promises more financial supports for people and businesses as country moves under Level 5 restrictions By Kilkenny Now 19th October 2020 0 The Taoiseach tonight made a televised appeal to everyone to do everything they can to combat the spread of Covid-19. Speaking from Government Buildings, Micheál Martin confirmed the country is moving to a Level 5 lockdown, with some exceptions, from midnight on Wednesday night. A 5km travel limit will come into effect and most non-essential […] Government to bring in more restrictions tomorrow: Minister Higher Education Minister Simon Harris said the Government will act tomorrow with more Covid-19 restrictions. The former health minister said the action will “decisive and nationwide”. Minister Harris told RTÉ’s The Week in Politics: “It is clear now the virus is at such a level that a county by county approach is not sufficient.” Minister LATEST: Five further deaths and 611 new cases of virus, plans for on-the-spot fines for people in breach of Covid rules By Kilkenny Now 7th October 2020 0 Five more people have died after contracting the coronavirus as 611 new cases of Covid-19 were confirmed this evening. There overall death toll as a result of the virus now stands at 1,816. There are now 39,584 confirmed cases of Covid-19 across the country, according to the latest daily briefing from the National Public Health […] LATEST: 518 new cases of virus confirmed, Kilkenny and whole country to go under Level 3 lockdown – reports By Kilkenny Now 5th October 2020 Post a comment There has been no further coronavirus related deaths but 518 new cases of Covid-19 were confirmed this evening. The overall death toll as a result of the virus currently stands at 1,810 . There are now 38,549 confirmed cases of Covid-19 across the country, according to the latest daily briefing from the National Public Health […] Heart of the matter: Tender for second cath lab at regional hospital goes out this week By Colin Bartley 27th September 2020 0 The long-awaited second cath lab at our regional hospital will go to tender this week. And construction will get underway on the much-needed facility at University Hospital Waterford (UHC) by early 2021, Taoiseach Micheál Martin has confirmed. Mr Martin gave the assurances after Waterford Independent TD Matt Shanahan (pictured below) called for a review of […] LATEST: Three more deaths and 324 new cases of virus, Donegal to go under lockdown at midnight By Kilkenny Now 24th September 2020 Post a comment A further three people have died after contracting the coronavirus as 324 new cases of Covid-19 were confirmed this evening. It brings the overall death toll as a result fo the virus to 1,797. There are now 33,994 confirmed cases of Covid-19 across the country, according to the latest daily briefing from the National Public […] LATEST: Three more deaths and 357 new cases of virus, drama as entire Cabinet to self-isolate and Dáil adjourned By Kilkenny Now 15th September 2020 0 Three more people have died after contracting the coronavirus related deaths as 357 new cases of Covid-19 were confirmed this evening. It brings the overall death toll as a result of the virus to 1,787. There are now 31,549 confirmed cases of Covid-19 across the country. Kilkenny is among the counties to record new infections, […] LATEST: One further death and 255 new cases of virus, restrictions to remain in place until April 2021 One more person has died after contracting the coronavirus as 255 new cases of Covid-19 were confirmed this evening. It brings the overall death toll as a result of the virus to 1,784. There are now 30,985 confirmed cases of Covid-19 across the country. No new infections were recorded in Kilkenny, according to the latest […] MICHAEL WOLSEY: Why Minister Norma is the best girl in class By Michael Wolsey 9th September 2020 0 Norma Foley is the best pupil in Micheál Martin’s class. That’s not a great distinction, for they are an unruly bunch of under-achievers. They fight, talk behind the teacher’s back and tell tales out of school. And some of them never do their homework. But the Education Minister did her homework when it came to […]	cc/2021-04/en_middle_0036.json.gz/line855
__label__cc	0.65428	0.34572	Three Make-or-Break Factors for Tomorrow’s Start-ups Philip Anderson, INSEAD Alumni Fund Chaired Professor of Entrepreneurship \| December 8, 2016 The skillset necessary for entrepreneurial success is changing rapidly. There’s an irony to being a start-up founder these days. As the next generation of entrepreneurs emerges with disruptive designs on their respective industries, they’re entering a business world that has already been disrupted by start-ups that have gone before. The certainties of even five or ten years ago no longer apply. Because the rulebook is being extensively rewritten, we should expect start-up failure rates to remain high, even as the opportunities for the successful few have never been greater. Every smart entrepreneur has to forge his or her own pathway to success, but there are common factors to keep in mind. At last month’s INSEAD Forum in Singapore, I moderated a panel discussion on innovative entrepreneurship where INSEAD alums shared stories and advice from the trenches. Three core themes united their diverse comments. 1. Expertise is becoming less important than experimentation. It used to be that having a founder with deep industry knowledge and experience was a key differentiator for fledgling companies. Nowadays, like it or not, industry expertise has become commodified – you can easily buy or rent it. The skillset most essential to success these days has to do with experimentation: being able to learn by trial-and-error, adapt and move on to the next experiment faster than your competition. Panellist Will Klippgen ‘03D, an angel investor at Cocoon Capital and co-director of INSEADAlum Ventures, said, “It used to be about knowing a few things deeply, while it now seems that it is becoming just as important to learn a high number of things very fast. Learning has become a day-to-day activity.” Any experiment carries the risk of failure. The need for rapid and repeated experimentation raises the stakes considerably, on the principle of what mathematicians and statisticians call the “gambler’s ruin” – each roll of the dice increases the likelihood of financial wipe-out. To succeed, entrepreneurs will have to excel not only at learning from failure but also at designing experiments whose failure can be survived. 2. The gig economy makes for a daunting leadership learning curve. The commodification of expertise that I referred to above is largely the result of the gig economy. Digital technology makes it possible to tap a global talent pool for the exact competencies needed at any given time, rather than having to commit to nurturing a co-located team. “You have access to incredible technical expertise immediately and cost-effectively,” said panellist Cameron Stevens ‘06J, founder and CEO of online peer-to-peer lending platform Prodigy Finance. “Start-ups can match huge multinationals for depth of resource and technical knowledge without the cost base and bureaucracy.” But there are major challenges too. Without an enduring, personal, face-to-face connection with the other members of the venture team, inculcating a common corporate culture becomes no easy feat. As Stevens said, “Technology is still years away from enabling lifelike remote interactions. Distributed teams do not have the same cultural osmosis. They require a completely different leadership approach. Otherwise, you’re set up to fail.” Every business that scales up has to face the problem of fraying cultural cohesion. Manufacturer W.L. Gore & Associates, for example, famously caps the headcount for each of its factories at 150 to maintain an atmosphere where “everyone knows everyone”. The difference is that today’s start-ups are facing this problem from day one, thanks to the gig economy. If you’re in California, how do you win the time and attention of an expert in London who may be working with ten other clients? The challenge is making sure that person is integrated into your organisation even though he or she is not a full-fledged “team member”. 3. You can’t afford to ignore social impact. Panellist Xania Wong ’06D, CEO of Hong Kong-based recruiting platform JOBDOH, pointed out that in the developing world, entrepreneurs are filling in the social-welfare gaps left by corrupt and ineffective governments. The line between so-called “social enterprises” and conventional for-profit businesses is blurring. A new mind-set is gaining ground among start-up backers and conscious consumers: “A business ought to be financially sustainable, while incorporating social impact in its KPI,” according to Wong. When I advise entrepreneurs on their pitches these days – no matter what the project is – I always tell them to prepare a backup slide detailing what the social impact spill over of their business would be. Investors and corporations often have their own formal sustainability programmes to think of, and will want to verify that potential partners are on the same page. “I don’t know, I hadn’t thought of that” as a response to the social impact question isn’t likely to further your cause. Additionally, how your venture affects society may influence how the government views you, especially now that populism is on the rise in the U.S. and elsewhere. If you’re offering a fully automated solution with neither the potential to grow an employee base nor a net-positive impact on the community, you may be taxed differently than a business that is seen as a social asset. The funding runway If there is one overarching insight I took away from the panel, it is that a start-up’s possible worth can no longer be measured by the funding it has managed to secure, or the deep-pocketed companies it’s worked with. External support can lengthen the runway for a start-up, but it will remain earthbound without agility in adaptation and the other newly essential skills mentioned above. Aloke Bajpai ‘05J, founder and CEO of leading Indian travel website Ixigo, summed it up well: “The fact that many hyper-funded start-ups are currently struggling comes as redemption for the 90 percent of start-ups out there that are daring to dream despite limited resources. There is still no price or substitute for that courage, irrationality, passion, perseverance and intuition about the market’s evolution.” Philip Anderson is the INSEAD Alumni Fund Chaired Professor of Entrepreneurship and Professor of Entrepreneurship at INSEAD. He is also the Academic Director of the Rudolf and Valerie Maag INSEAD Centre for Entrepreneurship. Follow INSEAD Knowledge on Twitter and Facebook Longer, Better Lives in the Sharing Economy How Successful Start-up Teams Allocate Roles Learning the Moves of Successful Startups Dianas, 08.12.2016 at 02.32 pm Company culture - a notion to be challenged I believe the very idea of company culture is going to be challenged very soon. Is it mandatory for all organisation members to adhere to the same principles and values? Can there be a dialogue even when team members are not bonded by the same creed? Could that look like a miniature nowadays society, when people of conflicting beliefs have to come to terms, somehow? That might be an interesting experiment, IMHO. Also, provided that the manager understands the importance of replacing physical workspace with software, things might work out just fine for the startup with employees in different geographies and of diverse backgrounds. There is one infograph that gives a very good idea of what it takes to successfully replace the desk job with the remote job: https://www.hubgets.com/blog/infographic-5-lessons-collaboration-5-ultra-successful-remote-teams/ MC, 12.12.2016 at 09.46 am CHRO, Exec. Advisor, CSO 1) Creating a Make Believe People Culture 2) Poor or No REAL in-House Leaders AND HR leadership and structure 3) VCs and investors get too close to daily operations and too unrealistic on Long Term profits 4) Diversity and Inclusion hiring, from the start- not just having all the guys/ (less gals) from the VCs make their referrals, key employees 5) Sustainability Factors 6) What are you doing to really change the game/world 6) Exit Strategy - been here, been there, done that in Silicon Valley, BioTech Bay and now HOT LaLaLand of Silicon Beach. CY, 09.02.2017 at 04.06 am Expertise & Experimentation "Expertise is becoming less important than experimentation." Humbly I'd say whilst experimentation is very important in not just entrepreneurship but also the pursuit of knowledge, and in pushing the frontier of knowledge, "Expertise" is no less important. Expertise is a reflection of the depth of accumulated domain knowledge. While "experimentation" is a methodology, the Scientific Method in essence. If we simply pause and reflect a little, Lean Startup/Agile and Design Thinking are mere Scientific Method in disguise. Domain knowledge and expertise are the necessary albeit insufficient conditions for any successful startups. But "Expertise" and "Experimentation" are not mutually exclusive at all. Philip Anderson - INSEAD, 12.02.2017 at 01.14 pm Thanks for your comment. I agree that both the ability to experiment and expertise are important and are not mutually exclusive; without domain knowledge, you can’t think of worthwhile hypotheses to test. The thought coming out of the panel is that INSEAD and most business schools have been so focused on domain expertise that we may not be spending enough time building adaptive capacity. Perhaps we need to strike more of a balance in our entrepreneurship electives by teaching our students in a more rigorous way how to experiment—sift information, connect the dots, detect a pattern, devise quick hypotheses tests, objectively interpret the data while overcoming predictable biases, and use new insights to adapt and move forward. INSEAD is blessed with an excellent Decision Science area that shows people how to improve their judgment and decision-making under uncertainty. We’re working in the new entrepreneurship capstone course to give people more practical knowhow and experience in experimenting, so they can get more out of the expertise they have brought to INSEAD and acquired during their MBA year. Expertise & Experimentation + Adaptive Capacity Thanks for providing additional context and insights. Yes, experts can over time be “boxed in” by their own expertise, resulting in habitual thinking in the same old box (idea, model, and paradigm). Hence, as you rightly pointed out, the need for building “adaptive capacity,” for the purpose of constructing new “boxes”. Keenly looking forward to learning more about the new entrepreneurship capstone course. ps: Max Planck had some rather “colorful” words vis-a-vis the "boxed-in disease" among scientists as well, which was understandable and particularly so during the formative years of Quantum Physics: “Science advances one funeral at a time.” Philip Anderson is the INSEAD Alumni Fund Chaired Professor of Entrepreneurship and Professor of Entrepreneurship at INSEAD.	cc/2021-04/en_middle_0036.json.gz/line857
__label__cc	0.584915	0.415085	« Stanley/Black and Decker to buy Irwin tools! Hammers. Hammers! Hammers? » The history of the hammer from its prehistoric beginnings. Published June 30, 2017 \| By Langs_A The modern day hammer has had an incredible evolution since its origins when man needed to hit and smash shells or bones to get food. Initially. I thought a post about the evolution of the hammer may be interesting, but I’ve found that hammers are much greater than just a hand tool, they are literally the great grandfather of every tool ever made! The basics; A hammer is a tool for striking another object or substance, whether wood, metal, stone or anything else. The modern day hammer has many variations, looks and sizes. Creating an extremely versatile tool. Then man created the hammer; Archaeologists have now discovered the first appearance of a tool used as a hammer was 3.3 million years ago (149 found in Lake Turkana in northern Kenya in 2015) when a “hammer stone” was used to splinter more brittle stones like flint, into cutting and killing tools. After they began to perfect their technique, they formed and shaped axes, knives, then more intricate arrow heads and spear heads. Still later these proto-humans used the formed shards into carving tools for wood, to break open animal skulls, bones, shells and even make jewellery. This embryonic hammer, was little more than a heavy elliptical stone between 300 grams to a kilo smoothly formed at the bottom of a river bed, or from the sea. The stone was used to hit an object, which was sitting on a large flat stone below it, like an anvil. If a more intricate point was needed, the stone hammer would be replaced with a smaller stone, bones, ivory and antlers using more finesse for finishing the new cutting tools. Then around 30,000 BC, an incredible 3.27 million years later. The next stage of the hammer’s evolution came into being. The addition of a handle; the stone being tied to either a piece of wood or bone with leather, vine, sinew, hair or similar substance tying the head to the handle. Creating the more familiar modern day looking hammer, similar to those made by native americans in the 1800’s. This addition may not seem a big one, but it enabled the user to have more control over what they were hitting, and the accuracy of the strike. It meant that this new hammer could be used for more intricate work and meant the creation of a more artisan society. With the advent of the handle this meant the hammers evolution to what we know today advanced exponentially. Having a handle also allowed the user to have less accidents with the wielded tool. Then hammer’s next advance was the coming of metal and the bronze age. Around 3,000 BC, 27,000 years after the last important update of the hammer. Hammer heads were forged with bronze, making them more durable as far as binding them was concerned. The first hammer heads were probably melted bronze bound with similar bindings to stones, and evolved with the onset of forging and casting processes. This allowed a hole to be put through the bronze to take the handle. With the invention of forges and casting other copper and bronze products were made including nails. Bronze age hammer face. The hammer was fitted on to a piece of wood or bone, then used as a hammer. Although iron was around in it’s raw form since the beginning of the bronze age, with meteroic iron. Which was found and used for tools such as hammers. It wasn’t until 1200 BC that iron was properly extracted and used to make tools and weapons. Making the old bronze hammers and equipment obsolete. Hammers started to evolve their shapes at this point in their history. Having round faces, square faces, cutting edges, reliefs, and so on. Among the new shapes of hammer the claw head was created for recovering bent or damaged nails for re-smelting. Also meaning you could reuse the precious iron or bronze nail. Iron age (post medieval) hammer head. The discovery of Steel was the advent of modern day hammers and tools. From the unrecognisable embryonic eliptical stone of 3million years previously. Originally created around 1800 BC, but spread across the world properly in the 11th century. The process was refined and augmented by the 1500’s with the birth of today’s standard of steel making. From 1500’s on the evolution of industry came the evolution of the hammer, during which the refining of hammer types and their nuances was developed and experimented with to make a different hammer that was ideal for each job. Coachbuilding, house building, brick layers,blacksmiths, masons, miners and any number of other jobs. A copy of a steel headed and handled hammer. (circa 1760) The Hammer’s produced next were “forged” by the industrial revolution starting in 1760 and 1870 the explosion in industry and the need for tools to repair and maintain the new machinery created. Also mass product of hammers, made them all similar and had to be produced to the same standards. These processes also meant that wood, rubber, copper, lead, brass, hide and broze hammers and mallets were easier to make and made more popular. With these new industries came bespoke hammer product such as larger moving and slogging equipment. With the coming of the new century in the 1900’s came the invention of new materials; Bakelite, casin, and new metal alloys mean hammer faces and handles could be used in a new and different ways. With the development of physics to explain why a hammer works and man has learned to make it more efficient at its job, and so the development of the hammer has continued to become advance, along with its aesthetics. Leading to the modern hammer we see today, made by companies like Stanley, Thor and Estwing, all founded in the early 1920’s. These commercial companies essentially creating the sophisticated hammers the we still see today, from the invention of massive powered steam or electric hammers, to the smallest archeological or surveyor’s hammers. The modern claw hammer. Mass produced since the 1920’s In the next post I shall go through the best modern hammers, who makes them and where to buy them. Posted in hammers, Hand tools 15 Responses to The history of the hammer from its prehistoric beginnings.	cc/2021-04/en_middle_0036.json.gz/line861
__label__wiki	0.847437	0.847437	Schubert: Symphonies Nos. 1-9 - Les Musiciens du Louvre (on period instruments) / Minkowski, Marc V5299 Katalognummer 822186052990 EAN 4CD Format 2012 Utgivelsesår Les Musiciens du Louvre (on period instruments) \| Minkowski, Marc Minkowski, Marc Les Musiciens du Louvre Schubert: Symphony No. 1 in D major, D82 Schubert: Symphony No. 2 in B flat major, D125 Schubert: Symphony No. 3 in D major, D200 Schubert: Symphony No. 4 in C minor, D417 'Tragic' Schubert: Symphony No. 6 in C major, D589 Schubert: Symphony No. 8 in B minor, D759 'Unfinished' Schubert: Symphony No. 9 in C major, D944 'The Great' Following the extremely successful recording of Haydn complete London Symphonies released in 2010, Marc Minkowski, Naïve and the Wiener Konzerthaus set up a new project, even more ambitious although similar in form: to perform for the Viennese audience and record the complete symphonies of Schubert in the same week, in March this year. 2012 marks the 30th anniversary of Les Musiciens du Louvre Grenoble. Major concerts will take place in Paris this Autumn to celebrate this event. This 4-CD set on period instruments sheds a new light on all the Symphonies, some not as highly considered as perhaps they should be. Les Musiciens du Louvre Grenoble use instruments of the Classical era, laid out according to Viennese tradition, with the violins on either side of the conductor and the double basses in a line facing him. The oboe too is of Viennese manufacture: its highly idiosyncratic bore produces a sound, at once nasal and tender, that is immediately recognisable – indeed, despite developments in instrument making and the multiplication of keys, the modern version of this instrument is still not so very far removed from the oboe that Schubert knew. Four double basses are used in general but only two for the Fifth Symphony, which is written in a more central tessitura and dispenses with clarinets, trumpets, and timpani. ‘In the “Great C major”, on the other hand,’ explains Marc Minkowski, ‘Schubert’s ambitions recall, relatively speaking, those of Haydn in The Creation or Beethoven in the Ninth Symphony. That’s why I chose to deploy five basses and to double the first flute and oboe parts and the second clarinet and bassoon parts: the use of three instruments per section allows us to obtain that organ sonority that was later to define the Bruckner rchestra, whereas the woodwind, in the early symphonies, sound like a pastoral group. When all is said and done, the key word for all this music is melancholy, even at the height of virtuosity – and goodness knows that these works, more ideal than practical, remain behind their apparent simplicity very risky to bring off in performance. Schubert wrote with genius for the orchestra, but his thought, much more than that of Mozart or Beethoven, was situated outside reality, in the tumultuous imagination of a young – sometimes very young – man, at the frontiers of the possible.’ Minkowski takes a surprisingly conventional view of these pieces, though his performances, recorded 'live' in Vienna's Konzerthaus, are none the worse for that...impressive performances, greatly aided by the skilful playing of Les Musiciens du Louvre Grenoble and their admirable first oboe...This set can take its place among the very best of Schubert Symphony cycles. BBC ***** Laster kommentarer ... ×Tips en venn Schubert: Symphonies Nos. 1-9 Les Musiciens du Louvre (on period instruments) / Minkowski, Marc Send tipset til (din venns e-postadresse) Din e-postadresse (IP: 3.227.247.17) Din kommentar (valgfritt) Minst et par ord, dersom du skriver noe Sender, vennligst vent .. Avbryt	cc/2021-04/en_middle_0036.json.gz/line864
__label__wiki	0.77075	0.77075	UTEP Men’s Basketball Recruiting Radar Adrian Broaddus Photo by David Becker/Getty Images Recruiting season is heating up for the UTEP men’s basketball team, as Rodney Terry and his staff are making the extra push for their 2018 recruiting class. The last day for players to sign the National Letter of Intent is May 16, which means a swarm of offers and recruits coming to visit El Paso will likely take place in the coming weeks. One thing is for sure, by the looks of the incoming recruits that Terry and staff are actively seeking out, this new coaching staff is aspiring high with certain players. Here are the current recruits UTEP has on their board: Efe Odigie (Center / 6-9 / 275) Offers: UTEP, Fresno State, Texas State, Arkansas State Status: Signed NLI Miner fans should be happy that the first UTEP signee of 2018 will be center Efe Odigie. This man is a tank at 275-pounds and resembles a beefy big man like Cedrick Lang. Coming out of Houston, Odigie played his high school basketball career with Pro Vision Academy before being recruited by Terry and staff to go to Fresno State. With the announcement of Terry being hired as the UTEP head coach, Odigie graciously followed the staff and is all set for his time here at UTEP. The Miners will desperately need his inside presence down low, as the team ranked in the bottom three of the conference in both offensive and defensive rebounding categories. With center Matt Willms graduating and the announcement of Tirus Smith departing from the team, Odigie might be able to fill a necessary inside role immediately with the team. Watch what the big man can do here. Isaac Likekele (Guard / 6-4 / 195) Mansfield, TX (Three-Star recruit) Offers: Texas Tech, Oklahoma State, UTEP, Ole Miss, Marquette, Purdue, Fresno State Status: On visit Ranked in the top-10 of all Texas basketball recruits, Isaac Likekele told 24/7 Sports that he’s narrowed down his top three schools to Texas Tech, Oklahoma State and UTEP. Let’s just say, if UTEP were to beat out two Big 12 schools and snatch Likekele, it would be their best signee by far. Watch his film here. What makes Likekele so special is his hybrid ability at the guard spot, where he can shoot the ball well, drive to the paint or facilitate the ball. He’s coming off a 5A state title with Mansfield Timberview and was named MVP of the Whataburger Tournament in 2017. Currently, he’s on his visit to El Paso, so Terry will have to recruit him hard to have him stay in El Paso. His priorities in choosing a school are playing time, which UTEP will likely offer him, and a family atmosphere, according to 24/7 Sports. “I’ve been told a lot, that it’s a historic program and they’re the No. 1 Texas basketball school historically and all that, but other than that I don’t know too much about it so I’m going to go out there and see what it has to offer.” -Likekele told 24/7 Sports. Nigel Hawkins (Shooting Guard / 6-2 / 175) Cypress Falls-Houston, TX (Three-Star recruit) Offers: Va. Tech, Texas A&M, South Florida, Houston, Rice, UTEP Nigel Hawkins is another Texas state championship holder after he helped Cypress Falls win a 6A title. He’s ranked in the top-25 of all Texas guards and brings quickness, a good shot and strong defense to the table. Texas A&M just offered Hawkins and he recently came back from visiting Virginia Tech, so the Miners are dealing with some hefty competition. He’s currently joining Likekele on his official visit with the university. The simple pitch Terry has to throw at Hawkins is he will get substantial playing time in a guard-heavy system. Adding Hawkins can also strengthen UTEP’s scoring, which ranked dead last in C-USA last season at 67.5 points per game. Neftali Alvarez (Guard / 6-1 / 175) Miami Christian (Three-Star recruit) Offers: Wichita State, Arkansas State, UTEP, Akron, Dayton, Colorado State, Ga. Tech Status: Offered The Puerto Rican native in Neftali Alvarez is a highly sought out three-star recruit out of Florida who has yet to commit anywhere. He’s been recruited all over, with official visits from Akron, Wichita State and Arkansas State in the fall. However, he’s continued to hold back his official commit, possibly looking for a better opportunity. I’m sure Terry would love to get Alvarez on a plane and fly him to El Paso and visit the school. Even former Miner hooper and Puerto Rican native Filiberto Rivera jumped on the train to help offer some words of advice to play at UTEP via Twitter. Madiaw Niang (Small Forward / 6-9 / 200) DME Sports Academy (Two-Star recruit) Offers: FAU, Long Beach State, UTEP, FIU, Coastal Carolina Coming out of Senegal, Madiaw Naing had a breakout senior season for DME Sports Academy as a multi-versed small forward. He’s dominant on transition plays, brings length that makes him tough defensively and has nice handles for a small forward. His Twitter profile has been all UTEP as of late, so possibly Terry capitalized on this underrated international athlete. And hey, the athletic department is widely known for taking in international students and breeding them through the diverse UTEP system. Filed Under: Rodney Terry, UTEP Athletics, utep basketball, UTEP basketball recruits Categories: Featured (Carousel), Sports, SportsTalk, UTEP	cc/2021-04/en_middle_0036.json.gz/line869
__label__cc	0.518457	0.481543	Advanced Networking, 6 credits (TDTS21) Avancerade nätverk, 6 hp Course starting semester Course literature Course examination Main field of study Computer Science and Engineering Computer Science Programme course Niklas Carlsson Director of studies or equivalent Patrick Lambrix Available for exchange students Course offered for Timetable module 6MICS Computer Science, Master's Programme 2 (Spring 2021) 1, 2 1, 1 English Linköping v 6MICS Computer Science, Master's Programme (Computer Networks, Distributed Systemas and Security) 2 (Spring 2021) 1, 2 1, 1 English Linköping v 6CDDD Computer Science and Engineering, M Sc in Engineering 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CDDD Computer Science and Engineering, M Sc in Engineering (Communication) 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CDDD Computer Science and Engineering, M Sc in Engineering (Computer Systems Architecture) 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CDDD Computer Science and Engineering, M Sc in Engineering (Secure Systems) 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CITE Information Technology, M Sc in Engineering 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CITE Information Technology, M Sc in Engineering (Communication) 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CITE Information Technology, M Sc in Engineering (Computer Systems Architecture) 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CITE Information Technology, M Sc in Engineering (Secure Systems) 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CMJU Computer Science and Software Engineering, M Sc in Engineering 8 (Spring 2021) 1, 2 1, 1 English Linköping v 6CMJU Computer Science and Software Engineering, M Sc in Engineering (Secure Systems) 8 (Spring 2021) 1, 2 1, 1 English Linköping v Computer Science and Engineering, Computer Science Advancement level Master's Programme in Computer Science Computer Science and Engineering, M Sc in Engineering Information Technology, M Sc in Engineering Computer Science and Software Engineering, M Sc in Engineering Basic computer networks course. (For LiU students, this normally corresponds to having taken TDTS06, TDDE35/TDDD93, TDTS11, eller TDTS04.) Using a combination of theory and exploration of real data, participants will gain a deeper understanding of modern computer networks, applications, and network services. The course complements the basic computer network courses both in depth and in breadth and will focus on current "hot topics" within the computer network domain. Participants successfully completing the course will have experience and be able to: explain, in detail, a wide range of technologies used to build data networks; explain using concrete examples fundamental network design principles and scalability tradeoffs; predict and explain how different networking technologies at the same or different layers interact and affect each other in a large-scale system; critically evaluate network technologies with respect to system requirements, based on information from current research and technical documentation; design and perform targeted experiments to critically evaluate network technologies, applications, and services; apply basic system models and analysis methods to analyze distributed systems and networks; plan and conduct an extensive study of an identified problem within a selected area of technology, including integrating knowledge from multiple sources such as current research, technical documentation and experiments from real data sources (in some cases collected by the students themselves); generalize and synthesize information from multiple sources (and types of sources) in the computer network area to form original and well-motivated conclusions; and based on an in-depth study, present and explain (both written and orally) findings within a selected area of technology, to an audience with similar general knowledge of computer networks. The precise contents of the course vary slightly from year to year, to keep up with developments in the area, and to focus on currently "hot topics" (e.g., SDN, cloud, VR over network, ML-based traffic classification/detection ...). Recurring topics include: Fundamental properties of computer networks (e.g., Power laws, rich-gets-richer); Scalable systems and designs (e.g., hierarchical vs. flat designs; layered designs); Protocol interactions (e.g., between common protocols such as HTTP, TCP, IP, Ethernet, as well as more application/domain specific protocols), Measurement, modeling and analysis methods using real network data; Important modern computer architectures (e.g., cloud services such as EC2, CDNs, the Internet routing architecture itself, smart grids, and social networks). Teaching and working methods The course consists of both theory (lectures, seminars, and paper discussions) and practical hands-on training and exploration (project). The underlying theme of the course is to use real data and experiments to understand network infrastructures and their services. The course has a written final exam. The project should result in a written report, should be presented in a seminar during which the students will act as both presenters and opponents (evaluating and providing each other with feedback, such as to improve the reports and projects). The course runs over the entire spring semester. TEN1 Written examination U, 3, 4, 5 2.5 credits PRA1 Project assignment with oral presentation U, G 3.5 credits Active participation in the seminars is compulsory. Four-grade scale, LiU, U, 3, 4, 5 Supplementary courses: Thesis or individual project. About teaching and examination language The teaching language is presented in the Overview tab for each course. The examination language relates to the teaching language as follows: If teaching language is Swedish, the course as a whole or in large parts, is taught in Swedish. Please note that although teaching language is Swedish, parts of the course could be given in English. Examination language is Swedish. If teaching language is Swedish/English, the course as a whole will be taught in English if students without prior knowledge of the Swedish language participate. Examination language is Swedish or English (depending on teaching language). If teaching language is English, the course as a whole is taught in English. Examination language is English. The course is conducted in a manner where both men's and women's experience and knowledge are made visible and developed. The planning and implementation of a course should correspond to the course syllabus. The course evaluation should therefore be conducted with the course syllabus as a starting point. Course website and other links http://www.ida.liu.se/~TDTS21/index.en.shtml Education components Preliminary scheduled hours: 30 h Recommended self-study hours: 130 h Forskningsrapporter och annan litteratur (tillgänglig online) som identifieras/presenteras under kursen. Avancerade nätverk TDTS21 2021 Spring semester Determined by Board of Studies for Computer Science and Media Technology Date determined LiU-2020-03429 Download course literature list as PDF A syllabus must be established for each course. The syllabus specifies the aim and contents of the course, and the prior knowledge that a student must have in order to be able to benefit from the course. Timetabling Courses are timetabled after a decision has been made for this course concerning its assignment to a timetable module. Interrupting a course The vice-chancellor’s decision concerning regulations for registration, deregistration and reporting results (Dnr LiU-2015-01241) states that interruptions in study are to be recorded in Ladok. Thus, all students who do not participate in a course for which they have registered must record the interruption, such that the registration on the course can be removed. Deregistration from a course is carried out using a web-based form: https://www.lith.liu.se/for-studenter/kurskomplettering?l=en. Cancelled courses Courses with few participants (fewer than 10) may be cancelled or organised in a manner that differs from that stated in the course syllabus. The Dean is to deliberate and decide whether a course is to be cancelled or changed from the course syllabus. Guidelines relating to examinations and examiners For details, see Guidelines for education and examination for first-cycle and second-cycle education at Linköping University, Dnr LiU-2019-00920 (http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592). An examiner must be employed as a teacher at LiU according to the LiU Regulations for Appointments, Dnr LiU-2017-03931 (https://styrdokument.liu.se/Regelsamling/VisaBeslut/622784). For courses in second-cycle, the following teachers can be appointed as examiner: Professor (including Adjunct and Visiting Professor), Associate Professor (including Adjunct), Senior Lecturer (including Adjunct and Visiting Senior Lecturer), Research Fellow, or Postdoc. For courses in first-cycle, Assistant Lecturer (including Adjunct and Visiting Assistant Lecturer) can also be appointed as examiner in addition to those listed for second-cycle courses. In exceptional cases, a Part-time Lecturer can also be appointed as an examiner at both first- and second cycle, see Delegation of authority for the Board of Faculty of Science and Engineering. Forms of examination Principles for examination Written and oral examinations and digital and computer-based examinations are held at least three times a year: once immediately after the end of the course, once in August, and once (usually) in one of the re-examination periods. Examinations held at other times are to follow a decision of the board of studies. Principles for examination scheduling for courses that follow the study periods: courses given in VT1 are examined for the first time in March, with re-examination in June and August courses given in VT2 are examined for the first time in May, with re-examination in August and October courses given in HT1 are examined for the first time in October, with re-examination in January and August courses given in HT2 are examined for the first time in January, with re-examination in March and in August. The examination schedule is based on the structure of timetable modules, but there may be deviations from this, mainly in the case of courses that are studied and examined for several programmes and in lower grades (i.e. 1 and 2). Examinations for courses that the board of studies has decided are to be held in alternate years are held three times during the school year in which the course is given according to the principles stated above. Examinations for courses that are cancelled or rescheduled such that they are not given in one or several years are held three times during the year that immediately follows the course, with examination scheduling that corresponds to the scheduling that was in force before the course was cancelled or rescheduled. When a course is given for the last time, the regular examination and two re-examinations will be offered. Thereafter, examinations are phased out by offering three examinations during the following academic year at the same times as the examinations in any substitute course. If there is no substitute course, three examinations will be offered during re-examination periods during the following academic year. Other examination times are decided by the board of studies. In all cases above, the examination is also offered one more time during the academic year after the following, unless the board of studies decides otherwise. If a course is given during several periods of the year (for programmes, or on different occasions for different programmes) the board or boards of studies determine together the scheduling and frequency of re-examination occasions. Retakes of other forms of examination Regulations concerning retakes of other forms of examination than written examinations and digital and computer-based examinations are given in the LiU guidelines for examinations and examiners, http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592. Registration for examination Until January 31 2021, the following applies according to previous guidelines: In order to take an written, digital or computer-based examination student must register in advance at the Student Portal during the registration period, which opens 30 days before the date of the examination and closes 10 days before it. Candidates are informed of the location of the examination by email, four days in advance. Students who have not registered for an examination run the risk of being refused admittance to the examination, if space is not available. From February 1 2021, new guidelines applies for registration for written, digital or computer-based examination, Dnr LiU-2020-02033 (https://styrdokument.liu.se/Regelsamling/VisaBeslut/622682). Symbols used in the examination registration system: ** denotes that the examination is being given for the penultimate time. * denotes that the examination is being given for the last time. Code of conduct for students during examinations Details are given in a decision in the university’s rule book: http://styrdokument.liu.se/Regelsamling/VisaBeslut/622682. Retakes for higher grade Students at the Institute of Technology at LiU have the right to retake written examinations and digital and computer-based examinations in an attempt to achieve a higher grade. This is valid for all examination components with code “TEN”, “DIT” and "DAT". The same right may not be exercised for other examination components, unless otherwise specified in the course syllabus. A retake is not possible on courses that are included in an issued degree diploma. The grades that are preferably to be used are Fail (U), Pass (3), Pass not without distinction (4) and Pass with distinction (5). Grades U, 3, 4, 5 are to be awarded for courses that have written or digital examinations. Grades Fail (U) and Pass (G) may be awarded for courses with a large degree of practical components such as laboratory work, project work and group work. Grades Fail (U) and Pass (G) are to be used for degree projects and other independent work. Examination components The following examination components and associated module codes are used at the Faculty of Science and Engineering: Grades U, 3, 4, 5 are to be awarded for written examinations (TEN) and digital examinations (DIT). Examination components for which the grades Fail (U) and Pass (G) may be awarded are laboratory work (LAB), project work (PRA), preparatory written examination (KTR), digital preparatory written examination (DIK), oral examination (MUN), computer-based examination (DAT), home assignment (HEM), and assignment (UPG). Students receive grades either Fail (U) or Pass (G) for other examination components in which the examination criteria are satisfied principally through active attendance such as tutorial group (BAS) or examination item (MOM). Grades Fail (U) and Pass (G) are to be used for the examination components Opposition (OPPO) and Attendance at thesis presentation (AUSK) (i.e. part of the degree project). In general, the following applies: Mandatory course components must be scored and given a module code. Examination components that are not scored, cannot be mandatory. Hence, it is voluntary to participate in these examinations, and the voluntariness must be clearly stated. Additionally, if there are any associated conditions to the examination component, these must be clearly stated as well. For courses with more than one examination component with grades U,3,4,5, it shall be clearly stated how the final grade is weighted. For mandatory components, the following applies: If special circumstances prevail, and if it is possible with consideration of the nature of the compulsory component, the examiner may decide to replace the compulsory component with another equivalent component. (In accordance with the LiU Guidelines for education and examination for first-cycle and second-cycle education at Linköping University, http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592). For written examinations, the following applies: If the LiU coordinator for students with disabilities has granted a student the right to an adapted examination for a written examination in an examination hall, the student has the right to it. If the coordinator has instead recommended for the student an adapted examination or alternative form of examination, the examiner may grant this if the examiner assesses that it is possible, based on consideration of the course objectives. (In accordance with the LiU Guidelines for education and examination for first-cycle and second-cycle education at Linköping University, http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592). Reporting of examination results The examination results for a student are reported at the relevant department. For examinations that involve the writing of reports, in cases in which it can be assumed that the student has had access to other sources (such as during project work, writing essays, etc.), the material submitted must be prepared in accordance with principles for acceptable practice when referring to sources (references or quotations for which the source is specified) when the text, images, ideas, data, etc. of other people are used. 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__label__cc	0.720812	0.279188	Tell Me How I Die (2016) M4ufree Movies - Watch Movie Tell Me How I Die (2016) Online Starring: Nathan Kress, Virginia Gardner, Kirby Bliss Blanton, Ryan Higa Director: D J Viola Storyline: Tell Me How I Die (2016) When a group of college students take part in a clinical drug trial, an unexpected side effect of the experimental medicine gives them terrifying visions of their own deaths...which begin to come true. As they scramble to escape their fate, they discover that the killer is among them and shares their ability to see the future only he seems to be one step ahead of their efforts to survive. # Tags: 2019 Movies Nathan Kress Virginia Gardner Kirby Bliss Blanton Ryan Higa Rogue One: A St From Lucasfilm comes the first of the Star Wars standalone films, "Rogue One: A Star Wars Story," an all-new epic adventure. In a time of conflict, a group of unlikely heroes band together on a mission to steal the plans to the Death Star, Blind Dating (2 Blind Dating (2006) Blind Dating (2006) U.S.-based Leeza works in Dr. Perkins Medical Research Facility. Her mother, originally from India, was single when she arrived in America, and fell in with a Caucasian male as he looked like a movie star. Her dreams were shattere Pop! The Scienc Pop! The Science of Bubbles (2013) Pop! The Science of Bubbles (2013) N/A Saving Face (20 Saving Face (2004) Saving Face (2004) In Manhattan, the brilliant Chinese-American lesbian surgeon Wil is surprised by the arrival of her forty-eight year old widow mother to her apartment. Ma was banished from Flushing, Queens, when her father discovered that she was Gettin In (2012 Gettin In (2012) Gettin In (2012) A trio of clueless minors embark on a quest to get into the local bar, in the hopes of scoring with the opposite sex. The Truth (2019 The Truth (2019) The Truth (2019) A stormy reunion between scriptwriter Lumir with her famous mother and actress, Fabienne, against the backdrop of Fabienne's autobiographic book and her latest role in a Sci-Fi picture as a mother who never grows old. Bran Nue Dae (2 Bran Nue Dae (2009) Bran Nue Dae (2009) In the Summer of 1969 a young man is filled with the life of the idyllic old pearling port Broome - fishing, hanging out with his mates and his girl. However his mother returns him to the religious mission for further schooling. A One Dollar Too One Dollar Too Many (1968) One Dollar Too Many (1968) Suave gambler Clay Watson, cocky sharpshooter Moses Lang, and wily thespian Edwin Kean are a trio of criminals in the Old West. The motley threesome are forced to form an uneasy alliance in order to find $400,000 dollars in Body Slam (1986 Body Slam (1986) Body Slam (1986) M. Harry Smilac is a down-on-his-luck music manager who is having a hard time attracting talent and booking gigs for his band, Kicks (The most recent of the gigs is a Dairy Queen opening!!). When making arrangements for a campaign fu Dororo (2007) In the year 3048, the wounded Lord Kagemitsu Daigo proposes a deal to rule the whole world to forty-eight demons in their sealed temple. In return, the demons ask forty-eight parts of the body of his unborn son. When the mutilated baby Behemoth (2011) Behemoth (2011) In the small Ascension, the constructor Thomas Walsh is working with his team at the Mount Lincoln. Out of the blue, there are tremors and the branch of the tree fall over Thomas' employee and breaks his leg. He brings his truck and f The Orange Man The Orange Man (2015) The Orange Man (2015) In 1987 a disillusioned door to door orange salesman horrifically murders his first victim. Move forward 27 years and a land developer is buying an orange grove. He and his 3 friends plan a fishing trip to get his head around th Short Time (199 Short Time (1990) Short Time (1990) Burt Simpson (Dabney Coleman) is nearing retirement and he finds that he has a disease that will kill him within days. He then finds that his life insurance only pays off if he is killed in the line of duty. In order to leave someth The Perils of P The Perils of Pauline (1947) The Perils of Pauline (1947) Funloving Pearl White, working in a garment sweatshop, gets her big chance when she "opens" for a delayed Shakespeare play...with a comic vaudeville performance. Her brief stage career leads her into those &quot A Price Above R A Price Above Rubies (1998) A Price Above Rubies (1998) About a young woman who is married to a devout Jew and the problems that trouble their marriage because of the woman wanting something more out of her life Baazigar (1993) Baazigar (1993) A poor but ambitious young man Ajay Sharma is a devoted son to his widowed, traumatized, amnesiac mother. He leaves home for Bombay to fulfill the mysterious promise he made to himself and his mother. On the way he gets a lift from hi DaphnÃ© ou la DaphnÃ© ou la belle plante (2015) DaphnÃ© ou la belle plante (2015) As any pretty plant, Daphne buds, opens, fills with fragrance and loses leaves. But is never allowed pick. Combining animation and continuous shooting, Daphne or the lovely specimen is a documentary painting the po Spoils of War ( Spoils of War (2009) Spoils of War (2009) Five American soldiers enter Nazi-occupied Europe on a covert assignment to kidnap the head of Operation Bernhard. Keywords for Free Movies Tell Me How I Die (2016): M4uFree 123 Movies, Free Movie, Best Movies, Watch Movie Online , Watch Tell Me How I Die (2016) movie online, Free movie Tell Me How I Die (2016) with English Subtitles, Watch Tell Me How I Die (2016) full movie, Watch Tell Me How I Die (2016) in HD quality online for free, Tell Me How I Die (2016) , download Tell Me How I Die (2016), watch Tell Me How I Die (2016) with HD streaming	cc/2021-04/en_middle_0036.json.gz/line883
__label__cc	0.732158	0.267842	Towsley Fire In Newhall 10% Contained, 50-60 Acres BurnedHours after a fire broke out Tuesday west of the 5 Freeway in Newhall, the Los Angeles County Fire Department said there were no structures threatened and containment had grown to 10%. Rape Allegation Prompts Campus-Wide Alert At LMU Filed Under:Alleged Rape, LMU, Loyola Marymount University, Westchester WESTCHESTER (CBSLA.com) — Students at Loyola Marymount University were warned this week about a rape at an off-campus party. It allegedly took place in the early morning hours of Nov. 1 in the 8700 block of Yorktown Avenue, according to an email alert sent by school officials Wednesday to the university community. The house in question, approximately three miles from campus, is home to an unofficial fraternity, Sigma Alpha Epsilon. Several neighbors said they saw police and college students surround the house during a party on Halloween night. The campus alert included safety tips for students that suggested students remain alert, not walk alone at night, report suspicious activity to police, scan parking lots and streets, look “confident and purposeful” while walking and “not flash” things such as cell phones and laptops. The fraternity issued a statement Monday regarding an investigation by the organization’s national headquaters. “We are committed to the safety and well-being of our members and the guests with whom they interact, and that commitment includes making sure our members provide a safe, enjoyable environment in their homes. Any form of assault or sexual misconduct is unacceptable, and we will not tolerate actions that are inconsistent with our values. In addition, Sigma Alpha Epsilon will not hesitate to take corrective actions or impose sanctions on any member or chapter that fails to follow the stringent guidelines we set forth in our comprehensive health-and-safety program,” Associate Executive Director of Communications Brandon E. Weghorst said. Anyone with information about the allegation was asked to call the LAPD’s Pacific Division at (310) 482-6334.	cc/2021-04/en_middle_0036.json.gz/line887
__label__cc	0.541999	0.458001	Patreon donations ← 2020 Year in Review Looking forward: new technologies in the 2020’s → The relative infectivity of the new UK variant of SARS-CoV-2 Posted on December 29, 2020 by niclewis \| 229 Comments By Nic Lewis A new variant, B.1.1.7, of the SARS-CoV-2 virus has recently spread rapidly in England The public health agency’s best estimate of B.1.1.7’s weekly growth rate advantage is 1.51x They mis-convert this in a reproduction number ratio of 1.47; converting appropriately gives a ratio of 1.25 Confident claims by the UK government scientific advisers that the higher growth of B.1.1.7 is due to increased transmissibility are misplaced; it could be partly of wholly due to other factors 1.1.7 has not shown a greater growth rate advantage than two previous variants did, both of which are now thought to have no greater transmissibility than previously existing variants There is little evidence that B.1.1.7 is more virulent, or likely to be resistant to existing vaccines The apparent rapid growth in England of a new variant of the SARS-CoV-2 virus that causes COVID-19 has led to dire warnings by those advising the UK government. Their advice suggested only that the new variant was more transmissible (more infective), not that it was more virulent (causes more serious illness). Nevertheless, it resulted in swift (many would say panicky) actions first by the UK government and then by governments of many other countries. The UK government imposed further restrictions on people’s freedom to mix and to move, while other countries banned travellers from the UK. Many millions of people in the UK had to cancel their plans for the Christmas holiday at very short notice, in addition to having their freedoms further curtailed thereafter. In this article I examine to what extent the advice that led to these damaging government actions was justified. The new strain, B.1.1.7, and its spread in the UK The UK government agency Public Health England (PHE) termed the new variant VUI-202012/01, and now VUC-202012/01, but I shall refer to it by the scientific name given to its lineage, B.1.1.7 (Rambaut et al.)[1], or just as “the new variant”. The lineage involves 8 amino acid changes (6 mutations and 2 deletions)[2] in the gene for the important spike protein, along with 9 amino acid changes[3] in genes for other proteins. The lineage has sometimes been referred to just by the name of the best known mutation it possesses, N501Y, but doing so is to be avoided as there are other variants that also have this mutation. Rambaut et al. have this to say about the new lineage: The B.1.1.7 lineage carries a larger than usual number of virus genetic changes. The accrual of 14 lineage-specific amino acid replacements prior to its detection is, to date, unprecedented in the global virus genomic data for the COVID-19 pandemic. They also identify three of the mutations in particular (including N501Y) as being suspected of having potential biological effects. B.1.1.7 was first detected in SARS-CoV-2 sequenced from a sample collected in south-east England on 20 September 2020, since when the cluster of cases has grown rapidly and spread to other locations. The UK sequences many more SARS-CoV-2 genomes than any other nation, and more than the rest of Europe combined, so the fact that B.1.17 was first detected in the UK does not necessarily imply that it originated there. The lineage has also been detected in several other countries and may well now be widespread. Growth of the B.1.1.7 lineage in the UK can be tracked in sequencing data uploaded to GISAID. I used the COVID-CG processing facility[4] to select each day’s sequences with all eight B1.1.7 spike gene mutations.[5] As the daily data were noisy and few sequences were dated after 12 December 2020, I took 7-day moving averages, centred up to 9 December. Figure 1 shows the resulting proportion of all UK sequences represented by the B.1.1.7 lineage since its first emergence. It should be noted that the proportion of non-B.1.1.7 sequences represented by the areas in which B.1.1.7 first grew to prominence may have increased over time, resulting in the growth shown overstating how fast it grew in individual areas or in the UK as a whole. Figure 1. The proportion of all SARS-CoV-2 genomes sequenced in the UK made up by the B.1.1.7 lineage The higher growth rate of B.1.1.7 A PHE report published on 21 December 2020[6] presents epidemiological evidence about the growth rate of B.1.1.7 relative to non-B.1.1.7 lineages. By using a proxy marker for B.1.1.7[7] they were able to utilise data from a significant proportion of the UK ‘pillar 2’ testing programme. Doing so provided a much larger dataset than that of sequenced SARS-CoV-2 genomes, and enabled stratification of weekly data for each of 42 NHS “STP” areas. Figure 2 reproduces Figure 1 of the PHE document, which shows the multiplicative advantage in weekly growth rates of B.1.1.7 cases (the ratio of B.1.1.7 to non-B.1.1.7 week t+1 cases divided by week t cases). The x-axis is for the B.1.1.7 proxy, S gene test negative. The week stated is the base week, so the yellow points reflect ratios of week 49 (week ending 5 December) cases to week 48 cases. Figure 2. Empirical data analysis of the multiplicative advantage in weekly growth rates. Each point represents the ratio of weekly growth rates between B.1.17 [VOC] and non-B.1.1.7 for an NHS England STP area and week, based on the pillar 2 data shown in Figure S1 of the PHE report. Colours and shapes differentiate calendar weeks. Numbers above 1 show a multiplicative advantage. The blue line represents the mean value for a particular frequency, and the grey lines the 95% envelope. Scatter at low frequencies largely reflects statistical noise due to low counts. When the new variant represents a small proportion of total cases (under ~ 25%, say), the proxy used is less satisfactory, and there is also a lot of scatter. Nevertheless, the variant’s proxy-based mean multiplicative advantage (ratio) in weekly growth is remarkably independent of its relative prevalence. That supports PHE’s methodology, although the week 48 data suggests that the multiplicative advantage might decline once the variant makes up more than ~25% of the total cases. PHE compute from this data a mean multiplicative advantage in weekly growth of 1.51 for B.1.1.7. By assuming a fixed generation interval of 6.5 days, they convert this into a reproduction number (Rt) multiplicative advantage of 1.47 for B.1.1.7 relative to other variants,. PHE also estimated the effect of B.1.1.7 on Rt using genomic (sequencing) data for the same areas and weeks. They estimated an additive effect on Rt of 0.57, or 0.74 when the effect was allowed to vary between areas. PHE also estimated the effect on Rt using the PCR test S gene proxy data, adjusted for specificity (which is poor when the S gene negative proportion is low). Their estimates of the additive effect on Rt using that data were 0.52, or 0.60 when the effect was allowed to vary between areas. Using a Bayesian regression model their estimate of the effect was 0.56. However, since any biological difference in infectivity would be expected to cause a multiplicative effect on Rt, and Rt was varying during the analysis period, an estimated additive effect on Rt is less useful and also liable to be less accurate than a multiplicative estimate. In addition all these estimates involve more complicated statistical models, further assumptions and estimates of other variables. I therefore prefer their estimated multiplicative advantage of 1.51 (for weekly growth, prior to conversion to Rt scale), which is directly derived from underlying data. This is equivalent to a logarithmic daily growth rate advantage of 0.059. Other evidence regarding the faster growth of B.1.1.7 A meeting of the NERVTAG[8] committee – which advises the government on the threat posed by new and emerging respiratory viruses – on the new variant took place on the 18 December 2020. The minutes[9] refer to an estimate from genomic data of a growth rate 71% higher than other variants; none of the documents that was considered by the committee contained such an estimate. It appears from the minutes of a subsequent meeting on 21 December 2020[10] that this was one of several undocumented estimates from NERVTAG member Professor Neil Ferguson of Imperial College. An alternative regression estimate that he apparently presented indicated that lineage B.1.1.7 had a Rt 0.39 higher than non-variant lineages from early November to early December. This is presumably an additive effect estimate, and is noticeably lower than PHE’s estimates using much the same method. Two other estimates stated in the minutes to be from Professor Ferguson both appear to actually be slightly misstated versions of the PHE estimate of a multiplicative Rt advantage of 1.47 for B.1.1.7. The minutes of a further NERVTAG meeting the 21 December also mention a London School of Hygiene and Tropical Medicine estimate that B.1.1.7 was 56% more transmissible (a multiplicative advantage of 1.56 in Rt value). This estimate is documented in a preprint (Davies et al.[11]). The authors use a Subjective Bayesian method to fit a highly complex model with many probabilistic parameters, some fixed and others estimated. This is a far from robust, and quite possibly inherently biased, method of estimating the relative transmission rate. Moreover, they appear to use less informative data, broken down geographically only by the 7 NHS regions, not (as PHE used) by the 42 NHS STP areas. The use of less informative data implies that, even if they had employed a robust method, their estimates would be expected to be inherently less reliable than the PHE estimate. The uncertainty ranges of their estimates – which include a 99%+ confidence interval of 1.49x to 1.57x for the South East[12] region – appear to be quite unrealistically narrow, given the substantial uncertainties that exist. That casts further doubt on the realism of their estimates. Finally, the NERVTAG 21 December meeting also considered a University of Edinburgh (Andrew Rambaut) phylogenetic estimate based on genetic sequences from Kent and London, that Rt was 1.57 or 1.72 depending on the time window used. Since no comparative Rt estimate for non-B.1.1.7 variants is mentioned in the meeting minutes, it is not possible to infer from this an estimate of the relative transmission rate of the new variant. I conclude that the other evidence considered by NERVTAG is less robust and less useful than the PHE estimate of a multiplicative advantage in weekly growth of 1.51. Why the faster growth of B.1.1.7 need not be due to increased transmissibility While the evidence that the B.1.1.7 lineage has grown faster than other lineages in England over the two months or so to early/mid-December seems robust, one cannot infer biological properties of a virus from limited epidemiological data only. The apparent rapid spread of this new variant might be due to founder effects and super-spreader events rather than, or in addition to, increased transmissibility (higher infectivity). It is instructive in this regard to consider two other lineages/variants that also had a period of exceptionally fast growth and, in one case, came to be totally dominant in most countries. The G clade: spike gene mutation D614G The D614G mutation arose early in the epidemic, emerging in Europe in February, and the G614 variant undoubtedly spread faster in most locations than D614. In very many countries, areas and cities it went from representing a minority of infections to being the dominant variant within a period of month or so. Since July 2020 it has accounted for approaching 100% of new infections in most countries and in all continents. In the light of D614G becoming and remaining so dominant, it is unsurprising that a paper in August (Korber et al.[13]) argued that the D614G mutation increases transmissibility, citing several pieces of evidence: the consistency of increase [in frequency of G614] across geographic regions. the D614 form did not persist in many locations where the G614 form was introduced into the ongoing well-established D614 epidemics, as would be expected if the two forms were equally likely to propagate. the increase in G614 frequency often continued well after national stay-at-home orders [lockdowns] were in place, when serial reseeding from travellers was likely to be reduced significantly. In addition to that epidemiological evidence, the authors also noted that increased transmissibility of G614 was consistent with other studies that suggested associations with increased infectivity in vitro[14] [15], and with their own finding of an association with higher viral loads in vivo. Moreover, another paper (Li, Q et al[16]) reported higher antigenicity for G614. Most of Korber’s arguments are also fairly applicable to evidence suggesting that B.1.1.7 may be more transmissible. However, a more recent paper in Nature (van Dorp et al.[17]) found “no evidence for significantly more transmissible lineages of SARS-CoV-2 due to recurrent mutations”, including D614G (B.1.1.7 had not been identified by the end of the study period). This shows that, even after a new strain has become dominant, conclusions about its relative transmissibility drawn from epidemiological and indirect biological evidence may turn out to be wrong. The 20A.EU1variant: spike mutation A222V The 20A.EU1 variant, which involves spike gene mutation A222V, emerged in Spain in early summer 2020. It rapidly spread to other European countries, where it typically grew faster than non-20A.EU1 variants. Figure 3 plots the logarithmic daily growth rate of sequences with the A222V mutation in the UK, relative to those without it, over the two months to mid-September. Over that period the ratio of A222V to non-A222V new sequences grew from under 0.02 to 0.67. The mean logarithmic daily growth rate was 0.061 – a weekly multiplicative advantage of 1.53 – with essentially no trend. That multiplicative advantage is effectively identical to the 1.51 estimate by PHE for B.1.1.7 using data from mid-October to mid-December. Figure 3. The logarithmic daily growth rate of the 7-day moving average of new sequences with the A222V mutation in the UK, relative to those without it, over the two months to 12 September 2020. However, in the autumn the relative frequency of new A222V sequences stopped increasing in a number of countries, without – as D614G did – achieving total and continuous dominance (Figure 4). In the UK the A20.EU1 variant reached some 70% of all new sequences by the end of October, but it has since declined in relative frequency, as it has also done in Belgium, Germany and Switzerland. Figure 4. The proportion during 2020 of weekly new SARS-CoV-2 sequences in ten European countries that have the A222V mutation (implying they are the A20.EU1 variant) Notwithstanding the rapid growth of the 20A.EU1 variant in many European countries during the summer and/or autumn, a November 2020 preprint paper about 20A.EU1 concluded: “We find no evidence of increased transmissibility of this variant, but instead demonstrate how rising incidence in Spain, resumption of travel across Europe, and lack of effective screening and containment may explain the variant’s success”.[18] Overestimation of effect on Rt of possible increased transmissibility Supposing that the higher growth rate to date of the B.1.1.7 lineage were all due to higher transmissibility, what effect would this have on the current reproduction number, Rt? That will depend on what Rt is and on the mean generation interval and its probability distribution. The longer the generation interval, the higher Rt required to produce a given growth rate. In the 21 December PHE publication, their estimate of the multiplicative advantage in weekly growth rate (of 1.51) is converted to a multiplicative advantage in Rt of 1.47 by assuming a fixed generation interval of 6.5 days: 1.47 = 1.51^(6.5/7). However, PHE’s conversion formula is not justified, for two reasons: the generation interval is not fixed; and recent estimates of the mean generation interval are well below 6.5 days. Most estimates of the generation interval (the period from one person being infected to them infecting another person) are in fact estimates of the serial interval (the period from the symptom onset in one person to symptom onset in a person they infect), since the time of infection is not observable. The generation interval can be validly estimated by combining probabilistic estimates of the serial interval and the incubation period (from infection to symptom onset). However, simply treating a probabilistic serial interval estimate as representing the generation interval distribution, as is typically done, is unsatisfactory. PHE give no source for their assumption of a 6.5 days generation interval, but they could be following the Imperial College team, who used (in Flaxman et al.[19]) a generation interval with a 6.5 days mean, stating it was estimated by Bi et al.[20]. In fact, Bi et al. estimated the serial interval, not the generation interval, and fitted a gamma probability distribution with a mean of 6.3 days. However, their data included cases where the infecting individual did not isolate from others until long after symptom onset. Bi et al. found that if the infected individual was isolated less than three days after symptom onset, which would normally be the case in the UK now, the average serial interval was only 3.6 days. Knight and Mishra (2020)[21] show that, to avoid overestimating the serial interval, it needs to be fitted to a probability distribution that, unlike the gamma distribution used by Bi et al., permits negative values (which are observed in a non-negligible proportion of cases). They consider a number of estimates examined in a review article of the incubation period and the serial interval, selecting the only serial interval estimate based on a negative-permitting probability distribution that had a large sample size (nearly ten times as large as that in Bi et al.), and the incubation period estimate that was based on the largest sample. Their resulting generation interval estimate has a mean of 3.99 days and a standard deviation of 2.96 days.[22] Davies et al. say that their complex Bayesian model, which estimated a multiplicative advantage of 1.56 in Rt value using a fairly long generation interval, fitted less well when they used a shorter interval. However, it seems probable that the main reason they obtain a poor fit to the relative growth in the new variant during lockdown with a shorter generation interval is that their model greatly overestimates the effect of the November lockdown. [23] Using the Knight and Mishra estimated distribution for the generation interval, and the correct conversion formula,[24] the PHE estimate of the B.1.1.7 lineage’s multiplicative advantage in weekly growth rate of 1.51 corresponds to a multiplicative advantage in Rt of 1.25.[25] That is only about half the multiplicative advantage of 1.47 estimated by PHE.[26] It implies that less extensive and severe measures would be required to prevent exponential growth of infections given the emergence of B.1.1.7 than is implied by the PHE estimate of a 1.47 multiplicative advantage in Rt, even if the observed multiplicative advantage in weekly growth rate of B.1.1.7 to mid-December is entirely caused by it being more transmissible. The new South African variant A new SARS-CoV-2 lineage that also involves a N501Y spike gene mutation, and a number of other mutations (differing from those in B.1.1.7), has recently emerged in South Africa, as described by Tegally et al.[27], who term it 501Y.V2. They say that genomic data, showing the rapid displacement of other lineages, suggest that this lineage may be associated with increased transmissibility. However, the limited evidence available so far is insufficient to justify the alarmist comments from the UK government health minister, that “This new variant is highly concerning because it is yet more transmissible and it appears to have mutated further than the new variant discovered in the UK”.[28] As a professor of molecular virology at the University of Nottingham stated, the mutation involved has been seen before, we have no idea whether it impacts on virus transmissibility, and we should avoid panicking at this point.[29] The G clade and 20A.EU1 examples illustrate that apparently strong epidemiological evidence of a higher growth rate of a new variant over considerable period, even where it leads to apparently permanent dominance, and notwithstanding it being accompanied by evidence suggesting that the variant is associated with higher viral loads, does not enable a valid conclusion that the variant has higher transmissibility than existing variants. Such evidence may be suggestive of higher transmissibility, but it does not reliably demonstrate it. Despite this, the NERVTAG committee concluded with moderate confidence on 18 December that the new variant “demonstrates a substantial increase in transmissibility compared to other variants” and at their 21 December meeting went further and expressed high confidence that “B.1.1.7 can spread faster than other SARS-CoV-2 virus variants currently circulating in the UK”. While admitting that the underlying cause of faster spread was unclear, the causative factors that they suggested related exclusively to higher transmissibility. It is not surprising, given that NERVTAG’s confident conclusions are not justified by the facts, that a number of experts in the UK and other countries have disputed them[30] or expressed contrary views,[31] [32] [33] Unsurprisingly, the mainstream media are reporting, incorrectly, that B.1.1.7 has been proven to possess substantially increased transmissibility. I have argued that the estimate by PHE of a multiplicative weekly growth advantage of 1.51 for B.1.1.7 is, for several reasons, more robust and accurate than the other available estimates. I have shown that, even if the higher growth to date of B.1.1.7 were due entirely to increased transmissibility, it would correspond to a multiplicative advantage in Rt of only 1.25, half as high an advantage as calculated by PHE using an inappropriate conversion formula. There is no evidence to date that B.1.1.7 is any more any virulent than existing strains, nor that it will be resistant to the vaccines that have been developed. Expert opinion appears to be that neither of these are likely to be the case.[34] These findings imply that B.1.1.7 does not currently appear to represent a serious increase in the menace posed by SARS-CoV-2, even in the worst case that its higher observed growth rate is entirely due to increased transmissibility. In the best case, its higher growth rate will turn out not to spring to any extent from increased transmissibility, as now appears to be the case with the G clade and 20A.EU1 variant. Accordingly, it is difficult to see that imposing drastic measures to slow transmission, further reducing economic activity, social activity and peoples freedom, are justified by the current evidence regarding the emerging B.1.1.7 lineage. However, as further evidence becomes available it could strengthen, or weaken, the case that the emergence of B.1.1.7 represents a serious development. It is important that the UK authorities start to release, on a daily basis and at local authority area or finer level, all available data on cases of the new strain, as indicated by the ‘S gene negative’ proxy and any other method. At present they are keeping this information non-public, which makes it impossible for independent researchers properly to assess on a timely basis, and if necessary challenge, what may be mistaken conclusions. Moreover, it is highly desirable that no SARS-CoV-2 or COVID-19 related report or study should hereafter be considered by the government or its advisers unless it is accompanied by a link at which all the data used is available. Nicholas Lewis 29 December 2020 [1] Rambaut, A et al: Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. COVID-19 Genomics Consortium UK, ARTIC network 19 December 2020. https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 [2] N501Y, A570D, P681H, T716I, S982A and D1118H mutations plus HV69-70 and Y144 deletions [3] T1001I, A1708D and I2230T mutations plus SGF3675-3677 deletion in the ORF1ab gene; R52I and Y73C mutations plus Q27stop codon in the Orf8 gene; D3L and S235F in the N gene. There are also 6 synonymous (non-amino acid changing) mutations: 5 in ORF1ab (C913T, C5986T, C14676T, C15279T, C16176T), and 1 in the M gene (T26801C). [4] https://www.covidcg.org/?tab=location# . Data downloaded 26 December 2020. [5] Only the total number of each day’s sequences with each mutation are available via COVID-CG, but the number of each of the eight spike mutations appearing each day (r >0.999, except 0.991for the HV69-70 deletion, which sometimes occurs in other strains), implying that they have an extremely high co-occurrence. I took the minimum number each day for the eight spike mutations as the count for B.1.1.7 sequences. Incorporating non-spike mutation data appears unnecessary; the match of all B.1.1.7 spike mutations with all ORF1ab B.1.1.7 mutations is almost perfect apart from A1708D, which seems absent in about 1% of cases where all 11 other spike and ORF1ab mutations are present. [6] Public Health England: Investigation of novel SARS-COV-2 variant – Variant of Concern 202012/01. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/947048/Technical_Briefing_VOC_SH_NJL2_SH2.pdf [7] S gene negative, N and ORF1ab positive TaqPath PCR test result. [8] NERVTAG: New and Emerging Respiratory Virus Threats Advisory Group [9] NERVTAG COVID-19 VUI communication 18122020_final.pdf, available at https://app.box.com/s/3lkcbxepqixkg4mv640dpvvg978ixjtf/folder/111416414559 [10] NERVTAG COVID-19 VOC communication 21122020 final.pdf, available at https://app.box.com/s/3lkcbxepqixkg4mv640dpvvg978ixjtf/folder/111416414559 [11] Davies, NG et al: Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England. Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, updated 23 December 2020. https://cmmid.github.io/topics/covid19/reports/uk-novel-variant/2020_12_23_Transmissibility_and_severity_of_VOC_202012_01_in_England.pdf [12] Figure1A of Davies et al, rightmost panel. [13] Korber, B. et al. Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell 182, 812.e19–827.e19 (2020). https://doi.org/10.1016/j.cell.2020.06.043, 20 August 2020 [14] Zhang, L. et al. The D614G mutation in the SARS-CoV-2 spike protein educes S1 shedding and increases infectivity. Preprint at https://doi.org/10.1101/2020.06.12.148726, 12 June 2020 [15] Yurkovetskiy, L. et al. Structural and functional analysis of the D614G SARSCoV-2 spike protein variant. Cell 183, 739.e8–751.e8 https://doi.org/10.1016/j.cell.2020.09.032, October 2020 [16] Li, Q. et al. The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity. Cell 182, 1284.e9–1294.e https://doi.org/10.1016/j.cell.2020.07.012, September 2020 [17] van Dorp, L et al., No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2. Nature, November 2020. https://doi.org/10.1038/s41467-020-19818-2 [18]Hodcroft, BH et al: Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020. medRxiv 27 November 2020 https://doi.org/10.1101/2020.10.25.20219063 [19] Flaxman, S., Mishra, S., Gandy, A. et al. Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe. Nature 584, 257–261 (2020). https://doi.org/10.1038/s41586-020-2405-7 [20] Bi, Q. et al. Epidemiology and Transmission of COVID-19 in Shenzhen China: Analysis of 391 cases and 1,286 of their close contacts. medRxiv (2020) https://doi.org/10.1101/2020.03.03.20028423 [21] Knight, J. and Mishra, S.: Estimating effective reproduction number using generation time versus serial interval, with application to COVID-19 in the Greater Toronto Area, Canada. Infectious Disease Modelling 5 (2020) 889e896, November 2020. https://doi.org/10.1016/j.idm.2020.10.009 [22] Knight and Mishra fit their generation interval estimate using a gamma distribution. Unlike the serial interval, the generation interval cannot be negative so a gamma distribution is suitable here. [23] They say that the poor fitting with a shorter generation interval was because it predicted that the new strain should have decreased in relative frequency during November’s lockdown. As they write: “When Rt < 1 for both variants, a shorter generation time is a selective disadvantage, because infections with this variant decline faster compared to a variant with the same Rt but transmitting on a longer timescale.” However, that is only true if Rt was below 1 during lockdown, whereas their Fig. 1E shows that, in reality, Rt remained at or marginally above 1 during lockdown. That is consistent with the mobility data in Davies et al. Fig.1C, which show little difference between immediately prior to the start and the end of lockdown. An overall Rt of 1 implies that the infections with the more transmissible variant will increase in relative frequency, as occurred, not decrease. Also, the complexity of their model means that the poor fitting could to be partially or wholly due to other causes, such as a long generation interval compensating for another parameter being misestimated, or to the peculiar way in which they represented a shortened generation interval. [24] Wallinga, J., & Lipsitch, M. (2007). How generation intervals shape the relationship between growth rates and reproductive numbers. Proceedings of the Royal Society B: Biological Sciences, 274(1609), 599-604. https://doi.org/10.1098/rspb.2006.3754 Using their equation 2.9 in conjunction with the gamma distribution moment generating function. [25] The estimate of the multiplicative advantage assumes that Rt for the other strains is 1.0; the inferred multiplicative advantage is a slowly decreasing function of Rt for the other strains. [26] The same is approximately true throughout PHE’s 95% confidence interval of for the Rt ratio of 1.34–1.59, which when converted in the same way corresponds to an Rt ratio range of 1.19–1.30. [27] Tegally, Houriiyah, et al. “Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa.” medRxiv 22 December 2020. https://doi.org/10.1101/2020.12.21.20248640 [28] As quoted in the Guardian, 23 December 2020. https://www.theguardian.com/world/2020/dec/23/south-african-covid-19-variant-has-reached-the-uk-says-matt-hancock [29] Professor John Ball, as quoted at https://www.sciencemediacentre.org/expert-reaction-to-south-african-variant-of-sars-cov-2-as-mentioned-by-matt-hancock-at-the-downing-street-press-briefing/ [30] Vincent Racaniello, Professor of Immunology, Columbia University. Extensive detailed comments, including that “none of the isolates so far have proven implications for human transmission or pathogenesis, including the latest variant isolated from the UK.” and, concerning the NERVTAG 21 December meeting: “You can’t use epidemiological data to prove a biological effect of a amino acid change in a virus; you have to do experiments to do that. And that’s what they’re doing here. They say, there is an increase in the transmissibility. It must be because of the variant. Well, obviously that’s a flawed argument. That’s not how we do science.” https://www.virology.ws/2020/12/24/sars-cov-2-uk-variant-does-it-matter/ ; transcript at https://dryburgh.com/vincent-racaniello-coronavirus-variant-voc-202012-01/ [31] Dr Julian Tang, Honorary Associate Professor/Clinical Virologist, University of Leicester, said: “The spread of this new virus variant could be due to many factors. As we saw with the earlier D614G variant – just higher viral loads in clinical diagnostic swabs or in cell culture may not necessarily translate to a more transmissible virus at the population level. “A higher genomic growth rate in the samples sequenced, may not necessarily mean higher transmissibility, e.g. if there was a rave of several thousand people where this variant was introduced and infected many people mostly in that rave, this may seem very high compared to a lower background of non-variant virus, e.g. in an otherwise prevailing national lockdown.” https://www.sciencemediacentre.org/expert-reaction-to-brief-summary-of-nervtag-opinion-from-the-nervtag-meeting-on-sars-cov-2-variant-under-investigation-vui-202012-01/ [32] Professor Vineet Menachery, University of Texas Medical Branch, said: “So this isn’t the first time we’ve seen variants emerge quickly or begin to dominate the population of viruses that we’re seeing. And so I’m not particularly worried at this moment. There is evidence that it is maybe slightly more transmissible, but we’re not at this point knowing enough about it to really be scared in the sense that it’s a different order of magnitude, that it’s going to be a major threat moving forward.” https://health.wusf.usf.edu/npr-health/2020-12-21/new-coronavirus-variant-found-in-u-k-what-does-it-mean-for-the-world [33] Dr Nusrat Homaira, Respiratory Epidemiologist, UNSW Sydney. “There is modest evidence suggesting that this new variant of Sars-CoV-2 is more transmissible, and is speculated to be the reason for the recent increase in the number of Covid-19 cases in London, South East, and East of England regions.” https://www.dhakatribune.com/opinion/op-ed/2020/12/24/the-new-variant-of-the-sars-cov-2-what-it-all-means [34] Dr Julian Tang, Honorary Associate Professor/Clinical Virologist, University of Leicester, said: “We are not seeing any increased virulence (clinical severity) or any gross changes in the S (spike protein) that will reduce vaccine effectiveness – so far.” https://www.sciencemediacentre.org/expert-reaction-to-brief-summary-of-nervtag-opinion-from-the-nervtag-meeting-on-sars-cov-2-variant-under-investigation-vui-202012-01/ Originally posted here, where a pdf copy is also available 229 responses to “The relative infectivity of the new UK variant of SARS-CoV-2” J Anderton \| December 29, 2020 at 7:14 am \| Reply The genome change and continued vaccine efficacy gives me a question for someone more knowledgeable: What prevents the mRNA vaccine from triggering immune response against valuable hormones; since some hormones also use “spike” (Glyco)proteins? James Cross \| December 29, 2020 at 9:16 am \| Reply That’s an interesting question that I really don’t know the answer to. However, I think it is why mRNA vaccines have take decades to come to market. I think there is some magic in the delivery mechanisms and some of it may be proprietary. Here is quote from a Moderna SEC filing: “We pursue mRNA science both to minimize undesirable activation of the immune system by mRNA and to maximize the mRNA potency of mRNA once inside target cells. We pursue delivery science to protect mRNA from extracellular enzymes that would degrade it, to avoid counterproductive interactions of our delivery vehicles with the immune system, deliver mRNA to desired tissues, and facilitate mRNA transport across cell membranes to the translational machinery within cells”. https://www.sec.gov/Archives/edgar/data/1682852/000168285220000006/moderna10-k12312019.htm James Cross \| December 29, 2020 at 9:18 am \| To add to that, I think it has something to do with encapsulating the mRNA in a lipid. More detail. “Moderna, for its part, decided years ago that lipid nanoparticles (LNPs) looked like the way to go. This technique places the RNA constructs inside small lipid bubbles of lipid to protect them, and there’s an ever-growing list of variations on the idea and how to realize such species in practice”. https://blogs.sciencemag.org/pipeline/archives/2020/07/24/formulating-rna-and-owning-it rovingbroker \| December 29, 2020 at 5:43 pm \| Reply “What prevents the mRNA vaccine from triggering immune response against valuable hormones … ” The vaccine does not trigger an immune response against any hormone. The vaccine prepares the patient’s immune system to make an immune response to a protein (specifically a “spike” protein) that exists only on the surface of a Covid-19 virus when it shows up in the body. That immune response kills the Covid-19 virus. The immune response does not harm any other cells. https://www.cdc.gov/vaccines/covid-19/hcp/mrna-vaccine-basics.html Franktoo \| December 31, 2020 at 4:37 am \| Reply The mRNA vaccine is surrounded with a layer of lipid that fuses with human cell membranes and allows the mRNA enter human cells. Lipids have been used in cell culture experiments for more than 30 years to allow cells to take up foreign DNA or RNA (“transfection). The mRNA is accepted by ribosomes, the machinery inside cells that “translates” mRNA into proteins. Some existing gene therapy protocols and some DNA vaccines use lipids to help DNA enter cells, but most incorporate the therapeutic DNA into a relatively harmless virus that already knows how to enter human cells more efficiently. The mRNA causes some human cells it enters to produce a subunit of the SARS-CoV-2 spike protein. Your immune system creates antibodies that bind with high affinity and selectivity to the spike protein subunit – and if we are lucky also to the spike protein in whatever strain of SARS-CoV-2 we may encounter for the next few years. Since we understand exactly which amino acid residues on the spike protein are essential for binding to the ACE2 receptor and essential for infecting human cells, and since we know the antibodies we create bind those same amino acids, there is good reason to expect that mutant viral strains that aren’t recognized by the antibodies also won’t be able to infect humans cells very efficiently. Antibodies are highly selective in what they bind to: they won’t bind to your proteins or hormones and probably not to the spike protein from the coronaviruses that cause the common cold or SARS-CoV-1. Antibodies are a highly selective means of distinguishing between foreign and host proteins. Autoimmune diseases are the result of antibodies recognizing proteins made by you, so evolutions has engineered antibodies to be highly selective to avoid this problem. None of the 20,000 vaccinated in clinical trials developed an auto-immune disorder. A few people with severe allergies have experienced immediate reaction to vaccination similar to the immediate allergic reaction to a bee sting. Since mRNAs are degraded within a few days, no trace of the mRNA remains in your body. Likewise, the protein made from the mRNA is also degraded after being recognized as foreign by your immune system. Other vaccines consist of weakened viruses (which replicate in your body), dead viruses (which often don’t induce a strong immune response) or DNA encoding for viral proteins (which can be incorporated into your DNA). Pingback: The relative infectivity of the new UK variant of SARS-CoV-2 – Climate- Science.press archibaldtuttle \| December 29, 2020 at 9:36 am \| Reply The money quote is the conclusion of the conclusion: “It is important that the UK authorities start to release, on a daily basis and at local authority area or finer level, all available data on cases of the new strain . . . At present they are keeping this information non-public,” Information is power. This seems a reasoned critique in the Hitchhikers Guide to the Galaxy meme of “Don’t Panic”, while not discounting plausible indications of increased transmissibility. As usual, the equally plausible concern continues to be for availability of raw data such that the science can be critiqued and/or replicated, an apparently bothersome requirement whether in climate or covid is involved, i.e. anything that is a big public policy driver. Ron Graf \| December 29, 2020 at 9:46 am \| Reply Nic, thanks, your research is superb but I’m wondering if you could provide an example demonstrating how a variant could dominate without being more contagious. I would like to visualize how founders effect would work in the midst of epidemic to amplify one variant to become dominant. My current thinking is that equally contagious mutations would simply lead to variety in the virus population. And how did the February European strain become dominate without being more contagious than the original? Ron Graf \| December 29, 2020 at 10:11 am \| Reply Besides the importance of policy makers understanding of this it also goes to the virus’s natural origin theories. If very slight advantages have such profound effects on propagation it makes it implausible that a virus would could skip to another animal, adapt to that host, and then return to its first host species to outcompete its original strain. But this route is what is being postulated by this recent paper to explain why CoV2 is 96% genetically similar to a bat virus collected in Yunan province of China in 2013, and only 91% similar (overall) to pangolin-CoV, which has a similar spike to CoV2. From the paper: “Our analyses provide further support that SARS-CoV-2 originated from bats, considering that bat isolates may be the major parent contributing the largest fraction of sequences [explaining the 96% similarity to Cov2] ….Bat coronaviruses may have more chances to take part in recombination than coronaviruses from other hosts and thus play the most important role in the origin and recombination of human coronaviruses among all known coronavirus hosts [explaining their assertion of the uptake of the pangolin spike protein].” https://www.nature.com/articles/s41598-020-78703-6 Franktoo \| December 31, 2020 at 9:36 pm \| Ron wrote: “Evolutionary forces thus drive the virus to be less and less incapacitating but more and more infectious to the host species. This is why most viruses can’t jump and propagate in the non-host species, but if they do they are usually more harmful. That NIH scientists felt that making lab chimera bat-human viruses was too dangerous to do in the USA but fine to fund Chinese research was nuts. Since SARS-CoV-2 is not very incapacitating and highly transmissible, I don’t think much evolutionary advantage will drive evolution of a less incapacitating strain. The fact that something like 50% of people are asymptomatic is a clear sign of this. Questions were raised about the risks and benefits of laboratory experiments (“gain of function” experiments) that attempt to simulate in the laboratory the evolutionary process of adapting a wild viral strain (say from bats) to efficiently replicate in a human cell line or a lab mammal. The goal was to safely create and study the kind of threats we anticipated encountering in the future – in the safety of a specially-designed laboratory. Such experiments were being done in one or two dozen laboratories around the world, including Wuhan’s. when serious questions arose, the NIH stopped such experiments (including those in Wuhan) while the risks were assessed. The assessed risk was cumulative: several dozens labs carrying out such experiments over several decades given the escape rate and accident rate experienced by such labs in the past. Based on that analysis, the experiments were allowed to resume. On that basis, the chance of an accidental escape occurred in Wuhan in October or November of 2019 must have been minuscule. Since every other viral pandemic in history has begun with natural adaptation of a virus to humans (or more likely first to [domesticated] animals that live near humans), we don’t need to postulate that something novel – human experiments – must have created the SARS-CoV-2. The mystery about SARS-CoV-2 is why COVID was first identified in Wuhan, which is far from the logical place of origin – bat-infested Southern China. This was the location that another deadly coronavirus from bats emerged less than two decades earlier. That virus was too incapacitating and deadly to escape Southern China without being detected and identified. My hypothesis is that we think of Wuhan as the source of COVID, when it was merely the location of the first super-spreader event(s) in a major city (with the medical sophistication to the identify the disease). IMO, COVID likely originated in rural Southern China and was carried undetected to Wuhan in a person or a short chain of people or via infamous wild animals the Chinese like to consume. Wuhan is a city bigger NYC with the largest wild animal market in Central China a perfectly logical place for COVID to emerge from either source. Yes, we know there were COVID cases in early December that were not directly linked to that market, but the ancestor to the initial three strains sequenced existed in November or possibly late October. And that ancestor virus could have existed in the live animal market or a person who worked there. (The Chinese government destroyed all samples, so we will never know if their neglect of the wild animal trade allowed a pandemic virus to reach a major city unidentified.) It is even easier to stop thinking of Wuhan are the birthplace of COVID (rather than the site of the first super-spreader events) when you recognize that in December 2019, the virus traveled unnoticed to France, was transmitted from one patient to another there, and disappeared. Given that the virus got to France unnoticed in December, it certainly could have gotten from South China to Wuhan unnoticed in November. You may also remember that there were COVID cases in California and Washington in January that went unidentified for several months even though US doctors were alert and knew what to look for at that time. I don’t want to say it rudely, but the idea that SARS-CoV-2 originated in a Wuhan laboratory resembles a conspiracy theory – driven by bias against China, the Communist Party’s lack of transparency, and a desire to blame someone else for our failures, Ron Graf \| January 3, 2021 at 9:42 am \| Frank, I agree that Wuhan was not necessarily the origin of the virus. However, the Chinese could realize this, which makes it curious to not allow the international community to trace the origin or find it themselves. Instead, they tried (unsuccessfully) to place the origin as the wet market. We know now that the cluster at the wet market was “just a coincidence” in looking similar to the 2002 SARS outbreak. You pointed out that China destroyed the RNA samples that would have aided in tracing the origin of a deadly threat in their own backyard that supposedly is still lurking. There is only one logical reason for doing this I can think of. After all, you pointed out that the storage of the virus has little risk compared with the benefit. Your information about the NIH is a different story from what I read and would appreciate the link. I believe the NIH determined in 2013 that the benefit of making chimeras to study was NOT worth the risk, considering the lab accidents that had been documented at the time. The only reason that Baric’s WIV chimera research was allowed to continue was that he specifically lobbied to have his research grandfathered from the ban. My personal hunch is that he wanted to prove the effectiveness of Remdesivir, which U of NC was partnered on. His paper acknowledged the failure of tried antivirals on the chimera and also that the chimera was even more viable than expected and thus more risky than feared. You are not disputing that the Chinese military was doing bat virus research in recent years and that they took control of the WIV when Covid hit. The Chinese military’s theory on origin, BTW, includes the US military. All this said I realize that half the people will see these facts as only evidence of conspiracy theory. Their reading of the admittedly closed and paranoid Chinese authorities is that they cover up everything reflexively, and since this behavior is normal it’s not suspicious. Ron Graf \| January 5, 2021 at 12:02 pm \| Here is the article that Tucker Carlson pointed out last night on the likely lab origin of CoV2. This very well-researched New YorK Magazine article published yesterday shows the history of the gain of function research and its strategy: to create human pandemic viruses before nature can in order to keep them trapped in a lab where they could be studied. The gamble was that we could create safe and effective anti-virals and vaccines before we would need them to address a natural pandemic. Depending on whether you were a virus-engineering expert or not seems to dictate one’s opinion on whether this strategy was sound and whether the Covid-19 pandemic proves more gain of function research, (making nasty human transmitted viruses in the lab), is called for or not. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html?utm_source=tw&utm_medium=s1&utm_campaign=nym Franktoo \| January 8, 2021 at 12:15 pm \| Ron Graf asked about this article in The New Yorker on the origin of SARS-CoV-2. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html?utm_source=tw&utm_medium=s1&utm_campaign=nymasked about this This article is grossly misleading. I researched this stuff about six months ago, but haven’t retained complete references. If you want to know what to trust, look up primary sources of information using Google scholar and full texts of government documents. Especially when dealing with sensational subjects! One useful phrase is “gain of function” “pathogen”. The link below MAY be the first article alerting the scientific community to the unnecessary danger posed by these experiments: https://doi.org/10.1371/journal.pmed.1001646 “From the conservative estimate of the rate of laboratory-associated infections of two per 1,000 laboratory-years [3],[16], it follows that a moderate research program of ten laboratories at US BSL3 standards for a decade would run a nearly 20% risk of resulting in at least one laboratory-acquired infection, which, in turn, may initiate a chain of transmission. The probability that a laboratory-acquired influenza infection would lead to extensive spread has been estimated to be at least 10% [19]”. The Wuhan lab is BSL4, safer than BSL3. The odds of an accidental release from this lab in October or November 2019 are minuscule. If I understand correctly, the cumulative risk from many labs doing such experiments over a long period of time prompted the NIH to shut down all gain of function experiments in potentially pandemic pathogens for almost three years. The National Academic of Science/NRC held workshops, did a full study of the risks and benefits, and published a book/online resource on the subject and the NIH ended the pause in such experiments in 2017. https://books.google.com/books?hl=en&lr=&id=QJ__CAAAQBAJ&oi=fnd&pg=PT14&dq=danger+of+gain+of+function+pathogen+studies&ots=PktaZAjjEk&sig=ijisxLz99M75JwSYsOZzEFWMuCA#v=onepage&q=danger%20of%20gain%20of%20function%20pathogen%20studies&f=false China did have problems with two accidental release of SARS-CoV-1 from labs around 2005, and publicized them to publicly punish those responsible. Personnel from the US Embassy visited the new BSL4 lab after it opened and sent a report, which was quoted out of context by many. The full text of that report is now mostly available. The biggest concern was that the Chinese government didn’t want to authorize working with the kind of dangerous pathogens the facility was built to study. They were being too cautious and holding back science, which is not surprising given the accidental releases made a decade earlier. https://www.washingtonpost.com/context/read-the-state-department-cable-that-launched-claims-that-coronavirus-escaped-from-chinese-lab/2b80aef2-f728-4c36-8875-3bf6aae1d272/?itid=lk_interstitial_manual_12 For a rational discussion of origins of SARS-CoV-2, see the link below, which dismisses genetic engineering. Others disagree, but I don’t claim to have read them all. China-bashing is popular. If others don’t discuss and refute the rational in this article, I’d dismiss them. Somewhere there is also an official consensus statement from the US Intelligence Community (based on the experts they consulted) claiming SARS-CoV-2 wasn’t genetically engineered, but others in the Trump administration find China bashing career-enhancing. Also from WHO. IMO, China’s secrecy tell us nothing. China releases information when it helps the Communist Party and hides anything that could hurt the party. If the Wuhan Seafood Market and the (live) wild animal trade played any role in the origins of this pandemic, the Chinese government will be guilty of extreme negligence in not suppressing the (live) wild animal trade. The SARS-CoV-1 outbreaks involved the (live) wild animal trade, the danger was well known, and the Communist Party didn’t end it. So IMO they destroyed all of the animals at Seafood Market and sanitized it to ensure that no one could prove whether or not that market played a role. I don’t think the government knew whether or not that market played a role. Protecting the Communist Party from public accountability is more important than trying to find out the truth. If SARS-CoV-2 escaped from a virology lab or was part of a biowarfare program, the Chinese government isn’t going to tell us the truth about that either. We can draw no reliable conclusions from Chinese secrecy, but we can use their secrecy to make them look bad. (The above paragraph is merely opinion.) Every other viral pandemic in history has originated or passed through animals that live close to man. Given that you accept that COVID could have traveled from bat-infested Southern China to Wuhan without being detected, there are no inconsistencies in the theory it originated where expected, and someday we will find a close ancestor of SARS-CoV-2 in the wild. The existence of one viable theory doesn’t mean alternative theories aren’t possible, it just means they aren’t necessary to explain what happened. (If one wanted to theorize that SARS-CoV-2 originated in bats in the vicinity of Wuhan, that theory would be problematic because there aren’t many bats around Wuhan.) While the Chinese military is certainly conducting defensive biological warfare programs and may or may not be conducting offensive programs, they are doing it at some secret location that US Embassy personnel never visit. The people doing that research do not collaborate with Westerner and sometimes receive funding from them. In other words, the Wuhan institute and Shi were not involved (IMO) niclewis \| December 29, 2020 at 1:23 pm \| Reply Ron, I share your difficulty in working out exactly how it occurs. But I haven’t found any holes in the analysis in the van Dorp et al Nature paper that concludes no mutation that has arisen at least 3 times, including spike gene mutation D614G (at position 23403), causes significantly increased transmissibility. Ron Graf \| December 30, 2020 at 10:49 am \| One explanation I can think of for a variants to dominate without being more infectious is that mutability might not be uniform across the virus’s genome. In other words, there could be genetic factors that favor stability in certain random base pair structures over others even though these factors do not affect the transmissibility. One way to prove this would be to find instances of variants arising independently, not because of lineage. The logical driver would be genetic stability. Franktoo \| December 31, 2020 at 5:27 am \| The “right” way to find out if and why this new variant is more transmissible is in a laboratory, not the field. 1) You an add an equal mixture of two viruses to a cell culture experiment and see if one virus gets into cells and replicates faster. 2) If you allow the viruses to bind, but wash they away before most enter, you can tell if one virus binds more tightly or enters more quickly than the other. 3) You can also see if one virus replicates to much higher levels than another. Some viral proteins are involved in suppressing the initial innate immune system response to infection. Does one strain reproducibly induce lower levels of interferon in patients or perhaps animal models? Other none structural proteins are transported into the nucleus and shut down normal cellular process that resist takeover of a cell by a virus. The key mutations that make a strain more transmissible by this mechanism obviously will be found in these other viral proteins (non-structural proteins), not the spike protein. If important differences between two strains aren’t found in the above assays, then one might expect both strains to produce similarly high levels of viral load in patients, though I have the impression that repeated swabs don’t give very tight data on viral load. If both viruses replicate equally well, then they could differ in the ability to get out of the patient as droplets or aerosols. Coughing and runny noses are great mechanisms for getting out of one patient and infecting another. A strain that produces more severe coughing or sneezing would have a transmission advantage. Finally, there is the mystery of what makes a super-spreader? Obviously if a viral strain makes it more likely a victim will be a super-spreader, it will be more transmissible. Without knowing what makes a super spreader, further speculation is worthless. Epidemiologists are looking at the end result of an extremely complicate process with complicated mixture of variants and mutations. In the lab, one can investigated individual steps in this complicated process and perhaps pinpoint what is different. Scientists find that pig and fowl farmers are frequently asymptomatically infected with novel strains of swine or avian flu. Those strains aren’t well adapted enough to growing in human cells to high enough viral titer to have a decent chance of being transmitted by droplets or aerosols from one human to another. The mostly likely way a virus becomes more transmissible is probably its ability to replicate more efficiently inside patients. Ron Graf \| December 31, 2020 at 9:26 am \| Frank, thanks for your inciteful comment. I would also combine your points to expand your conclusion that transmissibility is the product of all these factors, cell binding, immune suppression or evasion, replication efficiency, producing the highest viral load to the least amount of symptoms that would prevent that host from interacting with others. Evolutionary forces thus drive the virus to be less and less incapacitating but more and more infectious to the host species. This is why most viruses can’t jump and propagate in the non-host species, but if they do they are usually more harmful. That NIH scientists felt that making lab chimera bat-human viruses was too dangerous to do in the USA but fine to fund Chinese research was nuts. Ron wrote: I would also combine your points to expand your conclusion that transmissibility is the product of all these factors, cell binding, immune suppression or evasion, replication efficiency, producing the highest viral load to the least amount of symptoms that would prevent that host from interacting with others. However – if there are significant differences between strains – they are due to one discrete mutation. Combinations of mutations aren’t necessarily passed on, most strains die out when they aren’t passed on. Remember, most infected patients infect no one else and their variant dies out. Super-spreaders do most of the transmission and most “survival of the fittest” is mediated only through a small fraction of the population. My brain is struggling with this concept. The video linked by Joshua below explains is a more authoritative and sophisticated summary of what I was trying to communicate. https://judithcurry.com/2020/12/29/the-relative-infectivity-of-the-new-uk-variant-of-sars-cov-2/#comment-937851 Joshua \| December 31, 2020 at 5:40 pm \| Frank – I would note that virologists caution about using the term “strain” mesocyclone \| December 29, 2020 at 10:52 am \| Reply Nic, thanks. I do take a bit of issue with: “does not currently appear to represent a serious increase in the menace posed by SARS-CoV-2, even in the worst case that its higher observed growth rate is entirely due to increased transmissibility.” With some areas in the US (and other countries) hovering close to hospital saturation, it would take little increase in transmissibility to push them over the threshold, substantially increasing the CFR (and also deaths from denied medical care for non-COVID patients). climatereason \| December 29, 2020 at 11:30 am \| Reply mesocyclone If you look at this link you will see within the article some very useful charts, one of cases per day and one of deaths per day https://www.dailymail.co.uk/news/article-9095269/England-needs-national-lockdown-prevent-catastrophe-January-February-SAGE-warns.html We should by now be seeing a sharp upturn in deaths in response to more cases from 2 or so weeks ago. That will help determine if the new variant is not only more easily caught, but that it causes deaths at the same rate as the previous version, or whether whilst being easier to catch it is not as deadly niclewis \| December 29, 2020 at 12:52 pm \| Reply mesocyclone, I was thinking in a UK context, and more in terms of how much more difficult it would be in terms of required measures to keep Rt down to 1 ,given the new variant, than what the effect on hospital availability would be if no further measures had been or were imposed in response. mesocyclone \| December 29, 2020 at 1:11 pm \| “I was thinking in a UK context, and more in terms of how much more difficult it would be in terms of required measures to keep Rt down to 1 ,given the new variant, than what the effect on hospital availability would be if no further measures had been or were imposed in response.” Thanks, understood. I’ve seen a narrative developing in the media along the lines of “more transmissible but not more deadly, nothing to see here, don’t be alarmed,…” That concerns me, and it seems to be encouraged by some in the medical community. It will be interesting to see what we learn about the actual change in Rt as a result of this or other variants. Although, I guess strictly speaking, it’s a change in R0 that reflects in Rt. Of course, R0 can’t be measured at this point, and changes in Rt due to transmissibility changes are hard to disentangle from changes in behavior. aporiac1960 \| December 29, 2020 at 2:53 pm \| Reply “With some areas in the US (and other countries) hovering close to hospital saturation, it would take little increase in transmissibility to push them over the threshold” I don’t know the situation in the US, but in the UK the increased Covid load on hospitals in the current ‘wave’ is largely a result of different admission criteria; hence, for example, the much higher survival rate (better treatment is a factor, but is not a sufficient explanation). During the first wave in April the fear that hospitals would shortly be overwhelmed meant that hospital managers were not allowing admissions unless you were already critically ill. The largest proportion of cases at that time were in care homes, where by-and-large they were left to cope as best they could. Certainly in the UK, hospital and ICU occupation for respiratory problems are at normal levels for the time of year despite Covid. The NHS always has a “winter crisis” and this winter is no different. Normally, influenza is identified as the big killer. This year it appears to have been displaced by Covid. One theory is that public health measures put in place for Covid have reduced the spread of the ‘flu’, thereby reducing those numbers. Hopefully that is the case, rather than people who would otherwise die from influenza simply being killed by Covid instead. Certainly in the US, COVID mitigation measures have dramatically reduced influenza. The hospital statistics I follow the most closely are for Arizona, which at the moment is one of the worst states in terms of positive tests per capita. Our hospitals and ICU’s are over 50% COVID19, with well under 10% of capacity left. This is in spite of the fact that they are limiting some normal hospital care, and people are avoiding tests and procedures on their own because they don’t want to be exposed. This means that it wouldn’t take a large rise in cases to create a crisis. In fact, our November rate of increase had the universities forecasting a hospital crisis by Christmas, with people being denied necessary care – triaged to die. That didn’t happen – yet – because our rate of positive cases has plateaued. But… hospitalizations are still rising, and the only reason the ICU’s aren’t overloaded (state wide – some are full) is because the number of non-COVID19 cases is declining. I presume that is due to postponed care. In other words, they are using up the margin. 