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Rocket Yard > OWC News > Powered By OWC: Luke Wooten, Owner of Station West Studios
Powered By OWC: Luke Wooten, Owner of Station West Studios
OWC NewsfeedOWC NewsPro Corner
posted on Mar. 03, 2020 March 5, 2020
Luke Wooten is the owner of Station West, a recording studio complex located in Nashville, TN. As both a Producer and Engineer, Luke has earned dozens of #1s and multiple awards with artists such as Dierks Bentley, Brad Paisley, The SteelDrivers, and The Louvin Brothers. Over the past 20 years, he has collaborated with producers such as Frank Liddell, Brett Beavers, and Carl Jackson. In 2014 Luke launched Station West Music, an independent publishing company and home to country songwriter Jordan Brooker.
A few of the OWC products that he and his studio can’t live without are the Thunderbay 4, Mercury Extreme Pro SSDs, and Thunderbolt Docks. “It definitely makes a major difference in boot times and loading sessions when we’ve gone and maxed out all the machines,” says Wooten in regards to how OWC has streamlined his studio’s workflow.
OWC Newsfeed March 3, 2020
How to Manage Tabbed Windows in Safari on a Mac
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Director and Producer Steven LaMorte on Remote Video Production During COVID-19
SoftRAID Comes to the M1 Macs
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Home > CLARREO Approach for Reference Intercalibration of Reflected Solar Sensors:...
CLARREO Approach for Reference Intercalibration of Reflected Solar Sensors:...
Roithmayr, C., C. Lukashin, P. Speth, K. J. Thome, B. Wielicki, and D. Young (2014), CLARREO Approach for Reference Intercalibration of Reflected Solar Sensors: On-Orbit Data Matching and Sampling, IEEE Trans. Geosci. Remote Sens., 52, 6762-6774, doi:10.1109/TGRS.2014.2302397.
The implementation of the Climate Absolute Radiance and Refractivity Observatory (CLARREO) mission was recommended by the National Research Council in 2007 to provide an on-orbit intercalibration standard with accuracy of 0.3% (k = 2) for relevant Earth observing sensors. The goal of reference intercalibration, as established in the Decadal Survey, is to enable rigorous high-accuracy observations of critical climate change parameters, including reflected broadband radiation [Clouds and Earth's Radiant Energy System (CERES)], cloud properties [Visible Infrared Imaging Radiometer Suite (VIIRS)], and changes in surface albedo, including snow and ice albedo feedback. In this paper, we describe the CLARREO approach for performing intercalibration on orbit in the reflected solar (RS) wavelength domain. It is based on providing highly accurate spectral reflectance and reflected radiance measurements from the CLARREO Reflected Solar Spectrometer (RSS) to establish an on-orbit reference for existing sensors, namely, CERES and VIIRS on Joint Polar Satellite System satellites, Advanced Very High Resolution Radiometer and follow-on imagers on MetOp, Landsat imagers, and imagers on geostationary platforms. One of two fundamental CLARREO mission goals is to provide sufficient sampling of high-accuracy observations that are matched in time, space, and viewing angles with measurements made by existing instruments, to a degree that overcomes the random error sources from imperfect data matching and instrument noise. The data matching is achieved through CLARREO RSS pointing operations on orbit that align its line of sight with the intercalibrated sensor. These operations must be planned in advance; therefore, intercalibration events must be predicted by orbital modeling. If two competing opportunities are identified, one target sensor must be given priority over the other. The intercalibration method is to monitor changes in targeted sensor response function parameters: effective - ffset, gain, nonlinearity, optics spectral response, and sensitivity to polarization. In this paper, we use existing satellite data and orbital simulation methods to determine mission requirements for CLARREO, its instrument pointing ability, methodology, and needed intercalibration sampling and data matching for accurate intercalibration of RS radiation sensors on orbit. We conclude that with the CLARREO RSS in a polar 90° inclination orbit at a 609-km altitude, estimated intercalibration sampling will limit the uncertainty contribution from data matching noise to 0.3% (k = 2) over the climate autocorrelation time period. The developed orbital modeling and intercalibration event prediction will serve as a framework for future mission operations.
Radiation Science Program (RSP)
CLARREO
Page Last Updated: September 10, 2014
Page Editor: Amber L. Richards
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Essay-Samples.com
Home - Thesis - Sociology of Race
Sociology of Race
Category: Thesis
Subcategory: Social Science
Level: Academic
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Origin of the Race Theory
Relationship between Race and Modernity
Description of Sociological Theories on Race and Modernity
The oldest field in sociology has been the study of racism; ironically, it may be the least developed theoretically. Study of race relations has moved through distinct phases characterized by particular theoretical orientations, ideological inclinations, policy implications and political ramifications. Since the 19th Century, sociological viewpoints on race have rapidly developed and modified, always showing changes in large-scale procedures. There has been extensive misunderstandings and anxiety about the sociological and political importance, and even the deeper meaning of race. This unclear situation expands into the field of sociology, which has since its beginning dedicated considerable attention to racism and its themes.
The level of the literary works on the race alone provides complications for any attempt at theoretical summary and features. A variety of ideas from both the classical and contemporary customs can easily be used to racial issues. Modifications among national and social understanding of the value of race cry out for relative approaches. World history has probably been racialized since the surge of the “modern globe system”; racial structure rests global even in the post-colonial present. “Popular” ideas of competition, however, assorted, stands, in general, daily use globally. Thus, any valid sociological concept of race requires comparative historical and political elements and a sufficient micro-sociological account.
When the civil war ended, the slaves and their masters alike were unprepared for the complete rupture of their established relationship. Neither the nation’s political and civic leadership nor its scholars had given any serious thought to the future the very many emancipated slaves. As the civil war ended, sociologist took in considerations the changes and dynamic approaches in the sociology of race. It has, however, given an insight in a deeper concentration on how the society has embraced the idea of racism and how it has affected the nations and the cultures which were hit by the race issue.
This paper focuses on the theoretical dimensions of racism in the modern world and how various sociological concepts have addressed the relationship between the modern world and racism. The study considers how the theme of the race took its present range of meanings with the rise of modernity.
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Classical Indian Dance
Esther Mira
World Premiere of “Animal Farm” East 15 Acting School May, 2013
V-Day at East 15 Acting School in Loughton, U.K. February, 2014
Cast Photo of “The Vagina Monologues” East 15 Acting School in Loughton, U.K. February, 2012
Backstage getting ready for the opening of “Yerma”. East 15 Acting School Spring, 2012
“Yerma” East 15 Acting School Spring, 2012
“Victory” East 15 Acting School Spring, 2013
“Rumpelstiltskin” at The West Valley Playhouse Children’s Theatre in Canoga Park, CA. Spring, 2014
World Premiere of “Digby’s New Wife” at The Avery Schreiber Playhouse in North Hollywood, CA. Spring, 2014
World Premiere of “EgoManiac: A Poetic Incantation” at The Actors Company: Other Space Theatre. Hollywood Fringe Festival June, 2014
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Los Angeles Premiere of “Cecily” at The Stephanie Feury Studio Theatre. Hollywood Fringe Festival June, 2014
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Cast, Dramaturg and Playwright of “Nobody’s Child”. Lounge Theatre, Los Angeles, CA. April, 2015
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World Premiere of “Women w/o Walls” at The Lounge Theatre in Los Angeles, CA. Fall, 2015
World Premiere of “Revolution In A Catsuit” at The Bootleg Theater in Los Angeles, CA. Spring, 2017
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West Coast Premiere of “With My Eyes Shut” at studio/stage. Winner Best in Dance & Physical Theatre and The Encore Producers’ Award at The Hollywood Fringe Festival, June, 2018.
“The Dark Horse” at The Hudson Theatres in Los Angeles, CA. 2Cent Theatre’s 6th Annual Acting Out INK Fest in March, 2019.
“Initial Velocity” at The Hudson Theatres in Los Angeles, CA. 2Cent Theatre’s 6th Annual Acting Out INK Fest in March, 2019.
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Μετάβαση στο περιεχόμενο Δυνατότητα πρόσβασης Επικοινωνήστε μαζί μας
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Προστατεύστε τα εμπορικά σήματα, τα σχέδια και τα υποδείγματά σας στην Ευρωπαϊκή Ένωση
Προστατεύστε τη διανοητική σας ιδιοκτησία στην Ευρωπαϊκή Ένωση
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Ηλεκτρονική αναζήτηση (eSearch) νομολογίας Αποφάσεις ΓΕΕΑ, αποφάσεις Γενικού Δικαστηρίου/Δικαστηρίου και εθνικά δικαστήρια που εκδικάζουν υποθέσεις δικαιωμάτων διανοητικής ιδιοκτησίας
TMview Τα εμπορικά σήματα στην Ευρωπαϊκή Ένωση
TMClass Ταξινόμηση εμπορικών σημάτων
DesignView Σχέδια και υποδείγματα στην Ευρωπαϊκή Ένωση
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Πριν από την κατάθεση αίτησης καταχώρισης
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Σχέδια και υποδείγματα στην Ευρωπαϊκή Ένωση
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Αρμόδιοι για τον χειρισμό υποθέσεων EDR (αποτελεσματική επίλυση διαφορών)
Οδηγός για τα σήματα της ΕΕ
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Καταχώριση με τη διαδικασία FastTrack
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EUIPO - Αρχική σελίδα
Alicante news
Our newsletter provides information on all aspects of trade mark and design law and administration.
Alicante News is also the forum for news and debate on wider issues of intellectual property development in your area and worldwide.
Our trade mark and design sections carry monthly articles on current EUIPO practice. Our case-law section provides a monthly run-down of cases brought before the Boards of Appeal at EUIPO and the courts in Luxembourg.
You can receive this newsletter every month in your email inbox
For more information on how we manage your personal data, please read our Data Protection and Privacy Notice.
Alicante News latest edition
Supporting SMEs in the EU
Small and medium sized enterprises (SMEs) are the backbone of the EU’s economy. There are approximately 25 million SMEs in the EU, which together support two out of every three jobs here.
Download PDF, print-friendly version
NovemberShow Hide
Enter GIview
Looking at a list of Europe’s geographical indications is like taking a deep dive into the history and heritage of our continent.
OctoberShow Hide
Use of IPR bundles by EU firms
A new study from the EUIPO investigates how EU firms simultaneously use different types of intellectual property rights (IPRs) for the same products.
SeptemberShow Hide
The EUIPO Academy Learning Portal
In our knowledge economy, intellectual property is fundamental. For businesses of whatever shape and size, for creators and innovators across a variety of disciplines, for students – the creators and innovators of tomorrow – intellectual property plays a fundamental role
JulyShow Hide
Effective Dispute Resolution for SMEs at the EUIPO
Europe’s economy depends on SMEs. They make upover 99% of all EU businesses, generated EUR 4.3 billion worth of value in 2019 and account for two thirds of overall employment.
JuneShow Hide
EUIPO’s Strategic Plan 2025
The launch this month of our Strategic Plan 2025 is another milestone for us, and one which we reach at a very challenging time for many businesses across Europe and beyond.
MayShow Hide
COVID-19 – Guidance Note on time limits after end of extension period
As a response to the exceptional circumstances created by the COVID-19 outbreak, the Executive Director of the EUIPO issued Decision No EX-20-3 and the consequent Decision No EX-20-4, both of which concern extension of time limits in proceedings before the Office.
AprilShow Hide
Supporting users: by the Executive Director of the EUIPO
At this difficult time, when we face a global health and economic crisis, the EUIPO would like to assure our customers and users that we are ready to help.
MarchShow Hide
Extension of time limits COVID-19
In order to provide users with further guidance on Decision No EX-20-3 extending time limits expiring between 9 March 2020 and 30 April 2020 in the context of the coronavirus outbreak, the following clarification has been issued about the time limits affected by the extension, the nature of the extension and the measures to adapt communications sent to users.
FebruaryShow Hide
Decision of ECJ Case C 371/18, Sky and Others
The EUIPO has welcomed the decision of the Court of Justice of 29 January 2020, in Case C 371/18, Sky and Others, in the context of a request for a preliminary ruling.
January Show Hide
Impact of the UK’s withdrawal from the EU: EUTMs and RCDs - updated information
In accordance with the Withdrawal Agreement concluded between the EU and the UK (read the latest news here), the UK left the EU on 1 February 2020.
December Show Hide
Consultation on CP12 – Evidence in Trade Mark Appeal Proceedings
The draft Common Practice of the project CP12 ‘Evidence in Trade Mark Appeal Proceedings: filing, structure and presentation of evidence, and the treatment of confidential evidence’ has been made available in English for comments.
November Show Hide
EUIPO Strategic Plan 2025 approved by Management Board
On 20 November 2019 the new Strategic Plan 2025 (SP2025) of EUIPO was approved by the Management Board of the Office with the unanimous support of the member states and the Commission and will therefore begin its implementation period on 1 July 2020.
October Show Hide
DesignEuropa Awards 2020
The application and nomination period for the DesignEuropa Awards is now open, and runs until 20 April 2020.
September Show Hide
Improved TMview version launched in beta
In November 2009, TMview took its first steps into the digital world.
July Show Hide
Looking to the IP Horizon
On 26 and 27 September 2019, the EUIPO will host the ‘IP Horizon 5.0 Conference: Mapping opportunities and challenges in a globalised economy’ at its premises in Alicante, Spain.
June Show Hide
New eAppeal Version 2: new improvements for users
The eAppeal tool, which allows users to fle an appeal online, has been improved to make it quicker and easier than ever to use.
May Show Hide
IP Horizon 5.0
Mapping opportunities and challenges for IP in a globalised economy
On 26 and 27 September, the EUIPO, in association with the McCarthy Institute at Golden Gate University, San Francisco, hosts the IP Horizon 5.0 conference, the first such event of its kind ever organised by the Office.
April Show Hide
Mediation at EUIPO
On May 30-31, the EUIPO will hold the Ofce’s second ever mediation conference, reflecting both the interest in and the popularity of mediation as a growing discipline within intellectual property.
March Show Hide
The New Generation Guidelines
The New Generation Guidelines were published in the EUIPO webpage on the 4th March 2019.
February Show Hide
The Anti-Counterfeiting Blockathon Forum
The EUIPO has launched a new forum designed to encourage the development of cutting edge technological solutions to combat counterfeiting.
Evaluation of EU legislation on design protection
Design is a motor of economic growth and employment here in the European Union, as well as being an important driver of international trade.
Stakeholder Consultation: Strategic Plan 2025
The EUIPO is calling upon all stakeholders to help guide the Ofce’s strategic priorities up until 2025
DesignEuropa Awards 2018: winners revealed
Two outstanding European designs have been honoured at the DesignEuropa Awards in Warsaw.
DesignEuropa Awards 2018 finalists and Lifetime Achievement Award Winner announced
The names of the DesignEuropa Award finalists and Lifetime Achievement Award winner have been revealed.
Change of EUIPO bank account: closure of BBVA account
On 17 February 2018, one of the two bank accounts used by EUIPO to which users can transfer fees, current account replenishments and charges changed
Trade marks and geographical indications: future perspectives conference at EUIPO
The EUIPO, together with the Directorate General of Agriculture and Rural Development at the European Commission (DG AGRI) is jointly organising a major conference on trade marks and geographical indications, to take place in EUIPO’s headquarters in Alicante on 3-4 October
EUTMs and RCDs in focus: 2010-2017
For the frst time, EUIPO has commissioned two reports, one on trade marks and the other on designs, showing the full evolution of growth of both unitary intellectual property rights since the start of the decade.
Anti-Scam Network meeting at EUIPO
Misleading invoices have long been a problem for intellectual property ofces worldwide, and their users.
Reminder: Change of Bank Account at EUIPO
On 17 February 2018, one of the two bank accounts used by the Ofce changed. The BBVA bank account was replaced by one with Banco Santander
DesignEuropa Awards: apply today!
Applications and nominations for the second edition of the DesignEuropa Awards (organised by EUIPO), can be submitted until 15 May.
DesignEuropa Awards: Apply or nominate before 15 May!
Building on the success of the first edition held in Milan in 2016, the call for entries for the second edition of the DesignEuropa Awards is well underway.
Powering ahead: international cooperation at EUIPO
Embedded in the core business of the Office under the amended trade mark Regulation and spanning nearly every continent and region in the world, international cooperation is gearing up for another intense year of activity at EUIPO.
Common Communication on the representation of new types of trade marks
The elimination of the graphical representation requirement from the definition of EU and national trade marks is one of the key changes brought by Directive (EU) 2015/2436.
EUIPO announces the second edition of the DesignEuropa Awards
Following on from the highly successful first edition, the DesignEuropa Awards are now open for nominations and applications.
20 years of the Boards of Appeal at EUIPO
In 1997, the year in which the Boards of Appeal took their first decision, just 20 appeals were filed.
Second phase Legislative Reform
On Sunday 1 October 2017, the second phase of the Legislative Reform process entered into force.
Key User Programme for advanced IP management
The Key User Programme, launched in 2017, supports users to become more efficient by offering advanced IP management solutions.
The countdown is on
The publication of Regulation (EU) 2017/1001 of the European Parliament and of the Council of 14 June 2017 on the European Union trade mark, codifying Council Regulation (EC) 207/2009 (EUTMR), in the Official Journal of the European Union was yet another milestone in the next wave of changes brought about the legislative reform process.
TMview: the international expansion
With a database that stretches across the globe, and more than 44 million trade marks, TMview is now the world’s largest, free, online trade mark search engine.
New eAppeal: File an appeal online!
The new eAppeal, available since 10th April, allows users to file an appeal online. eAppeal is designed to make filing an appeal as efficient as possible, and is part of the Office’s commitment to providing high quality electronic services to its users.
Second phase of legislative changes: 1 October 2017
On 23 March 2016, the first wave of changes brought about by the entry into force of Regulation (EU) 2015/2424 (the Amending Regulation) came into force. However, some parts of the Amending Regulation will only apply from 1 October 2017.
Anti-Fraud Network meeting at EUIPO
A year on from the publication of the first ever Common Practice on designs, the second European design convergence initiative reaches completion...
DesignClass Phase II goes live
The revised Guidelines for Examination of EU Trade Marks and Registered Community Designs
On 12 December 2016, the Executive Director of the EUIPO signed the Decision adopting the first part of the revised Office Guidelines...
The DesignEuropa Awards – winners announced!
On November 30, the DesignEuropa Awards winners were announced at a ceremony in Milan...
DesignEuropa Award finalists and Lifetime Achievement Award winner announced
The DesignEuropa Awards finalists in the Industry and Small and Emerging Companies categories are revealed today, along with the winner of the Lifetime Achievement Award...
European Cooperation at EUIPO
On September 12-15, the first round of working groups attached to the European Cooperation projects, the successor projects to the Cooperation Fund and the Convergence Programme, met in EUIPO’s headquarters in Alicante....
Declarations under Article 28(8)
On March 23, 2016, the EU trade mark regulation (EUTMR) amended by Regulation (EU) 2015/2424 of the European Parliament and the Council amending the Community trade mark regulation entered into force...
DesignEuropa Awards – last chance to nominate or apply!
On July 15, the entry period for the DesignEuropa Awards closes. But with two weeks left to go before the deadline, there is still time to send an application or nomination through the DesignEuropa Awards section in the EUIPO website...
Apply or nominate for the DesignEuropa Awards
Three categories, three winners – and only six weeks left to apply or nominate. ....
The DesignEuropa Awards - nominate or apply before July 15
The importance of design to the EU economy was underlined by the 2013 EUIPO/EPO study on "Intellectual Property Rights Intensive Industries: contribution to economic performance and employment," which showed that design-intensive industries generate 12% of all jobs in the European Union and almost 13% of its GDP....
We are EUIPO
On March 23, 2016, Regulation (EU) 2015/2424 entered into force and the Office for Harmonization in the Internal Market (OHIM) became the European Union Intellectual Property Office (EUIPO)....
March 23, 2016 – from OHIM to EUIPO
The countdown to the changes brought about by the entry into force of the amending EU trade mark Regulation is well underway...
IP Case Law Conference at OHIM
The world of IP case law is a vibrant and constantly moving one...
EU trade mark legislation published
The legislation which introduces a new EU Trade Mark Directive and amends the existing EU Trade Mark Regulation was published in the Official Journal...
Five years of the Cooperation Fund
When it began, five years ago, the Cooperation Fund was the biggest single programme in OHIM's history...
ASEAN IP tools and cooperation
On August 25, 2015, the worldwide network of TMclass and Designview got bigger...
New online design application form
On September 28 OHIM released an improved version of the online design application form. The new form is aligned with the structure and features of the current trade mark application process...
Updated Guidelines enter into force
This month's edition of Alicante News contains summaries of the second set of OHIM's updated Guidelines, which provide users with an overview of the modifications that the Office has implemented...
INTA TMAP meeting at OHIM
At the International Trademark Association (INTA), we recognize the value and importance of trademark administrators (TMAs)...
IP Mediation Open Day at OHIM
On June 15, 2015, OHIM will hold its first ever IP Mediation Open Day...
Five years of TMview
In April 2015, TMview marked its fifth year of existence. When it began, in 2010, it had around 4 million trade marks and data from eight EU national and regional IP offices, plus OHIM and WIPO...
The economic impact of counterfeiting and piracy in the cosmetics and personal care sector
Sales of counterfeit perfume, makeup and personal care items like sunscreen and shampoo throughout the EU mean that legitimate manufacturers, retailers and distributors lose €4.7 billion of revenue each year...
OHIM's digital journey
January 2015 marked the first full year of OHIM's new website; a site which is designed with four key objectives in mind...
Public consultation on the OHIM Strategic Plan 2020
As the OHIM Strategic Plan 2011-2015 is drawing to an end, the time has come to further the work that has been done and develop a strategy for the future...
CF300 – a milestone for the Cooperation Fund
On December 16, 2014, the Cooperation Fund marked 300 implementations by national and regional IP offices of its tools and services...
The start of a new life for Creative Works
A new database for "orphan works" has just been launched by the Office for Harmonization in the Internal Market (OHIM)...
Community trade mark applications will now only be examined after they are paid for
We are changing our examination workflow to increase efficiency.
OHIM User Satisfaction Survey to be launched during October
OHIM is committed to providing the highest quality standards to its users and has been incrementally stepping up its efforts to achieve maximum satisfaction in all areas...
The Enforcement Database – linking business and enforcement
The idea behind the Enforcement Database (EDB) is very simple. It provides a secure channel for businesses to exchange information with enforcement officials – information that could be vital in tracking down counterfeit products...
Anti-Fraud Network meets at OHIM
On June 16, the first meeting of the Anti-Fraud Network was held in OHIM's premises in Alicante. It gathered together delegates from EU national and regional offices, user associations and international IP organisations to discuss the problem of misleading invoices and to formulate ways to combat it...
OHIM Guidelines for Examination
On August 1, the OHIM Manual will be phased out and all of OHIM's practice will be contained in its Guidelines. It will be the final step in a process which has involved OHIM legal experts, EU national and regional IP offices and user associations, in order to ensure that OHIM's practice rules are fully up to date...
HIM at INTA: Hong Kong
The INTA Annual Meeting is a key date in the annual international IP calendar. It gathers together IP professionals from all over the world for discussion, debate and networking – and has become a fixture on the world IP circuit...
Twenty years of the CTM0
Twenty years ago, the CTM system was set up. The CTM Regulation entered into force on 15 March 1994 and ushered in a system which has since become a true success story for the EU and the internal market ...
Alicante News, February edition
Twenty years ago, the CTM system began. On 15 March 1994 the CTM Regulation entered into force and ushered in the system ...
Alicante News, January edition
As we reported in the last edition of Alicante News, a number of technical issues overshadowed somewhat the launch of the Office's new website.e..
Alicante News, December edition
From its earliest days, OHIM has embraced the rapidly evolving world of technology, and was one of the very first international IP offices to launch a website, back in 1998, with the very first iteration of what would become the hugely popular OAMI Online...
Alicante News, November edition
OHIM´s new website brings a new online look and feel to the Office. The site has been developed in collaboration with users, who have tested its functionalities and provided valuable feedback through the development process...
Alicante News, October edition
Two years ago staff from OHIM and the EPO started work on a major study to settle the question of how important IPR-intensive industries are to jobs, GDP and trade in the EU..
Alicante News, September edition
Alicante News, July edition
With the summer vacation period now upon us, it time for Alicante News' traditional summer rundown of OHIM's activities during the first half of 2013.
Alicante News, June edition
The month of June has seen significant activity at OHIM in the field of the Office's Cooperation Fund and Convergence Programme initiatives, with a number of meetings in different areas over the course of the month.
Alicante News, May edition
The Administrative Board and Budget Committee members, together with Commission representatives, as well as observers from WIPO, EPO, Croatia, the Benelux Office for Intellectual Property (BOIP) and several users associations attended the sessions of the Administrative Board, Budget Committee and a Joint meeting.
Alicante News, April edition
For over a decade, the Office for Harmonization in the Internal Market has been a regular visitor to the Annual Meetings of the International Trade Mark Association (INTA).
Alicante News, March edition
After months of painstaking preparations and organisation, the long-awaited tenth birthday celebrations of the Community design system are just around the corner, as Alicante gets ready to host the biggest EU design event of the year.
The European Observatory on Infringement of Intellectual Property Rights is now well embedded into OHIM, and is preparing to show results on several of its key projects in 2013.
On 1 April 2003, the first registered Community design (RCD) applications began to arrive at OHIM's Alicante headquarters. By the end of that very first year, the Office had received and processed almost 40 500 design applications.
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Salsa Stories
Lulu Delacre
Salsa Stories explores Puerto Rican holidays, with rich descriptions of the culture and traditions of celebrations throughout the year.
Sarah, Plain and Tall
Patricia MacLachlan
19th century tale of a widowed farmer with two children who advertises for a wife. The answer to his ad is Sarah, who arrives from Maine. The tale gently explores themes of abandonment, loss and love.
Separate But Not Equal: The Dream and the Struggle
Jim Haskins
A history of black education in the United States.
Seven Brave Women
Betsy Hearne
Author Betsy Hearne entertains readers with stories about seven generations of women in her family, from the Revolutionary era to today. In the lives they built and the objects they left behind, the author finds a legacy of strength, courage, and wisdom that spans the link between mothers and dau
Shake It, Morena! And Other Folk Tales From Puerto Rico
Carmen T. Bernier-Grand
This collection of folk tales features games, songs and riddles from Puerto Rico.
So You Want to be President?
Judith St. George
A creative children's book full of fun facts and information about U.S. Presidents in our history.
Somos como las nubes / We Are Like the Clouds
Jorge Argueta
Why are young people leaving their country to walk to the United States to seek a new, safe home? Over 100,000 such children have left Central America. This book of poetry helps us to understand why and what it is like to be them. This powerful book by award-winning Salvadoran poet Jorge Argueta des
Sparrow Jack
In 1868, John Bardsley, an immigrant from England, brought one thousand sparrows from his home country back to Philadelphia, where he hoped they would help save the trees from the inch-worms that were destroying them. Based on a true story.
Stanley Hayami, Nisei Son
Joanne Oppenheim
Adult,High School,Middle School
The biography of Stanley Hayami, a Japanese American internee and soldier, told through his diary and letters
Stories from Puerto Rico
Robert L. Muckley
Bilingual stories from Puerto Rico that illustrate the rich culture and history of the island.
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Home Hearing Loss Single-Sided Deafness
Posted on December 19, 2018 by Audiology Associates of Holladay
Single sided deafness (SSD), sometimes referred to as unilateral hearing loss, is a condition in which an individual experiences hearing loss in only one ear but can hear normally out of the other ear. While the majority of patients with a hearing impairment suffer from bilateral (two-sided) hearing loss, SSD is diagnosed in approximately 60,000 people in the United States each year.
There is no cure, and treatment can be a challenge because traditional amplification devices prove less effective. However, alternative options are available for managing single sided deafness.
What Causes Single Sided Deafness?
SSD can be caused by a variety of factors. One of the most common causes is acoustic neuroma, a benign, slow growing tumor that can push against the auditory nerve and affect the ability to hear properly in one ear.
Sudden deafness – a rapid onset of hearing loss that occurs with little or no warning, often following a viral infection – is another condition commonly associated with SSD. Patients may fall victim to sudden deafness as a result of an inflammation in the cochlea that causes permanent damage to the hair cells responsible for hearing.
Additional causes of SSD include trauma to the head, genetic disorders, Meniere’s disease, labyrinthitis, microtia, mastoiditis and even common childhood diseases such as measles and bumps.
Patients with SSD find understanding speech in the presence of background noise especially problematic and have great difficulty localizing sound (recognizing the location or origin of a sound source). Sound localization depends on subtle hearing cues from two ears; removing one from the equation confuses the brain. Other symptoms might include anxiety, stress, social isolation, dizziness, difficulty paying attention and speaking loudly.
Treatments for SSD
While there is no cure for single sided deafness, options exist for helping patients cope with unilateral hearing. Traditional hearing aids don’t offer much help to those suffering from SSD, but Contralateral Routing of Signal (CROS) hearing aids can improve hearing and localization.
They utilize a microphone that is placed in the vicinity of the impaired ear and an amplifier near the normal ear. The microphone picks up sounds and transmits them to the patient’s “good” ear. A similar device known as BICROS is suitable for individuals with some degree of hearing loss in one ear and total deafness in the other.
Another option is a Bone Anchored Hearing Aid (BAHA), a surgically implanted device that uses direct bone conduction to transmit sounds from the affected ear to the normal one. Vibrations in the bones of the ear canal and middle ear stimulate the hair cells of the cochlea, boosting the ability to hear.
Call Audiology Associates of Holladay at (801) 272-1232 for more information or to schedule an appointment.
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Home Home Performance Multifamily
Perlita House: The First Passive House Building in Los Angeles
BY XAVIER GAUCHER
A version of this article appears in the Spring 2019 issue of Home Energy Magazine.
Click here to read more articles about Multifamily
A few years after I finished building what I thought was my dream house in France, I discovered the Passive House International (PHI) standard and became very frustrated that I hadn’t known about it earlier.
Why Passive House?
According to the latest climate scientists’ report, published in October 2018, drastic weather changes, ocean rise, more forest fires, and other consequences will occur if we don’t limit total global warming to less than 2°C. To achieve this goal, we need to change our ways of living now. According to climate scientists, the target is to reduce our CO2 emissions by 45% by 2030 and to reach carbon neutrality by 2050. The PHI standard that began to be developed in the early 1990s has proven to reduce a home’s heating-and-cooling demand by up to 90%, and to reduce up to 75% of the total energy consumption of buildings, depending on the climate. More than 80,000 buildings all around the world, in every climate zone—single-family homes, apartment buildings, office buildings, hospitals, schools, museums, and more—are built to the PHI standard. But this is still nothing compared to the several billions of new square feet built each year, and even less when you consider that there are approximately 120 million existing buildings in the United States alone.
Perlita House—after. (Xavier Gaucher)
So when communities that are really serious about meeting the international COP21 standards—the 21st United Nations Climate Change Conference in France in 2015, or Conference of the Parties (COP21)—discover the PHI standard, they have a clear and reliable path to reducing almost half of their carbon emissions by building or renovating every building to conform to that standard (45% of CO2 emissions are emitted from buildings). This is, for example, what Vancouver started to do a few years ago. New buildings are to be zero emission by 2030 and using PHI standards will help them get there.
Perlita Passive House
When I learned about the PHI standard, I did not understand why every single building wasn’t built to that standard. As a mechanical engineer, I wanted to get the training to help design and build houses using the standard. In 2014, I took the Certified Passive House Designer and Consultant training. And I decided that my next house would be a Passive House.
So when I moved with my family to Los Angeles, that was all I had in mind. In the summer of 2015, we found a house to renovate in the location we wanted (because the PHI standard works for retrofit as well as for new construction). And I set to work.
We have now been living in the Perlita Passive House—the first Passive House in the Los Angeles area–for a full 12 months, and I am now able to share real operational results. I can confirm that the PHI standard performs in this area as well as it does in all the cities that are adopting it around the world—from Brussels to Dublin, from New York to Vancouver.
First off, how is our house different from standard construction in California?
It has more insulation in the walls, the roof, and the floor.
It has fewer thermal bridges. This is done by making sure that the thermal envelope is continuous.
It has a very airtight envelope (blower door tested at 0.6 ACH50 maximum, as compared to an average of about 6 ACH50 for conventional new construction, equivalent to a 16-inch hole in the building envelope).
It has highly efficient windows with appropriate
shading.
It has continuous fresh air and exhaust ventilation to ensure proper indoor air quality (IAQ).
Perlita House—before. (Kirk Gerou)
All of these attributes enable our house to meet the PHI energy consumption criteria. These criteria are maximum heating demand 4.75 kBtu per square foot per year; maximum cooling demand 4.75k Btu per square foot per year, plus the dehumidification contribution related to the local climate (0 in our case); and maximum energy use intensity (EUI) 14.8 kBtu per square foot per year.
A simple but detailed energy modeling tool, the Passive House Planning Package (PHPP), helps you to determine the insulation R-value, window efficiency, air-conditioning system, and ventilation unit required to meet these criteria. Table 1 shows how the Perlita house compares to Title 24 California Code requirements with respect to R-value and ACH50.
Table 1. Perlita House and California Code
Los Angeles—Climate Zone 9
Title 24—2013
R-value walls
R-22*
R-15 + R-13 insulation
R-13 insulation
R-value floor
R-value roof
R-value window
Air Leakage, ACH50
≤ 1.0 for retrofit
6 approx.
(No requirement)
Our PHPP requirements were not far off the current Title 24 California Code requirements, and should lower our heating and cooling demand by 63%. (It is hard to tell precisely, since the monitoring system does not give a breakdown just for the HVAC unit; but we are close to our overall energy use goal, and our 1-ton HVAC unit does the job. So we are on track.)
The main differences between Perlita House and Title 24 were as follows:
We increased the required R-value a little for the roof and the floor and added an extra layer of insulation for the walls.
We installed high-performance double-paned windows and doors. The most difficult part was to find airtight ones, since the National Fenestration Rating Council air leakage test is optional.
We made the envelope airtight. While this was the most challenging part of the job, it also made for the biggest improvement over Title 24 requirements.
We installed an efficient ventilation system.
The overall additional cost was 3.6% more than normal construction, including the Passive House modeling and consulting fees and taking into account the savings from a smaller heating-and-cooling unit requirement.
However, it is critical to note that Passive House is not a typical cost-plus paradigm. If you take a typical building and simply try to make it a Passive House building—yes, it could cost more. But if you start from the beginning of the design process and fully integrate Passive House goals, on average PH can even cost a little less than standard construction (see Figure 1).
Figure 1. If you start from the beginning of the design process and fully integrate Passive House goals, the average cost can even be a little lower than standard construction. (Xavier Gaucher)
Living Well in a Passive House
During the Christmas holidays we stayed at some relatives’ house, and that’s when my wife, my son, and I realized the advantages of living in our Passive House for the last year. Unlike our relatives’ conventional house, our house isn’t cold when we get up in the middle of the night or in the morning. The HVAC popping on in the middle of the night does not wake us up; in our house we don’t even hear our small 1-ton heat pump, which barely ran during the entire winter or even during the summer unless it was over 100°F outdoors; and the upstairs does not get warmer than the downstairs. All three of us had forgotten those issues; it is amazing how well one adjusts to comfort!
After we moved into our new house, we had friends stay with us and our two large cats. As it happens, several of them were highly allergic to cats; they had expected to suffer and to have to take strong medicine. But not one of them experienced an allergic reaction. The only explanation is that the continuous ventilation required in PHI buildings provides a silent, but constant, fresh air supply that maintains a very high IAQ. With equal amounts (120 CFM50) of fresh air and exhaust air, we can always maintain our CO2 level way below 1,000 ppm, compared to standard-built homes, where it is common to regularly exceed 3,000 ppm.
Second layer of wall insulation before drywall. (Xavier Gaucher)
Another comfort benefit we are experiencing is that we no longer hear the city noises, thanks to our house’s airtight envelope, high-efficiency windows, and extra insulation. Even helicopters flying at night (ubiquitous in Los Angeles) don’t wake us up anymore.
Then every two months we receive our energy bill, and
we realize how well Passive House and net zero energy work together.
Integrating Solar, Going All-Electric
Renewable energy has been fully integrated into PHI standards since 2015, when PHI developed the primary energy renewable (PER) factor and added two new certification classes: Passive House Plus, roughly equivalent to net zero, and Passive House Premium, equivalent to carbon zero. The original Passive House standard without renewable energy was rebranded as Passive House Classic.
So on-site solar panels were not a requirement to certify our house, but we designed it to have an unshaded roof almost perfectly facing south for solar panel placement, since in California, starting in 2020, all new residential buildings up to four stories will have to be net zero (to produce at least as much energy from renewables as the building uses over a 12-month period). Our PHPP modeling called for ten panels to reach Passive House Plus or net zero for our 2,120 ft2 all-electric fossil-fuel-free house.
During the renovation process, we removed the gas line to the house, which was no longer needed. Induction cooking works better and is safer than gas; our heat-pump water heater works perfectly and cools the unconditioned basement which existed when we bought the house—perfect for wine storage. Using a heat pump for heating and A/C was cheaper than adding a furnace for heating alone. And our electric ventless clothes dryer works perfectly and was easy to install. So not only do we now not emit CO2, but we also have a healthier and safer house.
We also decided to get a small used electric car and calculated the need for four more solar panels to supply the electricity that our local commute of about 7,500 miles per year would require.
So we were looking at a solar array of 16 360W panels. Without enough historical data, and considering how much cooking we do and allowing a safety factor for house consumption, we added two extra solar panels to the ten required by PHI. Over the last 12 months (our solar panels kicked in on January 11, 2018), we produced 10,240 kWh (see Figure 2). On January 11, 2019, our electric meter showed that we had received from the grid 3,864 kWh and exported to the grid 5,095 kWh. We used 1,384 kWh for the electric car that we purchased in April, so this means that we used 7,575 kWh for the house, without paying any special attention to our usage or changing any of our habits. I suspect that much of the 20% difference between my modeling numbers and the actual figures is attributable to the fact that we did more cooking than we had anticipated, since we are enjoying our new kitchen space and entertaining often. I will be investigating our energy use further; I plan to start by finding an affordable monitoring system that takes into account the storage battery.
Figure 2. In one year, the Perlita Passive House generated more energy than was used in the home—including the power used to charge an electric car. (Xavier Gaucher)c
According to these numbers, the Perlita Passive House was net zero energy this year with only 12 solar panels, for an all-electric 2,120 ft2 house. Our final EUI was calculated at 12.1 kBtu per square foot per year. According to the LA Energy Atlas, developed by the California Center for Sustainable Communities at UCLA, the average energy consumption for single-family houses is 44.9 kBtu per square foot per year. This corresponds to an energy consumption almost 4 times higher than our Passive House, which means 4 times more solar panels to reach net zero. Looking only at buildings built after 1990, the average EUI is 33.4 kBtu per square foot per year, which is still almost 3 times higher and means 3 times more solar panels to reach net zero.
The EUI for buildings could be compared to miles per gallon for cars. The most energy-efficient gas car uses “only” one-third as much fuel as the worst gas guzzler (18 mpg versus 55 mpg for mixed city and highway use). When CO2 emissions for buildings are higher than CO2 emissions for cars, we need to start looking at building efficiency much more seriously than we do now.
For various reasons, including the fact that it is required for the Living Building Challenge certification we are doing, in addition to our Passive House certification, we installed a 13.5 kWh storage battery in mid-April. The battery allows the house to be off-grid about 70% of the time, so I looked at what it would take to make it 100% off-grid. In order to cover that 30% gap, we would need ten more solar panels and two additional storage batteries. After making that calculation and estimating the corresponding cost, I was very happy to have to pay at present only $11 a month of minimum charge to my utility company. It also shows the challenge the utility companies are facing while switching to the fossil fuel free grid we need, especially in terms of storage capacity. At present, there is no return on investment for electricity storage batteries. This will probably change as we move more and more toward an all-renewable grid, and as time-of-use peak rates continue to increase. For now, the best batteries are comfort storage batteries—that is, Passive House buildings. Improving building performance is essential if we want to see a carbon-free world.
I know that the Perlita Passive House won’t save the world, but I hope our project is inspiring as many people as possible to start making PHI the new construction standard in California. This is what the amazing PHI community of about 10,000 people from around the world is doing every day.
In terms of changes that our society, which includes each one of us individually, needs to make, changing the way we erect and renovate buildings is probably the easiest. We already have the solutions that bring more than just comfort and very low energy bills. PHI makes economic sense; it creates jobs and gives those jobs a new meaning for contractors building and renovating houses in the field; and it gives a meaning to those “sustainable” and “green” designations that I see too often without really understanding what they mean.
What’s next? Today, building operation represents 90% of the CO2 emissions in the building life cycle assessment, while less than 10% comes from building construction. However, when you reduce emissions related to operation by 75%, the emissions related to construction—mainly from construction materials—suddenly represent one-third of building emissions. So the next step for our industry is to reduce CO2 emissions from building construction—which will also help to conserve our limited natural resources. Two examples: The cement industry alone accounts for 5% of the world’s total CO2 emissions; and available natural resources won’t be sufficient to manufacture all the solar panels and storage batteries we will need, if we don’t significantly increase our buildings’ efficiency.
To learn more about the Perlita Passive House.
I am returning to France in three years. However, my goal before I leave is to begin as many Passive House buildings in the Los Angeles area and in California aspossible, and to share my experience of Passive House building with architects and designers. Vancouver has set a record that I would like to see us beat. Vancouver had one single-family Passive House in 2015; by the end of 2018, it had 1,100 permitted Passive House buildings. Can we beat that in Los Angeles? The second Passive House in the Los Angeles area is already finished. Who is next?
Xavier Gaucher is a Certified Passive House Consultant and a board member of Passive House California.
Climate House: Passive House as an Opportunity
By Andreas Benzing
Designing a new building in a flood zone can be a rigorous challenge but also an opportunity. In New York, Superstorm Sandy left behind devastated communities in low-lying coastal areas of Long Island. Some residents ...
Passivhaus 101: Sustainable Architecture from the Inside Out
By Wolfgang Frey
This article discusses the Passive House (PH) as an example for sustainable architecture. It defines what a PH house is as well as how it uses shading, ventilation, and solar power efficiently. Originating from the ...
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Chief Minister N Biren inspects Nambul river, plants tree saplings
Biren said the water treatment plant at Mongsangei will prevent toxic water from flowing into the Loktak Lake.
By Lelen Vaiphei | Updated on: Aug. 27, 2020, 11:58 p.m.
Manipur CM Biren plants sapling by the Nambul River (PHOTO: DIPR)
Manipur Chief Minister N Biren Singh on Thursday said that the Nambul river can regain its natural state if sewage and other wastes from localities can be stopped from being dumped into the river.
Under the Nambul Rejuvenation Project with an estimated cost of Rs 95 crore, a sewerage pipe near the river banks will be installed, wherein it will carry the wastes from the localities to the water treatment plant at Mongsangei, the chief minister said.
Biren was speaking to the media after inspecting the condition of the river as a part of the programme held for planting tree saplings alongside the river from Waheng Leikai to Keishampat Junction. Biren said that the water treatment plant at Mongsangei will prevent toxic water from flowing into the Loktak Lake.
The chief minister also mentioned that the peculiarity of the Nambul river is that it flows through the middle of the city. Since 2004, efforts have been made to develop and maintain the river and the result and changes can be seen now, he said.
The work to plant Bougainvillea which thrive well with the soil of Manipur has been taken up on both sides of the river to attract tourists. The flowers will be planted from Thongnambonbi to Keishampat and it will continue further at the remaining river banks of the city, he added.
Commenting on the progress of Nambul River Rejuvenation Project, Biren said, “The project is still going on and it will be wrong to assume at the moment that the project is successful”.
Responding to a query from the media regarding the delimitation issue in the state, the chief minister said that the government as the representative of the people made it clear that delimitation should be conducted only after conducting a new census.
Forest and Environment Minister Awangbou Newmai said if the river banks in the city are beautified and maintained properly, it will make the city more beautiful. It will also create awareness to the people on the government’s plan to save the river, he added.
To prevent pollution of rivers, the state government in March 2019 launched the project for rejuvenation and conservation of Nambul river under the Nambul River Conservation Plan, (NRCP) of the Union Ministry of Environment, Forest and Climate Change, he said.
In a bid to save Nambul river, a boat rally was also conducted in the river stretch from Imphal to Bishnupur district on July 2 this year.
Deputy speaker of Manipur Legislative assembly, K Robindro, deputy chairman of State Planning Board S Rajen Singh and other government officials were present at the occassion.
It may be recalled that the Imphal Free Presshad strongly raised concern over the state of the river in its report dated July 10, 2020.
Can Manipur save its dying Nambul River?
First Published:Aug. 27, 2020, 7:47 p.m.
CM Biren,
Nambul Rejuvenation Project,
Nambul river,
Lelen Vaiphei
IFP Reporter, IMPHAL, Manipur
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Meghalaya government accused of poor COVID-19 management
AICC Secretary and party spokesperson Zenith Sangma said there was absolutely no roadmap in handling the Covid situation in the state..
By NNN/Shillong | Updated on: Sept. 17, 2020, 8:24 a.m.
Shillong, Meghalaya (Photo: Facebook)
The opposition Congress has slammed the NPP-led Meghalaya Democratic Alliance (MDA) government for its alleged failure in fighting against the COVID-19 pandemic while also alleging that despite the restriction, people representing business houses from outside are allowed to sneak into the state to have regular meetings with Chief Minister, Conrad Sangma.
AICC Secretary and party spokesperson Zenith Sangma informed that there was absolutely no roadmap and there is a lack of coordination between the government and the district administrations, in as far as handling the COVID-19 situation.
“The COVID pandemic is a burning issue across the globe and because of this everybody is living on the edge but in the context of Meghalaya, what I could see is a complete failure of the management in fighting against Coronavirus,” said Sangma who is also the MLA of Rangsakona.
"The government has turned a deaf ear despite repeated requests to come up with proactive measures, so that the state will be able to handle any kind of challenges and unforeseen situation due to the pandemic", he said while adding, "but all this is not being spelled out properly by the government of the day".
The Congress spokesperson said that different administrations are having different ideas as far as fighting against the pandemic.
Zenith Sangma also accused the government of allowing people representing business houses to sneak into the state. “(At a time) when outsiders are not allowed to come to the state but certain people representing business houses could sneak into the state and the state secretariat to have regular meetings with the CM. How can they allow this to happen?” he asked.
He then requested the State government to look into the loss of several lives because of other diseases "due to medical diversion", while pointing to the increased maternal and infant mortality rate in Meghalaya.
The AICC Secretary also suggested the need to have temporary or make shift centres to collect samples, as people are reluctant to visit the hospitals for the same and that the government should also provide relief to people who are not in a position to earn their daily bread, due to the pandemic.
First Published:Sept. 17, 2020, 8:24 a.m.
shillong,
meghalaya government,
meghalaya COVID-19,
meghalaya congress,
NNN/Shillong
Newmai News Network, Shillong, Meghalaya
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How To Leverage The New Google Search Console (And Understand It)
Home // Blog // How To Leverage The New Google Search Console (And Understand It)
January 22, 2018 By John E Lincoln
News from Google tends to make waves.
Its latest announcement is no exception.
Google recently unveiled a new Search Console with expanded features and reports, and I’m offering a full review of the new features below.
Google’s New Search Console
News of the new search console first began to spread back in August, when Google announced its rollout of a beta version of the new console to a select number of users.
On January 8, Google again released an announcement. This time, to tell us that soon everyone will be able to take part in the fun.
After months of testing, Google is releasing four of the most popular features of the new console to the public.
Google says the new Search Console reports provide “more transparency into Google’s indexing, stateful two-way communications between Google and website owners to help resolve issues faster, and a responsive user-interface.”
So what will you find in the new Console? Four new, in-depth reports based on 16 months of website data.
The New Google Search Console – Search Performance
If you’ve used Search Analytics, the new and improved Search Performance should sound familiar.
The Search Performance feature builds on the former by including more in-depth data about how your site performs in search results, such as how often your site appears, its average position, click through rate, etc.
Google notes that by using this information, you can work to improve by:
Monitoring how your search traffic changes over time, and what queries are most likely to show your site
Improve your mobile targeting by gaining insight into which queries are made mobile
See which of your pages have the highest and lowest click through rates
The new report shows 16 months worth of data, enabling you to see a much longer range of information and identify any year to year trends or differences.
The New Google Search Console – Index Coverage Report
The existing search console already offers a limited index report, but the new version offers much more in-depth information and data.
The index report shows you which of your pages have been correctly indexed and identify any potential issues with pages that couldn’t be indexed.
Now, the system will automatically alert you when there’s an indexing error and help you get to the bottom of it.
When you’re alerted to a specific problem, you will be able given the page details and a link to diagnostic tools to better understand what went wrong.
Because these errors often require a specific skill-set to fix, the updated index report also includes a share button so you can easily share the report with members of your team.
Once you’ve worked to resolve the issue, you can alert Google. Google will then act faster to recrawl and index your site to make sure your fixes were effective.
Going forward, there are a few scenarios to be on the lookout for.
First, if you notice a sudden spike in indexing errors, it could point to a change in your template or a sitemap that includes blocked URLs.
If you see a drop in indexed pages that isn’t due to errors, it could potentially mean that you’re blocking access to your pages.
And lastly, if you see a significant amount of pages that aren’t being indexed, you should look into your excluded URLs to make sure you haven’t excluded any that you want indexed.
The New Google Search Console – AMP Status
Google’s been big on accelerated mobile pages (AMP) for a while now, so it makes sense that it now has its own dedicated feature on the new search console.
The new console allows you to monitor your AMP performance, including how your pages are displayed and details on any specific error or warnings.
Similar to the index report, you’ll be shown all issues found by Google and given insight into which pages were affected, how to fix it, and how to notify Google once the issue has been addressed.
Google will sort all issues by a combination of severity, validation and number of affected pages, with the most pressing listed first. They also note that while AMP pages with warnings can still show in Google search results, they may not appear with all AMP features.
The New Google Search Console – Job Postings
Have job openings? Google now has a place for them.
Google for Jobs – the company’s answer to sites like Monster and Glassdoor – was announced by the company last year and available only in certain locations.
Now, you’ll be able to list your job openings through the search console and monitor their performance.
The report will tell you any potential errors in your postings, and you will be able to monitor any error spikes or missing job postings.
Similar to its other report functions, you will be able to alert Google that your postings are ready to be revalidated once the errors have been fixed.
What Does Google’s Search Console Mean for Business?
The newest installment is an obvious upgrade for marketers.
Perhaps the biggest improvement is the transparency offered in the new reports.
While much of this data has been limited in the past, webmasters will now have access to detailed reports and error messages regarding indexing and search performance.
A less emphasized but no less important upgrade is the ease of communication the new reports allow between team members. A simple share button will allow for clearer communication and faster fixes.
As the new console continues to roll out and Google adds more features from the old console, the old version will stay live.
For now, Google states that both versions will continue to live side by side and webmasters will be able to access both through the navigation bar.
As for the future, Google’s isn’t stopping with these four features. Google plans to roll out more features throughout the year.
Get Started with Google’s New Search Console
The new Search Console represents a big step towards transparency with Google, and as any SEO knows, that’s a step in the right direction.
Time will tell the how these changes affect campaigns going forward, but for now, stay tuned. There’s more to come.
Michelle Draper, Chief Marketing Officer at Silicon Valley Bank
YouTube Rolls Out New Search Results Page – Ignite Friday
New Study Says Google’s SMITH Algorithm Beats BERT
Google Launches Question Hub and More Marketing News – Ignite…
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Shortages Force Closing Of Illinois Pot Dispensaries
CHICAGO — Several Illinois recreational marijuana dispensaries were closed Monday, with some owners saying strong demand has caused a shortage in supplies and staff exhaustion.
The legal sale of recreational cannabis began Jan. 1 in Illinois, with customers spending about $3.2 million on the first day and more than $10.8 million over five days. By comparison, Michigan, which made recreational marijuana legal on Dec. 1, generated $3.1 million in the first two weeks of sales.
Neal McQueeney of Midway Dispensary in Chicago said the shop stopped selling recreational product Sunday and doesn’t expect to resume sales until Friday.
“The demand was huge,” McQueeney told the Chicago Tribune. “We knew we were going to run out. It was a matter of when, not if.”
He said that like other stores that have stopped recreational sales, Midway is still open for medical patients.
Product shortage is not the only reason some dispensaries have shut down. Jason Erkes said Cresco Labs shut its Sunnyside shops in Chicago, Rockford and Champaign to all customers to “reset” and give his staff a break after working five consecutive 14-hour days.
“There are no product supply shortages,” Erkes told the Chicago Sun-Times . ”Just a shortage of state-approved employees to help efficiently service the hundreds of people that have been showing up every day to make their first legal cannabis purchase in Illinois.”
One Chicago dispensary was shuttered after police said it was burglarized over the weekend. MOCA Modern Cannabis on the city’s Northwest Side was hit by thieves overnight Sunday, police said, resulting in the loss of an undisclosed amount of cash.
Smart Approaches to Marijuana president Kevin Sabet said the burglary was predictable.
“This is a wake up call that legal marijuana isn’t all rainbows and unicorns, that these store are detriments to the community and serious consequences often come with them,” said Sabet, who opposed Illinois’ push to legalize pot sales.
PrevPreviousNews Around Illinois – January 7, 2020
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Telemedicine Sounds Great, But There Are Barriers, Too
As soon as COVID-19 hit, there was a massive jump in telemedicine visits. A Centers for Disease Control study found that in March 2020 there was a 154%…
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Founder Testamonials
What is ILT Academy?
Join the Ecosystem
Making St. Cloud an Entrepreneurial Hub
Making St. Cloud an Entrepreneurial Hub https://iltacademy.io/wp-content/uploads/sites/3/2020/02/Making-St.-Cloud-an-Entrepreneurial-Hub.jpg 1024 768 ILT Academy ILT Academy https://iltacademy.io/wp-content/uploads/sites/3/2020/02/Making-St.-Cloud-an-Entrepreneurial-Hub.jpg November 21, 2019 March 5, 2020
When seasoned innovator Nick Tietz wanted to start his next venture in Minnesota he actively looked outside the Twin Cities. “I wanted to find a spot where I could plant my next idea company in an area where there was less competition, but also in a spot where people would want something like a company that generates new ideas to exist.”
Tietz visited multiple other locations in Minnesota and the Dakotas but eventually settled on St. Cloud for his new company ILT Studios. “What we’re really committed to is systematizing innovation and entrepreneurship to help ideas succeed and help them reach their maximum growth potential.”
“It became really apparent that there’s a desire in this area for this to happen, but the challenge is how do you turn that on and how do you really get it going?”
A number of St. Cloud residents and advocates are trying to answer that question and turn the city into a true entrepreneurial hub.
Making a city or region into a startup or entrepreneurial hub is a common conversation these days throughout the country. There are conferences, websites and organizations all designed around the concept of ecosystem building and how to do it. In fact, we talk about it quite a bit in the Twin Cities.
As to why different cities or areas are trying to build up these hubs, it often comes back to some common major themes, particularly when it comes to economic development.
“From my perspective it’s vital to business health,” says Patti Gartland, the President of the Greater St. Cloud Development Corporation, or GSDC. “It’s vital to have that entrepreneurial ecosystem within your business environments, it’s really paramount to being able to sustain and grow your businesses.”
Tom Grones, the founder and current Chairman of the Board of GeoComm (a St. Cloud based provider of public safety GIS systems) agrees and joined the GSDC’s Business Startup /Entrepreneurial Ecosystem sub-group. He shares first-hand experience of how a startup can affect an area such as St. Cloud. “My company has, over the course of 25 years, redirected the lives of a lot of talent here in the community,” says Grones. “We have a lot of talent. We have three major universities here. My company, our needs were to keep that talent here. We were able to be successful in redirecting talent that would’ve otherwise bled away. We’ve provided an opportunity for local young people as well as young people who have come from out of town to the universities. We’ve helped begin careers for them here in St. Cloud, kept them here, had them grow families. It’s just part of sustaining a quality of life here that we think is exceptional.”
Continue reading the full article at Starting Up North
By Stephanie Rich. Originally published at Starting Up North on November 21, 2019.
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Our Major acquisitions are focused on building new capabilities as well as making up deficiencies in the inventory. With Defence Procurement Procedure-2013 coming into effect, indigenization will get due impetus. The Army also carried out alignment of the acquisition structures by streamlining the evolution of General Staff Qualitative Requirements (GSQRs), establishment of a Contracts Negotiation Committee (CNC) Cell and inclusion of Integrated Financial Adviser (IFA) Capital for delegated financial powers and strengthening of the Request for Proposal (RFP) Cell. All these measures have made the system more robust and efficient.
Mechanised Forces: Modernisation of the mechanized forces is underway to meet the requirements of the future battle field. Upgradation of aspects of in-service equipment like night fighting capability, modern fire control systems and better power packs has been the thrust area. Concurrently, the indigenous development of future combat vehicle platforms is also being progressed.
Artillery: Procurement of Artillery equipment is focused on conversion of equipment to 155 mm caliber, enhancing surveillance capabilities and acquisition of long range vectors.
Infantry: Modernisation of the infantry soldier is aimed at enhancing lethality and providing individual protection. Procurement of modern Assault Rifles, Carbines and LMGs alongwith Bullet Proof Jackets and Ballistic Helmets is underway.
Army Air Defense: The Corps of Army Air Defence is taking major strides in upgrading its gun and missile systems. A number of quality upgrades and inductions which are in the pipeline would replace the existing vintage equipment.
Common Equipment: In addition to acquisitions specific to different arms, induction of High Mobility Vehicles, Materials Handling Equipment and critical Rolling Stock for rail movement are in the pipeline. Modernisation of logistics installations with state of the art warehousing facilities, retrieval and accounting systems is also underway.
Synergy with the DRDO: Army has enhanced its interactions with Defence Research Development Organisation (DRDO). Projects addressing ammunition needs are being given priority so that we can move towards self reliance.
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Home News These Guys Discovered One Weird Trick for Building a Clickbait Empire
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These Guys Discovered One Weird Trick for Building a Clickbait Empire
by David Hudnall
Chris Kolmar (left) and Nick Johnson
Four years ago, Chris Kolmar and Nick Johnson were working in the Bay Area for Movoto, an online real estate brokerage that matches buyers with agents. Kolmar, a twenty-nine-year-old computer geek with a brain for algorithms, was Movoto's director of marketing. Johnson, thirty-nine, an affable former sports reporter, handled media outreach. Their directive was to drive traffic to the Movoto website so that people could connect with agents, buy houses, and score Movoto finder's fees.
Search-engine optimization was key. Movoto needed to appear prominently when people searched for "realtor Detroit" or "houses for sale Tucson."
But the web was also in the midst of a sea change. Facebook had become the Internet's home page. Sites like BuzzFeed were breaking traffic recordsand raking in truckloads of cashby specializing in the kind of viral ephemera that Facebook users share widely.
What if, Kolmar wondered, Movoto applied BuzzFeed's strategy to Movoto? Businesses creating original content as a way of marketing themselves wasn't a new concept, of course. But the Facebook paradigm held vast potential. A post could reach millions in a single day.
If Kolmar could produce content and get it to go viral, that would translate into big traffic for Movoto's siteand, in theory, big bucks for Movoto.
"The challenge was how to make real estate interesting," Kolmar says. "And we didn't have a team of journalists who could compete with the big media outlets on real estate news. So we started writing these blog posts about things that we knew there was an audience for: what the fictional value of Batman's house might be, or how much Harry Potter's castle would cost."
It soon occurred to Kolmar that posts about neighborhoods, cities, and states were a natural fit. So Movoto started cranking out titles like "These Are The 10 Best Places To Live In Alabama." The methodologytossing census information, crime rates, tax rates, weather conditions, and a few other factors into an algorithm and writing up whatever it spit outwouldn't pass muster at a research lab, but that wasn't the point.
"We figured out pretty quickly that if you tell the people in a city that their city is a top-ten best place to live for something, they'll click on you," Kolmar said. "And often, if you send that link to a media outlet in that city, they'll do a story on it."
Kolmar and Johnson had stumbled upon a dark truth about media in the Internet age: Establishment news outletsTV stations, radio stations, even newspaperswere as desperate for traffic as Movoto was. In this beleaguered media environment, a half-baked Movoto "study" often rose to the level of news. If something smelled vaguely viral, journalists would happily gobble it up. Few editors or reporters seemed to care about the methodology behind Movoto's findings, or even that Movoto was a for-profit enterprise.
Traffic to the Movoto blog skyrocketed, from two thousand visitors per month in 2011 to eighteen million in 2014. But there was a problem.
"The traffic was all crap," Kolmar said. "The people weren't buying houses."
Kolmar and Johnson had become wizards at getting eyeballs, but their audience was mostly clickbait rubberneckers. And though creating all that content was cheap, it wasn't free. Movoto wasn't seeing a substantial re- turn on its investment.
In October 2014, Movoto was purchased by a large Japanese corporation and soon cut the cord on Kolmar and Johnson's viral-content strategy.
Kolmar relocated to Durham, where his wife is a pediatrics resident at Duke Hospital. Johnson and his fiancée later followed them to the Triangle. They wanted to continue working together, building on the knowledge of regional virality they'd acquired at Movoto but in an environment free of the burden of having to sell something.
In other words, a clickbait site.
On a Thursday morning in January, I drove to the Chapel Hill home of Johnson and his fiancée, Kim. Located in a woody subdivision, their place doubles as the de facto base of operations for Kolmar and Johnson's new venture.
Kolmar typically works from his home in Durham (he has a new baby) or Bull City Coworking, but he'd stopped by, in Duke cap and hoodie, to give me an overview of the operation. Kim, who helps out part-time, was in the living room, half watching TV, half working on her laptop. Johnson, a UNC cap on his head, was in a Post-it-filled zone off to the side of the living room, behind a messy desk with a couple of large monitors on it. A Pandora station was churning out earthy jams: Rusted Root, Dave Matthews, an interminably long Counting Crows song. Their new company, founded last May, is called Chasing Chains, LLCa frisbee golf reference.
"Regional infotainment" is the phrase Kolmar and Johnson use to describe Chasing Chains' two sites, HomeSnacks and RoadSnacks. Though that phrase may be unfamiliar, the content it refers to is likely queued up on your Facebook feed at this very moment. Maybe a friend from college just shared a post about the "50 Best College Towns To Live In Forever" that featured your alma mater. Or a restaurant where your cousin works was named one of the "20 Best Restaurants in Charleston Right Now."
If you click on these links, they sometimes lead you to well-established websites, either old school (Travel & Leisure) or new (Thrillist, Huffington Post). Like Kolmar and Johnson, these outlets have discovered that innate hometown pride can be soaked up and wrung out as advertising dollars.
Just as often, though, the "10 Reasons North Carolina Is The BEST State" post leads you to some site you've never heard of before. Somelike WalletHub, NerdWallet, and SmartAsset (why are the two words always smashed into each other?)are personal finance websites that publish clicky, regional "studies" to boost their exposure and collect consumer data. Others, like HomeSnacks and RoadSnacks, are pure page-view plays, dependent entirely on ad revenue.
Only In Your Stateprobably Kolmar and Johnson's closest competitorfalls into the latter category. It has huge reach: more than five million fans across its state-themed Facebook pages. Brian Warner, who owns and runs the site, told me he started Only In Your State because he wanted to highlight cool places and interesting small businesses.
"I just think it's awesome when we hear from businesses that tell us their sales exploded after we called them the best donut shop in their state," Warner says.
But how does Warner, who lives in Los Angeles, have any idea what the best donut shop in Georgia is? He says he has a team in place that manages content for individual states. But he's unwilling to divulge how many employees he has or how they're paid.
Kolmar and Johnson are more open about their business. At Johnson's house, I asked them to take me through the life of one of their posts. They chose "These Are The 10 Most Boring Cities in South Carolina."
Kolmar takes pride in the fact that their findings are not plucked from thin air but rather are the result of a pseudoscientific data mine. To determine the boringness of cities in a given state, Kolmar created an algorithm that examined the percentage of the population over thirty-five years old, married population, population with kids, and population over sixty-five. The higher these numbers were, the more boring the place was.
Johnson purchased three Facebook ads targeting users who live in the cities that made the list, as well as users who "like" South Carolina on Facebook. Each ad used a different picture. After a few hours of the "suggested post" being delivered to Facebook feeds, Johnson checked to see which ad was attracting the most clicks and shares. He then shut off the others and increased the ad buy on that post. In the other room, Kim was blasting South Carolina media with pitches, drawing from an organically assembled spreadsheet containing more than two thousand media contacts across the country.
Johnson checked Chartbeat to see how many users were currently looking at the post: twenty-six.
"Twenty-six at noon is pretty good," Johnson told me. "If it continues at this pace, by three p.m. there could be about fifty on it, and by the time people get home from work, maybe a hundred. And if you get hot with sharing after work, you could have as many as six hundred on it by midnight, and if you can get to there, you're pretty much guaranteed one hundred and fifty thousand views"Kolmar and Johnson's general benchmark for a viral post.
A few days earlier, while browsing the HomeSnacks site, I noticed that the thumbnail for a post called "If You're From North Carolina, This Will Be The Most Jaw-Dropping Thing You See Today. Guaranteed" had a computer-drawn marker circling some indiscriminate object on a beach, with an arrow pointed at it. But when I clicked, it was just a four-minute video with aerial shots of picturesque North Carolina scenery. There was no payoff for the beach mystery. Despite this, it had attracted over seven hundred thousand page views.
The videos they were publishing the morning I visited also had arrows and circles, occasionally a "Wow!" written somewhere on top of the photo. What was with the drawings?
"It's so spammy, and I hate it," Johnson says. "But if I ran those videos without the arrows or the 'LOL,' probably about half as many people would engage with it. We could say, 'This is a great video, it'll break your heart, it's beautiful,' and with no arrow maybe five percent click. People don't care. But if you're like, 'This will blow you away,' and you circle something or throw an arrow on it, they come to it."
Does HomeSnacks see diminishing returns on its traffic after people realize they've been misled?
"That's a concern, for sure," Johnson says. "I think about that. But the thing is, right now we're so new that we don't really have a brand. We're just another site you see on Facebook that you click and then read real quick."
"They're the biggest sharers on the Internet," Kolmar says. "Generally speaking, if they don't care about it, we don't write about it."
"But it's surprising what they seem to care about," Johnson chimes in. "I live with a woman over the age of thirty-five"his fiancée, Kim"and I'm always trying to quiz her on ideas I have. I haven't been able to figure out a pattern."
From the living room, Kim shrugs. "Every day is an interesting anthropological experiment," she says.
"Like, you'd think a 'best places to raise a kid' post would do well to women over thirty-five," Johnson says. "But that's not been our experience."
In fact, they found that Facebook users were starting to grow tired of hearing about top places to live.
So they launched a new site, RoadSnacks, to explore the darker side of "regional infotainment"hence the "boring" and "dumbest" posts. They've done a series of negative concepts for each state: drunkest cities, most stoned cities, douchebag cities, ghetto cities.
An early HomeSnacks post about the best cities in Florida netted only twenty thousand unique page views. "But then we flipped it on the RoadSnacks site and did the worst cities in Florida, and that got three hundred thousand views in a week," Johnson says. "Right now, nine times out of ten, the traffic is better for the negative stuff than the happy or exciting stuff."
This approach is a double-edged sword, however. Earlier this year, RoadSnacks ran a post called "These Are The 10 Worst Chicago Suburbs." Kolmar's algorithm determined that the number-one spot belonged to a village called Harwood Heights. The post caught fire on Facebook and was picked up by the Fox and ABC affiliates in Chicago. The residents of Harwood Heights took it personallyso personally that the
Chicago Tribune did a story about the response, which included criticism from the school superintendent and the mayor.
"My thing is, I don't think the mayor of Harwood Heights should give a shit that RoadSnacks did a post about Harwood Heights," Johnson says.
Each post, Kolmar points out, has a note up top stating that it is "opinion based on facts" that is "meant for infotainment." In other words, it shouldn't be taken seriously.
"We clearly say we're not an authority," Kolmar says.
Still, this episode hits on an interesting point about the relationship between the traditional news media and clickbait sites.
A quick scan of my INDY email account shows that WalletHub has sent me forty-two pitches since the beginning of this year. Possible story ideas include a study about 2016's best cities in which to celebrate St. Patrick's Day and one about 2016's best cities for an active lifestyle. It's tempting. For an overworked reporter trying to hit a story quota, an "A study has found" post is like being handed an umbrella in a rainstorm. Clickbait studies are even more appealing because they're tailor-made to garner clicks.
So click-hungry news operations take the bait. The Triangle Business Journal, a generally reputable publication, aggregates WalletHub and the like on a near-daily basis. The TBJ may be the worst local offender, but we're all guilty. Virtually every local media outlet, including the INDY, has at some point indulged these lists.
The problem is, these are not legitimate news stories. They're cynical traffic grabsand cash grabs, too. The purely capitalistic dynamics here are plain to see.
Even Warner, the founder of Only In Your State, flat-out told me that his goal was to get to a point where his site could strike deals with entertainment destinations in which they paid him to be included on his site's lists.
Johnson says he is regularly surprised by the degree to which HomeSnacks and RoadSnacks posts are covered credulously by the media.
"The only authority we have is the authority [news outlets] give us," he says. "Why is the Chicago Tribune doing a story about our post? I mean, it's RoadSnacks-dot-net. We're not even a dot-com."
Despite being a relatively tiny businessjust Kolmar, Johnson, Kim, and some freelance writersChasing Chains nevertheless attracted seven million unique visitors to its sites last month. By comparison, The News & Observer's marketing literature indicates it draws 2.2 million per month.
They're not buying Rolexes yet, though. Kolmar showed me Chasing Chains' income statement for May 2015 through December 2015its first eight months in business. The biggest expenses were buying Facebook ads and paying writers (they pay based on the post's performance). All told, revenuesall from web ads, mostly Google Adsense and Taboolawere $163,000. Their net income was $55,000.
"But with six or seven million people a month coming to our site, we should be making more money than we are," Johnson says.
To further complicate things, their current business model will likely soon be outdated.
"Our current strategy works right now, but it's not going to last," Kolmar says. "The ad spends are getting more competitive. And Facebook could change its algorithm at any point, which would alter our traffic structure. So we have to diversify how we make money. It's just a question of what direction to take."
Consulting is one possibility. "We're very good at getting a lot of people in one region to see the same thing in one day," Johnson says. "Which is a good skill to have, and I think there are companies that would pay us for that insight."
In the meantime, HomeSnacks and RoadSnacks are beginning to bump up against the limits of regional infotainment.
"We've kinda run through a lot of the good topics alreadyfattest, laziest, hardest-working, boring, redneck, whatever," Johnson says. "You know, can you tell people, 'These are the most redneck cities in North Carolina,' and then the next year say, 'These are the most redneck cities for 2017'? I think we're still trying to test the limits of what people are willing to read."
Kolmar told me that what he'd really love to do is turn the sites into more journalistic enterprisessomething closer in spirit to Atlantic Cities.
"I think Nick and I, we think of ourselves as good humans, we want to balance our karma out," Kolmar says. "And we really do have a passion for local news. I wish we had the money to do more original reporting and original videos, on-the-ground stuff about Durham restaurants and things like that. Unfortunately, that's not what the Internet wants."
This article appeared in print with the headline "One Trick for Building a Clickbait Empire."
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Profile of Seth Grimes
News & Commentary Posts: 213
Seth Grimes is an analytics strategy consultant with Alta Plana and organizes the Sentiment Analysis Symposium. Follow him on Twitter at @sethgrimes
Articles by Seth Grimes
posted in May 2008
Misunderstanding Open Source
Richard Stallman announced the GNU Project in September 1983. Eric S. Raymond published the first version of The Cathedral and the Bazaar in 2000. IDC estimated a year ago that worldwide revenue from standalone open source software reached $1.8 billion in 2006, projecting a compound annual growth rate (CAGR) of 26% from 2006 to 2011. That's revenue, not the presumably much higher avoided cost of closed source alternatives. So why are open-source fundamentals still so widely misunderstood, inc
From Text Analytics to Data Warehousing
IBM recently posted a quite nice page on extracting business value from "unstructured" data. The premise is that because much valuable business information originates in "unstructured" form, you need to look at text analytics as a technology that can unlock value. And naturally, if you already have a BI program and a data warehouse, you'll want to explore integrating text-sourced information into your existing data-analysis infrastructure.
A Visualization is Worth a Thousand Words
The New York Times publishes exceptional visualizations. A couple this week stand out: "All of Inflation's Little Parts," graphing the average American's spending by category, and a map of the human "diseasome" that supports the article, "Redefining Disease, Genes and All." What distinguishes these visualizations is their success at communicating relationships along multiple data dimensions.
What BI Practitioners Can Learn From Operations Research
Growing interest in analytics and the trend toward automated decision making will lead the business intelligence crowd toward the mix of mathematical and statistical techniques used by operations researchers.
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RSBANDBInformer! — RuneScape Newspaper Articles from RSBandB
Alex’s Analysis – 20 Years of Quests
posted by Alex 43 on 9th January 2021, at 3:15am | Discuss Article
Runescape’s 20 years old now. Started in 2001, and now it’s 2021. That’s 20 years of quests and lore and development and immersion into a vast populated game world. A world that is full of quests! And man, do I have stories to tell about the stories in this story-based game!
As a guy who’s done all the quests and gotten my Quest Cape, the majority of them done the day of release, I will…
… wait, hang on one sec. I can’t talk about quests looking like this. I need to make myself properly tangible! One sec while I get myself properly geared up…
Right. Anyways…
As a guy who’s properly and legitimately earned his MASTER Quest Cape, I’m going to talk about the 20 year evolution of quests in Runescape! Because yup, the quests of Runescape have an evolutionary process beyond their story. It’s not just the advancement of events and the game world, but also that of the storytelling capabilities of the folks at Jagex. I’ve been playing the game for 20 years, and I’ve watched the company grow from a simple Java-based garage-built game to an entire company that can afford their employees daily fresh fruit and health care.
And what a ride it was.
Let’s go back to the days of Runescape Classic and the original few quests. Cook’s Assistant, Sheep Shearer, Doric’s Quest, and Romeo and Juliet. These are some of the most classic of quests the game’s got. The years have seen many overhauls and updates to these quests; callbacks, reworkings, and even entire substitutions. But at their roots; they were the most simplest of quests.
Cook’s Assistant involved you giving egg, flour, and milk to a cook. Sheep Shearer involved you giving 20 balls of wool to a farmer. Doric’s Quest involved giving copper, tin, clay, and iron ore to a dwarf. Romeo and Juliet involved giving cadava berries to an apothecary. … that was it.
Why so simple? Because that was the extent of the technology back then. We didn’t have item banks, and each NPC could only interact with a single player at a time. This meant that players often had to wait for an NPC to become available to talk with, and more than often, there were multiple instances of the same NPC to help mitigate that limitation. It wasn’t a lack of creativity; it was merely the most a quest could possibly possess.
Next up came some boss-styled quests like Vampire Slayer, Black Knight’s Fortress, Demon Slayer, and the Restless Ghost. At the time, players had such low combat levels that city guards were a legitimate threat to most. They had to be; they were responsible for stopping players from PKing each other. Yeah, world-wide PKing was a thing back then too; the wilderness wasn’t conceived. Fudge, I could talk about a lot of things in the RSC days…
Anyways, by introducing these quests where players had to fight a relatively difficult NPC, a drive to keep on playing and training welled up, and soon players started getting so strong that very few NPCs in the game posed any sort of threat to them. They became respected and prestigious, and thus were a great success in helping Runescape’s popularity increase.
The Gowers didn’t stop there, though. They continued adding quests both to give players something to do, as well as push their own limits on what’s possible. They added Goblin Diplomacy to introduce the idea of using dyes and coloring to solve an item-based puzzle. They added Shield of Arrav to have players team up and cooperate with questing. As the economy started to blossom, they added Pirate’s Treasure to help lower level players gain a fair bit of wealth to help them get properly started.
And then came Dragon Slayer. The ultimate quest (at the time). It had everything; item puzzles, skills, running around collecting things, and the toughest NPC the game’s ever seen by far; Elvarg. A creature that you needed an item to kill, or it would annihilate you. Technically, the second-ever slayer monster alongside Delrith the Demon, whom you needed to use Silverlight to fight. … that you could only kill once. And your reward was the ability to buy the runite platebody; the most expensive item in the game. If you went around and saw someone in full runite armor, they had respect. The same kind of respect as seeing someone in full blood-dyed sirenic.
Even still, compared to today, it was still a very generic fetch-and-kill quest, but it was still tricky. A lot of the danger of the quest relied on players being a generically low level and forcing them to go through some higher leveled enemies, which worked because players had to take 3 hits every time an NPC touched them, and running wasn’t a thing. Moving around was strategic. Nowadays, you can double-surge/bladed dive through NPCs like they’re not there.
From there came the members quests, and those were a lot of the same formula. With a much bigger and more diverse game world, law runes and teleportation became a more tangible method of getting around, and so the quests started to become themed to location, like the Watchtower Quest, Temple of Ikov, and Tourist Trap. The stories could be developed more because the place itself could aid the storytelling. The Underground Pass quest especially so, as it was an entire super-dangerous dungeon that players often died in without getting in a single fight.
That, and around this time NPC chatter became instanced, so everybody could talk to the same NPC at once. This allowed many of the duplicate NPCs to be removed, cleaning the place up a bit. There were still a lot of duplicate NPCs around for the sake of fighting if needed, but that couldn’t be helped.
They remained simple. Sometimes there would be a slightly new mechanic, but a lot of the assets were reused and recolored, and many of the puzzles were relatively simple memory, order, and item matching puzzles. Nothing complicated like Sudoku or Puzzle Boxes. But there was an advantage to this simplicity. It allowed them to create new quests with relative ease. Sometimes they would release multiple new quests in a single week! We were at nearly three a month for a good while.
The final quest in Runescape Classic was the Legends Quest, which again combined all the things the development team had done prior. New environment, new landscape, new enemies and bosses, item-based puzzles, and skill levels beyond what most players could even dream of attaining. Herblore especially; level 45 herblore doesn’t sound hard, but back then Chaos Druids were about the only way tangible to get herbs and ingredients at all. No Grand Exchange, no Farming, no compromise. Oh, and the boss? You had to fight them in a single go with drained prayer and no food, because you couldn’t eat or drink in combat, and if you ran, he vanished and you had to start over. Three times. Fight to the death, baby!
And then came Runescape 2, and the whole formula changed. The Legends Quest suddenly became much easier with the ability to eat and drink potion during fights, and the whole formula changed. Areas weren’t as dangerous anymore because players could just run through the mobs, who couldn’t run themselves, runecrafting introduced much more readily available runes, and we saw a proper combat triangle appear rather than ranged and magic being supplementary to the main combat ability of melee.
So from there, we saw quests appear with a slightly different format. Namely, quests and battles with the environment playing a factor like Death Plateau, Nature Spirit, and Monkey Madness. Monkey Madness was especially difficult because of how merciless it was towards players; it was immensely easy to die, and we were forced into playing the game strategically like we used to do in Runescape Classic; avoiding detection, plotting out paths, and pacing ourselves with food, prayer, and healing. The age-old formula had all but returned.
As the Runescape world continued to advance, homage was paid to the massive scale by a tiny little quest called One Small Favour, which showed the player-base just how immense and epic a quest could really get, and that the folks at Jagex were not at all above pitting us with a quest that spanned the entire Runescape world, having us interact with so many familiar and possibly pivotal NPCs all over. This was the start of the great epics we would see in the form of While Guthix Sleeps, The World Wakes, and the World Events.
At this point, quests were no longer just fetch-and-kill. They weren’t just about satisfying somewhat ungrateful or overly grateful NPCs. They were now changing the Runescape world itself. We advanced an age, we killed a King (regicide) and a Queen (slug), we grew the city of Prifddinas, we pried open the doors to Menaphos, and we saw the return of the Runescape Gods, whom until then were these omnipotent observers that were merely the subject of lore and player-asked God letters (check out letter 21; you might find a familiar face!). And these crazy events spawned a whole new series of quests and stories. They were not simply continuing with sequels; they were spawning a whole new series.
However, for a while, many of the quests spanned familiar areas, doing little more than create new characters and shove us into smaller dungeons now and then for the purpose of creating elaborate puzzles. This was because it was getting difficult to create new assets and many of the designers were already hard at work remaking existing areas. Falador alone saw at least two complete reworks, to name an example.
But then, something happened. They released the NXT engine. And this was the start of an absolute graphics explosion. The world became immersive with skyboxes and a much greater draw distance. Visual flexibility thanks to a dynamic camera and even free-roaming made the level of explorability so much more incredible that even a relatively simple fetch-and-kill quest like Death of Chivalry was an absolute visual masterpiece of a quest.
Since then, quests became scarce. Perhaps 4 new quests a year. So much work and effort were put into their design, story, and audio that they no longer had the same level and complexity as a quest like Sheep Shearer. In fact, some quests took so long to develop that they built up hype with some 2-week-prior preparation events to build up hype and remind players what was going on in the storyline because it had been so gosh darn long.
That’s where we stand. Will it improve? Will we need a larger frequency of quests in the future? Honestly, I don’t think we will because the formula for quests and the evolution of Runescape assets have made the standards for quests so high that they can no longer bring us quests with the same appeal as we used to have. There are still “miniquests” and “events” that give us something to do, and a whole bunch of post-quest content that takes a considerable amount of grinding to help us pass the time. But, with the economy seeing billions of coins as the high-level norm, skills like surge and home teleports to make getting around trivial, and an enormous number of options for combat, we’re not going to get the same level of excitement in a cut-and-paste quest and we’re gonna have to just live with it.
Such is the folly of progress. Of evolution. We get better. And we get slower. Fortunately, as we get slower, we also get more patient. And when the quests do eventually come out, they push boundaries once more and become absolute treats for us loyal, long-term Runescape players.
So I hope you guys have a happy 2021. I hope that the folks at Jagex will allow themselves to return to the cut-and-paste formula to help diversify the Runescape world with simple quests to kind of ease off our expectations and, in a word, de-evolve a little. Then perhaps we could see the return of weekly, or even bimonthly quests. Even if they are fetch-and-kill.
But that’s always worked in the past. Because quests are fun! Because they’re quests!
Cheers, cannoneers!
Alex’s Analysis – Keeping Up With Tradition
posted by Alex 43 on 20th December 2020, at 3:42am | Discuss Article
To my surprise and delight, the Christmas event of the year reused the beautifully developed content from the past year that was both epic and familiar, and with some extra awesome features, character design, and animations, a sequel was created. One that brought us back to the Land of Snow and reuniting us with our […]
Alex’s Analysis – Eff This Distraction
posted by Alex 43 on 18th September 2020, at 1:56am | Discuss Article
Hah! You fell for the click-bait title! I actually really like this new Distraction and Diversion! And now that I said that, you are wondering “what the heck is wrong with this guy?”, and hence are hooked on my article! Pro-writer moves! #NoBig. OK. For real, though. New Distraction and Diversion. It gives you a […]
Alex’s Analysis – Starting Fresh
posted by Alex 43 on 24th January 2020, at 12:56am | Discuss Article
Happy new year, and happy new decade, and enjoy perhaps the only year in your life that will have the first two and last two numbers match, and enjoy the countless 2020 vision jokes. It’s 2020, and it’s the start of new beginnings, and we’re all going to have a wonderful time in Runescape, as […]
Alex’s Analysis – 2019 Summary
Image Credit: Carnivore Style Alright. I’ve just eaten a fancy garlic-buttered steak and downed a glass of Cabernet Sauvignon and I am ready. Ready to sit back and look back on the year 2019. Look at all the good things, the bad things, and… nah, just kidding, I’m here to look back at all the […]
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The Huntingtonian
Huntington University's Student Newspaper Since 1918
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Meet Your Student Government’s New Executive Board
The 2020-2021 academic school year might be a little unusual due to several current events. Get to know the four students on SGA who you can bring your concerns to. By Michael Lehman, Editor-in-Chief
by Michael Lehman
The 2020-2021 academic school year might be a little unusual due to several current events. Get to know the four students on SGA who you can bring your concerns to.
By Michael Lehman, Editor-in-Chief
Almost two months have passed since life was normal on HU’s campus. In mid-March, most students left Huntington for a spring break that never truly ended thanks to the ongoing coronavirus pandemic.
But during those last few weeks on campus, four HU students managed to get the 75 student signatures they needed to run for the Student Government Association’s 2020-2021 executive board (EB).
Junior Ashley Spirek will be the new student body president. She will work alongside senior Josh Wilson (vice president), freshman Corbin Hancock (secretary) and sophomore Seth Parsell (treasurer), who is returning for a second year in his position.
What makes this EB particularly unique is that it will be made up of students from each of the four current grade levels. Additionally, they are all from different academic disciplines.
“The new EB is going to bring a very different kind of energy and leadership into Huntington University next year!” current president SangJin Woo said in an email interview. “I am excited to see how Ashley and her team are going to impact the campus next year!”
Woo, who is graduating this month, will retire from EB alongside junior Hannah Schonfeld (vice president) and sophomore Erika James (secretary). Woo appeared to have a lot of faith in the new EB’s potential.
“They are all hardworking, dedicated, and intelligent people who will create a greater synergy when they work together,” he said. “I wish them the best of luck, and I will keep them in my prayers!
Get to know each of the four students by exploring and skimming their profiles below.
TOMORROW’S LEADERS: Meadows Hall representative Ashley Spirek will step up as student body president next year. Miller Hall representative Josh Wilson will serve alongside her as vice president. (Photo provided by the Student Government Association)
PRESIDENT: Karyn “Ashley” Spirek
MAJORS: history, philosophy, political science, international development studies
MINORS: non-Western studies, refugee studies
TIME ON SGA: 1 year (Meadows Hall rep)
MESSAGE TO HU STUDENTS:
“[SGA is] the communicative bridge between the student body and the administrative body, and we’re here to make sure that student voices are being heard.
“I chose this role because I care a lot about Huntington University students. … Furthermore, I think there is a huge window of opportunity for SGA to participate in a pivotal moment of growth that our HU community will be going through next year. It will be hard year, and it is a year that is marked by tremendous change. I think it might be possible that I could bring a certain perspective would be helpful to SGA next year as we learn to listen to a community who is going through change and instability.
“I grew up in Kyiv, Ukraine, and my city went through a peaceful (turned violent) revolution in 2014 called the Euromaidan Revolution, or the Revolution of Dignity. The revolution, coupled with Russia’s annexation of Crimea, Ukraine’s southern peninsula, and the war in the Donbass region of Ukraine, forced my family to consider evacuating our home. We packed our bags and had no idea what would happen next.
“In my life, that was the epitome of change and uncertainty. Though the changes we are going through now are different from my own life example, we are facing the difficulties of change right now that are taking place as a result of the current global pandemic, as well as the changes that are taking place at HU. As the HU community, we are facing uncertainty and instability, and, for that reason, we have an incredible window of opportunity to find creative ways to build community and, thus, a sense of stability in the midst of instability.
“I hope that I can contribute this perspective as we move forward as a Student Government Association, and I am excited for the opportunity to think creatively and intentionally about what is best for our student body.”
VICE PRESIDENT: Josh Wilson
MAJOR: biology
TIME ON SGA: 2 years (Miller Hall rep)
“I have enjoyed my two years serving as the representative for Miller Hall and would like to now take the next step into leadership by becoming a member of the executive board. I also hope to serve again as Resident Assistant next year. As I will be a fifth-year senior next year, I feel like a have a good idea [of] what goes into the role [and] have a good understanding of the campus concerns and what ways I can serve students. Because, that’s what this position, and SGA as a whole, is all about. I loved my time at HU and want to make it a better place for all students.”
TREASURER: Seth Parsell
THE SOLE VETERAN: Seth Parsell is one of few students in recent years to serve on two back-to-back EBs. He is from Powell, Ohio. (Photo by Sarah Fiechter)
MAJORS: finance/economics, management
MINORS: accounting, entrepreneurial small business management
TIMES ON SGA: 2 years (current treasurer; former freshman rep)
“Currently, I am the treasurer of SGA and would like to continue my position as treasurer for the next academic year. SGA has allowed my leadership skills to grow as well as my love for Huntington. I want to represent the students of HU and make a difference on campus. With my various business-related majors and minors, I am very capable of handling the treasurer position as I have done so for the past school year.
“As treasurer, I want to make sure SGA uses its budget wisely and for the whole student body to benefit. I look forward to next year, and I am ready to tackle any challenges that come my way.”
SECRETARY: Corbin Hancock
THE NEW SECRETARY: Corbin Hancock, the youngest of the group, grew up as a missionary kid in Mexico. (Photo from SGA Facebook page)
YEAR: freshman
MAJOR: youth ministry
TIME ON SGA: 1 year (freshman rep)
“To future students who I will be serving, I would like to communicate how important it is to know your opinions over things. Your student government is here to make your campus experience better in many ways. We would love your input on how you believe we can improve the campus. I’m hoping to find ways to gauge the student body to more accurately provide for their wants.”
Tagschanges • coronavirus • COVID-19 • executive board • HUB construction • SGA • Student Body President • student government association • Student Life • student spotlight
0 comments on “Meet Your Student Government’s New Executive Board”
HU students: Do you have something you’d like us to publish? A feature story? Opinion piece? Spiritual testimony? Recipe? Comic?
We pay our student writers and artists $20 per article/comic. Students can join at any point in the school year. Email our editors-in-chief to learn more.
General: huntingtoniandesign@gmail.com
Co-Editors-in-Chief:
Laura Caicedo: caicedol@huntington.edu
Peyton Pitman: pitmanp@huntington.edu
Melissa Farthing, Copy Editor
Onalivia Smith, Designer
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A Blast from the Past (8/25/13)
shotgunsusie
Last year one of my readers named F8 provided a link to a dinar site called RolClub where a pumper named shotgunsusie was saying the RV was done and the rate would go live by Oct. 1, 2006. A subsequent post mentioned a target of $1.68 for the revalue. Another member named rentonrolr provided a link to the financials at the CBI website and said that $1.68 was impossible given the (at that time) money supply of 10 trillion dinar in circulation with an M2 of 17 trillion. He was banned shortly thereafter. It’s amazing to read this from seven years ago and see how little has changed. Sure, the numbers are different. The money supply has grown, there are hundreds of gurus now, dozens of dinar forums, and the dinar has gone up in value about 20% (due to the crawling peg policy from Nov. 2006 – Jan. 2009 that allowed them to get inflation under control) rather than the 250,000% increase Susie was pumping. But the basic argument of whether Iraq can RV to an amount that would provide a windfall to dinar investors hasn’t changed, and of course people who point out inconvenient facts are still called names and banned from dinar forums. Reading through this thread was a real eye-opener.
http://www.rolclub.com/rumors-prediction/10780-r-v-before-october-1st-with-clock-set.html
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Fantasy, science fiction, and contemporary short stories, often with biblical themes
The God-Talk Club and the She-Bears
[This is a work of fiction, from my God-Talk Club series. – added 11:42 central time]
Small talk was dying down and everyone had their drinks. Mark had a question:
“I’ve been given an assignment,”1 he said to the group, and I’d like your thoughts.
“What is it?” asked Mandy.
“We’re supposed to write a 10 minute homily on 2 Kings 3:23-24.”
“Ten minutes? That’s going to cramp your style. You can’t tell them everything you’ve learned in your seminary classes.” Mandy was laughing as she said it, and Mark took it in good humor. He really did like to put his whole seminary training into each homily.
“Ten minutes,” echoed Jerry. “You can’t really get to the meat of a scripture in that period of time.
“I didn’t know you Presbyterians had long sermons. I thought you generally had about 20 minute homilies,” said Mandy.
“Not at my church. It’s more like 30-40 minutes, and sometimes we get more in the pastor’s Sunday School class.”
“Oh, you learn something new every day,” said Mandy. “But we should get back to Mark. What are your questions?”
“Well,” said Mark and paused. He felt like he knew what he’d hear from each person and was almost afraid to start. “It’s such a violent story. Elisha seems to get offended and so he slaughters a bunch of kids. Where’s the moral in that?”
Justine, Mandy, and Jerry started talking at once, then started to apologize to each other.
Over the confusion, Bob Norman cut in. “OK, I’ll bite. What is this story of the she-bears?”
“You don’t know that one?” exclaimed Mac. “That’s a skeptical staple. A Christian says ‘God is love’ and you say ‘But what about the she bears?’ I’m going to have to revoke your skeptic’s license.”
Bob was working on getting used to Mac. He was a science teacher, an atheist, and quite convinced, but he had been raised in a conventionally religious home, one where he didn’t see church all that often. Until he had gotten together with the God-Talk Club he hadn’t argued religion that much. He just didn’t believe.
Mac, on the other hand, seemed to think that the purpose of skeptics was to argue with Christians. She knew more about Christianity than most Christians.
“So what is the story?” asked Bob, looking at Mac.
“Well, this prophet named Elisha was walking along, and some children started taunting him about being bald. So he cursed them and called some she bears to maul them. The bears got 42 of them.”
Jerry cut in, “Well, not precisely. How about we read the text as it’s written?”
Jerry pulled out his Bible and read:
(23) He went from there to Bethel, and while he was going up on the way, some small boys came out of the city and jeered at him, saying, “Go up, you baldhead! Go up, you baldhead!” (24) And he turned around, and when he saw them, he cursed them in the name of the LORD. And two she-bears came out of the woods and tore forty-two of the boys. — 2 Kings 2:23-24 (ESV)
“OK,” asked Bob, “so why are they telling this guy to go up? And is this Elisha you’re talking about?”
“Well Elijah had just been taken up into heaven, so the boys were suggesting that Elisha do the same thing,” said Jerry.
“But I don’t believe that anyone can go up to heaven,” said Bob.
“Why don’t we discuss the story based on what the people who wrote it believed?” asked Mandy. She barely cut off Jerry who had been about to argue the point. He again thought about how hard it was for him to take Mandy seriously because of the way she behaved, yet she had these flashes of wisdom.
“Maybe the boys didn’t believe that Elijah had ascended either,” said Mark. “They might have been suggesting that Elisha was lying. Elisha was the only witness, after all.”
“That’s quite possible,” said Mandy.
“But it doesn’t help us much in understanding the story,” said Jerry. Whatever their reasons they were taunting God’s prophet.”
“So Justine,” said Bob, turning to look her right in the eye. “What would you do if some children in your congregation were taunting you?”
“Well, it would depend on what they were doing,” she answered. “If they’re just joking, I’d laugh and go on. If they’re threatening me, I’m going to deal with it. Worst case, I might call the police. I’ve had some teenagers who needed police intervention. I don’t like it, but it happens.”
“But you wouldn’t curse them, or, in the absence of readily available she-bears, you wouldn’t release the dogs on them,” said Mac decisively, as though she thought she had just won a point.
“Precisely,” said Bob.
“But Justine isn’t a prophet,” said Jerry.
“So? She’s a pastor. Isn’t that close enough?” asked Bob.
“I hardly think so. Elisha was the greatest prophet of his time. It would be more like taunting the president,” said Jerry.
“But the secret service doesn’t shoot adults who taunt the president, much less children,” said Bob.
“Supposing a teenager–and these boys could be teenagers–was carrying a handgun and waved it at the president. Then what would happen?” asked Jerry.
“It’s quite possible that the secret service might shoot the teenager. But there’s no indication these children were carrying guns, or swords or spears,” said Bob again.
“But there’s nothing that says they didn’t either. They might have been very threatening.” Now Jerry looked like he was making a point.
“But wouldn’t that be adding something to the text?” asked Mark.
“Well, we’re adding to the text whether we assume they’re little children or teenagers, and whether we assume they had no weapons or lots of them. It doesn’t give us those details,” said Jerry.
“So shouldn’t we deal with the text as it is?” asked Justine. “It seems to say that taunting the prophet was enough provocation, and that God responded to Elijah’s curse by sending the she-bears. I don’t particularly like it, but that’s what it says.”
“Well, actually, I don’t think so,” said Mandy. Everyone started looking right at her. “The text doesn’t tell us whether Elisha’s action was justified. It just tell us that it happened.”
“So is it possible that Elisha might not be doing the right thing here?” asked Mark.
“I think so. I think Elisha was tired and angry and so he cursed the children.” Mandy had that “mother concludes and has made the point to the children” look she got from time to time. The fact that she was sprawled carelessly sideways across an easy chair detracted from the effect.
“So why would God honor his angry request?” asked Jerry.
Mandy considered for a moment. “Because he was God’s prophet. What would happen if he cursed someone and nothing happened? God has to go hunting for a new prophet!”
“I really don’t think that’s an appropriate way to speak about a prophet. Surely a prophet wouldn’t do wrong in a situation like this,” said Jerry.
“Elijah made mistakes. Moses made mistakes. David was a man after God’s own heart and he committed adultery and then murdered someone to cover it up. What makes you think Bible characters always do right?” said Mandy.
“But in all those cases we have a clear indication that what they did was wrong. Not here,” replied Jerry.
“Well, from my point of view that makes God look even worse. He will kill forty-two children in order to keep his prophet respectable,” said Bob. Mac nodded.
“But God can do anything he wants! We don’t have the right to judge God’s actions,” said Jerry.
“So when you say, ‘God is love’ is that your considered judgment, or are you just repeating what God told you to say?” asked Mac.
“I know that God is love,” said Jerry.
“But how do you know? Can you know that God is love without looking at God’s actions and deciding, ‘Those are loving actions?'” asked Mac.
“I think she’s got a point,” said Mandy. “After all, we testify to God’s love and to the things God has done for us. Have we not looked at God’s action and said, ‘That is love’?”
“But we wouldn’t even know what love was if God didn’t tell us!” said Jerry.
“Well, I agree with Jerry,” said Justine. “God has the right to do what he wants. So I think there must be something there that those children or teenagers did to deserve what happened to them. If God did it, it must be right, and it says right there [she pointed to Jerry’s Bible] that God did it!”
“I’ve got to agree with Jerry as well. It seems that you [he looked at Mandy] and Mark want to have the story in your Bible but you don’t want to accept what it really says.” Bob looked at Jerry. “Not that I agree with you about anything else!”
“I would never even think it,” said Jerry dryly.
“I have to disagree. You’ve both decided what the story must mean. There are many other statements about morality in the Bible. I think that if we are told elsewhere that an action is wrong, we are not forced to conclude that a person who does that in a story is right. That was complicated,” said Mandy, and grinned.
“But then you are saying that God did something wrong,” said Jerry, and Bob and Mac both nodded.
“I’m saying that God worked with people as they were. You can’t always have ideal actions when you’re not dealing with ideal people.”
“There I agree with you, Mandy,” said Justine. “I don’t really have a problem with this story, but God does work with us where we are.”
“I think I like Mandy’s explanation,” said Mark. I wonder if I can say it in 10 minutes? I’m inclined to give all the explanations and let people choose.”
And with that, the group began to break up.
1The real-world source of this question is not a professor at my imaginary seminary but David Ker at his Lingamish blog. I already responded in a real-world sense on my Participatory Bible Study blog.
Posted in Bible Related Short Stories, Contemporary Short Stories, God-Talk ClubTagged fiction, religion
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Norwegian Templar Knight claim he called the police during the massacre
Templar Knight Anders Behring Breivik claim he called the police during the massacre on Utøya. The Norwegian conservative daily Aftenposten reports that the Templar Knight Anders Behring Breivik informed the police that He was doing the massacre on Utøya in Norway. Breivik claimed he called the police and called him self a brigader. He also… Read More Norwegian Templar Knight claim he called the police during the massacre
August 2, 2011 August 2, 2011 ivarfjeld2 Comments
Norway: Mayor honored football fans using skulls and songs full of filth and hate
Just after mayor of Oslo had honored the sports club Vålerenga for their work for multiculturism, their fan club sung perverted songs full of hate and filth. Last week my son took me to a football match in Oslo. I have not been on such a sports arena for more than 10 years. It was… Read More Norway: Mayor honored football fans using skulls and songs full of filth and hate
Netanyahu trust Obama will use the US veto against “Palestine”
“We are working to ensure a US veto in the UN Security Council, but that will not prevent a majority in the General Assembly.” This is the hope expressed by Israeli Prime Minister Benjamin Netanyahu Netanyahu said “we are interacting with the US to put together a document [for an agreement with the Palestinians] using… Read More Netanyahu trust Obama will use the US veto against “Palestine”
August 2, 2011 August 1, 2011 ivarfjeld23 Comments
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CultureTop Section
Capeshit’s Endgame
Maggie Siebert
Susan Blase / Flickr
If there is a culture war, nerds won it seven years ago. Since 2012 saw the release of the first Avengers film, self-described geeks have, through reckless spending and uncritical word-of-mouth support, made video games and comic-book movies the dominant cultural forces around the globe. A few short years was all it took to see tweens dreaming of professional streaming careers and a big budget Aquaman film becoming a highly anticipated release.
These massive spectacles rake in billions of dollars and as many adoring fans, forcing any enterprise that can’t match that level of financial gain so far into the periphery it’s a wonder other properties get made at all. Preferring something else, something without pastel-shaded heroes and villains, is not just unthinkable to fans, but increasingly untenable in reality. Even a substantial degree of political discourse is centered around dissecting the social responsibility movies, TV series and games have. More than ever before, audiences view their world through the lens of the content they consume.
What’s more, the distinctions between all of these titles are rapidly blurring. A third of the way through Endgame, the latest and final installment of the Avengers quadrilogy, Bruce Banner and obnoxious anthropomorphic raccoon “Rocket” visit Thor in New Asgard. The once-buff Thor, in a depressive rut following Thanos’ wide scale genocide of half the life on Earth, now sports a hefty beer gut. As Banner and Rocket attempt to persuade him into returning to the team, one of Thor’s roommates plays Fortnite. The action is interrupted for a solid half-minute when Thor hops on voice chat and chews out a rude player, excoriating him as a basement dweller and threatening to shove his arms up his “butt.”
It’s tempting to think of this as self-aware; comic book fans have long been associated with loserdom, and a marginally smarter movie might have the audacity to poke fun at its own audience. But like most moments in Endgame that don’t involve punching, this scene merely asks that the audience laugh in recognition. We know what Fortnite is, and we know what a loser gamer who lives with his mother looks like. It’s funny to see these things on the big screen, just like it’s funny when the Hulk “dabs,” or when Tony Stark quips that Rocket looks like a Build-a-Bear.
It fails at even the most basic of filmmaking conventions. Its sole goal is to force as many characters from within the franchise into its excruciatingly long runtime. Endgame is, quite transparently, a 181 minute cross-brand advertisement. Characters make quips about Axe Body Spray. Everyone seems to be driving an Audi. A dramatic moment involves a ringing Google Pixel, which the camera lingers on for what feels like an eternity. This is excluding the $200 million worth of promotional tie-ins with Ulta, Ziploc, McDonald’s and countless others.
More than that, it is a $400-million advertisement for the Marvel Cinematic Universe itself. Every character fans could dream of gets screen time, and Endgame’s status as the second highest-grossing film of all time a mere week after its premiere all but ensures each of these heroes will return to the big screen within the next decade. Likely much sooner, given that nine new movies in the Marvel Cinematic Universe are slated for release by July 2022. The Marvel Cinematic Universe is the apex of American culture; it is our biggest moneymaker, it dominates water cooler talk. It can be discussed with any person of any age.
Marvel fans do not seem bothered by any of this. What does bother them is any critique of their beloved franchise. The very idea that someone might not enjoy the MCU may as well be an admission of alt-right allegiance, (or, in capeshit parlance, loyalty to Hydra). Never mind that billions of dollars have been spent on both the production and simple act of viewing these spectacles. Never mind that the success of these films relies on dodgy alliances with predatory firms like Quicken Loans, as long as more adventures are churned out each year.
There is a comic strip often used as a reaction image when someone complains about a beloved media property. It shows one man pinching another’s lips shut. “Shhh,” he says. “Let people enjoy things.”
What this sentiment really communicates is “let me enjoy what I like without having to answer for it.” On the rare occasions they critique the series, Marvel fans, (or anyone who identifies as part of a “fandom”) are seemingly only capable of having vacuous conversations about representation; how we needs to “do better” by casting more women and making more characters gay. But when it comes to interrogating the implications of having, say, a billionaire playboy arms dealer be the character that pulls back the world from the brink of doom, their lips are sealed. These are films that violently reinforce the status quo, where dissent is always squashed in favor of liberal hegemony. What is last year’s Black Panther if not the story of a global revolution triumphantly squashed by nationalists?
These films do not merely cape for liberalism, though; they enforce it. The sheer number of ventures involved in raising funds for, producing, filming, marketing and releasing these films demands compliance from nearly every industry. A staggering amount of resources, financial and otherwise, are diverted annually to ensure the success of these ventures. Google, Quicken Loans and Ant-Man may all seem like disparate entities, but their connections to and reliances on each other run quite deep.
Frankfurt School grouch Theodor Adorno made essentially the same point in Dialectic of Enlightenment, in which he famously attacks the ascendant “culture industry”:
“The people at the top are no longer so interested in concealing monopoly: as its violence becomes more open, so its power grows. Movies and radio need no longer pretend to be art. The truth that they are just business is made into an ideology in order to justify the rubbish they deliberately produce. They call themselves industries; and when their directors’ incomes are published, any doubt about the social utility of the finished products is removed.”
This was first published in 1944, when the dominant film studios were Warner Brothers and MGM. (Now, of course, things have changed significantly: the two big players are Warner Brothers and Disney.) All that’s changed are the franchises, and even those have little in the way of meaningful difference. As Adorno said, “The varying budgets in the culture industry do not bear the slightest relation to factual values, to the meaning of the products themselves.”
What does it mean to “let people enjoy things” when those things are not just emblematic, but a primary cause of moral and aesthetic rot? What are the ramifications of letting someone enjoy franchises that not only function as blockbuster advertisements, but shape worldviews? Why is it acceptable for adults to develop full-scale obsessions with these titles?
Superhero movies are blatantly transparent power fantasies, just like the comic books they’re based on. Appeals to diversity happen not to rectify unbalanced power structures, but to let more people feel like they, too, could be Spider-Man. But as much as we may be tempted to believe the average Marvel fan is like the basement living Fortnite player from Endgame, the truth is that these are movies for the average person. And in an era as hopeless as this one, where collapse may very well begin at any moment, the average person wants to feel powerful, even if that means infantilizing oneself.
For all the surface-level wokeness the Marvel Cinematic Universe inspires, at heart it thrives on a sort of blase centrism. Both the right and left make allowances for what values art and entertainment ought to instill in viewers. But when it comes to superhero movies, all that matters is the individual’s response. Left critiques of the franchise’s corporatism and right critiques of its identitarianism are no match for what is ultimately the dominant force in contemporary entertainment: pure, libidinal enjoyment.
Bombastic effects and painfully long fight sequences coupled with jokes anyone of any age can understand; this is the formula studios have spent decades refining. Any modicum of intelligence possessed by the best of the comics, (and there is very, very little) is completely drained in favor of material designed to appeal to literally everyone. These movies take no risks. They are thoroughly vetted, focus-grouped, market-tested. That one could walk away from three hours of such blatant pandering feeling anything other than insulted is indictment enough of our cultural moment.
None of this is to say the films of the past were somehow better, before the advent of nine-figure budgets and movie stars signed to thousand-picture deals. Nearly all of our cultural output is guilty by association. But resistance to its most ruthlessly cynical urges does seem to be at an all-time low. These films have nothing to say but plenty to hawk, and we’re perfectly content to funnel all of our disposable income directly into Disney’s pockets.
No one should be “allowed” to enjoy something that thinks so little of its audience. The Marvel Cinematic Universe is not disgusting because it’s the first to do this, but because it’s one of the first to do it without pushback. Even film critics can’t be pissed to do their job and thoughtfully pick it apart, evidenced by Endgame’s near universal acclaim. Ultimately, it’s because these movies speak to one commonly held desire: to be coddled in the face of oblivion.
Maggie Siebert is a writer based in Providence, RI. Follow Maggie on Twitter at @magdacsiebert.
TagsCapeshitMarvelSuperhero Movies
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Wedding Singer
Funeral Singer
madsen.ingrid@gmail.com
About Ingrid Madsen – Wedding Singer
Ingrid Madsen is an internationally renowned professional singer and church wedding singer in Ireland.
Ingrid has performed at countless events both at home and abroad with bands and choirs including a sold out 10 week tour of America with the Dublin Philharmonic Orchestra, as part of the “Women of Ireland” group. She has also been performing with The Controversial Allstars at events and weddings since 2003.
No stranger to the stars, Ingrid was spotted by Brian Ormond and Pippa O’Connor and was asked to perform at their wedding ceremony in Enniskerry. Brian told VIP magazine “Everyone was taking about Ingrid Madsen and Dave Browne, who sang at the church and restaurant which added a lovely element. People say you don’t notice what happens in the church but between the great singing and wonderful priest it made it so special for us!”
Voted top Irish Wedding Singers in Ireland by Weddingsonline.ie. Ingrid Says “I am extremely honoured and proud to have been shortlisted into the top Irish Wedding singers in Ireland considering the amount of other extremely talented wedding singers there were in my category!”
Specialising in church music, Ingrid can create the perfect wedding music for your wedding ceremony, whether you choose a church wedding ceremony or a civil ceremony. Ingrid’s voice has been described as pure, powerful and passionate, which can captivate any audience. She has a unique natural voice and always endeavours to create the perfect atmosphere to suit the mood of any song being sung.
Ingrid is also a professional recording artist also known as Ping and recently released her debut single which you might have heard on Irish radio. Something Worth Saving was playlisted on RTE radio1 and available to download on iTunes. Click to buy Something Worth Saving iTunes.
Check out the songs page for more samples of Ingrid’s voice and to book Ingrid for your church music, click on the contact page.
Copyright © 2019 Ingrid Madsen. All rights reserved.
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← JAZZ MANGLISH, AGRICULTURAL STYLE
TOO MARVELOUS FOR WORDS! →
REMEMBERING JOE THOMAS
Posted on June 11, 2009 | 33 Comments
The trumpeter Joseph Eli Thomas — fabled but truly little-known — is almost always confused with his higher-profile namesake, who played tenor sax and sang in the Jimmie Lunceford Orchestra.
But a quick scan of the people our Joe Thomas played with should suggest that his colleagues thought very highly of him. How about Fats Waller, James P. Johnson, Art Tatum, Teddy Wilson, Johnny Guarneri, Earl Hines, Fletcher Henderson, Sidney Catlett, Coleman Hawkins, Jack Teagarden, Bud Freeman, Ed Hall, Vic Dickenson, Red Norvo, Roy Eldridge, Emmett Berry, Cozy Cole, Lil Hardin Armstrong, Claude Hopkins, Buddy Tate, Pee Wee Russell, Tony Scott, Buck Clayton, Woody Herman, Trummy Young, Rudy Powell, Eddie Condon, Benny Carter, Jo Jones, Benny Morton, Al Hall . . . . ? Clearly a man well-respected. But he is an obscure figure today.
He can be seen as a member of Art Kane’s famous 1958 Harlem street assemblage. Shirtsleeved and hatless, he stands with Maxine Sullivan and Jimmy Rushing to one side, with Stuff Smith on the other. Fast company, although the sun must have been bothering him, for he looks worried.
In another world, Thomas would have had little reason to worry, but he came up in jazz when hot trumpeters seemed to spring out from every bush. To his left, Red Allen and Rex Stewart; to the right, Bill Coleman, Emmett Berry, Bobby Hackett. Rounding the corner, Buck Clayton, Cootie Williams, Benny Carter, Frank Newton. So the competition was fierce. And Thomas often had the bad fortune to be overshadowed: in Fletcher Henderson’s 1936 CHRISTOPHER COLUMBUS band — the one that recorded extensively for Victor and Vocalion — his section-mate was a fireball named Eldridge. In Fats Waller’s big band, Thomas played section trumpet and the prize solos in Fats’ Rhythm went to Herman Autrey or Bugs Hamilton. And then there was a colossus named Armstrong, apparently blocking out the sun. John Hammond was busy championing other players, all worthy, and never got around to pushing Joe Thomas into the limelight. Although he recorded prolifically as a sideman, he never had a record date under his own name after 1946.
But Thomas got himself heard now and again: his solos shine on Decca recordings (alongside Chu Berry) under Lil Armstrong’s name, and on a famous Big Joe Turner date for the same label that featured Art Tatum and Ed Hall. On the much more obscure Black and White label, he recorded alongside Tatum and Barney Bigard; for Jamboree, he was captured side-by-side with Don Byas, Dave Tough, and Ted Nash.
Later in his career, the British jazz scholar Albert McCarthy featured him on a Vic Dickenson session (Vic, like Tatum, seems to have admired Joe’s quiet majesty), and he popped up on sessions in the Fifties and Sixties in the best company. Whitney Balliett celebrated him in an essay, and the drummer Mike Burgevin used him on gigs whenever he could.
Thomas’s most important champion has to have been the Javanese jazz enthusiast and record producer Harry Lim, whose biography should be written — producing jam sessions and heading one of the finest record labels ever — Keynote — then shepherding another label, Famous Door, through perhaps a dozen issues in the Seventies. I gather that his day job was as head of the jazz record section in the Manhattan Sam Goody store: probably I saw him, but was too young and uninformed to make the connection.
Lim loved Thomas’s playing and featured him extensively on sessions between 1944 and 1946. Regrettably those sessions were reissued in haphazard fashion in the Fifties, Sixties, and Seventies — vinyl anthologies on the Emarcy and Trip labels — then in a wonderful box set first appearing in Japan, then briefly in the US, then disappearing for good. A number of compilations drawn from that set — featuring Hawkins, Eldridge, Norvo, and Young — made it to CD but seem to have gone out of circulation. And wise collectors aren’t putting them up on eBay. Thomas also appears on a few sessions for the HRS (Hot Record Society) label, and those sessions have been collected in a Mosaic box set, which I believe is still available — although the Keynotes show him off far better.
What made Thomas so special? His tone was luminous but dark, rich — not shallow and glossy or brassy. His notes sang; he placed his notes a shade behind the beat, giving the impression of having all the time in the world at a fast tempo. Like Jack Teagarden, he wasn’t an improviser who started afresh with every new solo. Thomas had his favorite patterns and gestures, but he didn’t repeat himself. Listening to him when he was on-form was beautifully satisfying: he sounded like a man who had edited out all the extraneous notes in his head before beginning to play. His spaces meant something, and a Thomas solo continued to resonate in one’s head for a long time. I can still hear his opening notes of a solo he took on CRAZY RHYTHM on a New York gig in 1974.
What made his style so memorable wasn’t simply his tone — a marvel in itself — or his pacing, steady but never sluggish. It was his dual nature: he loved upward-surging arpeggios that spelled out the chord in a gleaming way, easy but urgent. Occasionally he hit the same note a few times in a delicate, chiming way (much more Beiderbecke than Sweets Edison) — and then, while those notes rang in the air, he would play something at one-quarter volume, which had the shape of a beautiful half-muttered epigram, something enclosed in parentheses, which you had to strain to hear. That balance between declarations and intimacy shaped many a memorable solo.
And when Thomas was simply appearing to play the melody, he worked wonders. I don’t know where a listener would find the Teddy Wilson V-Disc session that produced only two titles (and one alternate take) with a stripped-down version of Wilson’s Cafe Society band in 1943: Thomas, Ed Hall, Wilson, and Sidney Catlett. I mean them no disrespect, but Benny Morton and Johnny Williams may have wanted to go home and get some sleep. The two titles recorded were RUSSIAN LULLABY and HOW HIGH THE MOON — the latter of interest because it is one of the first jazz recordings of that song (including a fairly straight 1940 reading by a Fred Rich studio band with Benny Carter and Roy Eldridge as guest stars!) that I know of. But RUSSIAN LULLABY is extra-special, taken at a slow tempo, enabling Thomas to illuminate the melody from within, as if it were a grieving anthem.
Alas, there are no CD compilations devoted to Thomas; someone eager to hear him on record might chase down the Keynotes in a variety of forms. One session finds him alongside Eldridge and Emmett Berry, and it’s fascinating to see how easily Thomas’s wait-and-see manner makes his colleagues seem a bit too eager, even impetuous. His playing alongside Teagarden and Hawkins on a session led by drummer George Wettling couldn’t be better, especially on HOME and YOU BROUGHT A NEW KIND OF LOVE TO ME.
But he came to prominence, at least as far as the record studio executives were concerned, most often in the years of the first record ban, during World War Two. After that, he emerged now and then in a variety of Mainstream revivals — he played at Central Plaza on an elusive “Dr. Jazz” broadcast; he was a member of an Eddie Condon troupe in the Forties that did a concert in Washington, D.C.
I was lucky enough to hear him a few times in the early Seventies, primarily because of the enthusiastic generosity of Mike Burgevin, a classic jazz drummer whose heroes were Catlett, Tough, and Wettling — someone who also sang now and again, his model (wisely) being early-and-middle period Crosby.
For a time, Mike took care of the jazz at a club named Brew’s — slightly east of the Empire State Building — that had a little room with tables and chairs, a minute bandstand, a decent upright piano. His sessions usually featured himself and the quietly persuasive stride pianist Jimmy Andrews (or Dill Jones), perhaps Al Hall on bass, and a noted horn player. It could be Ruby Braff or Kenny Davern, but often it was Max Kaminsky, Herb Hall, Herman Autrey, or Joe Thomas. (One week, blessedly, Vic Dickenson played three or four nights with a shifting rhythm section: glorious music and a rare opportunity to observe him on his own.)
The sessions were even noted in The New Yorker. I remember noting that these players — people I had heard only on record — seemed to be gigging about ten minutes away from Penn Station. When Joe Thomas’s name came up in print, I was nearly-incredulous. Could this be our Joe Thomas, the trumpeter who was nearly luminescent on his choruses on SHE DIDN’T SAY YES? I think I prevailed on my friend Stu Zimny to come into the city and see whether this was miracle or mirage, and I remember one brilliant set — Joe, Waller-altoist Rudy Powell, Herb Hall, Jimmy Andrews, and Burgevin — that featured Rudy on WHERE OR WHEN and there was a closing CRAZY RHYTHM for the whole band. Of course I had my cassette recorder, but where these tapes are I cannot say. Joe’s chorus, however, is fresh in my mind’s ear.
We struck up a friendship with Mike Burgevin, who was thrilled to find college-age kids who were deeply immersed in the music he loved, and he told us that Joe and he would be leading a quartet for an outdoors concert in a park at the very southern end of Manhattan. I remember that Stu and I brought a heavy reel-to-reel tape recorder, the better to capture Joe’s golden sound, and set it up in the shade, near a tree. This provoked the only conversation I remember having with him. Understandably, perhaps, the sight of young strangers with a big tape recorder made him nervous, and he kept on telling us that we shouldn’t do this, because “the union man” could come by. Perhaps impatiently, we assured him that Local 802 representatuves didn’t seem to be hiding in the bushes, and that we would take the blame if anyone came around. He could pretend that he had no knowledge of our criminalities. It was a less memorable occasion: the quartet was filled out with someone of moderate abilities on a small electric keyboard, the bassist played an over-amplified Fender. Joe fought his way upstream, but it was difficult. In retrospect, I feel guilty: was he worrying about the union man all the time he was playing? I hope not.
He also got a chance to shine twice at the 1972 Newport in New York concerts, once at an affair devoted to Eddie Condon and his music. It was a characteristically uneven evening. The sound engineer at Carnegie Hall amplified the piano so that it sounded other-worldly, and Thomas (perhaps playing the role of a more modest Hot Lips Page) was brought on, along with J.C. Higginbotham, for a closing version of IMPROMPTU ENSEMBLE. Of that occasion, I remember a stunning Bobby Hackett chorus and break, but Thomas didn’t get the space to do what we knew he could. He also was a member of Benny Carter’s SWING MASTERS big band — its rhythm section featuring Teddy Wilson, Bernard Addison, Milt Hinton, and Jo Jones (!) and Thomas took a wonderful solo on a very fast rendition of SLEEP.
I don’t know what kept him out of the limelight after that, whether it was ill health or tiredness? Was it that more showily assertive trumpeters (and there were plenty) got the gigs? Whatever the reasons, he seems to have faded away.
Ironically, Mike Burgevin had issued three vinyl recordings on his own Jezebel label that featured Herman Autrey, Jack Fine, Rudy Powell, and Doc Cheatham . . . which, in a way, led to Cheatham’s rediscovery and second or third period of intense (and well-deserved) fame. Had circumstances been different, perhaps it would have been Joe Thomas playing alongside Nicholas Payton, and that is to take nothing away from Cheatham.
I had begun to write a post about Joe Thomas very shortly after beginning this blog, but shelved it because so little of his work is now available on CD. But the impetus to celebrate him came in the past few days when the Beloved and I had the great good luck to hear Duke Heitger on a brief New York City tour. I have admired Duke’s work for a number of years, and think of him as one of those players who honors the tradition — subtly yet passionately — without imitating anyone. But on a few occasions this last week, Duke would get off a beautiful phrase that hung, shimmering in the air, for a second, and I would think, “Who does that remind me of?” And the answer, when it came, startled me: the last time I had heard something quite so lovely was in listening to Joe Thomas in his prime. Duke is too much his own man to have copied those Keynotes, but it’s an honor (at least in my estimation) to come close to some of Thomas’s quiet majesty.
One other person who thought Joe Thomas was worthy of notice was the esteemed photographer William P. Gottlieb. In this shot, taken at the Greenwich Village club “The Pied Piper,” sometime between 1946 and 1946, Thomas is third from the left, the only African-American. To his left is Harry Lim:
Here he is playing alongside pianist Jimmy Jones, at the same club:
Ultimately, Thomas got a number of opportunities to record and to perform, so that a few people still remember him, but it’s sad that his work is so difficult to find. He deserves so much more.
This entry was posted in Irreplaceable, It's A Mystery, Jazz Titans, Pay Attention!, The Real Thing, Uncategorized and tagged Al Hall, Albert McCarthy, Art Kane, Art Tatum, Babe Mathews, Barney Bigard, Benny Carter, Benny Morton, Bernard Addison, Big Joe Turner, Bill Coleman, Bing Crosby, Bix Beiderbecke, Bobby Hackett, Brew's, Buck Clayton, Bud Freeman, Buddy Tate, Bugs Hamilton, Cafe Society, Chu Berry, Claude Hopkins, Coleman Hawkins, Cootie Williams, Cozy Cole, Dave Tough, Dill Jones, Doc Cheatham, Don Byas, Duke Heitger, Earl Hines, Ed Hall, Eddie Condon, Emmett Berry, Fats Waller, Fats Waller and his Rhythm, Fletcher Henderson, Frank Newton, Fred Rich, George Wettling, Harry Lim, Herb Hall, Herman Autrey, Hot Lips Page, Hot Record Society, HRS, J.C. Higginbotham, Jack Fine, Jack Teagarden, James P. Johnson, jazz blog, Jazz Lives, Jimmie Lunceford, Jimmy Andrews, Jimmy Jones, Jimmy Rushing, Jo Jones, Joe Thomas, John Hammond, Johnny Guarneri, Johnny Williams, Joseph Eli Thomas, Kenny Davern, Keynote Records, Lester Young, Lil Armstrong, Lil Hardin Armstrong, Louis Armstrong, Max Kaminsky, Maxine Sullivan, Michael Steinman, Mike Burgevin, Milt Hinton, Mosaic Records, New York jazz, Nicholas Payton, Pee Wee Russell, Red Allen, Rex Stewart, Roy Eldridge, Ruby Braff, Rudy Powell, Sidney Catlett, Stu Zimny, Stuff Smith, Sweets Edison, Ted Nash, Teddy Wilson, Tony Scott, Trummy Young, Whitney Balliett, William P. Gottlieb, Woody Herman. Bookmark the permalink.
33 responses to “REMEMBERING JOE THOMAS”
wamp wamp | June 12, 2009 at 1:11 AM |
A-MEN!!
Joe’s solo on ‘How High the Fi,’ in one of the Buck Clayton’s Jam Sessions, is one of the most noble moments in jazz. Pure majesty, backed up by a great rhythm section and Trummy’s riffs. Nobody said so much with so few notes!
Agustín Pérez | June 12, 2009 at 4:17 AM |
Thanks a lot for that wonderful portrait of the great and sadly underrecorded Joe Thomas!
Regarding post-1946 sessions leaded by Joe Thomas, the Atlantic 1958 session promoted by Albert McCarthy that you mentioned, which produced the LP called “Mainstream”, has one side by Joe Thomas & his All Star Group: Joe Thomas, Johnny Letman (tp) Dickie Wells (tb) Buster Bailey (cl) Buddy Tate (ts) Herbie Nichols (p) Everett Barksdale (g) Bill Pemberton (b) Jimmy Crawford (d). The other side has a group leaded by Vic Dickenson, with Buck Clayton and Gene Ramey.
Also, Bruyninckx lists two 78 rpm discs on a Seeco label (10-001 & 10-007) by Joe Thomas & Babe Matthews, with Lem Davis on alto sax, Ken Kersey on piano, Billy Taylor on bass and JC Heard on drums, recorded c.1953.
Agustín Pérez
Chris Albertson | June 12, 2009 at 9:11 PM |
Let me echo Augustín’s thanks for the Thomas piece. BTW, the man on Thomas’ right (in the first photo) is my old room mate, Timme Rosenkrantz. In the Sixties, Timme and Harry Lim worked together as sales clerks in the main Sam Goody store. Neither man belonged there and I used to wonder if jazz customers were aware of the expert help they were getting.
Pat Carroll | June 13, 2009 at 10:53 AM |
I do not have the Keynotes but do have one 45 RPM Mercury EP-1-3101 Roy Eldridge and his Trumpet Ensemble which included Eldridge plus Thomas and Berry doing four extended play tunes………..I haven’t listened in years trying to keep this old 45 in good shape……..
I have a 45 RPM from Mercury…EP-1-3101 Roy Eldridge and his Trumpet Ensemble which was Roy plus Thomas and Berry with Guarnieri, piano, Israle Crosby, bass and Cozy Cole, drums. No date but I would guess it to be mid-fifties. St Louis Blues, Don’t be That Way, I Want to be Happy and Fiesta in Brass. Looks like it was part of a series becausee the EP is called Vol 8 ??
Jon-Erik | June 13, 2009 at 3:45 PM |
yeahyeahyeah, what he said!
(which he? take your pick.)
John Herr | June 14, 2009 at 2:07 PM |
You don’t identify the others in the 1st photo, but Harry Lim is 4th from left, next to the would-be drummer (who resembles bassist Red Mitchell). The man on left about to tap cymbal looks a little like trumpeter/arranger Neal Hefti. Could it be?
jazzlives | June 16, 2009 at 8:55 AM |
Well, anything is possible. One of the men in the photo is a Belgian, Yannick by name, whose identity I omitted — with apologies. The photo comes from the William P. Gottlieb collection at the Library of Congress, which has minimal and occasionally inaccurate identifications. What matters is how young and cheerful Thomas looks!
Extended Play recordings like that hail from the middle Fifties, during the battle of the speeds and sizes between record companies, but the music itself is from 1944. And wonderful, too!
You roomed with the Baron? I am sure that there’s a chapter in there somewhere, Chris. Are you writing an autobiography or might I ask you about Timme for a future posting?
I had forgotten about MAINSTREAM, which is a serious error, as it’s the only post-78 session under Thomas’s name, even though he shares credit with Vic Dickenson (not a bad thing) for the other part of the lp. Incidentally, more titles were recorded by Vic’s band — among them the naughtily titled UNDER PLUNDER BLUES — but a fire in the Atlantic vaults, I am told, destroyed them. A pity! As far as the Seeco sides are concerned, I think that the dating is in error and that they come from 1946. I once heard them, courtesy of the late Bill Coverdale, who loved Joe’s playing as much as I did and very generously made tape copies available of his substantial JT collection.
Chris Albertson | June 16, 2009 at 9:25 AM |
I am writing an autobiography, but don’t let that hold you back if you wish to ask me questions about Timme.
Michael Burgevin | June 16, 2009 at 3:28 PM |
Dear Michael. Wonderful that you write about this great trumpeter who was also such a kind, gentle man. Sitting behind him nights, which was something special in itself, I could see a very deep scar on the back of his neck and I believe this was from the taxi cab accident he and Bud Freeman were in. I remember Herb Hall telling me this story and the fact that Joe was never quite the same after that shake-up. I think Herb was referring to things other than his playing. Jimmy Andrews loved his playing as I did. In that trio at Brew’s, when Joe was guest there for the week, it was very different! He could/would use one note and say a whole sentence. To hear him play/sing “Talk of The Town” or “People Will Say Were In Love”– well it was just marvelous! Like nothing else! He was a gift to us all.
Patty and I went to see him at Newport in New York where the setting was a big band and if my memory serves me right Benny Carter was the leader and Maxine, vocalist. There was Joe up in the trumpet section and the back up “rolls” he put down behind her were so beautiful. Ed Beach broadcast that later during his show. Heading out to gigs with him he’d have some homemade chicken sandwiches– with mustard. Well, I’ll sign off here– Take care MS– mb
jazzlives | June 16, 2009 at 6:32 PM |
One of the great pleasures of blogging is being able to share ones joys . . . and having old friends come in to join the discussion. Michael Burgevin, for those not in the know, is one of the finest jazz drummers I’ve ever heard — the sound of his four-bar hi-hat introduction and dramatic rimshot to bring in a performance is something I hear as I write these words. A witty, generous man in many ways (along with his gracious wife Patty!) — ways I haven’t forgotten. Hats off to you!
Joe Muranyi | June 18, 2009 at 2:55 PM |
Got the nice article on Joe Thomas from a friend. I played with Joe many times- adored his playing. I hired him for my gigs around NYC. Joe or Johnny Windhurst (George Wettling on the drums). He sometimes subbed for Roy Eldridge at Jimmy Ryans In that case I led and picked the tunes. Sober, Joe was up to anything. But after a few drinks he got reticent and didn’t seem to want to play; though he still was in pretty good playing shape. Never saw him get nasty or anything- he just didn’t seem to want to play. The phenomenon was very noticeable.
I heard that story about an accident changing him. Since I didn’t know him before it I can’t say if there was something to it.
He said a lot with very few glorious notes. He really trumpeted those strong and true ones. Could he edit himself! Perfection.
I remember a gig for some big Wall Street type in a private suite of a Fifth Avenue hotel. It was an annual affair and since Omer Simeon had passed I inherited the gig. The others were Joe Thomas, Benny Morton (or was it Vic Dickenson?), Sonny White-pno, Al Hall-bass. and Manzie Johnnson-dms. Quite a band. We played some ballad and I did my best on my chorus. Joe followed me and blew about one twnty fifth the number of notes than I had. Gloriuos. I felt the fool; quite a lesson. Joe was so good- consumate! When he was on he was on.
The Babe Matthews referred to in one of the comments was Joe’s wife. She sang. He talked a lot about her. I never heard her sing.
I’m just delighted to hear that there are others who dug brother Joe! A talent like his will never be forgotten.
Joe Muranyi
Bo Scherman | June 24, 2009 at 4:52 AM |
Good to see your tribute to one of my favorite trumpet players, Joe Thomas.
I have identified two more people in the picture from “The Pied Piper” with Joe Thomas and Harry Lim. Second from left is the Danish baron, jazz producer etc Timme Rosenkrantz, and the drummer is Frank Bode. The picture was published in Timme’s autobiography “Dus med Jazzen”. According to the author, it was taken at “Cafe Bohemia”, but his memory for details was not always accurate. Frank Bode (1923-1980), whose original name was Uffe Baadh, was born in Denmark and emigrated to USA in the summer of 1947. He played in a trio with Benny Goodman and Jimmy Rowles, with the Swedish clarinet player Stan Hasselgard and with the orchestras of Claude Thornhill and Harry James, among others. Later he played in studios and local gigs in Southern California.
Bo Scherman
Robin Aitken | February 23, 2010 at 10:59 AM |
I’ve just discovered your website as a result of seeing the post “Joe Thomas Remembered”.
For many years now Joe has been my favourite trumpet player. I bought the record “Mainstream” second-hand from a little record and bookshop in Glasgow in the early 1960’s and have loved his playing ever since.
I was lucky enough to acquire the Keynote box set issued by PolyGram in the 1980’s as this contains the best playing of Joe’s career. There are so many wonderful sides in this set featuring Joe that it is difficult to pick one over another. My personal favourite is the wonderful version of Ellington’s “Black Beauty” recorded in August 1946 with Tyree Glenn, Hilton Jefferson and Jerry Jerome with Bernie Leighton on piano Billy Taylor on bass and Lee Abrams on drums. A close second would be “Pocatello” (based on the chords of “Idaho”) from the same session. There are however many more wonderful moments in the Keynote set including the George Wettling’s New Yorkers session with Hawk and Jack Teagarden. He is also featured in Little Jazz (Roy Eldridge) Trumpet Ensemble with Roy and Emmett Berry in January 1944.
I was lucky enough to visit New York in 1972 for the first Newport in New York festival. A group of us from London, mainly associated with Dobell’s Jazz Record Shop in London’s Charing Cross Road, stayed at the Edison Hotel and attended many concerts. One of these was the Benny Carter Swingmasters band at Carnegie Hall on the 2nd July 1972. The personnel is worth repeating:-
Benny Carter ( leader and alto); Harry Edison, Joe Thomas, Jimmy Nottingham, Carl Warwick (tpts); Earl Warren, Howard Johnson (altos); Budd Johnson, Buddy Tate (ten); Haywood Henry (bar); Dickie Wells, Benny Morton, Tyree Glenn, Quentin Jackson (tmbs); Teddy Wilson (pno);
Milton Hinton (sbs); Bernard Addison (gtr); Jo Jones (dms).
We sat through both sets at the Carnegie Hall and it was one of the most wonderful evenings of jazz I have ever experienced. After I returned to London a friend of mine gave me a copy of a cassette of part of the concert which was apparently taped off Swedish Radio. The sound is not particularly good and Joe Thomas is not featured as a soloist on the tracks on the cassette. I do remember him in the actual concert on “Sleep”.
When I was in New York I had the good fortune to meet Don Redman’s widow and also Joe’s wife Babe Mathews at Cecil’s Tavern near Jimmy Ryans at the top of West 57th Street,( if my memory serves me correctly). Babe was a lovely lady. She recorded with Joe on two sides on the HRS label on the15th February 1946 with Joe, Lem Davis (alto), Ted Nash (ten) Jimmy Jones (pno), Billy Taylor (sbs) and Denzil Best (dms). The sides were “No Better For Ya” and He’s Got So Much”
Thank you again for evoking wonderful memories of a great trumpet player with a wonderful tone and an elegant simplicity of ideas.
jazzlives | February 23, 2010 at 11:12 AM |
Dear Robin,
You are someone after my own heart — BLACK BUTTERFLY was and is perfection (passion and control together) and I was at both shows of the Benny Carter Swing Masters. And (as we say) how about Joe on the Tatum Decca session? He was a great player who should be better known.
Do you have the English RCA Vic Dickenson lp (produced by Albert McCarthy) that includes Joe? He sounds fine there . . .
Happy to have you as a reader and thanks for sharing your memories! Michael
Thank you for the welcome. Regret I don’t have the English RCA of Vic Dickenson with Joe.
Apologies for my error. Of course it is “Black Butterfly” not Black Beauty!
jazzlives | February 23, 2010 at 1:44 PM |
Apologies not necessary — it was a sbuliminal wish that Joe had played that Ellington song, too. But his melody statements on BLACk BUTTERFLY are imperishable singing utterances, aren’t they? And there’s SHE DIDN’T SAY YES and his work on the Little Jazz Trumpet Ensemble . . . and SHOULD I with Don Byas. Bless Harry Lim, though — he loved Joe and Sidney Catlett and as a result the Keynotes are touching monuments to the true Swing feel. Cheers, Michael
Jack Rothstein | July 30, 2010 at 3:51 AM |
I was an avid listener in NYC in the 50’s and early 60″s. Then, the only trumpet player around who could match Joe Thomas on a ballad was Bobby Hackett.
Joe Thomas was also Frankie Newton’s favorite jazz trumpet player.
Meredith | September 27, 2010 at 10:48 PM |
Thank you so much for this wonderful article on my Great Uncle, Joe Thomas. I shared this article with my family, and we were so excited to find out the details of his recorded work. We had no idea where to start to obtain his music until you provided us with such valuable information. I cannot wait to start the search and put together a full compilation of tracks from our beloved Uncle Joe.
Even though I was young when he passed, I still have fond memories of my Uncle Joe and Aunt Babe when they would come to St. Louis. My sister, brother and I would listen absorbedly to their electrifying tales of New York and all it had to offer.
Thank you again from me and my family for sharing your memories.
Angela | May 26, 2011 at 8:54 PM |
Joe Thomas was my great uncle, not only was he a great musician he was a great man!!
Myron Verne | December 24, 2011 at 9:23 AM |
Sorry for my French accent, even in typing English :_) , but I can’t resist adding a few lines to this wonderful tribute to one of my prefered trumpet men! Black Butterfly is one of my all times favorites, too, and I could not praize highly enough his work with Art Tatum, but I’d like to underline a session it seems nobody else mentioned:The Big Reunion,- Fletcher Henderson All Stars in Hi Fi, a 1957 (or 58) star-studded big band, pushed by the infectious rhythm of james Crawford drums,and directed by Rex Stewart, including such former Henderson Alumni like Coleman Hawkins and Ben Webster, Buster Bailey, on trombone Higgy and Benny morton and Dicky Wells,also Hilton Jefferson, Al Casey…and a trumpet line of Rex, Emmett Berry, Taft Jordan and…Joe Thomas. In this hard swinging and greatly recorded session in Hi Fi, Joe Thomas blows some of the best solos in his immediately recognizable style and gorgeous tone.
Thanks to all you bloggers, who had me listening again to all these gems!
Oh, and I forgot to say that I think the Belgian guy mentioned by Jazzlives in the Library of Congress Pic with Joe Thomas, is likely to be Yannick Bruynoghe, a great Jazz and Blues fan who wrote many texts in magazines, and also co-wrote Big Bill Blues, Broonzy’ s autobiography as told by himself..
Brew | June 12, 2012 at 9:55 PM |
Thanks so much for this article, Michael. A labor of love. — Joe Thomas, a very delicate trumpeter indeed; reminds me a lot of Buck Clayton.
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Andre Luckett | April 10, 2013 at 9:15 PM |
This is my Uncle joe he was married to my aunt babe Thomas such a wonderful and talented couple so many storys of their music careers all I can say is wow to them both
Pingback: “POCATELLO,” or SWING LYRICISM, 1946 | JAZZ LIVES
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Ryo | August 15, 2018 at 5:03 AM |
Hello ! Is this horn player Joseph Eli Thomas, the sitter of that trumpet player Joe with his wife May, taken by the French photographer Henri Cartier-Bresson in 1935 in New York?
Hello ! Is this horn player Joseph Eli Thomas, the sitter of that picture featuring thetrumpet player Joe with his wife May, taken by the French photographer Henri Cartier-Bresson in 1935 in New York?
jazzlives | August 15, 2018 at 8:24 AM |
I’m not sure what photograph you are referring to. Joe’s wife was the singer Babe Matthews. Do you have a Cartier-Bresson photo of Joe?
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by JCPConnect- December 18, 2020
By Sophie Bloch, Director of Hillels of Memphis
Over these last few months, I have often thought back to my own college experience and what it would have felt like to be starting a new school year during a pandemic. I studied dance and theater, so time and time again I came back to the age-old adage that “the show must go on.” And go on, it did! In spite of physical distancing and students scattered around the country, we were still able to honor the essence of what makes Hillel.
After an incredible pilot Jewish Learning Fellowship (JLF) series in the spring, twenty students participated in JLF this semester. Because JLF was virtual this semester, we were able to combine students from Rhodes College and University of Memphis into one cohort to learn together. The pandemic has put many other quintessential college activities on pause, which has left more availability for more people to participate in Jewish learning; many of the students taking advantage of virtual JLF this semester otherwise wouldn’t have been able to participate due to their class schedule, athletics, or work obligations.
We also launched a virtual learning series with Jewish faculty from Memphis universities to spotlight the incredible Jewish intellectual talent we have here in Memphis for the entire Memphis Jewish community to enjoy. Named “On One Foot” in honor of the parable about Hillel the Elder teaching a student the “entire Torah while standing on one foot: treat others how you’d like to be treated,” each program in the series features a Jewish academic speaking on their area of expertise. Each lecture was recorded and archived on the Hillel website so future learners can enjoy the lectures as well.
(Above) Professor Victor Coonin, Professor of Art and Art History at Rhodes College, spoke about “Michelangelo, Moses, and Black Lives Matter” to discover what Michelangelo’s depictions of Moses can teach us about contextualizing problematic statues from the Civil War era.
Crisis calls for Jews to step up, which is something eight Hillel student interns learned this semester during a new Fundraising and Development Internship in partnership with Memphis Jewish Federation. Students learned about the Jewish values of philanthropy as well as valuable communication skills for fundraising that will translate to any future career, all while having the opportunity to get paid for remote work. The students in this leadership role set the tone for meaningful involvement in Hillel and Jewish communal life for their peers, all while Memphis Jewish Federation got support from students in securing pledges for its Annual Community Campaign.
Even though classes were virtual this semester, many students were living in Memphis either with their families or in their off-campus apartments. Because of this, we hosted small outdoor socially distant Shabbat dinner celebrations at the Morris S. Fogelman Jewish Student Center at University of Memphis. In-town students from both campuses came together to safely celebrate Shabbat and holidays together, providing a much-needed opportunity for connection and spirituality.
The semester wouldn’t have been complete without Hillel swag- and the best part about Hillel swag is that it travels! Without the usual milestones to mark time, we benchmarked the semester with care packages that were either mailed or hand-delivered to students in honor of the start of the semester, Rosh Hashanah, and finals week. As a result of receiving care packages throughout the semester, students felt included in the Hillels of Memphis community no matter where they were spending their semester.
Whether it was through remote learning opportunities, leadership development, outdoor Shabbat and holiday celebrations, or receiving goodies in the mail, Hillel students brought their best selves forward. We have so much to learn from the compassion, dedication, and resilience of our young adult community, and now more than ever I am confident that the future of the Jewish people will thrive in their hands.
Tags: Hillel at Rhodes College, Hillel Memphis, Hillel Rhodes College, Hillel U of M, Hillel University of Memphis, Hillels of Memphis, Hillels of Memphis Rhodes, Hillels of Memphis Rhodes College, Hillels of Memphis University of Memphis, Jewish Community Partners, Jewish Federation Memphis, Jewish Foundation of Memphis, Jewish life in Memphis, Jewish Memphis, Jews in Memphis, Memphis Jewish Community, Memphis Jewish Federation, Memphis Jewish Federation Campaign, Memphis Jewish Foundation, Memphis Jewish life, Memphis Jewish Population, Memphis Jews
Miriam Roochvarg Joins Jewish Community Partners Team to Oversee PJ Library, Israeli Scouts, and More
by JCPConnect - September 22, 2020
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How Consumers Forced Big Merchants To Up Their Digital-First Game
Oct 5, 2020·10 min read
Human beings are creatures of habit.
Take popcorn and going to the movies.
Americans consume roughly 13 billion quarts of popcorn every year, roughly 30 percent of that at the movies. Well, that was back when theatres were open, before COVID, and going to the movies was a regular part of a consumer’s routine.
But in those good old days of 10 months ago, digging into a tub of popcorn while watching a movie on the big screen seemed an inextricable part of the movie-going ritual — and theater owners kept that popular snack at the ready.
And for good reason. Margins on concessions sales, including popcorn, are as high as 85 percent, and can account for as much as 46 percent of theater owners’ profits.
In 2014, scientists wanted to determine how much of a ritual eating popcorn at the movies is for the American consumer. They did a study in which they gave consumers two different buckets of popcorn to taste — one stale and one fresh. Consumers, naturally, preferred fresh to stale, until they were randomly given buckets of fresh and stale popcorn at the movie theater. There, researchers found that of the consumers who typically ate popcorn at the movies, just as much of the stale popcorn was eaten as fresh.
Old habits are hard to break — even, apparently, when it comes to eating lousy-tasting popcorn.
This finding, though, is just another data point in the growing body of evidence to prove how habits and context shape the ritual of a person’s regular routine. Habits deliver certainty — and the more routine the activity, the more incentive people have to shortcut the process of deciding what to do every time they do it. Scientists say that 40 percent of the 12 primary activities that account for the typical person’s day-to-day norm are largely done on autopilot, the repetition of tried-and-true behaviors that deliver a predictable and satisfactory outcome.
Since the early part of the year — the middle of March, for those living in the U.S. — people all around the world broke with the habits and rituals that once defined their daily routines across all 12 of those activities. First, it was partly out of necessity, as governments locked down the physical economy — but now, it’s increasingly out of choice, as the duration of the pandemic continues and consumers’ concerns over their personal health and safety remain high.
These digital-first consumers, this new digital advance guard, define certainty and predictability in new ways. The once tried-and-true habits introduced frictions, and no longer provided the satisfactory outcome they once did.
New PYMNTS research suggests that this shift to digital now foreshadows a more permanent change in how consumers shop and even order and eat food at restaurants. These are the results of the thirteenth study PYMNTS has conducted since March 6. Each study examines consumer behavior about the shopping and dining behaviors of a national sample of now roughly 30,000 U.S. consumers, as well as the behavior of a sample of Main Street business owners.
What we have learned is that health-first has accelerated the consumer’s shift to digital-first, and continues to influence to whom the consumer turns to build those new habits.
That has forced merchants to break their own habits, and to meet consumers where and how they want to shop, pay, order and eat their food.
On their very digital-first, touchless turf.
Consumers are also quite willing to put their money where their mouth is.
A third of consumers, some 70 million Americans, now report that they are very or extremely likely to select a merchant based on the availability of suitable digital, touchless offerings — a number that swells to more than two-thirds (69 percent) when adding those who said they were also somewhat likely to do so.
Likelihood of choosing a merchant based on digital capabilities (slide 21)
Follow The Consumer
Merchants have gotten and read that memo.
The national study PYMNTS fielded to 2,157 adult consumers between Sept. 10 and Sept. 15, then some 181 days into the pandemic, found a consumer whose digital-first experiences with merchants have gotten better.
In fact, on average, consumers report that their experiences are a lot better.
Using digital-first channels to shop for retail products and order food from restaurants using aggregators is two to two-and-a-half times better than consumers reported just three months earlier, at the end of May. For grocery, consumers report that their digital-first and touchless experiences are now nearly two times better for that same time period.
Percentage that shifted to digital in different activities (slide 4)
Delivery (66 percent), curbside pickup (58 percent) and inventory availability (55 percent) top the list of the experiences that consumers say they value the most. Interestingly, when asked to rank in order the capabilities of greatest importance, inventory availability tops the list. Part of reducing shopping friction is knowing whether items are available when consumers want to buy them. Lower on the list is the acceptance of digital wallets, even though consumers report more merchants adding that capability.
Copy: Digital capabilities consumers think are important for merchants to provide
And they have definitely added capabilities.
Seventy-nine (79) percent of consumers report that the merchants they shop with have added or improved their digital-first and touchless experiences over the course of the pandemic, with curbside pickup (55 percent) and contactless payments (51 percent) as the two features that consumers say more merchants have added as shopping and payments options.
Added digital capabilities (slide 20)
Naturally, the more digital-first and touchless capabilities merchants offer, the more likely consumers will make those capabilities — and those merchants — part of their new digital-first routines.
The number of consumers who report missing the physical store shopping experience have dropped by 20 percent since April. And as fond as consumers are of the restaurant experience, 10 percent fewer now say they miss eating at one.
What seems increasingly, perhaps even overwhelmingly, clear is that as merchants continue to add new experiences and align them to what consumers want, those consumers will have little reason to “go back.”
How many shifters plan to maintain their behavioral changes
The same goes for retailers.
In this latest study, PYMNTS finds that 85 percent, 84 percent and 80 percent of consumers who have shifted to digital for shopping for groceries, shopping for retail products and ordering food from restaurant aggregators, respectively, say they will stick with all or most of those habits moving forward, where “shifted digital” means a consumer is doing less in a physical channel and more in a digital channel for the same activity.
Shift — number of people and total spending (slide 15)
This is a finding that has been largely consistent over the course of PYMNTS’ 13 studies — even as retail shops have reopened and people have returned to shop in them, as restaurants have reopened and people have resumed dining in them, and as grocery stores (which remained open throughout) have become less friction-filled to shop in.
Digital-first will be how consumers engage, and how merchants reinvent themselves and their models — if they want those consumers’ business.
Based on the results of this latest study, PYMNTS estimates that now, some 84 million U.S. consumers representing some $1,025 billion of sales volume will shift some or all of their retail shopping, some 40 million U.S. consumers representing some $112.5 billion of sales volume will shift some or all of their food ordering and some 35 million U.S. consumers representing some $144 billion of sales volume will shift some or all of their grocery shopping to digital-first channels.
Those numbers will no doubt grow larger as the experiences offered by merchants get better and better.
Health-First Shopping Habits
What also remains remarkably consistent is the influence of health and safety on consumer decisions about where and how they shop, and order and eat their food.
With perhaps even more conviction than at any time we have observed since the pandemic began.
The latest PYMNTS study, conducted 181 days into the pandemic, finds a consumer who is slightly more afraid of dying from COVID as she was in April, at the height of it.
For many consumers, death from COVID has become more than a statistic reported by Johns Hopkins University, touching someone they knew firsthand or secondhand: the aunt of a co-worker, the brother of a neighbor, a longtime family friend. Even more people now know someone close to them whose family member had become extremely ill or had a terrifyingly close call.
In this study, we also observe a consumer who is now increasingly concerned about getting sick and missing an extended period of time from work.
As more is known about the long-term and lingering effects of the virus for those who survive it, consumers worry about their ability to perform their jobs, even if they get sick and recover. Those concerns are most acute for lower-income workers who lack both a personal savings safety net and options for employment should they be unable to fulfill the duties of a job they once had.
All of this contributes to a consumer whose timeline for feeling comfortable reengaging in the physical world continues to grow longer.
https://infogram.com/reasons-for-shopping-online-more-often-since-the-outbreak-slides-5-6-7-1hxr4z5715xy4yo?live
In September, most consumers said it would be 374 more days — until October 2021 — before they would be comfortable reengaging in the routines that defined their day-to-day activities: getting on an airplane to take a trip, going to movies and concerts, or engaging in any activity where lots of people are jammed into a single space.
That has increased 104 days since May.
Average days respondents think the pandemic will last (slide 12)
In fact, the fear of crowds is the primary reason why the majority of consumers say they continue to prefer a digital-first experience for shopping for groceries (57 percent), retail products (52 percent) and even ordering food from restaurants (45 percent). That’s up across the board for every one of those experiences since May as well.
Most important reason for concern (slide 3)
Digital-First, The Italian Way
Scientists say it can take anywhere from 15 to 254 days to form a new habit. For Italian consumers, it took about 150.
Italians are a physical-first shopping culture. Lack of broadband, an older population demographic, bad roads and a corresponding reluctance to put payments credentials online meant that at the end of last year, fewer than 40 percent of Italians had ever shopped online.
Between January and May, more than two million Italians got online for the first time, and 75 percent of Italians now shop online regularly. Experts project that online sales will reach 26 percent of all retail sales in 2020, up from 8 percent a year ago.
From all accounts, these digital habits are likely to stick as merchants and consumers see the speed, convenience and security that a digital-first experience can offer.
It’s easy to lose sight of the fact that, here in the U.S., the consumer has been dropping her digital-first breadcrumbs well before the pandemic raged. Between 2017 and 2019, analysts reported that roughly 23,144 physical stores had closed. Just last weekend, the popular fast-fashion chain H&M said it will close 250 stores in the U.S. due to a decline in foot traffic caused by the pandemic. UBS reports that 100,000 more stores could close by 2025. Analysts report that as many as 25 percent of the 1,100 malls still left standing will close by then, too.
Inertia is the irresistible force that meets the immovable object of the habits that guide 40 percent of a consumer’s daily activities, which took those consumers a long time to create. Disruption of that routine causes the sowing of the seeds of change. Suddenly, the actions that once defined those habits and created that good outcome are out of sync, or no longer work, or create friction.
But that alone isn’t enough to produce and sustain new habits.
People also crave certainty, and need to feel confident that the disruption isn’t just a temporary blip or a small break in the action that will soon right itself, but a disruption that portends the potential for a more permanent change. People still must be convinced that changing their behavior — from what they used to do to something different — will produce a better outcome, and is worth investing the time and effort to make it their new routine.
The pandemic has forced consumers to make that shift, even in places where digital isn’t a well-developed skill. But today, unlike the ritual of movie theaters and stale popcorn, consumers don’t have to accept what merchants are serving if it doesn’t fit with their newly formed shopping and dining preferences.
Some merchants are doing better than others — the enterprise merchants, in particular, are capturing more of the consumer’s attention and spend. Part of that is because they have the resources to make a quicker pivot, or maybe they think they stand to lose more if they don’t. In some cases, like retail and restaurants, it’s because they are open for business. Many of the Main Street businesses, which were once options for consumers, have closed or operate with limited hours and inventory.
As we have also seen, a lot can happen in a few weeks, or even a few days. In the U.S. and many other parts of the world, the virus is reemerging and positivity rates are climbing. In just the last few days, the president of the United States and many of his inner circle and senators have tested positive. So have NFL players and coaches. Colder weather will force more people indoors, which, combined with the onset of flu season, could increase the risk of contagion.
One thing we’ve seen consistently over the last six months is that every time we do a survey, people — in processing all of the information associated with what’s going on — predict that it will take longer than the last time we asked for things to get back to normal. Given what’s happening in the U.S., and given the resurgence of the pandemic in places around the world that seemed to have gotten it under control, it is possible that the old normal will never return, and that a new, digital-first normal will become entrenched.
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home » JIS News » National Security
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NLA New Online Survey Platform January 13 2021
Feature | Presented by: Anthony Morgan
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GOJ News | Presented by: Anjuii James Sawyers
Gov’t Appoints Boards To Supervise Juvenile Facilities
Written by: Chris Patterson
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The Boards of Visitors will give oversight to the operations of juvenile facilities, with the primary objective of ensuring that the children are protected.
The establishment of the Boards of Visitors is a direct response to the Armadale tragedy on March 22, 2009.
Each Board will meet once per month.
The Government is continuing on its strategic path to protect and promote the rights and well-being of the nation’s children through the establishment of Boards of Visitors for juvenile facilities.
This was stated by Chief Technical Director in the Ministry of National Security, Karen Clarke-Davis, during a meeting for members of the Boards on November 21, at the Jamaica Conference Centre, downtown Kingston.
The Boards of Visitors will give oversight to the operations of juvenile facilities, with the primary objective of ensuring that the best interests of the children in correctional and remand centres are protected.
They will monitor the operations of the Metcalfe Street Secure Juvenile Centre; Rio Cobre Juvenile Correctional Centre; Hill Top Juvenile Correctional Centre; South Camp Juvenile Correctional and Remand Centre, and ensure that they meet minimum standards.
Mrs. Clarke Davis said the Ministry remains resolute in safeguarding the wellbeing of all of Jamaica’s children, in particular, the 275 who are currently in the care of the Department of Correctional Services (DCS).
“The Ministry accepts the task of protecting the interest and welfare of our juveniles is a mammoth one and believes that the development of our nation requires a multi-faceted and collaborative approach,” she said.
She reminded the members of the Boards that they have the opportunity to influence the outcomes of rehabilitation programmes, to shape the reintegration strategy, and to contribute to the wards’ return to society as positive citizens.
“We look forward to receiving your recommendations and to a cordial working relationship. The children are our future, let us provide each one with every opportunity to excel and realise their full potential,” she stated.
The Chief Technical Director implored them to seek to make a difference and execute their functions with compassion, understanding and love for the children as they aim to protect their best interests.
“Discharge your functions without fear or favour but be friendly. Be thorough but thoughtful, be robust but be respectful. We must seek to do all in our powers to ensure that there is never a repeat of an ‘Armadale’,” she said.
Each Board, which will meet once per month, is mandated to submit reports to the Children’s Advocate, the Superintendent of the specified institution, the Commissioner of Corrections and the Minister of National Security.
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Cordero Scores 19, Cascade Snaps 6-Game Skid
Posted by Jeremy McDonald on January 18, 2020 January 18, 2020
TURNER, Ore.– The difficulties were there of course. Playing with eight girls is no easy task, especially on the back-end of back-to-back games as Cascade were on.
Mixed in that it’s back-to-back Oregon West Conference league games and the ante’s are amp’s up even more so than they would any other non-league back-to-back.
But here they were. Without Ariel Tobassion and Emma Clinton, both out with injuries, entering halftime up 20-18 on an Outlaw squad that rode into halftime on a 10-4 advantage after the Cougars 14-2 run to build a then 16-8 lead.
Cascade were looking to snap their six-game skid, the Outlaws the same on a similar seven-game skid as they enter the second half.
For the Cougars, it’s been hard without Tobassion in having that third guard body out there to feed off of. But coming off of their tough loss to Philomath Friday, Cascade knew they just had to grind and fight.
Natalee Federico (30) shadowing Sister’s Hallie Schwartz (12) during the first half of Saturday’s win (Picture By Jeremy McDonald)
“We struggle with not having a point guard out there. Like we have Kenna (Coleman) and me but we struggle having another one. Yeah they had more girls than us, I felt like we had to fight, it was all who wanted it more out there,” said Bailey Pedersen.
The game had the look as if the fourth quarter will be the deciding factor for the win and who had what left in the gas tank with the score at 27-25 in favor of the host Cougars Saturday afternoon.
And that’s when they made their move.
“We stepped it up big on effort in the third quarter. The third quarter are most important, we grinded in there,” said Pedersen. “Our number one goal is to get it inside and get it to our post and they were finishing for us today.”
Cascade outscored Sisters 19-4 over the final ten minutes of the game (Picture By Jeremy McDonald)
Abbigail Cordero was the workhorse in this game, going 7-for-7 at the line with 19 points in the game that helped open up her teammates. Pedersen hit a three to put Cascade up 32-25 entering the fourth quarter.
The Cougars pushed their lead to 11 in the fourth quarter and it held steady for the remainder of the 46-29 victory as they travel to Newport Tuesday before coming back to home court Friday night.
“It was good, we came out with energy which we’ve been struggling with and we executed well,” said Cordero. “It was good to see everyone step up, take on new roles and stuff like that, everyone did good.”
Emma Lutz finished with 12 points for Sisters.
4ACascade High SchoolHigh School Girls BasketballOSAA
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Ringo Starr shares details about his plans to celebrate his 80th birthday virtually with help from his friends
Credit: Scott Robert Ritchie
Yesterday, Ringo Starr announced plans to celebrate his 80th birthday on Tuesday, July 7, with a concert special called Ringo’s Big Birthday Show featuring Paul McCartney, Joe Walsh and other stars that will stream on YouTube at 8 p.m. ET.
During a Zoom press conference, Ringo explained how the event came together after his annual public “Peace and Love” birthday gathering — which usually takes place at the Capitol Building in Los Angeles — had to be canceled because of the COVID-19 pandemic.
“By February we were planning to do the whole thing all over again…a big party…but because of the pandemic…we had to think of something new to do,” Starr pointed out.
After first considering doing a virtual live concert using Zoom, Ringo said, “[W]e [eventually] decided that it’d be better to ask our friends to either do something new or give me some footage from one of their shows. So that’s how it’s working out now.”
Ringo revealed that he’ll be contributing a concert performance of The Beatles‘ “With a Little Help from My Friends” that he did last year with his All Starr Band.
“[I]t was a big celebration and a lot of other people who’d been in the All Starrs over the 30 years came and joined us onstage,” he explained. “So it’s really a cool end to the show.”
As previously reported, the Ringo’s Big Birthday Show lineup also include Sheryl Crow, Sheila E, Gary Clark Jr. and Ben Harper. The event will benefit four charities: Black Lives Matter Global Network, the David Lynch Foundation, MusiCares and WaterAid.
Also during the press conference, Ringo admitted he was disappointed that he can’t celebrate his milestone birthday as originally planned and that his 2020 tour with the All Starr Band was canceled.
By Matt Friedlander
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Rick Allen-hosted virtual benefit concert featuring Billy Idol, Tommy Shaw, Bret Michaels taking place Saturday
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Interview with Althea Swinford Hutton, March 28, 1975
Project: Fred M. Vinson Oral History Project
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Interview Summary
Althea Swinford Hutton was a friend of Fred Vinson's family in Louisa. She begins the interview by giving her impressions of Vinson's mother and family and how Vinson's mother was an influence on his life. She relates how her husband, Hubert, was picked to become an aide for Vinson when he first went to Congress as a political deal. Some of the political "bosses" in Cynthiana at the time are listed along with some of the deals they made. She mentions Hubert helping Vinson in Al Smith's presidential campaign and goes on to discuss Vinson's campaign style. She reminisces how her family and the Vinson family had to acclimatize to Washington. Vinson party loyalty is given as the reason Vinson supported Al Smith and subsequently lost the election. After that defeat, Hutton's husband decided not to return to Washington with Vinson in 1930 when he won re-election. She describes Vinson as being ambitious, but honest and feels that his relationship with Harry Truman helped him advance. She mentions how W. J. Fields opposed Vinson for a congressional election. She gives her opinion on his early political career and how she feels the stresses of his position contributed to his early death. She ends by mentioning Vinson's relationship with Virgil Chapman and the rest of the Kentucky delegation.
Interview Accession
1975oh018_vin014
Interviewee Name
Althea Swinford Hutton
Interviewer Name
Terry L. Birdwhistell
Interview Date
Interview Keyword
Fred M. Vinson Politics and government United States Government Campaigns Districts Strategy
Interview LC Subject
Law and legislation Vinson, Fred M., 1890-1953 Vinson family. Truman, Harry S., 1884-1972 Elections
All rights to the interviews, including but not restricted to legal title, copyrights and literary property rights, have been transferred to the University of Kentucky Libraries.
Interview Usage
Interviews may be reproduced with permission from Louie B. Nunn Center for Oral History, Special Collections, University of Kentucky Libraries.
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MLA: APA: Chicago:
Hutton, Althea Swinford Interview by Terry L. Birdwhistell. 28 Mar. 1975. Lexington, KY: Louie B. Nunn Center for Oral History, University of Kentucky Libraries.
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Hutton, A.S. (1975, March 28). Interview by T. L. Birdwhistell. Fred M. Vinson Oral History Project. Louie B. Nunn Center for Oral History, University of Kentucky Libraries, Lexington.
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Hutton, Althea Swinford, interview by Terry L. Birdwhistell. March 28, 1975, Fred M. Vinson Oral History Project, Louie B. Nunn Center for Oral History, University of Kentucky Libraries.
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Persistent Link for this Record: https://kentuckyoralhistory.org/ark:/16417/xt78gt5ff30d
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Kevin Card
A Music Journalist working to better the world of music.
Television Critique, The Walking Dead, Walking Dead
Walking Dead 6.10 Review: “The Next World”
Posted on February 23, 2016 by kevinthemusicguy
*Spoiler warning courtesy of Buzz Lightyear*
Hello again everyone, Kevin here bringing you the analysis on this week’s episode of The Walking Dead. I just wanted to let people know that the reason I always open up with a “filler” paragraph is so when I post these reviews to Facebook the text doesn’t bleed over and reveal any spoilers for those who didn’t want to see them. I like to consider it an extra insurance policy to prevent people from getting upset over spoilers.
Speaking of filler, I often hear comic book Gatekeeping fans get upset at the show every season due how slowly the story drags on. These people need to remember that these are two different mediums, and television shows need to reach syndication (100 or more episodes). It’s especially worth mentioning that lately The Walking Dead has returned to referencing the source material at a rate that I find to be appropriate. My main complaint about the show is that they add unnecessary story arcs that turn into filler arcs (source material aside) such as the corrupt police officers in the hospital from season 5A. Now then, onto the show.
This week’s episode really had no way of topping last week’s episode, so we can consider this the calm after the storm has settled. That being said, a lot of awesome things still happened in last night’s episode of The Walking Dead. For starters, we finally got to meet the comic book character Raul Rovia (nicknamed “Jesus”). We saw Spencer put down Dianna’s walker with help from Michonne, and we also saw that Carl has no idea how to talk to women with how rude he was being to Enid. Lastly, I’m happy to see that Rick and Michonne are together now as a couple as I’ve recently been “shipping Richonne” (as the kids on Tumblr are saying these days). There were some things that bothered me about the episode, but I rather enjoyed it overall.
What I enjoyed:
It was great seeing how the characters interacted in this episode, Michonne helping out Spencer with his personal task of putting Deanna out of her misery (after being reanimated) and helping Spencer find out he still has a family with the people of Alexandria. It was awesome seeing Jesus interact with Daryl and Rick throughout most of the episode, and how they kept Jesus true to his comic counterpart at how skilled at sneaking and hand to hand combat that he is. I also enjoyed a lot of the dialogue as this was definitely a story driven episode, not an action driven episode. Lastly, it was amazing to see Rick and Michonne together, and amusing to see them both draw their weapons on Jesus while naked at the end of the episode. Some fan service for Walking Dead fans? Hell, I’ll take it! Now onto the things that bothered me.
What I didn’t enjoy:
I really felt like the writers had Rick and Daryl acting out of character this whole episode, I’m pretty sure Rick and Daryl should have been smart enough to know that they should have just driven straight back to Alexandria with that supply truck before stopping anywhere else. Yes they found Jesus (not biblically), but they also lost all of the supplies in that truck because they kept messing around to try and locate soda for Denise, and kept struggling to deal with Jesus. The truck wouldn’t have fallen into the lake (which was painful to watch) if Rick and Daryl had just done the sensible thing and gone straight back (which Daryl is usually known for in this show). I feel like that whole part of the story focusing on Rick and Daryl was just wasted time where they stopped acting their normal selves. Other than that it was a satisfactory exposition episode (that was unfortunate enough to have to follow the act before it).
So I’m looking forward to seeing next week’s episode of The Walking Dead and how the whole story with Jesus will play out. I should also note this is just about the part of the comics that I stopped reading at so I will either need to play catch up with the source material (I own Walking Dead compendiums one and two), or just ask that people not spoil the major story arcs that are coming up in the future. I’m also super curious to see what they do in the show with Negan.
For today’s featured song I was tempted to leave “Jesus Take The Wheel” by Carrie Underwood in honor of Jesus stealing the food truck, but musically it doesn’t scream “Walking Dead” to me. Instead I will leave you all with the Johnny Cage song “When The Man Comes Around” as the appearance of Jesus (Raul) means that bad things are going to happen this season when Negan finally appears.
-KCard
6.10 Review The Next World walkingdead
Walking Dead 6.9 Review “No Way Out”
kevinthemusicguy · February 23, 2016
Reblogged this on Kevin Card and commented:
Reblogging to share on my social media pages.
bookshelfbattle · February 23, 2016
Last season, Rick wanted to pretty much murder everyone in Alexandria. Now he wants to take in a thief who robbed him. Seems out of character or else his character has grown and changed. The truck scene was almost a comedy. Hooray for Richonne!
Indeed, I think Rick’s character development has had too many variables to it recently. Here’s to hoping that this change in Rick doesn’t spell trouble for the group later down the road.
Diego · February 24, 2016
You could say that Michonne got that long hard Rick.
-Ba dum tiss-
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Twins Ace Jose Berrios Trying to Refine Two of His Pitches
Jeff Thurn
Hannah Foslien/Getty Images
The Minnesota Twins season has been put on pause like all other MLB teams due to the COVID-19 pandemic, but that doesn't mean players aren't training during this downtime.
Twins ace Jose Berrios is doing exactly that as he is trying to refine two of his pitches for when the season resumes.
According to ESPN, during a Facetime call with the network, Berrios explained how he was working on his secondary pitches.
"Right now, I am focusing on throwing the changeup towards the glove side, which would be on the side outside the right-handed hitter. As it naturally runs for me, it would be on the arm side, from the middle towards the bottom. I want to improve it towards the glove side."
Berrios has a nasty four-seam fastball that he uses the majority of the time, so he is trying to refine his changeup and curveball with this extra time on his hands.
MLB players have had to resort to throwing into mattresses, fences and another makeshift catcher like devices as they practice social distancing.
Hopefully, for Twins fan, these two pitches are refined for Berrios and the All-Star pitcher becomes even more dominant in Minnesota.
11 Franklin Delano Roosevelt Quotes That Will Give You Hope
Source: Twins Ace Jose Berrios Trying to Refine Two of His Pitches
Filed Under: Jose Berrios, Minnesota Twins, MLB
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The River Fulda near Kassel
Menzel, Adolph
Monogrammed and dated lower right
– Gustl Böhler
– Kunsthandel Wolfgang Werner, Bremen
– Katalog der Ausstellung von Werken Adolf von Menzel’s im Künstlerhause Berlin, Berlin 1903, no. 8
– Adolph Menzel 1815-1905: Pastelle und Zeichnungen. Max Liebermann 1847-1935: Bilder der 70er und 80er Jahre, exhib. cat., Kunsthandel Wolfgang Werner in cooperation with Kunsthandel Sabine Helms, Berlin 1995, no. 2
– Werner Busch: ‘Menzels Landschaften. Bildordnung als Antwort auf die Erfahrung vom Wirklichkeitszerfall’, in Adolph Menzel 1815-1905. Das Labyrinth der Wirklichkeit, exhib. cat., Paris, Washington and Berlin 1996-7, pp. 457-68
– Cornelia Dörr: “Eine schöne Vereinigung der Meriten Krähwinkels mit den Prätenssionen von weignstens Berlin.” Adolf Menzel in Hessen, diss., Marburg 1997, no. 94
– Cornelia Dörr: Menzel in Kassel – Landschaft und Geschichte, in Jahrbuch der Berliner Museen. Band 41. 1999. Beiheft. Adolph Menzel im Labyrinth der Wahrnehmung. Kolloquium anlässlich der Berliner Menzel-Ausstellung 1997, pp. 91-102
The 1840s saw Adolph von Menzel’s work undergo a transition and a period of artistic experimentation. His extraordinarily multifaceted output included works such as the illustrations for The History of Frederick the Great (1840-2) – a series that brought him broad recognition and prefigured his celebrated cycle of history paintings illustrating the life and achievements of Frederick the Great. But it also embraced more informal pieces – private interiors such as The Balcony Room (1845, Nationalgalerie Berlin), subjects motivated by his interest in burgeoning urbanisation, as in the painting Building Site with Willows (1846, Nationalgalerie Berlin), and landscape motifs, for example Thunderstorm over Tempelhof Hill (1846, Wallraf-Richartz-Museum in Cologne). The body of around one hundred drawings which he made on a visit to Kassel and the surrounding area in the years 1847-8 may also be seen in this context.
In 1847, the Kurhessischer Kunstverein awarded him a commission for a history painting depicting an episode from the history of the Land of Hesse. He spent seven months – from early August 1847 to late March 1848 – in Kassel working on what would be known as the Kasseler Karton (Kassel Cartoon). He regularly interrupted painting sessions to explore the town and rambled in the environs of Kassel, tirelessly recording his impressions in his sketchbooks. Many of the sketches he produced are today ranked by experts as among his finest. One of the most remarkable sheets in the group is the present view. Made in 1848, it depicts the river and the Orangerie seen from the Fulda Roundel.
Menzel has chosen a raised viewpoint looking south-west across the river Fulda. The triangular area of shading in the foreground represents the massive enclosure wall of the Roundel seen at close range. The Roundel is all that survives of the ramparts of the former Landgraves’ Castle which was destroyed in 1811. Menzel had already chosen the Roundel as his viewpoint a year earlier for a sketch looking in the opposite direction titled River Fulda near Kassel (1847, Nationalgalerie Berlin) in almost identical format. Appearing on the river just beyond the wall is a barge which two boatmen are slowly steering towards a side arm of the river. In the background is the Karlsaue, an extensive baroque park bordered by bare poplars and plane trees partly obscuring the lightly sketched outline of the Orangerie. On the opposite bank scattered buildings are glimpsed through the trees. The eye is led from here towards a delicately defined background of hills. The chilly haze of a winter’s day hangs over the horizon.
Why is it that some critics have described Menzel’s Kassel drawings as ‘lustrous pearls and ‘superlative masterpieces’ and others have spoken of them as ‘his finest achievement’? It is Menzel’s avoidance of a decorative or veduta-like style of representation that distinguishes his landscape drawings from those of most of his contemporaries. In the present sheet he takes pleasure in observing nature for its own sake. He employs remarkable economy of means and great subtlety in his depiction of its transient effects – the sombre mood of a bitterly cold day, the sluggish motion of a large body of water, light penetrating a filigree network of bare branches. Complex reality is pared down to its essentials. The fragmental conception of the composition, the choice of an unusual vantage point and the perplexing foreground motif attest to his astonishing powers of invention. The immediacy of the image gives it a powerful sense of authenticity and engages the viewer in the visual experience. Although the unconventional character of Menzel’s drawings sometimes makes them seem unpolished their virtuosity never fails to fascinate and their timelessness is unchallenged.
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Kley, Heinrich
The Towers of the Munich Frauenkirche
Alley Salita del Grillo in Rome
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Devontae Cacok talks Summer League, training camp
by Chris Walton
Jul 12, 2019; Las Vegas, NV, USA; Los Angeles Lakers center Devontae Cacok (12) pulls down a defensive rebound during the second half of an NBA Summer League game against the Golden State Warriors at Thomas & Mack Center. Mandatory Credit: Stephen R. Sylvanie-USA TODAY Sports
The road less traveled is one that can lead you to some amazing places. Los Angeles Lakers rookie Devontae Cacok is steadying his route. Cacok spent his childhood in Riverdale, Georgia finishing his high school career at Alpharetta High School. After a decorated four years at North Carolina-Wilmington, the Lakers took interest in the high energy forward as an undrafted prospect.
It turns out that the Lakers made a hell of a move. Cacok ended his first Las Vegas Summer League averaging 11.8 points, nine rebounds, and two steals per game for the team. His impressive performance earned him an Exhibit-10 deal with the team.
Lakers Outsiders was able to catch up with Cacok during a busy off-season for some questions about his Summer League experience and what’s to come next season.
LO: Overall, how was your Summer League experience?
Cacok: Summer league has been a great experience for me. I always dreamed about playing in it and for it to actually happen, it’s just kinda crazy. But I enjoyed all of it, from meeting people to playing with my teammates and getting to know the whole Lakers organization and I plan to bring my experiences I learned on the court with me in the future.
LO: What was your favorite thing about it?
Cacok: My favorite thing about summer league is playing against other NBA players and trying to making a name for myself. There is great competition in every game and it was fun just playing hard and showing what I can do to help my team in any way possible.
LO: What was it like having the Lakers make you a contract offer?
Cacok: Having the Lakers make a contract offer to me felt unreal at first. After my workout, they had interest in me and it was just a blessing the way things have played out so far and the organization having this interest in me and making that offer. I’m grateful for the opportunity they have given me and I plan to continue to give it my all.
LO: What are you looking forward to the most during the season?
Cacok: The first thing that I am looking forward to this season is training camp. Being around some of the best players in the world is really like a dream. Seeing how they work and how much love they have for the game first hand, I feel like I can learn so much from these veterans.
Cacok will get the chance to carve out the role that many players such as Alex Caruso, David Nwaba, and Jemarrio Jones have turned into impactful minutes. As he relishes in a dream come true, we are wishing him the best of luck in the upcoming year.
Posted in EditorialsTagged 2019 Las Vegas Summer League, Devontae Cacok, Los Angeles Lakers
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TEACHER-TEEN SEX ROMPS
Married Wisconsin language arts teacher, 38, arrested for sex with teen boy student after husband secretly filmed their trysts
The disgraced educator is accused of having sex with the boy, after her husband secretly recorded the alleged sexual assault
Wisconsin middle school teacher Stephanie Pudlowski was arrested last week after police say her husband secretly filmed her having sex with a 16-year-old teen student, who she reportedly took in as her “foster son”.
The 38-year-old disgraced teacher is charged by Wisconsin authorities with sexual assault of a child placed in substitute care, sexual intercourse with a child age 16 or older and causing mental harm to a child, according to online records detailing her liaisons with the teen boy.
Stephanie was arrested at about 8:20pm on Friday, May 15, according to the Wausau Daily Herald, part of the USA Today network of newspapers.
Bond was set at $5,000 for Stephanie, a teacher of eighth-grade English language arts. After the sex allegations were made, she resigned from James Williams Middle School in Rhinelander, Wisconsin where she had taught the teen boy, according to the school district.
Oneida County District Attorney Michael Schiek filed a charge of sexual contact with a child age 16 or older and sexual assault of a child Monday afternoon in circuit court. Pudlowski, an eighth-grade English language arts teacher, has resigned, according to the school district. Oneida County Circuit Judge Michael Bloom set a $2,000 signature bond for Pudlowski on Monday afternoon and scheduled another hearing for June 15.
Rhinelander middle school teacher charged with sexual assault of a child resigns from job
The Daily Mail reports that Stephanie’s husband secretly recorded his wife’s alleged trysts with the boy at the home they shared in Oneida County, Wisconsin. Police say the audio and video in question show that the middle school teacher had a sexual relationship with the teen, whom she took in last year.