59% – ICU usage for COVID19 32% – ICU usage for non-COVID19 9% – ICU availability Contrast this to early October: 7% – ICU usage for COVID19 71% – ICU usage for non-COVD19 22% – ICU availability Andrew Williams \| December 29, 2020 at 11:08 am \| Reply PHE update: https://twitter.com/jcbarret/status/1343863090279043073?s=21 Wagathon \| December 29, 2020 at 11:10 am \| Reply Instructive too, the reaction to the news of the supposed increased virulence of the UK strain when we learn not long after that the strain is already everywhere and has been for a while along with a hundred others which we learn is totally expected based on how all viruses behave… Alan Lowey \| December 29, 2020 at 11:48 am \| Reply This is the simplistic narrative that we are up against: “Climate experts are not being listened to despite the coronavirus pandemic highlighting the importance of following science, the environmental activist Greta Thunberg has said.” https://amp.theguardian.com/environment/2020/dec/29/we-cannot-make-it-without-science-greta-thunberg-says-climate-experts-are-being-ignored Russell Seitz (@RussellSeitz) \| December 31, 2020 at 1:34 am \| Reply You call that simplistic? What of the still rising death tolll from climate ignorami touting crank and downright dangerous Covid cures, here and elsewhere, over the last ten months ? https://vvattsupwiththat.blogspot.com/2020/06/aquarium-cleaner-stocks-crash-on-covid.html Alan Lowey \| December 31, 2020 at 2:01 am \| The Barrington Declaration detailing the alternative strategy was written by highly regarded professional epidemiologists. ‘Climate ignorami’ are the mainstream scientists who are locked in groupthink and disregard past climate cycle inconsistencies with theory. Gravity theory isn’t settled therefore climate science isn’t settled. Matthew R Marler \| December 29, 2020 at 2:49 pm \| Reply Nic Lewis, thank you for the essay and responses to comments. Mike Jonas \| December 29, 2020 at 3:26 pm \| Reply Nic Lewis – thanks for all your investigation and detailed explanation. If the new strain is no more transmissible/infective than other strains, would it be correct to say that the newly increasing (‘second wave’) numbers would be about the same regardless of the existence of a new strain? You say “Confident claims by the UK government scientific advisers that the higher growth of B.1.1.7 is due to increased transmissibility are misplaced; it could be partly of wholly due to other factors”. There is a suggestion of what those ‘other factors’ might be for another variant – “resumption of travel across Europe, and lack of effective screening and containment may explain the variant’s success”. Do you have any idea what the ‘other factors’ might be for B.1.1.7 in the UK? [if you did in fact say what they might be then I missed it] niclewis \| December 30, 2020 at 3:58 am \| Reply Mike Jonas – I’m afraid that I don’t know what ‘other factors’ might explain the rapid growth of B.1.1.7. And I’m not saying that it necessarily is due to other factors. Rather, I’m pointing out that, since other variants have achieved similar success but are now thought not to be significantly more infective, it is wrong for NERVTAG to make a ‘high confidence’ finding that B.1.1.7 is substantially more transmissible. The contact tracing analysis published by PHE since I finalised my article is more direct evidence that is suggestive of B.1.1.7 actually being more transmissible, but differential geographic growth or some other factor may account for at least part of the contact attack rate difference found. According to the latest PHE report (https://bit.ly/3aThMAX), infectivity of the new variant compared to the old based on Test & Trace data is 15% versus 10% (proportion of those identified as having being exposed who subsequently go on to test positive). There is no distribution data so it’s not possible to see whether there are any differences in the pattern of spread. Yes, I’ve seen that too. It’s a great pity that no regional breakdown is given. aporiac1960 \| December 29, 2020 at 4:48 pm \| Also missing is a breakdown of the people/households the spread comes from. I’d like to know whether the averages reflect the typical pattern, or whether there is wide variability. Contrasting these patterns between the two Covid variants would also be interesting, and would certainly be useful to know when considering policy. Joe - the non epidemiologist \| December 30, 2020 at 11:30 am \| Aporiaci1960 comment – “Also missing is a breakdown of the people/households the spread comes from. ” That is a valid question, ie where are the environments where covid is actually spread. Absent the areas where there is a complete hard lockdown, the mitigation efforts seem to have only minor effects on the trajectory of the viral spread. . niclewis \| December 30, 2020 at 10:31 am \| Reply According to ONS user-requested modelling of development of the new variant’s prevalence relative to that of other variants by region (https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/adhocs/12708covid19infectionsurveyorf1abnpositivityrates), the advantage in weekly growth of the new variant from 9 November to 18 December varied between 1.12 and 1.58, with an average for England of 1.49. (The proxy used is less reliable prior to mid-November.) This daily data is for prevalence not incidence, so represents some sort of moving average of incidence over the last 10-14 days or so. It’s not obvious what would account for such widely varying regional growth rate advantages. The ONS modelling could be wrong, of course. The advantage in weekly growth of the new variant correlated quite strongly both with its prevalence on 9 November (r=0.56) and with the log growth rate since then in the non-variant prevalence (r=0.69). Not sure why that should be the case. Pingback: Latest News – Lockdown Sceptics Pingback: Lockdown sceptics:Fact Check Fail;“If The New COVID-19 Strain is More Transmissible, Why Isn’t It Taking Over in Every Region?” – naufrage/sauvetage Pingback: The relative infectivity of the new UK variant of SARS-CoV-2 – Watts Up With That? Pingback: The relative infectivity of the new UK variant of SARS-CoV-2 \| Phil Salmon \| December 30, 2020 at 11:10 am \| Reply In the UK intensive care wards are again being overwhelmed with covid19 patients as in the spring. Therefore stronger quarantine and lockdown measures are needed, it doesn’t matter what the R numbers are or the details of the virus strains. The fact that we are on our third lockdown should surely suggest they don’t work? Intensive care wards are overwhelmed EVERY winter and patients treated in corridors when there is a serious flu outbreak. We have far too few beds per 1000 of population and take no account of the rapidly rising and ageing population. Geoff Sherrington \| December 31, 2020 at 1:31 am \| climatereason. In Australia many people think that lockdowns work and much as they are disliked, we have next to zero cases week after week. Tight control of movement and rapid, deep contact tracing with quarantine are, for now, showing how one outburst (State of Victoria, last half of 2020) can be reduced and for the other States, held to near zero. Like under 10 new cases a day for populations of 10 million or so. Though, one does wonder how long the discipline will be effective when other countries have got Covid so widespread. Joe - the non epidemiologist \| December 30, 2020 at 12:43 pm \| Reply Phil’s comment – “In the UK intensive care wards are again being overwhelmed with covid19 patients as in the spring.” Your data point lacks context. A full comparison will shed some light on your statement. for the period 2016 through 2018 – What was the total # of ICU beds by month What was the usage of ICU beds by month What is the # of unused beds by month. what is the total bed capacity and usage by month How much of the change is seasonal, Without context, your statement is meaningless and typical of the followers of Covid-19 Freakout science. I don’t think that’s true. They weren’t overwhelmed in the spring, for a start. And I’ve read that just before Christmas hospitals in England had fewer Covid patients, and fewer of them in ICU units, than in the spring, apart from in the South East and the East of England regions. Show me data to back up your claims, or will regard them as NHS etc. propaganda. And the NHS a) should have more ICU capacity now, as they knew a 2nd wave might be coming and they’ve had 6 months to boost capacity; and b) doesn’t need as many ICU beds per COVID patient now as (i) they’ve got better drug treatment to avoid cases become very severe and (ii) ICU is usually only really needed for Covid patients who are being mechanically ventilated, and a far lower proportion of them are being ventilated now than in the spring (in many cases it has been found harmful to do so). Tonyb \| December 30, 2020 at 1:33 pm \| You don’t need to have too long a memory to see that uk hospitals were overwhelmed in 2018 This time with an Australian mutant variation of flu. Depressingly familiar especially as it says it thought the 2017 season was the worst ever for overcrowding. so that is 2 years in a row, https://www.dailymail.co.uk/news/article-5229733/Thousands-NHS-operations-cancelled-winter.html niclewis \| January 1, 2021 at 11:34 am \| Agreed, although it depends on what one means by ‘overwhelmed’. NHS hospitals often operate very near no nominal capacity limits in the winter and I’m not sure that everyone would regard cancelling some tens of thousands of non-urgent operations as being ‘overwhelmed’. mesocyclone \| January 1, 2021 at 11:48 am \| “I’m not sure that everyone would regard cancelling some tens of thousands of non-urgent operations as being ‘overwhelmed’.” While one can object to “overwhelmed” – it is certainly a serious situation when such measures are undertaken. BTW, here in Arizona, the largest hospital chain announced the cancellation of all non-urgent procedures as of today. Joshua \| December 30, 2020 at 1:08 pm \| Reply https://zeynep.substack.com/p/a-counter-argument-against-public (trigger warning, some criticism of rightwing weaponization of uncertainty at the above link) But more to the point: -snip- …the well-known virologist Vincent Raccaniello disagrees with epidemiologists that epidemiological data is high quality evidence for the novel phenotypic traits in the worrisome SARS-CoV-2 variant being tracked in the UK. Thanks, Joshua. I thought that darij’s critique of Matthew Smith’s incredibly lengthy and political ‘Counter-Argument Against Public Advocacy’ made good sense. niclewis \| December 30, 2020 at 1:21 pm \| https://zeynep.substack.com/p/a-counter-argument-against-public/comments#comment-952463 Yeah – Smith’s piece was waaaay to long. And some of the political aspects were hyperbolic, IMO. But there were some reasonable points, imo. And I also liked darij’s intro to Smith’s piece so I look forward to reading his critique. oops. Confused zeynep with darij. darij made some, IMO, rather obvious points, but IMO in balance reflected a similar imbalance as Smith’s piece. I’m looking forward to zeynep’s piece. Such is the situation you get when people are “motivated” in their arguments. Chebyshev \| December 30, 2020 at 11:19 pm \| Reply Joshua is the best in the business of wrapping appeal to authority in logical sounding word salad filled with “snips”. Alan Lowey \| December 30, 2020 at 1:28 pm \| Reply A beacon of light at the end of the tunnel: Oxford University/AstraZeneca COVID-19 vaccine approved https://www.gov.uk/government/news/oxford-universityastrazeneca-covid-19-vaccine-approved The fresh veg at my local Lidl were noticeably sparse and shelves emptier than usual today. It’s a trend that I expect to continue. No doubt, there’ll be something to eat, just not necessarily what you’re used to. climatereason \| December 30, 2020 at 1:36 pm \| Reply Our local fruit and veg shelves are bulging. Perhaps you are in one of those areas where transport is difficult due to snow? Or perhaps it’s just people stocking up ready for new years eve? People went completely mad with food buying for Christmas especially bearing in mind the supermarkets were only shut on the day itself. Alan Lowey \| December 30, 2020 at 1:55 pm \| I’m in the south east with no snow. I hope I’m wrong but it’s happened before in this store – panic buying. I might have to get there early in the morning to get what I want. I’ll let you know come January. Alan Lowey \| December 31, 2020 at 3:54 am \| Reply UK government declares new variant emergency lockdown measures: sub \| December 31, 2020 at 5:35 am \| Reply it is like a gas rushing into a vacuum! the strain is spreading because of bad behavior into populations that are naive to the virus. public health guidelines still defeat the virus. It is amusing to see so many intellectuals discovering all of a sudden that things like viruses exist and that they mutate! And also the fact people die. In most parts of the world 80 year olds dying are celebrated with feasts. Ragnaar \| January 1, 2021 at 12:20 pm \| Reply It seems there are many countries that haven’t defeated the virus. Governments solves all kinds of problems. Poverty, housing, education. Wagathon \| December 31, 2020 at 2:53 pm \| Reply We’ll never know the hours that the Left doubtless invested, trying to link the virulence of civid19 to CO2 Pingback: The relative infectivity of the new UK variant of SARS-CoV-2 \| awarecitizen.com Pingback: The relative infectivity of the new UK variant of SARS-CoV-2 ⋆ 10ztalk viral news aggregator Pingback: The relative infectivity of the new UK variant of SARS-CoV-2 \| altnews.org Alan Lowey \| January 1, 2021 at 9:26 am \| Reply Katie Hopkins makes a good case saying MSM is spreading unnecessary fear about hospitals filling up with covid patients when in reality number of available critical beds is reduced due to self-isolating staff: Joshua \| January 1, 2021 at 11:47 am \| Reply A real peach, that one. Exactly who I thought if turning to first when I heard about coronavirus. https://en.m.wikipedia.org/wiki/Katie_Hopkins Gotta say, Alan, there seems to be no place took low for you to stoop. Alan Lowey \| January 1, 2021 at 12:05 pm \| But her data is correct though? Joshua \| January 1, 2021 at 1:12 pm \| My guess is that its far more complicated than how she’s portraying it. Further, the condescending contempt from her dripping about healthcare workers self-isolating at home is repugunant. Further, she acts as if the increased spread and healthcare workers isolating at home could be decoupled. That’s nuts. niclewis \| January 1, 2021 at 3:34 pm \| Reply “she acts as if the increased spread and healthcare workers isolating at home could be decoupled. That’s nuts.” Nonsense. Testing NHS staff who would otherwise be at home isolating with a rapid lateral flow test before work, every day (or maybe even every two days) would ensure that they were most unlikely to be infectious (even if they would be positive by PCR test). Note that the NHS has an incredibly high sickness absence rate even excluding COVID related absence. About 4% overall, and 6% for Hotel, property & estates staff! Much of it is ‘psychiatric’ illness. Maybe this is typical for a public sector organisation; it would be highly abnormal elsewhere, I would have thought. Joshua \| January 1, 2021 at 5:29 pm \| Reply The PCR testing regime is far from perfect. If I’m not mistaken, I was the first person in these threads to loudly promote antigen testing as a public health surveillance (rather than treatment) methodology. Nonetheless, everywhere, the ebb and flow of positive PCR tests has been followed by a proportional ebb and flow in hospitalizatons, ICU admissions, and deaths. You have tried to trot out this “nonsense” before and it’s quite remarkable that you haven’t learned the lesson yet. You tried it with Sweden and failed miserably. Do you remember when you tried to dismiss the spike in positive tests as a blip?. More then once. And wrongly tried explain away significance of the spike in positive tests by effectively ignoring the consistent lag between testing outcomes and trends in morbidity and mortality? It isn’t just you. We’ve been hearing this nonsense about decoupling spikes in positive PCR tests from corresponding spikes in morbidity and mortality since early summer in the US. But predictably, the following corresponding spikes in hospitalizations, ICU admissions, and deaths did not diminish in the least the inane babbling about how positive PCR tests are irrelevant. The “nonsense” about the “casedemic” continues unabated. dpy6629 \| January 2, 2021 at 1:39 am \| Reply You see what Joshua is doing here is what he always does. He tries to make a general point with no data supporting it and no statistical analysis. Just psuedo-science. It would be pathetic if he wasn’t also easily proven to be wrong. Positive tests do not correlate well universally with hospitalizations and deaths. A counterexample is New York now and New York in March and April. Positive tests are 25% higher now yet deaths are a factor of 8 lower. Compare Germany and the UK. There is no universal valid relationship here because positive tests are a strong function of the number of tests performed which is strongly dependent on having a big surplus of test kits. Further is later comments, Josh the house cat, tries to attack the elephant’s ankles by claiming that PFR’s are now higher than Willis predicted this summer. But everyone has been way off about this pandemic and Josh has given no predictions at all. He lacks the scientific and statistical knowledge to make a credible prediction. Why is Joshua showing up here to bite the ankles of his scientific betters? Because this is the only venue where he is allowed to post such nonsense and not get moderated. If the estimated logarithmic rate of decline in weekly COVID-19 deaths in Sweden seen over the last six weeks continues, only about 1,100 further deaths would occur. That would bring total deaths up to approximately 6,400, or 0.06% of the total population. Of the first 4,500 deaths, some 40% involved people living in care homes,[16] a slightly lower proportion than earlier in the epidemic. To date, the average age at death was 82, and in only 6% of cases did a death not involve a co-morbidity (other health condition). Notwithstanding that a month ago antibodies were only detected in 6.3% of the Swedish population, the declining death rate since mid-May strongly suggests that the herd immunity threshold had been surpassed in the three largest regions, and in Sweden as a whole, by the end of April. In the absence of a change in trends, it seems likely that the epidemic will peter out after a thousand or so more deaths, implying an overall infection fatality rate of 0.06% of the population (0.04% excluding COVID-19 deaths of people in care homes). This is broadly comparable to excess deaths from influenza infections over two successive above-average seasons, such as 2016–17 plus 2017–18.[17] The absence of a lockdown order, with the government largely trusting people to make their own individual decisions regarding their behaviour, informed by their particular circumstances, has enabled life to continue with less disruption and reduction of people’s autonomy in Sweden than in most other western European countries. While this has also meant that COVID-19 deaths to date have been higher than in some (but not all) other countries in which a lockdown was imposed, the wider spread of the epidemic in Sweden means that the future COVID-19 outlook there is better. The herd immunity threshold is likely lower at present than it would be if people were behaving completely normally; it may also be seasonally lower. However, the continuing spread of infections since the peak of the epidemic, particularly among young people, should provide some margin of safety against its resurging when behaviour returns closer to normal and summer ends. That is, there is less risk of a second wave of the epidemic next winter. And if a second wave occurs, fewer measures should be needed to control it than in other countries. The only question at this point is just how far off your speculation was. What’s settled is that (1) you were way off, (2) you won’t acknowledge your errors, (3) will continue to double down on the same thinking that led to your errors (which is what happens when people don’t accept accountability for their errors). It’s not the making of errors that’s the problem. Creating toy models to simulate an incredibly complex reality with so many unknowns is bound to generate errors. I respect the skills involved in doing such modeling. I consider the attempts at the modeling to be important and I think that experimenting with the parameters is likewise important. The problem is (1) when the errors result from a disrespect for uncertainties as we had here and, (2) people duck accountability for their errors. More flim flam artistry from Joshua. Everyone knows (except Josh the pseudo-scientist) that herd immunity levels will be a strong function of the seasons for example as always happens with the flu. Herd immunity was likely reached this summer in many places. Then we had winter and people stayed indoors and in close contact with other people and R went up significantly. For the record, Ferguson and our own CDC were dramatically wrong in their predictions of the course of this epidemic. Franktoo \| January 2, 2021 at 3:11 am \| dpy6629: I respectfully suggest you look at real data somewhere. There were a trivial number of cumulative cases in North Dakota before September. By Thanksgiving, more than 10% of the total population had tested positive. (We don’t know how many people had mild or asymptomatic infections, but the early seropositivity studies suggested PCR testing was missing 6 to 15 cases for ever case detected. That lead to a low IRF and the mistaken claim that COVID is no more deadly that influenza.) Today ND’s cumulative cases amount to 12% of the population (14% in Bismarck), but the number of new cases has dropped dramatically. We don’t if approaching herd immunity played a role in suppressing the pandemic in ND or if fear or policy suppressed the pandemic. (ND hospitals reached “100% of capacity” in early November, so fear and restrictions could have been responsible for slowing.) Given the situation in ND, it is ludicrous to suggest the anywhere in the US reached herd immunity this summer with half as many cumulative cases as ND has today. For example, the pandemic is rebounding in NJ, which was badly hit this spring. Furthermore, herd immunity doesn’t vary with the season. Herd immunity means that no pandemic can grow exponential under “normal conditions” at any time of the year. mesocyclone \| January 2, 2021 at 12:04 pm \| “Today ND’s cumulative cases amount to 12% of the population (14% in Bismarck), but the number of new cases has dropped dramatically. We don’t if approaching herd immunity played a role in suppressing the pandemic in ND or if fear or policy suppressed the pandemic. ” I think SD is more interesting, because there were very few mandates, and they took place early in the epidemic yet SD’s epidemic didn’t really take off until months later. And then it peaked and subsided. I suspect, but don’t know, that immunity played a significant factor, since one could reasonably project that over 50% of the population had the infection. But… a very important point that people keep ignoring… whether or not a government imposes mandates, many people will change their behavior in ways that reduce the spread of the disease. And, it is very hard to tease those changes out. You can look at mobility and guess at some of it. But the rest? Joshua \| January 2, 2021 at 4:55 am \| Comment deleted as it duplicates the author’s next comment Dagnabbit! Lol. Is the population fatality rate “seasonal” also? Gomes says that a population can cross back and forth over a herd immunity threshold seasonally. But Nic reverse engineered from rate of infections 8 MONTHS ago to conclude that Sweden had reached a herd immunity threshold under more or less normal behavioral conditions. He posted pictures of young people partying in bars to say that some 10% or so of Swedes having been infected meant that under normal behaviors someone there who had never been infected would be unlikely to encounter someone who is infectious. Did he ever say, in the hundreds of words he wrote on the topic, that of course, it was quite likely thay when the season changed, the rate of identified infections would increase many-fold (depending on the acquisition rate) and people would start dying again at rates approaching the rate they had at the peak of the first wave? Well, lessee: That is, there is less risk of a second wave of the epidemic next winter. And if a second wave occurs, fewer measures should be needed to control it than in other countries. Well, nope! He even went so far as to say that herd immunity status would predict relatively few deaths going forward before the pandemic “peter[ed] out.” Is the pandemic pestering out a “seasonal” phenomenon also? Lol. Nic was wrong. He looked at some curves on a computer screen and thought they told him about the complexities of human biology and human behavior under highly uncertain circumstances. He disrespected unvertstinty, such as the potential that a seasonal effect in Sweden was maybe due in part to people traveling to vacation. homes for the summer? How do we know that? Well, by his erroneous projections about population fatality for one. It’s right there on your computer screen. But even more so, and more dangerously, because he tried to extrapolate from the temporarily low infection rate in Sweden to suggest that other countries follow Sweden’s policies even though in those other countries large populations wouldn’t be hanging out in summer homes in incredibly sparsely populated areas (or working from home at similar rates, or living in such small household sizes, etc.) “Herd Immunity” in the popular vernacular has come to mean that enough people have become infected and recovered or died that people can return to normal behaviors without it being lokely that they’ll encounter an active virus at levels likely to make them ill or die. And that the pandemic will “peter out” and not just temporarily slow down only to come back at a similar or possibly even accelerated rate in a different season. We have plenty of indicators that’s what Nic meant. But if it isn’t what he meant then it’s even worse, because that would mean he knowingly and misleadingly suggested that the pandemic would “peter out” and that people would no longer be getting sick and/or dying in the future at concerning rates if they went back to normal behaviors, even those in countries where the behaviors were VASTLY different than behaviors were in Sweden at the time. No, it would mean that he knowingly and misleafingly WRONGLY low-balled the number of Swedes who would die going forward. I don’t know Nic, but I doubt he’d do something like that. I’d rather think he just messed up due to under-estimating uncertainty. Lots o’ people do that. It happens. Did he, in fact, warn people NOT to over-interpret the temporary trends in Sweden to think that their having crossed a theoretical “herd immunity threshold” would suggest the pandemic had “peter[ed] out?” I’ll let you be the judge. Speaking of film-flam, your use of “herd immunity” is nonsense. Herd immunity is not a function of the seasons. It is true that an epidemic can run out of steam because of social distancing (related to seasons), but that really is not herd immunity. Yes, immunity might be a contributing factor – it has the exact same effect as lowing Rt. But it is not “herd immunity.” But Joshua’s use of the term “logarithmic” is very wrong. But then, he is not a math person. “Exponential” is closer to right. The trend, whether going up or down is exponential (or close to it – if immunity is changing, it diverges from exponential to some extent). Joshua \| January 2, 2021 at 12:56 pm \| > But Joshua’s use of the term “logarithmic” is very wrong. But then, he is not a math person. “Exponential” is closer to right. The trend, whether going up or down is exponential (or close to it – if immunity is changing, it diverges from exponential to some extent). Logarithmic? When is my “very wrong” use of the term “logarithmic?” Are you referring to when I was quoting Nic’s use of the term? meso – > Herd immunity is not a function of the seasons. The conceptualization that herd immunity is a function of seasons brings an example to mind for me. Suppose 100 people shipwrecked on an island. When they hit the island one person was sick and that person infected 2 other people and then those 3 people together then infected 7 more total (IOW, on average each infected person then infected more than 1 other person ). And as soon as those 10 got sick everyone quarantined and after 1 month no new illnesses surfaced. 90 people never developed antibodies because they were never infected. Would we say that the population of the island had reached herd immunity even though only 10% were ever infected? One more infected person traveling to the island could easily spark exponential growth of the virus and so it seems to me it wouldn’t be very useful to characterize the island’s population as having reached “herd immunity”. Yet that seems to be the equivalent functional definition that some of our friends are working from. It’s rather like saying that to reach herd immunity all we need to do is lock everyone up in isolation. Yet that’s exactly the kind of thinking they then turn around and say would delay the achievement of “herd immunity.” There doesn’t seem to be a consistent logic. When public health officials are talking about the need to have 75%+, or 50+ plus infections/vaccinations to reach “herd immunity,” they’re not talking about a rate that would easily explode again if there were relatively small changes in behavior. They’re talking about reaching a point where the likelihood of getting infected would be relatively small under normal behavior conditions. I thought this article was pretty good: dpy6629 \| January 2, 2021 at 6:52 pm \| Well Frank, I didn’t say that everywhere in the US reached herd immunity in the summer, just that many places may have. The point I was making is that Nic’s analysis may indeed have been correct on this score. I don’t know about North Dakota. I think places like New Jersey, New York and Pennsylvania are seeing a second wave. Since all have had strong restrictions in place since March, the only logical explanation is that they did indeed reach effective herd immunity (given their restrictions) in the summer when the epidemic almost died out. But with winter time R has increased so that there is a second wave and herd immunity fraction has gone up. If you have an alternative explanation I’d entertain it but my explanation I think readily explains most the course of the epidemic in states that were hard hit early. mesocyclone \| January 2, 2021 at 7:05 pm \| ” Since all have had strong restrictions in place since March, the only logical explanation is that they did indeed reach effective herd immunity (given their restrictions) in the summer when the epidemic almost died out. But with winter time R has increased so that there is a second wave and herd immunity fraction has gone up. ” You are abusing the term “herd immunity.” Qualifying it with “effective” doesn’t change that. You don’t know if immunity was a factor or not – only that the curve reversed itself. But, that can happen without any immunity at all. The herd immunity threshold is not some kind of universal constant. It depends on R the rate of transmission and that can vary strongly with the season, people’s behaviors, etc. Meso, Do you have an alternative explanation for why with essentially the same restrictions in place the whole time, the epidemic almost died out this summer and then a second wave developed this winter in the states I mentioned? That is incorrect. It is a constant of the disease, and is only meaningful in conditions where behavior is normal. Any other usage is unusual, and potentially very confusing. I suppose one could modify it a bit for different localities – where factors like humidity might be different. But, modifying it for hard to measure behavioral impacts is a bridge too far, and becomes tautological. It is true that a combination of immunity and behavior can result in Rt < 1.0 during the epidemic, but that is not "herd immunity" and the HIT has not been reached. It is also true that behavior changes alone can produce that same change to Rt. In fact, it is nearly impossible to disentangle immunity and behavior changes, unless you actually know how much immunity is out there. "Do you have an alternative explanation for why with essentially the same restrictions in place the whole time, the epidemic almost died out this summer and then a second wave developed this winter in the states I mentioned?" Alternative to what? A misuse of the term "herd immunity" and "herd immunity threshold?" If the epidemic died out and then reappeared in the same population, it is solid proof that herd immunity was never reached. As to why we have a second wave now, I am not sure. Some of it is certainly behavior – note that the presence or absence of government mandates is hardly a determinate of behavior. It is also possible that we already have enough of new strains with higher R0 to be a big factor, although I am certainly not confident of that. Another factor could be environmental – humidity changes, etc. But, you have to look at it one locality at a time, since environments and behavior vary substantially. Living in the Phoenix, AZ area, I am in a place where people are more outdoors during the winter, and more indoors during the summer. And yet, we had a huge peak in early July, and are now in the middle of an even bigger one at year end. So… did immunity cause the end of the July peak, and if so, why are things so much worse now? The best evidence is that the level of immunity in the population here was too low to turn the epic-curve around – and that includes random antibody sampling by CDC of our population (including my zip code) soon enough after the July peak that the antibodies should have still been detectable. You can generate good graphics of Arizona data at 91-divoc dot com. Yeah – “Effective herd immunity.” I love that. I’ve seen that before. It’s like they would reach “effective herd immunity” on the island in my example here: Which means not herd immunity at all, but a convenient way to say it’s herd immunity because of a lower rate of transmission because of circumstances that have nothing to do with herd immunity. So you don’t have to admit you’re wrong. > Meso, Do you have an alternative explanation for why with essentially the same restrictions in place the whole time, the epidemic almost died out this summer and then a second wave developed this winter in the states I mentioned? Behaviors changed. When you’re saying “effective herd immunity” what you’re saying is that behaviors changed. It’s not herd immunity in any meaningful sense. Are you going to explain where you found my ‘very wrong” use of the term “logarithmic”? No. I lost the context and it isn’t worth digging back up. Generally, if logarithmic is used to refer to the rate of increase or decline, it is incorrect. But in some technical discussions, logarithms are used – for example, viral loads. Yah, well, didn’t happen actually. I think you were reading a section where I was quoting Nic (I used italics but didn’t specifically note I was quoting him). You might want to take it up with him. Of course, you could do a search for “logarithmic” on the page if you think that wasn’t it. Atomsk's Sanakan (@AtomsksSanakan) \| January 5, 2021 at 3:01 pm \| @dpy6629 Re: “Since all have had strong restrictions in place since March, the only logical explanation is that they did indeed reach effective herd immunity (given their restrictions) in the summer when the epidemic almost died out. But with winter time R has increased so that there is a second wave and herd immunity fraction has gone up.” Herd immunity is about baseline conditions of R0 and thus, by definition, includes no additional behavior changes and no additional public health interventions above what would normally be present (i.e. conditions in the absence of the pandemic, such as during the same time of year in 2019). So you’re abusing the term “herd immunity” by re-defining it to apply under conditions of additional restrictions, i.e. additional public health interventions. It’s the same reason why Nic Lewis was wrong when he claimed Sweden, including Stockholm, reached herd immunity after additional restrictions. Even Gomes’ team tacitly admit this when they state the herd immunity threshold in terms of R0 (plus heterogeneity, where behavior changes and public health interventions are not examples of heterogeneity). “This quasi-equilibrium is maintained not because of herd immunity but because of changes in behavior. […] The peaks occur at levels of infection far from that associated with herd immunity. Post-peak, shoulders and plateaus emerge because of the balance between relaxation of awareness-based distancing (which leads to increases in cases and deaths) and an increase in awareness in response to increases in cases and deaths.” https://www.pnas.org/content/117/51/32764 “This allows us to “bend the curve” and predict temporary equilibrium states, far away from the equilibrium state of herd immunity, but stable under current conditions […]. Yet, these states can quickly become unstable again once the current regulations change.“ “In the simplest model, the herd immunity threshold depends on the basic reproduction number (R0; the average number of persons infected by an infected person in a fully susceptible population) and is calculated as 1 − 1/R0 […]. Early in the COVID-19 pandemic, as other countries in Europe were locking down in late February and early March of 2020, Sweden made a decision against lockdown. Initially, some local authorities and journalists described this as the herd immunity strategy: Sweden would do its best to protect the most vulnerable, but otherwise aim to see sufficient numbers of citizens become infected with the goal of achieving true infection-based herd immunity. By late March 2020, Sweden abandoned this strategy in favor of active interventions; most universities and high schools were closed to students, travel restrictions were put in place, work from home was encouraged, and bans on groups of more than 50 individuals were enacted. Far from achieving herd immunity, the seroprevalence in Stockholm, Sweden, was reported to be less than 8% in April 2020,7 which is comparable to several other cities (ie, Geneva, Switzerland,8 and Barcelona, Spain9).” “In idealized scenarios of vaccines delivered at random and individuals mixing at random, herd immunity thresholds are given by a simple formula (1 − R0) which, in the case of SARSCoV-2, suggests that 60-70% of the population would need be immunized to halt spread considering estimates of R0 between 2.5 and 3. A crucial caveat in exporting these calculations to immunization by natural infection is that natural infection does not occur at random.” https://www.medrxiv.org/content/10.1101/2020.04.27.20081893v3.full [with: https://www.medrxiv.org/content/10.1101/2020.12.01.20242289v1.full ] JC SNIP. I will continue to use the SNIP any time you refer to me or Nic Lewis in a content-free insult. You can now return to saying usual catchphrases like ‘your reply has too many words for me to read!’. 16/X But remember, it wasn't herd immunity that limited infections into larger populations and regions; those regions didn't reach HIT. Instead, it was behavior changes and/or public health interventions that limited infectionshttps://t.co/4AV88OeaPghttps://t.co/u2pARCkrDw pic.twitter.com/sd7lcoFrWk — Atomsk's Sanakan (@AtomsksSanakan) December 23, 2020 Re: "As an immunologist, I can say what you just wrote makes no sense and has been repeatedly debunked in the scientific literature." The ideologically-motivated epistemic trespassing we're now dealing with…https://t.co/pYqt6YrO3x pic.twitter.com/k1UK4CDfoQ — Atomsk's Sanakan (@AtomsksSanakan) November 28, 2020 niclewis \| January 2, 2021 at 11:29 am \| Reply As Joshua says, I wrote some months ago about Sweden: I accept that I underestimated – based on what I had read – just how seasonal COVID-19 would be. Greater infectiousness as colder autumn weather drew on appears to have raised the herd immunity threshold to above the existing level of population immunity. As a result of that, on top of an apparent gradual return during the summer to more normal social behaviour, particularly by young people, Rt rose from confortably below 1 to significantly above 1 – although to nowhere near the levels seen in the first few weeks of March – and infections rose substantially in October and November. Nevertheless, my caveated estimate of ~6,400 deaths caused by COVID-19 still looks fairly realistic. The best measure of such deaths is generally agreed to be excess mortality. Up to 6 December, excess deaths in 2020 (relative to the 2015-19 mean) appear to have been under 4,500 in Sweden (https://ourworldindata.org/excess-mortality-covid). Extrapolating recent trends suggests less than 5,500 excess deaths for 2020 as a whole. The epidemic isn’t over yet, of course, but COVID-19 cases and intensive care admissions show indications that the peak might now have been passed, although a further resurgence is of course possible. ” Greater infectiousness as colder autumn weather drew on appears to have raised the herd immunity threshold to above the existing level of population immunity. ” How to you explain the current US peaks in Arizona and southern California? It isn’t cold in either place – in fact, here in Arizona, winter is when we spend more time outdoors. And yet, our hospitals are filling up – to the point the Banner Hospitals, our largest hospital system, now prohibits all non-emergency procedures. Also, I wish you wouldn’t use “herd immunity threshold” in such a conditional way. That really isn’t what it means. Yes, anything that causes the epidemic to turn around acts mathematically the same way as the herd immunity threshold – it lowers Rt below 1.0. But, we could have an almost completely immunologically naive population have a peak and then a turn-around, without ever having much immunity. In fact, that happened in last spring in the US in most states. When the case rates turned, the total number infected was a tiny percentage of the population – way under 10%. Immunity had little to do with that turn-around. Take a look at this graph, and tell me where immunity was a factor: http://91-divoc.com/pages/covid-visualization/ Trying to put the graph in as an image: > Nevertheless, my caveated estimate of ~6,400 deaths caused by COVID-19 still looks fairly realistic. The best measure of such deaths is generally agreed to be excess mortality. This is the kind of dissembling that does your credibility no good You weren’t referring to “excess deaths” when you made your projection. Now you want to switch metrics because your estimation looks bad? Excess deaths as a metric has all kinds of complications and uncertainties as a way to measure COVID deaths, which is what you were estimating. But notice that you deal with none of them. Joe - the non epidemiologist \| January 2, 2021 at 3:46 pm \| Nic – Steve McIntyre mentioned a textbook on his twitter feed in the May June time frame which discussed the historical trends and trajectory of influenza over the various regions of the world over the last 150+ years. Do you recall the name of the textbook or the author (boyles? maybe?) niclewis \| January 2, 2021 at 4:07 pm \| Joe – I’m afraid not. Maybe searching Steve M’s twitter account feed would turn up what you are after. There is no dissembling involved here Josh. A prediction can be wrong in one sense and not wrong in another. Nic is perfectly entitled to point this out. In any case, predictions in an epidemic should be treated with skepticism as the equations are ill-posed and outcomes are sensitive to parameter values. What I am seeing here is that your obsessive disorder has returned. It wasn’t funny when you did it to Judith and its not funny now either. You always seem to pick people who are vastly more competent and adult than yourself. Being the cat scratching at the ankles of the elephant is inherently a dangerous disorder. matthewrmarler \| January 2, 2021 at 7:49 pm \| Joshua: You weren’t referring to “excess deaths” when you made your projection. He was referring to deaths due to COVID-19, the counts being variously estimated. The “excess deaths” counts provide one estimate. If you disagree that the excess deaths counts is the best estimate, what estimate do you think is the best? Granting that measurements are estimates of quantities that can not be exactly known, and that applied mathematics is simplified approximation to complex processes, Nic Lewis’s forecasts have been among the more accurate that we have read. Nic projected a number of deaths from Covid. He based in specifically on moving forward from a number listed as Covid deaths – not a number of excess deaths. He mentioned nothing about excess deaths. Now that it turned out that his projected number was very wrong. He wants to switch the metric that he’s using because it makes his projection look less bad. Excess deaths, based on a comparison to previous years, is obviously not the same thing as Covid deaths – which again, is what Nic talked about in his projection. Just as one obvious factor would be accounting for the obvious decrease in deaths from the seasonal flu that we’d see in previous years – as the result of interventions and behavior changes that targeted COVID. Of course, there could be factors that run in the other direction – such as increases in deaths in other areas because people were reluctant to seek out medical care – but in some ways those could be considered COVID deaths as well because people didn’t seek out medical care because there was a raging pandemic. But that’s all just bunch of related uncertainties. What isn’t uncertain is that Nic wanted to switch metrics mid-stream because he wants to make his projection look less bad than it was. Very disappointing. > The “excess deaths” counts provide one estimate. You boyz are hilarious. Obviously, measuring deaths because of COVID is complicated. Many people who are in the business of counting that type of thing say that the official numbers are likely undercounts, if anything. But that’s not really here or there. Nic started out with a particular metric and projected forward on the basis of that metric. Now he wants to switch metrics mid-stream because he wants to diminish the appearance of having been wrong. Excess deaths certainly bear some kind of relationship to COVID deaths – but it’s also likely to be a very complicated relationship. What’s clear is that they aren’t the same thing. “Excess deaths” is not an estimate of COVID deaths because obviously, there are many related variables that change contemporaneously within time span that’s being considered. You can’t just substitute one for the other as Nic is attempting to do. If he wanted to supply some kind of translation calculus that was scientifically calibrated, and verified, then he should go ahead and do that and put it up for scrutiny. It’s really hilarious to watch you boyz try to dissemble for him. He wants to switch metrics mid-stream (without even attempting to offer a a theory of how to calibrate the one metric with the other). It’s totally unscientific. But go ahead and defend it if you want. It’s amusing and it just goes to show how “skeptics” as a group have no claim to being unbiased in their analyses. jacksmith4tx \| January 2, 2021 at 11:02 pm \| There has been a sharp drop in deaths from almost all known circulating respirational diseases except from COVID-19 so teasing out meaningful information from excess death numbers will be tricky. Suicides, drug deaths, murders are up while life expectancy, family formation and child births have dropped. America is sick in many ways, sad. Joe - the non epidemiologist \| January 4, 2021 at 11:33 am \| Nic – I located the textbook – by Hopes Simpson. season and the epidemiology of Influenza. Interesting observation is that pandemics are very pronounced in the winter months for the regions north of 30degrees latitude (& south of 30S latitude). While historically between 29N to equator, there tends to be a moderately pronounced summer surge along with a somewhat moderate winter month surge. All of Europe is north of 35N. Dallas TX is 32N Houston, 29N. brownsville 26N, tallahassee 29n miami 26n. For the most part, the seasonal covid surges in the US and Europe are consistent with the surges documented in the 1981 era textbook. Except… parts of the south of the US had a substantial surge during the hottest weather, which died down, and then another surge hit in the winter. Arizona had what at the time was a news-making surge in early July. It faded away, but now we have an even worse surge at the start of January. So our two surges were at the hottest time, and the coldest. mesocycle – the moderate summer surge in AZ, TX al, ms, ga FL along with a stronger surge in the nov/Dec time frame is consistent with Hope-simpson’s analysis. 91-divoc shows AZ to have had a moderately hard surge in the summer and a harder surge in the late fall. Only difference from the Hope Simpson analysis is the AZ latitude is 32n-34n. I will note that CA, Oregon & WA seem to be anomalies to some extent Arizona’s summer surge was hardly moderate. It almost crushed the medical system before it abated. Most of the population (and cases) was in Maricopa County, which is at moderate altitude (upper Sonoran Desert) with all the population north of 33 degrees. The winter surge is quite a bit worse, so far. The medical system is under significant pressure, with the largest hospital chain banning all non-emergency procedures. Does the textbook offer an explanation for why we get these surges? In the winter, in the Phoenix area, people are outside more than in the summer, for example. Meso – comment – Does the textbook offer an explanation for why we get these surges? In the winter, in the Phoenix area, people are outside more than in the summer, for example. I havent gotten into the book enough to provide a good explanation, Though he does make reference to solar radiance/irradiance. I am unable to post the graph by latitude, though the image for the south of 30N shows the summer surge is approximately 2/3 of the winter surge while north of 30N has virtually zero summer surge. the significant deviation in the Hopes-simpson analysis is the 30n where as the deviation / dividing line seems to be approx 33n for Covid. (30S for the southern hemisphere) > Does the textbook offer an explanation for why we get these surges? Apparently Hope-Simpson speculated about vitamin D as a moderating variable. https://www.hindustantimes.com/india-news/covid-19-what-you-need-to-know-today/story-rTk7VOXzuK7dCYqb3iD1IO.html But this armchair patten matching about lattitude is just more amusing evidence of DK as a moderating variable in the relationship between political ideology and views on COVID. Franktoo \| January 2, 2021 at 6:13 pm \| Reply Mesocyclone wrote: “I suspect, but don’t know, that immunity played a significant factor [in the reduction in new cases in North Dakota since the peak around 1400/100000/day = 0.14%/day in mid-November to 250/100,000/day = 0.025%/day in mid-December], since one could reasonably project that over 50% of the population had the infection. But… a very important point that people keep ignoring… whether or not a government imposes mandates, many people will change their behavior in ways that reduce the spread of the disease. And, it is very hard to tease those changes out. You can look at mobility and guess at some of it. But the rest?” We’ve seen similar dramatic reductions in the Northeast this spring and the South this summer that we know haven’t been due to herd immunity for two reasons: the pandemic in these locations is surging now and cumulative detected cases there are much less than 10% (6% in FL, 6% in TX, 7.4% in AZ, 5% in NY, 5.5% in NJ). These spring and summer surges were obviously were not ended by approaching herd immunity. Limited testing capacity and changing standards for obtaining a test may have meant that undetected cases were a larger fraction of total cases (the ones resulting in immunity) were missed this spring, but probably not this summer vs this fall. Since dramatic reductions in new cases have occurred in the past because of fear and restrictions, the same factors could be at work in ND and neighboring states. I’m not sure how to personally judge the impact of changing restrictions, but I know GPS data from cells phones provides some information. In some locations, socio-economic factors, population density, risky jobs (meat packing plants), local politics or other unchanging factors may determine whether there are more cases in one county than a neighboring county. In those situations, one might expect to find a positive correlation between new cases and cumulative cases. However, once herd immunity becomes a major limitation in transmission to produce new cases, one might expect to find an inverse correlation between new cases and total cases. In NJ a month ago, there was a decent correlation between new and cumulative cases, R^2 = 0.6 and much weaker but not negative in ND’s counties. Unfortunately the correlation became somewhat stronger over the past month. Unfortunately, there is not much dispersion in the number of cumulative cases: 5-15% for all ND counties, 7-14% for counties over 10,000 people. Since I last looked, I see South Dakota is still behind ND with 11.3% cumulative cases, but three small counties have jumped to 21-22% cumulative cases. Earlier I found there was a prison in one of them (Bon Homme), so I’m not sure what to think about them. The hard hit county in Colorado in the news earlier I checked out turned out to also have a prison. (The death rate in these counties is about 50% higher than the state as a whole, but a dozen other counties exceed their death rate.) Buena Vista County in Iowa is up to 19% with the pandemic still raging (75 new cases/100,000/day. Crowley County, CO has 27% cumulative infected and I remember seeing a prison there. Bent County, 20.2% with an outrageous 314/100000 new cases/day (2%/week). There now seem to be outlier counties near 20% in many states. In general, the pandemic has moderated in the North Central US in parallel according to maps, but the cumulative cases associated with that moderation vary 2-fold. It isn’t obvious to me that herd immunity is playing a critical role in any of these reductions. I think a worst case scenario is that we are now missing one case for every one we detect. That would allow for some truly asymptomatic patients and some symptomatic patients not sick enough or interest in getting tested. I doubt we could be missing one case for every two or more we detect. If we were missing two cases for every one case we detect, I think herd immunity would be playing a more obvious role in places where percent cumulative cases is well into the teens and certainly at 20% – if any of those locations are “normal” and don’t have a prison. (One final possibility is that some naturally-acquired immunity fades in less than a year.). It is possible 40% or more of those younger “essential workers we intend to vaccinate before the elderly are already immune. ” I doubt we could be missing one case for every two or more we detect. If we were missing two cases for every one case we detect, I think herd immunity would be playing a more obvious role in places where percent cumulative cases is well into the teens and certainly at 20% ” The CDC thinks we missed a higher ratio than that in the past, and I’d be surprised if we aren’t missing at least half of the cases. It was my suspicion that we are missing quite a few that led to my supposition that perhaps SD might be showing the effects of herd immunity. That said, we really don’t know. We have seen similar reversals of the epidemic curve in other states where we know it was not due to herd immunity, including Arizona’s summer peak – one which got world headlines at the time, but one we have now well surpassed. I live in AZ, and frankly do not know what is causing our current record high cases. There is certainly a lot of mobility, based on my own observations. I keep hoping for the epidemic to subside here, but so far, it has not. Our government has not taken strong measures, and I have the feeing that Gov. Ducey is fine to let the disease keep killing people as long as the hospitals are not overloaded – he seems to believe that he can keep the economy going without a catastrophe. Unfortunately, they are teetering on the edge of a medical system overload, which would lead to triage protocols – put another way, leaving some people to die without the care they need. Our largest hospital chain (Banner) just announced cancellation of all non-emergency procedures in their hospitals. Franktoo \| January 2, 2021 at 9:53 pm \| Mesocyclone wrote: “Our government has not taken strong measures, and I have the feeing that Gov. Ducey is fine to let the disease keep killing people as long as the hospitals are not overloaded – he seems to believe that he can keep the economy going without a catastrophe.” I’ve been saying this for many months, since May if I remember correctly. Unfortunately, we don’t have the hospital capacity to get to herd immunity in a single surge and people eventually do get scared enough – when combined with public health measures – to cause the number of new cases to fall for awhile. The 1918-20 Spanish influenza apparently occurred in three major waves in most places, probably without fully reaching herd immunity (since avian flu became a seasonal flu afterwards). Since so many middle aged people died (from cytokine storm) during the Spanish flu, fear was a much stronger motivators than during the current pandemic and the number of new cases between waves was very low. The people who complain about our ability to model this pandemic are probably looking at longer range predictions. If decision-makers are motivated to prevent overflowing hospitals, they need accurate projections for about eight weeks. The people getting infected today will be coming down with symptoms and testing positive about a week from now and getting sick enough to be hospitalized two weeks from now. They will stay in the hospital for an average of two? weeks. For policymakers to be able to deflect an oncoming crisis in hospital capacity, they will need to have intervened as couple of weeks ago and the wiser ones probably start a week or two earlier. The modelers probably have a better idea (but not perfect) of how much various measures will slow transmission than they did this spring, and some idea of how much role fear/voluntary measures will help, but they may want to use the latter as their safety margin and not count on it. Policymakers worried about hospital capacity probably don’t need to worry the decay of a surge or how low the number of cases will go or when they will go back up. The need a 6-8 week warning of about a coming crisis. My state add 50% additional ordinary and ICU beds, but they may not have the staff to fully care for patients using this surge capacity. When states talk about % of capacity, it is no longer clear what they are talking about. Nic – More evidence as to whether you’re in a position to weigh in on what’s “nonsense”, Nic… From Willis’ greatest hits: > So I would consider 0.085% of the population dying to be a hard upper limit on what the disease does when you do nothing. No country to date has gotten there, and there is no sign that any country will get there after the virus subsides. https://judithcurry.com/2020/06/21/did-lockdowns-really-save-3-million-covid-19-deaths-as-flaxman-et-al-claim/#comment-919556 For the US, if we project from current numbers who have already died from COVID and add a projection of those that are currently infected and are likely to die…we will likely be at 0.12% at a minimum. Belgium is already at 0.17% And BTW, here’s what you said about Willis’ magical thinking… > the convergence in your graph of lines approaching the 0.085% of population deaths level is certainly suggestive of somewhere near that being a possible upper limit. I had forgotten that you speculated about Sweden topping out at 0.06%. They’re at 0.086% already. Looking at infections and ICU admission there now, (let’s conservatively say a minimum of 50 deaths per day for another month) and they’ll be at 0.1% before “peter[ING] out.” In fact, it’s not too unlikely that multiplying your speculated number by 200% will be much closer to the final number than what you anticipated. You might be better off if you paid more respect to Mr. Uncertainty. Oh. Forgot to mention, we’re already at more than 25 countries that have surpassed the population fatality rate that you and Willis speculated would be a “hard limit.” “No sign any county would get there” my a$$. How many will get there eventually, and even more to the point how many more would have gotten there absent vaccines despite your erroneous calculations about the effects of “herd immunity?” matthewrmarler \| January 2, 2021 at 12:53 pm \| Joshua: we’re already at more than 25 countries that have surpassed the population fatality rate that you and Willis speculated would be a “hard limit.” Nobody has written “admirably” accurate prognostications. Willis Eschenbach’s on that date have been more accurate than most (than any?) Deaths today in the US stand at 0.1% of the population at risk, much higher in some states than others. did-lockdowns-really-save-3-million-covid-19-deaths-as-flaxman-et-al-claim? No. Willis Eschenbach’s calculations are conclusive on that point. Confidence limits on the “hard limit” might have been a worthy addition to Willis Eschenbach’s essay, had we thought to calculate estimates of them. I had some thought about the uncertainty of estimating an upper bound, but I don’t think I wrote it, so I can’t take credit. The errors that other people made in no way makes Willis’ overconfidence pronouncements, based on magical thinking, and Nic’s co-signing onto those overconfident pronouncements, any wrong. > Confidence limits on the “hard limit” might have been a worthy addition to Willis Eschenbach’s essay, had we thought to calculate estimates of them. See, that’s the problem. Some people make magical-thinking, over-confident statements based on looking at lines on a graph. Other people do fundamental study and take the time to publish their work along with estimates of uncertainty. Of course those estimates of uncertainty could be wrong, but I think that formally estimating uncertainties is a better way to go. …any less wrong. matthewrmarler \| January 2, 2021 at 8:02 pm \| Reply Joshua, quoting Nic Lewis: > the convergence in your graph of lines approaching the 0.085% of population deaths level is certainly suggestive of somewhere near that being a possible upper limit. “Suggestive of somewhere near that” is certainly suggestive of uncertainty. Looking across the range of errors encountered by other forecasters, it is hard to deny that 0.2% is “somewhere near” 0.085%. But as I wrote elsewhere, it would have been better had we thought to compute a confidence interval for the upper limit. Meanwhile, San Diego County, CA has taken a turn for the worst since or coinciding with the most recent “lockdown”. https://www.sandiegouniontribune.com/tracking-coronavirus-cases-san-diego-county Follow links to other graphs to see the dramatic increase since about mid-Nov. Latest lockdown order was Dec 7, and if it made a difference that difference is not discernable in the graphs (or anywhere else in CA that I have seen so far.) > it is hard to deny that 0.2% is “somewhere near” 0.085%. In absolute terms, sure. In relative terms, based on where the numbers were when he made that projection, not so much. For example, IIRC, the number in Belgium was close to 0.85 at the time. I could dig back through and check because I commented on it at the time, but lets say it was as low as 0.07% at the time (it wasn’t, but we’ll go for that for the sake of argument). So Willis projected a growth of, say, 0.015% before the pandemic dies when actually in Belgium it grew by close to 0.1% or something like that. That’s quite substantial. And Nic signed on. The estimation may even be off by an order of magnitude by the time all is said and done. So that’s the most extreme example among countries of significant size. But by the time is over they will be off by a very significant % in a slew of countries. Perhaps 1/2 an order of magnitude in many. cerescokid \| January 2, 2021 at 8:20 pm \| https://www.latimes.com/projects/california-coronavirus-cases-tracking-outbreak/ While obviously still very high, there may be some hope of preliminary signs that the growth in case rate in Cali may be leveling out. Illness and deaths will still increase for weeks (because you can’t decouple positive tests from increased in hospitalizations, ICU admissions, and deaths) but maybe, hopefully flatten after that point. Unfortunately, there don’t seem to be signs of the same flattening out in the other largest states, New York, Florida, and Texas. Let’s hope that changes. Atomsk's Sanakan (@AtomsksSanakan) \| January 4, 2021 at 1:46 am \| Reply Re: “the convergence in your graph of lines approaching the 0.085% of population deaths level is certainly suggestive of somewhere near that being a possible upper limit.” Ludicrous. The population fatality rate (PFR) is an order of magnitude larger than that in a number of places, often going above 0.5%. This is another great example of why most climate “skeptics” should just be ignored on COVID-19. Their political ideology blinds them to reality, both on medical science and climate science. “The municipality of Castiglione d’Adda, a rural town of about 4550 inhabitants located South-East of Milan, has been heavily affected by SARS-CoV-2 infection […]. At the same time, 47 deaths were officially attributed to COVID-19.” Click to access 2020.06.24.20138875v2.full.pdf “During a four-month period, 1.6% of the entire adult population of Atahualpa, including 6.9% (27/392) of older adults, died from SARS-Cov-2-related causes.” https://www.sciencedirect.com/science/article/pii/S1201971220306305#bib0030 Note there are now 19 counties in the United States, home to over eighty thousand people, where 0.5% or more of the entire population has died from COVID. It's going to be very hard for the IFR to be "well below 0.5%"https://t.co/V9WS6DTi9J pic.twitter.com/4LsAg8iNCH — Gregory Travis (@greg_travis) January 1, 2021 [with: https://coronavirus.jhu.edu/us-map%5D Over 0.22% (103) of the population of Leticia (population – ~50k) in Amazonas state, Columbia have now died from clinically confirmed SARS-COV2 infection. >5% (2471) of the population has also been PCR diagnosed with SARS-COV-2 infection #COVID19 https://t.co/e8Xbb0NwbI pic.twitter.com/1HHh0tmujx — COVID Impact (@CovidSerology) September 12, 2020 Alan Lowey \| January 1, 2021 at 10:46 pm \| Reply My full respect to the UK health staff and frontline workers but the latest news is hinting at full lockdown until the end of the year, when vaccinations have finished being rolled out. A whole nother year (?) Interesting take from a credible source regarding more 1-shot vaccinations versus fewer 2-shot vaccinations. U.S. is now considering idea of a single vaccination shot, delaying shot #2 until months later. Last wk, I thought that was a bad idea – the trials that found 95% efficacy were 2 shots; why add extra complexity & a new curveball. But facts on the ground demand a rethink. (1/7) — Bob Wachter (@Bob_Wachter) December 31, 2020 Chebyshev \| January 2, 2021 at 2:10 am \| Reply It seems anywhere from 20-40% of health workers have refused to take the vaccine (or opted not to take it, if that sounds better). Is that a glitch in the matrix, Joshua? JMurphy \| January 2, 2021 at 9:18 am \| Do you have any links showing those figures? Joshua \| January 2, 2021 at 9:30 am \| Reply Cheby – There are many potential glitches. Perhaps the efficacy of vaccines will be eliminated in different virus variants. We may only be at the top of the 3rd or bottom of the 4th inning. But I wouldn’t be surprised that if the vaccines show benefit, people will get vaccinated at increasing rates. No reason to believe that %’s not getting it now will stay constant. Limited, not eliminated. Some good news for the UK: “Despite apocalyptic visions of traffic chaos at British ports, HGVs flowed freely to and from Dover and the Channel Tunnel today as the new UK-EU trading relationship was put to the test.” https://www.thetimes.co.uk/article/lorry-load-of-strawberries-is-first-casualty-of-brexit-xtq7dv59j JMurphy \| January 2, 2021 at 9:16 am \| Reply I’ve read that many hauliers are holding back, waiting to see how others cope with things, and lots of stockpiles were built up before the deadline so we’ll know more over the next week or two. Scotland hope to return to Europe soon! Alan Lowey \| January 2, 2021 at 10:18 am \| “so we’ll know more over the next week or two.” Yes, good point. climatereason \| January 2, 2021 at 12:19 pm \| Scotland have just been told it would take 10 years to join from date of first application. They could then join the whole host of minnows all scrambling for EU funds provided by a smaller pool of donors More confirmation that it’s health staff burn-out, working 11hrs/wk more and scared of catching covid themselves. It’s a terrible burden that has been placed upon them: voza0db \| January 2, 2021 at 2:56 pm \| Reply B.1.1.7 – the important part is that this is the final number the herd will remember from OPERATION COVIDIUS, since this one is clearly running out of gasoline! Richard Greene \| January 2, 2021 at 3:13 pm \| Reply Previous articles by Nic Lewis on COVID herd immunity were speculation, and it now appears his herd immunity beliefs were wrong. I wrote at the time it was too soon for his articles — in the middle of the pandemic. So I was not a fan when I started reading … but this article is well written, well documented, presents evidence clearly, and does not seem to jump to any conclusions. The final sentence may be the most important sentence in the article: “It is highly desirable that no SARS-CoV-2 or COVID-19 related report or study should hereafter be considered by the government or its advisers unless it is accompanied by a link at which all the data used is available.” Joe - the non epidemiologist \| January 2, 2021 at 3:52 pm \| Reply Regarding Nic’s early assessment of Herd Immunity / HI threshold, In 2-3 years, Most of what we believe is true at this point in time will be found to be wrong. One good thing in Nic’s assessment is that it is not governed by “Covid-freakout science. Lets wait until things shake out, and we can make a rational assessment before we claim someone was “Wrong” Richard Greene: So I was not a fan when I started reading … but this article is well written, well documented, presents evidence clearly, and does not seem to jump to any conclusions. I agree. I earlier questioned whether “herd immunity threshold” had any practical meaning. I found this essay better than the earlier ones. Franktoo \| January 3, 2021 at 5:46 am \| Reply Although I was initially skeptical that heterogeneity could reduce the HIT, I was surprise to have read about this possibility at Climate Etc a month or two before it was in the news section of Science and Nature. That’s pretty impressive company. And when I had enough time to digest the idea, it became clear to me that “gregarious people” are more likely to become immune earlier in a pandemic than “hermits”. In this sense, heterogeneity certainly exists and lowers the HIT. Unfortunately, no one knows how much it lowers the HIT. The problem with a heterogeneity parameter is that no one knows how big is should be. A large heterogeneity parameter illustrates the POTENTIAL importance of the phenomena. Other misleading information from early seropositivity studies and from Sweden added to the confusion. At the end of spring, several groups and the CDC wrongly concluded that there were between 6 and 15 missed cases of COVID for every one detected by PCR. That lead to a serious under-estimate of the IFR and the absurd idea COVID was no more deadly than influenza. It also suggested we could be much closer to herd immunity than Today, with 12.2% of the population of North Dakota having tested positive, we know that the number of undetected infections must be much lower, perhaps 1-2 undetected cases for every one we detect. After Nic’s first posts, I had been looking for any location where there have been two major surges. Surges in many Southern states occurred this summer, but not where they occurred in spring. Louisiana had a spring and summer surge, but they were in different counties. Was herd immunity preventing a second surge? Or was fear from an earlier surge causing people to be more cautious? It wasn’t until cases surged for a second time in France in late August, that it became clear that their first surge wasn’t ended by approaching herd immunity – unless the surges occurred in different regions of France. The first fall surges in the US were also in a new location, the north central states, and cumulative cases shot past all earlier records. In the past two months, it has finally become clear to me that surges are occurring in places that were hit hard this spring and summer. climatereason \| January 3, 2021 at 6:06 am \| Frasnk That is an interesting comment “And when I had enough time to digest the idea, it became clear to me that “gregarious people” are more likely to become immune earlier in a pandemic than “hermits” Our Northern cities in the UK were hit very hard by infections and I put that down to the far more gregarious nature of Northerners-especially the young-compared to Southerners. They like to mix and socialise far more than many of us in the south. > The problem with a heterogeneity parameter is that no one knows how big is should be. A large heterogeneity parameter illustrates the POTENTIAL importance of the phenomena. Other misleading information from early seropositivity studies and from Sweden added to the confusion. At the end of spring, several groups and the CDC wrongly concluded that there were between 6 and 15 missed cases of COVID for every one detected by PCR. Keep in mind that the case ascertainment rate has undoubtedly been increasing over time. I’m sure we’re capturing a higher % of true cases than we were in the beginning months when there was such a shortage of available testing and many times only the infectious (or even seriously ill) were being tested. > perhaps 1-2 undetected cases for every one we detect. We have to account for the long stretch when it was higher than it was when infections started spiking in the Dakotas Of course, in a theoretical sense, with the very first infection in the US, the pool of people to potentially get infected was reduced. In the vague way that proponents of this theory use the term, “herd immunity” had begun. But at what point guess the number of infected truly cause the rate is spread to be significantly, differentially slowed down? As opposed to the effect of NPIs? Or behavioral changes out of fear? Or wearing masks? It’s remarkable that to me that people like Nic are so confident they can accurately calculate that. We’ve hit 20 million tested positive in the US What factor do you want to use to calculate actual # of infections? 40%? 2X? 5X? 10X? Let’s say it’s 4X. 80 million people. Close to 25% of the population. It’s a staggering number. Do we see signs of slowing down? So you might answer “CASEDEMIC!.”. But the problem with that is that we are recording record numbers of deaths or at least relatively very high numbers of deaths day after day and it’s still rising. It will probably rise or stay high for another month at least. > perhaps 1-2 undetected cases for every one we detect Keep in mind, if it were 4 X undetected cases for every detected case (cumulatively), that’s 80 million people and that would mean the IFR is…. well, I’m not good at math, so I’ll let David Young figure that out. I mean it must be Ioannidis’ calculation of 0.03% is correct as David insists, right? I have wondered if ND might have come close to HIT in its surge. It had enough cumulative cases per capita that with a not crazy guess at missed cases, it could have been close enough that at immunity might have been a significant, if not the only factor in its downturn. Or, it might not have – I am just wondering, not asserting. The impact of immunity grows linearly with immunity. All else held equal Rt = R0(susceptible / total population). Sorry. Meant to say 0.3% for Ioannidis’ IFR and just 1 undetected case for every detected case, or 40 million. Anyway, geeze, I hope David comes round to calculate that for us. I suspect that the number of cases detected won’t just stop tomorrow, and I can’t calculate it myself but I think that at 40+ million cases, Ioannidis’ IFR calculation might turn out a tad low, but David kept insisting it was spot on! ” I had been looking for any location where there have been two major surges. ” Frank, I’ve been posting here about Arizona’s two surges – did you miss that. Our summer surge was so dramatic that it made headlines around the world. We are now in our winter surge and it is much higher. Check out 91-divoc for the curves. Our hospitals are in just as bad a shape as they were during the summer surge – so far. Oh, and the state just reported positive case counts for two days with significantly higher counts than any in our past – at 11,000+ cases each (the previous record was about 8500). Joshua \| January 3, 2021 at 11:58 am \| I was going to suggest that in Arizona, maybe while the # of cases spiked higher than earlier, maybe the deaths hadn’t. Then I looked. Not good Exactly. 91-divoc lets you plot deaths and cases on the same graph (different scales optional). It’s easy to see how well they do or don’t track. I would not be surprised if Arizona will face harsher control measures next week. Meanwhile, it is hazardous to get medical care, and my family members have some that cannot wait. I wish your family well. With care, probabilities are still in an individual’s favor, but it’s not getting better and the longer this stretches out, the more even good odds effectively dissipate. Mesocyclone and Josh: Thanks for pointing out Arizona to me, Meso. I’ve been focused on the Dakotas and surrounding territory, where the fall surge struck first and new cases are now way down. ND: 31 current cases per 100,000/day (about 20% of peak in mid-November). 12.2% cumulative detected infections – almost all in the fall when we can hope that the ratio of total cases to new cases was stable. There is no conclusive way to tell if this slowdown represents approaching herd immunity. AZ adds some new information. State-wide cumulative case are 7.9% of population (well below ND) and current surge hasn’t quite matched ND’s peak. However, the worst of the summer surge was localized in Yuma and Santa Cruz counties, where cumulative cases now total 13.6% of the population. AND where the pandemic clearly hasn’t subsided due to approaching herd immunity: 140 & 150 new cases per 100,000/day. This is the highest number of new cases/day I’ve seen combined with the highest number of cumulative cases – ie the best evidence that approaching herd immunity isn’t having an important impact when 13% of the population is known to be immune. That would be 26% or 39% immune if testing missed only one or two asymptomatic or mildly symptomatic cases for every case detected (reasonable lower and upper limits). And if detection was less efficient this summer, 13% cumulative cases in both ND and Yuma would represent somewhat higher estimated total immunity in Yuma (unless immunity weakens over six months). Rightly or wrongly, Nic has suggested that deaths are more reliable measure of the pandemic than detected cases (though deaths involve small numbers and associated noise in some places). If so, total deaths per 100,000 in ND (175) have effectively caught up with the long time leaders NJ/NY/MA from the spring surge (about 200). Cumulative detected cases amount to only 5-6% of population in these three state. If deaths were the true measure of total infections, then we missed about twice as many cases in NY/NJ/MA per detected case this spring as we did in ND this fall. Of course, there are two big problems comparing cases with deaths: improving treatment and falling age of the average person infected. Both suggest that missing twice as many cases earlier in the pandemic is likely somewhat too high. The good news is that surges so far have only lasted only a month or two. I predict that AZ will be under 40-50 new cases/day/100,000 by February 1. Belgium is the most extreme example reaching 160 new cases/day per 100,000 two months ago, but remaining above 80 for only 20 days and above 40 for only 37 days. It seems to me that surges are always suppressed by public health measures implemented for fear of overflowing hospitals or by people’s fear when they recognize there may not be a hospital bed available if they get sick. And the more severe the surge, the shorter it seems to last. Every US state has take different paths at different times, but cumulative cases amount to 8+/-4% across all but a few states. “The good news is that surges so far have only lasted only a month or two. I predict that AZ will be under 40-50 new cases/day/100,000 by February 1. ” Thanks for your analysis re: herd immunity. As an Arizona resident, I sure hope you’re right that the surge will drop. I am not seeing many signs that people are becoming less careless. And, some schools are still open. Meanwhile, we just have to hope that we don’t need medical care – but… a person close to me needs surgery that cannot wait until February. Sooner or later something will have to give. The Catholic Diocese of Tucson, for example, just banned almost all in-person masses. If their past policies have matched that of the Phoenix Diocese, then they were already taking pretty good precautions – 25% capacity at mass, mandatory masks, etc. I think that Santa Cruz and Yuma counties aren’t very good places to draw conclusions from, because they have so many cases being imported from across the border, plus they have a low population. mesocyclone: “The impact of immunity grows linearly with immunity. All else held equal Rt = R0(susceptible / total population).” That is only true in the case of a homogeneous population. Where there is heterogeneity in susceptibility then the immunity factor lambda (which depends also on how strongly variability in susceptibility is correlated with variability in infectivity, via people’s social connectivity) comes in. The relationship then is: Rt = R0 * (susceptible / total population)^lambda. See Tkachenko et al. Eq.[15]. They estimate that lambda = ~4. https://doi.org/10.1101/2020.07.26.20162420 Robert Clark \| January 2, 2021 at 7:18 pm \| Reply date isolated increase % total tests 12/16/2020 213,811 39,522 22.7 1,789,897 12/17/2020 191,082 22,729 -10.6 1,730,046 12/18/2020 208,870 17,788 9.3 2,218,532 12/19/2020 172,190 -36,680 -17.6 1,959,160 12/20/2020 175,328 3,138 1.8 1,784,786 12/21/2020 174,073 -1,255 -0.7 2,115,141 12/24/2020 171,423 -32,044 15.7 1,724,348 12/25/2020 97,800 -73,623 -42.9 1,365,808 12/30/2020 209,077 39,101 23.2 877,253 1/1/2021 160,801 -39,354 -19.6 1,320,033 1/2/2021 202,652 41,852 26 1,818,100 202,652 is 11.1% of total tests. Had to move. Stayed to long there. Things should be back to normal by Tuesday. The holidays are over. 1/3/2021 187,038 -15,614 -7.7 1,541,675 154,807 is 9.3% of total tests. 1/5/2021 215,456 60,649 39.2 2,039,242 Hopefully all are back to work. They have all the numbers up to date. We will see where things go from here. 1/6/2021 231,800 16,314 7.6 1,574,773 Today was not for the Republic’s best. 220,634 is 12% of total tests. All should be back to work and numbers caught up. It appears they may still be updating. Tomorriw is another day. Robert Clark \| January 10, 2021 at 7:19 pm \| Reply 1/10/2021 264,265 45,268 20.7 1,981,459 1/11/2021 187,052 -77,213 -29.2 1,925,416 1/11/2021 196,971 9,919 5.3 2,101,922 1/13/2021 208,180 11,209 5.7 1,837,552 1/14/2021 193,849 -14,331 6.9 2,015,420 Back in June you brought the daily positives down to 20,000. We figured out that it remained there because that was what the virus made in the first 4 days before the test could detect it. I believe we are at that point again. The asymptomatic are making an average of 2,000,000 positive daily. It will probably stay here until the vaccine begins lowering the asymptomatic.. Hopefully it has begun. 1/16/2021 194,581 -21,146 -9.8 2,674,952 Total % down 22.5%. Total tests up 14.8% Those numbers do not make sense. The new President has not taken the oath yet. 1/18/2021 129,790 _-36,678 -22 2,095,254 If there are any of you reading this (which I doubt) you are finally seeing the results of your work. Your job was to find the infected. The contact tracers tracers used your findings and above is the results. Just for me ,if you are there, a 3 word reply. mesocyclone \| January 18, 2021 at 8:07 pm \| How about explaining what this is. I got a bunch of emails of your comments, witnb no idea what these columns mean. Robert Clark \| January 19, 2021 at 6:29 pm \| This is me following the virus. I started in March and we just Began lowering the daily growth. 1/18/2021 129,790 -36,678 -22 2,095,254 nickreality65 \| January 3, 2021 at 6:33 pm \| Reply Between 12/9/20 and 12/23/20 CDC logged 30,227 deaths attributed to C-19. There were 148,206 deaths due to all causes. The 65+ demographic was accountable for 85% of those C-19 deaths. 85.6% of C-19 CASES are among those UNDER 65 years of age. (CDC) 80.7% of C-19 DEATHS are among those OVER 65 years of age. (16% of population) 24.8% of C-19 deaths occurred in nursing homes and hospice care. Over half of the CASES never see a doctor, hospital or morgue. If you are 65+ w multiple health issues in a crowded nursing home and the staff brings in C-19 you are screwed, but then you were screwed anyway. In other words: If you are already seriously ill, C-19 will probably finish you off, i.e. no different from the seasonal flu or pneumonia C-19 is not a problem for the young and healthy herd. Mother Nature and her buddy Grim Reaper are just doing their jobs, culling the herd of the too many, too old, too sick warehoused too close together as Medicare/Medicaid cash cows in poorly run contagious lethal elder care facilities. Japan has the highest percentage of 65+, 27%, yet still under 4,000 deaths. (WHO) What do they know/do the rest of the world does not? If C-19 is mostly killing off old sick people why are our elected morons suspending civil liberties, due process, bankrupting the country with lockdowns, distancing and masked clown shows? Guess they can’t impose the NWO Grand Reset with actual facts. And the lying, fact free, fake news MSM left-wing propaganda coup machine has betrayed its responsibility to democracy and an informed public. mesocyclone \| January 4, 2021 at 2:15 pm \| Reply Most who die are not seriously ill. They may have dangerous conditions, but they are not acutely dying of them. And, most would not die from the seasonal flu. To assert otherwise is to ignore the massive increase in all-cause deaths under COVID – in many countries. The average COVID19 death results in a 10 year loss of life, compared to no COVID19. Furthermore, many of the vulnerable are not in elder care facilities, and many are working or living with those who need to work. But in any case, your argument is remarkably sociopathic. Yeah, let’s just let Mother Nature cull the herd. I am disgusted. Nickrealty comment – “In other words: If you are already seriously ill, C-19 will probably finish you off, i.e. no different from the seasonal flu or pneumonia” Meso’s response – “Most who die are not seriously ill. They may have dangerous conditions, but they are not acutely dying of them.” both comments are partly correct. The most recent stats that I could locate was from 2012-2013, which indicated the median (not average) life expectancy for a male entering a nursing home was 3-4 months and the median life expectancy for female was 7 months. I couldnt find the median life expectancy for 2018-2019 though the average jumped to approx 24 months from an average life expectancy of approx 15 months in the 2012 time frame. Basically, a third to half of the individuals who enter a nursing home go there to die. From that standpoint, Nick’s comment is correct. On the other hand, one half or more are in LTC for the assisted living aspect which makes Meso’s comment correct. Unfortunately, the data for who dies in nursing homes from covid or with covid is lumped into the broader category of Long term care, which makes distinquishing the difference impractical. “On the other hand, one half or more are in LTC for the assisted living aspect which makes Meso’s comment correct. ” Thanks, but you missed an important group – the large number of elderly who are not in LTC at all. That doesn’t mean they don’t have comorbidities, it just means they don’t need to be in a facility. I know far more in the risk category who live outside LTC than who live inside. dpy6629 \| January 10, 2021 at 7:36 pm \| It’s anecdotal but my brother reports that the typical covid death in his system is a very obese person in their 70s or 80s. Being very obese is a life threatening condition because you almost certainly have high blood pressure, diabetes, and often quite high blood lipids. This makes you much more likely to have a heart attack just to name one thing. I’ve been doing extensive research on this topic in my quest to improve my insulin sensitivity and most people don’t realize how powerful large weight losses are for arresting these metabolic disorders. One reason why US death rates are so high is probably because America is in the throes of an obesity and diabetes epidemic. Swedes on the other hand have much lower obesity rates. In short, these so called “non serious” comorbidities are in fact very serious and often life threatening on their own. They are also quite common among the elderly in the US. Joshua \| January 10, 2021 at 8:10 pm \| > Swedes on the other hand have much lower obesity rates. US PFR = 0.12%, Sweden = 0.092% Considering how Sweden should be way better at controlling for COVID reality for many reasons, the relative prevalence of obesity in the two countries seems unlikely to be a terribly explantory variable. Josh, you doubt most true statements. You have no evidence. Mine is very reliable although anecdotal. UK-Weather Lass \| January 4, 2021 at 4:42 am \| Reply It is a good news day in the UK with the first Astra Zeneka vaccination. However, that is totally shafted by Government threats of more extreme restrictions driven, I assume, by the continued ability of the variant SARS-CoV-2, known about since early autumn, to confound all attempt to suppress it via more stringent restrictions. How extreme can you make restrictions before the penny drops and it is realised that something we are doing isn’t working the way it was envisioned by expert scientists and lay politicians? Does the answer lie in the fact that in spite of having had almost a year to ratchet up resources in our NHS nothing has been done by Government to do so, and our ‘famed’ Nightingale Hospitals are no longer regarded as potential spare hospital capacity but instead are now possible potential mass vaccination sites. Rather than blame people for not spacing, facing, and washing, how about asking serious questions of Government ministers and their experts who are failing to make good choices of policy with effective outcomes. Out testing regime is poor (too little expertise). Out tracing regime is poor (too little experience). The data emerging from these will therefore be unreliable to say the least (made up as they go along). Why are the genuine criticisms of these facts being ignored by those in charge and when is this going to be tackled by all our media and the people who have had their livelihoods unnecessarily destroyed given some hope for the future? David Wojick \| January 4, 2021 at 2:27 pm \| Reply Regarding the $542/kWh 232 kWh powerwall, there is also the cost of hooking and running millions of them together and housing them. EIA reports that even the tiny 50 MWh utility scale battery systems we are building today average around $1500/kWh. New York City would need over 3 million MWh or 12 million powerwalls working together. The scale is staggering!. Tesla has built a few systems for $500/kWh but I think these must be loss leaders. Tesla can afford to sell a bunch for a fraction of cost in order to become the market leader. Chebyshev \| January 4, 2021 at 6:56 pm \| Reply This was Australia during SARS, which was a far deadlier than COVID19. You would have been fined for being “sciency” on masks! Retailers who cash in on community fears about SARS by exaggerating the health benefits of surgical masks could face fines of up to $110,000. NSW Fair Trading Minister Reba Meagher yesterday warned that distributors and traders could be prosecuted if it was suggested the masks offered unrealistic levels of protection from the disease. “I’m sure everyone would agree that it is un-Australian to profiteer from people’s fears and anxieties,” Ms Meagher said. “There appears to be some debate about whether surgical masks are able to minimise the effects of SARS.” Ms Meagher said her department would investigate any complaints about false mask claims which concerned the public. https://amp.smh.com.au/national/farce-mask-its-safe-for-only-20-minutes-20030427-gdgnyo.html News bulletin: Things change. You should be glad that they do. Balaji \| January 4, 2021 at 10:19 pm \| Joshua – Really? Are masks on the frontier of scientific research? That’s news to me. Balaji – > Are masks on the frontier of scientific research? Good point. ‘Cause that’s EXACTLY what I said. Franktoo \| January 5, 2021 at 10:04 pm \| Reply Chebysky and Bali: Masks and other PPE have been used to protect doctors and nurses from COVID and other respiratory illnesses in hospitals. Much research has been done. There is no doubt their PPE works. Unfortunately we don’t have the capability of providing that level of protection to ordinary citizens. Until COVID came along, there wasn’t much of a need to protect the public from respiratory viruses using masks. Studies with volunteers wearing surgical masks to prevent influenza on college campuses and in homes showed that masks provided significant protect to those who wore them, but fear of influenza didn’t provide much motivation to wear them. In public health, compliance is as important as efficacy. (A drug whose side effects cause most patients to stop taking it is as worthless as a drug with no efficacy.) If ordinary citizens weren’t being misled by conspiracy theorists like you, fear of COVID and the damage it is doing to our economy and lifestyle should provide an appropriate incentive to wear masks. The efficacy of masks is complicated by the fact that there are two major modes of transmission of COVID: a) droplets that are sprayed by coughing, talking, etc. and b) aerosols that can remain can remain suspended and infectious in the air for hours. Cigarette smoke is an aerosol and if you can smell someone’s smoke, they can infect you. (Unfortunately, the smell of cigarettes is deposited on surfaces where it lingers longer than the aerosols.) Almost any mask will block droplets. Aerosols pass through ordinary cloth masks fairly easily unless they contain a blown polypropylene layer like surgical masks. This is why: Some people may be misled into thinking that masks will provide 100% protection and be encouraged to engage in risky behavior. The other problem is that the N95 masks that are used in hospitals are held tightly to the face by powerful elastic bands and are carefully checked for fit by professionals. The masks worn by the public allow aerosols to leak around the edges and through the fabric to various extents depending on fit. You can buy masks made out of materials with a better PFE (particle filtration efficiency), but between leakage, deterioration with use and washing, it isn’t clear that ordinary people can cut their risk of infection or transmission by aerosols by much more than 50%. So the authorities are focusing on getting people to wear any kind of mask and block transmissions by droplets (by consensus the major route of transmission) and ignoring the far more challenging problem of getting people to use masks that are more effective against aerosols. Universal use of cloth masks in theory should cut transmission by at least 50%, which would be enough to end to end the pandemic in most countries. Since every surge we have seen so far – including those in North Dakota and Belgium where 1% of the populations was testing positive every week – appears to have ended well short of herd immunity, we know that something has caused surges to end. Perhaps when hospitals are overflowing, people are finally motivated enough to wear masks. Chebyshev \| January 4, 2021 at 10:24 pm \| Reply Biden’s miracle rescue plan is underway … https://www.zerohedge.com/covid-19/fda-admits-pcr-tests-give-false-results-prepares-ground-biden-virus-rescue-miracle This article is mostly bad joke by conspiracy theorists designed to reduce public trust in the scientific experts we need to fight this pandemic – the same scientific experts who have created vaccines with the potential to end this pandemic. Some particulars: PCR assays are NOT intended to prove who is and who isn’t infectious. Assays needed to determine the presence of infectious virus must be run special laboratories and are totally unsuitable for mass testing. PCR assays detect the presence of full-length OR fragmented viral nucleic acids. The number of cycles of amplification needed to produce a detectable signal provides a rough estimate of how much viral nucleic acid (“viral load” or “viral titer”) was present in a patient’s sample. A small viral load could mean that someone was infected three days ago and is not yet infectious, but WILL BE INFECTIOUS in a day or two – and it takes a few days to get results back. It is well known that viral nucleic acids (probably mostly fragmented) can be detected for many days after a person is no longer considered to be infectious. The CDC’s current guidelines for patients and health care workers returning to normal activity after a positive test are based on disappearance of symptoms in symptomatic patients and time in asymptomatic patients. They don’t require a negative PCR test. The first link in the first sentence about FALSE RESULTS refers to mistakes personnel make in collecting samples from patients, not to false results from the PCR assay itself. Contamination of patient samples with the target nucleic acids in the laboratory is a well known problem with PCR assays, especially when many cycles of amplification are run. Every assay includes positive and negative controls intended to detect systematic contamination and other problems. Although no assay is 100% reliable, PCR assays are highly reproducible. This nonsense about “false positive” is false. And not remotely positive. You really ought to stop spreading nonsense. It isn’t good for anyone when you do that: >> And we can see this incredible accuracy happening in real life. In Australia, despite hundreds of thousands of tests conducted every week, there are vanishingly few positive results. In New South Wales, the state that I live in, we conduct more than 115,000 tests every week with <40 positive results. Even if every one of those were a false positive, the false positive rate would still be less than a fraction of 0.1%. https://gidmk.medium.com/most-positive-coronavirus-tests-are-true-positives-60c95fe54fec UK new covid variant detected in New York and Western Australia. UK in full lockdown until vaccinations rolled out, which is 3-4 months minimum. France has a potential big problem in that vaccinations are at a snail’s pace due to the people having the right to refuse the jab. I predict France will be forced to abandon the lockdown-til-vacination strategy and open up the economy with those at high risk taking their own precautions. The World Health Organisation changed it’s official definition of ‘herd immunity’ on 13th Nov 2020 so that it only refers to mass vaccination. Natural immunisation was omitted which had been previously been included in their definition from June 2020. John Murphy \| January 6, 2021 at 7:28 am \| Reply Do you have any information about that “lockdown-til-vaccination strategy”? I thought only restaurants, bars, etc. were closed but everything else, including schools, still open. They have a curfew from 6/8pm but, generally, seem to be less restrictive than the UK. Alan Lowey \| January 6, 2021 at 9:56 am \| I was projecting into the future assuming they get a more infectious variant as well. Incidentally, Sky News Australia was reporting in the US that 60% of carehome workers didn’t want to take the vaccination jab. It could be the same outcome there. JMurphy \| January 6, 2021 at 2:18 pm \| “…Sky News Australia was reporting in the US that 60% of carehome workers didn’t want to take the vaccination jab” I saw that figure for Ohio, not America as a whole. Do you have more info? https://www.businessinsider.com/nursing-home-staff-ohio-refusing-covid-vaccine-dewine-2020-12?r=US&IR=T Here is none other than NYT discussing about manufacturing fake epidemics using fast unreliable tests like PCR: The morbidity and mortality we’re seeing goes in parallel with the # of positive tests. The PCR test is not the right test for surveillance, but this isn’t some kind of pandemic that isn’t. This meme that it’s a “casedemic” is false. The “false positives” meme is false. You really out to stop with this nonsense. It's highly irresponsible. Chebyshev \| January 5, 2021 at 9:56 pm \| Joshua – I have lived in and worked in NSW for a while. Miss the beaches :) This ought to be the case for ANY disease. I don’t see how this is a special insight. The point is that governments, PH bureaucracies and media have switched their bleating from death to hospital overrun to cases and it appears that the idea is to keep the deadly pandemic narrative alive in anyway possible. With less than 40 positive tests and even less deaths, why do you Australians still market this as a pandemic? > This ought to be the case for ANY disease. I don’t see how this is a special insight. Why are you expecting special insight? If course it isn’t “special insight.” It’s common sense. That was my point. > The point is that governments, PH bureaucracies and media have switched their bleating from death to hospital overrun to cases… You’re acting as if they can be decoupled. They can’t. That’s the point. >With less than 40 positive tests and even less deaths, why do you Australians still market this as a pandemic? I’m not Australian. I gave you the link. Read it. No one is “marketing” a pandemic. Don’t be paranoid. Joshua: Here are some possible answers to questions you have raised: CFR = deaths/detected case. IFR = deaths/total cases. CRF/IFR = total cases/detected cases. total cases = seropositive Seropositivity surveys this spring suggested that we were missing about 10 cases for every for case we detected by PCR and CFR/IFR = 11. Now that cumulative detected cases have reached 14% of the total populations in some areas (and up to 20% in smaller locations that might be atypical, say with a prison), it is obvious that the early seropositivity surveys must have been wrong – possibly because of a higher false positive rate in the field than was established in the laboratory. This caused early workers to calculate an IFR similar to influenza and make the assertion that coronavirus was no more deadly than seasonal influenza. However, influenza kills a significant number of people only in the winter. We are now seeing just how deadly coronavirus can be in the winter – despite our best efforts to suppress it (that we never made for seasonal influenza). That deadliness is a function of both increased transmissibility and increased lethality per infection. Clearly we got a great deal wrong early in the pandemic. North Dakota today has 12+% cumulative infections (almost all this fall) and a death rate of 178/100,000, very close to that of NY, NJ, and MA before they began surging in the past month. However cumulative cases are only 5.5% in these three states. Therefore; CFR_spring = 2CFR_fall If the IFR rate had remained constant, then: (CRF/IFR)_spring = 2(CRF/IFR)_fall (total cases/det cases)_spring = 2(total cases/det cases)_fall However, improved treatments and the falling age of those infected (as the vulnerable learned to protect themselves) means that: IFR_spring = XIFR_fall (total cases/det cases)_spring = (2/X)(total cases/det cases)_fall where X is a number greater than 1 that reflects the decreasing IFR due to better treatment. Therefore the ratio of total cases to detected cases has changed by less than a factor of 2. So, while we may want to assume that increased testing capacity has dramatically changed the factor that converts detected cases into total cases, this just isn’t true. In Yuma and Santa Cruz counties in AZ, 14.3% of the population has tested positive and the new cases are being detect at a near record rate 150-170 new cases/100,000/day = 0.15%-0.17% of population/day or 1+%/week. Clearly approaching herd immunity doesn’t appear to be playing a major role limiting the pandemic at the moment. If we think approaching herd immunity must slow the pandemic when 50% (?) of the people are immune, then we could be missing 2 cases (but probably not 3 cases) for every 1 we detect and still have a raging pandemic. And since we know there are asymptomatic infections and mildly symptomatic infections that never get tested, it would be surprising if we there were much less than 1 (?) undetected case for every detected case. Substitute your own estimates for the ?’s. So CFR/IFR is likely 2-3. More unnecessary alarmism from conspiracy theorist Chebyshev. From the scientific article on this “false epidemic”. The idiots at the NYT didn’t report the whole story. In a previous study, environmental contamination from whole cell pertussis vaccines was found to be the cause of positive PCR results from patient specimens.7 Environmental investigation was performed in rooms at 2 different clinics where the vaccine was administered to the patients. B. pertussis PCR-positive material was detected on laboratory benches, steel tables, staff’s clothes, and skin of the hands of the staff in the vaccination room at both clinics. In the clinic where the vaccine administration and specimen collection for B. pertussis were separated by a great distance, patient specimens were culture negative and PCR-negative. However, in the clinic where the vaccinations were performed in closer proximity to the examination room, 91% of the patient specimens were PCR-positive and 66% of the specimens were culture-negative. In this situation, the whole cell pertussis vaccine was the cause of the contamination. The presence of DNA in whole cell vaccines is predictable. Depending on the method of antigen preparation in the acellular pertussis vaccines, the presence of residual DNA might also be predictable. https://journals.lww.com/pidj/FullText/2008/01000/Real_Time_Polymerase_Chain_Reaction_Detection_of.17.aspx In the absence of politicization, science is usually a self-correcting endeavor, though detecting and correcting problems can sometimes be challenging. (The existence of the IPCC, a political organization not run on scientific principles, makes climate science an exception to this generalization.) The fact that information from mistakes like this one is published and widely distributed is why the possibility that COVID mRNA vaccines could contaminate PCR and antibody assays has undoubtably been considered. This is one reason that the FDA reviews data real labs trying out new tests before they license them for sale. https://www.turnto23.com/news/coronavirus/doctor-covid-vaccine-wont-cause-false-positive-results What isn’t self-correcting are conspiracy theories spread by social media. There is a pandemic of conspiracy theories that – in the long run – could cause far more damage than COVID. Extremists on both sides are destroying public confidence in our police (BLM), historical heritage (1619 Project), FBI, elections, rule of law, etc. Science magazine has a useful review on increased transmissibility of some variants. https://science.sciencemag.org/content/371/6524/9?utm_source=Nature+Briefing&utm_campaign=bc64e831c1-briefing-dy-20210104&utm_medium=email&utm_term=0_c9dfd39373-bc64e831c1-43368041 The spike protein in some variants is predicted to bind more tightly to the ACE receptor. However, affinity for the ACE receptor is unimportant if bound virus is internalized faster than it dissociates from the ACE receptor. The rate at which the virus reaches an ACE receptor is controlled by diffusion, which is the same for all variants. There is an on-rate for binding to the receptor and an off-rate for dissociation from the receptor and affinity is the ratio of the on- and off-rate constants. The article says: “Gupta also engineered a lentivirus to express mutated versions of SARS-CoV-2’s spike and found that the [69-70] deletion alone made the virus twice as infectious for human cells.” Here is a functional assay unambiguously demonstrating the importance of a particular mutation. Unfortunately, epidemiological data never involves variants with single mutations. “Yet exactly what impact each mutation has is much more difficult to assess than spotting them or showing they’re on the rise, says Seema Lakdawala, a biologist at the University of Pittsburgh.” “Animal experiments can help show an effect, but they have limitations. Hamsters already transmit SARS-CoV-2 virus rapidly, for instance, which could obscure any effect of the new variant. Ferrets transmit it less efficiently, so a difference may be more easily detectable, Lakdawala says. “But does that really translate to humans? I doubt it.” A definitive answer may be months off, she predicts.” Chemists are taught that the rate-limiting step in a series of reactions controls the rate of product formation. If the rate limiting step is gains entry to a human cell, then mutations effecting all later steps should be irrelevant. If the rate of replication of viral RNA is limiting, then mutations in both the rate of entry and the rate of replication could be important. Natural selection of fitter viruses can only occur by mutations that control the rate-limiting step. Paranoid? Not at all. I have my cloth mask, which, according to the new advances in mask science as you highlighted, saves me from not only COVID19 but an assortment of similar or larger sized viruses. I feel like a superman. Joshua \| January 5, 2021 at 11:53 pm \| Reply > I have my cloth mask, which, according to the new advances in mask science as you highlighted, saves me from not only COVID19… You should start paying attention. The benefit from you wearing a mask is primarily to protect others from you if you’re infectious. It isn’t all about you, Cheby. Chebyshev \| January 6, 2021 at 12:09 am \| Oh yes. Just like a Superman saves others! I like how you threw in “primarily” there. Try paying attention. It isn’t about “saving” others. It’s about reducing the chances of you infecting others if you’re infectious. Yes, that is the primary reason for you to wear a mask. Primary. Glad you noticed that. So, under your regime, everyone seems to be presumed sick (ie universal mask mandates). Is that a matter of convenience, lazy problem solving or there is some advanced science behind it? It also follows, under your regime, that you would be wearing mask all the time for the rest of your life? Who knows you could be sick at any given time? After all it is about others, ain’t it? Please bear with my limited reasoning capabilities. Most appreciated. Humbly yours, Chebyshev. China bans WHO team of experts to investigate source of covid-19, just a week before their departure. Suspicions of foul play only increase: rtj1211 \| January 6, 2021 at 9:33 am \| Reply The whole arguments about ‘infectivity’ really are incredibly ridiculous. Here are the basics of reality: 1. For 99%+ of the population, becoming infected is a good thing: the body’s natural immune system will become activated and resistance will ensue until such time as a virus mutates sufficiently to warrant a new immune response being required. 2. For the elderly, the immunocompromised and otherwise generally seriously unhealthy, the greater infectivity is a problem if the virulence is equal or greater to the initial strain.The evidence of previous epidemics the past 100 years is that in general, viruses mutate to become more infectious but LESS virulent as a strategy for viral replication. Nonetheless there is a justification in immunising such folks or asking the immunocompromised to take greater steps to prevent contact with healthy infected individuals. 3. As it is, the only important data for governmental decisions are the excess number of deaths as compared to the 5-yearly means. The UK data for England and Wales is published by the Office for National Statistics on a weekly basis where registered deaths are concerned. The evidence is absolutely categorical that no crisis akin to the period of April 2020 has occurred since October the 1st in the UK, with the peak of excess deaths in late November 2020 representing a 20.8% excess death rate, with the latest figures of December 18th being 12.7% above average. Such an excess is entirely within normal variability and correlates with a cooler early December 2020 than in recent years (nothing excessive, mind you). Such data conclusively shows that either the UK government is dangerously incompetent and in need of removal from office; or they are willfully corrupt and malevolent, wasting literally tens of billions of pounds on futile track n trace + inadequately tested vaccines, whilst simultaneously torching the SME business ecosystem which employs upward of 10 million people in the UK. Not to put too fine a point on it, the opinions of Professors Neil Ferguson, Peter Horby should be discounted. The employment of Chris Whitty and Patrick Vallance should be terminated. And the Queen should dissolve Parliament to remove the completely corrupt and incompetent Government of Boris Johnson (we won’t go into the totally corrupt ‘procurement’ procedures seen for billions of pounds of UK Govt spending in 2020 which would shame a banana republic run by Bernie Madoff…) et al. rtj1211 – I always love it when I get to meet the smartest person in the room. > 1. For 99%+ of the population, becoming infected is a good thing: the body’s natural immune system will become activated and resistance will ensue until such time as a virus mutates sufficiently to warrant a new immune response being required. A good thing as compared to what? While the number of people below 85, or 75, or even 65 who die from COVID is fairly low, the number of people who get significantly ill is much greater and even further, the number of people hospitalized is much greater. That isn’t a “good thing” in an absolute sense, but in a relative sense it’s obviously far less of a “good thing” than if they don’t get infected and we can establish “herd immunity” primarily through vaccination. >2. For the elderly, the immunocompromised and otherwise generally seriously unhealthy, the greater infectivity is a problem if the virulence is equal or greater to the initial strain.The evidence of previous epidemics the past 100 years is that in general, viruses mutate to become more infectious but LESS virulent as a strategy for viral replication. If you followed the discussion of this among people who actually study the related science – you will see that mostly all of them reject your assumption there. If you need it, I could dig out some links for you. But maybe yu should just try actually researching the issue? > 3. As it is, the only important data for governmental decisions are the excess number of deaths as compared to the 5-yearly means. Excess deaths is not a very good metric to use, as there are a lot of confounding factors. > The UK data for England and Wales is published by the Office for National Statistics on a weekly basis where registered deaths are concerned. The evidence is absolutely categorical that no crisis akin to the period of April 2020 has occurred since October the 1st in the UK, Once again, you shouldn’t be making statements such as that unless you have control for confounding factors (such as fewer deaths from the flu or other causes when people significantly reduce their activity levels). Perhaps you have it? In which case, please do let us know how you’re control for the confounding factors. > Such data conclusively shows that either the UK government is dangerously incompetent and in need of removal from office; or they are willfully corrupt and malevolent, wasting literally tens of billions of pounds on futile track n trace + inadequately tested vaccines, whilst simultaneously torching the SME business ecosystem which employs upward of 10 million people in the UK. Arguing from incredulity is a fallacy. > The UK data … > Such data conclusively shows … EU member states has growing tensions over slow rollout of vaccinations. The UK is lucky to be out of the debacle: Brace yourselves for another worldwide pandemic with a 60% mortality rate in humans: Potential big problems ahead with vaccines not effective against new variant strains in UK: “However, transport minister Grant Shapps said there were fears that some vaccines might not work properly against a highly contagious variant of the coronavirus that has emerged in South Africa. “This is a very big concern for the scientists,” he told LBC radio. A laboratory study by the U.S. drugmaker Pfizer, not yet peer-reviewed, indicated that the vaccine it is making, developed by Germany’s BioNTech, does work against one key mutation in the new variants found in Britain and South Africa.” https://www.reuters.com/article/uk-health-coronavirus-britain/uk-minister-says-vaccine-might-not-work-against-safrican-variant-idUSKBN29D0S2 Apparently Pfizer vaccines does* work against new UK strain: South African strain found in Australia under quarantine, reported to have 90% increase in transmissability: Third vaccine approval in UK pushes ahead with rapid rollout. There’s still hope that vaccination programme will succeed in coming months: Atomsk's Sanakan (@AtomsksSanakan) \| January 8, 2021 at 2:40 pm \| Reply Nic Lewis said this on August 17: “I likewise concluded that NYC reached herd immunity in April. I think London and Stockholm have also done so, and no doubt various other major cities as well. I view Stockholm as an important case study, since it never had a lockdown and behaviour now seems not to be too far off normal. The same goes for Geneva, save that it did have a lockdown originally.” https://www.nicholaslewis.org/why-herd-immunity-to-covid-19-is-reached-much-earlier-than-thought-update/ https://judithcurry.com/2020/06/28/the-progress-of-the-covid-19-epidemic-in-sweden-an-analysis/ As I and others have explained for months now, herd immunity is about non-mitigated baseline conditions of R0; i.e. no additional public health interventions and no additional behavior changes beyond what would have been present at about the same time of the year in 2019. So if those 5 regions above really reached the herd immunity threshold in March/April 2020, then immunity should be sufficient to keep R less than 1 in non-mitigated baseline conditions, let alone under the mitigated non-baseline situations that actually existed in those regions. So after April, no 2nd wave with no increase in cases/day: A plea: if you're going to show data to argue for herd immnuity, show case data. There's not some fixed number of deaths or hospitalizations that gets you to herd immunity. And it doesn't matter if deaths are decreasing; if cases are increasing you aren't close to herd immunity. — Carl T. Bergstrom (@CT_Bergstrom) August 15, 2020 In reality, all 5 region had 2nd waves with increases in SARS-CoV-2 cases/day and COVID-19 deaths/day. In fact, Geneva’s 2nd wave in November wave was worse in terms of deaths/day than their 1st wave, let alone in terms of cases/day: Geneva: https://www.covid19.admin.ch/en/epidemiologic/death?detRel=abs&detTime=total&detGeo=GE https://ourworldindata.org/coronavirus-data-explorer?zoomToSelection=true&time=earliest..latest&country=SWE~DNK~FIN~NOR~ISL&region=World&casesMetric=true&interval=smoothed&perCapita=true&smoothing=7&pickerMetric=location&pickerSort=asc Stockholm, Sweden: https://experience.arcgis.com/experience/19fc7e3f61ec4e86af178fe2275029c5/page/page_0/ https://coronavirus.data.gov.uk/details/cases?areaType=region&areaName=London https://www1.nyc.gov/site/doh/covid/covid-19-data-trends.page#epicurve The “HIT is low” idea is thus deader than dead. Anyone still advocating it is either willfully ignorant, disingenuous, and/or ideologically-motivated to the point of crippling bias. Alan Lowey \| January 10, 2021 at 10:34 am \| Reply Ivermectin as a well known super drug can be used to combat covid-19 but ignored by health authorities and WHO etc. rtj1211 \| January 19, 2021 at 10:06 am \| Reply The real question to be asked is quite simple: ‘what story line could the Establishment come up with to scare the uneducated population again? What is absolutely clear to anyone with an independent mind is that lockdown and economic catastrophe was the absolute alpha and omega of the billionaire elite. Bill Gates smirking back in spring 2020 about ‘people won’t laugh when a worse variant emerges’ gave the game away long ago. The variant isn’t worse, but it can be PORTAYED as worse, simply because it is NEW and UNCHARACTERISED. That justifies lockdowns on steroids by our utterly corrupt health minister Matthew Hancock. If people want to overcome this economic arson, they need to always start from the assumption that mischief is afoot. Joshua \| January 19, 2021 at 10:24 am \| Reply Conspiracy theories w/o any actual supporting evidence are so great at explaining everything so completely. RT @RogerPielkeJr: The twisted, messy hunt for COVID-19's origin and the lab leak theory cnet.com/features/the-h… 5 hours ago Denizens Denizens Denizens II jim2 on The big ‘cancel’ Joshua on The big ‘cancel’ James Cross on The big ‘cancel’ jimmww on Looking forward: new technologies in the 2020’s Grant Quinn on Looking forward: new technologies in the 2020’s Franktoo on The big ‘cancel’ mesocyclone on The big ‘cancel’ Committed warming and the pattern effect The big ‘cancel’ COVID-19: why did a second wave occur even in regions hit hard by the first wave? Biden Administration II Looking forward: new technologies in the 2020’s Asymptomatic spread(?) of Covid-19 Week in review – science edition Five rules for evidence communication Cultural motivations for wind and solar renewables deployment Slower decay of landfalling Hurricanes in a warmer world — really? 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__label__wiki	0.701207	0.701207	Transdermal Therapeutic System How to apply TTS Advantages of TTS Manufacturing of TTS What LTS stands for Market Potential of TTS Reasons to choose LTS LTS as partner Transdermal Therapeutic Systems Oral Thin Films Micro Array PatchesNEW LTS Resolution Partner LTS Product videos About LTS LTS Executive Board LTS Supervisory Board History of LTS Figures, Data, Facts Downloads and Web seminars History of LTSLTS2020-04-17T10:41:40+02:00 From the initial vision to a leading partner to the pharmaceutical industry It all started with the vision of a transdermal patch, and has developed into a success story that has lasted to this day: read on for an overview of the history of LTS and its major milestones. The Lohmann Company in Neuwied, West Germany, a specialist in technical adhesive tapes starts developing the idea of transdermal therapeutic systems (TTS). LTS, LOHMANN Therapie-Systeme GmbH & Co. KG is founded as a subsidiary of the Lohmann Group in Neuwied. The first TTS matrix system from LTS achieves approval and is launched, a nitroglycerin patch (Deponit®). LTS´ development, production and quality control departments move into the company’s first independent facility in Neuwied. LTS begins initial development work on oral thin films. The first nicotine patch for smoking cessation is launched in the US – developed and manufactured by LTS. LTS launches the world’s first hormone TTS matrix system (Estradiol patch). LTS Corp. is founded in in West Caldwell (USA); Completion of factory´s reconstruction work LTS moves its headquarters to Andernach. Start of Nicotine-TTS production in the USA. Listerine® Whitening Strip production starts in the USA. LTS is transformed into a non-listed public limited company. The first nicotine patch is approved in Japan. The first oral wafer product is launched and manufactured exclusively by LTS (sold as an oral hygiene product for the end customer). The first buprenorphine patch in the world is approved for treating pain relief and launched in Europe – developed and manufactured by LTS. LTS’s partner Johnson & Johnson launches the world’s first transdermal contraceptive patch (Evra®). LTS starts basic research into microneedles. Development of the first LTS-Fentanyl-TTS for the treatment chronic pain and launch by the LTS partner Nycomed. By using the LTS matrix system the content of the API can be reduced by 35% having the same efficacy. Over 1 Billion Listerine® PocketPacks have been manufactured at LTS For the first time, a therapy is exclusively available as a transdermal system – the world’s first new chemical entity (NCE) for the treatment of Parkinson’s disease – developed and manufactured by LTS. The Exelon® patch (Rivastigmine) from Novartis, with major support from LTS, is approved and launched for the treatment of Alzheimer’s disease. The nicotine patch developed by LTS is approved and launched in Europe. Scientific symposium on TTS –„LTS-Academy“– including key opinion leaders and experts in the field. Launch of Qutenza™ (Astellas/Acorda) the first cutaneous patch with a high concentrate of capsaicin (8 %) for the local treatment of neuropathic pain. Launch of Butrans® in Japan and the USA (Hisamitsu, Purdue) Launch of Exelon® in Japan (ONO) Launch of the Ibuprofen Patch Ibupas® by Sigma Tau; a local analgesic for the treatment of acute or chronical Tennis elbow Launch of Neupro® in Japan (Otsuka) Launch of an Ondansetron OTF for the treatment and prophylaxis of acute nausea and vomiting induced by moderately emetogenic chemotherapy. LTS manufactures the first OTF for the treatment of breakthrough pain in chronic cancer pain. Launch of the first therapeutic equivalent generic version of Suboxone® (buprenorphine and naloxone) sublingual film, in the United States by our partner Dr. Reddy’s. Buprenorphine and Naloxone Sublingual Film is a prescription medicine indicated for treatment of opioid use disorder. The manufacturer’s authorisation for LTS is extended to the manufacturing of capsules. Worldwide at home: the LTS Group With locations in Andernach, West Caldwell and Shanghai, LTS is at home on three continents – for efficient communication, quick access to the market and personal, partnership-based cooperation with our customers and partners. © LTS Lohmann Therapie-Systeme AG,	cc/2021-04/en_middle_0036.json.gz/line896
__label__cc	0.504596	0.495404	Browse Puzzles To take full advantage of all the site's features like saving/loading puzzles, leaderboards, reward points/badges Login or Register Autumn In The Vineyard Autumn In The Vineyard Puzzle Details: About: In today's puzzle we're above a vineyard taking in the breath taking autumn landscape. Row after row of grapevines for as far as the eye can see and the bright autumn colors make this game a fun and relaxing challenge. Pick your difficulty level, click start and give it a try! Puzzle Of The Day On: 22/Oct/2019 Never Miss A Puzzle! Like Us On Facebook DailyJigsawPuzzles.net Very Easy Puzzle Time Stats Easy Puzzle Time Stats Normal Puzzle Time Stats Hard Puzzle Time Stats Very Hard Puzzle Time Stats Extra Hard Puzzle Time Stats Puzzle Leaderboards Login and refresh the page to see leaderboards. Some Other Puzzles In Our Gallery Bench By The Lake Join for a relaxing time by a crystal clear alpine lake. Click start, take a sit on the wooden bench by the lake shore and admire the beautiful mountain landscape -the rocky cliffs, the green pine forest and the grassy meadows. White Fence Solve this fun new puzzle and see the white fence at the edge of a beautiful forest during a foggy Autumn morning. City Nightscape Another urban landscape themed puzzle is here. In this new one we feature a city at at night. Pick your difficulty level, click start and put the beautifully light buildings, the highway and the bridge in the distance back together and take in the impressive urban landscape. Have fun! Large Tree Today's new jigsaw game feature a beautiful landscape centered around a large and impressive tree. Montepulciano View Montepulciano is a medieval and Renaissance hill town and comune in the Italian province of Siena in southern Tuscany. The city, full of elegant Renaissance palaces, ancient churches and beautiful squares boasts vast panoramas all over the Val d'Orcia and Val di Chiana valleys that surround it. Such a view we feature this fun and challenging jigsaw puzzle. Click start and give it a try. Beautiful Lakeside View Join us by the crystal clear mountain lake and take in the beautiful landscape. Featuring a beautiful lakeside view, impressive mountain peaks in the distance, forest covered alpine slopes, the clear and calm waters of the lake and the fluffy white clouds, this nature inspired puzzle will help you relax and give you the challenge you need in a good jigsaw game. Have fun! Two Benches It's a beautiful Autumn day and we're going for a stroll in thee park. Click start and join us for a couple of minutes of relaxation on one of the two benches in the park and take in the colorful Autumn landscape. Have fun! Colorful Rooftops In today's new puzzle we feature a view of some colorful buildings and rooftops in a small corner of Prague. Prague is home to a number of well-known cultural attractions, like the Prague Castle, the Charles Bridge, the Old Town Square with the Prague astronomical clock, the Jewish Quarter and more. So what are you waiting for? Click start, put the old colorful buildings back together and solve today's puzzle. Rocky Landscape In today's puzzle game we feature a beautiful mountain landscape in the center of which stands a large rock formation basking in the bright sun. The image was captured against the alpine blue sky full of fluffy white clouds. The Maroon Bells The Maroon Bells (Maroon Peak and North Maroon Peak) are two distinctively bell-shaped peaks towering 14,000 ft. above the pristine, glacial Maroon Creek Valley. They are part of the Elk Mountains and are located just outside Aspen in Colorado's Rocky Mountains USA. Both peaks are fourteeners (a mountain peak with an elevation of at least 14,000 feet (4267 meters)). Maroon Peak, at 14,163 feet (4317 m), is the 27th highest peak in Colorado. North Maroon Peak, at 14,019 feet (4273 m), is the 50th highest. The Maroon Bells are composed of the Maroon Formation - mudstone. It's a foggy morning in a quiet mountain town and the scenery is so beautiful that it had to be featured in today's new jigsaw. Click start and put the fog covered mountains, the power lines cutting across the meadow and the small path back together as fast as you can an get a place on our leaderboard. Today we're featuring an industrial landscape with four cooling towers. Cooling towers are heat removal devices used to transfer process waste heat to the atmosphere. Cooling towers may either use the evaporation of water to remove process heat and cool the working fluid to near the wet-bulb air temperature or, in the case of closed circuit dry cooling towers, rely solely on air to cool the working fluid to near the dry-bulb air temperature. Didn't find something you like? Don't worry we have thousands of online puzzle games in our gallery for both kids and adults alike. Browse All Puzzles Daily Jigsaw Puzzles - a new online jigsaw puzzle every day. All our puzzles can be played in full-screen mode on your desktop, smart phone or tablet( iPad/iPhone(iOS) or Android powered devices). DailyJigsawPuzzles.net is your free iPad (or Android tablet) jigsaw puzzle app. Just visit using your mobile device and play our HTML5 powered puzzles. What is a jigsaw puzzle? Jigsaw Variations Jigsaw Pieces Jigsaw puzzle solving strategies Download Jigsaw Puzzles User Leaderboard The Jigsaw Puzzles Gallery Cookies Policy / Privacy Policy Manage Consent Preferences This site uses cookies to deliver its services and to analyze traffic. For more information please read out Cookie & Privacy Policies. Third-party trademarks are used solely for describing the games indexed herein and no license or other affiliation is implied.	cc/2021-04/en_middle_0036.json.gz/line900
__label__wiki	0.980004	0.980004	NCA NewsWire ‘Ridiculous’: PM blasted for border backflip by Samantha Maiden 6th Jul 2020 5:32 PM Scott Morrison has officially backflipped over his calls to keep borders open across Australia and will now support NSW's decision to issue turnback orders for Victorian travellers. News.com.au understands the Prime Minister has indicated to NSW Premier Gladys Berejiklian in a phone call this morning that he understands the decision to shut the border with Victoria. Despite arguing for months that border closures in Queensland and WA were not required, he's now accepted the rising rate of community transmission in Victoria has changed the game. But the change of heart has prompted angry premiers to demand the Morrison Government drop its intervention in a "ridiculous" High Court challenge being backed by businessman Clive Palmer into the border closures. Those legal challenges are set to be argued in the Federal Court on Monday, July 13 and 14. The Prime Minister has consistently argued the health advice does not support border closures, conceding it was up to the state premiers to decide but warning it is costing jobs. So, what's changed? The simple answer is that the Prime Minister has accepted that the rising rates of community transmission in Victoria - previously unseen in Australia - has justified the first border closure between NSW and Victoria in 100 years. RELATED: Top cop warns of strict border tactics RELATED: Victorians face jail for entering NSW From midnight Tuesday the border between NSW and Victoria will close. Picture: Supplied Previously, when Victoria had higher rates of new cases at the beginning of the pandemic it related to foreign travellers returning from overseas. This time, confirmation that the virus is being transmitted in the community, and in the high rise public housing communities with shared lifts and laundries that have been compared to cruise ships, is a far more alarming prospect. WA Premier Mark McGowan said it was now time for premiers and prime ministers to stop telling other leaders what to do with their borders. "I think premiers should be able to make the decision in the interests of their own state without others trying to tell them what to do," he said. "I've advised all the other premiers and the prime minister that we need to keep our border in place until it's safe to bring it down. Now obviously that's copped some criticism, but I think the cautious, considered and careful approach has paid dividends … and we intend to keep doing that." New South Wales Premier Gladys Berejiklian announces the closures of the NSW state border to Victoria. Picture: NCA NewsWire / Jeremy Piper The WA premier said the High Court challenge Mr Palmer should now be scrapped. "The best thing that could happen now is Mr Palmer withdrawing his High Court challenge and the Commonwealth stopped supporting him," he said. "Clearly there is no basis to this high court challenge now, especially the Commonwealth, so I've written to the Prime Minister today - I've contacted him personally - to indicate I think it's appropriate now they withdraw this legal action." "Quite frankly, the legal challenge, and especially the commonwealth involvement in it, has now become completely ridiculous." "This nonsense has to stop, and it has to stop now." On June 18, the Prime Minister complained that the border closures were costing "5,000 jobs a week". "This is why borders should be opened up. There's never been any advice which says they should be closed," the Prime Minister told 2GB radio. "And that's why this is so frustrating. I'm pleased that we've got a timetable at least now. And that's important because that means that particularly the tourism industry up in Queensland can now start planning to take people again when that turns back on. "But there was no reason for the borders to be shut in the first place. And so they need to be reopened." Last month, Attorney-General Christian Porter announced the Commonwealth would join the High Court dispute over WA border closures brought by businessman Clive Palmer, claiming "there's a very strong argument that it's unconstitutional". "Well it's not the Commonwealth Government's action. I mean this is private citizens arguing that the border closure in the present circumstances is unconstitutional and that is their right,'' Mr Porter said. "(But) calling someone selfish for arguing a constitutional right is something that I strongly disagree with." The PM has officially backflipped on borders as Victoria’s spike spirals out of control. Picture: NCA NewsWire / Terry Cunningham Across Australia, the complex state of play of border restrictions is a patchwork across the nation. The ACT's and Victoria's borders remain open. The NSW border will be closed to Melburnians from midnight tonight and to all Victorians from midnight on Tuesday. In Tasmania, all non-essential travellers arriving on the island need to quarantine for 14 days. In SA, people travelling from NSW and the ACT are required to self quarantine on arrival. There are no restrictions for travellers from other states. The WA Premier said it was clear what was happening in Victoria was new and different. "The level of community spread inside Victoria is something that we haven't seen before in this country,'' he said. "There is no doubt about it - as a nation we are entering a new and dangerous phase of this pandemic. Victoria is doing all it can to bring the situation under control." Treasurer Josh Frydenberg, who had previously opposed border closures adopted a softer approach on Monday when asked if other states will have to take tougher action. "Let's see what happens in the next couple of weeks. It is a challenging period," he said. Originally published as 'Ridiculous': PM blasted for border backflip Premium Content 'Concerning': Teen tourist COVID positive after faulty test border editors picks new south wales premiers prime minister victoria	cc/2021-04/en_middle_0036.json.gz/line901
__label__cc	0.746633	0.253367	If you have never registered in the MAGIC-NEXUS Project website, you will need to create a new account before you can login. Just fill in the form with your desired username and e-mail address. Please choose a username that you will remember easily. Usernames must have at least 5 and not more than 60 characters (letters and numbers), and contain no punctuation except for periods, hyphens, apostrophes and underscores. Why do you need to register? By completing the MAGIC-NEXUS Project registration process, you are creating a secure personal account that will provide you with access to features that are not available without registration such as the ability to post in the “Discussion Forum” and “Ask a Question” sections, or to comment “The Nexus Times” articles. Please note that registration is not mandatory and is subject to approval from the MAGIC-NEXUS Project team. Once it has been approved, you will receive an e-mail containing information about how to login and set your password. By clicking on "Create new account" button below, you are agreeing to the Terms of Use and the Privacy Policy of this website. If you have already registered to MAGIC-NEXUS Project website, you can login here. The Nexus Times Newsletter	cc/2021-04/en_middle_0036.json.gz/line903
__label__wiki	0.903411	0.903411	Public Accounts Committee to consider PM proposal 20 percent pay cut to MPs salary THE Public Accounts Standing Committee is considering a motion from the Hon. Prime Minister for a 20 percent cut in legislator’s basic salary due to the impacts of COVID-19. The House voted to send the Prime Minister’s motion to the Public Accounts Committee to consider it before reporting to the House. The Deputy Speaker, Lord Tu’iha’angana criticized how the motion was tabled in Parliament. He said there are other avenues where it could have been circulated for approval by MPs rather than discussing it publicly. Lord Tu’iha’angana said the Prime Minister first preached the need for Parliament to collaborate for the good of the country. Yet, the PM did not consult the MPs first on the issue. Ha’apai number 1 Noble Representative Lord Tu’iha’angana made reference to the Prime Ministers of New Zealand and Fiji who made similar announcements amid concern over COVID-19. No opposition was reported. Lord Tu’iha’angana said this probably because the MPs were consulted on the matter. He urged parliamentarians to consider a 20 percent pay cut and for the Remuneration Authority to handle the matter. The announcement was met with resistance from some Members. The Deputy Speaker argued the Remuneration Authority has no authority over the MPs’ salary. He said it would have been appropriate should PM talked it over first with the legislators. Tongatapu 2 MP, Semisi Sika challenged the PM to exempt all MPs from the motion and they make the sacrifice to work without pay. Their full pay will assist the COVID-19 prevention activities. Sika also mentioned the PM made a vague explanation of his motion. In response, the Minister of Police, Lord Nuku explained there is urgency for funds available to finance the work overtime of front-liners including police officers and nurses. He claimed they worked after hours, but no funds available to finance it. Tongatapu 4 MP, Mateni Tapueluelu also rejected the motion and labeled it as the PM’s political campaign. He suggested the MPs hospitality funds and other means which Parliament can sacrifice instead of the pay cut proposal. Siaosi Pōhiva, Tongatapu 1 MP also pointed out the biblical perspective on giving generously to the needy. “When we give to the needy, do not let your left hand know what your right hand is doing so that your giving may be secret,” said Mr. Pōhiva. He said the PM should not have publicly announced the move. Instead, he should have approached the pay-clerk and arranged for his 20 percent pay cut. The former Health Minister Saia Piukala was disappointed about the PM’s remarks on his political People’s Party manifesto. Piukala said when this was mentioned, it clearly demonstrates party politics remains an obstacle for a unified Parliament. He said the PM is the head of Government, and therefore should act professionally (have more patience, loving) and acted in a matter to unite Parliament. In response, Hon. Tu’i’onetoa clarified the rationale behind his motion. It is simply a plea for Parliament to consider giving to those who were affected due to the impacts of COVID-19. “It was with the impression that all legislators including myself and the Cabinet Ministers lead by example in contributing to the most vulnerable ones impacted by the pandemic. This includes those who have lost their job,” said the PM. He added the MPs' contribution is a demonstration to ordinary citizens, they feel what they are experiencing during this difficult time. The PM also denied Tongatapu 2 MP motion. He said this defeats the purpose of his motion, to involve all MPs in the process. Hon. Tu’i’onetoa said his motion was prompted due to the global impacts of the coronavirus pandemic which also affects Tonga. To date, Tonga is among ten countries in the world that is COVID 19 free. The Hon. Prime Minister also mentioned the move because of the biggest budge deficit about 60 million forecasted by the government. Hon. Tu’i’onetoa also mentioned that despite the challenges Tonga is facing, Parliament should be reminded and should have faith that God is our refuge and fortress. “God will fight for us, he will build our nation. And through hard work and the concerted effort in everything we do, we’ll build Tonga economically and socially for a stable economy for all,” said the Hon. PM. The PM was also confident that through national prayer and fasting in April and earlier this month, it strengthens Cabinet's will to continue serving the people. He also extended an invitation for the MPs participation in the same exercise on June 6-7. The PM firmly believed it is through praying and fasting is the only means to protect and safeguard Tonga from COVID-19. Dr. Pōhiva Tu’i’onetoa also pointed out that Tonga should strengthen their belief that God is our protector. “Praying and fasting can cast away all fears relating to COVID 19, it gives family peace and comfort,” said the Hon. Prime Minister. Coronavirus and the impacts of climate change which led to more frequent natural disasters like Tropical Cyclones Tino and Harold are among threats the current government administration had faced since came into power late last year.	cc/2021-04/en_middle_0036.json.gz/line905
__label__wiki	0.891301	0.891301	● / Film Soviets, Sundays and a Salford taboo - the story of UK’s oldest film society Vicky Smith 10 December 2020 Manchester & Salford Film Society recently celebrated its 90th anniversary…and its president is 98 RSPB, Vegetarian, Co-Op…Greater Manchester has a rich history of forming societies, including some of Britain’s most familiar charities. But did you know it also boasts the UK’s oldest film society? The Manchester & Salford Film Society celebrated its 90th anniversary last month. What’s more, it’s still headed by president Marjorie Ainsworth (now 98), who joined when she was just 17 after being encouraged by her future husband Tom. “He’d joined when he was 16, the age you were allowed to join a film society by statute,” she said. “I was amazed, I didn’t know there were films outside of Britain and Hollywood; it opened up the world.” Marjorie Ainsworth (right): “Watching films helps you stay in the zeitgeist, and guarantees you won’t have a mouldy old age” The society was first established by the local trades councils as the Salford Workers’ Film Society in 1930, during a turbulent period of high international political activity and tension, when ‘a group of young Salford men became fired up with the potential power of films. They realised that films could not only entertain but also educate and politicise.’ Initially they watched mainly Russian films at Princes Cinema in Liverpool Street…until the Salford Watch Committee forbid a Storm Over Asia due to its unflattering view of the British army. Manchester allowed the film, leading the society to find a venue there, and (with the additional dropping of ‘workers’ from the title due to a change in membership demographics) it ultimately became known as the Manchester & Salford Film Society - showing arthouse films and world cinema to a wide audience. An early programme from the Salford Workers' Film Society Working Class Movement Library When Ainsworth first joined, cinemas weren’t permitted to open on Sundays, meaning the society was able to rent them fully - “we used to take a 35mm projector and we’d have the place all to ourselves.” Once a bill passed permitting their Sunday opening in 1957, however, things became more difficult: “We had to go to all sorts of weird places to show films!” Subsequent venues included the YMCA and even the United States Information Service, before they found a suitable premise in the new meeting hall of Manchester Literary and Philosophical Society (of which she and husband Tom were also members). Unfortunately it collapsed after 18 years, due to being built “with some super high aluminous cement, which was all the rage in the fifties” but clearly unfit for purpose. Next up was Platt Chapel, brought by the Amateur Photographic Society of which Tom was a part. But again it wasn’t ideal: pews needed removing and a toilet and central heating needed installing - as did a false ceiling, the chapel’s high pointed roof so distorting acoustics they could only watch subtitled films. Despite ongoing renovations, attendance started to dwindle…until member John Grieve suggested the society’s current venue, Altrincham’s Little Theatre. The society is now based at Altrincham’s Little Theatre “It has a bar, is comfortable, has proper-rate seats and a big screen” the lively nonagenarian chuckles approvingly, also commending Grieve for raising membership ‘sixfold’ during his tenure as the society’s secretary. Ever adaptable, the group is currently hosting screenings and quizzes online due to COVID-19 but she looks forward to socialising in person once again. Alongside its interesting programme, the community aspect is clearly something still valued by all members in an age where streaming or going or to see films (in non-COVID times at least) has never been easier. Special events have been another key element throughout the society’s history, from talks by studios like Cosgrove Hall (featuring its famed Wind in the Willows puppets) to weekends away with other British film societies; including North West locations such as Lyme Hall and Burton Manor. “There was always somewhere to go, something to do and wonderful people to meet,” she says; listing acquaintances like acclaimed critic Dilys Powell, silhouette animation pioneer Lotte Reiniger and Halas and Batchelor, the director couple behind cartoons like Animal Farm. Talks have included BAFTA-winning Chorlton studio Cosgrove Hall, whose Wind in the Willows puppets were recently returned to Manchester Themed trilogies are another staple, with Ainsworth cooking up cuisine to match; from curry for Satayajit Ray’s Apu trilogy to borscht for a Polish series. Catering is one of many roles she has played at the society - committee member, treasurer, programme note writer, celluloid film splicer, ‘general factotum’ - all over eight decades of membership. Unsurprisingly, the retired teacher and her late husband are considered film industry icons in their own right; known for their generosity and dedication, both within their own film society and with helping others found theirs - even Granada Studios, to whom the couple would lend projectors for its own staff club. Both have been awarded the prestigious Roebuck Cup by Cinema for All, formerly the British Federation of Film Societies, with Tom being presented his by American actor Tony Curtis in 1984. Manchester & Salford Film Society now runs a short film competition in Tom’s memory, with the North West's most talented student film-makers invited to compete for prizes. In 2016, Marjorie Ainsworth was awarded the Roebuck Cup by Cinema for All (which Reg Cordwell, one of Manchester & Salford Film Society’s founder-members, helped launch in 1946) Way back in 1930 the society’s manifesto stated that its purpose was ‘to cater for those who are dissatisfied with the average productions of the commercial cinema, with their shallowness and divorce from reality, and to offer in their stead films more closely in sympathy with the life and thought of this age.’ Now in its 89th season, the volunteer-led organisation holds true to those words; focusing on ‘thought-provoking cinema, seldom shown at the multiplex.’ While its usual likes of annual dinner and theatre visits are off the cards for now, it continues to entertain online with an eclectic mix of classic and contemporary films chosen by members. Marjorie Ainsworth’s advice? “Watching films helps you stay in the zeitgeist, and guarantees you won’t have a mouldy old age.” If she’s anything to go by, we don’t doubt it. mandsfilmsociety.org.uk Working Class Movement Library: Man With a Movie Camera Salford's Working Class Movement Library, home to the Manchester & Salford Film Society archive, is currently celebrating the society's 90th birthday with an online series of events. Next up, on Wednesday 16 December at 7.30pm, Andy Willis - professor of film studies from the University of Salford - will host a discussion on Dziga Vertov’s avant-garde silent documentary Man With a Movie Camera, often voted amongst the best cinema ever made and ‘an exuberant manifesto that celebrates the infinite possibilities of what it can be’ according to one critic. This film was first screened by what was then the Manchester and Salford Workers’ Film Society on 24th October 1931, with attendees including Ewan MacColl: ‘The opportunity of seeing films of such stature compensated for some of the deprivation experienced by an ill-educated adolescent who faced the bleak prospect of trying to earn a living in the arid desert of 1930’ (Journeyman, 1990). Attendees will be encouraged to watch the film on YouTube before the event, with accompanying notes provided by the Film Society, and then join up live with others on the 16th to discuss what they have seen. As is usual with the library’s talks and exhibitions, the event is free to attend, although donations are much appreciated at this difficult time. More details can be found here. Read more: ‘Little short of a pantomime’ - culture leaders react to Tier 3 announcement ● / Health + Fitness Manchester’s most innovative gym concept creates advanced home fitness solution Move over Wicks - Bez is launching his own YouTube fitness classes ● / Best of MCR Top things to do in Manchester: January 2021 A month by month account of the omnishambles that was 2020 up north	cc/2021-04/en_middle_0036.json.gz/line907
__label__cc	0.738355	0.261645	LGiU About LGIU Global-Local Pandemic Bulletin Facts and figures: England Facts and figures: Scotland Facts and figures: Ireland Facts and figures: Australia Home > Articles by: Andy Sawford Author: Andy Sawford Search Years: All years 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Big Society means government by citizens, for society Writing in the Evening Standard this week, Matthew Dancona makes a spirited defence of the Big Society. He veers around the subject, pivoting on what he sees as the ideological underpinning of Cameron’s big idea – the small state. This pitching of state against society, government against citizen, really misses the point. Government should be… 11th February 2011 England & Wales Blog Post Councils can revive Cameron’s Big Society idea When the LGIU brought together a group of council Leaders to meet with Lord Nat Wei – David Cameron’s Big Society guru – along with officials at Communities and Local Government and the Cabinet Office, we shed some light perhaps on why the Big Society isn’t taking off. The first is that whilst many… Council tax cap of 3.5% Eric Pickles has announced a cap of 3.5% on council tax rises for this year’s budgets from April 2011 to April 2012. The Government has previously announced that councils who set an increase of less than 2.5% will be refunded the money. Although council’s are facing huge budget cuts it seems unlikely that they will opt to set council tax increases above… 9th February 2011 England & Wales Blog Post Local government finance review must be wide ranging After speaking with Greg Clark last week I have high expectations for the government’s announcement on the review of local government finance. It seems though that there is a conflict at the heart of the coalition about how ‘radical’ to be. Allister Hayman over at LGC has more on this. My two pennyworth, which I… 20th January 2011 England & Wales Blog Post LGIU Briefing on the Localism Bill Overview Localism is a main theme of current government policy, and the Localism Bill is presented as the main vehicle for measures that will strengthen the capacity of communities and individuals to find local solutions to local problems. The pursuit of localism, seen from LGiU’s perspective, takes the form of strengthening local democracy by putting… Job vacancies at LGIU We’re currently welcoming applications for two new roles here at the Local government Information Unit. DRAFT: 2012 local elections information and predictions This May around 5000 council seats will be contested in 127 councils in England, 32 Scottish local authorities and 22 Wales. The local elections will be held on Thursday 3 May, the same day as Mayoral contests in Liverpool and Salford and referendums on whether to adopt the Mayoral model in 10 cities. There is… 2nd January 2011 England & Wales Blog Post The localism bill: the key points for councils This article was origianlly publish on the Guardian website A massive piece of legislation announced alongside a huge cut in funding for local government, the localism bill will have a big impact on local councils and communities. Looked at carefully, it’s clear the bill provides practical reasons to believe that the relationship between citizens and… 22nd December 2010 England & Wales Blog Post Tough settlement: oh yes, it is This article was originally published on the Public Finance blog In the 36 hours since the local government finance settlement was announced I’ve heard accusations of ‘spin’ by the government, and ‘whingeing’ by councils. Local Government Secretary Eric Pickles claims that the maximum funding reductions are 8.9%. But in this season of pantomime, councils are… 16th December 2010 England & Wales Blog Post Reaction to Localism Bill These announcements will each have a huge impact on local councils and local communities. Together they represent unprecedented change in our public services and in the governance of Britain. The finance settlement will be very tough for councils and there is no doubt that some, if not all, will have to make major cuts in… LGIU (Local Government Information Unit) has offices in England, Scotland and Ireland. e: info@lgiu.org About LGIU England & Wales About LGIU Scotland About LGIU Ireland About LGIU Australia Don't miss out on any of our local government posts, research and events. If you are a member make sure you receive Daily News and members only briefings and reports.	cc/2021-04/en_middle_0036.json.gz/line911
__label__wiki	0.637435	0.637435	“McClintock Distilling Named BEST Vodka Distillery in Country by USA Today” – Yahoo! Finance October 5, 2020 by Jim Bauckman From Release FREDERICK, Md., Oct. 2, 2020 /PRNewswire-PRWeb/ — McClintock Distilling was named the number one Best Craft Vodka Distillery in the nation by USA Today. The distillery was also recognized as the fourth Best Craft Gin Distillery in the U.S. by the most widely read news publication in the country. These high honors for the Epiphany Organic Vodka and the distillery’s three varietals of artisanal gin solidify McClintock as a name to watch in the spirits industry. “We are truly honored to win best vodka distillery in the country and fourth best gin distillery from the USA Today competition. We were certainly surprised as a small, organic distillery to be considered in the competition and very thankful that our community supported us,” said Braeden Bumpers, co-owner of McClintock Distilling. “We are proud of this national recognition that represents the growing and vibrant distilling community in our state. Maryland is quickly regaining its pre-prohibition reputation for making some of the best spirits in the country. To continue reading this article at Yahoo! Finance, click here.	cc/2021-04/en_middle_0036.json.gz/line920
__label__wiki	0.663298	0.663298	Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging Kirsten P. Forbes, James G. Pipe, John P. Karis, Joseph E. Heiserman PURPOSE: To compare periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) multishot fast spin-echo diffusion-weighted magnetic resonance (MR) imaging with single-shot echo-planar diffusion-weighted MR imaging for image quality and visualization of acute cerebral infarction. MATERIALS AND METHODS: Seventy subjects (35 men, 35 women; mean age, 55 years ± 24 [SD]) who were suspected of having acute cerebral infarction (symptom duration, 2.8 days ± 2.7) underwent PROPELLER and echo-planar MR imaging (b = 1,000 sec/mm2). Two neuroradiologists compared unlabeled images for presence of artifacts, visualization of infarction, and their preference of images. Interobserver agreement and image comparison were assessed by using the κ statistic and the χ2 test, respectively. RESULTS: PROPELLER MR imaging reduced susceptibility artifacts (n = 70 subjects), which limited visualization of temporal (echo-planar, n = 64; PROPELLER, n = 0; P < .01, χ2 test), frontal (echo-planar, n = 58; PROPELLER, n = 1; P < .01), and parietal lobes (echo-planar, n = 5; PROPELLER, n = 0; P < .05) and cerebellum (echo-planar, n = 36; PROPELLER, n = 0; P < .01) and brainstem (echo-planar, n = 23; PROPELLER, n = 0; P < .01). Acute infarction (n = 31 subjects) was better demonstrated at PROPELLER MR imaging (PROPELLER better, n = 18; echo-planar better, n = 1; PROPELLER and echo-planar equal, n = 12; P < .01, χ2 test). PROPELLER MR imaging was preferred in all (n = 70) but one case in which the lesion lay within the intersection gap (PROPELLER preferred, n = 69; echo-planar preferred, n = 1; P < .01, χ2 test). CONCLUSION: With a short increase in imaging time, PROPELLER MR imaging offers better image quality and detection of acute cerebral infarction than does echo-planar MR imaging. https://doi.org/10.1148/radiol.2252011479 Brain, infarction Magnetic resonance (MR), diffusion study Magnetic resonance (MR), k-space Magnetic resonance (MR), pulse sequences 10.1148/radiol.2252011479 Fingerprint Dive into the research topics of 'Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging'. Together they form a unique fingerprint. Diffusion Magnetic Resonance Imaging Medicine & Life Sciences Cerebral Infarction Medicine & Life Sciences Echo-Planar Imaging Medicine & Life Sciences Magnetic Resonance Imaging Medicine & Life Sciences Artifacts Medicine & Life Sciences Infarction Medicine & Life Sciences Parietal Lobe Medicine & Life Sciences Cerebellum Medicine & Life Sciences Forbes, K. P., Pipe, J. G., Karis, J. P., & Heiserman, J. E. (2002). Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging. Radiology, 225(2), 551-555. https://doi.org/10.1148/radiol.2252011479 Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging. / Forbes, Kirsten P.; Pipe, James G.; Karis, John P.; Heiserman, Joseph E. In: Radiology, Vol. 225, No. 2, 01.11.2002, p. 551-555. Forbes, KP, Pipe, JG, Karis, JP & Heiserman, JE 2002, 'Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging', Radiology, vol. 225, no. 2, pp. 551-555. https://doi.org/10.1148/radiol.2252011479 Forbes KP, Pipe JG, Karis JP, Heiserman JE. Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging. Radiology. 2002 Nov 1;225(2):551-555. https://doi.org/10.1148/radiol.2252011479 Forbes, Kirsten P. ; Pipe, James G. ; Karis, John P. ; Heiserman, Joseph E. / Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging. In: Radiology. 2002 ; Vol. 225, No. 2. pp. 551-555. @article{974b4f31156e4fbd8102db5bd5f31b3e, title = "Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging", abstract = "PURPOSE: To compare periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) multishot fast spin-echo diffusion-weighted magnetic resonance (MR) imaging with single-shot echo-planar diffusion-weighted MR imaging for image quality and visualization of acute cerebral infarction. MATERIALS AND METHODS: Seventy subjects (35 men, 35 women; mean age, 55 years ± 24 [SD]) who were suspected of having acute cerebral infarction (symptom duration, 2.8 days ± 2.7) underwent PROPELLER and echo-planar MR imaging (b = 1,000 sec/mm2). Two neuroradiologists compared unlabeled images for presence of artifacts, visualization of infarction, and their preference of images. Interobserver agreement and image comparison were assessed by using the κ statistic and the χ2 test, respectively. RESULTS: PROPELLER MR imaging reduced susceptibility artifacts (n = 70 subjects), which limited visualization of temporal (echo-planar, n = 64; PROPELLER, n = 0; P < .01, χ2 test), frontal (echo-planar, n = 58; PROPELLER, n = 1; P < .01), and parietal lobes (echo-planar, n = 5; PROPELLER, n = 0; P < .05) and cerebellum (echo-planar, n = 36; PROPELLER, n = 0; P < .01) and brainstem (echo-planar, n = 23; PROPELLER, n = 0; P < .01). Acute infarction (n = 31 subjects) was better demonstrated at PROPELLER MR imaging (PROPELLER better, n = 18; echo-planar better, n = 1; PROPELLER and echo-planar equal, n = 12; P < .01, χ2 test). PROPELLER MR imaging was preferred in all (n = 70) but one case in which the lesion lay within the intersection gap (PROPELLER preferred, n = 69; echo-planar preferred, n = 1; P < .01, χ2 test). CONCLUSION: With a short increase in imaging time, PROPELLER MR imaging offers better image quality and detection of acute cerebral infarction than does echo-planar MR imaging.", keywords = "Brain, infarction, Magnetic resonance (MR), diffusion study, Magnetic resonance (MR), k-space, Magnetic resonance (MR), pulse sequences", author = "Forbes, {Kirsten P.} and Pipe, {James G.} and Karis, {John P.} and Heiserman, {Joseph E.}", doi = "10.1148/radiol.2252011479", journal = "Radiology", publisher = "Radiological Society of North America Inc.", T1 - Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging AU - Forbes, Kirsten P. AU - Pipe, James G. AU - Karis, John P. AU - Heiserman, Joseph E. N2 - PURPOSE: To compare periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) multishot fast spin-echo diffusion-weighted magnetic resonance (MR) imaging with single-shot echo-planar diffusion-weighted MR imaging for image quality and visualization of acute cerebral infarction. MATERIALS AND METHODS: Seventy subjects (35 men, 35 women; mean age, 55 years ± 24 [SD]) who were suspected of having acute cerebral infarction (symptom duration, 2.8 days ± 2.7) underwent PROPELLER and echo-planar MR imaging (b = 1,000 sec/mm2). Two neuroradiologists compared unlabeled images for presence of artifacts, visualization of infarction, and their preference of images. Interobserver agreement and image comparison were assessed by using the κ statistic and the χ2 test, respectively. RESULTS: PROPELLER MR imaging reduced susceptibility artifacts (n = 70 subjects), which limited visualization of temporal (echo-planar, n = 64; PROPELLER, n = 0; P < .01, χ2 test), frontal (echo-planar, n = 58; PROPELLER, n = 1; P < .01), and parietal lobes (echo-planar, n = 5; PROPELLER, n = 0; P < .05) and cerebellum (echo-planar, n = 36; PROPELLER, n = 0; P < .01) and brainstem (echo-planar, n = 23; PROPELLER, n = 0; P < .01). Acute infarction (n = 31 subjects) was better demonstrated at PROPELLER MR imaging (PROPELLER better, n = 18; echo-planar better, n = 1; PROPELLER and echo-planar equal, n = 12; P < .01, χ2 test). PROPELLER MR imaging was preferred in all (n = 70) but one case in which the lesion lay within the intersection gap (PROPELLER preferred, n = 69; echo-planar preferred, n = 1; P < .01, χ2 test). CONCLUSION: With a short increase in imaging time, PROPELLER MR imaging offers better image quality and detection of acute cerebral infarction than does echo-planar MR imaging. AB - PURPOSE: To compare periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) multishot fast spin-echo diffusion-weighted magnetic resonance (MR) imaging with single-shot echo-planar diffusion-weighted MR imaging for image quality and visualization of acute cerebral infarction. MATERIALS AND METHODS: Seventy subjects (35 men, 35 women; mean age, 55 years ± 24 [SD]) who were suspected of having acute cerebral infarction (symptom duration, 2.8 days ± 2.7) underwent PROPELLER and echo-planar MR imaging (b = 1,000 sec/mm2). Two neuroradiologists compared unlabeled images for presence of artifacts, visualization of infarction, and their preference of images. Interobserver agreement and image comparison were assessed by using the κ statistic and the χ2 test, respectively. RESULTS: PROPELLER MR imaging reduced susceptibility artifacts (n = 70 subjects), which limited visualization of temporal (echo-planar, n = 64; PROPELLER, n = 0; P < .01, χ2 test), frontal (echo-planar, n = 58; PROPELLER, n = 1; P < .01), and parietal lobes (echo-planar, n = 5; PROPELLER, n = 0; P < .05) and cerebellum (echo-planar, n = 36; PROPELLER, n = 0; P < .01) and brainstem (echo-planar, n = 23; PROPELLER, n = 0; P < .01). Acute infarction (n = 31 subjects) was better demonstrated at PROPELLER MR imaging (PROPELLER better, n = 18; echo-planar better, n = 1; PROPELLER and echo-planar equal, n = 12; P < .01, χ2 test). PROPELLER MR imaging was preferred in all (n = 70) but one case in which the lesion lay within the intersection gap (PROPELLER preferred, n = 69; echo-planar preferred, n = 1; P < .01, χ2 test). CONCLUSION: With a short increase in imaging time, PROPELLER MR imaging offers better image quality and detection of acute cerebral infarction than does echo-planar MR imaging. KW - Brain, infarction KW - Magnetic resonance (MR), diffusion study KW - Magnetic resonance (MR), k-space KW - Magnetic resonance (MR), pulse sequences U2 - 10.1148/radiol.2252011479 DO - 10.1148/radiol.2252011479 JO - Radiology JF - Radiology	cc/2021-04/en_middle_0036.json.gz/line922
__label__cc	0.652904	0.347096	★ Market InsightsCommoditiesEnergy & EnvironmentTransportation How Investors Can Participate in the Hydrogen Economy By McAlinden Research Partners October 1, 2020 No Comments Hydrogen fuel cell technology has been derogatively dismissed as “fool cell” technology, with many doubting it can gain traction. But, after decades of false starts, it looks like they hydrogen economy is finally poised to take off as governments and private companies announce initiatives that will grow hydrogen’s share in the power generation mix. Related Stocks: Linde (LIN), Air Products & Chemicals (APD), Plug Power (PLUG), Ballard Power Systems (BLDP), Bloom Energy (BE), ITM Power (ITM), FuelCell Energy (FCEL), AFC Energy (AFC) In the clean energy space, most of the attention goes to solar, wind and maybe even hydropower. In the automotive space, the lion’s share of attention goes to battery-powered electric vehicles (BEVs). But these are not the only options on the market for zero-carbon energy. In fuel cell form, hydrogen can power everything from vehicles to buildings to power tools, and it does so without emitting carbon. In simple terms, the technology works as follows: hydrogen fuel cell vehicles combine hydrogen stored in a tank with oxygen from the air to produce electricity. That activity powers the car, emitting water vapor as the only by-product. On the subject of using hydrogen to power cars, MRP has previously written that: “While fuel cells pose no threat to batteries’ dominance in transportation, dismissing hydrogen and fuel cells would be as premature as dismissing solar in the early 2000s, or wind in the mid-1990s. The sector’s growth continues to track, and possibly exceed, the earlier trajectories for solar and wind energy.” Not everyone is convinced. Fuel cell technology has long been considered too costly and impractical, and many people have expressed doubt that it can gain traction. Tesla CEO Elon Musk famously dismissed hydrogen fuel cells as ‘fool cells’ and ‘mind-bogglingly stupid.’ For some reason, Mr. Musk’s reaction brings to mind how former Microsoft CEO Steve Balmer also famously laughed at the iPhone in 2007, calling it the “most expensive phone in the world and it doesn’t appeal to business customers because it doesn’t have a keyboard.” It is certainly true that hydrogen fuel cells have been touted for over two decades as the next miracle in transportation fuel, with little to show in terms of mass adoption. But we are now witnessing one important catalyst that could help the industry take off… To read the rest of this Market Insight, START A FREE TRIAL You’ll also gain access to: Our Daily Investment Insights Joe Mac’s Market Viewpoints All of MRP’s Active Thematic Investment Reports MRP’s Entire Research Library If you already have a subscription, sign in AFCAPDBEBLDPEnergyEVsFCELFuel CellGreenHydrogenITMLINPLUGStocks Previous PostEV Chargers vs Gas Stations: The Clock is Ticking Next PostGaming Sales Soar as Industry Preps Next-Gen Console Launches	cc/2021-04/en_middle_0036.json.gz/line923
__label__cc	0.681898	0.318102	Joseph Newman: Magnetic Motor - A montage of Newman's work Submitted by esaruoho on September 28, 2008 - 03:26 This video is my compilation from various videos about Joseph Newman's work on his Magnetic Motor. Joseph Newman has always been a controversial figure for his invention and his theories such as Unified Mechanical Field Theory, Gyroscopic Particles etc. February 22, 1996 - The Sun Weekly (Australian paper) on John Searl Submitted by esaruoho on July 1, 2008 - 03:43 THE SUN WEEKLY (Australian paper) Date - Thursday Feb 22 1996 Recent UFO sightings in the area "are quite possibly the work of government and military intelligence organisations" which are testing technologies that have been kept secret for more than 50 years. The startling claims have been made by a Kincumber engineer who once worked with an English-based professor who invented an energy source in the 1940s.	cc/2021-04/en_middle_0036.json.gz/line933
__label__wiki	0.690601	0.690601	Science at the Olympics: Team Science By the Editor on July 23, 2012 in Around_the_Web Science has had a hand in every aspect of the Olympic and Paralympic Games. For the thousands of athletes, researchers have helped to develop training techniques, schedules, diet, equipment and doping checks. For the millions of spectators about to descend on London, they have contributed to urban planning, crowd control, public health and security. For the billions watching at home, they have shaped the technology that will measure athletic feats and beam them worldwide. Yet those scientists toil in the background, understandably overshadowed by the sporting spectacle. Here, Nature profiles four scientists whose work will contribute to the giant human experiment that is the Olympic Games. Tags:BIG Problems, BIG Questions, Culture, Genetics, Technoscience, Values & Virtues	cc/2021-04/en_middle_0036.json.gz/line935
__label__cc	0.649054	0.350946	Thursday Movie Picks: Gangsters Thursday Movie Picks November 1, 2018 Now that October is over, I can breathe a little easier. Until I’ll have to do this horror month all over again next year. But let’s talk about this week’s theme, which actually ended up being an easier one. Which is surprising, because I don’t necessarily watch a lot of movies about gangsters. 1. LOCK, STOCK AND TWO SMOKING BARRELS (1998) Little less known gem from Guy Ritchie’s youth that put Jason Statham and Vinnie Jones on the map. And though I prefer to call Snatch. my favourite, Lock, Stock and Two Smoking Barrels is a nice introduction to Ritchie’s cinematography. Oh, and it has hard gangsters, which is why I’m recommending it this week! Look at me, mentioning the classics casually as if I know what I’m talking about. But honestly though, I’ve only seen the first film of the trilogy and I’m ashamed. Then again, I’ve at least seen the first and I can honestly tell, it’s a really good gangster film! Like.. really good, right?! 3. GOODFELLAS (1990) This one I saw just recently thanks to the Blindspot challenge I’m taking part of this year! And since it’s quite fresh in my mind, I have to say, I liked it a lot. It had all the right elements of a gangster movie, and it had great performances through and through. It’s hard to go wrong with Goodfellas, when you’re in the mood for some gangsters. THIS SERIES IS CREATED BY WANDERING THROUGH THE SHELVES GoodfellasLock Stock and Two Smoking BarrelsThe GodfatherThursday Movie PicksTMP Thursday Movie Picks: Cannes Favourites Thursday Movie Picks: Farm Thursday Movie Picks: Parenthood I’ve seen all three and The Godfather is the best by far though Lock, Stock was an entertaining film. I wanted to like Goodfellas but I just couldn’t embrace as most other people do. As far as the other Godfather movies go the second one is an essential equal to the first but the final one while not a disaster is a disappointment. I’m a big fan of gangster films but there are so many I went with one of the ultimate gangster stars-James Cagney-to narrow down the choices. The Public Enemy (1931)-Tom Powers (Cagney-in the role that made him a major star) is a small-time hood, vicious and consciousless who climbs to success on the back of Prohibition and his willingness to do whatever necessary-rob, maim, kill-to gain advantage. The film chronicles that rise, and fall, as well as his entanglement with two women Gwen (Jean Harlow, this was one of her earliest appearances, don’t judge her on it-she’s awful-look to her MGM comedies where she’s great) and Kitty (Mae Clarke) who famously receives a grapefruit in her kisser when she mouths off to Cagney. This William Wellman directed picture is one of the formative films in creating the gangster drama. The Roaring Twenties (1939)-Eddie Bartlett (Cagney), George Hally (Humphrey Bogart) and Lloyd Hart (Jeffrey Lynn) strike up a friendship in a foxhole during WWI. Once back in the States they go their separate ways but eventually circumstances bring them back together in the bootlegging business where they find enormous success until jealousies, rivalries and the stock market crash brings it all tumbling down. One of the last great gangster films of the 30’s with a fantastic cast including Priscilla Lane and a scene stealing Gladys George as the lovelorn songbird Panama Smith who delivers the film’s iconic last line. Kiss Tomorrow Goodbye (1950)-Amoral gangster Ralph Cotter (Cagney) breaks out of prison along with fellow prisoner Carleton (Neville Brand). When Carlton is injured Cotter murders him to speed his escape and jumps right back into crime blackmailing Carleton’s sister Holiday (Barbara Payton) into a relationship to conceal her part in aiding their jailbreak. Discovering graft Cotter pressures a couple of crooked cops (Barton MacLane and Ward Bond) and an equally corrupt lawyer (Luther Adler) into a scheme to bilk heiress Margaret Dobson (Helena Carter) out of a fortune. Things do not go as planned. This was the highpoint of leading lady Barbara Payton’s career. A beautiful if somewhat hard looking blonde at this time she was considered a rising star but after a scandal plagued and notorious career she fell as far as it’s possible to go ending up a drug addicted skid row hooker (once being mistaken for a pile of garbage after being left next to a dumpster following a beating) before her death from organ failure at 39. I think I liked Goodfellas more than you did but that’s because I felt more at ease with it. And no surprise there, but I haven’t even heard of two of your picks.. I mean, I’m really a novice when it comes to classic gangster films. I really wish Statham workeed with Ritchie again I wish Ritchie ditched the CGI stuff and just went back to his basics! Sonia (A Film A Day) I haven’t seen your first pick but I loved the other two. I recommend the first! I have the Godfather trilogy and Goodfellas on my 2019 Blind Spot list lol. I’m bad at these classics. What? And I thought I was doing poorly! 😀	cc/2021-04/en_middle_0036.json.gz/line936
__label__wiki	0.607958	0.607958	Effort that takes direct aim 4 the competition He got the rawest cosmic deal of his generation. Alan Pulido 15. We may investigate and work with law enforcement authorities to prosecute users who violate the Terms. There’s one huge superstar that make your own jersey signed anywhere yet. Sam Darnold would not generate big return in a trade? The deal isn’t official, but sources say a deal is in place and the two teams have a verbal agreement. You may use the Service only if you can form a binding contract with the Site, and only in compliance with this Agreement and all applicable local, state, national, and international laws, rules and regulations. C’est la volonté expresse des parties que la présente convention ainsi que tous les documents y afférents soient rédigés en anglais. Like Granlund, he was assigned to the Condors right after Christmas. Clippers L.A. Other elements of the pact include Esurance Rising Star Students, with support from MiLB charity partner Big Brothers Big Sisters of America; Esurance September Call-Ups, leading up to MLB’s postseason; and the Esurance Home Field Advantage Award, recognizing the MiLB club with the highest percentage capacity in each of its 14 leagues. He assisted on 14% of Maccabi’s scores when he was on the floor last season, with a 1 assist-to-turnover ratio. For the next few weeks, we’ll be taking regular looks at the top free agents,… Everyone who was at the Training Camp practice on Friday saw it, too. According to Jennifer Murillo, vp-brand communications for Discover, The NHL is a great partner that allows us to reach our customers. General manager Ron Francis recently said in an interview with The Athletic that he is no rush to name a… Underwear commercials. The percentages next to each loyalty driver indicates the impact each has when Brand Keys compiles its fan loyalty and league engagement factors: • History and Tradition : Are the game and the league part of fans’ and community rituals, institutions, and ‘tribal’ beliefs? Lucas custom baseball jerseys 24. Now, Kumho Tire USA is seeking to leave its own mark on the sports marketing road with deals that include two of the highest profile teams in the NBA, college football and international soccer, including one of the most storied teams in the history of the sport. We look forward to Burger King brand’s participation in our corporate partner family and its commitment to education and college athletics. We joke around. Adidas is an official partner with the FIFA World Cup this summer and will have global marketing and activation. Was that deflating? According to Cheng, We chose to partner with the Golden State Warriors as a way to reach new audiences and fans coast to coast in a way that allows consumers to get to know and experience the ZTE brand as we continue to grow in the United States. We actively look for partners and content that represent all points of view, to keep our readers informed. Kam Canaday injured a knee; and Chris Wormley injured a shoulder. It used to be fun. ← Whose last win stage growth PGA tour was winter Also please offense was working on service red →	cc/2021-04/en_middle_0036.json.gz/line937
__label__cc	0.740366	0.259634	Clare O’Farrell How to cite blogs Translation notes Reading group, Brisbane Foucault News News and resources on French thinker Michel Foucault (1926-1984) Art and craft: Sinquefield Prize winner combines history with theory and simplicity (2018) Clare O'Farrell Art and craft: Sinquefield Prize winner combines history with theory and simplicity By Elena K. Cruz, Columbia Daily Tribune Posted Dec 21, 2018 […] Schroeder won for his composition “genealogy I.” Although he has a history with rock ‘n’ roll, the piece’s restraint made it stand out, said Jacob Gotlib, Mizzou New Music managing director … Categories: Music• Prince’s Sign O’ The Times: celebrating 30 years of genius (2017) Prince’s Sign O’ The Times: celebrating 30 years of genius \| British GQ BY GEORGE CHESTERTON, 07 Aug 2017 Thirty years ago, Prince released his ninth album, a collection of extraordinary songs that became the greatest record of its generation. The pop prodigy’s postmodern magnum opus obsessed with sex, death and faith remains a milestone … Categories: Music, Reviews• Demonstrating Politics Through Music (2017) Connor Richards: Demonstrating Politics Through Music – Daily Utah Chronicle, November 17, 2017 Extract The tradition of using music to make social commentary is being kept alive by American post-metal band ISIS. Post-metal, as a genre, is described by ISIS frontman and lyricist Aaron Turner as being a “thinking man’s metal.” The 2004 album Panopticon … Categories: Magazine articles, Music• Como Tapes (2018) Como Tapes is a non-profit public press based in Burlington, VT and Cherry Hill, NJ trying to put out strange music and other songs in a freeing way on cassettes. From their Manifesto… more thoughts re: Como Tapes updated sept. 2015 Okay, so… last time we spoke (see below) I described the DIY tape label … From the House of the Dead review – formidable performances humanise Janáček’s vision of hell \| Music \| The Guardian (2018) From the House of the Dead review – formidable performances humanise Janáček’s vision of hell \| Music \| The Guardian Tim Ashley Fri 9 Mar 2018 From the House of the Dead is at the Royal Opera House, London, until 24 March. Box office: 020-7304 4000. Krzysztof Warlikowski’s new Royal Opera staging of Janáček’s From the … Categories: Music, Performance• Archive: Diff’rent Level : Governmentality Blues (1992) Diff’rent Level : Governmentality Blues – Written by Alexander Martin. From circa 1992. Posted Nov 10 2016 Categories: Music, Video and audio• Power Is Everywhere songs on texts by Foucault by Kurt Rohde (2017) Power Is Everywhere songs on texts by Foucault by Kurt Rohde Left Coast Chamber Ensemble Presents Francophilia Tuesday, May 30 2017, 7:30-9:30pm \| 50 Oak St Hayes Valley, San Francisco […] Complementing its foray into the French sound, Left Coast is proud to present the world premiere of Power Is Everywhere songs on texts by … Modern Dystopia: Schooltree shake up the rock opera with ‘Heterotopia’ (2017) Victoria Wasylak, Our Modern Dystopia: Schooltree shake up the rock opera with ‘Heterotopia’, Vanyaland: Music and Beyond, March 29, 2017 Somewhere over time, in between spoken lore and salty Facebook statuses, the rock opera was the en vogue way to recount epic stories. While the trend might have seen its peak of popularity around The … Rebel, Rebel? Revisiting the radical legacy of Michel Foucault via David Bowie (2106) Mitchell Dean, Rebel, Rebel? Revisiting the radical legacy of Michel Foucault via David Bowie, Stanford University Press blog, 19 Feb 2016 In order to understand any major thinker and their legacy, it is important to consider their context—a truism that is very hard to put into practice, especially when the thinker in question belongs both … Categories: Music, Online articles, Online commentary• Arkitect \| Foucault’s Dream (music) Heterotopia Remixes Vol. 2 Astral Plane Recordings . Play list Music available on site 1.Jacques Gaspard Biberkopf — Public Love (Air Max ’97 Bootleg)04:22 2.Kid Antoine — Nightvision (Mike G Remix)05:13 3.Rushmore — Moment X (Victoria Kim’s Kowloon Edit)03:48 4.Celestial Trax — Illuminate (Iglew Remix)05:01 5.Victoria Kim — Apgu Freeway (Rushmore Remix)04:11 6.Arkitect — Foucault’s … Send me news Send me news for this blog Open access tools Open DOAR List of OA journals Scribd (paid) Unpaywall Free Full PDF Australasian Open Access Repositories ScholarlyHub Archives Select Month January 2021 (25) December 2020 (35) November 2020 (20) October 2020 (23) September 2020 (22) August 2020 (21) July 2020 (29) June 2020 (37) May 2020 (34) April 2020 (26) March 2020 (31) February 2020 (42) January 2020 (30) December 2019 (33) November 2019 (29) October 2019 (27) September 2019 (26) August 2019 (28) July 2019 (26) June 2019 (20) May 2019 (27) April 2019 (30) March 2019 (34) February 2019 (25) January 2019 (21) December 2018 (27) November 2018 (23) October 2018 (24) September 2018 (28) August 2018 (32) July 2018 (32) June 2018 (33) May 2018 (41) April 2018 (41) March 2018 (38) February 2018 (20) January 2018 (21) December 2017 (11) November 2017 (21) October 2017 (46) September 2017 (26) August 2017 (29) July 2017 (14) June 2017 (14) May 2017 (29) April 2017 (26) March 2017 (36) February 2017 (50) January 2017 (16) December 2016 (26) November 2016 (24) October 2016 (33) September 2016 (32) August 2016 (35) July 2016 (28) June 2016 (22) May 2016 (35) April 2016 (35) March 2016 (35) February 2016 (31) January 2016 (32) December 2015 (31) November 2015 (34) October 2015 (31) September 2015 (34) August 2015 (24) July 2015 (32) June 2015 (32) May 2015 (33) April 2015 (29) March 2015 (27) February 2015 (29) January 2015 (34) December 2014 (33) November 2014 (33) October 2014 (26) September 2014 (32) August 2014 (32) July 2014 (31) June 2014 (31) May 2014 (33) April 2014 (31) March 2014 (34) February 2014 (29) January 2014 (34) December 2013 (33) November 2013 (29) October 2013 (30) September 2013 (32) August 2013 (32) July 2013 (32) June 2013 (32) May 2013 (33) April 2013 (26) March 2013 (30) February 2013 (27) January 2013 (27) December 2012 (24) November 2012 (28) October 2012 (27) September 2012 (25) August 2012 (18) July 2012 (15) June 2012 (24) May 2012 (20) April 2012 (16) March 2012 (18) February 2012 (17) January 2012 (21) December 2011 (19) November 2011 (16) October 2011 (18) September 2011 (17) August 2011 (9) July 2011 (12) June 2011 (15) May 2011 (16) April 2011 (16) March 2011 (17) February 2011 (18) January 2011 (16) December 2010 (13) November 2010 (19) October 2010 (18) September 2010 (27) Art and illustration (91) Bibliographies (10) Book launches (9) Call for book proposals (1) Calls for chapters (13) Calls for papers (125) Colloquia (24) Controversies (11) Doctoral and postgrad schools (12) Employment opportunities (7) Encyclopedia entries (9) Essay review (9) Foucault archives (12) Foucault News exclusive (7) Foucault photographs (2) Foucault quotes (16) Foucault's callaborators (1) Fun, games and toys (13) Grants and Scholarships (4) Handbook entries (1) Journal articles (1,356) Keynote lectures (6) Links of interest (2) Magazine articles (36) Neoliberalism (218) New book series (2) New magazines and journals (2) Newspaper articles (29) Online articles (127) Online commentary (143) online networks (2) PhD programs (1) Photos of Foucault (4) Post-Docs (1) Public lectures (40) Radio programs (5) Requests for information (2) Roundtable (19) Seminar series (36) Special Issues (121) Stuart Elden reblogs (2) Symposia (13) Theoretical puppets (12) Theses and dissertations (12) Thesis oral (1) University news (13) Video and audio (250) Websites and blogs (18) Work by Foucault (139) Working papers (1) z-blog management (18) Foucault: philosophy, spirituality and truth 12 Monkeys (the TV series) and philosophical science fiction A la dérive in the landscape Follow Foucault News	cc/2021-04/en_middle_0036.json.gz/line939
__label__cc	0.728221	0.271779	Physician Training Pediatric Research Centers Children's Health Services Research Developmental Pediatrics General and Community Pediatrics Neonatal Perinatal Medicine Pediatric Critical Care Pediatric Hematology/Oncology Pediatric Palliative Care Pediatric Pulmonology, Allergy and Sleep Medicine Pediatrics Categorical Pediatric Residency FAQ Frequently Asked Questions about Pediatric Residency How are the teams structured? Riley Hospital has two general pediatric hospitalist teams, along with a variety of subspecialty-focused teams. Teams vary in size and structure by service from larger teams (such as Pulmonary and Heme-Onc) where 4-5 interns/residents provide care for 20-25 patients. Other specialties such as Endo, GI, ID, Renal, etc. have smaller teams of 2-3 residents who care for inpatients while also providing consultations. On-call teams are combined from different specialty services, with effort made to keep continuity with a resident’s assigned team patients. How diverse is the residency program? We attract outstanding students from around the U.S. and international schools. Our current residents come from medical schools in 25 states. In addition, IU School of Medicine is the largest medical school in the United States, and we have a small but strong core of our top IU School of Medicine students who go into pediatrics. In addition we select a few outstanding international medical graduates, many of whom have gone on to become Chief residents and top fellows. We usually have a few osteopathic-trained residents and MD/PhDs in each class. As with most pediatric programs, about 75 percent of our residents are women. Those who are married represent 30-50 percent, and some have families. We have several couples in the program and work hard to coordinate scheduling for them. Our diversity reflects most pediatric numbers with a growing number of African-American, Latino and under-represented minority residents in the program. We have many faculty and residents who are part of the LGBTQ community and actively support making our program welcoming to all. How frequent is intern call? Most inpatient rotations for interns are q5 ‘short calls’, assisting with admissions in the late afternoon/evening. This ends at 9 pm so interns can have time at home and not miss out on daily rounds and conferences. Intern electives have weeks without call and a few back-up / jeopardy calls. We do expose interns to some night call experiences as well— PGY1s have a total of four weeks of night float, divided into two blocks. Interns also have some night calls while covering rotations like Hem-Onc, NICU and normal newborn. We strike a good balance in support for time off and rest, while preparing interns for admissions, deliveries, and events that are unique to nights and call. Our overall call schedule is comparable to most large academic centers; call is an important time to learn, to develop independent decision-making, and to participate in deliveries and procedures. We have resident teams on call who work together and 24/7 in-house faculty support for teaching and assistance. How many electives do I get? Two as a PGY1, two as a PGY2, and three as a PGY3. These seven months are for you to tailor to your individual needs. Faculty advisors and program directors help residents design their experiences to explore careers options, evaluate fellowship interests and/or get involved in projects to expand their future career plans. We are committed to being creative, flexible and supportive so you get what you need for your individual path. How much time will I spend at each of the three hospitals? Approximately 75 percent of core rotations are at Riley Hospital for Children, which is the main central campus base for the residency program. To add experience with the underserved and other unique populations, residents spend 1-2 months at Eskenazi Hospital and 2-3 months at Methodist Hospital. These hospitals are both downtown Indianapolis on the same central campus. Finally, we believe in individualizing the curriculum by resident’s goals, so those interested in primary care have some additional selective opportunities in community clinics, the suburban IU North hospital, and Bloomington outpatient experience. Others may choose more specialty care sites, research, global health settings, or community experiences. How much vacation do I get? We appreciate the hard work done by our residents and therefore provide ample vacation opportunities. PGY1s and 2s have three weeks of vacation, while PGY3+s have four weeks. Additionally, all residents have a five-day holiday block over Christmas or New Year’s holidays. PGY1s start their intern year one week early to assist with transition into residency, and therefore get an extra week of vacation between the PGY1 and PGY2 years. What are the IU Boards ABP pass rates? The IU School of Medicine Pediatric Residency program has excellent ABP Board pass rates that are well above the national average. The three-year average is over 90 percent. What do you look for in a resident? Acceptance at Indiana University School of Medicine for residency is highly competitive because of our excellent programs, location and benefits. Applicants should be a good fit for a large program. Attributes include independence, confidence and energized by many different opportunities. We look for: Commitment to patients and serving others Hard-working with a sense of duty/responsibility Active learners who thrive by doing and getting involved High personal expectations with a drive to improve Caring and respectful of others What is it like being part of a big residency program? The intern class size, with 25 categorical residents, is a large program but has a personalized feel with individualized experiences, personal connections and meaningful mentorships. Among the many benefits of a large program include scheduling, call trades, leave switches, vacations and more. The IU School of Medicine residency programs in pediatrics also provides a diverse social network with frequent resident outings. Because Riley is the only children’s comprehensive care hospital in Indiana, residents receive training in a wide range of pediatric problems. For most residents, this is the ideal way to learn and thrive. Our residents are independent self-starters, are adaptive to different settings, and agree that they develop and master skills faster in a system of active learning and diverse experiences. What is the patient population like? IU School of Medicine pediatric residents are exposed to a very diverse patient population in Indianapolis. We have one of the largest urban African-American populations in the U.S. The growing Latino population is a major part of most Eskenazi clinics, and one continuity clinic is housed at a fully bilingual office. Referral patients from around Indiana include rural patients and a large Amish population. There are several immigrant groups from Africa, Asia, Eastern Europe, and a large Burmese population as well. Our patients vary from those that are well-educated and well-informed to uninsured low-income patients. Residents here see all types of patients—from the common to the rare and from a variety of cultures and backgrounds. Advocacy and Community Leadership Global Health Track Current Pediatrics Residents Residency Alumni Application and Interview Process Internal Medicine Pediatrics Program Director Welcome Program Leadership Department Chairs Welcome Neurodevelopmental Disabilities Residency Emergency Medicine Pediatrics Triple Board: Pediatrics/Psych Peds MOC Participant FAQ Project Leaders FAQ IU School of Medicine Department of Pediatrics 705 Riley Hospital Drive Riley Hospital 5900 Indianapolis, IN 46202	cc/2021-04/en_middle_0036.json.gz/line942
__label__wiki	0.50544	0.50544	A kid's guide to chemistry http://science.sciencemag.org/content/350/6266/1322.summary The classic chemistry set gets a 21st-century upgrade A Modern Spin On The Chemistry Set http://www.wbur.org/hereandnow/2015/12/03/modern-chemistry-set Enter sugar snake: Hands-on with MEL Science’s next-gen chemistry kit http://thenextweb.com/gadgets/2015/10/24/enter-sugar-snake-hands-mel-sciences-chemistry-kit/ The VR mode seems especially awesome Educational Experiments Delivered Monthly https://www.hostingadvice.com/blog/mel-science-delivers-educational-experiments/ MEL Science’s Subscription Boxes Turn Your Home into a Chemistry Lab That’s Safe for Kids The Everything Simulator https://medium.com/@amitt/the-everything-simulator-4716c5ad974b MEL Science is using VR to simulate chemical reactions as accurately as possible VR Chemistry Lessons with MEL Science App http://www.techagekids.com/2017/06/vr-chemistry-lessons-with-mel-science.html A brilliant way to help understand complex concepts and inspire more kids to study science Tech me out: Cutting edge tech entering the toy space http://www.toynews-online.biz/opinion/read/tech-me-out-cutting-edge-tech-entering-the-toy-space/048787 Kids are now able to engage with science in a way that they simply wouldn’t have been able to in the past as they shrink themselves down to see the world at a molecular level Special Delivery: Chemistry Sets http://electronics360.globalspec.com/article/9181/special-delivery-chemistry-sets If I could just find a place to order a time machine to bring me back to childhood... Our Favorite Science Kits For Kids http://themomedit.com/2017/12/our-favorite-science-kits-for-kids/ Best Subscription Box For the Serious Chemist These Hands-On Learning Startups Want Your Kid To Be The Next Zuckerberg https://www.forbes.com/sites/tompopomaronis/2017/08/31/these-hands-on-learning-startups-want-your-kid-to-be-the-next-zuckerberg/#3541568663ac The experience is as much social as it is sensory. That adds an element of memorability to what is going on The subscription science company, MEL Science, secures funding https://knowtechie.com/the-subscription-science-company-mel-science-secures-funding/ Science experiments in a never before seen light MEL Science Bolsters Their VR/AR Learning Tool With $2.5 Million https://uploadvr.com/mel-science-investment/ Taking education to the next level MEL Science Raises $2.5 Million to Make Lab Experiments a (Virtual) Reality https://www.edsurge.com/news/2016-10-14-mel-science-raises-2-5-million-to-make-lab-experiments-a-virtual-reality What the Museum at CHF should soon add to its collection are the MEL Science chemistry sets that feature virtual reality technology MEL Science Raises $2.5 Million Series A to Make Learning Fun https://tech.co/mel-science-funding-learning-fun-2016-10 MEL Science is the first to incorporate VR and AR into a single lesson MEL Science Chalks Up $2.5M To Bring Virtual Reality to Education https://www.wsj.com/articles/mel-science-chalks-up-2-5m-to-bring-virtual-reality-to-education-1476271802 MEL Science is to bring virtual reality to education MEL Science raises $2.5 million to put a VR twist on chemistry sets https://techcrunch.com/2016/10/12/mel-science-raises-2-5-million-to-put-a-vr-twist-on-chemistry-sets/ A high-tech twist on the old chemistry sets Get science delivered directly to your door with MEL Chemistry https://knowtechie.com/get-science-delivered-directly-door-mel-chemistry/ Spark an interest in science in a way text books and lectures can never do Get Science Delivered to Your Door with MEL Chemistry https://tech.co/get-science-delivered-door-mel-chemistry-2016-06 Put you or your kid on the path to a Nobel award Cool Vendors in Education, 2016 https://www.gartner.com/doc/3284619/cool-vendors-education- Greatly improves the understanding of chemistry How Technology Has Made Our Kids Smarter Than Ever http://www.huffingtonpost.com/aj-agrawal/how-technology-has-made-o_b_10577380.html MEL Science has seen a huge amount of uptake in their chemistry sets because everything is about grabbing the attentions of young people and keeping them engaged. Product review: MEL Chemistry http://www.theoldschoolhouse.com/product-reviews/?rid=5650 I am thrilled with this program. Thrilled. It Ain't Rocket Science, Episode 42 http://www.connectamillionminds.com/campaigns/itaintrocketscience/episode/42 MEL Chemistry will send you everything you need to turn your home into a laboratory. GeekMom Holiday Gift Guide #4: Toys and Lego! https://geekdad.com/2015/11/geekmom-holiday-gift-guide-4-toys-and-lego/ I’ve noticed over the years that the good old-fashioned chemistry set is tough to come by these days. But MEL Chemistry makes it a reality again with their Chemistry Set subscription boxes. Hands-on Chemistry Comes Home http://www.theedadvocate.org/hands-on-chemistry-comes-home/ I actually walked away with a greater understanding of chemistry than I had before What Modern Parents Want from the Toy Industry- ChiTAG Crushes It http://www.toysaretools.com/2015/11/what-parents-want-from-the-toy-industry.html We were completely blown away by the quality of their products Best Educational Toys & Games for 7- to 10-Year-Olds https://www.livescience.com/56811-educational-toys-for-elementary-students.html A next-generation series of chemistry experiments Subscription Box Chemistry Set http://www.science20.com/square_root_of_not/subscription_box_chemistry_set-158107 A kit that teaches science to kids Cannabis Tester, New Chemistry Set, Old Chemistry Set http://cen.acs.org/articles/93/i45/Cannabis-Tester-New-Chemistry-Set.html While the real-time experiments should satisfy the pyromaniac in every child, MEL’s apps for the iPad, the iPhone, and Android smartphones and tablets should distract kids from game consoles and idle text chatter. MEL Chemistry sets https://www.chemistryworld.com/review/mel-chemistry-sets/9245.article This is one of the most exciting and ambitious home-chemistry educational projects I’ve seen. Last-minute chemistry gifts for the scientist in your life https://www.theguardian.com/science/2015/dec/21/last-minute-chemistry-gifts-for-the-scientist-in-your-life Brings the chemistry set smack up to date... real chemistry in action. A modern twist to that old fashioned chemistry set http://www.newsworks.org/index.php/local/item/88229-a-modern-twist-to-that-old-fashioned-chemistry-set The best tech toys of London Toy Fair 2016 http://www.wired.co.uk/article/top-tech-toys-london-toy-fair-2016 Playing to spectacle — as evidenced by the repeated oohs and ahhs of children we saw using it MEL Chemistry – Perhaps the coolest present to your kids https://www.androidapps.com/mel-chemistry-perhaps-the-coolest-present-to-your-kids/ Mel Chemistry is a good choice for anyone who would like to give an active learning experience for their kids.	cc/2021-04/en_middle_0036.json.gz/line948
__label__wiki	0.679768	0.679768	A’s lose Josh Reddick to knee injury, activate Ryan Cook By Aaron GleemanJun 3, 2014, 1:20 PM EDT A’s outfielder Josh Reddick exited Saturday’s game after hyperextending his left knee and now he’s headed to the the disabled list. Reddick has struggled mightily since a breakout 2012 season, hitting just .222 with 16 homers and a .666 OPS in 164 games, so the A’s won’t exactly miss his production in the lineup. Craig Gentry will likely see extended action in the outfield with Reddick out and the injury could also mean more playing time for recent trade pickup Kyle Blanks. In a corresponding roster move the A’s have activated reliever Ryan Cook from the disabled list after the right-hander missed the past month with a strained forearm. Cook isn’t a big name because he hasn’t been given a chance to rack up saves yet, but he’s been one of the best relievers in the league since debuting for the A’s in 2012.	cc/2021-04/en_middle_0036.json.gz/line953
__label__cc	0.725528	0.274472	Author: Marie Gregg The Wednesday Writers 31 Days of Feasting on Theology Miniseries: Small Groups The LORD Your God in Your Midst 31 Days of Cheering Them On Wolves in Shepherd’s Clothing 31 Days for the Ladies Not the Fundamentals The Detox Diaries 31 Days with the Savior 31 Days of Brave The God with Whom we are Uncomfortable Sola What? 31 Days in the Quiet How I Came to Faith What Depression Means to Me United Kingdom Trip Walking the Road of Faith Review: Wildflower Posted on March 28, 2016 July 12, 2017 by Marie Gentle Reader, A few weeks ago a representative from Faith Street Films contacted me. Would I be interested in receiving an advance copy of their new movie Wildflower in exchange for an honest review? I’d never heard of Faith Street Films. Never head of Wildflower. Still have no idea how or why I was selected for the blog tour. But hey, why not? I’m not one to turn down free books or movies that look worthwhile. The synopsis intrigued me: Creatively gifted, college student Chloe Moray finds solace from a difficult childhood in her extraordinary art. But when an alarming dream begins to recur nightly, Chloe starts to believe that it might be a suppressed memory and that she may have witnessed a terrible crime as a little girl. Her search for peace takes her on a journey that forces Chloe to confront her past traumas and leads her to cross paths with Josh, a young man dealing with his own painful loss. Together they find in each other someone they can trust as they seek to unlock a cold-case mystery from years before. But with the authorities blocking the way, Chloe’s new-found hope is challenged in this powerful story of faith, triumph and healing. If you’ve ever struggled in the aftermath of a difficult situation; if you’ve ever wondered if someone (anyone) will listen to you; if you’ve ever wished there was a safe place you could go, WILDFLOWER is a powerful reminder that hope can be found even in your darkest moments. I had the chance to sit down and watch the movie this morning. The opening scene features Chloe sitting contemplatively at her easel in a college art studio, dabbing bits of color here and there on a large canvas. Something I noticed immediately: The piece, while lovely and certainly far better than I could ever create, wasn’t exactly “extraordinary.” This continued to hit me throughout the film, especially as it was stressed over and over again that this is a very gifted woman. The pieces shown just didn’t strike quite the right note. This, I think, comes down to a mixed characterization. Chloe is meant to be extremely bright and emotionally tormented, yet comes across as flat instead of intense in many scenes. That emotional flatness, stemming from blocked memories, is appropriate to the story, and so it would have been more in line to have the character struggling to produce anything at all, instead of the dozens of drawings and the couple of paintings we see. A blocked artist would have made more sense that one in a frenzy. The plot moves along at a brisk pace. Chloe has long suffered what she terms “blackouts,” which are really symptoms of post-traumatic stress. The episodes have increased in frequency and severity. She lands in the hospital one night after nearly being ran over while standing in the middle of a dark street. The driver of the vehicle is a man named Josh, who is busy fighting his own demons. After suffering a devastating loss while working with a missions group overseas, he has returned home, without purpose and short on faith. His brother Mark, a pastor of a small church, attempts to get him to open up but is met with steely resistance. Josh is determined to deal with his situation in his own time and way. The similarities between Chloe and Josh are a strong point of the movie. It’s interesting to watch as they travel parallel paths. At the same time, I had trouble buying into their near-immediate friendship. (Kudos to the writer and director, Nicholas Dibella, for resisting the temptation to plunge them headlong into a romance). It just doesn’t add up that Chloe, who states over and over again that she has trouble trusting people (with good reason), would bring Josh into her inner torment. Nor does it add up that Josh would feel so compelled to help her. This facet of the film would have worked better with a slight tweak: If Chloe and Josh had known each other, even casually, before the night on the dark road. Chloe slowly comes to understand that the “blackouts” are triggered by a repressed memory. She and Josh work together to uncover the truth, much to the annoyance of local police. Chloe’s mother, with whom she has a broken relationship, worries that her daughter is losing her mind, and there are moments when the audience wonders this as well. By the end of the speedy 92 minutes, everyone knows what really happened, but there are no neat bows. Chloe is not magically fine. Josh is not through with grieving. Neither of them are sliding down rainbows on the backs of fluffy ponies. Wildflower gets points for that. I appreciate the very real take on the messiness of faith. Josh is a believer who wonders if God really is good. Chloe doesn’t know if she believes in God at all. There is no tidy resolution to their questions, though the audience is left with hope that both with find happy endings. This movie takes a stab at dealing with issues that many faith-based projects avoid or sugarcoat: Mental illness, sexual molestation, murder, drug and alcohol abuse and single-parent homes. While the scenes of violence are far from graphic, they are real and sobering. There’s no pretending that conversion suddenly makes everything rosy. Despite issues of character and plot, all told it was a decent hour-and-a-half. Tagged Movies, Review, Wildflower Previous Post Five Minute Friday: Alive Next Post Five Minute Friday: Decide 2 thoughts on “Review: Wildflower” Aunt Lenore says: I can’t think of anyone better than you to review a movie, especially with what you wrote here. I would love to watch it – any idea when it will be available? I struggle to find “decent” movies to watch and then get so caught up in life that I forget to rent any! Would love to know if what you wrote IS your review of this movie! The movie will be released directly to dvd on April 5. You can purchase it on Amazon. 🙂 ©Marie Gregg, 2021 Unauthorized use and/or duplication of this material without express and written permission from this site’s author/owner is prohibited. Excerpts and links may be used, provided that full and clear credit is given, with appropriate and specific direction to the original content.	cc/2021-04/en_middle_0036.json.gz/line954
__label__wiki	0.844655	0.844655	Farm. Food. Life. Million Gardens Movement MTMF Urban Permaculture Explore the Modern Farmers' Market » Farm Notebooks Stay Home, Plant a Garden, Support a charity. NEW "Home Grown" Tees Immigrants Feed America Food & Drink, Plants By Lindsay Campbell on August 3, 2020 Lindsay Campbell How COVID-19 could result in a new generation of foragers. Violet Brill was exposed to foraging and wild plants by her father, Steve. Photography courtesy of Violet Brill. Violet Brill looks at a forest the same way most people think about a supermarket. Walk through a park or wooded area with the 16-year-old and she can show you a number of wild plants that might make for tasty additions to your dinner plate. She would tell you how yellow wood sorrel tastes just like lemonade or how black birch can be used as a minty flavoring for pudding. She might even share that hickory nuts are one of her favorite snacks. Brill, the daughter of New Rochelle, New York-based foraging expert Steve “Wildman” Brill, has been immersed in the world of wild foods since she was born. She started accompanying her father on his food foraging tours when she was just two months old. Now she hosts them on her own. Armed with an encyclopaedic knowledge of her local terroir, Brill considers herself an anomaly. She knows most young people aren’t as resourceful and haven’t been raised to recognize the foods that grow right in their backyard, but she wishes they were. “Foraging has made me appreciate where our food comes from,” she says. “Kids, if they’re engaged with this stuff, they’ll have a general love for the planet like I do… A lot of people aren’t respecting the natural world around them and it’s leading to further problems.” While she might be an exceptional case for a teenager right now, Brill’s experiences may become a lot more common for the next generation. Expert foragers who host educational experiences across the country have seen high demand for their services among parents with children during the pandemic. As the conversation continues on whether and how schools will reopen in the fall, some parents hesitant to send their kids back have been exploring a type of learning based on experience, practical skills and a relationship with the land. Dan De Lion, a herbalist, forager and founder of Return to Nature, provides foraging classes in parks and a forested area throughout New Jersey, New York and Pennsylvania. When he resumed his operations in May after lockdowns, he experienced about a 30 percent increase in the number of families taking his courses. He adds that there’s also been a significant uptick in interest for his classes that he offers for children specifically. “This has been the biggest homeschooling experiment in the world,” he says. “People are recognizing how blinded they are to what’s around them…you could do 15 years of school and not one person will ever tell you about a plant that grows outside that you can eat.” If this trend continues, De Lion says it will result in a new crop of humble, self-reliant young people who appreciate living sustainably. There has been huge demand for foraged food boxes during the pandemic. Photo courtesy of Iso Rabins. In northern California, Iso Rabins, the founder of forageSF, has experienced a rush of eager parents looking to connect their children to foraged goods. His business provides classes on mushroom hunting as well as wild plant and seaweed foraging. When stay-at-home orders came down in March, Rabins switched to remote classes and started offering a foraged food box, which is now sold out with a waiting list of more than 500 people. About 60 to 70 percent of his customers have been families and many of them have inquired about private sessions for their kids. Parents unwilling to send their kids back to school that have created homeschooling “pods” have reached out to him about how they can integrate his classes into a home curriculum. “During any time of uncertainty people want a real connection to the place where they are…and a real touchstone is food and foraging and getting out in nature,” he says. “I think this is definitely a new wave of people interested in a different way.” Even those who had homeschooled their kids before the pandemic are choosing to incorporate more education about natural foods, says Steve Brill, Violet Brill’s father. He’s running foraging walks in New York and Connecticut with a group of homeschooled kids every two weeks. Despite the current uncertainty in the world, Violet Brill says the spike in interest around foraging is encouraging. To her, it means the possibility of a greener future with a more informed population that shares her love for the land. Sign up for your Modern Farmer Weekly Newsletter Be Prepared for a Possible Seed ShortageJodi Helmer The Modern Farmer Guide To Buying SeedsLindsay Campbell 7 Smokable Plants You Can Grow That Aren’t MarijuanaBrian Barth 6 Secretly Poisonous Plants We Eat All the TimeDan Nosowitz Could Indoor Vertical Farms Be the Future of Livestock Feed?Lindsay Campbell Explore Modern Farmer Meet the Modern Farmer Nestlé Recalls Pepperoni Hot Pockets After Glass FoundAlex Robinson Animals, Plants Food & Drink, Health Court Orders School Lunch Supplier to Stop Selling ‘Adulterated’ JuiceAlex Robinson Farm Favorites Read the latest reviews on our favorite products. Immigrants Feed America t-shirts are back – find them at the Modern Farmers Market Things We Love: AKUA Kelp Jerky If you told me there was a jerky snack made out of kelp - yes,... (more) Things We Love: CleverMade Snapbasket Cooler It can keep up to 50 cans chilled for up to 36 hours and collapses... (more) Things We Love: Republic of Tea Daily Greens Single Sips It's like green juice: but way easier. © Modern Farmer Media, 2021.	