Stephanie Pudlowski reportedly met the school boy several years ago while teaching at James Williams Middle School in Rhinelander, Wisconsin; however police say no sexual contact occurred between the two on school property. The married teacher is said to have admitted to having sex with the teen victim after he came to stay at her home last year.
Stephanie’s husband, who filed for divorce on Monday, told authorities he installed cameras in the Oneida, Wisconsin house after suspecting that something sexual was going on between his teacher wife and their teenage foster child.
According to Oneida, Wisconsin police, the sexual trysts between teacher and teen had been going on for months. Stephanie initially claimed that she closed the boy’s bedroom door because he was a “loud gamer.”
He secretly recorded in the boy’s bedroom in the basement, according to the criminal complaint. That is said to have shown sexual activity between the two which police say has been going on for months.
Teacher, 36, is arrested for ‘having sex with 16-year-old foster son’, who used to be her student, after her husband ‘secretly recorded their trysts’
Later, Stephanie’s husband, suspicious of illegal sex by his teacher wife, also placed an audio recorder in the basement, where the foster teen’s bedroom was located, according to WJFW in Rhinelander, Wisconsin.
The criminal complaint against the teacher states that the audio recordings did depict some inappropriate sexual activity between the guardian and teen foster son, which occurred in Oneida, Wisconsin as often as “a couple of times a week over the last month.”
In an interview with officers, Stephanie said the teenager never asked for the sexual contact, and the teacher failed to answer police when asked if the child ever said no, WJFW in Rhinelander, Wisconsin reports.
Per the criminal complaint Pudlowski and the child were often alone in that room, with the door closed — which Pudlowksi says was due to the child being a loud gamer, and not always due to sexual purposes.The complaint states that recordings did depict some sort of sexual activity between Pudlowski and her foster son, which the complaint states had been going on for the last three to four months, and as often as a couple times a week over the last month.
Rhinelander teacher accused of mental harm and sexual assault to a child
Sexual assault of a child by foster parent is a class C felony, which is punishable by a maximum 25 years in prison and up to 15 years extended supervision.
Stephanie Pudlowski appeared in Oneida Co., Wisconsin court on May 18, where she was released on a $5,000 signature bond. The middle school teacher, now charged with serious sex crimes with a teen, will appear in Oneida Co. court again on June 15.
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No charges for actor Rick Schroder after abuse reports
LOS ANGELES (AP) — Prosecutors have declined to file charges against actor Rick Schroeder after an arrest on suspicion of domestic violence.
The Los Angeles County district attorney's office said in documents Tuesday that Schroeder's girlfriend on May 1 told a 911 operator he punched her at his home in Malibu.
But prosecutors say she was uncooperative with deputies when they arrived, and the next day said she suspected he hit her by accident because she startled him as he was sleeping.
They also declined to file charges after an arrest about a month earlier in an incident that Schroeder's girlfriend two days later called "a big misunderstanding."
The 49-year-old Schroder is known for starring in the TV series "Silver Spoons" and "NYPD Blue."
An email to his publicist seeking comment wasn't immediately returned.
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INDIAN FOOTBALL NEWS 2019 (JULY)
PRASUN BANERJEE FELICITATED WITH MOHUN BAGAN RATNA
KFC NEWS DESK - 29.7.19: It was in the year 1911 when Mohun Bagan created a history on 29th of July in the pre independence era in Indian football. The footballers of Mohun Bagan, who all played bare feet, faced the far-better trained East Yorkshire Regiment of the British Army by a margin of 2-1 in the final of the IFA Shield. Every year Mohun Bagan celebrates 29th July as MOHUN BAGAN DAY and felicitate successful sports personal.
This year Mohun Bagan awarded MOHUN BAGAN RATNA to the former Indian captain and Arjuna award winner Prasun Banerjee. The 64-year-old Prasun, who is the iconic footballer, was a prominent midfielder of his times. He played in three Asian Games in 1974, 1978 and 1982. He was part of an Asian All Star XI team. This is the first time to honor a non-footballer Keshav Chandra Dutt, winner of two-time Olympic gold medal in the field of hockey for India.
Arijit Bagui, the footballer of the current football team were honoured with Karuna Sankar Memorial Award for his outstanding performance in the year 2018-19. Ashoke Chatterjee, the ex international footballer were honoured with Life Time Achievement Award, whereas the U 19 football team, the winner of the Zee Bangla Football League with P Kannan Memorial Award.
A football match was organised where the ex-footballers participated.
PROGRAMME OF MOHUN BAGAN DAY - 2019
KFC NEWS DESK - 28.7.19 : MOHUN BAGA DAY 2019 SCHEDULE BELOW
EAST BENGAL STARTED CENTENARY CELEBRATION WITH A MEMORABLE RALLY
KFC NEWS DESK - 28.7.19 : East Bengal Club started it's centenary celebration with a torch rally from Kumortuli park at North Kolkata, the place from where Red and Gold started it's journey way back in the year 1920 from the house of Late Suresh Chardra Chowdhury. The rally ended at the club tent at Kolkata maidan where the torch was handed over to the club secretary Kalyan Mazumdar by the former India international footballers Subash Bhowmick and Baichung Bhutia.
The torch was lighten by the former footballers Sukumar Samajpati and Baichung Bhutia at Kumortuli park. It is indeed a memorable rally that Kolkata witnessed today. It can be reckoned as the largest sporting rally organised by a club in India and may be in abroad. Thousands of East Bengal fanatics of all ages along with the footballers participated in the rally to make it a successful and memorable one.
NEW JERSEY LAUNCED: RED & GOLD READY FOR THE CENTENARY RALLY
KFC NEWS DESK - 27.07.2019 East Bengal launched their new jersey on the eve of the clubs centenary celebration. The home as well the away jersey was manufactured by thekit sponcer of East Bengal Kaizen Sports.
The design of the jersey was from the concept of one of the oldest jersey of the club which was used in the year 1925 or 1926. The jersey was found from the house of Nepal Chakraborty, the footballer who scored the first goal against Mohun Bagan in the first ever Derby in the year 1925.
The centenary torch rally of East Bengal will start at 9am on Sunday from Kumartuli Park near the residence of Sarada Charan Ray from where Red and Gold starts it's journey in the1920. Thousands of East Bengal fanatics with decorative tablos along with the footballers are expected to join the eventful rally which will ends at the club tent at Kolkata maidan.
AIFF TOP BRASS NAMED IN AFC STANDING COMMITTEES FOR NEXT CYCLE
AIFF PRESS RELEASE- 25.07.2019 : Asian Football Confederation (AFC) has appointed AIFF top brass including the General Secretary, as well as Sr. Vice President to various AFC Standing Committees for the 2019-2023 cycle.
Mr. Kushal Das, General Secretary, AIFF has been included in the Finance Committee , whereas Sr. Vice President Mr. Subrata Dutta, has been made a member of the Marketing Committee. Furthermore, Mr. Sunando Dhar, CEO, I-League has been inducted in the Competitions Committee, while Mr. Ravi Shankar Jayaraman, also a former referee, and FIFA Match Commissioner, has been named in the Referees Committee. Jayaraman heads the Referee department of the apex body of Indian Football. Meanwhile, Mr. Abhishek Yadav, former India captain, and current National Team Director, has been included in the Technical Committee. Besides, Mr. Narendra Aneja Kumar was named in the Audit and Compliance Committee.
AIFF STATEMENT
AIFF PRESS RELEASE- 25.07.2019 : There are some media reports of a communication between FIFA and AIFF regarding the issues of Hero I-League and potentially a unified Indian Football League where a report of a consultation paper of FIFA and AFC in 2018 is being mentioned.
In the recent days, the AIFF President Mr. Praful Patel in his meeting with the Hero I-League clubs as well as in several recent interviews has broadly taken the same line as was suggested in the above-mentioned report.
Needless to mention that this is precisely the reason that a two-three-year window is required to resolve all contentious issues amicably with all stakeholders.
The question of Hero Indian Super League not remaining a closed league permanently has been clarified amply enough by the AIFF President, and promotion and relegation eventually would lead to the development of club football in India.
The AIFF is committed to engaging with AFC and FIFA as well as all other stakeholders for finding an early resolution to these issues.
FIFA WRITES TO AIFF AFTER GOKULAM KERALA FC AND 5 OTHER CLUBS REQUEST INTERVENTION
GOKULAM FC PRESS RELEASE - 25.7.19 As a response to the letter sent to FIFA President Gianni Infantino earlier this week by Gokulam Kerala FC and 5 other clubs, FIFA has written to the All India Football Federation seeking an update to the degree of implementation of the joint FIFA and AFC report that was prepared in 2018.
This report was made by conclusive research by a combined team of FIFA and AFC Delegates taking personal interviews with every major stakeholder in Indian Football. Official Delegates like Mr. Nick Crawford and Mr. Alex Philips from FIFA were specially flown to India to conduct intensive interviews with the major clubs in India to discuss on each and every issue the owners had in Indian Football.
The purpose of this report back in 2018 was to provide the AIFF with external expertise, a clear roadmap to establish a unified league and implement a widely-supported strategy for the development of football in India. This report was addressed to the stakeholders and not just AIFF who have kept this report with them for the past one year. This shows or rather proves that the report has solutions which do not coincide with the idea of AIFF or FSDL (the marketing partners of AIFF).
In this letter, FIFA CMAO Joyce Cook also confirms that they have been recently contacted by various top level football clubs from India in view of the ongoing fiasco in Indian Football and seeks acknowledgement on the development on the potentially unified "Indian Football League".
This was after Gokulam Kerala FC along with 5 other I-League clubs had written to FIFA President Gianni Infantino earlier this week requesting intervention on the deal that the AIFF made with FSDL. The letter also contained the sensitive MRA and up to 35 points explaining how the AIFF, through this deal, managed to ruin the already ill-treated clubs and further disrupt the future of the top league in India.
Gokulam Kerala FC and all other I-League Clubs ask Kushal Das and AIFF for the umpteenth time to release the report which consists of a clear road for the development of Indian Football which was sent by FIFA in 2018.
EAST BENGAL TO START CENTENARY CELEBRATIONS WITH TORCH RALLY on 28th July
KFC NEWS DESK - 17.7.19 East Bengal club will celebrate the 100 years of it's successful journey from 28th July onwards. In a press meeting at the club premises East Bengal officially announced the first three phases of the centenary programmes in presence of ex footballers and members. The Centenary Logo was released at the progamme.
In the opening Press Conference President Dr Pronab Das Gupta released the Logo. .Kalyan Majumdar Secretary,Dr Santi Ranjan Das Gupta Asst Secretary,Debabrata Sarkar Executive Committee Member,Bhaskar Ganguly,Manoranjan Bhattacharya and Baichung Bhutia addressed the Media. The centenary torch rally will start from Kumartoli Park on 28th of July, where the club was founded bySuresh Chandra Chowdhury way back in the year 1920.
The rally will start from Kumortuli Park and will end at the Club tent at Kolkata maidan. The second phase of the centenary programme will be on 1st of August.
The Red and Gold flag of East Bengal Club shall be hoisted and waved globally around 200 countries at 12 noon. The main events of the centenary programme will start at 5pm at Netaji Indoor stadium.
A host of footballers coach and Referees will be feliciated with awards.
LIFE TIME ACHIVEMENT AWARD TO LEGENDARY FOOTBALLERS:
NAUSHA SEN MEMORIAL TROPHY: BHASKAR GANGULY
BYOMKESH BOSE MEMORIAL TROPHY: MANORANJAN BHATTACHARJEE
BEST FOOTBALLER OF THE YEAR(2018-19)
BANWARILAL ROY MEMORIAL AWARD: LALDANMAWIA RALTE
IDENTIFYING & NUTURING THE ICON : BAICHUNG BHUTIA
COACH OF COACHES: PRADIP KUMAR BANERJEE
FELICITATION OF REFEREES : PRATUL CHAKRABORTY MEMORIAL TROPHY: RATANKUR GHOSH
PANKAJ GUPTA MEMORIAL TROPHY : SUNIL KUMAR MULLICK
Every year East Bengal felicitate an eminent sports personality with "Bharat Gaurav Award". This year former Indian cricket captain KAPILDEV NICHANJ will receive the prestigious award.
The other personalities who will be felicitated are Chief Minister of West Bengal Mamata Banerjee, Hon'ble Mayor Firhad Hakim, Actor Soumitra Chatterjee, Former Indian captain Saurav Ganguly .
Gadhinglaj United Football Association observed 10th Kole- Hatti- Shanmugam (Referee) trophy school football tournament
16.07.2019: MAHARASHTRA BASED Gadhinglaj United Football Association successfully complected it's 10th edition of Kole- Hatti- Shanmugam (Referee) trophy school football tournament. In this Tournament Sarvodaya School win the u14 and Gadhinglaj High School win the u-17 boys title. In This edition 24 teams participated where more than 500 kids participated at M.R. High school ground.
Tournament Organizer & club secretary Deepak kuppannva told that In the final of U-17 group Gadhinglaj High school defeated Jagruti High school by 2-0. Prashant Sawade and Kiran Rathod scored. In Semi final Gadhingalj High School beat V.D. Shinde High school by 5-0 & Jagruti High school beat Sadhana High School on sudden death 5-2.
In U-14 final Sarodaya school beat Kedari Redekar Public School on tie breaker by 3-1. In Tie Breaker Sarodaya's Pranjal Ravan, Tejas Koravi, Omkar Dhure & from Redekar school Shravan Jadhav scored.
In the prize distribution ceremony Rahul Powar, Aditya Sambhaji, Aniket Chougle, Sagar Banage ( All U17) Laxman Gurav, Omkar Dhure, Pranjal Ravan, Chinmay Yedave (All U-14) were felicitated as tournaments best player. For this prize distribution ceremony Tournament Co coordinator Sultan Shaikh, Jagruti High school Principal C.S. Mathpathi, United President Arvind Bardeskar, Director Bhairu Salwade, Sampat Savant, Pravin patil, Natha Regade, Ashish Patil, Pravin Rendale were present. In this tournament Omkar Ghagari, Omkar Sutar, Kuldeep Chavan, Ritesh Badame, Sagar Powar worked as referee.
AIFF PRESIDENT VOWS SUPPORT TO GROWING WOMEN'S FOOTBALL IN INDIA
AIFF PRESS RELEASE - 10.07.2019 : "All India Football Federation is extremely proud of you. I am very proud of you. The entire country is also very proud of you, All India Football Federation President Mr. Praful Patel told the Indian Senior Women's National team contingent in an official meeting in the Capital on Tuesday (July 9, 2019).
The Indian Women's National team squad are currently training in Delhi for preparation of the Cotif Cup later this month, and also the AFC Qualifiers scheduled later. "We have been focusing a lot on women’s football in our effort to bring glory to the sport. We know that one cannot improve without sufficient exposure. Hence, we have been stressing on exposure tours for the team. Till the time you play better teams, one cannot improve,” the AIFF President stated.
Since January 2019, the Indian Senior Women's National Team have been to Hong Kong, Indonesia, Turkey for exposure tours, and went into the AFC Olympic Qualifiers Round 2 on back of experience of having played 15 international matches in less than three months. The women also successfully defended their Women’s Senior SAFF Championship crown, and will now head to the Cotif Cup having played 18 international matches.
AIFF Women’s Player of the Year 2018-19 Ashalata Devi "thanked AIFF for all the support."We are very thankful for the exposure trips which helped us immensely. We are a much more confident unit now. Playing in Spain, and Turkey helped us to play at a high intensity," Ashalata quipped. Mr. Patel also mentioned about the impact the FIFA U-17 World Cup India 2017 have had on Indian Football, and maintained that he foresees women's football receiving a similar fillip as India are to host the U-17 Women’s World Cup in 2020.
"The U-17 Women's World Cup will be a significant step to improve women's football in India. You need to remember that the players who will play in the World Cup idolise you, and look up to you. It's you who inspire them," Mr. Patel explained. Former Indian National Team captain, and currently Director, National teams Abhishek Yadav felt the 'women's team have come a long way in the last one year."
"They have put up exceptional performances, and I would like to congratulate them for their achievements. I am also very confident that the federation, and the government will extend all their support for the team for the upcoming AFC Asian Cup," he said."You are a comparatively new squad. Utilise the exposure, and build up your career. The manner in which you have been playing has been commendable. You have to further move forward," Mr. Patel added. "It’s our duty to support you, and women’s football, and will."
"The changing character of Indian Football is reflected in your squad. I see many girls from the north eastern region of India in the team. The passion in the team is unmistakable. We want Indian Football to be broad based."
ISL would get a berth for the qualifiers of the AFC Champions League.
09.07.2019 - AIFF PRESS RELEASE : The AIFF Executive Committee met today (July 9, 2019) in Delhi and discussed various issues including the request letter that the champions of Hero Indian Super League would get a berth for the qualifiers of the AFC Champions League.
In light of the MRA as well as the fact that in the last 5 years the entire Indian National squad are mostly being signed/playing for the Hero Indian Super League clubs, and the TV viewership and in-stadia audience having grown far more substantially vis a vis the Hero I-League, and the Hero Indian Super League clubs complying with the entire AFC Club licensing criteria, including strong Grassroots, and Youth Development Programmes which had also been certified by the Asian Football Confederation, the AIFF Executive Committee recommends to the Asian Football Confederation to positively consider their request.
Further, as the issues of Hero I-League, Hero I-League clubs and the future roadmap of Indian Football including a unified League are important issues which need to be resolved in a time-bound manner, the AIFF Executive Committee requests the Asian Football Confederation to send a high-level delegation led by Dato Windsor John, General Secretary, Asian Football Confederation at the earliest to discuss this issue with all stakeholders of Indian Football including our commercial partners FSDL to arrive at a fair solution.
In the meeting of the Hero I-League clubs along with the AIFF President, and the General Secretary, held in Delhi on July 3, 2019, some broad proposals were discussed, and a joint statement was issued by AIFF and the Hero I-League clubs.
These amicable discussions were to be presented to the AFC Executive Committee for further consideration. However, on July 8, 2019, the clubs via a letter released to the media have taken a contrary stand which is not in the spirit with which the AIFF President had met the clubs. As a result, we have, therefore, asked the AFC to find a possible solution. Furthermore, all future official communications from the AIFF are to be addressed by the media department, apart from the General Secretary, and the President himself.
AIFF PRESIDENT PRAFUL PATEL ANNOUNCES 2018-19 AIFF AWARDS
09.07.2019- AIFF PRESS RELEASE : All India Football Federation President Mr. Praful Patel announced iconic National team striker Sunil Chhetri as the AIFF Men’s Footballer of the Year 2018-19 at the AIFF Executive Committee Meeting in the Capital today. This is the 6th time Chhetri bagged the prestigious Award having earlier won it in 2007, 2011, 2013, 2014, and in 2017. Chhetri was voted the winner on basis of votes from all Hero I-League, and Hero Indian Super League club coaches.
2018-19 AIFF AWARDS AT A GLANCE
AIFF Men’s Footballer of the Year 2018-19 : Sunil Chhetri (He was voted the winner by all I-League, and ISL Club coaches).
AIFF Women’s Footballer of the Year 2018-19 : Ashalata Devi (from Manipur).
AIFF Men’s Emerging Footballer of the Year 2018-19 : Abdul Sahal (from Kerala -- He was voted the winner by all I-League, and ISL club coaches).
AIFF Emerging Women’s Footballer of the Year 2018-19 : Dangmei Grace (from Manipur).
AIFF Award for the Best Referee 2018-19 : R Venkatesh (from Tamil Nadu).
AIFF Award for the Best Assistant Referee 2018-19 : Joseph Tony (from Karnataka).
AIFF Award for the Best Grassroots Development Programme 2018-19 : Jammu & Kashmir Football Association.
“The fact that this was voted by the Hero I-League and Hero ISL Coaches makes it all the more special. I am grateful to my club members, coaches, fellow players, the National team staff, and the fans for their support, love, and affection,” Chhetri said, moments after declared the winner. On being reminded about winning the Award for the 6th time, he added: “I never play for Awards. But yeah, it feels nice when your hard work gets recognized. This is an added motivation to do better.”
Apart from Chhetri, the others who have won the Award multiple times include IM Vijayan (thrice), and Bhaichung Bhutia, and Joe Paul Ancheri (twice each). Meanwhile, Abdul Sahal was declared the AIFF Men’s Emerging Footballer of the Year 2018-19. Sahal who was dubbed as the “next big thing in Indian Football” by Chhetri some days back, was also voted the winner by all Hero I-League, and Hero ISL club coaches.
Among the women, Ashalata Devi was declared the AIFF Women’s Footballer of the Year 2018-19, while Dangmei Grace won the AIFF Emerging Women’s Footballer of the Year 2018-19. The AIFF President met, and congratulated both of them. “Congratulations to you both,” he stated. “You deserve the Award. You have made us proud. I wish you best wishes for your future endeavours,” Mr. Patel added during his meeting with the Indian Senior Women’s National team in the Capital.
The AIFF Award for the Best Referee 2018-19 was won by R Venkatesh (from Tamil Nadu), while Joseph Tony was declared the winner of the AIFF Award for the Best Assistant Referee 2018-19. The 2018-19 AIFF Award for the Best Grassroots Development Programme went to the Jammu & Kashmir Football Association. “I congratulate all the winners.,” Mr. Patel said. “They serve as an inspiration for all budding aspirants, and their colleagues. We are extremely proud of all of them.”
AIFF PRESIDENT met representatives of 10 Hero I-League clubs
03.07.2019 - AIFF PRESS RELEASE : Mr. Praful Patel, President, All India Football Federation, along with Mr. Kushal Das, General Secretary, AIFF, and Mr. Sunando Dhar, CEO, I-League on Wednesday (July 3, 2019) met representatives of 10 Hero I-League clubs to discuss the future of the Leagues, and broad framework of football in India.
AIFF as a custodian of Indian Football is concerned about the well-being, and the future of Indian Football including Hero I-League clubs whose contribution to Indian Football has been long-standing.
Indian Football’s backbone has been the developmental and promotional activities, including the youth programmes conducted by the Hero I-League clubs. With the advent of the Hero Indian Super League, which is also a league recognised by the Asian Football Confederation, it is imperative to find a viable, and sustainable mechanism to mitigate the concerns about the future of the Hero I-League, and its clubs.
AIFF and the Hero I-League Clubs have agreed and will work together to find a solution to all issues including the calendar, scheduling, broadcasting, and the continuation of the Hero I-League for a defined period, till the roadmap is ascertained in a time-bound manner in consultation with FSDL, and the AFC.
A lot of other meaningful issues were also simultaneously discussed, and it is hoped that all issues regarding the future of the Hero I-League vis-à-vis the Hero Indian Super League will be resolved shortly.
The Hero I-League clubs were happy to have engaged in the discussions which will pave the way for a resolution of the pending issues, and thanked the AIFF President for his understanding, and patient hearing.
ISL Champions Bengaluru FC to start Soccer Schools centers in Pune
01.07.2019 - BFC PRESS RELEASE : Indian Super League champions Bengaluru FC announced on Monday, that its expansion of BFC Soccer Schools had reached Pune, in Maharashtra, where it will soon be functional in two new centers. The new program, which will be in association with Sports Excel, will be for boys and girls between eight and fourteen years of age at Vidya Bhavan School in Model Colony, Shivajinagar, and for girls between eight and sixteen years of age at The Bishop’s Co-Education School, Undri.
“We are delighted to tie up with Sports Excel because they are a brand that understands football coaching and professionalism. We saw a good turnout in Gujarat for our first BFC Soccer Schools center outside Karnataka, and Pune was always on our radar. We want to give children in the golden age, the U8s, U10s and U12s, the opportunity to play football in a professional environment and a clear pathway to the Bengaluru FC youth academy. We’re looking to reach out to more schools within Pune, and hopefully also to other states in the future,” said club CEO, Mandar Tamhane.
With 14 functional centres in Bengaluru and their recent tie-up with Sporthood taking their reach to over 35 centres in the city over the coming weeks, BFC Soccer Schools had, earlier in June, announced their first venue outside Karnataka, with the Adani Shantigram center in Gujarat.
"This association with Bengaluru FC Soccer Schools is a big moment for us because as a club, this is one of the most successful ones in India and one that has, in its short history, made a mark on Indian football. Our holistic approach teaches them how to become better individuals, and I believe that the coaches and curriculum from Bengaluru FC will be of much benefit to these children. Hopefully, some of them can get selected into the club’s academy in the future," said Mr. Christanand Vase, Director of Sports Excel.
The program will be monitored, and the progress of the players will be tracked by the Technical Head of BFC Soccer Schools and Grassroots Development, Mr. John Kenneth Raj, who will also be providing the technical curriculum and structure, and will also be tasked with educating the coaches of Sports Excel.
KOLHAPUR Gadhinglaj United Football Association observed 4th “Football Proud” Award
30.06.2019 - GUFA PRESS RELEASE : MAHARASHTRA BASED KOLHAPUR Gadhinglaj United Football Association successfully observed thier 4th All India level “Football Proud” Award ceremony on 29th June In his national level annual Award gave honour to the well-known football personalities, like Coach, organization, individuals etc who are associated with the beefit of football development in india by their own credibalities.
Gadhinglaj United Football Association secretary deepak Kuppavar told us that in a grand function Football Proud Award went to Jaipur- Rajasthan based reknowned AIFF match Commissioner Rabin Xavier - who is working from last 15 year to develop Rajashthan football. He is also Director & CEO of Jaipur Football Club Private Limited. Mr. Robin Xavier, who was facilitated through Kolhapur's Member of Parliament Prof. Sanjay Mandlik.
EX Cabinet Minister & MLA Hasan Mushrif, FIFA Coach Instructor Mariyano Dies, KSA Football Secretary Prof. Amar Sasane graced the grand occasion as the chief guest. Deepak also told that Last three Years their Organisatiob gave the honour of " Football Proud" to Karnataka Government lifetime sports awardee Coach Dadapeer ( Bangalore), Ex International Coach Raman Vijayan ( Tamilnadu), AIFF executive member Deepak Sharma ( Himachal Pradesh)
In the ceremony the Life time Achievement Award went to Maharashtra's Pusad ( Dist. Yavatmal) Chetana Krida Mondal. Chetana Krida monal organised All India tournaments since 1971. The Organisation President Dada Aahale, Secretary A.D. Khan was facilitated by Amar Sasane.
The Rising player Award (U 19) went to Kolhapur's Kunal Chavan iwho was falicitated by MP Sanjay Mandlik. Gadhinglaj Uniteds Sourbh Patil (Santosh Trophy) & Prashant Salwade ( U 14 Maharashtra ) also facilitated. Other than GUFC Secratry & Coach Deepak Kuppanvar, GUFA Director Satish Patil, Vice President Arvind Bardeskar, Treasurer Mahadev Patil, Director Bhairu Salwade, Prashant Daddikar, Manish Kole were also present.
Copyright @kolkatafootball.com - 2018 : INDIAN FOOTBALL LIVE - www.kolkatafootball.com Designed by 365Bootstrap.com
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Lily Absinthe
Gowns & Corsetry
The Lily Absinthe Bridal- Made With Love
The “Lily” Gown
The “Alexandra” Gown…For Your Most Royal Of Days
Wedding Fashions Of The Late 19th Century
Wedding Dresses Of The 1870s
More Wedding Fashions Of The 1880s
Portfolio of Lily Absinthe Gowns
Gowns & Dresses For All Occasions
Evening & Ball Gowns
The Old West
Adam’s Atelier – Where History Meets Fashion
The New Woman of the 1890s
The Bustle Dress – A Brief Overview, Part 1
Fashion Designers & The Rise of the Fashion Industry
Some Fashion Theory From Maison Worth
John Redfern/Redfern & Sons/Redfern Ltd.
The Philosophy Of Paul Poiret – Principles Of Correct Dress
Gustave Beer
Fashion Terminology
Recommended References
At The Movies With Lily Absinthe
Nadezhda Lamanova, Part 1
August 22, 2020 August 21, 2020 / Adam Lid
As with many of our posts, the subject of this one started with one topic but ended with a completely different topic. Initially, we came across some pictures of a ballgown that had been designed in the early 1900s for the Empress Alexandra Feodorovna, consort of the Nicholas II, the last Emperor of Russia. Then, we noted that the designer was a one Nadezhda Lamanova. What was interesting here was that it was both a designer that was unknown to us and even more striking was that she was female. While almost all of the labor force making Haute Couture dresses were female, it was rare that the designer was female, at least before the 1920s.
Nadezhda Lamanova was born on December 14, 1861 in Nizhni Novgorod, Russia and died in Moscow on October 15, 1941 at the age of 79. Due to her parents’ death at an early age, in 1877 she underwent training as a seamstress at the Moscow School of Sewing. Two years later, she went to work for a fashion house. In 1885, she opened her own dressmaking shop in Moscow and successfully built up her business; until it had become the most popular dressmaking establishment in Moscow. At some point (the translation is unclear), she traveled to Paris and met up with Paul Poiret (hopefully we can find out more about this in the future). Eventually, her work came to the attention to the Imperial Court and she was designated as “Supplier of the Court of Her Imperial Majesty” with her designs being worn by the ladies of the Court and the Empress herself. Finally, starting around 1901, Lamanova also designed costumes for theatrical productions.1Unfortunately, there’s not a lot about her in English so we’ve gleaned some of the basic biographical details from a variety of sources.
Early portrait of Nadezhda Lamanova, date unknown.
Nadezhda Lamanova, portrait by Valentin Serov, 1911.
However, it’s after the Russian Revolution where Lamanova’s career became even more interesting. Arrested in 1919 by the Bolshevik Government (having been an officially designated designer for the Imperial Court could easily have been her death warrant), she was freed by the intervention of the writer Maxim Gorky after spending about 2 1/2 months in prison. Afterwards, she focused on designing theatrical costumes (presumably rehabilitating herself in the eyes of the Bolshevik regime in the process).
The Bolshevik Revolution- Big changes were coming to Russia…
By early 1920s, Lamanova had started designing clothing aimed at the masses, drawing upon traditional Russian dress and even some of her designs were incorporated in an official graphic “how-to” booklet called “Art in Everyday Life” in the form of simple clothing patterns. Below are two samples:
During the 1920s and 1930s, Lamonova’s designs were successfully displayed in various exhibitions outside of Russian and at the same time she continued to design costumes for both the theater and film. Below are just a few examples of her work (one can definitely get a Paul Poiret vibe looking at these):
Outfit by Nadezhda Lamanova inspired by traditional costumes of northern peoples, 1923; modeled by the actress Alexandra Hohlova.
Actress Alexandra Hohlova modelling another dress design by Lamanova, 1924.
Lilichka Brik (seated) with her sister Elsa Triolet in folk-inspired dresses by Lamanova, 1925.
Lamanova fashions from the 1920s.
So, what dress is it that got us travelling down this unusual path? Well, here is is, a ballgown that belonged to Empress Alexandra Feodorovna:
Nadezhda Lamanova, Ballgown, Early 1900s; State Hermitage Museum (ЭРТ-8619)
Close-up of Bodice
Close-Up of the Dress
This is a ballgown that was created in the early 1900s. Unfortunately, specific details (in English, at least) are scanty but based on the dress style, we are probably looking at the 1900-1906 time frame. The dress is constructed from white/ivory-colored silk satin underskirt combined with a white/ivory tulle decorated in sequins, beading and appliques using a floral design motif. As with any of these dresses, the hours of hand-labor put into the embroidery and attaching the sequins is simply mind-numbing.
This ballgown is stunning and it epitomizes the luxury of the Russian Court. At the same time, know some about the designer, it’s amazing that Nadezhda Lamanova was able to successfully reinvent herself at a time when anyone with an association to the Ancien Regime, no mater how remote, was suspect and oftentimes a one-way ticket to the firing squad. In the next installment, we will look at some more of Lamanova’s work prior to 1917.
Adam Lid, Adam's Atelier, Costume History, Designers, Dress Designs, Edwardian, Edwardian (1901 - 1910), Fashion History, Karin McKechnie-Lid, Lily Absinthe Gowns and Corsetry, Nadezhda Lamanova, Teens (1910 - 1919), Victorian (to 1901), Victorian Dress
1890s, 1900s, 1920s, Adam Lid, Adam's Atelier, Best In The West, Costume History, Dress Designs, Edwardian, Edwardian Dress, Edwardian Fashionista, Fashion Design, Fashion History, Hollywood Victorian, Karin K. McKechnie-Lid, Lily Absinthe Gowns and Corsetry, Nadezhda Lamanova, Teens, The Edwardian Designer, The Victorian Designer, Victorian, Victorian Dress, Victorian Fashionista
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Nadezhda Lamanova, Part 2 →
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Justice Kirby reflects on La Trobe Law School’s contribution to legal education
Posted on May 6, 2019 by La Trobe
Last year saw two visits to la Trobe Law School by The Honourable Michael Kirby AC CMG. On his first visit last year, Justice Kirby was joined by one of our Judges in Residence, the Honourable Geoffrey Eames AM QC, in our Moot Court. In an event entitled “Two Lives in the Law” the two judges took questions from our students about their experiences, and the professional values and qualities which should shape a career in law. Justice Kirby kindly sat down with us to reflect upon La Trobe Law’s contribution to Australian legal education and scholarship. His Honour’s kind comments about the achievements and traditions of our School underline its ongoing mission in serving the broader community.
Late last year, Justice Kirby returned to the Law School to deliver a lecture on the new punitivism, with a focus on the nature of media reporting of criminal justice issues. His Honour was joined by Professor Kris Gledhill from the Auckland University of Technology and Head of School Professor Patrick Keyzer who provided commentary on the themes identified by his Honour. Thanks also to our Deputy Head of School and Director of Criminology Professor Anne Wallace who chaired the event.
We thank His Honour for so generously sharing his time with our staff and students, who were inspired by his Honour’s example and reflections in these sessions.
La Trobe LawTech explores big data, privacy and the law
Awards celebrate La Trobe Law Students’ Excellence
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J. L. Chave Hermitage Blanc
2017 J. L. Chave Hermitage Blanc
Appellation: Rhone
Wine Advocate: 98+
James Suckling: 95-96
THIS IS NOT GOING TO GET ANY BETTER OR CHEAPER!! THE RARE BLANC IS IN A LEAGUE ALL ITS OWN!!...EXTREMELY RARE, LIMITED, AND ALLOCATED, BUY NOW!!
"In the end, I'm unable to definitely say that the 2017 Hermitage Blanc is better than the stupendous 2016. Of course, I sampled it just three days after it was bottled, so I've appended the + to my rating, as there's a possibility the wine may have been affected by that process. It's gently toasty but dominated at this stage by forward melon and pineapple fruit. Full-bodied and incredibly rich yet balanced, it unfolds in waves of flavor and texture, lingering for what seems like minutes on the finish. Hit it soon to enjoy its youthful opulence, or put it aside for 10-12 years.
Jean-Louis Chave seems increasingly confident at the helm of this legendary domaine. We spent a bit of time discussing the 2018 vintage, which he rates highly. "The wines are not really jammy. They're almost as ripe as 2003, but for some reason the grapes weren't raisiny," he said. "The vines never really stopped. In mid-August, we had 40 millimeters of rain—perfect timing. And at the end of August another little rain." Hermitage shines this year. "In Hermitage, you can push things to the limit and still be OK," Chave said. "Even when it's extreme, the grands terroirs are still the grands terroirs." Looking at recent vintages, Chave summarized the similarities as follows: 2015 he compares to 1990; 2016 to 2010; 2017 to 2000. As for 2018, said Chave, "It wouldn't be right to compare 2018 and 2003. The ripeness is extreme, but at the end, they're very different wines." Hermitage aside, Chave has spent much of his time in recent years working on his vineyards in Saint Joseph. He said he thinks of Saint Joseph as a wine for bistros rather than haute cuisine, but Chave's Saint Joseph's have quickly progressed beyond that in terms of quality (and, unfortunately, price)." (WA)
"Translucent yellow. An intensely perfumed bouquet evokes ripe pear, yellow plum, orange zest, smoky minerals and jasmine, along with a deeper suggestion of honey. Honeysuckle, energetic, sharply delineated citrus, orchard fruit flavors stain the palate and become weightier with aeration. The mineral note expands as the wine opens up and drives an impressively long, chewy finish that features lingering floral, brioche and saffron notes." (VM)
"Tasted as a set of components. Attractive expressive fruits in the peach and dried-pear zone. Lemon citrus with savory aromas of spiced biscuits and river stones too. Powerful stone-fruit flavors, building to ripe dark peaches. The texture runs from chalky to pithy and right through to a more compressed stony finish. Super long, complete and focused. White Hermitage is all about texture and this is a lesson in exactly that. Barrel sample." (JS)
"Cut from the same cloth, the 2017 Hermitage Blanc is stunning stuff, and Chave lovers should unquestionably have bottles of this in the cellar. Bottled in August of this year, its medium gold hue is followed by a mammoth bouquet of quince, flower oil, buttered almonds, and brioche. Every bit as good on the palate, it’s full-bodied, has a stacked mid-palate, flawless balance, and incredible minerality as well as length on the finish. It’s insanely good today, and while this cuvée can shut down, I wonder if this ever will. My money is on this drinking fabulously well for 25+ years. Life is too short not to drink as much Chave Hermitage Blanc as possible!
This bastion of traditionally made wines lies in the tiny village of Mauves, just south of Hermitage, and few wine drinking experiences compare to an evening spent in Jean-Louis Chave’s cellar tasting through the different terroirs of Hermitage and Saint Joseph. It has unquestionably been one of the highlights of my year going on a decade now. Founded in 1481 and with over 500 years of winemaking history, Domaine Chave has seen an incredible succession of talented vignerons, with Gérard Chave, who was born in 1935, managing the estate brilliantly up through 1990. Gérard slowly began handing the reins of the estate over to his son, Jean-Louis (born in 1968), in the late 1980s and early 1990s. While Gérard is still involved, the weight of this historic estate falls firm on the shoulder of the more than capable Jean-Louis Chave today. While this family has always stayed firmly planted in tradition, they’re far from dogmatic, nor do they rest on their laurels or reputation. They’ve recently completed work on a new cellar (just across the street from their existing cellar and connected via a tunnel) in 2014, and have resurrected new vineyard sites in Saint Joseph. While the new cellar includes a state-of-the-art lab, Jean-Louis has always been quick to point out, “You don’t need a lab to make great wine.” Along with the help of Jean-Louis’ wife, Erin Cannon-Chave, they also continued to grow their négoçiant label, Chave Selection, which offers fabulous bang-for-the-buck and includes both Northern and Southern Rhônes. While this estate is rightly known for its Hermitage, Jean-Louis has invested the past ten years or more in resurrecting older vineyards in Saint Joseph, with some sites just now coming online. They currently release an Estate Saint Joseph, which comes from a mix of their estate terroirs, and a Saint Joseph Le Clos, which is a single vineyard located just south of Mauves. The Estate Saint Joseph is a classic example of the appellation and offers ample dark, blacker fruits, minerality, and peppery characteristics as well as a touch of austerity and building structure. The Saint Joseph Le Clos comes from a warmer, earlier terroir and is always more refined, elegant, and seamless, with redder fruits and a perfumed, spice-driven style. Both are brilliant, singular wines, and I’ve no doubt the best is still to come here. Looking at Chave’s Hermitage releases, all the grapes are destemmed (I believe some stems were included before the 1980s) and the individual terroirs are vinified separately. Starting in 1990 and 1991, the Chaves replaced their old concrete fermenters with stainless steel tanks. They continue today to use their three larger oak uprights for vinification as well, due to the ability to perform punch-downs. Aging occurs in small French oak barrels with the amount of new oak falling in the 20-30% range. The wines are then blended in tank and bottled without being filtered. If needed, the wines can see a light egg-white fining before bottling. In addition to the classic Hermitage, Chave can release a small production Cuvée Cathelin, which generally comes all from the Les Bessards lieu-dit and sees slightly more time in oak. Only made in the great vintages (1990, 1991, 1995, 1998, 2000, 2003, 2009, 2010, and 2015), it’s almost impossible to find bottles of this elixir, but it’s usually a more opulent, powerful wine compared to the classically styled Hermitage release. Regardless of the wine, the style here is beautifully transparent, and the wines always show the vintage characteristics clearly (which Jean-Louis likes to describe as either a “Granite” year or a “Sun” year). While the wines have the balance and purity to dish out plenty of pleasure in their youth, they age beautifully, with Jean-Louis recommending at least 15 years of cellaring for most vintages of his Hermitage. With more and more of Hermitage going to giant corporations these days, it’s inspiring to see this small, family-owned estate still sitting at the top of the hierarchy, both in Hermitage and the entire world of wine. Jean-Louis is still young (and has a young son who takes after him, and a daredevil daughter who takes after Erin), so the future is very bright at this estate! " (JD)
2010 Remelluri Rioja La Granja Remelluri Gran Reserva
2018 Ridge Zinfandel Lytton Springs
2018 Charles Smith Substance Cs Cabernet Sauvignon
N.V. Arlaux Grande Cuvee Brut 1er Cru
2018 Tenuta San Guido Guidalberto
2018 San Simeon Cabernet Sauvignon Estate Reserve
N.V. Daimon Sake Road to Osaka Junmai Nigori 720 ml
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Sunday Brunching
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Category: Eat and Family Dinners
Address: Jalan Pura Batu Mejan, Canggu
Echo Beach House
Place Category: Eat and Family DinnersPlace Tags: Cafe culture, Family Dinners, Sunday Brunching, and Sweet Treats & Ice Creams
Famous sunset BBQ’s…
It’s noisy, it’s busy, in fact it can be absolutely packed at times, but it’s fun, relaxed, casual and provides a pretty damn perfect position to settle in for the evening and watch a beautiful Bali sunset.
This popular beach front spot with a the cool surfie vibe, attracts locals and tourists alike, many with kids who can be seen running about, scooting around, and munching on burgers, fish and chips, ice-cream and other delights from the kids menu. And of course highchairs are also available for the littlest ones.
The legendary grilled fish BBQ has become an institution, and certainly serves up a tasty and affordable dinner – perhaps a piece of grilled fresh Mahi Mahi and some prawns along with BBQ’ed corn on the cob, coleslaw, salad and bread.
This place has got the lot – prime sunset viewing position, good vibes and good food. All making for a great spot for a family dinner, some good times and good memories.
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Chef Eddie Garza Talks About How Being Vegan Saved His Life
Jessica Rodriguez
Eddie Garza is on his second act in life. The vegan chef went from being a professional musician and teacher to a celebrity chef and public speaker who’s using food to change the world. He’s gone from teaching scales to teaching people how to eat food that’s good for them and the world they live in.
The 42 year-old Mexican American has taken his culinary secrets and re-imagined Mexican food as vegan fare. In his new book, Salud! Mexican Vegan Cookbook, Garza shares 150 plant-powered recipes including favorites like flautas and burritos as well as fideos and moyetes (open-faced sandwiches).
His food is so good that he has been a private chef for Latino celebrities including Marco Antonio Regil, Ximena Córdoba, and Catalina Robayo. Garza has shared his ideas about food in schools and large conferences like South by Southwest in Austin and ExpoSer in Mexico City.
We spoke to Garza about life before and after going vegan, power plants and why Mexican food is vegan food hiding in plain sight.
‘LLERO: Tell us about how and why you went vegan?
Chef Garza: I went vegan when I was 21 years old. I weighed 310 lbs and I’m 5’7”. Morbidly obesity at that point. I had constant sprained ankles because of my obesity and couldn’t walk. [I was a musician and teacher at the time] and one year on the first day of classes [a new teacher] said “Dude you’re fat!” She said it so bluntly like she was in shock. I turned beet red and started sweating. She said ‘Join me this weekend. I’m going to this meeting to learn how to lose weight.” So I did. We were in AA for food. I learned about eating and health and together we made this big lifestyle change.
I also learned about the environmental impact of agriculture. Diet is the most important and impactful way to help. At this time I started meeting more people involved in this work for ethical reasons and saw how animals were treated. It all came full circle. It started with health, then empathy towards all animals and now knowing I’m being a champion for the environment.
‘LL: For those who don’t know tell us what being vegan is.
CG: To be vegan, at least in food world, means not consuming animal products: meat, dairy, eggs, anything that comes from an animal including honey from bees. My kitchen is completely animal free.
‘LL: How and why did you switch careers?
CG: I’ve been cooking as long as I can remember. It was one of the first things I knew I wanted to do. When I was 7 years old, my mom was sick so I made her breakfast in bed, French crepes. I knew at that point, ‘This is my calling.’ My lifestyle change prompted my career change. I went to study with a chef in Dallas at the Spiral Diner. The only established vegan restaurant where I was living. I went back to myself as a chef. Applied all the tricks I learned to my Mexican kitchen. That’s when I really found my identity. Less than a year in, I branched out on my own. I started out as a private chef and it was really word of mouth from there.
eddie garzaHealthMexicanmexican foodvegan
Besides putting pen to paper for ‘LLERO Jessica is a co-founder. She is a seasoned writer, editor and journalist who has successfully peddled her words across media platforms from Urban Latino, Latina and Cosmo Latina, since picking up her professional pen in 1999.
The TriLatino Club is Breaking Barriers & Saving Lives
Flaco Coquito
Ana Mantica
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<See a full text list of this group of Prints>
<Navigate Print thumbnails one-by-one>
AN AFFECTING SCENE IN KENTUCKY.
Complete Explanation:
A racist attack on Democratic vice-presidential candidate Richard M. Johnson. The Kentucky Congressman's nomination, in May 1835, as Van Buren's running-mate for the 1836 election raised eyebrows even among party faithful, because of Johnson's common-law marriage to a mulatto woman, Julia Chinn, by whom he fathered two daughters. The artist ridicules Johnson's domestic situation, and the Democrats' constituency as well.
Seated in a chair with his hand over his face, a visibly distraught Johnson lets a copy of James Watson Webb's "New York Courier and Enquirer" fall to the floor and moans, "When I read the scurrilous attacks in the Newspapers on the Mother of my Children, pardon me, my friends if I give way to feelings!!! My dear Girls, bring me your Mother's picture, that I may show it to my friends here." On the right are his two daughters, Adaline and Imogene, wearing elegant evening dresses. One presents a painting of a black woman wearing a turban, and says, "Here it is Pa, but don't take on so." The second daughter says, "Poor dear Pa, how much he is affected." A man behind them exclaims, "Pickle! Pop!! and Ginger!!! Can the slayer of Tecumseh be thus overcome like a summer cloud! fire and furies. oh!" Johnson is reported to have slain the Indian chief Tecumseh.
Flanking Johnson are a gaunt abolitionist (right) and a black man. The abolitionist holds a copy of the "Emancipator," a Hartford, Connecticut newspaper, and says, "Be comforted Richard; all of us abolitionists will support thee." The black man pledges, "...de honor of a Gentlemen dat all de Gentlemen of Colour will support you."
On the far left is a stout postmaster who says, "Your Excellency, I am sure all of us Postmasters and deputies will stick to you; if you promise to keep us in office."
The print seems to date from early in the campaign of 1836. Johnson's wife Julia Chinn died in 1833. Adaline, one of the two daughters pictured, died in February 1836. Although Weitenkampf dates the print at 1840, when Johnson was again Van Buren's running-mate, the presence of both daughters and the drawing style are persuasive evidence for an 1836 date.
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Country Stars With April Birthdays
Rick Diamond / Larry Busacca / Kevin Winter, Getty Images
The fourth month of the year, April includes many exciting occasions and observances, including the Boston Marathon, Record Store Day, Earth Day and April Fools' Day, along with everyone's least favorite day: Tax Day. But April also is the birthday month of a bunch of country stars.
Sharing a birthday month with these fun (and not-so-fun) events are Loretta Lynn, who will celebrate her 88th birthday; Willie Nelson, whose 87th birthday is approaching; Glen Campbell; Emmylou Harris and more. One of the youngest birthday girls during the month of April is Lady Antebellum frontwoman Hillary Scott, who will be turning the ripe old age of ... 34.
With spring blooms, budding trees and longer days, April is a great month to be born. Find out who celebrates their birthday in April -- and if you have an April birthday, perhaps you share it with one of country music's great artists. Happy birthday to them -- and to you!
NEXT: Country Stars With March Birthdays
Source: Country Stars With April Birthdays
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Fellow Executives and Staff-Members of the Lopez Group, Honored Guests, Ladies and Gentlemen:
The theme of our 11th HR Summit is “Living The Lopez Legacy”. This morning, I would like to share with you some of my thoughts on the subject of legacy.
Dictionaries define the word “legacy” to mean something transmitted, handed down, received, or inherited from an ancestor or predecessor, or from the past.
In this context, I suppose it would be appropriate to say that the Lopez businesses are the legacy that we have inherited from our founders, my father, Eugenio Lopez, Sr. and his brother, Fernando. Some of our principal companies remain the very companies that they either established or acquired, for example, ABS-CBN and First Holdings. And yet, through the years, the composition of the Lopez businesses has also dramatically changed. Although we still own a small part of Meralco, we have ceased to hold a controlling interest where, once, we owned 100% and where once, Meralco was the centerpiece of our business. On the other hand, we now own controlling interests in such major businesses of more recent vintage as First Gen, EDC and Rockwell Land. Is it possible that at some point in the future, the businesses will have changedso much that they will cease to be recognizable as a legacy of their founders?
There are other ways by which we seek to more intimately carry on my father’s legacy and keep it alive. The principles and values by which we run our businesses and live our lives, which we have recently formally recognized in the Lopez Credo as The Lopez Values. The family and corporate biographies that we have caused to be written. We have, right at our doorstep, at the ground floor of our corporate headquarters, the physical legacy of my father and our family. As a nationalist, imbued with love of country and its history, my father built, collected and expanded until his very last days, the Lopez Museum and Library, which is now under the Eugenio Lopez Foundation.
What I would like to ask each and every one of you here, the HR officers of our group, is to help spread this spirit and value of nationalism of the Lopez family, by encouraging each and every one of our 12,000 employees, contractuals included, to visit and appreciate this treasure trove right in our Benpres building. I would love to see monthly group tours of Lopez employees from all of our companies nationwide, and even those who are based abroad, whenever they are here. I hope you will make this tour part of every employee’s, new and old, orientation as a Lopez citizen. We are one of the very few business conglomerates in the Philippines, and indeed, in Asia, with a strong arts, culture and historical orientation and collection. Let our employees experience and enjoy, first hand, our value of nationalism and the pride we take in being Filipino.
Incidentally, the original buildings that make up the Asian Institute of Management also carry the name of the Eugenio Lopez Foundation as their donor.
Ultimately, however, nothing that is merely physical can ensure a legacy’s survival, and that is what I find deficient in the definitions of the word “legacy”, that they somehow imply a limited shelf life. Think about it. A legacy is only a legacy for as long as somebody remembers what has been handed down. We know that time erodes most memories, so that within one or two generations, memories can be, and are often, forgotten. Even when memories are enshrined in history books or biographies, they tend to be consigned to shelves in libraries or archives where, after a while, they mainly collect dust. Worse, as we have found in regard to the history of our country, the memories are revised by those who write about them or who want to change them. Thus do memories, or legacies, disappear in the dustbin of history.
But there is one way by which a legacy can survive the test of time. This is when the inheritors breathe life into the legacy, so that they themselves become a living legacy, or rather, the living legacy.
Within the Lopez companies, we have, as I noted previously, sought to preserve the legacy that we have inherited from our founder in a number of different ways. I believe that we have largely been successful in preserving the legacy of my father, to the point that we now refer to it as “The Lopez Way”. But we could not have done it had we not conducted our businesses and lived our lives in accordance with the principles and tenets that he passed down to us. At times, this has been very difficult, because we have been forced to put our businesses at risk on matters of principle, just as my father had to put his businesses at risk on matters of principle.
The theme of this conference, “Living The Lopez Legacy”, exactly hits the mark in that the only way to preserve a legacy is to live it and to live it faithfully. By doing so, we ourselves become the living legacy. And, as I have mentioned often in the past, it is my dream that our businesses, our companies, will survive the next four hundred years, and beyond, as will the Lopez legacy.
I congratulate our HR Council for once again organizing our annual HR Summit and for putting together a most interesting program of discussions. Thank you and I hope all of you make the most of what we have in store for you today.
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2019 20IS
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Lopez Holdings Corporation
16/F North Tower, Rockwell Business Center Sheridan, Sheridan St. corner United St., 1550 Bgy. Highway Hills, Mandaluyong City, Philippines
Trunkline: (632) 8878 0000
Fax: (632) 8878 0000 ext 2009
© Lopez Holdings Corporation 2015. All rights reserved
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Health Law Daily Summary judgment granted against pro se complaint due to EMTALA compliance
Summary judgment granted against pro se complaint due to EMTALA compliance
By Gregory Kane, J.D., M.B.A.
Summary judgment was granted to a hospital defending an (EMTALA complaint against an emergency room patient who did not have an emergency medical condition and was stabilized before being discharged.
A California hospital was granted summary judgment in an Emergency Medical Treatment and Active Labor Act (EMTALA) complaint from a former emergency room patient because that patient had not had an emergency medical condition and the hospital not only stabilized her condition but took into account additional risks and factors including mental health prior to discharging her (Crawford v. Kaiser Foundation Hospitals, July 21, 2020, Beeler, L.).
Background. On March 24, the patient went to Kaiser’s emergency department complaining of difficulty breathing. The treating physician examined her and ordered extensive testing noting that her allergy to Albuterol and prior splenectomy posed a risk of bacterial infection. She was diagnosed with community-acquired pneumonia and asthma. She was prescribed certain medications and it was noted that her symptoms were exacerbated by anxiety, but the doctor concluded she was not suffering from an emergency condition and she was discharged. At that time the patient’s vital signs were unremarkable, she was ambulatory and her condition had improved. She had also asked to go home.
The patient returned to the emergency room on March 25, complaining of shortness of breath. She had not taken some of the prescribed medication. Within half an hour of her arrival she was cleared as stable and within medical probability that she would not deteriorate is she were transferred or discharged. Due to the short time elapse between visits, however, the treating physician referred the patient for an inpatient consultation with a Kaiser hospitalist who made the clinical decision to monitor the patient overnight. The patient received the same treatment she would have received had she been admitted as an inpatient. Around midnight that night, the patient was examined and based on the record and examinations, a hospital physician determined that the patient did not show emergency conditions or needed immediate medical attention. The patient had an in-person consultation with a hospitalist the next morning and based on her history, imaging studies, test results and current vital signs, the hospitalist diagnosed the patient with community-acquired pneumonia and asthma. It was determined that the pneumonia was already improving with her symptoms exacerbated by anxiety and asthma. It was also determined that her condition was mild enough to treat with home care and follow-up visits and she was discharged. A social-worker consultation was also ordered to address the patients complaints about her care which related to her frustrations with the insurance and healthcare system Medi-Cal, which the patient described as racist and fraudulent.
Several hours after her discharge, the patient called for an ambulance and asked to be taken to a different hospital for shortness of breath. She was admitted as an inpatient for two nights and administered tests and given the same diagnosis and medications she had received at Kaiser.
The patient returned to the Kaiser emergency room on March 30 complaining of shortness of breath, but would not allow a nurse to draw blood, had not filled her prescriptions, demonstrated no shortness of breath, was combative with the hospital personnel, and left after refusing to sign "Against Medical Advice" paperwork.
The patient filed a complaint against Kaiser for violation of EMTALA for failing to stabilize her before discharging her. Kaiser’s motion to dismiss for failure to state a claim was denied as the patient had plausibly pled her claim. Kaiser moved for summary judgment prior to the close of discovery. The patient was appointed pro bono counsel and granted the patient’s motion to postpone the due date for her opposition. The pro bono counsel withdrew due to conflict with the patient and the parties relationship during discovery was contentious. Kaiser renewed its summary judgment motion after discovery closed. The patient did not file on opposition but did move for an additional 90 days of extended discovery. As discovery was extensive, her motion was denied. The patient was twice referred to the court’s resources for litigants representing themselves and advices of the court’s standards for summary judgment but the patient did not file an opposition or statement of non-opposition.
Kaiser’s expert witness opined that the patient had been stable after Kaiser provided her with the evaluation and assessment and testing and treatment she received prior to her discharge. He believes that Kaiser appropriately screened and stabilized her pneumonia and that the patient’s outcome would have not been different or improved by a longer period of time at the hospital.
Summary judgment. EMTALA imposes (1) a duty to screen a patient for an emergency medical condition and, if found, (2) a duty to stabilize the patient before transferring or discharging the patient. The record showed that the patient did not have an emergency medical condition and, even had she had one, Kaiser stabilized her prior to discharge. Summary judgement was granted.
The case is No. 19-cv-01573-LB.
Attorneys: Muneerah Crawford, pro se. John Stewart Simonson (Hayes Scott Bonino Ellingson Guslani Simonson & Clause LLP) for Kaiser Foundation Hospitals.
Companies: Kaiser Foundation Hospitals
MainStory: TopStory CaseDecisions EMTALANews CaliforniaNews
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A lorry stands on the edge of the collapsed Morandi motorway bridge in the northwestern city of Genoa. Picture: Valery Hache/AFP
Face-to-face with death: Photo shows near-miss
by Staff writers and New York Post
AMONG the visions of destruction from the 'apocalyptic' bridge collapse in Italy, a lucky truckie has emerged as the poster image of the tragedy as he lingers mere metres away from the brink of death.
On Tuesday, 80 metres of the 50-year-old Morandi bridge in Genoa collapsed and sent vehicles plunging 45 metres into a heap of rubble, with 22 people pronounced dead so far.
But one picture of survival has stunned the world, showing a green delivery truck stopping along a rain-soaked stretch of what remained of the highway.
GENOA BRIDGE COLLAPSE: Eerie warning before dozens killed
The truck blocked on the Morandi highway bridge after a section of it collapsed. Picture: AP/Antonio Calanni
Ahead of the world's luckiest trucker - who remains unidentified - was an abyss of twisted metal and concrete left behind when the bustling motorway suddenly gave way during a violent rainstorm around 11.30am local time (7.30pm AEST).
Hundreds of firefighters and emergency rescue officials are racing against time to find survivors in the rubble.
Cars fell with tonnes of twisted steel and concrete debris into a nearby river, railroad tracks and an industrial zone below.
Unidentified fire brigade sources had earlier told Italy's ANSA news agency that as many as 35 people were killed.
Italy's leader Premier Giuseppe Conte travelled to the site of the disaster this morning saying "it is shocking to see the twisted metal and the bridge collapsed with victims who were extracted".
The truck driver came mere metres away from the edge. Picture: AP/Antonio Calanni
He also praised the hundreds of rescue workers still at the site, saying "they saved people who fell 45 metres and are now alive and in the hospital".
Photos and video footage of the incident have emerged, showing the devastating aftermath which has left the northern port city reeling, and the world stunned.
Witnesses have likened the scene of the horrific accident - the deadliest of its kind in Europe since 2001 - to an apocalypse.
The cause of the disaster was not immediately clear, although weather services in the Liguria region had issued a storm warning Tuesday morning.
WARNING IGNORED: Chilling prediction before bridge collapse
bridge collapse editors picks fatalities fatality genoa italy
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Confident Bluebirds face Centrals test
JARRED Lacey is used to having to build up the confidence of his raw Swifts teammates.
Fortunately the squad is full of predominantly young and subsequently resilient cricketers.
So Lacey has no concerns they can pick themselves up to challenge Central Districts at Mark Marsh Oval today, following a below par effort last Ipswich Logan Premier League start against Eastern Taipans.
"We're looking pretty good," captain Lacey said.
"The boys are not quietly confident, but they're confident of doing a better job than our last performance.
"We played like busteds the whole two days."
There were excuses.
"We were sent in on a damp pitch," he said.
"If we'd won the toss, it might have been different."
But the concern for Lacey is that his players weren't able to put it out of their minds and get on with the job.
"A lot of blokes got psyched out," Lacey said.
"They had balls popping up at their necks on a good length and thought the only way to score runs was to smash it to the boundaries.
"Then when we bowled we didn't apply ourselves.
"When you're bowled out for 109, you're pretty down on yourself.
"It's all about confidence."
But with young players, a new game means a fresh dose of confidence, taking the positives and forgetting the lows.
"Young blokes can bounce back," Lacey said.
"They don't dwell on it much.
"Look at Mitch Wood.
"He's coping and doing well.
"He batted at four against Taipans and made 40-odd. In the second innings, he got out cheaply.
"But in the nets the last couple of times since, he's looked so confident."
Lacey himself is doing his bit to keep up the confidence of his teammates and is confident he has the measure of Centrals' South Queensland representatives.
"I know how to bowl to Benny (O'Connell)," he said.
"I had him plum on five last time but they didn't give him out.
"We know the areas we've got to bowl. It's just about executing.
"With Rhys (O'Sullivan), you just have to play straight."
central districts ipswich logan premier league jarred lacey swifts bluebirds
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Temples: Sri Kalahasthi
Sri Kalahasthi
Sri Kalahasthi is an important temple dedicated to Lord Shiva. It is situated in Chittoor district of Andra Pradesh. The Sivalingam is said to be a ‘Vayu lingam’ representing one of the five elements, air, (vayu-air) and is one of the Panchabootha sthala of Lord Shiva. This temple is also called ‘Thakshina Kailash’ meaning the abode of Lord Shiva in the south. The river Swarnamuki running near this temple gives this place an added sacredness.
The temple is about 3 km from Kalahasthi railway station but the easiest way to travel to this temple is by road either from Chennai or Tirupathi. There are frequent bus services from both these towns.
The temple occupies an area of about 5 acres and the tall towers are visible from miles around. The presiding deity is called Sri Kalahatheeswarar and the consort is worshipped as Gnanaprasunambika. There is also a small shrine to Lord Vinayagar that is reached by descending steep steps through a narrow opening. As the deity is installed below ground level the deity is known as ‘Pathala Vinayagar’
There are many legends associated with this temple. A spider, an elephant and a snake were living in the vicinity of the temple. All three were devotees of Lord Shiva. The spider wove beautiful objects with its silk like web and offered them to the Lord in prayer, the elephant brought flowers and water and washed the idol and offered the flowers, while the snake brought precious stones from underground and adorned the idol with them.
The elephant seeing these precious stones adorning the Lord cleared them away and after washing the Lord decorated Him with flowers and leaves. From this ensued an affray between the elephant and the snake. The snake bit the elephant and the elephant trampled the snake. The spider got caught in the middle of this brawl and all three died. Because of the devotion with which each one of them had spent their days worshipping, the Lord made these three souls to merge in Him and took the name Sri-Kala-Hasthi which denotes the conjoining of the spider (Sri), the snake (Kala), and the elephant (Hasthi) thus becoming Sri Kalahatheeswarar.
The Story of Kannappa Nayanar
Kannappan was a hunter but an ardent devotee of Lord Shiva. He never failed to perform his daily worship. He brought water from the river in his mouth and ‘bathed’ the image of the Lord by emptying his mouth on the lingam. Then he would chew bits of meat to ascertain its suitability and offer it to his deity. He would only proffer the choicest pieces of meat. One day he saw a yellowish discharge from the left eye of the image. He in his deep devotion wanted to cure the defect in the eye of his Lord. So he gouged out his eye from its socket and put it on top of the eye of the idol. He then noticed the same discharge from the other eye. He then decided to offer his other eye too, to the Lord. He realised that he would not be able to see once he had pulled out his other eye. So he put his shoed leg to mark the spot where the other eye would go and was about to pull out his eye when the Lord appeared and stopped him from self mutilation. The Lord pleased with his devotion granted him eternal bliss.
The goddess in this temple is worshipped as Gnanaprasunambika. This name was given to her for receiving the ‘Panchaksara manthra’ from the Lord himself. Before receiving this hallowed and potent ‘manthra’ she had to undertake severe penance and meditation.She arrived in Kalahasthi and started Her penance. Pleased with Her penance Lord Shiva imparted to Her the supreme knowledge and the ‘Panchaksara manthra’. Goddess Parvathy who was in the mortal form then attained her original form and stayed in Sri Kalahasthi as Gnanaprasunambika .
Opening Hours and Festivals
The temple opens its doors in the morning at 6 am and closes at 9 pm. The major festival takes place in February/March spread over 13 days. The other major festivals take place during December/January and during ‘Navarathry’ in September/October
Hindu Temples [English]mailerindiaComments off
Ramalinga Swamigal Biography
Temples: Sri Rangam
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Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature
G.R. Menon, S. Nair, R.M. Rao, M. Abraham, H.V. Easwer, K. Krishnakumar
Department of Neurosurgery, Kasturba Medical College, Manipal
Background: Rebleeding is an important cause for mortality following aneurysmal subarachnoid hemorrhage. Early intervention is believed to reduce the risk of rebleeding. However, in developing countries such as India, early intervention is often difficult due to various reasons. The knowledge about the risks and predictors for rebleeding is essential to prioritize the management policy. Aims: To describe the frequency and impact of rebleeding in the modern era of aneurysm care, to study the clinical profile of patients with rebleed and to review the controversial aspects on aneurysmal rebleed. Materials and Methods: This observational study is based on the retrospective analysis of the case records of all patients admitted with aneurysmal subarachnoid hemorrhage (SAH) since January 1999 in our institute. Twenty patients rebled after admission before surgical clipping, and these patients formed our study group. The findings were compared with all the major series on rebleeding published in literature. Results: Since January 1999, 952 patients underwent treatment for aneurysmal subarachnoid hemorrhage in our institute. Twenty patients rebled while awaiting surgery following the admission with an incidence of 2.14%. The study group included nine males and eleven females. The age of the patients ranged from 31 to 69 years, but the majority were in the sixth decade. Mean bleed to admission days was 7.9 days (range: 1-27 days), the mean admission to rebleed was 1.42 days (Range: 0-4) and the mean first bleed to rebleed was 9.26 days. The history of loss of consciousness at the time of bleeding was observed in 16 patients. Four patients bled before an angiogram could be performed. Two patients had giant aneurysms, while the rest had small aneurysms; two patients had multiple aneurysms. Angiographic spasm was observed in eight patients. In three patients, rebleeding was precipitated by angiogram. Twelve patients rebled while taking rest or in sleep, while one person rebled while defecating. Nine patients were taken up for emergency exploration immediately after rebleeding. From these, six patients died and three survived, but were severely disabled. The remaining eleven patients who were conservatively treated expired after varying periods of intensive care. Conclusions: Our incidence of rebleeding (2.14%) is considerably less than most of the other reported series, probably related to the delayed referral pattern. Probable predisposing factors for rebleed include old age, female sex and an anterior communicating artery location. Known risk factors such as hypertension, poor neurological grade on admission, stressful activity and aneurysm morphology do not appear to be significant in our study. Outcome is extremely poor following the rebleeds, either in immediate surgery or conservative treatment.
Annals of Indian Academy of Neurology
10.4103/0972-2327.37817
https://www.scopus.com/inward/record.uri?eid=2-s2.0-38349032545&doi=10.4103%2f0972-2327.37817&partnerID=40&md5=20bb468163e63ac33a9fe0d70a07e6eb
Fingerprint Dive into the research topics of 'Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature'. Together they form a unique fingerprint.
Aneurysm Medicine & Life Sciences
Subarachnoid Hemorrhage Medicine & Life Sciences
Angiography Medicine & Life Sciences
Bleeding Time Medicine & Life Sciences
Unconsciousness Medicine & Life Sciences
Spasm Medicine & Life Sciences
Menon, G. R., Nair, S., Rao, R. M., Abraham, M., Easwer, H. V., & Krishnakumar, K. (2007). Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature. Annals of Indian Academy of Neurology, 10(4), 247-251. https://doi.org/10.4103/0972-2327.37817
Menon, G.R. ; Nair, S. ; Rao, R.M. ; Abraham, M. ; Easwer, H.V. ; Krishnakumar, K. / Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature. In: Annals of Indian Academy of Neurology. 2007 ; Vol. 10, No. 4. pp. 247-251.
@article{8dcec873c5d349459a4030d3a074ae36,
title = "Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature",
abstract = "Background: Rebleeding is an important cause for mortality following aneurysmal subarachnoid hemorrhage. Early intervention is believed to reduce the risk of rebleeding. However, in developing countries such as India, early intervention is often difficult due to various reasons. The knowledge about the risks and predictors for rebleeding is essential to prioritize the management policy. Aims: To describe the frequency and impact of rebleeding in the modern era of aneurysm care, to study the clinical profile of patients with rebleed and to review the controversial aspects on aneurysmal rebleed. Materials and Methods: This observational study is based on the retrospective analysis of the case records of all patients admitted with aneurysmal subarachnoid hemorrhage (SAH) since January 1999 in our institute. Twenty patients rebled after admission before surgical clipping, and these patients formed our study group. The findings were compared with all the major series on rebleeding published in literature. Results: Since January 1999, 952 patients underwent treatment for aneurysmal subarachnoid hemorrhage in our institute. Twenty patients rebled while awaiting surgery following the admission with an incidence of 2.14%. The study group included nine males and eleven females. The age of the patients ranged from 31 to 69 years, but the majority were in the sixth decade. Mean bleed to admission days was 7.9 days (range: 1-27 days), the mean admission to rebleed was 1.42 days (Range: 0-4) and the mean first bleed to rebleed was 9.26 days. The history of loss of consciousness at the time of bleeding was observed in 16 patients. Four patients bled before an angiogram could be performed. Two patients had giant aneurysms, while the rest had small aneurysms; two patients had multiple aneurysms. Angiographic spasm was observed in eight patients. In three patients, rebleeding was precipitated by angiogram. Twelve patients rebled while taking rest or in sleep, while one person rebled while defecating. Nine patients were taken up for emergency exploration immediately after rebleeding. From these, six patients died and three survived, but were severely disabled. The remaining eleven patients who were conservatively treated expired after varying periods of intensive care. Conclusions: Our incidence of rebleeding (2.14%) is considerably less than most of the other reported series, probably related to the delayed referral pattern. Probable predisposing factors for rebleed include old age, female sex and an anterior communicating artery location. Known risk factors such as hypertension, poor neurological grade on admission, stressful activity and aneurysm morphology do not appear to be significant in our study. Outcome is extremely poor following the rebleeds, either in immediate surgery or conservative treatment.",
author = "G.R. Menon and S. Nair and R.M. Rao and M. Abraham and H.V. Easwer and K. Krishnakumar",
note = "cited By 1",
journal = "Annals of Indian Academy of Neurology",
Menon, GR, Nair, S, Rao, RM, Abraham, M, Easwer, HV & Krishnakumar, K 2007, 'Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature', Annals of Indian Academy of Neurology, vol. 10, no. 4, pp. 247-251. https://doi.org/10.4103/0972-2327.37817
Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature. / Menon, G.R.; Nair, S.; Rao, R.M.; Abraham, M.; Easwer, H.V.; Krishnakumar, K.
In: Annals of Indian Academy of Neurology, Vol. 10, No. 4, 2007, p. 247-251.
T1 - Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature
AU - Menon, G.R.
AU - Nair, S.
AU - Rao, R.M.
AU - Abraham, M.
AU - Easwer, H.V.
AU - Krishnakumar, K.
N1 - cited By 1
N2 - Background: Rebleeding is an important cause for mortality following aneurysmal subarachnoid hemorrhage. Early intervention is believed to reduce the risk of rebleeding. However, in developing countries such as India, early intervention is often difficult due to various reasons. The knowledge about the risks and predictors for rebleeding is essential to prioritize the management policy. Aims: To describe the frequency and impact of rebleeding in the modern era of aneurysm care, to study the clinical profile of patients with rebleed and to review the controversial aspects on aneurysmal rebleed. Materials and Methods: This observational study is based on the retrospective analysis of the case records of all patients admitted with aneurysmal subarachnoid hemorrhage (SAH) since January 1999 in our institute. Twenty patients rebled after admission before surgical clipping, and these patients formed our study group. The findings were compared with all the major series on rebleeding published in literature. Results: Since January 1999, 952 patients underwent treatment for aneurysmal subarachnoid hemorrhage in our institute. Twenty patients rebled while awaiting surgery following the admission with an incidence of 2.14%. The study group included nine males and eleven females. The age of the patients ranged from 31 to 69 years, but the majority were in the sixth decade. Mean bleed to admission days was 7.9 days (range: 1-27 days), the mean admission to rebleed was 1.42 days (Range: 0-4) and the mean first bleed to rebleed was 9.26 days. The history of loss of consciousness at the time of bleeding was observed in 16 patients. Four patients bled before an angiogram could be performed. Two patients had giant aneurysms, while the rest had small aneurysms; two patients had multiple aneurysms. Angiographic spasm was observed in eight patients. In three patients, rebleeding was precipitated by angiogram. Twelve patients rebled while taking rest or in sleep, while one person rebled while defecating. Nine patients were taken up for emergency exploration immediately after rebleeding. From these, six patients died and three survived, but were severely disabled. The remaining eleven patients who were conservatively treated expired after varying periods of intensive care. Conclusions: Our incidence of rebleeding (2.14%) is considerably less than most of the other reported series, probably related to the delayed referral pattern. Probable predisposing factors for rebleed include old age, female sex and an anterior communicating artery location. Known risk factors such as hypertension, poor neurological grade on admission, stressful activity and aneurysm morphology do not appear to be significant in our study. Outcome is extremely poor following the rebleeds, either in immediate surgery or conservative treatment.
AB - Background: Rebleeding is an important cause for mortality following aneurysmal subarachnoid hemorrhage. Early intervention is believed to reduce the risk of rebleeding. However, in developing countries such as India, early intervention is often difficult due to various reasons. The knowledge about the risks and predictors for rebleeding is essential to prioritize the management policy. Aims: To describe the frequency and impact of rebleeding in the modern era of aneurysm care, to study the clinical profile of patients with rebleed and to review the controversial aspects on aneurysmal rebleed. Materials and Methods: This observational study is based on the retrospective analysis of the case records of all patients admitted with aneurysmal subarachnoid hemorrhage (SAH) since January 1999 in our institute. Twenty patients rebled after admission before surgical clipping, and these patients formed our study group. The findings were compared with all the major series on rebleeding published in literature. Results: Since January 1999, 952 patients underwent treatment for aneurysmal subarachnoid hemorrhage in our institute. Twenty patients rebled while awaiting surgery following the admission with an incidence of 2.14%. The study group included nine males and eleven females. The age of the patients ranged from 31 to 69 years, but the majority were in the sixth decade. Mean bleed to admission days was 7.9 days (range: 1-27 days), the mean admission to rebleed was 1.42 days (Range: 0-4) and the mean first bleed to rebleed was 9.26 days. The history of loss of consciousness at the time of bleeding was observed in 16 patients. Four patients bled before an angiogram could be performed. Two patients had giant aneurysms, while the rest had small aneurysms; two patients had multiple aneurysms. Angiographic spasm was observed in eight patients. In three patients, rebleeding was precipitated by angiogram. Twelve patients rebled while taking rest or in sleep, while one person rebled while defecating. Nine patients were taken up for emergency exploration immediately after rebleeding. From these, six patients died and three survived, but were severely disabled. The remaining eleven patients who were conservatively treated expired after varying periods of intensive care. Conclusions: Our incidence of rebleeding (2.14%) is considerably less than most of the other reported series, probably related to the delayed referral pattern. Probable predisposing factors for rebleed include old age, female sex and an anterior communicating artery location. Known risk factors such as hypertension, poor neurological grade on admission, stressful activity and aneurysm morphology do not appear to be significant in our study. Outcome is extremely poor following the rebleeds, either in immediate surgery or conservative treatment.
JO - Annals of Indian Academy of Neurology
JF - Annals of Indian Academy of Neurology
Menon GR, Nair S, Rao RM, Abraham M, Easwer HV, Krishnakumar K. Patterns and predictors of in-hospital aneurysmal rebleed: An institutional experience and review of literature. Annals of Indian Academy of Neurology. 2007;10(4):247-251. https://doi.org/10.4103/0972-2327.37817
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Sónar Barcelona 2018 - Beyond a birthday celebrationWords by Marjolijn Oostermeijer & Arnau Salvadó
Sónar Barcelona 2018
Beyond a birthday celebration
Sadness has taken over now that the 25th edition of Sónar Barcelona has ended. The much-awaited festival came and went as fast as the bpms of most DJ sets we danced to. From June 14 to 16, the Mediterranean city celebrated one of the most important landmarks in its musical history: it was the festival’s anniversary and the most attended edition as well, with more than 126.000 people. With performances by Gorillaz, Richie Hawtin, Yaeji, 2manydjs, Laurent Garnier, Rosalía, or Ben Klock, this is another one for the history books.
Planning to start the day with a concert instead of a DJ set, we first attended Putochinomaricón’s performance at the young stage SonarXS, where the most alternative and niche proposals take place. The emerging and politically-driven singer (his artistic name means, literally, ‘fucking-Chinese-faggot’) offered a very charismatic as well as punk performance. With incredible, full-face makeup resembling that of the Chinese opera, Chenta Tai (his real name) proved he’s a one to watch in the years to come.
After him, it was time for Rainforest Spiritual Enslavement. The American producer is known for his mysterious ambient tunes, which he samples mostly from nature. Especially for Sónar, he teamed up with Silent Servant and Low Jack, and the trio exceeded far above our expectations as ambient electronics where quickly replaced by dark and industrial beats that never lost their air of mystery, nor the nature sounds you would normally only hear in a rainforest.
Already tired from all that dancing, we went outside for a little break. Our spirits were soon lifted by the upbeat house tracks of a much-anticipated newcomer. Yaeji managed to get the entire SonarVillage bouncing up and down to her unique blend of hip-hop, trap and house, singing live to all of her tracks and providing a surprisingly strong and sparkling presence on stage. The American-Korean DJ was followed by George Fitzgerald, who was presenting his newest album, All That Must Be, which was a bit too relaxed after Yaeji’s set. That’s why we preferred to close the first day of the festival at Agoria’s set at SonarHall. For the first time at Sónar, Sébastien Devaud performed live, a challenge that proved his mastery when it comes to transcending his usual role as a DJ.
On Friday, we started in the sunny, open-air stage that is SonarVillage. The London DJ Jamz Supernova, an emerging creative in the always boiling British scene, took off the set with Blink, a song by the local-artist-turned-international-star Bad Gyal. From here, it only got better: hip-hop, dancehall, and other bouncing rhythms made us forget the first day’s hangover. We stayed at SonarVillage to listen to Kampire, a queer feminist DJ from Uganda whose set shone because of its magnificent music choice, all coming from the African continent, showcasing its endlessly rich variety of genres, styles and rhythms.
We split between her and the b2b taking place at SonarDome. Clip and Cora Novoa, two Spanish DJs, were on the musical antipodes of Kampire: if the latter’s set was tropical and happy, the formers’ was destructive and dark. Even though it was a bit too early for us to take that upbeat techno in, we stayed long enough to enjoy it and wish for the night to come. But we had to attend other performances first, like the one by Rosalía.
The emerging Spanish singer presented exclusively the first glimpse of her upcoming album, Malamente, which is expected to be an instant success. Taking into account the long queue and frenzy that preceded the concert, it certainly will be. Originally from a town near Barcelona, she showcased her undeniable talent mixing strikingly beautiful and sensitive vocals, never-before-heard songs, and a group of dancers and performers surrounding her that turned the show into what you would expect from an international star. Now, we’ll just have to wait until the album is released by the end of the year.
After her, it was Sophie’s turn. Back at SonarDome, the British producer, singer and DJ offered a performance difficult to label. With an all-female cast dressed in fetishist ensembles, Sophie sang, danced and defied the status quo with an irreverent, strong, and unique show. The visuals of some of her music videos, like Faceshopping, were the perfect complement to her distorted, almost robotic voice.
At SonarXS, the Colombian Rosa Pistola turned up the heat even more – if that’s possible. Playing an amazing set of hard, sweaty reggaetón, the audience went nuts dancing ‘perreo’ non-stop. It was amazing to see how almost everyone sang to the lyrics and danced with each other as if it were an intimate club. The best way to close the day, though, was with a bit of fresh air at SonarVillage with the eclectic set of South-African DJ Black Coffee. Pure class and mastery.
We couldn’t start Friday’s night without seeing Gorillaz. After seven years of silence, in 2017, the music group finally made a comeback with Humanz, an entirely new album. But in their concert at Sónar, of course, they played several of their hits, like On Melancholy Hill or Clint Eastwood, combined with newer songs like Saturnz Barz and Ascension. You could feel how much their performance was awaited: the audience sang along (or screamed) each and every track, the excitement was palpable, and the energy after it was over was still pumping. Gorillaz were definitely one of the highlights of the entire festival.
SonarClub started filling up as the first melodic tones of Bonobo’s performance rippled through the sound system. Although his set was a bit more downtempo than the high bpm we had gotten used to at Sónar, it was not any less captivating. Playing a live set, Simon Green took us on an electronic expedition filled with an abundance of powerful hits from his latest album, titled Migration, and creating a slightly melancholic yet beautiful and dreamy setting.
Right before Bonobo played his last notes, we made our way to Bicep, another member of the legendary label Ninja Tune. The Irish duo played a strong live set filled with their iconic blend of house, techno and a hint of acid. What really made them stand out, however, was the way they played in on the audience. Something that could have not been easy, considering the immense size of the crowd. As Bicep shifted their songs from garage and techno to a more euphoric acid and Italodisco, the crowd’s mood shifted along with it, finally going into a frenzy when they dropped their famous classic Just.
After this amazing set we barely had the energy left to stand, but we were motivated by the prospect of techno veteran Helena Hauff. She didn’t disappoint as she brought us two hours of industrial techno, darkwave and garage sounds that belonged somewhere in the basement of an underground club in Hamburg, but still managed to work during a sunrise at Sónar. As the sky became lighter, her music only became darker and her heavy techno provided the perfect ending to our night.
On Saturday, urban music and the newest musical trends took over. We could listen to rapper, hip-hop and trap singers like Rels B and Steve Lean, two Spanish emerging stars. Their new takes on the music genres have turned them into some of the most interesting talents to watch, especially for the youngest audience, who seems obsessed with them. Breaking from the usual sexist lyrics and roles of women in urban music, the Argentinian Nathy Peluso showed how liberated women do it on stage. With massive hits like Corashe and La Sandunguera, she drove everyone’s crazy with sensual moves and the most irreverent attitude.
After the urban concerts, we moved to more electronic-oriented performances. SonarComplex was the perfect place to do it, as DJ Stingray was doing a b2b with Mumdance. The Detroit legendary DJ teamed up with the British producer to offer an unforgettable set of industrial, hard techno that set the tone for the next one: 2manydjs. The Belgian brothers were some of the most expected performances of the 25th-anniversary-edition of the festival, and they were up to the expectations: extremely charismatic, their danceable, eclectic DJ set was the perfect way to finish the last Sónar by Day.
We started out our Saturday night with American-English punk-funk gods LCD Soundsystem, whose return to Sónar was very much anticipated. The indoor space of SonarClub had filled up to the edges with an attentive audience. Drinks in hand, they were focused on the stage or large screens that showcased the band, and listening to their unique blend of rock, funk and punk. The dedication of the audience in combination with the lyrical rock of LCD Soundsystem made the performance feel like a concert rather than an act at a festival.
The mood changed when we attended Tokimonsta at SonarPub. The American DJ and producer was presenting her audio-visual show for the first time outside of the United States, and it caused a stir. The audience seemed to fall in love right after an instrumental introduction by violins and a piano that quickly turned into her song We Love, feat. MNDR. Later on, her repertoire continued with many hip-hop and rap iconic songs like Get Ur Freak On, by Missy Elliott, or more tribal tracks like Work!, by Gigamesh feat. Kaleena Zanders. And the visuals, one of the most important parts of the show, left everyone mesmerized.
London-born DJ Call Super may have not been one of the most well-known names gracing Sónar’s line-up, but as his set progressed more and more people became captivated by his blend of techno and ambient and the SonarClub space filled up in no time. Call Super’s deep knowledge of technological music became evident throughout its incredibly precise and well-calculated mix that eased in the audience with soft and ambient tunes that slowly progressed into a dark technological set managed to get everyone dancing.
Octo Octa was also very knowledgeable. The American DJ played analogue, showing how her ten-year-career has taught them more than the basics behind the decks. Despite her style is usually characterized by house music, her set at Sónar also included harder, more industrial sounds. After she had finished, there was very little of the usual movement from stage to stage. This wasn’t at all odd, considering next up was a b2b set featuring two of the industry’s most respected DJs.
Berghain resident Ben Klock and Japanese underground mastermind DJ Nobu started off with a calm song that quickly increased in speed and volume. What followed was almost two hours of uninterrupted, dark and underground techno that combined Ben Klock’s love for deep grooves with DJ Nobu’s more abstract sounds, and came together in a qualitative collision of German precision and Japanese craftsmanship.
We still remained at the SonarLab stage for a duo that couldn’t be more opposite from the one that came before. Motor City Drum Ensemble and Jeremy Underground had played many great b2b sets in the past, and this one was no exception. The duo dropped a continuous stream of house and disco classics as the sun came up, and the joyfully dancing crowd was the best we’ve encountered the entire festival. A little bit before them, though, we went to see Richie Hawtin’s new show, titled Close. With lots of gear and hardware on stage, the veteran DJ showed his most skilful, technical side as an electronic creative, moving between his usual tracks and more robotic-like sounds.
The great master was followed by none other than Charlotte de Witte. Some people were doubting that after Hawtin’s performance anyone could meet the expectations. But she certainly did. SonarClub was packed and remained like that: almost everyone wanted to finish such an amazing edition with one of the hardest sets of the festival. Charlotte proved that, despite being very young, she’s got the temper, skills, and attitude to offer the audience what it wants: a larger-than-life closing that makes us forget our environment and just dance, dance, and dance. A perfect ending to an edition full of masterly performances. With Charlotte, we said goodbye to Sónar Barcelona and its twenty-five-year celebration. We’ll wait anxiously until the confirmations for 2019.
Marjolijn Oostermeijer & Arnau Salvadó
Ariel Martini, Alba Rupérez, Fernando Schlaepfer, Nash Does Work, Samuel Smelty
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Termite gut
2 Description of Niche
2.2 Physical Conditions
2.3 Any adjacent community affects it? And do these conditions change or are they constant?
3 Who lives there?
3.1 Which microbes are present?
3.2 Do the microbes that are present interact with each other?
3.3 Do the microbes change their environment?
3.4 Do the microbes carry out any metabolism that affects their environment?
Termite has unusual characteristics of establishing themselves in lignocellulosic plant materials such as decaying wood, grass, animal dung or plant litter at various stages of humification. Despite their strange habitat, they play an important role as distributors of terrestrial decomposers of Earth’s major form of biomass. Termites are usually rich in carbon due to their diet; however, this also led to insufficient amounts of nitrogen. Facing this serious problem, many termites established symbiotic interactions with gut microbes to augment their nitrogen economy through recycling of uric acid and the acquisition of new nitrogen through N₂fixation.
Description of Niche
Termite has unusual characteristics of establishing themselves in lignocellulosic plant materials such as “decaying wood, grass, animal dung or plant litter at various stages of humification.” (10) Despite their strange habitat, they play an important role as distributors of terrestrial decomposers of Earth’s major form of biomass. Termites are usually rich in carbon due to their diet; however, this also led to insufficient amounts of nitrogen. Facing this serious problem, many termites established symbiotic interactions with gut microbes to augment their nitrogen economy through recycling of “uric acid and the acquisition of new nitrogen through N2 fixation.” (11) Termite’s intestinal tract consists of three main parts: foregut, midgut, and hindgut. Foregut is composed of the crops and muscular gizzard, midgut is “a key site for secretion of digestive enzymes and for absorption of soluble nutrients,” and hindgut is “also a major site for digestion and for absorption of nutrients.” (12) Among these intestinal tracts, hindgut is known to be largest and have been thought of as “anaerobic digestors in which symbiotic gut microbes depolymerize cellulose and hemicellulose and ferment the resulting carbohydrates to short-chain fatty acids, which are then absorbed and oxidized by the host.” (10) Additionally, termite’s intestinal tracts comprise one or several dilated hindgut compartments and the volume of hindgut can be up to one-third of the body weight for phylogenetically low termites. It is said that termite gut resembles the rumen of sheep or cattle due to their “high concentrations of volatile fatty acids, the presence of fermenting bacteria and protozoa, and the occurrence of typical anaerobic activities such as homoacetogenesis and methanogenesis.” In the phylogenetically lower termites, anaerobic flagellates are present in a large fraction of hindgut volume. These flagellates phagocytize and degrade the wood particles comminuted by the termite. Nevertheless, a hylogenetically higher termite doesn’t compose of flagellates within their gut. (10)
Due to the small size of termites, analyzing termite guts have been very difficult without invasiveness techniques. Nonetheless, it became apparent that termites’ guts have a characteristic of being anoxic. “This characteristic becomes more apparent as one move from the foregut to the hindgut, and is greatest within microbe-packed portions of the hindgut.” Termites’ guts have anoxic conditions because of their steep oxygen gradients at the oxic-anoxic interface drive a continuous influx of O2 into the gut. Through examining termite guts with microsensor, it became evident that O2 may travel 50-200 um into the gut until it is used by the respiratory activity, creating a microoxic periphery around an anoxic center. “Radiotracer studies performed with the lower termite Reticulitermes flavipes have shown that the influx of O2 via the gut epithelium and its subsequent reduction in the hindgut periphery has a significant impact on carbon and electron flow within the hindgut microbial community.” (10) Although it became evident that termite gut has anoxic conditions, additional analyses were revealed by Bignell. According to his studies, microbe-filled paunch region of lower and higher termites yielded not completely anoxic conditions, but had a microoxic periphery. Through studies, Bignell and others indicated that pH and redox potential demonstrated significant transitions along the anterior to posterior axis of termite guts. However, the paunch region’s measurements were circumneutral and anoxic with a relatively low redox potential of -150 to -250mV. (3) The pH values of hindguts also showed neutrality: 6.2 to 7.6. (12)
This neutral pH value of hindgut can be altered if an environment changes. As some termites relies their diets on soil, soil-feeding termites’ hindgut pH value can be high as 11. (12) Soil-feeding termite exhibits extreme pH changes along the gut axis. Their anterior hindgut exhibits the most extreme alkalinity. This high pH transitions along the gut axis can be viewed as an evolutionary adaptation to “diet rich in tannins or other polyphenolic constituents” because it prevents precipitation of digestive enzymes and enhances the solubility of dietary proteins. As soil-feeding termite ingests soil organic matters, it needs to stabilize organic matters. Termite accomplishes this by alkaline extraction since alkaline in their gut separates organic nutrients from the organomineral aggregates. (13) These soil-feeding termites have other differentiations than wood-feeding termites. Although many of the phylogenetically higher termites are wood-feeding termites at various stages of humification and decay, more than half of all termites are soil-feeders. These humivorous termites’ gut is “highly compartmentalized and characterized by pronounced axial dynamics of the O2 and H2 partial pressure, and intestinal pH.” Due to these differences, production of H2, methanogenesis, and reductive acetogenesis by microbes in humivorous termites’ gut are unevenly distributed. (11) As these two different conditions establish differentiation among termites, other external factors can also distribute effects. For an example, as more and more H2 are added externally, methane emission rates of live termites are considerably stimulated. Despite the changes of emission rate of methane by H2, reduction of acetogensis from 14CO2 remains unaffected. (10)
Any adjacent community affects it? And do these conditions change or are they constant?
Many termites have close relation with tropical forest communities as they need woods and soils to acquire energies. As tropical forests contain numerous dry woods and plenty of soils, most of termites establish close relationship with them. Although many assume termites are voracious consumers of wood and they are correct, most termites have positive effects on tropical forests as they provide soil fertility. Additionally, their nests provide shelters and food for numerous numbers of associated organisms. Other communities that have significant affects on termites are microbes that live within them. Most of microbes establish themselves in termites’ gut and form symbiotical relationship with termites. They provide nitrogen and facilitate intake of numerous energies as termites can’t accomplish it alone. For an example, “the cellulolytic flagellates degrade cellulose to produce acetate, which is in turn absorbed by termites as their energy and carbon source.” (11) This symbiotic relationship of termite and microbes is constant because of their necessities from each other to survive. Without any individual, microbes and termites can’t acquire necessary nutrients in order to survive.
Who lives there?
Termite, gut and microscopic image (14)
Which microbes are present?
Termite gut exhibits one of the most complex microbial communities, consisting of diverse microorganisms from all three domains of life: Bacteria, Archaea, and Eukarya. By extracting DNA from the gut and comparing sequences of 16S rRNA genes with databases of rRNA sequences, predominant microorganisms in the gut community has been identified as well as their funcitons in the termite gut(1):
Domain Genus,Species Brief Descriptions/Functions of Microbes
Bacteria Treponema Swim freely in the gut or attached to the protist; acetogenic, carry out acetogenesis
Bacteroides, Bacteroides termitidis Fermentative, acidogenic; increase N source by recycling uric acid waste
Desulfovibrio Sulfate-reducing bacteria; transfer hydrogen as H₂ donor
Citrobacter, Citrobacter freundii, Enterobacter, Enterobacter agglomerans Nitrogen-fixing bacteria
Enterococcus, Lactococcus Lactic acid bacteria
Archaea Methanobrevibacter Metanogens, associated with protists as symbionts; carry out metanogenesis and produce methane
Protists Trichonympha, Mixotricha, Dinenympha, Euconomympha Degrade endocytosed cellulose and produce H₂ plus CO₂. Anaerobic, occur on mitochondira in the cells
Do the microbes that are present interact with each other?
Interaction between the microbes in the termite gut is highly mutual, usually beneficial for both microbes.
Prokaryotes are closely associated with protists as symbionts, either attached to the cell surfaces or live within the cytoplasm or nucleus of the protists. For instance, Treponema spirochete bacteria are attached to the special bracket-like structures on the plasma membrane of mixotricha and contributes to the movement of the host protist known as “motility symbiosis”(3). Treponema also benefits by living on and within the protist, easilly accessible to nutrients H₂ and CO₂ produced by mixotricha and utilize them to synthesize acetate and obtain energy for their own growth as well (5).
Another mutual relationship shown between Methanobrevibacter and parabasalids protist, H₂ plus CO₂ produced by protists also can be used by methanogens as energy source but they form methane,CH₄ in this case. Successful elimination of produced H₂ by endosymbiont’s H₂ evolution activity enables the protists to maintain optimal pH and stimulate its decomposition activity (4). These two groups of microorganism interact and work together to digest cellulose and enhance the cellulose fermentation.
Although most of the microbes act mutually, there is one exception between the relationship of methanogens and acetogens. Both take up H₂ and CO₂ as their substrates, thus they are likely to be in a compete relationship. Acetogenesis dominates methanogenesis from the same substrate, H₂ plus CO₂, because acetogenesis requires less energy loss of the termite by absorbing acetates but not methane as the energy source.(4)
Do the microbes change their environment?
The genus Treponema contains motile spirochetes that are embedded in the host’s cell membrane. They work as ectobionts to provide locomotion of the host cell by moving synchronizedly. Such relationship is known as the motility symbiosis (8).
Termites are on the nitrogen poor diet. Hence, the functional group of nitrogen fixers is essential to supplement a sufficient amount of nitrogen to the host protists. Treponema, Citobacter, Enterobacter, and Spirochaeta are some of the responsible nitrogen fixers. These microbes convert N2 from the atmosphere to NH3 and fix ~60% of the nitrogen supply of the host (7).
In the protest Pseudotrichonympha grassii, there are two gens enconding hydrogenosomal iron-hydrogenases. Two iron-hydrogenases are responsible for retaining optimal pH within the hydrogenosome in the protest cell. These enzymes catalyze H2 evolution instead of H2 uptake (6).
Do the microbes carry out any metabolism that affects their environment?
Termite Gut Metabolism (15)
1. Nitrogen fixation and recycling of uric acid nitrogen
N₂ fixation is one of the crucial aspects of termite gut symbiosis, because termites feed on the nitrogen poor environment. The Nitrogen fixing bacteria such as Citrobacter freundii, Enterobbacter agglomerans, and Spirochaeta possess nitrogenase which reduces N₂ to 2NH₃, providing nitrogenous compounds that TG1 cannot synthesis. They play significant role in converting stable atmospheric nitrogen into something that host protists can uptake in order to supply the nitrogen need. Also, because the supply is so scarce, most of the nitrogen is recycled through the uric acid recycling to minimize the nitrogen loss. Generally, the required nitrogen fixation is low comparing to the high concentration in the termite due to the recycling of the uric acid (7).
2 .Acetogenesis/Methanogenesis
Both H₂/CO₂ acetogenisis and methanogenesis are anaerobic metabolism pathway that utilizes H₂ plus CO₂ generated by host protists during cellulose fermentation to synthesize acetate and methane, respectively. Prokaryotes associated with protists as symbionts are key microbes that are responsible for mediating these biosynthesis. Treponema acts as acetogens and carrys out acetogenesis by reducing CO₂: 4H₂ + 2CO₂ -> CH₃COOH + 2H₂O. Methanobrevibacter takes more of methanogenic role and also uses H₂ as its reducing agent for methane production: 4H₂ + CO₂ -> CH₄ + 2H₂O (3). Since the termite only can absorb acetate as its energy source, acetogenesis dominates methanogenesis in the termite gut to reduce energy loss as much as possible. Thus, only 1% of the carbon generated by microbes is lost in form of CH₄ and the rest 99% C source are emitted as CO₂ (3). But it appears to be that even small amount methane emitted by archaea-mediating metanogenesis are considered to be significant atmospheric methane source.
3. Cellulose degradation
Protists reside in the termite gut ingest wood particles in the form of cellulose and degrade it within their cells. Cellulolytic protists known as Trichonympha and mixotricha produce cellulases and various glycolytic enzymes that can break down cellulose and convert it into an intermediate product, malate (2). In addition, they carry specific anaerobic energy- generating organelle, hydrogenosome, where transferred malate from the cytoplasm is further fermented to produce CO₂, H₂, and acetate with the help of hydrogenase enzyme. During this fermentation process, ATP is also produced in the way and stored as energy available for both microbes and termite (2).
The current research on the metagenomics is studying the DNA sequence of the termite gut to identify the microorganisms living in the termite which can be useful to produce the biofuel in the future. The identifying and studying microbes were the hardest part in the past, since only about 1 percent of the microbes were lab-cultivatable. However, the current fast and cheaper ways of gene sequencing methods have allowed microbiologists to study the other 99 percent. Scientist can extract the DNA from a certain sample, sequence that DNA, and derive the genomic clues to all microbes living in that certain environment. The microbes in the termite gut have ability to digest wood, such as converting cellulose into simple sugars that can be turned into ethanol by fermentation. Because “Termites are the world’s best bioconverters,” (9) the researchers are devoting their works to sequence the microbes to make the biofuel. Recently, researchers at the Joint Genome Institute have just finished sequencing the microbial community of the termite gut and have already identify a number of novel cellulases which breakdown cellulose into sugar. Their next goal is to adequately modify and use the microbes to synthesize an ideal energy producing organism (9).
(1) Ohkuma, M., and Kudo, T. “Phylogenetic Diversisity of the Intestinal Bacterial Community in the Termite Reticuliterrmes speratus”. Applied and Environmental Microbiology, p.461-468 (1996).
(2) Ohkuma, M. “Metabiolic Symbiosis between Termite Gut Protists and Their Intracellular Bacteria”. Noda Institute for Scientific Research, p.35-36 (2006).
(3) T. Abe, D.E. Bignell, and M. Higashi: Termites: Evolution, Sociality, Symbioses, Ecology. Kluwer Academic Publishers, Dordrecht, 2000. p.209-227., p.307-332
(4) Ohkuma, M. “Symbiosis within the gut microbial community of termites.” RIKEN Review No.41. Nov. 2001, p.69-72.
(5) Breznak, J. A. “Phylogenetic Diverisity and Physiology of Termite Gut Spirochetes.” Integ. And Comp. Biol, 42:313-318 (2002)
(6) Michael Pester and Andreas Brune. “Hydrogen is the central free intermediate during lignocellulose degradation by termite gut symbionts.” The ISME Journal (2007) 1, 551-565.
(7) John A. Breznak. “Phylogenetic Diversity and Physiology of Termite Gut Spirochetes.” Integ. And Comp. Biol., 42:313-318(2002)
(8) Claudia Husseneder, Billy R. Wise, and Dennis T. Higashiguchi. “Bugs in Bugs: The Microbial Diversity of the Termite Gut.” Proc. Hawaiian Entomol. Soc. (2007) 39:143-144
(9) Emily Singer. Why Termite Guts Could Bring Better Biofuels. Technology Review. Jan 17, 2007
(10) Brune, Andreas. “Microecology of the termite gut: structure and function on a Microscale.” Current Opinion in Microbiology 3:263-269 (2000)
(11) Brune, Andreas. “Termite guts: the world’s smallest bioreactors.” Tibtech 16 (1998)
(12) Breznak, John A. “Role of microorganisms in the digestion of lignocellulose by termite.” Annu. Rev. Entomol. 39:453-87 (1994)
(13) A. Kappler. “Influence of gut alkalinity and oxygen status on mobilization and size-class distribution of humic acids in the hindgut of soil-feeding termites.” Applied Soil Ecology 13:3 (1999)
(14)"Microbiologists find a New Source of Nitrogen Fixation" June 28, 2001 <http://www.nsf.gov/od/lpa/news/press/01/pr0154.htm>
(15) Termite Power. Biology at JGI <http://www.jgi.doe.gov/education/bioenergy/bioenergy_4.html>
Edited by Kevin Cho, Seyon Kim, Jee Shin, students of Rachel Larsen
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View source for workofart-brainstorming
← workofart-brainstorming
= Work of Art Brainstorming = This page is for brainstorming about ideas, proposals, constraints, and requirements for a work of art microformat. This is part of a community effort to create a [[work-of-art]] microformat. (See also: [[workofart-examples]], [[workofart-formats]].) == Participants == * [[User:TimG| Tim Gambell]] * Samantha Orme == The Problem == Many art museums use metadata to describe the works of art in their collections. However, the presentation of works of art on the web often does not benefit from that formalized categorization work. We'd like to develop a xhtml markup standard for the presentation of works of art on the web. == Use Cases == Why bother with a microformat for works of art? What problems will it enable us able to solve? What new tools will it enable us to build? === The Metamuseum === A work of art microformat turns the art on museum websites into the building blocks of a web based "metamuseum" -- an interface to the works of art on the web. === The Work of Art Aggregator (+ XSLT = Flash Cards) === "I'm a college student who takes art history courses. At many times I have been presented with the problem of creating flash cards for the exams in these courses. How much time I could have saved with a work-of-art aggregator, and an xslt sheet which could produce printable flashcards automatically from the wide range of art sites out in the wild." -- from [http://microformats.org/discuss/mail/microformats-discuss/2006-March/003422.html this post] on the microformats [http://microformats.org/mailman/listinfo/microformats-discuss/ discuss list] === Research (and Publicity for Smaller Collections?) === "I mentioned previously that I would be shortly redesigning an art gallery's website making heavy use of microformats. I was just informed that they want to reproduce photographs of all the art and sculpture from each artist for the purposes of working with clientelle in making an informed decision about the purchase of art work. With a microformat as a guide to "best practices" such a catalogue could easily be collected into a searchable database." -- from [http://microformats.org/discuss/mail/microformats-discuss/2006-March/003422.html this post] on the microformats [http://microformats.org/mailman/listinfo/microformats-discuss/ discuss list] === Galleries === I'd guess that it's more common for multiple works of art to be viewed on a single web page than it is for a single work to be viewed on a single page. In real life, multiple works of art can be combined to make a gallery. The work of art microformat should be designed so that it's easy to combine multiple xhtml works of art into an xhtml gallery (perhaps using something like the hAtom format to tie the pieces together). == Discussion == === What should work of art be based on? === * What is the best of the existing metadata schema to use as the basis for the work of art microformat? ** Consensus seems to be building around using [[citation]] for the basic terms. See the discussion below. -- [[User:TimG | Tim]] === Integration of other microformats === * What is the best way to integrate existing microformats into the work of art microformat? For example, would it be appropriate to use the hCard microformat to identify the artist? To identify the work of art's location? === What about [[citation]]? === * [[User:RCanine|Ryan Cannon]] proposes that work-of-art could be produced as a special case of the [[citation]] microformat. * I propose that work-of-art should be (more specifically) an ''extension'' of the [[citation]] microformat. I propose that the goal of work-of-art be to create a simplified version of [http://www.getty.edu/research/conducting_research/standards/cdwa/ CDWA], whose core components are those parts of CDWA that are most commonly used when representing a work of art online. However, work-of-art should be extensible such that any work of art may be accomodated. Essentially, work-of-art should strongly encourage the use of its core components (for consistency), but allow additional elements for those cases in which they are strictly necessary. Opinions on the utility and/or drawbacks of being all-inclusive are requested. [ [http://www.19clicks.com Samantha Orme] ] ** One of the core principles behind microformats is the reuse of existing standards. [[hCard]], for example, is almost a 1:1 reimplimentation of the vcard standard. The proposal that we base this format on [[citation]] raises the question: is it better to reuse an existing microformat or to reuse some purpose built format (like CDWA)? -- [[User:TimG|Tim]] *** The existence of [[existing-classes]] suggests that we're supposed to reuse existing microformats first, before referring to purpose built formats. -- [[User:TimG|Tim]] **** That's correct Tim, reuse existing microformats first. This is explained more thoroughly as [http://microformats.org/wiki/naming-principles#Reuse_Microformats_First.2C_Other_Standards_Second part of naming-principles] - Tantek ** Are museums more likely to adopt a standard that is easy to understand and read or one based on an existing standard designed for museums? -- [[User:TimG|Tim]] *** I think it all depends on the complexity and ease of use. Microformats out-do existing legacy formats (even when based on those legacy formats!) purely because they are simpler to author, and provide a much lower barrier to entry and understanding. - Tantek *** Simpler to author and understand is always better. The shorter the spec, the more likely it is to be implemented! [[User:FrankieRoberto|FrankieRoberto]] (Science Museum, which holds more works of art than you'd think) ** I'm not exactly sure what you mean by extensions. If you mean informal extensions, I think we're better off not sanctioning them. The only fields that are going to be really useful (from a readers/parsers point of view) are the ones that are consistenly applied (the core components you propose). However, if you mean extensions like this microformat is an extension of the [[citation]] microformat (that is, developed using the microformats process), I agree completely. Your thoughts? -- [[User:TimG|Tim]] == Proposals == === [[citation]] + [http://dublincore.org/documents/dcmi-terms/ Dublin Core] Strawman === * A suggested starting point for the core components of work-of-art. Components are, where possible, either similar to those that are under consideration for inclusion in [[citation]], or part of the Dublin Core. The Getty's [http://www.getty.edu/research/conducting_research/standards/intrometadata/3_crosswalks/crosswalk1.html Metadata Standards Crosswalk] was also taken into consideration. Feedback is welcome. * Questions: ** Is some loss of semantic granularity an acceptable trade-off for microformat clarity? (i.e. should we combine components that would be distinct in a CDWA-based schema?) *** I think the trade off is acceptable. In a nod toward this issue, CDWA makes a distinction between fields intended for indexing (more granular) and fields intended for display (more human friendly). In the CDWA strawman, I opted to use the human friendly/ less granular "display" fields. -- [[User:TimG|Tim]] ** Should creater information rely on an hCard extension for historical figures? It seems as though hCard with the addition of nationality, vital dates, gender, and role have utility in alternative contexts. *** I think creator information should rely on hCard to the extent that hCard can already handle it. An hCard extension for historical figures would be very useful for us here, but I'd argue it's outside the scope of this microformat. What do you think? -- [[User:TimG|Tim]] *** We ought to follow the discussion over at [[hresume|hResume]]. Their approach combines [[hCard]] with [[hCalendar]]. With the addition of nationality, vital dates, and gender it would provide a framework for the bio files many museums keep on the artists in their collections. ''hBio'' anyone? -- [[User:TimG|Tim]] {| border="1" cellpadding="3" cellspacing="2" | '''Component''' || '''Notes''' || '''Approximate CDWA equivalent''' |- | title || || [Title or Names] |- | creator || [[hCard|(hCard)]] || [Creation-Creator] |- | creator-dates || (dates) || [vitalDatesCreator] |- | creator-nationality || || [nationalityCreator] |- | creator-role || || [roleCreator] |- | subject || keywords (using [[rel-tag]]?) || [Subject Matter] |- | description || || [Descriptive Note] |- | date || (date created OR earliest date) || [Creation-Date] |- | latest-date || (latest date) || [Creation-Date-Latest Date] |- | type || (genre/style) || [Classification] [Styles/Periods] [Object/Work Type] |- | format || (dimensions) || [Measurements] |- | medium || (media / techniques) || [Materials and Techniques] |- | identifier || (repository number / accession number) || [Current Location-Repository Numbers] |- | source || (current repository) || [Current Location-Repository Name] |- | source-location || (current repository location -- [[adr]] or [[geo]]?) || [Current Location-Repository Location] |- | language || || |- | rights || (copyright information) / [[rel-license]]? || [Copyright/Restrictions] |- | provenance || || [Ownership/Collecting History-Description] |- | series || (connect artworks that are part of a series) || [Related Works] |} [ [http://www.19clicks.com Samantha Orme] ] === [http://www.getty.edu/research/conducting_research/standards/cdwa/cdwalite/index.html CDWA Lite] Strawman === [http://microformats.org/wiki/class-design-pattern Use class names] based on the [http://www.getty.edu/research/conducting_research/standards/cdwa/cdwalite.html CDWA Lite 1.1 XML Schema]. This example is based on [http://www.getty.edu/research/conducting_research/standards/cdwa/3_cataloging_examples/examples/04_watercolor_turner.html a CDWA example] <pre> <nowiki> <span class="cdwalite"> <span class="objectWorkTypeWrap"> <span class="objectWorkType">watercolor</span> </span> <span class="titleWrap"> <span class="titleSet"> <span class="title">Conway Castle, North Wales</span> </span> </span> <span class="displayCreator">Joseph Mallord William Turner (British painter, 1775-1851)</span> <span class="displayMeasurements">53.6 x 76.7 cm (21 1/8 in. x 30 1/8 in.)</span> <span class="displayMaterialsTech">Watercolor and gum arabic with graphite underdrawing</span> <span class="styleWrap"> <span class="style">Romanticism</span> </span> <span class="descriptiveNoteWrap"> <span class="descriptiveNoteSet"> <span class="descriptiveNote">This is the largest of Turner's four extant watercolors of this medieval...</span> </span> </span> <span class="locationWrap"> <span class="locationSet"> <span class="locationName currentRepository">J. Paul Getty Museum (New York, New York, USA)</span> <span class="locationName repositoryLocation">Los Angeles (California, USA)</span> <span class="locationName repositoryNumbers">95.GC.10.</span> </span> </span> </span> </nowiki> </pre> Unresolved issues in CDWA Lite Strawman: * Is the markup prohibitively complicated? * Are wrap tags (such as "objectWorkTypeWrap", "titleWrap" etc) necessary? * Are display tags (such as "displayCreator") preferable to indexing tags? (See the [http://www.getty.edu/research/conducting_research/standards/cdwa/cdwalite/index.html CDWA Lite XML Schema] for a list of display and indexing tags.) * What is the best way to deal with attributes on xml tags (such as "type=", "termsource=" and "termsourceID=")?
Return to workofart-brainstorming.
Retrieved from "http://microformats.org/wiki/workofart-brainstorming"
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The Catholic Marriage Manual, Random House
Scholarly Resource
Post Navigation Path: / Research / Catholic Divorce / Sources Cited
6 pages (File size 2 MB)
Kelly, Rev. George.
The Catholic Marriage Manual.
New York and Toronto:
Person who believe that sufficient reasons exist to justify separation must request permission to do so from their Pastor. The pastor will refer the case to the judges of the marriage Court established by the diocese.
When civil divorce action is permitted. Church law states that Catholics may not start a civil divorce action with the intention of ending their marriage. As we have seen, a civil divorce or annulment cannot destroy the bonds of any valid marriage. In the eyes of the state, however, two persons remain married until the divorce decree is granted. Therefore it may sometimes be necessary for a Catholic to go through civil divorce proceedings in order to protect his legal rights. When the church annul a marriage and states that a true marriage never existed, for example, the parties must obtain a civil divorce in order to be free to remarry in accord with the laws of the state. In cases where the church permits a couple to separate, a wife may find it necessary to sue for divorce in order to force her husband to support her and the children.
Only a properly authorized representative of the bishop can grant permission to a Catholic to apply for a civil divorce. Church authorities require that the person involved fully understand that civil divorce cannot destroy a marriage bonds. Some diseases require that the applicant for divorce swear under oath before witnesses that he or she is initiating the action only for civil purposes.
A grave reason must exist before church authorities will approve a civil divorce application. For instance, the wife may require a court order to force her husband to contribute to her support in the form of alimony. A husband may need this protection against debts incurred by his wife.
Another requirement is that no element of scandal will be attached to the divorce action. The party to the proceedings must always make it plain, in discussing this action with friends, relatives or others, that it is taken solely for civil reasons. Catholics who obtained ecclesiastical permission to begin divorce proceedings must never give the impression to those either in or out of the faith that their action represents any departure from church teaching.
Catholic Lawyers Guide
Sacred Congregation of the Holy Office 1860
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Home » Musicians » Mariah Parker
Mariah Parker
has been playing music from the time she could reach the keys on the grand piano in her family home. While completing her degree in music at UC Santa Cruz, she worked with ethnomusicologist Fred Lieberman and drummer Mickey Hart on the “Planet Drum” project and became fascinated with the possibilities of bridging musical concepts from different traditions. She has performed her original compositions in festivals in the US and Europe. A gifted composer and band leader, she released her first solo recording of her compositions, “Sangria,” in February of 2009. Her second release, “Indo Latin Jazz Live in Concert” was released in 2017 and spend 16 weeks on the National Jazzweek Airplay chart, reaching #32. Both releases received extensive airplay and critical acclaim worldwide.
Mariah Parker piano san francisco
Live in Concert by David Becker
Mariah Parker's Indo Latin Jazz Ensemble In Live Concert Recording...
Mariah Parker's Indo Latin Jazz Quintet Returns to Yoshi's
”Parker... wrote the eight instrumental compositions on this exquisite collection of pieces that fuse Latin rhythms with influences from South America and India with a dash of straight-up American jazz. It’s an intoxicating blend of East and West performed by musicians of astounding virtuosity.” — MARIN INDEPENDENT JOURNAL
“Parker and friends blend the rhythmic syncopations of Latin jazz music with the entrancing, asymmetrical meters of East Indian rhythms resulting in first-class world music. Intriguing melodies that draw musical inspirations from the tempos of Brazil, Cuba, India, and Spain make for an uplifting serene yet passionate musical journey into an ideal world.” - LATIN BEAT MAGAZINE
“Dazzling debut..
“Dazzling debut... Parker’s subtle and sensuous sounds reflect exotic flavors of India, the Middle East and Latin America.” - PALO ALTO DAILY NEWS
“This collection of eight original instrumentals by Mariah Parker is just one of many examples of the infusion of East Indian music into Western music, but to my ears one of the most successful.” - AUDIOPHILE AUDITION
“Featuring musicians from the bands Sun Ra, Oregon, Herbie Hancock’s Headhunters and Ancient Future, Mariah Parker’s debut blends rhythmic syncopations of Latin jazz, hypnotic East Indian cadences and driving Brazilian and Afro-Cuban percussive beats. Although entirely instrumental, Sangria speaks. Maybe it’s the technical virtuosity abounding in the multiplicity of sounds” in the santur or sarangi, or the tabla or timbales. Maybe it’s in the emotive resonance of what’s behind the sounds.... Whatever it is, Parker’s Sangria is a lively, adventurous exploration into a hybrid global identity” - LEO WEEKLY
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by Alexander Day Chaffee
The new release includes a variety of noteworthy features
At this week's Java Business Expo in New York, Sun's just-released platform upgrade, Java 2, has been the core focus. Previously dubbed JDK 1.2, the new release includes a variety of noteworthy features. This week, we will look at the following:
Java for the Enterprise
Let's start with what Swing is. First there was the Abstract Windowing Toolkit (AWT), which shipped with JDK 1.0. AWT provides a core set of "widgets" (or user interface components), including buttons, windows, scrollbars, and so on. JDK 1.1 changed the event model, but left the widget set intact. Swing is a radical rewrite of the widget set.
The fundamental AWT classes -- Frame, Graphics, Image, and so forth -- are still used to manipulate pixels and to put them on the screen. However, everything that sits on top of those classes has been rewritten. (You can still use AWT widgets, but who'd want to?)
For a number of reasons, the designers of AWT used a so-called "peer architecture" to implement the core components. Each widget in the AWT does not actually draw itself, rather, it possesses a native "peer" object that interacts with the native OS widgets -- the native widgets do the actual drawing and event processing. While it was a valiant first pass, it leads directly to two major problems. First, it's impossible to extend (subclass) the various widgets. Since the OS is dealing with all the drawing and event-processing, if you wanted to design, say, a button with an icon on it, you would have to build it from scratch. Second, Java GUIs behave differently on different platforms -- they look slightly different, act slightly differently, and have slightly different bugs.
Swing fixes these problems by rewriting all the widgets from scratch for you, all in Java. There are now "J" versions of all the basic widgets -- JButton, JFrame, JList, and so on. These basic widgets all share a solid foundation of common functionality, as well as possessing many new features. For instance, all widgets are double-buffered, can have tooltips, are extensible, track the Tab key for focus, support keyboard shortcuts ("accelerators"), are customizable to specific countries, and more. JButtons and JLabels can contain icons, built from GIF files, in any orientation. JPanels can have standard borders. JMenus or JMenuBars can be added to any container. And so on.
In addition to the basic widgets, Swing adds several new ones. A JTree is a hierarchical list similar to Windows Explorer. A JTable is a row-column spreadsheet with cool features such as resizable and moveable columns. A JScrollPane allows you to scroll any container. A JToolbar is a floatable panel that contains little icons representing actions. A JEditorPane provides a fully functional HTML renderer. You can now display HTML files inside of any application or applet.
A noteworthy feature of Swing is BoxLayout, a straightforward left-to-right or top-to-bottom layout manager. If you thought Layout Managers in AWT were unnecessarily arcane, you'll appreciate BoxLayout's capability to create a rectangular partitioning of the screen simply by nesting horizontal and vertical containers. (Try this experiment: Think of any layout you could create using GridBagLayout. Now think of the same layout using nested BoxLayouts. Which was easier to code?) It also lets you do neat stuff within a container, like add "glue" and "struts" to keep the components together or apart. [*1]
Swing also adds some good fundamental GUI design concepts. All Swing widgets use a model-view-controller (MVC) architecture, making it possible to use your own data objects as the store for a JTable, for instance, rather than storing copies of your data inside the Jtable itself. MVC also allows a "pluggable look-and-feel" (PLAF), which allows a Swing app to masquerade as a Windows, Mac, Motif, or other app. An Action allows you to decouple a piece of functionality (for instance, "Save Document") from the widgets that initiate that functionality -- menus, buttons, toolbars, and so on.
Java Foundation Classes (JFC) is the set of new Java 2 services including but not limited to Swing. JFC is Swing plus Drag-and-drop plus Java2D plus Accessibility plus some other miscellaneous services such as Keyboard Navigation and Undo. In other words, Swing is in JFC, but JFC is not Swing.
Every computer science major has to take a course in Data Structures and Algorithms; every such class covers the Stack, the Queue, the Set, the Linked List, sorting algorithms, and so on. Java has finally passed CS 101. The Collections Framework provides a clean, standard, interface-based set of classes and methods that are both simple and powerful, plus a set of sorting algorithms. (You can finally sort an array!) Using the List, Set, and Map interfaces "reduces programming effort, increases performance, allows for interoperability among unrelated APIs, reduces effort to design and learn new APIs, and fosters software reuse" -- so say the Java 2 docs. From now on, says Sun, there's no reason to "roll your own."
However, while nearly all new APIs use some sort of collection, almost none use the Collections Framework. JDBC has a ResultSet; HttpServlet has an HttpSession; JNDI has a Context; JList and BeanInfo and Class and so forth return arrays of objects. None of these collections implement the framework interfaces.
This lack of implementation does not necessarily reflect a failure of the APIs themselves. It took a long time for the Collections team to finalize the APIs. Furthermore, the team decided to keep the framework as part of Java 2 and not to release the APIs early as a "standard extension." This meant that while the Collections Framework has been ready for action for the better part of a year, it has been difficult to integrate into other programs (suffering the same package naming confusion as Swing).
Sun is making a big marketing push for Java to become the standard in enterprise computing by being chosen as the development platform for companies creating reliable and high-performance distributed, database-driven, transaction-aware programs.
CORBA -- JavaIDL is now a core package, and Java 2 contains a pure Java ORB. That means any Java VM can act as a CORBA client or a CORBA server, and any Java object can become accessible through CORBA.
RMI -- You can now use custom sockets, sending RMI requests over SSL or IIOP. Also, a remote object can remain dormant until created by a client request.
Transactions -- Java 2 supports an implementation of the OMG/CORBA Object Transaction Service (OTS/JTS) with an alternate Java API on top (JTA). This allows a single transaction to comprise actions occurring on multiple VMs and multiple databases; all those actions will either succeed or fail as one.
JDBC -- Database access has been improved, with support for scrollable and updatable result sets, batch updates, connection pooling, rowsets (sort of a Bean-enabled database view), distributed transactions, extra data types, and so on.
Enterprise Java Beans -- While not technically part of the Java 2 release, EJB is a huge initiative coming out at basically the same time relying on the above enterprise features. EJB provides a common API for developing business components that live inside of Java application servers, provided by many different vendors. There are several organizations that can teach you more about EJBs, such as Purple Technology.
Java 2 represents a major advance in Java's security model, augmenting sandboxes with a much more subtle and capable system based on permissions and identity. Security in the VM is defined by the Policy, which provides a way to control the powers of pieces of code. The Java SecurityManager now delegates its work to the Policy object; the Policy, in turn, consults a policy file to decide whether sensitive operations are allowed. The Policy grants particular Permissions to the program based on a combination of where the code came from (the code base) and by whom the code was written (the code signature). Programmers can also extend the Permissions model by adding their own application-specific security checks.
Policies can be defined by editing a file or by using the new policytool application. The new security model allows for a great range of possibilities. For example, a user may decide to allow applets to save files to particular directories if they come from a trusted source. There is also more control over network-loaded code; this will be of particular interest to distributed Java efforts such as RMI and Jini.
Java 2 also expands support for cryptographic key management, including a keytool for managing key databases. Sun has also defined a Java Cryptographic Extension (JCE) to give an interface to public and private key encryption. Because of U.S. export restrictions, the JCE implementation will only be available from Sun in the U.S. and Canada; third-party implementations are being developed in other markets.
Although the new platform supports these security features, a user interface has yet to be integrated into the major browsers. Keytool offers no GUI interface for keytool and policytool, while graphical, may be somewhat intimidating for the non-developer.
Announcing the Java 2 Platform
Java Business Expo '98
The Swing Connection
JDK 1.2 Documentation on Security
Overview of Java security
Java Security Tutorial
[*1] Due to a bug, BoxLayout doesn't correctly align components to the left or right.
Alexander Day Chaffee is the CEO of Purple Technology and co-creator of Developer.com's sister site Gamelan.
Nelson Minar contributed research to this article.
This article was originally published on Thursday Dec 10th 1998
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monster at the end of the dream
A site dedicated to cinema—in its bleakest, most gruesome and viscerally glorious forms. put bluntly, we just want to recommend and discuss some (mostly) lesser-known titles to lovers of thrillers, crime and horror.
Good Times, Bad Cop: John Hawkes goes rogue in Small Town Crime (Netflix Instant) June 21, 2018
The Soaking Dead: Doom drops down in The Rain (Netflix streaming) May 16, 2018
Like Clockwork: Tom Hardy summons the ultraviolence in British gangster epic The Take (Amazon Prime) April 29, 2018
Revenge of the Nerd: The Gift on Netflix Instant March 24, 2018
True-ish detective: Unpacking “Manhunt: Unabomber” on Netflix streaming March 3, 2018
samfsadams on Unsung Gory: 26 lesser-known c…
Jason Hall on Good Times, Bad Cop: John Hawk…
Good Times, Bad Cop:… on A Walk Among the Tombstones: A…
Good Times, Bad Cop:… on Joe on Netflix Instant or: The…
Good Times, Bad Cop:… on In Bruges on Netflix Instant:…
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Scream n’ Stream 2016: Five Netflix Double-Features for Halloween
Before we get started, I need to air a grievance: Netflix really dropped the ball on modern horror this year. While Amazon Prime was adding instant classics like The Witch and Bone Tomahawk (and other really good stuff like Afflicted, Spring and Open Grave), Netflix basically added a few old classics, dropped half of the best horror in its catalogue, and then called it a day. Sure, there have been a couple bright spots in between (see: The Hallow, Hush, The Invitation), but it’s been a pretty disappointing year in blood spatter for the world’s most accessible and oft-used streaming service.
If you need further proof (as well as more recs beyond the 10 or so on this list) check out last year’s Scream n’ Stream post: 12 of those 22 flicks are gone. The good news is that Amazon Prime has been picking up a lot of the great stuff that Netflix dumped. If you are fortunate enough to have access to the Big 4 streaming services (including HBOGo and Hulu), check out this fantastic Halloween streaming calendar a blogger on Reddit put together.
All said, the pickins were slim this year when it came to Netflix. Especially as I didn’t want to include fare that everyone has already seen (see: The Babadook, Jaws, Children of the Corn, Hellraiser—which are all on there). Don’t worry though, I scowered the bowels and came up with a handful of thematically connected back-to-back features that should easily cover you this Halloween weekend.
So without further adieu, here’s this year’s witches brew…
Charlie’s Demons (Charlie Brooker horror)
For fans of Black Mirror, Charlie Brooker’s Dead Set is a stellar addition to the Netflix canon. It has all the wry, fatalistic wit and undertones of the hit series, but caters more directly to a horror audience. It’s also a great chance to see Brooker’s hellbent mind working in its primal infancy, shortly before Black Mirror made him a Lovecraft-level household name. I think the closest comparison here would be Zack Snyder’s fantastic Dawn of the Dead remake, as Dead Set revels in both the bloodlust of vicious, capable zombies while at the same time staying fiendishly tongue-in-cheek. It’s also a fun look at the early careers of future crime-series faces like Riz Ahmed (The Night Of), Warren Brown (Luther) and Andy Nyman (Peaky Blinders). Beyond that it’s just two and a half hours of viscerally engaging zombie goodness.
While I can’t say Playtest is my favorite episode from Black Mirror Season 3, it’s definitely not the worst. And in my humble opinion, an average episode of BM is better than a great episode of just about anything else on TV. Add the fact that it’s one of the few episodes in which BM ventures into the terrain of horror (the show is often horrific and bleak, but soul-crushing depression does not exactly a horror show make), and I’m even more hooked. This one features an American bro backpacking through Europe, only to meet a hot gamer chick on one of his last days in the UK. Strapped for cash, she directs him to a temp job that offers big cash to test a new VR videogame. A drive to an eerie mansion in the woods takes our man to a gaming experience borne straight out of hell. I will say that the lead is extremely fucking annoying, but some superb CGI and one mind-bending skullfuck of a narrative make this some damn good Halloween viewing. Playtest is also probably the greatest cinematic reminder ever of why sometimes you should just pick up the phone and call mom.
Dead Set
Presence in the Precinct House
Channeling the cult-classic Session 9, Last Shift brings us into the world of Jessica (Juliana Harkavy), a cop working her first shift. Of course she just happens to look like the half-sister of Jessica Alba and Hope Solo. Of course the shift is run alone. At night. In a precinct house that’s haunted by the spirit of a mass murder clan! Last Shift is one of those low-budget, sleeper Netflix horror titles that more than does the trick in terms of delivering continuous suspense and some good visual and psychological thrills. In fact, I’d go so far as to place it in the top ten horror movies of 2015. As a horror buff who is typically bored by paranormal films, this one easily kept my attention throughout. An impressive flick from up-and-coming horror director Anthony DiBlasi.
I’ll be frank: Baskin—which pits a group of Turkish cops against a netherworld of nightmarish evil in an abandoned precinct house—has very little in the way of a linear narrative or plot resolution. Trying to make sense of this movie is an exercise in futility, because the movie itself seems to have no interest in logic. All that said, the nightmarish visuals, incredible makeup and creative mindfuckery put this one in an otherworldly dream realm from hell—kind of like Hellraiser. This is the kind of horror flick I’d recommend if you either, a.) smoke the ganj, or b.) are stuck indoors this Halloween with a delirious headcold and are ingesting large amounts of cough syrup. It’s just a very strange movie with very strange visuals, and if you attempt to experience it more as a ride than as a plot-driven piece, there’s a lot of fun to be had here.
Last Shift
GRADE: B / B+
Damsels in Digital Distress
I know “found footage” is a pretty damn taboo subject among some horror fans, but between V/H/S/2, Afflicted, The Taking of Deborah Logan and a few others, I’ve been warming up to it over the past few years. The Den’s spin on the subgenre comes in the form of a webcam junkie (Melanie Papalia) who’s just received a university grant to do a study on a Facebook-meets-Skype web-chatting site called The Den (sorry, I’m too much of a luddite for a more specific comparison).
Her interactions with random strangers start innocently enough. Sure, there’s some pervs swinging their dicks around on the live site, but she also has some “meaningful interactions.” As she builds her data pool, an anonymous user starts sharing snuff films with her and hacking into her account. From here, her virtual reality and personal life merge as a living hell. There’s some corny acting and the typical horror cliche of inept authorities, but overall The Den brings a refreshing twist to the found-footage wave. And unlike many films in the subgenre and their supernaturally enigmatic endings, here we get some brutally chilling resolution.
Am I reaching to include Hush in a cyber-horror theme? Maybe. But a lot of this movie—based on a deaf woman dealing with a home invasion out in the woods—deals with our heroine doing everything she can to save herself via the powers of the iPhone. It’s also one of the best new horror movies Netflix added this year. It’s also a solid slasher flick in a genre that has seen a steep fall-off in production, what with every horror movie these days about a talking doll or haunted house. Netflix horror regulars will likely have seen this. The rest of the world probably hasn’t—a good enough reason for me to queue it up when folks are over this All Hallow’s Eve.
Sidenote: If you’re digging this cyber vibe, check out Black Mirror’s Shut Up and Dance—not horror, but arguably the best episode of Season 3.
50 Shades of Gangrene (Irish horror)
When I put together a list of some of best lesser-known modern horror flicks on Netflix, The Canal was my glaring omission. Perhaps I held off on watching it due to the corny cover art on Netflix that makes it look like a generic, direct-to-DVD snoozefest. In fact, this film is so good that I’m doubling back on my claim that The Babadook was the best horror film of 2014 (granted, it was a pretty shitty year for horror).
So what’s the deal with The Canal? Premise: An Irish film archivist moves his wife and son into a creepy old house located on a… canal, of all things. With a heavy tip o’ the cap to The Shining, our man starts losing his mind a wee bit, especially when he finds some films at work that reveal his house to be the scene of a century-old murder wherein a man killed his wife and kids.
This familiar narrative just described is pretty much where The Canal stops adhering to any genre conventions. I’ve stated on this blog that haunting movies generally don’t do the trick for me (just leave the fucking house, already!). But this one is more refreshing and palpable, if only because the majority of the film doesn’t take place in the house, and we don’t have to wade through an hour of creaking doors and power outages to get to the real meat. Moreover, The Canal operates on a heady, multilayered plain of psychological dementia that enters into a possessed mind in one of the most convincing—and therefore terrifying—ways I’ve encountered. Trippy, manic and skillfully crafted, the lack of recognition for director Ivan Kavanagh’s indie masterpiece is criminal. Queue it up without further delay.
As for The Hallow, it embraces traditional Irish folklore of banshees, faeries and evil bog creatures in what amounts to another surprisingly good slept-on, b-horror effort out of the Emerald Isle. Premise: An environmental conservationist moves his wife and newborn into a dusty, old brick mansion in the middle of the woods. Locals eye the newcomer with suspicion, warning him of ominous forces about the titular “hallow,” which he of course pays no heed to. One of the film’s strongest assets is how its cinematography plays off of the haunting Irish countryside, creating for an atmosphere of eerie, mystical gloom. There’s also some very strong acting, and not just via protagonist Joseph Mawle (whose lupine eyebrows alone may have you wetting your knickers). With a cast including Michael McElhatton (AKA Roose Bolton from Game of Thrones) and Michael Smiley (Kill List, Black Mirror, A Field in England) such catchphrases as, “This isn’t London—things here go bump in the night,” take on an air of menace that are as chilling as a midnight wade through a murky bog.
GRADE: B+ / A-
The Hallow
Don’t Drink the Kool-Aid!
Q: You know why no one ever makes Jonestown jokes?
A: The punch lines are too long…
OK, OK. Let me tell you why you should watch The Sacrament, a very thinly veiled “found-footage” recount of that time the homicidal megalomaniac zealot and pederast Jim Jones ritualistically killed off 900-plus people in a South American jungle. For starters, it’s directed by another cultish icon, the hallowed hipster-horror hero Ti West (The House of the Devil, V/H/S). Whether writing, directing or acting, Ti West has been involved in some of the past decade’s better horror showings (see also You’re Next) along with his plaid-clad homies Joe Swanberg, Simon Barrett and Adam Wingard. The Sacrament pits Swanberg as a Vice-esque journalist flying into an unknown jungle to research an ominous folk hero called Father (played by the great Gene Jones—no relation). From there, ominous undertones lead to all hell breaking loose in a suspense-packed 99 minutes of thrilling, if inherently predictable, damn-good horror.
I don’t really like to give away the genre of The Invitation, but seeing as this is a horror post I should let you know what this film is more “slow-burn suspense with deadly consequences” than it is all-out horror. However one would classify it, this take on the oft-visited “dinner party from hell” horror trope excels due to an expertly calculated level of psychological tension that courses through the entire otherwise-slow first hour of the film. I’m not going to outline the premise because, frankly, it would just take away from your viewing experience. Just know that it pairs well with The Sacrament.
GRADE: B+ / B
-Sam Adams
Tags Andy Nyman, Baskin, best halloween movies, best horror movies on netflix instant, Black Mirror, black mirror playtest, Bone Tomahawk, Charlie Brooker, Children of the Corn, dead set, gene jones, halloween movie playlist, Hellraiser, horror films, horror movies, hush horror, Jaws, Last Shift, Riz Ahmed, Sam Adams, scream n' stream, The Babadook, the den, the hallow, The Invitation, The Sacrament, The Witch, Ti West, Zack Snyder
Streaming Bleak This Week, #5: Cash Only on Netflix
A Georgian Film: Landmine Goes Click (on Amazon Prime)
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Home/Celebrity Net Worth/Actresses/Jill Duggar Net Worth
Jill Duggar Net Worth
Jill Duggar Net Worth 2021: Wiki Biography, Married, Family, Measurements, Height, Salary, Relationships
Jill Duggar net worth is
Jill Duggar Wiki Biography
Jill Michelle Duggar was born on the 17th May 1991, in Tontitown, Arkansas USA, and is a reality TV star who is probably best known for appearing in TLC’s reality TV shows “17 Kids and Counting”, as well as in “Jill & Jessa Counting On”.
Have you ever wondered how much wealth this young TV persona has accumulated so far? How rich Jill Duggar is? According to sources, it is estimated that the total of Jill Duggar’s net worth, as of late 2017, revolves around the sum of $400,000 which has been acquired largely through her on-camera appearances in various reality shows and TV documentaries.
Jill Duggar Net Worth $400,000
Jill is the fourth of 19 children of Michelle Annette and Jim Bob Duggar, and was raised in a devout Baptist manner, being homeschooled from an early age and being raised in modesty, without television, entertainment and various hi-tech commodities of the modern age. All of Jill’s 18 siblings – eight sisters and 10 brothers – have names which begin with the letter “J”. Her on-camera debut while she was still a teenage girl was in 2004, when she first appeared on TV screens in the movie “14 Children and Pregnant Again!” This engagement opened the doors for Jill Duggar’s future television engagements, which later provided the basis of her current net worth.
In 2006, Jill alongside her numerous family members starred in TV movies “16 Children and Moving In”, “Raising 16 Children” and “On the Road with 16 Children”. However, her real breakthrough came in 2008 when she began appearing in TLC’s reality TV series “17 Kids and Counting”. The show aired ’til 2015, subsequently changing titles to “18 Kids and Counting” and finally to “19 Kids and Counting” as the Duggar’s family was getting bigger. It is certain, that these appearances helped Jill Duggar to significantly boost the total of her wealth.
Apart from all those already mentioned above, Jill has also appeared in several other family-engaged adventures, including TV documentaries and movies “K1 Discovery” and “Duggar Makes a Movie”. She has also guest-starred in “Fox and Friends”, “The Kelly File” and “The Insider” TV series, in addition to appearing in “Larry King Live” and “Good Morning America” TV talk-shows. Jill’s most recent on-camera engagement includes TLC’s spin-off reality TV series entitled “Jill & Jessa Counting On”, which has been airing since 2015. Doubtlessly, all these accomplishments have helped Jill Duggar to dramatically increase the total size of her revenues.
Alongside four of her sisters, Jill has co-authored the book entitled “Growing Up Duggar: It’s All About Relationships”, which hit the bookstores in 2014, making a significant impact on her net worth too.
When it comes to the personal life of Jill Duggar, since 2014 she has been married to Derick Dillard, with whom she has welcomed two sons. Being a Certified Professional Midwife, alongside her husband, Jill spent ten months of 2015 as a missionary of S.O.S. Ministries in Central America. With her family, Jill currently resides in Rogers, Arkansas.
Full Name Jessa Seewald
Net Worth $400,000
Place Of Birth Tontitown, Arkansas, United States
Spouse Derick Dillard
Children Israel David Dillard, Samuel Scott Dillard
Parents Jim Bob Duggar, Michelle Duggar
Siblings Jessa Seewald, Jinger Duggar, Josh Duggar, Joy-Anna Duggar, Jana Duggar, Joseph Duggar, Josie Duggar, John-David Duggar, Josiah Duggar, Johannah Duggar, Jordyn-Grace Duggar, James Duggar, Jason Duggar, Jennifer Duggar, Justin Duggar, Jeremiah Duggar, Jedidiah Duggar, Jackson Duggar
Instagram https://www.instagram.com/jessaseewald/
IMDB http://www.imdb.com/name/nm2280248/
Movies Courageous
TV Shows 19 Kids and Counting, Jill and Jessa: Counting On
1 Gave birth to her 2nd child at age 24, a son on February 6, 2017. Child's father is her husband, Benjamin Seewald.
2 Gave birth to her 1st child at age 23, a son named Spurgeon Elliot Seewald on November 5, 2015. Child's father is her husband, Benjamin Seewald.
3 (November 1, 2014) Married her boyfriend of 14 months Benjamin Seewald following a 3-month-long engagement.
4 Aunt of Mackynzie Renee Duggar, Michael James Duggar, Marcus Anthony Duggar, Israel David Dillard & Meredith Grace Duggar.
5 Sister of Joshua Duggar, Jana Duggar, John-David Duggar, Jill Duggar, Jinger Duggar, Joseph Duggar, Josiah Duggar, Joy-Anna Duggar, Jedidiah Duggar, Jeremiah Duggar, Jason Duggar, James Duggar, Justin Duggar, Jackson Duggar, Johannah Duggar, Jennifer Duggar, Jordyn-Grace Makiya Duggar, and Josie Duggar.
6 Daughter of Michelle Duggar and Jim Bob Duggar.
17 Kids and Counting 2008-2009 TV Series documentary additional photography - 2 episodes
Courageous 2011 Girl at Funeral
Jill & Jessa Counting On 2015-2016 TV Series Herself
The 5 Day Adoption 2016 Documentary
Good Morning America 2014-2016 TV Series Herself
The Insider 2016 TV Series Herself
Breaking the Silence 2015 TV Movie documentary Herself
The Kelly File 2015 TV Series Herself
17 Kids and Counting 2008-2014 TV Series documentary Herself
Today 2007-2013 TV Series Herself
Duggars Make a Movie 2010 TV Movie Herself
Larry King Live 2009 TV Series Herself
Duggars' Big Family Album 2008 TV Movie documentary Herself
K1 Discovery 2007 TV Series documentary Herself
On the Road with 16 Children 2006 TV Movie Herself
Raising 16 Children 2006 TV Movie Herself
16 Children and Moving In 2006 TV Movie documentary Herself
14 Children and Pregnant Again! 2004 TV Movie Herself
Inside Edition 2015 TV Series documentary Herself
Entertainment Tonight 2015 TV Series Herself
Media Buzz 2015 TV Series Herself
Chelsea Lately 2013 TV Series Herself
17 Kids and Counting (2008-2014)
as Camera and Electrical Department
Today (2007-2013)
as Herself
16 Children and Moving In (2006)
14 Children and Pregnant Again! (2004)
$400 $400000 000 1.65 m 1991 1991-05-17 Actress American Arkansas Derick Dillard Israel David Dillard Jackson Duggar James Duggar Jana Duggar Jason Duggar Jedidiah Duggar Jennifer Duggar Jeremiah Duggar Jessa Seewald Jill Duggar Jim Bob Duggar Jinger Duggar Johannah Duggar John-David Duggar Jordyn-Grace Duggar Joseph Duggar Josh Duggar Josiah Duggar Josie Duggar Joy-Anna Duggar Justin Duggar May 17 Michelle Duggar Samuel Scott Dillard Tontitown United States
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Naomi Campbell Net Worth
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Mitt Romney’s Newest “Hardship”: Mom-And-Pop Bain Capital
Mitt Romney casts himself as a small-business owner on the stump in Florida.
Mitt Romney just can’t drop his phony everyman act, and he added a new spin on it Friday night: the struggling young businessman.
By this point anyone with even the slightest interest in politics is well aware of Romney’s extreme wealth. Criticism from his rivals finally forced Romney to enter his most recent tax returns into the public record, and the figures were astounding. He earned $21.7 million in 2010; he earns the average median household income in less than a single day.
Yet he continues to uncomfortably wear his regular-guy jeans over his Brooks Brothers suits, trying his hardest to convince voters that he can relate to their economic woes. When he was here in Florida last year he told a group of voters that he was also unemployed and, in New Hampshire, the Harvard MBA/JD said he had also had moments where he was concerned about getting a pink slip
Romney included a new narrative of hardship at a rally hosted inside a pant factory plant in Orlando on Friday night. He began by railing against the government before discussing the early parts of his career as a vulture venture capitalist:
“Let me tell you the difference between what happens in the real economy—the private sector—and when government is practicing crony capitalism, playing by their own set of rules. You see, when we first helped Staples (the office superstore) get started, we raised about $5 or $10 million, to get that first store going. The government put in $500 million into Solyndra. And our offices, by the way, were in the back of a shopping center, an abandoned shopping center. We had all old furniture. I remember these chairs we had for the board meetings; they were these mahogany hide chairs. We sunk so deeply you had to have an athletic body to get out of them.”
That must have only seemed like roughing it compared to the throne Romney sat on at Bain Capital. When consulting firm Bain & Company tasked Romney with spinning off a new private equity venture in 1983, he raised $37 million in funds to launch the new group the next year, hardly the type of budget to describe a group meeting in back alleys and sitting on leftover furniture purchased from Goodwill.
It’s mystifying why Romney continues to push this persona. America loves the idea of a self-made millionaire, and while that’s a bit of a hard sell given his father’s prominence in business and politics, it’s surely closer to reality than his current guise of a typical suburban small business owner.
By: Patrick Caldwell, The American Prospect, January 28, 2012
January 29, 2012 - Posted by raemd95 | Election 2012, GOP Presidential Candidates | Bain Capital, Florida, GOP, Mitt Romney, Politics, Republicans, Venture Capitalism
[…] Mitt Romney’s Newest “Hardship”: Mom-And-Pop Bain Capital (mykeystrokes.com) […]
Pingback by The Two Faces Of Mitt Romney | The Rise of ROMDROID « The Age of Blasphemy | January 30, 2012 | Reply
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“The Face Of The McConnell Campaign”: Should Chuck Todd Be ‘Disqualified’ For Saying The Midterm Elections Don’t Matter?
A few developments today in the all-important Kentucky Senate race: Bill Clinton is expected to draw large, enthusiastic crowds for Alison Lundergan Grimes in Owensboro and Paducah; Mitch McConnell is on day two of his three-day fake-enthusiasm bus tour (the state GOP party is giving all-expenses-paid trips to volunteers as long as they “contribute to an enthusiastic atmosphere” at his events, according to an e-mail obtained by The Hill); and Chuck Todd continues to defend his now-infamous declaration that Grimes “disqualified herself” by refusing to say whether she voted for Obama.
As you’ve probably seen by now, McConnell put footage of Todd in a heavily rotated TV ad, and, from what I could tell after spending two days in Kentucky, Chuck Todd has become the face of the McConnell campaign.
Now, I don’t know if this exactly disqualifies Todd from moderating the New Hampshire debate tonight between Jeanne Shaheen and Scott Brown, but the host of the storied Meet the Press and a self-described political junkie has said that it really doesn’t matter which political party wins the Senate. He made that case in an interview with President Obama on his debut MTP last month, saying, A couple more extra red or a couple more blue seats, what’s the diff? Three billion dollars, he said, is being spent merely “to see if it’s Harry Reid or Mitch McConnell that’s in charge of gridlock in the Senate.”
Todd then turned to panelist John Stanton, from Buzzfeed, to pooh-pooh Obama’s argument that party control of the Senate is actually, uh, important:
TODD: You know, Stanton, he was trying to make the rationale for why the midterms matter. And when you have to say, “I know some people don’t think, but they really do matter.”
JOHN STANTON: You’ve already lost…..
in terms of legislation passing. If Democrats keep the Senate, and they have, what, a two-seat or a one-seat majority, or if Republicans take it and have a two-seat or one-seat majority, you still are left with essentially the same dynamic in Washington.
But surely Todd, if not also Stanton, knows that even if no legislation passes (presumably the Dems would filibuster and Obama would veto GOP bills), a McConnell-led Senate would still affect the lives of millions of people. A one- or two-seat majority would give Republicans all the committee chairmanships, and that, as Norm Ornstein writes, “would undoubtedly stop confirmation on virtually all Obama-nominated judges, and probably on most of his executive nominees. And we would see a sharp ramp-up of investigations of alleged wrongdoing, with Benghazi and IRS redux. If you like Darrell Issa, you will love having his reinforcements and doppelgängers in the other chamber.”
Even Politico says, “No one should underestimate the significance if the GOP captures the Senate in November…”
Mitch McConnell, who would become majority leader if the Senate changes hands, is already promising to load up the appropriations bills with policy restrictions that could raise the risk of another government shutdown if Obama doesn’t sign them.
With both the Senate and the House in their hands, Republicans could put Obama on defense on everything from Obamacare to the administration’s greenhouse gas regulations, the Keystone XL pipeline, education policy and spending priorities.
And even with gridlock, McConnell could reach his dream of repealing Obamacare “root and branch.” Robert Reich warns in a MoveOn video that the R’s could use the Senate maneuver of “reconciliation,” which requires “only 51 votes to pass major tax and budget legislation instead of the 60 votes usually required.” That means, he says, that Republicans could win tax cuts for the wealthy and loopholes for Wall Street and pay for them with cuts in Medicare, Medicaid and education. (The Dems used reconciliation to pass the Affordable Care Act in the first place.)
But issues that matter to real people often evaporate in the heat generated by horse-race pundits like Todd. Grimes is “disqualified” for not answering a question (“By dodging the question, did she cast a spell on herself that reverse-aged her to be ineligible for service in the U.S. Senate?” Jim Newell at Salon asks. “Did her incantation strike names from her ballot petitions, putting her below the threshold to qualify for ballot placement?”). But McConnell lies by claiming he can repeal Obamacare while letting Kentuckians keep their Kynect—without acknowledging that Kynect is Obamacare.
As The Nation’s Reed Richardson writes: “When confronted about his specious reasoning in a subsequent Facebook Q & A, Todd backed off his judgment a bit (‘disqualifying for some voters’ was his new formulation), but still defended his over-the-top analysis as reflecting ‘political reality.’ But for all his cynicism, Todd still tries to have it both ways. For, later in the same Facebook chat he said he was ‘sick’ over the fact the McConnell camp had already stuck his Grimes-bashing soundbite into a campaign ad.”
Todd goes into still longer explanations with Media Matters, saying his wording was “sloppy.” It seems like his judgment that it doesn’t matter who runs the Senate was, at best, sloppy, too.
By: Leslie Savan, The Nation, October 21, 2014
October 24, 2014 - Posted by raemd95 | Chuck Todd, Midterm Elections, Mitch Mc Connell | Alison Lundergan Grimes, GOP, Government Shutdown, John Stanton, Kentucky Senate Race, Republicans
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CVSS Version 2
Warning: The information supplied in the URL does not match the information in the NVD. NVD CVSS vectors have been displayed instead for the CVE-ID provided.
Common Vulnerability Scoring System Calculator CVE-2020-15989
Source: NIST
This page shows the components of the CVSS score for example and allows you to refine the CVSS base score. Please read the CVSS standards guide to fully understand how to score CVSS vulnerabilities and to interpret CVSS scores. The scores are computed in sequence such that the Base Score is used to calculate the Temporal Score and the Temporal Score is used to calculate the Environmental Score.
Please fill in all base score metrics in order to generate a score!
CVSS Base Score:
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Impact Subscore:
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Exploitability Subscore:
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CVSS Temporal Score:
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CVSS Environmental Score:
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Modified Impact Subscore:
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Overall CVSS Score:
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Show Equations
CVSS v2 Vector
Base Score Metrics
Exploitability Metrics
Access Vector (AV)*
Local (AV:L)
Adjacent Network (AV:A)
Network (AV:N)
Access Complexity (AC)*
High (AC:H)
Medium (AC:M)
Low (AC:L)
Authentication (Au)*
Multiple (Au:M)
Single (Au:S)
None (Au:N)
Impact Metrics
Confidentiality Impact (C)*
None (C:N)
Partial (C:P)
Complete (C:C)
Integrity Impact (I)*
None (I:N)
Partial (I:P)
Complete (I:C)
Availability Impact (A)*
None (A:N)
Partial (A:P)
Complete (A:C)
Temporal Score Metrics
Exploitability (E)
Not Defined (E:ND)
Unproven that exploit exists (E:U)
Proof of concept code (E:POC)
Functional exploit exists (E:F)
High (E:H)
Remediation Level (RL)
Not Defined (RL:ND)
Official fix (RL:OF)
Temporary fix (RL:TF)
Workaround (RL:W)
Unavailable (RL:U)
Report Confidence (RC)
Not Defined (RC:ND)
Unconfirmed (RC:UC)
Uncorroborated (RC:UR)
Confirmed (RC:C)
Environmental Score Metrics
General Modifiers
Collateral Damage Potential (CDP)
Not Defined (CDP:ND)
None (CDP:N)
Low (light loss) (CDP:L)
Low-Medium (CDP:LM)
Medium-High (CDP:MH)
High (catastrophic loss) (CDP:H)
Target Distribution (TD)
Not Defined (TD:ND)
None [0%] (TD:N)
Low [0-25%] (TD:L)
Medium [26-75%] (TD:M)
High [76-100%] (TD:H)
Impact Subscore Modifiers
Confidentiality Requirement (CR)
Not Defined (CR:ND)
Low (CR:L)
Medium (CR:M)
High (CR:H)
Integrity Requirement (IR)
Not Defined (IR:ND)
Low (IR:L)
Medium (IR:M)
High (IR:H)
Availability Requirement (AR)
Not Defined (AR:ND)
Low (AR:L)
Medium (AR:M)
High (AR:H)
The base metric group captures the characteristics of a vulnerability that are constant with time and across user environments. The Access Vector, Access Complexity, and Authentication metrics capture how the vulnerability is accessed and whether or not extra conditions are required to exploit it. The three impact metrics measure how a vulnerability, if exploited, will directly affect an IT asset, where the impacts are independently defined as the degree of loss of confidentiality, integrity, and availability. For example, a vulnerability could cause a partial loss of integrity and availability, but no loss of confidentiality.
This metric reflects how the vulnerability is exploited. The more remote an attacker can be to attack a host, the greater the vulnerability score.
A vulnerability exploitable with only local access requires the attacker to have either physical access to the vulnerable system or a local (shell) account. Examples of locally exploitable vulnerabilities are peripheral attacks such as Firewire/USB DMA attacks, and local privilege escalations (e.g., sudo).
A vulnerability exploitable with adjacent network access requires the attacker to have access to either the broadcast or collision domain of the vulnerable software. Examples of local networks include local IP subnet, Bluetooth, IEEE 802.11, and local Ethernet segment.
A vulnerability exploitable with network access means the vulnerable software is bound to the network stack and the attacker does not require local network access or local access. Such a vulnerability is often termed “remotely exploitable”. An example of a network attack is an RPC buffer overflow.
This metric measures the complexity of the attack required to exploit the vulnerability once an attacker has gained access to the target system. For example, consider a buffer overflow in an Internet service: once the target system is located, the attacker can launch an exploit at will.
Other vulnerabilities, however, may require additional steps in order to be exploited. For example, a vulnerability in an email client is only exploited after the user downloads and opens a tainted attachment. The lower the required complexity, the higher the vulnerability score.
Specialized access conditions exist. For example, in most configurations, the attacking party must already have elevated privileges or spoof additional systems in addition to the attacking system (e.g., DNS hijacking). The attack depends on social engineering methods that would be easily detected by knowledgeable people. For example, the victim must perform several suspicious or atypical actions. The vulnerable configuration is seen very rarely in practice. If a race condition exists, the window is very narrow.
The access conditions are somewhat specialized; the following are examples: The attacking party is limited to a group of systems or users at some level of authorization, possibly untrusted. Some information must be gathered before a successful attack can be launched. The affected configuration is non-default, and is not commonly configured (e.g., a vulnerability present when a server performs user account authentication via a specific scheme, but not present for another authentication scheme). The attack requires a small amount of social engineering that might occasionally fool cautious users (e.g., phishing attacks that modify a web browser’s status bar to show a false link, having to be on someone’s “buddy” list before sending an IM exploit).
Specialized access conditions or extenuating circumstances do not exist. The following are examples: The affected product typically requires access to a wide range of systems and users, possibly anonymous and untrusted (e.g., Internet-facing web or mail server). The affected configuration is default or ubiquitous. The attack can be performed manually and requires little skill or additional information gathering. The 'race condition' is a lazy one (i.e., it is technically a race but easily winnable).
This metric measures the number of times an attacker must authenticate to a target in order to exploit a vulnerability. This metric does not gauge the strength or complexity of the authentication process, only that an attacker is required to provide credentials before an exploit may occur. The possible values for this metric are listed in Table 3. The fewer authentication instances that are required, the higher the vulnerability score.
It is important to note that the Authentication metric is different from Access Vector. Here, authentication requirements are considered once the system has already been accessed. Specifically, for locally exploitable vulnerabilities, this metric should only be set to 'single' or 'multiple' if authentication is needed beyond what is required to log into the system. An example of a locally exploitable vulnerability that requires authentication is one affecting a database engine listening on a Unix domain socket (or some other non-network interface). If the user must authenticate as a valid database user in order to exploit the vulnerability, then this metric should be set to 'single.'
Exploiting the vulnerability requires that the attacker authenticate two or more times, even if the same credentials are used each time. An example is an attacker authenticating to an operating system in addition to providing credentials to access an application hosted on that system.
One instance of authentication is required to access and exploit the vulnerability.
Authentication is not required to access and exploit the vulnerability.
Confidentiality Impact (C)
This metric measures the impact on confidentiality of a successfully exploited vulnerability. Confidentiality refers to limiting information access and disclosure to only authorized users, as well as preventing access by, or disclosure to, unauthorized ones. Increased confidentiality impact increases the vulnerability score.
There is no impact to the confidentiality of the system.
There is considerable informational disclosure. Access to some system files is possible, but the attacker does not have control over what is obtained, or the scope of the loss is constrained. An example is a vulnerability that divulges only certain tables in a database.
There is total information disclosure, resulting in all system files being revealed. The attacker is able to read all of the system's data (memory, files, etc.).
Integrity Impact (I)
This metric measures the impact to integrity of a successfully exploited vulnerability. Integrity refers to the trustworthiness and guaranteed veracity of information. Increased integrity impact increases the vulnerability score.
There is no impact to the integrity of the system.
Modification of some system files or information is possible, but the attacker does not have control over what can be modified, or the scope of what the attacker can affect is limited. For example, system or application files may be overwritten or modified, but either the attacker has no control over which files are affected or the attacker can modify files within only a limited context or scope.
There is a total compromise of system integrity. There is a complete loss of system protection, resulting in the entire system being compromised. The attacker is able to modify any files on the target system.
Availability Impact (A)
This metric measures the impact to availability of a successfully exploited vulnerability. Availability refers to the accessibility of information resources. Attacks that consume network bandwidth, processor cycles, or disk space all impact the availability of a system. Increased availability impact increases the vulnerability score.
There is no impact to the availability of the system.
There is reduced performance or interruptions in resource availability. An example is a network-based flood attack that permits a limited number of successful connections to an Internet service.
There is a total shutdown of the affected resource. The attacker can render the resource completely unavailable.
The threat posed by a vulnerability may change over time. Three such factors that CVSS captures are: confirmation of the technical details of a vulnerability, the remediation status of the vulnerability, and the availability of exploit code or techniques. Since temporal metrics are optional they each include a metric value that has no effect on the score. This value is used when the user feels the particular metric does not apply and wishes to "skip over" it.
This metric measures the current state of exploit techniques or code availability. Public availability of easy-to-use exploit code increases the number of potential attackers by including those who are unskilled, thereby increasing the severity of the vulnerability.
Initially, real-world exploitation may only be theoretical. Publication of proof of concept code, functional exploit code, or sufficient technical details necessary to exploit the vulnerability may follow. Furthermore, the exploit code available may progress from a proof-of-concept demonstration to exploit code that is successful in exploiting the vulnerability consistently. In severe cases, it may be delivered as the payload of a network-based worm or virus. The more easily a vulnerability can be exploited, the higher the vulnerability score.
Assigning this value to the metric will not influence the score. It is a signal to the equation to skip this metric.
No exploit code is available, or an exploit is entirely theoretical.
Proof-of-concept exploit code or an attack demonstration that is not practical for most systems is available. The code or technique is not functional in all situations and may require substantial modification by a skilled attacker.
Functional exploit code is available. The code works in most situations where the vulnerability exists.
Either the vulnerability is exploitable by functional mobile autonomous code, or no exploit is required (manual trigger) and details are widely available. The code works in every situation, or is actively being delivered via a mobile autonomous agent (such as a worm or virus).
The remediation level of a vulnerability is an important factor for prioritization. The typical vulnerability is unpatched when initially published. Workarounds or hotfixes may offer interim remediation until an official patch or upgrade is issued. Each of these respective stages adjusts the temporal score downwards, reflecting the decreasing urgency as remediation becomes final. The less official and permanent a fix, the higher the vulnerability score is.
A complete vendor solution is available. Either the vendor has issued an official patch, or an upgrade is available.
There is an official but temporary fix available. This includes instances where the vendor issues a temporary hotfix, tool, or workaround.
There is an unofficial, non-vendor solution available. In some cases, users of the affected technology will create a patch of their own or provide steps to work around or otherwise mitigate the vulnerability.
There is either no solution available or it is impossible to apply.
This metric measures the degree of confidence in the existence of the vulnerability and the credibility of the known technical details. Sometimes, only the existence of vulnerabilities are publicized, but without specific details. The vulnerability may later be corroborated and then confirmed through acknowledgement by the author or vendor of the affected technology. The urgency of a vulnerability is higher when a vulnerability is known to exist with certainty. This metric also suggests the level of technical knowledge available to would-be attackers. The more a vulnerability is validated by the vendor or other reputable sources, the higher the score.
There is a single unconfirmed source or possibly multiple conflicting reports. There is little confidence in the validity of the reports. An example is a rumor that surfaces from the hacker underground.
There are multiple non-official sources, possibly including independent security companies or research organizations. At this point there may be conflicting technical details or some other lingering ambiguity.
The vulnerability has been acknowledged by the vendor or author of the affected technology. The vulnerability may also be "Confirmed: when its existence is confirmed from an external event such as publication of functional or proof-ofconcept exploit code or widespread exploitation.
Different environments can have an immense bearing on the risk that a vulnerability poses to an organization and its stakeholders. The CVSS environmental metric group captures the characteristics of a vulnerability that are associated with a user's IT environment. Since environmental metrics are optional they each include a metric value that has no effect on the score. This value is used when the user feels the particular metric does not apply and wishes to 'skip over' it.
This metric measures the potential for loss of life or physical assets through damage or theft of property or equipment. The metric may also measure economic loss of productivity or revenue. Naturally, the greater the damage potential, the higher the vulnerability score.
There is no potential for loss of life, physical assets, productivity or revenue.
A successful exploit of this vulnerability may result in slight physical or property damage. Or, there may be a slight loss of revenue or productivity to the organization.
A successful exploit of this vulnerability may result in moderate physical or property damage. Or, there may be a moderate loss of revenue or productivity to the organization.
A successful exploit of this vulnerability may result in significant physical or property damage or loss. Or, there may be a significant loss of revenue or productivity.
A successful exploit of this vulnerability may result in catastrophic physical or property damage and loss. Or, there may be a catastrophic loss of revenue or productivity.
This metric measures the proportion of vulnerable systems. It is meant as an environment-specific indicator in order to approximate the percentage of systems that could be affected by the vulnerability. The possible values for this metric are listed in Table 11. The greater the proportion of vulnerable systems, the higher the score.
No target systems exist, or targets are so highly specialized that they only exist in a laboratory setting. Effectively 0% of the environment is at risk.
Targets exist inside the environment, but on a small scale. Between 1% - 25% of the total environment is at risk.
Targets exist inside the environment, but on a medium scale. Between 26% - 75% of the total environment is at risk.
Targets exist inside the environment on a considerable scale. Between 76% - 100% of the total environment is considered at risk.
These metrics enable the analyst to customize the CVSS score depending on the importance of the affected IT asset to a user’s organization, measured in terms of confidentiality, integrity, and availability, That is, if an IT asset supports a business function for which availability is most important, the analyst can assign a greater value to availability, relative to confidentiality and integrity. Each security requirement has three possible values: low, medium, or high.
Loss of Confidentiality is likely to have only a limited adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of Confidentiality is likely to have a serious adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of Confidentiality is likely to have a catastrophic adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of Integrity is likely to have only a limited adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of Integrity is likely to have a serious adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of Integrity is likely to have a catastrophic adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of availability is likely to have only a limited adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of availability is likely to have a serious adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
Loss of availability is likely to have a catastrophic adverse effect on the organization or individuals associated with the organization (e.g., employees, customers).
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少女時代、ベストAL収録曲のキャッチコピーを一般募集！優秀作品は新聞に掲載
7月23日（水）にリリースを控えた少女時代初のベストアルバム『THE BEST』の発売を祝して、同作収録楽曲のキャッチコピーを一般募集するという企画が行われている。
『THE BEST』に収録されるのは、衝撃的な日本デビューを飾った「GENIE」、PVでメンバーが着用したスキニーが爆発的に売れ大量のダンスコピー映像がYouTubeに投下された「Gee」、少女時代の名をお茶の間にまで広めた「MR.TAXI」といった名曲を含む計14曲。これら収録曲の中から好きな曲を選び、キャッチコピーを付けてTwitterやFacebookで投稿するというのが今回の企画の主旨であり、優秀作に選ばれたコピーは7月末の朝日新聞全段広告に名前入りで掲載されるとのことだ。「少女時代の魅力を自分の言葉で人に伝えたい！」というファンはもとより、コピーセンスに自信のあるクリエーター志望者から音楽ファン、一般SNSユーザーまで幅広い層に対して、ユニークでセンスのあるコピーを広く募集中。詳細はオフィシャル・サイトにて。
なお、少女時代はオフィシャルTwitterアカウントを新たに開設しており、最新情報を随時発信中。ツアーの模様やプロモーション情報といった鮮度の高い情報がこちらでチェックできる。
・少女時代 オフィシャル・サイト
http://www.girls-generation.jp/
・少女時代 オフィシャルTwitter
https://twitter.com/gg_official_jp
少女時代、7月発売のベスト・アルバム詳細を解禁！
少女時代、自身最多の20万人動員する全国アリーナ・ツアーをスタート！
少女時代史上初！ 超プレミアムなライブハウス・イベントが開催決定！
FIFAワールドカップ2014ベストショット【フォト集】
Argentina's Lionel Messi celebrates scoring his side's second goal during the group F World Cup soccer match between Argentina and Bosnia at the Maracana Stadium in Rio de Janeiro, Brazil, Sunday, June 15, 2014. (AP Photo/Victor R. Caivano)
Portugal fans pose prior to the Group G football match between Germany and Portugal at the Fonte Nova Arena in Salvador during the 2014 FIFA World Cup on June 16, 2014. (DIMITAR DILKOFF/AFP/Getty Images)
Fireworks are displayed over Lebanese soccer fans who have gathered to watch the first soccer match of the World Cup between Brazil and Croatia, at a fan park in downtown Beirut, Lebanon, Thursday June 12, 2014. (AP Photo/Hussein Malla)
Hugo Almeida of Portugal and Mats Hummels of Germany battle for the ball during the 2014 FIFA World Cup Brazil Group G match between Germany and Portugal at Arena Fonte Nova on June 16, 2014 in Salvador, Brazil. (Photo by Francois Xavier Marit - Pool/Getty Images)
A general view of the stadium during the 2014 FIFA World Cup Brazil Group F match between Argentina and Bosnia-Herzegovina at Maracana on June 15, 2014 in Rio de Janeiro, Brazil. (Photo by Clive Rose/Getty Images)
US soccer fans attend the FIFA Fan Fest in Natal at Fan HQ on June 15, 2014 in Natal, Brazil. (Photo by Kevin C. Cox/Getty Images)
Germany fans celebrate during a public viewing at Heiligengeistfeld watching the 2014 FIFA World Cup match between Germany and Portugal on June 16, 2014 in Hamburg, Germany. (Photo by Joern Pollex/Bongarts/Getty Images)
Fans arrive for the Group F match between Argentina and Bosnia-Herzegovina during the 2014 FIFA World Cup at Maracana on June 15, 2014 in Rio de Janeiro, Brazil. (Photo by Alexandre Loureiro/Getty Images)
A general view as England train during a training session at the Urca military base (Forte de Urca) training ground at on June 16, 2014 in Rio de Janeiro, Brazil. (Photo by Richard Heathcote/Getty Images)
German and other soccer fans create a conga line while waiting for the start of the German vs. Portugal match as they watch on a giant screen at the FIFA World Cup Fan Fest on Copacabana beach on June 16, 2014 in Rio de Janeiro, Brazil. The teams are playing on the fifth day of the World Cup tournament. (Photo by Joe Raedle/Getty Images)
A Colombia fan shows support prior to the 2014 FIFA World Cup Brazil Group C match between Colombia and Greece at Estadio Mineirao on June 14, 2014 in Belo Horizonte, Brazil. (Photo by Paul Gilham/Getty Images)
Military Police block anti-World Cup protestors attempting to march to Maracana stadium on June 15, 2014 in Rio de Janeiro, Brazil. Today is the fourth day of the 2014 FIFA World Cup. (Photo by Mario Tama/Getty Images)
A general view as the crowd watches the action during the 2014 FIFA World Cup Brazil Group D match between England and Italy at Arena Amazonia on June 14, 2014 in Manaus, Brazil. (Photo by Francois Xavier Marit - Pool/Getty Images)
A boy plays with a football as the Netherlands and Spain play FIFA World Cup 2014 football match, at the Rocinha shantytown in Rio de Janeiro, Brazil, on June 13, 2014. (AFP PHOTO / YASUYOSHI CHIBA)
A Uruguayan national football team fan watches the FIFA World Cup match against Costa Rica on a giant screen in Montevideo on June 14, 2014. (AFP PHOTO/Miguel Rojo)
A pickup truck with Argentine football fans drive past riot police trying to control the fans and keep them from impeding vehicle traffic as they show their enthusiasm for their team playing in the FIFA World Cup on June 14, 2014 in Rio de Janeiro, Brazil. The Argentine team plays their first match tomorrow against Bosnia and Herzegovina. (Photo by Joe Raedle/Getty Images)
Andrea Pirlo of Italy walks into the pitch followed by Salvatore Sirigu and Giorgio Chiellini before the 2014 FIFA World Cup Brazil Group D match between England and Italy at Arena Amazonia on June 14, 2014 in Manaus, Brazil. (Photo by Christopher Lee/Getty Images)
England's forward Daniel Sturridge celebrates after scoring during a Group D football match between England and Italy at the Amazonia Arena in Manaus during the 2014 FIFA World Cup on June 14, 2014. (FRANCOIS XAVIER MARIT/AFP/Getty Images)
An England supporter reacts in the Walkabout bar in central London on June 14, 2014, after England scored an equalising goal during their first Group D match against Italy in the 2014 FIFA World Cup in Brazil. (JUSTIN TALLIS/AFP/Getty Images)
A pole dancer performs as Japanese football fans cheer during a football-themed evening at a club in Tokyo on June 14, 2014, on the day of Japan's first game in the FIFA World Cup in Brazil. Japan will play against Ivory Coast in the first round match of the group C of the FIFA World Cup. (YOSHIKAZU TSUNO/AFP/Getty Images)
A taxi driver watches Uruguay and Costa Rica play on his small television set as the FIFA World Cup continues on June 14, 2014 in Rio de Janeiro, Brazil. The match was played on the third day of the World Cup tournament. (Photo by Joe Raedle/Getty Images)
Riot police face protesters in the vicinity of the FIFA Fan Fest in Copacabana Beach in Rio de Janeiro, Brazil on June 12, 2014. Brazil's ambivalence toward the World Cup was on full display as the country geared up for the game, the sea of green and yellow in some areas contrasting with the billowing smoke from burning garbage and clouds of tear gas that filled the air as military police and protesters clashed in the nation's financial hub. (YASUYOSHI CHIBA/AFP/Getty Images)
General view of the Beira-Rio Stadium at the start of the Group E football match between France and Honduras in Porto Alegre during the 2014 FIFA World Cup on June 15, 2014. (LUIS ACOSTA/AFP/Getty Images)
Brazilian soldiers take position in a street next to The Arena Amazonia in Manaus on June 14, 1014, ahead of the England v Italy match of the 2014 FIFA World Cup. (FABRICE COFFRINI/AFP/Getty Images)
The shadows of Chile soccer fans are cast on a fence outside the Arena Pantanal as they arrive to their team's World Cup match with Australia in Cuiaba, Brazil, Friday, June 13, 2014. (AP Photo/Felipe Dana)
An elderly woman smiles as a volunteer shows her cheek after painting a Brazilian national flag as she arrives to watch Nigerian team's open training session in Campinas, on June 13, 2014 during the 2014 FIFA World Cup tournament in Brazil. (JEWEL SAMAD/AFP/Getty Images)
Inter Campus & SAP Brazil Football Project on June 14, 2014 in Favela Vila dos Pinheiros, Rio de Janeiro, Brazil. (Photo by Raphael Dias/Getty Images for SAP)
Young residents gather red paint on their hands, symoblizing the blood of Mare residents killed, where protestors painted a street with the phrase 'Cup for Whom?' in the Mare community, or 'favela', on June 14, 2014 in Sao Paulo, Brazil. The favela is currently occupied by the Brazilian Army. A recent Pew Research poll stated 61 percent of Brazilians believe hosting the World Cup is negative for Brazil. Anti-World Cup protestors feel the Cup will take away money away from health care, education and other public services. (Photo by Mario Tama/Getty Images)
A resident walks past Brazilian flag in a favella area next to The Arena Amazonia in Manaus on June 14, 1014, ahead of the England v Italy match of the 2014 FIFA World Cup. (FABRICE COFFRINI/AFP/Getty Images)
Young local boys play football in the street prior to the 2014 FIFA World Cup Brazil Group D match between England and Italy at Arena Amazonia on June 14, 2014 in Manaus, Brazil. (Photo by Warren Little/Getty Images)
Argentina's fans cheer for their team during the Group F football match between Argentina and Bosnia Hercegovina at the Maracana Stadium in Rio De Janeiro during the 2014 FIFA World Cup on June 15, 2014. (DAMIEN MEYER/AFP/Getty Images)
American soccer fan Phillip Amador from Las Cruces rides the subway as he waits for the USA to play in the FIFA World Cup on June 15, 2014 in Rio de Janeiro, Brazil. His team is playing tomorrow against Ghana. (Photo by Joe Raedle/Getty Images)
A Brazilian Satere-Mawe indigenous man waits to watch the FIFA World Cup inaugural match between Brazil and Croatia, on June 12, 2014 in Manaus, Amazonas state, Brazil. (RAPHAEL ALVES/AFP/Getty Images)
A general view of training during a Costa Rica training session at Castelao on June 13, 2014 in Fortaleza, Brazil. (Photo by Jamie McDonald/Getty Images)
A general view taken with a fish eye lens shows the Amazonia Arena in Manaus during a Group D football match against England at during the 2014 FIFA World Cup on June 14, 2014. AFP PHOTO / FRANCOIS XAVIER MARIT
Japan fans hold a flag and cheer during the 2014 FIFA World Cup Brazil Group C match between the Ivory Coast and Japan at Arena Pernambuco on June 14, 2014 in Recife, Brazil. (Photo by Jamie Squire/Getty Images)
Artists perform during the Opening Ceremony of the 2014 FIFA World Cup Brazil prior to the Group A match between Brazil and Croatia at Arena de Sao Paulo on June 12, 2014 in Sao Paulo, Brazil. (Photo by Adam Pretty/Getty Images)
A worker at a pizza store celebrates in San Jose after Costa Rica defeated Uruguay in the FIFA World Cup Brazil Group D match on June 14, 2014. (EZEQUIEL BECERRA/AFP/Getty Images)
Costa Ricans celebrate their victory over Uruguay at the FIFA Fan Fest on Copacabana Beach on June 14, 2014 in Rio de Janeiro, Brazil. The match was played on the third day of the World Cup tournament. (Photo by Mario Tama/Getty Images)
Actors dressed as native Amazonians take part in an outdoor performance in downtown Manaus on June 13, 2014 in Manaus, Brazil. Group D teams, England and Italy, will play their opening match of the 2014 FIFA World Cup when they meet in Manaus tomorrow. (Photo by Oli Scarff/Getty Images)
A Chile fan shows his tattoos prior to the 2014 FIFA World Cup Brazil Group B match between Chile and Australia at Arena Pantanal on June 13, 2014 in Cuiaba, Brazil. (Photo by Clive Brunskill/Getty Images)
A woman looks at the South Korean flag made with messages supporting South Korea's national football team at the Korea House in Foz do Iguacu, Parana, on June 13, 2014 during the 2014 FIFA World Cup in Brazil. (JUNG YEON-JE/AFP/Getty Images)
A Colombia fan enjoys the atmosphere prior to the 2014 FIFA World Cup Brazil Group C match between Colombia and Greece at Estadio Mineirao on June 14, 2014 in Belo Horizonte, Brazil. (Photo by Ian Walton/Getty Images)
Iran's captain Javad Nekounam attends a training session at the CT Joaquim Grava training ground in Sao Paulo during the 2014 FIFA World Cup football tournament on June 14, 2014. (BEHROUZ MEHRI/AFP/Getty Images)
Daryl Janmaat of the Netherlands lies on the field at the end of the match during the 2014 FIFA World Cup Brazil Group B match between Spain and Netherlands at Arena Fonte Nova on June 13, 2014 in Salvador, Brazil. (Photo by Jeff Gross/Getty Images)
Netherlands fans cheer during the 2014 FIFA World Cup Brazil Group B match between Spain and Netherlands at Arena Fonte Nova on June 13, 2014 in Salvador, Brazil. (Photo by David Ramos/Getty Images)
Jorge Valdivia of Chile shoots and scores his teams second goal against goalkeeper Mathew Ryan of Australia during the 2014 FIFA World Cup Brazil Group B match between Chile and Australia at Arena Pantanal on June 13, 2014 in Cuiaba, Brazil. (Photo by Matthew Lewis/Getty Images)
A protester lies on the ground before a line of riot police during a demonstration against the FIFA World Cup in Belo Horizonte, Brazil on June 12, 2014. (JUAN MABROMATA/AFP/Getty Images)
Anti-World Cup protestors gather while attempting to march to Maracana stadium on June 15, 2014 in Rio de Janeiro, Brazil. The protestors were eventually blocked by police before reaching the stadium. Today is the fourth day of the 2014 FIFA World Cup. (Photo by Mario Tama/Getty Images)
Brazilian supporters hold a picture of France's forward Karim Benzema as they watch France's national football team train at the Santa Cruz Stadium in Ribeirao Preto on June 13, 2014, during the 2014 FIFA World Cup in Brazil. (FRANCK FIFE/AFP/Getty Images)
Chile's goalkeeper Claudio Bravo celebrates after his team scored at the end of a Group B football match between Chile and Australia at the Pantanal Arena in Cuiaba during the 2014 FIFA World Cup on June 13, 2014. (LUIS ACOSTA/AFP/Getty Images)
Masato Morishige (L) and Yuto Nagatomo of Japan challenge Didier Drogba of the Ivory Coast during the 2014 FIFA World Cup Brazil Group C match between the Ivory Coast and Japan at Arena Pernambuco on June 14, 2014 in Recife, Brazil. (Photo by Julian Finney/Getty Images)
A fan of the Ivory Coast cheers in the crowd during the 2014 FIFA World Cup Brazil Group C match between the Ivory Coast and Japan at Arena Pernambuco on June 14, 2014 in Recife, Brazil. (Photo by Jamie Squire/Getty Images)
A man closes a shop selling clothing, including the Brazilian national football team strip, in downtown Manaus on June 13, 2014 in Manaus, Brazil. Group D teams, England and Italy, will play their opening match of the 2014 FIFA World Cup when they meet in Manaus tomorrow. (Photo by Oli Scarff/Getty Images)
People take a photo in front of Military Police blocking a road where anti-World Cup protestors attempted to march near Maracana stadium on June 15, 2014 in Rio de Janeiro, Brazil. Today is the fourth day of the 2014 FIFA World Cup. (Photo by Mario Tama/Getty Images)
Boys play with a football as the Netherlands and Spain play FIFA World Cup 2014 football match, at the Rocinha shantytown in Rio de Janeiro, Brazil, on June 13, 2014. (YASUYOSHI CHIBA/AFP/Getty Images)
A couple embraces with the American flag wrapped around them as they watch the football game featuring Spain vs. Netherland on the giant screen showing the match at the FIFA World Cup Fan Fest on Copacabana beach on June 13, 2014 in Rio de Janeiro, Brazil. The match was played on the second day of the World Cup tournament and Spain lost 5-1. (Photo by Joe Raedle/Getty Images)
A general view of Manaus taken on June 13, 2014, on the eve of the 2014 FIFA World Cup Group D match England vs Italy. (FRANCOIS XAVIER MARIT/AFP/Getty Images)
The Netherlands fans look on wearing feathered headdresses during the 2014 FIFA World Cup Brazil Group B match between Spain and Netherlands at Arena Fonte Nova on June 13, 2014 in Salvador, Brazil. (Photo by David Ramos/Getty Images)
Netherlands' forward Robin van Persie celebrates after scoring during a Group B football match between Spain and the Netherlands at the Fonte Nova Arena in Salvador during the 2014 FIFA World Cup on June 13, 2014. AFP PHOTO / DIMITAR DILKOFF (Photo credit should read DIMITAR DILKOFF/AFP/Getty Images)
RIO DE JANEIRO, BRAZIL - JUNE 13: A Mexican soccer team fan watches his team play against Cameroon on the giant screen showing the match at the FIFA World Cup Fan Fest on Copacabana beach on June 13, 2014 in Rio de Janeiro, Brazil. Mexico won the game 1-0 during the second day of the World Cup tournament. (Photo by Joe Raedle/Getty Images)
A general view shows the pitch at the Amazonia Arena in Manaus on June 13, 2014, on the eve of the 2014 FIFA World Cup football match between England and Italy. AFP PHOTO/ GIUSEPPE CACACE (Photo credit should read GIUSEPPE CACACE/AFP/Getty Images)
A woman crosses a road under street decorations in Manaus, one of the host cities of the 2014 FIFA World Cup, on June 13, 2014, on the eve of a game between England and Italy. AFP PHOTO/BEN STANSALL (Photo credit should read BEN STANSALL/AFP/Getty Images)
Brazil fans cheer their team during the Group A match between Brazil and Croatia on June 12, 2014 in Porto Seguro, Brazil. (Photo by Martin Rose/Getty Images)
Brazilian and Japanese football fans celebrate the victory of Brazilian team against Croatia at the opening game of the 2014 FIFA World Cup at a breakfast meeting after the game at the Brazilian embassy in Tokyo on June 13, 2014. AFP PHOTO / Yoshikazu TSUNO (Photo credit should read YOSHIKAZU TSUNO/AFP/Getty Images)
Fans cheer before the group A World Cup soccer match between Brazil and Croatia, the opening game of the tournament, in the Itaquerao Stadium in Sao Paulo, Brazil, Thursday, June 12, 2014. (AP Photo/Felipe Dana)
Brazilian kids play football on the beach of Cumbuco, Ceara, on June 13, 2014 during the 2014 FIFA World Cup. AFP PHOTO / DANIEL GARCIA (Photo credit should read DANIEL GARCIA/AFP/Getty Images)
SAO PAULO, BRAZIL - JUNE 12: A man runs after exiting the subway to watch the Brazil-Croatia match from a television jerry-rigged on a shopping cart on June 12, 2014 in Sao Paulo, Brazil. This is the first day of the 2014 FIFA World Cup. (Photo by Mario Tama/Getty Images)
A supporter of the Brazilian national football team holds a flag as he celebrates his team's win against Croatia, in Ribeirao Preto on June 12, 2014, after the 2014 FIFA World Cup opening match between Brazil and Croatia which was played at the Corinthians Arena in Sao Paulo. AFP PHOTO / FRANCK FIFE (Photo credit should read FRANCK FIFE/AFP/Getty Images)
Brazilian and Croatian fans watch the Group A opening football match between Brazil and Croatia at Corinthians Arena in Sao Paulo, Brazil during the 2014 FIFA World Cup on June 12, 2014. AFP PHOTO/BEHROUZ EHRI (Photo credit should read BEHROUZ MEHRI/AFP/Getty Images)
Brazil's forward Neymar (C) runs with the ball during a Group A football match between Brazil and Croatia at the Corinthians Arena in Sao Paulo during the 2014 FIFA World Cup on June 12, 2014. AFP PHOTO / ADRIAN DENNIS (Photo credit should read ADRIAN DENNIS/AFP/Getty Images)
Aspiring young Indian soccer players continue with their practice during a dust storm in Jammu, India, Wednesday, June 11, 2014. Soccer fans around the world are gearing up to watch the Soccer World Cup that begins in Brazil Thursday. (AP Photo/Channi Anand)
Japanese fans react after Japan is defeated during the 2014 FIFA World Cup match between Japan and Cote d'Ivoire during the public viewing event at Tokyo Dome on June 15, 2014 in Tokyo, Japan. (Photo by Keith Tsuji/Getty Images)
Brazil and Croatia players stand around the center circle as doves are released before the 2014 FIFA World Cup Brazil Group A match between Brazil and Croatia at Arena de Sao Paulo on June 12, 2014 in Sao Paulo, Brazil. (Photo by Fabrizio Bensch - Pool/Getty Images)
SAO PAULO, BRAZIL - JUNE 12: (Editors Note: Image was created using a fisheye lens) A general view of the arena during the Opening Ceremony of the 2014 FIFA World Cup Brazil prior to the Group A match between Brazil and Croatia at Arena de Sao Paulo on June 12, 2014 in Sao Paulo, Brazil. (Photo by Warren Little/Getty Images)
Brazilian Satere-Mawe indigenous peopel celebrates as they gather to watch the FIFA World Cup inaugural match between Brazil and Croatia, on June 12, 2014 in Manaus, Amazonas state, Brazil. AFP PHOTO / Raphael Alves (Photo credit should read RAPHAEL ALVES/AFP/Getty Images)
A Brazilian Satere-Mawe indigenous main waits to watch the FIFA World Cup inaugural match between Brazil and Croatia, on June 12, 2014 in Manaus, Amazonas state, Brazil. AFP PHOTO / Raphael Alves (Photo credit should read RAPHAEL ALVES/AFP/Getty Images)
Brazil's defender David Luiz celebrates after the Group A football match between Brazil and Croatia at the Corinthians Arena in Sao Paulo during the 2014 FIFA World Cup on June 12, 2014. AFP PHOTO / FABRICE COFFRINI (Photo credit should read FABRICE COFFRINI/AFP/Getty Images)
Riot police arrest a protester in the vicinity of the FIFA Fan Fest in Copacabana Beach in Rio de Janeiro, Brazil on June 12, 2014. Brazil's ambivalence toward the World Cup was on full display as the country geared up for the game, the sea of green and yellow in some areas contrasting with the billowing smoke from burning garbage and clouds of tear gas that filled the air as military police and protesters clashed in the nation's financial hub. AFP PHOTO / YASUYOSHI CHIBA (Photo credit should read YASUYOSHI CHIBA/AFP/Getty Images)
SAO PAULO, BRAZIL - JUNE 12: A CNN journalist is taken from a protest on a stretcher outside Carrao Metro Station on June 12, 2014 in Sao Paulo, Brazil. Military police responded to the protest and there were with reported injuries. This is the first day of the FIFA World Cup. (Photo by Mario Tama/Getty Images)
A protester raises a placard in front of a line of riot police during a demonstration against the 2014 FIFA World Cup in Belo Horizonte, Brazil on June 12, 2014. AFP PHOTO/Eitan ABRAMOVICH (Photo credit should read EITAN ABRAMOVICH/AFP/Getty Images)
Demonstrators gesture at riot police during a protest against the 2014 FIFA World Cup in Belo Horizonte, Brazil on June 12, 2014. AFP PHOTO/Eitan ABRAMOVICH (Photo credit should read EITAN ABRAMOVICH/AFP/Getty Images)
People dressed as flowers take part in the opening ceremony of the 2014 FIFA football World Cup at the Corinthians Arena in Sao Paulo on June 12, 2014. AFP PHOTO / DIMITAR DILKOFF (Photo credit should read DIMITAR DILKOFF/AFP/Getty Images)
A young supporter of the Brazilian national football team waves a flag on June 12, 2014 in Porto Seguro before the opening match of the 2014 FIFA World Cup between Brazil and Croatia being played at the Corinthians Arena in Sao Paulo. AFP PHOTO / ANNE-CHRISTINE POUJOULAT (Photo credit should read ANNE-CHRISTINE POUJOULAT/AFP/Getty Images)
Brazil's goalkeeper Julio Cesar catches a ball during the Group A football match against Croatia at the Corinthians Arena in Sao Paulo during the 2014 FIFA World Cup on June 12, 2014. AFP PHOTO / ODD ANDERSEN (Photo credit should read ODD ANDERSEN/AFP/Getty Images)
Croatia's forward Nikica Jelavic (L) vies for the ball with Brazil's defender David Luiz during their Group A football match at the Corinthians Arena in Sao Paulo during the 2014 FIFA World Cup on June 12, 2014. AFP PHOTO / POOL / FABRIZIO BENSCH (Photo credit should read FABRIZIO BENSCH/AFP/Getty Images)
People watch on a huge screen the Brazil vs Croatia opening match during the FIFA Fan Fest in Copacabana Beach in Rio de Janeiro, Brazil on June 12, 2014. Brazil's ambivalence toward the World Cup was on full display as the country geared up for the game, the sea of green and yellow in some areas contrasting with the billowing smoke from burning garbage and clouds of tear gas that filled the air as military police and protesters clashed in the nation's financial hub. AFP PHOTO / YASUYOSHI CHIBA (Photo credit should read YASUYOSHI CHIBA/AFP/Getty Images)
Croatian football fans react as they watch the opening match of the 2014 FIFA World Cup, a group A football match between Croatia and Brazil, on June 12, 2014, in the Croation capital Zagreb's main square. Several thousands of people gathered at Zagreb's main square to watch the match between Croatia and Brazil on a giant screen. AFP PHOTO / STRINGER (Photo credit should read STR/AFP/Getty Images)
People take part in the opening ceremony of the 2014 FIFA football World Cup at the Corinthians Arena in Sao Paulo on June 12, 2014. AFP PHOTO / DIMITAR DILKOFF (Photo credit should read DIMITAR DILKOFF/AFP/Getty Images)
Costa Ricans celebrate while watching their victory over Uruguay at the FIFA Fan Fest on Copacabana Beach on June 14, 2014 in Rio de Janeiro, Brazil. The match was played on the third day of the World Cup tournament. (Photo by Mario Tama/Getty Images)
Mexican soccer team fans react to their team winning the match against Cameroon as they watch it on the giant screen showing the match at the FIFA World Cup Fan Fest on Copacabana beach on June 13, 2014 in Rio de Janeiro, Brazil. Mexico won the game 1-0 during the second day of the World Cup tournament. (Photo by Joe Raedle/Getty Images)
Fans od Colombia's soccer team celebrate at the end of a 2014 World Cup qualifying soccer match against Chile in Barranquilla, Colombia, Friday, Oct. 11, 2013. Colombia tied 3-3 and booked its ticket for the 2014 finals in Brazil.(AP Photo/Fernando Vergara)
Aerial view of the Maracana stadium during sunset in Rio de Janeiro, Brazil, Sunday, June 8, 2014. The Word Cup soccer tournament is set to begin in just a few days, with the opening match on June 12 and Maracana stadium will host the World Cup Final match on July 13. (AP Photo/Felipe Dana)
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MIAMI BEACH, FL - DECEMBER 04: Kanye West (L) and Kim Kardashian attend DuJour Magazine's event to honor artist Marc Quinn at Delano South Beach Club on December 4, 2013 in Miami Beach, Florida. (Photo by Eugene Gologursky/Getty Images for DuJour Magazine)
LAS VEGAS, NV - OCTOBER 26: Rapper Kanye West (L) and television personality Kim Kardashian arrive at the Tao Nightclub at The Venetian Las Vegas to celebrate Kardashian's 33rd birthday on October 26, 2013 in Las Vegas, Nevada. (Photo by Ethan Miller/Getty Images,)
Kanye West, left, and Kim Kardashian arrive to attend Givenchy's ready-to-wear Spring/Summer 2014 fashion collection, presented Sunday, Sept. 29, 2013 in Paris. (AP Photo/Zacharie Scheurer)
US musician Kanye West and partner Kim Kardashian pose prior to Givenchy 2014 Spring/Summer ready-to-wear collection fashion show, on September 29, 2013 in Paris. AFP PHOTO / PIERRE ANDRIEU (Photo credit should read PIERRE ANDRIEU/AFP/Getty Images)
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US actress Blake Lively poses as she arrives for the screening of the film 'Mr. Turner' at the 67th edition of the Cannes Film Festival in Cannes, southern France, on May 15, 2014.