cc/2021-04/en_middle_0036.json.gz/line955
__label__wiki	0.831	0.831	Sample MondayMorning Newsletter January 11, 2016 Humdrum, stodgy Pfizer suddenly turns heads with partial drug-pipeline spinoff; old dog apparently can learn new tricks. Steve Walker September 29, 2017 September 29, 2017 No Comments on Humdrum, stodgy Pfizer suddenly turns heads with partial drug-pipeline spinoff; old dog apparently can learn new tricks. woodsilver / Pixabay The News: Pfizer Inc. (NYC) on Monday (September 25, 2017) announced that it is spinning off a new company, SpringWorks Therapeutics LLC, to develop several drugs for rare diseases that the drug giant did not want to move forward internally. The new firm will be funded with $103 million from Pfizer, Bain Capital Life Sciences, Bain Capital Double Impact, Orbimed and Lifers, according to Forbes. “We’re left with some compounds that we think have great promise for patients but are not necessarily core,” Freda Lewis-Hall, executive vice president and chief medical officer at Pfizer, said. “We originally conceived of this as kind of a new and innovative way for us to advance the investigational therapies that we thought hold significant promise for underserved populations.” Over the past decade, many Pfizer drugs have found success outside the company: Puma Biotechnology Inc. (South San Francisco) boasts a $3.89 billion market capitalization thanks to breast-cancer drug Nerlynx, originally a Pfizer compound. Esperion Therapeutics Inc. (Ann Arbor MI), a developer of heart drugs bought by Pfizer and spun out again, has a $1.27 billion market cap. Durata Therapeutics, bought by Actavis in 2014 for $675 million, was also based upon Pfizer drugs. “Pfizer perhaps has learned from the fact that it’s had a lot of compounds on its shelf that others capitalized on,” says John LaMattina, senior partner at PureTech Ventures and former head of R&D at Pfizer. Pfizer also isn’t the first drug giant to spin out a smaller drug company and collect funds from venture capitalists, Forbes points out. In June, Johnson & Johnson (New Brunswick NJ) did this with a company called Provention Bio, which raised $28.4 million. But the Pfizer deal “is the biggest one of these that we’ve seen,” says David Grainger, partner at Medicxi Ventures (London). SpringWorks founder and president Lara Sullivan and Lewis-Hall worked on the idea for the new company for the past two and a half years, at first after hours from Sullivan’s work as a vice president at Pfizer managing compounds in the research pipeline through Phase 2 trials. The two identified some compounds in the company’s portfolio that showed promise in rare diseases or for underserved patient populations and thought . . . “a more partnered development paradigm and channel would be optimal to help those compounds go forward more quickly,” Sullivan said. New York-based SpringWorks is starting out with four compounds licensed from Pfizer, half of them poised for Phase 3 trials. One of the compounds, the Gardos channel inhibitor senicapoc, previously failed to meet efficacy hurdles in a Phase 3 trial for sickle cell anemia. SpringWorks plans to test senicapoc in hereditary xerocytosis, a rare genetic form of anemia in which red blood cells become dehydrated, causing a range of symptoms including jaundice, tiredness, an enlarged spleen and gallstones. SpringWorks has plans to start Phase 3 trials for nirogacestat, a gamma-secretase inhibitor Pfizer had been developing for breast cancer, in patients with noncancerous connective tissue growths called desmoid tumors. Also ready for Phase 3 is a MEK inhibitor for neurofibromatosis type 1, a genetic disorder in which noncancerous tumors grow next to nerves. SpringWorks’ final compound is a FAAH inhibitor it plans to test in post-traumatic stress disorder. Pfizer was developing the compound for pain when a Phase 1 trial of another FAAH inhibitor from the Portuguese pharma company Bial SA caused brain death in one patient and neurological damage in others. The FDA reviewed data on the FAAH inhibitor SpringWorks now has, Sullivan said, and said they can proceed. Steve’s Take: So you can’t teach an old dog new tricks, eh? Months, or even years, go by where observers like me don’t really pay any attention to the NYC-based pharma goliath. Why? Well, with a mammoth market cap of $210 billion, a beta south of 1.0, 316 consecutive quarterly dividends, an annual dividend of $1.28 (yield of 3.63%) and a 1-year share-price change of a whole +4.71%, what’s to get excited about? Actually, this SpringWorks deal is a hopeful, reassuring sign Pfizer hasn’t lost its sense of adventure into the realm of sound, forward-looking business logic. This isn’t a small experiment, Xconomy points out. Springworks plans to develop not just the four Pfizer drugs–which are all set for either mid- or late-stage clinical trials—but also experimental therapies other pharma companies abandon for one reason or another. The yardstick? SpringWorks favors drugs ready for Phase 2 that it can develop for diseases with either no approved therapies, or “minimal to no competition from others.” Pharma companies scrap development of experimental drugs all the time and Sullivan saw this up close at Pfizer, where she helped decide which early-stage drugs to put resources into, and which to discard or license out to someone else. Two things she and Pfizer chief medical officer Freda Lewis-Hall noticed: More programs were fighting for funding than Pfizer could handle, and outside groups were increasingly interested in snatching up the drugs falling through the cracks. Sullivan says the difference between SpringWorks and other efforts to push forward stalled pharma drugs is both its broad scope and the incentives it will hand to those it does deals with. Those incentives include, potentially, a piece of SpringWorks equity, not just downstream payments, which may help subdue a company’s fear of dumping a program that may later prove very valuable, Sullivan says. “We will have the ability and structure to allow our partners to share in our future success,” Sullivan says. The hope, according to Sullivan, is the startup may eventually provide a “systemic solution” for stalled drug programs at Pfizer and elsewhere. But SpringWorks must chalk up some victories in clinical testing first to prove that. Pfizer’s move to create an independent company–deliberately safety net-free–suggests the biggest wheels of the drug industry have learned an important lesson, said Bernard Munos, a former R&D executive at Eli Lilly who now consults for pharma companies. “I think the industry has realized that they have not really been true to their words in terms of embracing innovation,” Munos said. “So this is very encouraging, frankly, especially coming from Pfizer.” What do the analysts think? As of Sep 22, 2017, the consensus forecast among 22 analysts covering Pfizer advises that the company will Outperform the market. This has been the consensus forecast since the sentiment of investment analysts improved on Dec 03, 2008. The previous consensus forecast advised investors to Hold their position. Share price forecast The 20 analysts offering 12-month price targets for Pfizer have a median target of $37.00, with a high estimate of $54.00 and a low estimate of $31.00. The median estimate represents a 4% increase from the last price of $35.43. Damian Garde at Stat posits the popular theory about the limitations of global pharma companies: “For all their skyscrapers and strategy reviews and private jets, they’re simply too knotted up in bureaucracy to realize how many great drugs are gathering dust in their vaults. Now, the biggest of Big Pharma is out to do something about that.” This may seem odd in that Pfizer spends literally billions of dollars a year advancing treatments of its own. But the company’s executives say they simply don’t have the resources to advance all the promising compounds that catch their eye–and they believe an independent company with the plucky culture of a startup will be in a better position to take on that task. Steve's Take: Springworks spinoff has a lot of upside for @Pfizer with little capital risk Click To Tweet Pfizer is forgoing up-front cash by not licensing these drugs to an unrelated party, but this is a better option, says Max Nisen at Bloomberg. It’s not the best time to get a choice licensing deal; multiple companies are overhauling R&D efforts and selling off drugs. Pfizer will get milestone and royalty payments if the drugs succeed, as it would under a standard licensing agreement. But it gets extra upside through its equity stake in the spinoff. Given the participation of Bain Capital and other investors, Pfizer’s cash outlay probably wasn’t significant. And the company has a chance of a return on drugs that may have otherwise languished on the shelf. This spinoff move has a lot of upside for Pfizer with relatively little capital risk. Most significantly for investors, however, it signals that the old pharma goliath can join in the new strategic thinking about drug development with a solid, 2017-era tactic. Corporate, Pharmaceuticals Actavis PLC, Bain Capital Double Impact, Bain Capital Life Sciences, Bernard Munos, Bloomberg, Damian Garde, David Grainger, Durata Therapeutics, Esperion Therapeutics Inc., Forbes, Freda Lewis-Hall, John LaMattina, Johnson & Johnson, Lara Sullivan, Lifers, Max Nisen, Nerlynx, Nirogacestat, Orbimed, Pfizer Inc., Provention Bio, Puma Biotechnology Inc., Senicapoc, SpringWorks Therapeutics LLC, STAT News, Xconomy Alnylam soars on RNAi success as Phase 3 patisiran study hits all goals; market overreacts as pipeline unproven and competition lurks. Patients lose, lawyers win, as AbbVie does deal with Amgen to delay Humira biosim. Follow @MonMorningNews Tweets by MonMorningNews More MondayMorning Top Stories for Week of January 11, 2021 Top Stories for Week of January 4, 2021 Top Stories for Week of December 21, 2020 Top Stories for Week of December 7, 2020 China records more than 2,000 new coronavirus cases in 24 hours; CDC director says CIVUD-19 probably with us beyond this Top Stories for Week of June 8, 2020 Top Stories for Week of August 10, 2020 Top Stories for Week of October 5, 2020	cc/2021-04/en_middle_0036.json.gz/line957
__label__cc	0.74863	0.25137	April 19, 2020 /in News, Reflections /by Tom Morin Vern Harnish pushed out this motivational article by American tech pioneer and venture capitalist Marc Andreessen over the weekend. I’ve copied it below because it helped me to crystalize the way I feel about the future. The COVID-19 pandemic might have sucker-punched us but it’s given us a once-in-a-lifetime opportunity to alter our course towards a better future. Along with the tragedy it is bringing, the crisis is making it painfully obvious where we have let our guard down. When we dust ourselves off, we will have to choose how we’re going to act, what we’re going to fix, recognize what we cherish and need to improve. Marc argues that for too long we’ve let other people do the hard work for us and that it’s time for us to roll up our sleeves and get busy building the future that we want ourselves. I’m optimistic that we can rally around a shared vision and take the right path. Take 5 minutes to read Marc’s essay: Every Western institution was unprepared for the coronavirus pandemic, despite many prior warnings. This monumental failure of institutional effectiveness will reverberate for the rest of the decade, but it’s not too early to ask why, and what we need to do about it. Many of us would like to pin the cause on one political party or another, on one government or another. But the harsh reality is that it all failed — no Western country, or state, or city was prepared — and despite hard work and often extraordinary sacrifice by many people within these institutions. So the problem runs deeper than your favorite political opponent or your home nation. Part of the problem is clearly foresight, a failure of imagination. But the other part of the problem is what we didn’t do in advance, and what we’re failing to do now. And that is a failure of action, and specifically our widespread inability to build. We see this today with the things we urgently need but don’t have. We don’t have enough coronavirus tests, or test materials — including, amazingly, cotton swabs and common reagents. We don’t have enough ventilators, negative pressure rooms, and ICU beds. And we don’t have enough surgical masks, eye shields, and medical gowns — as I write this, New York City has put out a desperate call for rain ponchos to be used as medical gowns. Rain ponchos! In 2020! In America! We also don’t have therapies or a vaccine — despite, again, years of advance warning about bat-borne coronaviruses. Our scientists will hopefully invent therapies and a vaccine, but then we may not have the manufacturing factories required to scale their production. And even then, we’ll see if we can deploy therapies or a vaccine fast enough to matter — it took scientists 5 years to get regulatory testing approval for the new Ebola vaccine after that scourge’s 2014 outbreak, at the cost of many lives. In the U.S., we don’t even have the ability to get federal bailout money to the people and businesses that need it. Tens of millions of laid-off workers and their families, and many millions of small businesses, are in serious trouble right now, and we have no direct method to transfer them money without potentially disastrous delays. A government that collects money from all its citizens and businesses each year has never built a system to distribute money to us when it’s needed most. Why do we not have these things? Medical equipment and financial conduits involve no rocket science whatsoever. At least therapies and vaccines are hard! Making masks and transferring money are not hard. We could have these things but we chose not to — specifically, we chose not to have the mechanisms, the factories, the systems to make these things. We chose not to build. You don’t just see this smug complacency, this satisfaction with the status quo and the unwillingness to build, in the pandemic, or in healthcare generally. You see it throughout Western life, and specifically throughout American life. You see it in housing and the physical footprint of our cities. We can’t build nearly enough housing in our cities with surging economic potential — which results in crazily skyrocketing housing prices in places like San Francisco, making it nearly impossible for regular people to move in and take the jobs of the future. We also can’t build the cities themselves anymore. When the producers of HBO’s “Westworld” wanted to portray the American city of the future, they didn’t film in Seattle or Los Angeles or Austin — they went to Singapore. We should have gleaming skyscrapers and spectacular living environments in all our best cities at levels way beyond what we have now; where are they? You see it in education. We have top-end universities, yes, but with the capacity to teach only a microscopic percentage of the 4 million new 18-year-olds in the U.S. each year, or the 120 million new 18-year-olds in the world each year. Why not educate every 18-year-old? Isn’t that the most important thing we can possibly do? Why not build a far larger number of universities, or scale the ones we have way up? The last major innovation in K-12 education was Montessori, which traces back to the 1960s; we’ve been doing education research that’s never reached practical deployment for 50 years since; why not build a lot more great K-12 schools using everything we now know? We know one-to-one tutoring can reliably increase education outcomes by two standard deviations (the Bloom two-sigma effect); we have the internet; why haven’t we built systems to match every young learner with an older tutor to dramatically improve student success? You see it in manufacturing. Contrary to conventional wisdom, American manufacturing output is higher than ever, but why has so much manufacturing been offshored to places with cheaper manual labor? We know how to build highly automated factories. We know the enormous number of higher paying jobs we would create to design and build and operate those factories. We know — and we’re experiencing right now! — the strategic problem of relying on offshore manufacturing of key goods. Why aren’t we building Elon Musk’s “alien dreadnoughts” — giant, gleaming, state of the art factories producing every conceivable kind of product, at the highest possible quality and lowest possible cost — all throughout our country? You see it in transportation. Where are the supersonic aircraft? Where are the millions of delivery drones? Where are the high speed trains, the soaring monorails, the hyperloops, and yes, the flying cars? Is the problem money? That seems hard to believe when we have the money to wage endless wars in the Middle East and repeatedly bail out incumbent banks, airlines, and carmakers. The federal government just passed a $2 trillion coronavirus rescue package in two weeks! Is the problem capitalism? I’m with Nicholas Stern when he says that capitalism is how we take care of people we don’t know — all of these fields are highly lucrative already and should be prime stomping grounds for capitalist investment, good both for the investor and the customers who are served. Is the problem technical competence? Clearly not, or we wouldn’t have the homes and skyscrapers, schools and hospitals, cars and trains, computers and smartphones, that we already have. The problem is desire. We need to want these things. The problem is inertia. We need to want these things more than we want to prevent these things. The problem is regulatory capture. We need to want new companies to build these things, even if incumbents don’t like it, even if only to force the incumbents to build these things. And the problem is will. We need to build these things. And we need to separate the imperative to build these things from ideology and politics. Both sides need to contribute to building. The right starts out in a more natural, albeit compromised, place. The right is generally pro production, but is too often corrupted by forces that hold back market-based competition and the building of things. The right must fight hard against crony capitalism, regulatory capture, ossified oligopolies, risk-inducing offshoring, and investor-friendly buybacks in lieu of customer-friendly (and, over a longer period of time, even more investor-friendly) innovation. It’s time for full-throated, unapologetic, uncompromised political support from the right for aggressive investment in new products, in new industries, in new factories, in new science, in big leaps forward. The left starts out with a stronger bias toward the public sector in many of these areas. To which I say, prove the superior model! Demonstrate that the public sector can build better hospitals, better schools, better transportation, better cities, better housing. Stop trying to protect the old, the entrenched, the irrelevant; commit the public sector fully to the future. Milton Friedman once said the great public sector mistake is to judge policies and programs by their intentions rather than their results. Instead of taking that as an insult, take it as a challenge — build new things and show the results! Show that new models of public sector healthcare can be inexpensive and effective — how about starting with the VA? When the next coronavirus comes along, blow us away! Even private universities like Harvard are lavished with public funding; why can’t 100,000 or 1 million students a year attend Harvard? Why shouldn’t regulators and taxpayers demand that Harvard build? Solve the climate crisis by building — energy experts say that all carbon-based electrical power generation on the planet could be replaced by a few thousand new zero-emission nuclear reactors, so let’s build those. Maybe we can start with 10 new reactors? Then 100? Then the rest? In fact, I think building is how we reboot the American dream. The things we build in huge quantities, like computers and TVs, drop rapidly in price. The things we don’t, like housing, schools, and hospitals, skyrocket in price. What’s the American dream? The opportunity to have a home of your own, and a family you can provide for. We need to break the rapidly escalating price curves for housing, education, and healthcare, to make sure that every American can realize the dream, and the only way to do that is to build. Building isn’t easy, or we’d already be doing all this. We need to demand more of our political leaders, of our CEOs, our entrepreneurs, our investors. We need to demand more of our culture, of our society. And we need to demand more from one another. We’re all necessary, and we can all contribute, to building. Every step of the way, to everyone around us, we should be asking the question, what are you building? What are you building directly, or helping other people to build, or teaching other people to build, or taking care of people who are building? If the work you’re doing isn’t either leading to something being built or taking care of people directly, we’ve failed you, and we need to get you into a position, an occupation, a career where you can contribute to building. There are always outstanding people in even the most broken systems — we need to get all the talent we can on the biggest problems we have, and on building the answers to those problems. I expect this essay to be the target of criticism. Here’s a modest proposal to my critics. Instead of attacking my ideas of what to build, conceive your own! What do you think we should build? There’s an excellent chance I’ll agree with you. Our nation and our civilization were built on production, on building. Our forefathers and foremothers built roads and trains, farms and factories, then the computer, the microchip, the smartphone, and uncounted thousands of other things that we now take for granted, that are all around us, that define our lives and provide for our well-being. There is only one way to honor their legacy and to create the future we want for our own children and grandchildren, and that’s to build. https://morinwood.ca/wp-content/uploads/2020/04/buildingfuture.jpg 360 600 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2020-04-19 09:40:422020-04-20 13:26:07IT’S TIME TO BUILD Leading in Tough Times: Wisdom from CEO’s March 22, 2020 /in News, Reflections /by Tom Morin After I saw the ravaged store shelves this weekend, I thought it would be a good time to get some perspective on piloting through choppy waters from local CEO members of The Entrepreneurs Organization. Many of them started tiny businesses that grew into much more serious enterprises and unknowingly committed themselves to quarterback a lot of folks. One recurring theme they brought up is the realization that there is no escaping the obligation to lead, especially when an emergency like the current COVID-19 pandemic is raging. Here is a summary of the sage advice I gathered speaking to some of the city’s top business brains today on how they approach a crisis: -Stay positive. No matter how crazy things are you are still in control of a lot of moving pieces. Fight the urge to be overwhelmed and focus on the positive things you are able to achieve. -You set the tone. The leader’s positive energy will give more comfort and strength to your team than you know. In a crisis, the leader’s every action is noticed and scrutinized. You can make the most of this. -Get the facts. Good decisions come from good data. Take time away to read, listen, talk to colleagues so that your decisions are well informed. -Use your powers of vision. Not everyone is born with the ability to see the future. Many entrepreneurs, however, have this gift. Use it to prepare people for what lies ahead and to set their expectations as to how you will deal with the challenges to come. -Comfort. Listen to everyone’s concerns and validate them, even if you disagree. This lowers anxiety and lets people focus rationally on the tasks at hand, of which there will be many. -Keep some perspective. This is not the first or the last health crisis we’ll have. It will require decisive action over a prolonged period. However, sure as the sun will rise, we will get through it intact. https://morinwood.ca/wp-content/uploads/2020/03/cda-coronavirus-202003066-3-jpg.jpg 553 804 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2020-03-22 01:43:422020-04-20 13:06:36Leading in Tough Times: Wisdom from CEO's Wisdom’s retirement party October 22, 2019 /in News, Reflections /by Tom Morin I like politics, so I stayed up late to watch our youthful federal leaders deliver their post-election speeches. There was a strange chaotic moment when, the Liberals, Conservatives, and NDP all tried to take their respective stages at exactly the same time – perhaps each hoping to drown out the others – forcing the poor CBC anchor to jump feverishly between them. But it was the contents of their speeches that really dismayed me. The NDP crowd burst into an animated chant of TAX THE RICH, TAX THE RICH that the leader encouraged along for two full uncomfortable minutes. Andrew Sheer for his part went on about how his loss was really a win and he was going to beat the encroaching forces of socialism next time. Our prime minister dished his regular pablum and seemed to think that liberal values had triumphed and been embraced by all, when in fact only 32% of our country supported him. What was missing for me, was any recognition that the election is over and it is time to bury the partisanship for a bit and get united on governing the country. We have ample big problems: resource development and Alberta’s place in a new economy, housing the next generation, Indigenous reconciliation, how to pay for our cherished education and healthcare systems, getting citizens to take responsibility for the hot mess we’re making of our planet…to name a few. But our leaders were not talking about solutions for Canada’s problems. They were each preaching to their bases and bashing the other two thirds. The only redeeming moments of the night were the gracious speeches from Conservative Lisa Raitt and Liberal Ralph Goodale – two seasoned and respected parliamentarians who each went down to defeat. They both seemed to come from a more civilized planet than their respective leaders. Godspeed. It made me think about the changes in the construction industry that EllisDon’s Jeff Smith observed in an article recently: our industry is becoming nastier. I agree with Jeff. Over the last couple of years, my company’s jobs have become more about emailing than millwork, more about building arguments than structures, more about protecting interests than getting the work done. Of course, we all have to look out for ourselves in business, but it can’t be the only thing we do. I fear that the old guard that has been retiring over the last few years were the holders of a more balanced common sense. They were leaders who could leverage relationships to get work done without a single trip to their inbox. Their underlying ethic was win-win in spite of whatever crusty exterior they might have presented. It’s funny because when I started in the construction industry I thought this group of gruff, old-school men where the problem (yes, they were all men). In retrospect, in almost every case these gentlemen had an uncanny sense of the best way to get a project to the finish line with all of the players intact. My friends, reflect on this. Is it possible that our industry has become too political, too partisan? Is it possible that our younger generation of project managers is more concerned with winning than with satisfied customers and successful projects? As this industry’s leaders, what can we do to improve this? I’m going to suggest we need to act less like our current political leaders and look to the values of the old guard who are now retiring. Let’s make sure we extract and hang onto their ethic as they take their retirement. We’ll be a poorer industry without their wisdom. https://morinwood.ca/wp-content/uploads/2019/05/Tom1.jpg 2149 1612 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2019-10-22 09:37:352020-08-18 04:42:34Wisdom's retirement party Our MVP Plan June 4, 2019 /in News, Reflections /by Tom Morin I learned why Alan Mulally is such a unique CEO when I heard him speak last October. He changed the way I run my business and inspired me to create our MVP Plan. What makes him unique First off, Mulally is responsible for saving the Ford Motor Company. When Ford was at its lowest point (losing 17 Billion in 2006) he led the company back to profitability. This included weathering the 2008 financial meltdown, that bankrupted GM and Chrysler, without taking any government assistance. Another is his unique style. Mulally describes his leadership as service and combines this with infectious optimism and gracious humility – traits that let him unify a fractious company around a shared mission. He says his leadership values are based on snippets of wisdom his mother ingrained in him such as “It is nice to be important, but more important to be nice.” And “The purpose of life is to love and be loved.” This is not typical thinking from a corporate titan. However, it struck me that his message of collaborative teamwork is the way forward not only for manufacturing but also for our construction industry. The most powerful lesson for me was Mulally’s integrated operational plan that he summed up on a single slide titled: ‘One Ford: one team, one plan, one goal’. It laid out the way Mulally united a complex global corporate culture around a single compelling vision and tied that directly to an operational plan that was tracked with detailed metrics. Mulally famously carried this out at a weekly Business Plan Review meeting (BPR), which he established to track the progress of the One Ford plan with his 16 senior managers. At the Thursday meetings, each director was responsible for reporting on a host of green/amber/red colour coded metrics that tracked their department’s progress against the plan. The focus and accountability that the BPR ultimately created are credited with Ford’s turn around. How he changed my company Understanding this simple, powerful system connected deeply with me. We started building and tweaking our own Business Plan and identifying the right metrics to drive the results we’re looking for. I call the result our ‘Most Valued Partner Plan’ because our Mission is to be just that for our clients – their most valued partner. Internally we now track 37 metrics under the four categories that are critical to our customers’ success: Competent People Obvious Value Flawless Execution I’m already noticing that seeing the data weekly is causing us to uncover longstanding problems and motivating the team to cooperate on eliminating them. Starting next week, we’ll be surveying our customers and our staff and integrating their ratings of our performance into our dashboard. This data will further confirm that we’re ‘on plan’ and show us where to focus our efforts. These are exciting times and I’m grateful to Mr Mulally for showing me the path. Learn more about Mulally’s turnaround in this book by Bryce Hoffman . https://morinwood.ca/wp-content/uploads/2019/06/Ford-CEO.jpg 450 970 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2019-06-04 11:49:342020-04-27 08:27:09Our MVP Plan Watch us get LEAN! April 20, 2019 /in News /by Tom Morin You’d call me a student of Lean because for as long as I’ve been working, I’ve been trying to learn and promote the tenants of Lean Manufacturing. I say student because I’m constantly learning more and even more often being humbled by how much i don’t know. I think my biggest aha moment came […] https://morinwood.ca/wp-content/uploads/2019/04/Lean-Heith.jpg 827 1210 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2019-04-20 20:47:382020-04-27 08:35:04Watch us get LEAN! Apprentice Success! February 1, 2019 /in News, Uncategorised /by Tom Morin Kudos to Mitch Bell who was chosen as the most promising student in his class at BCIT. It’s great to see such keen students entering our trade and investing in an apprenticeship. AWMAC members support these students by contributing to a well-stocked toolbag for the highest achieving students. All the staff at Morinwood wish Mitch continued success in the trade! https://morinwood.ca/wp-content/uploads/2019/02/toolbag-michell-Bell.jpg 3175 2181 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2019-02-01 18:04:442020-04-20 13:02:38Apprentice Success! Resolution Free Zone January 2, 2019 /in News, Reflections /by Tom Morin I’m always searching for better. Better business systems, better health, better time at home… Plus, there is something about this time of year. Maybe it’s watching ‘It’s a Wonderful Life’ yet again, or seeing your in-laws, but I always end up reflecting on the state of the world I’ve built around myself and think about how it could be better. Don’t get me wrong. I’m routinely accused of being a ‘glass overflowing’ kind of guy, but this is the time of year when I look to see if my destination is getting any closer and if it’s time for any course corrections. And so, we come to the inevitable topic of resolutions. I got some great advice from James Clear, author of Atomic Habits. He is an advocate of tiny habits resulting in big goals. James talks about optimizing for the starting line instead of the finish line. For example, instead of aiming to lose 20 pounds, make your goal to just show up at the gym, even if you don’t get out of your car, just make a habit of getting to the gym. Once that becomes a habit, the larger goal will follow. Read the book or watch one of his youtube videos. This is the same message our friend Paul Akers preaches: tiny improvements gradually transform our company and our lives. Like Clear, he’s talking about forming habits. The habit of making daily improvements. So here’s wishing you an Atomic 2019. May your habits make you happy. If you like some inspiration for your lean goals check out this video made at Yellowtools in Germany https://youtu.be/O6R2CmyaMlY. https://morinwood.ca/wp-content/uploads/2019/01/Victoria.jpeg 616 1200 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2019-01-02 13:11:252020-04-20 13:02:56Resolution Free Zone Substantial Completion at Valley View December 21, 2018 /in New Projects, News /by Tom Morin Wayne should really look happier in this photo! We started working with PCL Construction on this design build project in the summer of 2016. The new building on the Riverview Lands in Port Coquitlam will house treatment programs for youth aged 12 to 17. The unique needs of this facility meant a long collaborative process to get all the details right. Ted and his crew have been working on site since May getting the millwork and wall protection scopes installed. https://morinwood.ca/wp-content/uploads/2018/12/Valley-View.jpeg 595 1210 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2018-12-21 18:20:212020-04-20 13:03:13Substantial Completion at Valley View Amazing Calgary Library November 12, 2018 /in News, Unique Buildings /by Tom Morin I don’t remember the last time I was so impressed by a building. The Calgary Central Library website says: “This family destination and gathering place was designed to be a landmark, built to inspire Calgarians for the next 100 years”. That seems spot-on. The building is full of inspiring spaces designed for every civic purpose and community use you could think of. I came away feeling like I’d just been in a great cathedral to learning. Our friends at Executive Millwork in Calgary performed the millwork contract. They did a spectacular job. The tiniest wood details were given careful attention. They truly did our industry proud. I urge all lovers of architecture and millwork and libraries to make Calgary a destination and visit this spectacular building. https://morinwood.ca/wp-content/uploads/2014/02/Calgary-Library.jpeg 900 1200 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2018-11-12 18:49:482020-04-20 13:03:32Amazing Calgary Library Where are all the Women in Construction July 1, 2018 /in News, Uncategorised /by Tom Morin Construction has traditionally been considered a male bastion where only a rare few women could succeed. Despite some big shifts by government and business, women still make up only a pittance of the workforce. Douglas sets out to discover why… Read the article featuring our Morinwood staff here https://morinwood.ca/wp-content/uploads/2019/07/WomenConstruction.jpg 667 1000 Tom Morin http://morinwood.ca/wp-content/uploads/2019/01/Morinwood-Artboard-1@2x.png Tom Morin2018-07-01 18:20:312020-04-27 08:38:57Where are all the Women in Construction IT’S TIME TO BUILDApril 19, 2020 - 9:40 am Leading in Tough Times: Wisdom from CEO’sMarch 22, 2020 - 1:43 am Wisdom’s retirement partyOctober 22, 2019 - 9:37 am Morinwood Mfg Inc 2049 Keating Cross Road Tender invitations Victoria: 250.479.0581 Vancouver: 778.374.3636 We invest in dedicated people to help them realize their potential. We help our staff find their greatest strengths and focus on growing them. See our job openings or contact us for more information. © 2011-19 Morinwood	cc/2021-04/en_middle_0036.json.gz/line960
__label__wiki	0.996711	0.996711	Soul - Funk Brass - Military Stage - Screen Folk - Country usbfoot » Classical » Vaughan Williams, London Philharmonic, Sir Adrian Boult - A London Symphony (Symphony No. 2) Vaughan Williams, London Philharmonic, Sir Adrian Boult - A London Symphony (Symphony No. 2) download flac Performer: Vaughan Williams Title: A London Symphony (Symphony No. 2) Country: UK & US Other formats: FLAC VOX MIDI MOD AAC WAV WMA Download FLAC Vaughan Williams Romantic 1971 UK and US Find a Vaughan Williams, London Philharmonic, Sir Adrian Boult - A London Symphony (Symphony No. 2) first pressing or reissue. Complete your Vaughan Williams, London Philharmonic, Sir Adrian Boult collection. Deutsch English Español Français Italiano 日本語. More Images. Kirsten Flagstad, London Philharmonic Orchestra, Sir Adrian Boult - . Bach: Herz und Mund und Tat und Leben Cantata, BWV 147 - Jesu joy of man's desiring. The 101 Most Essential Classical Music Pieces Ever. London Philharmonic Orchestra, Sir Adrian Boult, E. Power Biggs - Organ Concerto No. 1 In G Minor, Opus 4-I. Adagio. Sir Adrian Boult - The Lark Ascending, for Violin and Orchestra (Excerpt, Opening). London Philharmonic Orchestra, Ральф Воан-Уильямс, Sir Adrian Boult - Partita For Double String Orchestra: I Prelude (Andante Tranquillo) 06:31. London Philharmonic Orchestra, Ральф Воан-Уильямс, Sir Adrian Boult - Partita For Double String Orchestra: III Intermezzo (Homage To Henry Hall) 04:24. London Philharmonic Orchestra, Ральф Воан-Уильямс, Sir Adrian Boult - Partita For Double String Orchestra: IV Fantasia (Allegro) 06:11. London Philharmonic Orchestra, Ральф Воан-Уильямс, Sir Adrian Boult - Partita For Double String Orchestra: II Scherzo Ostinato (Presto) 04:25. Pastoral Symphony (Symphony No. 3): III. Moderato pesante - Presto. London Philharmonic Orchestra & Sir Adrian Boult. 4. Pastoral Symphony (Symphony No. 3): IV. Lento - Moderato maestoso. 5. Symphony No. 5 in D Major: I. Preludio (Moderato - Allegro - Tempo primo). 6. 5 in D Major: II. The Symphony No. 9 in E minor was the last symphony written by the British composer Ralph Vaughan Williams. He composed it from 1956 to 1957 and it was given its premiere performance in London by the Royal Philharmonic Orchestra conducted by Malcolm Sargent on 2 April 1958, in the composer's eighty-sixth year. It was subsequently performed on 5 August 1958 by the BBC Symphony Orchestra under the direction of Malcolm Sargent at a Promenade Concert. Exclusive discount for Prime members. Sample this album Artist - Artist (Sample). 1. 30. A Pastoral Symphony: I. Molto moderato. by London Philharmonic Orchestra/Sir Adrian Boult. Molto moderato by London Philharmonic Orchestra/Sir Adrian Boult. 2. A Pastoral Symphony: II. Lento moderato. A Sea Symphony: II. On the beach at night, alone. Ralph Vaughan Williams. A Sea Symphony: IV. The explorers. 3. A Sea Symphony: I. A song for all seas, all ships. A Sea Symphony: III. (Scherzo) The waves. London Philharmonic OrchestraSir Adrian Boult. A Sea Symphony (Symphony No. 1): I. A Song for All Seas, All Ships (Moderato maestoso), 1. Behold, 03:12. London Philharmonic OrchestraSir Adrian Boult I. Lento—Allegro Risoluto 14:16 II. Lento 9:30 III. Scherzo: (Nocturne) Allegro Vivace 7:02 IV. Andante Con Moto—Maestoso Alla Marcia 11:53 S 36838, S-36838 Vaughan Williams, London Philharmonic, Sir Adrian Boult Vaughan Williams, London Philharmonic, Sir Adrian Boult - A London Symphony (Symphony No. 2) ‎(LP) Angel Records, EMI S 36838, S-36838 UK & US 1971 ASD 2740, ASD. 2740 Vaughan Williams* - London Philharmonic Orchestra* - Sir Adrian Boult Vaughan Williams* - London Philharmonic Orchestra* - Sir Adrian Boult - A London Symphony ‎(LP) His Master's Voice, His Master's Voice ASD 2740, ASD. 2740 UK 1971 ASD 2740 Vaughan Williams* - London Philharmonic Orchestra* - Sir Adrian Boult Vaughan Williams* - London Philharmonic Orchestra* - Sir Adrian Boult - A London Symphony ‎(LP, 1st) His Master's Voice ASD 2740 UK 1971 0626 Vaughan Williams* "London" Symphony ‎(Cass, Album, Club) World Cassette Club 0626 Australia 1974 S/5703 Vaughan Williams* "London" Symphony ‎(LP, Album, Club) World Record Club S/5703 Australia 1974 8979, 8978 8979 Vaughan Williams* "London" Symphony ‎(Reel, 4tr Stereo, 7" Reel, Album, Club) World Tape Club, World Tape Club, World Record Club 8979, 8978 8979 Australia 1974 Related at Vaughan Williams, London Philharmonic, Sir Adrian Boult - A London Symphony (Symphony No. 2) FLAC albums Ralph Vaughan Williams / Sir Adrian Boult, The London Philharmonic Choir And Orchestra - The Pilgrim's Progress [World Premiere Recording] album download... Style: Opera Elgar - Sir Adrian Boult, London Philharmonic Orchestra - Symphony No 1 In A Flat album download... Beethoven, London Philharmonic Promenade Orchestra, Sir Adrian Boult - Symphony No. 3 In E Flat Major "Eroica" album download... Tchaikovsky, Sir Adrian Boult, The London Philharmonic Orchestra - Symphony No. 3 In D Major Opus 29 "Polish" album download... Gustav Holst, BBC Chorus ∙ BBC Symphony Orchestra, London Philharmonic Orchestra, Sir Adrian Boult - The Hymn Of Jesus album download... Vaughan Williams, Sir Adrian Boult, London Philharmonic Orchestra, London Philharmonic Choir, Peter Katin - Symphony No. 9 / Fantasia On The 'Old 104th' album download... Grieg, Schumann, Shura Cherkassky, London Philharmonic Orchestra Conducted By Sir Adrian Boult - Piano Concerto In A Minor Op. 16 / Piano Concerto In A Minor Op.54 album download... Elgar / Vaughan Williams - Sir Adrian Boult, London Symphony Orchestra - Enigma Variations / English Folk Song Suite / Fantasia On 'Greensleeves' album download... Vaughan Williams – London Philharmonic Orchestra, Vernon Handley - A London Symphony album download... usbfoot.fr © 2017-2019 All right reserved	cc/2021-04/en_middle_0036.json.gz/line964
__label__cc	0.700997	0.299003	Home Working & Performing Coronavirus Guidance Workplace Advice Live Performances during Covid-19 Guidance on returning to working during the Covid-19 outbreak, for freelance musicians working in the live sector. Please note that lockdowns across the UK mean that in many places, performances in front of a live audience are not able to take place. See our latest guidance on the Government’s Covid-19 restrictions. Please note that this guidance only covers the health & safety aspects of a return to work. For concerns on contractual relationships please talk to your regional office. The guidance that we’ve provided is in relation to the Government’s advice on social distancing, and you can read more from the NHS and on the Government’s website. See our basic guidance for what you should look out for when returning to work. The guidance below covers this in more detail, but again this is for general guidance only and does not represent any instruction, encouragement or advice to return to or begin work. A Risk Assessment must be carried out The main thing that must be done in all work situations is a Risk Assessment (RA). For any workspace you are entering, the organisation you are working for should have carried out a RA. Every existing Risk Assessment has to be re-done taking into account the effect of Coronavirus (Covid 19). As well as the RA covering Covid-19, all aspects of your work should be covered also, e.g, fire, evacuation, trip hazards, noise etc. If not, a separate RA should be in place. If you are working in a venue owned by another organisation, the owner of those premises, should have carried out a Risk Assessment (RA). Both the venue and the owner of the premises need to have integrated their findings. Accessing the Risk Assessment If you are a self-employed worker, you are in essence a sub-contractor and the engager or venue owner has to share their RA with you. The situation for those working in London’s West End and around the UK on touring or static theatre touring shows is different. Advice has been provided to our MU safety reps, so contact them. If you are engaged on a show that does not have a safety rep in place please contact your MU Regional Office. A Risk Assessment may conclude the work can not be done A RA will reference the medical and governmental advice and legislation. However, a RA needs to look at all the aspects being presented. This may result in conclusions going beyond the official advice (which is geared to the general situation). Some RAs have concluded that the balance of risk against the need for the work to be done tips the balance over to not carrying out the work. The RA must calculate whether the risk is acceptable. If the conclusion is to do the work/tasks, there must then be a plan developed to minimise risks. We accept this is all a difficult area and recognise that many of the problems identified are complex. This means there must be full and open discussion involving you and other workers/sub-contractors. It must also be recognised that this situation affects all those working whether musicians, support staff, admin or management. Some issues must be resolved before returning to work Some areas the RA must consider are: Going out to work in premises or areas not directly controlled by the organisation/body that contracts you e.g. theatres, concert halls, pubs & clubs, schools, open air events, studios Other artists and support staff Deps and extras Many of the suggested measures in official advice raise practical problems for most musicians, e.g. wearing face masks, use of screens, keeping distance from work colleagues, travelling to work, working from home. All suggested new measures must look at how they interact with existing hazards. Spacing raises difficult problems which must be looked at in detail. These issues must be resolved before starting work. If you need advice in any situation contact your MU Regional Office. Hazards specifically affecting musicians There are some specific potential hazards for musicians (to be assessed by a competent person) such as: Airborne transmissions – the aerosol effect Orchestra and band layouts. Provision of adequate backstage facilities (e.g. toilets, washing areas, changing areas, resting areas) to ensure best safeguarding standards. Air quality considerations – including extraction and air conditioning systems. Any audience. Problems for those involved in teaching, particularly of children, whether in groups or individually e.g. preparation/cleaning of instruments to be used raises special considerations. in studios balancing the technical requirements for recording whilst applying the safety measures to minimise exposure. Some additional factors must be part of a RA such as – those most at risk e.g. age, ethnicity, existing medical conditions, pregnancy, the effect on stress. Dealing with reasonable concerns for your safety We can assist freelance workers in dealing with the specific circumstances they face. If you are not happy with the situation you are asked to work in, you can always say you do not wish to start work until your reasonable concerns have been rectified. We advise you take advice from your MU officials about the implications this may have around your contract and being paid. Any return to work process takes place in the context of any legislation passed by Government, both across Britain and by the devolved Governments. As, at present, the exact nature of the virus is not totally understood, then big questions arise about whether further waves of infection will be seen, whether having had infection you are immune, about how, in the longer term, to contain infection and how it may be transmitted etc.	cc/2021-04/en_middle_0036.json.gz/line965
__label__cc	0.508478	0.491522	Chinese Economy Rebounds from Early Coronavirus Pandemic Pall Supporting families uprooted amid violence in Myanmar Jordan Among First to Vaccinate UN-Registered Refugees It Hosts COVID Vaccines Open Door for Cancer Treatments, Others Myanmar News Gazette Latest News From Myanmar Wives of Convicted Myanmar Reporters Shocked by Sentences September 4, 2018 myanmarnewsgazette.com YANGON, MYANMAR The wives of two Myanmar reporters for the Reuters news agency sentenced to seven years’ imprisonment for possessing state secrets said Tuesday they were shocked by the court’s decision. Wa Lone and Kyaw Soe Oo were sentenced Monday in proceedings that were widely decried as unfair. They had reported about the army’s brutal counterinsurgency campaign that drove 700,000 members of the Muslim Rohingya minority to flee to Bangladesh. The subject is sensitive in Myanmar because of worldwide condemnation of the military’s human rights abuses, which it denies. Wa Lone’s wife, Pan Ei Mon, said at a news conference that she never expected such a harsh punishment “because everyone knows that they didn’t do anything wrong.” The two men testified that they had been framed by the police. Pan Ei Mon gave birth to the couple’s first child in Yangon on Aug. 10, but her husband has not seen their daughter. “After I gave birth, I continued to keep strong with the hope that my daughter and her father will meet soon. But I felt like my hope was broken after the verdict yesterday. I am hopeless now,” she said. Kyaw Soe Oo’s wife, Chit Su, also said she had expected her husband would be coming home. They have a 3-year-old daughter. “I believed he would be free, he felt the same,” she said. “But it didn’t happen, I felt like I am a crazy person.” She said she still hopes for mercy from the state. At the same time, she remains proud that her husband did his duty as a journalist. The lawyers for the journalists said at the news conference they would do whatever they could to get their clients freed. They can file an appeal or ask for a pardon, or hope the reporters could be freed under a general amnesty for prisoners. Pan Ei Mon said she was saddened and hurt that the country’s leader, Nobel Peace Prize laureate Aung San Suu Kyi, had taken a legalistic position in a June interview with Japanese broadcaster NHK by saying the two reporters were arrested for breaking the Official Secret Act, not because they exposed the army’s abuses. “I am very sad about what she answered because she was the one whom we always admired and respected,” she said. “We loved and respected her so much,” she said. “We feel very sad as our respected person has the wrong opinion about us.” The case drew worldwide attention as an example of how democratic reforms in long-isolated Myanmar have stalled under Suu Kyi’s civilian government, which took power in 2016. Although the military, which ruled the country for a half-century, maintains control of several key ministries, Suu Kyi’s rise to government leader had raised hopes for an accelerated transition to full democracy, and her stance on the Rohingya crisis has disappointed many former admirers. ← New R&D campus at Technology Base in Twente Lithium Werks และ Super B เห็นพ้องในการผสานการใช้พลังงานการส่งผ่านพลังงานทั่วโลก → MYANMAR-THAILAND BORDER TRADE EXCEEDS 1.3 BLN USD IN FY 2017-18 March 15, 2018 myanmarnewsgazette.com Intimate Portraits Capture Loss, Hopes of 2020’s Senior Class May 19, 2020 May 20, 2020 web Desk 0 MALAYSIA SAYS INDONESIA HAS APOLOGISED FOR ALLEGED KIDNAPPING OF FIVE LOGGERS AT BORDER AREA December 24, 2018 myanmarnewsgazette.com Archives Select Month January 2021 (98) December 2020 (171) November 2020 (177) October 2020 (235) September 2020 (225) August 2020 (194) July 2020 (222) June 2020 (210) May 2020 (161) April 2020 (122) March 2020 (216) February 2020 (157) January 2020 (162) December 2019 (166) November 2019 (151) October 2019 (164) September 2019 (187) August 2019 (119) July 2019 (158) June 2019 (142) May 2019 (190) April 2019 (185) March 2019 (182) February 2019 (139) January 2019 (180) December 2018 (158) November 2018 (171) October 2018 (173) September 2018 (191) August 2018 (221) July 2018 (175) June 2018 (176) May 2018 (189) April 2018 (229) March 2018 (269) February 2018 (185) January 2018 (124) December 2017 (88) November 2017 (116) October 2017 (209) September 2017 (118) January 18, 2021 myanmarnewsgazette.com China says it’s economy grew 2.3% in 2020, recovering from the novel coronavirus pandemic that brought the global economy to a screeching halt. The world’s second-largest economy was boosted by a 6.5% increase in the fourth and final quarter of the y… General Press Releases Toga Limited Unveils Yippi X, New Mobile Apps and Partnerships at the Inaugural ASEAN New Tech Conference January 16, 2021 Asianet Pakistan Supporting families uprooted amid violence in Myanmar January 17, 2021 Jordan Among First to Vaccinate UN-Registered Refugees It Hosts January 17, 2021 COVID Vaccines Open Door for Cancer Treatments, Others January 17, 2021 Nepali Climbers Make Historic Winter Ascent of Pakistan’s K2 January 16, 2021 India Begins COVID-19 Inoculation Campaign January 16, 2021 US COVID Death Toll Rapidly Approaching 400k, Says Johns Hopkins January 15, 2021 Worldwide COVID-19 Deaths Top 2 Million January 15, 2021 As WHO Begins COVID-19 Probe, Speculation, Tensions Abound January 14, 2021 Biden Announces $1.9 Trillion Coronavirus Relief Package January 14, 2021 The Myanmar News Gazette has completed it’s yet another successful year and now headings towards the goals which it has set to achieve throughout the year of 2016. This online news ... [Read More] Copyright © 2021 - Myanmar News Gazette. All Rights Reserved.	cc/2021-04/en_middle_0036.json.gz/line967
__label__wiki	0.516879	0.516879	Navigating the Post #MeToo World: What This Means for Our Workplace (MELBOURNE) By \| Events \| No Comments Women are no longer tolerating micro-inequities and micro-aggressions in the workplace, men feel like they are walking on broken glass and countless people complain that they are going home each day thinking “I should have said something”. Come and explore how the surge in demand to deal with the full spectrum of inappropriate behaviour in the workplace is impacting on organisations and what they are doing about it. Making Inclusion Stick: Solutions that are Brilliant in Their Simplicity (BRISBANE) Why is inclusive leadership so rare and inclusion so hard to sustain? Symmetra will share its global findings on where the inclusion capability gaps are showing up in leadership and how leading organisations are closing this gap, driving inclusion across multiple markets, divisions and teams without breaking the bank and having huge sustainable impact. Build an Inclusive Culture to Be More Ethical? Implications of the Findings of the Hayne Commission (BRISBANE) There is no question that many of the findings of the Hayne Commission and recommendations made by APRA to address ethical breaches in organisations, point to building a more inclusive culture- such as creating the psychological safety for people to demonstrate curiosity, to express diverse perspectives, to counteract group think, and to leverage diversity of thought- all in the interest of adopting a more conscious approach to making more ethical decisions. Whilst no direct reference has been made to building a more inclusive culture to achieve these objectives by the Commission or APRA- it is clear to those who understand what constitutes inclusion in the 21st century, that building an inclusive culture is precisely what needs to be done. Navigating the Post #MeToo World: What This Means for Our Workplace (SYDNEY) Making Inclusion Stick: Solutions that are Brilliant in Their Simplicity (SYDNEY) E-Challenge Symmetra Blog © 2021 E-Challenge. All Rights Reserved.	cc/2021-04/en_middle_0036.json.gz/line971
__label__cc	0.54005	0.45995	Tag: Elvis Presley The Identical: The Next Religious Feel Good Film of 2014 2014 is obviously the year of the religious feel good film and the next one in line is The Identical. Made by City of Peace Films, which is so new there is no existing information about the production company on IMDbPro, this rated PG film – for “smoking and thematic material” – has the feel of an “After School Special” for bigger kids. Author Mike's Film TalkPosted on September 4, 2014 September 4, 2014 Categories EntertainmentTags Elvis Presley, entertainment, Erin Cottrell, film, Ray Liotta, Rock and Roll, Seth Green, The IdenticalLeave a comment on The Identical: The Next Religious Feel Good Film of 2014 Michael Ansara Actor Who Played Cochise and Klingon Kang Dies Aged 91 Author Mike's Film TalkPosted on August 3, 2013 Format LinkCategories EntertainmentTags Barbara Eden, Broken Arrow, Calabasas California, Elvis Presley, entertainment, Harum Scarum, I Dream of Jeannie, John Wayne, Michael Ansara, Star Trek, Stuart Whitman, Syria, The Comancheros2 Comments on Michael Ansara Actor Who Played Cochise and Klingon Kang Dies Aged 91 Robert Pattinson to Kristen Stewart, “B**, Clean your car!” Author Mike's Film TalkPosted on July 9, 2013 Format LinkCategories EntertainmentTags Beyonce Knowles, Elvis Presley, entertainment, Kristen Stewart, Los Angeles, paparazzi, Riley Keough, Robert Pattinson, Staples Center2 Comments on Robert Pattinson to Kristen Stewart, “B*, Clean your car!” Robert Pattinson and The King’s Granddaughter Author Mike's Film TalkPosted on July 3, 2013 Format LinkCategories EntertainmentTags Chanel, Dior, Elvis Presley, entertainment, Katy Perry, Kristen Stewart, Riley Keough, Robert Pattinson, The Runaways, Twilight2 Comments on Robert Pattinson and The King’s Granddaughter Blaming Violence on Video Games and Guns Well it did not take long for someone to make a tenuous connection between the Sandy Hook Shootings and video game violence. The Independent (one of the less tabloid-like newspapers in the UK) featured the following headlines on their website: Adam Lanza: A head full of video games and a house full of guns Journalist David Usborne writes that, “ He [Lanza] is said to have been a fan of computer games featuring warfare and killing. Did he cross some line from the fiction of these games into some twisted, self-realised reality last Friday?” and that ” Ms Lanza [the first victim of son Adam’s killing spree] also had a significant gun collection. Why? Tragically, it was from there that her son took his weapons.” It didn’t take very long for the “nay-sayers” to drag out the modern all-purpose scapegoat of video games. No doubt this will garner a lot of attention from the same folks who scream that films and television are too violent. According to these ninnies, our youth are being traumatized by all this violence and are having a hard time distinguishing from the fiction of the game world and reality. I am sure that there are some “twisted” young (and not so young) individuals who do have a blurred line between fiction and non-fiction. But video games did not cause it. I remember when I was a teenager in high school in the seventies church groups were handing out pamphlets and getting on television and the radio and screaming to high heaven (pun intended) about horror movies and how they were damaging our youth. The same groups completely ignored the fact that most of the films that they were complaining about (slasher films) were actually modern morality plays. In a “slasher” film, if you did things you weren’t supposed to you died. Underage drinking – death; promiscuity – death; smoking – death; basically if you weren’t a sober, virginal non-smoker your clock was cleaned in a pretty gruesome fashion. Sure people are influenced by the media. Television went through a Salem witch trial in the 1970’s as well. There was a glut of cop shows and detective shows. You had Colombo and MacMillan & Wife to name just two. Because of the outcry against violence being shown on the telly, shows were not allowed to show acts of violence. In one episode of McCloud you had a scene where a bad guy walked up behind his victim with a monkey wrench in his hand. You saw him raise the wrench over his head and…Commercial break. When the commercial break finished you came back to the body of the victim lying on the floor (if you were lucky) or you never saw the victim again. This had the effect of leaving you wondering just what the hell had happened. The thing that started the whole “violence on TV is ruining our kids” was two events. One was a made for TV movie called Born Innocent where a young Linda Blair is sent to Juvenile Prison and is raped with a mop (or broom) handle by a gang of prison girls. Right after the movie aired the crime was repeated for real by a group of kids who cited the movie as giving them the idea. The second event was the television airing of the movie Fuzz. Based on Ed McBain‘s 82nd Precinct series it was adapted for a “comic” cop movie starring Burt Reynolds, Raquel Welsh and Harvey Keitel. The basic plot of the film (as in the book) was that someone was going around pouring gasoline on homeless people and burning them alive. Just like Born Innocent, right after Fuzz aired on the “Movie of the Week” on TV somebody got the bright idea to copy the film’s plot. Also again, when they were caught, the perpetrator’s cited the movie as the source of their action. So the American television networks had to “censor” their channels and their output. Did this action stop the crazies from performing heinous acts of murder, mutilation and rape of their fellow-man? I think we all know the answer to that one. There was a similar movement brought against comic books in the 1940’s and 50’s where the industry had to tone down some of their more gruesome comics. Tales of the Crypt was just one comic that got “white washed” in an effort to protect America’s youth from corruption. Rock and roll had a similar problem, on television Elvis Presley could only be shown from the waist up because of his “promiscuous” gyrating hip action while he sang. Heavy Metal bands were accused of putting Satanic verses on their LP’s that could only be heard when the record was played backward. The list goes on and on. Books dealing with violent themes and horror fiction in particular have been given short shrift by a public who were desperate to pin the blame on anyone but the criminal who actually committed the violent crime. But now we have the video game to blame for all the violent crime that today’s youth are committing. Too many hours spent playing Grand Theft Auto or Hitman or insert game name here* and your child will turn into a homicidal maniac. Of course Usborne doesn’t just infer that video (he actually uses the term “computer” games) games are to blame, but the fact that Momma Lanza had a gun collection is thrown into the mix as well. Of course that was the lethal combination. Never mind that Lanza’s own brother stated for the record that Adam had mental problems. But rather than accept that something in the kid snapped that had nothing to do with violent video games and that this something had obviously been building up for some time. The sad thing is, that while people are playing the “blame game” and trying to come up with a palatable reason for Lanza to have gone out and murdered an enormous amount of adults and children, they are ignoring the plain and frustrating truth. We will never know why he did it because he’s dead. The Independent trying to make a link between “computer” games and the guns that Lanza took from his mother is just despicable. It is attempting to milk a bit more out of a horrible situation without waiting for all the facts to be gathered. By printing the article by Usborne, who is after all only doing his job as a journalist, the paper is adding more fuel to an already touchy subject. The fact that the games industry has been self policing their games for some time now; putting recommended age restrictions on the games that they release has not impressed anyone. It is a lot easier to point the finger at the games the companies produce than to point the finger at the parents who do not monitor what their underage children are playing. If anyone has played any of the Call of Duty (COD) on-line multiplayer games they will notice that some of the other players are so young that their balls have not dropped yet squeakily cursing you for killing them. So the first question that comes up, after I’ve told the kid that his “momma is calling for him” is to wonder where the hell his parents are and why they let him buy, let alone play, a game that is not intended for little kids. I think that if the media is going to try to make this story run a bit longer, they need to look at the whole situation as the facts become available and not add to an already eager public’s desire to find a scapegoat. Don’t hate the games, heal the players (thefutureamerican.wordpress.com) Writing with a heavy heart (mommybrainblog.wordpress.com) Initial Thoughts on the Newtown Shooting (thelivingnotebook.com) y (margosblog.com) Gun Laws in the wake of the Connecticut Mass Shooting (blogtruth.wordpress.com) Mob Blames Mass Effect For School Shooting, Is Embarrassingly Wrong (kotaku.com) America Has A Morality Problem, Not A Gun Problem (dailypaul.com) Viewers question violent ‘Gangster Squad’ ad aired during NFL game (twitchy.com) Weeping for Sandy Hook Elementary (masculinityu.wordpress.com) CT Sen. Lieberman: Video Games, Movies ‘Cause Vulnerable Young Men To Be More Violent’ (mediaite.com) Author Mike's Film TalkPosted on December 17, 2012 December 18, 2012 Categories BlogTags Adam, Born Innocent, Elvis Presley, guns, Lanza, Linda Blair, McCloud, Multiplayer game, murder spree. on-line gaming, Television, Video game controversy16 Comments on Blaming Violence on Video Games and Guns	cc/2021-04/en_middle_0036.json.gz/line975
__label__cc	0.598361	0.401639	The Mind Cult Discussions on developmental psychology, peer interaction and culture. And other stuff. Tag Archives: searle Property transfers and property rights. Kim & Kalish. Kim, S., & Kalish, C. W. (2009). Children’s ascriptions of property rights with changes of ownership. Cognitive Development, 24(3), 322–336. https://doi.org/10.1016/J.COGDEV.2009.03.004 The article starts with a claim that I fully endorse: that ownership is an institutional (as opposed to a “brute”) fact. The term “institutional” is here obviously used in the sense it has in John Searle’s philosophy of social reality. However, the authors distort this concept of ownership as an institution in that they make ownership depend almost exclusively on people’s intentions. As they put it: “Giving someone an object to hold, to borrow, or “for keeps” may all involve the same physical motions. It is the intentions of the parties involved that determine whether ownership has been transferred.” Searle’s is not a subjectivist approach. Intentionality is an important aspect of institutions, yes, but intentions are not free-floating entities. Thus, for a sale to take place, it’s not enough to have the intention to sell, one also needs to meet a number of objective conditions (such as being the previous owner of the object one is selling) as well as performing certain acts in a proper manner (stating that one wants to sell an item; receiving the money and handing out the item; performing certain speech acts, etc.) Intentions are an aspect of a broader, social reality, and they are interpreted according to social practices. Social institutions are not made of human intentions only; they are the product of constitutive rules (Searle’s term), which determine the meaning of certain actions. The paper’s reduction of institutions to intentions is an error frequently observed in psychologists. Another problem with this paper is the hazy discussion of previous research in the introduction. The authors quote several sources that connect the concepts of current possession, first possession and ownership, but the precise meaning of such connections is not clear. Thus, they quote Shantz (1981), who claims that possession is “nine-tenths of a law,” a saying that suggests that a possessor has an advantageous legal position when claiming property, without explaining how this phrase applies to children and the development of ownership. They also quote Furby (1978), who found that “owners having or keeping the object” was “central to definitions of ownership throughout elementary school years,” establishing again a vague relationship between possession and ownership. What does “central to” mean? Are they implying that children confuse or mix up possession and ownership? Or, alternatively, that children distinguish one from the other, while justifying ownership claims by referring to current physical control of the object? Further, the authors quote Cram and Ng (1989), who found that 4–5-year-old children’s conception of ownership was related to physical contact. What does “related to” mean here? Over and over again, they suggest a close relationship between possession and ownership but do not clarify how this relationship operates in children. To make things more confusing, they then proceed to quote research demonstrating that children use previous possession to justify current ownership. “Preschool children recognize that ownership is more than immediate physical contact. (…) Toddlers and preschoolers accept, “I had it first” as a basis for settling property disputes, and initial possessors typically prevail”. But then, which one is more important to justify ownership: current possession or previous possession? How do previous and current possession relate to each other, according to extant research? To sum up, the introduction provides a very confusing developmental account of the relationships between previous possession, current possession and ownership. They then tackle their specific topic: property transfers. “Recent evidence suggests that 4-year-olds are beginning to accept transfer of rights at least in one highly ritualized context: receiving a birthday present.” However, “studies have not carefully articulated the criteria for establishing that ownership was actually transferred. In particular, conclusions that children do understand transfer are based on their assigning some rights to receivers” but without the givers losing those rights. “Both buyers and gift recipients can take the goods home.” Apparently, then, young children accept that recipients gain property rights but deny that givers relinquish rights. If so, then young children understand ownership transfers as a kind of lending. The recipient is allowed to use the property, but the original owner retains ultimate control. A true understanding of ownership transfer, however, requires that original owners be seen as losing their original property rights. The authors propose to use the judgment that the recipient has a stronger claim on the property than the original owner as the key indicator of a true transfer of ownership. Each participant heard three stories about conflict between an owner and a non-owner over doing something with an object. The conflicts varied according to the types of transfer at stake: finding, borrowing, selling. Participants were asked about the characters’ right to novel use, re-categorization, alteration, lending (to a third person), and discarding the object. For example, in the discard condition they were asked: “Who should get to decide whether throw away the hat or not?” The researchers found that adults and older children judged that original owners had control in the finding and borrowing stories, and that new owners (buyers) had control in the selling story. Younger children showed a similar pattern but were less consistent in privileging new owners in the selling story. In owner–finder and owner–borrower stories, participants of all ages reliably assigned control to the owner. Transfers of physical possession do not constitute changes in ownership/property rights. Agents who found or borrowed property did not acquire the rights to use it against the wishes of the original owners. This is the case for practically all participants. Now, older children and adults reliably indicated that new owners (buyers) could control property against the wishes of original owners (sellers). Young children, however, selected owners significantly less often in conflicts with sellers than in conflicts with borrowers or finders. That is, a person receiving ownership via transfer does not have the same rights to control property as someone retaining original ownership. Even younger children, however, treated buyers as having more control than finders or borrowers. They saw buyers as owners that are not granted unlimited control of their property. Experiment 2 is similar to experiment 1, but now participants evaluated two instances of the same dispute, involving the same people, actions, and objects: once before and once after a transfer of ownership occurred. Instead of different types of actions (lending, discarding, etc.) here researchers used just one alteration of the object (cutting out a magazine, coloring a picture) and varied the agents’ ability (good at coloring vs. bad at coloring). Experiment 2 directly examined ownership transfer—losing and gaining ownership rights. It was found that, with increasing age, participants more reliably judged that owners could assert control of their property against the wishes of non-owners. Preschool-aged children showed one of two patterns. 1) They either appreciated owners’ rights or 2) they rejected any attempt to alter the objects. 1) When young children endorsed property rights, they did so by using the same criteria as adults and older children. Young children were not likely to assign control to original owners. Current ownership, whether initial or transferred, was the only thing that enabled control of property. Children do not indiscriminately adopt a “first-owner” principle, nor do they respond according to the intrinsic value of proposed actions. Rather, young children keep track of the ownership across transfers and assign rights accordingly, at least in the context of gift-giving. 2) The other response pattern was a denial that any character could exert control of an object over the objections of another. Thus, some younger children rejected all proposals. They denied control to original owners as well as recipient owners. Whenever young children assigned control to one actor rather than another they did so in the same way as did adults (pattern 1); that is, only ownership status was ever used as the basis for assigning property rights. A majority of participants (including all adults) reliably indicated that an owner could control their property against the wishes of a non-owner. Participants responded that non-owners ought to defer to the wishes of owners regarding the use, alteration, lending, and disposal of those objects. The researchers found that young children’s judgments are consistent with a “first-owner” model to a limited extent. Preschoolers often judged that initial owners retained some rights to their property; the rights of buyers or recipients of gifts were limited. For this reason, young children were less consistent in assigning owners control of property than were adults. However, the results also indicate that young children agreed with older children and adults in their identifications of ownership. They designated recipients as the owners in cases of gift-giving and buying, but not in cases of borrowing or finding. The present study suggests developmental continuity in identification of ownership, although young children may have different ideas about what owners can do with their property, that is, they apply the concept of property and coordinate property rights together with other considerations such as outcomes, fairness, object attachment and interpersonal relationships differently from adults. The major difference between children and adults seems to be that adults have most clearly distinguished ownership rights from other considerations that affect decisions about property. There is also the problem of narrative context. The stories may have involved more than ownership rights. Many young children may not distinguish what owners may and may not do from other considerations, such as what friends may and may not do. Structuring the narratives in a different way may yield quite different results. One problem: other studies have found a strong first possessor bias in children, and claim that children do not fully understand ownership transfers until they are 10 years-old. Who is right then? Check: https://mind-cult.com/2019/02/16/exploring-the-first-possessor-bias-in-children-nole-keil/ This entry was posted in ownership, ownership transfer, prior possession and tagged first possession, first possession bias, gift giving, institutional facts, intentions, kalish, kim, prior possession, property rights, property transfer, searle on February 24, 2019 by gusfai. My son is an adorable and smart kid. I have talked about him in this blog, especially to provide illustrations of developmental milestones. But, in order to put his achievements in context, it’s necessary to mention that he’s developmentally delayed. That is, he’s 4 years 1 month old now, and he’s mastering certain behaviors that are typical of 2- and 3-year-olds. For example, he has recently learned how to say “I’m sorry.” There are several ways to perform this speech act (Austin, 1962; Searle, 1969) in Spanish; he uses “lo siento” instead of “perdón”, the latter being more common here in Argentina. I guess he picked up “lo siento” from TV shows such as Caillou or Go Diego Go, that are dubbed in Mexico or Spain. The speech act of apologizing is a very peculiar and interesting one. It involves a) the recognition that one has done something wrong (something morally bad, or perhaps neglectful or careless), as well as b) the request that the person one is interacting with forgives (gives up feelings of anger and decides not to punish) this behavior. It also implies that the person apologizing is committed to avoid such wrongdoing in the future. There’s a whole conception of responsibility implicit in this apparently simple speech act. As I have argued elsewhere, I support the Piagetian idea that action precedes thought (Piaget, 1976), which on the level of speech acts translates as: rhetorical moves precede explicit concepts. In other words, my son apologizes because he senses he can get certain pragmatic results by using this speech act. He performs the speech act pretty well, with the right tone in his voice and a cute expression on his face. So he convinces me and I capitulate: “ok, ok, but don’t do that again”. Yet it’s easy to see he’s not mastered the rules of apology. For example, he tells me “I’m going to wash my hands”, and so I reply, “ok, but please be careful not to make a mess with the water,” and then he says “I am sorry”. Or, when he’s intentionally kicking a chair, I tell him “don’t do that again” and he says “I’m sorry” but continues kicking the chair just as before. So he’s contradicting two felicity conditions of the speech act of apologizing: in the former example he’s not committed the wrongdoing yet; in the latter, he’s not committed to avoid doing it again in the future. To sum up: my son is pragmatically effective but he’s still not conceptually clear about what “I’m sorry” means. He doesn’t get responsibility, pardon, commitment, etc. Conceptual clarity about the meaning of apologies will arrive later, as a result of reflection on this interaction with the world, favored by social instruction, social representations and symbolic interaction in general. Austin, J. L. (1962). How to do things with words. Oxford: Oxford University Press. doi:10.2307/3326622 Piaget, J. (1976). The grasp of consciousness (S. Wedgwood, Trans.). Cambridge Massachusettes Harvard University PressOriginal Work Published 1974. Searle, J. R. (1969). Speech Acts: An Essay in the Philosophy of Language (p. 203). Cambridge University Press. Retrieved from http://www.amazon.com/Speech-Acts-Essay-Philosophy-Language/dp/052109626X This entry was posted in developmental psychology, embodied self, institutional experience, normativity, rhetoric and argumentation, self and tagged apologies, austin, grasp of consciousness, human action, piaget, rhetoric and argumentation, searle, sorry on August 1, 2014 by gusfai. Ownership in children’s justifications. Friedman and Nancekivell Ultimatum and dictator in four-year-olds Exploring the first possessor bias in children. Nole & Keil. Klass & Zeiler: Endowment theory is wrong. Property transfers a… on Exploring the first possessor… gusfai on Change is death tabularin0a on Change is death Kitchener on Piaget… on Piaget and the logic of a… Kitchener on Piaget… on Misunderstanding Piaget a sense of justice economic psychology embodied self endowment effect ideas for experiments inclusion-exclusion institutional experience ownership transfer prior possession rhetoric and argumentation social intuitionism territoriality associative reciprocity castorina creation principle first possession first possession bias haidt human action kanngiesser moral emotions noles ori friedman ownership claims ownership heuristics parochialism perret-clermont possessive prosocial behavior psychological ownership rochat sense of justice tomasello turiel warneken	cc/2021-04/en_middle_0036.json.gz/line978
__label__cc	0.692457	0.307543	The development of the square, Giżycko The main guidelines for creating the project were the existing terrain and the improvement of communication on the square in the city center. The new square introduces fluidity to this place, increases freedom of movement. With the help of delicate steps that flow through the entire square and connect the raised part with the others, set below, a natural line of this place was created based on the orthogonal grid of concrete slabs that existed Place: Poland, Giżycko Investor: City of Giżycko Status: competition project Authors: Marcin Kitala The square line was created as a result of pedestrian traffic analysis that runs diagonally across the square. At the intersection of these paths, a place where the square’s users can meet naturally arose. The goal was not to let people through the square who shorten their path going to school or work, but to invite them inside and spend time here. At the junction of the paths, a cubature was designed. It is recessed into the ground so that pedestrian traffic can still take place over the slightly raised square panels on the roof of the pavilion. The essence of the project was to separate individual zones that interact with each other. A recreation area for children was created, a small hill intended for resting and observing the inhabitants, an amphitheater auditorium, an information pavilion or water elements inscribed in square plates. 2021 © Natura i architektura. Privacy policy Realization: SelfMade	cc/2021-04/en_middle_0036.json.gz/line980
__label__wiki	0.95046	0.95046	NFL Rumors: Patriots Host Demaryius Thomas, T.J. Yeldon On Free Agent Visits by Zack Cox Two notable veterans made appearances at Gillette Stadium on Wednesday. Wide receiver Demaryius Thomas and running back T.J. Yeldon both traveled to the New England Patriots’ facility for free agent visits, according to a report from ESPN’s Field Yates. The Patriots know Thomas well from his eight-plus-season run with the Denver Broncos, which ended when Denver dealt him to the Houston Texans ahead of last year’s trade deadline. The 31-year-old tore his Achilles in his third game with Houston, was released in February and has yet to latch on with a new team. Thomas was one of the NFL’s premier receivers from 2012 to 2017, averaging 95.8 catches, 1,303.2 yards and 8.5 touchdowns per season and earning four Pro Bowl selections. His best days are behind him at this point, but if he can return to full health, he could provide a real boost to a Patriots receiving corps that currently lacks a proven No. 2 behind Julian Edelman. Patriots offensive coordinator Josh McDaniels coached Thomas early in his career in Denver, and New England reportedly attempted to trade for him last season. NFL Media’s James Palmer reported Thomas’ visit “went well.” Demaryius Thomas finished his visit with the Patriots a little while ago, per source. It went well from what I’m told. The Patriots are smart to bring in a talented player while he is still recovering to take a look. Thomas is on schedule to be back sooner than expected. — James Palmer (@JamesPalmerTV) April 10, 2019 Yeldon, meanwhile, is seeking a new home after his rookie contract with the Jacksonville Jaguars expired last month. The 2015 second-round pick never has put up stellar rushing numbers — his 740-yard, two-touchdown rookie campaign remains his most productive at the NFL level — but has been a solid contributor in the passing game. He’s caught 158 balls for 1,212 yards and six scores over his four-year career, including a 53-472-4 line in 12 games last season. The Patriots are much deeper at running back than receiver. The backfield trifecta of Sony Michel, James White and Rex Burkhead is set to return this season, as is special teamer Brandon Bolden, who’s back with the Patriots after a one-year stint with the Miami Dolphins. New England also hosted quarterback prospects Daniel Jones and Will Grier for pre-draft visits Wednesday, according to a report from NFL Media’s Ian Rapoport. Thumbnail photo via Mark J. Rebilas/USA TODAY Sports Images MSN Distribution New England Patriots Top Stories Yahoo Distribution Zack Cox Updated Look At Patriots’ Pass-Catching Options After Tight End Addition Charlie McAvoy Fine After Twisting Knee At Practice, But Video Looks Ugly Could Robert Saleh Hire Cement AFC East As NFL’s Best-Coached Division? Remember When Packers’ Mike Pettine Spoke About Tom Brady During Deflategate? What If Bill Belichick Retired From Patriots? Colin Cowherd Raises Question Patriots Draft Steal Mike Onwenu Earns Spot On PFWA All-Rookie Team	cc/2021-04/en_middle_0036.json.gz/line984
__label__wiki	0.516873	0.516873	The New Americana Music Handbook Trilogy and Jason Isbell & The 400 Unit at The Ohio Theatre Posted on September 24, 2017 September 24, 2017 by Aaron Wetli Jason Isbell is the most important person in contemporary popular American music. This is not an opinion, that is a fact – at least on my blog. For this entry we will be discussing his recent Columbus, Ohio, live performance (with his backing band The 400 Unit) at The Ohio Theatre and his trio of albums. Also, his wife Amanda Shires is my celebrity crush (check out her NPR Music page and you will understand why) and a great musician, so he has that going for him, which is nice. For those who are not familiar, Isbell was a member of Country Rock/Americana Music stalwarts Drive-By-Truckers from 2001-2007. In 2007 he struck out on his own and has released six solo albums since. In 2012, Isbell became sober and his work since has reflected his past struggles and future optimism. His lyrics have also garnered support from his peers to crown him as the greatest lyricist of his generation. If you don’t believe me, just look at what this Muppet had to say. The three albums Isbell has released since becoming sober are, in order: Southeastern, Something More Than Free and The Nashville Sound. These albums have taken Isbell to new levels of achievement, both critically and commercially, and led to two Grammys and four American Music Honors & Awards. These albums also compromise what I like to call the New Americana Handbook Trilogy. Lets review each. SOUTHEASTERN (2013) I first became familiar with Isbell while listening to Fresh Air on a road trip to Philadelphia. In mid interview, host Terry Gross asked Isbell to perform his popular song Elephant, which tells the story of two barfly friends, one of which is dying of cancer. I was blown away by the story he told and the lyrics he emoted. I was instantly hooked and have been a fan ever since. Other top picks include: Cover Me Up – an acoustic love song about the need to be redeemed and falling for your redeemer. Stockholm – a tune about leaving your old habits for a new life and embracing your ‘Stockholm Syndrome’. This is also the first song, at least that I was familiar with, in which Isbell’s spirituality plays a role: ‘Read the good book and studied it too But nothin’ prepared me for livin’ with you’ Different Days – another diddy about getting sober with bonus points for finding a rhyme scheme for benzodiazepine. Isbell should have won the Grammy for this feat alone. Live Oak – my favorite song on the album is an acoustic murder ballad the would have felt at home on Bruce Springsteen’s Nebraska. The lyrics are intense, and Isbell finds a macabre use for the term ‘water table line’. Something More Than Free (2015) Of the three albums being reviewed today, Something More Than Free took the longest for me to appreciate but has grown on me the most. It is an album that accumulates interest on each listen and is perfect for a road trip. Isbell doesn’t stray far from the blueprint of telling rich and intricate stories with a simple melody and chord structure. It is difficult to consistently pull off this trick but Isbell manages to perform it with ease. If Southeastern embraced the concept of sobriety, Something More Than Free is addicted to being an adult. This is eloquently stated on the opener ‘If It Takes a Lifetime‘: ‘I’ve been working here Monday, it’ll be a year And I can’t recall a day when I didn’t wanna disappear But I keep on showing up hell-bent on growing up If it takes a lifetime’ Other album highlights are: 24 Frames – for those who don’t know, one second of video production (movies, television, etc.) is composed of 24 still frames of photography. The motif of this song is that your life can change in an instant. Once again, spirituality makes an appearance: ‘You thought God was an architect, now you know He’s something like a pipe bomb ready to blow And everything you built that’s all for show goes up in flames In twenty- four frames’ Flagship – this musical vignette tells the voyeuristic tale of a couple watching a much older couple in a diner. The older couple have nothing left to discover about each other and eat their dinner in silence. The younger couple vow to not let this happen to each other. My wife Megan likes this song because it references Hilton Head. Something More Than Free – the title track takes up the cause for the working class and champions the proletariat as they fight to exist in a world run by the bourgeois. This song could easily find a home on a Johnny Cash or Willie Nelson album. Again, spirituality makes a cameo: ‘When I get my reward my work will all be done And I will sit back in my chair beside the father and the son No more holes to fill and no more rocks to break And no more loading boxes on the trucks for someone else’s sake’ Speed Trap Town – perhaps the most concise story on an album full of concise stories. This song resonates with me for many reasons, particularly because I was raised in a very similar town – cops, football and rumors of adultery behind every corner. Anyone from northwestern Ohio can relate to the following stanza: ‘Well it’s a Thursday night but there’s a high school game Sneak a bottle up the bleachers and forget my name These 5A bastards run a shallow cross It’s a boy’s last dream and a man’s first loss‘ The Nashville Sound (2017) Released in June 2017 and clocking it at barely 40 minutes, this album is the most recent and shortest of the Handbook Trilogy. Southeastern embraced sobriety, Something More Than Free welcomes adulthood and The Nashville Sound finds joyful purpose in being a parent. Frankly, it is a riveting and insightful album that celebrates the joys and anxieties of parenting while opining the past, present and future of Music Row. This album also gives billing and focus to the 400 Unit, Isbell’s backing band. Comprised (mostly) of members from Isbell’s home state of Alabama, he and the 400 Unit certainly have a Springsteen/E Street vibe and rapport. Making an album and touring with a full band certainly seems like the right move after the stripped down nature of Something More Than Free. Last of My Kind – the John Prine influence is heavy on the album opener, both musically and lyrically. This tune explores what it means to feel alone and is an allegory for Isbell’s traditional country sound in a city that has been, at best, reticent to embrace the return of traditionalism: ‘I tried to go to college but I didn’t belong Everything I said was either funny or wrong They laughed at my boots, laughed at my jeans Laughed when they gave me amphetamines Left me alone in a bad part of town Thirty-six hours to come back down Am I the last of my kind? Cumberland Gap – a 1980s bar band rocker that celebrates rock’s roots. Simple, toe-tapping perfection. If We Were Vampires– this ballad is perhaps the most heartfelt love letter to a spouse in modern music history that is intensified by Isbell’s wife – and 400 Unit member – Amanda Shires playing fiddle and contributing backing vocals. Again, lyrically Isbell is at the top of his game AND everyone else’s game. It is really not a song that any review will do justice to. Just click on the song title already. Anxiety – this long rocker sees Isbell & Company dip their collective big toe into the southern jam band pool. At almost seven minutes (17% of the album’s length), it is the longest Isbell solo track that I am aware of and gives the 400 Unit a chance to showcase their chops. Something To Love – my favorite song on the album doubles as advice to Isbell’s new daughter, all the while reflecting on his own youth and mortality. Here are the lyrics – you should click on the link, it is worth it. My favorite lyrics from the entire album are on this track. My wife is sick of me singing this around the house: ‘I was born in a tiny southern town I grew up with all my family around We made music on the porch on Sunday nights Old men with old guitars, smoking Winston Lights’ Excuse me while I go smoke a Winston Light. Now, it is show time. So … I am a bit of a bad blogger. I completely missed Amanda Shires as the opener. She is my celebrity crush, and I instead stayed at 16-Bit with my friends Tom, Judd and Mark for a few pregame beverages. This is probably good news for the Isbell family, as I surely would have stolen her away. Sure, the drama would have made for a great album of new music, but I respect the sanctity of marriage (no matter who it is between), and the fact that the Isbells recently had a child together. I don’t need any bad Karma. Consider yourself lucky, Isbell. So, if you have never seen a show at The Ohio Theatre, you are missing out. Originally opened in 1928, The Ohio Theatre has been continuously open since and originally functioned as a movie house. The Ohio Theatre is ornate with an intricate ceiling and beautiful interior design. The acoustics have passed the test of time, and the only complaint I have is that the 3,000 seat capacity venue only seemed to be at 75% capacity. Shame on us, Columbus. As the band started into the extended rocker 24 Frames, I started thinking about the onstage/studio chemistry between Isbell and Shires. Undoubtedly, they are the First Couple of Country Music, but does that mean they are new Johnny and June? I then thought maybe they are closer to Paul and Linda, but Shires is MUCH too talented to be Linda (no disrespect intended). I thought I had the riddle solved when Bruce and Patti popped into my mind, especially as the band transitioned into Cumberland Gap, but then I realized I was missing the picture. I was simply watching a group of great musicians who were led by an artist who is as comfortable in his skin with them as without them. This situation doesn’t happen often, but when it does, it’s always great to see live. Isbell and Co. played 19 songs in total, all but three being from the albums reviewed for this entry. He and his backers transitioned between rocker and ballad seamlessly and each musician was given many opportunities to display their prowess with solos. Other highlights included the up tempo tunes Cumberland Gap, Flying Over Water and the ridiculously fun Super 8. Slower tempo was the name of the game at the end of the show with crowd favorites Cover Me Up and the encore If We Were Vampires (which I recorded and included for your viewing pleasure). All in all, this was the perfect venue for Isbell and friends to showcase their brand of Americana/Country Rock. At $50, our tickets were value filled, and we had a great time. In two years, Isbell (solo and with The 400 Unit) will not be playing venues this size, so if you get a chance to see them now, jump on it. ADDITIONS & SUBSTITUTIONS Dave Cobb should get a lot of credit for Isbell’s recent popularity, as he produced the three albums on this blog. Cobb is the hottest producer in the business and has also worked with Sturgill Simpson, Chris Stapleton, Jamey Johnson, Shooter Jennings and Zac Brown Band. Cobb is an essential part of the Retro Country Resurgence, and his country thanks him for it. The demo version of Elephant trades the lyrics ‘Harry Nilsson Songs’ for ‘Classic Country Songs’. I REALLY wish Isbell would have stuck with Harry Nilsson, because you know … Harry Nilsson. I think I will review Nilsson’s work on a menu with Gary Shandling’s work. Geniuses. The two songs from the show that I was unfamiliar with were Decoration Day and Never Gonna Change, both from Isbell’s time in Drive-By-Truckers. Do you have a favorite Drive-By-Truckers song? Go ahead and leave it in the comment section! Thanks! 2 thoughts on “The New Americana Music Handbook Trilogy and Jason Isbell & The 400 Unit at The Ohio Theatre” Jon Philbrick says: Awesome and spot-on! A Aron! You are a flat-out Isbell man! amwetli says: Thanks Jon! I’m glad you liked it! PreviousDeep Dish Pizza, Ben Folds & the Suburban Zombies of The Santa Clarita Diet NextSaying Goodbye to The Screaming Eagle of Soul and The Story Behind The Best Burger in Columbus	cc/2021-04/en_middle_0036.json.gz/line985
__label__cc	0.725006	0.274994	PRTG Network Monitor (PRTG) Wachtwoord achterhalen Voer uw gebruikersnaam in. Een nieuw wachtwoord wordt via email naar u verzonden. Login Naam Paessler Blog Storage performance monitoring with PRTG Storage performance monitoring should be a standard part of every intelligent monitoring solution as it can have a major, positive impact on daily business. Find out why PRTG Network Monitor is the ideal solution for storage performance monitoring below. Get Certified with Paessler: Become a PRTG Monitoring Expert! Have you heard about Paessler Certified Monitoring Expert? It is a technical certification that goes hand in hand with our technical PRTG training. Our focus through our training and certification program is to empower and give our partners and customers enough knowledge to properly plan, demonstrate, install and to provide first-level support. Also, as a Monitoring Expert you can help your customers to choose the best license for certain architecture and sensor strategy design. Track the health status of physical servers via iDRAC, iLO, iRMC and IMM We at Paessler are running heterogeneous network infrastructure powered by different physical servers such as Dell PowerEdge, HPE ProLiant, Fujitsu Primergy and IBM xSystem. Some of them are running as standalone servers and some are part of the cluster. One of the things I very much appreciate about managing my servers is the possibility to do it remotely, without even going to the server room and getting frozen, especially during the winter season. The remote management (hardware configuration, firmware upgrade or OS upgrade) can easily be done via management platforms/controllers/ports: iDRAC, iLO, iRMC and IMM – depending on the vendor. This was 2020 with PRTG. A review. Wow. 2020 was quite a hell ride for all of us! And I don't just mean us at Paessler, but really all of us. The whole planet experienced a rather exceptional year! You wouldn't believe what we've learned in one year after installing a PV system on our roof So, what happened to the photovoltaic system on our company roof? In short: It is still there. In a little longer: We couldn't be happier that we as a company are reducing our footprint on this earth by generating a significant portion of the electricity we use. We have been tracking our photovoltaic system, its output and our specific consumption for over a year now, and would like to give you a brief overview of our many insights. We released version 20.3.0 of our PRTG iOS and Android App I regularly tell you here about the changes in the PRTG versions and the new sensors and features the software provides. INSYS icom + Node-RED + PRTG = Monitoring OT data Frequent visitors, (that’s all of you, right?) may have noticed we’ve recently become very interested in technologies outside of traditional IT-focused monitoring. That’s not to say that we don’t still feel the love for all things “LAN, WAN, server & SAN”. But as most of us at Paessler are hardcore, self-confessed, uber-geeks, we just can’t resist the lure of shiny new tech to play with. That’s why many of our recent blog posts have an IoT or Industrial IoT focus. It’s not just blog posts either: our last few PRTG releases have included new sensor types, specifically for this exciting field – MQTT, Modbus and OPC-UA sensors are now all available in PRTG, and we’ve written extensively about enabling technologies that can help with the sometimes difficult task of merging the IT and OT worlds. PRTG 20.4.64 includes native sensors for Veeam and Azure PRTG Network Monitor release 20.4.64 is our 10th scheduled version this year, and it includes a lot of great stuff! PRTG 20.4.64 comes with three new sensor types, including the first one for Veeam, major improvements for our already delivered IoT sensors, some fixes and a bunch of other improvements. In more detail, you can be excited about our first native Veeam sensor that monitors the status of backup jobs, the Microsoft Azure Subscription Cost sensor, and the Dell EMC Unity Enclosure Health v2 sensor. So let's have a closer look into the new features. Clair Global uses PRTG to keep Coachella running smoothly At the recommendation of a client in 2010, Clair Global’s network architect Ben Harris downloaded Paessler’s free 100-sensor version of its PRTG Network Monitor software to monitor RealTime media networks events to provide peace of mind to their clients that the AV was running properly during events. When he moved into a larger networking role within the company, he said that Paessler’s PRTG Network Monitor was the clear choice from the price point and feature perspectives. “The interface is straightforward; the usability and price are great; and the flexibility to deploy custom plugins sold it for us. We haven’t looked back since.” When they could not find a company to help them deploy an enterprise-level temporary audio distribution network for the 2010 Vancouver Olympics, Clair Global decided to build it themselves and selected PRTG to monitor it. This kickstarted a new revenue stream for the company and a new department that specializes in rapidly deployable, portable and high-density IT networks to support concert tours, music festivals and sporting events – all monitored by PRTG. Now, several years later, Clair Global has significantly expanded its use of PRTG to benefit its clients. Monitoring MikroTik RouterOS is easy with PRTG MikroTik provides routing, switching and wireless equipment for all possible uses – from the customer location up to high-end data centers. Back in 1997, MikroTik developed a RouterOS software system that provides extensive stability, controls, and flexibility for all kinds of data interfaces and routing. Five years later, MikroTik created their own hardware called RouterBoard which today in combination with RouterOS supports all the necessary features for an ISP - routing, firewall, bandwidth management, wireless access point, backhaul link, hotspot gateway, VPN server, and more. Their products are not only used by ISPs, but also by individual users and companies for building data network infrastructures all around the world. INSYS icom smart gateways - giving you the edge With our recent focus on industrial IT, we've previously written about how PRTG and INSYS icom smart edge gateways can be used together. Now we want to go more into detail about a potential use case for getting data from the factory floor to PRTG using an INSYS icom gateway and Node-RED. But first, it makes sense to take a look at the INSYS part of the equation, which is what I'm going to do in this article. In a future post, I will take a look at how to get data into PRTG, so make sure you subscribe to our blog! The four commandments of Zoom It is increasingly obvious that online meetings on Zoom, Teams, et al. will be a permanent part of our business lives in the future – remote work is becoming a daily habit for many of us. We usually hold meetings and video calls to convey a message, and we can improve the effectiveness of this message with a good Zoom appearance. Well, you can as long as you are not one of those receiving/consuming parties in video conferences who turn off the camera most of the time... Turning old into new: Keeping an eye on your industrial IT environment with PRTG The production environment continues to prepare for the digital, more efficient future and in the sector this is very often paraphrased with the initially cryptic, but ultimately meaningful terms greenfield and brownfield. While a greenfield industrial plant is built "on a greenfield site", completely new and according to specific ideas, brownfield installations are those in which an existing plant is modernized. This article is part 2/2 of a short series on the topic of retrofitting. Here you can read part 1/2. 5 brand-new sensors! PRTG Network Monitor 20.4.63 released It was at the end of October when we released our PRTG Network Monitor Release 20.4.63 as a stable release. Some of you are probably already working with the latest version, all others can't wait to click on "update" after this article. :) But first things first. Introducing the new Modbus TCP sensor for PRTG In my last article I introduced the new OPC UA sensors in PRTG Network Monitor. Today I would like to introduce the new Modbus TCP Custom sensor, which has also been available since version 20.4.63. Compared to others, Modbus TCP is one of the most established protocols to enable communication between industrial machines and devices.	cc/2021-04/en_middle_0036.json.gz/line986
__label__wiki	0.966147	0.966147	The Late Show with Stephen Colbert - Season 4 Episode 155 Short Description Of Episode: Stephen Colbert took over as host, executive producer and writer of THE LATE SHOW on Tuesday, Sept. 8, 2015. The comedy-variety-talk show is broadcast five nights a week from the Ed Sullivan theater in New York. Episode: 155/842 eps Season 1 - The Late Show with Stephen Colbert 1 "George Clooney, Jeb Bush, Jon Batiste &... "Stephen welcomes George Clooney, Republican Presidential candidate Jeb Bush, plus a musical performance by Jon Batiste & Stay Human with special guests." 2 "Scarlett Johansson, Elon Musk, Kendrick... "Stephen welcomes actress Scarlett Johansson, Space X and Tesla Motors CEO Elon Musk, plus an interview with and musical performance by Kendrick Lamar." 3 "Vice President Joe Biden, Travis Kalani... "Stephen welcomes Vice President Joe Biden, Uber CEO Travis Kalanick, plus a musical performance by Toby Keith." 4 "Amy Schumer, Stephen King, Troubled Wat... "Stephen welcomes comedian Amy Schumer, author Stephen King, plus an interview with and performance by Troubled Waters." 5 "Emily Blunt, Justice Stephen Breyer, Th... "Stephen welcomes actress Emily Blunt, Justice Stephen Breyer, plus a performance by The Dead Weather." 6 "Tim Cook, Jake Gyllenhaal, Run The Jewe... "Stephen welcomes actor Jake Gyllenhaal, Apple CEO Tim Cook, plus a performance by Run the Jewels with TV on the Radio." 7 "Kevin Spacey, Carol Burnett, Abbi Jacob... "Stephen welcomes actor Kevin Spacey, TV legend Carol Burnett, plus a performance and interview with Willie Nelson and John Mellencamp." 8 "Trevor Noah, U.N. Ban Ki-Moon, Chris St... "Stephen welcomes Trevor Noah, United Nations Secretary-General Ban Ki-Moon, plus a musical performance by Chris Stapleton." 9 "Lupita Nyongu2019o, Sen. Bernie Sanders... "Stephen welcomes Lupita Nyong\u2019o, Senator Bernie Sanders, plus an interview with and performance by \u201cAn American in Paris\u2019\u201d Christopher Wheeldon, Robert Fairchild, and Leanne Cope" 10 "Stephen Curry, Sen. Ted Cruz, Don Henle... "Stephen welcomes NBA MVP Stephen Curry, Senator Ted Cruz, plus a musical performance by Don Henley." 11 "Donald Trump, Dr. Ernest Moniz, Raury" "Stephen welcomes Donald Trump, U.S. Secretary of Energy Dr. Ernest Moniz, plus a musical performance by Raury." 12 "Hugh Jackman, Hugh Evans, Sen. Elizabet... "Stephen welcomes actor Hugh Jackman with founder of the Global Poverty Projects Hugh Evans, Senator Elizabeth Warren, plus an interview with and musical performance by Pearl Jam." 13 "Andrew Sullivan, Maria Shriver, Jim Gaf... "Stephen welcomes author Andrew Sullivan, journalist and activist Maria Shriver, comedian Jim Gaffigan, Archbishop Thomas Wenski, plus a musical performance by the YMCA Jerusalem Youth Chorus and the Choir of St. Jean Baptiste." 14 "Malala Yousafzai, Kerry Washington, The... "Stephen welcome Pakistani activist Malala Yousadzai, American actress Kerry Washington, plus Dan Auerbach's band The Arcs." 15 "First Lady Michelle Obama, John Legend" "Stephen welcomes First Lady Michelle Obama and singer John Legend." 16 "Ellen Page, Jesse Eisenberg, Dominic Wi... "Stephen welcomes actress Ellen Page, actor Jesse Eisenberg, plus inventor and designer Dominic Wilcox." 17 "John Oliver, Evan Spiegel, Bill Withers... "Stephen welcomes John Oliver, founder of Snapchat Evan Spiegel, plus an interview with singer-songwriter Bill Withers and a performance by Ed Sheeran." 18 "John Kerry, Claire Danes, PewDiePie" "Stephen welcomes Secretary of State John Kerry, actress Claire Danes, and YouTube comedian PewDiePie." 19 "Morgan Freeman, Ruth Wilson, Sean Murra... "Stephen welcomes actor Morgan Freeman, executive producer of the CBS series \u201cMadam Secretary,\u201d actress Ruth Wilson, plus an interview with and demonstration by Hello Games founder Sean Murray." 20 "Senator John McCain, Yo-Yo Ma, Misty Co... "Stephen welcomes Senator John McCain, special guest Yo-Yo Ma, plus an interview with and performance by ballerina Misty Copeland." 21 "Bill Clinton, Billy Eichner, Florence &... "Stephen welcomes Former President Bill Clinton, comic Billy Eichner, plus a musical performance by Florence and the Machine." 22 "Gina Rodriguez, Ben Bernanke, Tame Impa... "Stephen welcomes actress Gina Rodriguez, economist Ben Bernanke, plus musical guest Tame Impala." 23 "Cate Blanchett, Brian Chesky, Dartmouth... "Stephen welcomes actress Cate Blanchett, Airbnb CEO Brian Chesky, and Dartmouth's Robotic MVP." 24 "James Corden, Shane Smith, Halsey" "Stephen welcomes TV host James Corden, Vice Media CEO Shane Smith, plus a musical performance by Halsey." 25 "Carey Mulligan, Elvis Costello, Darlene... "Stephen welcomes actress Carey Mulligan, musician Elvis Costello, plus a musical performance by Darlene Love." 26 "Sarah Silverman, Elijah Wood, Symphony ... "Stephen welcomes actress Sarah Silverman, actor Elijah Wood, plus a musical performance by Legends of Zelda: Symphony of the Goddesses." 27 "Jack Black, Nick Woodman, Michelle Dorr... "Stephen welcomes actor Jack Black, CEO of GoPro Nick Woodman, plus a dance performance by Michelle Dorrance." 28 "Oprah Winfrey, Joseph Fink, Jeffrey Cra... "Stephen welcomes media proprietor Oprah Winfrey, podcast creators Joseph Fink and Jeffrey Cranor, plus a musical performance by Judith Hill." 29 "Jimmy Kimmel, the cast and director of ... "Stephen welcomes TV host Jimmy Kimmel, \u201cCrimson Peak\u201d cast members Jessica Chastain, Tom Hiddleston, and Mia Wasikowska, with director Guillermo Del Toro, a performance by Beach House, plus Vance Joy performs with Jon Batiste & Stay Human." 30 "Sienna Miller, Melissa Benoist, Chance ... "Stephen welcomes actress Sienna Miller, \u201cSupergirl\u201d Melissa Benoist, plus a performance by Chance the Rapper." 31 "Hillary Clinton, Anthony Bourdain, Carr... "Stephen welcomes presidential hopeful Hillary Clinton, chef Anthony Bourdain, author Carrie Brownstein, plus Lianne La Havas performs with Jon Batiste & Stay Human." 32 "Julianna Margulies, Jonathan Franzen, A... "Stephen welcomes actress Julianna Margulies, author Jonathan Franzen, plus a musical performance by Alabama Shakes." 33 "Seth MacFarlane, Neil DeGrasse Tyson" "Stephen welcomes musical guest Seth MacFarlane and astrophysicist Neil DeGrasse Tyson." 34 "Charlie Rose, Stacy Schiff, Ghost" "Stephen welcomes \u201cCBS This Morning\u201d co-host Charlie Rose, author Stacy Schiff, a musical performance by Ghost, plus the Zombies sit in with Jon Batiste & Stay Human." 35 "Allison Janney, Colin Quinn, Margaret C... "Stephen welcomes actress Allison Janney from the CBS comedy \u201cMom,\u201d comedian Colin Quinn, plus an interview with and performance by comic Margaret Cho." 36 "Antonio Banderas, Reed Hastings, John I... "Stephen welcomes actor Antonio Banderas, Netflix CEO Reed Hastings, and author John Irving." 37 "Daniel Craig, Elizabeth Gilbert, Dr. Eu... "Stephen welcomes actor Daniel Craig, author Elizabeth Gilbert, plus an interview with and demonstration by Dr. Eugenia Cheng." 38 "Bryan Cranston, Shamir" "Stephen welcomes actor Bryan Cranston, plus a musical performance by Shamir." 39 "Whoopi Goldberg, John Kasich, Glen Hans... "Stephen welcomes TV host Whoopi Goldberg, GOP candidate John Kasich, plus a musical performance by Glen Hansard." 40 "Ethan Hawke, Claire McCaskill, Amy Klob... "Stephen welcomes actor Ethan Hawke, Senator Claire McCaskill & Senator Amy Klobuchar, plus a musical performance by Nathaniel Rateliff & The Night Sweats." 41 "Aziz Ansari, Shonda Rhimes, Bruce Campb... "Stephen welcomes comic Aziz Ansari, TV producer Shonda Rhimes, and actors Bruce Campbell & Lucy Lawless." 42 "Viola Davis, Brian Greene, George Ezra" "Stephen welcomes actress Viola Davis, physicist Brian Greene, plus a musical performance by George Ezra." 43 "Jennifer Connelly, Judd Apatow, The Int... "Stephen welcomes actress Jennifer Connelly, director Judd Apatow, plus a musical performance by The Internet." 44 "Mark Ruffalo, John Cleese, Michael Flat... "Stephen welcomes actor Mark Ruffalo, actor John Cleese, plus an interview with and performance by Michael Flatley." 45 "Bill Maher, Florent Groberg, Shepard Fa... "Stephen welcomes Bill Maher, Medal of Honor Recipient Army Captain Florent Groberg, author Shepard Fairey, plus a special performance by The Acro-Cats." 46 "Julianne Moore, Burt Reynolds, Public I... "Stephen welcomes actress Julianne Moore, actor Burt Reynolds, a musical performance by Public Image Ltd, plus CeeLo Green sits in with Jon Batiste & Stay Human." 47 "Sharon Stone, Justin Theroux, James Tay... "Stephen welcomes actress Sharon Stone, actor Justin Theroux, plus a musical performance by James Taylor." 48 "Jane Fonda, Andrew Lloyd Webber" "Stephen welcomes actress Jane Fonda, an interview with and performance by Andrew Lloyd Webber, plus young guitarist Brandon Niederauer sits in with Jon Batiste & Stay Human." 49 "Michael Caine, Larry Wilmore, Boots" "Stephen welcomes actor Michael Caine, comic Larry Wilmore, a musical performance by Boots, plus Vulfpeck sits in with Jon Batiste & Stay Human." 50 "Sylvester Stallone, Ted Koppel, My Morn... "Stephen welcomes actor Sylvester Stallone, author Ted Koppel, plus a musical performance by My Morning Jacket." 51 "Spike Lee, Andy Cohen, Carly Simon" "Stephen welcomes director Spike Lee, Bravo's Andy Cohen, plus a musical performance by Carly Simon." 52 "Gloria Estefan, Eric Greitens, Jake Woo... "Stephen welcomes musician Gloria Estefan, Navy SEAL Eric Greitens with former Marine Sgt. Jake Wood, and chef Daniel Boulud." 53 "Steve Carell, Jennifer Hudson" "Stephen welcomes actor Steve Carell, plus an interview with and performance by Jennifer Hudson from the Broadway production of \u201cThe Color Purple.\u201d" 54 "Marion Cotillard, George Saunders, Joan... "Stephen welcomes actress Marion Cotillard, author George Saunders, plus a musical performance by Joanna Newsom." 55 "Michelle Dockery, Hugh Bonneville, Alle... "Stephen welcomes \u201cDownton Abbey\u201d cast members Michelle Dockery, Hugh Bonneville, and Allen Leech, director Adam McKay, plus a musical performance by Kurt Vile." 56 "Bruce Willis, Michael Lewis, Lizzo" "Stephen welcomes actor Bruce Willis, author Michael Lewis, plus a musical performance by Lizzo." 57 "Lin-Manuel Miranda, Ike Barinholtz, Sha... "Stephen welcomes playwright Lin-Manuel Miranda, actor Ike Barinholtz, plus a musical performance by Sharon Jones & The Dap-Kings." 58 "Jennifer Lawrence, Doris Kearns Goodwin... "Stephen welcomes actress Jennifer Lawrence, historian Doris Kearns Goodwin, plus a musical performance by Sleater-Kinney." 59 "Quentin Tarantino, Jonathan Groff, Sque... "Stephen welcomes director Quentin Tarantino, actor Jonathan Groff, plus a musical performance by Squeeze." 60 "Robert De Niro, Daniel Gilbert, Henry R... "Stephen welcomes actor Robert De Niro, author Daniel Gilbert, plus an interview with and comical music performance by Henry Rollins." 61 "Michael Moore, Samantha Power, Michael ... "Stephen welcomes director Michael Moore, US Ambassador to the UN Samantha Power, actor Michael C. Hall, plus a musical performance from the cast of the musical \u201cLazarus.\u201d" 62 "Mandy Patinkin, Kayvon Beykpour, Leon B... "Stephen welcomes actor Mandy Patinkin, Periscope CEO Kayvon Beykpour, plus a musical performance by Leon Bridges." 63 "Samuel L. Jackson, Olivia Hallisey" "Stephen welcomes actor Samuel L. Jackson, and Google Science Fair Winner Olivia Hallisey." 64 "John Krasinski, Killer Mike, George Chu... "Stephen welcomes actor John Krasinski, Hip Hop artist Killer Mike, geneticist George Church, and a musical performance by Foals." 65 "Jerry Seinfeld, Senator Rand Paul, Andr... "Stephen welcomes a stand-up performance by and interview with Jerry Seinfeld, Senator Rand Paul, plus a musical performance by Andra Day." 66 "Damian Lewis, America Ferrera, FloydLit... "Stephen welcomes actor Damian Lewis, actress America Ferrera, plus a performance by FloydLittle's Double Dutch team." 67 "Matthew Broderick, Sarah Parcak, Kacey ... "Stephen welcomes actor Matthew Broderick, space archaeologist Sarah Parcak, plus a musical performance by Kacey Musgraves." 68 "Jane Lynch, Sec. Julian Castro, EL VY" "Stephen welcomes actress Jane Lynch, from the the CBS comedy series \"Angel From Hell\"; Secretary of the U.S. Department of Housing and Urban Development Julian Castro, and a musical performance by EL VY." 69 "Saoirse Ronan, Jeremy Stoppelman, Laura... "Stephen welcomes actress Saoirse Ronan, CEO of Yelp Jeremy Stoppelman, \"Making a Murderer\" Filmmakers Laura Ricciardi and Moira Demos, and a musical performance by James Bay." 70 "Paul Giamatti, Guerrilla Girls, J.B. Ma... "Stephen welcomes actor Paul Giamatti, artists Guerrilla Girls, and professional bull rider J.B. Mauney." 71 "Olivia Munn, T.J. Miller, Father John M... "Stephen welcomes actress Olivia Munn, T.J Miller, and a musical performance by Father John Misty." 72 "Scott Kelly, Abby Wambach, Maria Bamfor... "Stephen welcomes astronaut Scott Kelly, U.S. Women's Soccer star Abby Wambach, and comedian Maria Bamford." 73 "Patricia Heaton, Quincy Jones, Deray Mc... "Stephen welcomes Patricia Heaton, Quincy Jones, Civil Rights Activist DeRay McKesson, and a musical performance by Grace." 74 "Charlie Day, Colin Hanks, Margo Price" "Stephen welcomes Charlie Day, Colin Hanks from the CBS comedy series \"Life in Pieces,\" and a musical performance by Margo Price." 75 "James Spader, Brandon Marshall, Sarah K... "Stephen welcomes actor James Spader, New York Jets Wide Receiver Brandon Marshall, host and Executive Producer of \"Serial\" Podcast Sarah Koenig, and Rev Run." 76 "Christian Slater, Josh Radnor, Iggy Pop... "Stephen welcomes actors Christian Slater and Josh Radnor and musician Iggy Pop." 77 "Steven Tyler, Gaby Hoffmann, Lu00e5psle... 78 "Donald Rumsfeld, Russell Westbrook, Jac... "Stephen welcomes Secretary Donald Rumsfeld, Oklahoma City Thunder Point Guard Russell Westbrook, and a musical performance by Jackson Browne." 79 "Laurence Fishburne, Michael Novacek, La... "Stephen welcomes Laurence Fishburne, Michael Novacek, and a musical performance by Lake Street Dive." 80 "Chris Pine, Danielle Brooks, Jonah Reid... "Stephen welcomes Chris Pine, actress Danielle Brooks, Columbia University student Jonah Reider, and a musical performance by Baauer." 81 "Josh Brolin, John Dickerson, Erin Brock... "Stephen welcomes Josh Brolin, John Dickers, host of CBS News's \"Face the Nation\"; Environmental Activist Erin Brockovich, and a musical performance by Aubrie Sellers." 82 "John Travolta, Courtney B. Vance, Amy C... "Stephen welcomes John Travolta and Courtney B. Vance, author Amy Cuddy, and a musical performance John Moreland." 83 "David Schwimmer, Joel Osteen, M. Ward" "Stephen welcomes David Schwimmer, Pastor Joel Osteen, and a musical performance by M. Ward." 84 "Dr. Phil McGraw, Mark & Jay Duplass, Mi... "Stephen welcomes Dr. Phil, creators of \"Togetherness\" Mark and Jay Duplass, author Michael Eric Dyson, and a musical performance by Anderson .Paak and the Free Nationals." 85 "Michael Strahan, Samantha Bee, Wilco" "Stephen welcomes Michael Strahan, Samantha Bee, and a musical performance by Wilco." 86 "Bobby Cannavale, Donny Deutsch, Charles... "Stephen welcomes Bobby Cannavale; Advertising executive Donny Deutsch, and a musical performance by Charles Kelley." 87 "Tina Fey and Margot Robbie, Will Ferrel... "Stephen welcomes Tina Fey and Margot Robbie, Will Ferrell, Megyn Kelly, and Key & Peele." 88 "Bill O'Reilly, Eddie George, Macklemore... "Stephen welcomes Bill O'Reilly, former NFL star Eddie George, and a musical performance by Macklemore and Ryan Lewis." 89 "Olivia Wilde, Christiane Amanpour, Jon ... "Stephen welcomes Olivia Wilde, Christiane Amanpour, and a musical performance by Jon Batiste & Stay Human." 90 "Ben Stiller, Bernie Sanders, Tao: Seven... "Stephen welcomes Ben Stiller, Senator Bernie Sanders, and a performance by Tao: Seventeen Samurai." 91 "Kelsey Grammer, Fred Armisen, Sarah McD... "Stephen welcomes Kelsey Grammer, Fred Armisen, \u201cPlayboy\u201d cover girl Sarah McDaniel, and a musical performance by Ty Segall and the Muggers." 92 "Craig Ferguson, Senator Cory Booker, Sc... "Stephen welcomes Craig Ferguson, Senator Cory Booker, and World Darts Champion Scott Waites." 93 "Eva Longoria, Abbi Jacobson & Ilana Gla... "Stephen welcomes Eva Longoria, Abbi Jacobson & ilana Glazer, and a musical performance by Lucinda Williams." 94 "Kate Hudson, Governor John Kasich, Cour... "Stephen welcomes Kate Hudson, Governor John Kasich, and a musical performance by Courtney Barnett." 95 "Tea Leoni, Amanda Peet, Triumph the Ins... "Stephen welcomes actress Tea Leoni from the CBS drama series \"Madam Secretary\", Amanda Peet, and Triumph the Insult Comic Dog." 96 "Chelsea Handler, Zosia Mamet, The Lumin... "Stephen welcomes Chelsea Handler, Zosia Mamet, and a musical performance by The Lumineers." 97 "Casey Affleck, Richard Dreyfuss, Mavis ... "Stephen welcomes Casey Affleck, Richard Dreyfuss, and an interview with and musical performance by Mavis Staples." 98 "Debra Messing, Zachary Quinto, Violent ... "Stephen welcomes Debra Messing, Zachary Quinto, and a musical performance by Violent Femmes." 