Blake Lively arriving at the Mr Turner Premiere, part of the 67th Festival de Cannes, Palais du Festival, Cannes.
Canadian actor Ryan Reynolds and his wife US actress Blake Lively pose as they arrive for the screening of the film 'Captives' at the 67th edition of the Cannes Film Festival in Cannes, southern France, on May 16, 2014. AFP PHOTO / LOIC VENANCE (Photo credit should read LOIC VENANCE/AFP/Getty Images)
CANNES, FRANCE - MAY 14: Actress Zoe Saldana attends the Opening ceremony and the 'Grace of Monaco' Premiere during the 67th Annual Cannes Film Festival on May 14, 2014 in Cannes, France.
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× CORONAVIRUS: The latest coverage and local resources regarding COVID-19 from the Arizona Public Media newsroom.
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Noise pollution in Arizona
March 20, 2020 / Modified mar 20, 2020 10:40 a.m.
From the skies and on the ground, constant noise can come with serious health risks.
by Ariana Brocious TWEET SHARE
An A-10 Thunderbolt II flying for a mission in support of Operation Inherent Resolve, May 2017.
Michael Battles, U.S. Department of Defense
Tucsonans can reliably count on a few things: vivid sunsets, superior Mexican food and the sound of aircraft flying overhead. Most residents of central Tucson are familiar with the sound of the A-10 attack plane from nearby Davis-Monthan Air Force Base.
Gary Hunter has lived near Glenn Street and Elm Street for two decades.
“Fifteen years ago, they [A-10s] were fairly loud and bothersome, but since then the Air Force has raised the altitudes that they fly over through the midtown neighborhoods, so they’re not too bad,” Hunter told The Buzz. “But we also have F-16s going over. Those are twice as bad as the A-10s and they are bothersome.”
He said he is worried about the possible introduction of F-35s to the base, which are louder than both the A-10s and the F-16s. Davis-Monthan is one of four bases currently in the running to get an F-35 squadron.
“They’re going to be absolutely intolerable,” he said.
At a recent public hearing, the Air Force met to explain the environmental impacts of basing the F-35s at Davis-Monthan.
Hamid Kamalpour is a civil engineer with the Air Force and is the program manager for the F-35’s environmental impact statement.
“If this was not a significant impact, we would have just done environmental assessment and we would have concluded with finding of no significant impact, but in this case, we have significant impact with the noise,” Kamalpour said.
At the public meeting, several people expressed that they thought the planes were too loud. Longtime central Tucson resident Manon Getsi said that when F-35s fly overhead, her home shakes. Public comments on the Environmental Impact Statement can be submitted until March 31.
Noise pollution concerns in Arizona aren't limited to the skies overhead. Karthic Thallikar has been in a years-long battle to get relief from the sound of from the CyrusOne Data Center located a half-mile from his home in Chandler.
After many complaints to city officials, police and the company itself, he did manage to spur some changes to deal with the noise, which comes from chillers used to keep the server farm at the right temperature. Before that, Thallikar said the noise was ever-present.
"The noise from the CyrusOne Data Center was a very annoying, disturbing noise,” Thallikar told The Buzz. “It was constant, 24/7, 365 days a year. It was a very high-pitched ‘eeeee’ noise, constantly.” Thallikar said that the noise increased feelings of anxiety and helplessness, which lead to other effects on his health, like trouble sleeping and increased blood pressure.
After months of noise, a group of Chandler residents attempted to work with CyrusOne, but these attempts were brushed aside, according to Thallikar. They were finally able to work with the city and get through to the data company. The company has since installed material around the chillers, which has helped reduce the noise.
“On many days we don’t hear the noise, but when we hear the noise, we hear it really badly,” Thallikar said. “So, I would say it has worked about 60% of the time, but the other 40% it does not.”
Noise pollution expert Richard Neitzel is a public health scientist at the University of Michigan. Neitzel said at its simplest, noise pollution is unwanted or harmful sound in the environment around us. It doesn't have to be loud or even especially bothersome to be harmful.
"Low-level sound that's well within our tolerance or ability to cope with can still be causing harm to our cardiovascular system even if it's not hurting our ears,” Neitzel told The Buzz.
According to Neitzel, chronic noise pollution has been linked to hearing loss, high blood pressure, heart attacks and strokes. It can also have a negative impact on people’s mental health and cognition.
“Each year we advance, we are learning more about new emerging health impacts in addition to those,” he said.
Even sources of noise that may not be loud enough to cause hearing loss, like highways and airports, can lead to negative cardiovascular effects. The jury is still out on whether or not most these effects can be reversed, Neitzel said.
The Buzz airs Fridays at 8:30 a.m. and 6 p.m. and Saturdays at 3:30 p.m. on NPR 89.1. You can subscribe to our podcast on iTunes and NPR One. See more from The Buzz.
MORE: Davis-Monthan Air Force Base, Health & Medicine, Military, News, The Buzz
Air Force seeking public comment on basing F-35 jets in Tucson Pima County expands COVID-19 vaccine rollout UA to start vaccinations Jan. 22
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Vermaat to supply catering services for KLM’s Schiphol Lounges
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persberichten,
Catering company Vermaat is to supply the catering concept for the Non-Schengen Crown Lounge (52) and the Schengen Crown Lounge (25) at Schiphol. KLM Royal Dutch Airlines and Vermaat signed a partnership agreement at the KLM Dutch Open golf tournament.
This new deal aims to provide the ultimate customer experience. Excellent service combined with new food-and-beverages concepts are being developed for both KLM lounges and will include stylish, high-quality, pure products and live cooking.
Vermaat has developed as a leading company in catering and retail concepts and already has many years’ experience at Schiphol. Vermaat's culinary expertise will raise the standard of KLM’s lounge products for all its lounge visitors. In future, it will also be possible to order and pay for additional premium products in advance. KLM and Vermaat will be developing the details of the agreement in the months ahead.
Non Schengen KLM Crown Lounge (52)
The Non Schengen KLM Crown Lounge is currently undergoing major reconstruction work. In addition to the new catering concept, it will also be fitted with an extra level, an outside terrace, and a new interior offering the most up-to-date technologies, design and experience. Once the renovation has been completed, the lounge will hold around 1450 seats and measure 6300 m2, compared to its current 680 seats and 2500 m2. The building work is being carried out in phases, with the first phase due to be completed in the summer of 2018. The lounge will finally be completed in the spring of 2019. The lounge remains partially open throughout this time.
Photo: Vermaat General Director & CEO, Rick Zeelen, and KLM President & CEO, Pieter Elbers, sign the partnership agreement at the KLM Open.
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HomeCelebrity NewsI am not a rapist- Peruzzi cries out.
I am not a rapist- Peruzzi cries out.
Nigerian singer and songwriter, Peruzzi, whose real name is Tobechukwu Victor Okoh, is surely fighting the battle of his life to save his career, after a Twitter user accused him of raping her in his apartment eight years ago. The Twitter user who goes by the username, @Jayamah22, recalls how she was raped by the DMW record label signee, when she accompanied her girlfriend to the musician’s place at Victoria Island, Lagos. According to her, her girlfriend was dating Peruzzi at the time and went to spend the night with her man. At night according to Jayamah, Peruzzi came to meet her where she was sleeping and forcefully had his way with her, despite her pleas. She claimed she could not come out to talk at that time, because she was naïve and her parents, who thought she was in school, didn’t know she was in Lagos then. Peruzzi, who is not new to being accused of rape, as he was accused earlier this year of rape by a UK based singer, Daffy Blanco, has not really responded to this allegation, but on Wednesday, he went on Twitter and tweeted “My name is Okoh Tobechukwu, I have never and will never be a rapist.” Will this be enough to clear him of all these rape allegations or would there be more twists to these allegations? Only time can tell.
davido sustains leg injury, confined to crutches.
Premier League releases revised 2019/20 fixtures
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Home » About Us » Lottery News
Governor Sununu Signs Sports Betting Bill into Law as NH Lottery Breaks All-time Sales and Revenue Records
CONCORD, N.H. – On the heels of the New Hampshire Lottery announcing all-time sales and revenue records, Governor Chris Sununu signed House Bill 480 today, authorizing the New Hampshire Lottery to conduct sports betting. Governor Sununu was joined today at the New Hampshire Lottery by Charlie McIntyre, executive director of the New Hampshire Lottery, Debra Douglas, chairman of the New Hampshire Lottery Commission, and House Bill 480 sponsors to celebrate passage of the sports betting legislation.
To kick off the bill signing ceremony, the New Hampshire Lottery announced it has shattered its all-time sales record during Fiscal Year 2019, generating more than $384.2 million in total sales and returning more than $100.7 million to New Hampshire for state education. This marks a 15.4-percent or $13.5 million year-over-year increase in education aid and a 15.5-percent or $51.4 million year-over-year increase in total sales, according to unaudited figures.
“Sports betting is the right bet for New Hampshire,” said Governor Chris Sununu. “With the exciting new addition of sports betting, the New Hampshire Lottery will continue to drive critical revenue, putting even more money into our educational system. Today’s action will provide financial support and important resources to help our public education system, which will benefit every child in every school across the state — a win for New Hampshire.”
The sports betting legislation, which creates a Division of Sports Wagering within the New Hampshire Lottery to oversee sports betting, allows for mobile wagering and prohibits any wagering on New Hampshire college teams or any college games taking place in the Granite State. Players must be 18 or older to make wagers.
“I am pleased with our record-breaking sales success and especially that the New Hampshire Lottery has sustained its core mission in remaining an important force in raising education revenue for the state,” said Charlie McIntyre, executive director of the New Hampshire Lottery. “Sports betting represents an exciting new chapter for the New Hampshire Lottery and our loyal players. The New Hampshire Lottery is well-positioned to strategically administer sports betting to maximize revenue and to protect our consumers.”
A number of factors have contributed to the New Hampshire Lottery’s success over the past year. Highlighted by a $1.6 billion jackpot in October 2018, Mega Millions sales jumped by 85-percent, from about $17 million in Fiscal Year 2018 to nearly $31.5 million in Fiscal Year 2019. Scratch tickets continued to play an important role in driving sales, generating $249.9 million in sales, an $11.6 million increase from last year. In addition, KENO 603 sales increased by nearly 224-percent, from $8.3 million to $26.8 million this past fiscal year.
“This is an ongoing team effort and we are fortunate to have a strong group of creative, thoughtful, and dedicated staff, who have worked tirelessly to help meet this important milestone of raising more than $100 million for New Hampshire education for the first time in our history,” McIntyre continued. “We are also proud of our retail network, which is comprised of many small businesses, as this will be a record year of revenues earned by them.”
A natural next step in the New Hampshire Lottery’s evolution, iLottery has played an important role in driving sales, with the new online platform generating more than $6.4 million in sales since its launch in September 2018. Currently, more than 47,000 players have signed up for iLottery, which offers players the opportunity to play Powerball, Mega Millions and twenty e-Instant games.
The New Hampshire Lottery is not only the fastest growing lottery in New England, it is one of the fastest growing lotteries in the United States. In the past five years, New Hampshire Lottery sales have increased by 39-percent, an increase of $107.4 million over that time period. Since its inception in 1964, the New Hampshire Lottery has contributed more than $2 billion to education.
Photos and Captions
Caption: Governor Chris Sununu signed House Bill 480 today, authorizing the New Hampshire Lottery to conduct sports betting. Pictured here, Governor Sununu poses with bill sponsors and New Hampshire Lottery leadership prior to signing the bill. With Governor Sununu seated at the table, pictured, from left to right, Rep. Fred Doucette, Rep. J.P. Marzullo, New Hampshire Lottery Executive Director Charlie McIntyre, Rep. John Potucek, Rep. Brian Chirichiello, Rep. Howard Pearl, Rep. Timothy Lang, New Hampshire Lottery Commission Chairman Debra Douglas and New Hampshire Chief Compliance Officer John Conforti.
Caption: Governor Chris Sununu signed House Bill 480 today, authorizing the New Hampshire Lottery to conduct sports betting. Pictured here, Governor Sununu poses with bill sponsors and New Hampshire Lottery leadership after formally signing the bill. With Governor Sununu seated at the table, pictured, from left to right, Rep. Fred Doucette, Rep. J.P. Marzullo, New Hampshire Lottery Executive Director Charlie McIntyre, Rep. John Potucek, Rep. Brian Chirichiello, Rep. Howard Pearl, Rep. Timothy Lang, New Hampshire Lottery Commission Chairman Debra Douglas and New Hampshire Chief Compliance Officer John Conforti.
Caption: In addition to signing House Bill 480 into law today at the New Hampshire Lottery, Governor Chris Sununu joined with New Hampshire Lottery officials to celebrate that the New Hampshire Lottery broke its all-time sales record during Fiscal Year 2019, generating more than $384.2 million in total sales and returning more than $100.7 million to New Hampshire for state education. Pictured here, Governor Sununu addresses the crowd, while New Hampshire Lottery Executive Director Charlie McIntyre and New Hampshire Lottery Commission Chairman Debra Douglas look on.
Caption: The New Hampshire Lottery announced today it has shattered its all-time sales record during Fiscal Year 2019, generating more than $384.2 million in total sales and returning more than $100.7 million to New Hampshire for state education. This marks a 15.4-percent or $13.5 million year-over-year increase in education aid and a 15.5-percent or $51.4 million year-over-year increase in total sales, according to unaudited figures. Pictured here, New Hampshire Lottery Executive Director Charlie McIntyre addresses the crowd, while New Hampshire Lottery Commission Chairman Debra Douglas looks on.
About New Hampshire Lottery
Since 1964, the New Hampshire Lottery has had a significant financial impact on the state. For the past 55 years, the New Hampshire Lottery has recorded more than $6.7 billion in lottery sales and other earnings, with over $4.5 billion paid in prizes and other cost of sales. Net proceeds to education total over $2 billion to date.
The New Hampshire Lottery Commission, located at 14 Integra Drive in Concord, currently manages all lottery operations in the state, including instant games, New Hampshire Powerball®, New Hampshire Mega Millions®, Tri-State Megabucks℠, Tri-State Pick3®/Pick4® Daily Numbers games, Gimme 5, Fast Play games, Lucky For Life®, KENO 603℠ and iLottery.
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NoDeposit.io
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e- by us if required as part of a bona fide sale of our business (assets or shares, whether in whole or in part) to a third party, provided that we enter into a confidentiality agreement with the third party on terms no less restrictive than this clause VIII.
IX- Warranties
Each party warrants that it has full power and authority to enter into, and perform its obligations under, these Terms.
To the maximum extent permitted by law:
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b- we make no representation concerning the quality of the Service and do not promise that the Service will:
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ii- be secure, free of viruses or other harmful code, uninterrupted or error-free.
You agree and represent that you are acquiring the Service, and accepting these Terms, for the purpose of trade. The parties agree that:
a- to the maximum extent permissible by law and any other applicable consumer protection legislation does not apply to the supply of the Service or these Terms; and
b- it is fair and reasonable that the parties are bound by this clause IX.3.
Where legislation or rule of law implies into these Terms a condition or warranty that cannot be excluded or modified by contract, the condition or warranty is deemed to be included in these Terms. However, our liability for any breach of that condition or warranty is limited, at our option, to:
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X- Liability:
Our maximum aggregate liability under or in connection with these Terms or relating to the Service, whether in contract, tort (including negligence), breach of statutory duty or otherwise, must not in any Year exceed an amount equal to the Fees paid by you relating to the Service in the previous Year (which in the First Year is deemed to be the total Fees paid by you from the Start Date to the date of the first event giving rise to liability). The cap in this clause X.1 includes the cap set out in clause IX.2a.
Neither party is liable to the other under or in connection with these Terms or the Service for any:
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Clauses X.1 and X.2 do not apply to limit our liability under or in connection with these Terms for:
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Unless terminated under this clause XI, these Terms and your right to access and use the Service:
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i- remedied within 10 days of the receipt of a notice from the first party requiring it to remedy the breach; or
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b- becomes insolvent, liquidated or bankrupt, has an administrator, receiver, liquidator, statutory manager, mortgagee’s or chargee’s agent appointed, becomes subject to any form of insolvency action or external administration, or ceases to continue business for any reason.
You may terminate these Terms and your right to access and use the Service in accordance with clause VI.6.
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At any time prior to one month after the date of termination, you may request:
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b- deletion of the Data stored using the Service, in which case we must use reasonable efforts to promptly delete that Data.
To avoid doubt, we are not required to comply with clause XI.9a to the extent that you have previously requested the deletion of the Data.
Without limiting any other right or remedy available to us, we may restrict or suspend your access to and use of the Service and/or delete, edit or remove the relevant Data if we consider that you or any of your personnel have:
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c- transmitted, inputted or stored any Data that breaches or may breach these Terms or any third party right (including Intellectual Property Rights and privacy rights), or that is or may be Objectionable, incorrect or misleading; or
d- otherwise materially breached these Terms.
XII- General:
These terms are to be understood and interpreted in the context of our Privacy and Terms accessible with this link.
Subject to clause V.4, we are your independent contractor, and no other relationship (e.g. joint venture, agency, trust or partnership) exists under these Terms.
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You may give notice to us under or in connection with these Terms by emailing legal@nodeposit.io.
These Terms, and any dispute relating to these Terms or the Website, are governed by and must be interpreted in accordance with the laws of Singapore. Each party submits to the non-exclusive jurisdiction of the Courts of Singapore in relation to any dispute connected with these Terms or the Website.
Clauses which, by their nature, are intended to survive termination of these Terms, including clauses V.7, VII, IX, X, XI.5 to XI.9 and XII.5, continue in force.
If any part or provision of these Terms is or becomes illegal, unenforceable, or invalid, that part or provision is deemed to be modified to the extent required to remedy the illegality, unenforceability or invalidity. If modification is not possible, the part or provision must be treated for all purposes as severed from these Terms. The remainder of these Terms will be binding on you.
Any variation to these Terms must be in writing.
These Terms set out everything agreed by the parties relating to the Service, and supersede and cancel anything discussed, exchanged or agreed prior to the Start Date. The parties have not relied on any representation, warranty or agreement relating to the Service that is not expressly set out in these Terms, and no such representation, warranty or agreement has any effect from the Start Date. Without limiting the previous sentence, the parties agree that it is fair and reasonable that the parties are bound by this clause XII.9.
You may not assign, novate, subcontract or transfer any right or obligation under these Terms without our prior written consent, that consent not to be unreasonably withheld. You remain liable for your obligations under these Terms despite any approved assignment, subcontracting or transfer.
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Hinckley boss Belford steps down
Dec 28, 2017 | Top Stories
Hinckley AFC manager Dale Belford has stepped down from his role with the club. The club’s announcement cited personal reasons behind Belford’s decision and he leaves the Midland League First Division side after enjoying an impressive eight wins from 12...
Billericay u-turn for Pennant
Jermaine Pennant looked to be leaving Billericay Town after just four months at the club, but after a u-turn, it is announced he will be staying put.. Pennant joined the Isthmian Premier League club in August and manager Glenn Tamplin had said to the Basildon Standard...
Harris takes Redditch United job
Redditch United have announced the appointment of Tim Harris as its new first-team manager. The 58-year-old replaces Darren Byfield and arrives at The TRICO Stadium with a wealth of experience, having enjoyed managerial spells with Cinderford Town, Newport County,...
Gosport Borough taken over by ex-Pompey chairman
Evo-Stik League South Premier strugglers Gosport Borough have released an official statement regarding the takeover of the club. The statement reads as follows: Gosport Borough Football Club are delighted to confirm that it has successfully negotiated a takeover deal...
Byfield leaves Redditch United post
Darren Byfield has left his post as Redditch United manager. Byfield’s former Aston Villa and Gillingham teammate Danny Jackman has taken caretaker charge of the Evo-Stik League South Premier side. The Worcestershire club released the following statement after...
Eastleigh appoint Hessenthaler as Hill takes new role
Vanarama National League strugglers Eastleigh have appointed ex-Gillingham boss Andy Hessenthaler as their new manager. Following recent ongoing discussions, it has been agreed that previous boss Richard Hill will move into a full-time role as director of football....
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Olympic Alpine skiing schedule
By OlympicTalkFeb 2, 2018, 9:00 AM EST
NBCOlympics.com will live stream every event of the PyeongChang Winter Games.
The Alpine skiing streaming schedule is here.
The sport’s full, event-by-event schedule is here:
Men’s Downhill
Feb. 10 9-11:05 p.m. ET
Women’s Giant Slalom
Feb. 11 8:15-9:55 p.m. ET (Run 1)
11:45 p.m.-1:35 a.m. ET (Run 2)
Men’s Combined
Feb. 12 9:30-11:10 p.m. ET (Run 1)
1-2:25 a.m. ET (Run 2)
Women’s Slalom
Men’s Super-G
Women’s Super-G
Men’s Giant Slalom
Women’s Downhill
Men’s Slalom
Women’s Combined
Feb. 22 9-10:25 p.m. ET (Run 1)
12:30-1:45 a.m. ET (Run 2)
Olympic Schedules: Alpine Skiing | Biathlon | Bobsled | Cross-Country Skiing | Curling | Figure Skating | Freestyle Skiing | Hockey | Luge | Nordic Combined | Short Track Speed Skating | Skeleton | Ski Jumping | Snowboarding | Speed Skating
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Reports Tabled in Parliament (1)
Parole Board of Canada (1)
Access to information and Privacy (1)
PBC (1)
Privacy Act (1)
Economics and Industry (1)
Persons (1)
Not Planned (1)
Statistics Canada Parole Board of Canada Fisheries and Oceans Canada Open Information Accès à l’information et de la protection des renseignements personnels Cours Orientation sexuelle Contrevenants olympique Directive Accidents cérébrovasculaires Produits analytiques Mollusque HTML Government and Politics
Parole Board of Canada Annual Report to Parliament on the Privacy Act
The Privacy Act provides members of the public with the legislated right to access and request the correction of their personal information under the control of federal government institutions. The Act also imposes strict obligations related to the collection, accuracy, use, disclosure, retention...
Parole Board of Canada
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10 Essential Facts on Measure 97 tax
Thursday August 18, 2016
By Taxpayer Association of Oregon
1. It is a hidden sales tax
Measure 97 is a gross receipts tax. It increases the business minimum tax to $30,000 plus 2.5% of gross sales on larger businesses where sales (not profits) exceed $25 million. Unlike a retail sales tax that consumers see when they make a purchase, Measure 97 would be like a hidden sales tax. A former state economist said it is like “a sales tax on steroids”
2. Oregon consumers bear the burden for Measure 97
Oregon estimates that more than two-thirds of the tax would be passed on to Oregon consumers in higher prices for everyday essentials like utilities, groceries, prescriptions, phones, insurance and medical care.
3. Oregon’s largest tax increase
Measure 97 is expected to bring in $3 billion in new taxes every year ($6 billion per 2-year budget cycle). This makes it the largest tax increase in Oregon history.
4. A billion in 2009, now $3 billion?
In 2009, Oregon lawmakers raised a billion dollars in new taxes on income, business, gas and hospitals. Despite billions in new permanent revenue they’re back with M97 which is three times the size.
5. It’ll cost you $613 in higher costs
Measure 97 will escalate the cost of consumer goods. It would cost Oregon households between $372 and $1,282 dollars per year ($613 average) as a result of higher prices and other impacts from this tax on sales.
6. Hurts the poor the most
This tax hurts lower income and fixed income families more because they spend a greater share of their income on groceries, clothing & utilities which would increase under Measure 97.
7. We would lose 38,200 jobs, yet it adds 17,000 government jobs
Oregon would lose 38,200 private sector jobs because the $3 billion tax will depress wage growth, increase layoffs and result in fewer jobs created. One study estimates that Measure 97 will help fund 30,000 new government jobs over the next 10 years. State jobs are almost twice the cost of private sector jobs which create a large lifelong bill for Oregonians to pay.
8. Food & clothing tax jump from $70 million to $600 million
Retailers (grocery, medicine, clothing) as a whole would see their total taxes jump from $70 million to $600 million.
9. Utility bills up 5%
Utility companies across Oregon estimate increases between 3 and 5%, burdening low income families the most, and increasing operating costs to small business.
10. It’s a tax on sales – not profits
Companies with small profit, large profit or no profit at all would be forced to pay this huge new tax.
More details on hidden taxes…
Hidden taxes are secret key to unlimited taxation
Europe introduced their first hidden sales tax in 1973 at a rate of 10%. Today, the tax is a staggering 21% on average! By removing the sales tax from public view (no longer on store receipts) it allowed politicians to double the people’s taxes over time without the public ever seeing it. As grocery prices soared people blamed local businesses when it was in fact the hidden tax.
Tax on a tax on tax
M97 is a “tax on a tax” compounded at each step in the supply chain. It’s possible for an item at retail to have been taxed at 5%, 7.5% or even 10%. Below is an example on how this type of tax works elsewhere.
Read more about Measure 97 at Defeat97.com
Cascade Policy Institute Opposes Measure 97, the “Sales Tax on Steroids”
10 Essential Cuban Facts from an Oregon visit
Bud Pierce reacts to Kate Brown’s support of IP-28/Measure 97
Executive Club – IP28 Tax on Sales Measure
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Contact Streetsblog NYC
Streetsblog NYC Logo
S-Cop-Laws
One Month After Fatal Bike Crash, NYPD Hasn’t Answered Key Questions
By Ben Fried
NYPD’s F.O.I.L. Unit denied a request for information about the crash that killed cyclist Solange Raulston in December, citing an ongoing investigation after published reports indicated that the driver had already been cleared.
On December 13, Solange Raulston was struck and killed by a truck driver as she was biking on Nassau Avenue in Greenpoint. One month later, scarcely any details about the collision are available. The NYPD has shielded records of the investigation from public scrutiny, and attempts to learn precisely how this deadly crash happened, determine culpability, and glean lessons to prevent future deaths have so far been thwarted.
Solange Raulston
Here’s what we know: Raulston and the truck driver were both heading west on Nassau near the intersection of McGuinness Boulevard when she was struck. The police department says she was sideswiped by the truck driver, who was not drunk, stayed at the scene, and faces no criminal charges or summonses.
Here’s a partial list of what we don’t know. 1) The precise location of the crash — in a phone call this morning, NYPD’s public information office could not even say on which side of McGuinness the collision occurred. 2) Are there eyewitness accounts that might shed light on the speed of the vehicle and other circumstances of the crash? According to the Daily News, several onlookers were present at the crash scene, but NYPD could not tell Streetsblog whether any witness accounts are on file. 3) Whether the driver was legally permitted to use Nassau Avenue, which is not a designated truck route.
One month after the crash, these basic facts remain out of public view.
There are ways to extract information about crash investigations out of NYPD. Using New York’s Freedom of Information Law, Charles Komanoff and the advocacy group Right Of Way were able to piece together details on dozens of cyclist fatalities in New York City from 1995 to 1998 for their report, "The Only Good Cyclist" [PDF], which concluded that drivers were highly or partly culpable in 41 out of 53 cases.
In the Raulston case, however, NYPD has refused to make records of the crash available after receiving a FOIL request for their release. Streetsblog reader BicyclesOnly submitted a request on December 14 for documents related to the crash investigation. Press accounts had already been published stating that the truck driver would face no charges. Nevertheless, NYPD responded a week later, denying access to the records on the grounds that release "would interfere with law enforcement investigations and/or judicial proceedings." The denial was appealed on January 8, and NYPD has yet to respond to the appeal.
If you want to understand why traffic deaths happen, says Transportation Alternatives senior policy advisor Noah Budnick, there are two challenges: getting NYPD to
release the information, and how the police collect information in the first place. "We’ve
found that the amount of data that’s collected at the scene, especially
when it comes to bikers and walkers, is insufficient," he said. "They
don’t include a box to note the travel speeds of vehicles before the
crash. There’s nothing to record if the driver had a suspended or
revoked license. There’s no specific space to record roadway
characteristics or street design. There’s nothing that prompts them to
automatically look for a truck route sign, bike lane, or other feature."
Roadway characteristics are highly relevant to the Raulston case. Images of the area near the crash scene on Google Street View clearly depict signs stating that Nassau Avenue is not a truck route.
Streetsblog asked NYPD this morning if the investigation was still open, and received a prompt reply via email from a Detective Crispin: "There was no criminality suspected in this accident." So, the police suspect no criminality. That’s still about the only thing we can say for sure.
Filed Under: NYPD, Street Safety, Traffic Justice
OPINION: A Livable Streets Agenda for the 2021 Mayor’s Race … And Beyond
Thursday’s Headlines: So, Did Anything Important Happen Yesterday Edition
Memo to Buttigieg: US DOT Needs an Active Transportation Administration
Comptroller Stringer’s Chauffeur Racked Up Eight School Zone Speeding Tickets In 2020
Staten Island Pedestrian Run Down and Killed — Driver Gets Summons
Over Three Months Later, NYPD Still Withholding Raulston Crash Info
By Brad Aaron | Apr 15, 2010
With at least six crashes leaving three injured and two pedestrians and a cyclist dead, it has been a particularly hellish week to walk and bike the streets of New York. And while information about such incidents is vital to making conditions safer and preventing future fatalities, NYPD continues to withhold crash reports from the […]
Greenpoint Hit-and-Run Victim Dies. McGuinness Blvd Must Be Tamed.
By Noah Kazis | Apr 20, 2010
Calyer Street and McGuinness Boulevard, where a driver killed Neil Chamberlain and fled the scene. Image: Google Maps. Gothamist reports that Neil Chamberlain, a 28-year-old Williamsburg resident, was taken off life support today after a driver struck him and fled the scene in Greenpoint early Sunday morning. The still-unidentified driver was traveling east on Calyer […]
Speed Survey Confirms Deadly McGuinness Boulevard Is Out of Control
By Brad Aaron | Mar 27, 2012
A study released today finds that two out of three motorists speed on Brooklyn’s McGuinness Boulevard [PDF], a notorious Greenpoint thoroughfare where locals have for years called on the city to take action to prevent pedestrian and cyclist injuries and deaths. The McGuinness Boulevard Working Group — comprised of Transportation Alternatives, Neighbors Allied for Good […]
Levin to DOT: Deadly McGuinness Blvd Needs Traffic Calming, Speed Cams
By Stephen Miller | Jan 7, 2014
A week after Nicole Detweiler was killed while walking on McGuinness Boulevard — at least the third person to be struck and killed on the street in the last five years — Council Member Steve Levin sent a letter to incoming Transportation Commissioner Polly Trottenberg asking her to prioritize traffic calming and and speed cameras […]
Months After Traffic Deaths, NYPD Denies Access to Crash Information
At the beginning of the year, Streetsblog embarked on a project we hope will shed light on city pedestrian and cyclist fatalities that appear to have been written off as blameless "accidents." To date, we have filed freedom of information requests with NYPD pertaining to 10 pedestrian deaths, and will be reporting on the progress […]
The Weekly Carnage
By Brad Aaron | Dec 18, 2009
The Weekly Carnage is a Friday round-up of motor vehicle mayhem across the metro region. For more on the origins and purpose of this column, please read About the Weekly Carnage. Cyclist Solange Raulston, 33, was killed on December 13 when she was hit by the driver of a flatbed truck at a Greenpoint intersection […]
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You searched for subject:(Metal homeostasis). Showing records 1 – 30 of 32 total matches.
1. Patel, Sarju. Functional Diversity of Homologous P1B-ATPases in Metal Homeostasis and Host-Microbe Interaction.
Degree: PhD, 2016, Worcester Polytechnic Institute
URL: etd-040416-140014 ; https://digitalcommons.wpi.edu/etd-dissertations/473
► Copper and iron are trace elements that form an indispensable part of many proteins and are crucial for the well-being of all cells. At… (more)
▼ Copper and iron are trace elements that form an indispensable part of many proteins and are crucial for the well-being of all cells. At the same time, the intracellular levels of these metals require careful regulation, as excess or deficiency may be lethal. P1B-ATPases are key players in metal homeostasis. They belong to the superfamily of P-type ATPases, transmembrane proteins present in virtually all life forms, are responsible for solute translocation across biological membranes. The goal of this thesis is to improve our understanding of the structural and functional roles of P1B-ATPases in metal homeostasis by focusing on the host-microbe interaction. The thesis first describes the importance of Cu+ distribution in the outcome of host-microbe interaction. Copper is an important element in host-microbe interactions, acting both as a catalyst in enzymes and as a potential toxin. Cu+-ATPases drive cytoplasmic Cu+ efflux and protect bacteria against metal overload. Many pathogenic and symbiotic bacteria contain multiple Cu+-ATPase genes within particular genetic environments, suggesting alternative roles for each resulting protein. This hypothesis was tested by characterizing five homologous Cu+-ATPases present in the symbiotic organism <I>Sinorhizobium meliloti</I>. Mutation of each gene led to different phenotypes and abnormal nodule development in the alfalfa host. Distinct responses were detected in free-living <I>S. meliloti</I> mutant strains exposed to metal and redox stresses. Differential gene expression was detected under Cu+, oxygen or nitrosative stress. These observations suggest that CopA1a maintains the cytoplasmic Cu+ quota and its expression is controlled by Cu+ levels. CopA1b is also regulated by Cu+ concentrations and is required during symbiosis for bacteroid maturation. CopA2-like proteins, FixI1 and FixI2, are necessary for the assembly of two different cytochrome <I>c</I> oxidases at different stages of bacterial life. CopA3 is a phylogenetically distinct Cu+-ATPase that does not contribute to Cu+ tolerance. It is regulated by redox stress and required during symbiosis. We postulated a model where non-redundant homologous Cu+-ATPases, operating under distinct regulation, transport Cu+ to different target proteins. In its second part, the thesis describes the novel Fe2+-ATPases and their influence in the host-microbe interaction. Little is known about iron efflux transporters in bacterial systems. Recently, the participation of <I>Bacillus subtilis</I> PfeT, a P1B4-ATPase, in cytoplasmic Fe2+ efflux has been proposed. We report here the distinct roles of mycobacterial P1B4-ATPases in the homeostasis of Co2+ and Fe2+. Mutation of <I>Mycobacterium smegmatis ctpJ</I> affects the homeostasis of both ions. Alternatively, a <I>M. tuberculosis ctpJ</I>… Advisors/Committee Members: Arne Gericke, Committee Member, José M. Argüello, Advisor, Robert E. Dempski, Committee Member, Reeta Prusty Rao, Committee Member.
Subjects/Keywords: Metal transport; Metal homeostasis; P1B-ATPase
Patel, S. (2016). Functional Diversity of Homologous P1B-ATPases in Metal Homeostasis and Host-Microbe Interaction . (Doctoral Dissertation). Worcester Polytechnic Institute. Retrieved from etd-040416-140014 ; https://digitalcommons.wpi.edu/etd-dissertations/473
Patel, Sarju. “Functional Diversity of Homologous P1B-ATPases in Metal Homeostasis and Host-Microbe Interaction.” 2016. Doctoral Dissertation, Worcester Polytechnic Institute. Accessed January 21, 2021. etd-040416-140014 ; https://digitalcommons.wpi.edu/etd-dissertations/473.
Patel, Sarju. “Functional Diversity of Homologous P1B-ATPases in Metal Homeostasis and Host-Microbe Interaction.” 2016. Web. 21 Jan 2021.
Patel S. Functional Diversity of Homologous P1B-ATPases in Metal Homeostasis and Host-Microbe Interaction. [Internet] [Doctoral dissertation]. Worcester Polytechnic Institute; 2016. [cited 2021 Jan 21]. Available from: etd-040416-140014 ; https://digitalcommons.wpi.edu/etd-dissertations/473.
Patel S. Functional Diversity of Homologous P1B-ATPases in Metal Homeostasis and Host-Microbe Interaction. [Doctoral Dissertation]. Worcester Polytechnic Institute; 2016. Available from: etd-040416-140014 ; https://digitalcommons.wpi.edu/etd-dissertations/473
2. Matheou, Christian James. The influence of copper and zinc on the self-assembly of Amyloid-β from Alzheimer's disease.
URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/12901 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775159
► Alzheimer's disease is characterised by the misfolding and aggregation of a native peptide, Aβ, for which there are several isoforms, Aβ(1-40) being the most common,… (more)
▼ Alzheimer's disease is characterised by the misfolding and aggregation of a native peptide, Aβ, for which there are several isoforms, Aβ(1-40) being the most common, and Aβ(1-42) being most closely associated with Alzheimer's disease. Upon misfolding, Aβ self-associates to form a number of aggregate species. What triggers this process of misfolding-aggregation, and determines which aggregate species forms, is not known. One possible determinant is metal homeostasis, which in Alzheimer's patients is deregulated. Chapter 3 characterises how physiologically relevant levels of Cu2+ influence the misfolding pathway of Aβ. A ThT fluorescence assay found that Cu2+ is able to accelerate formation of Aβ(1-40) amyloid fibres; however, for Aβ(1-42), Cu2+ abolished fibre formation. Electron microscopy revealed that this is because Cu2+ stabilised Aβ(1-42) oligomers. These oligomers more readily disrupted lipid membranes than mature amyloid fibres, suggesting that the elevated levels of Cu2+ and the greater Aβ(1-42) synaptotoxicity in Alzheimer's disease may be related. Chapter 4 investigates the effect of Zn2+ on Aβ misfolding. Trace levels of Zn2+ are demonstrated to entirely abolish fibre growth, for both Aβ(1-40) and Aβ(1-42). It is found that that Zn2+ likely exerts such a dramatic effect through a rapid exchange of Zn2+ between Aβ molecules. Chapter 5 found that Cu2+ accelerated Aβ(1-40) fibre growth regardless of growth conditions, despite growth conditions influencing fibril morphology. It was also found that Cu2+ generated Aβ(1-40) fibres did not exhibit an altered stability, further suggesting that the effect of Cu2+ upon Aβ(1-40) is limited to fibril growth kinetics, in contrast to the effect of Cu2+ on Aβ(1-42), as well as the effect of Zn2+ upon either peptide. The present research has identified a diversity of significant interactions between Aβ, and Cu2+ and Zn2+, highlighting a potential role for these metal ions in Alzheimer's disease.
Subjects/Keywords: Biological and Chemical Sciences; Alzheimer's; metal homeostasis
Matheou, C. J. (2015). The influence of copper and zinc on the self-assembly of Amyloid-β from Alzheimer's disease . (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/12901 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775159
Matheou, Christian James. “The influence of copper and zinc on the self-assembly of Amyloid-β from Alzheimer's disease.” 2015. Doctoral Dissertation, Queen Mary, University of London. Accessed January 21, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/12901 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775159.
Matheou, Christian James. “The influence of copper and zinc on the self-assembly of Amyloid-β from Alzheimer's disease.” 2015. Web. 21 Jan 2021.
Matheou CJ. The influence of copper and zinc on the self-assembly of Amyloid-β from Alzheimer's disease. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2015. [cited 2021 Jan 21]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/12901 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775159.
Matheou CJ. The influence of copper and zinc on the self-assembly of Amyloid-β from Alzheimer's disease. [Doctoral Dissertation]. Queen Mary, University of London; 2015. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/12901 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775159
3. Choo, Xin Yi. Development of novel therapeutic approaches for treatment of Alzheimer's disease.
► AD is a complex disease, involving the perturbation of multiple interrelated biological pathways. Despite being the most common form of neurodegenerative disease, with the number… (more)
▼ AD is a complex disease, involving the perturbation of multiple interrelated biological pathways. Despite being the most common form of neurodegenerative disease, with the number of patients expected to increase drastically, the aetiology of AD remains unknown. Although genetic factors such as mutations in the APP and PSEN genes, which drive the overproduction of Aβ, are known to cause early on-set familial AD (EOFAD), majority of AD patients (> 95%) who develop clinical symptoms of AD later in life (i.e. late on-set AD (LOAD)) do not carry these mutations. Contrary to earlier assumptions that occurrence of LOAD was sporadic, GWAS and exome sequencing studies have identified genetic variants, in genes that are microglia specific, or highly expressed in microglia, that are associated with increased risk of LOAD, suggesting altered regulation of microglial functions to be involved in the pathogenesis of LOAD. Using microglia isolated from the 5xFAD mouse model of AD, we identified by bulk and single cell RNA-seq that plaque phagocytosing (X04+) and non-plaque phagocytosing (X04-) microglia are distinct microglial populations separable by their transcriptomic signature. Our study suggests that X04+ microglia are a homogenous population of microglia with a distinct gene expression profile associated with amyloid uptake. In contrary, X04- microglia are associated with an age-related transcriptomic profile and may be involved in the over-pruning of synapses in 5xFAD mice. We also demonstrated that microglia can undergo transcriptomic changes upon exposure to different environmental cues. Although therapeutic approaches that target different pathological features of AD have been evaluated, clinical translation of therapeutics has been very unsuccessful. This could be in part due to potential therapeutics targeting a single disease pathology. To identify new therapeutic candidates for the treatment of AD, this study also explored the use of metal-based compounds as a multi-targeting therapeutic strategy. Five novel metal-based compounds were screened to identify leading compounds that confer neuroprotective, metal-regulating and inflammation-modulating effects in a generic model of neuroinflammation. LM47 was identified as the only leading compound that exerted inflammatory-modulating activity through copper-associated action. Further testing of LM47 showed that the compound was well-tolerated in vivo. However, data by pharmacokinetic study and ICP-MS suggest that the copper free ligand LM46, and not LM47, acts as the active compound in vivo. Treatment of 5xFAD mice with LM46 increased the proportion of X04+ microglia in brain. However, Both LM46 and LM47 treatment of 5xFAD mice induced increased brain Aβ plaque load in the animals. Taken together, findings from our study suggest that improved targeting of specific microglia sub-population in AD could confer therapeutic outcomes.
Subjects/Keywords: Alzheimer's disease; copper; metal homeostasis; neuroinflammtion; microglia
Choo, X. Y. (2018). Development of novel therapeutic approaches for treatment of Alzheimer's disease . (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/216470
Choo, Xin Yi. “Development of novel therapeutic approaches for treatment of Alzheimer's disease.” 2018. Doctoral Dissertation, University of Melbourne. Accessed January 21, 2021. http://hdl.handle.net/11343/216470.
Choo, Xin Yi. “Development of novel therapeutic approaches for treatment of Alzheimer's disease.” 2018. Web. 21 Jan 2021.
Choo XY. Development of novel therapeutic approaches for treatment of Alzheimer's disease. [Internet] [Doctoral dissertation]. University of Melbourne; 2018. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/11343/216470.
Choo XY. Development of novel therapeutic approaches for treatment of Alzheimer's disease. [Doctoral Dissertation]. University of Melbourne; 2018. Available from: http://hdl.handle.net/11343/216470
4. Aksoy, Emre. Arabidopsis Thaliana CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-Like1 (CPL1) Mediates Responses to Iron Deficiency and Cadmium Toxicity.
Degree: PhD, Molecular and Environmental Plant Sciences, 2014, Texas A&M University
► The expression of genes that control iron (Fe) uptake and distribution (i.e., Fe utilization- related genes) is under a strict regulation. Fe deficiency strongly induces… (more)
▼ The expression of genes that control iron (Fe) uptake and distribution (i.e., Fe utilization- related genes) is under a strict regulation. Fe deficiency strongly induces Fe utilization- related gene expression; however, little is known about the mechanisms that regulate this response in plants. In this dissertation, a RNA metabolism factor, RNA POLYMERASE II CTD-PHOSPHATASE-LIKE1 (CPL1) was shown to localize to the root stele, and to be involved in the regulation of Fe deficiency responses in Arabidopsis thaliana. An analysis of multiple cpl1 alleles established that cpl1 mutations enhanced transcriptional responses of Fe utilization-related genes, e.g. IRON-REGULATED TRANSPORTER1 (IRT1), to low Fe availability. In addition to the lower Fe content in the roots, but higher Fe content in the shoots of cpl1-2 plants, the root growth of cpl1-2 showed improved tolerance to Fe deficiency. Genetic data indicated that cpl1-2 likely activates Fe deficiency responses upstream of both FE–DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT)- dependent and -independent signaling pathways. Interestingly, various osmotic stress/ABA-inducible genes were up-regulated in cpl1-2, and the expression of some ABA-inducible genes was controlled by Fe availability. Unlike Fe, accumulation of the heavy-metal cadmium (Cd) in plants is toxic and it is absorbed by the roots due to the low selectivity of metal transporters such as AtIRT1. In this dissertation, CPL1 was also shown to regulate the transcriptional responses to Cd toxicity. cpl1-2 showed higher tolerance to the Cd toxicity by enhancing the root-to-shoot translocation of Cd by an unknown mechanism. A knowledge-based screening resulted in identification of a putative metal transporter, OLIGOPEPTIDE TRANSPORTER (OPT), which was highly induced in cpl1-2 upon exposure to Cd. OPT was localized to the plastids, indicating a role of plastids in Cd transport and accumulation. The root growth of opt mutants showed higher tolerance to the Cd toxicity, and the mutants accumulated less Cd, Fe and Zn, indicating the involvement of OPT in the transport of these metals. This presented dissertation suggests that 1) CPL1 functions as a negative regulator of the Fe deficiency signaling at the crosstalk with a branch of the osmotic stress/ABA signaling pathway, and 2) CPL1 regulates the Cd distribution in plants by repressing the expression of OPT. Advisors/Committee Members: Koiwa, Hisashi (advisor), Zhu-Salzman, Keyan (committee member), Pepper, Alan E (committee member), Hirschi, Kendal D (committee member), Finlayson, Scott A (committee member).
Subjects/Keywords: Arabidopsis; cadmium; iron; metal; CTD; RNA metabolism; microarray; homeostasis
Aksoy, E. (2014). Arabidopsis Thaliana CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-Like1 (CPL1) Mediates Responses to Iron Deficiency and Cadmium Toxicity . (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/152841
Aksoy, Emre. “Arabidopsis Thaliana CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-Like1 (CPL1) Mediates Responses to Iron Deficiency and Cadmium Toxicity.” 2014. Doctoral Dissertation, Texas A&M University. Accessed January 21, 2021. http://hdl.handle.net/1969.1/152841.
Aksoy, Emre. “Arabidopsis Thaliana CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-Like1 (CPL1) Mediates Responses to Iron Deficiency and Cadmium Toxicity.” 2014. Web. 21 Jan 2021.
Aksoy E. Arabidopsis Thaliana CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-Like1 (CPL1) Mediates Responses to Iron Deficiency and Cadmium Toxicity. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1969.1/152841.
Aksoy E. Arabidopsis Thaliana CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-Like1 (CPL1) Mediates Responses to Iron Deficiency and Cadmium Toxicity. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/152841
5. Ebanks, Sue C. The Common Pond Snail Lymnaea stagnalis: Extracellular Fluid Recovery in Adults and Calcification and Lead Sensitivity During Embryonic Development.
Degree: PhD, Marine Biology and Fisheries (Marine), 2010, University of Miami
► Freshwater organisms are known to maintain hyperosmotic internal conditions despite outward diffusive loss of ions. The freshwater common pond snail Lymnaea stagnalis faces this… (more)
▼ Freshwater organisms are known to maintain hyperosmotic internal conditions despite outward diffusive loss of ions. The freshwater common pond snail Lymnaea stagnalis faces this challenge while additionally attaining the necessary ions for calcification. These are the first documented assessments of the time and mode of recovery for ions lost due to full-body withdrawal in adults of this species. Additionally, this document reports on the physiological and developmental onset of embryonic calcification and the commencement of active acquisition of shell-forming ions from the surrounding environment. The effect of water chemistry and lead (Pb) exposure on embryonic growth, development, and calcium (Ca2+) acquisition was also tested. Pharmacological and water chemistry manipulations were used to determine mechanisms for embryonic Ca2+ and HCO3-/CO32- acquisition and the sensitivity of those pathways. Lastly, L. stagnalis, was shown to have a lowest effective concentration of -1 using net Ca2+ uptake, growth, and developmental endpoints in laboratory and natural waters. This is the lowest effective concentration observed for any organism to date. One of the most insightful findings reported here is the interconnectedness of the pathways for acquisition of Na+ and Ca2+ through endogenous production of H+ and HCO3- via carbonic anhydrase-catalyzed hydration of metabolic CO2. The combination of high demand for Ca2+ throughout early life stages and periodic acute demands for Na+ recovery following extracellular fluid loss apparently causes L. stagnalis to be highly sensitive to changes in water chemistry, including [Pb] in the embryos, and possibly pH. The findings reported here warn of the need to establish freshwater environmental indicators and consider raising awareness of the threat of freshwater acidification, which may be greater than that of ocean acidification. Advisors/Committee Members: Martin Grosell, Christopher M. Wood, David Letson, Christopher Langdon, Lynne Fieber.
Subjects/Keywords: Homeostasis; Calcium; Water Chemistry; Invertebrate; Metal Toxicology; Freshwater Physiology
Ebanks, S. C. (2010). The Common Pond Snail Lymnaea stagnalis: Extracellular Fluid Recovery in Adults and Calcification and Lead Sensitivity During Embryonic Development . (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/658
Ebanks, Sue C. “The Common Pond Snail Lymnaea stagnalis: Extracellular Fluid Recovery in Adults and Calcification and Lead Sensitivity During Embryonic Development.” 2010. Doctoral Dissertation, University of Miami. Accessed January 21, 2021. https://scholarlyrepository.miami.edu/oa_dissertations/658.
Ebanks, Sue C. “The Common Pond Snail Lymnaea stagnalis: Extracellular Fluid Recovery in Adults and Calcification and Lead Sensitivity During Embryonic Development.” 2010. Web. 21 Jan 2021.
Ebanks SC. The Common Pond Snail Lymnaea stagnalis: Extracellular Fluid Recovery in Adults and Calcification and Lead Sensitivity During Embryonic Development. [Internet] [Doctoral dissertation]. University of Miami; 2010. [cited 2021 Jan 21]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/658.
Ebanks SC. The Common Pond Snail Lymnaea stagnalis: Extracellular Fluid Recovery in Adults and Calcification and Lead Sensitivity During Embryonic Development. [Doctoral Dissertation]. University of Miami; 2010. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/658
6. Chandrapalan, Theanuga. Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio).
Degree: MSc -MS, Biology, 2019, York University
URL: https://yorkspace.library.yorku.ca/xmlui/handle/10315/36794
► Iron (Fe) is an essential trace metal for development; however, its level in the body must be maintained within physiological range. In the present study,… (more)
▼ Iron (Fe) is an essential trace metal for development; however, its level in the body must be maintained within physiological range. In the present study, the effects of dietary Fe on growth, trace metal homeostasis, and the expression of various metal transporting genes were investigated during development in zebrafish (Danio rerio). The results demonstrated that growth and whole body Fe content were substantially higher in 14 dpf larvae fed high Fe diets. Interestingly, prolonged exposure to high Fe increased mortality but did not affect the levels of Fe and other trace metals (e.g., Zn2+, Cu2+, Mn2+, Ni2+) in 28 dpf larvae. Molecular analysis revealed that exposure to high dietary Fe induced differential changes in the mRNA expression levels of various metal transporters (e.g., dmt1, zip8, and zip14). These findings suggested that the maintenance of metal homeostasis following Fe exposure was likely associated with the dynamic regulation of metal transporting proteins. Advisors/Committee Members: Kwong, Raymond (advisor).
Subjects/Keywords: Biology; Iron; Metal homeostasis; Dietary exposure; Development; Zebrafish
Chandrapalan, T. (2019). Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio) . (Masters Thesis). York University. Retrieved from https://yorkspace.library.yorku.ca/xmlui/handle/10315/36794
Chandrapalan, Theanuga. “Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio).” 2019. Masters Thesis, York University. Accessed January 21, 2021. https://yorkspace.library.yorku.ca/xmlui/handle/10315/36794.
Chandrapalan, Theanuga. “Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio).” 2019. Web. 21 Jan 2021.
Chandrapalan T. Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio). [Internet] [Masters thesis]. York University; 2019. [cited 2021 Jan 21]. Available from: https://yorkspace.library.yorku.ca/xmlui/handle/10315/36794.
Chandrapalan T. Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio). [Masters Thesis]. York University; 2019. Available from: https://yorkspace.library.yorku.ca/xmlui/handle/10315/36794
7. Lacasse, Michael Joseph. Investigation of Escherichia coli [NiFe]-Hydrogenase Maturation.
[NiFe]-hydrogenases catalyze the reversible oxidation of hydrogen gas at a bimetallic active site and are important enzymes in bacteria and archaea for anaerobic growth and… (more)
[NiFe]-hydrogenases catalyze the reversible oxidation of hydrogen gas at a bimetallic active site and are important enzymes in bacteria and archaea for anaerobic growth and pathogenesis. The maturation of [NiFe]-hydrogenase requires at least seven dedicated accessory proteins to assemble and insert the components of the NiFe(CN)2CO catalytic site. The penultimate maturation step is the delivery of nickel to a primed hydrogenase precursor protein, a process that is accomplished by the metallochaperone proteins HypA, HypB, and SlyD. This delivery process is supported by proteins that import, export, regulate, and store nickel to ensure a sufficient supply while also mitigating the innate toxicity of this transition metal. In this work, nickel delivery to the [NiFe]-hydrogenase in Escherichia coli was examined using microbiological, biochemical, spectroscopic, and computational methods. The results demonstrate that protein-protein interactions between the metallochaperones afford layers of nickel selectivity. The protein complexes HypA-HypB and SlyD-HypB are modulated by the GTPase cycle of HypB and mediate the selective release of nickel over zinc. In addition, characterization of the metal-binding sites of HypA and HypB revealed different binding modalities, suggesting distinct acquisition and release mechanisms for these metallochaperones. This thesis also describes the development and employment of a high-throughput whole-cell [NiFe]-hydrogenase assay. The assay was used to screen the Keio collection of single gene deletion strains of E. coli and uncovered, for the first time, eutK as a component of the nickel delivery pathway and nickel homeostasis. The assay was also used to determine extracellular nickel concentrations required to bypass the nickel uptake and delivery processes to validate those systems as potential therapeutic targets, setting the stage for the search for small molecules that inhibit the biosynthesis of [NiFe]-hydrogenase. Together, this work gives insight into several aspects of the crucial nickel delivery process that bacteria use to produce [NiFe]-hydrogenase.
Advisors/Committee Members: Zamble, Deborah B, Chemistry.
Subjects/Keywords: Escherichia coli; Hydrogenase; Metal Homeostasis; Metallochaperones; Nickel; 0487
Lacasse, M. J. (2019). Investigation of Escherichia coli [NiFe]-Hydrogenase Maturation . (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/102758
Lacasse, Michael Joseph. “Investigation of Escherichia coli [NiFe]-Hydrogenase Maturation.” 2019. Doctoral Dissertation, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/102758.
Lacasse, Michael Joseph. “Investigation of Escherichia coli [NiFe]-Hydrogenase Maturation.” 2019. Web. 21 Jan 2021.
Lacasse MJ. Investigation of Escherichia coli [NiFe]-Hydrogenase Maturation. [Internet] [Doctoral dissertation]. University of Toronto; 2019. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/102758.
Lacasse MJ. Investigation of Escherichia coli [NiFe]-Hydrogenase Maturation. [Doctoral Dissertation]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/102758
8. McCormick, Sean P. The Application of LC-ICP-MS to Study Metal Ion Homeostasis in Biological Systems.
Degree: PhD, Chemistry, 2014, Texas A&M University
► Eukaryotic cells contain low-molecular-mass metal complexes (LMMMCs), defined as having masses between 200 – 10,000 Da, but these so-called labile or chelatable metal pools are… (more)
▼ Eukaryotic cells contain low-molecular-mass metal complexes (LMMMCs), defined as having masses between 200 – 10,000 Da, but these so-called labile or chelatable metal pools are poorly defined in terms of structures and functions. LMMMCs are thought to participate in metal-ion regulation, trafficking, storage and/or signaling in cells. These cellular processes are often dysfunctional in metal-associated diseases. The objective of these studies was to detect and characterize LMMMCs in eukaryotic cells, organelles and tissues. A novel liquid chromatography system in a cold inert-atmosphere glove box was interfaced with an in-line inductively coupled plasma mass spectrometer, and this LC-ICP-MS system was used to detect LMMMCs in yeast cells, mitochondria, and vacuoles as well as in mouse brain and liver cells and mitochondria. In each biological system, this separations technique was applied to detect numerous LMMMCs. The molecular mass and concentration of such species were estimated. In yeast, the previously reported mismetallation of MnSOD2 was examined in the mutant strain Δmtm1. A combination of SEC and AEX chromatography revealed that the degree of mismetallation of the SOD2 protein, in which Fe replace Mn in the active site, was no greater in Δmtm1 cells than in WT cells. The mitochondria of such mutant cells did exhibit an intense chromatography peak of Mn corresponding to at mass of 2000 – 3000 Da. Mitochondria from WT cells exhibited a similar species, but at much lower intensity. This was the only Mn species present, suggesting that it was the used to metallate apo-SOD2. Mitochondria isolated from WT yeast cells contained 6 Co, 3 Cu, 2 Mn, 5 Fe and 3 Zn LMMMCs and approximately 6 P- and S- LLM species. Some of the P- and S- LMMCs probably arose from compounds like ATP, ADP, etc. Molecular masses of the LMM Cu peaks were higher (> 5 kDa) than for the LMM complexes of other transition metals. Zinc, Mn, and Fe had multiple species of interest which demonstrate the presence and labiality of the metals in pools. The same separation system was utilized to examine mice brain LMM extracts were found to contain > 30 LMMMCs. Eleven Co, 2 Cu, 5 Mn, 4 Mo, 3 Fe and 2 Zn LLM complexes were detected. Most Cu and Zn complexes appeared to be protein-bound with masses ranging from 4–20 kDa. In these systems, Co was the only metal for which the aqueous complex was reproducibly observed. A second mouse study used the LC-ICP-MS system to examine the forms of iron present in mouse plasma. Chromatograms exhibited ~6 Fe-associated peaks that were assigned to ferritin, transferrin, and hemopexin, respectively; the other 3 peaks could not be assigned. The LC-ICP-MS experiment demonstrates that numerous Fe-containing species coexist with transferrin in healthy WT mouse plasma. Advisors/Committee Members: Lindahl, Paul A (advisor), Barondeau, David P (committee member), Hilty, Christian (committee member), Pellois, Jean-Philippe (committee member).
Subjects/Keywords: Labile Metal Pools; Metal Pools; LC-ICP-MS; Metal Speciation; Yeast; Mice Brain; mtm1p; MnSOD; metal trafficking; metal homeostasis; Bioanalytical; Manganese Pool; Low Molecular Mass Metal Complexes; LMM; LMMMCs
McCormick, S. P. (2014). The Application of LC-ICP-MS to Study Metal Ion Homeostasis in Biological Systems . (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/154123
McCormick, Sean P. “The Application of LC-ICP-MS to Study Metal Ion Homeostasis in Biological Systems.” 2014. Doctoral Dissertation, Texas A&M University. Accessed January 21, 2021. http://hdl.handle.net/1969.1/154123.
McCormick, Sean P. “The Application of LC-ICP-MS to Study Metal Ion Homeostasis in Biological Systems.” 2014. Web. 21 Jan 2021.
McCormick SP. The Application of LC-ICP-MS to Study Metal Ion Homeostasis in Biological Systems. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1969.1/154123.
McCormick SP. The Application of LC-ICP-MS to Study Metal Ion Homeostasis in Biological Systems. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/154123
9. Avalos, Ana M. HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana.
Degree: MS, 2004, Worcester Polytechnic Institute
URL: etd-0429104-112415 ; https://digitalcommons.wpi.edu/etd-theses/492
► Metal homeostasis in plants is regulated by diverse mechanisms that act together to maintain optimal metal ion concentrations inside the cell. P1B-ATPases are heavy metal… (more)
▼ Metal homeostasis in plants is regulated by diverse mechanisms that act together to maintain optimal metal ion concentrations inside the cell. P1B-ATPases are heavy metal transport ATPases that are likely to be related to these processes. The sequencing of the genome of Arabidopsis thaliana revealed the presence of eight putative P1B-ATPases, HMA1-8. The main goal in this work is to characterize of the role of P1B-ATPases in plant metal homeostasis. Toward this goal, the P1B-ATPases HMA1 and HMA6 from Arabidopsis thaliana were cloned from leaves and sequenced. Results from RT-PCR experiments show ubiquitous expression in planta of this two ATPases, except for HMA1 that does not express in roots. Upon Cu2+ exposure during growth, expression of HMA6 increases in seedlings. HMA1 expression increases when seedlings are grown in high Cu2+ and Co2+ media, and decreases when grown in high concentrations of Zn2+ and Ni2+. hma1-1 plants have smaller size and less chlorophyll content than WT plants. Growth is affected in hma1-1 seedlings when grown in Zn2+, Mn2+, Fe2+, Co2+ and Cu2+ deficient media, or when these metals are in excess. Moreover, hma1-1 plants show an increase in Zn2+, Mn2+ and Fe2+ content in whole plants compared to WT plants. Mutant plants also show increased levels of HMA3 and HMA4 transcripts (Zn2+/Cd2+/Pb2+ P1B-ATPases), upregulation of metallothioneins 1a and 2b, downregulation of metallothionein 1c, and a decrease in the phytochellatin synthases 1 and 2 transcripts, compared to WT plants. Homozygous for mutation in HMA6 seems to be lethal, given that none was recovered after screening. These results indicate HMA1 and HMA6 as essential components of plant metal homeostasis in Arabidopsis thaliana. Advisors/Committee Members: José M. Argüello, Advisor, ;.
Subjects/Keywords: plant metal homeostasis; P1B ATPases; Metal ions; Homeostasis; Carrier proteins; Arabidopsis thaliana
Avalos, A. M. (2004). HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana . (Thesis). Worcester Polytechnic Institute. Retrieved from etd-0429104-112415 ; https://digitalcommons.wpi.edu/etd-theses/492
Avalos, Ana M. “HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana.” 2004. Thesis, Worcester Polytechnic Institute. Accessed January 21, 2021. etd-0429104-112415 ; https://digitalcommons.wpi.edu/etd-theses/492.
Avalos, Ana M. “HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana.” 2004. Web. 21 Jan 2021.
Avalos AM. HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana. [Internet] [Thesis]. Worcester Polytechnic Institute; 2004. [cited 2021 Jan 21]. Available from: etd-0429104-112415 ; https://digitalcommons.wpi.edu/etd-theses/492.
Avalos AM. HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana. [Thesis]. Worcester Polytechnic Institute; 2004. Available from: etd-0429104-112415 ; https://digitalcommons.wpi.edu/etd-theses/492
10. Wu, Tsung-meng. Gene expression in marine macroalga Ulva fasciata Delile against excess copper toxicity.
Degree: PhD, Marine Biology, 2009, NSYSU
► This is the first research by using suppression subtractive hybridization (SSH) to analysis the gene expression in marine macroalga Ulva fasciata Delile against excess copper… (more)
▼ This is the first research by using suppression subtractive hybridization (SSH) to analysis the gene expression in marine macroalga Ulva fasciata Delile against excess copper toxicity, and it gives us a comprehensive understanding of the tolerant mechanism while macroalgae face to the excess copper. Suppression subtractive hybridization was used to identify genes differentially expressed following exposure to 50 μM CuSO4 for 6- 12h in a marine macroalga Ulva fasciata Delile. In this work, 69 genes were identified, of which 55 were up-regulated and 14 were down-regulated. According to the database of Gene Ontology (GO), these genes were classified into 10 categories as follows: 1. Transcription; 2. Translation, ribosomal structure and biogenesis; 3. Posttranslational modification, protein turnover, chaperones; 4. Photosynthesis; 5. Cell redox homeostasis; 6. Stress; 7. Metabolism; 8. Energy production and conversion; 9. Transport; 10. Function unknown. According to the results, we suggest that the responses of U. fasciata against excess copper toxicity are mainly through increase of the energy production for providing sufficient energy to many metabolic pathways, and control of the Fe homeostasis and redox form of thiol groups for maintaining the cellular redox homeostasis, moreover, expression of photosynthetic genes for letting the photosynthesis work. In addition, to scavenge the ROS is by expression of stress-related genes, meanwhile, the proteins, DNA and lipids damaged by ROS (reactive oxygen species) and copper are repaired by expression of the other categorical genes. Over and above, the genes expressing in the metabolism category might maintain the amino acids homeostasis and increase the purine content, and subsequently increase the tolerant capacity of U. fasciata against excess copper toxicity. In addition, the concentrations of antioxidants and the activities and gene expression of antioxidant enzymes were determined in Ulva fasciata Delile by a 4-day exposure to 0, 5, 10, 20 and 50 μM CuSO4. These results demonstrate that the maintenance of antioxidant homeostasis and the induction of activities of antioxidant enzymes via enhanced gene expression are used by U. fasciata to cope with the Cu-induced oxidative stress, but the defense capacity cannot sufficiently alleviate oxidative damage occurring under the condition of higher Cu concentrations. Moreover, according to the results from the expression of genes involved in the control of redox homeostasis and antioxidant defense was studied in macroalga Ulva fasciata Delile in response to CuSO4 (5 and 50 μM) and ROS (H2O2 and O2Ë-), we suggest that ROS involved in up-regulation of antioxidant defense-related genes and the expression of genes of antioxidant defense enzymes and UfMsrA (methionine sulfoxide reductase A) are associated with long-term adaptation of U. fasciata to Cu excess and transcription of redox- related genes and UfGr (glutathione reductase) is up-regulated for short-term acclimation. Promoters play a key role in regulating gene… Advisors/Committee Members: Hao-Jen Huang (chair), Zin-Huang Liu (chair), Kuo-Chen Yeh (chair), Ming-Tsair Chan (chair), Yi-Ting Hsu (chair), Tse-Min Lee (committee member), Ching-Huei Kao (chair).
Subjects/Keywords: Ulva fasciata; copper; heavy metal; oxidative stress; redox homeostasis; gene expression; suppression subtractive hybridization
Wu, T. (2009). Gene expression in marine macroalga Ulva fasciata Delile against excess copper toxicity . (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-1228109-120140
Wu, Tsung-meng. “Gene expression in marine macroalga Ulva fasciata Delile against excess copper toxicity.” 2009. Doctoral Dissertation, NSYSU. Accessed January 21, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-1228109-120140.
Wu, Tsung-meng. “Gene expression in marine macroalga Ulva fasciata Delile against excess copper toxicity.” 2009. Web. 21 Jan 2021.
Wu T. Gene expression in marine macroalga Ulva fasciata Delile against excess copper toxicity. [Internet] [Doctoral dissertation]. NSYSU; 2009. [cited 2021 Jan 21]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-1228109-120140.
Wu T. Gene expression in marine macroalga Ulva fasciata Delile against excess copper toxicity. [Doctoral Dissertation]. NSYSU; 2009. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-1228109-120140
11. Tebo, Alison G. De Novo Designed Metallopeptides to Investigate Metal Ion Homeostasis, Electron Transfer, and Redox Catalysis.
Degree: PhD, Chemical Biology, 2015, University of Michigan
► Protein design is a powerful way to interrogate the basic requirements for function of metal sites by systematically incorporating elements important for function. Single-stranded three-helix… (more)
▼ Protein design is a powerful way to interrogate the basic requirements for function of metal sites by systematically incorporating elements important for function. Single-stranded three-helix bundles with either thiolate-rich sites for spectroscopic characterization and electron transfer, or histidine-rich sites for redox catalysis are described. Using a previous design, two constructs were designed to incorporate a fourth cysteine residue to investigate thiolate-rich sites involved in metal ion homeostasis and electron transfer. Rational re-design replaced a putative coordinating histidine with a cysteine. A second construct embedded a CXXC binding motif into the helical scaffold. These two constructs show different UV-visisble, 113Cd NMR, and 111mCd PAC, which indicate that they form different proportions of CdS3O and CdS4. The spectroscopy of these sites sheds light on how Cd(II) bindis to CadC and suggests a dynamic site in fast exchange with the solvent. Previous attempts at the design of a rubredoxin site have focused on reproducing the peptide fold around or using flexible loop regions to define the site in addition to canonical CXXC motifs. However, the use of CXXC motifs embedded in an α-helical scaffold produces a rubredoxin site that reproduces the Mössbauer, MCD, and EPR of rubredoxin without the use of loop regions. This successful design is the largest deviation from consensus rubredoxin and zinc finger folds reported. Electron transfer rates through a de novo designed scaffold were studied by the design and synthesis of a ruthenium trisbipyridine derivative appended to an exterior cysteine residues. A redox-active tyrosine in the 70th position is implicated as a relay amino acid from the iron center and absence of the tyrosine decreases the rate of electron transfer from the metal site. This is the first photo-generated tyrosine radical in a designed protein. A construct, which was previously reported for CO2 hydration, is substituted with copper and its spectroscopic and nitrite reductase activity are studied. This is the first demonstration of nitrite reductase activity in a single-stranded designed peptide. This thesis provides insight into designed proteins and their applications and lays the groundwork for further studies to progress towards a unified multifunctional redox protein. Advisors/Committee Members: Aukauloo, Ally (committee member), Pecoraro, Vincent L. (committee member), Fierke, Carol A. (committee member), Lehnert, Nicolai (committee member), Ballou, David P. (committee member).
Subjects/Keywords: metal homeostasis; electron transfer protein; laser flash photolysis; tyrosine radical; nitrite reductase; Chemistry; Science
Tebo, A. G. (2015). De Novo Designed Metallopeptides to Investigate Metal Ion Homeostasis, Electron Transfer, and Redox Catalysis. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/113513
Tebo, Alison G. “De Novo Designed Metallopeptides to Investigate Metal Ion Homeostasis, Electron Transfer, and Redox Catalysis.” 2015. Doctoral Dissertation, University of Michigan. Accessed January 21, 2021. http://hdl.handle.net/2027.42/113513.
Tebo, Alison G. “De Novo Designed Metallopeptides to Investigate Metal Ion Homeostasis, Electron Transfer, and Redox Catalysis.” 2015. Web. 21 Jan 2021.
Tebo AG. De Novo Designed Metallopeptides to Investigate Metal Ion Homeostasis, Electron Transfer, and Redox Catalysis. [Internet] [Doctoral dissertation]. University of Michigan; 2015. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2027.42/113513.
Tebo AG. De Novo Designed Metallopeptides to Investigate Metal Ion Homeostasis, Electron Transfer, and Redox Catalysis. [Doctoral Dissertation]. University of Michigan; 2015. Available from: http://hdl.handle.net/2027.42/113513
12. Han, Thi-Hong-Liên. Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress.
Degree: Docteur es, Chimie. Physico-Chimie, 2016, Sorbonne Paris Cité
URL: http://www.theses.fr/2016USPCC288
La frataxine est une protéine mitochondriale bien conservée de la bactérie à l’homme. La déficience de la frataxine chez l’homme entraine une maladie neurodégénérative grave,… (more)
La frataxine est une protéine mitochondriale bien conservée de la bactérie à l’homme. La déficience de la frataxine chez l’homme entraine une maladie neurodégénérative grave, appelée Ataxie de Friedreich. Cette protéine a été découverte dans les années 90s et depuis sa fonction physiologique exacte n’est toujours pas connue. La frataxine joue un rôle important dans la biosynthèse des centres Fe-S dans l’homéostasie du fer et/ou dans la protection contre le stress oxydant. Dans cette thèse, nous nous intéressons aux interactions entre la protéine et d’autres molécules, comme certains métaux mitochondriaux ou protéines pour mieux comprendre la fonction de la frataxine dans la cellule. Lors de ce travail, la frataxine de levure (Yfh1) a été synthétisée par la technique de l’ADN recombinant, puis purifiée pour les études physico-chimiques. La flavohémoglobine (Yhb1)qui joue le rôle important dans la détoxification de NO (un agent du stress oxydatif et nitrosatif) a été aussi exprimée et purifiée selon le même principe. Ensuite, nous avons étudié la thermodynamique et la cinétique de la complexation de Yfh1 par les métaux mitochondriaux comme Fe, Cu, Mn, Zn, ainsi qu’avec les protéines impliquées dans le système antioxydant comme les superoxydes dismutases, CuZnSOD et MnSOD, et la flavohémoglobine. Ces résultats montrent tout d’abord que Yfh1 interagit avec tous les métaux mitochondriaux,néanmoins elle présente une meilleure affinité pour le cuivre et le manganèse. Par la suite, nous mettons en évidence le rôle remarquable de la frataxine dans le système antioxydant. Nous attribuons ainsi à la frataxine un rôle de protéine multifonctionnelle : « régulateur » dans le métabolisme des métaux.
The frataxin is a mitochondrial protein which is highly conserved during the evolution. The deficiency of frataxinin human induces a neurodegenerative disease: Friedreich’s ataxia. This protein was discovered in the nineties.However, its functions are always opened questions. It has been shown that frataxin participates in the assemblyof Fe-S cluster, as well as the iron homeostasis and cellular antioxidant system. The interactions between frataxinand others molecules, such as metals or proteins, are necessary for a better understanding of protein’s functions.In this work, we synthesized a yeast frataxin homologue (Yfh1) by DNA recombinant technique, and thenpurified it for cell free studies. Yeast flavohemoglobin (Yhb1), which is responsible for the detoxification of NO(an oxidative and nitrosative stress agent), was also isolated. We started by determining the thermodynamics andkinetics of the physiological interaction between Yfh1 and mitochondrial metals, such as Fe, Cu, Mn and Zn, aswell as the interaction with the gatekeepers in the anti-oxidative stress such as superoxide dismutases, CuZnSOD& MnSOD, and Yhb1. We underline here, in the first part the unspecific interaction of Yfh1 with mitochondrialmetals, and more especially the higher affinity of Yfh1 for copper and manganese than for iron. We also confirmthe remarkable…
Advisors/Committee Members: Ha-Duong, Nguyêt-Thanh (thesis director), El Hage Chahine, Jean-Michel (thesis director).
Subjects/Keywords: Homéostasie métallique; Métaux mitochondriaux; Relaxation chimique; Metal homeostasis; Mitochondrial metals; Relaxation chemistry
Han, T. (2016). Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress . (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2016USPCC288
Han, Thi-Hong-Liên. “Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress.” 2016. Doctoral Dissertation, Sorbonne Paris Cité. Accessed January 21, 2021. http://www.theses.fr/2016USPCC288.
Han, Thi-Hong-Liên. “Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress.” 2016. Web. 21 Jan 2021.
Han T. Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2016. [cited 2021 Jan 21]. Available from: http://www.theses.fr/2016USPCC288.