99 "Adrien Brody, Danai Gurira, Brian Green... "Stephen welcomes Adrien Brody, actress Danai Gurira from \"The Walking Dead,\" and Physicist Brian Greene." 100 "Tim Daly, Graham Nash, Jason Isbell" "Stephen welcomes Tim Daly from the CBS drama series \u201cMadam Secretary,\" Singer-songwriter Graham Nash, and a musical performance by Jason Isbell ." 101 "Spike Jonze, Jeffrey Dean Morgan, Jack ... "Stephen welcomes Director Spike Jonze, Jeffrey Dean Morgan from the CBS drama series \u201cThe Good Wife\u201d and a musical performance by Jack Garratt." 102 "Chrissy Teigen, Mike Birbiglia, Adam Sa... "Stephen welcomes Chrissy Teigen, comedian Mike Birbiglia, and Adam Savage of \u201cMythBusters.\"" 103 "Octavia Spencer, John Stamos, Bob Saget... "Stephen welcomes Octavia Spencer, the cast of \u201cFuller House\u201d: John Stamos, Bob Saget and Dave Coulier, and a musical performance by Lucius." 104 "Christopher Meloni, Mary Elizabeth Wins... "Stephen welcomes Christopher Meloni, actress Mary Elizabeth Winstead;, Medal of Honor Recipient Edward Byers, and a musical performance by Ray LaMontagne." 105 "Will Arnett, Charles Barkley, Max Green... "Stephen welcomes Will Arnett, Charles Barkley, and actor Max Greenfield." 106 "Helen Mirren, J.J. Abrams, DMAu2019S" "Stephen welcomes Helen Mirren, J.J. Abrams, and a musical performance by DMA'S." 107 "Sally Field, Jerrod Carmichael, Esperan... "Stephen welcomes Sally Field, Jerrod Carmichael, and a musical performance by Esperanza Spalding." 108 "Anna Kendrick, Loretta Lynch, Brian Fal... "Stephen welcomes Anna Kendrick, U.S. Attorney General Loretta Lynch, and a musical performance by Brian Fallon." 109 "Jeff Daniels, Mary Elizabeth Winstead, ... "Stephen welcomes Jeff Daniels, actress Mary Elizabeth Winstead, and Audra McDonald." 110 "John Oliver, Jordan Spieth, New Order" "Stephen welcomes John Oliver, World #1 Golfer Jordan Spieth, and a musical performance by New Order." 111 "Steve Martin & Edie Brickell, Shirley M... "Stephen welcomes Steve Martin & Edie Brickell, Shirley MacLaine, and an interview with Los Angeles Philharmonic conductor Gustavo Dudamel and performance with orchestra." 112 "Theo James, Jussie Smollett, Laurie And... "Stephen welcomes Theo James, Jussie Smollett, and a musical performance by Laurie Anderson." 113 "William H. Macy, Melissa Rauch, Isaac M... "Stephen welcomes William H. Macy, Melissa Rauch, and Isaac Mizrahi." 114 "Tom Hiddleston, Laura Benant, Frightene... "Stephen welcomes Tom Hiddleston, Laura Benanti from the CBS drama series \"Supergirl\" and a musical performance by Frightened Rabbit." 115 "Adam Driver, Rachel Bloom, Savages" "Stephen welcomes Adam Driver, Rachel Bloom, and a musical performance by Savages." 116 "Eric Stonestreet, Jason Jones, Elizabet... "Stephen welcomes Eric Stonestreet, Jason Jones, and Senator Elizabeth Warren." 117 "Sarah Paulson, Tatiana Maslany, Wynton ... "Stephen welcomes Sarah Paulson, Tatiana Maslany, and interview with and musical performance by Wynton Marsalis, Lil Buck, and Jared Grimes." 118 "Steve Buscemi, Benjamin Walker, Broadwa... "Stephen welcomes Steve Buscemi, actor Benjamin Walker, and a performance by the cast of Broadway's \"American Psycho.\"" 119 "Matthew Perry, Nick Offerman, Explosion... "Stephen welcomes Matthew Perry from the CBS comedy series \"The Odd Couple,\" Nick Offerman, a musical performance by Explosions In The Sky, and Parliament-Funkadelic sitting in with Jon Batiste and Stay Human." 120 "Melissa McCarthy, Ben Falcone, Arianna ... "Stephen welcomes Melissa McCarthy & Ben Falcone, Arianna Huffington, and a musical performance by BABYMETAL." 121 "Anna Kendrick, Sam Rockwell, David Duch... "Stephen welcomes Anna Kendrick & Sam Rockwell, David Duchovny, and a musical performance by Autolux." 122 "Mindy Kaling, Tituss Burgess, Ken Burns... "Stephen welcomes Mindy Kaling, Tituss Burgess, and filmmaker Ken Burns." 123 "Hillary Clinton, Jesse Tyler Ferguson, ... "Stephen welcomes Hillary Clinton, Jesse Tyler Ferguson, Katharine McPhee from the CBS drama series \"Scorpion,\" a musical performance by Sturgill Simpson, and Wayne Shorter sitting in with Jon Batiste and Stay Human." 124 "Rep. Paul Ryan, Kevin Spacey, Thomas Mi... "Stephen welcomes Kevin Spacey, actor Thomas Middleditch, a musical performance by The Flaming Lips, and Arturo Sandoval sitting in with Jon Batiste and Stay Human." 125 "Dennis Quaid, Matt Walsh, Charles Bradl... "Stephen welcomes Dennis Quaid, actor Matt Walsh, a musical performance by Charles Bradley, and Tootie & Jimmy Heath sitting in with Jon Batiste and Stay Human." 126 "Tom Hanks, Leslie Odom Jr., The Strumbe... "Stephen welcomes Tom Hanks, Leslie Odom Jr., a musical performance by The Strumbellas, and Roy Haynes sitting in with Jon Batiste and Stay Human." 127 "Julia Louis-Dreyfus, Nikolaj Coster-Wal... "Stephen welcomes Julia Louis-Dreyfus, Nikolaj Coster-Waldau, and comedian Sam Morril." 128 "Michelle Williams, Eddie Huang, Bob Mou... "Stephen welcomes Michelle Williams, Viceland's Eddie Huang, and a musical performance by Bob Mould." 129 "J.K. Simmons, Jane Krakowski, Chris Wal... "Stephen welcomes J.K. Simmons, Jane Krakowski, and Chris Wallace." 130 "Susan Sarandon, David Tennant, Catfish ... "Stephen welcomes Susan Sarandon, actor David Tennant, and a musical performance by Catfish and The Bottlemen." 131 "Julianna Margulies, Christine Baranski,... "Stephen welcomes the cast of the CBS drama series \"The Good Wife\": Julianna Margulies, Christine Baranski, and Matt Czuchry, also Hank Azaria, and Nike Co-Founder and Chairman Phil Knight." 132 "Anderson Cooper, Mark Feuerstein, Gwen ... "Stephen welcomes Anderson Cooper, Mark Feuerstein and a musical performance by Gwen Stefani." 133 "Bill O'Reilly, Morris Chestnut, Deerhun... "Stephen welcomes Bill O'Reilly, Morris Chestnut, and a musical performance by Deerhunter." 134 "Dakota Johnson, Sebastian Stan, Lukas N... "Stephen welcomes Dakota Johnson, Sebastian Stan, and a musical performance by Lukas Nelson & Promise of the Real." 135 "Anthony Mackie, Rob Reiner, Maxwell" "Stephen welcomes Anthony Mackie, Rob Reiner, and a musical performance by Maxwell." 136 "Judge Judy, Zac Posen, W. Kamau Bell" "Stephen welcomes Judge Judy, Zac Posen and W. Kamau Bell." 137 "Lily Tomlin, Kumail Nanjiani, Ryan Hami... "Stephen welcomes Lily Tomlin, actor Kumail Nanjiani, and a performance by stand-up comedian Ryan Hamilton." 138 "Kaley Cuoco, Dan Savage, The National" "Stephen welcomes Kaley Cuoco from the CBS comedy series \"The Big Bang Theory,\" author and podcast host Dan Savage, and a musical performance by The National." 139 "Chloe Grace Moretz, Katie Couric, Charl... 140 "Kate Beckinsale, B.J. Novak, Desiigner" 141 "Ryan Gosling, Russell Crowe, Jessie Mue... 142 "Matt Bomer, Zach Woods, Nick Griffin" 143 "Episode 143" 202 "Actress Anna Gunn; journalist John Dick... "Actress Anna Gunn; journalist John Dickerson; inventor Simone Giertz." 1 "Maggie Gyllenhaal/Graham Norton/Lukas N... "Actress Maggie Gyllenhaal (The Deuce (2017)); comic Graham Norton (The Graham Norton Show (2007)); Lukas Nelson and Lukas Nelson & Promise of the Real perform." 2 "Liev Schreiber/Joe Buck/Sonequa Martin-... "Actor Liev Schreiber (Ray Donovan (2013) and Goon: Last of the Enforcers (2017)); sportscaster Joe Buck; actress Sonequa Martin-Green (The Walking Dead (2010)); Sheila E. performs." 3 "Bernie Sanders/Caitriona Balfe/The Nati... "Sen. Bernie Sanders (Ind-Vt.); actress Caitriona Balfe (Outlander (2014)); The National perform." 5 "THE LATE SHOW's Second Anniversary Spec... "The Late Show's second anniversary special." 6 "Hillary Clinton/Emma Stone" "Former Secretary of State Hillary Clinton; actress Emma Stone (Battle of the Sexes (2017))." 7 "Jeff Bridges/Jeff Flake/Miguel" "Actor Jeff Bridges (Kingsman: The Golden Circle (2017)); Sen. Jeff Flake (R-Ariz.) (book, \"Conscience of a Conservative\"); Miguel performs." 8 "Jim Parsons/Pamela Adlon/The Killers" "Actor Jim Parsons (The Big Bang Theory (2007)); actress Pamela Adlon (Better Things (2016)); The Killers perform." 9 "Bobby Moynihan/Tatiana Maslany" "Actor Bobby Moynihan (Me, Myself and I (2017)); actress Tatiana Maslany (Stronger (2017))." 10 "Sterling K. Brown/Chance The Rapper" "Actor Sterling K. Brown (This Is Us (2016) and Marshall (2017)); Chance the Rapper performs." 11 "Sofia Vergara/David Boreanaz/Ken Burns" "Actress Sof\u00eda Vergara (Modern Family (2009)); actor David Boreanaz (Bones (2005)); documentarian Ken Burns (The Vietnam War (2017))." 12 "Nick Kroll/Michael Bloomberg/Tim Heidec... "Actor Nick Kroll (Big Mouth (2017) and The House (2017)); businessman Michael Bloomberg; comics Tim Heidecker and Eric Wareheim." 13 "Steve Martin/Mark Feuerstein/Steep Cany... "Actor Steve Martin; actor Mark Feuerstein (9JKL (2017)); Steve Martin performs with The Steep Canyon Rangers." 14 "Jerry Seinfield" "Comic Jerry Seinfeld (Jerry Before Seinfeld (2017))." 15 "Pierce Brosnan/Jason Alexander/Ta-Nehis... "Actor Pierce Brosnan (The Foreigner (2017)); actor Jason Alexander (Hit the Road (2017)); author Ta-Nehisi Coates." 16 "Michael Weatherly/Natasha Leggero/Paul ... "Actor Michael Weatherly (Bull (2016)); actress Natasha Leggero (Dice (2016)); Paul Weller performs." 17 "Kerry Washington/Russell Brand/St. Vinc... "Actress Kerry Washington (Scandal (2012)); author Russell Brand (book, \"Recovery: Freedom From Our Addictions\"); St. Vincent performs." 18 "Morgan Freeman/Grace Gummer/Nathan Maci... "Actor Morgan Freeman (Just Getting Started (2017)); actress Grace Gummer (Mr. Robot (2015)); comic Nathan Macintosh." 19 "Kathy Bates" "Actress Kathy Bates (Disjointed (2017));" 20 "Jackie Chan/Tig Notaro/Bob Schieffer/Tr... "Actor Jackie Chan (The Foreigner (2017)); comic Tig Notaro (One Mississippi (2015)); Bob Schieffer (CBS News); Trombone Shorty sits in with Jonathan Batiste and Stay Human." 21 "Tracee Ellis Ross/Luke Evans/Jade Bird" "Actress Tracee Ellis Ross (Black-ish (2014)); actor Luke Evans (Professor Marston and the Wonder Women (2017)); Jade Bird performs." 22 "Andrew Garfield/Tracy Ullman/Wolf Parad... "Actor Andrew Garfield (Breathe (2017)); actress Tracey Ullman (Tracey Breaks the News (2017)); Wolf Parade perform." 23 "Bill Murray/Claire Foy/Jan Vogler" "Actor Bill Murray; actress Claire Foy (Breathe (2017) and The Crown (2016)); Bill Murray performs with Jan Vogler and Friends." 24 "Conan O'Brien/Tig Notaro" "TV talk show host Conan O'Brien (Conan (2010)); comic Tig Notaro (One Mississippi (2015))." 25 "Anna Faris/Amy Sedaris/Tyminski" "Actress Anna Faris (Mom (2013)); actress Amy Sedaris (BoJack Horseman (2014)); Dan Tyminski performs." 26 "Jake Tapper/Shemar Moore/Khalid" "Journalist Jake Tapper (The Lead with Jake Tapper (2013)); actor Shemar Moore (S.W.A.T. (2017)); Khalid performs." 27 "Hugh Laurie, Gretchen Carlson, Adam Sav... "Actor Hugh Laurie (Chance (2016)); TV personality Gretchen Carlson (book, \"Be Fierce: Stop Harassment and Take Your Power Back\"); TV personality Adam Savage (MythBusters (2003)); YouTube personality Michael Stevens." 28 "Julianne Moore/Jermaine Fowler/Fleet Fo... "Actress Julianne Moore (Suburbicon (2017)); actor Jermaine Fowler (Superior Donuts (2017)); Fleet Foxes perform." 29 "Dr. Phil McGraw/Scott Kelly" "Dr. Phil McGraw (Dr. Phil (2002)); retired astronaut Scott Kelly." 30 "Billy Eichner/Anna Camp/Weezer" "Actor Billy Eichner (Billy on the Street with Billy Eichner (2011)); actress Anna Camp (Pitch Perfect 3 (2017)); Weezer perform." 31 "Mark Ruffalo/Chris Matthews/Gilbert Got... "Actor Mark Ruffalo (Thor: Ragnarok (2017)); Chris Matthews (Hardball with Chris Matthews (1997)); actor Gilbert Gottfried; Thundercat sit in with Jonathan Batiste and Stay Human." 32 "Nicole Kidman/Jonathan Groff/Walter Isa... "Actress Nicole Kidman (The Killing of a Sacred Deer (2017)); actor Jonathan Groff (Mindhunter (2017)); author Walter Isaacson;" 33 "Whoopi Goldberg/Kathryn Hahn/Courtney B... "Whoopi Goldberg (The View (1997)); actress Kathryn Hahn (A Bad Moms Christmas (2017)); Courtney Barnett and Kurt Vile perform." 34 "Ronan Farrow/Walter Isaacson/Kelsea Bal... "Journalist Ronan Farrow (Ronan Farrow Daily (2014)); author Walter Isaacson; Kelsea Ballerini performs." 35 "Josh Gad/Lawrence O'Donnell/Derek DelGa... "Actor Josh Gad (Murder on the Orient Express (2017)); TV host Lawrence O'Donnell (The Last Word with Lawrence O'Donnell (2010)); magician Derek DelGaudio." 36 "Jason Segel/Jeff Fager/Lesley Stahl/Mav... "Actor Jason Segel; producer Jeff Fager and journalist Lesley Stahl (60 Minutes (1968)); Mavis Staples performs." 37 "Norman Reedus/Sean Astin/Pat McGann" "Actor Norman Reedus (The Walking Dead (2010)); actor Sean Astin (Stranger Things (2016) and Teenage Mutant Ninja Turtles (2012)); comic Pat McGann performs." 38 "William H. Macy/Jay Pharoah/Rationale" "Louis C.K.; actor Jay Pharoah (White Famous (2017)); Rationale perform." 39 "John Mulaney/Jason Segel" "Comic John Mulaney (Big Mouth (2017)); actor Jason Segel." 40 "Joe Biden/Elton John" "Former Vice President Joe Biden (book, \"Promise Me, Dad: A Year of Hope, Hardship, and Purpose\"); Elton John performs." 41 "Tyler Perry/Anthony Atamanuik/John Avlo... "Tyler Perry (The Star (2017)); actor Anthony Atamanuik (Tracey Breaks the News (2017)); journalist John Avlon." 42 "Jordan Peele/Alia Shawkat/Paul Mecurio" "Actor Jordan Peele (\"Get Out\"); actress Alia Shawkat (\"Arrested Development\" and \"Search Party\"); comic Paul Mecurio performs." 43 "Ben Affleck/Greta Gerwig/Dead & Company... "Actor Ben Affleck (\"Justice League\" (2017)); writer\/director Greta Gerwig (\"Lady Bird\" (2017)); Dead and Company perform." 44 "Norah O'Donnell/Dead & Company" "TV hostess Norah O'Donnell (CBS This Morning (1992)); Dead & Company perform." 45 "Elizabeth Warren/Desus & Mero/Vic Mensa... "Sen. Elizabeth Warren (D-Mass); comics Desus Nice and The Kid Mero; Vic Mensa performs." 46 "Gayle King/Daveed Diggs/Gregory Porter" "TV personality Gayle King (CBS This Morning (1992)); actor Daveed Diggs (Wonder (2017)); Gregory Porter performs." 47 "John Leguizamo/Elton John" "Actor John Leguizamo (play, \"Latin History for Morons\"); Elton John performs." 48 "Justin Timberlake/Carmen Yulu00edn Cruz... "Actor Justin Timberlake; Carmen Yulin Cruz, mayor of San Juan, Puerto Rico." 49 "Kate Winslet, Laura Benanti, Wolf Alice... "Actress Kate Winslet (Wonder Wheel (2017)); actress Laura Benanti (The Detour (2016)); Wolf Alice perform." 50 "Carol Burnett, Lewis Black" "Actress Carol Burnett (The Carol Burnett 50th Anniversary Special (2017)); comic Lewis Black (The President Show: Joe Cirincione (2017))." 51 "Billy Bush, Gwendoline Christie" "TV personality Billy Bush; actress Gwendoline Christie (Star Wars: The Last Jedi (2017));" 52 "Saoirse Ronan, Van Jones, Michelle Wolf... "Actress Saoirse Ronan (Lady Bird); author Van Jones; comic Michelle Wolf performs." 53 "Ed Helms, Christopher Jackson, Bleacher... "Actor Ed Helms (Father Figures (2017)); actor Chris Jackson (Bull (2016)); Bleachers perform." 54 "Sarah Paulson/John Hodgman" "Actress Sarah Paulson (The Post (2017)); humorist John Hodgman." 55 "Mark Hamill/Bobby Flay" "Actor Mark Hamill (Star Wars: The Last Jedi (2017)); chef Bobby Flay;" 56 "Matt Damon/Rahm Emanuel/Juanes" "Actor Matt Damon (\"Downsizing\"); Chicago Mayor Rahm Emanuel; Juanes perform." 57 "Tom Hanks/Katy Tur/Mac DeMarco" "Actor Tom Hanks (\"The Post\"); journalist Katy Tur; Mac DeMarco sits in with Jon Batiste and Stay Human." 58 "Nick Jonas/Dennis Rodman/Jeezy/Tory Lan... "Actor Nick Jonas (Jumanji: Welcome to the Jungle (2017)); retired basketball player Dennis Rodman; Jeezy performs with Tory Lanez." 59 "Adam Driver/John Early/Jon Batiste" "Actor Adam Driver (Star Wars: The Last Jedi (2017)); actor John Early (The Disaster Artist (2017)); Jonathan Batiste performs." 60 "Jodie Foster/Tom Hanks" "Actress Jodie Foster (Becoming Iconic (2018)); actor Tom Hanks (The Post (2017));" 61 "Anderson Cooper/Maz Jobrani/Margo Price... "Journalist Anderson Cooper (Anderson Cooper 360\u00b0 (2003)); actor Maz Jobrani (Superior Donuts (2017)); Margo Price performs." 62 "America Ferrera/David Harbour/Julien Ba... "Actress America Ferrera (Superstore (2015)); actor David Harbour (Stranger Things (2016)); Julien Baker performs." 63 "50 Cent/Rachel Brosnahan/Gary Vider" "Actor 50 Cent (Power (2014)); actress Rachel Brosnahan (The Marvelous Mrs. Maisel (2017)); comedian Gary Vider performs." 64 "Neil deGrasse Tyson" "Astrophysicist Neil deGrasse Tyson." 65 "Liam Neeson/Michael Wolff/Andra Day/Com... "Actor Liam Neeson (The Commuter (2018)); author Michael Wolff (book, \"Fire and Fury\"); Andra Day and Common perform." 66 "James Franco/Lena Waithe/Anderson East" "Actor James Franco (The Disaster Artist (2017)); actress Lena Waithe (The Chi (2018)); Anderson East performs." 67 "Sarah Jessica Parker/Pete Holmes/Jack B... "Actress Sarah Jessica Parker (Divorce (2016)); comic Pete Holmes (Crashing (2017)); Jack Black performs." 68 "Molly Shannon, Thomas Lennon, Owen Smit... "Actress Molly Shannon; actor Thomas Lennon; stand-up comedy performance by Owen Smith" 69 "Laurie Metcalf" "Actress Laurie Metcalf (Lady Bird (2017) and Roseanne (1988))." 70 "John Lithgow, Chuck Schumer, Black Eyed... "Actor John Lithgow (The Crown (2016)); Sen. Chuck Schumer (D-N.Y.); The Black Eyed Peas perform." 71 "Jon Bon Jovi, Daniel Kaluuya, Ben Sincl... "Musician Jon Bon Jovi; actor Daniel Kaluuya (Black Panther (2018)); actor Ben Sinclair (High Maintenance (2016));" 72 "Ricky Gervais, Matt Czuchry, Jon Bon Jo... "Actor Ricky Gervais (\"Blazing Samurai\"); actor Matt Czuchry (\"The Resident\"); Jon Bon Jovi performs." 73 "Sharon Stone, Rob Riggle, Fall Out Boy" "Actor Sharon Stone (\"Mosaic\"); actor Rob Riggle (\"12 Strong\"); Fall Out Boy performs." 74 "J.K. Simmons/Rob Riggle" "Actor J.K. Simmons (Counterpart (2017)); actor Rob Riggle (12 Strong (2018));" 75 "James Corden/Ann Curry" "TV host James Corden (The 59th Annual Grammy Awards (2017) and The Late Late Show with James Corden (2015)); journalist Ann Curry." 76 "John Dickerson/Eugene Levy/Midland" "Journalist John Dickerson (CBS This Morning (1992)); actor Eugene Levy (Schitt's Creek (2015)); Midland perform." 77 "Willem Dafoe/RuPaul Charles/Roy Wood Jr... "Willem Dafoe; RuPaul Charles (RuPaul's Drag Race All Stars (2012)); Roy Wood Jr. (This Is Not Happening (2015))." 78 "Gwyneth Paltrow/Ben McKenzie/Thirty Sec... "Actress Gwyneth Paltrow (Avengers: Infinity War (2018)); actor Ben McKenzie (Gotham (2014)); Thirty Seconds to Mars perform." 79 "Kyle MacLachlan/Deon Cole/Miley Cyrus/J... "Kyle MacLachlan (Twin Peaks (2017)); Deon Cole (Black-ish (2014)); Miley Cyrus salutes Elton John. Also: Julia Michaels performs." 80 "Julie Chen/Joel Kinnaman/Talib Kweli fe... "TV hostess Julie Chen (Big Brother (2000) and The Talk (2010)); actor Joel Kinnaman (Altered Carbon (2018)); Talib Kweli performs with BJ the Chicago Kid;" 81 "Pod Save America/Jessica Williams and P... "Podcast hosts Tommy Vietor, Jon Favreau and Jon Lovett (Pod Save America (2017)); Jessica Williams and Phoebe Robinson (2 Dope Queens (2018)); Chris Stapleton performs." 82 "Rose McGowan/Rand Paul/Jacob Williams/C... "Actress Rose McGowan (Citizen Rose (2018) and book, \"Brave\"); Sen. Rand Paul (R-Ky.); comedian Jacob Williams; Curtis Harding sits in with Jon Batiste and Stay Human." 83 "Michael Shannon/Meghan McCain/John Mell... "Actor Michael Shannon (\"The Shape of Water\"); TV hostess Meghan McCain (\"The View\"); John Mellencamp performs." 84 "Uma Thurman/Jacob Williams" "Actress Uma Thurman (The War with Grandpa (2019)); comic Jacob Williams performs." 85 "Claire Danes/Bernadette Peters/Lil Uzi ... "Actress Claire Danes (A Kid Like Jake (2018) and Homeland (2011)); Bernadette Peters (Mozart in the Jungle (2014)); Lil Uzi Vert performs." 86 "Wanda Sykes/Thomas Haden Church/June Di... "Actress Wanda Sykes (Hurricane Bianca: From Russia with Hate (2018)); actor Thomas Haden Church (Divorce (2016)); actress June Diane Raphael (Grace and Frankie (2015)); The Soul Rebels sit in with Jon Batiste and Stay Human." 87 "John Oliver/Beanie Feldstein/Wolfgang P... "Comic John Oliver (Last Week Tonight with John Oliver (2014)); actress Beanie Feldstein (The Female Brain (2017) and Lady Bird (2017)); chef Wolfgang Puck;" 88 "Joel McHale/Yara Shahidi/Joywave" "Actor Joel McHale (A Futile and Stupid Gesture (2018) and [The X-Files\"]); actress Yara Shahidi (\"Grown-ish\" and \"Black-ish\"); Joywave perform." 89 "Nathan Lane/John Oliver" "Actor Nathan Lane; comic John Oliver (Last Week Tonight with John Oliver (2014))." 90 "Kirsten Gillibrand/Chris Gethard/Portug... "Sen. Kirsten Gillibrand (D-N.Y.); comic Chris Gethard; Portugal. The Man perform." 91 "Sam Rockwell/J.J. Abrams/Bu00d8RNS" "Actor Sam Rockwell (Three Billboards Outside Ebbing, Missouri (2017)); director J.J. Abrams (Star Wars: The Rise of Skywalker (2019)); B\u00f8rns performs;" 92 "Christine Baranski/Constance Zimmer/Bon... "Actress Christine Baranski (The Good Fight (2017) and Mamma Mia! Here We Go Again (2018)); actress Constance Zimmer (UnREAL (2015)); Bon Jovi perform." 93 "Jennifer Lawrence/Patton Oswalt/MGMT" "Actress Jennifer Lawrence (Red Sparrow (2018)); actor Patton Oswalt (Happy! (2017)); MGMT perform." 94 "Kiefer Sutherland/Zoe Lister-Jones/John... "Actor Kiefer Sutherland (Designated Survivor (2016)); actress Zoe Lister-Jones (Life in Pieces (2015)); American linguist John McWhorter;" 95 "Donald Glover/Omarosa Manigault-Newman/... "Actor Donald Glover (Atlanta (2016)); reality-TV personality Omarosa Manigault-Newman (Celebrity Big Brother (2018)); Ibeyi perform." 96 "Jeff Daniels/Krysten Ritter/Noah Kahan" "Actor Jeff Daniels (The Looming Tower (2018)); actress Krysten Ritter (Jessica Jones (2015)); Noah Kahan performs." 97 "Steve Buscemi/Sebastian Maniscalco" "Actor Steve Buscemi (Miracle Workers (2019)); comic Sebastian Maniscalco;" 98 "David Oyelowo/Chelsea Clinton/Martha St... "Actor David Oyelowo (A Wrinkle in Time (2018) and Gringo (2018)); author Chelsea Clinton; lifestyle expert Martha Stewart;" 99 "Oprah Winfrey/Justin Hartley" "Actress Oprah Winfrey (A Wrinkle in Time (2018)); actor Justin Hartley (This Is Us (2016));" 100 "Reese Witherspoon/Adam Rippon/Ben Harpe... "Actress Reese Witherspoon (A Wrinkle in Time (2018)); Olympic figure skater Adam Rippon; Ben Harper and Charlie Musselwhite perform;" 101 "Mindy Kaling/Chris Hayes/Amberia Allen" "Actress Mindy Kaling (A Wrinkle in Time (2018)); journalist Chris Hayes; comic Amberia Allen;" 102 "Helen Mirren/David Byrne" "Helen Mirren (The Leisure Seeker (2017)); David Byrne is interviewed and performs." 103 "Tom Brady/Sean Bean/Emmy Blotnick" "Professional football player Tom Brady (Tom vs. Time (2018)); actor Sean Bean; Emmy Blotnick performs stand-up." 104 "Angela Bassett/Jimmy O. Yang/Jack Johns... "Actress Angela Bassett (Black Panther (2018), 9-1-1 (2018), Avengers: Infinity War (2018)); actor Jimmy O. Yang (Life of the Party (2018)); Jack Johnson performs;" 105 "Paul Giamatti/Sean Bean/Brandi Carlile" "Actor Paul Giamatti (\"Billions\", \"The Catcher Was a Spy\" and \"I Think We're Alone Now\"); actor Sean Bean (\"The Oath\"); Brandi Carlile performs;" 106 "Drew Barrymore/Adam DeVine/Moby" "Actress Drew Barrymore (Santa Clarita Diet (2017)); actor Adam Devine (Modern Family (2009) and When We First Met (2018)); Moby performs;" 107 "Hilary Swank/Thomas Middleditch/Rory Al... "Actress Hilary Swank (Trust (2018)); actor Thomas Middleditch (Replicas (2018)); comic Rory Albanese;" 108 "Keri Russell and Matthew Rhys/Mindy Kal... "Keri Russell and Matthew Rhys (The Americans (2013)); Mindy Kaling (\"A Wrinkle in Time\" and \"Champions\"). Also: Stephen works out with Justice Ruth Bader Ginsburg." 109 "Sean Penn/Sara Gilbert/Bishop Briggs" "Actor Sean Penn (The Professor and the Madman (2019)); actress Sara Gilbert (Roseanne (1988)); Bishop Briggs performs;" 110 "Samantha Bee/Leslie Odom Jr./Tom Segura... "Comic Samantha Bee (Full Frontal with Samantha Bee (2016)); actor Leslie Odom Jr. (The Jazz Ambassadors (2018)); comic Tom Segura;" 111 "Dana Carvey/Simon Pegg" "Dana Carvey (Too Funny to Fail: The Life & Death of The Dana Carvey Show (2017)); Simon Pegg (Ready Player One (2018))." 112 "Emily Blunt/John Heilemann & Alex Wagne... "Actress Emily Blunt (A Quiet Place (2018) and Sherlock Gnomes (2018)); journalist John Heilemann and TV hostess Alex Wagner (CBS This Morning: Saturday (2012)); Kacey Musgraves performs." 113 "Bryan Cranston/President Jimmy Carter" "Actor Bryan Cranston (Isle of Dogs (2018)); former President Jimmy Carter." 114 "Amy Schumer/Madeleine Albright/Giada De... "Actress Amy Schumer (I Feel Pretty (2018)); former Secretary of State Madeleine Albright; chef Giada De Laurentiis;" 115 "James Spader/Katie Couric/Louie Anderso... "Actor James Spader (The Blacklist (2013)); journalist Katie Couric; comic Louie Anderson (\"Baskets\" and book \"Hey Mom\");" 116 "Martin Short/Aisha Tyler" "Actor Martin Short (Love, Gilda (2018) and Steve Martin and Martin Short: An Evening You Will Forget for the Rest of Your Life (2018)); actress Aisha Tyler (Criminal Minds (2005) and Archer (2009));" 117 "Diane Sawyer/Joshua Jackson/John Prine ... "Journalist Diane Sawyer; actor Joshua Jackson (The Affair (2014)). Also: John Prine performs with Sturgill Simpson and Brandi Carlile." 118 "Aubrey Plaza/Cookie Monster/Rainbow Kit... "Aubrey Plaza (Legion (2017) and An Evening with Beverly Luff Linn (2018)); Cookie Monster (book \"The Joy of Cookies\") joins Stephen for Midnight Confessions. Also: Rainbow Kitten Surprise performs." 119 "John Dickerson/Charlamagne Tha God/Nell... "Journalist John Dickerson (CBS This Morning (1992)); TV personality Charlamagne Tha God; author Nell Scovell;" 120 "James Comey/Jason Aldean" "Former FBI director James Comey (book \"A Higher Loyalty: Truth, Lies, and Leadership\"). Also: Jason Aldean performs." 121 "Cynthia Nixon/Alan Cumming/Franz Ferdin... "Actress Cynthia Nixon discusses her campaign for Governor of New York; Alan Cumming (Instinct (2018)). Also: Franz Ferdinand performs with James Chance." 122 "Antonio Banderas/Senator Kamala Harris/... "Antonio Banderas (Genius: Picasso: Chapter One (2018)); Senator Kamala Harris (D-Calif.). Also: Snow Patrol performs." 123 "James Marsden/Coyote Peterson" "Actor James Marsden (Westworld (2016)); wildlife expert Coyote Peterson;" 124 "Jeffrey Wright/Ali Wentworth/Cheech & C... "Jeffrey Wright (Westworld (2016)); Alexandra Wentworth (book \"Go Ask Ali\"); Cheech Marin and Tommy Chong comment on drug legalization. Also: Brothers Osborne perform." 125 "Hank Azaria/Ronan Farrow/Grace VanderWa... "Actor Hank Azaria (Brockmire (2017)); author Ronan Farrow; Grace VanderWaal performs;" 126 "Lucy Liu/Henry Winkler/Run the Jewels" "Actress Lucy Liu (Future World (2018)); actor Henry Winkler (Barry (2018)); Run the Jewels perform;" 127 "Rachel Weisz/Ann Dowd" "Actress Rachel Weisz (Disobedience (2017)); actress Ann Dowd (The Handmaid's Tale (2017))." 128 "Mandy Patinkin/H. Jon Benjamin" "Mandy Patinkin (Homeland (2011) and Life Itself (2018)); H. Jon Benjamin (Archer (2009))." 129 "David Duchovny/Margaret Brennan/Robert ... "Actor David Duchovny (The X-Files (1993)); journalist Margaret Brennan (Face the Nation (1954)); actor Robert Smigel (The Week Of (2018));" 130 "Helen Hunt/Kevin Smith/Paramore" "Actress Helen Hunt (Candy Jar (2018)); filmmaker Kevin Smith (Kevin Smith: Silent But Deadly (2018)); Paramore perform;" 132 "Charlize Theron/Ron Howard/J.J. Abrams" "Charlize Theron (Tully (2018)); director Ron Howard (Solo: A Star Wars Story (2018)). Also: Producer J.J. Abrams (\"The Play That Goes Wrong\") joins Stephen for a crosstown adventure." 133 "Chris O'Donnell, Jack White" "Actor Chris O'Donnell (NCIS: Los Angeles (2009)); Jack White performs;" 134 "Jim Parsons, Alexis Ohanian, Lake Stree... "Jim Parsons, from the CBS comedy \"The Big Bang Theory\"; Co-Founder of Reddit Alexis Ohanian; musical performance by Lake Street Dive." 135 "Michael B. Jordan, Matt Walsh, Heather ... "Actor Michael B. Jordan; actor Matt Walsh; stand-up comedy performance by Heather Pasternak." 136 "Gayle King, Anna Wintour" "Gayle King, co-anchor of \"CBS This Morning\"; Vogue Editor-in-Chief Anna Winter." 137 "Annette Bening, Wyatt Cenac, Leon Bridg... "Actress Annette Bening; comic Wyatt Cenac; musical performance by Leon Bridges." 138 "Mayim Bialik, Melissa McCarthy, Daniel ... "Actress Mayim Bialik, from the CBS comedy THE BIG BANG THEORY; chef Daniel Boulud; special appearance by actress Melissa McCarthy; Run the Jewels celebrate Stephen Colbert's birthday." 139 "Anthony Anderson, Glenda Jackson, Micha... "Actor Anthony Anderson; Actress Glenda Jackson; Author Michael" 140 "Jamie Foxx, Nathaniel Rateliff & the Ni... "Actor Jamie Foxx; musical performance by Nathaniel Rateliff & The Night Sweats." 141 "Chadwick Boseman, Erik Bergstrom" "Actor Chadwick Boseman; stand-up comedy performance by Erik Bergstrom" 142 "Jake Tapper, Liam Payne featuring J. Ba... "Journalist Jake Tapper; musical performance by Liam Payne featuring J. Balvin." 143 "Benedict Cumberbatch, Mary Gallagher" "Actor Benedict Cumberbatch; stand-up comedy performance by Mary Gallagher" 144 "Zachary Quinto, Vanessa Bayer, Dean Baq... "Actor Zachary Quinto; actress Vanessa Bayer; Executive Editor of \"The New York Times,\" Dean Baquet." 145 "Andrew Garfield, David Cross, Jon Stewa... "Actor Andrew Garfield; actor\/comic David Cross; special appearance by Jon Stewart; musical performance by The Kills." 146 "Jason Bateman, Stephen King, Jim James" "Actor Jason Bateman; author Stephen King; musical performance by Jim James." 147 "Anne Hathaway, David Sedaris, Ahmed Bha... "Actress Anne Hathaway; author David Sedaris; stand-up comedy performance by Ahmed Bharoocha." 148 "Ethan Hawke, Toni Collette, Jeff Arcuri... "Actor Ethan Hawke; actress Toni Collette; stand-up comedy performance by Jeff Arcuri." 149 "Bill Clinton, James Patterson, Tig Nota... "President Bill Clinton & Author James Patterson; comic Tig Notary." 150 "Mandy Moore, Sara Bareilles, Josh Groba... "Actress Mandy Moore; Hosts of the 72nd Annual Tony Awards, singers Sara Bareilles & Josh Groan; musical performance by Meghan Trainor." 151 "Nick Offerman, Niecy Nash, Lykke Li" "Actor Nick Offerman; actress Niecy Nash; musical performance by Lykke Li." 152 "Penelope Cruz, David Koechner, Interpol... "Actress Penelope Cruz; actor David Kouchner; musical performance by Interpol." 153 "Chris Matthews/Alicia Silverstone/Eels" "TV host Chris Matthews (\"Hardball with Chris Matthews\"); actress Alicia Silverstone (\"American Woman\"); Eels perform;" 154 "Ed Helms/Michael K. Williams/Tom Papa" "Actor Ed Helms (Tag (2018)); actor Michael Kenneth Williams (SuperFly (2018)); comic Tom Papa performs;" 155 "Anthony Scaramucci and Michael Avenatti... "Former White House communications director Anthony Scaramucci and attorney Michael Avenatti. Also: Chromeo performs with D.R.A.M." 156 "Natalie Portman/Marc Maron/Alt-J/Pusha ... "Actress Natalie Portman (Eating Animals (2017)); actor Marc Maron (GLOW (2017)); Alt-J and Pusha T perform;" 157 "Thandie Newton/Betty Gilpin" "Actress Thandie Newton (\"Westworld\"); actress Betty Gilpin (\"GLOW\");" 158 "Benicio Del Toro/Alison Brie/Robin Thed... "Actor Benicio Del Toro (Sicario: Day of the Soldado (2018)); actress Alison Brie (GLOW (2017)); actress Robin Thede (The Rundown with Robin Thede (2017))." 159 "Josh Brolin/Ruth Negga/Walk The Moon" "Actor Josh Brolin (Sicario: Day of the Soldado (2018)); actress Ruth Negga (Preacher (2016)); Walk the Moon perform." 160 "Trevor Noah/Liza Koshy/Two Feet" "Comedian and television host Trevor Noah (The Daily Show (1996)); actress Liza Koshy (Liza on Demand (2018)); Two Feet performs;" 161 "Don Lemon/Mike Colter/Death Cab for Cut... "TV host Don Lemon (CNN Tonight (2014)); actor Mike Colter (Luke Cage (2016)); Death Cab for Cutie perform." 162 "Seth Rogen/Danny Jolles" "Actor Seth Rogen (Like Father (2018)); stand-up comedian Danny Jolles (Crazy Ex-Girlfriend (2015))." 163 "Jessica Chastain/Romesh Ranganathan/Sco... "Actress Jessica Chastain (Woman Walks Ahead (2017) and It: Chapter Two (2019)); comedian Romesh Ranganathan; comedian Scott Rogowsky." 164 "Hugh Grant/Margaret Hoover/Sean Donnell... "Actor Hugh Grant (A Very English Scandal (2018)); political commentator Margaret Hoover (Firing Line with Margaret Hoover (2018)); actress Laura Benanti. Also: Sean Donnelly performs stand-up." 165 "Paul Rudd/Ken Jeong/Florence + the Mach... "Actor Paul Rudd (Ant-Man and the Wasp (2018)); actor Ken Jeong (Crazy Rich Asians (2018)); musical performance by Florence and the Machine." 166 "Michael Moore/Eric Andre & Derrick Beck... "Director Michael Moore; writers and comedians Eric Andre and Derrick Beckles; politician Alexandria Ocasio-Cortez. Also: A special appearance by Jon Stewart." 167 "Gordon Ramsay/Andrew Rannells/Junun: Sh... "Chef Gordon Ramsay; actor Andrew Rannells (\"A Simple Favor\"). Also: Shye Ben-Tzur, Jonny Greenwood and The Rajasthan Express perform as Junun." 168 "Will Arnett/Neve Campbell/Marcus Samuel... "Actor Will Arnett (The Gong Show (2017)); actress Neve Campbell (Skyscraper (2018)); chef Marcus Samuelsson;" 169 "Dwayne Johnson/Alessia Cara" "Actor Dwayne Johnson (Skyscraper (2018)); Alessia Cara performs;" 170 "Lawrence O'Donnell/Liv Tyler/Young the ... "TV host Lawrence O'Donnell (The Last Word with Lawrence O'Donnell (2010)); actress Liv Tyler (Harlots (2017)); Young the Giant perform;" 171 "Carey Mulligan/Kate the Chemist" "Actress Carey Mulligan (Collateral (2018)). Also: Experiments with Kate the Chemist (Kate Biberdorf)." 172 "Armie Hammer/Colleen Ballinger/Paula Po... "Actor Armie Hammer (\"Sorry to Bother Your\"); actress Colleen Ballinger (Haters Back Off! (2016)); comic Paula Poundstone performs;" 173 "Chrissy Metz/Lewis Black/Luke Combs" "Actress Chrissy Metz (\"This Is Us\"); comic Lewis Black; Luke Combs performs;" 174 "Anderson Cooper & Andy Cohen/Dominic Co... "TV personalities Anderson Cooper (Anderson Cooper 360\u00b0 (2003)) and Andy Cohen (Watch What Happens: Live (2009)); actor Dominic Cooper (Mamma Mia! Here We Go Again (2018)); Beck performs;" 175 "Denzel Washington/Joe Kennedy III/Carme... "Actor Denzel Washington (The Equalizer 2 (2018)); Rep. Joe Kennedy III (D-Mass); comic Carmen Lagala performs;" 176 "Janelle Monu00e1e" "Janelle Mon\u00e1e (Welcome to Marwen (2018)) talks and performs." 177 "Eric Holder/John Cleese/Arctic Monkeys" "Former Attorney General Eric Holder; actor John Cleese; Arctic Monkeys perform;" 178 "Tatiana Maslany/Michael McFaul/Brian Hu... "Actress Tatiana Maslany; Michael McFaul, former ambassador to Russia; actor Brian Huskey;" 179 "John Dickerson/Michaela Watkins" "Journalist John Dickerson (CBS This Morning (1992)); actress Michaela Watkins (Casual (2015));" 180 "Jake Tapper/Michael Pena/Dua Lipa" "Journalist Jake Tapper; actor Michael Pe\u00f1a (Ant-Man and the Wasp (2018)); Dua Lipa performs;" 181 "Laura Linney/Sasheer Zamata/Lin-Manuel ... "Laura Linney (Ozark (2017)); Sasheer Zamata performs stand-up. Also: A special performance from Stephen and Lin-Manuel Miranda." 182 "Judd Apatow/Jace Norman/OneRepublic" "Filmmaker Judd Apatow; actor Jace Norman (Henry Danger (2014)); OneRepublic perform;" 183 "Paul Giamatti/Ronda Rousey/Paul Mecurio... "Actor Paul Giamatti (Billions (2016)); professional wrestler Ronda Rousey (\"Mile 22\"); comic Paul Mecurio performs;" 184 "Ewan McGregor/Adam Pally/Katie Hannigan... "Actor Ewan McGregor (\"Christopher Robin\"); actor Adam Pally (\"Dog Days\"); comic Katie Hannigan performs;" 185 "Chloe Grace Moretz/Bobcat Goldthwait/Ka... "Actress Chloe Grace Moretz (The Miseducation of Cameron Post (2018)); actor Bobcat Goldthwait (Bobcat Goldthwait's Misfits & Monsters (2018)); comic Katie Hannigan performs;" 186 "Rob Reiner/Ruth Bader Ginsburg" "Actor-director Rob Reiner (Shock and Awe (2017)). Also: Stephen looks back at his workout date with Ruth Bader Ginsburg." 187 "Chris Hayes/Rob Corddry/Regina Spektor" "Political commentator Chris Hayes (All In with Chris Hayes (2013)); actor Rob Corddry (Dog Days (2018) and Ballers (2015)); Regina Spektor performs;" 188 "Joe Manganiello/Cory Booker/Michael Pal... "Actor Joe Manganiello (Drunk Parents (2019)); Sen. Cory Booker (D-N.J.); comic Michael Palascak performs;" 189 "Jim Acosta/Nina Dobrev" "Journalist Jim Acosta; actress Nina Dobrev (Dog Days (2018));" 190 "Issa Rae/Darren Criss/Ronnie Chieng" "Actress Issa Rae (Insecure (2016)); actor Darren Criss (American Crime Story (2016)); comic Ronnie Chieng performs;" 191 "Nicki Minaj/Guy Pearce/Mac Miller" "Rapper Nicki Minaj; actor Guy Pearce (The Innocents (2018)); Mac Miller performs;" 192 "Mark Wahlberg/Bernie Sanders" "Actor Mark Wahlberg (\"Mile 22\"); Sen. Bernie Sanders (I-Vt.);" 193 "Jessica Biel/W. Kamau Bell/Elle King" "Actress Jessica Biel (\"Shock and Awe\" and \"The Sinner\"); comic W. Kamau Bell (\"Sorry to Bother You\"); Elle King performs;" 194 "Pod Save America/Constance Wu" "Jon Favreau, Jon Lovett and Tommy Vietor (Pod Save America (2017)); Constance Wu (Crazy Rich Asians (2018)). Also: A tribute to Aretha Franklin." 1 "John Krasinski, Yvonne Orji" "Stephen welcomes actor John Krasinski and actress Yvonne Orji." 2 "Rob Lowe, John Kerry, Kathleen Madigan" "Stephen welcomes actor Rob Lowe, former Secretary of State John Kerry, and comic Kathleen Madigan." 3 "Emma Thompson, Troye Sivan" "Stephen welcomes actress Emma Thompson and talks with musical guest Troye Sivan." 4 "Sharon Osbourne, Kathleen Madigan, Jay ... "Stephen welcomes TV host Sharon Osbourne, comic Kathleen Madigan, with musical guest Jay Rock." 5 "Bob Woodward, The Knocks, Foster the Pe... "Stephen welcomes journalist Bob Woodward with musical guests The Knocks and Foster the People." 6 "Neil deGrasse Tyson, Michael Rapaport" "Stephen welcomes astrophysicist Neil deGrasse Tyson and actor Michael Rapaport." 7 "Keira Knightley, Beto O'Rourke, Martha ... "Stephen welcomes actress Keira Knightley, Rep. Beto O\u2019Rourke, and television personality Martha Stewart." 8 "John Heilemann, Alex Wagner, Judy Greer... "Stephen welcomes journalist John Heilemann, journalist Alex Wagner, actress Judy Greer, with musical guest First Aid Kit." 9 "Anna Kendrick, Anne-Marie" "Stephen welcomes actress Anna Kendrick, with musical guest Anne-Marie." 10 "u201cAdmit It, You Forgot This Happened... "A celebration of the show\u2019s third anniversary. Stephen showcases a variety of clips from the show's past year." 11 "Jane Fonda, Willie Nelson" "Stephen welcomes actress Jane Fonda and talks with musical guest Willie Nelson." 12 "Tiffany Haddish, Iain Armitage" "Stephen welcomes actress Tiffany Haddish and actor Iain Armitage." 13 "Hillary Rodham Clinton, Nik Dodani" "Stephen welcomes former secretary of state Hillary Rodham Clinton and comic Nik Dodani." 14 "Emma Stone, Flight of the Conchords" "Stephen welcomes actress Emma Stone with musical guest Flight of the Conchords." 15 "America Ferrera, Nas" "Stephen welcomes actress America Ferrera with musical guest Nas." 16 "Candice Bergen, Jacinda Ardern, Jon Bat... "Stephen welcomes actress Candice Bergen, Jacinda Ardern, prime minister of New Zealand, with musical guest Jon Batiste." 17 "Jeff Bridges, Cedric the Entertainer, M... "Stephen welcomes actor Jeff Bridges, actor Cedric the Entertainer, and author Mark Leibovich." 18 "Kristen Bell, Mark Leibovich, Nik Dodan... "Stephen welcomes actress Kristen Bell, author Mark Leibovich, actor Nik Dodani, and actor Jeff Bridges." 19 "Jake Tapper, Eric Idle, Lauv, Julia Mic... "Stephen welcomes TV host Jake Tapper, actor Eric Idle, with musical guests Lauv and Julia Michaels." 20 "Eva Longoria, Damon Wayans Jr., Steve K... "Stephen welcomes actress Eva Longoria, actor Damon Wayans Jr., and journalist Steve Kornacki." 21 "Nick Kroll, Jodie Whittaker, Cat Power" "Stephen welcomes actor Nick Kroll, actress Jodie Whittaker, with musical guest Cat Power." 22 "Lady Gaga, Caitlin Peluffo" "Stephen welcomes singer Lady Gaga and comic Caitlin Peluffo." 23 "Ellie Kemper, Sam Elliott" "Stephen welcomes actress Ellie Kemper and actor Sam Elliott." 24 "Melissa McCarthy, Phoebe Robinson" "Stephen welcomes actress Melissa McCarthy and actress Phoebe Robinson." 25 "Lin-Manuel Miranda, Brooke Baldwin, Lau... "Stephen welcomes actor Lin-Manuel Miranda, journalist Brooke Baldwin, and actress Laura Benanti." 26 "Peter Dinklage, Busy Philipps, Noname" "Stephen welcomes actor Peter Dinklage, actress Busy Philipps, with musical guest Noname." 27 "Joe Scarborough, Mika Brzezinski, Laura... "Stephen welcomes TV hosts Joe Scarborough with musical guests Mika Brzezinski, actress Laura Benanti, and The Revivalists." 28 "Robin Wright, Caitlin Peluffo, Hillary ... "Stephen welcomes actress Robin Wright, comic Caitlin Peluffo, former Secretary of State Hillary Rodham Clinton, and actress Melissa McCarthy." 29 "Sarah Silverman, Scott Bakula, Transvio... "Stephen welcomes comic Sarah Silverman, actor Scott Bakula, with musical guest Transviolet." 30 "Jon Favreau, Jon Lovett, Tommy Vietor, ... "Stephen welcomes podcast hosts Jon Favreau, Jon Lovett and Tommy Vietor, and TV personality Charlamagne Tha God." 31 "Gerard Butler, Rowan Atkinson, Ina Gart... "Stephen welcomes actor Gerard Butler, actor Rowan Atkinson, and author Ina Garten." 32 "Gayle King, Andrea Bocelli, Matteo Boce... "Stephen welcomes TV host Gayle King with musical guests Andrea and Matteo Bocelli." 33 "Phil McGraw, Kayli Carter, Janelle Monu... "Stephen welcomes Dr. Phil McGraw, actress Kayli Carter, with musical guest Janelle Mon\u00e1e." 34 "Kerry Washington, Taylor Mac" "Stephen welcomes actress Kerry Washington and talks with musical guest Taylor Mac." 35 "Sarah Jessica Parker, Nancy Pelosi, Chr... "Stephen welcomes actress Sarah Jessica Parker, Rep. Nancy Pelosi (D- Calif.), with musical guests Christine and the Queens." 36 "Mike Myers, Christiane Amanpour" "Stephen welcomes actor Mike Myers and journalist Christiane Amanpour." 37 "Chris Wallace, Cole Sprouse, Tony Benne... "Stephen welcomes TV anchor Chris Wallace, actor Cole Sprouse, with musical guest Tony Bennett." 38 "Billy Eichner, Itzhak Perlman" "Stephen welcomes actor Billy Eichner and talks with musical guest Itzhak Perlman." 39 "Jude Law, Amy Klobuchar" "Stephen welcomes actor Jude Law and Senator Amy Klobuchar." 40 "John Heilemann, Alex Wagner, Hasan Minh... "Stephen welcomes journalist John Heilemann, journalist Alex Wagner, and comic Hasan Minhaj. (A live broadcast for election night.)" 41 "Chris Pine, Major Garrett" "Stephen welcomes actor Chris Pine, Major Garrett, and CBS News chief White House correspondent." 42 "Billy Crystal, Kirsten Gillibrand, Big ... "Stephen welcomes actor Billy Crystal, Senator Kirsten Gillibrand, with musical guest Big Red Machine." 43 "Alexander Skarsgu00e5rd, Triumph The In... "Stephen welcomes actor Alexander Skarsg\u00e5rd, Triumph The Insult Comic Dog, with musical guest Big Red Machine." 44 "Hugh Jackman, Jeff Tweedy, Six-String S... "Stephen welcomes actor Hugh Jackman, Jeff Tweedy talks and performs, and Six-String Soldiers sit in with Jon Batiste & Stay Human." 45 "Rachel Weisz, Jason Mantzoukas, Demetri... "Stephen welcomes actress Rachel Weisz, actor Jason Mantzoukas, comic Demetri Martin, and actor Dolph Lundgren." 46 "Ricky Gervais, Bianna Golodryga, Flynn ... "Stephen welcomes comic Ricky Gervais, TV personality Bianna Golodryga, and chef Flynn McGarry." 47 "Ben Stiller, Jemele Hill, Jorja Smith" "Stephen welcomes actor Ben Stiller, sports journalist Jemele Hill, with musical guest Jorja Smith." 48 "Timothu00e9e Chalamet, Sonia Sotomayor,... "Stephen welcomes actor Timoth\u00e9e Chalamet, Supreme Court Justice Sonia Sotomayor, and comic Graham Kay." 49 "Millie Bobby Brown, Anthony Salvanto, J... "Stephen welcomes actress Millie Bobby Brown, CBS News anchor Anthony Salvanto, with musical guest Josh Groban." 50 "Michael Douglas, Ben Sasse" "Stephen welcomes actor Michael Douglas and Senator Ben Sasse." 51 "Connie Britton, George R.R. Martin, Jos... "Stephen welcomes actress Connie Britton, author George R.R. Martin, and chef Jos\u00e9 Andr\u00e9s." 52 "Cartoon Thanks-travaganza" "Stephen and Jon\u2019s Cartoon Thanks-travaganza." 53 "Jon Stewart, Neil deGrasse Tyson, Jake ... "Stephen welcomes comedian Jon Stewart, astrophysicist Neil deGrasse Tyson, journalist Jake Tapper, actress Kerry Washington, and comic Charlamagne Tha God." 54 "Eric McCormack, David Alan Grier, Sara ... "Stephen welcomes actor Eric McCormack, actor David Alan Grier, with musical guest Sara Bareilles." 55 "Garth Brooks, Tim Meadows" "Stephen welcomes singer Garth Brooks and actor Tim Meadows." 56 "Michelle Obama, Common" "Stephen welcomes former first lady Michelle Obama with musical guest Common." 57 "Catherine Zeta-Jones, Lucas Hedges, Nat... "Stephen welcomes actress Catherine Zeta-Jones, actor Lucas Hedges, with musical guest Nathaniel Rateliff & the Night Sweats." 58 "Julia Roberts, Patrick Wilson" "Stephen welcomes actress Julia Roberts and actor Patrick Wilson." 59 "Jeff Daniels, Emily Mortimer" "Stephen welcomes actor Jeff Daniels and actress Emily Mortimer." 60 "Bernie Sanders, Chris Gethard" "Stephen welcomes Senator Bernie Sanders (I-Vt.) and comic Chris Gethard." 61 "Kathy Griffin, Emma Willmann" "Stephen welcomes comic Kathy Griffin and comic Emma Willmann." 62 "Bryan Cranston, Doris Kearns Goodwin" "Stephen welcomes actor Bryan Cranston and historian Doris Kearns Goodwin." 63 "Whoopi Goldberg, Adam Pally, Jungle" "Stephen welcomes TV host Whoopi Goldberg, actor Adam Pally, with musical guest Jungle." 64 "Leslie Mann, Brandon Micheal Hall, Lil'... "Stephen welcomes actress Leslie Mann, actor Brandon Micheal Hall, with musical guest Lil\u2019 Wayne." 65 "Diane Kruger, Rep. Joaquin Castro, Juli... "Stephen welcomes actress Diane Kruger, Rep. Joaquin Castro, former Secretary of Housing and Urban Development Juli\u00e1n Castro, and writer Ira Madison III." 66 "Tony Shalhoub, Joe Wong, Bryan Cranston... "Stephen welcomes actor Tony Shalhoub, comic Joe Wong, actor Bryan Cranston, actress Laura Linney, actress Rachel Dratch, TV host John Oliver, and actor Nick Kroll." 67 "Sandra Bullock, Barry Jenkins" "Stephen welcomes actress Sandra Bullock and director Barry Jenkins." 68 "Emily Blunt, Adam Schiff, St. Paul & Th... "Stephen welcomes actress Emily Blunt, Rep. Adam Schiff, with musical guest St. Paul & The Broken Bones." 69 "Steve Carell, KiKi Layne" "Stephen welcomes actor Steve Carell and actress KiKi Layne." 70 "John C. Reilly, Sen. Jeff Flake" "Stephen welcomes actor John C. Reilly and Senator Jeff Flake." 71 "Laura Benanti, Jon Stewart, Jon Batiste... "Stephen welcomes actress Laura Benanti, comic Jon Stewart, with musical guest Jon Batiste & Stay Human." 72 "Ethan Hawke, Jon Glaser, Taylor Bennett... "Stephen welcomes actor Ethan Hawke, actor Jon Glaser, with musical guest Taylor Bennett." 73 "Keegan-Michael Key, Josh Hutcherson" "Stephen welcomes actor Keegan-Michael Key and actor Josh Hutcherson." 74 "Kevin Hart, Nicole Byer" "Stephen welcomes actor Kevin Hart and comic Nicole Byer." 75 "Kamala Harris, Bradley Whitford, Gary C... "Stephen welcomes Senator Kamala Harris, actor Bradley Whitford, with musical guest Gary Clark Jr.." 76 "Curtis u201c50 Centu201d Jackson, Jamie... "Stephen welcomes actor Curtis \u201c50 Cent\u201d Jackson and chef Jamie Oliver." 77 "James McAvoy, Sonequa Martin-Green, Kan... "Stephen welcomes actor James McAvoy, actress Sonequa Martin-Green, with musical guest Kane Brown." 78 "Kirsten Gillibrand, M. Night Shyamalan" "Stephen welcomes Senator Kirsten Gillibrand and filmmaker M. Night Shyamalan." 79 "Jake Gyllenhaal, Pete Holmes" "Stephen welcomes actor Jake Gyllenhaal, comic Pete Holmes." 80 "Sarah Paulson, Killer Mike, Future" "Stephen welcomes actress Sarah Paulson, rapper Killer Mike, with musical guest Future." 81 "William H. Macy, Rebecca Traister" "Stephen welcomes actor William H. Macy and author Rebecca Traister." 82 "Alexandria Ocasio-Cortez, Method Man" "Stephen welcomes Rep. Alexandria Ocasio-Cortez and rapper Method Man." 83 "Drew Barrymore, Mo Rocca, Maggie Rogers... "Stephen welcomes actress Drew Barrymore, TV personality Mo Rocca, with musical guest Maggie Rogers." 84 "Matthew McConaughey, Better Oblivion Co... "Stephen welcomes actor Matthew McConaughey with musical guest Better Oblivion Community Center." 85 "Michael Moore, Ken Marino, Dermot Kenne... "Stephen welcomes filmmaker Michael Moore, actor Ken Marino, with musical guest Dermot Kennedy." 86 "John Goodman, Samantha Ruddy" "Stephen welcomes actor John Goodman and comic Samantha Ruddy." 87 "Cliff Sims, Paul Simon" "Stephen welcomes the former special assistant to President Donald Trump, Cliff Sims, with musical guest Paul Simon." 88 "Chris Christie, Yvette Nicole Brown" "Stephen welcomes former Gov. Chris Christie and actress Yvette Nicole Brown." 89 "John Heilemann, Mark McKinnon, Alex Wag... "Stephen welcomes journalist John Heilemann, political consultant Mark McKinnon, journalist Alex Wagner, and actor Max Greenfield." 90 "Ellen Page, Radhika Jones, Django Gold" "Stephen welcomes actress Ellen Page, Radhika Jones, Editor-in-Chief of \u201cVanity Fair\u201d, and comic Django Gold." 91 "Super Bowl Edition, with Conan O'Brien,... "Stephen welcomes TV host Conan O\u2019Brien, James Taylor performs, and surprise guests." 92 "Taraji P. Henson, Matt Walsh, Marie Kon... "Stephen welcomes actress Taraji P. Henson, actor Matt Walsh, and TV personality Marie Kondo." 93 "Live broadcast following the State of t... "Stephen welcomes journalists Norah O\u2019Donnell, John Dickerson, Gayle King and Bianna Golodryga, and filmmaker Spike Lee." 94 "Steve Buscemi, Bret Baier, Sasha Sloan" "Stephen welcomes actor Steve Buscemi, TV personality Bret Baier, with musical guest Sasha Sloan." 95 "Chris Pratt, Meghan McCain, Beirut" "Stephen welcomes actor Chris Pratt, TV personality Meghan McCain, with musical guest Beirut." 96 "Glenn Close, Byron Bowers" "Stephen welcomes actress Glenn Close and comic Byron Bowers." 97 "John Oliver, BLACKPINK" "Stephen welcomes TV host John Oliver with musical guest BLACKPINK." 98 "Regina King, Bill Gates, Melinda Gates,... "Stephen welcomes actress Regina King, philanthropists Bill and Melinda Gates, and comic Jena Friedman." 99 "Trevor Noah, Natasha Lyonne" "Stephen welcomes TV host Trevor Noah and actress Natasha Lyonne." 100 "Bradley Cooper, Pete Buttigieg" "Stephen welcomes actor Bradley Cooper and Democratic presidential hopeful Pete Buttigieg." 101 "Jeff Goldblum, Jacques Torres, The Marc... "Stephen welcomes actor Jeff Goldblum, chef Jacques Torres, with musical guest The Marcus King Band." 102 "Jake Tapper, Amy Sedaris, The Claypool ... "Stephen welcomes journalist Jake Tapper, actress Amy Sedaris, with musical guest The Claypool Lennon Delirium." 103 "Andrew McCabe, Dan Levy, Sigrid" "Stephen welcomes former Deputy Director of the FBI Andrew McCabe, actor Dan Levy, with musical guest Sigrid." 104 "Reba McEntire, Margaret Brennan" "Stephen welcomes singer-songwriter Reba McEntire and TV host Margaret Brennan." 105 "Annette Bening, Ana Navarro, Ben Platt" "Stephen welcomes actress Annette Bening, political commentator Ana Navarro, with musical guest Ben Platt." 106 "Don Cheadle, Colin Quinn" "Stephen welcomes actor Don Cheadle and comic Colin Quinn." 107 "Julianne Moore, Thomas Lennon, Bebe Rex... "Stephen welcomes actress Julianne Moore, actor Thomas Lennon, with musical guest Bebe Rexha." 108 "Kit Harington, Amber Tamblyn, Hozier" "Stephen welcomes actor Kit Harington, actress Amber Tamblyn, with musical guest Hozier." 109 "Willie Geist, Phoebe Waller-Bridge, Dwa... "Stephen welcomes TV personality Willie Geist, actress Phoebe Waller-Bridge, and comic Dwayne Perkins." 110 "Gayle King, Pamela Adlon, Mumford & Son... "Stephen welcomes journalist Gayle King, actress Pamela Adlon, with musical guest Mumford & Sons." 111 "Cory Booker, Matt Ingebretson, Jake Wei... "Stephen welcomes Senator Cory Booker and actors Matt Ingebretson and Jake Weisman." 112 "Damian Lewis, Tulsi Gabbard, Ellie Goul... "Stephen welcomes actor Damian Lewis, Rep. Tulsi Gabbard, with musical guest Ellie Goulding." 113 "John Turturro, Andrew Rannells, Robyn" "Stephen welcomes actor John Turturro, actor Andrew Rannells, with musical guest Robyn." 114 "Patricia Arquette, Ian McShane, Strand ... "Stephen welcomes actress Patricia Arquette, actor Ian McShane, Strand of Oaks, with musical guests Jason Isbell and Amanda Shires." 115 "Christine Baranski, Adam Kinzinger, Apa... "Stephen welcomes actress Christine Baranski, Rep. Adam Kinzinger, and comic Aparna Nancherla." 116 "Laura Benanti, Donnie Wahlberg, Heidi S... "Stephen welcomes actress Laura Benanti, actor Donnie Wahlberg, playwright Heidi Schreck, and actress Christine Baranski." 117 "Lupita Nyong'o, Vicky Ward, Spike Jonze... "Stephen welcomes actress Lupita Nyong\u2019o, author Vicky Ward, with musical guests Spike Jonze directs aance by Karen O and Danger Mouse." 118 "Chris Hayes, Nico Parker" "Stephen welcomes journalist Chris Hayes and actress Nico Parker." 119 "Paul Giamatti, Doug Jones, Aparna Nanch... "Stephen welcomes actor Paul Giamatti, Senator Doug Jones, comic Aparna Nancherla, and Rep. Alexandria Ocasio-Cortez." 120 "Elizabeth Warren, Tony Hale" "Stephen welcomes Senator Elizabeth Warren and actor Tony Hale." 121 "Keri Russell, Martha Stewart" "Stephen welcomes actress Keri Russell and lifestyle expert Martha Stewart." 122 "Charles Barkley, Tig Notaro" "Stephen welcomes sports analyst Charles Barkley and actress Tig Notaro." 123 "Nathan Lane, Antoni Porowski, Bobby Ber... "Stephen welcomes actor Nathan Lane, TV personalities Antoni Porowski, Bobby Berk, Jonathan Van Ness, and Karamo Brown and Tan France." 124 "Emilia Clarke, Henry Winkler, H.E.R." "Stephen welcomes actress Emilia Clarke, actor Henry Winkler, with musical guest H.E.R.." 125 "John Lithgow, Stacey Abrams, Kevin Garr... "Stephen welcomes actor John Lithgow, politician Stacey Abrams, with musical guest Kevin Garrett." 126 "Sandra Oh, Zachary Levi, Nina Nesbitt" "Stephen welcomes actress Sandra Oh, actor Zachary Levi, with musical guest Nina Nesbitt." 127 "Hank Azaria, Henry Louis Gates Jr, Emil... "Stephen welcomes actor Hank Azaria, literary critic Henry Louis Gates Jr, actress Emilia Clarke, and actor Jeff Goldblum." 128 "Zach Galifianakis, Eric Swalwell, Ellie... "Stephen welcomes actor Zach Galifianakis, Rep. Eric Swalwell, with musical guest Ellie Goulding." 129 "Michelle Williams, Emily Bazelon, Oscar... "Stephen welcomes actress Michelle Williams, journalist Emily Bazelon, and a special appearance by Oscar the Grouch." 130 "Anderson Cooper, Ruth Wilson, Ilhan Oma... "Stephen welcomes journalist Anderson Cooper, actress Ruth Wilson, and Rep. Ilhan Omar." 131 "Molly Shannon, Gary Cole, Paul Simon, T... "Stephen welcomes actress Molly Shannon, actor Gary Cole, Paul Simon performs, and TV host Trevor Noah." 132 "Laurie Metcalf, Ramy Youssef, Cage the ... "Stephen welcomes actress Laurie Metcalf, actor Ramy Youssef, with musical guest Cage the Elephant." 133 "Anna Palmer, Jake Sherman, The Lumineer... "Stephen welcomes journalists Anna Palmer with musical guests Jake Sherman & The Lumineers, special appearances by the cast of \u201cAvengers: Endgame\u201d, and actor Peter Grosz." 134 "Samantha Bee, Retta, Neal Katyal, Cage ... "Stephen welcomes TV host Samantha Bee, actress Retta, lawyer Neal Katyal\u2019s analysis of the Mueller Report, with musical guest Cage the Elephant." 135 "Robert De Niro, Beth Behrs" "Stephen welcomes actor Robert De Niro and actress Beth Behrs." 136 "Seth Rogen, Ronda Rousey, Jessica Yelli... "Stephen welcomes actor Seth Rogen, professional wrestler Ronda Rousey, and author Jessica Yellin." 137 "Christina Applegate, Van Jones, Bear Gr... "Stephen welcomes actress Christina Applegate, author Van Jones, and adventurer Bear Grylls." 138 "Mariska Hargitay, Thomas Middleditch, H... "Stephen welcomes actress Mariska Hargitay, actor Thomas Middleditch, with musical guest Hootie & the Blowfish." 139 "Chris Cuomo, Nicholas Hoult, Lily Colli... "Stephen welcomes journalist Chris Cuomo, actor Nicholas Hoult, actress Lily Collins, with musical guest James Taylor." 140 "Craig Ferguson, Ronda Rousey" "Stephen welcomes actor Craig Ferguson and professional wrestler Ronda Rousey." 141 "Common, Rachel Dratch, Maren Morris" 142 "Anne Hathaway, Ari Melber" 143 "Bryan Cranston, RuPaul Charles" 144 "Julia Louis-Dreyfus, Anna Chlumsky, Ton... 145 "Keanu Reeves, Santino Fontana" 155 "Wanda Sykes, Vanessa Bayer" 156 "Emma Thompson, Adam Scott" 157 "James Corden, Zou00eb Kravitz, Lewis Ca... 158 "Mindy Kaling, Seth Green" 159 "Elisabeth Moss, Matt Bomer" 160 "Samuel L. Jackson, Ash Carter" 161 "Tim McGraw, Jon Meacham, Tessa Thompson... 162 "Beto O'Rourke, Billy Porter" 163 "Kevin Bacon, Mark Ronson, Lykke Li" 164 "Aubrey Plaza, Dan Abrams" 165 "Dax Shepard, Preet Bharara, Lukas Nelso... 166 "Chris Matthews, Jessie Buckley" 167 "Ice Cube, Tig Notaro" 168 "Russell Crowe, Lori Lightfoot, The Raco... 169 "Naomi Watts, The Raconteurs" 170 "Tom Holland, Andrew Yang" 171 "Zendaya, Julian Edelman, Jenny Lewis" 172 "Alexandria Ocasio-Cortez, Incubus" 173 "Chris Christie, Carly Zakin, Danielle W... 174 "Ricky Gervais, X Ambassadors" 175 "Awkwafina, Donny Deutsch, The Mountain ... 176 "Sofu00eda Vergara, David Cross, Tove Lo... 177 "Norah O'Donnell, Topher Grace" 178 "John Oliver, Joe Namath" 179 "Jake Gyllenhaal, Marianne Williamson, D... 180 "Juliu00e1n Castro, Tony Hale, Nilu00fcf... 181 "Chris Wallace, Jamie Bell" 182 "Jeff Goldblum, Aisha Tyler" 183 "John Leguizamo, Ricky Gervais, Candice ... 184 "Idris Elba, Maude Apatow, Perry Farrell... 185 "Jeff Daniels, Katy Tur, Jacob Soboroff" 186 "Rahm Emanuel, Michael Ian Black" 187 "Meek Mill" 188 "Brian Cox,Hannah Gadsby, and Shane Torr... 189 "Amanda Seyfried, Jacob Tremblay, Brady ... 190 "Tiffany Haddish, Jared Harris, The Smas... 191 "Ron Burgundy" 192 "Cate Blanchett, Marc Maron" 193 "Jada Pinkett Smith, Rep. Ayanna Pressle... 194 "Curtis u201c50 Centu201d Jackson, Jilli... 195 "Kirsten Dunst, Adam Devine, Lee Pace" 91 "Tyra Banks/Rahm Emanuel/Hailee Steinfel... "Model Tyra Banks (\"Modelland\"); former Chicago Mayor Rahm Emanuel (book, \"The Nation City\"); Hailee Steinfeld performs;" 94 "John Turturro/Charlamagne Tha God/Kaleo... "Actor John Turturro (\"The Jesus Rolls\"); radio personality Charlamagne Tha God; Kaleo perform;" 95 "Tyra Banks/Coyote Peterson" "TV personality (theme park, \"Model Land\"); TV host Coyote Peterson (\"Coyote Peterson: Brave the Wild\");" 97 "Anthony Mackie/Susan Glasser" "Actor Anthony Mackie (\"The Woman in the Window\"); journalist Susan Glasser;" 117 "Trevor Noah/Jose Andres/Willie, Lukas, ... "Stephen Colbert at home; TV host Trevor Noah (\"The Daily Show\"); chef Jose Andres; Willie, Lukas, and Micah Nelson perform;" Trailer: The Late Show with Stephen Colbert	cc/2021-04/en_middle_0036.json.gz/line991
__label__wiki	0.500444	0.500444	Last edited by Brashicage 2 edition of Single cell protein found in the catalog. Jean A. Larson January 1984 - September 1990 by Jean A. Larson Published 1990 by National Agricultural Library in Beltsville, Md . Single cell proteins -- Bibliography. Statement Jean A. Larson. Series Quick bibliography series -- QB 91-38., Quick bibliography series -- 91-38. Contributions National Agricultural Library (U.S.) Pagination 12, 5, 5 p. ; Production of single cell protein (SCP) from natural gas in a one liter bubble column reactor and optimization of the process parameters were investigated. The medium specifi-cations, nitrogen sources, initial inoculum volume, and inlet ratio of gas to air were considered as process parameters to be optimized. The optimum condition for highest File Size: KB. Quick & easy science fun Collecting country & western Americana Within these walls; Royal Fusiliers in the Great War BPA proposed fiscal year 1994 budget Reasoning, Necessity, and Logic Computerized tomography Studies in wound infections Public Funding of Higher Education Rebellious Civil Society When we belonged to Spain Stuart Little I Can Read Library Ye Gods Introduction to Organic & Biochemistry Annála Connacht = Single cell protein by Jean A. Larson Download PDF EPUB FB2 The use of single-cell protein (SCP) derived from unicellular organisms such as bacteria, yeasts, algae, and fungi is a promising answer to the problem of developing low-cost protein malnutrition. The importance of such an innovation, were it to come about, is obvious. In order to discuss and evaluate the prospective role of SCP in world food supply, a number of authorities gathered at M.I.T. Although single cell protein has high nutritive value due to higher protein, vitamin, essential amino acids and lipid content, there is a doubt to be replaced to the conventional protein sources. The situation, accompanied with rapid population growth demands exploration of new & un-conventional protein sources to fortify human foods. Saccharomyces cerevisiae is very promising and cost effective source of single cell protein due to its bigger size, easy harvesting, lower amount of nucleic acids and good blend of essential amino : $ The single-cell protein (SCP) concept is applied to the massive growth of microorganisms for human or animal consumption. Single-cell protein is a generic term for crude or refined protein whose origin is bacteria, yeasts, molds, or algae, microorganisms that usually contain above. Single-Cell Protein: Safety for Animal and Human Feeding covers the proceedings of the Protein-Calorie Advisory Group of the United Nations System Symposium “Investigations On Single-Cell Protein,” held at the Istituto di Ricerche Farmacologiche 'Mario Negri' Milan, Italy, on March 31 – April 1, This text is divided into three parts. The first part discusses taxonomy and. Shortly after my return, Professor Richard Mateles, who at that time was head of the Department, suggested that I purchase a good and comprehensive book on single cell protein (SCP) in order to expand my general knowledge in the subject I had started then to work on; that was microbial utilization of one-carbon (C) compounds. l Naturally, I Brand: Springer-Verlag Berlin Heidelberg. The other is associated with NSP8, a 22kD protein which is unique to coronaviruses and is capable of de novo initiation of RNA synthesis with low fidelity from single strand RNA templates. Thus, NSP8 has been proposed to operate as a primase, that is it makes oligonucleotide primers that can then be used by NSP12, the major RNA-dependent RNA. Single-cell proteins are the dried cells of microorganism, which are used as protein supplement in human foods or animal feeds. Microorganisms like algae, fungi, yeast and bacteria, utilize inexpensive feedstock and wastes as sources of carbon and energy for growth to produce biomass, protein concentrate or amino acids. Since protein accounts for the quantitatively important part of the. Additional Physical Format: Online version: Goldberg, Israel, Single cell protein. Berlin ; New York: Springer-Verlag, © (OCoLC) Define single-cell protein. single-cell protein synonyms, single-cell protein pronunciation, single-cell protein translation, English dictionary definition of single-cell protein. single-cell; single-cell protein; single-celled; single-chamber; single-channel; single-cross. It also explores the benefits and potential drawbacks of single-cell protein, with an emphasis on the economic advantages of such processes. Given its multidisciplinary scope, the book represents a valuable resource for academics and industry practitioners interested in the production of single-cell protein from lignocellulosic : Springer Singapore. The term ‘single cell protein’ was coined in at a meeting held at the Massachusetts Institute of Technology (MIT) to replace the less aesthetic ‘microbial protein’ and ‘petroprotein. Challenges in single-cell protein analysis. The biggest challenges to measuring proteins in single cells (assuming they have been successfully isolated from a tissue, microbial community or culture) are vanishingly small amount of protein in a single cell and the enormous complexity of the by: This volume highlights recent developments in flow cytometry, affinity assays, imaging, mass spectrometry, microfluidics and other technologies that enable analysis of proteins at the single cell level. The book also includes chapters covering a suite of biochemical and biophysical methods capable of making an entire gamut of proteomic. 4. WHAT ARE SINGLE CELL PROTEINS?• SCP are dried cells of micro organisms which can be used as dietary protein supplement.• They are used as animal feed & can be used for human feed as protein supplement.• Also called ‘Novel Food’ & ‘Minifood’. HISTORY• Part of our diet since ancient times.• Earlier known as ‘Microbial. Shortly after my return, Professor Richard Mateles, who at that time was head of the Department, suggested that I purchase a good and comprehensive book on single cell protein (SCP) in order to expand my general knowledge in the subject I had started then to work on; that was microbial utilization of one-carbon (C) compounds. l Naturally, I. Single-cell studies of the genome and transcriptome are all the rage as sequencing technologies are reaching maturity. No two cells are exactly Cited by: protein. For this reason, innew sources mainly bacteria, yeast, fungi and algae were used to produce protein biomass named Single Cell Protein (SCP). The term SCP was coined in by Carol L. Wilson. Single cell protein is dried cells of microorganism, which are used as protein ISSN: Volume 4 Number 9 () pp. As single-cell proteomics emerges, perhaps labs can avoid the need to infer protein levels from mRNA abundances. Nowadays, labs can generate massive Cited by: Single Cell Protein Market Drivers and Trends Increasing number of malnutrition cases across the globe is driving the market for single cell protein over the forecast period. Data from UNICEF states that globally half of the deaths in children’s under age five are due to malnutrition or under nutrition/5(36). "Based on papers presented at an international conference on single-cell protein held at the Massachusetts Institute of Technology, OctoberThe conference was sponsored by the Department of Nutrition and Food Science and the Sloan School of Management.". Title: Single Cell Protein: Production and Process Author: A.T. Nasseri, S. Rasoul-Amini, M.H. Morowvat and Y. Ghasemi Subject: American Journal of Food Technology. Single-cell protein definition is - protein that consists of processed microorganisms (such as yeasts or bacteria) grown in culture and that is used as a source of food especially for livestock. INTRODUCTION The term “Single Cell Protein” refers to the total protein extracted from the pure cultures of microorganisms (e.g. yeast, algae, filamentous fungi, bacteria) and can be used as a protein-rich food supplements by humans and animals. Many types of animal feeds contain single cell proteins. Also called ‘Novel Food. single cell protein: CELLS of MICROORGANISMS grown primarily for use as a source of protein for animal or human food. Single cell protein may be used directly as a food, for example PRUTEEN or QUORN, or as a food supplement, for example yeast extract. Microorganisms have certain properties that make them particularly suitable for use as a. The single-cell protein produced by ICI from methanol and ammonia using M. methylotrophus was referred to as ICI pruteen. This SCP was exclusively used for animal feeding. ICI invested a huge amount (around £40 million) in and installed a continuous culture system for SCP production. This was the world’s largest continuous airlift. Workshop on Single-Cell Protein: Summary Report, Jakarta, Indonesia, FebruaryNational Academies, - Single cell proteins - 68 pages. 0 Reviews. Preview this book. This single cell shows the process of the central dogma of biology, which are all steps researchers are interested to quantify (DNA, RNA, and Protein). In the field of cellular biology, single-cell analysis is the study of genomics, transcriptomics, proteomics and metabolomics at the single cell level. Due to the heterogeneity seen in both. Define single-cell proteins. single-cell proteins synonyms, single-cell proteins pronunciation, single-cell proteins translation, English dictionary definition of single-cell proteins. single-cell protein; single-cell proteins; single-celled; single-chamber; single-channel; single-cross; single-cut file. In this paper, a mathematical model of cheese whey fermentation for single-cell protein production with impulsive state feedback control is proposed. Which will give a conclusion theoretically to the researchers in the field of single-cell protein production. The cell is the basic unit of biology and protein expression drives cellular function. Tracking protein expression in single cells enables the study of cellular pathways and behavior but requires methodologies sensitive enough to detect low numbers of protein molecules with a wide dynamic range to distinguish unique cells and quantify population distributions. Comparison of protein at RNA levels for thousands of genes at single-cell resolution. The low dimensional projections of single-cell protein and RNA measurements result in similar clusters albeit the clusters based on RNA measurements are more spread out, suggesting more biological and technical variability in the RNA ers: Microfluidic flow cytometry for single-cell protein analysis microfluidics and other technologies that enable analysis of proteins at the single cell level. The book also includes chapters covering a suite of biochemical and biophysical methods capable of making an entire gamut of proteomic measurements, including analysis of protein. Single cell proteins are considered as alternative source of food nutrients. Spirulina is an important single cell protein which is rich in proteins, vitamins and minerals. To view other chapter. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these limitations, we developed Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS), and validated its ability to identify distinct human cancer cell types based on their proteomes. in a single cell hence, a suite of biochemical biophysical methods have been developed as dis-cussed in the following sections. Single-cell protein analysis by ﬂow cytometry The mostestablishedanduser-friendlymethodforsingle cell derives protein analysis is ﬂow cytometry. Its effectiveness from thefact that while absolute amounts of proteins. single cell protein (SCP) yeasts, other fungi or algae are cultivated in large quantities as human or animal protein supplement in animal feed or in human nutrition. Source: PAC,Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford. Four sections cover protein structure, enzymes, special proteins, and membrane transport. There are brief problem sets following chapters, short bios of notable protein scientists, and references and an index provided in the appendices of the textbook. The size of the book is manageable for students. White Dog Labs offers a sustainable solution by producing Single Cell Protein (SCP), with similar protein and amino acid content as fishmeal. The solution combines MixoFerm high yield, with its FlexFeedstock capability (e.g., by-products from ethanol plants), and a low-cost plant that is co-located with existing infrastructure such as dry-grind. This book focuses on bioconversion of lignocellulosic residues into single-cell protein, which offers an alternative to conventional proteins (such as soybean meal, egg protein or meat protein in animal feed) that is not affected by the climate. Suggested Citation:"Front Matter."National Research Council. Workshop on Single-Cell Protein: Summary Report, Jakarta, Indonesia, FebruaryWashington.single-cell protein (SCP) Protein produced by microorganisms, such as bacteria, yeasts, and unicellular algae, that is extracted for use as a component of human and animal foods. Source for information on single-cell protein: A Dictionary of Biology dictionary.03/04/ Single Cell Protein (NRM) 2 Single cell protein • The term single cell protein (SCP) refers to dead, dry cells of micro-organisms such as yeast, bacteria, fungi and algae which grow on different carbon sources. The name "single cell protein" was used . truetax.online - Single cell protein book © 2020	cc/2021-04/en_middle_0036.json.gz/line994
__label__wiki	0.553673	0.553673	Last edited by Faebei 6 edition of The colonel"s tale found in the catalog. The colonel"s tale S. H. Baker Published 2009 by Zumaya Enigma in Austin, TX . Police chiefs -- Louisiana -- Fiction, Cajuns -- Fiction, Authors -- Fiction, Nineteen twenties -- Fiction, Lake Charles (La.) -- Fiction Statement by S.H. Baker. Series A Dassas Cormier mystery LC Classifications PS3619.T693 C65 2009 Pagination p. cm. Jan 01, · Buy a cheap copy of The Colonels Daughter book by Merline Lovelace. She wasnt afraid to fight Beneath the polish of an Eastern finishing school lies a soldiers daughter who can ride, shoot and deal cards with the best. Which Free shipping over $Author: Merline Lovelace. Part historical mystery, part biography, part cultural studies, The Convict and the Colonel is a fascinating story of a society in transition and the role of the prophetic figure in historical memory. "Price quotes a phrase from colleague Sidney Mintz about the kind of anthropology that is 'at the fault line between the large and the little.'. text-book of psychiatry Peradventure Cocker spaniels. The Big Green Book of Italian Verbs From Specimen of a commentary on Shakespeare (1794) [on Macbeth]. Mortality among Negroes in cities measure of responsibility Pastoral Amendment Measure fora on the protection of women and children-- vital to development Growing & using sage Aboriginal use of shell on Cape York Peninsula El Aliso Fun in Europe Murder at La Marimba National parks for Britain. The colonel"s tale by S. H. Baker Download PDF EPUB FB2 The Colonel's Tale (Dassas Cormier Mystery) [S. Baker] on truetax.online FREE shipping on qualifying offers. A much-anticipated Thanksgiving with his family is disrupted as Dassas Cormier must travel from Marshall's Bayou to Lake Charles to help his sister and her companion4/5(2). May 14, · The Paperback of the The Colonel's Tale by S. Baker at Barnes & Noble. FREE Shipping on $35 or more. B&N Outlet Membership Educators Gift Cards Stores & Events Help Auto Suggestions are available once you type at least 3 letters. Smokey Annicelli Book 1Tony Annicelli (aka Smokey) retired from the NYPD after he took four Brand: Zumaya Publications. A tale of two colonels, Alexander Vindman and Oliver North: Frank “Gus” Biggio. Posted Feb 12, Things worked out well for him, though, as he landed book deals, launched a radio show. Feb 21, · It's good to see them again and I'm enjoying the stories for their simplicity and novelty. Many of them have been many times since in different ways and with newer actors. This doesn't detract from the original version at all. It's like reading a favorite book again and again or listening to a favorite tune for the umpteenth time. Aug 20, · The Two Colonels is a story DLC for Metro Exodus that is part of the Expansion Pass. It takes place in the Novosibirsk Metro before the arrival of the Aurora Crew and follows the story of Colonel Khlebnikov. The story provides more details about the fall of Novosibirsk. The Two Colonels was. The Colonel, the short form of the title for Alanna Nash's book The Colonel: The Extraordinary Story of Colonel Tom Parker and Elvis Presley The Colonels, a novel by W.E.B. Griffin The Colonels, the regime of Polish colonels during the period "The Colonel's Lady" is, without a doubt, the best book I've read all year. Laura Frantz is an exceptional author. The plot gripped me from the beginning, and the author lost no time revealing the book's theme of love, forgiveness, and war-time intrigue/5. The Colonel's Mistake is good thriller mainly based in Azerbaijan, an asian country formally controlled by the Soviets and now influenced by Iran. The synopsis tells the reader that an CIA operative Daria has been arrested for murder and detained. Her former CIA mentor, (now retired), Mark is /5. Aug 01, · Laura Frantz is a relatively new author to me—The Colonel’s Lady is the first book I have read by her—but I must say she quickly has become one of my favorites. Laura does a wonderful job of weaving mystery, intrigue, and romance together in this Revolutionary War historical, making it nearly impossible to put down/5. The Books: A Phenominon In Popular Literary Culture. This page is dedicated to "The Books" themselves. We have made all the "Little Colonel" books available to the public on this site below, including photographs of the covers, title pages, illustrations, etc. Colonel (/ ˈ k ɜːr n əl / "kernel"; abbreviated Col., Col or COL) is a senior military officer rank below the brigadier and general officer ranks. However, in some small military forces, such as those of Monaco or the Vatican, colonel is the highest truetax.online is also used in some police forces and paramilitary organizations. Historically, in the seventeenth, eighteenth and nineteenth. The Colonel and Little Missie: Buffalo Bill, Annie Oakley, and the Beginnings of Superstardom in America by McMurtry, Larry and a great selection of related books, art and collectibles available now at. Serena Joy in The Handmaid's Tale. Serena Joy She Should Be Named Bittera Sad. Serena Joy is neither serene nor joyful. Then again, Serena Joy isn't her real name. In a novel full of characters referred to by pseudonyms, Serena Joy seems to stand out because she's. The Colonel's Tale is S.H. Baker's third mystery to feature Dassas Cormier, who is Chief of Police in his small hometown of Marshall's Bayou. Nov 05, · Liksom's tale is a brilliantly drawn metaphor, and just as it took tremendous hardship and effort for so many people to wake up from their simplistic, codependent love affair with fascism, so the narrator faces the painful and torturous challenge of struggling to break free of her relationship with the Colonel and to rebuild a new life for 3/4(5). Jun 20, · A Tale of Two Colonels. By Amy Davidson Sorki n. June 20, In the last week, two American colonels have been subject to disciplinary action for Author: Amy Davidson Sorkin. truetax.online - Buy The Colonel's Daughters; Or, Life Is But a Dream. a Tale. book online at best prices in India on truetax.online Read The Colonel's Daughters; Or, Life Is But a Dream. a Tale. book reviews & author details and more at truetax.online Free delivery on qualified truetax.online: E Clere. Love reigns supreme for our three brave colonels at the start of this epic tale. Colonels Buford, Fitzwilliam, and Brandon are enjoying their courtships and their early married lives with three beloved Jane Austen heroines. The couples lead tranquil lives- until Napoleon escapes from exile. Colonels In Blue Indiana Kentucky And Tennessee A Civil War Biographical Dictionary. Welcome,you are looking at books for reading, the Colonels In Blue Indiana Kentucky And Tennessee A Civil War Biographical Dictionary, you will able to read or download in Pdf or ePub books and notice some of author may have lock the live reading for some of country. Jun 08, · Colonel Cain shares his memories of the th Division during WWII. It starts slowly, with an inventory of facts and details. You might think it's a tale about something neighborly. The details are described without adornment or emotional affect. That flatness adds to the feeling of suspense. You're more likely to try to read into the description. Watch Tales of the Unexpected - Season 9, Episode 2 - The Colonel's Lady: Eve, the wife of Colonel George Peregrine, writes a book of love poems which is a huge success. Eve is soon in demand ev /10(6). The Little Colonel. I enjoyed reading The Little Colonel by Annie Fellows Johnston. The book is well written and has good old-fashioned values. The Little Colonel, with her winning ways, brings about a reconciliation between her mother and her grandfather. It's a great book.5/5(1). With the Colonel’s Help is just one of Leenie Brown’s numerous Pride and Prejudice inspired stories. If you like well-written, sweet romance where family ties are strong, understanding runs deep, and love rises above any obstacle, then you will love this story about. The Colonel's Lady -eBook () by Laura Frantz. Laura Frantz credits her grandmother as being the catalyst for her fascination with Kentucky history/5(52). What is a boxed book set. A boxed set is a complete boxed book series. It is appropriate for a collector or a new reader. Boxed sets can be passed down through generations as heirlooms. Collections such as the Little House books transcend generational differences and provide ways for people of all ages to connect to each other. Aug 20, · The first story DLC for Metro Exodus has been released today. It is called The Two Colonels. I show you my walkthrough of it and hope you enjoy. Colonel Heller is a Nazi colonel and main antagonist in Bedknobs and Broomsticks. An officer in the Wehrmacht Heer (Nazi Germany's regular armed forces), Heller doesn't appear until close to the end of the film. He and his men, including two sergeants, are dropped off by a submarine off the. The book received very little critical attention. Ironically, the author's hope, inscribed in the book's dedication, "to bring the forces of enlightenment to bear upon the vexed problems which harass the South," proved a message—like that of his noble protagonist—largely ignored. Greene’s book is widely regarded as a classic, prophetic literary tale that examines the start of American engagement in Vietnam. The acclaimed English novelist and journalist, who covered the French war in Vietnam from to ’54, set the book in Saigon. Jan 08, · Bombastic George Peregrine is amazed when his meek wife Eve writes a best-selling romantic novel. Despite his own infidelity he is certain that, from the graphic descriptions of sex in the book, Eve is also having an affair but when he quizzes her on the subject her reply is even more hurtful/10(2). Yossarian is placed in ridiculous, absurd, desperate, and tragic circumstances—he sees friends die and disappear, his squadron get bombed by its own mess officer, and colonels and generals volunteer their men for the most perilous battle in order to enhance their own reputations. Catch is a law defined in various ways throughout the truetax.online by: Liksom's tale is a brilliantly drawn metaphor, and just as it took tremendous hardship and effort for so many people to wake up from their simplistic, codependent love affair with fascism, so the narrator faces the painful and torturous challenge of struggling to break free of her relationship with the Colonel and to rebuild a new life for. Summaries. It looks like we don't have any Plot Summaries for this title yet. Be the first to contribute. Just click the "Edit page" button at the bottom of the page or learn more in. Nov 08, · You Can’t Be Knighted in the U.S., But You Can Be Named a Sagamore of the Wabash Or a Kentucky Colonel. Or a Nebraska Admiral. Or a Commodore of the State of Rhode Island and Providence truetax.online: Eric Grundhauser. But the narrator’s lack of interest in introspection ultimately makes her recitations of events almost boring, especially for readers who don’t have the historical knowledge to follow the shifts back and forth in time. This slim novel works best when it reads like a dark fairy. May 17, · So, what happens at the end of Catch?Throughout Heller's novel, the narration jumps around in time, but as the book nears its ending, the story Author: Sadie Trombetta. The Little Colonel's Good Times Book. In response to many queries by children, the author created a "Good Times Book," such as Betty kept, which was published in this beautiful format uniform with the Little Colonel series and also in white kid. The Lost City of Z: A Tale of Deadly Obsession in the Amazon User Review - Staff - Book Verdict. To fully follow his story, Mitchell Zuckoff (Frozen in Time) helped fund the expedition to search for the Duck and traveled with the team to Greenland.4/5(15). An excerpt of the book was hailed by Tibor Fisher in the Guardian as “right up there with Catch and Michael Herr’s Dispatches,” and the book won Russia’s inaugural Debut Prize, which recognizes authors who write “despite, not because of, their life circumstances.” Beyond. Jan 09, · Slow-cooking expert Stephanie O'Dea shares the story behind her KFC-inspired chicken: It was an attempt to recreate the Colonel's secret recipe so .Oct 26, · With both bold and intricate strokes, master storyteller Laura Frantz has painted a breathtakingly beautiful tale in The Colonel's Lady. With equal amounts of history and romance, this literary gem will immerse you into another time and place and keep you turning the pages until the satisfying conclusion.The Colonel's Ideas by Guy de Maupassant. The Colonel's Ideas is a stirring reverie during wartime."“It was not a Trochu, but a Sainte-Genevieve, who was needed in Paris; and I remember a little anecdote of the war which proves that we are capable of everything in presence of a woman."/ truetax.online - The colonels tale book © 2020	cc/2021-04/en_middle_0036.json.gz/line995
__label__wiki	0.659919	0.659919	Film Review: The Longest Ride April 10, 2015 — Leave a comment “Love requires sacrifice…always”. It’s been a long ride, and after riding the wave of The Notebook for over a decade, Nicholas Sparks can rest assured that the newest cinematic adaptation of one of his infamously familiar romance novels isn’t a complete dud, and that is saying a lot. Throughout the year, audience members expect to see certain films on the silver screen; Halloween brings forth a new Paranormal, or Purge; summer brings us a new Marvel action tentpole, while Valentine’s Day usually brings us another Nicholas Sparks romance. Sadly, while many would have loved to see this film on Valentine’s Day instead of the widely popular Fifty Shades of Grey, The Longest Ride was pushed for a release in April, just in time for…spring? The unfortunate fate of a Nicholas Sparks romance film is that, most of the times, they never really have to be as bad as they usually are. While The Notebook seems to be the mecca of Sparks’ novels and films with critics and audience members, his track record is usually mediocre at best, with many awful variations. With last year’s The Best of Me, the film brought a whole new low to the Sparks canon, barely making an effort to conceal a slight age difference but obvious physical maturity difference between its two young leads. Thankfully, The Longest Ride casts two vibrant and talented actors to bring their characters and most importantly, chemistry to life. While you could guess that every Sparks romance involves two parallel love stories, a dark personal secret, a past and present rendering, a World War II reference, an infamous scene in the rain, and very noticeable slices of Americana, The Longest Ride only fulfills half of the typical Sparks criteria, allowing the film itself to play on a fresher slate than half a dozen of his previously adapted films. This time around, we are introduced to the eclectic and cultured Sophia (Britt Robertson), a young and beautiful woman studying in North Carolina on a full scholarship. Chasing her dream of becoming an art curator in the Big Apple, Sophia closes herself off from her large sorority along with any distractions that could come her way, especially when she finds herself blending into the country culture of North Carolina. Forced to accompany her friend Marcia (Melissa Benoist) to a bull-riding competition full of cute cowboys, Sophia agrees to take some time away from studying, seeing that she only has two months left of school before she moves to New York for an internship she’s accepted in a prestigious gallery. While her time at the competition seems filled only with her friends, Sophia is quickly given the attention of all-around American cowboy and competitive bull rider Luke Collins (Scott Eastwood). What begins as an innocent night at the local saloon after Luke’s graceful win that places him thirty-sixth in the world, turns into a romantic date with take out food and a perfect scenic background for the two. While Luke exercises every opportunity to be a gentleman, on the ride back home to Sophia’s sorority, Luke and Sophia stumble across a car afire through a guard-rail in a ditch of a side road. While Luke pulls out an unconscious elderly man, Sophia pulls out a box filled with the man’s most prized possessions. Staying with the man overnight at the hospital, Sophia and Ira (Alan Ida) begin a special friendship blossomed from Sophia’s willingness to read Ira his letters back to home, remembering his memories of his deceased wife Ruth (Oona Chaplin). While the similarities of young Ira (Jack Huston) and Ruth’s life beg to make their way into Sophia and Luke’s relationship, the young couple begin to question the route of their lives and the acceptance of whether or not they are meant to be. With any good Sparks film, there is always an independent director trying to reinvent them self for a career in the mainstream. Luckily this time around, George Tillman Jr. was the man responsible for directing Sparks latest, and like Lasse Hallstrom, the director at the helm of Safe Haven and Dear John, as well as other very successful light-hearted fares including Chocolat, The Cider House Rules and most recently The Hundred-Foot Journey, Tillman Jr. continues Hallstrom’s tradition of executing successful romance without ever down playing its cliched niche and obvious narrative directions. Tillman Jr. does some of the best work with his actors in creating very real yet idealized characters within Sparks’ world. The Longest Ride may be the longest running Sparks adaptation but is also, next to The Notebook, the best casted. Robertson and Eastwood beg for genuine sympathy for their struggles as a new couple without ever being overbearing. Many of their relationship conflicts could easily be understood and accepted by a modern day audience, especially those of the younger demographic. With social media and apps like OKCupid, Plenty of Fish, and Lava Life trying to base relationships on compatibility, The Longest Ride glorifies the very truthful reality that sometimes relationships aren’t based on similarities. The film exposes a world that confirms sometimes opposites attract – a notion many young people need to begin to accept. Although many might complain of its duration, The Longest Ride (no pun intended) does also showcase one of the Sparks cannon’s best flashbacks since The Notebook. Jack Huston and Oona Chaplin, playing young versions of the experienced couple Ira and Ruth, bring the idea of Southern hospitality and narrative comfort back into the tired genre. Much like the career of M. Night Shayamalan, I don’t think audiences will ever get a Sparks adaptation that will be better than The Notebook, while other films like A Walk to Remember and The Longest Ride will continue to satisfy audiences, begging to never see iterations that are closer to the flat and tired Safe Haven and The Last Song side of things. While you can always be sure that whatever World War II scene Sparks depicts the film will never have a large enough budget to show a grand scope of action or production value to that scene, The Longest Ride will surely satisfy die-hard fans and casual cinema goers without much of a fuss. Expect the cliched, expect trademark romantic genre film tropes, and in this case specifically, expect your female companion to fall in love with a cowboy. Better dust off those cowboy boots that creepy uncle once bought you gents, southern chivalry will surely make a comeback once she sees this one. Night Film Reviews: 7.5 Out of 10 Stars. Is The Longest Ride one of the better Sparks adaptations? Or Worse? How’s the chemistry? Did you fall in love all over again or beg for it to be over? Let us know what you think of The Longest Ride below. This entry was posted in Reviews and tagged Alan Alda, Britt Robertson, Craig Bolotin, Film Reviews, George Tillman Jr., Jack Huston, Lolita Davidovich, Melissa Benoist, Movie Reviews, Nicholas Sparks, Night Film Reviews, Oona Chaplin, Scott Eastwood, The Longest Ride. Bookmark the permalink.	cc/2021-04/en_middle_0036.json.gz/line996
__label__wiki	0.936233	0.936233	Sunday, January 26, 4:00 pm Rainbow Cinemas, Northumberland Mall, Cobourg The Grizzlies is an inspiring true story based on a group of Inuit students in the small Arctic town of Kugluktuk. Suffering from widespread drug use, alcohol abuse, domestic violence and one of the highest teen suicide rates in the world, this northern community is periled by the legacy of colonialism. Director: Miranda de Pencier Writers: Moira Walley-Beckett, Graham Yost Stars: Jack Anawak, Fred Bailey, Seth Burke Genre: Drama Rating: 14A Language: English, Inuktitut By Stephen Farber Inspirational sports stories are nothing new, but a fresh milieu and a vivid cast of characters can revitalize any genre, and The Grizzlies — an excellent Canadian film directed by Miranda de Pencier — stands out as a stirring and compelling variation on a popular theme. The pic is based on a true story of a lacrosse team from the northernmost reaches of Canada, and most of the actors are Inuit. After a couple of festival showings where it proved to be an audience favorite, the film is seeking U.S. distribution and definitely deserves a showcase. The Grizzlies begins arrestingly, with a scene of a young Inuit man going to a remote spot and shooting himself. We then cut to the arrival of Russ Shepherd (Ben Schnetzer), a teacher sent to this outpost because his options are almost as limited as those of the young people who live in the wintry village. He finds a completely unmotivated group of students, but his own naivete leads him to believe that he can make a difference in their lives. Although the pic initially threatens to become one more tale of a white savior rescuing native people from their worst impulses, it turns out that Russ has more to learn from his students and others in his community than they do from him. He tries to motivate them by getting them interested in playing lacrosse, which he insists is more of a Canadian national sport than hockey. The resistance he faces is believable, and in the end, he comes to appreciate the obstacles facing all the town residents. They are the ones who ultimately take charge and achieve a victory on their terms rather than his. Performances help to enliven the movie. Schnetzer, an engaging actor who has had prominent roles in such films as The Book Thief and the gay British drama Pride, resists the temptation to idealize the character. Russ comes across as brash and determined, but also blind to the real challenges in the lives of the people he wants to inspire. Russ can actually be more than a little dense, but his upbeat spirit keeps us on his side. De Pencier did a superb job finding fine actors, including several native to the region, to portray the young students and townspeople. Ricky Marty-Pahtaykan, Paul Nutarariaq and Booboo Stewart all register strongly as young men who refuse to be bullied. The director and screenwriters Moira Walley-Beckett and Graham Yost also created substantial roles for actresses. Emerald MacDonald as the smartest student in the class makes a particularly strong impression, and Tantoo Cardinal (who played a major role in Dances with Wolves in 1990) is also memorable as the school principal who protests Russ’ naivete and is only gradually and believably won over to his cause. Several other characters speak their native language and cement the sense of authenticity. The director and cinematographer Jim Denault expertly convey the bleak beauty of the Arctic landscape. The filmmakers wisely chose to shoot on harsh real locations, and they add immeasurably to the movie’s portrayal of the impediments to these young men’s survival. Veterans Frank Marshall and Jake Steinfeld acted as executive producers and clearly played an important role in backing this story. It turns out to be bracingly unsentimental and transcendently moving at the same time.	cc/2021-04/en_middle_0036.json.gz/line1000
__label__wiki	0.757517	0.757517	’13 Sentinels: Aegis Rim’ review: The best time in Reviews If the baker’s dozen of playable protagonists wasn’t enough of a clue, 13 Sentinels: Aegis Rim very much hews to a “more is more” approach to storytelling. If you’re looking for challenging real-time strategy, 13 Sentinels‘ straightforward action probably won’t rock your socks off. But fans of point-and-click adventures and visual novels will find a lot to chew on here, even if the overall balance between the two main lobes of the game feels a bit lopsided. Vanillaware’s latest is a true masterclass in galaxy-brain sci-fi storytelling that will keep you up well past your bedtime. It’s the best time-travel game since Chrono Trigger, even though it’s absolutely not trying to be anything like Square Enix’s 1995 SNES classic. Instead, 13 Sentinels thumbs its nose at your expectations about familiar sci-fi tropes to take you somewhere completely unexpected. Set primarily in a fictionalized Tokyo in 1985, 13 Sentinels sees a group of high-schoolers thrown into an epic struggle for the survival of humanity that spans historical periods and space. Our teen heroes — you guessed it! — must pilot a fleet of giant robots known as Sentinels in order to stave off hordes of giant monsters known as kaiju. 13 Sentinels has three core gameplay modes — Remembrance, Destruction, and Analysis — though you’ll spend the overwhelming majority of your time in the first. Remembrance is basically “story mode,” a point-and-click style retelling of the end of the world from 13 perspectives. Analysis mode is basically your glossary of events, people, and things, which updates as you progress the story. Destruction is, appropriately enough, where the robot-fighting strategy bit comes in. Iori, Satawari, and Kisuragi enjoy a snack after school. Atlus What an intricate web we weave After the prologue, which takes about two to three hours, you can jump between these modes at any time. There’s some light gating of certain characters’ story chapters to avoid spoilers, but it’s not onerous and never makes the story feel railroaded. That allows the story to unfold as more of a web than a straight line, and it’s one of the things that makes the sprawling, strange tale of 13 Sentinels so memorable. Here’s a top-of-head rundown of just some of the sci-fi tropes on the menu here: Mentally unstable teenagers piloting giant mechs Building-sized space monsters Gun-toting androids A.I. gone wild Interstellar colonization Teleporter hijinks Nefarious corporation Mystery pills In almost any other game, this would probably feel like far, far too much. Yet it all somehow works in 13 Sentinels, because the game’s structure and user interface encourage you to retrace your steps, consistently reminding you how the stories of all these characters weave together. 13 Sentinels commits wholeheartedly to a wildly ambitious narrative that wrangles with complex arguments about the ethics of A.I., the role of nature vs. nurture in shaping life outcomes, and humanity’s impact on the planet. Any good work of sci-fi will prompt you to think more deeply about real-world science, and 13 Sentinels manages to do this consistently throughout its roughly 25- to 30-hour playtime. Just when you think you’ve got this story figured out, it zigs and zags out of your grasp in a delightful new way. It doesn’t hurt that the game’s watercolored, sun-dappled environments manage to make the imminent ruin of humanity look very, very pretty. Despite generally being a big fan of pretty much any game Atlus makes, this is my first Vanillaware game, and it’s plain to see why the studio’s garnered a reputation for distinctive aesthetics. Initially, I’d expected 13 Sentinels to have a lot in common with 5pb’s Steins;Gate or Chaos Child, given that all three follow impossibly pretty Tokyo teens stumbling on impossibly complex secrets. But 13 Sentinels has far more in common with Spike Chunsoft’s cult-classic narrative adventure 428 Shibuya Scramble or Aquaplus’s more recent duo of Utewarerumono visual novels. That’s a compliment, because that latter pair of games will stick in your craw far longer, thanks to their robust ensemble casts. You probably won’t gel with every character in 13 Sentinels, but even your benchwarmers will spend plenty of time with your faves. Like 428, Vanillaware’s approach to storytelling here is iterative, meaning you’ll repeat the same scenario with the same character, and events play out slightly differently each time until you have all the information you need to advance the chapter. Each of the 13 character arcs has its own distinct feel: one draws heavily from magical girl anime, another feels like a detective story, another’s trying to scrounge for after-school snack money. This sounds far less interesting on paper than it turns out to be in practice, and each of these re-do’s only take a couple of minutes. For example, the Elvis-coiffed hardass Nenji Ogata is tasked with finding “the key” at the train station. You’ll talk to your brown-haired classmate to get a clue, which you’ll to mention next time to a mysterious girl. You’ll board one train, fail the mission, start over and wait for that train to leave, only for another conspicuous face to appear on the platform, opening up a whole new set of conversations. Unless you’re stumped and need to consult the in-game flow chart for a hint on what to do next, 13 Sentinels doesn’t knock you over the head with “gamey” prompts. Often, talking to people in a different order, waiting for someone to leave, or overhearing a conversation can unlock new pathways within the story. There’s only one ending to the overall narrative, but the freedom to jump between gameplay modes and characters willy-nilly allows it to unfold differently for each player. Minami and BJ explore Tokisaka Shrine near Sakura High. Atlus Strategy done light Mech combat in 13 Sentinels is fun and satisfying, if not particularly deep. Mostly, it helps to keep things moving at a jangly pace when you hit a wall in a particular story chapter. In the prologue, you’ll only have a few mechs to choose from, but once you get into the main part of the game, you’ll be able to choose from all 13 characters. There are four types of mechs, with some better suited to close combat, others designed to take out kaiju at long range, and support characters who can pepper the battlefield with passive weaponry while your slower teammates are puttering around. You’ll upgrade their weaponry and equipment using meta-chips won by taking down foes. These upgrades make each of the mech types a little more versatile as you advance through the game. A brief taste of the big, bright combat in 13 Sentinels. Atlus The Destruction segment of13 Sentinels serves up 31 battles across three zones of the city. (There are some extra post-game battles for those who love a challenge.) Most of these are pretty straightforward, lasting anywhere between five and 15 minutes, making it easy to breeze through several in one go. You’ll blast through literally thousands of opponents in seconds, and that sense of scale coupled with big ol’ damage numbers can be pretty darn satisfying. While some enemies require armor-piercing or anti-air weaponry, most things can just be blasted with anyone’s biggest gun. While the enemy types change, the map design is disappointingly repetitive. The addition of variable terrain and atmospheric elements would have added some welcome complexity to the proceedings. In true Neon Genesis Evangelion fashion, your pilots can’t stay in their Sentinels for too long without risking serious brain damage. That means you’ll need to change up your roster every fight to give some squad members a break. Each successive battle you complete without restoring health post-fight will multiply the number of meta-chips you can earn, making upgrades accessible earlier. This encourages you to get experimental with your roster choices early on, but makes the back-end of the game feel a trifle too easy once you start racking up those meta-chip bonuses. Any squad of six can easily lay waste to virtually anything in their path by the time you cruise into the third set of 10 battles. With more twists than a jumbo-sized basket of curly fries, 13 Sentinels: Aegis Rim will keep you guessing all the way up until its stunning finale. Just when you think you have everything figured out, it drops another shocker. 8/10. 13 Sentinels: Aegis Rim is out now on PS4. INVERSE VIDEO GAME REVIEW ETHOS: When it comes to video games, Inverse values a few qualities that other sites may not. For instance, we care about hours over money. Many new AAA games have similar costs, which is why we value the experience of playing more than price comparisons. We don’t value grinding and fetch quests as much as games that make the most out of every level. We also care about the in-game narrative more than most. If the world of a video game is rich enough to foster sociological theories about its government and character backstories, it’s a game we won’t be able to stop thinking about, no matter its price or popularity. We won’t punch down. We won’t evaluate an indie game in the same way we will evaluate a AAA game that’s produced by a team of thousands. We review games based on what’s available in our consoles at the time. For instance, we won’t hold it against a video game if its online mode isn’t perfect at launch. And finally, we have very little tolerance for junk science. (Magic is always OK.) If Apple follows its own rules, you’ll soon be able to stream your Xbox to your iPhone China Mobile Games Market Analysis and Forecasts 2020 China Mobile Games Market Analysis and Forecasts 2020-2024 - Mobile and PC Games Revenue in China Forecast to Surpass $46.7 billion by 2024 - ResearchAndMarkets.com - Business Wire	cc/2021-04/en_middle_0036.json.gz/line1001
__label__wiki	0.867635	0.867635	BLOOD IN THE STREETS: Three More Pedestrians are Dead [UPDATED] The dangerous intersection of Coney Island Avenue and Church Avenue, where a driver hit and killed a 49-year-old woman on July 8. Photo: Zainab Iqbal. Updated \| Three more pedestrians have been killed by reckless drivers — bringing the total death count on New York City streets this bloody year to 106, or 14 percent more than this time last year. The latest bloodshed comes as 15 cyclists have also been killed this year, up from 10 in all of 2018. In the most-recent pedestrian death, police say a driver hit and killed 49-year-old Maria Del Carmen Porras-Hernandez as she was crossing Coney Island Avenue in a marked crosswalk at around 9:10 a.m. on Monday. Police say the driver, 63-year-old Claudette Crosby, was heading west on Church Avenue and tried to make a right turn onto Coney Island Avenue when she struck the victim. Crosby then hit a parked car, cops added. Porras-Hernandez was taken to Maimonides Hospital where she died. Crosby remained at the scene and was not initially charged, but was later slapped with summonses for failure to yield to a pedestrian and failure to exercise due care. The intersection of Church and Coney Island avenues is notoriously dangerous and congested — so much so that the city has made it the focal point of a campaign for safer streets and faster bus service. A HORRIFICALLY bad intersection https://t.co/dfBWMBDdzb — Harry Siegel (@harrysiegel) July 8, 2019 There have been 84 crashes resulting in 21 injuries at that intersection since June, 2016, including five cyclists and eight pedestrians. Monday’s death followed the killing of 65-year-old Cleo Fields in Manhattan. In that case, police say 71-year-old Alpha Diallo was driving the wrong way down Frederick Douglass Boulevard at around 1 p.m. on Sunday when he failed to stop at a red light and slammed into another car making a left turn from W. 128th Street onto Frederick Douglass. Diallo’s car then kept going and struck Fields as he was crossing the boulevard — the impact hurled him into the air and he landed onto a parked car. Police say Diallo then struck that car, and yet another parked car. Cops arrested Diallo and charged him with manslaughter, reckless endangerment, and reckless driving. And the third recent pedestrian fatality stems from a June 29 crash, when police say a 27-year-old driver struck 72-year-old Gualberto Delgado on 108th Street near the Long Island Expressway at about 8:30 am. Cops say the driver was heading north on 108th Street when he hit Delgado as the pedestrian was crossing the roadway mid-block. Delgado lived just half a mile away from where he was killed. Paramedics rushed him to New York Presbyterian Hospital-Queens, where he died. On July 5, the city Medical Examiner determined that Delgado died from his injuries sustained in the collision — but police did not summons or arrest the driver. Since January 2016, there have been a total of 23 crashes at that dangerous intersection, resulting in 39 injuries, including six to pedestrians and one cyclist. The latest cycle of bloodshed comes as the NYPD claims it is in the midst of a three-week ticket blitz targeting reckless drivers. In all, pedestrian deaths are up slightly over last year. According to the Department of Transportation, 54 pedestrians were killed through July 7 of this year, compared to 51 over the same period last year. That’s an increase of six percent. This story was updated on Tuesday morning to reflect the charges against the driver in the Church Avenue death. Filed Under: Aggressive Driving, Bike/Ped, Crash Data, DOT, NYPD, NYPD Crash Investigations, Pedestrian Infrastructure, Pedestrian safety, The Weekly Carnage, Transportation Alternatives, Vision Zero NYPD: Another Pedestrian is Killed on Deadly Church Avenue By Julianne Cuba \| Jul 10, 2019 It's the 110th road death so far this year, up 18 percent over the same period last year. UPDATE: Two Pedestrians Struck, One Killed, By Driver on Deadly Church Avenue Two more pedestrians were struck — one fatally — by a driver on deadly Church Avenue on Saturday, the latest death in a year with double-digit increases in road carnage. Driver + Coney Island Avenue = More Death By Gersh Kuntzman and Dave Colon \| Aug 26, 2019 Another person has been killed on deadly Coney Island Avenue in Brooklyn, as a driver ran over a man who had been lying on the sidewalk near the entrance to a parking garage at a local dialysis center, cops said. In Memoriam 2019: The Lives We Lost (And The Drivers Who Weren’t Charged) By Julianne Cuba \| Jan 6, 2020 The primary cause of death on New York City roadways remains reckless drivers. Yet more than half have not been charged. Here's our annual tribute to the dead — and our annual call for action. NINETEEN: Another Cyclist Killed, This Time on Brutal Coney Island Avenue [UPDATED] Another cyclist — the 19th of this bloody, bloody year — is dead, hit by a driver on deadly Coney Island Avenue in Brooklyn. UPDATE: NYPD Arrests Driver Who Hit and Killed a Woman in the Crosswalk By Julianne Cuba \| Jul 1, 2019 Updated: Cops cuffed the driver who struck and killed a woman in a crosswalk of a Brooklyn intersection, the NYPD said on July 8. On June 30, police offered preliminary information about the death of 33-year-old Ingrid Pineda-Cuellar, who was struck by 78-year-old Jean Victorin as she crossed Utica Avenue at 6:53 a.m. on June 27. Police […]	cc/2021-04/en_middle_0036.json.gz/line1003
__label__wiki	0.922953	0.922953	Aesthetic laser firm Syneron Candela set for $400M private equity sale Apax Partners offers 15% premium to Israeli company's shareholders but rival bids could be solicited. Syneron Candela stock (past two years) Syneron Candela, the Nasdaq-listed vendor of laser-based medical and aesthetic devices, is set to be sold to private equity giant Apax Partners, in a cash deal valued at close to $400 million. The $46 billion fund has agreed a transaction price of $11 per share for Syneron Candela, whose products include multi-wavelength picosecond laser systems for removing tattoos and “pigmented lesions”, and alexandrite lasers for hair removal. It also offers non-optical technologies including ultrasound equipment for claimed fat-reduction treatments. ‘Go shop’ period The Apax deal represents a 15 per cent premium on the firm’s average closing stock price over the first quarter of 2017, and comes shortly after Israel-based Syneron Candela said it broke even on full-year revenues of $298.1 million in 2016. While the offer remains subject to approval by Syneron Candela shareholders, the firm’s board of directors has already approved the transaction unanimously – with chairman and co-founder Shimon Eckhouse, who still owns 7.4% of the company, agreeing to vote in favor of the deal. “This acquisition is a strong recognition of Syneron Candela's leadership in the aesthetic medical device market, its leading world-class technology and unique global footprint,” Eckhouse said. “These exceptional assets are a result of the many years of hard work of our skillful and dedicated employees all over the world.” He added: “We are confident that Apax will add significant value and expertise as Syneron Candela executes on its growth strategy while delivering innovative technologies to our customers and patients. I also believe that this transaction represents a positive outcome for our shareholders.” Despite that backing from Eckhouse, the Apax agreement includes a so-called “go-shop” period through May 9, during which Syneron Candela can actively solicit, evaluate and potentially enter into alternative proposals from third parties. Steven Dyson, a partner at Apax and co-head of the fund’s healthcare division, said: “We have identified the medical aesthetics market as a highly attractive investment area given its long-term growth prospects.” Dyson reckons that Syneron Candela is well positioned to capture the opportunity, mentioning the firm’s “exceptional” R&D capabilities and cutting-edge technology. “We are looking forward to partnering with the Syneron Candela team to continue its strong growth trajectory, and to seeing the even greater benefits it can deliver for customers and patients,” he said. In Syneron Candela’s most recent investor conference call, which took place in February, CEO Amit Meridor had refused to comment on press speculation about a potential sale of the business. But he did report that the company had just gained CE Mark approval for its combined laser and radio frequency product for hair removal, with other regulatory clearances for “body shaping” applications said to be in the pipeline. Syneron Candela has also signed up celebrity endorsement for its products, with controversial Olympic swimming champion Ryan Lochte apparently using its laser hair removal techniques to help “shave” his times in the pool. However, Lochte was subsequently dropped by Syneron Candela – along with several other sponsors - in the aftermath of a mysterious incident that took place at a gas station during last year’s Rio de Janeiro Olympics. Lumentum and Coherent merger to create photonics industry giant Merger back on as Cisco and Acacia agree higher price Claims and counterclaims as Acacia looks to call off Cisco merger Aeva adds $200M to listing fund Teledyne lines up $8BN FLIR acquisition Syneron Candela Syneron picosecond source tackles blue and green tattoo inks Syneron to pay Palomar $31M in patent settlement	cc/2021-04/en_middle_0036.json.gz/line1008
__label__wiki	0.810564	0.810564	You searched for: Start Over Author Murdoch, James, 1856-1921 Remove constraint Author: Murdoch, James, 1856-1921 Work Type maps (documents) Remove constraint Work Type: maps (documents) 2. Feudal Map of Japan Between 1573-83 FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134]FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134]FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134]FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134]FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134]FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134]FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134]FROM: Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 134] Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]Murdoch, James. A History of Japan: During the Century of Early Foreign Intercourse (1542-1651). Kobe: Office of the Chronicle, 1903. [map faces p. 122]	cc/2021-04/en_middle_0036.json.gz/line1010
__label__cc	0.511613	0.488387	Trail of Footprints A History of Indigenous Maps from Viceregal Mexico University of Texas Press 2019 There is far more to a map than meets the eye. Such is the case in historian Alex Hidalgo’s Trail of Footprints: A History of Indigenous Maps from Viceregal Mexico (University of Texas Press, 2019), which focuses on the complex lives of dozens of Oaxacan maps created by Indigenous mapmakers. Tracing the legal, social, cultural, and political history of these maps, Hidalgo sheds new light on the purpose, production, and preservation of maps as well as the lives of Indigenous peoples and Spaniards alike involved in their production. The result is a vivid re-orientation of Oaxacan history that speaks to the historical power of collaboration, adaptation, and cartography. Trail of Footprints provides a deep dive into the production and use of maps, focusing specifically on the roles of patrons, painters, and notaries as well as the complex material dimension of mapmaking. Hidalgo lends equal attention to both the broader historical context of mapmaking and the smallest details of each cartographic creation, emphasizing how maps both recorded and created spatial relationships. In tracing the long lives of these maps, Hidalgo demonstrates, among other important interventions, the potency of Indigenous skills, ideas, and ways of knowing in creating and charting Oaxacan history. Annabel LaBrecque is a PhD student in the Department of History at UC Berkeley. You can find her on Twitter @labrcq. Annabel LaBrecque Also Hosted By Annabel LaBrecque We Do Not Want the Gates Closed Between Us Justin Gage Picturing Indians Liza Black Unworthy Republic Claudio Saunt Reproduction on the Reservation Brianna Theobald	cc/2021-04/en_middle_0036.json.gz/line1011
__label__wiki	0.861259	0.861259	The U.S. Supreme Court Photo Illustration: Jonathan Hurtarte/Bloomberg Law Take Two—Or Three: High Court December Calendar Full of Sequels By Kimberly Strawbridge Robinson Nov. 30, 2020, 9:50 AM Nearly every case on December calendar a follow-up from previous terms Some even include the same lineup of attorneys taking the lectern From the 2020 census, to human rights, to robocalls, the Supreme Court will confront familiar issues addressed in previous cases during the December sitting that starts Monday. The entire 2020 term is full of repeat cases that tackle issues—and in one instance even the same case—that were addressed in previous terms. But “December is really the apex when it comes to the theme of déjà vu,” said Pacific Legal Foundation attorney Anastasia P. Boden, who titled her preview of the 2020 term, “Looking Ahead: Déjà Vu at the Supreme Court.” There are several reasons that sequels might make their way to the high court, said Arnold & Porter’s John Elwood. One explanation is that the Roberts Court is generally minimalist, Elwood said. If the justices “decide the minimum to dispose of a particular case, they sometimes need to revisit the issue down the road to decide different applications,” Elwood said. The best example of that this sitting is Henry Schein Inc. v. Archer and White Sales Inc., an arbitration case first argued in 2018 that returns Dec. 8. The same attorneys, Paul Weiss’s Kannon Shanmugam and Alexander Dubose Jefferson’s Daniel Geyser, will argue again. Shanmugam and Geyser will face off for the fifth time in the case’s second time at the high court. “It’s somewhat rare that a single case will give rise to multiple certworthy issues, but it does happen—especially when the Court decides a case narrowly, and it later returns presenting the broader issue,” Geyser said. The first time around, the court sided with business trying to keep matters out of federal courts. In his first Supreme Court opinion, Justice Brett Kavanaugh specifically said that the court could address new arguments against arbitration “in the first instance.” On remand, the New Orleans-based U.S. Court of Appeals for the Fifth Circuit again rejected the dental supplies wholesaler Henry Schein’s bid to force arbitration—this time on different grounds. Another case featuring returning counsel is the latest census dispute to hit the high court, Trump v. New York. New York Solicitor General Barbara Underwood and the ACLU’s Dale Ho will partner again to challenge the Trump administration’s handling of the 2020 census. Their first bid in 2019 resulted in a 5-4 ruling finding that the administration could add a citizenship question to the 2020 census but hadn’t given a good enough reason for doing so. The given explanation—that it was necessary to enforce the Voting Rights Act—"seems to have been contrived,” Chief Justice John Roberts wrote in Department of Commerce v. New York. Earlier this term, the census came before the justices on their “shadow docket"—the emergency applications and often unsigned orders asking for relief from lower court rulings. That ruling, Ross v. National Urban League, allowed the administration to stop counting for the census early. Census 3.0—which will kick off the December sitting on Nov. 30—involves the administration’s plan to exclude undocumented immigrants from the determination of how many representatives each state gets in the U.S. House. Underwood and Ho will face off against Acting Solicitor General Jeffrey Wall. Repeat cases involving the census occur because the executive branch has made it a priority, Elwood said. Natural Repetition “Some of this repetition is natural, because a few cases depended on decisions from last term,” Boden said. For example, in a quirky lineup last term in Ramos v. Louisiana, the justices said serious criminal convictions must be obtained by unanimous juries. Edwards v. Vannoy, which the justices will hear Dec. 2, asks whether that ruling applies retroactively—that is, does it apply to convictions handed down prior to the court’s decision in Ramos. Other times, issues come back to the court “because the area of law is particularly important and involves a lot of cases,” Elwood said. He pointed to the Telephone Consumer Protection Act, which is at the center of two recent Supreme Court cases—one last term and another before the justices on Dec. 8. The popular legislation seeks to cut down on the dizzying number of “robocalls” that interrupted dinner tables across America. In Barr v. American Association of Political Consultants, the justices struck down an exception to the TCPA’s robocall prohibition. This term in Facebook v. Duguid, the justices will consider what counts as an “automatic telephone dialing system” for purposes of making robocalls. Finally, issues may frequently come back to the court when a particular one interests the justices, Elwood said. The current court is focused largely on religious cases dealing with free exercise, Elwood said. During the years when Anthony Kennedy and Sandra Day O’Connor sat on the court, it was free speech. And under Chief Justice William Rehnquist, it was federalism. In addition to free exercise cases, the current court has taken several involving separation of powers and the so-called unitary executive. Last term in Seila Law v. Consumer Financial Protection Bureau, the justices said Congress went too far trying to insulate the head of the agency from political pressure. The president has broad power over federal agencies, the court said. There is yet another challenge to the structure of an agency this term—this time, the Federal Housing Finance Agency in Collins v. Mnuchin. And the justices will continue their decade-long quest to rein in the use of the once-dormant Alien Tort Statute, which gives federal courts the authority to hear certain cases brought by foreign nationals. Its use exploded in the early 2000s after the court suggested that it could be used to sue over human rights abuses that occur abroad. Since 2012, the court has cut back on that, saying that there’s a presumption of extraterritoriality that prevents domestic laws from applying outside the U.S., in Kiobel v. Royal Dutch Petroleum. In 2018, the court followed up by saying that foreign corporations couldn’t be sued in the U.S. under the Alien Tort Statute. Now in Nestle v. Doe, the court will consider whether victims and their families can sue U.S. corporations for human rights abuses—here, allegations of child slavery related to the cocoa trade. Though not unprecedented, there are a lot of reasons why repeat cases have converged this term. But “perhaps some repetition was also deliberate,” Boden said. The “Court may have wanted a quieter docket following the blockbuster cases last term.” To contact the reporter on this story: Kimberly Strawbridge Robinson in Washington at krobinson@bloomberglaw.com To contact the editors responsible for this story: Seth Stern at sstern@bloomberglaw.com; John Crawley at jcrawley@bloomberglaw.com Kimberly Strawbridge Robinson Arnold & Porter Kaye Scholer Paul Weiss Henry Schein Inc mandatory arbitration provisions	cc/2021-04/en_middle_0036.json.gz/line1013
__label__wiki	0.861505	0.861505	By Flying Officer Evita Ryan Queensland Fire and Emergency Services officer Sam Eitz, left, receives an ADFA cap from Director Education and Training Group Captain Jeff Howard. Photo: Dan Pinhorn It was the busiest time of year for the Australian Defence Force Academy (ADFA) and Royal Military College – Duntroon (RMC), but when the calls came to accommodate hundreds of firefighters, SES personnel, transiting ADF members and even a childcare centre, the Duntroon Garrison team launched a massive coordinated effort to make sure their guests had everything they would need. Within a day, the ADFA gymnasium facilities at Campbell, ACT, were set up to accommodate 350 people, with the nearby RMC ready to accommodate an additional 76. “To the best of my knowledge, nothing like this has ever been done before at ADFA or RMC,” ADFA executive officer Lieutenant Commander Jon Little, said. “We hired portable showers and toilets, acquired towels and linen so that everyone had a towel, sheets and as many blankets as they wanted,” he said. Working through a roster system, ADFA trainee officers were utilised to provide a central point of contact for the guests. The trainee Officers undertook these roles in addition to assisting ADFA Staff with the Year One Familiarisation Training of 360 new Officers. “It was great to watch our trainee officers apply theoretical lessons in practical applications,” Lieutenant Commander Little said. “They were required to develop last-minute solutions to uncommon problems, such as dietary requirements presented on the day and pharmacy scripts that needed to be filled late at night when firefighters returned from duty. “The firefighters, with some being former ADF members, shared their stories and gave the trainees life experiences that we could never give them." The trainees also escorted groups of guests to the cadet’s mess, which was in itself a massive coordinated effort. “So that we could rotate everyone through, groups had set times to eat at the mess,” Lieutenant Commander Little said. “All nine Canberra messes provided cut lunches and hot boxes to firefighters if they didn’t have the opportunity to eat at the mess." In total, Canberra messes provided 14,960 meals in support of Operation Bushfire Assist. Before the last contingent of firefighters departed the ADFA on February 10, ADF Director Education and Training Group Captain Jeff Howard presented Rural Fire Service Queensland officer Sam Eitz with a cap as a token of appreciation in front of 36 departing firefighters. “Honestly, I don’t think anymore could have been done for us,” Mr Eitz said. “Any questions, any issues we had was met with ‘yes we can get that done’ or ‘yep, we’ll make that happen’ so we felt supported by everyone around us.” “We can’t thank everyone enough for everything that was done for us while we were there." Operation Bushfire Assist 2019-2020 LATEST UPDATE TO ADF'S BUSHFIRE RECOVERY EFFORTS	cc/2021-04/en_middle_0036.json.gz/line1014
__label__wiki	0.846194	0.846194	Women in IT gain ground at Harvard What is an American? The Harvard Women in Technology + Allies Mentoring Program brought together Astride Lisenby (left) and her mentee Nancy Jagaselvan. “This program has opened new doors of opportunity,” said Jagaselvan. Photos by Kris Snibbe/Harvard Staff Photographer Volunteers provide mentorship, support through new initiative By Gray Milkowski Harvard Correspondent Date December 3, 2019 December 5, 2019 It’s no secret that today’s information technology (IT) sector is booming. Over the next 10 years, the field is projected to add more than 500,000 jobs in the U.S. alone. Yet despite that, women account for only about 26 percent of the IT workforce, according to the National Center for Women and Information Technology. At Harvard, 35 percent of women make up the IT workforce, based on 2019 statistics provided by Harvard Women in Technology + Allies (HarvardWIT+). Working to increase that number is a staff-led community of volunteers from the Harvard Women in Technology + Allies Mentoring Program, an initiative of the broader HarvardWIT+ organization. Launched in 2018, the mentoring program began as a pilot after receiving money from the President’s Administrative Innovation Fund. At its core, the program’s objective is to make Harvard a more engaged and inclusive community by increasing retention and promotion of those in IT roles, providing coaching and career-development tools, and empowering members in their workspace. The pilot graduated 20 pairs of mentors and mentees across 16 different Harvard units this past May, and is continuing with the support of University CIO Anne Margulies and Harvard University IT (HUIT). The mentoring program sought additional mentors and mentees at the beginning of the academic year and paired them based on targeted questions in the applications. A second cohort was accepted in October and will meet for the first time on Wednesday. “The program had some immediate tangible results, with two of our mentees receiving promotions and giving credit to the support and encouragement of their mentors,” said Donna Tremonte, HarvardWIT+ founder and IT service delivery lead and engagement manager for the Harvard Kennedy School. “Mentorship is key to career advancement, and HarvardWIT+ is glad to facilitate these connections across the University.” HarvardWIT+ founder Donna Tremonte (left) with Sandy Silk, who leads the mentoring program. Sandy Silk, mentor program lead and Harvard’s director of information security education and consulting, also noted that career progression was only one facet of the program’s success. “When we compared pre- and post-program survey responses, we measured an 82 percent increase in feeling supported to explore a next career step and a 67 percent increase in confidence to self-advocate,” she said. “Participants said the mentoring program gave them the support and confidence to take the chance on themselves.” Extending beyond the numbers, the positive impact the program has on the community can be seen most vibrantly through its mentors and mentees. Astride Lisenby, associate director for Enterprise Systems and Services at Harvard Business School, and her mentee, Nancy Jagaselvan, senior business systems analyst for HUIT, talked about how their partnership through the program has been beneficial. “This program has opened new doors of opportunity,” Jagaselvan said. “Astride understood the struggles and challenges that I encounter at work as a minority woman, and provided excellent insights from her own experience.” Lisenby had equal praise for the program and her mentee. “When the call was sent out for mentors for the WIT+ program I answered it with great optimism that I would be able to be helpful to someone else on their career path,” she said. “My challenges and struggles as well as my successes have given me a broad perspective on career development. I’ve greatly enjoyed the opportunity to share some of that with Nancy and be a sounding board for her challenges.” Members of the community who would like to participate in future mentoring cohorts can visit the initiative’s webpage. Jessica Lander and former students Ezequiel Nunez (from left) and Robert Aliganyira tour an exhibition of their project, "We Are America," on view at Gutman Library through Dec. 16.	cc/2021-04/en_middle_0036.json.gz/line1015
__label__wiki	0.539885	0.539885	Home » St Leger » Top celebrity divorce lawyer set to face rare defeat Top celebrity divorce lawyer set to face rare defeat Raymond Tooth is no stranger to winning high-profile divorce cases, representing the wives of male celebrities, with Irina Abramovich, Cheryl Barrymore and Sadie Frost among his clients. Meanwhile, success on the racecourse has also been enjoyed previously, with Tooth owning 2009 Champion Hurdle victor Punjabi and French Group 1 winner French Fifteen, who then went on to finish second in the 2,000 Guineas last year behind Camelot. However, this is as close as he has come to a victory in one of the English Classics, but he has another opportunity to succeed in this particular field when Great Hall lines up in the St Leger. Unfortunately, he looks to be facing a losing battle this time and it is hard to get overly excited about Great Hall’s St Leger price of 25/1, even from an each-way viewpoint. Firstly, there is no horse with a lower Official Rating (98) or Racing Post Rating (115) in the field and 119 has been the lowest RPR of any of the St Leger winners of the last decade. Secondly, Great Hall has never previously competed out of handicap company and his lack of Group-level experience is far from ideal. Eight of the last 10 St Legers arrived having won a Group race and the two exceptions had at least finished second in one. Thirdly, all of these winners were not only successful on their racecourse debuts, but these maiden victories were over a distance no shorter than 7f. Great Hall was only seventh of 10 on his debut, with the only crumb of comfort coming from the fact that the winner was Havana Beat, who is also running in the St Leger. The only other slight positives that can be clutched are that Kieren Fallon will be on board at Doncaster, who rode Great Hall to victory last time and needs to win the St Leger to complete his own English Classics set. Meanwhile, unlike many of the other entrants, Great Hall has experience of the 1m6f trip, having won over the distance on his last start. Fancy a flutter? Sign up today to claim three £10 free bets when you bet £10 « Ladbrokes #StLeger6 competition St Leger betting » Masked Marvel to provide Gosden with another St Leger winner Camelot to win St Leger, money coming for Ursa Major Ben Stones \| 11.09.2015 5 Channel 4 racing pointers to remember on St Leger weekend	cc/2021-04/en_middle_0036.json.gz/line1016
__label__wiki	0.529832	0.529832	New Microsoft Technology Center opens in Houston, highlights global commitment to empower customers By Vanessa Ho 26 February, 2016 Microsoft News Center Staff Microsoft celebrated the grand opening of a new Microsoft Technology Center in Houston this week, highlighting the company’s commitment to empowering customers worldwide with innovative technologies, solutions and expertise. With nearly 40 locations around the world, Microsoft Technology Centers (MTCs) offer collaborative environments and hands-on experiences where customers can try out the latest cloud-powered solutions driving business transformation, including innovative technologies like Windows 10 and Surface Hub. The centers feature interactive demos, immersive experiences, theater-like settings for envisioning scenarios and tailored sessions for building solutions that meet customer goals. They also offer strategy briefings, proof-of-concept workshops and architectural design sessions, with access to partner technologies and time to try out the latest tools in cloud productivity, mobility, secure computing and other business needs. The Envisioning Center inside the Microsoft Technology Center in Houston. “The MTCs in general are very customer-centric and solution-oriented,” said Nick Kritikos, national director of Microsoft Technology Centers in North America. “Customers come to the MTC not to buy something or get sold something, but to understand how they can transform their business using Microsoft’s innovative technology and do it as a partner.” Craig Hodges, general manager of Microsoft Gulf Coast District Enterprise and Partner Group, speaks at the grand opening of the Microsoft Technology Center in Houston on Feb. 24, 2016. The centers enable local customers to work firsthand on creating technology solutions that will optimize and grow their business and, in turn, fuel innovation and the local economy. All Microsoft-managed commercial and public sector customers can use MTCs to envision how Microsoft solutions can allow them to get their work done across different locations and devices. “It literally is a technology toy box, where customers can come in and touch it and see how it works. It’s not just a PowerPoint presentation or a bunch of talking,” said Kritikos. “Customers can roll up their sleeves and do it themselves, so they can develop their own understanding.” Houston’s new 12,600-square-foot facility is Microsoft’s first cloud-based MTC, with a small data center and prominent showcase of Microsoft Azure cloud platform and services. The center also operates as an Oil & Gas Center of Excellence, specializing in technologies designed for energy companies, many of which are based in Houston and the Gulf Coast region. “I am really excited to bring industry-relevant solutions to our customers, right in the place where they conduct their business,” said Muge Wood, director of the Microsoft Technology Center in Houston. “That is something we have not really been able to do in the past (in Houston). Being able to bring that relevancy to help our customers envision what’s possible with our platform, specific to their industry verticals, is most exciting.” Solutions for oil and gas customers include Azure Machine Learning for predictive analytics and forecasting equipment failure, making maintenance and repairs in the field more efficient. Skype and Office 365 can help a company’s command center connect with field engineers to collaboratively and remotely troubleshoot problems. And Microsoft Dynamics can help track service requests and send feedback to predictive analytics models. The Houston MTC also features partner solutions designed for the energy industry, including a camera from Bartec that mounts on a hardhat for hands-free video streaming. A well monitoring solution from oilfield services company Baker Hughes provides real-time indicators and dashboards for greater, faster insight. And a solution from Rockwell Automation leverages Azure to collect signals from the field and provide intelligent views. “Ultimately, success to me is when our customers walk away and say, ‘We did not know this was possible with what we owned or considered investing in, and we are excited about what this can do for our business in the way we work, collaborate and get insights from our data. It showed us a new way to get things done,’” said Wood. “That is really the highlight of our day.” A Baker Hughes employee showcases the company’s FieldPulse analytics software on a Surface Hub in the Interactive Center of the Microsoft Technology Center in Houston. She said many solutions transcend industries and regions, including field technologies that can help processing and manufacturing customers. Similarly, solutions featured in other MTCs also have wide appeal, including healthcare solutions from the Boston MTC, retail technologies from Minneapolis, and financial and media services from New York. Microsoft Technology Centers also support an entire customer’s life cycle, with technical support post-sale. And they provide ongoing education in technology, through increasingly popular webinars from their studios and community events for youths. “All customers are welcome,” Kritikos said. “Whether they want to engage us through the MTC Studio from their own desk, want to come in themselves, or want to bring their Girl Scout troop to get inspired by Microsoft technology, they’re welcome. It’s Microsoft’s commitment to help local businesses and the community prosper.” Learn more about Microsoft Technology Centers. Lead photo: The Microsoft Technology Center Houston team.	cc/2021-04/en_middle_0036.json.gz/line1017
__label__wiki	0.915161	0.915161	Cars: British firm invents £9,000 kit for converting classic Minis into all-electric vehicles Classic Minis can be made into all-electric vehicles thanks to a conversion kit developed by a British firm that replaces the engine of the iconic car. Wiltshire-based Swindon Powertrain says that the £9,000 kit — which includes an electric motor and gearbox — can be fitted by most amateur mechanics. Also required, however, are a battery as well as a AC-DC converter and charger — which are sold separately, for £16,000 and £1,950, respectively. At the moment, the conversion system is designed specifically to fit the engine bay of a Mini — but could be adapted in future to aid any classic car, the designers said. The development comes just a week after the UK Government announced that the sale of new diesel and petrol vehicles will be banned from 2030 onwards. Experts believe that all second-hand cars and classic vehicles will end up being driven off the road — metaphorically speaking — in the not-to-distant future. However, the conversion kit will allow owners of all classic Minis, at least, to keep on motoring in their beloved cars in an eco-friendly way long into the future. However, the car’s distinctive high-pitched revs — as famously immortalised in the 1969 film The Italian Job — will be lost to the near-silence of the electric engine. The British Motor Company released the first Mini model back in 1959 — with the tiny, two-doored economy vehicle going on to become an icon of 60s UK culture. ‘Hang on lads, I’ve got a great idea’: Classic Minis can be made into all-electric vehicles, as pictured, thanks to a conversion kit developed by a British firm that replaces the car’s engine Wiltshire-based Swindon Powertrain says that the £9,000 kit — which includes an electric motor and gearbox, pictured — can be fitted by most amateur mechanics. Also required, however, are a battery as well as a AC-DC converter and charger — which are sold separately, for £16,000 and £1,950, respectively The conversion works by replacing the standard Mini engine with an electric powered motor and gearbox, mounted on a sub-frame that sits on the chassis. Electrical power comes from a 12kWhr battery, placed on top of the motor, which gives the car a range of up to 125 miles and can be mains charged in five hours. The direct current supplied by the battery is passed through an AC–DC converter, which then supplies energy to the front wheels to propel the car. ‘This is a system that basically replaces the petrol engine in a Mini and makes it completely electric,’ said Swindon Powertrain managing director Raphaël Caillé. ‘It is aimed at people who own these classic cars and want to carry on driving them for years to come.’ ‘Already, if you own a 1980 Mini there are certain parts of London that you can’t drive it in because of emissions.’ ‘With this not only can you take it where you like, but it is exempt from the congestion charge.’ ‘The standard kit has a range of about 50 miles and while that might not sound like much, it’s about as far as people tend to go in these Minis.’ ‘Charging can be done using a standard plug and takes about five hours.’ At the moment, the conversion system is designed specifically to fit the engine bay of a Mini, pictured — but could be adapted in future to aid any classic car, the designers said The development comes just a week after the UK Government announced that the sale of new diesel and petrol vehicles will be banned from 2030 onwards. Experts believe that all second-hand cars and classic vehicles will end up being driven off the road — metaphorically speaking — in the not-to-distant future. Pictured, an electric-converted Mini The conversion kit will allow owners of all classic Minis, at least, to keep on motoring in their beloved cars in an eco-friendly way long into the future. However, the car’s distinctive high-pitched revs — as famously immortalised in the 1969 film The Italian Job (pictured) — will be lost to the near-silence of the electric engine The British Motor Company released the first Mini model back in 1959 — with the tiny, two-doored economy vehicle going on to become an icon of 60s UK culture ‘We launched the product last week and Boris Johnson made his announcement a few days later — it’s almost like we pushed him into action!’ Mr Caillé joked. ‘I don’t know if this is something that would work for all classic cars but the potential is there,’ he added. ‘Of course there are some cars that have beautiful engines that should be preserved — but it could be that electric conversion is the only way to keep them on the roads.’ The conversion works by replacing the standard Mini engine with an electric powered motor and gearbox, pictured, mounted on a sub-frame that sits on the chassis Electrical power comes from a 12kWhr battery, placed on top of the motor, which gives the car a range of up to 125 miles and can be mains charged in five hours The development has already been welcomed by some Mini enthusiasts. ‘I think it’s a fantastic evolution and will help keep classics on the road many years after legislation has removed our right to internal combustion engine cars,’ said Bil Bell, who runs the ‘1959 Mini Register’ that tracks the earliest iterations of the car. ‘It wouldn’t be right for all classic cars, and not my first choice — but if electrification allows enthusiasts to keep classic vehicles as a hobby then I’m in favour.’ Colombia confirms that dreaded fungus has hit its banana plantations Banana plantations in Colombia, such as this one, are facing risks from a deadly fungus. iStock/mg81 By Sabine GalvisAug. 12, 2019 , […] Catapulting spider winds up web to launch itself at prey: study Washington (AFP) – Just when you thought spiders couldn’t get any more terrifying. A study published Monday has found that an arachnid […] ISS news: Rebooted CIMON-2 floating robot returns to International Space Station The new robot assistant can show and explain information and instructions for scientific experiments and repairs, allowing astronauts to keep their hands […] ‘MONSTROUS’ scientist ‘makes world’s first gene-edited babies’ in HIV test He Jianhui, a scientist at the Southern University of Science and Technology in Shenzhen, believes he has altered the DNA of twin […] How To Choose the Best Custom Cover for Your Truck White House DENIES Trump is heading to Scotland to flee inauguration after Sturgeon swipe Democrat Raphael Warnock claims victory in Georgia Senate runoff U.S. House Republican Kevin Brady tests positive for COVID-19 WhatsApp users warned as 'Argentina is doing it' message spreads on iPhone and Android For media following Georgia, nail-biting and lots of numbers Dr. Dre Hospitalized in ICU After Suffering Brain Aneurysm Inside Kim and Kanye's Marital Woes: Their 'Views No Longer Line Up' Raphael Warnock wins Georgia runoff, CNN projects, as control of US Senate down to Perdue-Ossoff race Neil Young becomes latest artist to sell stake in his songs South Korea rolls out mass testing for 70,000 prisoners and staff And Now For An Architectural Criticism Of Cyberpunk 2077 Previous post Joe Root on seven-man shortlist for ICC Male Cricketer of the Decade Next post Socialite takes six pregnant women to Nigerian wedding White House DENIES Trump is heading to Scotland to… 2-for-1: Total lunar eclipse came with a super moon bonus	cc/2021-04/en_middle_0036.json.gz/line1022
__label__cc	0.597121	0.402879	NYC DOT Clarifying Muni-Meter Parking Rules Filed Under:Department of Transportation, Glenn Biloffski, Muni Meter, Rich Lamb Muni-meter (DNAInfo.com) NEW YORK (CBSNewYork) — The rules for parking at Muni-Meters in New York City may soon be changing. LISTEN: WCBS 880’s Rich Lamb reports https://newyork.cbslocal.com/wp-content/uploads/sites/14578484/2012/01/muni.mp3 Currently, rules say if you’ve purchased a Muni-Meter ticket for your parked car and leave the space with time remaining on the receipt, you can then park in another Muni-Meter space in the city and use the minutes remaining on your ticket. Now, the Department of Transportation says it’s clarifying the rules so that you may only use the excess time at another Muni-Meter spot of exactly the same price. “So for example, if you spend $6 on meters in Manhattan for two hours but go to Brooklyn, where it’s maybe $4, they won’t allow you to use it,” said Glenn Biloffski of ParkingTicket.com. But the DOT says it’s concerned that drivers will buy a meter receipt in a cheap area of the city and then use it in a pricier spot. Brooklyn Assemblyman William Colton said the new policy is even more confusing than the older one. “They’re reinstituting the confusion, this shell game, where the motorist can not be sure whether or not they can use the receipt or not. That is unfair, it lacks transparency and basically it adds to confusion which causes the motorist to feel they are being ripped off,” Colton told 1010 WINS. The DOT released a statement Tuesday afternoon saying “We are in the process of updating the rules to make clearer that Muni-Meter receipts may be used at additional locations, provided those areas have the same parking rates and regulations.” For more information about Muni-Meters, click here.	cc/2021-04/en_middle_0036.json.gz/line1023
__label__cc	0.694746	0.305254	Biden Arrives In Washington On Eve Of InaugurationPresident-elect Joe Biden arrived in Washington, D.C., on Tuesday ahead of his inauguration, heading to the Lincoln Memorial for a ceremony honoring the 400,000 Americans who have died of COVID-19. Police: Woman Bitten, Robbed By Men After Argument At Harlem Liquor StoreThree men allegedly assaulted the woman, kicking her multiple times. Police say one man bit the woman on her forehead. Long Beach Residents Rally Against Port Ambrose Natural Gas Terminal Filed Under:Ambrose Terminal, Carol D'Auria, Denise Ford, Governor Cuomo, Kathleen Rice, long beach, Natural Gas LONG BEACH, N.Y. (CBSNewYork) — Long Beach residents have rallied in the past against Port Ambrose, this time they did it with the help of their elected officials. Congresswoman Kathleen Rice said the risk of a liquefied natural gas terminal off the coast would be too much a burden for Long Beach which still hasn’t finished recovering from Superstorm Sandy. The terminal would be located 17 nautical miles off the coast of Jones Beach. The proposal is currently in its public comment period. Nassau County Legislator Denise Ford said there are better alternatives. “We can build a beautiful wind farm that will provide much needed jobs for our union brothers and sisters. We call upon Governor (Andrew) Cuomo to join us in the fight against this,” Ford said. If Port Ambrose is built it would provide natural gas for New York City and Long Island. You May Also Be Interested In These Stories	cc/2021-04/en_middle_0036.json.gz/line1024
__label__cc	0.663897	0.336103	Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells Christopher J. Hanrahan, Manny D. Bacolod, Rajeev R. Vyas, Tongming Liu, Nicholas E. Geacintov, Edward L. Loechler, Ashis K. Basu In the supF gene, most (+)-anti-benzo[a]pyrene diol epoxide ((+)-anti- B[a]PDE) mutagenesis hot spots in Escherichia coli are in 5'-GG sequences [Rodriguez and Loechler (1993) Carcinogenesis 14, 373-383]. A major hot spot was detected at G1 in the sequence 5'-GCG1G2-CCAAAG, whereas G2 yielded very few mutants. In order to investigate the details of such sequence context effects of (+)-anti-B[a]PDE mutagenesis, we have constructed 25-mer oligonucleotides and single-stranded M13 genomes containing the above decamer sequence, in which the trans-N2-dG adduct induced by (+)-anti-B[a]PDE [(+)- trans-anti-B[a]P-N2-dG] at G1 or G2 was introduced. In vitro DNA synthesis on the adducted 25-mers was strongly blocked at each site, although the 3' → 5' exonuclease-deficient Klenow fragment could incorporate a nucleotide opposite the adduct in the presence of Mn2+. For both sites purine nucleotides were preferred. The ratio V max/Km indicated that the efficiency of incorporation of dGTP opposite these sites was very similar, but dATP incorporation opposite the adduct at G1 was five-fold more efficient than that at G2. For each site, further extension beyond the adducted nucleotide was investigated by annealing four different primers, in which only the nucleotide opposite the adducted deoxyguanosine was altered. Significant extension was only observed when deoxyadenosine was located opposite adducted G1. When the M13 genomes containing the (+)-trans-anti-B[a]P-N2-dG were replicated in E. coli, survival of each adducted genome was less than 1% as compared to the unadducted genome. Upon induction of SOS, viability increased 2-6-fold. DNA sequencing showed no base substitutions in the progeny from SOS-uninduced cells, although small deletions in a quasipalindromic sequence occurred with the adduct being located at either site. However, following SOS induction, up to 40% targeted base substitutions were detected when the adduct was located at G1, while ~12% of the progeny were mutants with the adduct at G2. Most base substitutions were targeted GT transversions. We conclude that (+)-trans-anti-B[a]P-N2-dG is a highly mutagenic and replication blocking lesion. In addition, the biological consequence of this adduct depends on whether it is located at G1 or G2, suggesting that sequence context plays a major role in the mutagenic processing of this adduct. Chemical research in toxicology https://doi.org/10.1021/tx9601925 10.1021/tx9601925 Fingerprint Dive into the research topics of 'Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells'. Together they form a unique fingerprint. benzo(a)pyrene N2-dG adduct Medicine & Life Sciences Mutagenesis Chemical Compounds Epoxy Compounds Medicine & Life Sciences Escherichia coli Chemical Compounds DNA Adducts Medicine & Life Sciences Benzo(a)pyrene Medicine & Life Sciences SOS Response (Genetics) Medicine & Life Sciences Hanrahan, C. J., Bacolod, M. D., Vyas, R. R., Liu, T., Geacintov, N. E., Loechler, E. L., & Basu, A. K. (1997). Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells. Chemical research in toxicology, 10(4), 369-377. https://doi.org/10.1021/tx9601925 Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells. / Hanrahan, Christopher J.; Bacolod, Manny D.; Vyas, Rajeev R.; Liu, Tongming; Geacintov, Nicholas E.; Loechler, Edward L.; Basu, Ashis K. In: Chemical research in toxicology, Vol. 10, No. 4, 04.1997, p. 369-377. Hanrahan, CJ, Bacolod, MD, Vyas, RR, Liu, T, Geacintov, NE, Loechler, EL & Basu, AK 1997, 'Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells', Chemical research in toxicology, vol. 10, no. 4, pp. 369-377. https://doi.org/10.1021/tx9601925 Hanrahan CJ, Bacolod MD, Vyas RR, Liu T, Geacintov NE, Loechler EL et al. Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells. Chemical research in toxicology. 1997 Apr;10(4):369-377. https://doi.org/10.1021/tx9601925 Hanrahan, Christopher J. ; Bacolod, Manny D. ; Vyas, Rajeev R. ; Liu, Tongming ; Geacintov, Nicholas E. ; Loechler, Edward L. ; Basu, Ashis K. / Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells. In: Chemical research in toxicology. 1997 ; Vol. 10, No. 4. pp. 369-377. @article{bf2dcfa28fd74467bf4a5eb0190bbc11, title = "Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells", abstract = "In the supF gene, most (+)-anti-benzo[a]pyrene diol epoxide ((+)-anti- B[a]PDE) mutagenesis hot spots in Escherichia coli are in 5'-GG sequences [Rodriguez and Loechler (1993) Carcinogenesis 14, 373-383]. A major hot spot was detected at G1 in the sequence 5'-GCG1G2-CCAAAG, whereas G2 yielded very few mutants. In order to investigate the details of such sequence context effects of (+)-anti-B[a]PDE mutagenesis, we have constructed 25-mer oligonucleotides and single-stranded M13 genomes containing the above decamer sequence, in which the trans-N2-dG adduct induced by (+)-anti-B[a]PDE [(+)- trans-anti-B[a]P-N2-dG] at G1 or G2 was introduced. In vitro DNA synthesis on the adducted 25-mers was strongly blocked at each site, although the 3' → 5' exonuclease-deficient Klenow fragment could incorporate a nucleotide opposite the adduct in the presence of Mn2+. For both sites purine nucleotides were preferred. The ratio V max/Km indicated that the efficiency of incorporation of dGTP opposite these sites was very similar, but dATP incorporation opposite the adduct at G1 was five-fold more efficient than that at G2. For each site, further extension beyond the adducted nucleotide was investigated by annealing four different primers, in which only the nucleotide opposite the adducted deoxyguanosine was altered. Significant extension was only observed when deoxyadenosine was located opposite adducted G1. When the M13 genomes containing the (+)-trans-anti-B[a]P-N2-dG were replicated in E. coli, survival of each adducted genome was less than 1% as compared to the unadducted genome. Upon induction of SOS, viability increased 2-6-fold. DNA sequencing showed no base substitutions in the progeny from SOS-uninduced cells, although small deletions in a quasipalindromic sequence occurred with the adduct being located at either site. However, following SOS induction, up to 40% targeted base substitutions were detected when the adduct was located at G1, while ~12% of the progeny were mutants with the adduct at G2. Most base substitutions were targeted GT transversions. We conclude that (+)-trans-anti-B[a]P-N2-dG is a highly mutagenic and replication blocking lesion. In addition, the biological consequence of this adduct depends on whether it is located at G1 or G2, suggesting that sequence context plays a major role in the mutagenic processing of this adduct.", author = "Hanrahan, {Christopher J.} and Bacolod, {Manny D.} and Vyas, {Rajeev R.} and Tongming Liu and Geacintov, {Nicholas E.} and Loechler, {Edward L.} and Basu, {Ashis K.}", doi = "10.1021/tx9601925", journal = "Chemical Research in Toxicology", T1 - Sequence specific mutagenesis of the major (+)-anti-benzo[a]pyrene diol epoxide-DNA adduct at a mutational hot spot in vitro and in Escherichia coli cells AU - Hanrahan, Christopher J. AU - Bacolod, Manny D. AU - Vyas, Rajeev R. AU - Liu, Tongming AU - Geacintov, Nicholas E. AU - Loechler, Edward L. AU - Basu, Ashis K. N2 - In the supF gene, most (+)-anti-benzo[a]pyrene diol epoxide ((+)-anti- B[a]PDE) mutagenesis hot spots in Escherichia coli are in 5'-GG sequences [Rodriguez and Loechler (1993) Carcinogenesis 14, 373-383]. A major hot spot was detected at G1 in the sequence 5'-GCG1G2-CCAAAG, whereas G2 yielded very few mutants. In order to investigate the details of such sequence context effects of (+)-anti-B[a]PDE mutagenesis, we have constructed 25-mer oligonucleotides and single-stranded M13 genomes containing the above decamer sequence, in which the trans-N2-dG adduct induced by (+)-anti-B[a]PDE [(+)- trans-anti-B[a]P-N2-dG] at G1 or G2 was introduced. In vitro DNA synthesis on the adducted 25-mers was strongly blocked at each site, although the 3' → 5' exonuclease-deficient Klenow fragment could incorporate a nucleotide opposite the adduct in the presence of Mn2+. For both sites purine nucleotides were preferred. The ratio V max/Km indicated that the efficiency of incorporation of dGTP opposite these sites was very similar, but dATP incorporation opposite the adduct at G1 was five-fold more efficient than that at G2. For each site, further extension beyond the adducted nucleotide was investigated by annealing four different primers, in which only the nucleotide opposite the adducted deoxyguanosine was altered. Significant extension was only observed when deoxyadenosine was located opposite adducted G1. When the M13 genomes containing the (+)-trans-anti-B[a]P-N2-dG were replicated in E. coli, survival of each adducted genome was less than 1% as compared to the unadducted genome. Upon induction of SOS, viability increased 2-6-fold. DNA sequencing showed no base substitutions in the progeny from SOS-uninduced cells, although small deletions in a quasipalindromic sequence occurred with the adduct being located at either site. However, following SOS induction, up to 40% targeted base substitutions were detected when the adduct was located at G1, while ~12% of the progeny were mutants with the adduct at G2. Most base substitutions were targeted GT transversions. We conclude that (+)-trans-anti-B[a]P-N2-dG is a highly mutagenic and replication blocking lesion. In addition, the biological consequence of this adduct depends on whether it is located at G1 or G2, suggesting that sequence context plays a major role in the mutagenic processing of this adduct. AB - In the supF gene, most (+)-anti-benzo[a]pyrene diol epoxide ((+)-anti- B[a]PDE) mutagenesis hot spots in Escherichia coli are in 5'-GG sequences [Rodriguez and Loechler (1993) Carcinogenesis 14, 373-383]. A major hot spot was detected at G1 in the sequence 5'-GCG1G2-CCAAAG, whereas G2 yielded very few mutants. In order to investigate the details of such sequence context effects of (+)-anti-B[a]PDE mutagenesis, we have constructed 25-mer oligonucleotides and single-stranded M13 genomes containing the above decamer sequence, in which the trans-N2-dG adduct induced by (+)-anti-B[a]PDE [(+)- trans-anti-B[a]P-N2-dG] at G1 or G2 was introduced. In vitro DNA synthesis on the adducted 25-mers was strongly blocked at each site, although the 3' → 5' exonuclease-deficient Klenow fragment could incorporate a nucleotide opposite the adduct in the presence of Mn2+. For both sites purine nucleotides were preferred. The ratio V max/Km indicated that the efficiency of incorporation of dGTP opposite these sites was very similar, but dATP incorporation opposite the adduct at G1 was five-fold more efficient than that at G2. For each site, further extension beyond the adducted nucleotide was investigated by annealing four different primers, in which only the nucleotide opposite the adducted deoxyguanosine was altered. Significant extension was only observed when deoxyadenosine was located opposite adducted G1. When the M13 genomes containing the (+)-trans-anti-B[a]P-N2-dG were replicated in E. coli, survival of each adducted genome was less than 1% as compared to the unadducted genome. Upon induction of SOS, viability increased 2-6-fold. DNA sequencing showed no base substitutions in the progeny from SOS-uninduced cells, although small deletions in a quasipalindromic sequence occurred with the adduct being located at either site. However, following SOS induction, up to 40% targeted base substitutions were detected when the adduct was located at G1, while ~12% of the progeny were mutants with the adduct at G2. Most base substitutions were targeted GT transversions. We conclude that (+)-trans-anti-B[a]P-N2-dG is a highly mutagenic and replication blocking lesion. In addition, the biological consequence of this adduct depends on whether it is located at G1 or G2, suggesting that sequence context plays a major role in the mutagenic processing of this adduct. U2 - 10.1021/tx9601925 DO - 10.1021/tx9601925 JO - Chemical Research in Toxicology JF - Chemical Research in Toxicology	cc/2021-04/en_middle_0036.json.gz/line1025
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__label__cc	0.616748	0.383252	HDS30-20, trip log, Antarctica - Learning and Discovery by Oceanwide Expeditions 165 foto's van deze in de galerij » Day 1: Embarkation, Ushuaia Positie: 54°48’.6 S, 068°17’.8 W Wind: NE2 Weer: Cloudy Luchttemperatuur: +9 Finally, we arrived in Ushuaia! All of us came to this town in the very south of Argentina from everywhere around the world on an overcast day that was not too cold. Known as ‘the End of the World’, Ushuaia is just the beginning of our adventure as we will venture much further South to the great White Continent. For most of us this is a lifelong dream, and for many, this will be the seventh continent and last continent on the list to visit. However, Ushuaia is not just a port for us; it is a beautiful city set in beautiful landscape. The mountains that rise up from the ocean behind the city are topped with snow, and the streets are buzzing with excitement for those about to embark on the voyage of a lifetime while a silent smell in the air makes it clear to us that winter is not far away anymore. In the morning, we strolled around Ushuaia’s old roads, doing some last-minute shopping and grabbing a coffee before embarking upon the expedition ship M/V Hondius. Finally, it is 4:00pm and we are slowly making our way to our home for the next 10 days, Hondius. Whilst waiting to board, you could feel the excitement in the air. The expedition team greeted us at the gangway and their excitement for the upcoming journey was palpable. We were met at reception by DJ, the ship’s hotel manager, where we then checked into our cabins with the assistance of our fabulous crew. We had a little bit of time to get familiarised with the ship before we all convened in the lounge on deck 5 to formally meet our Expedition Leader, Adam, and our Hotel Manager, DJ, for the first time. They gave us an overview of the ship, a floating hotel with a lot of comfort, and a short introduction of the next couple of days. Then, we met the chief officer, Matei, who led us through all the details of the required SOLAS briefing (Safety of Life at Sea). One last time before dinner, we gathered in the lounge with a glass of Prosecco as it was time for the captain´s welcome cocktail hour. We were introduced to our captain, Remmert Jan Koster, who toasted to a safe and amazing trip. At 19:30 we were welcomed to the dining room, where we sat at shared tables, making new friends and wondering what awaits us in the days to come. Day 2: At sea, Drake Passage Wind: SW6 Weer: Rain Today was our first morning in the infamous Drake Passage. For some, it felt like the swell had woken them up like a baby in a cradle. However, there were some mixed opinions about this, with some much preferring the comforts of a bed on solid ground than at sea. Most people did come down for breakfast, though, which was a great start. After our first delicious breakfast onboard Hondius, we all had to meet up in the Lounge for the introduction of all the expedition staff. After the introductions, Expedition Leader Adam gave us a mandatory IAATO briefing where we learned what we can do and, more importantly, what we can’t do in Antarctica. We also been given the important basics for the zodiac operations, how to use the sailor’s grip, and the use of the life vests that we have to wear when we leave the ship. The briefing was followed by the handing out of the rubber boots. Many shoesizes flew around the room. Regardless of if you need a big size or small size, the expedition staff had a pair of boots with you in no time. Therefore, it also did not take very long until everybody had a pair and was ready to go for lunch. In the afternoon, we had a full program filled with lectures and activity briefings. Martin lectured about his favourite topic, seabirds. Also, on the list was the biosecurity check, where everybody had to bring down their outer clothing, which was thoroughly checked by the expedition staff. All pockets had to be vacuumed and all Velcro straps were checked and cleaned with pincers to ensure that we don’t bring any foreign species with us to the pristine White Continent. After the biosecurity check, some of us headed to the lecture room for the kayaking briefing with Pete and Paul, and the camping briefing with Ben and Marcel, for those who had signed up for some adventurous activities in Antarctica. To end the day, we had our first Daily Recap in the observation lounge. Here, we got to hear the plans for the next day from our expedition leader Adam while some of the expedition staff had some interesting topics to educate us all about to end the day. Directly after dinner, we saw an amazing sunset over the Drake Passage, which we were very lucky to see due to the day’s fog and low-lying clouds. In the evening, we had a lecture from Massimo and Myriam, where we were given an introduction to photography in Antarctica. Soon enough, it was time to head to bed to get some rest before yet another busy sea day on the Drake Passage. Wind: NW2 Weer: Overcast During the night, we sailed through the Antarctic Convergence and when you got on the outside decks, the cold chill in the air reminded you that we were sailing ever closer to the Antarctic Peninsula. We expected some more sea birds, but probably because of the calm sea, there were not that many birds, as many of the birds of the Southern Ocean depend on high winds to soar across the open seas. But most people felt very good due to the calm seas and most of us had a delicious breakfast. During breakfast there was an announcement about a contest: when will we see the first iceberg? After yesterday’s mandatory briefings, we had a day full of interesting lectures. We first gathered in the lounge to hear Gaby tell us about the glaciology. We learned about glaciers and ice so we are able to read the landscape when we will reach the White Continent. Just before lunch, Sara took us on a visual journey of the different penguins we can see and discussed the many adaptation penguins have to survive in such a harsh environment. Then it was time for the lovely lunch buffet. During lunch, the fog came in and as we were completely surrounded by the fog, Pippa taught us about marine mammals of Antarctica. During Pippa’s lecture, we learned how to identify different species of whales and dolphins while also getting a closer look in some scientific research programs. In the afternoon, our two resident acoustics scientists, Morgan and Sara, told us about their research and how we can help them on our journey to Antarctica. During our voyage, we will all be able to see how they work and what they are able to record for future publication into scientific journals. After all the ice and wildlife information, it was time for Massimo and Myriam to show us how we can make beautiful videos of all the things we will see the coming days in their videography lecture. Before dinner, we gathered in the lounge to hear the plans for tomorrow. It will be a day everybody is waiting for, because after leaving Ushuaia it will be our first outing in the zodiacs or the kayaks. After dinner’s 4-course meal, the kayakers met up with their guides to get a close up look at a kayak, to get familiar with the seats and steering system, and to collect all of the kayaking gear. For the rest of us, it was time to relax. As we sailed further south, the ship rocked throughout the night, but we got more and more excited for the adventures to come in the White Continent. Day: Anagram Islands & Port Charcot Wind: Light After two days heading south through the ‘Drake Lake,’ we arrived at the Antarctic Peninsula with beautiful sunny skies and glassy, calm seas. In true expedition style, we planned to make a landing at the unchartered Anagram Islands, a location that was new for Hondius and the expedition staff. Due to swell conditions, we unfortunately could not make a landing, however, with perfect Antarctic summer conditions around us, we dropped the zodiacs and went for a cruise around the ice and the unexplored islands. This provided the ultimate welcome to Antarctica, with an abundance of wildlife and some truly stunning scenery under the summer sun. We were first provided excellent close up views of crabeater seals, followed by Antarctic fur seals, humpback whales and our first penguins! The afternoon provided us all with the opportunity to finally stretch our legs at Port Charcot, the sight of the 1903-1905 overwintering French expedition led by famed explorer, Jean-Baptiste Charcot. This landing provided us with close-up encounters of gentoo penguins as well as a small number of chinstrap penguins. We had officially ticked off all three of the brush-tail penguins within the first day of our expedition in Antarctica (an achievement that is very rarely achieved). As well as making a landing, we also went out on a zodiac cruise amongst the many towering icebergs found throughout the bay. Tucked amongst the icebergs were numerous species of seal, including crabeater, leopard and Weddell seals. Not only had we now seen all three species of penguin that we were hoping for but also all of the main true seal species as well. We were event treated to some excellent views of Antarctic minke whales and humpback whales from the zodiacs and from Hondius as we returned to the ship at the end of a very rewarding day for another informative recap lecture and dinner. To end the perfect start to our Antarctic expedition, some of us even went out for a night of camping in the evening as the calm summer conditions continued into the ephemeral darkness of the Antarctic night. After a full day of activities and back on Hondius, Ben and Marcel organized the camping for the adventurous people who dared to spend the night out in the wilderness and extreme conditions of Antarctica. We had the chance to have a good meal and time enough to get ready. The zodiac ride wasn’t very short because the best spot the guides could find was on one of the small islands near Pleneau Island and the ship couldn’t get closer due to the depth of the area. Once there the guides briefed us and we started to get ready digging holes and setting up the gear provided. Didn’t take to long but as soon as the sun went down it started to get dark and colder. The timing could not be better, just when everybody was inside of the sleeping bags and after Ben and Marcel checked all us out to see if we were OK and put our boots in the correct way to keep them dry, the drizzle appeared and the temperature kept going down so it didn’t take too long until it became snow and Antarctica showed to us how changeable, unpredictable and extreme can be. Around 4:15 was the wakeup call and the time to get ready for the pickup and as planned the zodiacs were ready loading us at 5 o’clock to go back to the safety and comfort of Hondius to have a warm shower but not before to enjoy the tasty Danish pastries made by the galley team and a hot chocolate at the bar. Day 5: Vernadsky Station, Wordie House & Yalour Islands Wind: S3 Weer: Snowy Once again, we awoke to find ourselves surrounded by the majesty of Antarctica: icebergs, penguins, and the odd humpback whale that floated past the ship as we glided under overcast skies towards our objective for the morning. The Argentine Islands are the location of Ukraine’s Vernadsky scientific research station and Wordie House, the historic station that preceded it. Originally built by the British, these two stations arguably represent the longest continually occupied station complex on the Continent. Wordie House was built in 1947 on Winter Island to replace an earlier structure that was washed away in a tsunami in 1946. In 1955, it was replaced by a larger base just a few hundred meters away on Galindez Island. This latter base was later named Faraday Station. In 1996 it was sold to the Ukraine Government for £1 on the condition that Ukraine would continue a decade’s old program of astrophysical observations. The morning’s program kept us fully occupied as we visited the base, where we received a warm welcome and went on a comprehensive tour of the facility. This was followed by a visit to the gift store and the famous “Faraday Bar” where shots of base-brewed vodka could be traded for cash or donation of a bra! Then, there was a zodiac cruise around the islands and though the region’s many channels, a great habitat for spotting crabeater seals. Finally, we were able to walk through Wordie House, named after James Wordie, the geologist on Shackleton’s Endurance Expedition. Wordie House has been restored to its original state complete with stocked food shelves, library and guitar propped against the wall. We almost expect the original inhabitants to clatter through the door after a day of research in the field. During all this, the kayakers even found the time to embark upon thorough exploration of the area while also managing a tour of the station. Then, it was back to the ship for the usual excellent and restorative lunch followed by a very short rest. Soon enough, however, it was time to once again board our trusty zodiacs for the afternoon’s objective, the Yalour Islands. These small rocky islands are just across the Penola Strait from the Argentine Islands, tucked in close to the actual Peninsula. Ideal for a landing, zodiac cruising and kayaking. Whilst the kayakers went off for a great paddle, half the remaining group zodiac cruised as the rest of our number went ashore for great viewings of adelie penguin colonies. Here, the penguin chicks were approaching their full size and frantically chasing their parents around in order to get a feed of partially digested krill. This exercise, in addition to losing their fluffy chick feathers, would help them prepare for taking the plunge into the ocean, and adult life, in just a very few short weeks. Adding to the excitement were the ever-present skuas angling to snatch a chick to a premature end. If hectic penguin life was not enough, there were a number of fur seals scattered around, observing the scene through half-closed eyes. Oh, but then there was the scene itself! A backdrop of scattered icebergs, glacier faces and the odd view of a granite peak through gaps in the cloud. In the zodiacs there were other things to entrance a visitor: a massive iceberg arch through which the sea swell surged, humpback and minke whales, penguins in the water and on ice, weddel and crabeater seals on ice floes and even a curious leopard seal that followed the zodiacs back to the ship. All of which added up to a complete day in Antarctica, though the activity wasn’t over yet! After our evening recap, the action moved aft on deck 5 where we had our voyage barbeque and deck party featuring mouth-watering food, mulled wine, and music. The dancing was well under way when the cry “orcas” was heard for the first time. For the next long while, we were able to watch as a group of ‘Gerlach Type B’ orcas hunted a minke whale (successfully? we don’t know) and chased penguins. There was a very large male with a distinctive staggering dorsal fin - a familiar sight in these waters. So, then it ended, a fabulous day in Antarctica… a land that never disappoints! Day 6: Stony Point & Ships Cruise Positie: 64°54’.2 S 062°55’.1 W In Antarctica, even the best planned itinerary just doesn’t go as expected. Soon after we woke up on our third day of excursions in Antarctica, we learned that our original plan of going to Waterboat Point and Gonzales Vidal Station wouldn’t go ahead due to rapidly changing and challenging weather conditions. Luckily, Expedition Leader Adam and his team had alternative activities in store for us. Instead of heading to Waterboat Point, we opted to make a landing at Sony Point, located in the heart of scenic Paradise Harbour. Here, we were given the opportunity to make a continental landing on the actual continent of Antarctica and we even got to cruise around in glassy calm waters and experience some magnificent wildlife in the bay. On land there was a possibility of taking a walk up to a viewpoint and along the way, we could see some very cute Weddell seals snoozing in the snow. On the water we also had lots of entertainment as we meandered through brash ice on calm waters and no winds, making it a very enjoyable moment to be on the zodiacs experiencing Antarctica at its best. There were even some leopard seals were around checking the visitors in their home and, if that wasn’t enough, there were feeding whales close to the Argentinean station “Almirante Brown. The morning wasn’t finished, yet, however, as our hotel department had a surprise in store for us all. Hotel Manager DJ, Assistant Hotel Manager Rafa and Maitre’d Davor were wondering around on a zodiac with hot chocolate and whisky to keep us warm and happy while having one of the best mornings of our life. Unfortunately for the afternoon we were not lucky enough to do landing or cruising due to the strong winds that went up to 57 knots, but of course the experienced team had a backup plan at the ready to fill the time before dinner, but guess what? A group of excitable humpback whales gave us a fantastic breaching show for over 20 minutes, and everybody had a good time in the outer decks taking amazing pictures. Later on, Pippa gave a lecture about orcas so we could learn and understand more about them as they showed up before bedtime on the BBQ day. Day 7: Whaler’s Bay, Deception Island Positie: 62059’.2 S, 60033’.2W We awoke on our final day of landings as Hondius approached Deception Island – the caldera of a live volcano into which we can sail. The volcano itself erupted some 4000 years ago; an explosive eruption, causing the volcano to collapse in on itself and form the water-filled caldera we see today. These days, to gain access to our morning’s landing site, we sail through the entrance of Deception Island, known as Neptune’s Bellows – an impressive sight to see as the volcanic rock towers above the ship on either side – the gateway to the bay within; Port Foster. Inside the caldera, we land at a site called Whalers’ Bay, a place steeped in history. Originally known as Hektors Whaling station, Whaler’s Bay is where thousands of whales were processed for their blubber. Large boilers and oil tanks still remain; rusting and decaying, yet leaving a lasting reminder of the history of this iconic Antarctic locale. The site was later used as a British Antarctic Survey base, which included a runway, where the first flights over Antarctica began their adventures. Here, you can still see the remains of the accommodation buildings and the aircraft hangar. In the morning, we landed on a black ash and sand beach, where we were greeted with the sight of steam rising from the beach, and the smell of sulphur - indications that we’re now inside an active volcano. We walked amongst the old remains of the whaling station and research base; and imagine what it must’ve been like for the whalers that lived here. Indeed, the morning’s overcast weather was the perfect match for the sombre feeling of this place. We also walked up along the bay and up to a viewpoint known as Neptune’s Window; a small gap in the crater wall looking out towards the Bransfield Strait and south to the Antarctic Peninsula. From here, we have fantastic views over Port Foster on one side, and out to the open ocean on the other, where we spotted some whales surfacing. While half of us are on shore here, the other half go on a zodiac cruise; where the zodiacs cruised through Neptune’s Bellows, past towering rock stacks, and past the chinstrap penguin colony found to the south of the Bellows. By mid-morning however, it was clear that the weather had other plans in store for us. Around the time we were meant to swap activities, the wind increased to a level which meant we had to cancel the landing and head back to Hondius. On the bumpy ride from the landing to the ship, however, everyone got quite wet in the zodiacs, giving us a taste of true Antarctic conditions for our last landing on the White Continent. By the time the last zodiac was back on board the wind was even gusting up to 45 knots! Once back onboard, everyone was able to warm up again with a warm drink in the lounge before another delicious lunch was served from our fabulous galley and dining room team. During lunch, Hondius sailed north to our afternoon landing site on Livingston Island. Unfortunately, as we got closer, the wind got stronger; reaching speeds of 60 knots, stirring the sea up with a growing swell and breaking waves. Due to these conditions we were unable to proceed with our afternoon activities and our adventures in Antarctica drew to a close. As we were unable to get off the ship, the expedition team scheduled an afternoon of lectures instead. First, Ross gave us a fantastic lecture on the History of Whaling in Antarctica. He talked of the first sealers in the 1700s, followed by the whalers that came south in the early 1900s and began an era of incredible destruction, where over a 90-year period, over 2 million whales were slaughtered for their blubber. The scars of this time still remain, with remains of whaling stations like Whalers’ Bay, and the varying recovery of the whale populations. After the International Whaling Commission Moratorium came into effect in 1986, banning commercial whaling around the world, scientists have monitored the growth of the Southern Ocean whale populations; some bouncing back well, like the humpback whale, and some taking a much longer time, like the blue whale. Later in the afternoon, Laura gave a lecture on the geology of Antarctica and its formation. She told us of continental movements and how the meeting of great tectonic plates shaped the Antarctic continent. As we leave the incredible continent of Antarctica, and head north, we have time reflect on our incredible adventure before settling in for another delicious dinner in the restaurant. What more could you ask for? Positie: 59o51’.3 S 066o52’.8 W Wind: SW 6 Weer: Sunny A cloudy sky greets us as we wake up to our first sea day on the Drake passage, making out way north towards Ushuaia. The sea state has somewhat calmed during the early morning hours, after a night of some “Drake Shake”-like conditions. As always, sea days on the Hondius are filled by an extensive education programme hosted by the expedition team. Following breakfast, an insight of the political aspects of Antarctica was examined in a presentation of the Antarctic Treaty, its history and importance to all activities on the continent. This was followed by a presentation about the history of female adventurers in Antarctica, an often-overlooked aspect of Antarctic history, shadowed by the accounts of the male-dominated expeditions of the Heroic Age of Antarctic Expeditions. With relatively calm seas, the dining room at lunch time filled up quickly and previous seasick nausea seemed to given way for healthy appetites once again. With the full schedule of landings and zodiac cruises while at the Antarctic Peninsula, sea days are often a great time for reflection, contemplation processing of both emotional experiences and photographs. Many guests took the opportunity in the afternoon to process and share their photographs on the ship’s computers and to discuss their experiences together in the ship lounge. In addition to this, the expedition team’s educational program continued in the afternoon, where guests were invited to learn more about cloud observation and weather forecasting, giving an opportunity to relate what has been observed during our journey to more theoretical concepts. With a quick break in the programme so we could return all the boots that that kept us warm and dry during the wet Antarctic landings, by late afternoon, following on from the weather observation and forecasting lecture, the important and highly relevant topic of climate change was addressed in form of a factual based lecture followed by an opening up of the floor for questions and discussion. The theme of educational programming followed into the daily recap, where we learned more about about the next day’s plan from our expedition leader Adam, and even got the opportunity was given to learn more about navigation. Additionally, we were given a sneak peak of the acoustics workshop work that Morgan and Sara carried out throughout the voyage. To wrap up the day, we enjoyed dinner in the dining room, along with a buzz of energy and laughter, the sharing of experiences, memories, and formation of new friendships. As per usual after dinner, many of us enjoyed a social drink in the lounge and even watched a beautiful slide show of the kayaking programme to cap off the evening. With the sun once again setting in the horizon, it was time to retreat to the comforts of our cabins, reflect on another beautiful day on board and drift off to sleep before the forecasted overnight storm made for another sporty night in the infamous Drake Passage. Day 9: Drake Passage Positie: 56°06’.7S, 065°17’.8 W Wind: W10 We woke up for our last day in the Drake Passage, rocking steadily in the sea, thanks to the 4 to 5 meters swell around us. The wind was blowing unabated across the open ocean and most of the outer decks were closed for our safety. We knew we were getting closer to the tip of Patagonia when we started seeing albatrosses again. The usual black-browed albatrosses were flying effortlessly around the ship, using the strong winds to keep them afloat. After another amazing breakfast in the dining room, we all gathered in the lounge to see some of the bigger waves around us slamming against the bow of the ship. Alternatively, some of us chose to either cosy up with a book in the lounge or take the time to have a chat with our fellow passengers. Some of our number took the conservative route, however, and decided to go straight back to our cabins to ward off any lingering feelings of sea sickness. At 9:30 am, we were called in the lecture room for the first lecture of the day. Marcel and Ross gave us some interesting information about the environmental impact of cruising ships and took us on a the behind-the-scenes tour of Hondius. Soon after this lecture, our favourite acousticians, Morgan and Sara, showed us the sounds and data they gathered during our adventure and compared this information with the videos they took at the penguin colonies. Just like the previous nine days of our voyage, many of us felt that the morning flew by and, before we knew it, we were called down for our last buffet lunch by our beloved hotel manager, DJ. Thankfully, by this point, the seas had calmed and we could enjoy the delicious meal prepared by our galley team. After our usual 1:00 to 2:00 pm nap, we all went back to the lecture room to listen to Adam talk about the other adventure options that Oceanwide offers for polar travellers. After an amazing trip down to Antarctica, some of us were dreaming of visiting the other side of the world: the Arctic. Finally, for our last lecture of the voyage, Ben introduced the history of the Beagle Channel, especially the native peoples that living along the coastlines of Tierra del Fuego long before the arrival of European sailors in the 1500s. The history of these populations is fascinating and Ben’s lecture helped us realized how the culture and people of Patagonia are inextricably linked to the places we travel through today. At that time, we were slowly making our way into the entrance of the channel, where more stunning seabirds welcomed us to the Beagle’s safe waters. Like all good things, however, our trip can’t last forever. By the early evening, our voyage was officially drawing to a close when we got called to the lounge for our last recap. We shared a glass of Prosecco and cheered with the captain to a wonderful voyage, before we sat back to enjoy the voyage slideshow, thanks to the talents of both Massimo and Myriam. Finally, we enjoyed another dinner and the dining room was buzzing with conversation, sharing memories of the past few days. Before going to bed, we finally saw the first light of the civilization. It was such an emotional journey and a perfect way to end this voyage. Day 10: Disembarkation, Ushuaia Wind: W3 Weer: Partly Cloudy During the late hours of the previous evening, the M/V Hondius pulled into its berth in Ushuaia. Some of our number took the opportunity to venture out into the bustling city streets of Ushuaia for a drink or simply to stretch our legs, while others busied themselves with packing and preparing to disembark from the ship that became our home over the last ten days. By the early morning, however, it was time to get ready to leave our adventures behind. With our bags packed and left out in the hallway, we headed down to the restaurant one last time for yet another scrumptious breakfast. After breakfast, we gathered up our hand luggage, and awaited the announcements that called us down to the pier to disembark. Once on the pier, we picked out our luggage, boarded our buses and taxis and waved a fond farewell to the Hondius and her crew. As we made our way to the airport, or simply into town for an extended stay in Tierra del Fuego, we bring with us the endless memories of time well-spent in Antarctica, while silently planning our next trip to the Arctic or elsewhere in the polar regions. Thank you all for such a wonderful voyage, for your company, good humour, and enthusiasm. We hope to see you again in the future, wherever that might be! Total distance sailed on our voyage: 1572.11 nautical miles Furthest South: 65°13’,711S On behalf of Oceanwide Expeditions, Captain Remmert Jan Koster, Expedition Leader Adam Turner, Hotel Manager DJ Nikolic, and all the crew and staff, it has been a pleasure travelling with you. Reiscode: HDS30-20 Reisdatum: 15 feb. - 24 feb., 2020 Duur: 9 nachten Schip: m/v Hondius Inscheping: Ushuaia Ontscheping: Ushuaia HDS30-20, trip log Op deze reis geweest? Review inzenden Blog inzenden Aboard m/v Hondius Hondius is het eerste geregistreerde Polar Class 6-schip ter wereld dat voldoet aan de nieuwste en hoogste Lloyd's Register-normen voor ijsversterkte cruiseschepen. More about the m/v Hondius »	cc/2021-04/en_middle_0036.json.gz/line1028
__label__cc	0.654759	0.345241	Mar> What These 4 Common Relationship Fights Really Mean — And How To Deal With Them Post published:9th Mar 2020 Post category:Friends / Get Inspired / Life / Lifestyle / Love & Relationships All couples fight. It’s completely natural, and comes with the territory of being in a relationship. But when you find yourself bickering more than usual, it’s natural to wonder, “How much fighting is too much?” and “Are we totally screwed?” Our argument is probably about more than you think. Long-term committed relationships are hard. There are massive benefits to them, of course, but it’s challenging to live with someone day in, day out. You’ve got to cooperate, negotiate, communicate, and connect every single day (if you want to keep the relationship thriving). Add kids to the mix and things get even more interesting. It turns out, there’s often a fight beneath the fight. And lots of couples end up arguing about the same things (I’m far from the only person to squabble with her partner about the dishes). Relationship therapists like Darcy Sterling, Ph.D., LCSW, psychotherapist Vanessa Marin, and Rosara Torrisi, Ph.D., have helped plenty of couples work through their disagreements. And they constantly see common fights boil down into similar root issues that have similar solutions. 1. “You’re always working. I never see you.” Whether you’ve been in a relationship for a few years or a few months, it can be difficult to fit everything into your busy days — and sometimes your relationship takes a backseat. Maybe one person is trying to build a high-powered career and needs to put in extra hours at the office. Or maybe it’s a new-ish relationship and one of you is trying hard to avoid sacrificing your friendships. “Why are you always out with your friends?” is another version of this fight Sterling often hears. The general “spend more time with me” request can mean a few things, Torrisi says. It could be that your partner doesn’t feel like a priority in your life, or it could be that their expectations for being in a relationship aren’t being met. For example, if your partner thought that being with you meant they’d never have to go to family gatherings alone, and now you’re missing events because of work or plans with other people, then you’re not living up to their ideal version of a partner. In either case, Torrisi suggests sitting down together and figuring out your expectations for time spent together. If your partner is insecure about being alone at parties or family dinners, try your best to work your schedule so you can make those events. If they don’t feel like a priority, make the time you can spend together into quality time. “Most people don’t have endless amounts of time, especially people who are just beginning relationships and are often also trying to build a career,” Torrisi says. Maybe you truly only have a few hours every Friday to be in a relationship, but if that’s the case you need to spend those few hours being fully present with your partner. Put your electronics away, plan a date night, try new things together (both in and out of the bedroom), and talk about your relationship. 2. “Can you not be on your phone all the time?” Having technology at our fingertips can be both a blessing and a curse to our relationships. On the one hand, there are dating apps that let us connect with people we never would have met. But then, once we’re in a relationship, the phone can become a distraction, Torrisi says. “What happens with phones is that they’re our primary soothing activity for anxiety and boredom,” she explains. That means that we gravitate toward our phones when there’s an awkward pause in conversation (which tends to happen often when a relationship is young) or when we’re bored sitting at home with a long-term partner. Zack B., 27, constantly argues with his wife about spending too much time on his phone. His head is down so often that she accuses him of being addicted to technology. Typically, he laughs her comments off without addressing them. Yet, couples who tend to have this fight are usually fighting about intimacy more than they are about phone usage, Sterling says. They just might not recognize that. It’s likely that Zack’s wife isn’t really concerned about how many YouTube videos he watches every day. She’s probably more upset that he’s stopped being as engaged with her as he was before the phone caught his attention. The solution to this one is pretty simple: Put your phone away. “There are so many ways we can be more mindful about our phone habits,” Marin says. “I recommend that couples try to spend at least 20 minutes of cell phone-free time per day and have dedicated phone-free date nights.” While you can’t expect to magically spend less time with Candy Crush and more with your partner overnight, you can make it clear to them that you’re trying. That way, the argument might be softer next time, because your partner can gently remind you of what you agreed upon. 3. “Why does your ex like everything you post?” It’s not too difficult to understand the emotion behind this argument: jealousy. And it’s not always about an ex. Jealousy can rear its head when one partner thinks the other is flirting with someone else and even when a partner’s celebrity crush comes up in conversation. Matt, 20, had this problem with his ex-girlfriend. She had what he calls “a flirty personality,” and it bothered him when he saw her interacting with other men, even though he knew her flirting was harmless. Tina, 23, also finds herself feeling jealous a lot, often when her boyfriend talks about his love for Emma Watson, an actress who looks nothing like her. If she’s his biggest fantasy, Tina thinks, then does that mean he’s not really attracted to her? Insecurity is often at the root of jealousy — we get jealous because we worry that our partners aren’t invested in us anymore, or that we’re no longer “good enough” to satisfy their desires. “At its root, [jealousy is] a fear of loss: loss of a person, a situation, or of face. Until you’ve eradicated these issues in yourself, remind yourself that your jealousy has far less to do with what your partner is doing and is more deeply rooted in your own issues,” Sterling writes on her blog. Recognizing that your jealousy is about you, not your partner, can give you the perspective you need to start dealing with the insecurities that are making you feel vulnerable. 4. “Why don’t we have sex anymore?” Anyone who’s been in a relationship long enough for sex to fade has probably uttered these words. But if you’re constantly upset about the amount of sex you’re not having, there may be a mismatch in the way you and your partner express intimacy. Sarah, 25, has a much higher sex drive than her girlfriend. When the two don’t have sex as often as she likes, she admits that she eventually gets so frustrated that she gives her girlfriend the cold shoulder. Again, the solution lies in communication and, specifically, in how we communicate. Usually, fights like this happen because each partner shows love in different ways, according to Gary Chapman, Ph.D.’s book “The 5 Love Languages.” For people like Sarah, sex is more than just a way to feel good physically. Her love language is physical touch, which means that kisses, caresses, and sex are how she shows her partners that she loves them and how she feels loved in return. Sarah’s partner likely shows love in a different way (the other four love languages are: acts of service, gifts, words of affirmation, and quality time). When each person values different parts of their relationship, it can cause tension. The solution: Talk to your partner and figure out what each of your love languages are. In Sarah’s case, she could tell her girlfriend that sex makes her feel loved. It might not result in the bustling sex life she wants — because no one should pressure anyone else into having sex when they’re not in the mood. But, being honest about her feelings could help her girlfriend recognize why sex is so important. It might lead to more sexy nights or the kisses and caresses that Sarah also values. When you find yourself fighting, don’t worry too much. Often, people run scared when they start fighting with their partners, Sterling says. “We think conflict is the sign of a bad match. So instead of building those [conflict-solving] muscles and learning how to resolve it, most people jump ship.” Really, though, arguing is a normal part of every relationship, including non-romantic ones. And Sterling worries more when couples don’t fight than when they do — it’s usually a sign that either or both partners don’t trust that they can get through an argument. “They’re not being authentically themselves,” she says. “They’re walking on eggshells, whether they realize it or not.” Clearly though, we need to be able to express our feelings in order to resolve them. 10 Things Every Long-Term Couple Will Fight About at Some Point The fact is, your personal and professional life, as much as you’d like to be totally separate, are inextricably linked. When things are going well at work but badly at home, it can be a problem–and vice versa. It’s best, therefore, to be aware of common roadblocks in the romantic sphere. Here are the 10 most common fights long-term couples will have: 1. What do we spend the money on? Study after study shows that the two biggest things couples fight about are money and sex. Does the kitchen really need to be renovated (again)? Are we going to send the kids to public school, or a $15,000/year private school? Did you really need to buy another scarf? What you want to spend money on (and when) reveals critical things about your values and priorities. The most common couple pairing is for someone who likes to save, to be with someone who wants to spend. Savers and spenders tend to attract one another … then fight about it. 2. How often do we have sex? Couples therapists call it “desire discrepancy” when one person wants sex more often than the other in a relationship. It’s a common issue in marriages and long-term partnerships. At the extreme, it can become a sexless marriage (see the excellent TEDx talk The Sex-Starved Marriage). Fortunately, therapists say most couples’ actual desire discrepancy is small; partners just think it’s massive. For example, when asked separately, “How often would you ideally have sex per week?” a wife might say, 2-3 times, while her husband says 3-4 times. They only differ by 1-2 times per week, but when asked, “How often would your partner want sex?” the wife in that example will say, “If he had it his way, we’d do it all the time–three times a day!” while he says, “If it were up to her, never! Maybe once a month, maybe.” The perceived differential is far bigger than the actual one. 3. Where are we spending Thanksgiving? (Do we have to go to your parents’ again?) The role of family members and extended family in a relationship is critical … and tricky. Holidays are extra hard because where you spend which one impacts a lot of people–the two of you but also your parents, grandparents, etc. Where the holidays are spent also brings up general boundaries around family (and the accompanying disagreements). This includes questions like, “When they come to town, how long do they stay?” “Where do they stay (do they stay with us)?” and, “How much time do we spend with them?” 4. Were you just flirting with her? Jealousy. If you’re both truly into one another, it’s inevitable that it will come up in some form or another. This fight can also look like, “Why are you still friends with your ex on Facebook?” (That one is always fun.) 5. Who’s doing the dishes? Sharing household responsibilities is a common source of stress, especially if things aren’t clear. Who takes out the trash? Who’s in charge of the finances? Who deals with household stuff like calling to set up the plumber (and who’ll stay home from work to meet him)? Sex therapist Vanessa Marin says that when it comes to chores, “One person almost always feels like they’re carrying more of the load than the other.” The best way to deal is to have an explicit conversation about household responsibilities as soon as you move in together. Agree to be responsible for certain things and see how it goes. If it’s not working, have another talk. Be proactive and don’t be afraid to get into the details (i.e. does taking out the trash include putting in a new bag?). 6. Why do you have to [drink] so much? Or smoke, or play video games, or watch Netflix, or fill in the blank with any other behavior that impacts you and the relationship. Everyone in a serious relationship ends up wishing their significant other would either do something, or stop doing something. 7. Are you mad at me? (Are we OK?) How you deal with anger is something you usually learn from your family of origin. Whether you tend to be passive aggressive, clear and straightforward, or aggressive and defensive, you have an anger pattern and so does your partner. Knowing how to talk about your upset, then have a repair conversation, is arguably the most critical relationship skill you can have. One study even showed that couples who were able to be openly angry in the beginning of their relationship were happier long-term. 8. When are you going to get another job? Losing or quitting a job is stressful. And it’s highly likely to happen to either one or both of you at some point during your relationship. When one partner loses a job, there’s a fine line for the other partner to walk between being supportive and being encouraging. You want to be understanding, but there may also be financial concerns that need addressing. 9. Why are you still working? (Why aren’t you spending more time with me) Once your partner has a job, then you’ve got to negotiate how much time the two of you spend together. Fast Company’s article nails it: “What To Do When Your Crazy-Long Hours Are Ruining Your Relationship.” It starts off with a few common refrains: “So I take it you won’t be home for dinner again tonight?” “Didn’t you have to go into the office last weekend, too?” “Gotta say I don’t feel like I’m much of a priority lately.” How much your partner works can impact your sense of your importance in their life. The underlying issue in this fight is almost always, “Do I matter to you?” 10. What are you doing on your phone? Technology. Social media. Distracted thinking. These are the consequences of a constantly-connected world, and it impacts couples in an intimate way. It can be painful to feel ignored, which is a common feeling when your partner is on his or her phone while you’re together. Some couples institute rules to combat this and protect couple-time (no phones at the dinner table; no phones after 9pm; no being on your phone when we’re having a conversation in the car, etc). Smart. Because it’s natural to have disagreements in a relationship, it can be hard to know whether your level of fighting is healthy or unhealthy. Sex therapist Marin does offers some practical guidance: “If it feels like you guys are fighting more often than not fighting, and that you guys are fighting dirty, you’re probably not a good fit. If you fight every once in awhile and do it relatively skillfully, you’re probably fine!” It’s also worth nothing that if you think you as a couple need a little help or guidance, it’s worth investing in a couples counselor. In fact, it could be the best investment you ever make. If you believe in our mission, please, support us (click here). If you died today, are you absolutely certain that you would go to heaven? You can be! Click here and RECEIVE JESUS NOW Still around 29 million people don’t know that they can get up to 600 EUR for a disrupted flight. As a result, 5 billion EUR in compensation are left unclaimed every year. Compensair is a leading flight compensation company helping travelers to get up to 600 EUR for a disrupted flight. Click this link to claim your compensation: https://www.compensair.com/?utm_source=ig_officialdivinea Tags: Couple Fights, love and relationship, Relationship Fights Previous Post12 Things You Need To Stop Doing With The People You’re Dating Next Post20 Texts To Send After A Good FaceTime or Zoom Date A strong, intimate relationship comes down to 10 crucial factors Dating someone with anxiety: 15 things you need to know 10 Ways to Get Over a Hurtful Past	cc/2021-04/en_middle_0036.json.gz/line1031
__label__cc	0.547559	0.452441	MMXX - EP Hypa Hypa 2010 – present (11 years) Castrop-Rauxel, Nordrhein-Westfalen, Germany Eskimo Callboy is a six-piece electronicore band from Castrop-Rauxel, Germany formed in 2010. The band consists of vocalist Nico Sallach who is the former lead singer of the band To the Rats and Wolves he replaced longtime lead singer Sebastian "Sushi" Biesler who left the band in early 2020. The rest of the band includes vocalist and keyboardist Kevin Ratajczak, the guitarists Daniel Haniß and Pascal Schillo, bassist Daniel Klossek and drummer David Friedrich. After Daniel, Pascal, Kevin, Daniel and former drummer Michael "Micha" Malitzki already reached some ac… read more Eskimo Callboy is a six-piece electronicore band from Castrop-Rauxel, Germany formed in 2010. The band consists of vocalist Nico Sallach who is the former lead singer of the band To the Rats and Wolves he replaced longtime lead singer Sebastian "Sushi" Biesler who left the band in e… read more Eskimo Callboy is a six-piece electronicore band from Castrop-Rauxel, Germany formed in 2010. The band consists of vocalist Nico Sallach who is the former lead singer of the band To the Rats and Wolves he replaced longtime lead singer Sebastian "Sushi" Biesler who left the band in early 2020. The rest of the band includes vocalist and keyboardist Kevin … read more Wildways To the Rats and Wolves Hate/Love MC Thunder MC Thunder II (Dancing Like a Ninja) Dramaqueen My Own Summer Bury Me in Vegas 29,987 listeners Eskimo Callboy 2010 3 Sep 2010 · 6 tracks 6 Mar 2015 · 13 tracks 2 Jun 2017 · 1 track Wednesday 22 July 2020 1,408 Thursday 23 July 2020 1,444 Saturday 25 July 2020 1,917 Sunday 26 July 2020 1,709 Monday 27 July 2020 2,001 Tuesday 28 July 2020 1,959 Saturday 1 August 2020 1,650 Sunday 2 August 2020 1,382 Monday 3 August 2020 1,707 Tuesday 4 August 2020 1,726 Wednesday 5 August 2020 1,736 Thursday 6 August 2020 1,690 Friday 7 August 2020 1,693 Monday 10 August 2020 1,490 Tuesday 11 August 2020 1,553 Wednesday 12 August 2020 1,529 Thursday 13 August 2020 1,551 Friday 14 August 2020 1,579 Saturday 15 August 2020 1,433 Sunday 16 August 2020 1,266 Tuesday 1 September 2020 1,462 Wednesday 2 September 2020 1,501 Thursday 3 September 2020 1,481 Friday 4 September 2020 1,520 Saturday 5 September 2020 1,289 Sunday 6 September 2020 1,186 Monday 7 September 2020 1,468 Thursday 10 September 2020 2,120 Friday 11 September 2020 3,426 Saturday 12 September 2020 2,342 Sunday 13 September 2020 2,007 Monday 14 September 2020 2,392 Tuesday 15 September 2020 2,270 Wednesday 16 September 2020 2,189 Thursday 1 October 2020 1,613 Friday 2 October 2020 1,708 Saturday 3 October 2020 1,436 Sunday 4 October 2020 1,195 Monday 5 October 2020 1,660 Tuesday 6 October 2020 1,608 Wednesday 7 October 2020 1,566 Saturday 10 October 2020 1,349 Sunday 11 October 2020 1,210 Monday 12 October 2020 1,446 Tuesday 13 October 2020 1,454 Wednesday 14 October 2020 1,500 Friday 16 October 2020 1,461 Thursday 29 October 2020 427 Monday 2 November 2020 1,348 Tuesday 3 November 2020 1,224 Thursday 5 November 2020 1,327 Friday 6 November 2020 1,401 Saturday 7 November 2020 1,142 Sunday 8 November 2020 1,056 Tuesday 10 November 2020 1,366 Wednesday 11 November 2020 1,301 Thursday 12 November 2020 1,409 Friday 13 November 2020 1,338 Saturday 14 November 2020 1,127 Sunday 15 November 2020 991 Wednesday 2 December 2020 1,596 Thursday 3 December 2020 1,567 Friday 4 December 2020 1,418 Saturday 5 December 2020 1,163 Monday 7 December 2020 1,380 Thursday 10 December 2020 1,348 Monday 14 December 2020 1,292 Tuesday 15 December 2020 1,323 Wednesday 16 December 2020 1,300 Friday 25 December 2020 964 Saturday 26 December 2020 907 Sunday 27 December 2020 963 Friday 1 January 2021 883 Saturday 2 January 2021 923 Sunday 3 January 2021 918 Monday 4 January 2021 1,180 Tuesday 5 January 2021 1,183 Wednesday 6 January 2021 1,139 Thursday 7 January 2021 1,143 Friday 8 January 2021 1,190 Sunday 10 January 2021 986 Monday 11 January 2021 1,238 Tuesday 12 January 2021 1,255 Wednesday 13 January 2021 1,256 Thursday 14 January 2021 1,258 Friday 15 January 2021 1,271 Saturday 16 January 2021 1,141 15 upcoming events Apr 3 Impericon Festival 2021 Messe-Allee 1, Leipzig, Germany 5 going · 4 interested Apr 10 Impericon Festival 2021 Zenith, Munich, Germany 1 going · 4 interested Apr 11 Impericon Festival 2021 Turbinenhalle, Oberhausen, Germany 7 going · 6 interested Add image 25 more photos www.eskimocallboy.com Twitter (@eskimocallboy) Facebook (eskimocallboy) One Morning Left	cc/2021-04/en_middle_0036.json.gz/line1038
__label__wiki	0.609931	0.609931	Tony Rominger Tony Rominger on a stage of the 1995 Tour de France GW's Archive Tony Rominger and Kevin Livingston Tony Rominger in the 1992 Tour of Spain mapeitorralbobottles Tony Rominger and Abraham Olano in the 1995 Paris-Nice mapeicold Tony Rominger leads Pedro Delgado in the 1992 Vuelta a España Tony Rominger in the 1995 Giro d’Italia Tony Rominger wins a stage in the 1988 Giro d'Italia Tony Rominger in the 1994 Paris-Nice Tony Rominger in the 1992 Giro di Lombardia	cc/2021-04/en_middle_0036.json.gz/line1042
__label__cc	0.664367	0.335633	Psychological Associates of the Black Hills, LLC PABH Margaret D. Kelsey, Ph.D. Jennifer J. Kozel, Ph.D. Trisha T. Miller, Ph.D., Inc. Mark Perrenoud, Ph.D., Inc. Lynette R. Quast, Ph.D. Jennifer J. Kozel received her master’s degree in clinical psychology at Mankato State University in Minnesota, and her doctoral degree in clinical psychology at the University of South Dakota. Dr. Kozel also completed an internship at the Kansas City Veterans Affairs Medical Center, and a postdoctoral fellowship in neuropsychology at the University of Kansas Medical Center. Currently, Dr. Kozel enjoys doing psychotherapy with adults, adolescents, and children. She specializes in depression, anxiety, attention deficits, and interpersonal problems. In addition, Dr. Kozel administers psychological evaluations, specializing in evaluations of personality, emotional functioning, learning, memory, and attention/impulsivity. Dr. Kozel offers the following specialized psychotherapy: Attention Deficits Interpersonal Problems Dr. Kozel administers the following evaluations: Personality Emotional Functioning Learning Memory Specialty of Dr. Kozel When not working, Dr. Kozel spends her leisure time engaging in family activities, traveling, gardening, sports, and many other outdoor activities. She also enjoys cooking tasty food, hanging out with animals, and watching almost any kind of movie. Adolescents 12 & Older Adults & Couples Appointments with Jennifer can be arranged by calling Psychological Associates at (605) 348-6500. If you are a new patient inquiring about making a first appointment, please click on the Request Services button above. Upon receiving your request we will reply to you with a phone call. Thank you. Please do not email or use the form below to schedule an appointment. Rapid City Office 1818 W Fulton Street Suite 201 Rapid City SD 57702 Email: officemanager@rushmore.com Custer Office (Dr. Perrenoud only) 1369 Montgomery Street, Custer, SD 57730 Email/Texting Consent Form Childhood History Form Adult Intake Form Release of Information Form Telehealth Consent Form not all providers require the Childhood History Form or the Adult Intake Form – please inquire with office.* PSYCHOLOGICAL ASSOCIATES OF THE BLACK HILLS \| Rapid City 1818 W Fulton Street Suite 201 Rapid City SD 57702 8am - 5pm & by appointment PSYCHOLOGICAL ASSOCIATES OF THE BLACK HILLS \| Custer Office (Dr. Perrenoud only) DIRECTIONS TO OFFICE DOWNTOWN RAPID CITY LOCATION \| If you are coming from downtown Rapid City: drive west on Main St., turn left on Jackson Blvd., turn left onto W Fulton St. (the very first stop light you come to). Our office building is on the left up the hill. Drive to the TOP of our buildings drive (to the East entrance door). Please do not enter through the South entrance door at the bottom of the drive. How Do We Move Forward After Losing the People We Love?	cc/2021-04/en_middle_0036.json.gz/line1054
__label__cc	0.552051	0.447949	Meet Dan Wyns, the Michigan Tech Transfer Team Agent Michigan State University, Crop Protection Agent I was introduced to honey bees over a decade ago while in New Zealand on a working holiday and have been consumed with caring for and learning about them ever since. Prior to joining BIP I was a commercial beekeeper in New Zealand and western Canada where I was fortunate to gain a diversity of beekeeping experience across a variety of climates and agricultural landscapes. I joined BIP in 2014 as a member of the PNW tech transfer team and spent 3 years working with beekeepers across OR, WA and ID. The addition of a Tech Transfer position in Michigan has allowed me to carry on working with bees and beekeepers while relocating to my home state. I was born in Grand Rapids, raised in Grand Haven, and studied in Ann Arbor so the opportunity serve the beekeeping community here is especially satisfying. My family roots run deep in Michigan horticulture and I look forward to continuing that tradition by working to promote colony health and support local agriculture. Bee Informed Partnership Tech Transfer Team in Michigan In the summer of 2017, the Bee Informed Partnership (BIP) created a new technical transfer team to support beekeepers in MIchigan. The Bee Informed Partnership (BeeInformed.org) is a collaborative nationwide effort between beekeepers and researchers across multiple disciplines to better understand and address the declines in honey bee health. BIP was initially founded in 2011 with support from the United States Department of Agriculture and National Institute of Food and Agriculture and has recently transitioned to a non-profit 501 (c)3 organization. The core mission of BIP is to provide resources to increase colony health and survivorship by providing relevant and timely data to beekeepers allowing them to make better informed management decisions. BIP provides educational resources and information on the importance of honey bees for our food supply and those issues impacting honey bee health to the public and to beekeepers. Through the use of the tech transfer team model BIP is able work directly with commercial beekeepers as well as providing diagnostic and outreach services to all beekeepers. The technical transfer teams provide partnering commercial beekeepers with independent colony health evaluations, colony sampling, pest and pathogen diagnostics, and reporting and analysis of those assessments. The University of Maryland is home to BIP leadership as well as the diagnostic lab, while Tech Transfer individuals and teams are based out of host universities and extension branches within their regions. BIP tech teams are currently working with 109 commercial operations across the country, managing approximately 450,000 colonies which represents about 17% of colonies nationally. We are excited with the current level of support and involvement from the industry and look forward to these numbers growing as Michigan beekeepers join the program. In addition to the technical transfer teams BIP provides emergency response kits (ERKs) to beekeepers of any size to assist in determining and ruling out causes of failing colonies. BIP also manages a national Sentinel Apiary Program where beekeepers can monitor colony weight and health metrics to contribute to a national database relating forage, nectar flows, and diseases. Michigan State University joined the sentinel apiary program in the spring of 2017; follow the progress updates and real-time data on the MSU sentinel apiaries blog. The BIP annual survey includes beekeepers of all sizes and addresses management practices and loss rates and disseminates findings about management practices that are associated with increased survivorship. The latest state and national results for 2016/2017 are available on the BIP website. Be sure to sign up for BIP email alerts to get updates on our latest findings and a reminder to participate in next year’s survey. If you have any general questions about BIP call us at (443) 296-2470, get in contact with us, or send an email to the new Michigan tech transfer agent Dan Wyns at wyns@msu.edu	cc/2021-04/en_middle_0036.json.gz/line1060
__label__cc	0.59151	0.40849	Places Locker app Another 'Shape Up Challenge' complete Read Rachael's challenge Ready to join in at Places Gym Preston? Discover more! Places Gym Preston member completes summer challenge Places Gym member Rachael entered a prize draw earlier this year to win a 12-week Shape Up for Summer programme – and won! Open to all, one winner was chosen from each of the six Places Gyms. Rachael has now completed her 12-week programme, with the help of Places Gym Preston trainer Andy, and feels better than ever. Before starting the programme, Rachael wasn’t a member of a gym and weighed almost 13stone, measuring in at: 41” chest Just like so many of us who may struggle with losing weight and maintaining the result, or who are unsure of what you can do in the gym, the 12-week programme came at the right time for Rachael who wasn’t a member of any gym, but knew she wanted to look and feel different this summer. Rachael says: “Having fluctuated in weight over the years, I was so happy to have won a dedicated 12-week programme for me to not only lose weight and get fit – but to understand the best ways for me to work out in the gym and maintain a healthier body.” Andy worked with Rachael to put together a personal programme they could both agree on. While it is important for individuals to know what they would like to change and therefore the goals to reach, it is important for personal trainers to work towards these goals in safe, smart and fun ways. "Working with Rachael during the Shape Up for Summer challenge has been a great pleasure - she has changed a number of bad habits and routines that have been stopping her making progress in the past. This wasn't easy for Rachael, as she was admittedly doing these out of habit without even thinking about it (chocolate after meals, choosing convenient ready meals) but she turned a corner and has been reaping the rewards of her hard work, new habits and routines!” says Andy. “She has lost 8 lbs without being super strict. Rachael’s still enjoyed a few drinks and meals out with friends and family - but is now feeling more confident in her clothes and fitter in day to day life!” While Rachael gradually lost weight over the course of the 12-week programme, it was more intense than she initially thought. “It isn’t easy starting new exercises and having a trainer push you – you realise how much slack you give yourself when training on your own. But, Andy encouraged me to keep going and I’m ever so glad he did – I feel so much better within myself, I have more energy now!” Rachael’s new weight is 12stone 2pounds – an incredible change. But what’s more impressive is the physical changes to her body, dropping 2” from her chest, 3.5” from her waist and 3.5” from her hips. “When you only have a few pounds or a couple of stone to lose, people don’t realise it can actually be harder. Your body isn’t as shocked as it would be if you were a heavier weight trying to lose over 5 stone for example. It can be a slow progress which sometimes make it difficult for people to find the motivation to continue, but when the results come through you find that push you needed,” explains Andy. “It was very much this way for Rachael. Seeing the difference in confidence in Rachael is why I love my coaching and I hope that she continues to keep working hard and reaches her goals in the future.” Have you started working on your fitness journey yet? Speak with our team of personal trainers if you’re looking for some advice on how you can level up and really make a difference to your training. Perhaps you aren’t a member of a gym yet and are unsure whether it is for you – why not try one of our gyms? Register for a free 5-day pass at your local gym and see where your journey takes you. Join in with the latest discounts Find out what deals are available with Places Gym With over 40 classes per week, find out what's right for you! Try us, Love us Register fora FREE 5-day pass at your local gym & find out why our gyms are the Place to be Places Gym Our full privacy policy Refer a friend & enjoy a free month! icon--twitter icon--facebook icon--instagram To receive all the latest offers and promotions from Places Gym, please add your email address below to join our mailing list. Places For People Leisure Ltd 2017 © All Rights Reserved. Site by Ahoy JavaScript is disabled. While you may be able to browse the website some elements may be unusable	cc/2021-04/en_middle_0036.json.gz/line1062
__label__wiki	0.690159	0.690159	News Feeds By Subject News Feeds By Companies About PRWire Release from DeMorgan Ltd ACCELERATING THE SOUTHERN HEMISPHERE THE DEMORGAN LTD GROUP OF COMPANIES TO RECEIVE UP TO $54 MILLION FROM AUSINDUSTRY R&D TAX REBATE SCHEME About DeMorgan Ltd Interconnected Research remains the sole RSP dedicated to Bitcoin research Interconnected Research is pleased to advise that the company has satisfied the requisite criteria under AusIndustry’s R&D Tax Incentive Scheme to remain registered as a Research Service Provider (RSP). An RSP is an organisation that is registered under section 29A of the Industry Research and Development Act 1986 as a RSP by Innovation Australia has appropriate scientific or technical expertise and resources to perform research and development on behalf of other companies. ICR is the only privately owned company registered by a government body as a research provider specialised in Bitcoin and cryptocurrency research. We help to ensure that the companies we work with meet the guidelines from the Australian Taxation Office (ATO) on beneficiary of activities to ensure that the activities that they contract to complete satisfy the requirements of research that would allow them to claim a rebate of up to 43.5 cents in the dollar through the R&D Tax Incentive program. This allows companies to have access to skills and systems that can help drive the uptake of Blockchain based businesses in Australia. In addition, we provide companies access to some of the most powerful supercomputers in the world. Two of these systems are listed in the Top 500 HPC list. We remain the world’s only government endorsed Bitcoin incubator and research services provider. Managing Director and CEO: DR. Craig Wright P 0417 683 914 info@demorgan.com.au Media/IR: Ms Ramona Watts P 0423 912 994 About Interconnected Research Interconnected Research (Inconn.ec) is a research and development organisation focused on cryptocurrencies. We understand cryptocurrency, the underlying technology and the possibilities this technology can provide for the future. We offer guidance on cryptocurrency related products, the protection of intellectual property, provide assistance with patenting and commercialisation of start-up companies. We encourage start-ups and entrepreneurs to contact us to explore the range of investment and partnership opportunities, available in the focus areas of virtual currency and science and information technology. We are the first AusIndustry authorised RSP dedicated to Bitcoin. A Research Service Provider (RSP) is an organisation that is registered under section 29A of the Industry Research and Development Act 1986 as a RSP by Innovation Australia has appropriate scientific or technical expertise and resources to perform research and development on behalf of other companies. ICR is a member of the DeMorgan Ltd group of companies. terms of use \| about us \| contact	cc/2021-04/en_middle_0036.json.gz/line1068
__label__wiki	0.681135	0.681135	Release from Markson Sparks! "I'm Done, Get Me Out Of Here" announced about 1 year $500 MILLION DOLLAR CHINESE COMPANY ENTERS AUSTRALIAN FIGHT GAME ! $5m SUPERYACHT "THE SEVEN STAR" MAKES SYDNEY HARBOUR HOME! About Markson Sparks! INTERVIEW TONY DOHERTY AS HE AND ARNOLD SCHWARZENEGGER WELCOME TWINS TO THE WORLD! NEW ARNOLD CLASSIC ASIA ANNOUNCED FOR IMMEDIATE RELEASE December 6, 2015 ARNOLD SCHWARZENEGGER AND HIS AUSTRALIAN PARTNER TONY DOHERTY WELCOME TWINS TO THE WORLD! Arnold Schwarzenegger and Australia’s Tony Doherty gave birth to the Arnold Classic Australia earlier this year and now they are pleased to announce the birth of twins in 2016 with the Arnold Classic Australia returning to Melbourne from March 18 to 20 2016 and a new baby twin, the first-annual Arnold Classic Asia to be held in Hong Kong from August 19-21 2016, creating the largest series of multi-sport festivals in the world including the Arnold Classics in Columbus, Ohio USA, Rio Brazil, Madrid Spain and Johannesburg South Africa. As with the Arnold Classic Australia which attracted over 60,000 guests to the Melbourne Convention and Exhibition Centre, the Arnold Classic Asia includes the Arnold Classic men’s professional bodybuilding contest, an amateur bodybuilding contest, a large health & fitness EXPO and select amateur sports competitions and demonstrations. “ I’m so excited and proud to be expanding my relationship with Arnold into Asia. The Arnold Classic Australia was a tremendous success this year . It’ll be even bigger in 2016 and now with the addition of Asia it really is a tremendous export opportunity for the Australian sports, fitness and health industries to make connections and do business with China. Arnold Schwarzenegger has a vision to help make the world a fitter and healthier place . We can join him on his journey and help Australian businesses at the same time and with every continent now covered, this makes the Arnold Classic the world's biggest multi-sport festival." says Melbourne's Tony Doherty. TO INTERVIEW TONY DOHERTY email max@marksonsparks.com or call Max Markson on 0412501601 “The Arnold Sports Festival is proud to continue its world-wide growth with the presentation of Arnold Classic Asia in Hong Kong in 2016,” said Jim Lorimer, who co-founded the Arnold Classic with Gov. Arnold Schwarzenegger in Columbus, Ohio USA in 1989. “The addition of Arnold Classic Asia will put the Arnold Classic on six continents in 2016 and will be the latest step in Arnold’s world-wide fitness crusade.” The Arnold Classic Asia is a partnership between Classic Productions, Inc., Tony Doherty, promoter of Arnold Classic Australia, and Hong Kong businessman Richard Petty. The first Arnold Classic was held in Columbus, Ohio in 1989 and featured professional men’s and women’s bodybuilding. That event, now known as the Arnold Sports Festival, now features more than 18,000 athletes competing in more than 50 sports and events and draws 200,000 attendees from more than 80 nations. The Arnold Classic first expanded in 2011 with the creation of Arnold Classic Europe, held each year in Madrid, Spain. Arnold Classic Brazil debuted in Rio de Janeiro in 2013 and the first Arnold Classic Australia was held in Melbourne in March 2015. Arnold Classic South Africa in Johannesburg will be held for the first time in May 2016. TO INTERVIEW TONY DOHERTY email max@marksonsparks.com or call Max on 0412501601 For more on the Arnold Classic Australia visit www.arnoldclassic.com.au Max Markson MARTINA NAVRATILOVA IN AUSTRALIA JANUARY 18-31 2016 MELBOURNE MARCH 18-20 2016 www.arnoldclassic.com.au Markson Sparks! 