Han T. Etudes de la fonction de la frataxine : relations avec l'homéostasie métallique et le stress oxydant. : Functional studies of Frataxin : relations with metal homeostasis and oxidatives stress. [Doctoral Dissertation]. Sorbonne Paris Cité; 2016. Available from: http://www.theses.fr/2016USPCC288
13. Tian, Hui. Phloem functions revealed by the nakr1-1 mutant.
Degree: Plant Biological Sciences, 2011, University of Minnesota
URL: http://purl.umn.edu/101986
► Na+ is a non- essential element for plant growth. Na+ accumulation within plants, especially the shoot tissue causes osmotic stress and Na+-specific toxicity that threatens… (more)
▼ Na+ is a non- essential element for plant growth. Na+ accumulation within plants, especially the shoot tissue causes osmotic stress and Na+-specific toxicity that threatens plant survival and reduces crop yield. The control of Na+ accumulation in the shoot is mainly at the root level, by regulating net Na+ uptake into roots and Na+ transport from root to the shoot. My thesis work is mainly on the characterization of a fast neutron mutagenized Arabidopsis mutant, nakr1-1, that accumulates Na+ and K+ in the shoot tissue and has pleiotrophic developmental phenotypes (including short roots, late flowering and loss of apical dominance). Using traditional mapping together with DNA- chip based mapping, a 7-bp deletion was identified that caused loss- of- function mutation of a gene encoding a putative heavy-metal-binding protein. The metalbinding feature of the protein was confirmed by elemental analysis of maltose binding protein (MBP)- tagged NaKR1 expressed and purified from Escherichia coli. AtNaKR1 was specifically expressed in the phloem companion cells. NaKR1 protein was phloem mobile and unloaded at the phloem terminal into the proximal root meristem region. nakr1-1 mutation caused severe phloem function defects as demonstrated by less efficient 14C- sucrose loading and starch accumulation in rosette leaves. Phloem function defects were also responsible for the Na+/K+ accumulation in the shoot tissue based on the reciprocal grafting results together with ICP- MS analyses. Moreover elemental analysis of xylem sap indicated Na+ and K+ accumulation phenotypes were not caused by increased root- to- shoot transport of Na+ and K+. nakr1-1 mutation affects root meristem maintenance after germination as revealed by study of root meristem size, cell pattern and starch accumulation in root columella cells and quiescent center activity. My work provided evidence that phloem recirculation plays more important roles than had been suggested by previous literature in controlling shoot Na+ accumulation. Understanding how Na+ and K+ redistribution is regulated might have potential application in improving salinity tolerance of crop plants and the improvement of seed quality.
Subjects/Keywords: Companion cell; Heavy metal binding protein; Na+/ K+ homeostasis; Mobile; Phloem specific; Root Meristem
Tian, H. (2011). Phloem functions revealed by the nakr1-1 mutant. (Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/101986
Tian, Hui. “Phloem functions revealed by the nakr1-1 mutant.” 2011. Thesis, University of Minnesota. Accessed January 21, 2021. http://purl.umn.edu/101986.
Tian, Hui. “Phloem functions revealed by the nakr1-1 mutant.” 2011. Web. 21 Jan 2021.
Tian H. Phloem functions revealed by the nakr1-1 mutant. [Internet] [Thesis]. University of Minnesota; 2011. [cited 2021 Jan 21]. Available from: http://purl.umn.edu/101986.
Tian H. Phloem functions revealed by the nakr1-1 mutant. [Thesis]. University of Minnesota; 2011. Available from: http://purl.umn.edu/101986
14. Hunsaker, Elizabeth. Insight into the Role of Metal Homeostasis in Fungal Adaptation to Drug Stress .
Degree: 2019, Duke University
► Maintenance of metal homeostasis is critical to cell survival due to the multitude of cellular processes that depend on one or more metal cofactors.… (more)
▼ Maintenance of metal homeostasis is critical to cell survival due to the multitude of cellular processes that depend on one or more metal cofactors. We show that the opportunistic fungal pathogen Candida albicans becomes sensitized to both Cu limitation and Cu elevation during exposure in liquid culture to the antifungal drug fluconazole, a widely prescribed antifungal agent. Cu supplementation reduces tolerance of C. albicans to fluconazole in a way that does not require formation of a Cu–fluconazole complex. Rather, our data point to a less obvious relationship between drug stress and Cu availability that gives rise to metal-mediated outcomes of drug treatment. qRT-PCR, EPR, fluorescence, and ICP-MS studies demonstrate that C. albicans extensively remodels its metal homeostasis networks to respond to treatment with fluconazole. These adaptation strategies include increased Cu import and storage, increased retention of Fe, Mn, and Zn, altered utilization of Cu- and Mn-dependent enzymes, mobilization of intracellular Fe stores, and increased production of the heme prosthetic group utilized by the enzyme target of fluconazole. Furthermore, RNA-seq analysis reveals that co-treatment with fluconazole and Cu gives rise to unique patterns of gene expression that illustrate the profound impacts of small fluctuations in Cu availability on the transcriptomic response to fluconazole stress. Finally, we show that fluconazole causes substantial changes to the metalloproteome of C. albicans, most notably to the levels of Cu proteins. The findings offer a new perspective for thinking about fungal response to drug stress that pushes cells out of their metal homeostatic zones, leading them to enact metal-associated adaptation mechanisms to restore homeostasis to survive. Advisors/Committee Members: Franz, Katherine J (advisor).
Subjects/Keywords: Chemistry; Inorganic chemistry; Microbiology; Candida albicans; Copper; Drug stress; Fungal infection; Metal homeostasis
Hunsaker, E. (2019). Insight into the Role of Metal Homeostasis in Fungal Adaptation to Drug Stress . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/20106
Hunsaker, Elizabeth. “Insight into the Role of Metal Homeostasis in Fungal Adaptation to Drug Stress .” 2019. Thesis, Duke University. Accessed January 21, 2021. http://hdl.handle.net/10161/20106.
Hunsaker, Elizabeth. “Insight into the Role of Metal Homeostasis in Fungal Adaptation to Drug Stress .” 2019. Web. 21 Jan 2021.
Hunsaker E. Insight into the Role of Metal Homeostasis in Fungal Adaptation to Drug Stress . [Internet] [Thesis]. Duke University; 2019. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/10161/20106.
Hunsaker E. Insight into the Role of Metal Homeostasis in Fungal Adaptation to Drug Stress . [Thesis]. Duke University; 2019. Available from: http://hdl.handle.net/10161/20106
15. Carballido Lopez, Ana Yaiza. Rôle des voies d'import du fer impliquant des sidérophores dans l'homéostasie de métaux biologiques autres que le fer chez Pseudomonas aeruginosa : Role of pyoverdine and pyochelin siderophores in the homeostasis of biological metals different than iron in Pseudomonas aeruginosa.
Degree: Docteur es, Aspects moléculaires et cellulaires de la biologie, 2018, Université de Strasbourg
URL: http://www.theses.fr/2018STRAJ008
Les métaux biologiques jouent un rôle clé en tant que cofacteurs, contribuant à la structuration des macromolécules et catalysant les réactions biochimiques dans les cellules.… (more)
Les métaux biologiques jouent un rôle clé en tant que cofacteurs, contribuant à la structuration des macromolécules et catalysant les réactions biochimiques dans les cellules. Ils sont nécessaires pour une croissance bactérienne optimale mais deviennent toxiques lorsqu'ils sont présents en excès. Par conséquent, l'homéostasie de ces métaux doit être finement régulée, et tout déséquilibre dans leur concentration pourrait affecter la viabilité cellulaire. Lors de cette thèse nous avons investigué les mécanismes moléculaires impliqués dans l'homéostasie du Fe chez Pseudomonas aeruginosa, en étudiant les deux principaux sidérophores produits par cette bactérie, pyoverdine (PVD) et pyochéline (PCH). Avec notre approche, nous avons identifié des nouveaux mécanismes de régulation des voies d’acquisition du fer par PVD et PCH. Nous avons également étudié comment d'autres métaux biologiques peuvent interférer avec ces voies, et le Co a montré une forte propension à pirater et à polluer la voie PCH.
Biological metals (Fe, Zn, Co, Ni, Mn, Cu) play a key role by acting as co-factors, contributing to macromolecule structuration, and catalyzing biochemical reactions into the cells. They are required for optimal bacterial growth but also become toxic when present in excess. Consequently, the homeostasis of these metals has to be finely regulated, and any disequilibrium in their concentration into bacteria could affect cell viability. We have further investigated the molecular mechanisms implicated in Fe homeostasis in Pseudomonas aeruginosa involving the two major siderophores produced by this bacterium, pyoverdine (PVD) and pyochelin (PCH). With our approach we identified new regulation mechanisms of both PVD and PCH pathways. In parallel, we have also investigated how other biological metals than Fe can interfere with these iron uptake pathways. Our data showed a strong propensity of Co to pirate and pollute the PCH iron uptake pathway.
Advisors/Committee Members: Schalk, Isabelle (thesis director).
Subjects/Keywords: Métal; Homéostasie; Cobalt; Fer; Pyochéline; Pyoverdine; P. aeruginosa; Régulation; Metal; Homeostasis; Cobalt; Iron; Pyochelin; Pyoverdine; P. aeruginosa; Regulation; 579.3; 572.4
Carballido Lopez, A. Y. (2018). Rôle des voies d'import du fer impliquant des sidérophores dans l'homéostasie de métaux biologiques autres que le fer chez Pseudomonas aeruginosa : Role of pyoverdine and pyochelin siderophores in the homeostasis of biological metals different than iron in Pseudomonas aeruginosa . (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2018STRAJ008
Carballido Lopez, Ana Yaiza. “Rôle des voies d'import du fer impliquant des sidérophores dans l'homéostasie de métaux biologiques autres que le fer chez Pseudomonas aeruginosa : Role of pyoverdine and pyochelin siderophores in the homeostasis of biological metals different than iron in Pseudomonas aeruginosa.” 2018. Doctoral Dissertation, Université de Strasbourg. Accessed January 21, 2021. http://www.theses.fr/2018STRAJ008.
Carballido Lopez, Ana Yaiza. “Rôle des voies d'import du fer impliquant des sidérophores dans l'homéostasie de métaux biologiques autres que le fer chez Pseudomonas aeruginosa : Role of pyoverdine and pyochelin siderophores in the homeostasis of biological metals different than iron in Pseudomonas aeruginosa.” 2018. Web. 21 Jan 2021.
Carballido Lopez AY. Rôle des voies d'import du fer impliquant des sidérophores dans l'homéostasie de métaux biologiques autres que le fer chez Pseudomonas aeruginosa : Role of pyoverdine and pyochelin siderophores in the homeostasis of biological metals different than iron in Pseudomonas aeruginosa. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2018. [cited 2021 Jan 21]. Available from: http://www.theses.fr/2018STRAJ008.
Carballido Lopez AY. Rôle des voies d'import du fer impliquant des sidérophores dans l'homéostasie de métaux biologiques autres que le fer chez Pseudomonas aeruginosa : Role of pyoverdine and pyochelin siderophores in the homeostasis of biological metals different than iron in Pseudomonas aeruginosa. [Doctoral Dissertation]. Université de Strasbourg; 2018. Available from: http://www.theses.fr/2018STRAJ008
16. Moldovan, Nataliya. MEASUREMENT OF TRANSITION METALS IN THE RODENT BRAIN USING X-RAY FLUORESCENCE AND NEUTRON ACTIVATION ANALYSIS.
Transition metals, such as iron, manganese, and copper are essential in the development and function of biological systems. However, disrupted levels of transition metals… (more)
Transition metals, such as iron, manganese, and copper are essential in the development and function of biological systems. However, disrupted levels of transition metals are highly cytotoxic, and metal homeostasis is strictly maintained in cells under normal conditions. The neuropathology of several brain disorders, such as Alzheimer’s disease and Parkinson’s disease has been linked to altered metal levels. This work focused on the measurement of iron, manganese, and copper, with the aim of better elucidating their role in brain disease. Two experiments were carried out in C57Bl/6 mice looking at metal homeostasis: 1. following manganese injections typically administered in manganese-enhanced MRI animal studies, and 2. following copper deficiency in a cuprizone model of demyelination. Metal measurements were made in the brain and visceral organs using X-ray fluorescence to measure iron and copper concentrations, and neutron activation analysis to measure manganese concentrations. In the MEMRI study in this work, in addition to the expected manganese concentration increases in brain regions, a statistically significant decrease in iron concentration in the thalamus was found. This change in iron levels in the thalamus following manganese injections should serve as a caution that care should be taken when interpreting signal changes in brain regions. The cuprizone study in this thesis confirmed that copper levels are reduced following cuprizone administration. Surprisingly, manganese concentrations were significantly higher in several brain regions that have demyelination in this model, but not iron or copper. The mechanism of cuprizone toxicity was related to manganese neurotoxicity that may contribute to demyelination.
Advisors/Committee Members: Bock, Nicholas, Farquharson, Michael, Valliant, John, Medical Physics.
Subjects/Keywords: transition metal homeostasis; cuprizone; manganese enhanced MRI; manganese overexposure; demyelination; x-ray fluorescence; neutron activation analysis; Medical Biophysics; Medical Biophysics
Moldovan, N. (2012). MEASUREMENT OF TRANSITION METALS IN THE RODENT BRAIN USING X-RAY FLUORESCENCE AND NEUTRON ACTIVATION ANALYSIS . (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/12372
Moldovan, Nataliya. “MEASUREMENT OF TRANSITION METALS IN THE RODENT BRAIN USING X-RAY FLUORESCENCE AND NEUTRON ACTIVATION ANALYSIS.” 2012. Masters Thesis, McMaster University. Accessed January 21, 2021. http://hdl.handle.net/11375/12372.
Moldovan, Nataliya. “MEASUREMENT OF TRANSITION METALS IN THE RODENT BRAIN USING X-RAY FLUORESCENCE AND NEUTRON ACTIVATION ANALYSIS.” 2012. Web. 21 Jan 2021.
Moldovan N. MEASUREMENT OF TRANSITION METALS IN THE RODENT BRAIN USING X-RAY FLUORESCENCE AND NEUTRON ACTIVATION ANALYSIS. [Internet] [Masters thesis]. McMaster University; 2012. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/11375/12372.
Moldovan N. MEASUREMENT OF TRANSITION METALS IN THE RODENT BRAIN USING X-RAY FLUORESCENCE AND NEUTRON ACTIVATION ANALYSIS. [Masters Thesis]. McMaster University; 2012. Available from: http://hdl.handle.net/11375/12372
17. Pinter, Tyler B. J. Reactions between Zinc Metallothionein and Carbonic Anhydrase.
Degree: 2015, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/3212
► More than 25% of proteins require metal ion cofactors for structure or function. The interactions between metalloproteins have largely been overlooked, though these interactions ultimately… (more)
▼ More than 25% of proteins require metal ion cofactors for structure or function. The interactions between metalloproteins have largely been overlooked, though these interactions ultimately govern metal localization and control metal ion homeostasis. Mammalian metallothionein (MT) is a small, cysteine-rich metalloprotein that binds numerous metal ions per protein strand. Up to seven divalent metals, such as zinc or cadmium, are wrapped into a clustered two-domain structure. This unusually high metal content places MT as an attractive candidate for studying interactions with other metal-binding proteins. This present study investigates the metal transfer reactions between MTs and other metalloproteins, using carbonic anhydrase (CA) as a putative zinc-dependent enzyme. This thesis presents electrospray ionization mass spectrometric (ESI-MS) data showing the competitive zinc metallation reactions between apoCA and various apoMTs. Modelling of the ESI-MS data is used to determine the reaction parameters and those parameters are shown to be reflected directly in the raw data. These results demonstrate how MT can act as a homeostatic buffer of metal ions, by binding them with different affinities. The kinetics of the metal transfers between zinc MTs and cadmium or zinc CA show that the rates of metal transfer between the two metalloproteins is directly dependent on the metal content of the MT. Further studies on the domain specific properties of MT using shortened MT domain fragment proteins show that: (i) there is no significant degree of domain specificity in metal binding to apoMTs; (ii) the weakest bound metal ion is located within the N-terminal domain of the intact MT protein; (iii) the highest affinity binding site is located within the C-terminal domain; and, (iv) domain-domain interactions within the MT peptide strand modulate metal binding affinities. Taken together, these results support the homeostatic roles of metallothionein proteins while also challenging the mechanisms for metal binding and release to apoenzymes.
Subjects/Keywords: Metal homeostasis; zinc; cadmium; metallothionein; carbonic anhydrase; electrospray ionization mass spectrometry; Analytical Chemistry; Biochemistry; Chemistry; Inorganic Chemistry
Pinter, T. B. J. (2015). Reactions between Zinc Metallothionein and Carbonic Anhydrase . (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3212
Pinter, Tyler B J. “Reactions between Zinc Metallothionein and Carbonic Anhydrase.” 2015. Thesis, University of Western Ontario. Accessed January 21, 2021. https://ir.lib.uwo.ca/etd/3212.
Pinter, Tyler B J. “Reactions between Zinc Metallothionein and Carbonic Anhydrase.” 2015. Web. 21 Jan 2021.
Pinter TBJ. Reactions between Zinc Metallothionein and Carbonic Anhydrase. [Internet] [Thesis]. University of Western Ontario; 2015. [cited 2021 Jan 21]. Available from: https://ir.lib.uwo.ca/etd/3212.
Pinter TBJ. Reactions between Zinc Metallothionein and Carbonic Anhydrase. [Thesis]. University of Western Ontario; 2015. Available from: https://ir.lib.uwo.ca/etd/3212
18. Kaluarachchi, Harini. SlyD, A Ni(II) Metallochaperone for [NiFe]-hydrogenase Biosynthesis in Escherichia coli.
SlyD is a protein involved in [NiFe]-hydrogenase enzyme maturation and, together with HypB and HypA proteins, contributes to the nickel delivery step. To understand the… (more)
SlyD is a protein involved in [NiFe]-hydrogenase enzyme maturation and, together with HypB and HypA proteins, contributes to the nickel delivery step. To understand the molecular details of this in vivo function, the nickel-binding activity of SlyD was investigated in vitro. SlyD is a monomeric protein that can chelate up to 7 nickel ions with an affinity in the sub-nanomolar range. By truncation and mutagenesis studies we show that the unique C-terminal metal-binding domain of this protein is required for Ni(II) binding and that the protein coordinates this metal non-cooperatively. This activity of SlyD supports the proposed in vivo role of SlyD in nickel homeostasis. In addition to nickel, SlyD can bind a variety of other types of transition metals. Therefore it was feasible that the protein contributes to homeostasis of metals other than nickel. To test this hypothesis, the metal selectivity of the protein was examined. The preference of SlyD for the metals examined could be ordered as follows, Mn(II), Fe(II) < Co(II) < Ni(II) ~ Zn(II) << Cu(I) indicating that the affinity of SlyD for the different metals follows the Irving-Williams series of metal-complex stabilities. Although the protein is unable to overcome the large thermodynamic preference in vitro for Cu(I) and exclude Zn(II) chelation, in vivo studies suggest a Ni(II)-specific function for the protein. To understand the function of SlyD as a metallochaperone, its interaction with HypB was investigated. This investigation revealed that SlyD plays a role in Ni(II) storage in E. coli and can function as a Ni(II)-donor to HypB. This study also revealed that SlyD can modulate the metal-binding as well as the GTPase activities of HypB. Based on the experimental data, a role for the HypB-SlyD complex in [NiFe]-hydrogenase biosynthesis is presented.
Advisors/Committee Members: Zamble, Deborah, Chemistry.
Subjects/Keywords: SlyD; Metal homeostasis; [NiFe]-hydrogenase; Metallochaperone; 0487
…transition metals was investigated in vitro and its role in metal homeostasis in vivo was examined… …binding to SlyD �� �� �� �� �� �� ��.. ��….. .......33 Figure 2-8 SlyD metal sites can compete with… …103 Figure 4-2 Metal transfer detection via ESI-MS �� �� �� �� �� �� �� �� �� ��. 113 Figure 4-3… …modulates the high-affinity metal site of HypB �� �� �� �� �� ��… ...116 Figure 4-6 Monitoring metal… …118 Figure 4-7 Metal release from HypB using different acceptors �� �� �� �� �� �� ��.. ...119…
Kaluarachchi, H. (2011). SlyD, A Ni(II) Metallochaperone for [NiFe]-hydrogenase Biosynthesis in Escherichia coli . (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/31797
Kaluarachchi, Harini. “SlyD, A Ni(II) Metallochaperone for [NiFe]-hydrogenase Biosynthesis in Escherichia coli.” 2011. Doctoral Dissertation, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/31797.
Kaluarachchi, Harini. “SlyD, A Ni(II) Metallochaperone for [NiFe]-hydrogenase Biosynthesis in Escherichia coli.” 2011. Web. 21 Jan 2021.
Kaluarachchi H. SlyD, A Ni(II) Metallochaperone for [NiFe]-hydrogenase Biosynthesis in Escherichia coli. [Internet] [Doctoral dissertation]. University of Toronto; 2011. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/31797.
Kaluarachchi H. SlyD, A Ni(II) Metallochaperone for [NiFe]-hydrogenase Biosynthesis in Escherichia coli. [Doctoral Dissertation]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/31797
19. Moulin, Pauline. Caractérisation du transporteur de zinc Adc/Lmb de Streptococcus agalactiae : Characterization of the ADC/LMB zinc transporter of Streptococcus agalactiae.
Degree: Docteur es, Sciences de la Vie et de la Santé, 2017, Université François-Rabelais de Tours
URL: http://www.theses.fr/2017TOUR3308
Dans cette étude, le transporteur ABC de zinc de Streptococcus agalactiae, première cause d’infections materno-foetale en France, a été caractérisé. Nous avons montré que ce… (more)
Dans cette étude, le transporteur ABC de zinc de Streptococcus agalactiae, première cause d’infections materno-foetale en France, a été caractérisé. Nous avons montré que ce transporteur se compose, du complexe perméase-ATPase AdcCB, associé à trois protéines membranaires Lmb, AdcA et AdcAII redondantes dans la fixation de zinc. Ce transporteur comporte également deux protéines Sht et ShtII, retrouvées au niveau de la paroi, et nécessaires aux protéines Lmb et AdcAII pour la capture de zinc. L’absence d’un transporteur fonctionnel, par la triple délétion des gènes lmb, adcA et adcAII ou du complexe adcCB, a révélé une inhibition de la croissance et une perturbation de la division de la bactérie lorsqu’elle se trouve dans un environnement carencé en zinc. De plus, nous avons montré que ce transporteur de zinc participe à la survie de la bactérie en milieux biologiques humains, comme le liquide amniotique ou le LCR, où la bactérie est retrouvée lors d’infections, suggérant l’importance du transporteur lors du processus infectieux. Ces résultats ont mis en évidence, pour la première fois, que le zinc assure des fonctions biologiques vitales pour S. agalactiae et que, dans des conditions de forte carence en zinc, le transporteur Adc/Lmb représente le principal système d’acquisition de zinc de la bactérie.
In this study, the zinc-ABC transporter of Streptococcus agalactiae, the first cause of materno-foetal infections in France, was characterized. We showed that this transporter is composed of an AdcCB permease-ATPase complex in association with three membrane-associated proteins Lmb, AdcA and AdcAII, which are redundant in zinc-binding. This transporter also possesses two proteins Sht and ShtII, which are associated to the cell wall, and that are necessary for the Lmb and AdcAII proteins for zinc capture. The absence of a functional transporter, by the triple deletion of the lmb, adcA and adcAII genes or the adcCB complex, revealed a growth inhibition and a disruption of the division of the bacterium when it is in a zinc-restricted environment. Furthermore, we showed that the zinc-ABC transporter contributes to the survival of the bacterium in human biological fluids, as the amniotic fluid or the cerebrospinal fluid, where the bacterium is found during infections, suggesting the importance of the transporter during the infectious process. These results hightlighted, for the first time, that zinc has biologically vital functions in S. agalactiae and that, under high zinc deficiency conditions, the Adc/Lmb transporter is the main zinc acquisition system of the bacterium.
Advisors/Committee Members: Mereghetti, Laurent (thesis director).
Subjects/Keywords: Streptococcus agalactiae; Transporteur ABC; Homéostasie du zinc; Protéine fixatrice de métaux; Streptococcus agalactiae; ABC transporter; Zinc homeostasis; Metal-binding protein
Moulin, P. (2017). Caractérisation du transporteur de zinc Adc/Lmb de Streptococcus agalactiae : Characterization of the ADC/LMB zinc transporter of Streptococcus agalactiae . (Doctoral Dissertation). Université François-Rabelais de Tours. Retrieved from http://www.theses.fr/2017TOUR3308
Moulin, Pauline. “Caractérisation du transporteur de zinc Adc/Lmb de Streptococcus agalactiae : Characterization of the ADC/LMB zinc transporter of Streptococcus agalactiae.” 2017. Doctoral Dissertation, Université François-Rabelais de Tours. Accessed January 21, 2021. http://www.theses.fr/2017TOUR3308.
Moulin, Pauline. “Caractérisation du transporteur de zinc Adc/Lmb de Streptococcus agalactiae : Characterization of the ADC/LMB zinc transporter of Streptococcus agalactiae.” 2017. Web. 21 Jan 2021.
Moulin P. Caractérisation du transporteur de zinc Adc/Lmb de Streptococcus agalactiae : Characterization of the ADC/LMB zinc transporter of Streptococcus agalactiae. [Internet] [Doctoral dissertation]. Université François-Rabelais de Tours; 2017. [cited 2021 Jan 21]. Available from: http://www.theses.fr/2017TOUR3308.
Moulin P. Caractérisation du transporteur de zinc Adc/Lmb de Streptococcus agalactiae : Characterization of the ADC/LMB zinc transporter of Streptococcus agalactiae. [Doctoral Dissertation]. Université François-Rabelais de Tours; 2017. Available from: http://www.theses.fr/2017TOUR3308
20. Hensley, Mart Patrick. Zinc Homeostasis in E. coli.
Degree: PhD, Chemistry, 2012, Miami University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=miami1333655875
► The homeostasis of transition metal ions is critical to the survival of all organisms. Zinc (Zn(II)) is one of the most important transition metals found… (more)
▼ The homeostasis of transition metal ions is critical to the survival of all organisms. Zinc (Zn(II)) is one of the most important transition metals found in biological systems; however, the homeostasis of this metal is poorly understood. Previous studies have shown that intracellular Zn(II) levels in E. coli are in the low millimolar range, yet there is less than one “free” (unbound) Zn(II) ion per cell. There must exist in the E. coli cell a mechanism for the delivery and insertion of Zn(II) into proteins. The cytoplasmic transport of other transitions metals, such as copper, iron, nickel, manganese, and arsenic, is accomplished by a group of proteins called metallochaperones. No such metallochaperone has been identified for Zn(II). Since none of the available models for intracellular Zn(II) transport are able to explain adequately Zn(II) homeostasis in E. coli, we hypothesized a new model. This model proposes that Zn(II) is delivered to Zn(II) metalloproteins as the proteins are translated and exiting the ribosome. In the co-translational model for Zn(II) homeostasis, the first datum that must be accounted for is the constant presence of 0.2 mM Zn(II) in E. coli. In Chapter 2 it is shown that the ribosome binds significant amounts of Zn(II). This ribosomal storage accounts for millimolar amounts of intracellular Zn(II). In Chapters 3 and 4 studies on several ribosomal proteins (L31, L13, L22, L24, and L29) are presented in an effort to identify Zn(II) binding proteins that could transfer Zn(II) to nascent proteins. Our data show that soluble L31 adopts a unique Zn(II) binding motif containing one cysteine and histidine. This Zn(II) binding site is reminiscent of the Cu(I) binding site of ATX1, a copper metallochaperone. Close examination of the E. coli ribosome crystal structures shows that L31 does not bind Zn(II) with the same binding site as in solution. By accounting for all known data about Zn(II) homeostasis in E. coli, it is hypothesized that ribosomal protein L31, while in solution and not bound to the ribosome, acts as a Zn(II) metallochaperone, delivering Zn(II) to nascent proteins as they exit the ribosome. Advisors/Committee Members: Crowder, Michael (Advisor), Makaroff, Christopher (Committee Chair).
Subjects/Keywords: Biochemistry; Zinc homeostasis; metal ion transport
…is not. Metal ion homeostasis has been most extensively studied in E. coli (12, 23… …of Zn(II) homeostasis is unprecedented in the literature for any metal ion… …and Helman, J., D. (2005) Metal ion homeostasis in Bacillus subtilis. Curr. Opin… …it is estimated that one out of every three proteins requires a metal cofactor (1)… …metal ions are essential for the viability of cells; however, these same metals are toxic if…
Hensley, M. P. (2012). Zinc Homeostasis in E. coli . (Doctoral Dissertation). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1333655875
Hensley, Mart Patrick. “Zinc Homeostasis in E. coli.” 2012. Doctoral Dissertation, Miami University. Accessed January 21, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1333655875.
Hensley, Mart Patrick. “Zinc Homeostasis in E. coli.” 2012. Web. 21 Jan 2021.
Hensley MP. Zinc Homeostasis in E. coli. [Internet] [Doctoral dissertation]. Miami University; 2012. [cited 2021 Jan 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1333655875.
Hensley MP. Zinc Homeostasis in E. coli. [Doctoral Dissertation]. Miami University; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1333655875
21. Sydor, Andrew. Metal Binding and Response of Helicobacter pylori HypB and Escherichia coli YjiA.
The biosynthesis of [NiFe]-hydrogenase and urease in Helicobacter pylori requires several accessory proteins for proper assembly of the nickel-containing active sites. Critical to the maturation… (more)
The biosynthesis of [NiFe]-hydrogenase and urease in Helicobacter pylori requires several accessory proteins for proper assembly of the nickel-containing active sites. Critical to the maturation of both enzymes in H. pylori is the GTPase HypB. In this work, the metal-binding properties of H. pylori HypB (HpHypB) were investigated and a link between metal binding and the other biochemical properties of HpHypB was established. HpHypB binds stoichiometric nickel or zinc with nanomolar affinities, in partially overlapping sites located between two major GTPase motifs. Upon metal binding, the GTP hydrolysis activity and oligomeric properties of the protein are modulated. Furthermore, the stoichiometry and affinity of the nickel is altered when HpHypB is bound to nucleotide, a change not observed for zinc. Mutagenesis of the metal ligands suggest that a conserved cysteine is responsible for transducing the metal-bound state to altered GTPase activity and a conserved histidine is a required nickel ligand only in the nucleotide-bound state. Together, these results suggest that the metal-binding and GTP hydrolysis properties of HpHypB are intimately linked and may comprise a mechanism through which the [NiFe]-hydrogenase and urease maturation pathways can discriminate between Ni(II) and Zn(II). Characterization of the Escherichia coli GTPase YjiA, a member of the same GTPase family as HpHypB, demonstrated that YjiA can bind Ni(II), Zn(II), or Co(II) at a site in a similar location as in HpHypB. Metal binding also regulates the GTPase activity and oligomerization of YjiA. This finding suggests that metal-responsive GTPase activity may be a trait of this family of GTPases. Together, this work describes a unique link between the metal-binding and biochemical properties of the G3E GTPases and provides insight into the role of HpHypB in [NiFe]-hydrogenase and urease maturation.
Subjects/Keywords: bioinorganic; nickel; nickel homeostasis; [NiFe]-hydrogeanse; GTPase; metal homeostasis; metal binding; 0487
…requirements and avoid toxic buildup of the metal, organisms have evolved complex nickel homeostasis… …Table 2-2 Stoichiometry of metal binding to WT and mutant HpHypB �� �� ��. 53 Table 2-3… …binding to WT, H107A, and C142S HpHypB ��…. 95 Table 3-8 Stoichiometry of metal binding to WT… …refinement statistics �� �� ��…. 134 Table 4-4 Stoichiometry of metal binding to WT and mutant YjiA… …nickel homeostasis �� �� �� �� �� �� �� �� �� �� 2 Figure 1-2 Structure of the Escherichia coli NikA…
Sydor, A. (2013). Metal Binding and Response of Helicobacter pylori HypB and Escherichia coli YjiA . (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/43738
Sydor, Andrew. “Metal Binding and Response of Helicobacter pylori HypB and Escherichia coli YjiA.” 2013. Doctoral Dissertation, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/43738.
Sydor, Andrew. “Metal Binding and Response of Helicobacter pylori HypB and Escherichia coli YjiA.” 2013. Web. 21 Jan 2021.
Sydor A. Metal Binding and Response of Helicobacter pylori HypB and Escherichia coli YjiA. [Internet] [Doctoral dissertation]. University of Toronto; 2013. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/43738.
Sydor A. Metal Binding and Response of Helicobacter pylori HypB and Escherichia coli YjiA. [Doctoral Dissertation]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/43738
Université de Grenoble
22. Trepreau, Juliette. Perception du stress métallique (nickel/cobalt) par le système de signalisation transmembranaire Cnr chez Cupriavidus metallidurans CH34 : Metal sensing (nickel/cobalt) by the transmembrane signalisation system Cnr of Cupriavidus metallidurans CH34.
Degree: Docteur es, Chimie biologie, 2011, Université de Grenoble
URL: http://www.theses.fr/2011GRENV061
CnrX est un senseur périplasmique, ancré à la membrane, appartenant au complexe CnrYXH qui contribue à réguler l'expression des gènes impliqués dans la résistance au… (more)
CnrX est un senseur périplasmique, ancré à la membrane, appartenant au complexe CnrYXH qui contribue à réguler l'expression des gènes impliqués dans la résistance au nickel et au cobalt chez Cupriavidus metallidurans CH34. La résistance est induite par la libération de CnrH, un facteur sigma de type ECF (Extracytoplasmic Function), par le complexe CnrYX en réponse à Ni et Co. Nous avons cherché à comprendre la manière dont CnrXs, le domaine senseur de CnrX, détecte les ions métalliques, les stratégies utilisées pour sélectionner spécifiquement Ni ou Co ainsi que la nature du signal engendré par cette interaction. Les techniques spectroscopiques et biophysiques telles que l'UV-visible, la RPE, le XAS et l'ITC ont permis d'étudier les sites métalliques en solution. Le dimère de CnrXs possède quatre sites de liaison au cobalt. Deux des sites (sites F) sont retrouvés dans la protéine entière dont nous avons maintenant un excellent modèle avec le mutant CnrXs-H32A. Les deux autres sites (sites E) ont un signal spectroscopique atypique probablement dû à la formation d'un complexe binucléaire de cobalt. Nous présentons également des structures à haute résolution de CnrXs dans ses formes apo et métallées par le nickel, cobalt ou zinc. Nous avons établi que la forme zinc est la forme inactive de la protéine et que le mécanisme de détection est engendrée par la substitution du zinc par le nickel et le cobalt dans le site F, conduisant à une modification majeure du site de liaison au métal. Tandis que le zinc est pentacoordiné dans une sphère 3N2O, Ni et Co recrutent le soufre de la seule méthionine (Met123) comme sixième ligand pour former un site octaédrique. Nous suggérons que Met123 soit l'interrupteur moléculaire dont la liaison avec le métal fait évoluer la structure de la protéine vers une conformation active. A notre connaissance, ces résultats constituent la première étude structurale et spectroscopique d'un senseur de métal périplasmique impliqué dans un système de transduction du signal dépendant d'un facteur sigma de type ECF.
CnrX is the membrane-anchored periplasmic sensor of the CnrYXH complex that contributes to regulate the expression of the genes involved in cobalt and nickel resistance in Cupriavidus metallidurans CH34. This resistance is induced by the release of the ExtraCytoplasmic Function (ECF) sigma factor CnrH from the CnrYX complex upon sensing of Ni or Co. We addressed the metal sensing mechanisms of CnrXs, the strategies used to select Ni or Co and the nature of the signal onset. Biophysical and spectroscopic techniques allowed us to study the metal binding sites in solution. The CnrXs dimer contains four cobalt binding sites. Two (F sites) are present in the full-length protein which H32A-CnrXs mutant is an excellent model of. The two other sites have an unusual spectroscopic signal that might be due to the formation of a binuclear cobalt complex. We present also high-resolution structures of CnrXs in the apo, Ni-, Co-, and Zn-bound forms. We propose that Zn-bound CnrX typifies the resting state…
Advisors/Committee Members: Covès, Jacques (thesis director), Maillard, Antoine (thesis director).
Subjects/Keywords: Transduction du signal; Homéostasie des métaux (nickel and cobalt; Facteur sigma ECF; Cupriavidus metallidurans CH34; Senseur de métaux; Résistance aux métaux; Signal transduction; Metal homeostasis (nickel/cobalt); ECF sigma factor; Cupriavidus metallidurans CH34; Metal sensor; Metal resistance; 570
Trepreau, J. (2011). Perception du stress métallique (nickel/cobalt) par le système de signalisation transmembranaire Cnr chez Cupriavidus metallidurans CH34 : Metal sensing (nickel/cobalt) by the transmembrane signalisation system Cnr of Cupriavidus metallidurans CH34 . (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2011GRENV061
Trepreau, Juliette. “Perception du stress métallique (nickel/cobalt) par le système de signalisation transmembranaire Cnr chez Cupriavidus metallidurans CH34 : Metal sensing (nickel/cobalt) by the transmembrane signalisation system Cnr of Cupriavidus metallidurans CH34.” 2011. Doctoral Dissertation, Université de Grenoble. Accessed January 21, 2021. http://www.theses.fr/2011GRENV061.
Trepreau, Juliette. “Perception du stress métallique (nickel/cobalt) par le système de signalisation transmembranaire Cnr chez Cupriavidus metallidurans CH34 : Metal sensing (nickel/cobalt) by the transmembrane signalisation system Cnr of Cupriavidus metallidurans CH34.” 2011. Web. 21 Jan 2021.
Trepreau J. Perception du stress métallique (nickel/cobalt) par le système de signalisation transmembranaire Cnr chez Cupriavidus metallidurans CH34 : Metal sensing (nickel/cobalt) by the transmembrane signalisation system Cnr of Cupriavidus metallidurans CH34. [Internet] [Doctoral dissertation]. Université de Grenoble; 2011. [cited 2021 Jan 21]. Available from: http://www.theses.fr/2011GRENV061.
Trepreau J. Perception du stress métallique (nickel/cobalt) par le système de signalisation transmembranaire Cnr chez Cupriavidus metallidurans CH34 : Metal sensing (nickel/cobalt) by the transmembrane signalisation system Cnr of Cupriavidus metallidurans CH34. [Doctoral Dissertation]. Université de Grenoble; 2011. Available from: http://www.theses.fr/2011GRENV061
23. Gault, Manon. L’homéostasie des métaux chez la bactérie Escherichia coli : de l’analyse générale d’un stress sur l’expression des gènes, à la compréhension des mécanismes moléculaires : Metal homeostasis in the bacterium E. coli : from the transcriptomic analysis of a stress, to the understanding of the molecular mechanisms.
Degree: Docteur es, Microbiologie, 2014, INSA Lyon
URL: http://www.theses.fr/2014ISAL0130
Les métaux sont indispensables à la vie cellulaire car ils sont constitutifs des protéines. Les ions Ni, font partie intégrante des hydrogénases, enzymes primordiales pour… (more)
Les métaux sont indispensables à la vie cellulaire car ils sont constitutifs des protéines. Les ions Ni, font partie intégrante des hydrogénases, enzymes primordiales pour le métabolisme énergétique. Paradoxalement, en excès, les métaux deviennent toxiques pour la cellule. Les bactéries luttent contre cette toxicité en produisant des systèmes de résistance ou d’adaptation. Les cellules procaryotes peuvent équilibrer les teneurs en métaux en contrôlant leur entrée ou leur efflux grâce à la biogenèse de transporteurs spécifiques. L’objectif de ces travaux de thèse a consisté à comprendre les mécanismes principaux permettant à la bactérie modèle Escherichia coli de s’adapter à de fortes variations en ions métalliques, en prenant comme modèle un stress provoqué par un excès d’ions Ni. Afin d’appréhender l’ensemble de la réponse cellulaire, l’effet de ce stress a été évalué sur l’expression de l’ensemble des gènes d’E. coli par des approches de transcriptomique couplées à une validation fonctionnelle. L’excès d’ions Ni induit le système d’efflux RcnRAB. En plus de la pompe d’efflux RcnA, ce système comporte une protéine périplasmique, RcnB, qui module le trafic des ions Ni ou Co via RcnA. Ces travaux ont montré que RcnB n’interagit pas avec les ions Ni ou Co mais de façon inattendue avec les ions Cu, définissant une nouvelle classe de cupro-protéines. Nous montrons que si RcnB n’intervient pas dans le contrôle de l’homéostasie du Cu, l’interaction avec ces ions est essentielle à sa fonction dans la modulation de l’efflux des ions Ni et Co. Ces résultats suggèrent des connexions entre les différents systèmes de maintien des homéostasies métalliques. Les résultats d’analyse transcriptomique montrent une forte modulation de l’expression des gènes impliqués dans les homéostasies du Cu et du Fe en présence d’un excès d’ions Ni, corrélée à une augmentation cellulaire de leur teneur mesurée par spectrométrie plasma. Ces métaux sont responsables de la production d’espèces réactives oxygénées entraînant de sérieux dégâts cellulaires, une des cibles privilégiée étant l’ADN. Nous montrons que les ions Ni ne provoquent pas de cassures de l’ADN et n’ont pas d’effet mutagène, par contre ils provoquent une modification importante de l’état de repliement de l’ADN. Nous proposons que ce relâchement de l’ADN soit dû à l’induction indirecte d’un stress oxydant. Ces travaux ont aboutis à l’identification du premier système de transport spécifique des ions Ni à travers la membrane externe chez E. coli. En résumé, un excès d’ions Ni affecte les systèmes spécifiques d’entrée et d’efflux des ions métalliques troublant les teneurs intracellulaires des autres métaux comme le Cu et le Fe. Ces métaux sont en partie responsables de la production de ROS létaux pour les cellules bactériennes. L’excès de Ni va induire une profonde reprogrammation génétique entraînant des changements physiologiques multifactoriels importants pour la survie bactérienne dans ces conditions de stress.
Metals are necessary components of all living cells because they are…
Advisors/Committee Members: Rodrigue, Agnès (thesis director).
Subjects/Keywords: Biosciences; Microbiologie; Escherichia coli; Métal; Homéostasie; Transcriptome; Mobilité cellulaire; Stress oxydant; Biosciences; Microbiology; Escherichia coli; Metal; Homeostasis; Transcriptome; Cellular mobility; Oxidative stress; DNA - Deoxyribonucleic acid; 579.307 2
Gault, M. (2014). L’homéostasie des métaux chez la bactérie Escherichia coli : de l’analyse générale d’un stress sur l’expression des gènes, à la compréhension des mécanismes moléculaires : Metal homeostasis in the bacterium E. coli : from the transcriptomic analysis of a stress, to the understanding of the molecular mechanisms . (Doctoral Dissertation). INSA Lyon. Retrieved from http://www.theses.fr/2014ISAL0130
Gault, Manon. “L’homéostasie des métaux chez la bactérie Escherichia coli : de l’analyse générale d’un stress sur l’expression des gènes, à la compréhension des mécanismes moléculaires : Metal homeostasis in the bacterium E. coli : from the transcriptomic analysis of a stress, to the understanding of the molecular mechanisms.” 2014. Doctoral Dissertation, INSA Lyon. Accessed January 21, 2021. http://www.theses.fr/2014ISAL0130.
Gault, Manon. “L’homéostasie des métaux chez la bactérie Escherichia coli : de l’analyse générale d’un stress sur l’expression des gènes, à la compréhension des mécanismes moléculaires : Metal homeostasis in the bacterium E. coli : from the transcriptomic analysis of a stress, to the understanding of the molecular mechanisms.” 2014. Web. 21 Jan 2021.
Gault M. L’homéostasie des métaux chez la bactérie Escherichia coli : de l’analyse générale d’un stress sur l’expression des gènes, à la compréhension des mécanismes moléculaires : Metal homeostasis in the bacterium E. coli : from the transcriptomic analysis of a stress, to the understanding of the molecular mechanisms. [Internet] [Doctoral dissertation]. INSA Lyon; 2014. [cited 2021 Jan 21]. Available from: http://www.theses.fr/2014ISAL0130.
Gault M. L’homéostasie des métaux chez la bactérie Escherichia coli : de l’analyse générale d’un stress sur l’expression des gènes, à la compréhension des mécanismes moléculaires : Metal homeostasis in the bacterium E. coli : from the transcriptomic analysis of a stress, to the understanding of the molecular mechanisms. [Doctoral Dissertation]. INSA Lyon; 2014. Available from: http://www.theses.fr/2014ISAL0130
24. Grillo, Anthony Steven. Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies.
Degree: PhD, Chemistry, 2017, University of Illinois – Urbana-Champaign
► Traditional approaches in the pharmaceutical industry center around the development of small molecule therapeutics that bind to and inhibit overactive protein function. This has been… (more)
▼ Traditional approaches in the pharmaceutical industry center around the development of small molecule therapeutics that bind to and inhibit overactive protein function. This has been transformational in the treatment of diseases resulting from an excess of protein function, however, thousands of diseases are alternatively caused by a deficiency of protein function and thus remain incurable. A major subset of these are characterized by mutations in critical ion channels and transporters, such as microcytic anemias, cystic fibrosis, and cardiovascular diseases. Deficiencies of these ion transporting proteins diminish ion flux in distinct sites and directions. Noting the many features that make small molecules advantageous as drugs, we asked can small molecules that imperfectly replicate the function of these missing proteins be sufficient to restore physiology in protein-deficient organisms. Since the networks of active and passive ion transporting proteins remain active, we hypothesized an imperfect small molecule ion transporter could restore site- and direction-selective transport by leveraging ion gradients that selectively buildup in ion-transport protein deficiencies, thereby restoring physiology to the protein deficient organism. Iron is a critical cofactor in all forms of life, yet its excess is paradoxically toxic. Organisms have thus developed sophisticated homeostatic networks of iron-transport proteins and their regulators to maintain iron at levels sufficient for normal iron-dependent physiological processes without causing ferritoxicity. Acquired or congenital deficiencies of proteins involved in iron transport, homeostasis, or metabolism often impede the movement of iron into, within, and/or out of cells and are associated with more than 25 Mendelian diseases. We therefore asked whether a small molecule iron transporter could leverage transmembrane gradients of the labile iron pool that selectively build up in such situations to restore the movement of iron into, within, and/or out of cells and thereby enable its use in endogenous iron-dependent physiological processes. We first used iron-deficient yeast as a discovery platform to find a small molecule candidate. In a modified functional complementation assay, the small molecule natural product, hinokitiol, restored growth to yeast missing the iron transporting complex Fet3Ftr1. Hinokitiol promoted iron uptake, and concomitantly restored cell growth back to wild-type levels. In contrast to water soluble iron chelators, hinokitiol:iron complexes are lipid soluble, and readily diffuse through lipid membranes. Extensive biophysical studies suggest this growth restoration can be attributed to the capacity for hinokitiol to promote the transmembrane transport of iron. Encouraged by these results, we next tested the capacity for hinokitiol to promote gut iron absorption and/or hemoglobinization in cells and animals missing three different iron-transport proteins by promoting iron mobilization and utilization. Hinokitiol restored the uptake and… Advisors/Committee Members: Burke, Martin D (advisor), Burke, Martin D (Committee Chair), Denmark, Scott E (committee member), Mitchell, Douglas A (committee member), Zimmerman, Steven C (committee member).
Subjects/Keywords: Hinokitiol; Iron transport; Divalent metal transporter 1 (DMT1); Ferroportin-1 (FPN1); Mitoferrin 1 (MFRN1); Small molecule iron transporter; Iron transporter; Molecular prosthetic; Molecular prosthetics; Iron biology; Hemoglobinization; Iron homeostasis
Grillo, A. S. (2017). Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies . (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/99210
Grillo, Anthony Steven. “Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies.” 2017. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 21, 2021. http://hdl.handle.net/2142/99210.
Grillo, Anthony Steven. “Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies.” 2017. Web. 21 Jan 2021.
Grillo AS. Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2017. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2142/99210.
Grillo AS. Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2017. Available from: http://hdl.handle.net/2142/99210
25. Toukoki, Chadia. MTSR is a Dual Regulator that Controls Virulence Genes and Metabolic Functions in Addition to Metal Homeostasis in Group A Streptococcus.
Degree: PhD, Biology, 2009, Georgia State University
URL: https://scholarworks.gsu.edu/biology_diss/66
► Group A Streptococcus (GAS) is a common pathogen of the human skin and mucosal surfaces and is capable of producing a variety of diseases. This… (more)
▼ Group A Streptococcus (GAS) is a common pathogen of the human skin and mucosal surfaces and is capable of producing a variety of diseases. This dissertation investigates the function of a metalloregulator named MtsR in GAS physiology and disease process. An mtsR mutant was constructed and analyzed. Consistent with MtsR role in iron uptake regulation, the mtsR mutant accumulates more iron (80 ± 22.5%) than the wild type strain. Inactivation of mtsR results in constitutive transcription of the sia (Streptococcal Iron Acquisition) operon, which is negatively regulated by iron in the parent strain. We identified the promoter that controls the expression of the sia operon (Pshr) and used it as a model to study MtsR interaction with DNA. Electrophoretic mobility gel shift assays (EMSAs) demonstrated that MtsR binds to the shr upstream region specifically and in an iron and manganese dependent manner. DNase I footprint analysis revealed that MtsR protects a 69 bp segment in Pshr that includes 2 inverted repeats, overlapping the core promoter elements. A global transcriptional analysis determined that MtsR modulates the expression of 64 genes, of which 44 were upregulated and 20 were downregulated in the mtsR mutant. MtsR controls genes with diverse functions including immune evasion, colonization, dissemination, metal homeostasis, nucleic acid and amino acid metabolism, and protein stability. MtsR functions as a dual regulator as it binds to the promoters of the repressed genes ska, aroE, and nrdF.2, as well as the upstream region of the positively regulated genes mga, emm49, and pyrF. A 16 bp MtsR-binding consensus region was identified in all of the promoters that are directly regulated by MtsR. In conclusion, we have demonstrated that MtsR is a global regulator in GAS that controls the expression of vital virulence factors and genes involved in metal transport, virulence and metabolic pathways. Advisors/Committee Members: Zehava Eichenbaum - Chair, John Houghton, Chung-Dar Lu, Phang C. Tai.
Subjects/Keywords: Iron regulation; Sia operon; Metal homeostasis; Virulence; Microarray; Streptococcus pyogenes; Biology
Toukoki, C. (2009). MTSR is a Dual Regulator that Controls Virulence Genes and Metabolic Functions in Addition to Metal Homeostasis in Group A Streptococcus . (Doctoral Dissertation). Georgia State University. Retrieved from https://scholarworks.gsu.edu/biology_diss/66
Toukoki, Chadia. “MTSR is a Dual Regulator that Controls Virulence Genes and Metabolic Functions in Addition to Metal Homeostasis in Group A Streptococcus.” 2009. Doctoral Dissertation, Georgia State University. Accessed January 21, 2021. https://scholarworks.gsu.edu/biology_diss/66.
Toukoki, Chadia. “MTSR is a Dual Regulator that Controls Virulence Genes and Metabolic Functions in Addition to Metal Homeostasis in Group A Streptococcus.” 2009. Web. 21 Jan 2021.
Toukoki C. MTSR is a Dual Regulator that Controls Virulence Genes and Metabolic Functions in Addition to Metal Homeostasis in Group A Streptococcus. [Internet] [Doctoral dissertation]. Georgia State University; 2009. [cited 2021 Jan 21]. Available from: https://scholarworks.gsu.edu/biology_diss/66.
Toukoki C. MTSR is a Dual Regulator that Controls Virulence Genes and Metabolic Functions in Addition to Metal Homeostasis in Group A Streptococcus. [Doctoral Dissertation]. Georgia State University; 2009. Available from: https://scholarworks.gsu.edu/biology_diss/66
26. Sigdel, Tara. A Search for Zn(II) Metallochaperones in E. coli, Proteomic and Genomic Approaches.
► Zinc is a transition metal that exists exclusively in the +2 oxidation state in biological systems (Zn(II)). Zn(II) serves as a catalytic cofactor in members… (more)
▼ Zinc is a transition metal that exists exclusively in the +2 oxidation state in biological systems (Zn(II)). Zn(II) serves as a catalytic cofactor in members from all classes of enzymes and as a structural component in dozens of proteins. Despite being essential for the structural/catalytic properties of many cellular proteins, excess Zn(II) is toxic to cells. Recent reports demonstrate that E. coli cells contain low millimolar concentrations of Zn(II); however, subsequent studies reveal that there are no pools of free Zn(II) in the cytoplasm of the cell. Several groups have hypothesized the existence of Zn(II)-metallochaperones, which bind and deliver Zn(II) ions; however, no such proteins have yet been identified. This dissertation describes our efforts to identify the Zn(II)-responsive proteins in E. coli by using proteomics (2D gels coupled with peptide identification) and genomics (cDNA microarrays). Proteomic studies identified a number of proteins with differential expression levels in response to extracellular Zn(II) levels; however, none of the identified proteins have previously been associated with Zn(II) transport. cDNA microarrays identified a number of differentially-expressed transcripts in response to stress by Zn(II) excess and deficiency, and several of the corresponding proteins were hypothesized to be Zn(II)-metallochaperones. One candidate protein, YodA, was cloned, over-expressed, and used as bait in a pulldown assay. Comparisons of results from the proteomic and genomic approaches demonstrate a surprising lack of consistency, which indicates that caution should be used when applying these techniques to study global protein/RNA changes in response to external stimuli. In summary, this dissertation describes an approach to probe for the Zn(II) metallome of an organism, and this approach can be extended to other organisms to better understand the homeostatic pathways used to maintain intracellular metal ion concentrations. Advisors/Committee Members: Crowder, Michael (Advisor).
Subjects/Keywords: E. Coli; Zinc transport and homeostasis; Proteomics; cDNA microarray; 2D gel; metal transport
Sigdel, T. (2005). A Search for Zn(II) Metallochaperones in E. coli, Proteomic and Genomic Approaches . (Doctoral Dissertation). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1128394584
Sigdel, Tara. “A Search for Zn(II) Metallochaperones in E. coli, Proteomic and Genomic Approaches.” 2005. Doctoral Dissertation, Miami University. Accessed January 21, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1128394584.
Sigdel, Tara. “A Search for Zn(II) Metallochaperones in E. coli, Proteomic and Genomic Approaches.” 2005. Web. 21 Jan 2021.
Sigdel T. A Search for Zn(II) Metallochaperones in E. coli, Proteomic and Genomic Approaches. [Internet] [Doctoral dissertation]. Miami University; 2005. [cited 2021 Jan 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1128394584.
Sigdel T. A Search for Zn(II) Metallochaperones in E. coli, Proteomic and Genomic Approaches. [Doctoral Dissertation]. Miami University; 2005. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1128394584
27. Nery, Camille Reyes. Novel Repression Mechanisms for Metal Transport Genes in Saccharomyces cerevisiae.
Degree: Biochemistry & Molecular Biology, 2013, UCLA
URL: http://www.escholarship.org/uc/item/34r7x122
► The transition metals iron and zinc are essential requirements for all living organisms. They participate in a variety of critical metabolic pathways, enzymatic activity, and… (more)
▼ The transition metals iron and zinc are essential requirements for all living organisms. They participate in a variety of critical metabolic pathways, enzymatic activity, and provide structural support for countless proteins. Metal ion imbalance can be detrimental to organisms, as metal deficiency can alter many biological processes while metal excess can lead to toxicity. To alleviate these detrimental situations, the yeast Saccharomyces cerevisiae has developed tightly controlled regulatory mechanisms for the proper expression of proteins that control import, export, and storage of these essential metals. This regulation is required to ensure the efficient uptake, transport, and storage of specific metal ions during periods of metal concentration fluctuations. The work presented in the first chapter of this dissertation identifies the use of cryptic transcription as a means for regulatory control of the subtelomeric metal genes ZRT1 and FIT3. These transcripts arise from promoter units upstream of the ZRT1/FIT3 transcription unit and extend into the open reading frame (ORF). We show that these transcripts are degraded by the cytoplasmic Non-Sense Mediated Decay (NMD) Pathway and are only stabilized in the absence of the NMD Pathway; hence termed Cytoplasmically Degraded Cryptic Unstable Transcripts (CD-CUTs). We further show that these CD-CUTs act to prevent expression of ZRT1 by interfering with RNA polymerase II binding and activator binding (Zap1p) to the ZRT1 promoter unit. As we identified the use of CD-CUTs to mediate the repression of ZRT1/FIT3 during normal zinc/iron conditions, the mechanistic mode of action of these transcripts remained elusive. In an attempt to identify how a cytoplasmically degraded transcript can mediate transcription in the nucleus, we chose to study the cytoplasmic trafficking of these species. In chapter two, we show that the export of the ZRT1/FIT3 CD-CUTs is likely mediated by the SR-type mRNA export factor Hrb1p and dependent on the essential mRNA export factor Mex67p. Lastly, we identify an additional mode of regulation for the iron transport gene FIT3 by the glucose repressor Mig1p. Mig1p has been extensively characterized as a repressor of glucose responsive genes and in chapter three, we show that this regulation can be applied to iron regulation. We believe that Mig1p regulates the repression of FIT3 during conditions of normal iron and/or after switch back to normal iron conditions following iron starvation to prevent the deleterious expression of FIT3, thereby preventing the potentially harmful effects of iron toxicity.
Subjects/Keywords: Biochemistry; Molecular biology; Cryptic Transcription; FIT3; Glucose repressor; Metal Homeostasis; Metal Transport Genes; mRNA export
…of Metal Homeostasis Genes (PloS Genetics, 2011). Many thanks to PloS Genetics… …Mediates Repression of Subtelomeric Metal Homeostasis Genes, PLoS Genetics 7(6)… …Cryptic Transcription Mediates Transcription of Metal Homeostasis Genes 1… …intergenic regions lie upstream of many subtelomeric genes involved in metal homeostasis; namely… …used as a mechanism for regulatory control of genes involved in metal homeostasis and not…
Nery, C. R. (2013). Novel Repression Mechanisms for Metal Transport Genes in Saccharomyces cerevisiae . (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/34r7x122
Nery, Camille Reyes. “Novel Repression Mechanisms for Metal Transport Genes in Saccharomyces cerevisiae.” 2013. Thesis, UCLA. Accessed January 21, 2021. http://www.escholarship.org/uc/item/34r7x122.
Nery, Camille Reyes. “Novel Repression Mechanisms for Metal Transport Genes in Saccharomyces cerevisiae.” 2013. Web. 21 Jan 2021.
Nery CR. Novel Repression Mechanisms for Metal Transport Genes in Saccharomyces cerevisiae. [Internet] [Thesis]. UCLA; 2013. [cited 2021 Jan 21]. Available from: http://www.escholarship.org/uc/item/34r7x122.
Nery CR. Novel Repression Mechanisms for Metal Transport Genes in Saccharomyces cerevisiae. [Thesis]. UCLA; 2013. Available from: http://www.escholarship.org/uc/item/34r7x122
28. Passalacqua, Karla Diane. Characterization of the superoxide dismutases of Bacillus anthracis: Global and local approaches to the study of bacterial oxidative stress and metal ion homeostasis.
Degree: PhD, Microbiology, 2007, University of Michigan
► Bacillus anthracis, the causative agent of the disease anthrax, is a gram-positive bacterium found in soil habitats worldwide and exists in two morphologies: infectious, inert… (more)
▼ Bacillus anthracis, the causative agent of the disease anthrax, is a gram-positive bacterium found in soil habitats worldwide and exists in two morphologies: infectious, inert spores and replicative vegetative bacilli. We hypothesize that protective antioxidant enzymes and metal uptake systems contribute to bacterial fitness during the establishment of disease. We undertook in vitro physiological studies of B. anthracis on both global and local scales to define the roles that superoxide dismutases (SODs) play in this microbe's biology and to better characterize the connection between bacterial oxidative stress and metal ion homeostasis. The creation of multiple sod deletion (Deltasod ) mutants showed that of the four putative B. anthracis sods, sodA1 encodes the predominantly active enzyme responsible for protection from oxidative insults. The SODA1 and SODA2 paralogs form active homodimers and heterodimers, but only slight physiological redundancy exists between the two. A third paralog, SOD15, is differentially expressed upon entry into stationary/sporulation phase, and is a member of a four-gene operon that may be involved in bacterial morphology. However, the SODs are not essential for survival within a mouse model of inhalational anthrax. The global transcriptional profiles of B. anthracis to physiological redox perturbations imposed by hydrogen peroxide and paraquat showed that whereas hydrogen peroxide results in a response mainly defined by DNA metabolism, endogenous superoxide elicits a response indicative of metal ion homeostasis imbalances. B. anthracis produces two iron-chelating siderophores: petrobactin and bacillibactin. We found that transcriptional control of the genes needed for synthesis of these two metabolites is unique, and that end-point metabolite yields vary depending on metal availability and oxygenation. Lastly, we found that manganese availability protects B. anthracis from oxidative damage to proteins, and that mutants lacking both sodA1 and sodA2 are sensitive to manganese and iron limitation, connecting antioxidant capability, metal homeostasis, and metabolic efficiency. These in vitro observations shed light on the multiple physiological capabilities of B. anthracis and reveal the many ways that this microorganism is able to efficiently establish disease. Advisors/Committee Members: Hanna, Philip C. (advisor).
Subjects/Keywords: Anthrax; Approaches; Bacillus Anthracis; Bacterial; Characterization; Global; Local; Metal Ion Homeostasis; Microarrays; Oxidative Stress; Siderophores; Study; Superoxide Dismutases
Passalacqua, K. D. (2007). Characterization of the superoxide dismutases of Bacillus anthracis: Global and local approaches to the study of bacterial oxidative stress and metal ion homeostasis. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/126958
Passalacqua, Karla Diane. “Characterization of the superoxide dismutases of Bacillus anthracis: Global and local approaches to the study of bacterial oxidative stress and metal ion homeostasis.” 2007. Doctoral Dissertation, University of Michigan. Accessed January 21, 2021. http://hdl.handle.net/2027.42/126958.
Passalacqua, Karla Diane. “Characterization of the superoxide dismutases of Bacillus anthracis: Global and local approaches to the study of bacterial oxidative stress and metal ion homeostasis.” 2007. Web. 21 Jan 2021.
Passalacqua KD. Characterization of the superoxide dismutases of Bacillus anthracis: Global and local approaches to the study of bacterial oxidative stress and metal ion homeostasis. [Internet] [Doctoral dissertation]. University of Michigan; 2007. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2027.42/126958.
Passalacqua KD. Characterization of the superoxide dismutases of Bacillus anthracis: Global and local approaches to the study of bacterial oxidative stress and metal ion homeostasis. [Doctoral Dissertation]. University of Michigan; 2007. Available from: http://hdl.handle.net/2027.42/126958
29. LeVora, Jennifer K. THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS.
Degree: 2012, IUPUI
URL: http://hdl.handle.net/1805/3177
Indiana University-Purdue University Indianapolis (IUPUI)
The etiology of many neurodegenerative diseases is unknown, but a number of studies indicate that a combination of both genetic… (more)
The etiology of many neurodegenerative diseases is unknown, but a number of studies indicate that a combination of both genetic and environmental factors contribute to the progression of disease. Exposure to environmental metals, such as Mn2+, Fe2+, Cu2+, and Al3+, has been shown to increase cell death that is characteristic of neurodegenerative disorders such as AD, PD, Wilson’s disease and Menkes disease. These metals are important in numerous biological processes in the brain and their homeostasis is regulated through multiple mechanisms of transport, storage, and secretion. The vertebrate divalent metal transporter-1 (DMT-1) has been implicated in transport and homeostasis of these divalent cations. In these studies I utilize Caenorhabditis elegans (C. elegans) to show that long term exposure to Mn2+ decreases animal viability in a dose-dependent manner, and I demonstrate that C. elegans homologues to DMT-1, SMF-1, SMF-2, and SMF-3, play specific roles in divalent metal ion-induced DA neurodegeneration. I show that SMF-1 contributes to Fe2+-induced DA neuron degeneration, SMF-3 contributes to Al3+-induced DA neuron degeneration, and both SMF-2 and DAT-1 contribute to Cu2+-induced DA neuron cell death. These studies utilize C. elegans as a powerful model to characterize molecules and pathways involved in metal toxicity and metal-induced DA neuron degeneration.
Advisors/Committee Members: Nass, Richard M., Nicol, Grant D., Hingtgen, Cynthia M., 1966-.
Subjects/Keywords: dopamine; C. elegans; SMF; aluminum; copper; Parkinson's Disease; Dopamine; Neurotoxicology; Cell death; Parkinson's disease; Metal ions – Physiological effect; Nervous system – Degeneration – Molecular aspects; Oxidative stress; Metals – Toxicology; Homeostasis; Caenorhabditis elegans; Mitochondrial pathology; Copper – Physiological effect; Hepatolenticular degeneration; Alzheimer's disease
LeVora, J. K. (2012). THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS . (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/3177
LeVora, Jennifer K. “THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS.” 2012. Thesis, IUPUI. Accessed January 21, 2021. http://hdl.handle.net/1805/3177.
LeVora, Jennifer K. “THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS.” 2012. Web. 21 Jan 2021.
LeVora JK. THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS. [Internet] [Thesis]. IUPUI; 2012. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1805/3177.
LeVora JK. THE ROLE OF SMF 1, SMF-2, SMF-3 IN METAL-INDUCED WHOLE ANIMAL VULNERABILITY AND DOPAMINE NEURON DEGENERATION IN CAENORHABDITIS ELEGANS. [Thesis]. IUPUI; 2012. Available from: http://hdl.handle.net/1805/3177
30. Haas, Kathryn Louise. Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition .
► Mechanisms of copper homeostasis are of great interest partly due to their connection to debilitating genetic and neurological disorders. The family of high-affinity copper… (more)
▼ Mechanisms of copper homeostasis are of great interest partly due to their connection to debilitating genetic and neurological disorders. The family of high-affinity copper transporters (Ctr) is responsible for extracellular copper acquisition and internalization in yeast, plants, and mammals, including human. The extracellular domain of the human high-affinity copper transporter (hCtr1) contains essential Cu-binding methionine-rich MXXM and MXM (Mets) motifs that are important for copper acquisition and transport. The hCtr1 extracellular domain also contains potential copper binding histidine (His) clusters, including a high-affinity Cu(II) ATCUN site. As of yet, extracellular His clusters have no established significance for hCtr1 function. We have made model peptides based on the extracellular copper acquisition domain of hCtr1 that is rich in His residues and Mets motifs. The peptides' Cu(I) and Cu(II) binding properties have been characterized by UV-Vis and mass spectrometry. Our findings have been extended to a mouse cell model and we show that His residues are important for hCtr1 function likely because of their contribution to strong copper-binding sites in the hCtr1 extracellular domain responsible for copper acquisition. Copper's pro-oxidant property is also medicinally promising if it can be harnessed to induce oxidative stress as a cancer chemotherapy strategy. Our lab has designed a photocleavable caged copper complex that can selectively release redox-active copper in response to light. The thermodynamic copper binding properties of these potential chemotherapeutics have been characterized Advisors/Committee Members: Franz, Katherine J (advisor).
Subjects/Keywords: Chemistry, Inorganic; Chemistry, Biochemistry; Caged Copper; Copper; Copper Transport; Ctr1; Membrane Protein; Metal Homeostasis
Haas, K. L. (2010). Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/2373
Haas, Kathryn Louise. “Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition .” 2010. Thesis, Duke University. Accessed January 21, 2021. http://hdl.handle.net/10161/2373.
Haas, Kathryn Louise. “Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition .” 2010. Web. 21 Jan 2021.
Haas KL. Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition . [Internet] [Thesis]. Duke University; 2010. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/10161/2373.
Haas KL. Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition . [Thesis]. Duke University; 2010. Available from: http://hdl.handle.net/10161/2373
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1. Valm, Alex Mihkel. Combinatorial Labeling and Spectral Imaging (CLASI): A novel microscopy method for the systems-level analysis of biological structure and its application to the study of human oral microbial community organization.
Degree: PhD, Pathobiology, 2012, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:297560/
► Just as the phenotypically different cells that make up multicellular organisms are distributed in tissues with structures that embody specific functions, microbial cells with different… (more)
▼ Just as the phenotypically different cells that make up multicellular organisms are distributed in tissues with structures that embody specific functions, microbial cells with different metabolic functions form unique spatial structures and coordinate their activities as multicellular units, e.g. biofilms. Fundamentally, microbial communities differ from eukaryotic tissues because their cellular constituents may be genetically distinct; in fact, up to hundreds of different species may be present in a single biofilm. Any number of probes may be designed to identify the different species present in a community; however, the ability to unambiguously distinguish more than a few different labels in a single fluorescence image has been severely hampered by the excitation cross talk and signal bleed-through of fluorophores with highly overlapping emission spectra. Reported in this thesis is a fluorescence labeling, imaging, and analysis method to greatly expand the number of identifiable labels in a single image, which we call Combinatorial Labeling and Spectral Imaging (CLASI). Application of our CLASI technique to human dental plaque using fluorescence in situ hybridization (FISH) enabled the first quantitative analysis of the spatial distribution of 15 different taxa of microbes in a biofilm. Proximity analysis was used to determine the frequency of inter- and intrataxon cell-to-cell associations, which revealed statistically significant intertaxon pairings. Cells of the genera Prevotella and Actinomyces showed the most interspecies associations, suggesting a central role for these genera in establishing and maintaining biofilm complexity. In a proof-of-principle experiment, we further demonstrate that we can distinguish 120 differently labeled E. coli in a mixture labeled with binary combinations of 16 fluorophores using a novel linear unmixing algorithm constrained to identify specific combinations of fluorophores. Our results provide an initial systems-level structural analysis of biofilm organization and we further believe that the CLASI approach will be useful for the architectural analysis of many complex molecular structures within cells. Advisors/Committee Members: Oldenbourg, Rudolf (Director), Borisy, Gary (Director), Atwood, Walter (Reader), Reichner, Jonathan (Reader), Danuser, Gaudenz (Reader).
Subjects/Keywords: fluorescence imaging
Valm, A. M. (2012). Combinatorial Labeling and Spectral Imaging (CLASI): A novel microscopy method for the systems-level analysis of biological structure and its application to the study of human oral microbial community organization . (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:297560/
Valm, Alex Mihkel. “Combinatorial Labeling and Spectral Imaging (CLASI): A novel microscopy method for the systems-level analysis of biological structure and its application to the study of human oral microbial community organization.” 2012. Doctoral Dissertation, Brown University. Accessed January 21, 2021. https://repository.library.brown.edu/studio/item/bdr:297560/.
Valm, Alex Mihkel. “Combinatorial Labeling and Spectral Imaging (CLASI): A novel microscopy method for the systems-level analysis of biological structure and its application to the study of human oral microbial community organization.” 2012. Web. 21 Jan 2021.
Valm AM. Combinatorial Labeling and Spectral Imaging (CLASI): A novel microscopy method for the systems-level analysis of biological structure and its application to the study of human oral microbial community organization. [Internet] [Doctoral dissertation]. Brown University; 2012. [cited 2021 Jan 21]. Available from: https://repository.library.brown.edu/studio/item/bdr:297560/.
Valm AM. Combinatorial Labeling and Spectral Imaging (CLASI): A novel microscopy method for the systems-level analysis of biological structure and its application to the study of human oral microbial community organization. [Doctoral Dissertation]. Brown University; 2012. Available from: https://repository.library.brown.edu/studio/item/bdr:297560/
2. Chen, Yu-wei. Sliced fluorescence imaging: a versatile method to study photo-induced dynamic processes.
Degree: PhD, Chemistry, 2009, NSYSU
► To reduce the image blurring which originates from contributions of a cylindrical array of photolysis events in a photo-induced experiment, a variant of fluorescence imaging… (more)
▼ To reduce the image blurring which originates from contributions of a cylindrical array of photolysis events in a photo-induced experiment, a variant of fluorescence imaging techniques has been developed to study photodissociation dynamics and collisional relaxation processes in the bulk. The experimental arrangement utilizes sliced imaging techniques of photofragments by the laser-induced fluorescence detection scheme. An unconventional procedure is employed to guide the photolysis laser in the viewing direction of the imaging detector with a proper obstruction. The sliced image in the direction perpendicular to the photolysis laser is equivalent to a two-dimensional projection of the fluorescence image of photoproducts from a single photolysis center. Experimental images of state-selected CN photofragments from the ICN photodissociation are presented to illustrate the versatility of the present method. Advisors/Committee Members: Shang-wu Ding (chair), Kuo-mei Chen (committee member), Kopin Liu (chair), Chao-ming Chiang (chair), King-chuen Lin (chair).
Subjects/Keywords: Sliced fluorescence imaging
Chen, Y. (2009). Sliced fluorescence imaging: a versatile method to study photo-induced dynamic processes . (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0908109-155557
Chen, Yu-wei. “Sliced fluorescence imaging: a versatile method to study photo-induced dynamic processes.” 2009. Doctoral Dissertation, NSYSU. Accessed January 21, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0908109-155557.
Chen, Yu-wei. “Sliced fluorescence imaging: a versatile method to study photo-induced dynamic processes.” 2009. Web. 21 Jan 2021.
Chen Y. Sliced fluorescence imaging: a versatile method to study photo-induced dynamic processes. [Internet] [Doctoral dissertation]. NSYSU; 2009. [cited 2021 Jan 21]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0908109-155557.
Chen Y. Sliced fluorescence imaging: a versatile method to study photo-induced dynamic processes. [Doctoral Dissertation]. NSYSU; 2009. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0908109-155557
3. Srikun, Duangkhae. New Chemical Tools for Fluorescent Detection of Hydrogen Peroxide in Living Cells.
Degree: Chemistry, 2011, University of California – Berkeley
URL: http://www.escholarship.org/uc/item/4cj4q4xv
► As one of the toxic by-product of aerobic metabolism, hydrogen peroxide (H2O2), at uncontrolled levels and distributions, is a sign of oxidative stress, aging and… (more)
▼ As one of the toxic by-product of aerobic metabolism, hydrogen peroxide (H2O2), at uncontrolled levels and distributions, is a sign of oxidative stress, aging and disease. However, H2O2 also plays an essential part in normal physiological system. H2O2 levels are regulated by many enzymes and metabolites that generate or break-down H2O2. In macrophages, the presence of invading pathogens activates the production of microbicidal levels of H2O2 by NADPH oxidase (Nox). Isoforms of Nox are expressed in many non-phagocytic cells and tissues. Nox-generated H2O2 is a secondary messenger involved in signaling for growth, proliferation, differentiation and controlled cell death; these variations in downstream biological effects are regulated by both the spatial and temporal production of H2O2. Small molecule fluorescent probes bearing boronate ester moieties have been developed for chemoselective detection of H2O2 in both oxidative stress levels and cellular signaling events. This dissertation describes the design, synthesis, characterization and application of new boronate-based fluorescent probes with added functionality. Peroxy-Lucifer-1 (PL1) and Peroxy-Naphthalene-1 (PN1) are ratiometric fluorescent probes that can detect oxidative bursts in immune response events. Ratiometric probes allow simultaneous detection of two signals from the reacted and unreacted probes in the same sample, providing a built-in correction for variations such as uneven probe loading, sample environment and detection efficiency. PN1 also has a high two-photon cross section. The increased penetration depth of near-infrared excitation light allows the detection of H2O2 in tissue specimens with PN1. SNAP-Peroxy-Green-1 (SPG1) and SNAP-Peroxy-Green-2 (SPG2) are capable of detecting local concentration of H2O2 in subcellular compartments such as mitochondria, endoplasmic reticulum, nucleus, and plasma membrane. The precise localization of probes to the targeted organelle is facilitated by highly specific recognition of the SNAP ligand bound to the probe by the SNAP fusion protein. Furthermore, simultaneous detection of H2O2 at two different locations is feasible by using a SNAP tag with an orthogonal CLIP tag; such combined use of SNAP and CLIP tags is assisted by the expanding color palette of SNAP and CLIP peroxy probes. Multi-modal probes using PAMAM-G5 dendrimer platform was developed for the real-time imaging of the interplay between H2O2 and other physiological events. Coordination of the oxidative burst and progressive acidification in phagosomes of macrophages was elucidated with G5-SNARF2-PF1-Ac, a nanoprobe decorated with the H2O2 sensing module PF1 and pH sensor SNARF2.
Subjects/Keywords: Chemistry; Fluorescence Imaging; Hydrogen Peroxide
Srikun, D. (2011). New Chemical Tools for Fluorescent Detection of Hydrogen Peroxide in Living Cells . (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/4cj4q4xv
Srikun, Duangkhae. “New Chemical Tools for Fluorescent Detection of Hydrogen Peroxide in Living Cells.” 2011. Thesis, University of California – Berkeley. Accessed January 21, 2021. http://www.escholarship.org/uc/item/4cj4q4xv.
Srikun, Duangkhae. “New Chemical Tools for Fluorescent Detection of Hydrogen Peroxide in Living Cells.” 2011. Web. 21 Jan 2021.
Srikun D. New Chemical Tools for Fluorescent Detection of Hydrogen Peroxide in Living Cells. [Internet] [Thesis]. University of California – Berkeley; 2011. [cited 2021 Jan 21]. Available from: http://www.escholarship.org/uc/item/4cj4q4xv.
Srikun D. New Chemical Tools for Fluorescent Detection of Hydrogen Peroxide in Living Cells. [Thesis]. University of California – Berkeley; 2011. Available from: http://www.escholarship.org/uc/item/4cj4q4xv
4. Cooper, Justin T. Single-molecule fluorescence microscopy of molecular interactions at reversed-phase chromatographic interfaces.
Degree: PhD, Chemistry, 2014, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3354/rec/2197
► The development of techniques to probe molecular transport and the dynamics of molecular interactions at interfaces is important for understanding and optimizingsurface-based technologies including surface-enhanced… (more)
▼ The development of techniques to probe molecular transport and the dynamics of molecular interactions at interfaces is important for understanding and optimizingsurface-based technologies including surface-enhanced spectroscopies, biological assays, sensors, catalysis, and chemical separations. In particular, the efficiency and resolution of separation via reversed-phase liquid chromatography is governed by the interaction ofanalytes with the solution/stationary phase interface. Most commonly, the stationary phase material consists of high surface area, micron-sized, mesoporous silica particles functionalized with n-alkane ligands. Understanding the timescales at which analytemolecules are transported through the interior of the particle, as well as adsorbed and desorbed from the particle surface, is of fundamental importance in the development of new, more efficient chromatographic materials.Probing chemical interactions at interfaces is difficult due to the selectivity needed to measure the small population of molecules at an interface versus bulk solution. Measuring interfacial chemical interactions within chromatographic particles has the added challenge that the majority of the surface area is contained within the particle making it difficult to measure interfacial processes directly.In this work, single-molecule spectroscopic techniques are used to measure the transport and adsorption/desorption kinetics of molecules at planar reversed-phase chromatographic interfaces and within reversed-phase chromatographic particles. Fluorescence imaging with single-molecule tracking is used to track the locations of fluorescent molecules during their retention within chromatographic particles. Thisyields information regarding their diffusion rates and their residence time within the particle. Statistical criteria based on the single-molecule localization resolution are also developed to characterize the population of strongly adsorbed molecules and their effect on intraparticle molecular residence times. Fluorescence imaging is also combined with fluorescence-correlation spectroscopy and used to measure fast interfacial transport and sorption kinetics at planar models of chromatographic interfaces. This technique has higher temporal resolutionrelative to imaging and is capable of measuring transport approaching free solution diffusion rates of small molecules.Finally, a comparison is made between interfacial transport rates and surface populations measured at planar chromatographic interfacial models versus within porous particles. It is found that n-alkyl modified planar interfaces are reasonable models for reversed-phase chromatographic particles with proper interpretation of measured parameters.
Subjects/Keywords: Fluorescence; Microscopy; Single-molecule imaging
Cooper, J. T. (2014). Single-molecule fluorescence microscopy of molecular interactions at reversed-phase chromatographic interfaces . (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3354/rec/2197
Cooper, Justin T. “Single-molecule fluorescence microscopy of molecular interactions at reversed-phase chromatographic interfaces.” 2014. Doctoral Dissertation, University of Utah. Accessed January 21, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3354/rec/2197.
Cooper, Justin T. “Single-molecule fluorescence microscopy of molecular interactions at reversed-phase chromatographic interfaces.” 2014. Web. 21 Jan 2021.
Cooper JT. Single-molecule fluorescence microscopy of molecular interactions at reversed-phase chromatographic interfaces. [Internet] [Doctoral dissertation]. University of Utah; 2014. [cited 2021 Jan 21]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3354/rec/2197.
Cooper JT. Single-molecule fluorescence microscopy of molecular interactions at reversed-phase chromatographic interfaces. [Doctoral Dissertation]. University of Utah; 2014. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3354/rec/2197
5. Quang, Timothy. Development and Evaluation of a Multi-Modal Optical Imaging System for Early Identification of Oral Neoplasia.
► Over the last decade, the five-year survival rate for oral cancer has remained at only 64%. Despite easy access to the oral cavity, most patients… (more)
▼ Over the last decade, the five-year survival rate for oral cancer has remained at only 64%. Despite easy access to the oral cavity, most patients with oral cancer are diagnosed at an advanced stage when treatment is more invasive and likely to be less successful. Imaging tools that can rapidly and accurately identify oral neoplasia could improve early detection of malignant oral lesions. This dissertation describes research to develop and evaluate a multi-modal optical imaging system with automated image processing to improve early detection of oral neoplasia. The multi-modal optical imaging system is comprised of two modalities, a high-resolution microendoscope (HRME) and a wide-field autofluorescence imager (AFI) to identify suspicious areas and to confirm whether suspicious areas contain neoplasia. A tablet-interfaced HRME with automated image analysis was developed and characterized to improve early detection of esophageal squamous cell carcinoma which has similar histologic patterns to oral neoplasia; results showed the tablet HRME can acquire comparable images to the first generation HRME design at a fraction of the cost and size. Training and validation was performed using a previously published dataset from a study of 177 patients referred for screening or surveillance endoscopy in China. Results showed that the automated image processing could differentiate between neoplastic and non-neoplastic images with a sensitivity of 95% and 91% in an independent validation set compared with 84% and 95% achieved in the original study. Additionally, automated image processing tools were developed to analyze wide-field autofluorescence images. The diagnostic performance of this approach was compared to previous results from a pilot study of 30 patients scheduled for surgical resection of a clinically suspicious oral lesion. The automated analysis method achieved a comparable area under the receiver operating characteristic curve (AUC) to the previous results based on manual analysis (0.862 automated vs. 0.877 manual) while minimizing dependence on user input. The automated analysis algorithms for AFI and HRME were then evaluated together to analyze images acquired from a population of 100 patients scheduled for surgical resection of a clinically suspicious oral lesion. A classification algorithm based on image metrics derived from AFI and HRME was able to correctly classify 100% of sites taken from biopsies pathologically diagnosed as normal and 85% of sites taken from biopsies diagnosed as moderate/severe dysplasia or cancer. These results provide evidence that multi-modal optical imaging with automated image analysis could be a valuable diagnostic adjunct for early detection of oral neoplasia. Advisors/Committee Members: Richards-Kortum, Rebecca (advisor).
Subjects/Keywords: optical imaging; oral cancer; fluorescence
Quang, T. (2016). Development and Evaluation of a Multi-Modal Optical Imaging System for Early Identification of Oral Neoplasia . (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/95635
Quang, Timothy. “Development and Evaluation of a Multi-Modal Optical Imaging System for Early Identification of Oral Neoplasia.” 2016. Doctoral Dissertation, Rice University. Accessed January 21, 2021. http://hdl.handle.net/1911/95635.
Quang, Timothy. “Development and Evaluation of a Multi-Modal Optical Imaging System for Early Identification of Oral Neoplasia.” 2016. Web. 21 Jan 2021.
Quang T. Development and Evaluation of a Multi-Modal Optical Imaging System for Early Identification of Oral Neoplasia. [Internet] [Doctoral dissertation]. Rice University; 2016. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1911/95635.
Quang T. Development and Evaluation of a Multi-Modal Optical Imaging System for Early Identification of Oral Neoplasia. [Doctoral Dissertation]. Rice University; 2016. Available from: http://hdl.handle.net/1911/95635
6. Sims, Ruth Rebecca. Volumetric Imaging Across Spatiotemporal Scales in Biology with Fluorescence Microscopy.
Degree: PhD, 2019, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/289719
► Quantitative three dimensional maps of cellular structure, activity and function provide the key to answering many prevalent questions in modern biological research. Fluorescence microscopy has… (more)
▼ Quantitative three dimensional maps of cellular structure, activity and function provide the key to answering many prevalent questions in modern biological research. Fluorescence microscopy has emerged as an indispensable tool in generating such maps, but common techniques are limited by fundamental physical constraints which render them incapable of simultaneously achieving high spatial and temporal resolution. This thesis will describe the development of novel microscopy techniques and complementary computational tools capable of addressing some of the aforementioned limitations of fluorescence microscopy and further outline their application in providing novel biological insights. The first section details the design of a light sheet microscope capable of high-throughput imaging of cleared, macroscopic samples with cellular resolution. In light sheet microscopy, the combination of spatially confined illumination with widefield detection enables multi-megapixel acquisition in a single camera exposure. The corresponding increase in acquisition speed enables systems level biological studies to be performed. The ability of this microscope to perform rapid, high-resolution imaging of intact samples is demonstrated by its application in a project which established a niche and hierarchy for stem cells in the adult nervous system. Light sheet microscopy achieves fast volumetric imaging rates, but the two dimensional nature of each measurement results in an inevitable lag between acquisition of the initial and final planes. The second section of this thesis describes the development and optimization of a light field microscope which captures volumetric information in a snapshot. Light field microscopy is a computational technique and images are reconstructed from raw data. Both the fidelity of computed volumes and the efficiency of the algorithms are strongly dependent on the quality of the rectification. A highly accurate, automated procedure is presented in this section. Light field reconstruction techniques are investigated and compared and the results are used to inform the re-design of the microscope. The new optical configuration is demonstrated to minimize the long-object problem. In the final section of the thesis, the spatial resolution limits of light field microscopy are explored using a combination of simulations and experiments. It is shown that light field microscopy is capable of localizing point sources over a large depth of field with high axial and lateral precision. Notably, this work paves the way towards frame rate limited super resolution localization microscopy with a depth of field larger than the thickness of a typical mammalian cell.
Subjects/Keywords: Fluorescence microscopy; Computational imaging; Volumetric imaging
Sims, R. R. (2019). Volumetric Imaging Across Spatiotemporal Scales in Biology with Fluorescence Microscopy . (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/289719
Sims, Ruth Rebecca. “Volumetric Imaging Across Spatiotemporal Scales in Biology with Fluorescence Microscopy.” 2019. Doctoral Dissertation, University of Cambridge. Accessed January 21, 2021. https://www.repository.cam.ac.uk/handle/1810/289719.
Sims, Ruth Rebecca. “Volumetric Imaging Across Spatiotemporal Scales in Biology with Fluorescence Microscopy.” 2019. Web. 21 Jan 2021.
Sims RR. Volumetric Imaging Across Spatiotemporal Scales in Biology with Fluorescence Microscopy. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Jan 21]. Available from: https://www.repository.cam.ac.uk/handle/1810/289719.
Sims RR. Volumetric Imaging Across Spatiotemporal Scales in Biology with Fluorescence Microscopy. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/289719
7. Goolsby, Demesheka. Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes.
Degree: MS, Chemistry, 2016, Georgia State University
URL: https://scholarworks.gsu.edu/chemistry_theses/91
► Calcium (Ca2+), a crucial effector for many biological systems, has been associated with diseases such as cardiovascular disease, Alzheimer’s, Parkinson’s, cancer, and osteoporosis. It… (more)
▼ Calcium (Ca2+), a crucial effector for many biological systems, has been associated with diseases such as cardiovascular disease, Alzheimer’s, Parkinson’s, cancer, and osteoporosis. It is important to develop calcium sensors to measure intracellular Ca2+ dynamics at various biological and pathological states. Our lab has engineered such probes by designing a Ca2+ binding site into fluorescent proteins such as Enhanced Green Fluorescent Protein (EGFP) and mCherry. In this thesis, we aim to improve optical properties and metal binding properties of green EGFP-based sensor CatchER and mCherry based red sensors by site-directed mutagenesis and protein engineering, various spectroscopic methods and cell imaging. The green EGFP-based sensor CatchER, with a Ca2+ binding pocket charge of -5, displays the greatest affinity for Ca2+ and has the greatest fluorescence intensity change with Ca2+ when compared to its variants with a less negative binding pocket charge. In addition, we have also designed several SR/ER targeting CatchER variants using Ryanodine receptor and Calnexin transmembrane domains. These constructs were shown to display a strong presence in the SR/ER lumen and further designed for a new luminal orientation. Further, we have shown that the optical properties of two red calcium sensors can be significantly improved by modifying the local environment of the chromophore. Advisors/Committee Members: Jenny Yang, Dabney Dixon, Donald Hamelberg.
Subjects/Keywords: Fluorescence; mCherry; EGFP; Calcium imaging; Fluorescence spectroscopy; Fluorescence lifetime
Goolsby, D. (2016). Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes . (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/chemistry_theses/91
Goolsby, Demesheka. “Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes.” 2016. Thesis, Georgia State University. Accessed January 21, 2021. https://scholarworks.gsu.edu/chemistry_theses/91.
Goolsby, Demesheka. “Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes.” 2016. Web. 21 Jan 2021.
Goolsby D. Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes. [Internet] [Thesis]. Georgia State University; 2016. [cited 2021 Jan 21]. Available from: https://scholarworks.gsu.edu/chemistry_theses/91.
Goolsby D. Optical Property Enhancement And Characterization Of Fluorescent Protein Based Intracellular Calcium Probes. [Thesis]. Georgia State University; 2016. Available from: https://scholarworks.gsu.edu/chemistry_theses/91
8. Garrison, Zachary "Zach" Ryan. Modification of Nanohoop Fluorophores to Improve Use in Biological Imaging.
Degree: 2020, University of Oregon
URL: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25748
► Biological imaging is an extremely important tool for biological and medical research. It allows researchers and doctors to access a perspective of biological systems not… (more)
▼ Biological imaging is an extremely important tool for biological and medical research. It allows researchers and doctors to access a perspective of biological systems not available with the naked eye. However, the quality of the images and the subsequent discoveries that come from those images depends on the quality of the reporter molecule (i.e fluorophore) used. As such, there is a wide variety of commercially available fluorophores that emit light all along the visible spectrum. Unfortunately, many of these commercially available fluorophores suffer from limitations that restrict their imaging applications. This would make the introduction of a new fluorophore that overcomes these limitations a valuable discovery. One molecular structure that does not suffer from those same limitations is a cycloparaphenylene (CPP), which is a symmetrical arrangement of phenyl rings linked at the para-position. These nanohoop structures have unique size dependent fluorescent properties and can be controllably synthesized to possess characteristics desired for a variety of applications. This project was able to make further modifications to the nanohoop structure that unlocked new colors and worked towards improving the conjugation of the molecules to biological entities.
Subjects/Keywords: Biochemistry; Chemistry; Organic Chemistry; Fluorescence Imaging; Flourophores; Imaging; Nanohoops; Cycloparaphenylene; Fluorescence
Garrison, Z. ". R. (2020). Modification of Nanohoop Fluorophores to Improve Use in Biological Imaging . (Thesis). University of Oregon. Retrieved from https://scholarsbank.uoregon.edu/xmlui/handle/1794/25748
Garrison, Zachary "Zach" Ryan. “Modification of Nanohoop Fluorophores to Improve Use in Biological Imaging.” 2020. Thesis, University of Oregon. Accessed January 21, 2021. https://scholarsbank.uoregon.edu/xmlui/handle/1794/25748.
Garrison, Zachary "Zach" Ryan. “Modification of Nanohoop Fluorophores to Improve Use in Biological Imaging.” 2020. Web. 21 Jan 2021.
Garrison Z"R. Modification of Nanohoop Fluorophores to Improve Use in Biological Imaging. [Internet] [Thesis]. University of Oregon; 2020. [cited 2021 Jan 21]. Available from: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25748.
Garrison Z"R. Modification of Nanohoop Fluorophores to Improve Use in Biological Imaging. [Thesis]. University of Oregon; 2020. Available from: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25748
9. Ayyalasomayajula, Kalyan Ram. Development and Validation of Analytical Models for Diffuse Fluorescence Spectroscopy/Imaging in Regular Geometries.
Degree: MSc Engg, Faculty of Engineering, 2018, Indian Institute of Science
► New advances in computational modeling and instrumentation in the past decade has enabled the use of electromagnetic radiation for non-invasive monitoring of the physio-logical state… (more)
▼ New advances in computational modeling and instrumentation in the past decade has enabled the use of electromagnetic radiation for non-invasive monitoring of the physio-logical state of biological tissues. The near infrared (NIR) light having the wavelength range of 600 nm -1000 nm has been the main contender in these emerging molecular imaging modalities. Assessment of accurate pathological condition of the tissue under investigation relies on the contrast in the molecular images, where the endogenous contrast may not be sufficient in these scenarios. The fluorescence (exogenous) contrast agents have been deployed to overcome these difficulties, where the preferential uptake by the tumor vasculature leads to high contrast,making this modality one of the biggest contenders in small-animal and soft-tissue molecular imaging modalities. In Fluorescence diffuse optical spectroscopy/imaging, this exogenous drug is excited by NIR laser light causing the emission of the fluorescence light. The emitted fluorescence light is typically dependent on the life time and concentration of the exogenous drug coupled with physiology associated with the tissue under investigation. As there is an excitation and emission of the light,the underlying physics of the problem is described by a coupled diffusion equations. These coupled diffusion equations are typically solved by advanced numerical methods, which tend to be computationally demanding. In this work, analytical solutions for these coupled partial differential equations (PDEs) for the regular geometries for both time-domain and frequency-domain cases were developed. Till now, the existing literature has not dealt with all regular geometries and derived analytical solutions were only for couple of geometries. Here a universally acceptable generic solution was developed based on Green’s function approach that is applicable to any regular geometry. Using this, the analytical solutions for the regular geometries that is encountered in diffuse fluorescence spectroscopy/imaging were obtained. These solutions can play an important role in determining the bulk fluorescence properties of the tissue, which could act as good initial guesses for the advanced image reconstruction techniques and/or can also facilitate the calibration of experimental fluorescence data by removing biases and source-detector variations. In the second part of this work, the developed analytical models for regular geometries were validated through comparison with the established numerical models that are traditionally used in the diffuse fluorescence spectroscopy/imaging. This comparison not only validated the developed analytical models, but also showed that analytical models are capable of providing bulk fluorescence properties with at least one order of magnitude less computational cost compared to the highly optimized traditional numerical models. Advisors/Committee Members: Yalavarthy, Phaneendra K (advisor).
Subjects/Keywords: Medical Optics; Medical Imaging; Diffuse Fluorescence Spectroscopy; Fluorescence Diffuse Optical Imaging; Fluorescence Diffuse Optical Spectroscopy; Diffuse Fluorescence Spectroscopy/Imaging; Fluorescence Spectroscopy/Imaging - Mathematical Models; Molecular Imaging; Fouorescence Spectroscopy/Imaging; Fluorescence Optical Breast Imaging; Flrorescence Optical Brain Imaging; Fluorescence Diffuse Optical Imaging; FDOI; Biotechnology
Ayyalasomayajula, K. R. (2018). Development and Validation of Analytical Models for Diffuse Fluorescence Spectroscopy/Imaging in Regular Geometries . (Masters Thesis). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/3275
Ayyalasomayajula, Kalyan Ram. “Development and Validation of Analytical Models for Diffuse Fluorescence Spectroscopy/Imaging in Regular Geometries.” 2018. Masters Thesis, Indian Institute of Science. Accessed January 21, 2021. http://etd.iisc.ac.in/handle/2005/3275.
Ayyalasomayajula, Kalyan Ram. “Development and Validation of Analytical Models for Diffuse Fluorescence Spectroscopy/Imaging in Regular Geometries.” 2018. Web. 21 Jan 2021.
Ayyalasomayajula KR. Development and Validation of Analytical Models for Diffuse Fluorescence Spectroscopy/Imaging in Regular Geometries. [Internet] [Masters thesis]. Indian Institute of Science; 2018. [cited 2021 Jan 21]. Available from: http://etd.iisc.ac.in/handle/2005/3275.
Ayyalasomayajula KR. Development and Validation of Analytical Models for Diffuse Fluorescence Spectroscopy/Imaging in Regular Geometries. [Masters Thesis]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/3275
University of Texas – Austin
10. -4953-3644. Optical and structural property mapping of soft tissues using spatial frequency domain imaging.
Degree: PhD, Biomedical engineering, 2015, University of Texas – Austin
► Tissue optical properties, absorption, scattering and fluorescence, reveal important information about health, and holds the potential for non-invasive diagnosis and therefore earlier treatment for many… (more)
▼ Tissue optical properties, absorption, scattering and fluorescence, reveal important information about health, and holds the potential for non-invasive diagnosis and therefore earlier treatment for many diseases. On the other hand, tissue structure determines its function. Studying tissue structural properties helps us better understand structure-function relationship. Optical imaging is an ideal tool to study these tissue properties. However, conventional optical imaging techniques have limitations, such as not being able to quantitatively evaluate tissue absorption and scattering properties and only providing volumetrically averaged quantities with no depth control capability. To better study tissue properties, we integrated spatial frequency domain imaging (SFDI) with conventional reflectance imaging modalities. SFDI is a non-invasive, non-contact wide-field imaging technique which utilizes structured illumination to probe tissues. SFDI imaging is able to accurately quantify tissue optical properties. By adjusting spatial frequency, the imaging depth can be tuned which allows for depth controlled imaging. Especially at high spatial frequency, SFDI reflectance image is more sensitive to tissue scattering property than absorption property. The imaging capability of SFDI allows for studying tissue properties from a whole new perspective. In our study, we developed both benchtop and handheld SFDI imaging systems to accommodate different applications. By evaluating tissue optical properties, we corrected attenuation in fluorescence imaging using an analytical model; and we quantified optical and physical properties of skin diseases. By imaging at high spatial frequency, we demonstrated that absorption in fluorescence imaging can also be reduced because of a reduced imaging depth. This correction can be performed in real-time at 19 frames/second. Furthermore, fibrous structures orientation from the superficial layer can be accurately quantified in a multi-layered sample by limiting imaging depth. Finally, we color rendered SFDI reflectance image at high spatial frequency to reveal structural changes in skin lesions. Advisors/Committee Members: Tunnell, James W. (advisor), Krishnan, Sunil (committee member), Reichenberg, Jason S (committee member), Yeh, Hsin-Chih (committee member), Sacks, Michael (committee member).
Subjects/Keywords: Spatial frequency domain imaging; Fluorescence imaging; Polarized light imaging; Hyperspectral imaging; Imaging instrument
-4953-3644. (2015). Optical and structural property mapping of soft tissues using spatial frequency domain imaging . (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/31345
-4953-3644. “Optical and structural property mapping of soft tissues using spatial frequency domain imaging.” 2015. Doctoral Dissertation, University of Texas – Austin. Accessed January 21, 2021. http://hdl.handle.net/2152/31345.
-4953-3644. “Optical and structural property mapping of soft tissues using spatial frequency domain imaging.” 2015. Web. 21 Jan 2021.
-4953-3644. Optical and structural property mapping of soft tissues using spatial frequency domain imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2015. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2152/31345.
-4953-3644. Optical and structural property mapping of soft tissues using spatial frequency domain imaging. [Doctoral Dissertation]. University of Texas – Austin; 2015. Available from: http://hdl.handle.net/2152/31345
11. Gao, Shengkui. Bio-Inspired Multi-Spectral Imaging Sensors and Algorithms for Image Guided Surgery.
Degree: PhD, Computer Science & Engineering, 2015, Washington University in St. Louis
URL: https://openscholarship.wustl.edu/eng_etds/118
► Image guided surgery (IGS) utilizes emerging imaging technologies to provide additional structural and functional information to the physician in clinical settings. This additional visual… (more)
▼ Image guided surgery (IGS) utilizes emerging imaging technologies to provide additional structural and functional information to the physician in clinical settings. This additional visual information can help physicians delineate cancerous tissue during resection as well as avoid damage to near-by healthy tissue. Near-infrared (NIR) fluorescence imaging (700 nm to 900 nm wavelengths) is a promising imaging modality for IGS, namely for the following reasons: First, tissue absorption and scattering in the NIR window is very low, which allows for deeper imaging and localization of tumor tissue in the range of several millimeters to a centimeter depending on the tissue surrounding the tumor. Second, spontaneous tissue fluorescence emission is minimal in the NIR region, allowing for high signal-to-background ratio imaging compared to visible spectrum fluorescence imaging. Third, decoupling the fluorescence signal from the visible spectrum allows for optimization of NIR fluorescence while attaining high quality color images. Fourth, there are two FDA approved fluorescent dyes in the NIR region—namely methylene blue (MB) and indocyanine green—which can help to identify tumor tissue due to passive accumulation in human subjects. The aforementioned advantages have led to the development of NIR fluorescence imaging systems for a variety of clinical applications, such as sentinel lymph node imaging, angiography, and tumor margin assessment. With these technological advances, secondary surgeries due to positive tumor margins or damage to healthy organs can be largely mitigated, reducing the emotional and financial toll on the patient. Currently, several NIR fluorescence imaging systems (NFIS) are available commercially or are undergoing clinical trials, such as FLARE, SPY, PDE, Fluobeam, and others. These systems capture multi-spectral images using complex optical equipment and are combined with real-time image processing to present an augmented view to the surgeon. The information is presented on a standard monitor above the operating bed, which requires the physician to stop the surgical procedure and look up at the monitor. The break in the surgical flow sometimes outweighs the benefits of fluorescence based IGS, especially in time-critical surgical situations. Furthermore, these instruments tend to be very bulky and have a large foot print, which significantly complicates their adoption in an already crowded operating room. In this document, I present the development of a compact and wearable goggle system capable of real-time sensing of both NIR fluorescence and color information. The imaging system is inspired by the ommatidia of the monarch butterfly, in which pixelated spectral filters are integrated with light sensitive elements. The pixelated spectral filters are fabricated via a carefully optimized nanofabrication procedure and integrated with a CMOS imaging array. The entire imaging system has been optimized for high signal-to-background fluorescence imaging using an analytical approach, and… Advisors/Committee Members: Viktor Gruev, Mark Anastasio, Roger Chamberlain, Yasutaka Furukawa, Richard Loomis, Robert Pless.
Subjects/Keywords: Imaging Sensor; Imaging System; Multi-spectral Imaging; NIR fluorescence; Polarization; Engineering
Gao, S. (2015). Bio-Inspired Multi-Spectral Imaging Sensors and Algorithms for Image Guided Surgery . (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/118
Gao, Shengkui. “Bio-Inspired Multi-Spectral Imaging Sensors and Algorithms for Image Guided Surgery.” 2015. Doctoral Dissertation, Washington University in St. Louis. Accessed January 21, 2021. https://openscholarship.wustl.edu/eng_etds/118.
Gao, Shengkui. “Bio-Inspired Multi-Spectral Imaging Sensors and Algorithms for Image Guided Surgery.” 2015. Web. 21 Jan 2021.
Gao S. Bio-Inspired Multi-Spectral Imaging Sensors and Algorithms for Image Guided Surgery. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2015. [cited 2021 Jan 21]. Available from: https://openscholarship.wustl.edu/eng_etds/118.
Gao S. Bio-Inspired Multi-Spectral Imaging Sensors and Algorithms for Image Guided Surgery. [Doctoral Dissertation]. Washington University in St. Louis; 2015. Available from: https://openscholarship.wustl.edu/eng_etds/118
12. Van de Bittner, Genevieve Crystal. Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease.
URL: http://www.escholarship.org/uc/item/76v708pp
► The study of biological processes involved in the development and progression of disease has the potential to uncover new treatments or cures. While there are… (more)
▼ The study of biological processes involved in the development and progression of disease has the potential to uncover new treatments or cures. While there are many techniques to study biological analytes involved in disease states, molecular imaging offers tools that are amenable to imaging biological processes as they occur in living systems. Previously developed fluorescent molecular imaging tools have lead to an improved understanding of the roles of both hydrogen peroxide (H2O2) and copper in both normal physiological processes and in disease. However, most of these tools have been limited to the study of H2O2 and copper in cells or tissues. A more comprehensive understanding of molecular disease processes involved in disease states can be gleaned by studying animal models of human disease, as the affects of the disease on the entire organism can be monitored. This dissertation describes the design, synthesis, and characterization of bioluminescent and fluorescent molecular imaging tools for the detection of H2O2 and copper, and their application to the detection of these analytes in murine models of disease. In a first demonstration, Peroxy Caged Luciferin-1 is developed using a firefly luciferin probe scaffold and utilized to monitor increased H2O2 production in androgen-sensitive prostate tumors following stimulation with a growth-inducing compound, testosterone. Using a new approach for firefly luminescence imaging, in situ formation of firefly luciferin, two unique probes, Peroxy Caged Luciferin-2 and IETDC, are developed for simultaneous imaging of H2O2 and caspase 8 activity in a model of sepsis. Development of a third luminescence-based probe for H2O2 detection, Peroxy Caged Luciferin-3, offers a tool for the detection of H2O2 in the brain of mice, with possible applications for studying H2O2 during seizure. Finally, development of a near-infrared fluorescent probe for detection of copper in vivo is discussed and applied to the detection of alterations in copper levels during the development and treatment of a murine Wilson's disease model.
Subjects/Keywords: Chemistry; bioluminescence; copper; fluorescence; hydrogen peroxide; imaging
Van de Bittner, G. C. (2012). Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease . (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/76v708pp
Van de Bittner, Genevieve Crystal. “Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease.” 2012. Thesis, University of California – Berkeley. Accessed January 21, 2021. http://www.escholarship.org/uc/item/76v708pp.
Van de Bittner, Genevieve Crystal. “Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease.” 2012. Web. 21 Jan 2021.
Van de Bittner GC. Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease. [Internet] [Thesis]. University of California – Berkeley; 2012. [cited 2021 Jan 21]. Available from: http://www.escholarship.org/uc/item/76v708pp.
Van de Bittner GC. Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease. [Thesis]. University of California – Berkeley; 2012. Available from: http://www.escholarship.org/uc/item/76v708pp
13. Wang, Ying-ting. Protein-directed synthesis of luminescent copper nanoclusters for sensing bio-molecules.
Degree: Master, Chemistry, 2018, NSYSU
► In recent years, noble metal nanoclusters have been extensively studied, while the research on copper nanoclusters is relatively rare. Gold, silver, and copper are contained… (more)
▼ In recent years, noble metal nanoclusters have been extensively studied, while the research on copper nanoclusters is relatively rare. Gold, silver, and copper are contained in the periodic table of the same group of elements. Copper is Earth-abundant, low prices and relatively friendly to humans. In this study, we direct use of pepsin as a template, so that with high biocompatibility and without additional modification. And we also use low toxicity reducing agents such as NaBH4 and ascorbic acid in the alkaline environment. Then, copper nanocluster is successfully synthesized with the excitation wavelength at 420 nm and the emission wavelength at 496 nm. It is deduced that Cu13 is the main product and uses its characteristics as a fluorescent probe. In the process, copper nanoclusters and hemoglobin were used as an IFE absorber/fluorophore pair and can be successfully used in real urine samples hemoglobin detection. This method is convenient, the detection limit of 70 nM. In addition, in different acid-base environments, the pepsin changes its structure due to the protonation and deprotonation of functional groups, resulting in a change in its fluorescence intensity. It can be used as a fluorescent probe to detect the change of pH value in the environment. The experimental results can be obtained in the linear range of pH 2.0 ~ pH 6.5, which can distinguish the difference of pH range of 0.5. After repeated regulation in the acid-base environment, they still keep high stability. After that, copper nanoclusters are used in the detection of urea, detection limit of 0.1mM, and can be successfully applied to the human urine sample. Finally, using laser scanning confocal microscopy to observe the copper nanoclusters, the fluorescence intensity of the copper nanoclusters showed an enhanced trend between pH 4.0 and pH 6.0, indicating that the copper nanoclusters have high cell penetration and high biocompatibility. Advisors/Committee Members: Cheng-Ju Yu (chair), Tai-Chia Chiu (chair), Wei-Lung Tseng (committee member).
Subjects/Keywords: fluorescence imaging; urea; hemoglobin; pH; copper nanoclusters
Wang, Y. (2018). Protein-directed synthesis of luminescent copper nanoclusters for sensing bio-molecules . (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0003118-150231
Wang, Ying-ting. “Protein-directed synthesis of luminescent copper nanoclusters for sensing bio-molecules.” 2018. Thesis, NSYSU. Accessed January 21, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0003118-150231.
Wang, Ying-ting. “Protein-directed synthesis of luminescent copper nanoclusters for sensing bio-molecules.” 2018. Web. 21 Jan 2021.
Wang Y. Protein-directed synthesis of luminescent copper nanoclusters for sensing bio-molecules. [Internet] [Thesis]. NSYSU; 2018. [cited 2021 Jan 21]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0003118-150231.
Wang Y. Protein-directed synthesis of luminescent copper nanoclusters for sensing bio-molecules. [Thesis]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0003118-150231
14. George, Jonathan. A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles.
Degree: PhD, Nuclear, Plasma, Radiolgc Engr, 2017, University of Illinois – Urbana-Champaign
► X-ray-activated photodynamic therapy (X-PDT) techniques have gained traction for its potential to impart therapeutic effects at greater depths than possible with traditional photodynamic therapy [1],… (more)
▼ X-ray-activated photodynamic therapy (X-PDT) techniques have gained traction for its potential to impart therapeutic effects at greater depths than possible with traditional photodynamic therapy [1], [2]. Interestingly, the underlying X-PDT process could also generate X-ray fluorescence (XF) with metal-based nanoparticles (NPs) and X-ray luminescence (XL), which could be used to monitor the delivery of PDT agents and the subsequent therapeutic process. This allows the possibility of using X-ray fluorescence (XFCT) and X-ray luminescence computed tomography (XLCT) to monitor the therapeutic delivery during radiation therapy. X-ray Raleigh scattering (XRS) produced by the scattered monochromatic incident X-ray can also be correlated with the data from XFCT/XLCT while X-ray transmission CT (XT CT) could provide structural information. This work demonstrates a proof-of-concept of a XF-XL -XT CT imaging platform that allows for quantitative imaging of the X-ray PDT delivery process through complementary contrast mechanisms, and demonstrates this platform’s ability to image X-PDT nanophosphors, such as Y2O3:Eu3+. This work also attempts to address the limitations of the system—sensitivity, acquisition time, and dosage—by examining how incoming X-ray irradiation schemes affect the X-ray fluorescent and X-ray luminescent yields as well as overall X-ray fluorescent image quality. Results show that choosing an optimized incident X-ray spectrum can maximize fluorescent and luminescent yields as well as improve image quality. This in conjunction with improvements in geometric efficiency through a multi-slit ring of detectors has the potential to bring the multi-modality system into a preclinical setting. Advisors/Committee Members: Meng, Ling-Jian (advisor), Meng, Ling-Jian (Committee Chair), Abbaszadeh, Shiva (committee member), Smith, Andrew (committee member), Stubbins, James F (committee member).
Subjects/Keywords: X-ray; Nanoparticle; Fluorescence; Luminescence; Imaging
George, J. (2017). A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles . (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/101107
George, Jonathan. “A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles.” 2017. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 21, 2021. http://hdl.handle.net/2142/101107.
George, Jonathan. “A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles.” 2017. Web. 21 Jan 2021.
George J. A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2017. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/2142/101107.
George J. A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2017. Available from: http://hdl.handle.net/2142/101107
15. Bixler, Joel Nathan. Multi-Scale Imaging of Respiratory Bacterial Infection Using Fiber Microendoscopy and Whole-Animal Imaging.
Degree: MS, Biomedical Engineering, 2014, Texas A&M University
► We have integrated a fluorescence microendoscope into a whole-animal optical imaging system, allowing for simultaneous microscopic and macroscopic imaging of tdTomato expressing BCG in vivo.… (more)
▼ We have integrated a fluorescence microendoscope into a whole-animal optical imaging system, allowing for simultaneous microscopic and macroscopic imaging of tdTomato expressing BCG in vivo. A 535 nm LED was collimated and launched into a 10,000 element fiber bundle can be inserted through an intra-tracheal catheter into the lung of a mouse. Fluorescence emission can either be (1) collected by the bundle and imaged onto the surface of a CCD camera for localized detection or (2) the fluorescence can be imaged by the whole animal imaging stystem providing macroscopic information. Results from internal localized excitation and external whole body detection indicate the potential for imaging bacterial infections down to 100 colony forming units. This novel imaging technique has the potential to allow for functional studies, enhancing the ability to assess new therapeutic agents. Advisors/Committee Members: Maitland, Kristen C (advisor), Yakovlev, Vladislav V (committee member), Cirillo, Jeffrey D (committee member).
Subjects/Keywords: Fluorescence spectroscopy; Bacterial Imaging; Tuberculosis; microendoscope
Bixler, J. N. (2014). Multi-Scale Imaging of Respiratory Bacterial Infection Using Fiber Microendoscopy and Whole-Animal Imaging . (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153844
Bixler, Joel Nathan. “Multi-Scale Imaging of Respiratory Bacterial Infection Using Fiber Microendoscopy and Whole-Animal Imaging.” 2014. Masters Thesis, Texas A&M University. Accessed January 21, 2021. http://hdl.handle.net/1969.1/153844.
Bixler, Joel Nathan. “Multi-Scale Imaging of Respiratory Bacterial Infection Using Fiber Microendoscopy and Whole-Animal Imaging.” 2014. Web. 21 Jan 2021.
Bixler JN. Multi-Scale Imaging of Respiratory Bacterial Infection Using Fiber Microendoscopy and Whole-Animal Imaging. [Internet] [Masters thesis]. Texas A&M University; 2014. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1969.1/153844.
Bixler JN. Multi-Scale Imaging of Respiratory Bacterial Infection Using Fiber Microendoscopy and Whole-Animal Imaging. [Masters Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153844
16. Longo, Kaitlyn M. Bimodal Approach Using Spectroscopy and Digitial Imaging to Assist Otitis Media Diagnosis.
Degree: MS, Biomedical Engineering, 2014, University of Connecticut
URL: https://opencommons.uconn.edu/gs_theses/594
► Otitis Media is defined as inflammation of the middle ear region associated with middle ear fluid. This condition typically follows an upper respiratory infection,… (more)
▼ Otitis Media is defined as inflammation of the middle ear region associated with middle ear fluid. This condition typically follows an upper respiratory infection, is commonly misdiagnosed by physicians and can potentially lead to the inappropriate use of antimicrobial agents. [1] This thesis describes the design of a novel medical device that utilized spectroscopy and digital imaging to provide physicians with a unique representation of the middle ear. Published literature has been reviewed to assess the different approaches that researchers have studied to improve the diagnosis of otitis media, where, for example, research conducted by Thorton et al. and Boppart et al. used fluorescence to identify bacteria contained in biofilms.[12,13] In addition, a population study conducted by Jensen et al. determined what the level of diagnostic certainty is in pediatric patients and determined that general practitioners had a diagnostic certainty of 58% in patients under one year of age and 73% certainty in patients over two and a half years of age.[9] Eleven subjects, each with a history of recurrent acute otitis media and requiring myringotomy and ear tube placement, were selected for study in this thesis. All subjects received a digital imaging and spectroscopy examination using the device at the time of surgery. Five excitation and illumination wavelengths were used, including white light, 385-420 nm, 450-470 nm, 520-535 nm, and 640-650 nm as well as fluorescence imaging using 425 nm and 450 nm filters. Each of the chosen wavelengths were emitted into the ear canal and tympanic membrane during a typical otoscopic examination. Signal processing techniques were also applied to isolate various regions of the tympanic membrane using MatLAB to increase the resolution of the anatomical and physiological properties of the tympanic membrane. The spectral readings between the wavelengths of 560 nm and 760 nm were plotted for each subject and were classified according to fluid retention, consistency, and vascularity. In this subject population, eight of the 22 ears were identified to be a noneffusion normal. Reflectance of keratin, cerumen, and bone, with well defined blood vessels and contrast, allowed for better characterization of the middle ear. [8] Reflectance spectra were classified according to fluid consistency and trends were determined for non effusion and effusion patients. Class one spectra were defined as tympanic membrane and canal spectra with a rapid increase in percent reflection between 575 nm and 650 nm and a rapid decrease in percent reflection between 650 nm and 750 nm. Class two spectra were defined as tympanic membrane and canal spectra with a gradual decrease in percent reflection between 575 nm and 800 nm. This novel device was successfully used to detect effusion consistency and color and it will continue to aid in the development of a new diagnostic procedure. It provides a means for the creation of a new diagnostic procedure that may be useful… Advisors/Committee Members: Tulio Valdez, Martin Cherniack, Donald Peterson.
Subjects/Keywords: Otitis Media; Otolaryngology; Digital Imaging; Fluorescence; Spectroscopy
Longo, K. M. (2014). Bimodal Approach Using Spectroscopy and Digitial Imaging to Assist Otitis Media Diagnosis . (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/594
Longo, Kaitlyn M. “Bimodal Approach Using Spectroscopy and Digitial Imaging to Assist Otitis Media Diagnosis.” 2014. Masters Thesis, University of Connecticut. Accessed January 21, 2021. https://opencommons.uconn.edu/gs_theses/594.
Longo, Kaitlyn M. “Bimodal Approach Using Spectroscopy and Digitial Imaging to Assist Otitis Media Diagnosis.” 2014. Web. 21 Jan 2021.
Longo KM. Bimodal Approach Using Spectroscopy and Digitial Imaging to Assist Otitis Media Diagnosis. [Internet] [Masters thesis]. University of Connecticut; 2014. [cited 2021 Jan 21]. Available from: https://opencommons.uconn.edu/gs_theses/594.
Longo KM. Bimodal Approach Using Spectroscopy and Digitial Imaging to Assist Otitis Media Diagnosis. [Masters Thesis]. University of Connecticut; 2014. Available from: https://opencommons.uconn.edu/gs_theses/594
17. Downie, Kelsey Jean. Live Cell Imaging of CEACAM1 Dynamics and Self-association during Bacterial Binding.
The carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a human receptor that facilitates adhesion with neighbouring cells, as well as with certain pathogens. CEACAM1… (more)
The carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a human receptor that facilitates adhesion with neighbouring cells, as well as with certain pathogens. CEACAM1 at the cell surface exists as a mixture of monomers and dimers in a heterogeneous distribution that is thought to regulate the balance of its functions, including those associated with pathogen binding. We used live cell fluorescence and homogeneous Förster resonance energy transfer (homo-FRET) microscopy on a combined total internal reflection fluorescence polarization (TIRFPM) confocal microscopy platform to investigate the distribution, dynamics, and monomer-dimer equilibrium of CEACAM1-4L-EYFP on live cells that were parachuted onto surfaces coated with CEACAM1-binding Neisseria gonorrhoea. Both CEACAM1-4L-EYFP and a monomeric mutant form of the receptor are rapidly recruited to bacteria and lead to downstream effector recruitment. Homo-FRET data indicate that wild-type CEACAM1-4L-EYFP was predominantly monomeric at bacterial contact sites. Preferential monomeric binding during bacterial adhesion controls the infection process.
Advisors/Committee Members: Yip, Christopher M., Biomedical Engineering.
Subjects/Keywords: fluorescence microscopy; CEACAM; live cell imaging; 0541
Downie, K. J. (2013). Live Cell Imaging of CEACAM1 Dynamics and Self-association during Bacterial Binding . (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/42829
Downie, Kelsey Jean. “Live Cell Imaging of CEACAM1 Dynamics and Self-association during Bacterial Binding.” 2013. Masters Thesis, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/42829.
Downie, Kelsey Jean. “Live Cell Imaging of CEACAM1 Dynamics and Self-association during Bacterial Binding.” 2013. Web. 21 Jan 2021.
Downie KJ. Live Cell Imaging of CEACAM1 Dynamics and Self-association during Bacterial Binding. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/42829.
Downie KJ. Live Cell Imaging of CEACAM1 Dynamics and Self-association during Bacterial Binding. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/42829
18. Galwaduge, Pubudu Thilanka. Optimization of two-photon excited fluorescence for volumetric imaging.
Degree: 2017, Columbia University
URL: https://doi.org/10.7916/D8MW2VN6
► Two-photon microscopy is often used in biological imaging due to its optical sectioning and depth penetration capabilities. These characteristics have made two-photon microscopy especially useful… (more)
▼ Two-photon microscopy is often used in biological imaging due to its optical sectioning and depth penetration capabilities. These characteristics have made two-photon microscopy especially useful for neurobiological studies where imaging a volume at single cell resolution is typically required. This dissertation focuses on the optimization of two-photon excited fluorescence for volumetric imaging of biological samples, with special attention to imaging the mouse brain. Chapter 2 studies wavefront manipulation as a way of optimizing two-photon excited fluorescence. We show, through numerical simulations and experiments, that the magnitude of the two-photon fluorescence signal originating from cell-sized objects can be used as a metric of beam quality. We also show that the cranial window used in mouse experiment is a major source of aberrations, which can readily be represented in the Zernike basis. Finally, we implement a modal wavefront optimization scheme that optimizes the wavefront based entirely on the magnitude of the fluorescence. Along with this scheme, Zernike functions are found to be a useful basis for correcting aberrations encountered in mouse brain imaging while the Hadamard basis is found to be useful for scattering compensation. Corrections performed in mouse brain using Zernike functions are found to be valid over hundreds of microns, allowing a single correction to be applied to a whole volume. Finally, we show that the wavefront correction system can double as a wavefront encoding system for experiments that require custom point-spread-functions. Chapter 3 aims to significantly improve the volume imaging rate of two-photon microscopy. The imaging speed is improved by combining two-photon excitation with scanning confocally-aligned planar excitation microscopy (SCAPE). Numerical simulations, analytical arguments, and experiments reveal that the standard method of combining nano-joule pulses with 80 MHz repetition rates is inadequate for two-photon light-sheet excitation. We use numerical simulations and experiments to explore the possibility of achieving fast volumetric imaging using line and sheet excitation and find that the sheet excitation scheme is more promising. Given that two-photon excitation requires high photon-flux-densities near the focus, achieving high enough fluorescence has to be balanced with restrictions placed by saturation, photodamage, photobleaching and sample heating effects. Finally, we experimentally study light sheet excitation at various pulse repetition rates with femtosecond pulses and find that repetition rates near 100 kHz allow imaging of nonbiological samples of ~200x300x300 μm3 volume at 20 volumes per second while balancing the above constraints. This work paves the way for achieving fast, volumetric two-photon imaging of the mouse brain.
Subjects/Keywords: Imaging systems in biology; Fluorescence microscopy; Physics
Galwaduge, P. T. (2017). Optimization of two-photon excited fluorescence for volumetric imaging . (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8MW2VN6
Galwaduge, Pubudu Thilanka. “Optimization of two-photon excited fluorescence for volumetric imaging.” 2017. Doctoral Dissertation, Columbia University. Accessed January 21, 2021. https://doi.org/10.7916/D8MW2VN6.
Galwaduge, Pubudu Thilanka. “Optimization of two-photon excited fluorescence for volumetric imaging.” 2017. Web. 21 Jan 2021.
Galwaduge PT. Optimization of two-photon excited fluorescence for volumetric imaging. [Internet] [Doctoral dissertation]. Columbia University; 2017. [cited 2021 Jan 21]. Available from: https://doi.org/10.7916/D8MW2VN6.
Galwaduge PT. Optimization of two-photon excited fluorescence for volumetric imaging. [Doctoral Dissertation]. Columbia University; 2017. Available from: https://doi.org/10.7916/D8MW2VN6
19. Yu, Lujia SENG. Three color super-resolution localization microscopy for optical mapping of stretched DNAs in nanochannels.
Degree: 2019, Hong Kong University of Science and Technology
URL: http://repository.ust.hk/ir/Record/1783.1-100093 ; https://doi.org/10.14711/thesis-991012730761603412 ; http://repository.ust.hk/ir/bitstream/1783.1-100093/1/th_redirect.html
► Stochastic Optical Reconstruction Microscopy (STORM) is proved to be one of greatest tools for medical and biological research which can provide images with resolution beyond… (more)
▼ Stochastic Optical Reconstruction Microscopy (STORM) is proved to be one of greatest tools for medical and biological research which can provide images with resolution beyond diffraction limit of conventional microscope. In this thesis, we developed a three color STORM system, which allows images of three different fluorescent dyes to be taken individually and simultaneously with 20 nm lateral resolution and 40 nm axial resolution. Recipe of imaging buffer is provided for the labeling fluorescent dyes CF 568, Alexa 647 and Alexa 750 to achieve stable and long-lived photo blinking. In addition, algorithms for channel alignment and de-crosstalk is applied to improve the accuracy of the system. Because the three color STORM system makes it possible to label three different targets of interest and to be observed and imaged simultaneously, the STORM system can provide precise results for colocalization calculation and DNA optical mapping in which multiple targets are needed to be studied at same time. In this thesis, 3D colocalization between PIP2a, PHB3 and PHB6 in Arabidopsis thaliana is calculated based on their super-resolution images by different colocalization algorithms. Besides, we explored the methodology for DNA optical imaging by applying microfluidic technology with the super-resolution microscopy. Lambda DNAs and HeLa cell DNAs are nick labeled with Alexa 546 and the DNA backbone is labeled with YOYO-1. Super-resolution images of the DNAs which are stretched in 20-200 nm width nanochannels are taken by the three color STORM system. Recipes of imaging buffer for different devices are provided as well. This thesis provides a design of three color stochastic optical reconstruction microscope and reveals its unique applications in colocalization analysis and DNA optical mapping to study the location and interaction of multiple targets of interest.
Subjects/Keywords: High resolution imaging ; DNA ; Analysis ; Fluorescence microscopy
Yu, L. S. (2019). Three color super-resolution localization microscopy for optical mapping of stretched DNAs in nanochannels . (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-100093 ; https://doi.org/10.14711/thesis-991012730761603412 ; http://repository.ust.hk/ir/bitstream/1783.1-100093/1/th_redirect.html
Yu, Lujia SENG. “Three color super-resolution localization microscopy for optical mapping of stretched DNAs in nanochannels.” 2019. Thesis, Hong Kong University of Science and Technology. Accessed January 21, 2021. http://repository.ust.hk/ir/Record/1783.1-100093 ; https://doi.org/10.14711/thesis-991012730761603412 ; http://repository.ust.hk/ir/bitstream/1783.1-100093/1/th_redirect.html.
Yu, Lujia SENG. “Three color super-resolution localization microscopy for optical mapping of stretched DNAs in nanochannels.” 2019. Web. 21 Jan 2021.
Yu LS. Three color super-resolution localization microscopy for optical mapping of stretched DNAs in nanochannels. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2019. [cited 2021 Jan 21]. Available from: http://repository.ust.hk/ir/Record/1783.1-100093 ; https://doi.org/10.14711/thesis-991012730761603412 ; http://repository.ust.hk/ir/bitstream/1783.1-100093/1/th_redirect.html.
Yu LS. Three color super-resolution localization microscopy for optical mapping of stretched DNAs in nanochannels. [Thesis]. Hong Kong University of Science and Technology; 2019. Available from: http://repository.ust.hk/ir/Record/1783.1-100093 ; https://doi.org/10.14711/thesis-991012730761603412 ; http://repository.ust.hk/ir/bitstream/1783.1-100093/1/th_redirect.html
20. Fedie, Joseph. Fluorescent Probe Development for Fructose Specific Transporters in Cancer.
Degree: MS, Department of Chemistry, 2017, Michigan Technological University
URL: https://digitalcommons.mtu.edu/etdr/332
► Carbohydrate transporters or GLUTs of the major facilitator superfamily (MFS) are responsible for transporting sugars into the cell and have been of research interest… (more)
▼ Carbohydrate transporters or GLUTs of the major facilitator superfamily (MFS) are responsible for transporting sugars into the cell and have been of research interest for decades. Disruptions, mutations, and over-activations of GLUTs have been linked to a number of major diseases including cancer, obesity, and diabetes. Differentiating between transporters is incredibly difficult due to highly conserved structures, and so specific targeting between transporters has proven a complex challenge. GLUTs are highly flexible in their conformations however exactly what will and will not pass through the transporter is ambiguous at best, and many attempt to target these transporters have failed. In an attempt to further understand GLUT5’s transport capacity and specificity several probes were created by conjugating 1-amino-2,5-anhydro-D-mannitol with a number of fluorescent coumarins. These probes were then tested in cancer and normal breast cell lines to determine uptake mechanisms and transport specificity. To determine transport specificity probes were tested in the presence of competitive and non-competitive inhibitors. Probe analysis was carried out by evaluating the gained fluorescence of treated cells in a microplate setting and through confocal microscopy. Confocal imaging and Z-stack was utilized to understand the ability of the probe to pass into the cytosol or to remain in the cellular membrane. As a result, probes reflecting uptake capacity vs. membrane expression of the transporter were developed. The cumulative analysis of structure-uptake relationship for the developed probes gives insight into the capability of GLUT5 cargo transport and as well as a method for imaging GLUT5 in the cellular membrane. Advisors/Committee Members: Marina Tanasova.
Subjects/Keywords: GLUTs; Cancer; Chemical Biology; Imaging; Fluorescence; Therapeutics
Fedie, J. (2017). Fluorescent Probe Development for Fructose Specific Transporters in Cancer . (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/332
Fedie, Joseph. “Fluorescent Probe Development for Fructose Specific Transporters in Cancer.” 2017. Masters Thesis, Michigan Technological University. Accessed January 21, 2021. https://digitalcommons.mtu.edu/etdr/332.
Fedie, Joseph. “Fluorescent Probe Development for Fructose Specific Transporters in Cancer.” 2017. Web. 21 Jan 2021.
Fedie J. Fluorescent Probe Development for Fructose Specific Transporters in Cancer. [Internet] [Masters thesis]. Michigan Technological University; 2017. [cited 2021 Jan 21]. Available from: https://digitalcommons.mtu.edu/etdr/332.
Fedie J. Fluorescent Probe Development for Fructose Specific Transporters in Cancer. [Masters Thesis]. Michigan Technological University; 2017. Available from: https://digitalcommons.mtu.edu/etdr/332
21. Cavins, Patrick L. Fluorine-18 capture by substituted BODIPY derivatives.
► For the medical community to effectively decrease the number of deaths caused by cancer each year, we must develop tools that allow for the early… (more)
▼ For the medical community to effectively decrease the number of deaths caused by cancer each year, we must develop tools that allow for the early detection of biological abnormalities. Earlier detection is key to increasing the survival rate among cancer patients. A major tool currently used by the medical community is molecular imaging. However, the scope of molecular imaging is limited, so new molecular imaging agents must be developed. One the most ubiquitous biological molecules are peptides, and changes in peptide expression has been associated with cancer. However, molecular imaging does not presently have the tools required to monitor the entire class of peptides. In order to increase the scope of molecular imaging in regard to peptides, we have endeavored to create a new class of peptide imaging agents based on the BODIPY fluorophore. To date, we have demonstrated the ability of this scaffold to work effectively as an imaging agent in mouse models. These dyes are lipophilic in vivo so newer generations of this scaffold will have to address these concerns. Advisors/Committee Members: Glass, Timothy (advisor).
Subjects/Keywords: Diagnostic imaging; Radiochemistry; Fluorescence; Cancer – Early detection
Cavins, P. L. (2015). Fluorine-18 capture by substituted BODIPY derivatives . (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/46845
Cavins, Patrick L. “Fluorine-18 capture by substituted BODIPY derivatives.” 2015. Thesis, University of Missouri – Columbia. Accessed January 21, 2021. http://hdl.handle.net/10355/46845.
Cavins, Patrick L. “Fluorine-18 capture by substituted BODIPY derivatives.” 2015. Web. 21 Jan 2021.
Cavins PL. Fluorine-18 capture by substituted BODIPY derivatives. [Internet] [Thesis]. University of Missouri – Columbia; 2015. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/10355/46845.
Cavins PL. Fluorine-18 capture by substituted BODIPY derivatives. [Thesis]. University of Missouri – Columbia; 2015. Available from: http://hdl.handle.net/10355/46845
22. Wang, Zhenghui. Studies of fluorescent imaging for mRNA detection in living cells.
Degree: PhD, Chemistry, 2011, Washington University in St. Louis
URL: https://openscholarship.wustl.edu/etd/663
► This dissertation focuses on the study of imaging mRNA in living cells. To achieve this research objective, three approaches have been utilized:: 1) Imaging of… (more)
▼ This dissertation focuses on the study of imaging mRNA in living cells. To achieve this research objective, three approaches have been utilized:: 1) Imaging of a transgenic mRNA tagged by multiple repeats of malachite green: MG) binding aptamer.: 2) Imaging of inducible nitric oxide synthase: iNOS) mRNA by strand-displacement activated Peptide Nucleic Acid: PNA) probes.: 3) Imaging of iNOS mRNA by binary fluorescently labeled PNA probes. The first approach was based on the work of our former lab member Dr. Huafeng Fang, who had constructed a multiple MG binding aptamer tagged transgene: Flag-mβ2AR-GFP-MGVI), which could also express a green fluorescence protein associated with an adrenergic receptor protein. It has been reported that the tagged aptamer sequence can increase the fluorescence of MG up to 2000 fold by binding to MG. Total RNA extract of the transfected MDCK cells has shown up to 22 times increase of fluorescence in the presence of MG. Confocal fluorescence imaging study has shown that in the presence of MG, cells expressing the transgene showed both the fluorescence of GFP and enhanced fluorescence of MG. A flow cytometry study detected that in the presence of MG and transfected cells showed 1.3 fold increase of fluorescence compared to the wild type MDCK cells. The next approach was to use strand-displacement activated PNA probes to detect the iNOS mRNA in living RAW 264.7 mouse macrophage cells. A probe constitutes of an antisense 23-mer fluorescein: FAM) labeled antisense PNA and a 17-mer Dabcylplus labeled complementary DNA was used. The fluorescence of the FAM was quenched when the two strands hybridized to each other. In the presence of target mRNA, the shorter strand was displaced by the mRNA, which has more base pairs complementary to the PNA. The fluorescence of FAM was restored and thus could be used to detect the mRNA. The probe has been shown to be able to detect the target DNA and in vitro transcribed mRNA in solution. Fluorescence in situ hybridization: FISH) showed that the probes showed 3.6: ± 1.8)-fold increase of fluorescence between stimulated cells expressing a high level of iNOS mRNA and non-stimulated cells. Cationic Shell-crosslinked Knedel-like: cSCK) nanoparticles were employed to deliver probes into living cells and the fluorescence of the stimulated cells observed by confocal microscopy increased 16.6: ± 7.9)-fold. RT-PCR was conducted to determine the absolute copy number of the iNOS mRNA in cells. The detected increase of iNOS mRNA after 18 hours of stimulation was around 100 times, and the actual copy number of the mRNA per cell was around 70000. These results reveal that the under our current systems, strand-displacement probes are not sufficient to report quantitatively on the mRNA copy numbers in living cells, but they can be used to achieve mRNA imaging in living cells. The third approach was to use fluorescent labeled binary PNA probes to image the iNOS mRNA in living RAW 264.7 cells. PNAs bearing FAM and Cy5 and targeting the adjacent sites of the iNOS mRNA… Advisors/Committee Members: John-Stephen Taylor.
Subjects/Keywords: Chemistry; Biochemistry; Fluorescence; Imaging; mRNA; PNA
Wang, Z. (2011). Studies of fluorescent imaging for mRNA detection in living cells . (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/etd/663
Wang, Zhenghui. “Studies of fluorescent imaging for mRNA detection in living cells.” 2011. Doctoral Dissertation, Washington University in St. Louis. Accessed January 21, 2021. https://openscholarship.wustl.edu/etd/663.
Wang, Zhenghui. “Studies of fluorescent imaging for mRNA detection in living cells.” 2011. Web. 21 Jan 2021.
Wang Z. Studies of fluorescent imaging for mRNA detection in living cells. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2011. [cited 2021 Jan 21]. Available from: https://openscholarship.wustl.edu/etd/663.
Wang Z. Studies of fluorescent imaging for mRNA detection in living cells. [Doctoral Dissertation]. Washington University in St. Louis; 2011. Available from: https://openscholarship.wustl.edu/etd/663
23. Maji, Dolonchampa. Development and applications of novel fluorescent molecular probe strategies.
Degree: PhD, Biomedical Engineering, 2017, Washington University in St. Louis
► Optical imaging and spectroscopy technologies offer the ability to provide structural and functional information in a fast, low-cost, ionizing radiation free, highly sensitive and… (more)
▼ Optical imaging and spectroscopy technologies offer the ability to provide structural and functional information in a fast, low-cost, ionizing radiation free, highly sensitive and high throughput fashion. The diverse contrast mechanisms and complementary imaging platforms form the foundation for the application of optical imaging in pre-clinical studies of pathophysiological development as well as direct clinical application as a tool for diagnosis and therapy. Fluorescence imaging techniques have been one of the most rapidly adopted methods in biology and biomedicine. Visualization of biological processes and pathologic conditions at the cellular and tissue levels largely relies on the use of exogenous fluorophores or their bioconjugates. Some fluorescent molecular probes provide usable contrast for disease diagnosis due to their responsiveness to interactions with other molecular species and/or immediate microenvironment. As a result, understanding exogenous fluorescent contrast mechanisms will allow the development of efficient strategies for biomedical fluorescence imaging. The present work focuses on exploring novel fluorescent molecular probe strategies for imaging cancer and cardiovascular diseases. We have developed a platform for synthesizing activatable fluorescent molecular probes using the fluorescence quenching properties of copper (II) ions. We used these activatable probes for rapid imaging of cancerous tissue in vivo in mice. While developing these molecular probes, we discovered an unexpected molecular interaction that yields stable dimeric molecules. This finding can potentially enable the development of new molecular entities for modifying the signaling properties of fluorescent dyes to minimize background fluorescence. Although planar fluorescence imaging methods using exogenous molecular probes provide rapid information about molecular processes in vivo, extraction of depth information require complex data acquisition and image analysis methods. By designing a dual emission fluorescent probe incorporating two spectrally different fluorophore systems, we developed a method to successfully estimate the depth of fluorescent inclusions from planar imaging data and demonstrated the potential of using this approach to locate a blood vessel and tumorous tissue in mouse in vivo. An important feature of fluorescence methods is the availability of various techniques that provide complementary information. Combining the fluorescence intensity and lifetime properties of a biologically targeted near infrared fluorescent probe, we demonstrate an effective way to distinguish specific from nonspecific uptake mechanisms in cancer cells, an approach that can be translated in vivo. Alternatively, dynamic fluorescence imaging technique expands the scope of applications to include detection and estimation of the size of circulating cancer cells and clusters. The approach developed in this work could allow longitudinal monitoring of these cells, which are implicated in cancer metastases. … Advisors/Committee Members: Samuel Achilefu, Mark Anastasio, Gregory M. Lanza, Srikanth Singamaneni, Lihong V. Wang.
Subjects/Keywords: contrast agent; fluorescence; optical imaging; Biomedical
Maji, D. (2017). Development and applications of novel fluorescent molecular probe strategies . (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/242
Maji, Dolonchampa. “Development and applications of novel fluorescent molecular probe strategies.” 2017. Doctoral Dissertation, Washington University in St. Louis. Accessed January 21, 2021. https://openscholarship.wustl.edu/eng_etds/242.
Maji, Dolonchampa. “Development and applications of novel fluorescent molecular probe strategies.” 2017. Web. 21 Jan 2021.
Maji D. Development and applications of novel fluorescent molecular probe strategies. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2017. [cited 2021 Jan 21]. Available from: https://openscholarship.wustl.edu/eng_etds/242.
Maji D. Development and applications of novel fluorescent molecular probe strategies. [Doctoral Dissertation]. Washington University in St. Louis; 2017. Available from: https://openscholarship.wustl.edu/eng_etds/242
24. Uthoff, Ross. Design of a Smartphone-Camera-based Fluorescence Imaging System for the Detection of Oral Cancer .
Degree: 2015, University of Arizona
► Shown is the design of the Smartphone Oral Cancer Detection System (SOCeeDS). The SOCeeDS attaches to a smartphone and utilizes its embedded imaging optics and… (more)
▼ Shown is the design of the Smartphone Oral Cancer Detection System (SOCeeDS). The SOCeeDS attaches to a smartphone and utilizes its embedded imaging optics and sensors to capture images of the oral cavity to detect oral cancer. Violet illumination sources excite the oral tissues to induce fluorescence. Images are captured with the smartphone’s onboard camera. Areas where the tissues of the oral cavity are darkened signify an absence of fluorescence signal, indicating breakdown in tissue structure brought by precancerous or cancerous conditions. With this data the patient can seek further testing and diagnosis as needed. Proliferation of this device will allow communities with limited access to healthcare professionals a tool to detect cancer in its early stages, increasing the likelihood of cancer reversal. Advisors/Committee Members: Liang, Rongguang (advisor), Liang, Rongguang (committeemember), Koshel, Richard J. (committeemember), Schwiegerling, Jim (committeemember).
Subjects/Keywords: illumination; imaging; mHealth; optics; Optical Sciences; fluorescence
Uthoff, R. (2015). Design of a Smartphone-Camera-based Fluorescence Imaging System for the Detection of Oral Cancer . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/593619
Uthoff, Ross. “Design of a Smartphone-Camera-based Fluorescence Imaging System for the Detection of Oral Cancer .” 2015. Masters Thesis, University of Arizona. Accessed January 21, 2021. http://hdl.handle.net/10150/593619.
Uthoff, Ross. “Design of a Smartphone-Camera-based Fluorescence Imaging System for the Detection of Oral Cancer .” 2015. Web. 21 Jan 2021.
Uthoff R. Design of a Smartphone-Camera-based Fluorescence Imaging System for the Detection of Oral Cancer . [Internet] [Masters thesis]. University of Arizona; 2015. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/10150/593619.
Uthoff R. Design of a Smartphone-Camera-based Fluorescence Imaging System for the Detection of Oral Cancer . [Masters Thesis]. University of Arizona; 2015. Available from: http://hdl.handle.net/10150/593619
25. Hirmiz, Nehad. DEVELOPMENT OF A MULTIPLEXED CONFOCAL FLUORESCENCE LIFETIME IMAGING MICROSCOPE FOR SCREENING APPLICATIONS.
Degree: 2019, McMaster University
Protein-protein interactions are important for biological processes. Therefore, many small molecules target a specific protein or interaction in the cell to have biological consequence. While… (more)
Protein-protein interactions are important for biological processes. Therefore, many small molecules target a specific protein or interaction in the cell to have biological consequence. While we can measure some protein-protein interactions in a test tube, many proteins cannot be purified making it difficult to properly test that a drug is “on target”. An alternative is to measure these interactions in live cells. We express the proteins of interest fused to fluorophores allowing the use of fluorescence techniques. Förster Resonance Energy Transfer (FRET) provides a molecular level ruler to measure the distance, within a few nanometers, between two proteins. FRET indicates binding. The gold standard for measuring FRET in live cells is by quantifying changes in fluorescence lifetime using Fluorescence lifetime imaging microscopy (FLIM). The change in fluorescence lifetime is inversely proportional to the ratio of bound to non-bound proteins. Tradition FLIM-FRET microscopy is too slow for screening applications. Our aim was to develop a highly multiplexed confocal system for rapid FLIM-FRET acquisition. We present the development of multiple prototypes for confocal multiplexing. In this work, our final design includes 32×32 multiplexed excitation points which scan the sample using refractive window scanners. We coupled this excitation scheme to a 64×32 time-gated single-photon avalanche photodiode (SPAD) sparse array detector. This multiplexed setup allows the use of the sparse array with high frame rate and sub-nanosecond time-gating to achieve high throughput FLIM acquisition. Using our multiplexed FLIM prototype we measured Bcl-2 family protein-protein interactions in live cells (310×310 μm FOV) with two-channel confocal FLIM in 1.5 s. Protein binding affinities were estimated by measuring the changes in FRET as a function of acceptor to donor ratio. The resulting speed of this system meets requirements for implementation in screening applications.
Candidate in Philosophy
Inside a cell, proteins are the “workers” and they interact with each other, doing that work. Many of these interactions are important for the cell to live. Pharmaceutical companies may design drugs that can interfere with a specific interaction in order to cause an effect in the cell. Scientists are interested in measuring these interactions and we can do this by “taking a picture” of the interaction using a specialized microscope. One of the major issues with these microscopes is that it takes scientists a long time to collect pictures of these interactions. This means only a few drugs can be tested in a day. To speed up the drug discovery and testing we want to design faster microscopes that can test hundreds of drugs in a day. In my thesis I contributed to building a state-of-the-art super fast microscope. We made progress in steps, and by the third attempt we successfully measured interactions in cells in seconds! Our new microscope is ~400x faster than current technologies. We hope that this research…
Advisors/Committee Members: Fang, Qiyin, Biomedical Engineering.
Subjects/Keywords: Fluorescence Microscopy; Confocal Microsopy; Fluorescence Lifetime; Rapid Imaging; Drug Screening
Hirmiz, N. (2019). DEVELOPMENT OF A MULTIPLEXED CONFOCAL FLUORESCENCE LIFETIME IMAGING MICROSCOPE FOR SCREENING APPLICATIONS . (Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/25137
Hirmiz, Nehad. “DEVELOPMENT OF A MULTIPLEXED CONFOCAL FLUORESCENCE LIFETIME IMAGING MICROSCOPE FOR SCREENING APPLICATIONS.” 2019. Thesis, McMaster University. Accessed January 21, 2021. http://hdl.handle.net/11375/25137.
Hirmiz, Nehad. “DEVELOPMENT OF A MULTIPLEXED CONFOCAL FLUORESCENCE LIFETIME IMAGING MICROSCOPE FOR SCREENING APPLICATIONS.” 2019. Web. 21 Jan 2021.
Hirmiz N. DEVELOPMENT OF A MULTIPLEXED CONFOCAL FLUORESCENCE LIFETIME IMAGING MICROSCOPE FOR SCREENING APPLICATIONS. [Internet] [Thesis]. McMaster University; 2019. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/11375/25137.
Hirmiz N. DEVELOPMENT OF A MULTIPLEXED CONFOCAL FLUORESCENCE LIFETIME IMAGING MICROSCOPE FOR SCREENING APPLICATIONS. [Thesis]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/25137
26. Cheng, Xiaoyu. Colloidal Silicon Quantum Dots: From Preparation to the Modifications of Self-Assembled Monolayers for Bio-applications.
Degree: Chemistry, 2015, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/54301 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:34724/SOURCE02?view=true
► Quantum dots (QDs) are semiconductor nanocrystals with unique photophysical properties. Quantum dots have drawn broad research interests in the past three decades, because of their… (more)
▼ Quantum dots (QDs) are semiconductor nanocrystals with unique photophysical properties. Quantum dots have drawn broad research interests in the past three decades, because of their applications in optoelectronic devices, solar cells and fluorescent imaging agents in biomedicine. However, a major issue for the further development of this new class of materials is that many quantum dots are composed of heavy metal elements that are considered unsafe for biological purposes. Therefore, concerns over nanoparticle related toxicity have inspired the design of quantum dots made from materials with biological benign nature, such as crystalline silicon (Si).The first challenge of working with nanocrystalline silicon quantum dots (SiQDs) is the limited methods available to prepare high quality, surface functionalized nanoparticles. Among the various methods available, colloidal synthesis is of broad interests, for the simple procedures used and solution-based approaches as needed in many applications. In this thesis, chapter three and chapter four describe two new approaches of coping with this challenge, using a one-step method based on thiol-ene chemistry, and a two-step process based on copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction respectively.The second challenge of applying solution synthesized SiQDs for bio-imaging is their blue photoluminescence that can be affected by biological background signals, as well as the low excitation wavelength that may induce damage to cellular structures. Most responses to this challenge have been focused on material preparation, but limited success has been achieved when solution syntheses are involved. In this thesis, chapter five presents a completely different strategy of resolving this issue by focusing on advanced microscopy. Specifically, fluorescence lifetime imaging microscopy (FLIM) is used to observe SiQDs in intracellular contexts, utilizing their long fluorescence lifetime in the context of one-photon FLIM, two-photon FLIM and energy transfer studies (FLIM-FRET).Lastly, since surface modified colloidal SiQDs is still in its infancy of development, there are still limited studies showing their applications as biosensors. In chapter six, efforts toward the preparation of the first SiQDs protease sensor is described. This is based on Förster Resonance Energy Transfer (FRET) process involving SiQDs-dye construct, where SiQDs were used as the donor, and conjugated to an organic dye acceptor via an enzyme responsive peptide linker. Advisors/Committee Members: Gooding, J. Justin, Chemistry, Faculty of Science, UNSW, Reece, Peter, Physics, Faculty of Science, UNSW, Katharina, Gaus, Faculty of Medicine, UNSW.
Subjects/Keywords: Materials; Fluorescence; Cancer; Quantum Dots; Nanoscience; Nanoparticles; Surface Modification; Imaging; Fluorescence
Cheng, X. (2015). Colloidal Silicon Quantum Dots: From Preparation to the Modifications of Self-Assembled Monolayers for Bio-applications . (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/54301 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:34724/SOURCE02?view=true
Cheng, Xiaoyu. “Colloidal Silicon Quantum Dots: From Preparation to the Modifications of Self-Assembled Monolayers for Bio-applications.” 2015. Doctoral Dissertation, University of New South Wales. Accessed January 21, 2021. http://handle.unsw.edu.au/1959.4/54301 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:34724/SOURCE02?view=true.
Cheng, Xiaoyu. “Colloidal Silicon Quantum Dots: From Preparation to the Modifications of Self-Assembled Monolayers for Bio-applications.” 2015. Web. 21 Jan 2021.
Cheng X. Colloidal Silicon Quantum Dots: From Preparation to the Modifications of Self-Assembled Monolayers for Bio-applications. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Jan 21]. Available from: http://handle.unsw.edu.au/1959.4/54301 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:34724/SOURCE02?view=true.
Cheng X. Colloidal Silicon Quantum Dots: From Preparation to the Modifications of Self-Assembled Monolayers for Bio-applications. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/54301 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:34724/SOURCE02?view=true
27. Li, Zheng. HIGH-THROUGHPUT FLUORESCENCE MICROSCOPY FOR AUTOMATED CLINICAL APPLICATIONS.
Degree: PhD, 2017, University of Oklahoma
► Fluorescence in situ hybridization (FISH) is a powerful tool for visualizing and detecting genetic abnormalities. Manual scoring FISH analysis is a tedious and labor-and-time-consuming task.… (more)
▼ Fluorescence in situ hybridization (FISH) is a powerful tool for visualizing and detecting genetic abnormalities. Manual scoring FISH analysis is a tedious and labor-and-time-consuming task. Automated image acquisition and analysis provide an opportunity to overcome the difficulties. However, conventional fluorescence microscopes, the mostly used instrument for FISH imaging, have deficiencies. A multi-spectral image modality must be employed in order to visualize fluorescently dyed FISH probes for analysis, and the existing technologies are either two expensive, too slow, or both. Aiming at upgrading the current employed cytogenetic instrumentation, we developed a new imaging technique capable of simultaneously imaging multiple color spectra. Using the principle, we implemented a prototype system and conduct various characterization experiments. Experiment results (<1% peripheral geometric distortion, consistent signal response linearity, and ~2000 lp/mm spatial resolution) show no significant compromise in terms of optical performance. A detector alignment scheme was developed and performed to minimize registration error. The system has significantly faster acquisition speed than conventional fluorescence microscopes albeit the extra cost is quite insignificant. Advisors/Committee Members: Liu, Hong (advisor), Zheng, Bin (committee member), Li, Shibo (committee member), Sluss, James (committee member), Cheng, Qi (committee member).
Subjects/Keywords: Fluorescence Microscopy; Fluorescence in situ hybridization; Microscopic Imaging; Automated Microscopy
Li, Z. (2017). HIGH-THROUGHPUT FLUORESCENCE MICROSCOPY FOR AUTOMATED CLINICAL APPLICATIONS . (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/50778
Li, Zheng. “HIGH-THROUGHPUT FLUORESCENCE MICROSCOPY FOR AUTOMATED CLINICAL APPLICATIONS.” 2017. Doctoral Dissertation, University of Oklahoma. Accessed January 21, 2021. http://hdl.handle.net/11244/50778.
Li, Zheng. “HIGH-THROUGHPUT FLUORESCENCE MICROSCOPY FOR AUTOMATED CLINICAL APPLICATIONS.” 2017. Web. 21 Jan 2021.
Li Z. HIGH-THROUGHPUT FLUORESCENCE MICROSCOPY FOR AUTOMATED CLINICAL APPLICATIONS. [Internet] [Doctoral dissertation]. University of Oklahoma; 2017. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/11244/50778.
Li Z. HIGH-THROUGHPUT FLUORESCENCE MICROSCOPY FOR AUTOMATED CLINICAL APPLICATIONS. [Doctoral Dissertation]. University of Oklahoma; 2017. Available from: http://hdl.handle.net/11244/50778
28. Sharma, Robin. In vivo two-photon ophthalmoscopy: development and applications.
► Light-sensitive molecules such as rhodopsin present in photoreceptors are responsible for detecting light and subsequently initiating multi-step biochemical cascades, namely phototransduction and the visual cycle.… (more)
▼ Light-sensitive molecules such as rhodopsin present in photoreceptors are responsible for detecting light and subsequently initiating multi-step biochemical cascades, namely phototransduction and the visual cycle. Many retinal diseases are known to be caused by a breakdown of these cascades, making them prime targets for ongoing vision restoration efforts although it has been notoriously difficult to observe their activity during light and dark in the living eye. Additionally, on its way to the photoreceptors, light has to propagate through the neurons responsible for transmitting this information to the brain. These cells are naturally translucent and although they are implicated in many diseases, current imaging techniques have been unable to image these retinal layers at a cellular scale. The neural circuitry in the retina that allows us to see is complicated, spanning across several cellular layers. Most of what we know about retinal circuitry is from electrophysiology but newer methods need to be developed to accurately measure neuronal responses in the intact, living eye with minimal visual stimulation. The goal of this work is to see the cells that allow us to see, and to develop a way to track the activity of the retina at a cellular scale in the living eye. All cells in the retina contain endogenously fluorescent molecules that are natural markers for cell health and physiology but their fluorescence cannot be accessed through conventional imaging methods because their excitation spectra lie in the ultraviolet regime outside the spectral transmission window. To target these molecules in the living eye, we have developed adaptive optics assisted two-photon fluorescence ophthalmoscopy for mouse and monkey animal models. Initially, the feasibility of tracking retinal function with this method was demonstrated with exogenous fluorophores that are sensitive to changes in intracellular calcium concentration. Next, these were deployed in the unlabeled retina to indirectly track the regeneration of rhodopsin in photoreceptors by monitoring autofluorescence from molecules involved in the visual cycle. Also, by utilizing the intrinsic contrast offered by endogenous fluorophores, two-photon imaging has also enabled visualization of various retinal structures that are otherwise invisible. With advancement of this technology, it could be used for accelerating vision restoration methods and clinical diagnostics.
Subjects/Keywords: Adaptive optics; Fluorescence; Retinal imaging; Two-photon imaging; Visual cycle
Sharma, R. (2015). In vivo two-photon ophthalmoscopy: development and applications . (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/30289
Sharma, Robin. “In vivo two-photon ophthalmoscopy: development and applications.” 2015. Doctoral Dissertation, University of Rochester. Accessed January 21, 2021. http://hdl.handle.net/1802/30289.
Sharma, Robin. “In vivo two-photon ophthalmoscopy: development and applications.” 2015. Web. 21 Jan 2021.
Sharma R. In vivo two-photon ophthalmoscopy: development and applications. [Internet] [Doctoral dissertation]. University of Rochester; 2015. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1802/30289.
Sharma R. In vivo two-photon ophthalmoscopy: development and applications. [Doctoral Dissertation]. University of Rochester; 2015. Available from: http://hdl.handle.net/1802/30289
29. Philp, Lauren. Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers.
Treatment of endometrial cancer consists of surgery ± adjuvant therapy depending on lymph node involvement determined by lymphadenectomy. Targeting lymphadenectomy to patients with known metastases… (more)
Treatment of endometrial cancer consists of surgery ± adjuvant therapy depending on lymph node involvement determined by lymphadenectomy. Targeting lymphadenectomy to patients with known metastases would provide diagnostic and therapeutic benefits while reducing morbidity. Porphysomes are self-assembling nanoparticles made from a multifunctional porphyrin-lipid monomer (pyrolipid) which accumulate preferentially in malignant tissue. Pyrolipid is created through an acylation reaction during which isomerization can occur. A VX2 model of endometrial cancer with retroperitoneal metastases was used to investigate the accuracy of pre-operative 64Cu-Porphysome-enabled PET imaging of lymph nodes and the sensitivity / specificity of in-vivo porphyrin-fluorescence image-guided lymphadenectomy. Pharmacokinetic, biodistribution and biodegradation studies were used to determine differences in Sn1 and Sn2 isomeric Porphysomes. This study demonstrated that Porphysomes are a highly sensitive imaging tool to diagnose primary tumour, metastatic lymph nodes and intra-abdominal metastases and that Sn2 pyrolipid is the optimal isomer for clinical translation due to the preferential biodegradation profile.
Advisors/Committee Members: Bernardini, Marcus Q, Medical Science.
Subjects/Keywords: Endometrial Cancer; Fluorescence Imaging; Lymphadenectomy; Metastasis; Molecular Imaging; Nanoparticle; 0574
Philp, L. (2018). Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers . (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91426
Philp, Lauren. “Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers.” 2018. Masters Thesis, University of Toronto. Accessed January 21, 2021. http://hdl.handle.net/1807/91426.
Philp, Lauren. “Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers.” 2018. Web. 21 Jan 2021.
Philp L. Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Jan 21]. Available from: http://hdl.handle.net/1807/91426.
Philp L. Towards Clinical Translation of the Porphysome: Establishment of Endometrial Cancer Applications and Investigation of Metabolic Differences in Pyrolipid Isomers. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91426
30. Lacy, Jessica. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.
Degree: Doctor of Medicine, 2014, Harvard University
URL: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616
► Poly(ADP-ribose)polymerase-1 and -2 (PARP1/2) are nuclear proteins involved in DNA repair. Tumors with defects in homologous recombination, including BRCA1- and BRCA2-deficient cancers, have been shown… (more)
▼ Poly(ADP-ribose)polymerase-1 and -2 (PARP1/2) are nuclear proteins involved in DNA repair. Tumors with defects in homologous recombination, including BRCA1- and BRCA2-deficient cancers, have been shown to be sensitive to PARP inhibition. The Weissleder group has synthesized fluorescent and radioactive derivatives of the PARP1/2 inhibitor AZD2281. We hypothesized that fluorescent and radioactive AZD2281-based imaging agents would quantify PARP1/2 expression in vitro and in vivo. To test this hypothesis, a panel of pancreatic ductal adenocarcinoma and ovarian carcinoma cell lines were characterized by immunocytochemistry for PARP1/2 expression. AZD2281-derived fluorescence signal correlated with anti-PARP antibody fluorescence signal strength in vitro. Four cell lines representing a range of PARP1/2 expression levels were then xenografted into Nu/Nu mice. Mice bearing four tumor types each were imaged with AZD2281-derived imaging agents, sacrificed, and their tumors excised for stand-alone imaging and Western blot. AZD2281-derived signal correlated with tumor PARP1/2 expression determined by Western blot, indicating that PARP1/2 expression level is a determinant of fluorescent signal strength and SUVs of AZD2281-derived agents in vivo. These data indicate that AZD2281-derived agents are useful tools for quantifying intracellular PARP1/2 both in vitro and in vivo, which could one day enable prospective identification of tumors likely to respond to PARP inhibitors.
Subjects/Keywords: PARP; BRCA; PET imaging; PET/CT imaging; fluorescence microscopy
Lacy, J. (2014). Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes . (Doctoral Dissertation). Harvard University. Retrieved from http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616
Lacy, Jessica. “Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.” 2014. Doctoral Dissertation, Harvard University. Accessed January 21, 2021. http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616.
Lacy, Jessica. “Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes.” 2014. Web. 21 Jan 2021.
Lacy J. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. [Internet] [Doctoral dissertation]. Harvard University; 2014. [cited 2021 Jan 21]. Available from: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616.
Lacy J. Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes. [Doctoral Dissertation]. Harvard University; 2014. Available from: http://etds.lib.harvard.edu/hms/admin/view/58 ; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616
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3DS: Friend Codes on First Page, OMG THE THIRD DIMENSION
By The Damned,
January 19, 2011 in Community
Bleck
M. Bison (+7000)
so many psps
Mirby 177 posts
The Damned 158 posts
Malaki-LEGEND.sys 144 posts
ocre 133 posts
Brithor
Meat Boy (+250)
Very surprised it is released in Europe two days before it's released in America.
We still get shafted with the price, though... 250€ is way more than $250...
Chernabogue
Vampire Variations Trilogy Director, Legacy Co-Director
Just wanted to post this. 250€... It's more expensive than a 1st edition PS3.
I'll probably pick one up at some point. Way too many good titles to ignore. New Paper Mario game, Kingdom Hearts: 3D, OoT... I'm hoping for a new Metroid title.
Heart of a Gamer Director, The Missingno Tracks Director
You guys had problems with the shoulder buttons? Mine have always worked fine. GBA, DS Phat, DS Lite... If anything, I find the A and B buttons, especially the B button, to give out first. They still work, but they aren't as clicky as the other ones.
Gollgagh
Samus Aran (+8000)
mine have always failed at some point
3 GBAs, 2 GBA SPs, 2 DS Lites, and finally my DSi
My DS Lite works perfectly, other than a reduced battery life due to the sheer amount of use it's seen. I even dropped it on a tile floor once and it suffered nothing more than a couple of cracks on the outer casing.
Of course, battery life is something that isn't quite as good with the 3DS. But compare it to the PSP2 or whatever they're going to call it, and it suddenly seems a lot longer. Same goes for the high price. I think Sony just shot themselves in the foot. Again.
I was under the impression that none of the specs of the rumored PSP2 were known. How can you say that the 3DS battery will seem much better than something no one knows anything about?
Not to mention that there haven't even been rumors for a price range.
I'm perfectly willing to admit that I could be wrong. I was told this information by a person who doesn't generally spout rumors as fact, so... I dunno. Although if you compare last generation to this generation, it isn't too implausible to think that the PSP2 will be less affordable and have less battery life than its Nintendo-produced competition.
DarkeSword
Judge, Moderator, For Everlasting Peace Director
Sure, but the fact remains that there is practically no information about PSP2 out there. Let's leave comparisons for when we can actually reference facts, not what someone told you.
theshaggyfreak
Metal Slug (+900)
So far the only one to fail on me is my old DS lite. One of the hinges cracked which seems to happen to a lot of people. I think the oldest Gameboy that we have working in this house is a GB Pocket which still works great.
I can not understand who you people have all these damaged or flawed DSs and GameBoys. I've dropped mine, slid them across concrete, hell, I once dropped my GBA SP down the concrete stairs of an office building. It went down one flight, bounced across the gap between the stairs (it was on something like the 20th floor, so that drop would have definitely killed it) and then went down another flight just to add some more "oh shit, NOOOOOO!" for me.
I picked it up and it was still running. I have it sitting in my desk drawer next to me.
Maybe you guys just have terrible luck or something. My portable have never had problems.
Imagist
Or maybe YOU have the luck of the GODS!
[insert cheesy movie soundtrack increasing suspense]
If you'll notice, I'm only complaining about the shoulder buttons
everything else (including switch and contact-pad face buttons) has maintained funtionability
My DS Lite's L button has been shot for awhile. Probably too much Earthbound and Castlevania, which basically can require you to press L repeatedly for the majority of the game. Other than that, I've never had any problems with my Nintendo handheld gaming systems. My PSP, on the other hand, has had multiple issues over the year that is was still working.
Either way, I think the only reason I'm considering getting a 3DS on day one now is to beat a potential hardware shortage. I don't have much interest in the "launch window" games.
I can not understand who you people have all these damaged or flawed DSs and GameBoys.
If you do a search on google, you'll find a ton of people with DS Lites who have a broken right hinge. It's a stress fracture from them making the hinge have such a tight fit. People speculate that is why the DSi has a loose feel to it in comparison.
I'm actually pretty damn careful with my handheld systems. If I travel with them, they are in a case if I'm not playing them. My PSP has one of those wrap around cases since I managed to get a slight scratch on the screen right after I got it. Luckily those scratches can be taken out. Being the OCD person that I am, I couldn't deal with it being there.
Ryu Hayabusa (+2300)
I don't carry my DS in my pocket that often, nor my GBA SP. I put them in a safe place in my back-pack, well-protected.
But again and again, it's ALWAYS the L button that goes out. I've went through 3 DS lites (2 through warranty, thank God) because of faulty shoulder buttons. And I had to go through another one because the touch screen of one completely fizzled out. And it fizzled out playing Trace Memory for goodness' sake! There is absolutely no heavy touch-screen action in Trace Memory!
Kirby (+1500)
Okay, I just realized something about the battery life.
Nintendo is including that charging cradle, and they've stated that they intend for you to keep it in sleep mode indefinitely. Basically, you play it for 3 or 4 hours that day (Really, how COULD you play it for longer in a day?) and rest it in it's cradle overnight. Voila, it's charged and ready for the next day.
Huh. I guess Nintendo outsmarted us
I'm still hoping that the battery life can be longer with changing the settings.
I don't know about you, but I don't think I would have StreetPass and SpotPass on all the time. I'm only going to have it running when I go around town.
HalcyonSpirit
Yoshi (+1400)
Nintendo estimates that the battery life of the 3DS can be extended to up to 8 hours just by turning the 3D off, and turning the wireless settings off, dimming the screen, and putting it into a power-saving mode should all help to extend it even further.
http://kotaku.com/5738668/short-cords-long-friend-lists-and-other-burning-3ds-questions-answered
Nabeel Ansari
Pikachu (+5000)
Do want.
It'll probably be a while before I can muster up the money, but I think it'll be worth it.
Toadofsky
Chun-Li (+1000)
I withdraw my thoughts on Pilotwings Resort. From the sound of it right now (could be wrong) there's only three types of flight. No birdman from the sound of it, or no parachuting or the plethora of things they had in either the Super NES or N64 games. If they think $40 bucks is worth that, they're nuts. And even lazier than I thought.
Edited January 21, 2011 by Toadofsky
On-topic comic.
Be Aggressive! Co-Director
I lol'd.
But yeah, I'm kicking that cost back a bit by selling my DSi. I'm sure plenty of other people will be doing the same.
Anyone remember that Dead or Alive clip that had them fighting in a pit with Ridley flying around, and then at the end, Samus pops out in her morphball mode and then it fades to white?
Sorry guys.
http://www.eurogamer.net/articles/2011-01-24-samus-not-playable-in-dead-or-alive-3ds
It would have been cool, but I guess Samus only throws down in Smash Bros.
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Indians stranded in Canada wants to get back to India
Vande Bharat Mission has been started from May 16-22. Indian high commissioner Ajay Bisaria has stated that 5,000 Indians has been registered their names to get back to India in phase 2. The high commission has been announced five flights for Canada.
Three flights will evacuate people from Toronto, two from Vancouver. According to the report, there are 700,000 Indian citizens in Canada, and 225,000 of them are students. There are 300,000 permanent residents are living in Canada; 160,000 residents with work permits, business and tourist visa holders got stranded.
Shiv Sena’s war on Modi government – India will break like the Soviet Union if the conspiracy does not stop
India has been exported Hydroxycholroquine to Canada. They are co-operating with each in the pharma sector. The Prime Minister Narendra Modi has been talked Prime Minister of Canada Mr Justin Trudeau. They’ve been discussed over the exit plan, how to recover from the crisis amid pandemic.
Indians who have been stranded in Indonesia, Thailand, Australia, Italy, France, Germany, Ireland, Canada, Japan, Nigeria, Kazakhstan, Ukraine, Kyrgyzstan, Belarus, Georgia, Tajikistan and Armenia, will be brought back to India in Phase 2 of Vande Bharat Mission.
DU में ऑनलाइन ओपन-बुक परीक्षा के आचरण का सुझाव
लॉकडाउन के दौरान दिल्ली में चौथी बार महसूस हुए भूकंप के झटके
Know who is RCP Singh, who got the responsibility of JDU President
The JDU executive meeting was held in Patna today after the Janata Dal United (JDU )'s poor performance in the...
Indian Railways: Trains will not be delayed due to fog, there will not be an accident; Special Device ready
Railways have made special preparations to ensure that the train is not late due to fog. From the railway, trains...
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Flying Advice from an Expert
I’ve given my recommendations for flying apparel, but here is another physician’s. Dr. David Aranoff, director of the division of infectious disease at Vanderbilt University Medical Center gave this advice in a recent article in the Wall Street Journal.
Flying Soon? Here’s the Covid Safety Gear You Do—and Don’t—Need.
Online retailers are touting all kinds of protective gear for germaphobic travelers. While fliers really need to wear some of them, others just constitute overkill.
Barbara Peterson
Updated Oct. 9, 2020 4:19 pm ET
FLIERS ASSEMBLING their travel wardrobes these days face vexing questions: What kind of mask do I need? Should I invest in a face shield or goggles? Traveler’s safety gear comes in a wild assortment of styles—and prices—ranging from a plain 10-cent paper face mask to a $250 head-to-waist hazmat suit, complete with helmet, anti-fogging mask and built-in air purifier. There are Grateful Dead face masks, hot-pink jumpsuits, Space Age shields with bandannas dangling like goatees. Not all airlines are onboard with the fashion show: Air France, for example, only permits a standard-issue surgical mask—no cute cloth masks allowed. Other carriers frown on those Ghostbusters-style jumpsuits. But other than the obligatory face covering, does any of this paraphernalia make you safer, or is it just plague chic? Here, a rundown of flight gear that’s selling online, with notes from medical experts on relative effectiveness.
Face coverings, now mandatory on virtually all flights, come in three basic flavors: cloth masks that can prevent you from spreading the virus; surgical masks, which offer wearers some protection from other people’s germs; and the gold standard, the N95 version, which can block up to 95% of microbes, but is meant primarily for healthcare workers. How does each hold up in an aircraft cabin? “Comfort is important,” said Dr. David Aronoff, director of the division of infectious diseases at Vanderbilt University Medical Center, who also serves on a health advisory panel for American Airlines. “Try to find one that doesn’t dig into your face, and can last throughout the flight.” Dr. Ravina Kullar, infectious diseases specialist and epidemiologist based out of Los Angeles, said that a cloth mask with at least two layers has been shown to be highly effective for non-healthcare workers. “If you can hold the cloth face mask against a light and the light is able to get through, it is not thick enough,” she said. The CDC also says to avoid masks that have valves or vents, which make it easier to breathe but could allow virus particles to escape.
Bottom line: The disposable surgical mask as well as a cloth mask with at least two layers will do the job, according to Dr. Aronoff and the CDC. But check the fit to make sure there aren’t any gaps on the sides.
Since infections could also be spread if droplets land in one’s eye, medical professionals use wraparound goggles when caring for a patient suffering from Covid-19 or other infectious diseases. Now, some airlines, including United and Korean Air, are providing flight attendants with safety goggles, so the traveling public might be wondering if they should follow their lead. “They’re not necessary for routine travelers,” said Dr. Aronoff, though if you’re eager for additional protection—because you’re at higher risk of falling dangerously ill from Covid-19 or simply nervous about flying—then there’s no harm in wearing goggles.
Bottom line: Not essential, but if you want to be extra safe, go for it.
When model Naomi Campbell posted a photo showing her clad in a head-to-toe protective jumpsuit in-flight, social media went wild. (It looked arguably better on her than it might on the rest of us.) Proper versions are like hermetically sealed space suits, designed to protect workers in a disaster like a chemical cleanup or nuclear accident. But these days you can find dubious lightweight disposable models, including a cotton-candy pink one on Amazon for $21.
What are you wearing to stay safe while flying? Join the conversation below.
Airlines and medical professionals aren’t enthusiastic. “Entire suits seem to me to be over the top,” said Dr. Aronoff. “It’s hard to see the benefit.” Even worse, added Dr. Kullar, “they may cause fear in other fliers,” which explains why some airlines are considering banning them.
Bottom line: Leave the hazmat suits to those with hazardous jobs. Simply change out of your flying clothes as soon as you arrive at your destination.
Clear plastic face shields are, let’s face it, pretty strange-looking, but they’re becoming more popular, and are even required on flights with some airlines like Qatar and Philippine. They help protect you from a “direct inoculation from someone right nearby,” said Dr. Aronoff. He believes that face shield designs that include a cloth that hangs down to the wearer’s neck are “probably very effective.” But isn’t a shield overkill if you’re already required to wear a mask? If someone feels more comfortable and protected bolstering her mask with a face shield, said Dr. Gendreau, “that’s fine but it’s not a major improvement.”
Bottom line: Much like goggles, face shields afford extra protection but aren’t critical for most fliers.
Disposable gloves were a popular accessory early in the pandemic, but the CDC doesn’t recommend them, noting that they’re not necessary for the general public in most situations and improperly taking them off could actually spread germs if you’re touching contaminated surfaces. “There is no role for gloves in preventing the spread of Covid-19,” said Dr. Aronoff. “It’s important that people understand that we do not get infected through our skin.” (The virus is transmitted if you touch an infected surface, then touch your nose, mouth or eyes.) Dr. Aronoff recommends, instead, practicing good hand hygiene and avoid handshakes and other direct contact. Dr. Mark Gendreau, chief medical officer at Beverly and Addison Gilbert Hospitals, near Boston, agrees: “Gloves give you a false sense of security and actually lead to more contamination. We actually frown on people wearing gloves in the hospital.”
Bottom line: Don’t bother.
Category: COVID-19By Mark Thornton October 13, 2020
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A year of change starring PJ Harvey, Outkast, Bright Eyes, Lauryn Hill, and more
Graphic by Martine Ehrhart
In retrospect, 1998 feels like a music year in transition. In the mainstream, the surge of “alternative” music energy that had powered the first half of the ’90s was starting to fizzle; grunge had been fully co-opted, and nü-metal was ascendant. The tide of the CD boom was still lifting all boats, even as Napster and mp3s were right around the corner, and teen pop was about to have its big moment. Mixtapes were still being traded and everyone had a cassette deck, perhaps the last one they would ever own. Below the radar, the underground was healthy: Independent labels were roaring, and some of the bigger ones were still living large on the cash they’d made earlier in the decade, when they served as farm teams for major-label-bound acts. Out in the world, fans were starting to build communities electronically—including those reading a two-year-old electronic zine called Pitchfork—and Google would debut later in the year. And there were many great records that stuck with us, that defined this era and remained timeless.
Experiencing music in 2018 means being bombarded with new and rediscovered music simultaneously. Here at Pitchfork, now that we’re 22 years young, we thought it would be fun to look at the albums of 1998 and rank our favorites. Our voters for the list were a mix of those who were engaged critically with music that year and those who’ve learned about much of it in hindsight. (And some of our favorite releases from the year—including DJ Shadow’s Preemptive Strike, the Beta Band’s The Three EPs, and Stereolab’s Aluminum Tunes—were excluded because they were collections of material released earlier.) Here’s how we hear 1998 now.
Listen to selections from this list on our Spotify playlist and our Apple Music playlist.
Rap-A-Lot
It’s difficult for rap to sound timeless. The genre changes with the wind and, as a result, its most exciting artists often burn bright and fast. Rappers from hip-hop’s earlier days may have been foundational, but their sound can feel dated. If you have any doubt, ask Lil Yachty what he thinks of Biggie.
But then there’s Devin the Dude, the cover of whose self-titled debut album featured him sitting on the toilet, smoking a joint, and reading the newspaper like the carefree legend he was. Sounding like a muppet with a cold, the Houston-based Devin raps about his devotion to marijuana and watching the world go by. The beats are slinky funk, as Pharrell as they are Funkadelic. It’s a singular album, a delightful listen that carves out a hip-hop niche still his own two decades later. –Matthew Schnipper
Listen: Devin the Dude, “Sticky Green” [ft. Scarface]
Windy & Carl
In the 1980s and early 1990s, dream-pop and shoegaze taught listeners that sweet melodies could be cloaked in tendrils of swirling noise. Windy Weber and Carl Hultgren were drone explorers who took that notion a step further, conducting atmospheric guitar drifts that maintained both structure and sweeping emotion. Their fourth album and Kranky Records debut, Depths, veers between ethereal instrumentals and hazily murmured songs—a bit like Deerhunter’s Cryptograms-era interludes mixed with Grouper’s abstract lullabies, to name two Kranky signees that followed. Depths is 70 minutes in length—with little more than guitar, bass, voice, and who knows how many effect pedals—but Windy & Carl fill up their vast canvas with coolly shimmering tones too songlike to be conventionally ambient, too ambient to be conventionally songs. Like certain paintings in the modern art wing of a museum, it might look like an undifferentiated block of color from a distance, but it’s endlessly absorbing once you’ve stepped in close. –Marc Hogan
Listen: Windy & Carl, “Undercurrent”
Gee Street
Bobby Digital in Stereo
RZA’s first solo album came from a forsaken place. After dedicating years of his life to defining the Wu-Tang Clan’s grainy aesthetic, the rapper and producer born Bobby Diggs grew dismayed when his crew started to splinter. Faced with such ungratefulness, he thought, “Let me show these motherfuckers.” His anarchic alter ego was born.