410 Elizabeth St E: max@marksonsparks.com Work: +61 2 9213 2900 www.marksonsparks.com	cc/2021-04/en_middle_0036.json.gz/line1069
__label__cc	0.518094	0.481906	Home Node Advanced Search Advanced Search Advanced Search Article Bulletin (37) Apply Article Bulletin filter Advanced Page (4) Apply Advanced Page filter Article Meteoworld (2) Apply Article Meteoworld filter Events of Interest (2) Apply Events of Interest filter WMO Programmes (2) Apply WMO Programmes filter 55 contents match your search. 20544650778_33ba32a89d_z.jpg Applications, Data exchange, Technology transfer, Environment, Natural hazards, Observations, Oceans Within its mandate in the areas of weather, climate and water, WMO focuses on many different aspects and issues from observations, information exchange and research to weather forecasts and early warnings, from capacity development and monitoring of greenhouse gases to application services and much, much more. 15998587205_b38dfbc9e8_z-2.jpg Global Data-processing and Forecasting System GDPFS WMO Programmes Weather, Data exchange The GDPFS is an international mechanism that coordinates Member capacities to prepare and make meteorological analyses and forecast products available to all Members. It enables delivery of harmonized services and is currently organized as a network of Global, Regional and National Centres. bulletin2015_records1.jpg Rescue, Archival and Stewardship of Weather Records and Data Weather, Information, Data exchange, Oceans, Observations, Research, Partnership, Climate, Climate services, Environment Bulletin nº Vol 64 (1) - 2015 Theme: Observations Publish Date: 2 March 2015 Data repositories and archives play a critical role as the source for the observational data used in the study of weather and climate. After over two centuries of recording observations on paper, observations in the last 20 years have mostly been collected digitally. Creating homogeneous, complete data sets from disparate collections is a fundamental challenge facing the climate research community. bulletin2015_gfcs1.jpg Climate Services – Transitioning from CLIPS to GFCS Weather, Environment, Research, Observations, Information, Data exchange, Climate services, Forecast, Disaster risk reduction Theme: Climate The present Global Framework for Climate Services (GFCS) with a vision “to enable society to better manage the risks and opportunities arising from climate variability and change, through the development and incorporation of science-based climate information and prediction into planning, policy and practice” carries forward and builds on the solid foundation laid by the Climate Information and Prediction Services (CLIPS) project. bulletin2014_satellites1b.jpg Preparing the Use of New Generation Geostationary Meteorological Satellites Weather, Observations, Satellite, Space, Data exchange, Forecast, Environment, Agriculture and food security, Disaster risk reduction, Water, Public health Publish Date: 3 November 2014 Seven new generation geostationary satellites will be launched into positions over the equator within the next five years. These launches will drastically change the Space Component of the WMO Integrated Global Observing System (WIGOS) and National Meteorological and Hydrological Services are challenged to prepare for the advanced capabilities the satellites will offer. The imager capabilities, sampling rate, spectral resolution and spectral channels, of this new generation of satellites will drastically increase data rates – by an order of up to 100. All National Meteorological Hydrological... bulletin2014_quantifying1b.jpg Quantifying Risk Before Disasters Occur: Hazard Information for Probabilistic Risk Assessment Weather, Climate, Disaster risk reduction, Natural hazards, Data exchange, Floods, Agriculture and food security Theme: Disaster risk reduction Risk is a forward looking concept that implies an eventuality of something that can occur. Therefore, assessing risk means looking at the possible events that can occur, quantifying how likely they are to happen and appraising the potential consequences should they occur. bulletin2014_ebook1.jpg E-book Review: Communicating Hydrometric Data Quality: What, How and Why1 Weather, Climate, Water, Data exchange, Environment, Climate services, Agriculture and food security Theme: Water The availability of adequate fresh water for human consumption, agriculture, industries, cooling of industrial and electric generating facilities, and aquatic and riparian resources is critical, or will become so, in all countries. Accurate and verifiable streamflow data are essential for making confident estimates of available fresh water, for designing roads, bridges and other infrastructure, for calibrating and validating hydrological models, and for assessing the potential impact of floods. The quality of that data is ever more important as resources become more limited and water... 62-2-06-users-are-the-winners-as-wmo-information-system-comes-of-age.jpg Users are the Winners as WMO Information System Comes of Age Weather, Climate, Climate services, Information, Observations, Research, Forecast, Data exchange, Satellite, Capacity development Publish Date: 1 October 2013 by Markus Heene \| The past two years have been marked by intensive efforts to complete the WMO Information System (WIS) and make it fully operational. 62_1_index_1.jpg In this issue: The World Weather Watch at 50 Weather, Climate, Climate services, Observations, Satellite, Forecast, Data exchange Weather and climate know no national borders. The transformation of the International Meteorological Organization into the World Meteorological Organization (WMO) in 1950 was an essential response to the need to strengthen global cooperation in this scientific area. In 1960, the Executive Council of WMO established World Meteorological Day to build public awareness of the services provided by National Meteorological Services and WMO. These services involve the observation, collection, processing and dissemination of meteorological, hydrological and other related data and products. The 23rd of... The World Weather Watch at 50 Weather, Climate, Climate services, Observations, Information, Satellite, Data exchange, Forecast, Water, Oceans The World Weather Watch (WWW) is one of the crowning achievements of WMO. The celerity with which WMO responded to the introduction of meteorological satellites with the establishment of the WWW, and its subsequent adoption by all WMO Members, set a standard for international cooperation in operational programmes that remains unequalled today.	cc/2021-04/en_middle_0036.json.gz/line1071
__label__wiki	0.501898	0.501898	Science and Environment Google partners with GlaxoSmithKline on $700 million ‘bioelectronic’ venture News August 3, 2016 No Comments Vicky Google’s parent company is joining hands with GlaxoSmithKline (GLAXF), the leading British pharmaceutical firm, to launch a new venture to develop “bio-electronic medicines,” according to a joint announcement made on Monday. The two companies are supposed to invest as much as $700 million over the next seven years into the new venture, to be called Galvani Bioelectronics. Alphabet’s life sciences division, Verily, will own 45% of the venture. Bioelectronic medicine is a new area of research focused on implanting tiny devices that can alter electrical signals in your nerves to treat chronic conditions like arthritis, asthma and various inflammations. The promise is that these devices could be more effective and less expensive for the patient than existing treatments. Google officially launched a standalone business dedicated to life sciences in August 2015, just days after the company announced the corporate restructuring that created Alphabet. It rebranded as Verily in December. Alphabet previously partnered with Johnson & Johnson (JNJ) to develop better robotic tools for surgeries. Duterte, Philippine President looking ahead with war game with US In Indonesian boat overturned, 20 dead and 39 being saved Ravindra Jadeja, Karun Nair star in India’s record win Global Electric Resistance Welded Pipes Market -Top Company Profiles, Insights, Opportunities, Segmentation and Forecast, 2017 – 2022 vicky Email Author Vicky is a digital marketing executive who specializes in technology. He combines his experience in forthcoming technology research. His intension is to create updated website with all modern technology, and modern devices. Unique New Year Traditions Around the Globe Global Beverage Coolers Market 2020 COVID-19 Updated Analysis By Product (Single Door, Double Door); By Application (Household, Commercial) Global Asphalt Modifier Market 2020 COVID-19 Updated Analysis By Product (Physical Modifiers, Chemical Modifiers, Other); By Application (Paving, Roofing, Other) Fermi Paradox – Existence Of Life On Other Planets Ward Ferry May Invest $20 Million in Treebo 5G to Soon Make an Entry in India Tweets by @patriaarc Category Select Category Business Education Event Health Money News Science and Environment Smartphones Social Media Technology Travel UK Uncategorized World Archives Select Month December 2020 July 2020 May 2019 August 2017 July 2017 June 2017 May 2017 April 2017 March 2017 February 2017 January 2017 December 2016 November 2016 October 2016 September 2016 August 2016 July 2016 June 2016 May 2016 April 2016 January 2016 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 Patriarc Copyright © 2021.	cc/2021-04/en_middle_0036.json.gz/line1086
__label__wiki	0.642905	0.642905	Middle Finger Salute Est. late 2005 aged just 14 and 15 Middle Finger Salute have gone from strength to strength, playing with punk legends such as Stiff Little Fingers, The Buzzcocks, Rancid, and the Misfits to name but a few. The band embarked on their first uk tour in early 2007 as part of the Easter Punk Feast annual tour along side punk rock heroes the Angelic Upstarts and The Vibrators, the band being the youngest ever to be a part of the tour at just 16 and 17. Read more on Last.fm …read full bio Est. late 2005 aged just 14 and 15 Middle Finger Salute have gone from strength to strength, playing with punk legends such as Stiff Little Fingers, The Buzzcocks, Rancid, and the Misfits to name but a few. The band embarked on their first uk tour in early 2007 as part of the Easter Punk Feast annual tour along side punk rock heroes the Angelic Upstarts and The Vibrators, the band being the youngest ever to be a part of the tour at just 16 and 17. The years following the tour Middle Finger Salute became regulars at Rebellion festival in the UK and Europe. As well as this Middle Finger Salute played Germany's best punk festival, Punk and Disorderly in Berlin in 2009. Evolving as a band Middle Finger Salute Gained a place on the East Coast leg of the US Vans Warped Tour 2009 being one of Only a handful of UK bands on the tour along with Gallows and The Blackout. Since then Middle Finger Salute have been back to the United States playing at the world renowned SXSW music industry festival and been invited back on to the Vans Warped for a longer leg in 2010. As well as being fortunate enough to be on the 2009 and 2010 official Warped Tour Compilation CD's. Read more on Last.fm. User-contributed text is available under the Creative Commons By-SA License; additional terms may apply. Sorry, there aren't any upcoming shows for middle finger salute, +add one? warped tour [2013] chiodos allstar weekend motion city soundtrack woe is me forever the sickest kids big d and the kids table the summer set reel big fish anarbor go radio versaemerge letlive goldhouse never shout never rdgldgrn upon a burning body oh sleeper hand like houses beebs and her moneymakers big chocolate crizzly echosmith alvarez kings five knives beware of darkness kairo kingdom emily's army mighty mongo forever came calling run dmt stephan jacobs pacific dub mad child shy kidx strawberry blondes outasight young london craig owens the american scene owen plant matt embree i can make a mess like nobody's business william beckett allison weiss 12pm (doors @ 11am) \| $35//45	cc/2021-04/en_middle_0036.json.gz/line1091
__label__wiki	0.804677	0.804677	Ranclette's Personal Archive Back Table of Content Next Chapter 367: When Night Comes (5) The Dragon half-blood. ‘How many Dragon hearts did that bastard say that he ate?’ His reddish brown eyes sunk down as he looked somewhere. However, Cale's mind was going through his sea of records more than ever before. Cale finally found the record he was looking for. It was something that the Dragon half-blood had said about himself. ‘However, reaching the second growth phase in 900 years was my limit because I was a created being. I ate a total of four Dragon hearts until I reached my second growth phase. If you count the original Dragon's heart within my heart, I was made with the lives of five Dragons.’ The lives of five Dragons and their hearts. Boom. Boom. Boom. Cale lowered his head. He could feel a heart beating louder than usual. It was not his heart but Raon’s. Cale could tell that Raon was anxious and flustered based on how his heart was beating. That was what helped him return to his senses. Pat. Pat. Cale patted Raon's back. He continued to hear the white Dragon’s voice as he did that. “There were two children.” One black egg. And one red egg. “One was very big and gave off a strong presence. He was so strong that he could affect all of the mana around him even while in his egg.” The white Dragon made eye contact with Cale. “It was as if he was born with both of the Dragons’ presences in one.” A faint smile appeared on the white Dragon’s face. "And the other child was small. The size of his egg was smaller than normal too. That egg was very weak.” The white Dragon's short front paws gathered together. It was as if she had something precious on top of her two paws. “I could feel just how small and weak the child inside the egg was.” The atmosphere around the white Dragon who was looking down at her empty paws instantly changed. Squeeze. Choi Han subconsciously placed his hand on his scabbard. The cold presence was giving him a sense of danger. However, the white Dragon continued on as if she did not notice. “I realized something at that moment.” Raon was listening carefully as Cale continued to pat his back. What did the white Dragon, what did this illusion figure out? “Because one child was too weak and one child was too strong… I realized that it would take them both a long time to break out of their eggs and come out into the world.” One child was too weak to be called a Dragon. The other child was even stronger than the Lord when she was young. Regardless of the reason, the only thing she could tell was that both of them would take a very long time to hatch. “I only had about two hundred years left of my lifespan at that point.” Flinch. Raon's body started to shake. Raon clenched his eyes closed even though his face was already buried up against Cale. The white Dragon watched Raon's back with a sad expression on her face. She had to say as much as she could because she did not have much time left. “It would be great if they would be born within 200 years, but I had to prepare for their futures just in case they didn’t.” The white Dragon’s wings started to move. She flew toward Cale. “Until the child could break out of the egg and hatch. I needed a strong spell that would be able to stand a long period of time.” The white Dragon put her front paw on top of Raon's back. She then started to whisper. “I needed to make it so that the children could live happily without lacking anything whenever they hatched.” Raon opened his eyes. He then turned his head. The white Dragon looked young, but her eyes seemed to show traces of her long life. The white Dragon started to smile brightly once she made eye contact with Raon. The white Dragon continued to speak. “That weak and small child is in front of me now.” The black egg. The child who was born extremely weak in comparison to the red egg. The small child she had been worried would disappear without even being able to hatch. Although she was just an illusion, the white Dragon who held all of her memories could not help but smile. It was because she could not cry. She felt it as soon as she saw him. ‘This is my child.’ That was an emotion that even a Dragon could not explain, however, she was certain about it. The white Dragon continued to smile brightly toward the clear dark blue eyes that were looking at her. Raon turned his head back into Cale’s chest. Cale could feel his chest starting to get wet. He heard a calm and low voice ask a question. “…How did your castle end up like this, ma’am?” It was Eruhaben. Cale had never heard Eruhaben speaking respectfully to anyone before. Although he was being respectful, he was still going to ask what was on his mind. The destroyed castle interior. However, the real meaning behind the question was not about the destroyed castle. ‘How did you lose Raon and the red egg?’ The white Dragon who realized the hidden meaning had a peculiar smile on her face. “It was because I trusted too much.” The white Dragon had been close friends or practically family with every generation of the Dragon Slayers. This was a relationship that started with the first Dragon Slayer and continued with the second, fourth, tenth… And the generations after that. “I asked my close friend, the Dragon Slayer of that generation, for a favor before I died. I asked if they could protect this castle generation after generation.” The white Dragon had left this castle in the protection of that generation's Dragon Slayer before she died. Of course, she didn’t mean physically protecting it. Her powers were enough to protect it from external enemies. What the white Dragon needed them to do was maintain the items in the castle just in case the preservation spells did not work properly. She also asked the Dragon Slayer to be close friends with her children, showing them the joy of living together with others. “That Dragon Slayer swore an oath that they would keep that promise generation after generation.” That generation's Dragon Slayer had accepted the request happily without any hesitation. The white Dragon’s front paw pointed toward the white crown in Cale’s hand. "That crown was an item that belonged to the Dragon Slayers. The door to this castle would open if someone had that crown and a different power.” Only someone with both the crown and a different power could come into the castle. “And they kept that promise until 1,000 years ago.” The ancient Dragon, Choi Han, and Ron started to frown. 1,000 years ago. That was right around when the White Star was first born. “The Dragon Slayer from 1,000 years ago broke that oath and the castle ended up like this.” That Dragon Slayer would be the White Star. Someone started to speak at that moment. “Why-” It was Choi Han. Choi Han looked toward Raon in Cale’s arms before asking the White Dragon the rest of the question with a stiff expression. “Why did you let the White Star, that Dragon Slayer, do this?” Choi Han looked toward the White Dragon with a gaze full of sorrow. He was thinking more about the fact that white Dragon might have just sat by and watched the White Star than the fact that she was the Dragon Lord. “You were strong. You were strong enough, so why-” However, he was cut off. The white Dragon's voice echoed in the room. “I, I was a sealed existence until I met my children.” Choi Han could not say anything. The white Dragon started to frown. Choi Han had a thought as he looked at that expression. The white Dragon looked to be the same age as Raon. Seeing that white Dragon's frowning face made him think that Raon would also look like this when he was extremely sad, angry, or full of despair. This was the first time Choi Han had thought that it was good that Raon's face was in Cale's chest. The white Dragon’s voice was calm and cautious unlike her expression. “This illusion is an existence that grows along with the children’s growth speed.” It was created so that the children would not be lonely and have a chance to learn. That was because this illusion had no need to worry about any external dangers. The ‘protection’ of the Lord was that strong. “And only this castle is my territory. I cannot do anything if I leave the castle.” Her eyes and ears were open even though she was sealed. That was how she had seen everything. However, the white Dragon did not tell them what had happened 1,000 years ago. It was because, although she could only see his back, she could tell that the black Dragon was crying. The white Dragon felt as if her heart that had been ripped apart once was ripping apart once again. However, she calmly continued to speak. “My seal was removed once this child appeared in front of the castle.” Raon was the reason the white Dragon could appear in the world in this half-transparent state. “Because I wanted this to be the children’s hometown. That was why I wanted to create a space they could always return to rest even if they left.” The thing that the white Dragon wanted even more than to return to nature with a beautiful death was to let her children know that they had a family and a home to return to whenever they wanted. “That was why the castle gate opened and I appeared now that my child had returned.” The white Dragon then raised her paws that were as small as Raon's and patted Raon’s back. Although Raon probably could not feel it properly because she was half-transparent, the white Dragon continued to pat and caress Raon's back. Choi Han just watched as he did not know what to say. Ron was frowning. He was the only one here who had raised a child. That was why he could tell the meaning behind the white Dragon’s expression as she caressed Raon's back. Nobody could easily break this silence. On and Hong looked up at Raon from next to Cale's feet while Eruhaben and Bud seemed lost in thought. The others were just choosing to be silent. It was at that moment. The silence was broken. “…Even if you trusted someone, how could you allow free entry into the castle when you didn’t know how the future generations would be-” It was Bud. Mercenary King Bud was quietly mumbling with a frustrated expression. He had subconsciously said it because he could not hold back his frustration anymore. He seemed to be blaming the white Dragon, but nobody could blame him for doing that. It was because he looked extremely sad. Someone else chimed in at that moment. “You said that the Dragon Slayer swore an oath.” It was Cale. Raon flinched at his statement and raised his buried head. The others looked toward Cale as well. However, Cale was only looking at the white Dragon. The white Dragon had indeed said that. ‘I asked my close friend, the Dragon Slayer of that generation, for a favor before I died. I asked if they could protect this castle generation after generation.’ ‘That Dragon Slayer swore an oath that they would keep that promise generation after generation.’ She had asked the Dragon Slayer who swore an oath to the white Dragon to do so. At first glance, it seemed like a promise between two people based on their trust. But would it really be like that? This was something regarding the children she cherished more than her life and having a beautiful death. Would it just have been a loose promise like that? Especially one that involved future generations as well? Cale continued to speak. “What was the oath?” The white Dragon had a sad smile as she responded back. “An oath of death.” It was an extremely strong oath the white Dragon asked the God of Death to make. “The oath was made with the title of Dragon Slayer.” It was a strong and cruel oath that could be continued on to future generations of Dragon Slayers. She then explained the contents. “Do not harm this castle nor anything inside it. Do not get in their way. Do not negatively influence them. Most importantly, do not harm my children in any way. However, you may fight with them if they show you ill will.” The Dragon Slayer who had been the white Dragon's close friend had accepted the conditions of this oath. The white Dragon had been extremely helpful to him and his village. It was also an oath that was not harmful as long as they did not go against it. Cale observed the white Dragon's eyes. “…What would happen if they went against the oath?” The white Dragon calmly answered back. Her low voice reached everyone’s ears. “The moment a Dragon Slayer who breaks this vow appears…” The punishment for going against this strong oath. What kind of punishment would the White Star have received? “Your family, tribe, and anyone precious to you will die.” Cale's shoulders slightly flinched. Everyone was looking at the white Dragon now. The white Dragon just calmly continued on. Their family and anyone precious to them would die. “Only you will be left alone in a world without anyone precious to you, in a world where you cannot cherish anything ever again.” Left alone in the world where they lost everyone. They would live forever without being able to cherish anything ever again. Anyone or anything. Nothing could be cherished ever again. “You will never be able to experience the peace that eternal death has to offer, you will face the most painful death over and over and feel the pain of living over and over again without being able to rest.” Cale let out a gasp. He felt as if all of his strength was leaving his body. He finally felt like he got it. The White Star, a reincarnator. He understood how the White Star ended up being able to reincarnate over and over. At the same time, a question filled his mind. It was a question that came up because he clearly remembered everything that happened with the Dragon half-blood. It was the conversation he had with the Super Rock while walking down the temple corridor on Wind Island to find the top's whip. ‘The White Star was destroyed on the day I died.’ 10,000 years ago. The end of ancient times. The Super Rock had said that he had fought against the White Star with other ancient power wielders. That was 10,000 years ago. However, the White Star had only been reincarnating for 1,000 years. He had said so himself, and it was accurate based on the current situation. In that case, who was the ‘White Star’ that the Super Rock fought against? The Super Rock had said the following about that person. ‘At that time, that person had all five natural attributes along with the sky attribute.’ However, the White Star did not have an earth-attribute ancient power right now. He heard the Super Rock’s voice in his mind at that moment. Cale. Cale started to frown after hearing what the Super Rock said next. The ‘White Star’ of ancient times is a different being than the current White Star. Even though their names are the same. ‘…Their names are the same, but they are different people?’ The White Star of ancient times had his soul destroyed. The ancient powers in his possession were scattered in the world. I'm certain of it. The White Star of ancient times is different than the current White Star. ‘So then how is it that the two of them are acting so similar?’ Cale, I think that the current White Star is mimicking the ancient White Star. Those words hit Cale hard. He then heard the white Dragon’s voice. “The last Dragon Slayer. The one you call the White Star destroyed this castle and stole the eggs.” Cale felt chills throughout his body but could not look away from the white Dragon. The white Dragon held back the full details for Raon, but shared a portion of what happened 1,000 years ago. The bastard who destroyed the inside of the castle and stole the eggs. “The oath of death struck down on that bastard.” The white Dragon could not forget that moment. The bastard who would lose everything he cherished… The bastard who would never be able to cherish anything ever again… The bastard who would never be able to experience the peace and rest that death has to offer… The bastard who would continue to face the cruelest of deaths and pain while repeating his sad and tiring life… “He was smiling.” That bastard had been smiling. “He said that he was waiting for this. He smiled while saying that he was waiting for this oath.” He had smiled extremely brightly after destroying the castle and holding the two eggs in his arms. “He said this would let him become a stronger existence than the Dragons and rule the world.” He then laughed out loud. The corners of the white Dragon's lips were slightly shaking. “I could only watch all of that in my sealed form.” Cale could see the white Dragon who was frowning without laughing nor crying. And once their eyes met… “…That bastard, he is alive, right?” Cale could feel the intense anger buried deep inside the white Dragon’s eyes.	cc/2021-04/en_middle_0036.json.gz/line1095
__label__wiki	0.632015	0.632015	Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study Anna Coppo, Giacomo Bellani, Dario Winterton, Michela Di Pierro, Alessandro Soria, Paola Faverio, Matteo Cairo, Silvia Mori, Grazia Messinesi, Ernesto Contro, Paolo Bonfanti, Annalisa Benini, Maria Grazia Valsecchi, Laura Antolini, Giuseppe Foti Lancet Respiratory Medicine 2020, 8 (8): 765-774 BACKGROUND: The COVID-19 pandemic is challenging advanced health systems, which are dealing with an overwhelming number of patients in need of intensive care for respiratory failure, often requiring intubation. Prone positioning in intubated patients is known to reduce mortality in moderate-to-severe acute respiratory distress syndrome. We aimed to investigate feasibility and effect on gas exchange of prone positioning in awake, non-intubated patients with COVID-19-related pneumonia. METHODS: In this prospective, feasibility, cohort study, patients aged 18-75 years with a confirmed diagnosis of COVID-19-related pneumonia receiving supplemental oxygen or non-invasive continuous positive airway pressure were recruited from San Gerardo Hospital, Monza, Italy. We collected baseline data on demographics, anthropometrics, arterial blood gas, and ventilation parameters. After baseline data collection, patients were helped into the prone position, which was maintained for a minimum duration of 3 h. Clinical data were re-collected 10 min after prone positioning and 1 h after returning to the supine position. The main study outcome was the variation in oxygenation (partial pressure of oxygen [PaO2 ]/fractional concentration of oxygen in inspired air [FiO2 ]) between baseline and resupination, as an index of pulmonary recruitment. This study is registered on ClinicalTrials.gov, NCT04365959, and is now complete. FINDINGS: Between March 20 and April 9, 2020, we enrolled 56 patients, of whom 44 (79%) were male; the mean age was 57·4 years (SD 7·4) and the mean BMI was 27·5 kg/m2 (3·7). Prone positioning was feasible (ie, maintained for at least 3 h) in 47 patients (83·9% [95% CI 71·7 to 92·4]). Oxygenation substantially improved from supine to prone positioning (PaO2 /FiO2 ratio 180·5 mm Hg [SD 76·6] in supine position vs 285·5 mm Hg [112·9] in prone position; p<0·0001). After resupination, improved oxygenation was maintained in 23 patients (50·0% [95% CI 34·9-65·1]; ie, responders); however, this improvement was on average not significant compared with before prone positioning (PaO2 /FiO2 ratio 192·9 mm Hg [100·9] 1 h after resupination; p=0·29). Patients who maintained increased oxygenation had increased levels of inflammatory markers (C-reactive protein: 12·7 mg/L [SD 6·9] in responders vs 8·4 mg/L [6·2] in non-responders; and platelets: 241·1 × 103 /μL [101·9] vs 319·8 × 103 /μL [120·6]) and shorter time between admission to hospital and prone positioning (2·7 days [SD 2·1] in responders vs 4·6 days [3·7] in non-responders) than did those for whom improved oxygenation was not maintained. 13 (28%) of 46 patients were eventually intubated, seven (30%) of 23 responders and six (26%) of 23 non-responders (p=0·74). Five patients died during follow-up due to underlying disease, unrelated to study procedure. INTERPRETATION: Prone positioning was feasible and effective in rapidly ameliorating blood oxygenation in awake patients with COVID-19-related pneumonia requiring oxygen supplementation. The effect was maintained after resupination in half of the patients. Further studies are warranted to ascertain the potential benefit of this technique in improving final respiratory and global outcomes. FUNDING: University of Milan-Bicocca. Effects of the prone position on gas exchange and hemodynamics in severe acute respiratory distress syndrome. P Jolliet, P Bulpa, J C Chevrolet Critical Care Medicine 1998, 26 (12): 1977-85 Additive beneficial effects of the prone position, nitric oxide, and almitrine bismesylate on gas exchange and oxygen transport in acute respiratory distress syndrome. P Jolliet, P Bulpa, M Ritz, B Ricou, J Lopez, J C Chevrolet Critical Care Medicine 1997, 25 (5): 786-94 Short-term effects of prone position in critically ill patients with acute respiratory distress syndrome. L Blanch, J Mancebo, M Perez, M Martinez, A Mas, A J Betbese, D Joseph, J Ballús, U Lucangelo, E Bak Intensive Care Medicine 1997, 23 (10): 1033-9 Improvement in oxygenation by prone position and nitric oxide in patients with acute respiratory distress syndrome. M Martinez, E Diaz, D Joseph, A Villagrá, A Mas, R Fernandez, L Blanch Intensive Care Medicine 1999, 25 (1): 29-36 Recruitment maneuvers during prone positioning in patients with acute respiratory distress syndrome. Wolfgang Oczenski, Christoph Hörmann, Christian Keller, Norbert Lorenzl, Anton Kepka, Sylvia Schwarz, Robert D Fitzgerald Critical Care Medicine 2005, 33 (1): 54-61; quiz 62 Combined effects of prone positioning and airway pressure release ventilation on gas exchange in patients with acute lung injury. T Varpula, I Jousela, R Niemi, O Takkunen, V Pettilä Acta Anaesthesiologica Scandinavica 2003, 47 (5): 516-24 Comparison of prone positioning and high-frequency oscillatory ventilation in patients with acute respiratory distress syndrome. Laurent Papazian, Marc Gainnier, Valérie Marin, Stéphane Donati, Jean-Michel Arnal, Didier Demory, Antoine Roch, Jean-Marie Forel, Pierre Bongrand, Fabienne Brégeon, Jean-Marie Sainty Critical Care Medicine 2005, 33 (10): 2162-71 Intermittent prone positioning in the treatment of severe and moderate posttraumatic lung injury. G Voggenreiter, F Neudeck, M Aufmkolk, J Fassbinder, H Hirche, U Obertacke, K P Schmit-Neuerburg Critical Care Medicine 1999, 27 (11): 2375-82 Clinical meaning of early oxygenation improvement in severe acute respiratory distress syndrome under prolonged prone positioning. Kwangha Lee, Mi-Young Kim, Jung-Wan Yoo, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh Korean Journal of Internal Medicine 2010, 25 (1): 58-65 Prone positioning improves oxygenation in spontaneously breathing nonintubated patients with hypoxemic acute respiratory failure: A retrospective study. Vittorio Scaravilli, Giacomo Grasselli, Luigi Castagna, Alberto Zanella, Stefano Isgrò, Alberto Lucchini, Nicolò Patroniti, Giacomo Bellani, Antonio Pesenti Journal of Critical Care 2015, 30 (6): 1390-4	cc/2021-04/en_middle_0036.json.gz/line1097
__label__cc	0.680608	0.319392	← AL PERLEE Tom Decker and Jeff Parrish → Raphael Reda Posted on January 28, 2013 by Erwin A. Dence Jr. under Uncategorized “You have to meet this guy. He’s a surfer. Like you. He’s a real goofball. Like you.” George Hoppe, in reference to Raphael Reda. It seems I should write these things in reverse order; starting with the most recent event. Then, as they’re posted, a reader could come forward in time. Actually, one story, even in the planning/remembering phase, leads to another. Once I had written that I’d visited Al Perlee’s surf shop more than twenty years ago, I now feel compelled to mention the circumstances and who I was with when we were told that we could not enter The Surf Shop in Westport in our wetsuits. No way. It was 1988. Raphael Reda actually put up an argument. “It’s a surf shop.” He looked around as if suggesting the building was not all that fancy. “And we’re surfers.” “Yeah. So?” “And we’re planning on going back out again.” The shop, two disheveled surfers at the door, looked, and looks, kind of like it was a converted garage, with another converted garage added on, not necessarily built by professionals. Still, it was filled with boards and wetsuits and magazines and stuff surfers find fascinating. Mostly it offered the chance, out of a parking lot, to lean on a counter and regale whoever’s there with stories; hopefully enlighten and entertain someone who hears surf stories pretty much non-stop during business hours. “Epic! All time! Classic!” But we were outside. “We tried the jetty; now we’re going to try the groins.” “Well, then (nodding as if the groins might be a better choice); come back after that. (appropriate pause) Dressed.” Raphael and I were in Westport to practice- not just to surf- we were practicing for the upcoming Westport Longboard Contest. The annual event had been started several years earlier by Ricky Young. A former top rated competitive surfer, he sold surfboards in Bellevue, a city across Lake Washington from Seattle, commonly called the “Eastside.” Still, Ricky was able to line up sponsors, organize volunteers, line up surfers and judges. At this time, I was still working as a sign painter at the Puget Sound Naval Shipyard. While the real work was on ships, I worked mostly in a shop, making me a “Shop Pogue.” I don’t think Pogue is a term of endearment. My friend George Hoppe had also moved from the discomfort of the ships to the relative grandeur of operating a spray booth in a large building. He, evidently, had paid enough shipboard dues to not suffer ridicule for his plusher surroundings free of bilges and tanks and endless wireways and pipes. Besides, George was not a person to be messed with. He was confrontational, a master of blue collar repartee, a sort of Don Rickles of the paint shop, with, merely as an example, a creative list of responses to ‘fuck you.’ George and I got along, perhaps, because I laughed at any putdowns directed towards me, and I could talk way faster than he could, and, well, I could keep up in the repartee department. George, frequently would get me started on a subject, then stand back, say, “He’s on a roll now.” Raphael was a carpenter, and, since I didn’t go over to the Shop 64 building to meet him, George brought Raph over to my desk/drawing table. With George observing, Raphael and I did the “Surfer Sizeup.” This process begins with an exchange of experience; where and when and how one ended up at this location. “South Bay.” “North County.” “Dewey Weber.” “Surfboards Hawaii.” “Malibu, a few times.” “Swamis, all around; Doheny, before the breakwater.” “Had to get away. Didn’t’ want to raise kids there.” “Yeah, same thing.” Soon enough, with George having gathered a couple of other non-surfers to witness, Raphael and I got appropriately goofy. “Epic!” “All time!” “Classic!” “Next,” George said, “They’ll be doing the surfing poses.” I don’t recall seeing Raphael when he wasn’t enthusiastic, supportive. Somewhere after I left the shipyard, he (or his wife, Grace, not actually clear on this) inherited a large sum of money, moved to the canyons of Topanga, near Malibu. What George (or I) would say is that he had so much money he had to get divorced. Through another shipyard/surfer, Jim Kennedy, someone I run into every now and again, out at Westport, up on the Straits, Ralph (Jim’s version of Raphael) bought land (new land from lava) on the Big Island. It was either that or his land was covered by lava. The last time I heard from Raphael, he, knowing I’d written several screenplays, sent me his. It had a good story, mostly bad dialogue. One line was excellent- I stole it for one of my probably-never-to-be-sold scripts. Then he sent me a link to a YouTube video of him, captain of his own tour sailboat, crashing through several waves closing out the Ala Wai Yacht Harbor. I wrote back asking if he was the Captain, at the wheel, or the guy hanging on to something at the bow; and if it was a “three hour tour; a three hour tour.” “The Captain, of course. You know, Hoppe always said you were goofy.” This entry was tagged Al Perlee, George Hoppe, Jim Kennedy, Raphael Reda, real surfers, Ricky Young, Surfer Size-up, surfing, Westport. Bookmark the permalink. One thought on “Raphael Reda” I love this story. I can envision it completely. FYI… It was Raphael who inherited the money from his Uncle Don Reda.. And he did buy property in Topanga Canyon, CA (sold it to Tia Carrera) and now he is in Hawaii with his 2nd wife Marina (from Transylvania, Romania) Binge-Watching History	cc/2021-04/en_middle_0036.json.gz/line1099
__label__wiki	0.831153	0.831153	HC issues notice to Centre, state over listing royal property in Rajasthan The division bench of chief justice Sunil Ambwani and justice Ajit Singh issued the notices on a PIL by the Lok Sampati Sanrakshan Samiti through secretary P N Maindola on Tuesday. The court directed the replies be filed within 4 weeks and posted the next hearing on Sept 15. PJ Joychen JAIPUR: Rajasthan high court has on Tuesday issued notices to the Centre and the state governments over not publishing the list in official gazette of the immovable properties of the Rajasthan state and the 21 princely states of Rajasthan as per the covenant entered with the erstwhile rulers of Rajasthan and the government of India. The petitioner said as per the provisions of Article XII of the covenant, two types of list had to be published-the list of private properties of ex-rulers and the list of properties which would be transferred to the united state of Rajasthan. But no such list of properties in respect of the ex-rulers of Rajasthan have been published in the official gazette till date. It said in the process of the re-organization of the united state of Rajasthan, the representatives of ex-rulers of Jaipur submitted a list of properties with reference to Article XII of the covenant to B P Menon, the then political advisor to the central home minister . But the list detailing the properties belonging to the state of Rajasthan and of the ex-rulers of the then Jaipur state is yet to be verified/ certified and published in the official central gazette. The petition further said taking advantage of the above lapse the ex-rulers and their heirs have transferred many of the immoveable properties of the state of Rajasthan in their names by forming personal trusts under the provisions of the Rajasthan Public Trust Act 1959. For instance the petition pointed out that in an official meeting on June 29 1982, the then state minister Local self government of Rajasthan said Aatish market in Jaipur and Zanbasha of Alwar are belong to the state of Rajasthan. But contrary to the above decision the then UDH minister in an official meeting in Oct 19 2004 directed that Aatish market is not state property but belong to the ex rulers. Thus the state functionaries illegally singed MoU with the heirs of the ex rulers allotted 15 bighas of land at Jagatpura in lieu of the Aatish market ground. He said the same situation persist with respect of other ex rulers. Most Read in Regulatory Stamp duty waiver helped Maharashtra's revenue grow by Rs 367 crore	cc/2021-04/en_middle_0036.json.gz/line1100
__label__cc	0.586891	0.413109	Posted on 08/05/2014 08/05/2014 by Lisa Smith Spring: when thoughts of fancy turn to itchy, watery eyes By Lisa Smith A number of my Tweet-friends have recently been complaining about the severity of their hay fever this spring. @KateMorant asked: Is there any #earlymodern advice/ recipes for hay fever? I’ll try anything short of applying leeches to eyes. Advert for Histantin, a Burroughs Wellcome and Co antihistaminic agent showing a couple eating a picnic in a field while a farmer piles hay onto a cart, 1965. Image Credit: Wellcome Library, London. But… trying to figure out what people might have used to treat their symptoms in early modern England is no easy matter. The term hay fever, according to the Oxford English Dictionary, was not used until 1829. What we know now as “hay fever” was first described in 1819 by Dr. John Bostock, who presented his own case for study as being “an unusual train of symptoms”: itchy, swollen and watery eyes, sneezing, and difficulty breathing. Over the years, Bostock had tried bleeding, purging, blisters, diet, Peruvian bark, steel, opium, mercury, cold bathing, digitalis… and, of course, many eye remedies. None of these had apparently helped. Keeping in mind the relatively new description of hay fever as an ailment, I decided that the best way to track down early modern hay fever remedies would be according to symptoms. Of the symptoms typically associated with hay fever, itchy eyes are the easiest to trace—and even this was no mean feat. I started off with the Wellcome Library’s wonderful online collection of seventeenth and early eighteenth century recipe books. Although there are lots of remedies to treat eye problems, many of these were a bit general, such as “The Lady Iveys Eye Watter” listed in the Johnson Family’s book (1694-1725). These eye drops, which included the white of a new laid egg, spring water and alum, could be used to treat “all distempers in yr Eyes pertickuler for any thing that grows”. So, although allergy-ridden eyes could in theory be treated with this remedy, it was not the most specific choice. Fortunately, none of the remedies I looked at used this as an ingredient! Thomas Rowlandson, A Village Doctress Distilling Eyewater, 1800. Image Credit: Wellcome Library, London. The Brumwich family (1625-1700) may have been hay fever sufferers, as there were three somewhat more useful remedies in their collection: “A watter for eyes that are red & watterey aproved”, “A resceipt for wattering eyes” and “A water for sore eyes whose lides are all swelled”. All had an “X” or a “+” beside them, indicating—along with the one “aproved” that the recipes had been tried. The “watter for eyes” was essentially a sugar water that could be sponged or dropped into the eyes, while “A resceipt” included orris [iris] root and white copris [possibly a beetle?] steeped in water. The “water for sore eyes” used red rose water and powdered aloes. Of course, there is no guarantee that these were for allergy symptoms, especially as the third recipe was included alongside remedies for blindness and sore eyes. None of them give me any confidence. The English Physician enlarged (1718) by Nicholas Culpeper, however, offered some potential explanations—as well as solutions—for itchy, watery eyes. A juice of celandine, field daisies and ground ivy in clarified water with dissolved sugar was a “soveraign remedy for all pains, redness, watering”, which sounds promising, but it also treated pins and webs and skins and films (p. 10). Barley, which was ruled by Saturn, could be cooling and cleansing, especially for inflammation problems (pp. 29-30). Eye drops distilled from green barley gathered at the end of May was particularly good for sufferers who had “Defluctions of Humours fallen into their Eyes”. Both remedies suggest that symptoms might be seen as defluxions (a discharge of fluid) or inflammations. Makes sense. But another type of classification in Culpeper put itchy, swollen eyes alongside poisons and the venemous bites. This made sense; the blood in such cases was seen as poisoned and overly hot. White beets and borage and bugloss were all ruled by Jupiter, which made them cleansing and strengthening. The beets could treat internal obstructions, headaches, venemous bites, eye inflammations and—interestingly—“wheals”, something rather like a hive (pp. 36-37). Borage and bugloss roots and leaves were good for putrid and pestilential fevers and poisons, while the leaves and seeds might help cleanse the blood and excess heats. The distilled water could be used as an eye wash for red and inflamed eyes (pp. 50-51). Modern hay fever sufferers, no doubt, will also understand this parallel with poisoning, with pollen and dust acting as daily sources of misery. Trying to identify hay fever-like symptoms in early modern England is a difficult business, as these eye remedies reveal. And this, before we even get to the sneezing! A quick digital search through Culpeper’s on Eighteenth Century Collections Online shows that all references to sneezing were in positive terms. For example, under “Clary, or more properly Cleer-Eye”, Culpeper noted that the powder of the dry root “provoketh Sneezing and thereby Purgeth the Head and Brain of much Rheum and Corruption” (p. 90). In other words, while Culpeper offered up lots of remedies for the eye symptoms, nothing could—or should—be done about the sneezing. Sneezing: nature’s way of purging the body? But at least no leeches were required… CategoriesBody Parts, Early Modern, Lisa Smith, Medicine, Remedies, Wellcome Library Tagsallergy symptoms, eyes., hay fever, sneezing, symptom classification 5 Replies to “Spring: when thoughts of fancy turn to itchy, watery eyes” Kate Morant says: Thanks very much for the helpful advice, Lisa – and I’m even now assembling my distilling apparatus to produce eye drops from some recently-picked green barley. I thought, given the charming illustration of the methods of a village medical practitioner, it would be worth refining the product myself than to trust the stock of my local apothecary. Lisa Smith says: Good luck… may you find something more effective than barley water and the doctoress’ special distilled water. Pingback: Giants’ Shoulders #71: The better late than never, crack of doom, almost didn’t make it at all, sometimes life is like that, SNAFU edition. \| The Renaissance Mathematicus EyeSoothe says: Thanks for the advise. Several natural remedies and treatments have been used to treat eye allergies, including itching and redness. But make sure to contact your doctor about the safety and effectiveness of these remedies before you try them. Talk Hay Fever says: I often surf the internet these days searching solutions to my alergies. I like to research about new ideas, things that I may not have tried before. I really enjoyed reading the posts on your site. Thank you for sharing. Previous PostPrevious First Monday Library Chat: The College of Physicians of Philadelphia Next PostNext The Medieval Invisible Man	cc/2021-04/en_middle_0036.json.gz/line1103
__label__cc	0.51023	0.48977	All Film, Horror, Ranked Top 20 Horror Movies of 2020 Date: December 31, 2020Author: redmangoreviews 0 Comments Sommerleigh Pollonais, Horror Head Writer If there was one silver lining in this year of, well let’s call it what it was, the weirdest apocalypse ever, it would be that people probably watched more movies and television shows than usual. Lockdown meant we needed to find an outlet for our stressful days, and watching horror movies have always been one of the best ways (besides getting your killstreak on in your favorite video game) to face your fears without having to worry about any actual real world repercussions. It’s been a good year to be a horror fan and even if you’ve seen a lot of them, there are always those hidden gems that slip under your radar. So with this in mind I’ve put together the best of the best of MY favourite genre, for you to enjoy. Here are the TOP 20 BEST HORROR MOVIES OF 2020. #20 La Llorona I have heard this is really great for your skin A fresh spin on a familiar legend, set exceptionally well against the backdrop of a real life horror, La Llorona (not to be confused with Blumhouse’s Curse of La Llorona) tells the story of an aging war criminal who, after being acquitted of his crimes, finds himself and his family being haunted by the ghosts of his past. Well shot and emotionally impactful due to the real life connections (the genocide of native Mayans in Guatemala), this was a slow burn with a strong start, a bumpy middle and overall a solid use of this terrifying supernatural entity. #19 The Wolf of Snow Hollow Nice to see Wolf Cop is still getting work An above average werewolf movie is hard to find (trust me, I’ve looked). And as a fan of this furry bastard, I’m always on the lookout for an enjoyable creature feature that has him on full display. With a great looking werewolf and a nice whodunit at its core, this movie does a good job of giving audiences a modern day werewolf movie with a twist. Sadly, I didn’t enjoy it as much as I wanted to, as the lead character got on my nerves. Still, this is one werewolf movie that’s a cut above the average fare. #18 #Alive Come on guys. You have been in quarantine all of two days A fantastic zombie horror that incorporates modern technology both as a saving grace and as a warning to those who live their lives completely disconnected from the real world. This South Korean flick delivers the thrills, chills and loads of adrenaline that can sometimes be lacking when you’re dealing with the shambling undead. It more than made up for the disappointing follow up to the stellar Train to Busan. This is a zombie movie any fan of the genre would delight in. #17 1BR Feel that rhythm. You can’t tell me that’s not Gangnam Style It’s one of those fears you don’t see often in horror movies (fear of your neighbors), but when it’s done right (Rosemary’s Baby/The Burbs), it can be just as impactful as any other sub-genre of horror. 1BR is the story of a young woman who thinks she’s found the perfect apartment to rent, until she realises her neighbours take the whole “housing rules and regulations” thing to the extreme. It doesn’t have a big budget, but more than makes up for it with strong performances, claustrophobic settings, and an ending that will leave you chilled to the core. #16 Scare Me I am sure this will not end well Just when I thought I had seen every kind of horror movie there is, Scare Me hits me with one of the strangest. An inspiring novelist rents a cabin to try and write his dream book. He meets with another writer who is also staying nearby and, unlike him, she’s the real deal. They get together and decide to see who can tell the scarier story. And the rest? Well you’ll just have to see it for yourself. With scenes that feel heavily improvised and a tone that switches from humorous to horrific as the story unfolds, Scare Me may not be the scariest horror movie I’ve ever seen this year, but it was definitely one of the most original and engaging. #15 Scare Package If I only had a brain… I’m always on the hunt for good horror anthologies and this year, we got two of them! Scare Package is the first on my list and, unlike most other anthologies I’ve seen, it’s extremely self-aware and embraces its comedic side with both bloody hands. The main story that connects them all is very rough, unlike say, Trick ‘r Treat, but it’s filled to the brim with blood, gore and lots of love for fans of the genre. And it’s the kind of movie that’s a blast to watch with your horror-loving friends. #14 The Platform Yeah, I’m full. Thanks, though Non-horror fans tend to dismiss the genre as gratuitous. To that I say, go watch a movie like The Platform and tell me horror doesn’t know how to be smart! The social commentary here never overtakes this striking and visceral analogy for the selfish nature of humanity. Simply put, if everyone takes only what they need, we could all thrive. And The Platform takes this powerful message and delivers it with grisly abandon. It’s clever, it’s chilling and it’s definitely worth watching if you missed out on it. #13 The Lodge Hello darkness my old friend… The Shining meets Martha Marcy May Marlene, The Lodge is a lesson in the importance of dealing with your emotional wounds, lest it returns in horrific ways. A woman who has lived through some serious trauma (she survived a mass suicide cult) is left alone with the children of her new boyfriend in the snowy, titular lodge. The kids are still grieving for their dead mother and their actions culminate in a finale that makes the ending of The Mist look like a happy fairytale. If you like your tension delivered with a slow meticulous burn, The Lodge is the vacay spot for you. #12 Black Box No you don’t look ridiculous at all If Total Recall was a horror movie, it would look a bit like Black Box. The best of the “Welcome to the Blumhouse” group of movies released this year, this movie tells the story of a man who has lost his memories after an accident that also claimed the life of his wife. His memories are fractured and he goes to a doctor who utilises tech called, (say it with me) the Black Box, and in doing so he regains memories, but they may not be his own. The acting here is what elevates this story, and while there are stumbles balancing the genres of science fiction and horror, the directing is astute enough to ultimately pull it off. With an excellent twist in the third act and a finale that leaves us open to a sequel, Black Box is a strong debut by first time director Osei-Kuffour Jr and I’m looking forward to seeing what he brings us next. #11 Spontaneous And then she went ‘kablooey’! A twisted spin on the terrors of being a teenager, Spontaneous will instantly catch your attention with an opening scene that is, in a word, explosive. Whip smart and with a wicked sense of humor, this movie is a fantastic send-up of other genre films like Donnie Darko and Heathers, it never bothers to weigh down viewing audiences with too much scientific info or overly tedious explanations and just revels in the madness and the fun. With a rare, unpredictable nature you don’t usually see in horror (you have no idea who’s gonna explode at any given time) this is one movie that gloriously lives up to its name. #10 Freaky Wedding Crasher? More like non-wedding slasher! Yeah, that didn’t work at all. Let’s just move on A fun spin on a well-worn trope, Freaky follows in the footsteps of Happy Death Day, which added a horror spin to Groundhog Day, and takes the “body swapping” of Freaky Friday and shakes things up by making the two main “swappers” an ordinary teenage girl and a serial killer. With some fun slasher moments that would make Jason Voorhees envious, and a great comedic lead in Vince Vaughn, Freaky is one of those horror movies you can sit back, nibble away on a bowl of popcorn, and just enjoy a solid slasher flick for the ages. #9 His House So it’s a bit of a fixer-upper… When the ghosts of your past literally haunt you there’s no place safe to hide, not even your new home. His House is another superb addition to the genre that utilises horror to tell a much deeper tale. The tragedies suffered by our two leads, migrant couple Bol and Rial, are a real-life horror that most of us will thankfully never experience. The brilliance of this film is the way their experiences and the choices they made to escape the atrocities in their homeland of South Sudan are manifested as the kind of visual horror that makes your hair stand on end. With perfect, deliberate pacing, a great use of light and shadow, and the kind of acting reserved for Oscar-caliber films, His House is an instant classic which will stand the test of time along with similar films like The Others and The Haunting (1963). #8 Host I feel you guys. These Zoom meetings are tre stressful If ever a horror movie was perfectly made for the year 2020, it would be this one. A British found footage horror movie, but shot in the style of another genre winner, Searching, Host tells the story of a group of friends who, with seemingly nothing better to do (have these people never heard of video games?!), decide to have a séance. When crap inevitable goes sideways we are forced to witness, through the claustrophobic lens of their laptops no less, the gruesome demise of these foolish people, as a demon picks them off one by one. Using laptops/phones to shoot this movie was a stroke of genius as the narrative lends perfectly to this visual style. And it causes us the audience to be forced to look directly into our screens as we try to make out what’s standing right out of frame, or is casting shadows, or making the lights flicker. With those “look behind you!” moments that have you yelling at your screen, Host will leave you hitting “end call” faster than you can say Boo! #7 Sputnik I could use a drink. Vodka. Make it a double An ode to classic sci-fi horror movies of the 60s and 70s, this is a Russian tale of an alien that forms a parasitic/symbiotic bond with an astronaut. The man finds himself locked away as his superiors try to figure out what to do. While stories like this one aren’t new, the Russian spin on it does make it feel that way, and I appreciated seeing how different they may have dealt with something like this happening on their side of the world. With sharp visuals and equally dramatic and thrilling moments, Sputnik has the right mix of smarts and sinister that any fan of the sci-fi horror genre can instantly get behind. #6 Relic Hey grandma. How you doing? Some horror movies are harder to watch than others, at least, those which may hit close to real life fears. Relic tells the story of a woman whose mother has gone missing. So she returns to her childhood home with her daughter to find her, only to have her mother show up on her own. But there’s something wrong with Grandma and they have to find out what before it’s too late. A somber and chilling analogy of growing old and developing ailments that can affect your mind, like Alzheimer’s, with visuals that directly tie into the decaying state of this family’s matriarch mind, and terrifying spectres (real or imagined) haunting this family, this is the kind of movie that audiences who prefer nuance with their nightmares will appreciate. #5 Underwater Just keep swimming my a— This is one of those movies that I appreciation of it grew the more times I’ve viewed it. Underwater may be inspired by films like The Abyss and Leviathan, but it also stands solidly on its own. With claustrophobic settings (the drilling site here is thousands of leagues beneath sea level) and extremely original designs for the deep sea creatures that are picking off this crew one by one, the story makes use of not just the fear of the unknown, but the fear of being completely out of your natural element and fighting to survive at every turn. If the monsters don’t get you, the atmosphere (or lack of it) will, and with an ending that you will never see coming, Underwater, like Event Horizon, is one of those movies I think people will grow to appreciate more as time goes by. #4 Color Out of Space Notice anything different? HP Lovecraft’s work has always been some of the most difficult to adapt. Otherworldly in every sense of the word, most movies that attempt to do so fall flat. That’s not the case with this trippy send-up, inspired by the works of the famed author, Color Out of Space. With visuals that look like an acid trip, loads of blood and gore, and the icing on any crazy cake, Nicolas Cage as the patriarch of a family who sees a large meteor land in their backyard and well, the rest you need to see for yourself. Nutty in the best ways possible, if you’re a fan of the kind of crazy horror flicks that were usually only made in the 80s, this one is ripe for the picking. #3 The Mortuary Collection Sure. Tap on the glass case with the creepy thing inside. What a capital idea! The other anthology horror film I saw this year, The Mortuary Collection is a fine addition to the sub-genre. Sharp visuals, great production value, and all well-crafted stories connected by a solid main plotline (director Ryan Spindell also worked on web series 50 States of Fright) this anthology is one of the best I’ve seen since Trick ‘r Treat. And with Clancy Brown (Highlander, Starship Troopers, The Shawshank Redemption) delivering as the head of the mortuary, you know you’ve got something truly special in this collection. #2 Possessor I told you not to listen to the whole Lana Del Rey album in one sitting but noooooooooo David Cronenberg’s son Brandon proves the apple, or in this case, nightmare-inducing apple, doesn’t fall far from the tree with his body horror film Possessor. It is a macabre and brutal version of body possession (that in this story doesn’t require any demons but instead is based in science fiction) as a woman named Vos takes possession of unwitting victims and forces them to pull off assassinations. Stay far away from this one if body horror isn’t your thing, but if it is, the visuals here will not leave you wanting more. And the acting by Andrea Riseborough and Christopher Abbot completely pull you into this unapologetically gruesome world. And here I thought The Fly was the grossest movie I’d ever seen! Runner-up: The Invisible Man I’m telling you, I’m really a handmaid in a dystopian society The only reason this movie didn’t make #1 for me is, while I enjoyed every minute of it, the story didn’t creep me out half as much as my top pick did. That said, what writer/director Leigh Whannell did with his updated version of this classic character is nothing short of amazing. Starring the versatile and talented Elizabeth Moss as our lead heroine, Cecilia, a woman who has to go on the run from her abusive boyfriend Adrian (Oliver Jackson-Cohen). After being told he has died, she thinks it’s finally okay to come out of the shadows, but when strange things start happening to her, Cecilia suspects Adrian might be closer than anyone realises. There is so much to appreciate here, from the ingenious way Whannell frames a room, making you the viewer just as paranoid as Cecilia, to the “upgraded” ideas behind what makes the Invisible Man, ahem, invisible, and the great performances by everyone involved, this thriller never fails to keep your attention. One of my favourite parts is the one in the mental hospital when Adrian goes up against the guards. Whannell hasn’t directed many movies, but the camera tricks he used in his other fantastic genre outing, Upgrade, is on full display in this scene and works perfectly here to show how trippy (and terrifying) it would be to fight something you can’t see. Not just one of the best horror movies for 2020, but one of the best movies of the year period! Here’s hoping we get to see The Invisible Man (or woman) back again very soon. #1 The Dark and The Wicked Hello Mr Creepy Silhouetted Stranger. What can we do you for? The Exorcist would be proud. The Dark and The Wicked tells the tale of two siblings who return to their parents farm to await their father’s passing, as he has taken ill and cannot be moved to a hospital in fear he will pass away during transport. What could’ve easily settled for silly jump scares and loads of gore instead goes the smart route of slowly, ever so slowly, wearing on both the nerves of these characters as well as you, the viewing audience. While there are those expected “boo!” moments, the film crawls under your skin with a great score and those quiet, creepy moments, like the creak of a floorboard, shadows where there shouldn’t be any, and loads of other subtle scares that build on the ominous nature of the story unfolding. And the actors here give there all in creating characters you can connect to, and in doing so characters you are terrified for, as you get closer and closer to the inevitable conclusion. I devour tons of horror movies every year, so for someone such as myself to sing praises to one of them, you know this movie has a lot more to it than just another demonic tale. I recommend watching with headphones on and the lights dim low, as something dark and wicked is definitely coming your way. So that’s it, my best of the best this year in horror. Thank you to all my readers for your continued support, not just in the horror section here (you guys know I love ALL movies right?) but on the site as a whole. It’s one of my greatest joys, talking about movies with my friends and seeing how much you guys enjoy what we at RMR are doing makes it all the more worthwhile. So let’s leave this crazy year behind and keep pushing towards a better tomorrow. Here’s to a New Year and a new batch of films to enjoy! For my Top 10 Horror Movies of the Decade you can click here. And for our horror catalogue, including full-length reviews for many of these entries, you can click here. Previous Previous post: Wander Darkly is a Poignant, Surreal, and Passionate Drama Next Next post: Chilling Adventures of Sabrina Final Season Review	cc/2021-04/en_middle_0036.json.gz/line1105
__label__cc	0.564733	0.435267	ABC stations throughout the show 38 games during two stints Kendall Fuller Jersey The play focuses on Berra and his wife Carmen . • The Big3 and http://www.chiefsnflofficialshop.com/Nike-Kendall-Fuller-Jersey.html CBS Sports have extended their alliance for the league’s upcoming fourth season, with CBS Sports featuring 24 games over the ten event days of the season, with all selected games Wholesale MLB Jerseys airing live on CBS . Once Kendall Fuller Jersey approved, the deal would compensate all retired players, pay for medical exams and fund research, which also applies to the families of deceased players involved in the concussion lawsuits, half of the money would be paid Cheap Jerseys out over the next three years, the rest over the remaining 17 years of the 20-year agreement. Detroit Lions 4. In the spot, an array of people address the question, What are you hoping for this season? Pittsburgh Steelers 19. Carolina Panthers 8. Charles will rip Shaq about Gold Bond, and it’s not so much what he says but the reaction. The 29-year-old has been Cheap Jerseys NFL on quite the journey. Las Vegas Raiders 13. Built in 1923, the building is modeled on Cheap Jerseys the Bargello Palace in Florence, Italy with a stunning inner courtyard. To find all players born within a certain month and year, for example all players born in December of 1985, choose the month and year Kenny Clark Authentic Jersey with the drop down boxes and then choose the ‘Month and Year Wholesale MLB Jerseys Search’ option. Sponsorship spend on performing arts has risen in each of the past five years, from $923 million in 2014 million in 2013 and $891 million in 2012. 9; and for PS 3 No. Kobe Bryant 7. Pittsburgh Steelers 19. U18 Euro Championship B. Lionel Cheap Jerseys NFL Messi 3. 29 • Global lifestyle brand Sanrio, Inc., has signed a deal to become an official partner with Team USA for Nike NFL Jerseys Supply the 2020 Tokyo Olympic and Paralympic Games. Black also faces drug, weapons and sexual assault charges in other states. 21 – Trae Young scored 47 points Saturday, going 14 of 30 from the field, as the Atlanta Hawks lost to the Brooklyn Nets 122. Dad, are you wearing my new gear? Keisuke http://www.nflpackers.us.com/Kenny_Clark_Jersey Honda 10. Arizona Cardinals 9. • Sabrina Ionescu of the University of Oregon Ducks women’s basketball team, who earlier in the day spoke at the Celebration of Life for Kobe and Gianna in Staples Center, has become the first player in NCAA D-1 basketball history – male or female – to reach career numbers of 2 points, 1 assists and 1 rebounds. But some analysts believe that the NFL will not lose the war itself. Denver Broncos 16. Naomi Osaka 4. • The Big3 and CBS Sports have extended their alliance for the league’s upcoming fourth season, with CBS Sports featuring 24 games over the ten event days of the season, with all selected games airing live on CBS . Denver Broncos 16. The BYU fans, apparently disappointed with the score of the game started throwing things on the court. Dallas Cowboys 18. Serena Williams 3. Chicago Bears 20. Boozer went for X-rays, and Okur for an MRI exam Thursday that came back negative for more serious injuries. Atlanta Falcons 17. Will Cousins and Co. 5 – Robert Williams scored six points Tuesday, going 3 of 4 from the field, as the Boston Celtics topped the Cleveland Cavaliers 119. Delaware North Sportservice partners include the Texas Rangers’ Globe Life Park, Milwaukee Brewers’ Miller Park and the Cincinnati Reds’ Great American Ball Park, site of the 2015 All-Star Game this July. Only 39% of Super Bowl 50’s advertisers will score big on their Super Bowl investments, significantly lower than the 13-year historical average of 49% according to the conducted by brand engagement Nike NFL Jerseys Supply and consumer loyalty research consultancy Brand Keys, NY. • Sabrina Ionescu of the University of Oregon Ducks women’s basketball team, who earlier in the day spoke at the Celebration of Life for Kobe and Gianna in Staples Center, has become the first player in NCAA D-1 basketball history – male or female – to reach career numbers of 2 points, 1 assists and 1 rebounds. We fan events, NBA legends, other activations to drive awareness. We plan to use American Airlines Center for some events, other locations in the area. hockey jerseys cheap https://itmi.or.id/2020/01/28/working-two-minutes-will-also-in-the-mainly-adoree-jackson-womens-jersey/ http://mineralmania.co.uk/index.php?option=com_content&view=article&id=647	cc/2021-04/en_middle_0036.json.gz/line1107
__label__cc	0.511589	0.488411	researchchemforum.com Question: What Is Systemic Approach In Family Therapy? What do systemic approaches focus different from individual therapeutic approaches? What do you mean by systemic? What are examples of systemic diseases? What is another word for systemic? What techniques are used in family therapy? What is systemic thinking in family therapy? How does systemic family therapy work? How do you use the word systemic? What is Systemic Family Practice? What is the goal of family systems therapy? What is the systemic approach? What is a systemic approach in Counselling? Systemic therapy is a form of psychotherapy, which seeks to address people not on individual level, as had been the focus of earlier forms of therapy, but as people in relationships, dealing with the interactions of groups and their interactional patterns. Defines the larger social system in which the individual lives.. Systemic refers to something that is spread throughout, affecting a group or system, such as a body, economy, market or society as a whole. Systemic means affecting the entire body, rather than a single organ or body part. For example, systemic disorders, such as high blood pressure, or systemic diseases, such as the flu, affect the entire body. An infection that is in the bloodstream is called a systemic infection. Systemic Synonyms – WordHippo Thesaurus….What is another word for systemic?systemwidebodywidewidespreadcorporal4 more rows There are a range of counseling techniques used for family therapy including:Structural Therapy. Structural family therapy is a theory developed by Salvador Minuchin. … Strategic Therapy. … Systemic Therapy. … Narrative Therapy. … Transgenerational Therapy. … Communication Therapy. … Psychoeducation. … Relationship Counseling.More items…• Systemic thinking is central to the specialty of couple and family psychology (CFP). … Systemic thinking is applied to professional practice in CFP, recognizing that psychotherapy with multiple individuals concurrently in couple or family formats presents particular challenges. How does Systemic Family Therapy work? The therapists work as a team to help people find their own ways to deal with difficulties- ways which work for them and for those around them. … They offer support and guidance to help families see their problems differently and to work together on changes that might be useful. Examples of systemic in a Sentence Adjective The company made some systemic changes to the way it operated. The problem seems to be systemic. These example sentences are selected automatically from various online news sources to reflect current usage of the word ‘systemic. Systemic family practice thinks about the relationships and interactions which exist between family members. This is based on thinking that every person is affected by the people around them, and that one part of the family cannot be understood in isolation from the rest. The goal of family systems therapy is to find out how the family as a whole affects individual members of the family. By teaching the family how their various systems work, they can learn how to work in harmony and bring each other up, not knock each other down. The systemic approach refers to an analysis method; a way to handle a complex system with a global point of view without focalizing on details. It aims for a better understanding of complexity without simplifying reality too much. … It is a way to learn how the systems work. Systemic therapy seeks to understand the individual in relationship with others, rather than in isolation. … Systemic therapy seeks to identify deeply entrenched patterns within an individual’s relationships and also with family members. What Is The Use Of Colour Picker Tool? What is the use of the color picker tool? Quick Answer: Is Beer Cheaper At Walmart? What is the cheapest booze? 10 Delicious Bottles That How Do Dealerships Make Money On Leases? Is it worth buying car at end of lease? The buyout What Is MBO PPT? Is the first step in the MBO process? The six steps Question: Who Is The Top 10 Richest People In The World? Who is the poorest man of the world? man Jerome KervielThe Question: How Do I Cash Out My Uber Cash? How do you remove cash from Uber? Uber Cash will be Are Business Lunches Deductible In 2019? Can you write off business meals in 2019? How Do You Do A Brainstorming Session Remotely? What are the rules for a brainstorming session? Quick Answer: What Does Shrinkage Mean? What is shrink in Walmart? One of the biggest problems Quick Answer: Why Is McDonald’S Coffee So Hot? How do you drink coffee when it’s hot? Question: Who Is The Richest Female News Anchor? What is the average salary of a Fox News anchor? Question: What Are The Four Phases Of A Project? What is the most important phase of a project? Quick Answer: Is It Healthy To Be Lazy? Are lazy people smart? So it’s not hard to see © 2021 researchchemforum.com	cc/2021-04/en_middle_0036.json.gz/line1113
__label__cc	0.52127	0.47873	History 193: Colonial/Revolutionary America and the Atlantic World Getting to Know Your Topic Articles on Your Topic Books on Your Topic Getting Items that Tufts Doesn't Own Using Google? Read This First! by Micah Saxton Last Updated Sep 22, 2020 56 views this year by Micah Saxton Last Updated Nov 12, 2020 175 views this year Welcome to the Tisch Library guide for HIST 193: Colonial/Revolutionary America and the Atlantic World. Use the table of contents to find definitions, topic overviews, books, articles, and more that will help you with your research. If you don't find what you are looking for or need help navigating this guide or any of the resources it contains, don't hesitate to contact the author of this guide or Ask a Librarian. Specialized reference sources--like dictionaries and subject encyclopedias, provide overviews of topics and descriptions of concepts and ideas. They can also provide definitions, statistics, and other details. You can use this type of source to help narrow your research topic, find data to support your thesis, and identify keywords and main ideas to use as search terms. This page includes some of the most relevant resources for this class. But be sure to browse the shelves in the Reference Collection or ask your librarian for help finding more! Provides web access to 100 major Oxford University Press dictionaries, encyclopedias, and other reference works in the humanities, social sciences, foreign languages, science, technology and medicine, the performing arts, and religion. Works can be searched separately or across the entire databases. Includes over 1.5 million entries. 798 online reference resources from numerous publishers. This reference resource can be searched by individual title, broad subject headings, cross-references, audio and images. SAGE Knowledge 47 Sage Publication eReference titles representing many disciplines within the social sciences. These electronic encyclopedias cover topics such as juvenile justice, terrorism, social theory, crime, African American society, social welfare, education and many more themes. Subject Encyclopedias Online and in Print The library's collection includes a significant number of online electronic and print encyclopedias focused on Colonial America and the Atlantic World. The titles below represent a small selection of useful material, so please be sure to browse the shelves or use JumboSearch to find more! Call Number: eBook Encyclopedia chapter detailing how the circulation of people, goods, and ideas throughout the Atlantic Ocean during the early modern period created an Atlantic world that shaped the societies that developed on the four continents of the Atlantic rim. The Bloomsbury Encyclopedia of the American Enlightenment With over 500 original essays on key American Enlightenment figures, it provides a comprehensive account to complement the intense scholarly activity that has recently centered on the European Enlightenment. Encyclopedia of American Cultural and Intellectual History The Encyclopedia covers not only historic periods such as the Colonial era and the Reagan era, but also looks at cultural groups such as the working class and cultural institutions and forms such as the university and cinema. Encyclopedia of Emancipation and Abolition in the Transatlantic World Examines every effort to end slavery in the United States and the transatlantic world focusing on massive, broad-based movements, as well as specific incidents, events, and developments. The Oxford Companion to British History The Oxford Companion to British History covers all aspects of the history of Britain from 55 BC to the present day. The Princeton Companion to Atlantic History Call Number: D210 .P936 2015 This book, the first encyclopedic reference work on Atlantic history, takes an integrated, multicontinental approach that emphasizes the dynamics of change and the perspectives and motivations of the peoples who made it happen Oxford Bibliographies: Atlantic History This resource provides faculty and students alike with a seamless pathway to accurate and reliable resources for a variety of academic topics, including the history of the Atlantic world. Written and reviewed by academic experts, every article in this database offers an authoritative guide to the current scholarship, containing original commentary and annotations. Micah Saxton Subjects:English, History, Museum Studies, Race, Colonialism, & Diaspora, Religion Next: Articles on Your Topic >> Last Updated: Sep 16, 2020 12:09 PM URL: https://researchguides.library.tufts.edu/HIST193 Subjects: History Tags: course	cc/2021-04/en_middle_0036.json.gz/line1114
__label__wiki	0.734138	0.734138	Prevalence and service implications of health anxiety in genitourinary medicine clinics H Seivewright, Paul M Salkovskis, J Green, N Mullan, G Behr, E Carlin, S Young, D Goldmeier, P Tyrer A comparison of the prevalence of health anxiety in genitourinary medicine (GUM) clinics in two UK centres was carried out using a new rating scale, the Health Anxiety Inventory (HAI). The relationship of health anxiety to demographic and clinical variables, and its impact on service contacts, was also examined in one of these centres. 694 patients were assessed and significant health anxiety was identified in 8-11%. HAI scores were stable over time and high levels persisted in the absence of treatment. Attenders with sexually transmitted infections had significantly lower levels of health anxiety than those with other conditions. Contacts with clinic doctors and health advisors in the nine months before and after assessment were significantly greater in those with high health anxiety, with doctor appointments 37% higher in the high HAI group (P = 0.005). Health anxiety is a source of considerable morbidity in GUM clinics deserving further study. International Journal of STD & AIDS Fingerprint Dive into the research topics of 'Prevalence and service implications of health anxiety in genitourinary medicine clinics'. Together they form a unique fingerprint. Health Services Medicine & Life Sciences Sexually Transmitted Diseases Medicine & Life Sciences Health Status Medicine & Life Sciences Appointments and Schedules Medicine & Life Sciences Seivewright, H., Salkovskis, P. M., Green, J., Mullan, N., Behr, G., Carlin, E., Young, S., Goldmeier, D., & Tyrer, P. (2004). Prevalence and service implications of health anxiety in genitourinary medicine clinics. International Journal of STD & AIDS, 15(8), 519-522. https://doi.org/10.1258/0956462041558122 Prevalence and service implications of health anxiety in genitourinary medicine clinics. / Seivewright, H; Salkovskis, Paul M; Green, J; Mullan, N; Behr, G; Carlin, E; Young, S; Goldmeier, D; Tyrer, P. In: International Journal of STD & AIDS, Vol. 15, No. 8, 2004, p. 519-522. Seivewright, H, Salkovskis, PM, Green, J, Mullan, N, Behr, G, Carlin, E, Young, S, Goldmeier, D & Tyrer, P 2004, 'Prevalence and service implications of health anxiety in genitourinary medicine clinics', International Journal of STD & AIDS, vol. 15, no. 8, pp. 519-522. https://doi.org/10.1258/0956462041558122 Seivewright H, Salkovskis PM, Green J, Mullan N, Behr G, Carlin E et al. Prevalence and service implications of health anxiety in genitourinary medicine clinics. International Journal of STD & AIDS. 2004;15(8):519-522. https://doi.org/10.1258/0956462041558122 Seivewright, H ; Salkovskis, Paul M ; Green, J ; Mullan, N ; Behr, G ; Carlin, E ; Young, S ; Goldmeier, D ; Tyrer, P. / Prevalence and service implications of health anxiety in genitourinary medicine clinics. In: International Journal of STD & AIDS. 2004 ; Vol. 15, No. 8. pp. 519-522. @article{588029f76a124565bfd32a3e99e0b23d, title = "Prevalence and service implications of health anxiety in genitourinary medicine clinics", abstract = "A comparison of the prevalence of health anxiety in genitourinary medicine (GUM) clinics in two UK centres was carried out using a new rating scale, the Health Anxiety Inventory (HAI). The relationship of health anxiety to demographic and clinical variables, and its impact on service contacts, was also examined in one of these centres. 694 patients were assessed and significant health anxiety was identified in 8-11%. HAI scores were stable over time and high levels persisted in the absence of treatment. Attenders with sexually transmitted infections had significantly lower levels of health anxiety than those with other conditions. Contacts with clinic doctors and health advisors in the nine months before and after assessment were significantly greater in those with high health anxiety, with doctor appointments 37% higher in the high HAI group (P = 0.005). Health anxiety is a source of considerable morbidity in GUM clinics deserving further study.", author = "H Seivewright and Salkovskis, {Paul M} and J Green and N Mullan and G Behr and E Carlin and S Young and D Goldmeier and P Tyrer", journal = "International Journal of STD & AIDS", T1 - Prevalence and service implications of health anxiety in genitourinary medicine clinics AU - Seivewright, H AU - Salkovskis, Paul M AU - Green, J AU - Mullan, N AU - Behr, G AU - Carlin, E AU - Young, S AU - Goldmeier, D AU - Tyrer, P N2 - A comparison of the prevalence of health anxiety in genitourinary medicine (GUM) clinics in two UK centres was carried out using a new rating scale, the Health Anxiety Inventory (HAI). The relationship of health anxiety to demographic and clinical variables, and its impact on service contacts, was also examined in one of these centres. 694 patients were assessed and significant health anxiety was identified in 8-11%. HAI scores were stable over time and high levels persisted in the absence of treatment. Attenders with sexually transmitted infections had significantly lower levels of health anxiety than those with other conditions. Contacts with clinic doctors and health advisors in the nine months before and after assessment were significantly greater in those with high health anxiety, with doctor appointments 37% higher in the high HAI group (P = 0.005). Health anxiety is a source of considerable morbidity in GUM clinics deserving further study. AB - A comparison of the prevalence of health anxiety in genitourinary medicine (GUM) clinics in two UK centres was carried out using a new rating scale, the Health Anxiety Inventory (HAI). The relationship of health anxiety to demographic and clinical variables, and its impact on service contacts, was also examined in one of these centres. 694 patients were assessed and significant health anxiety was identified in 8-11%. HAI scores were stable over time and high levels persisted in the absence of treatment. Attenders with sexually transmitted infections had significantly lower levels of health anxiety than those with other conditions. Contacts with clinic doctors and health advisors in the nine months before and after assessment were significantly greater in those with high health anxiety, with doctor appointments 37% higher in the high HAI group (P = 0.005). Health anxiety is a source of considerable morbidity in GUM clinics deserving further study. UR - http://dx.doi.org/10.1258/0956462041558122 JO - International Journal of STD & AIDS JF - International Journal of STD & AIDS	cc/2021-04/en_middle_0036.json.gz/line1116
__label__wiki	0.902423	0.902423	How the Pandemic Could Change Retail Headquarters By Thad Rueter - 08/12/2020 Multiple HQ locations could serve to reduce the retailer’s carbon footprint, reflecting a broader trend. REI Co-op wants to redefine the corporate headquarters concept — a signal of how this year of the pandemic is changing the thinking of retailers. The seller of outdoor gear and apparel said Tuesday that it is trying to sell its newly completed corporate campus in the Spring District neighborhood of Bellevue, Washington. Instead, REI prefers what it calls a less centralized approach to its headquarters presence in the Seattle area. More specifically, REI plans to shift from a single headquarters to multiple locations spread across the region. Doing so could better enable remote working and allow more REI employees to live — and work — outside of the Puget Sound area. As well, multiple locations could serve to reduce the retailer’s carbon footprint — reflecting a larger trend in retail (including with Amazon) and no doubt giving REI more credibility among outdoor enthusiasts. Sustainability, already a hot trend before the pandemic, has gained significant energy as the outbreak forced retailers and customers to rethink the consumer, supply chain and work-from-home experiences. "The dramatic events of 2020 have challenged us to reexamine and rethink every aspect of our business and many of the assumptions of the past. That includes where and how we work," said REI President and CEO Eric Artz. "As a result, our new experience of 'headquarters' will be very different than the one we imagined more than four years ago." As the pandemic raged, the co-op transitioned to nearly 100 percent remote work for its headquarters staff in early March. REI originally announced plans for the new headquarters in 2016, to be built on an 8-acre site in a developing, transit-oriented neighborhood called the Spring District. Construction began in 2018 for an intended mid-summer 2020 move-in date. "[This year] we learned that the more distributed way of working we previously thought untenable will instead unlock incredible potential," said Artz. "This will have immediate, positive impacts on our ability to attract and retain a diverse and highly skilled workforce, as we continue to navigate the impacts of the COVID-19 pandemic and beyond." While the decision to move away from a traditional headquarters model was motivated by recent learnings and a desire to create more flexibility for employees, REI said, the sale would also have financial benefits for the co-op. The co-op was among the first retailers to proactively close all its retail stores in early March and one of the last to fully reopen, under stringent health and safety guidelines. The co-op undertook a number of cash preservation measures throughout the spring, including tighter inventory management, elective pay cuts by Artz and the board of directors, reductions in headcount and focusing around a streamlined set of priorities. These measures both stabilized the co-op, and allowed REI to invest in customer and staff-facing programs and innovations, as the co-op community adapted to a "new normal." The sale of the Spring District campus would enable important investments in customer innovations, REI's network of nonprofit partners, and the co-op's carbon goals. "I am confident that the sale of the Spring District campus would have a positive impact on REI's future—and yours," Artz told employees on Tuesday. "This year has shown us our home is not a building. Our home is wherever we find ourselves doing our best work, pursuing our outdoor passions, serving our communities. Serving each other. That is what we will build around as we move forward—and as we accelerate into what's next." Also Worth Reading Amazon's Arena Won't Be Called Amazon Arena Climate Pledge Arena will house NHL and WNBA games Tractor Supply Co. Raises Bar for Sustainability Retailers are paying more attention to environmental and diversity issues Target Expands Sustainability Efforts Will finance Summit Academy expansion in Minneapolis Kroger Debuts Private Label Recycling Program TerraCycle partnership a component of grocer's Zero Hunger \| Zero Waste plan Amazon Expands HQ Beyond Seattle It’s Not Just the Pandemic — Winter Weather Matters in 2020 Dick’s Sporting Goods Rides Online Wave to Q2 Gains Amazon Gets a Climate Boost from Uber, Others Kohl’s Puts Hopes in Active Wear and Omnichannel	cc/2021-04/en_middle_0036.json.gz/line1117
__label__cc	0.540346	0.459654	Tag Archives: score Close Encounters of the Third Kind: My Father’s Take Finally, here’s the long awaited post from my Dad for his Father’s Day present. Enjoy! On the surface, Close Encounters of the Third Kind, released in 1977, is a story of how three individuals’ lives become intertwined when some possible alien ship encounters are experienced. Roy, an electric company engineer in Indiana, has a growing need to understand if he is crazy or if he has really received a message from the aliens. Jillian, a single mother from the same area of Indiana and her three-year-old son have received the message too and the aliens have apparently taken a particular liking to the little boy. The final character is Frenchman Claude Lacombe who is part of an international team both reaching out to the aliens and investigating the people the aliens have affected. It would be easy to say I like Close Encounters because it is a Steven Spielberg movie. He both wrote and directed the film, and it was early on in his career when I feel he had a great child-like sense of wonder in his storytelling (E.T.: The Extra-Terrestrial, Raiders of the Lost Ark, Empire of the Sun). I also think he was enjoying his time saying, “I really get a big budget and get paid for having fun?” I could say I like the movie for the gifted John Williams score. I could discuss the symbolism of communication like languages (French, Spanish, Indian, English), physical interaction (radar, toys, sign), and art (music, painting, sculpture) to show that even humans have a hard time so why do we think the aliens could easily get their message across. I could say I like the 70s costumes – which weren’t costumes at the time but who would have put Teri Garr in a short yellow nighty and robe with earthy clogs – brilliant!! And I do think the special effects are good with the alien ships, the clouds, the lighting, the sandstorms, etc. I guess the problem I have is with the aliens. Why are there three different kinds of aliens so vastly different from each other? My favorite part of the movie is the hero portrayed by the everyman who has been tapped for an adventure – Roy Neary. Despite his obstacles – like his beautifully portrayed dysfunctional family, like everyone thinking he is crazy, like his own belief that he is on the edge of sanity – he faces his fears, does the right thing, and is rewarded in the end. Richard Dreyfuss, who had been acting at this point for over 10 years but hadn’t had a great deal of recognition except for his role of Curt in American Graffiti and Hooper in Stephen Spielberg’s Jaws, is fantastic in this role. He shows anger, wonder, insanity, happiness, and despair. He gets to be in the action sequences – driving in the chase, driving cross country, climbing the mountain; being interrogated by the “bad guys;” saving the girl. He deals with the mundane – his son’s math homework, kids that want to stay up late (watch for a great quote – “I told them they could only watch five commandments), a boss who doesn’t want to talk to him, and a wife who cares for him but can only take so much. And he does it all while trying to figure out his purpose in life. He gets the Oscar nod from me! So do yourself a favor, when you don’t feel the need for extreme action or extreme thought but want to play with your mashed potatoes, play in the dirt, and watch a great actor having a great time with a great script, get lost in the wonder of Close Encounters. It is better than Goofy Golf or Pinocchio. I give it a 9.9 out of 10! Leave a comment \| tags: 1977, 3 year old son, 70's costumes, alien ship, American Graffiti, art, bad guys, big budget, child-like sense of wonder, Claude Lacombe, Close Encounters of the Third Kind, clouds, communication with languages, cross country, Curt, dad, driving chase scene, dysfunctional family, Empire of the Sun, English, ET: The Extraterrestrial, face your fears, fantastic leading role, Father's Day, French, Frenchman, good special effects, Goofy Golf, great quotes, great script, guest blogger, having fun, Hero, Hooper, humans, Indian, Indiana, insanity, international alien investigation team, intertwining, Jaws, Jillian, John Williams, lightning, mashed potatoes, math homework, mountain, mundane scenes, music, Oscar worthy, painting sculpture, physical interaction, Pinocchio, play in the dirt, problem with the aliens, radar, Raiders of the Lost Ark, Richard Dreyfuss, Roy, Roy Neary, sandstorms, save the girl, score, sign, single mother, Spanish, Steven Spielburg film, symbolism, Teri Garr, the everyman, three individuals, toys, wrote and directed \| posted in Movies Gnomeo & Juliet This cute little film filled with British actors takes a new look at the story of Romeo and Juliet and uses a British topic of interest. Garden gnomes. (Not sure if a lo of Brits have these, but it’d be interesting to see some U.K. gardens.) I watched this with my mom (U.K. T.V. analyst and fellow blogger) mostly for James McAvoy’s voice talents. We’re both fans, but for slightly different reasons. (Not really though, he is pretty dreamy.) This tragic William Shakespeare story is turned on its head (as the poster suggests) with a cute plot device using warring gardens who happen to be owned by Miss Montague (Julie Walters, good old Mrs. Weasley) of the “Blue”burys and Mr. Capulet (Richard Wilson) of the “Red”bricks. Set apart from typical Pixar and Dreamworks films, this film takes its own approach to animation in the 3-D. Although McEvoy and Blunt as the disguised Gnomeo and Juliet Touchstone and Miramax do good animated films, this British touch to the way things looked was refreshing, at the same time that it seemed a bit off in its sharpness and cutting edge-i-ness. But it’s all the same to me these days, what with all these mass amounts of animal infested, fantastical adventures films made for kids and adults in 3-D animation. (I would recommend Rio though, it was quite a cast and story.) But the story stands out in comparison to the lack of pizzazz in the animation, and gave it some credibility. Warring gardens with love in the mix. So as expected, the story follows quite closely to the original Romeo and Juliet plot line. (Less death unfortunately.) The warring families led by Lord Rebrick (Michael Caine) who’s Juliet’s (Emily Blunt) father and Lady Bluebury (Maggie Smith) who’s Gnomeo’s (James McAvoy) mother despise each other for reasons that seem a bit hazy. The real test between the families is whose garden is superior. One night, in order to impress her father, Juliet sneaks out of the garden in order to retrieve a beautiful flower to spruce up the garden. Surprise, surprise, Gnomeo sneaks out as well for some mischief. The two cross paths, sparks fly, and their love is forever fated. But oh the problems that ensue. One’s red and the other’s blue! What will they do? Their love is forbidden and they may only meet in secrecy. And there must be some conflict that arises when their love is discovered! And yes, there is. This version doesn’t disappoint and how could it? True British actors are tackling a fellow countryman’s play. Now let’s talk about the cast. I was quite surprised at the acting chops associated with this film, and every last one a Brit! Of course there’s the two star-crossed Sorry Jim Cummings you just missed the mark. lovers, James McAvoy and Emily Blunt as Gnomeo and Juliet. Maggie Smith and Michael Caine lend their voices to their parents as some veterans of the BBC business. Also, and more unexpectedly, Jason Statham is featured in this film as Tybalt the red menace of the Montague house. I was really surprised to discover this after a few Transporter lines were delivered. I just can’t seem to grip the idea that Jason Statham is British! Matt Lucas, the good old Little Britains sketch comedy genius of the hairless kind lends a generically comedic voice to Benny, Gnomeo’s number 2. Even Patrick Stewart (Will Shakes himself) and OZZY OSBOURNE himself lends his voice to this film, as a ceramic fawn! Thanks to this British cast for the cute film! The only miss in this film is Jim Cummings as the pink flamingo garden ornament. His annoying attempt at some sort of foreign bird just loses it for me, because, to put it bluntly, didn’t deliver a funny line. This is quite disappointing as Jim Cummings has been in the Disney voice business since the early 90’s. But all in all, this cute film about what our gardens hold delivers a nice little escape from reality for 75 minutes. With the occasional grown up joke and slapstick comedy, mixed with witty uses of the gnomes and what they’d be like if they could move (Toy Story style), this movie delivers a bit of entertainment worth a watch if you’re into British accents or children’s love/comedy/adventure films. 6 out of 10. AND DID I MENTION THAT THE FILMED IS FUELED BY A ELTON JOHN SCORE AND SOUNDTRACK?!?!? Leave a comment \| tags: 3-D, adventure, animal, animation, BBC, Benny, bloggers, British actors, Brits, comedy, cute, Disney, Dreamworks, Elton John, Emily Blunt, fantastical, fawn, flower, forbidden love, foreign accent, garden gnomes, Gnomeo, James McAvoy, Jason Statham, Jim Cummings, Julie Walters, Juliet, Lady Bluebury, Lord Redbrick, love, Maggie Smith, mass amounts, Matt Lucas, Michael Caine, Miramax, Miss Montague, mom, Mr. Capulet, Mrs. Weasley, Ozzy Osbourne, Patrick Stewart, pink flamingo, Pixar, red vs blue, Richard Wilson, Rio, Romeo and Juliet, score, sketch comedy, slapstick, soundtrack, Touchstone, Toy Story, tragic, Transporter, TV, Tybalt, UK, voice actor, warring gardens, William Shakespeare, witty \| posted in Movies	cc/2021-04/en_middle_0036.json.gz/line1119
__label__wiki	0.650211	0.650211	GermanyUnited KingdomUnited StatesNetherlandsSwitzerlandCzechiaFranceBelgiumAustriaIranCanadaItalyPolandRussiaSpainJapanBrazilSwedenIrelandLuxembourgAustraliaChinaHungaryDenmarkPortugalIndiaNorwayUkraineThailandFinlandSlovakiaIsraelTurkeyGreeceHong KongSloveniaSouth KoreaCroatiaSingaporeUnited Arab EmiratesJerseyRomaniaIndonesiaMalaysiaSouth AfricaMexicoTaiwanArgentinaEgyptPhilippinesVietnamEstoniaNew ZealandColombiaSerbiaChileBulgariaSaudi ArabiaMaltaQatarLithuaniaLatviaIcelandPakistanEthiopiaVenezuelaCyprusKazakhstanMoroccoCosta RicaPeruNigeriaJordanKuwaitLiechtensteinSenegalTunisiaIraqKenyaAlgeriaBelarusBangladeshLebanonAlbaniaBahrainPuerto RicoEcuadorMoldovaSri LankaGuernseyMauritiusBosnia and HerzegovinaOmanUzbekistanDominican RepublicMacauNamibiaPanamaSudanParaguayAzerbaijanBurmaMaldivesUruguayMongoliaArmeniaReunionNorth MacedoniaCambodiaGhanaYemenTanzaniaJamaicaBoliviaLibyaNepalGeorgiaMontenegroUgandaGabonTrinidad and TobagoBarbadosHondurasRepublic of the CongoFaroe IslandsAngolaBruneiCuracaoCubaIsle of ManPalestinian TerritoryTogoGuatemalaAfghanistanCote d'IvoireMayotteNew CaledoniaGuadeloupeRwandaBermudaAndorraEl SalvadorTajikistanMartiniqueKyrgyzstanLaosMozambiqueSurinameCabo VerdeCameroonSyriaNicaraguaMonacoAntigua and BarbudaZimbabweKosovoBurundiPapua New GuineaThe GambiaGuamBurkina FasoDemocratic Republic of the CongoNorthern Mariana IslandsMadagascarMaliLiberiaBelizeSomaliaSaint LuciaLesothoGreenlandEquatorial GuineaSouth SudanFrench PolynesiaHaitiSeychellesFalkland IslandsBotswanaSaint MartinMauritaniaFijiSint MaartenDjiboutiBhutanZambiaVatican CityArubaMalawiAland IslandsThe Bahamas Northern Mariana Islands Population: 51,994 Under US administration as part of the UN Trust Territory of the Pacific, the people of the Northern Mariana Islands decided in the 1970s not to seek independence but instead to forge closer links with the US. Negotiations for territorial status began in 1972. A covenant to establish a commonwealth in political union with the US was approved in 1975, and came into force on 24 March 1976. A new government and constitution went into effect in 1978. Strategic location in the North Pacific Ocean Location: Oceania, islands in the North Pacific Ocean, about three-quarters of the way from Hawaii to the Philippines Area: total: 464 sq km land: 464 sq km note: consists of 14 islands including Saipan, Rota, and Tinian Size comparison: 2.5 times the size of Washington, DC Climate: tropical marine; moderated by northeast trade winds, little seasonal temperature variation; dry season December to June, rainy season July to October Terrain: the southern islands in this north-south trending archipelago are limestone, with fringing coral reefs; the northern islands are volcanic, with active volcanoes on several islands Natural resources: arable land, fish Irrigated land: 1 sq km (2012) Natural hazards: active volcanoes on Pagan and Agrihan; typhoons (especially August to November) Current Environment Issues: contamination of groundwater on Saipan may contribute to disease; clean-up of landfill; protection of endangered species conflicts with development Nationality: noun: n/a(US citizens) adjective: NA Ethnic groups: Asian 50% (includes Filipino 35.3%, Chinese 6.8%, Korean 4.2%, and other Asian 3.7%), Native Hawaiian or other Pacific Islander 34.9% (includes Chamorro 23.9%, Carolinian 4.6%, and other Native Hawaiian or Pacific Islander 6.4%), other 2.5%, two or more ethnicities or races 12.7% (2010 est.) Languages: Philippine languages 32.8%, Chamorro (official) 24.1%, English (official) 17%, other Pacific island languages 10.1%, Chinese 6.8%, other Asian languages 7.3%, other 1.9% (2010 est.) Religions: Christian (Roman Catholic majority, although traditional beliefs and taboos may still be found) Population: 51,994 (July 2018 est.) Age structure: 0-14 years: 26.17% (male 7,355 /female 6,252) 15-24 years: 15.71% (male 4,365 /female 3,804) 25-54 years: 39.14% (male 10,545 /female 9,805) 55-64 years: 13% (male 3,701 /female 3,057) 65 years and over: 5.98% (male 1,672 /female 1,438) (2018 est.) Net migration rate: -15.2 migrant(s)/1,000 population (2018 est.) Major urban areas - population: 51,000 SAIPAN (capital) (2018) Country name: conventional long form: Commonwealth of the Northern Mariana Islands conventional short form: Northern Mariana Islands former: Trust Territory of the Pacific Islands, Mariana Islands District abbreviation: CNMI etymology: formally claimed and named by Spain in 1667 in honor of the Spanish Queen, MARIANA of Austria Government type: presidential democracy; a commonwealth in political union with the US Capital: name: Saipan time difference: UTC+10 (15 hours ahead of Washington, DC, during Standard Time) Administrative divisions: none (commonwealth in political union with the US); there are no first-order administrative divisions as defined by the US Government, but there are 4 municipalities at the second order: Northern Islands, Rota, Saipan, Tinian Independence: none (commonwealth in political union with the US) National holiday: Commonwealth Day, 8 January (1978) Constitution: history: partially effective 9 January 1978 (Constitution of the Commonwealth of the Northern Mariana Islands); fully effective 4 November 1986 (Covenant Agreement) amendments: proposed by constitutional convention, by public petition, or by the Legislature; ratification of proposed amendments requires approval by voters at the next general election or special election; amendments proposed by constitutional convention or by petition become effective if approved by a majority of voters and at least two-thirds majority of voters in each of two senatorial districts; amendments proposed by the Legislature are effective if approved by majority vote; amended several times, last in 2012 (2017) Legal system: US system applies, except for customs and some aspects of taxation Suffrage: 18 years of age; universal; note - indigenous inhabitants are US citizens but do not vote in US presidential elections Executive branch: chief of state: President Donald J. TRUMP (since 20 January 2017); Vice President Michael R. PENCE (since 20 January 2017) head of government: Governor Ralph TORRES (since 29 December 2015); Lieutenant Governor Victor HOCOG (since 29 December 2015) cabinet: Cabinet appointed by the governor with the advice and consent of the Senate elections/appointments: president and vice president indirectly elected on the same ballot by an Electoral College of 'electors' chosen from each state; president and vice president serve a 4-year term (eligible for a second term); under the US Constitution, residents of the Northern Mariana Islands do not vote in elections for US president and vice president; however, they may vote in Democratic and Republican party presidential primary elections; governor directly elected by absolute majority vote in 2 rounds if needed; election last held on 13 November 2018 (next to be held in 2022) election results: Ralph TORRES elected governor; percent of vote - Ralph TORRES (Republican) 62.2%, Juan BABAUTA (Independent) 37.8%; Arnold PALACIOS elected Lieutenant Governor Legislative branch: description: bicameral Northern Marianas Commonwealth Legislature consists of: Senate (9 seats; members directly elected in single-seat constituencies by simple majority vote to serve 4-year terms) House of Representatives (20 seats; members directly elected in single-seat constituencies by simple majority vote to serve 2-year terms) the Northern Mariana Islands directly elects 1 delegate to the US House of Representatives by simple majority vote to serve a 2-year term elections: CNMI Senate - last held on 8 November 2016 (next to be held in November 2020) CNMI House of Representatives - last held on 13 November 2018 (next to be held in November 2020) Commonwealth of Northern Mariana Islands delegate to the US House of Representatives - last held on 13 November 2018 (next to be held in November 2020) election results: CNMI Senate - percent of vote by party - NA; seats by party - Republican Party 6, independent 3; composition - men 8, women 1, percent of women 11.1% CNMI House of Representatives - percent of vote by party - NA; seats by party - Republican Party 13, independent 7; composition - men 17, women 3, percent of women 15%; note - total CNMI Legislature percent of women 13.8% delegate to US House of Representatives - seat won by Democratic Party; composition - 1 man note: the Northern Mariana Islands delegate to the US House of Representatives can vote when serving on a committee and when the House meets as the "Committee of the Whole House" but not when legislation is submitted for a “full floor” House vote Judicial branch: highest courts: Supreme Court of the Commonwealth of the Northern Mariana Islands (CNMI) (consists of the chief justice and 2 associate justices); US Federal District Court (consists of 1 judge); note - US Federal District Court jurisdiction limited to US federal laws; appeals beyond the CNMI Supreme Court are referred to the US Supreme Court judge selection and term of office: CNMI Supreme Court judges appointed by the governor and confirmed by the CNMI Senate; judges appointed for 8-year terms and another term if directly elected in a popular election; US Federal District Court judges appointed by the US president and confirmed by the US Senate; judges appointed for renewable 10-year terms subordinate courts: Superior Court Political parties and leaders: Democratic Party [Daniel QUITUGUA] Republican Party [James ADA] International organization participation: PIF (observer), SPC, UPU National symbol(s): latte stone; national colors: blue, white National anthem: name: "Gi Talo Gi Halom Tasi" (In the Middle of the Sea) lyrics/music: Jose S. PANGELINAN [Chamoru], David PETER [Carolinian]/Wilhelm GANZHORN note: adopted 1996; the Carolinian version of the song is known as "Satil Matawal Pacifico;" as a commonwealth of the US, in addition to the local anthem, "The Star-Spangled Banner" is official (see United States) The economy of the Commonwealth of the Northern Mariana Islands(CNMI) has been on the rebound in the last few years, mainly on the strength of its tourism industry. In 2016, the CNMI’s real GDP increased 28.6% over the previous year, following two years of relatively rapid growth in 2014 and 2015. Chinese and Korean tourists have supplanted Japanese tourists in the last few years. The Commonwealth is making a concerted effort to broaden its tourism by extending casino gambling from the small Islands of Tinian and Rota to the main Island of Saipan, its political and commercial center. Investment is concentrated on hotels and casinos in Saipan, the CNMI’s largest island and home to about 90% of its population. Federal grants have also contributed to economic growth and stability. In 2016, federal grants amounted to $101.4 billion which made up 26% of the CNMI government’s total revenues. A small agriculture sector consists of cattle ranches and small farms producing coconuts, breadfruit, tomatoes, and melons. Legislation is pending in the US Congress to extend the transition period to allow foreign workers to work in the CNMI on temporary visas. GDP (purchasing power parity): $1.242 billion (2016 est.) $933 million (2015 est.) $845 million (2014 est.) note: GDP estimate includes US subsidy; data are in 2013 dollars GDP (official exchange rate): $1.242 billion (2016 est.) (2016 est.) GDP - real growth rate: 28.6% (2016 est.) 3.8% (2015 est.) 3.5% (2014 est.) GDP - per capita (PPP): $24,500 (2016 est.) $18,400 (2015 est.) $16,600 (2014 est.) GDP - composition, by end use: household consumption: 43.1% (2016 est.) government consumption: 28.9% (2016 est.) investment in fixed capital: 26.3% (2016 est.) investment in inventories: n/a (2016 est.) exports of goods and services: 73.6% (2016 est.) imports of goods and services: -71.9% (2016 est.) GDP - composition, by sector of origin: agriculture: 1.7% (2016) industry: 58.1% (2016 est.) services: 40.2% (2016) Agriculture - products: vegetables and melons, fruits and nuts; ornamental plants; livestock, poultry, eggs; fish and aquaculture products Industries: tourism, banking, construction, fishing, handicrafts, other services Industrial production growth rate: n/a Labor force: 27,970 (2010 est.) note: includes foreign workers Unemployment rate: 11.2% (2010 est.) 8% (2005 est.) Population below poverty line: n/a Budget: revenues: 389.6 million (2016 est.) expenditures: 344 million (2015 est.) Public debt: 7.1% of GDP (2017 est.) Exports: $914 million (2016 est.) $520 million (2015 est.) Exports - commodities: garments Imports: $893 million (2016 est.) $638 million (2015 est.) Imports - commodities: food, construction equipment and materials, petroleum products Debt - external: n/a Exchange rates: the US dollar is used Electricity - production: 60,600 kWh (2009) Electricity - consumption: 48,300 kWh (2009) Electricity - imports: 0 kWh (January 2009 est.) Telephone system: general assessment: digital fiber-optic cables and satellites connect the islands to worldwide networks; future launch of 5G (2018) domestic: wide variety of services available including dial-up and broadband Internet, mobile cellular, international private lines, payphones, phone cards, voicemail, and automatic call distribution systems (2018) international: country code - 1-670; satellite earth stations - 2 Intelsat (Pacific Ocean) Broadcast media: 1 TV broadcast station on Saipan; multi-channel cable TV services are available on Saipan; 9 licensed radio broadcast stations (2009) Internet country code: .mp Internet users: total: 16,000 Roadways: total 536 km Ports and terminals: major seaport(s): Saipan, Tinian, Rota Defense is the responsibility of the US Disputes - International: none GermanyUnited KingdomUnited StatesNetherlandsSwitzerlandCzechiaFranceBelgiumAustriaIranCanadaItalyPolandRussiaSpainJapanBrazilSwedenIrelandLuxembourgAustraliaChinaHungaryDenmarkPortugalIndiaNorwayUkraineThailandFinlandSlovakiaIsraelTurkeyGreeceHong KongSloveniaSouth KoreaCroatiaSingaporeUnited Arab EmiratesJerseyRomaniaIndonesiaMalaysiaSouth AfricaMexicoTaiwanArgentinaEgyptPhilippinesVietnamEstoniaNew ZealandColombiaSerbiaChileBulgariaSaudi ArabiaMaltaQatarLithuaniaLatviaIcelandPakistanEthiopiaVenezuelaCyprusKazakhstanMoroccoCosta RicaPeruNigeriaJordanKuwaitLiechtensteinSenegalTunisiaIraqKenyaAlgeriaBelarusBangladeshLebanonAlbaniaBahrainPuerto RicoEcuadorMoldovaSri LankaGuernseyMauritiusBosnia and HerzegovinaOmanUzbekistanDominican RepublicMacauNamibiaPanamaSudanParaguayAzerbaijanBurmaMaldivesUruguayMongoliaArmeniaReunionNorth MacedoniaCambodiaGhanaYemenTanzaniaJamaicaBoliviaLibyaNepalGeorgiaMontenegroUgandaGabonTrinidad and TobagoBarbadosHondurasRepublic of the CongoFaroe IslandsAngolaBruneiCuracaoCubaIsle of ManPalestinian TerritoryTogoGuatemalaAfghanistanCote d'IvoireMayotteNew CaledoniaGuadeloupeRwandaBermudaAndorraEl SalvadorTajikistanMartiniqueKyrgyzstanLaosMozambiqueSurinameCabo VerdeCameroonSyriaNicaraguaMonacoAntigua and BarbudaZimbabweKosovoBurundiPapua New GuineaThe GambiaGuamBurkina FasoDemocratic Republic of the CongoNorthern Mariana IslandsMadagascarMaliLiberiaBelizeSomaliaSaint LuciaLesothoGreenlandEquatorial GuineaSouth SudanFrench PolynesiaHaitiSeychellesFalkland IslandsBotswanaSaint MartinMauritaniaFijiSint MaartenDjiboutiBhutanZambiaVatican CityArubaMalawiAland IslandsThe Bahamas « Previous Country \| Next Country » Back to Flag Counter Overview	cc/2021-04/en_middle_0036.json.gz/line1127
__label__wiki	0.7044	0.7044	Set The Tape Independent pop culture entertainment site covering film, games, music, TV and more. © 2019 – Set The Tape. All Rights Reserved. Film discussion TV discussion TV Rewind Theatre & Events Brooklyn Horror Film Festival Cambridge Film Festival The Orville 2×07 – ‘Deflectors’ – Review By Lee Thacker 28 February 2019 27 February 2019 Leave a Comment on The Orville 2×07 – ‘Deflectors’ – Review “The galaxy is full of so many unhappy people. Why ignore something good?” The Orville has really come into its own this season, thanks in no small part to its focus on the personal relationships of the crew: Claire and Isaac, Kelly and Cassius, and Bortus and Klyden have all had their individual stories, showing the different aspects of being a couple. It’s the last two of these pairings which come to the fore in this week’s episode, as well as giving the newest crew member – Talla Keyali – a bittersweet romantic involvement of her own. A Moclan engineer boards the USS Orville to carry out an upgrade of the Deflector Screens, and ends up crossing paths with his ex, Bortus. However, he hides a dark and dangerous secret, which he needs to keep from any other Moclans – including Bortus and Klyden – as it could result in life imprisonment for him, and shame for his family. The Orville has used Moclan culture as a means of commenting upon many gender and sexuality issues, such as transgenderism, and this week’s focus is a clever twist on the sort of situation many LGBTQ people have faced in their lives – having to hide their true selves away, for fear of shame, prejudice, and reprisals. From previous stories, we know Moclans are predominantly an all-male species, with females seen as and aberration and inferior; any Moclans born female end up being surgically altered soon after birth. As a result, it’s seen as an abnormality for any Moclans to be attracted to females, from any race or culture. In fact, it’s such a serious matter for them that even the act of revealing your preference can end up ruining a Moclan’s life, as they face the severest penalties under the law. Locar (Kevin Daniels) is one such Moclan, and he risks everything to admit his attraction to Keyali (Jessica Szohr), despite what that may entail for him. READ MORE: Star Trek: Discovery 2×06 – ‘The Sounds of Thunder’ – Review Star Trek rarely ventures into this sort of area (at least, not as directly); the closest it has really gotten to approaching it would be in The Next Generation episode ‘The Outcast’, where Riker falls for a member of an androgynous race that’s forbidden to have a defined gender identity, nor any sexual encounters, as these are all seen as being perversions; any offenders end up undergoing a treatment that’s effectively a form of brainwashing, in order to make them conform again to the norms of their society. It was a love story against all the odds, one which was almost inevitably set to end up with an unhappy outcome. The Orville proudly takes the baton from TNG and runs with it, showing how much we’ve developed as a society over the last 20 years, as a very similar story can now be told in a far more direct fashion. TNG‘s main failing in its attempt was not being bold enough by casting an actress in the role of Riker’s love interest – it would have been a brave move to cast a male in that role, but perhaps it would have been just a step too far at that time. Since then, we are far more familiar with seeing LGBTQ couples on our TVs than we perhaps were at that time, so The Orville has a perfect to tell that story now, using a same-sex race as being the convention, and using heterosexuality (or bisexuality) as being the thing to be feared and shunned. It’s the sort of story sci-fi does best – making us think about contemporary societal issues, by showing them to us through a prism. It’s a very layered story, as we are led to believe Moclans will turn in anyone who they suspect of being different in that way and make sure they face justice. Bortus’ husband Klyden (Chad L. Coleman) finds out about Locar’s interest in Keyali, and confronts him about it. However, when the truth comes out and Keyali confronts Bortus (Peter Macon) about the situation, he admits he already knew about Locar’s attraction to females all the way back to when they were a couple. We know that Bortus already has a complex history in that area, as Klyden was born a female, and he’d also had to go through his own child having forcible gender assignment surgery, so it was a logical progression to find that Bortus kept Locar’s secret out of love for him, as Bortus didn’t want to see him destroyed by the revelation coming out. Things take a very dark turn when Locar vanishes, and all the available evidence points toward Klyden being a murderer. However, as the Chief of Security, Keyali thinks that it’s all too convenient – even though Klyden had the means and the motivation, as well as a prior history of violence on the ship, after his near-fatal stabbing of Bortus as part of a Moclan divorce ceremony in the episode ‘Primal Urges’. Keyali soon realises that Locar has used his technical expertise to fake his own death, and frame Klyden, so that he can escape retribution for his sexuality at the hands of the Moclans. Having only recently joined the show, we haven’t yet had an episode highlighting Keyali, so this was her time to shine. As nice as it was to see her character given more depth and vulnerability, rather than just being a hard nut badass type, it does feel as though the storyline was originally crafted for the original Chief of Security, Alara Kitan – she was famously unlucky in love, and always bemoaning the fact she was bad at relationships, so this seems as though it was very much her episode, and you can’t quite escape the impression that the scripts had Alara’s name scribbled out rather hastily, and Keyali’s penned in. But that’s overall a minor concern in what is an incredibly strong and powerful story. The real tragedy is seeing that there’s no happy ending possible here – if Keyali lets Locar get away through her own personal feelings for him, she’s in dereliction of the duty she takes so very seriously; however, if she does her job properly, then she will be condemning Locar to ruination, and a life in prison, simply for a crime of loving the wrong person. On first viewing, the ending of the episode feels unsatisying, as you see a distraught and conflicted Keyali intercut with scenes of Locar being put on trial and sentenced back on Moclus. On a second viewing, however, it’s far easier to see this was, in fact, the only appropriate conclusion – a trite, pat resolution would have been totally the wrong take, and we need to see for ourselves the full tragedy of the situation unfolding, in order to be able to fully appreciate the true injustice, as well as the impossible position Keyali found herself in. READ MORE: Charmed 1×07 – ‘Out of Scythe’ – Review While all this has been going on, we also have Kelly (Adrianne Palicki) and Cassius’ (Chris Johnson) relationship crumbling, as he starts putting pressure on her to take things to the next level, and even talks of marriage and family. It’s clear the writers are strongly pitching for Kelly and Ed (Seth MacFarlane) to get back together, and this was an inevitable step in that process. You can also tell just how much careful thought and attention is put into every aspect of the show, as the episode’s title – ‘Deflectors’ – refers to far more than just the upgrade of the Orville’s shields; in Kelly’s case, it’s her attempt to deflect any attempts by Cassius to get her to commit more fully. For Locar, it’s his efforts to try and deflect any attention away from his sexuality. Given that this is generally a very intense and serious episode, it’s good to see The Orville has managed to master balancing out drama with comedy, as we still get a few lighter moments, which don’t detract from the main storyline in any way, and provide some welcome respite. One of these stems from Cassius’ attempts to win Kelly back after she ends things with him, and ends up sending a Katrudian (a giant sentient alien flower) to her quarters – the real unexpected kicker here is finding out that the voice is actually provided by an uncredited (moonlighting?) Bruce Willis. A lovely little touch, and one which adds something extra to the episode when you learn that it’s him. I don’t usually struggle with reviews, but I have with ‘Deflectors’ – not because there isn’t anything good to say about it (unlike some shows – Curfew, I’m looking at you), but because there’s just so much. In fact, it made me want to do justice to what was a pretty phenomenal piece of television. It demonstrates just how far The Orville has come, and is now compelling regular viewing in its own right, rather than just being a comedy Star Trek. The season is nearly over, sadly, but on this basis, they should easily knock it out of the park for the rest of its current run. The Orville airs weekly in the UK. Tags: Seth MacFarlane The Orville Published by Lee Thacker View all posts by Lee Thacker Set The Tape is an independent pop culture website with insightful reviews, fascinating opinions and fun lists all about film, TV, comics, music and games. Contact us at info@setthetape.com Joint Security Area (2000) - Blu-ray Review Inner Sanctum Mysteries (1943-45) - Blu-ray Review Subscribe to our mailing list to be notified about each new post. Previous Entry Mayans M.C. 1×08 – ‘Rata/Ch’o’ – Review Next Entry Some Nerve: Social Media and Modern Cinematic Voyeurism Competition Ts&Cs	cc/2021-04/en_middle_0036.json.gz/line1136
__label__wiki	0.919389	0.919389	After record snowfall, Madrid confronts mammoth garbage heaps Heavy snowfall in Madrid MADRID (Reuters) - Heaps of plastic rubbish bags were piled up alongside snowdrifts in downtown Madrid on Wednesday after a historic storm paralysed the city's infrastructure, leaving some 9,000 tonnes of uncollected waste lining its streets. Waste collection, which was suspended last Friday, restarted on Tuesday and had reached 40% capacity by that evening, the city council said in a statement. But discontent at the council's handling of the storm is rising, especially in the outskirts, according to the FRAVM federation of residents' associations. "Many of their streets remain blocked, there is no public transport and they (residents) are suffering a lack of supplies," the group tweeted alongside pictures of stranded cars, heaps of trash and an ambulance crew struggling to dig out their vehicle. Just 15% of roads in the Spanish capital had been cleared of snow and ice by Wednesday afternoon, three days after Storm Filomena crashed through central Spain, bringing record low temperatures and cutting off transport links. Schools, universities and nurseries will remain closed until at least Monday. Some cars were circulating slowly on avenues in the centre, but many smaller streets remain blocked by downed trees or treacherous ice patches. As the cleanup continues, politicians are struggling to count the cost of the damage wrought by the storm. "Madrid will receive a large bill from Filomena, one that reaches beyond several hundred million euros for sure," Madrid Mayor Jose Luis Martinez-Almeida told COPE radio station, adding that the hospitality sector alone had taken a 70 million euro hit. After some 150,000 trees were downed by the storm, Almeida said his administration would shortly put out a 15 million euro contract to assess the status of those that remain standing. (Reporting by Belén Carreño and Emma Pinedo, Writing by Nathan Allen,; Editing by Andrei Khalip and Angus MacSwan)	cc/2021-04/en_middle_0036.json.gz/line1137
__label__cc	0.700409	0.299591	Scott B. Pruden Freelance Writer, Voice Actor, Author Write On Time LLC Novel Pursuits The Triumphant Return of Funky Friday Well, hi! Yeah, it’s been a while since I’ve paid everyone a visit from Blogland, but hey … life. Lots is the same (still hacking away at novel No. 2, still doing the freelance thing for multiple happy clients) but some things are different (the addition of voice over to my ever-growing list of professional skills – more on that some other time). But one thing does and always shall remain the same – my ongoing search for new R&B, soul and funk that meets my personal criteria for awesomeness. And on that note, ladies and gentlemen, I present the latest single from the lovely Ms. Janelle Monae, “Make Me Feel.” It’s probably a disservice to file Ms. Monae into the slot of “Prince protege,” but it is true that she was working on her latest album with the Purple One before his tragic death in 2016 and that he hand given her a helping hand here and there in the early parts of her career. Prince being the prolific songwriter that he was, it’s suspected by many that somewhere in the vaults of Paisley Park Studios, there sits a cache of material of such gobsmacking quality that we mere mortals couldn’t even conceive of it. That’s borne out by Monae’s new song, which is a Prince original composition that he gifted to the singer from that very vault. Honestly, the fact that such a collection of quality songs exists otherwise untapped to this day is one of the great tragedies of the 21st Century, but I digress. Let’s instead be glad that Monae – and the rest of us, by extention – was the beneficiary of one of his last bits of open generosity. The song itself reads like a master class on what both Monae and Prince bring to the table – playful, hip-grinding pan-sexuality; lyrical fun; sonic surprises (the tongue clucks that set up the initial beat, for instance). The video, meanwhile, is like one long shout-out to Prince, referencing multiple looks he sported during his too-short career. Let’s count ’em off: The glasses Janelle wears as the “performer” in the club Her dancers Her see-through pants Her jewel mail veil-clad guitarist The interplay between the female friend with whom she arrives at the club and the male friend she meets there (“Who should I take home, her or him? Let’s make it both!”) Honestly, it’s almost like seeing something amazing in your kids that you once only associated with a beloved relative who’s since left this mortal coil. Our dear Janelle pays an incredible tribute to someone who served as a mentor for her and as a guide down the path of funk, soul, rock and pop for the rest of us, and it’s frankly wonderful to see. Grab Hold of the Week Like That Ex Who Just Wouldn’t Let Go Something about spring, the more agreeable weather and the additional daylight gets me back on the motivation train. The last few weeks have been marked by significant progress on the new novel, Mystery White Boy, and a couple of great events where people responded well to work both old and new. But Monday’s are still hard for most of us, particularly as the weather grows better. Because you’re able to jam more fun into the weekend, the hangover seems extra severe when 7 a.m. on the first workday of the week rolls around. So what better to get you going than a healthy dose of good, solid rock. Continue reading → Grab Hold of the Week Like That Ex Who Just Wouldn’t Let Go Will “Johnny B. Goode” Save Planet Earth? As we mourn Chuck Berry’s passing, it’s important to remember that without him, what we now know as rock n’ roll would have died in its infancy. Without him, the Beatles wouldn’t have become inspired, the Rolling Stones never would have met, and the Beach Boys would be minus a complete template into which they plugged “Surfin’ USA.” He’s the thread that connects them all. They (and probably a hundred other bands we never heard of) played his songs, learned his style, borrowed (stole) his licks, then passed those guitar riffs down to punk. There’s as much Chuck Berry in a Ramones song as there was in the British Invasion. His work courses through space, beyond our own solar system, aboard the Voyager space probe. If we’re lucky, as SNL suggested years ago, we may one day be viewed more kindly by some alien race for they having stumbled upon that now-archaic golden LP and its copy of “Johnny B. Goode.” Based on the current state of the world – and particularly the United States – that single song might be all that saves us. Power Pop to Help You Power Through, Good People Well, I don’t know about you, but around these parts it’s been kind of a rough week. I won’t go into the particulars, because what’s done is done, but I will suggest that now is the time, if you’ve been feeling a little down, to re-motivate yourself in a positive direction. None of you will be surprised that the way I try to lift my spirits is through music. And while you might have felt more mournful than celebratory over the last seven days, I would suggest that it’s time for the mourning period to be over. Quit your bitchin’ and get to work. Continue reading → Power Pop to Help You Power Through, Good People Funky Friday: Sonny Knight and the Lakers Make New Sound Old I’ve often joked that if I managed to make it to Heaven, I’d want my own horn section whose job would be to follow me around and punctuate my conversation with James Brown-style R&B call-and-response awesomeness. More realistically, I’m constantly on the lookout for new bands that reach back to that classic soul sound and drag it (sometimes kicking and screaming) into the 21st century. Some bands try, succeed a little, then peter out (I’m looking at you, Red Hot Chili Peppers), while others, like Sonny Knight and the Lakers, do right by the Godfather of Soul. Continue reading → Funky Friday: Sonny Knight and the Lakers Make New Sound Old Power Pop Wednesday: A Machine Just Released a Manufactured ‘Beatles’ Song Like most Beatles fans, there was a time when we hoped the band would somehow reunite for just one last show. That hope took a nosedive first with the shooting death of John Lennon, then George Harrison’s death from cancer. Along the way, we got a few tidbits, including a new song by the surviving members (Harrison, Ringo Starr and Paul McCartney) remixed with archival recordings of John Lennon for a best-of collection back in the 1990s. Honestly, that was just a little creepy – basically the three survivors discovering ghost tracks on an old reel, writing a little music around it and deciding to send it out into the world anyway. Granted, Paul in concert does a pretty good job of echoing the Beatles experience (at least the parts of it on which he sang lead), and he’s even teamed up with Ringo for TV performances here and there. Still, the experience of having the lads back together is one we’ll now have to just imagine. Continue reading → Power Pop Wednesday: A Machine Just Released a Manufactured ‘Beatles’ Song Returning from That Summer Place It’s almost back to school time here in southeastern Pennsylvania, which means the kids will be terminating their summer brain dumps, rushing to catch up on assigned reading and trying to remember how to convert improper fractions to mixed numbers. That usually means time for the grownups to start getting their acts together, too. I admit that I’ve slacked off this summer in a few areas – writing every day being one of the biggest. But where spring has always been the traditional time of renewal for nature, back to school time is, for kids and adults, typically the start of something fresh. It’s an opportunity to establish new routines and actually stick to them because so many other scheduled events depend on things running smoothly. Yeah, this summer my word count for Novel #2 has fallen off, but I’ve also gotten the chance to do some things that will help make that book better even though I’ve spent a few weeks not actively banging away at it. One of those weeks was spent at our family’s own summer place, this one deviating from past years by switching the Outer Banks of North Carolina for Folly Beach, S.C. New places equal new inspiration, so in lots of respects it was a worthwhile trip. I’m hoping it ends up as a salable travel story for the freelance writing side of my work, and there are always little details I can pick up from somewhere new to add into a story. Plus, as someone who sets his books in South Carolina but is based full time in Pennsylvania, it’s good to get back once in a while and get in touch with the people you’re writing about. It’s also been good to go down some roads in my own reading that I don’t often travel. I tilted more toward the fantasy side of things with Fran Wilde’s Updraft and delved into the world of the Mafia – particularly as it relates to Philadelphia and Wilmington, Del. – in Charles Brandt’s I Heard You Paint Houses (look for an upcoming story on Charles and the forthcoming film version of his book in September’s Out & About magazine). Novel #2 includes more of a criminal enterprise subplot, so it was great to read Brandt’s book and get a window into mob life beyond that provided in the Mafia film pantheon of The Godfather, Goodfellas, etc. And it’s always interesting to see what styles other writers adapt. Wilde’s is lean and tight, which keeps her sprawling, world-building tale to a reasonable and accessible length. While I’m not creating new universes out of whole cloth this time around, I’m trying to keep things leaner myself, so reading other writers who can do so is a bit like taking a master class in how it’s done. So, here’s to parlaying my non-writing experiences and unassigned summer reading into some good, solid work on Novel #2 once everyone in the house gets back to their school year schedules. It might not be lounging on the beach or by the pool, but there will be plenty of that again next year. Pre-Father’s Day Funky Friday: Papa Don’t Take No Mess Scattered across the Interwebs you’ll see a profusion of lame nostalgia from folks who maintain that their childhoods were the most idyllic and utterly perfect because of our borderline neglectful parents, helmetless Big Wheel obstacle courses, afternoons binging on ’60s TV sitcom reruns, hours of Atari and gallons of fully sugared Kool-Aid. I decline to wax rhapsodic about days past because nostalgia gets us absolutely nowhere as human beings. Nothing was ever as good as you remember it, and the examples people so enthusiastically offer up as “better times” are just the highlights they remember fondly. Mixed in with those amazing examples of freedom and adventure were those days where we said, “I’m bored” one too many times and our moms just locked us out of the house. Continue reading → Pre-Father’s Day Funky Friday: Papa Don’t Take No Mess May Your Monday Be Neato, Boss and Groovy A little secret – I get all my best dance moves from Wednesday Addams, who apparently got all her dance moves from James Brown. Evidence here: Holy Sht! OKGo Releases Video Shot in Zero-G It’s only been posted for a few hours, but take three minutes and eight seconds out of your day to view this new morsel of awesomeness from the power pop masterminds OKGo. The new video is for the song “Upside Down & Inside Out” from their latest album, Hungry Ghosts. Continue reading → Holy Sht! OKGo Releases Video Shot in Zero-G Animation Art Book Review Books Business Codorus Press Commentary Cool Images Fantasy Fiction Film Freelance Fun holiday Immaculate Deception Independent Publishing Inspiration Journalism Motivation Movies Music Nonfiction Politics Radio Science Fiction Scott B. Pruden Television Uncategorized video Writing	cc/2021-04/en_middle_0036.json.gz/line1151
__label__wiki	0.694846	0.694846	31 Burst results for "David Rankin" Dallas Police Chief Resigns in Wake of Policing Protests "The chief resigns, and now there are three countem three openings. This is the care of the afternoon news with Kristen Diaz. I'm David Rankin. Now that the Dallas Police chief Rene Hall announced her resignation, the three biggest cities in North Texas all have openings openings at at the the top top of of their their police police department's department's Dallas Dallas Fort Fort Worth Worth and and Arlington Arlington are are all all looking looking to to find find their their next next police police chief. chief. Sandy Sandy Harvey, Harvey, is is the the chief chief of of police police in in the the South South Texas Texas city city of of far far and says it's been tough being a police officer. Much less a chief over the past few years. I think what happened is that those lines, those mutual expectations, Uh, those lines are blurred now, so it's tough to do your job. When you don't know what that job is sometimes anymore, Arlington Mayor Jeff Williams says they've had over 70 applicants for the job in their city as to what they're looking for their next chief. We don't need to get locked into predetermined ideas because we've got to find the best candidate possible. It's a hard job being a police chief in any community, he says. There's Dallas Police Sandy Sandy Harvey Arlington Arlington Kristen Diaz Arlington Dallas David Rankin Rene Hall Texas North Texas Jeff Williams Officer NewsRadio 1080 KRLD "david rankin" Discussed on NewsRadio 1080 KRLD "With David Rankin, We're lining the Mercedes Benz Plano New Center, and you can stay connected to Karol. Get breaking news alerts right on your phone, download the radio dot com app. Happen the heart to favorite K R L D you know, in fighting the spread of Koven, 19 social distancing matters most. And that's the new finding in research, led by Dr David Rubin, director of the policy lab at the Children's Hospital of Philadelphia. He spoke with Carol These Mitch car? Yeah, we've message masks, which I think could be an important barrier. But you know, we've almost done it to the detriment of talking about distancing about limiting the size of your gatherings. If distance is the key. How much distance are we talking about? That comes from the knowledge of how a lot of our respiratory viruses spread, particularly rest trans, larger respiratory droplets. I know there's been some Data suggests that the crown of ours the stars Kobe to virus that's involved here can harass allies to be in the air for hours. But in actuality, the attack rate within households mirrors what we see with other common respiratory viruses. Where most of those respiratory droplets will will drop to the ground within six feet of the individual If they call, And what about the schools? Many classrooms don't have the size two separate kids by six feet. That's why it was so important to try to get our positivity rates down extremely low, so that the likelihood you know as school district way these tradeoff likely that there would be a super spreader event within a school. Would go down. But, you know, putting kids three feet apart, impact into a classroom with a positivity rate of 15% or whatever it is there right now, or 10 15%. Is just going to fail to me. The secret for these schools. These urban districts was we needed to really be great case counts in some areas of Texas. We've seen some hints of that in Waco and in in Austin, and I'm looking for a model this week. Then what kind of strategies can an urban school district? Think about 11 testing positive. The rates are low. And if you still want to get the kids back in school and the teachers and you can't do the six feet, what are the options? Well, you can add plexiglass between the teacher and the kids that you know, assuming he or she is wearing a mask as well to like, Teach for America has got a big history down there in Texas. And there are other programs like you up using paid substitutes that might be called college grads don't have jobs right now to assist teacher older teachers in the classroom because you know they have to feel safe in order to get them back to school. The reality is it's got to be some confidence of safety. And so if you can't do the 16 that's gonna road confidence in your teaching staff, they could go back to school safely. If you substitute that with volunteers allow them to have greater physical distance or even teach online into the room with teaching assistant knowing there are things you can do to provide that confidence to parents to teachers that you're trying to mitigate some of the classroom. Now, Ruben says a major factor in reopening schools is getting the virus positivity rates down around 5% not the 10 to 20% we've been seeing here in Texas ports in the news for Weather Brothers roofing. There's a number of downsides to working from home that employees have discovered during the pandemic. This site from one poll finds half of workers say the work life balance is now imbalanced. It's a working from home makes it harder for them to separate their work time from their family time. 20% say they actually miss their commute to and from the office. Normally, a commute gives them time to mentally prepare to go to work or come down from a busy day at the office after work. 15% say it's not all that convenient to have their offices only a few feet from their bedrooms. Almost half say they just missed the chance to see and talk to the coworkers. Everyday. People in Arlington are in need of food, and they're asking for donations. We have the details in the story after traffic and weather together on the eights 1 80/1 11 and I had a stroke. I couldn't speak walk. This is high blood pressure. Get back on your plan. Gotta lower your HBP dot org's brought to you by the American. Texas Carol Dr David Rubin Mercedes Benz Plano New Center urban school district David Rankin Koven Children's Hospital of Philade Karol director teaching assistant Arlington Weather Brothers Waco Ruben America Austin KRLD Sunday Morning News Need some good news about Covid-19? "Been been mostly mostly bad bad when when it it comes comes to to information information about about the the Corona Corona virus. virus. Harvard professor Joseph Allen at Harvard University's Th Chan's School of Public Health. Talk to Carol. These David Rankin and says there is some good news that therapeutic will be vaccine. So people may have heard of the steroid DEC. Method Stone on the antiviral disappear. These are being used to treat patients who are quite sick with Kobe 19. But there are other therapeutics that should be coming on the market, including what we call monoclonal antibodies. Normally when your body has a response to this virus of others that creates antibodies. Well, lot of clonal antibodies are just engineered and a body and they could be used for both prevention and treatment that the data they're looking really promising. On the testing front. We've seen advancement in terms of rapid saliva tests. You could think of these as a home pregnancy test. But for covert 19 and in this case is a strip of paper you put in your mouth and it gives you a test result pretty quickly, and it's cheap. And so while the test isn't perfect, the fact that it's cheap and you can take it back and at home. Even better than a better a good, accurate test, but takes seven days to get the results back. We keep seeing that these rapid tests are not as accurate does that increase the danger a little bit of if you think you are negative, and it comes up positive, it's a false positive or a false negative, really good question and the work that shows that if you get these rapid test that air cheap enough, not the expensive, rapid test. But that even if they have false negatives, the fact that you're taking them every day or even multiple times a day is better than an accurate test that you take. And then seven days later, you find out the result at which point it's too late. That you here is that even on day one. If it doesn't get it, then you catch it. The next time you took the test and worst case, you catch it on the third day, And if everybody starts doing this overall, it would really help too slow. The spread of disease, and we get a lot of people confidence about going back into stores or restaurants or even theaters. When is there going to be a vaccine? Because the vaccine seems to be the turning point whether or not we can get back to normal request. It wasn't that long ago where we weren't quite sure we could produce the vaccine for this Corona virus. On If we produce it within a year, which it looks like we'll be able to do that will be the fastest. A vaccine has never been produced by several years. But this is a remarkable scientific achievement. It looks like we will have a vaccine by the end of this year. But I want to be a caveat that that the real challenge is not just getting the vaccine. It's the distribution. Right vaccine never saved any lives on Ly a vaccination has we actually have to get the people? That's not to say it's really good news. I also think that news on therapeutic is just as important. Therapeutics will beat out vaccine this fall is what I'm seeing in terms of the science, and I think that's really important because people aren't scared of getting sick. There's getting scared of death. On. If you have therapeutic that can keep people that can prevent the worst outcomes. I think that will also helped give them confidence to people that will get through this okay. Professor Joseph Allen at Harvard's Th Chan School of Public Health. The U. Harvard University Professor Joseph Allen School Of Public Health David Rankin Th Chan School Of Public Healt Carol Professor Kobe Stone LY "As in David Rankin. The search is over for a man who opened fire at the home of Federal Judge Esther Solace. Police say the shooter turned up dead by his own hand. Sallis has been a federal judge since 2011. She has presided over a few high profile cases in recent years, including a number of gang violence cases and a financial fraud case involving Theresa Judy J. From the Real Housewives of New Jersey and her husband. Investigators say there is no evidence That these cases or anything involving Mark Andrew have anything to do with the shooting. That's Naomi Rockem reporting from New Jersey to November general elections air just over 100 days away, and state and local election officials are looking for more than just a few good men and women. State and local election officials across America are trying to recruit younger workers to staff polling places on election Day, November 3rd, the efforts driven by concern that many traditional poll workers will be too worried about catching the Corona virus to show Up. You see About 2/3 of poll workers across the US are over the age of 60. That age group is at a higher risk of catching covert 19 some states trying to partner with professional in fraternal organizations. The state of Ohio, for example, is recruiting high school students and some groups are trying to harness the youth energy from the recent racial justice protests. That's something that will need to be done to staff, the Poles and the very important November election. Scott Sam's news radio. 10 80 k. R. L D Delph says travelers that want to fly with him. Oh, and don't want to wear a mask. I have to go through a medical screening before they're allowed on the plane. Delta says passengers who can't wear a mask because of health conditions are encouraged to reconsider their entire travel. Otherwise, they'll be required to go throughout virtual exam that could take an hour. Delt also says people are allowed to wear plastic face shields in addition to masks, but not instead of It's a turtle, but it doesn't actually look like one. It looks more like 11 that a reptile and video is now going viral. A rare yellow turtle was spotted in India over the weekend, and the unusual creature is mesmerizing People around the world. The turtle was handed over to forest officials. Wildlife experts say it's possibly an albino mutation of a common journal. It's rare, but it can affect many different animals and occurs when there's little or no production of pigment in the skin, eyes and hair or in other species, the fur feathers or scales. That Piper CBS News More people choose to learn new things through how to videos on YouTube. Compared to any other method of learning. A new study finds 90% say they like to learn through videos because they can keep her winding them till they get a skill just right. Some of the more popular life hacks include How to play guitar. How to fold bed sheets and how to remove stains from clothing. 2/3 say they prefer videos, as opposed to getting help from someone they know. Others look to videos to figure out howto. Tough text. Tough sections on computer gains Most popular D I y projects putting up shelves Way wiring, a plugger fixing a dishwasher. New Jersey Sallis Delt Esther Solace Scott Sam David Rankin Naomi Rockem US R. L D Delph Ohio Mark Andrew partner Delta CBS Theresa Judy J. America fraud YouTube India "On your trip today to Denton I'm Julie Rogers next reported five thirty eight and breaking traffic alerts when they happen news traffic well a couple of showers are not out of the question anything that pops up will be isolated on NBC five chief meteorologist Rick Mitchell not only could we see a stray shower or thunderstorm tonight but perhaps into early Saturday morning and then once we get past about nine or ten the rest of the weekend looks dry of the forecast low temperature tonight about sixty four up to seventy five two more with a good deal of afternoon sunshine Sunday looks pretty nice mostly sunny high of seventy five and then Monday does not look all that pleasant it'll be much cooler with widespread rain a high of sixty seven sunshine does return for Tuesday and Wednesday with highs back in the lower seventies and it's currently eighty one degrees here at K. R. LD news traffic and weather all news all day news radio ten eighty KRLD your news now the bill is signed good afternoon it's five thirty on the care of the afternoon news thank you so much for staying with us I'm David Rankin with Kristen B. as the president signs that economic recovery package the president marveled at the size of the two point two trillion dollar package class workers lawmakers in both parties see this is just the start of the recovery effort Steven Portnoy a CBS news Washington the president also issues out in. Denton Julie Rogers NBC Rick Mitchell David Rankin Kristen B. president Steven Portnoy Washington chief meteorologist K. R. LD CBS "David Rankin live in the Mercedes Benz of Plano new center and now you can pause and rewind live radio just download the radio dot com app search for K. R. L. do you want to do and then click on the heart to favorite us neighbors are worried about the possibility that dart may want to take more properties for construction of its Silverline construction crews started work on that rail line in September but the design is not quite yet finished and B. C. fives can count off that says dar an ounce more changes this week through north Dallas this track were no trains are running at the moment runs right beside homes including one owned by Dane Coles for he assembled a set of maps to study the proposed rail line and keep track of what dart said about it through the years of planning now that it is definitely going forward he and other neighbors are even more concerned about the details the technology will be like the fort worth tex rail trains not starts electric train changes this week were to address neighbor concerns about the last design the call for elevated train tracks but the land dar will ask for has not been identified there is entirely the possibility that they could come along and say well we just want to slice it in half or with office corner we just want all it may be the last fifteen people there right now seventy two properties that we've identified that the bulk of those ones over fifty five of them are actually partials which are small slivers of lands of what's on the corner someone's property so that's still as. David Rankin Benz K. R. L. Dallas Dane Coles dart Plano Silverline tex rail Seven killed at shooting on Milwaukee campus: report "It is three fifty I'm David Rankin with Kristen D. as the latest now that shooting in Milwaukee CBS news reporting five people killed at the Miller Coors brewing campus sources say that five people died including the shooter it happens inside the brewery inside that MillerCoors David Rankin Kristen D. Milwaukee Millercoors CBS "Next David Rankin has the latest on the sentencing for Roger stone now we check traffic and weather together on the answers Joyce Nielsen and it looks like there may be a lane open now in Burlison north on thirty five W. before hidden creek parkway was completely blocked with traffic being forced off at hidden creek at one point but again looks like there is one lane open at but still seeing a backup though to route around the says to still about a twenty minute delay for the out of Addison northbound bells or toy before Trinity mills had a vehicle fire there that should be working to clear but the right lane is blocked so you back to at least Keller springs in now sell these forward looking at dot road work yeah in the again until the sport worth southbound two eighty seven and will borders place with the left lane blocked off with road work I'm starting to see a slowdown in south east found thirty getting past beach also north fort worth south on thirty five W. passing western center if you tap the brakes and south found thirty five W. from north side down past one twenty one to four street is well little bit slower Haltom city south by one twenty one and hold the road the right lane has room for and we're still dealing with the ongoing road work was done one seventy five at railroad in the right lane not seeing any delays there southbound or north bound seventy five the a little pocket a slow traffic as you come off the bush turnpike heading up towards parked Parker road but that no unusual problems being reported through that stress just a little slow down I enjoy deals on your next report at eleven thirty eight am breaking traffic alerts when they happen stays dry the rest of the day but it also stays Chile hoping to see a bit of sun as we go through the rest of the day and a high right. David Rankin Roger stone Burlison north Chile Joyce Nielsen Keller springs "John little with David Rankin live in the Mercedes Benz of Plano news center now you can pause and rewind live radio it's incredible download the radio dot com map search for KRLD click on the heart to favorite us you might want to pause and rewind this segment because by now I'm sure you're aware the Stephen F. Austin men's basketball team out of Nacogdoches knocks off number one Duke last night eighty five eighty three in to double win for the program and the young man who hit that game winning shot Nate Wayne has quite the story he's from the Bahamas his family lost almost everything in hurricane Doria and all you know is largely about can us and openness he was on ESPN last night the viral moment has help spread the word about his family's plight we're joined by rob Myers the voice of the lumberjacks he was on the call last night rob what is it like to be there in person and experience this for your team it was surreal you're at the Mecca of college basketball Cameron indoor stadium and I think going into the game all we wanted was you know play well give yourself a chance the last four five minutes the game we certainly did that and they took advantage of every opportunity and were able to pull it off and I was almost at a loss for words and she couldn't Shriver because it was it was just incredible coach cal Chester apology for yourself you know play our game and do what we do and we'll see what happens yeah I love that celebration in the visiting locker room at the end but one of the big blessings that comes out of this as well rob is maybe this is a win for a greater cause then DJIA's lumberjack nation here because Nathan pain and their family lost a lot in hurricane Dorian talk about what he lost in his family lost and and how this one is helping him through Freeport Bahamas and his dad is a pastor over there they run a church and school but six hundred kids in their island they lost virtually everything during hurricane in September we the university put together cope on the page they did the research to make sure that it was compliant with interior rolls put together go fund me page to help you know the planes rebuilt their school and you know in fact lot lives are there we raced on a four thousand dollars initially there are just a local awareness you know in our games what not but then last night after that the call just picked up again ironically enough by the tar heel nation they started to read about you know Hey let's go help this guy and the last I saw an hour Sir go over twenty thousand dollars now how may and that's incredible and and he's the guy that had the ball find him at the free throw line street to the other and and made the shot that beat Duke what kind of kid is is Nate bank he is is what I hope that all of them would be like he's a good guy been through a ton of things you have a ton of injuries in the in the time that he's been here he said I think for surgeries couple back surgeries knee surgeries etcetera and then obviously going through the through the hurricane in the Bahamas in September he's he's persevered through all that and still have a lot of family support your park in the back and forth and but he has been embraced by the community and obviously his teammates and nieces Verica enough couldn't be happier with him they got it done it's it's just amazing that only a couple thousand dollars in the account before the moment now it's over eighty thousand dollars as of this moment amazing what a win what a story for SFA and it's it's more than just basketball it's awesome and the university got eighty five grand from do yeah for playing the game exactly it was supposed to be a brush off game for the blue devils this is nuts didn't work that way did it take that blue devils we got extra delays on the freeways because a lot of people heading out of town for thanksgiving we'll check you traffic and weather together on the eight thirty minutes get breaking news alerts from newsradio ten eighty KRLD directly to your phone download the radio dot com after then favorite KRLD when there is breaking. John David Rankin Benz Plano eighty thousand dollars twenty thousand dollars four thousand dollars eight thirty minutes four five minutes thousand dollars What to know about Britain's next prime minister, Boris Johnson "Great Britain's about to get a new prime minister could happen as early as tomorrow after to reason may leaves office London's former mayor Boris Johnson gets to move into ten Downing Street after he's confirmed by the head of state Queen Elizabeth and we find out more about the incoming prime minister from Graham mac he's with fixed radio in London he talked with our David Rankin for it's pretty much split because Boris does have its found but Boris is a bit of a figure of phone the comedian Frankie Boyle described Boris Johnson is looking like a cross between a head injury in an all night back and Boris I had a long time being taken seriously as a politician even though he is a career politician on like you know Donald Trump he did start on television we have a TV show a satirical Hahnel chocolat by got news for you and Boris was often a guest on that show you got to be well known by the British public that made in the matter of London the walls all the training on the TV well you start now with everybody wants him to be running the country did he run the city of London well I thought it's a hard city to run only well I would say if one of his legacies is bush bike cycle around the known as Boris bikes everywhere so if you want to cycle from one side to the other you just like a credit card in the bike and move across town so he got he got Boris bike through he made some big mistakes that we once thought it was when the London riots were on a few years ago after which people to water cannon which from the French I think and it was totally unusual unusable because in New York the in European cities they have huge squares and via the in France and Italy and and Germany we don't really have that but it's all a little street CAF so the water cannon could out this week so it was useless so we spend all that money on that but by and large I think he did he had some some nasty things to say about Donald Trump at one time went when Donald was talking about that crying in London which she still likes to do and forests fired back with since then Boris seems to be very friendly with Donald Trump so I don't know how it goes but I think you did an alright job of running London I remember talking to a journalist at one of the news rooms when the the match changed and he said well the one thing about bars you could always get a hold of and it always give you comments and the media did like in many it's the media that he's being friendly with the knees manipulated the best to get where he is and look at this in a couple days to be the prime minister so what does the future hold as far as breaks it and is it going to be a hard breaks it is it is there going to be some kind of a deal made I don't know I hope so because it'll be the lesser of two evils that have a nice deal where we don't suffer too much would be great for Boris is actually said he's not going to rule out a hard brexit which means we have no deal with the eighty year now trading down office and some of the NBA's impala and said that in fact that the campaigning to walk back in stock I don't know how they'll be able to do that and to be honest with you know a lot of the people a few years ago voted in the actual referendum to leave they would think it was just going to be no deal they didn't realize there was gonna be deals to be done and all the rest of it so we'll just have to Britain Prime Minister Eighty Year "Low ninety David Rankin, the business of the courts goes on. Doesn't matter about that investigation into the shooting at the federal courthouse. Sierra Campbell federal building is still closed for the investigation, but that's not deterring the legal system. Federal judge Barbara Lynn has moved an entire pen trial from her courtroom on the fifteenth floor to SMU's deadman law school. The judge held a conference call with the attorneys out of her home yesterday as things stand investigators are poring over the back side of the building decide that is Jackson street that looking at scuff in the building facade were bullets. Ricky shade, still unanswered, the motive behind shooter, Brian, CLYDE, so far. The F B I has not said why the army veteran opened fire he didn't hit anyone but he was shot dead by security staff. Those with cars parked inside. The perimeter of the crime scene. Tape are being allowed to get those cars. L P Phillips, News Radio, ten eighty KRLD new Dow city council wants to make public safety a top priority in the next budget. Many on the council wanna add more police officers to a department that is nearly seven hundred officers short from where it was in two thousand eleven councilwoman, Carolyn Arnold king says while making the starting salary sixty thousand dollars helps they need to find money in the next budget to hire more. So we cannot go to these town hall meetings continued to feed information. All we're down seven hundred police officers. All we down all whoa is me. I had to tell me she didn't want to hear that, but city manager TC broaden access to do this will require some tough choices public safety of heard throughout not just today, but over my entire tenure here is of great importance. But I've also heard similarly about every other thing that we do in the city is being equally as important report show there. Has close to as many officers leaving the department as being hired Austin York, NewsRadio ten eighty KRLD barbecue joined in Dallas is holding a fundraiser for the tenants that lost their home when that crane fell over last week, the crane that crashed into Ilan city, Light's last week is still sprawled across the street and laying into the building. The operator has no time line to remove the crane, one woman died and hundreds of others lost their home. They won't be allowed to move back in. So big AL's Smokehouse barbecue near love field will host a fundraiser tonight for those residents. People can also donate bottled water close or pet food for tenants and temporary housing in ODI status. Allen sky, NewsRadio tonight, eighty K or will details about that fundraiser are at KRLD dot com and Fort Worth. Prosecutors are laying out their case against Milton Buchanan. He's accused of chasing down latonya party in an apartment complex and stabbing her to death in front of witnesses police say he bolted but later returned to the scene. The police arrested him there, a stabbing happens more than two years ago too complex on the city's north side. It's one of six here at KRLD traffic and weather together on the eight. An auto policy. From state farm gets you collision coverage and. Carolyn Arnold king federal courthouse Allen sky David Rankin Sierra Campbell Barbara Lynn Milton Buchanan Ricky shade SMU army KRLD dot Dow KRLD P Phillips Brian Dallas deadman law school TC Austin York "David Rankin middays here. At News Radio, ten eighty KRLD. You don't have to be out of touch when you are in the middle of your workday. We have your latest information on stories that break throughout the day, right here on KRLD. We are tweet storming the news. We give you all sides of an issue. We are here to keep you informed. On the days of vents. If you have to be out in about during the midday, we still have your traffic and weather together on the it's all day long. Keep it right here on NewsRadio ten eighty KRLD traffic and weather together on the ace NewsRadio ten eighty KRLD. And at nine thirty eight in oak cliff northbound. Thirty-five Passmore Salas. It's an active left lane is affected. There is on the scene. But for now, we are looking at a slowdown that to the sixty seven merge in Irving, eastbound eighty three near loop twelve Walker had an accident reported in the right lane. Not to get a major tie-ups there. Southbound Bush turnpike near walnut hill again in Irving. It's midday roadwork in the left lane starting to slow things just of it. And we've got John Wolf looking at some slowing in northwest Fort Worth turns out, here, north west of loop eight twenty year Saginaw Maine, which is a business to eighty seven. They've got that exit blocked off due to an accident. Some people making their own paths, cutting across the grass so dangerous situation there. But it starting to take the backup is starting to clear up Arlington eastbound twenty pass Matlock. There was a Fender bender that has cleared but still a little bit slow as you make your way on twenty northbound three sixty eight Mayfield. Just starting to set up road work in the left lane slowing traffic coming up from twin also now heading out of Dallas into plano, nor. Found Bush turnpike before northbound Dallas north tollway before the turnpike vehicle that's to be affecting the center lane. And that's the reason we're starting to see a little bit of a slowdown from right around trinity mills. And informing westbound highway eight near Clements roadwork in the left lane continues to slow you from Pinson road. I'm joyce. Nielsen. Your next report at nine forty eight and breaking traffic alerts when they happen. Joyce. Thank you. It is nine forty twenty minutes in front of ten o'clock for air, he'd hospital, air and heat hospital. Here's chief meteorologist Dan off. Yeah. Join this morning. Some clouds overhead temperatures are cooler than they've been for the past. Irving Bush turnpike Dallas Joyce David Rankin middays Passmore Salas chief meteorologist John Wolf Fort Worth Saginaw Maine trinity mills Dan off Bush Nielsen Mayfield Clements Matlock Arlington Walker plano "Eleven fifty. I'm David Rankin should come to know on. As a surprise millennials are having a rough goal that when it comes to their finances. And as well as that mental wellbeing. So what's causing all this? We are joined by Katie hill for market watch on KRLD news. Hey, katie. How are you blame it on social media? I mean at least partially right? I found so much research showing that millennials. Media more than other age groups, and Secondly, their spending habits very much influenced by that. And it's really not close when you divide it up between the twentysomethings in thirtysomethings as far as being on social media. That's right. I mean, d numbers are shocking, right? People ages twenty five to thirty four hundred forty one minutes per day on it for a hundred and five for thirty five to forty four. And it's even lower for those older. So yeah, I mean, it's taken up a lot of their day. And then when you ask them about it like have you ever bought gone onto certain kind of occasion because you thought media? Yes. Have you ever spent money you didn't want to because social media? Yes. You just keep seeing these over and over again. And that's something that we always see on Instagram because a lot of people will go so far as to plan their summer vacations and trips to exotic locations just based on Instagram photos, and what someone else's doing right? They'll do that. They'll see them on vacation day, then we'll also post the photos rights cycle that people can't get out. Like, you know, they're going on vacation days. What else go on it? And they're posting it it goes on. But I mean people are saying, you know, we're spending a lot more money than we mean to. It's just constant pressure to keep up with other people's lifestyles and were on social media so much that we see those lifestyles in our faces. All the time, which is really ironic because most people say that social media's just a bad thing. I mean, it is either. Oh, it's bad. You know, it it's you know, it can lead you to feel lonely or depressed, those are true to and then when you look at his finance aspect, you're like, well, that's just another layer on top of that. Right. So it just it's just a lot to to process any. No, we could spend a little less time on their. Let's be Frank. Spend less money on your money that you don't have if you're spending less time on social media as well. What else did this did your studies? Find. Look at not only finance stuff, but due to your mental health. I mean, look, these are all scary statistics. But all true younger. Adults use social media are much higher risk of depression. They're at high risk for exile. They feel lonelier. I mean, it's. They're all bad. But there's a lot of compounding here. Any no all of a sudden, you're in debt that can't help with your anxiety right to all kind of feed into each other to make it kind of troubling beef for some people a lot of people that are dealing with social media and trying to keep up with the spending. They're also the ones that aren't planning for the future, not squirreling anything away. And when you look at those numbers, it's pretty crazy. The eighteen to thirty four said are more likely than all the other generations have nothing saved gen-x is also likely to say, but they're very young. They have nothing saved. Another survey found that nearly half of young millennial. They do twenty four zero dollars in savings. So yeah, there's not a lot of money in the Bank accounts, then social media exacerbating the money issue. So, you know, it's a lot of process. Thanks. Thank you. Katie hill from marketwatch KRLD, news time is eleven fifty three woman in Canada gave it our best shot. She couldn't convince a court though, that the Canadian lottery should pay her a large amount of money because you can't win a large amount of money in the Canadian lottery the appeals court in Quebec throughout Martha Caras lawsuit. She'd claimed that she had no idea it's such a long shot to win the big money in the lottery carry spot the tickets for twenty years and never won any of the large prizes. She told the court. She didn't know that the odds against winning are. So slim court the court told her that the odds are printed on every single tickets. KRLD news time is eleven fifty four. It is time to check your money downstairs humming. Partly. Katie hill KRLD David Rankin Instagram thirtysomethings Martha Caras Frank Quebec Canada thirty four hundred forty one twenty four zero dollars twenty years "With the family a little bit of window will shake you up late Saturday and especially on Sunday weather today. Just downright gorgeous. Still breezy out north winds gusting to twenty to twenty five today's top out near seventy cool tonight wins relax forty five to fifty under a fair sky tomorrow gorgeous near eighty breezy Sunday. Eighty two for Easter the hunts in the morning catchers will be in the low to mid sixties. Perfect weather better weather next week. Well, Monday, cloudy, seventy five and then a good chance for showers and storms, Tuesday and Wednesday. I'm meterologist Brune off in a care weather. Seventy three degrees in Arlington. Sixty one degrees in Fort Worth at sixty three KRLD. Stay with us, David Rankin relied in the Mercedes Benz, plano news. Check the ten eighty pump watch you're gonna find it right now. Cheapest around in Mansfield said the Tom or the SAM's in Mansfield FM one fifty seven and Debbie lane two forty-three in plano at the Tom thumb on alma and hedge cokes and it's two forty four Fort Worth at Texaco and Clifford and eight twenty card price of a gallon of gas to sixty three to sixty two in Fort Worth gas prices up sixteen cents in a month. Tomorrow twenty years since Columbine. Whoever said time heals all wounds, couldn't have imagined a wound is gaping as Columbine. But unlike so many tales from that day this one a while begins on a happy note briskly, they can call Josh land sophomore Columbine all those years ago is now a husband and father of two Stetson and JJ always looking for something and trying to find the silver lining. Did you find it didn't have family outside or downstairs? Josh's dad? Randy. Fort Worth Columbine Josh land plano Mansfield Mansfield FM Brune David Rankin Arlington Texaco Randy Tom SAM JJ Clifford Stetson Seventy three degrees Sixty one degrees Measles cases nationwide rise to 101, CDC says "Measles. The CDC says the US has already seen more than a hundred cases in two thousand nineteen more than half of those in the state of Washington KRLD's, David Rankin taught with Marie Wilson infection prevention specialist from Methodist, Dallas. It's number sounds really high for the measles. Search for a little bit of context in Texas. We've had seven cases as of February eight and in all of last year. There were only eight cases reported in Texas. And so certainly with the outbreaks that we're seeing across the nation that is concerning. I know the state of Washington has seen more than fifty just on its own Dallas itself has seen one case in five in Houston. A lot of the blame is going to the anti vaccine crowd. Is that a very real reason to blame the increase in measles? Certainly vaccine hesitancy in conjunction with vaccine failure are kind of to the leading reasons why we're seeing increasing cases what is back seen failure phenomenon that occurs them. And I borrow that term from Dr Gregory Poland. She's a vaccine allergists at the mayo clinic, so this is what happens when? How low immunizations around the community. So a lot of people aren't getting vaccinated or you have less than you need to in order to prevent their from being cases. And then what happens is that you can have vaccine failure in immuno compromised people. So they were vaccinated, but because they're sick for some other reason their view system is weakened and the immunity that they built up to that infection. Is now not as able to respond. So they get infected when they're exposed increased risk shoot adults be getting booster shots. There has been no recommendations for that that I'm aware of at this time a lot of these kids are going into their teen years realizing that they never got vaccinations as children, and now they're going out on their own to get their own vaccinations because they've been reading the details, and they feel that they're almost cheated out of getting proper vaccinations. Yeah. That is interesting phenomenon that we're seeing there's several online forums, actually where we're seeing these children or actually even. Spouses, or parents that are raising a child with someone that is hesitant to vaccinate their children. They're looking for those resources, and what what's happening there is we're learning about this term called mature minor. And what that means is that you are at minor, but you are old enough to understand and appreciate the consequences of medical procedure. And some states there's fourteen that allow medical minors to consent. Without their parental consent. But the Texas is not one of those that is Marie Wilson. An infection prevention specialists from Methodist Texas Marie Wilson Dallas Washington CDC United States Dr Gregory Poland Mayo Clinic David Rankin Houston "David Rankin. It's a childhood disease that we never used to hear much about. But it seems to be roaring back. We're talking about the measles CDC says the United States is already seen more than one hundred cases so far in two thousand nineteen and we're only in February more than half of those in the state of Washington, we're joined by Marie Wilson. She's an infection prevention specialist for Methodist Dallas and she's on the KRLD Newsline. So Marie the number sounds really high for the measles this year for a little bit of context in Texas. We've had seven cases as of February eight and all of last year. There were only eight cases reported in Texas. And so certainly with the outbreaks that we're seeing across the nation that is concerning. I know the state of Washington has seen more than fifty just on its own Dallas itself has seen one case in five in Houston. A lot of the blame is going to the anti vaccine crowd. Is that a very real reason to blame the increase in measles? Certainly vaccine hesitancy in conjunction with vaccine failure are kind of to the leading reasons why we're seeing increasing paces what is vaccine failure phenomenon that occurs, and I borrow that term from Dr Gregory Poland teeth the vaccine allergists at the mayo clinic, so this is what happens when. How lo- immunizations around the community? So a lot of people aren't getting back stated or you have less than you need to in order to prevent their from being cases. And then what happens is that you can have vaccine failure in immuno compromised people. So they were vaccinated, but because they're sick for some other reason their immune system is weakened and the immunity that they built up to that infection. Is now not as able to respond. So they get infected when they're spos- increased risk shoot adults be getting booster shots. There has been no recommendations for that that I'm aware of at this time a of these kids are going into their teen years realizing that they never got vaccinations as children, and now they're going out on their own to get their own vaccinations because they've been reading the details, and they feel that they're almost cheated out of of getting proper vaccinations. Yeah. That is interesting phenomenon that we're seeing there's several online forums, actually where we're seeing these children or actually even. Spouses, or parents that are raising a child with someone that is hesitant to vaccinate their children. They're looking for those resources, and what what's happening there is we're learning about this term called mature minor. And what that means is that you are minor, but you are old enough to understand and appreciate the consequences of medical procedure in some states. There's fourteen that allow medical minors to consent without their parental consent. But the Texas is not one of Murray Wilson with Methodist, Dallas cold cases can take years to solve in some cases, in some cases. But every now, and then a criminal just falls in their laps of the cops. Police in Waterville Maine, say a state police officer grabbed a really bad Bank robber. And literally seconds. You see the bad guy had just robbed a Bank. He was running across four lanes of traffic and through a restaurant parking lot. And then boom, he's slipped on ice dropped his gun. And as he was slipping let go of the money, and right, then a gust of wind just blew through and swept that cash all over the parking lot. That wasn't even the worst part of it. It all happened right in front of a state police special agent, the would-be robber was tackled handcuffed and hauled off to jail. Oh. And by the way, the guy's gun. He was a BB gun Scott. Sam's NewsRadio ten eighty KRLD Hollywood's most stylish stars. Marie Wilson Texas Dallas Washington David Rankin United States CDC Methodist Dallas Dr Gregory Poland Murray Wilson KRLD mayo clinic Sam officer Hollywood Maine Houston "Thanks so much for staying with us. It is ten fifty. I'm David Rankin. How many times have you asked yourself? If the classes that you took in high school are pretty well. Useless in your real life. How many times have you actually used a python Korean theorem if the office, well, some schools are used to offer classes, and what they call it life skills today. They're called adulting. Classes and more millennials are looking into them. To learn the basics in what they need to get by in life. We're joined by David Dillard from Katie college prep. He's on the KRLD Newsline. David. Thank you so much for the time. You're welcome. You're welcome. Is there really just no time in regular school for teachers to teach what would be basic life skills? I think there I think there should be. I think there's an application in almost every class that you have to weave this in. But I think there could be special emphasis because I think he is is foundation for creating fully functioning adults. And that's the main issue as far as the disconnect between high school, and actual adulthood is that the tend to learn not these basic life skills, like simply writing a check or or just even face to face communication, well writing a check is one of those things that maybe obsolete shortly anyway, but but it it continues to change their personal finance is one of those things that you assume that parents are addressing but most parents don't understand that very well. Effective communication is one of those things that undermines human beings trajectory in the professional world all the time. Coping with stress and change is something that causes mental illness and causes people to not achieve their full potential. But it's it's something that needs to be taught at a very early age and then just overcoming challenges. That's that's something that we used it used to be taught in in sports in in a competitive activities. It's something that is dealt with in in different walks of faith. But it's it's something that needs to be focused on on all platforms do schools get too much blame for not teaching these kinds of lice skills that perhaps the kids should learn that at home. Well, yes, I think it is hard to expect a school to be responsible for that. That doesn't mean that it shouldn't be on the agenda because it is part of a critical part of the educational experience. And and so we need to look for opportunities to really equip people to be ready for life. Now, a lot of people will look at the various things that they took its go. I think everyone has something in their head that they said, you know, I've never used this particular math theorem in my real life. I've never used physics in my real life. Do we just underestimate what it is that we actually do learn in school and do use in our regular lives. But we just don't realize it or the most important thing you're doing in in school is learning how to learn and yes, you may not specifically apply. Certain aspects of it in your in your future pursuits. But that doesn't mean that you didn't need to be exposed to it and understand that it exists in recognize the value that somebody understands it better than you will schools eventually start bringing life skills back into class. You can find it now in in pockets, you can find it that there are a number of private schools that will have it in place. Actually, when you get into students who are are pursuing vocational phones, they do address it. But when you if you have a high level student that that is planning to go to a tier one school. They don't have time to to stop down to deal with that. And that's unfortunate. David, thanks for the time. You're welcome David Diller from K D college prep. Fifty four KRLD time to check your money for Armani. No LLP for counting and. David Dillard David Rankin David David Diller KRLD LLP K D college "David Rankin spoke with Daniel Castro from CDI about that study goes to show that you know, more and more people are familiar with the technology, and they like it. It's convenient useful. And they don't wanna see the government start limiting how can be used. And that's the that's the whole issue because it raises a whole lot of privacy questions. When did you Serbia? Also look at those concerns as well. We did we tried to ask about where consumers were willing to make trade offs between the opportunities to use facial recognition and the privacy concerns. They might have and the potential benefits. And so the real question with anything -nology is where are you willing to make compromises where are you willing to exchange? A little bit of information about you in exchange for some benefits. So right now, we're seeing facial recognition technology being used to address things like improving security and communities making it faster to go through security lines in airports or board your flight or it's been used in retail environments to look at shoplifters and identify potential threats as well as in the industry. So that when you go to hell, for example, you might walk up, and, you know, automatically be checked into your room without having to go through the usual rigmarole of fighting your identification. What are we not comfortable with? In using facial recognition. Well, the the biggest objections using facial recognition that we saw in our survey were when police departments would be using it if the software is not accurate. Or if it's not very accurate.. David Rankin CDI Daniel Castro Serbia "Twenty I'm David Rankin. In the news for Worthing brothers roofing. It could be a clash of titans between a major app maker. And the two giants that put the apps on smartphones. Apple and Google epic games came out with a massively popular game called for night. Now, it says it's coming out with its own version of an app store to take some of the power away from apple and Google. We're joined by Gary devinki from Bloomberg on the KRLD new sign so Garrett what is going on apple and Google as most of us know are really the only way that you can get an app onto a phone because apple and Google are the ones that control the operating systems and for years. They have a system where app developers pay them a thirty percent commission of whatever they make when they sell out just to be on their app stores, and that's worked pretty well. For a long time. That epic games thinks it's too much and is trying to find a way to change that. And what are they looking to do? So epic games is the maker of video games fortnight. Which is you know, this wildly popular game. It's available all over the world and millions and millions of people use it. And so they found a way to essentially allow people to download it outside of apps store. But the concern is that there may be some security issues that come along with that. However, you know, if they're able to kind of get consumers to sort of start to make this change that thinking is that apple Google follow them and lower the commission rates on their official app. Stores. Has anyone else tried to do this before? And what happened? Ways to get apps onto phone outside of the app store, not really on apple phone but on Google phone, but it's just not really done it again because of those security concerns and at the end of the day. No one with the kind of size at the games was tried. It you mentioned before about the fact that there is a commission involved in this. What's a more realistic commission? According to what epic Games's saying the commission right now is about thirty percents. So three dollars of every ten dollars after golfers. Make has to go back to Google or apple and at the game says that's much much too high. They say that that is a three hundred four hundred percent markup, essentially free money to these companies. They're gonna charge just twelve percent and say that they can still be very profitable with that top percent our app developers following through if they started to approach them about doing something like this, certainly, you know, very excited very responsive to this. It's not out and about yet. It's not available until twenty nineteen. But I think it's very safe to say that especially when it comes to game makers the move by epic games would be very popular if apple and Google blink at this and start resetting commissions to what the developers think is is more fair. What does that do to apple and Google's bottom lines and Google make a lot of money from that, we don't necessarily break it out. But this is a multi-multibillion-dollar business and something that is quite possible for them. Of course, apple Google have many other businesses if just one of several things that they do, but it will shake things up a bit. It will bring some profitability away from those companies, especially because companies like apple is no longer selling more and more phones every year than they used to they're selling more extensive phone, but what they're really betting on the future is services. So that's apple iphone users buying things like apple music, having spending more money on cloud services. And of course, continued by a lot of apps. At the high commission rate. So at the end of the day. It's not going to be something that will cripple these companies. But it will definitely concern investors and people who care about that profitability Vink from Bloomberg the country could see a whole rash of rush divorce cases before the end of the year because of the new tax reform law starting January first people that have to pay alimony to annex won't be able to take that off on their income taxes and the person who gets alimony doesn't have to declare it as income as of two thousand nineteen divorce. Laurie saying say they're seeing a lot of couples scrambling to get something done in just the next three and a half weeks.. apple Google titans Worthing Bloomberg David Rankin Gary devinki Garrett Laurie Vink official KRLD three hundred four hundred per thirty percent twelve percent three dollars Over 40 percent of adults don’t plan on getting a flu shot, despite 2017’s deadly flu season "Of adults in this country. Do not plan to get flu shots this year. These David Rankin talked with the idea he'll Dow go with Methodist Mansfield about flu shots for you to get one every year because every year, we have different strains. So that flu shot his made. Specifically for what they believe will be the predominant a strange for that year. A lot of people are also worried about the the new stories that come out every single year that seemed to show that the flu shot doesn't seem to be providing protection what is the truth about this. End up being a little bit of a guessing game in regards to what strange they pick. But it does offer for most people particularly children and elderly patients, it's important to get it. Because even if you're provide you partial protection from the flu, it's still beneficial, particularly for those people who are more likely to get confrontations like restaurants respiratory problems. Those who are elderly and have other medical conditions are children who don't have a fully-developed immune system. I guess that's the next question. Of course is a lot of parents say that they don't want to give their children the flu shot is that why don't think so. Saying children. Do not have all the defenses that usually adults particularly young adult have against viruses. So by providing the flu shot, they allow that child's immune system to mount at least some level of immune response to the shot which provides them protection in key stage of getting the flu. They don't get it as badly last year particularly had a year where there was quite a few deaths due to the lack of children having the chef. So you could potentially protect your your child and prevent passing or getting complications like respiratory problem. And that's the other issue. Of course is if your child gets the flu, and they don't have the flu shot there. Then contagious to their classmates. Yes, they are to everybody else. And they expose them. That is Dr dania had all go with Methodist Mansfield news continues for reliant air conditioning. The debate always comes FLU Methodist Mansfield David Rankin Dr Dania KRLD Programming Marriott's Starwood hack hits up to 500 million customers "At a breach like this a breach like Yahoo. It seems like there's nothing we can do to protect our own information. It's hard because you're handing your over your data to these companies like Yahoo likes Facebook like Marriott hoping that they'll keep it safe. And you know, you can't not give your information for that'd be good. You have to pay for your room or you have to tell them your Email address. Even a lot of lawmakers have called for companies to stop keeping data when they don't need it anymore. So let's say I stayed at Mary out one five years ago. There's no reason for them to still have my Email address now, but they did and in this scenario, those even though you haven't stayed at Marriott in wild. There's a pretty good chance that your data stolen in this breach. In the frustrating thing about this is we we take all the steps that we can to protect our own information from our own stupidity. But this is something that's completely out of our hands because we trusted another company. A major company to safely handle our information. Yeah. Breaches? Like these are extremely frustrating only because there's really nothing you can do to prevent it from happening outside of, you know, the advice thank don't participate in business in the first place. I mean, you want to trust these companies, but at the same time, you see all these rages like this. And you know, that there once you hand over your data it their individual customers need to do. Now. The best thing that you can do now. Call your credit card company, if you believe that you were a victim of this breach. Change your passwords, if you can and just be wary of suspicious emails or phone call because they have that information now and a lot of scammers will probably reach out to, you know, try to take some more money out of you using the information stolen here. Like, they might call pretending to be from Marriott and try to get your credit card number again or anything like that. That's coming from senior talking to David Rankin from KRLD about the big hack that happened this week infecting, the affecting the Marriott Yahoo David Rankin One Five Years "Ten fifty. I'm David Rankin. Breaking news now NewsRadio ten eighty KRLD. Thanks so much for staying with us. Breaking news out of New Orleans Dez Bryant has finally found another job halfway through the season Dez Bryant has signed a one year deal with the New Orleans Saints. This comes from the NFL network and even Dez Bryant is retweeting that he will be playing for the New Orleans Saints catching passes from drew Brees. And by the way, the New Orleans Saints play the Dallas Cowboys coming up on November twenty ninth shingles patients in Texas, having trouble finding a vaccine there's been an unexpected high demand for this brand new vaccine, which is getting praise already as being far more effective for longer Dr Dominguez with Methodist, Dallas because of the effectiveness and the age being dropped from sixty to fifty recommendations on backs innate. There has been a one on this vaccine has been extremely popular says this is not a nationwide. Shortage. It's only a problem in a few areas. The shingles vaccine is recommended for anyone over fifty who's had chicken pox before. Shingles patients, essentially get that virus all over. Again. The nerve pain is said to be horrific Dominguez says the vaccine's creator shipping it out in huge batches every other week. So that supply can catch up with demand. Kristen Weiss on NewsRadio. Ten eighty KRLD. We are waiting on the president to speak. It looks like it's the East Room of the White House a tradition that hats that hits on the day after the midterms the president usually addresses the nation about the results of the midterm elections. We are expecting him to take the podium here in just a couple of moments. Forget their the Democratic Party efforts to make history in Florida. It fell short of the governor's race run. The Santa's beats Andrew gillum that race and the one to determine who will now live here at the governor's mansion or as high profile as it gets both parties poured millions of dollars into the state. And while poll, so the Democrats might be able to pull off a victory in the end, the nation's third most populous state went largely read. Florida. Dez Bryant New Orleans Saints Dr Dominguez New Orleans Shingles president David Rankin Florida Kristen Weiss Dallas Cowboys NFL White House Dallas Brees Andrew gillum Democratic Party Texas Santa one year Scammers posing as potential employers on the rise, experts say "Thanks for staying with us eleven forty. I'm David Rankin. We're live in Mercedes-Benz, plano news, center Irving. Police arrested man foreign assaults naysayer there might be more victims. They arrested Connor Kleiner Irving. Police say back in April of victim responded to a social media dating site and went to the suspect's apartment in got assaulted during the course of the investigation. Detectives found evidence that Klein had spoken with her met other women please interviewed some of them, but still need to identify others. They're looking for anyone who may have been a victim to give them a call finding the right job can be challenging enough. But now experts are warning people to be on the lookout for scammers that are posing as potential employers Better Business Bureau says fraud with fake job offers. It's now the third riskiest type of scam for consumers expert haven't warning if the job seems to good to be true, it likely is. Employments hams are increasing giving false hope to people looking for work preying on those who are often already struggling to make ends meet. We spoke to one woman who thought her financial burdens were over when she received what she thought was a dream job offer only to be driven deeper into debt. It was a very nice Email unconsidering you please respond back. Tell me a little bit about yourself. Where do you wanna see yourself in three to five years? Kathleen Boylan jumped at Connor Kleiner Irving David Rankin Kathleen Boylan Better Business Bureau Klein Mercedes-Benz Irving Fraud Plano Five Years Ed Bousman 00:49 sec \| 2 years ago Americans distrust self-driving cars more than they used to "Two years ago about thirty percent of us said we would never buy a fully. Autonomous car now that number is up to fifty, percent according to new data from Cox automotive most of us say we are interested now in. A lesser level of self driving a reflection of recent high profile crashes by self-driving Uber's and Tesla's this opens the. Near-term. Door driver assistance technologies that are hitting the market in volume typically called. Level three Cadillac super cruise Audi traffic jam pilot are examples that. Can drive while you oversee them not check out the largest group of people in the. Survey said that. No matter what comes down the road in the future cars should always have the option of being human driven but remember. That many, new technologies have followed a pattern of unreasonable public exuberance followed, by unreasonable public scepticism and then a. Reality somewhere in the Brian Cooley David Rankin Griffin Plano Bloomberg Tom Harrison Google Cox Automotive Tesla Audi Bedford Kleber Krld Murphy Royse Official DFW Microsoft Cutting Carbs Could Cut Years off Your Life "Somebody diets call for you to cut out certain, foods or food groups a new study Lancet public health says don't be. So quick to make cuts in your carbs to few can be risky to your life KRLD David Rankin asked registered. Dietitian Amy Goodson went carbs. Get a bad rap know back in the day right so we have like the no carb diet but if you remember that before that we had the eat all carts like in the nineties we're always talking about eating heart because we didn't, want to eat fat Atkins diet that kind of when that really surface back, in the early two thousand carbs got a bad rap carbonite youth that, are in your life clause implemention etc The truth is carbohydrates. In themselves do not make you fat, they don't make you gain weight it's the excess of eating carbohydrates and what type of CRA hydrates. That you're eating that can really, cause trouble long-term in, your eating habits are there good carbs and bad, carbs? Let's definitely stuff so we talk good car. Relative term so good is meaning more, coke rain in nature so west, processed so that's gonna, be a food at that is higher in fiber it's something like oh they're out. Meal Brown rice Qinhua some of those really whole grain whole wheat Bulger brand things of that nature those are hiring cyber typically also higher intrigued, by, them So those are going to be a better. Choice do I recall though the carp that of course I, would also call. Pop tarts and cookies and very sugary cereal the car. Many, of those are going to have no. Fiber or very little added sugar and be lower nutrients so those are really alas, nutrient rich, choice yet really they're all considered carbohydrates shouldn't there be, a different name for those. One would be typically like in. The nutrition world has a dietitian. Holiday whole grain carbohydrates and yeah that can be very confusing for people because whole grain can be used? Loosely in marketing, on, packages so? Ryan? Courage consumers to. Do is to flip the package over. And look at the ingredients it's the first ingredient. Is whole grain. Whole wheat whole oat whatever it is that's your security that that. Is a whole, grain, products typically that's, gonna, be a. Less processed product the key with that is that fiber helps digestion if you're. Just sitting there eating you know chips all day or Crackers or even you know some. Type, of popcorn or something you're going to. Remain a lot how this that's registered dietitian Amy Amy Goodson Krld Amy Goodson Brian Cooley Audi Cox Automotive CRA Tesla David Rankin Bulger Ryan Two Years Thirty Percent Fifty Percent Richard Gere, Trump and David Rankin discussed on KRLD News, Weather and Traffic "Couple of football notes Dez Bryant I'll start with him says. He wouldn't mind playing for the Cleveland Browns I'm, surprised that nobody's, picked him up nobody's. Picked him up so he says fine. Browns, okay fine. At Bill Snyder coach Kansas Richard Gere Donald Trump David Rankin Abby Huntsman Cleveland Browns Football Bill Snyder Dez Bryant Congress Twitter Reliant Kansas Johnson President Trump Michael Ebanon Apple FOX Sabo Abby Huntsman Exits ‘Fox & Friends’ Franchise To Join ‘The View’ "Stock about Dez Bryant as it's still, a player without, a team yeah no one's picked him up he says I don't know maybe. It's desperation on desert part where. He says he'd be perfectly happy to consider playing for the Cleveland Browns go from. Dallas Cowboys superstar to not playing on a team and been ready to. Go to the Browns Although you know they've got Baker President Trump Cleveland Browns David Rankin Richard Gere Dez Bryant Dallas Cowboys Donald Trump Abby Huntsman Facebook ATI Twenty Twenty Jon Huntsman Baker Mayfield Russia Twitter Michael Daniels Sabo Catherine Zeta-Jones's 15-year-old daughter, Carys, on growing up part of a Hollywood dynasty "After one fan saw the picture, and said I'm praying that peltz. Merrill with that ice cream Reese tweet tweeted no. Need to pray I got her mean she threw. Ice cream Meryl Streep season to probably not. Gonna air until next. Year but can't wait. To see that, that'll be fine in. Michael Douglas's turning this. Morning this is a little interesting, for the, first time of course he's married to, Catherine Zeta, Jones their daughter who's fifteen, she's appearing on her first magazine cover it's. Town and country she's with her mom she's fifteen year old Keris Keris Zita. Douglas and they're talking about the Douglas. Dynasty the family and she says growing up she had no idea what. Her dad did she didn't know he was an actor honestly. Thought he was a, pancake maker They just hired, him to, make breakfast and she also said that, she was, on my gosh she said, she was bullied because of his age because. He was fifty eight when she was born now he's seventy three and yeah To get her some old. Streets of San Francisco rerun watch those here's our David. Rankin our app today today's called translate photo this app can use your camera to translate foreign signs in printed materials into English or. English language signs into a different language it can convert the words instantly into ninety. Different languages you just, have to, take, a picture of the. Sign or the, papers of the books and watch, as the app translates the words you can also listen. Michael Douglas Keris Keris Zita Meryl Streep Merrill Reese Catherine Zeta Rankin San Francisco Fifteen Year Dog heart disease linked to grain-free food, FDA says "Stay cool stay hydrated folks some of the hottest weather we felt so far this summer on the way especially into next week most of you if you haven't hit one hundred yet you will by monday or tuesday of next week still a slight storm chance today with a high of around ninety nine light and variable winds tonight seventyfive tomorrow and in the sunday highs right around one hundred maybe slightly above a heat index values as high as one of five to one zero seven and even hotter weather arrives by next week here we go i'm meterologist brune off in the weather center right now it's eighty two degrees at krld eleven forty thank you so much you're staying with us it is i'm david rankin we are live in the mercedes benz plano news center the fda's warning dog owners about a possible link between some pet food and heart disease agencies alert involves dog food containing peas lentils and potatoes and highly unusual reports relating to weakened hearts and heart failure the reports of focused on dogs that are not genetically prone to the disease known by the initials cdc including bulldogs golden retrievers and many schnauzers the fda is not named the pet food brands but says it's working with the companies to find any possible links mitch card newsradio ten eighty krld some dallas brewers want answers why does it take forty minutes for the cops to show up it was last month that mike perez one of the. FDA Dallas Brewers David Rankin CDC Mitch Mike Perez Eighty Two Degrees Forty Minutes "Of the of plastic pollution care all these david rankin talked with ileana pavlova from bloomberg started with shifting consumer trends if you believe in two thousand fifteen there has been a video about a sea turtle rescued and she had a straw stuck in our nostrils so i think that's was a time when consumer start caring about it and a starbucks actually joins mcdonald's in their effort to limit plastic straws and for starbucks their goal is to limit the plastic straws completely by twenty twenty is that a realistic goal starting slow they're starting with offering trolleybus let's in only two of their during so far and then there will be stras but they will make be made from alternate of materials like paper some people have complained about the paper straws that they don't handle hot drinks very well and others are saying that that they don't like this this whole notion of it of course that would be an issue so i don't think there is one answer to how to substitute the plastic trust and i think right now they're testing several different materials and of course shameless plug bloomberg also uses straw center made out of plants not plastic how does that work then in your office we get strauss it or made of plants in their one hundred percent compostable can you tell. david rankin ileana pavlova bloomberg starbucks mcdonald straw center twenty twenty strauss one hundred percent "The first four boys have emerged from that cave in thailand we get the latest now at eight fifty in a special report cbs news special report at least four and possibly six at the chill trillion trapped in a partially flooded kate and thailand are out this morning and rescuers are going back in for the others and they're soccer coach the bbc's dan jansen explains how they decided which children to bring out i we understand that doctors were in the cave yesterday doctors who have diving capability went to examine them went to look at that physical condition on offense assess their mental strength as well and they decided on a priority list in which the voice should be brought up so starting with the weakest with the ones who are in most need we understand that they have formed into small groups maybe two three four at a time to be guided out by the expert divers eighteen divers went into the cave five of them from thailand the others from the us australia and japan no word yet on the condition of the boys rescue you'd so far but they are being treated at a hospital cbs news special report i'm alison keys now eight fifty one apartment rents continue to go up across north texas complexes are also trying to out compete with other companies to provide the most modern home with the most amenities and that's where the issues come from a lot of people are spending more for their apartments with things they don't really necessarily want david rankin spoke with chris sale vanni from apartment list dot com where we looked at from both the producers on apartment list as well as. thailand kate bbc dan jansen us cbs soccer australia japan texas david rankin chris	cc/2021-04/en_middle_0036.json.gz/line1153
__label__wiki	0.921513	0.921513	Familiar Name Home Again for Mona Shores Posted Wednesday, September 23, 2020 By Tom Kendra Special for Second Half One of the biggest names in Muskegon Mona Shores football history is back at quarterback – after a 40-year hiatus. Mark Konecny, who went on to Alma College and then became the first Michigan Intercollegiate Athletic Association player to make it to the NFL, moved back home from Colorado in 2017. Now it’s his son (same name) who is connecting with receivers for the reigning Division 2 champion Sailors. “It’s kind of cool to be here playing on the same field and practicing on the same field as him,” said Konecny, a 6-foot, 190-pound junior who wears No. 10, while his dad wore No. 11 at Shores. “I came here for a veer camp in the summer before my 8th-grade year and I liked Coach Koziak and the kids and thought it would be a good fit for me, and it has been.” Konecny is the backup to senior Brady Rose (5-7, 172), a state Player of the Year candidate who powered the Sailors to a 35-26 upset of Detroit Martin Luther King in last year’s MHSAA Division 2 Final. But that doesn’t mean Konecny won’t play a key role in Friday’s showdown at crosstown rival Muskegon High. Konecny threw a pair of first-half touchdown passes Friday as Shores picked up right where it left off with a 55-0 pounding of Muskegon Reeths-Puffer in an Ottawa-Kent Conference Green game. While the explosive Rose is a magician running the veer offense, Koziak said having a backup like Konecny with a rocket arm adds another dimension to the attack. “We want to get our best players on the field, but there can only be one quarterback, so it’s kind of a problem,” said Koziak, who led Mona Shores to its first-ever playoff berth in 2013 and then to the Finals three times in the past six years. “Brady is an amazing leader and high school football player, while Mark is more of a prototypical QB who can really spin it. So we’ll try to find unique ways to get them on the field at the same time.” One of those unique ways came in the first quarter Friday, when Konecny lined up as a slot receiver and received a backwards toss from Rose. Konecny then fired his first-ever varsity pass, which a wide-open Elijah Farnum took 59 yards for a touchdown. On the next possession, Konecny took over at quarterback and Rose moved to the slot, the position he played last year before stepping in for injured starting quarterback Caden Broersma early in the Semifinal against Walled Lake Western. With the Puffer defense focused on Rose, Konecny gunned a four-yard scoring pass to a sliding Keondre Pierce on a seam route. The two-quarterback attack might be required Friday at Muskegon, as Shores managed just 15 rushing yards and three first downs in last year’s humbling 53-0 loss to the Big Reds. Muskegon holds a 32-7 all-time edge over Mona Shores, and had won 14 in a row before the Sailors broke through with back-to-back regular-season wins in 2014 and 2015. The Big Reds have since won five straight in the series, including a playoff victory in 2015. Friday’s game will be the first on the new synthetic field turf at renovated Hackley Stadium, where the Big Reds have been playing since 1927. Muskegon coach Shane Fairfield hinted before Monday’s practice that the Big Reds could also use multiple quarterbacks in Friday’s game. Projected starter Amari Crowley did not play in Muskegon’s 59-14 opening win at Holland, but is expected to be back Friday. Junior Myles Walton stepped in last week and rushed for 133 yards and completed 4-of-5 passes for 52 yards. Konecny’s dad remembers classic battles against Muskegon back during his era, and leading the Sailors to a 20-7 win over Muskegon his senior year in 1980 before suffering a season-ending broken collarbone the following week at Traverse City. He was converted to running back at Alma College, where he became the first in school history to rush for more than 1,000 yards in a season with 1,059 in 1984 in earning all-MIAA honors. He played two years in the Canadian Football League, before realizing his dream of playing in the NFL in 1987 with the Miami Dolphins. Konecny’s best NFL season came with the Philadelphia Eagles in 1988, when he returned 17 kickoffs for 276 yards and 32 punts for 226 yards. After football, he worked as a fireman in Littleton, Colo., for 25 years, but fate led him back home to Mona Shores when Koziak invited him to speak at a team fundraiser in 2017. Later that year, the younger Konecny took part in the school’s veer camp and the family decided to come home for good. Things have fallen into place ever since. Konecny got a job with the Norton Shores Fire Department; his wife, Lauri, landed a kindergarten teaching job at Campbell Elementary in the Mona Shores district; and their only child, Mark, quarterbacked the Sailors freshmen to a 7-1-1 record two years ago and the junior varsity to an 8-1 record last fall. The elder Konecny coached the Shores special teams the past two years, but stepped aside during the offseason to give his son some space and just be another dad in the stands. “I want these next two years to be all about him and the work that he has put in,” said Konecny, who was inducted into the Muskegon Area Sports Hall of Fame in 2007. “I just want to be an advocate for him and do whatever I can, lend whatever knowledge or experience I can, to help him achieve his goals.” The younger Konecny is always trying to learn – soaking in lessons from Koziak and offensive coordinator Aaron James about the nuances of the veer offense and working with his father and former MSU quarterback Ryan Van Dyke on the mechanics of quarterback play. But perhaps the best lessons of all come from Rose. “We compete with each other, but we also encourage each other,” explained Konecny, who has played hockey in the past but plans to powerlift and play baseball this school year. “What Brady does on the field just logistically doesn’t make sense for someone his size. But you see him in the weight room and around our teammates, and he’s such a leader. He’s a great influence on me.” Koziak said he has no doubt Konecny will be a college quarterback in a couple of years. “One of the things I really like about Mark is that he has a very inquisitive football mind,” said Koziak. “He wants to know why we do certain things we do in terms of motion or blocking on a particular play – not just what he has to do, but why.” Konecny also has an incredible work ethic, never missing a chance to throw with his teammates or to hit the weight room. He recently became a rare junior skill athlete to join the Mona Shores 1,000-pound club – meaning his combined best lift in the bench, squat and dead lift tops that weight. And when he’s not doing one of those things, he can often be spotted at his dad’s old favorite workout spot: the giant Lake Michigan sand dunes at Lake Harbor Park. “Every so often, we’ll be sitting around the house and he’ll be restless and go run the dunes,” the elder Konecny said with a smile. “Those are the same dunes that I used to run when I played at Shores, so that’s kind of neat. Like father, like son, I guess.” Tom Kendra worked 23 years at The Muskegon Chronicle, including five as assistant sports editor and the final six as sports editor through 2011. E-mail him at kendra.tom@gmail.com with story ideas for Muskegon, Oceana, Mason, Lake, Oceola, Mecosta and Newaygo counties. PHOTOS: (Top) Mona Shores junior quarterback Mark Konecny drops back to pass during Friday's game at Muskegon Reeths-Puffer. (Middle) Konecny warms up Friday. (Below) The elder Mark Konecny. (Mona Shores photos by Eric Sturr and Mike Meekhof, respectively. Head shot courtesy of the Muskegon Area Sports Hall of Fame.) Older, Wiser MCC Ranks with Elite Again By Tom Kendra Special for Second Half Max Price is right – Muskegon Catholic Central football is back. Not that the Crusaders ever went too f... EGR 2-Sport Star Chasing Final HS Goal By Dean Holzwarth Special for Second Half EAST GRAND RAPIDS – Over the past three weeks, John Shelton IV has established a new school record ... 'Gamer' Helps Shores Gut Out 1st Finals Win By Paul Costanzo Special for Second Half DETROIT – Brady Rose walked into Ford Field on Friday carrying the backup quarterback tag. Aft... Drive for Detroit: 11-Player Finals Preview By Geoff Kimmerly Second Half editor There will be no appetizers for this weekend’s MHSAA 11-Player Football Finals at Ford Field. Show up e... Orchard View Buy-In Reaps Big Turnaround By Tom Kendra Special for Second Half It was far from love at first sight. When returning Muskegon Orchard View standouts like senior Dayton Rose a... Muskegon Mona Shores, West Michigan	cc/2021-04/en_middle_0036.json.gz/line1155
__label__wiki	0.918388	0.918388	10/01/21 - Livingston v Ross County LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Marvin Bartley ahead of kick off during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) Paul Devlin - SNS Group LIVINGSTON, SCOTLAND - JANUARY 10: A general view of the Tony Macaroni Arena ahead of kick off during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Ross County's Michael Gardyne ahead of kick off during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Nicky Devlin ahead of kick off during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston boss David Martindale speaks to the media ahead of kick off during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: The Livingston players warm up ahead of kick off during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Ross County manager John Hughes ahead of kick off during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: A match ball is disinfected beside the pitch during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Scott Robinson (left) celebrates his opening goal during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Scott Robinson (centre) celebrates his opening goal during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Scott Robinson celebrates his opening goal during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Josh Mullin in action for Livingston during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Marvin Bartley (left) competes with Ross Draper during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Ross County manager John Hughes during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston manager David Martindale during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Scott Robinson (left) holds off Coll Donaldson during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Ross County's Charlie Lakin (right) celebrates his equaliser during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Ross County's Charlie Lakin scores to make it 1-1 during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Ross County's Charlie Lakin (left) celebrates his equaliser during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Livingston's Marvin Bartley (right) holds off Harry Paton during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group) LIVINGSTON, SCOTLAND - JANUARY 10: Referee Alan Muir during a Scottish Premiership match between Livingston and Ross County at The Tony Macaroni Arena, on January 10, 2021, in Livingston, Scotland (Photo by Paul Devlin / SNS Group)	cc/2021-04/en_middle_0036.json.gz/line1163
__label__cc	0.637611	0.362389	Is marijuana classified as a Stimulant, Depressant, Hallucinogen or Narcotic? Psychology Consciousness Drugs and Consciousness Josef Niño Jayme Marijuana is a fascinating drug, because it's effects varies from one person to another, it has effects that falls under 3 drug categories(Depressant, Narcotics, Hallucinogen) As a Depressant, it can put a person in a parasympathetic nervous system state or a resting state, characterized by shallow breathing, dilated pupils, increased appetite and slower reaction time, behaviors usually observed upon people, who are resting or relaxed. This improves appetite in people with HIV/AIDS. As a Narcotic, it can inhibit or prevents the feeling of pain, it can treat chronic pain and muscle spasms in people, who had experience major accidents or Epilepsy. As a Hallucinogen, it can produce illusions/mental images. People report using hallucinogenic drugs for more social or recreational purposes, including to have fun, help them deal with stress, or enable them to enter into what they perceive as a more enlightened sense of thinking or being. Hallucinogens have also been investigated as therapeutic agents to treat diseases associated with perceptual distortions, such as schizophrenia, obsessive-compulsive disorder, bipolar disorder, and dementia. Marijuana, has different varieties, each variety has different major effects, upon the body. And how the body respond to Marijuana differ from one person to another. That's why we have different classifications for Pot-smokers. Do drugs impact a person's reaction time? Is Marijuana a depressant? What are the effects of stimulants? Is marijuana a stimulant, depressant, hallucinogen or narcotic? Is codeine classified as a Stimulant, Depressant, Hallucinogen or Narcotic? Is alcohol classified as a Stimulant, Depressant, Hallucinogen or Narcotic? Is cocaine classified as a Stimulant, Depressant, Hallucinogen or Narcotic? Is heroin classified as a Stimulant, Depressant, Hallucinogen or Narcotic? Is LSD classified as a Stimulant, Depressant, Hallucinogen or Narcotic? Are barbiturates classified as a Stimulant, Depressant, Hallucinogen or Narcotic? See all questions in Drugs and Consciousness 98279 views around the world	cc/2021-04/en_middle_0036.json.gz/line1167

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