A hood superhero in a dollar-store party mask, Bobby Digital’s origin story involves honey-dipped blunts and a quest to offer internet access to poor neighborhoods worldwide. (He once said the whole idea “came from a really good bag of weed.”) During this period of indulgence, RZA’s fantasies blurred into his real life, to the extent that he claimed to have actually spent hundreds of thousands of dollars on a bomb-proof Digimobile as well as a crusader’s outfit that could repel machine gun bullets. Bobby Digital in Stereo is full of boasts so outlandish, they might give Diddy pause, instead of offering the sorts of philosophical bars RZA was known for. And the beats trade out some of his signature grit and sampling for bizarre keyboard bleeps and bloops, making the album something of an outlier amid the expanded Wu universe. It’s a barrage of psychedelic id from one of the decade’s most potent eccentrics. –Ryan Dombal
Listen: RZA, “Domestic Violence”
Saddle Creek
Letting Off the Happiness
Before Conor Oberst fell into Americana, he was a teenager in his bedroom etching raw, unearthly songs into a four-track tape machine. Released when he was 18 years old, Bright Eyes’ first proper studio album, Letting Off the Happiness, pried open the psyche of a kid who already felt the worse for wear. The songs that aren’t about death and dying tend to be about paralyzing loneliness and troubled relationships: Oberst is abandoned by his friends on “Contrast and Compare.” He’s taking too many pills and seeing dead babies in the bathroom on “Padraic My Prince.” He’s sleeping with someone he’d really rather not be sleeping with on “A Poetic Retelling of an Unfortunate Seduction.” Though his lyrics aligned with common emo sentiment, Oberst favored keyboards and tape loops over electric guitars, rendering Letting Off the Happiness a strange electroacoustic rag doll of disparate styles and techniques. His lyrics and the raw desperation in his voice struck a nerve among his fellow sad teens, many of whom might have been learning for the first time that music didn’t have to be polished or palatable. It could be a deranged document of your worst fears strung together in a basement on ramshackle equipment, just so long as it rang true. –Sasha Geffen
Listen: Bright Eyes, “Contrast and Compare”
Touch and Go
In an Expression of the Inexpressible
With In an Expression of the Inexpressible, Blonde Redhead rid themselves of the downtown grit embedded in their earlier work, and they began to draft a more romantic and uncharacteristically lustrous version of the Sonic Youth mimesis of their first three albums. Blonde Redhead's signature remains their symbiosis, and their tight-knit songwriting was already apparent here—lead guitarist and vocalist Amedeo Pace and drummer Simone Pace are twin brothers; Amedeo and rhythm guitarist/lead vocalist Kazu Makino were in love.
For In an Expression, the group found a kindred spirit in producer Guy Picciotto, who himself had transitioned from the scrappy, guttural output of Rites of Spring to the more austere punk of Fugazi. The tumbling percussion on “Suimasen” and “Luv Machine,” the pulsing guitar harmonies on “Led Zep,” the desperate wails on the title track—they would have suited Blonde Redhead’s previous records, but here they were executed with new finesse. Together, the four put a finer focus on their erratic, eccentric tunes, making In an Expression sound intentional and brilliant. –Claire Lobenfeld
Listen: Blonde Redhead, “Luv Machine”
Mille Plateaux
Königsforst
Outside Cologne, a woodland called Königsforst encompasses 7,500 acres of tall, skinny trees and tranquil bodies of water. As a teenager, the Kompakt co-founder and minimalist techno pioneer Wolfgang Voigt wandered this terrain while tripping on acid. The best known of his many aliases, GAS, approximates that experience. By layering stretched-out samples of German classical music over 4/4 kick-drum beats, Voigt unites the majesty of nature and the weight of tradition with the physicality of the club. The intoxicating results are slow and fast, meditative and propulsive, timeless and futuristic at once.
Although the entire GAS oeuvre is rooted in Königsforst, the album that bears its name is the most reflective and organic of Voigt’s many releases under the moniker. Each track conjures a different forest landscape: “Königsforst 1” throbs with the exhilaration of a sunrise run, static crunching like autumn leaves underfoot. The swollen strings of “Königsforst 3” have the foreboding aura of a journey into the darkest reaches of the woods. And the awe-inspiring “Königsforst 5” captures the GAS ethos in miniature, a pas de deux between distorted horns and insistent drums that dissolves into a swirling, psychedelic reverie. –Judy Berman
Listen: GAS, “Königsforst 1”
Disco edits have long been the secret weapon of club DJs; these specially spliced takes of familiar tunes bear the DJ or producer’s own sensibilities, offering up versions that can only be heard when that talent is on the decks. Detroit’s Theo Parrish revealed himself to be an idiosyncratic craftsman of these from the start, his early singles full of wobbly yet entrancing edits that strayed from archetypal house music towards old funk, soul, and jazz. First Floor, Parrish’s debut album, takes the disco edit into heady new territory, shipping the likes of Luther Vandross, Nina Simone, and James Brown into spacey new surroundings. As he loops lithe basslines, needling guitar licks, head-nodding electric organ chords, and famous guttural shouts to the point of mesmerism, Theo isn’t content to just pay tribute to the past. Rather, he reveals that there was always plenty of space between house, acid, and techno for electronic music producers to move about. –Andy Beta
Listen: Theo Parrish, “Sweet Sticky”
Embrya
The term “neo-soul” was only a few years old by 1998, but the genre’s biggest stars were already feeling boxed in by it. Perhaps none were quite as pigeonholed as Maxwell, whose 1996 debut, Maxwell’s Urban Hang Suite, was a magnet for comparisons to Marvin Gaye, Prince, and Stevie Wonder—none of them inaccurate, per se, but collectively they cast an impression of the singer as a standard-issue revivalist. With his dense, divisive sophomore outing, Embrya, Maxwell made it clear that he wasn’t trying to recreate his influences: He was trying to top them.
A paradox of easy grooves and difficult accompaniments, composed as if repurposed from fragments of far less cluttered songs, Embrya confounded critics and listeners alike with its new age spiritualism, florid production, unhurried pacing, and submerged melodies. Every track is swollen past the seams with flourishes. There’s a magnificently seductive three-and-a-half-minute song at the core of “Everwanting: To Want You to Want,” but the song rides out for twice that length, letting each of Maxwell’s session musicians get a few extra licks in. Yet as ponderous and unabashedly pretentious as Embrya could be, even at its slowest, it absolutely knocks, thanks to the bottomless basslines that reverberate through the wah-wah guitars, clipped horns, flutes, and celestial strings that cushion the most remote crevices of these songs. Even when Maxwell was trying to challenge the masses, he sounded gorgeous doing it. –Evan Rytlewski
Listen: Maxwell, “Everwanting: To Want You to Want”
Mouse on Mars
By 1998, the German production duo Mouse on Mars had established themselves with three full-lengths that mixed techno, dub, pop, and ambient. Jan St. Werner and Andi Toma’s music was shimmery and bright and often a little goofy, marking them as playful electronic experimenters who colored well outside the lines. For Glam, they tried something different. Originally commissioned and then rejected as a soundtrack for a widely panned and rarely seen film (it starred Tony Danza, which was a more interesting factoid 20 years ago), Glam veers from wispy new age to jet-black dark ambient to crunchy industrial. Foregoing their song-oriented approach for immersive exercises in mood and shade, St. Werner and Toma wound up with an ambient masterpiece that is still their finest record. –Mark Richardson
Listen: Mouse on Mars, “Glim”
Sketches for My Sweetheart the Drunk
Jeff Buckley has been thoroughly deified in the two decades since he died, but he has also been minimized—his creativity condensed into haunted eyes and high cheekbones, that sky-piercing vocal on “Hallelujah,” and a fateful accident. But Buckley was too swift a mind, too keen an ear to be boxed in; when he drowned at age 30, midway through the sessions for his second album, he left a dozen paths still to explore. Folk martyrdom was the least of them.
Buckley, then a modest success, probably would have done a lot of paring and pruning before releasing My Sweetheart the Drunk; as its rough etchings suggest now, he was ferocious with ideas still unfurling. Where his debut, Grace, was a savvy braiding of psychedelic hard-rock, minimalist pop balladry, and grunge ardor, the Sweetheart sessions stew with more heat and less cohesion, delighted in the avant-garde eccentricity culled from downtown New York clubs. (Leonard Cohen never covered Genesis by yodeling about a “fluffy heart” and porcupines over a scrum of atonal guitars.) It’s odd to reconcile Buckley’s pristine popular legacy with hearing him trill through the prog thrum of “The Sky Is a Landfill,” purr through the ominous madrigal “You & I,” and torch Nirvana guitar riffs in “Nightmares By the Sea.” But his pop ear endures, too, in bare moments like “Everybody Here Wants You,” a balletic soul jam. It’s heartbreaking that so many doors were open to him, now forever shut. –Stacey Anderson
Listen: Jeff Buckley, “The Sky Is a Landfill”
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The Belle
Willie Moore, Jr.
Darlene McCoy
Radio One Richmond Community Page
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Ava DuVernay Talks Filmmaking, Putting Women In Their “Rightful Place” In The Civil Rights Movement [VIDEO]
NewsOne Now
Roland Martin talked with Ava DuVernay, director of “Selma,” about the critically-acclaimed film and how she became a director during a recent press event.
DuVernay, whose path to the director’s chair followed a nontraditional path, said she started in the business doing something completely different before she decided to try her hands at directing.
The self-taught motion picture director told Martin, “What I was doing as a publicist made good money. It was a cool job, but there was a desire that was put in my heart and I think that when we have those desires they are definitely gifts to us and they’re gifts from above and if you can pursue it, you should.”
DuVernay has only been directing for five years and never went to film school. She explained to Martin that she learned her craft from watching DVD commentaries, Q&As and reading books. Her study has obviously paid off because DuVernay has been nominated for Best Director honors by the Golden Globes and is the first African American woman to receive a nomination in that category.
NewsOne Now Exclusive: Common Reveals How ‘Selma’s’ ‘Glory’ Came To Be [VIDEO]
“Rose In A Fisted Glove”: Carmen Ejogo On The Role Of Coretta Scott King In ‘Selma’ [VIDEO]
Actor David Oyelowo Shares His Views On ‘Selma’ And 7-Year Journey To Play The Role Of MLK [VIDEO]
Oprah Talks ‘Selma’: Critically Acclaimed MLK Biopic Was “Ordained” [VIDEO]
According to reports, “Selma” was made for $20 million, which is a budget that she is not used to. DuVernay who is used to producing film projects with a much small budget said she was accustomed to making movies with “$2 and a paperclip and a gum wrapper.”
“That’s the spirit of Black folk, making something out of nothing, making beauty where there is not beauty and finding it, finding the joy in doing it.”
She told Martin, “$20 million for someone like me is definitely huge. $20 million to other film makers wasn’t enough, but also I won’t be coy, I had never worked with that amount of money. So for me to image that $20 million wasn’t enough to tell a story, I could not fathom why that would be the case.”
DuVernay also shared her desire to tell the story of the women of the Civil Rights movement who were “relegated to the margins” in history books.
Women like Ella Baker, Fannie Lou Hammer, Diane Nash and others were a “centrifugal force to everything that happened during the Civil Rights movement. It is criminal that they have been left out of so many major texts and major creative illustrations of the time,” said DuVernay.
She continued, “It felt like righting a wrong in some way, women were there, I’m a woman filmmaker, there’s no way I’m making this film without the ability to make sure that we in our rightful place.”
Watch Martin and “Selma” director, Ava DuVernay discuss the critically acclaimed film, how the movie relates to present day struggles for justice and recount major Civil Rights icons, Rep. John Lewis and C.T. Vivian visiting the set of the movie in the video clip above.
Be sure to listen to “NewsOne Now” with Roland Martin, weekdays at 7 a.m. EST and watch at 9 a.m. EST on TV One.
Subscribe to the “NewsOne Now” Audio Podcast on iTunes.
Ava DuVernay Talks Filmmaking, Putting Women In Their “Rightful Place” In The Civil Rights Movement [VIDEO] was originally published on newsone.com
Ava DuVernay , C.T. Vivian , civil rights , Diane Nash , Ella Baker , Fannie Lou Hammer , golden globes , Rep John Lewis , Roland Martin , Selma
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Miley Cyrus’ Mom Called Her a ‘Bratty Millennial’ For ‘Serving Content’ on Vacation
Chelsea Lauren, Getty Images
Miley Cyrus has been living it up on vacation in Utah with her mom Tish and her sister Brandi, and anyone who follows her on Instagram knows this because she's shared 12 posts since yesterday (September 25) documenting her posing on cliffs, kayaking, hanging out with her dog Bean and lounging by the pool.
Though we love the pop star's infinite content her mom, as moms do, scolded her daughter for spending too much time on social media instead of truly experiencing her surroundings. Not one to get easily ashamed (or heed her mother's words), the singer shared Tish's lecture on her Instagram story.
"My mom called this 'disgusting'," she wrote over a photo of herself scrolling on her phone. "There was a gorgeous sunset and I was inside on my phone 'serving content'...It's hard to get in trouble once you're an adult but she said I looked like a 'bratty millennial' which I do...but is it bad if I like the pic and wanna post? Is that the worst? @tishcyrus."
Goes to show, momma doesn't care how famous you are. She's still gonna call you out when she feels so compelled.
The trip is a much needed one for Cyrus, who reportedly split from her girlfriend Kaitlynn Carter last week and is in the midst of a divorce from her husband Liam Hemsworth.
Celebrity Kids Who Look Exactly Like Their Famous Parents
Filed Under: Miley Cyrus
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Community Writing
PolitiZoom
Trump Brags About His “SS” Doesn’t Know That It’s Not the Same As Hitler’s, Apparently
Ursula Faw
Another day, another gaffe from the Know Nothing in Chief. This one’s a doozy.
Our great National Guard Troops who took care of the area around the White House could hardly believe how easy it was. “A walk in the park”, one said. The protesters, agitators, anarchists (ANTIFA), and others, were handled VERY easily by the Guard, D.C. Police, & S.S. GREAT JOB!
Translation: "While I was sobbing until a table in my bunker, my goons gassed one of the priests of St. John's church and other unarmed protesters, including senior citizens, and beat up an Australian news crew. They don't call me Chickenfeathers McCrimespree for nothing."
— Walter Shaub (@waltshaub) June 11, 2020
Wow. Trump just tweeted that the peaceful protestors around the White House were handled very easily by the S.S. The S.S., otherwise known as the Schutzstaffel, was Adolf Hitler’s paramilitary group of the Nazi Party. It was led by Heinrich Himmler and was pure fucking evil.
— Eugene Gu, MD (@eugenegu) June 11, 2020
Nobody refers to the Secret Service as the S.S. in this sensitive context and situation unless they are doing it intentionally to troll people. Just like Trump’s rally in Tulsa on Juneteenth, Trump only seeks to inflame tensions and instigate harm. That’s irresponsible as hell.
That’s not the only place Trump is inflaming tensions. News of his resuming rallies, at a time when the COVID-19 crisis has by no means been eliminated, also show that he’s tone deaf to the issue, no matter how loudly America screams at him from the streets. CNN:
Donald Trump will return to the 2020 campaign trail on June 19 in Tulsa, Oklahoma, a move freighted with racial symbolism and one almost certain to end poorly for the incumbent president.
The selection of Tulsa as the place where Trump returns to the stump and the date on which he is choosing to do it both suggest that Trump’s long-whispered-about race speech — in the wake of ongoing protests and unrest following the death of George Floyd — will happen next Friday, and at a campaign rally no less.
—Tulsa was the site of one of the most vicious acts of racial violence in American history when, in 1921, a mob of white people attacked a section of the city known as Greenwood or “Black Wall Street” and murdered hundreds of African Americans. (The event was the basis for HBO’s “Watchmen” series.) And June 19, which has become commonly known and celebrated as Juneteenth, or Emancipation Day, commemorates the anniversary of the reading of the General Orders, No. 3, which officially informed slaves that they were free
Its hard not to see this as intentional by the Trump campaign. While Oklahoma has no set limit on group gatherings, it’s not a swing state, so there’s no other obvious reason — other than to address racial issues — that Trump would stage his first rally in the state (and Tulsa particularly). And Trump could have done the rally on lots of days — 364 of them actually! — that don’t commemorate the emancipation of slaves.
If I had to make a prediction at this point, I would say that this latest media stunt on Trump’s part is going to backfire, and it’s only a question of how spectacularly. I suspected that he was going to couple the long awaited race and unity speech with a campaign rally, that’s a no brainer. But whatever theatricality he has planned for next week in Tulsa, I think may end up being the St. John’s church debacle, redux.
It’s becoming apparent at this point that Trump only functions within the confines of his bubble and when the inhabitants there don’t get the results he wants, he goes bonkers and hires outsiders to pander to his need to hear the chorus of approvals which right now don’t exist. This staged event in Tulsa has all the earmarks of a Trumpian circus act, which he thinks will bring the house down — and may just tank his approval ratings further. I’m willing to bet he hasn’t even thought of that.
Only one thing is certain and you know this already: Trump cannot play it straight. It isn’t in him. He is a showman and a conman, first last and always. It’s all a game. The time has actually passed when he could have made any kind of a unity speech that might have mattered. Next week will be a joke, and if these bizarre tweets of the past few days are any indication, Trump may be a lot farther gone than even what is obvious.
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Mama says stupid is as stupid does. Forrest Gump
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turber9
He is a tone-deaf idiot, plain and simple.
Cherl Harrell
Lol, of course he hasn’t thought of how it will lower his approval ratings! Everything he does is perfect, right? I am willing to bet this will be bigger and better than the stunt at the church.
Bareshark
Now with three times the COVID 19 infections!
Tin woman1
He is very disturbed.
Disturbed is one thing. Not knowing the difference between the Shulzstaffel and the Secret Service is something very different.
And so the cycle begins anew. Anyone who wanted to break out of it has long since fled the scene. We keep doing our part, Trump is doomed.
Lil Blue Sock
With Goebbels wanna be Stephen Miller writing a speech on race relations what could possibly go wrong???
*smirk*
“Ya sure you used enough dynamite there, Butch?”
dana fairfield
Of course he abbreviated Secret Service. Trump is extremely sensitive to character count. By abbreviating Secret Service, he has exactly 280 characters. However, it is amazing how often his reptilian brain creates these little scandals. He could just have easily not written “Troops,”and replaced “and others” with “etc” and he would have been home free. But he just has to put out the bait, and we take it every time. I doubt the Tulsa rally was his idea—probably some sick adviser like Miller, but I don’t doubt once someone explains how the mere announcement of the event “owns the libs,”… Read more »
At this point, I doubt ANY idea about his campaign comes from him. I do wonder if the person who suggested the time and place of this rally was doing deliberate sabotage from the inside, though.
Disagree. Go look at the tweet. He wrote S.S. — ess period ess period. He could have written USSS, which is proper, United States Secret Service and avoided all this. I don’t think it was character count, I think it was deliberate — and I’m not the only one who picked up on this. This opinion is all over Twitter.
The opinion being all over twitter does not transform the opinion into a fact.
We have seen Trump would never think ahead to avoid anything. It could be deliberate. When he is running out of characters, he creates all kinds of strange abbreviation. The presence of only one plausible abbreviation in a tweet with plenty of editing room lends credence to deliberation.
“Rules? There are no rules in a knife fight”.
Paraphrase from the Untouchables: “Isn’t that just like a Republican…brings a knife to a gun fight…”
He’s thanking the SS already?
I can’t agree more. The truth is not only stranger than fiction, it’s one hell of a lot funnier.
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Contact us: contact@politizoom.com
Joseph "Murfster35" Murphy - January 21, 2021
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A New Type of Rotary Club
ReLife School Renovation
Little Free Library Locations
Charter Celebration
Little Library Project
Our Club Members at Play
Our Club Members at "Work"
Club Updates (9/24/2020)
A few updates and information for our club that I would like to pass along.
We still have three meetings which will need a program. If you have an idea of a program or a speaker that you would like to invite, please let me know. (2nd Wednesday of the month)
Rotary focus meetings - Is there a Rotary topic that you would like to learn more about? Please let me know. I am working on finding speakers/programs for the Rotary focus meetings (4th Wednesday of the month)
Make sure to check out the calendar for our meetings coming up
For those that have pledged a donation during a meeting for our 50/50 drawing, please make sure to pay your invoices. You should have received an invoice via email. You can also find your current balance in your club runner account by logging in to the 'member area' and then click on 'MyClubRunner' in the top navigation which will open a second row navigation. From there you can click on 'my account balance' which will provide your open balance. You can pay via credit card through the site.
Rotary Passport Club of Pierce County
A new type of club for our community. Becoming a Rotarian connects you with a diverse group of community leaders who share your drive build friendships, give back, and make meaningful business connections.
Rotary brings together a global network of leaders who dedicate their time and talent to tackle local and global humanitarian challenges. With more than 1.2 million members from more than 200 countries, Rotarians enjoy being "at home" wherever they are in the world.
For more information about service projects, becoming a member or questions about our club contact us!
P.O. Box 111674, Tacoma, WA United States 98411
All materials and photos, unless otherwise specified, copyright of Rotary Passport Club of Pierce County.
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Home Dispatches Occupy and Abolish ICE
Occupy and Abolish ICE
George Ciccariello-Maher explains how Occupy ICE has heightened contradictions between the proclamations of "sanctuary" by elected officials and their actually existing policies of repressing protest.
by Sarah Jaffe
Around the country, as the demand to abolish ICE spreads, occupations of its offices are springing up. In many of the cities where such occupations exist, they have heightened contradictions between the proclamations of “sanctuary” by elected officials wanting to look progressive, and those officials' actual policies of repressing protest. George Ciccariello-Maher, an activist and academic, has taken part in the Occupy ICE encampment in Philadelphia and joins me to discuss the evolution of the tactic and demand, the relationship of movements to self-proclaimed progressive mayors, and more.
Outtakes:
I think we are used to abolitionist language seeming really extreme or long-term or pie in the sky, and yet, we have seen this claim take root and spread. Partly because of the real brutality of what ICE is doing and the transparency of what is going on.
It is also really important to remember that one of the first things I think we should do as analysts, but also as movement organizers is to historicize, to think about the fact that ICE is not that old. ICE is a new institution. ICE has not been around very long. Abolishing it really should not be that difficult. That points both towards the potential and the possibility of this claim to actually come about. I think that is why you see many Democrats, or some Democrats at least, talking about the abolition of ICE, but it also points toward the dangers because we are in a strange situation where you are talking about abolishing something, but it is really just an intermediate demand because the last thing we want is to see ICE simply replaced by INS, by Border Patrol doing the same exact work or going back to an old status quo which is not good enough for us.
We need to be very careful to tether the demand to abolish ICE to the demand to not replace it. This is actually what a lot of Democrats have been insisting on, “We will find a better replacement.” No. We don’t want any replacement for this. We want to roll back the powers that have been granted even to Border Patrol in recent decades and the dramatic expansion of that agency and the dramatic expansion of its budget and expansion of its ground force on the border. We want a radical transformation, ultimately, that points toward border abolition by the end.
Interviews for Resistance is a syndicated series of interviews with organizers, agitators and troublemakers, available twice weekly as text and podcast.
Sarah Jaffe is an independent journalist covering labor, economic justice, social movements, politics, gender, and pop culture. She is a Nation Institute fellow, author of Necessary Trouble: Americans in Revolt, and runs the podcast series Interviews for Resistance. Find her on Twitter at @sarahljaffe.
Activism Democrats Dispatches Immigration
Sarah Jaffe is a regular contributor to The Progressive and a reporting fellow at the Type Media Center, covering labor, economic justice, social movements, politics, gender, and pop culture. Find her on Twitter at @sarahljaffe.
Read more by Sarah Jaffe
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Rare Digital Art by MakersPlace
The official Rare Digital Art publication by MakersPlace. Discover the latest news and updates on rare digital art and MakersPlace.
🔥 Drops
Rare Art Market
Drops, MakerStories, Uncategorized
SSX3LAU and The Future of NFTs
3LAU and Slimesunday Join Forces to Introduce A New Kind of Digital Creation
The boundaries of art have never been clearly defined. Throughout history, the art of music, theater, and creative writing have often intertwined, leaving audience members with a melting pot of sensations and reactions. However, in comparison, visual arts such as painting, photography and sculpture have often stood in solitude throughout the history of collaboration. Yet this, and almost everything about today’s current art world, is changing.
As we move towards a new way to create and consume art in the digital age, it makes perfect sense that the historic lines dividing art forms into categories are disappearing. The rise of rare digital art has given way to new forms of artwork which prioritize creating true experiences over fitting within a genre or category.
This blending of boundaries is at the center of the artworks created by SSX3LAU, a collaborative art project between electronic dance music DJ and producer 3LAU and world renowned collage artist Slimesunday. Together the pair has introduced a number of immersive audiovisual artworks that combine mediums of music and visual art to create full-on experiences that speak to multiple senses.
3LAU, or Justin Blau, is a Las Vegas based DJ and Electronic Dance Music producer who has created a number of worldwide house music hits such as Is It Love, Better With You, Touch, and Tokyo. He’s also created a number of remixes for artists like Rihanna, Katy Perry, Shawn Mendes, and Ariana Grande — all of which have racked up millions of streams. 3LAU’s music blends electronic genres of house and dubstep, and is known for his melodic, ethereal take on dance music, and has 2 million monthly listeners on Spotify.
In more recent years, Blau has become a strong advocate for blockchain amongst musicians and the EDM community. His interest in blockchain and cryptocurrency has blossomed into a number of amazing projects including the first music concert to feature ticketing powered by the Ethereum blockchain back in 2018, alongside musicians Zedd and Big Sean.
3LAU is amongst one of the first mainstream musicians to fully embrace blockchain and the possibilities it offers by creating some of the first ever “rare digital art” tracks. The popularity and demand for these tracks should come at no surprise.
Slimesunday
Slimesunday is a Boston-based digital artist who is known across the world and web for his provocative collage artworks which unapologetically push the barriers of mainstream media and censorship.
His artworks fully embraces human sexuality and the beauty and sensuality of the bare human form, while also incorporating elements of irony, artistic puns and social commentary.
Creating artwork on blockchain is a relatively new endeavor for Slimesunday, who was introduced to the new medium and market earlier this year. He sees this as a new opportunity to express his true creative passions, without having to play the Instagram popularity game. His artwork on blockchain differs from his traditional digital collages in the level of personal expression and vulnerablity.
His artworks have been well received amongst art enthusiasts globally through his Instagram, which hosts the bulk of his portfolio, amassing over 522k followers. Slimesunday’s art can be found in Playboy, Penthouse, Hunger, Plastik, and Glamour Magazine.
SSX3LAU
SSX3LAU is a collaborative project between the two creators, which audio and visual art to bring forth a series of highly immersive creations. Through the artworks of SSX3LAU, the duo seeks to explore the intersection of digital art, dance music, and distributed ledger tech in audio / visual space. Rather than focus solely on the music, or the visuals, 3LAU and Slimesunday aim to combine the two, providing a new level of experiential artwork.
The duo has been collaborating on creative projects for over five years now. Creating and distributing their artworks on Blockchain is a relatively new endeavor for the duo, despite both having been interested/exploring the space individually since its inception.
Like many creatives during this time, 3LAU and Slimesunday faced a number of artistic limitations presented by the Covid pandemic. Creating on the blockchain has completely changed the duos’ process and end result, opening the door to new opportunities that would otherwise seem impossible in our current socially distanced state. Creating on Blockchain has presented a novel means of reaching their audiences, new and existing, as well as a complete shift in what they are actually creating.
While both continue to create individually in their respective art forms, the two have now joined forces to blend visual and audio, thereby introducing a new form of creation to the world. Both undeniably masters of their craft, 3LAU and Slimesunday seek to harmoniously combine their creative specialties, to create high impact, highly immersive experiential artworks.
We were lucky enough to have a conversation with 3LAU and Slimesunday to learn more about their creative journeys, the birth of SSX3LAU and their thoughts on the blockchain art movement.
Listen to the full interview below:
Traffic is the first series of artworks by SSX3LAU on MakersPlace. The duo will be introducing a collection of three new artworks. One static piece and two audiovisual pieces, each of which is heavily infused with a sense of rhythmic responsiveness, prompting a visceral reaction from viewers. By combining sounds with sights, 3LAU and Slimesunday seamlessly pull us into their world, allowing us to truly immerse ourselves and feel the artwork.
Your Ticket to the First-ever SSX3LAU VR Set
The lucky owners of each artwork will receive exclusive access to a virtual performance by the duo, which will be hosted at the 3LAU HAUS – an almost identical replication of Blau’s home in Las Vegas. This exclusive event marks another “first” in both the decentralized world of NFT collecting and the general world of art consumption.
“CHROMA expresses the infinite potential of & boundless synergy between distributed ledger technology & art.”
Worlds collide, destruct and are reborn in this thought-provoking 3D still which highlights the ever-evolving nature of our current worlds, both virtual and physical.
Price: 0.35 ETH (~$200) (The final edition will be auctioned)
View full artwork>>
“GreenWood explores our deep connection with the natural world as technological dependency engulfs our everyday lives during this time of crisis.”
Static Preview Only
The healing properties of nature have become a salient force to many of us during these trying times, including 3LAU and Slimesunday. This audiovisual seeks to celebrate and replicate the feelings of peace and calm associated with nature, and serves as a reminder of its importance and power especially in the technological age.
Price: 2.35 ETH (~$1,400) (The 10th and final edition will be auctioned)
“Traffic explores a crossroads between the metaverse & reality through organized chaos.”
This 1/1 artwork aims to highlight this sentiment through visual symbolism and auditory storytelling which places the viewer at the scene, ready to zoom off into what the future may hold.
Edition of One
Only accepting offers
* Auction closes at 7pm PST the following day.
If you’re a digital creator, you can learn more about MakersPlace here.
Ready to start your rare digital art collection? Join here.
Follow us on Discord, Twitter, Medium, Instagram, Facebook and Pinterest.
December 3, 2020 December 4, 2020 featured
Published by aisha_arif
View all posts by aisha_arif
Previous Previous post: SSX3LAU – Slimesunday x 3LAU
Next Next post: Upcoming Drops —Mark McKenna, José Delbo and Silvana Delbo
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Nigerians are stellar students at U.S.-based Bowie University – officials
Olori Wuraola confirms split with Ooni of Ife
We’ll focus on grassroots devt. projects in next 2 years, says Gov. Bindow
Gov. Mohammed Bindow of Adamawa said on Tuesday his administration would in the next two years focus attention on developmental projects in rural areas.
Bindow made this known in Yola at the swearing-in ceremony of 50 Development Area Administrators.
“The time to concentrate on grassroots governance has come. I urge the newly sworn-in administrators to maintain fairness to people at the grassroots.
“I want to assure the people that more infrastructural projects will be allocated to the rural areas within the remaining two years.
“My administration had concentrated development in the Jimeta-Yola metropolis and 12 other local government areas,’’ he said.
He explained that his administration decided to concentrate on providing infrastructure in the state capital in order to develop the area.
Speaking earlier, Alhaji Abdulrahaman Jimeta, the Chief of Staff to the governor, had urged the administrators to be loyal to their council chairmen.
Jimeta also reminded the administrators that the scope of their job was purely political, and advised them not to encroach on the day-to-day administration of the councils.
Alhaji Sulaiman Garba, the Administrator, Belel Sarau Development Area of Maiha Local Government Area, expressed appreciation to the governor for finding them worthy to serve in that capacity.
Speaking on behalf of his colleagues, Garba assured the governor that people at the grassroots were being sensitised to the significance of the policies and programmes of his administration to their living standard.
The Adamawa government had in the past passed a law creating development areas from the existing local government areas in the state. (NAN)
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Hand Carved Slate Tombstones, & Plaques, Carved with Chisel and Mallet
Hand Carved Slate Tombstones, & Plaques, Carved with Chisel and Mallet Hand Carved Slate Tombstones, & Plaques, Carved with Chisel and Mallet Hand Carved Slate Tombstones, & Plaques, Carved with Chisel and Mallet
Hand Drawn & Hand Carved Letters
Each stone is carved with careful attention to detail the same way it has been carved for thousands of years, all with Chisel and Mallet. Each letter is lettered by Hand, no computers, stencils or templates. Hand Carved stones reach a level of crispness and clarity that modern techniques have a hard time achieving.
Gallery of some of David's work
The oldest dated stones in America are Slates from the 1650s
why slate?
Quite simply, because it lasts. Cemeteries are full of Marble stones from the 1860s that are unreadable with huge letters but when you see slates from the 1760s whose letters are shallower, thinner and as crisp as the day they were carved, I think you will agree.
J. David Gillespie, Slate Tomb and Grave Stone Cutter
David Gillespie was trained person to person with only traditional methods and techniques. David has been carving slate gravestones since 2003. He has had commissions as far North as Connecticut and as far South as Edisto Island South Carolina. He has been commissioned for stones to go into Historic, Private and Modern Cemeteries. He has been commissioned for works in Municipalities, The Congressional Cemetery in Washington DC, and Drayton Hall Plantation, Charleston SC.
David has been selected as one of America's Best Craftsmen, & Listed in Early American Life Magazine, in the Directory of Traditional American Crafts, where the judges are Museum Curators, and Historic Material Culture Professionals from all across the US.
David has had commissions as far North as Connecticut and as far South as Edisto Island South Carolina. He has been commissioned for stones to go into Historic, Private and Modern Cemeteries. He has been commissioned for works in Municipalities, The Congressional Cemetery in Washington DC, and Drayton Hall Plantation, Charleston SC.
David uses only the best slate which is monument grade and listed as unfading. Colors for monuments can be Blue Black, Green or Purple. in North America. Predominately he uses Buckingham Slate, from Virginia. It is a true Unfading slate that has been quarried since the late 1700's and even Thomas Jefferson Used it for his building projects. Buckingham Slate is used on Ford's Theatre in Washington, D.C. and The Smithsonian Castle.
One of the first Americans to recognize the value and architectural beauty of slate in the United States was that master architect Thomas Jefferson. Geologist W. Rogers reported to Virginia Legislature that, "In texture, density and capacity of resisting atmospheric agents, it can scarcely be excelled by a similar material in any part of the world." He further recorded the use of Buckingham® Slate (still serviceable today) on the University of Virginia, specified by Thomas Jefferson for roof covering.
My Process to Commission a Stone
Please Click the Link Below to See my process and more of your questions can be answered about how to commission your own Stone that should last for hundreds of years.
Great for use for design ideas!
Our Book on 18th Century Gravestones
David's book "A Brief Treatise on Tomb and Grave Stones of the 18th Century" is perfect as a "design catalog" for you to gain many ideas for your own stone project. $19.99 and click below to buy it now or to see more details.
Introduction to Slate Gravestones
Check out this great video!
David Gillespie
A Native of South Carolina, David has been carving slate gravestones since 2001. He and his wife Renee also set up at Reenactments and are period Sutlers selling wares of the 18th Century. David is also a Portrait Miniature Artist.
Renee Gillespie
Renee Gillespie is a Native of Pennsylvania and holds a Bachelors of Arts from Washington College of Chestertown, MD. She is an accomplished Indigo Dyer and Paper Marbler as well.
James Gillespie
Is David's Father and our Bowl maker expert. He makes all manner of wooden Treenware such as Bowls, Bread boards, Rolling pins and Trenchers.
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The NRMA traces its heritage back to 1920 and for the last 100 years has been focussed on keeping Australians moving.
It’s a focus unswayed even by the pandemic.
NRMA has resilience woven through its DNA; and has in recent years substantially enhanced its digital resilience, implementing robust technology foundations with performance and security front and centre.
Chris Swadling is the Senior Manager of Infrastructure at NRMA. He says his team’s role is; “To make sure that our systems are secure, functioning, and performing so that our people can best serve our members and customers.”
It’s a typically laconic response that NRMA members are familiar with – the sort of ‘I’m just doing my job’ comment you might expect from a Roadside Service Patrolman rescuing you and your family from a cold rainy night stuck on a freeway hard-shoulder.
The NRMA Group today though extends far beyond roadside assistance and includes businesses such as Thrifty Australia and New Zealand, My Fast Ferry, Fantasea and Australian Tourist Park Management. The organisation employs around 4,000 people in 150 locations and Chris and his team of Engineers manage the infrastructure that supports them.
He’s supported by the Cloud Collective, a group of three Microsoft partners which work together to help customers gain maximum value from their Microsoft investment.
According to Mark McLean, managing director of Quorum, which is a member of the Cloud Collective; “ It’s been a privilege to work with NRMA, to really understand the challenges that the organisation faces, and then together to blueprint and deliver a digital foundation that meets today’s needs and also evergreens NRMA for the future.”
Working with the Cloud Collective, NRMA has benefited from a Microsoft 365 E5 licence which delivers a slew of additional security and data governance features for the organisation. Microsoft caught up with Chris to find out how.
Microsoft (MS): What were you looking for from Microsoft 365?
Chris Swadling (CS): Our board and senior leaders are continually looking for us to improve our security posture to protect our members, customers and brand. We’ve got a well known and trusted brand. We don’t ever want to compromise the loyalty and trust that comes along with that.
We were primarily looking at ways to improve our security, compliance and data governance posture across the Group. We want to continuously improve security controls without impacting the ability of our people to work and collaborate. Some of the things we’ve prototyped or have implemented include PIM & PAM – Privileged Identity Management and Privileged Access Management; Advanced Threat Protection, End-Point Detection and Response (EDR), Cloud App Security, Azure Information Protection (AIP), and also the big one that everyone wants, Conditional Access and Multi Factor Authentication (MFA).
We are also piloting Azure Sentinel.
MS: How long did this take?
CS: From initial conversations to where we are now is about six months. It never really stops though. We’re continually working to improve and deliver.
We’ve rolled out Teams for better Collaboration – that took us two weeks – and we’ve earmarked using it for Enterprise Voice in the future.
MS: How has this increased security affected users?
CS: The transition has been relatively seamless for the end-users, our staff. The main changes for them are registering for things like MFA, getting used to tagging mail and documents correctly. For the most part, the beauty of all of this stuff is that it’s largely transparent to the end-user. What it does for us as a technology team is that it gives us more visibility into what’s going on, across the organisation and the option to implement controls more rapidly. There’s also a lot of automation/autonomy in these toolsets so that takes some pressure off the team.
MS: Have you been able to measure the impact?
CS: We used Microsoft Secure Score as the baseline and to show improvements as we went along. I believe we compare favourably or are in front of most similar size organisations. We definitely can see that we’ve made improvements but also know there is a long way to go.
MS: How have your digital foundations helped you navigate the pandemic?
CS: Some of it was implemented prior, and a lot of it has been implemented since. Prior to COVID, we only had a small percentage of staff that accessed our systems remotely. Post-COVID, nearly everyone now works remotely. That means a large increase in exposure and there are more vectors for attack. We’ve worked with Cloud Collective and used things like Conditional Access and MFA in front of our VPN technology to help further secure the increasingly distributed team.
We’ve implemented Azure Proxy in front of the platform that’s used by our contact centres. That gives us Conditional Access, MFA and visibility of what’s going on there too.
We have also rolled out Windows 10.
MS: Do you think this new way of working will persist?
CS: Yes. Our new mantra is ‘work is a thing you do, not a place you go’. We’ve been looking at flexible work arrangements and have initiatives in the pipeline to hopefully unlock new labour markets, regional areas for instance, providing opportunities for people would come work with us. We’ve had to bring initiatives forward and the Cloud Collective Team were happy to facilitate, extremely helpful and flexible in the delivery of the project.
The goal for us long term is to move away from reliance on our physical locations and networks and move to an identity-centric model, where our people can do what they need to do from where they want to on any devices they would like. Ensuring we have the appropriate security in place is key to us achieving this.
MS: How fast did you transition to remote working?
CS: I’ve got a team of superstars! The week that COVID hit there were maybe 50 people a day working from home. And then after COVID, nearly everybody was working from home within a week. Mainly this was our contact centres, back-office staff and central functions like Finance and Technology. Our frontline employees are still there helping people every day.
And in another typically laconic note, Chris concludes that; “It’s been both a challenging and interesting past six months. It feels like we’ve done more in the last six than we did in the 12 before that. It’s been exciting.”
This case study was also featured in the media:
CRN article
ARN article
Source: The original interview can be found here
Artificial Intelligence: Skynet the AI poet at Vivid, Sydney!
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Jason Thomas
Breakdown Florida
by: Jason Thomas
Jason Thomas Talks 2019 Florida
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Teutschenthal Saxony-Anhalt, Germany MXGP of Germany FIM Motocross World Championship
We’re once again firing off questions at long-time pro Jason Thomas for some opinions on the fifth round of the Lucas Oil AMA Pro Motocross Championship.
What did you think of the WW Ranch Motocross Park track?
It was definitely “Florida.” The backdrop of a green tree line, the lack of elevation, the soil, the climate; they all reminded me of how every summer day went when I lived there. I think it was great to have another unique addition to the series. Comparing Thunder Valley’s altitude, High Point’s off-camber hard pack, Florida’s rough sand-clay mix, and next weekend’s Southwick sandbox, we have some great variety in the series. Critics in the past have pointed to the Lucas Oil AMA Pro Motocross Championship having the same dirt at most rounds. That has certainly been addressed for 2019.
WW Ranch should be commended for taking such a big step forward from their USGP round, too. I was there and while it was a successful event, I felt that progress was possible and needed. They addressed many of the trouble spots and improved the venue, layout, and soil composition. They did a great job.
Some of these dudes do motos in the heat and humidity of Florida all the time. What makes race day so much harder?
I believe it’s just the additional intensity and adrenaline. As hard as practice motos are, it’s just impossible to replicate the pressure and extra effort that racing demands. There are little differences, too. The morning qualifying sessions aren’t overly taxing but the exertion level for a good qualifying lap is intense. Putting yourself into the red for each of those laps takes a toll. Also, there is a lot of waiting around in the heat before the moto. Staging, opening ceremonies, national anthem, and the sighting lap, all just add time to build heat before the moto. Most practice motos start quickly and guys are rested and cool from hanging out in the garage (or similar). It’s really difficult to not heat up while sitting for several minutes waiting for the race to start. More than anything else, I think that racing is just harder on the body than practice will ever be. The anxiety, nervousness, and adrenaline are ramped way up on race day, making it that much harder.
Riders sported fans, umbrellas, and cold towels—sometimes a combination of the three—throughout the day at WW Ranch Motocross Park on Saturday. Jeff Kardas
Give us some gnarly Florida heat riding stories of your own.
It’s funny because Florida heat is just a daily way of life. I would wake up, have a coffee and head out on my bicycle by 8 a.m. That means I was sweating by 8:01 a.m. and didn’t stop until I got back inside my house at 9 a.m. I would shower and head to the track, arriving by 10. Whether prepping the bike or the track, everyone is sweating already. Moto’s would start by 11 or so and we would finish riding by 3 or 4 p.m. There wasn’t really any time in there where sweating stopped. Even in between motos, while we would be in Chad Reed or Tim Ferry’s air conditioned garage, the internal body temperature was still too hot to stop sweating. So, in other words, sweating commenced at 8 a.m. and really didn’t stop until 5 p.m. Nine-straight hours of sweating. It was not avoidable and anyone who works outside in the south is probably nodding their head about the endless sweating. We didn’t really dwell on it because day in and day out, it was the same.
It’s funny because most of the memories I have about brutally hot races were in the most unlikely of spots. Troy, Ohio, in 1997, 2000 Hangtown, 2003 Millville, 2005 Southwick, and 2007 Freestone, all come to mind when I think about the hottest races of my career. It was expected at Freestone, racing in June in Texas, but the others were unexpected and just as torturous.
What do you think some of these guys felt like on Sunday and Monday?
Most of these guys are so fit that they bounce back quickly. In the hottest of races, I would usually try to find a way to replenish fluids quickly after the second moto (IV is ideal but not available to everyone). That would speed up the rehydration process and made a huge difference in how I felt even Sunday night. By Monday, I didn’t really feel that bad. Soreness and dehydration were still issues but all of those practice days had prepared my body to expect punishment.
My advice to these guys is to take it easy this week. There isn’t much to be gained in going out and hammering motos this week. It takes days to get back to 100 percent and if they don’t rest, they will be tired and dehydrated heading into another tough day at Southwick. I would do everything I could to recover fully this week. I would ride some, sure, but just to stay sharp and maybe work on settings for the Southwick sand. I would try to ride early and avoid the heat and I would do my cardio inside. Recovery is a very underrated factor in racing, especially with back to back difficult events like Florida and Southwick. There is a time for hard work but this week is not it.
What are some key tips for recovery between motos, and also during the week after a gnarly race like this?
The biggest key is getting your body temperature down. Every minute that your core temperature is high is another minute of exertion that will take a toll. Whether it’s a pool to lay in, or an air-conditioned room, do everything you can to get back to normal and stop sweating. I preferred going into the lounge of the semi and have fans blowing on me instead of the pool option. The pool made my skin soft (just like your fingers pruning if you’re in a pool too long) so I would I get blisters more easily during the second moto.
I would also try to wait until the very last minute to get out into the heat again before the second moto. The less I could expose myself to the heat, the less I would ask of my body.
As I mentioned above, it’s all about rest. Forget about trying to improve or get in shape this week. That’s going to put you even further behind. Practice starts, practice a few turns, test a bit but don’t overdo it. Ideally, I would come into Southwick on Friday feeling restless because I didn’t do a lot this coming week. I wouldn’t want the brutal Florida race to have any lingering effects whatsoever. If riders aren’t very mindful this week, they won’t be at full strength this coming Saturday. It’s hard to tell a racer to relax and rest because they are incredibly driven but it truly is the most important thing they can do this week.
Justin Cooper, Florida's 250 Class overall winner, dumps water on himself following a moto. Jeff Kardas
Eli Tomac mentioned struggling with humidity when he was younger, but he has learned to push through it. How much of riding in these conditions in mental?
I would consider it more having experience now than it being mental. He knows what to expect now and probably prepares differently. It’s always a guessing game as to how your body will respond to new experiences and he had to learn how he would feel with a different level of heat and humidity than Colorado offers. Being mentally strong is very important on the toughest of days but that confidence can only be gained from hard work and preparation.
What does this bounce back for Justin Cooper say for his title hopes?
I was impressed. Coming into Saturday, I thought AC92 had a solid chance of another win and possibly putting himself up several points on Justin Cooper along the way. This was his home race and he has been practicing in these same humid conditions. It just seemed like the most likely outcome given his four previous wins in a row, right? Not so fast, my friend. Cooper rebounded from an off day in Pennsylvania to win his first ever overall. Not only that, he did it at the event expected to give Adam an advantage. If he had let Adam build up to a 30+ point lead on Saturday, I think the ball might have started rolling downhill and away from Justin. As we sit now, though, the lead is back down to 18 and the series feels a little differently. I still think this series is Adam’s to lose but Justin rose up in maybe the most pivotal moment in this young series.
Cianciarulo said he might have trained too hard in the heat the week leading up to the race. What are you actually feeling like when you go too far? Do you literally feel bad when you wake up in the morning or is it only notable on the bike?
This is what I think happened to both Cianciarulo and Chase Sexton. They both knew that a win was in the cards for this event and wanted to capitalize. That usually leads to overdoing the preparation when it’s too late to really have a positive effect. It’s a fine line between working hard enough to be ready and working too hard and entering the race tired or still recovering from mid-week training.
Racer X Films: Best Post-Race Show Ever | Florida June 24 - 11:45am
Fly Racing Racer X Podcast: Florida June 24 - 9:05am
Wake-Up Call June 24 - 8:30am
Listen: Main Event Moto Podcast Ep. #124 June 24 - 8:15am
As for how he most likely felt, riders tend to refer to this as feeling “flat.” Ideally, race day is the most energetic day of the week. You’re rested when most of the week you aren’t, and you are excited about getting out there to ride when mid-week you aren’t. If you are still tired from a hard week, you wake up feeling blah and missing that pep in your step. More importantly, when push comes to shove in the hardest part of the moto, your body won’t respond when asked. When Adam saw Cooper and Dylan Ferrandis pulling away early in the second moto, that’s when he needed the extra intensity to pick up the pace. If he was tired and not 100 percent, then he just wouldn’t have it. That’s certainly what it looked like from the outside, too. Adam seemed relegated to holding his position while the Ferrandis/Cooper duo rode off into the sunset. The season is always an ebb and flow of good weekends and bad, so if Adam’s bad weekend is a 5-3 result and third overall, I bet he is okay with it. I would expect a much more rested AC this Saturday.
Fantasy killers? Fantasy winners?
These torture fest races like Florida are brutal for fantasy. It’s impossible to know who will respond well to the heat and who will have issues. For instance, I picked Sexton as my All Star pick and he was only able to ride one moto. Chase is one of the fittest riders in the class and just overheated. That’s horrible for your fantasy team after every sign would have pointed to him having a great day.
Fredrik “Fast Freddie” Noren was a revelation (not for me unfortunately, I didn’t pick him). He was the highest scorer in the 450 Class (recording moto finishes of 9-8) and although I had him on my team for multiple days leading up to the event, I pulled him off two minutes (literally) before the lock-out time. It was a brutal turn of events for me and worse, I replaced him with Jake Masterpool who might have been in an actual pool during the motos because he certainly wasn’t out there riding. That was enough to ruin my Saturday and I was still a little angry Sunday morning, to be honest. Fantasy is incredibly fun and adds a truly unique aspect to the racing throughout the field but it’s one of the cruelest enterprises I have ever encountered, too. It is the definition of an emotional roller coaster.
GP Report: 3 Takeaways From the MXGP of Germany 12:00pm
250 Words: Justin Time 5:00pm
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Photo by Fisher Fotography.
Feminists Shouldn’t Be Opposed to Sexiness
Both “Women Against Feminism” and certain young feminist women often claim that feminism requires you to refuse to be sexy or interested in physical beauty. “F*ck the male gaze,” say the young feminists. “I like it when men compliment me,” say the Women Against Feminism.
Feminism is about equal rights and empowerment. And if we want to be sexy, that’s our right.
Many an Internet meme has insisted that feminists are simply “ugly chicks who can’t get laid.” I think Emma Watson and countless other feminists prove that theorem wrong. Still, there is dissent within the ranks, as indicated when Emma Watson posed scantily clad on the cover of Vanity Fair. Some feminists couldn’t believe that Watson would “degrade herself in that way.” And sadly, many feminists also have a problem with me, for my submittal to the male gaze.
I am an ecdysiast, performance artist, and aerial dancer, all of which involve sexy performance while scantily clad. But I enjoy being sexy for everyone, not just men, and I don’t believe that my activism for reproductive rights or equal pay is diluted just because I’ve taken my clothes off in front of strangers.
I’m especially disappointed to hear shame assigned to those in the sex work and risqué entertainment industries coming from other women. Slut-shaming in everyday life has crystallized into a unilateral workforce distinction of “us vs. them.” “Working women” are legitimate, deserving of equal pay to men and career advancement. “Working girls” are illegitimate, not even women.
Stripping and hooking are considered the “rock bottom” that single women, especially mothers, will reach if they live outside of social norms. Popular media helps these ideas by portraying strippers and prostitutes as women who experienced great personal trauma or socioeconomic distress that placed them in those roles, or by suggesting that their redemption is tied to their “escape” from the industry.
I don’t believe that my activism for reproductive rights or equal pay is diluted just because I’ve taken my clothes off in front of strangers.
Certainly, there are many instances of women being forced into the sex trade or being mistreated by their employers. I’ve seen many a feminist cite those incidents of violence as a reason to shut down all sex work. We call them SWERFs, or “sex-worker-exclusionary radical feminists.” I strongly disagree that sex work is unequivocally bad, and moreover, I believe that we need to destigmatize sex in order to achieve gender equality.
Recently, some charming gentleman left a response on my plea for women to stop slut-shaming themselves. He smugly told me that pimps would agree with my piece. I guess he thought I would be offended, but honestly, I am all for legal sex work in which “pimps” are replaced by supportive managers.
Anthropologist Gayle Rubin has noted that sex and gender are separate and unequal, but part of a system through which people construct the biological aspect of sexuality into either artifacts or venues of human sexual needs. So women, by virtue of being women, are arbitrarily assigned roles related to sex. Their profession provides the “light switch” for others to divide them: sexy for their husband and motherly for their children, or sexy without raising children or supporting a male, which equates to “slut.” Anyone who crosses this boundary makes both SWERFs and non-feminists sweat.
It’s important to note that the exchange of money or goods for sexual interaction or stimulation occurs in a number of situations that are not prostitution or risque entertainment. For example, both men and women may sell images of themselves to sex chat websites, perform in pornographic or risque videos — even for private use — or participate in photo shoots for magazines or websites geared toward this purpose. Where do we draw a line between sexiness and smuttiness? Is it necessary to even draw that line?
I would also note that sex is definitely a factor in “sugar daddy or mama” relationships, and honestly, in the dating sphere. While you might protest that you “don’t date people for their money,” let’s face it, you expect gifts, sexual attention, or both, from people you’re dating, no matter your gender.
Women are expected to confine their open sexuality to socially acceptable situations such as parties. The situations in which they “break free” must be in post-feminist affirmations of independence and equality, or else they are truly “slutty.” Sexy dance must be done in apparently “empowering” situations.
Where do we draw a line between sexiness and smuttiness? Is it necessary to even draw that line?
To both Women against Feminism and SWERFs, burlesque and stripping are “not empowering.” They’re either “degrading” or “submitting to the male gaze.” Either way, these assessments strip agency from women who exchange their sexuality for something else. We’re upholding the patriarchy when we reduce our sexuality to something for male pleasure, but we’re also doing so when we say that women’s sexuality must only be performed within narrow societal confines.
As someone who has found both burlesque and circus immensely empowering in my recovery from sexual abuse, I find it immensely insulting when someone says that I’ve been “duped” or “brainwashed” into some sort of conspiracy of sexiness. It is my body and I will do with it as I please. I want to reclaim my sexuality after it was stolen from me. I am a dancer with strong legs and abs, and I want to celebrate those attributes.
As a feminist, I encourage everyone to express themselves in healthy ways, even if that involves sexiness. I fully support sex workers, camgirls (and camboys!), ecdysiasts, models, and everyone else who uses their sexuality as a means of obtaining something in this world, and I fully believe that you can support equal rights and dismantle the patriarchy while you do it.
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柯肯霓的伊斯蘭研究：穆斯林的先知、古蘭經與耶路撒冷
何偉業
Department of Social Sciences (SSC)
This short article provides an introduction into the contemporary relevance of Bishop Kenneth Cragg’s work on Islamic Studies in relation to the present and future discussions of Christian-Muslim relations. The article firstly introduces the biographical history of Kenneth Cragg. Next, it focuses on Cragg’s major concerns, including debates of the prophetic identity of Muhammad, the revelation of Qur’an and the controversial status of Jerusalem. Cragg’s scholarship and debates provide rich insights and they helpfully serve as points of departure for initiating China’s Christian-Muslim relations, as well as Christian-Muslim relations in the broader Asian context. Through his sympathetic and serious consideration of Islamic interpretations, Cragg has demonstrated that theological or biblical concepts like ‘encountering’, ‘hospitality’, ‘retrieval’ and ‘God in Christ’ are central to his concern of integrating Islamic studies with Christian mission in the Muslim world, and should be explored in future research in China and in the Asian context. Copyright © 2012 中國神學研究院.
中國神學研究院期刊
何偉業(2012)：柯肯霓的伊斯蘭研究：穆斯林的先知、古蘭經與耶路撒冷，《中國神學研究院期刊》，52，頁113-131。
Alt. title: Kenneth Cragg's Islamic studies: Prophet, Qur’an & Jerusalem in the Muslim tradition
published version
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A/Prof Michael Rowland ~ Adjunct Associate Professor
Centre for Tropical Environmental and Sustainability Science
JCU > Research Portfolio > A/Prof Michael Rowland
Mike Rowland was Principal Archaeologist with the Department of Aboriginal and Torres Strait and Multicultural Affairs until September 2012, a position he held since 1981. He is an Editor of Queensland Archaeological Research. He has undertaken archaeological fieldwork in New Zealand, Fiji, New South Wales and Queensland and taught at the University of Auckland, University of New England and University of Queensland. Mike has published over 70 papers on aspects on archaeology with a focus on New Zealand, Fiji and Australia. Mike has a particular interest in the relationship between humans and the environment, especially in small island environments.
Coastal and island archaeology
Cultural heritage management and climate change
Environmental change and human adaptation
Archaeological predictive modelling
Indigenous watercraft use
Cultural heritage management
Repatriation of Indigenous human remains
1981 to 2012 - Principal Archaeologist, Department of Aboriginal and Torres Strait and Multicultural Affairs (Brisbane)
Research Disciplines
Archaeology (2101)
Historical Studies (2103)
Socio-Economic Objectives
Understanding Past Societies (9505)
Ecosystem Assessment and Management (9605)
Flora, Fauna and Biodiversity (9608)
New Zealand Archaeology Association
New Zealand Historic Places Trust
Australian Archaeological Association
ICOMOS Australia
Archaeological and Anthropological Society of Victoria
Australian Rock Art Research Association
Environment Institute of Australia and New Zealand
World Archaeological Congress
Editor, Queensland Archaeological Research
These are the most recent publications associated with this author. To see a detailed profile of all publications stored at JCU, visit ResearchOnline@JCU. Hover over Altmetrics badges to see social impact.
Rowland M (2020) “By savage hands his steps were stayed!”: life and death on the Percy Isles, 1854. Proceedings of the Royal Society of Queensland, 124, pp. 63-79.
Rowland M (2018) 65,000 years of isolation in Aboriginal Australia or continuity and external contacts? An assessment of the evidence with an emphasis on the Queensland coast. Journal of the Anthropological Society of South Australia, 42, pp. 211-240.
Rowland M, Wright S and Baker R (2015) The timing and use of offshore islands in the Great Barrier Reef Marine Province, Queensland. Quaternary International, 385, pp. 154-165, DOI:10.1016/j.quaint.2015.01.025.
Rowland M, Ulm S and Roe M (2014) Approaches to monitoring and managing Indigenous Australian coastal cultural heritage places. Queensland Archaeological Research, 17, pp. 37-48.
Rowland M, Ulm S and Reid J (2014) Compliance with Indigenous cultural heritage legislation in Queensland: perceptions, realities and prospects. Environmental and Planning Law Journal, 31 (5), pp. 329-351.
Rowland M (2013) Geocaching and cultural heritage. Artefact, 36, pp. 3-9.
Rowland M and Ulm S (2012) Key issues in the conservation of the Australian coastal archaeological record: natural and human impacts. Journal of Coastal Conservation, 16 (2), pp. 159-171, DOI:10.1007/s11852-010-0112-5.
Rowland M and Ulm S (2011) Indigenous fish traps and weirs of Queensland. Queensland Archaeological Research, 14, pp. 1-58.
Rowland M (2010) Will the sky fall in? Global warming: an alternative view. Antiquity, 84 (326), pp. 1163-1171.
Rowland M (2008) Saving the past from the future. Historic Environment, 21 (1), pp. 19-29.
Rowland M (2008) Colonization, environment and insularity: prehistoric island use in the Great Barrier Reef Province, Queensland, Australia. In: Comparative Island Archaeologies. BAR International Series. British Archaeological Reports, Oxford, UK, pp. 85-104
Rowland M (2008) Landscape and climate change. In: Handbook of Landscape Archaeology. Left Coast Press, Walnut Creek, CA, USA, pp. 386-395
ResearchOnline@JCU stores 17+ research outputs authored by A/Prof Michael Rowland from 1995 onwards.
Advisory Accreditation: I can be on your Advisory Panel as a Primary or Secondary Advisor.
These Higher Degree Research projects are either current or by students who have completed their studies within the past 5 years at JCU. Linked titles show theses available within ResearchOnline@JCU.
Socio-ecological dynamics in mollusc fisheries: A case study from the Keppel Bay Islands, Great Barrier Reef, Australia (PhD , Secondary Advisor)
The application of ecological models and trophic analyses to archaeological marine fauna assemblages: towards improved understanding of prehistoric marine fisheries and ecosystems in tropical Australia (2016, PhD , Associate Advisor)
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A/Prof Michael Rowland A/Prof Michael Rowland Adjunct Associate Professor College of Arts, Society & Education James Cook University Web
researcher 2019-12-19T18:13:08 +10:00
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FDI in food processing to hit farmers, employment: CAIT
"The government seems to be much lethargic and having least bothered about trading community of the country which is generally considered as strong vote bank of BJP," CAIT said.
March 03, 2016, 16:49 IST
It is a major shift in policy of the government and that too without taking traders into confidence, it added.
NEW DELHI: Opposing the Budget proposal to permit 100 per cent FDI in food processing segment, traders body CAIT today said the move would adversely impact farmers and will result into mass unemployment.
"Allowing foreign investment in any form of retail will have adverse impact on traders, farmers, hawkers, transporters, small industries and will result into mass unemployment," Confederation of All India Traders (CAIT) said in a statement.
Allowing FDI in food sector is nothing but a step in the direction of opening retail sector to FDI much against the declared commitment of not allowing foreign players in the retail sector, it said.
"We strongly oppose this move of the government which will enable the global retailers to control, dominate and monopolise the food sector. The trade fears that today it is the food sector and tomorrow entire retail may be opened on one pretext or the other," it said.
The body urged Prime Minister Narendra Modi to "give us an audience and listen our sufferings" as no priority is given to retail sector, it added.
Further it said the government has not taken cognizance of the report of Indian Council of Agricultural Research, which had stated that food wastage in India is merely 0.8 per cent to 10 per cent.
Any move to allow multinational companies into Indian retail trade will amount to "betrayal of confidence" of the small businesses in India, it said urging the government to issue a white paper on FDI in retail.
budget proposal
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Tag Archives: Ohio
The Watch: Richard Ayoade Needs to be Talked Up
As much as I’m sure some people wanted to see this movie for Vince Vaughn, Ben Stiller, and Jonah Hill, there is one man I wanted to see this movie for in particular. And that man was Richard Ayoade. From over the pond, Richard was brought to us as a gift, and should be treated as one. It’s not that often that a truly talented and gifted British
The true star of the film.
comedian graces us with his presence in an American typical absurdist comedy. It’s not to say that the rest of it wasn’t great, but one person stood out. IT Crowd’s lovable Moss. Let’s get it on.
What makes this movie great for me? The fact that it takes place in a fictitious town in my home state of Ohio. In a typical suburban neighborhood like the one I grew up in, Glenview, Ohio gives a true sense of how mundane and fake people can be in a well off town like this one. Where does a character like Evan Trautwig (Ben Stiller) find excitement from? Creating neighborhood groups and organizations and running. Just as well he would create the local Neighborhood Watch.
Classic slo-mo roll seen with every group of slick bricks.
After a horrendous Predator skinning of his recently hired Latino night guard, Trautwig takes it upon himself to keep the streets safe and find his employee’s murderer. Inspiring justice-like feelings in three men, Trautwig creates a badass group of rollers with great hangout basements. You got Bob Finnerty (Vince Vaughn). He’s the lovable dad and sports fan who wants nothing more than utilize the man cave he created years ago but his wife won’t let him even touch. Franklin (Jonah Hill) is the off the walls juvenile who will do and say anything, at any moment. This movie is where it all started with me. I decided to give Jonah Hill a second chance with all his movies from the past. I love him now.
And last and never least is Richard Ayoade. Everything he’s done for the British comedy circuit on television and otherwise is golden. His
Lookin’ fly with that egg in yo eye, Stiller.
geeky attitude and intelligently witty characters may go unappreciated by the masses, but he hits true to home with me. The I.T. Crowd, his work with The Mighty Boosh, this, and anything else he’s ever made an appearance in. He leaves a memorable place in my heart.
It’s about to get heavy up in this biatch.
The movie got its criticisms for vulgarity and poor plot, but I feel the movie delivered when it had to. The plot wasn’t too complicated so it could focus on the humor, and I got that from the start. Take one part Aliens, and one part small American town dynamic, and you have The Watch. Vince Vaughn almost stole the show (in combination with Jonah Hill) and the vulgarity added to all the angst that someone like me feels in a town where there’s nothing to do and everyone is just too nice. You gotta have the right experiences or this movie doesn’t hold the same amount of weight. Keep that in mind, critics.
Billy Crudup makes the greatest appearance as one of the creepiest neighbors I can think of, and Will Forte is classic
You guys are #1 in my book.
dumbass failure as the cop who didn’t hire Jonah Hill’s character. The movie moves along at the perfect pace but sadly doesn’t give enough funny lines to Richard. Seth Rogen better get off the bong and beer and learn to revise that shizz. But I do hope this movie gives Richard Ayoade other opportunities to shine in American cinema, but he’s just fine where he is in the U.K. So I tip my hat to this film for trying and succeeding to tickle my funny bone. And look forward to a lot of reviews on Jonah Hill films. That dude is gold.
7.8 out of 10.
2 Comments | tags: absurdist comedy, aliens, American cinema, angst, badass, beer, Ben Stiller, Billy Crudup, Bob Finnerty, bongs, British comedian, cops, creepy neighbor, criticisms, dad, Evan Trautwig, experiences, ficticious town, focuses on the humor, Franklin, geeky attitude, Glenview Ohio, home state, intelligently witty, Jonah Hill, justice, juvenile, Latino night guard, man cave, Moss, mundane town, Neighborhood Watch, off the walls, Ohio, perfect pacing, poor plot, Predator, Richard Ayoade, Seth Rogen, skinning, small American town, sports fan, stole the show, The IT Crowd, The Mighty Boosh, The Watch, this movie delivered, tip of the hat, town with nothing to do, typical suburban neighborhood, UK, Vince Vaughn, vulgarity, Will Forte | posted in Movies
Dance Moms: My Only Reality T.V. Obsession
I have to admit here at the very beginning that I, for some strange reason that has sucked me into it, love Dance Moms. I can’t get enough of the fighting, the drama, and all the strange and delirious opinions that Abby Lee holds inside of her enormously inflated head. I’ve watched every episode, enjoyed the dance segments (as small as they are) and analyzed them with my long time dancing girlfriend and before mentioned, Kim. We had caught an episode or two in the past and I had tuned in and out with my mom and sister to see what all the fuss was about.
At first, I hated the crap out of it. I found it to be degrading, conflict infested, and just downright train wreck level television. I thought there could be no way this would ever catch on. Something I still don’t understand is why any of those upset women wouldn’t just stage a walkout and tell everyone not to go to
The wonderful children of Dance Moms:
Nia, Paige, Chloe, Maddie, and Kendall. (There are more)
Abby Lee’s Dance Company. If they all did, she loses business and gains a reputation as a terrible woman. That’s something this show has done for her, but that’s besides the point. She should realize even she’s replaceable. Three girls on the show have shown that so far. But this show has caught on, and its won my heart.
The beast rears its ugly head!
Should I even divulge any of the premise of this show to those of you who unfortunately happen to come across this blog in my post? Let’s see…. Well, the show starts off with the degrading pyramid. Although most of the girls at some point made it to the top, Maddie erroneously held the top for far too long. I don’t want to degrade any of the girls because they are all wonderful little people. But Maddie (the “star” of the show) has to realize that saying arrogant things on camera and crying when you don’t win are things you learn when your mother tells you not to cry in the meanest tone and you always win. Anyways, this whole post is gonna be one long rant.
Next comes a confrontation between one of the moms and Abby Lee or another mom. They train, for 5 days it always seems, and then comes the competition. In between that comes some of the most
The guns, one of Abby’s questionable decisions.
incredulous backstabbing, loud and obnoxious drinking, and one of the most refined, well spoken, and intelligent women I’ve seen on T.V. Nia’s mother, Holly. For that show, Holly is a godsend. She is a rock among the turbulent tides that is the other Dance Moms. And her daughter, although not treated as well as the other girls because she struggles to keep up, still wins when she is given the chance and helps the group win. She wouldn’t be included if she didn’t have the potential and the talent.
All too common in Dance Moms…
Then the competition comes. Maddie (or Chloe) wins and the group comes in 3rd to 1st. And if they don’t, it’s the girls’ faults, not Abby Lee’s. Watch some of these episodes. Marvel and wonder at how she never blames herself, knowing we are all humans and people make mistakes. Every episode, this woman makes mistakes. She is just such a ridiculous woman, I am awestruck at every turn and utter from her croaky voice (what speech problem does this woman have? Or does she just yell all the time because she’s so unhappy with everything?) and the morbidly obese body that at one point performed dances. She has her extreme faults and her struggles with her “nemesis” Cathy from Candy Apples in my home state of Ohio, which is somehow stupidly depicted as farm country. She lives in Canton, a suburban/city town next to Akron. Get your stuff right Lifetime.
There’s a final confrontation, sometimes between moms and who should have won, and then the show ends with the best cliff hangers I’ve ever seen provided from a show. That’s where I’d give the Bravo! Bravo! Encore! Encore! in this. And that’s it. Take that formula and repeat 13 times each season. And then what?!?!? Abby Lee gets put in her place and leaves on hiatus? This is perfect. If I, at any point in this show, could have sat Abby Lee down and shown her every time she was wrong or a Hitler himself in this show, she probably wouldn’t change, but I’d feel better. That woman needs to learn.
And she will never learn. These wonderful children will never know a more enjoyable dance experience. These moms (the few who just don’t understand) will
The best episode of all time. This is all that needs be shown.
never learn. And the cycle will continue. And I will continue to watch. I can’t get enough of this car accident dance television. And it’s not that the show, from a filmmaking standpoint is any good. Who knows if it’s scripted. But, in the end, the show is only good for human’s sick addiction to reality crap television. As much as I’ll fight it, this will be around for a while. God save us all. Overall, this show gets a 3.5 out of 10. May good things always be on these girls, and karma prepare a slap for everyone else. Me as well.
5 Comments | tags: Abby Lee, Abby Lee's Dance Company, Akron, backstabbing, blame thrown around, Candy Apples, Canton, car accident, Cathy, Chloe, cliff hangers, competitions, conflicted, confrontations, cookie cutter plot, croaky voice, crying, Dance Moms, dance segments, dance television, degrading, drama, farm country, fighting, final showdown, group dances, hate it, hiatus, Hitler, Holly, inflated ego, karma, Lifetime, lose business, Maddie, mistakes, morbidly obese, mothers, never ending cycle, never learn, Nia, obnoxious, obsessed, Ohio, pyramid rating, reality TV, replaceable, scripted, sick addiction, star of the show, struggles to keep up, sucked in, talent, terrible woman, train wreck, walkout, wonderful children, young girls | posted in Anime/ T.V.
Super 8: Goonies Meets Close Encounters
Strangely enough about the “golden child” (I’m sarcastically giving him this name.) J.J. Abrams, I’ve only seen two of his films. (Star Trek and now Super 8) And I’ve seen absolutely none of his produced work. I’m a big opponent of Lost. Any show that ends with a dream-like plot in which all the characters are dead… Wow. Nice little steal from The Sixth Sense, you jerk. But I laughed because people were let down. Back to J.J. Star Trek was great, and Abrams only other sci-fi genre film. It was full of action and great dialogue, and, coming from someone who has never watched Star Trek (movies or otherwise) it was a worthwhile watch. True fans didn’t like it, did they? Oh well…
I’m just gonna say, examining J.J. Abrams sci-fi films, I am impressed. Especially with Super 8. This film had a great children’s main cast. Joe Lamb (Joel Courtney) was a fantastic find for this film. Getting into acting through his struggling acting brother, it must suck to be his brother and lacking the opportunity Joel was given. Elle Fanning delivered as the spunky tomboy, Alice Dainard. Gaining a bit of a better reputation than her sister, Dakota, I hope that she goes far with this film. Other notables are Riley Griffiths as that fat boy director, Charles Kaznyk. If only he had stopped using the phrase “mint”, I would’ve liked him better. Ryan Lee was a great element of comic relief as Cary, the pyrotechnics expert. And, surprisingly, the most experienced out of the bunch was the least important of the characters, Zach Mills as Preston. His whiney pansy character fell into the background when the heat turned on.
And what was great about these children was the chemistry between them. Just like in The Goonies, these kids really felt like they were friends before they
A rag tag bunch of kids witness a violent track crash.
started filming. And the back and forth banter between these kids was something to behold. Some good solid character casting. This might be due more to the executive producing of Steven Spielburg, but who really knows? Also, what’s great about this film is that in takes place in Ohio. It needs to be said, being an Ohioan myself, that if you don’t know where to set a story or movie, set it in Ohio. To filmmakers, it appears to be someplace nondescript that anything can take place in. Word.
My big find for this film? Good old Simon from 7th Heaven, David Gallagher. Since then, he’s been doing a bit of work (most notably for me, Riku’s voice actor for the outrageously amazing Kingdom Hearts series) and he was in this movie. Didn’t seem him at first? Look again. David plays Donny, the burnt out, long haired druggie who helps out in the clinch for the rag tag bunch of hoodlums. And I spotted him 6 years later in this film. I’ll put that in the win column for myself.
A love interest. With a zombie film.
Should I talk about the plot of this film? Sure. In this movie, Joe Lamb (Joel Courtney) is the son of a policeman (Kyle Chandler. See? I told you I’d mention him again after that Premonition mention.) and something tragic just recently happened. In a terrible accident at her mother’s factory job, Joe finds himself in a spiral of depression and separation from his father after what happened. Blaming it on a drunken man and his daughter (Elle Fanning), a love between Joe and Alice becomes a Romeo and Juliet situation. Meanwhile, helping Charlie with his zombie film, the friends get together to film a scene one night at a train stop. In a flash, a truck mounts the tracks and head on collides with the train, sending everything into chaos. In the confusion, a specter of an alien is released, causing havoc on the small town outside of Cincinnati. With the help of some locals, this group of filmmakers must find some way to figure out what’s going on and stop the devastation as a strange group of covert army men roll in hard.
For some reason, I wish I had seen this movie in theaters. Watching in on a smaller screen makes me wish I had seen the special effects on a bigger screen. Heck, I was even impressed with the amateur film the group of kids was making. With some big, booming speakers and some darkness to watch it in, my movie watching experience would have multiplied dramatically. But I made do with what I had. I enjoyed the story and characters immensely, but found the sci-fi aspect of the story to lack a bit of originality. The alien was hard to discern and its purpose and history left something to be desired. For me, it was about the kids. With all this in mind, I would give this movie an 8.5 out of 10.
Kyle Chandler does kick some ass in this film.
2 Comments | tags: 7th Heaven, Alice Dainard, alien, banter, Cary, Charles Kaznyk, Charlie, Cincinatti, Close Encounters of the Third Kind, comic relief character, covert army men, Dakota Fanning, David Gallagher, director, Donny, druggie, drunken man, Elle Fanning, fat boy, golden child, good character chemistry, great childrens cast, great dialogue, in theaters quality, JJ Abrams, Joe Lamb, Joel Courtney, Kingdom Hearts, Kyle Chandler, lacks originality, Lost, mint, mother dies, Ohio, Premonition, Preston, pyrotechnics, Riku, Riley Griffiths, Romeo and Juliet like love, Ryan Lee, sci-fi genre films, Simon, solid character casting, spunky tomboy, Star Trek, Steven Spielburg, Super 8, The Goonies, The Sixth Sense, train accident, Zach Mills, zombie film | posted in Movies
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As a top performing high school and collegiate athlete, Terry transitioned his All-American talents to his professional IT career. With no fear of the big stage, he worked his way up the enterprise IT ladder with impact roles at AT&T, Sprint, Level3 Communications, and EDS. After rolling out 10 Tier-4 data centers, working in Level3’s Dedicated NOC, managing complicated IT for mergers and acquisitions, and building out Colorado’s first electronic voter registration system, Terry turned his sights to healthcare IT. Over the past eight years, Terry has made waves in the industry by bringing technology to the forefront, and in 2014 he launched one of Colorado’s fastest growing companies, Rhize Tech. A natural-born leader on and off the field, Terry has assembled a team of industry leaders committed to excellence, fair pricing, exceptional customer service, and providing world-class technology solutions that allow companies to run faster and more efficiently. Rhize Tech is changing the game in Information Technology solutions and consulting.
Byron Radcliff
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Gaby Bonilla
Rhize Tech’s account manager extraordinaire joined the team from distribution giant Tech Data. With over 10 years of IT-specific partner management, Gaby uses her tech prowess to secure optimal solutions for all Rhize Tech clients. Gaby has an eye for industry trends, and her ability to forecast advantageous deals and promotions makes her one of the most sought-after account managers in the business. She specializes in Cisco and VMware product lines. Gaby is also a triathlete, adventure sports enthusiast, world traveler and animal lover.
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Let Your Spirit Guides Speak
A Simple Guide for a Life of Purpose, Abundance, and Joy
Debra Landwehr Engle
"This book is going to be a valuable tool for people who are serious about their spiritual journey. It's one of those topics that people can't get enough of and I want to thank Debra for taking on a huge topic in such a beautiful way." --Echo Bodine, author of My Big Book of Healing and Echoes of the Soul
"If you want to learn ways to connect with your spirit guides, Debra Engle has provided the map to do so. It outlines ways to do so which are accompanied by stories and examples that illustrate these ways. IT is a must have for spiritual seekers!" --Dr. Steven Farmer, international author, spiritual psychotherapist and shamanic healer
�Debra Landwehr Engle, author, inspirational speaker, teacher, and blogger of faith, takes a leap forward with her newest project Let Your Spirit Guides Speak. In her previous book, The Only Little Prayer You Need, she merely hints at the subject of spirit guides. She has now fully embraced the topic and shares boldly about it.
Engle continues to inspire readers, viewers, and live audiences with her gentle nature, considerable kindness, and wisdom, as well as the reassuring passages that we are all being taken care in times of uncertainty. Let Your Spirit Guides Speak will help readers of every level to initiate and cultivate a relationship with their personal spirit guides. Engle�s ministry of using prayer and meditation on a regular basis to request guidance at all times, receive extra support during times of challenge and transition, and to deepen the meaning of our lives and appreciate our connection with Spirit will truly inspire readers.� �Allyson Gracie, Retailing Insight
"Live without your spirit guides and you miss out on an enormous support system that could make your life infinitely easier and more enjoyable."
This is a clear and thoughtful introduction to building relationships with your spirit guides. It shows readers how helpful spirit guides and angels can be in everything from the simplest to the most challenging of life decisions and how easy they are to connect with, too.
Our spirit guides help us to:
Fulfill our purpose
Make decisions that will move us forward faster
Stop sabotaging ourselves as well as judging ourselves and everyone else
Remember that we are more than our job or house or relationship
See ourselves as beautiful and everything in life as a gift
Give ourselves and everybody else a break
Keep growing until the day we leave our bodies behind
Go beyond the life we hoped for and onto the life we never even imagined
And they do all of these things when we're ready and not a nanosecond before. They also often come quietly. As the author states: �If we expect help from Spirit to arrive with the sound of trumpets and blinding light, we'll overlook all the nuanced help that's delivered in small ways every day.�
Debra Landwehr Engle is the author of The Only Little Prayer You Need, Let Your Spirit Guides Speak and Grace from the Garden. She is a longtime teacher of A Course in Miracles, and she mentors writers one-on-one and at international retreats. You can find her at www.debraengle.com. Photo credit: Amy Allen
Hampton Roads Publishing - World
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ReemaFaris.com
the comfort of why
Posts Tagged ‘audiences’
Unnecessary Movie Audience Restrictions
Hieronymus Bosch. A late-Medieval Dutch painter and an artist whose work intrigues my son.
This month the Vancouver International Film Festival Society (VIFF) is screening a movie about curators preparing an upcoming exhibition of Bosch’s work. How interesting! How cultural! How … wait a minute: what do you mean I can’t take my son to see the film?
It turns out that if a film is unclassified, the regulations prohibit the sale of a ticket to anyone under 19. How absurd! Furthermore, when a film is classified and those under 19 are able to attend, the VIFF theatre concession can no longer serve its adult patrons alcohol. How ridiculous!
So, I’ve written a letter to Minister Oakes urging her to cut this red tape and I will mail it this evening.
If you share my point of view on this, please write the Minister, too.
The more she hears from BC voters, the more likely the government will address these anachronistic provisions, which make a mockery of consumer protection.
Honourable Coralee Oakes
Minister of Small Business, Red Tape Reduction
& Responsible for the Liquor Distribution Branch
P.O.Box 9054, STN Prov Govt
Victoria, BC V8W9E2
Dear Minister Oakes,
I had wanted to buy tickets for my family to one of the Vancouver International Film Festival Society (VIFF) screenings of a movie about Hieronymus Bosch, the visionary late-Medieval Dutch painter.
Unfortunately, I’m unable to do so since the movie is unclassified and I cannot buy a ticket for my fifteen year-old son.
My son is an artist and has long been intrigued by Bosch’s work. As his parent, I’m very comfortable in accompanying him to this movie. Its content is cultural, informative, historical, and fascinating. It is in no way a threat to his well-being or his psyche. I think anyone would be hard-pressed to argue that he doesn’t have the maturity necessary to watch this particular film.
In inquiring as to why I was unable to take my son to the movie, I have learned that it is provincial law, not VIFF policy, which demands the classification of films before they can be shown to teenagers. Apparently this law covers only theatrical screenings and DVD releases, but not television nor the internet.
This regulatory policy is based on a logical fallacy that an unclassified film is the same as an unsuitable one. It is a level of red tape that not only hinders operations at VIFF, one of Vancouver’s outstanding cultural institutions, but it also assumes that parents are incapable of determining which movies their teenage children may watch.
The same anachronistic regulations prohibit VIFF from allowing liquor in the theatre on Seymour Street when youth under 19 are present. This seems like an unnecessary duplication of restrictions given that concession staff would be prohibited from serving minors. It also diminishes the experience for older patrons who are denied their full privileges simply because the broader classification of a particular movie expands the audience for that particular screening.
I am writing to ask that you review these particular regulations and amend them at the earliest opportunity. Allow teenagers to attend unclassified movies with their parents’ approval and allow liquor service when a movie audience includes those under 19. That would be an effective red tape reduction and a positive support for small business in the cultural sector.
Thank you Minister Oakes for your consideration of the above. I hope that you will take the measures necessary to introduce a more enlightened approach for screenings of unclassified films in Vancouver, whether at the VIFF theatre or at other locations. Such an approach would facilitate the attendance of teens at film events. It is an approach that will draw in younger audiences, not shut them out and without diminishing the experience of older patrons.
Reema Faris
cc.
Honourable Suzanne Anton, Attorney General & Minister of Justice
Jacqueline Dupuis, Executive Director, VIFF Society
Rob Gialloreto, President & CEO, Consumer Protection BC
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The Different Types Of Loneliness
Story from Mind
There Are Different Types Of Loneliness. Which One Are You Struggling With?
Aoife Clements
Photographed by Poppy Thorpe.
There are three words I'd use to describe 2020. The first is obviously 'lockdown'. Despite only using it once or twice before this year, thanks to the pandemic it's become part of not just mine but everyone’s daily lexicon.
The second word I would choose is 'lonely'.
This year, due to the pandemic, offices have been shut down, people have got used to working out of their homes, families have been kept apart, social gatherings have been cancelled, pubs and restaurants closed, and living situations upended, with one in 10 adult children moving back in with their parents. In a country where 15% of the population already lives alone, this has created a lot of potential for loneliness, with mental health charity Mind warning that the feeling is a "key contributor to poor mental health".
I am no stranger to loneliness. The feeling has ebbed and flowed throughout my life as I've weathered different experiences. The beginning of the pandemic brought my most recent – and difficult – bout.
If you are lonely you may think people do not want to talk to you. This is understandable but research shows that, more often than not, people are usually a lot happier after having a conversation with someone.
The end of 2019 and the beginning of 2020 was marked by illness for me. I spent six months in bed ill due to a flare-up of my chronic illness. Most of this time I was alone and yet it was only when I started to feel better that loneliness began to creep in. I currently live in a different country from most of my friends. I had been unable to visit them due to illness and didn’t have the energy to actively keep in touch. When the pandemic hit I had been off work for many months already and was missing the intellectual and creative stimulation I got from my job. I soon realised that my loneliness was defined by this lack of stimulation and connection that was provided by friends and colleagues. I was, I realised, intellectually lonely – and this was only exacerbated by the coronavirus crisis.
Loneliness is a complicated emotion and just as people's needs differ, so might the type of loneliness they experience. You might be struggling with 'emotional loneliness' or "the absence of a meaningful relationship with a partner or close friend," says Lexy Matthews, communications officer at the Campaign To End Loneliness. "You can experience this type of loneliness even if you are in a romantic relationship or surrounded by people but you feel like you don’t have a meaningful connection with any of them."
There's also a type of loneliness which Lexy refers to as 'social loneliness'. This, she tells me, is "the lack of a wider social network of friends, family, neighbours or colleagues." She says that many people are struggling with social loneliness during the pandemic as they have been unable to get out and interact with their social network as much as they previously would have been able to.
Your loneliness may also be caused by a lack of intimacy: that special physical or emotional bond you share with another person. With couples being kept apart by the pandemic and relationships crumbling under the strain, it's no wonder that this, too, has been exacerbated over the past few months.
Being able to recognise which form of loneliness you are suffering from, and therefore pinpoint what is missing from your life, can help you combat it. According to Lexy, however, it is not uncommon to fail to realise that you are experiencing loneliness in the first place. "It can look and feel different for everybody, as feelings of loneliness are personal and subjective. Technology and social media can make it easy to hide emotions, limit social interactions and avoid real and meaningful conversations, particularly during COVID when we are relying on technology so much to stay in touch." She adds that our aversion to talking about loneliness is preventing us from fully understanding our feelings. "People who are experiencing loneliness often don’t want to admit how they are feeling. This can be a daunting experience, and pride and independence are important for a lot of us, so asking for help can be even harder."
Loneliness is a normal human emotion; it is simply a sign of wanting contact with people. It is not a personal failing.
Fortunately, there are options if you find that the pandemic has left you experiencing any type of loneliness. Lexy recommends taking some time to really think about which of your personal needs is not being met. Are you craving someone's touch? Small talk? Emotional recognition? Then think about who might be able to help alleviate that. "You could start with a text or a call to catch up. Often if you are lonely you think people do not want to talk to you. This is understandable but research shows that, more often than not, people are usually a lot happier after having a conversation with someone."
Lockdown and the subsequent tier system may have curbed in-person meet-ups but it has given birth to a burgeoning world of online interaction. "There has been a boom in virtual book clubs, quizzes, choirs, even dance classes," says Lexy. "Work out where your interests lie and what virtual activities there are in your local area and then hopefully, when we can meet up again face-to-face, you’ll have made some new virtual connections and friendships in your area which you can cement in person."
Lexy stresses that it is useful to find what works for you and what leaves you feeling "fulfilled and connected".
"I think the most important thing is to stay in touch with those around you, in whatever way works for you." She also reminds me that "loneliness is a normal human emotion; it is simply a sign of wanting contact with people. It is not a personal failing and it’s important not to blame yourself for feeling this way."
The third word I would use to describe 2020 is 'hope'. The coronavirus crisis has turned our lives upside down, from how we work and learn to how we exercise and socialise. It has caused a great deal of hardship and heartbreak for many. But while this trauma has been tough to bear, upheaval provides an opportunity for change. The good news is that the pandemic won’t last forever and with the promise of vaccines on the horizon, there may soon be an end in sight.
So, for now, just focus on getting through. If you are experiencing loneliness, have a think about what it is that you're craving and take steps to fulfil that need. Call your family, check in with your friends, remember to think about yourself – we'll get through this together.
If you are struggling with loneliness which is impacting your mental health, please reach out to your GP or contact Mind.
The Different Types Of Loneliness & How To Combat Them
Mind • Lonely Girls’ Club • Health
written by Aoife Clements
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A Photo-Ethnographic Study, India, Madhya Pradesh, Social Documentary Projects
Bateshwar Temples from the eyes of the legendary Archaeologist KK Muhammad: A Photo Essay and FILM
written by Narayan Kaudinya
My earliest memory of meeting KK Muhammad was in his white room, filled with books to the brim, touching the tall old roof of the Red Fort Complex, his newly ancient home. Astounded, I asked him if he would ever finish reading all these books! Smiling, he said, “Narayan an age comes when you don’t keep books to read them, they read me daily instead. I only use them for references”. Somehow I carried this memory for long, and since then had no guilt for keeping as many books myself, thinking either way of someday reading or at least being read by them.
I also remember him today as he came out to be one of the most important person who was behind the archaeological excavations at Ayodhya, that according to him clearly indicated the presence of a temple below the mosque.
Father of one of my filmmaker friend, with whom i was fortunate to work together in the making of this film, that became a tribute, a testimony for his commendable and courageous work in resurrecting a flatland of once ruined temples; those which could have easily missed standing in this age of information. We could have never even heard of this place, these temples, the story behind them or even how hard was it for him who stood up against all odds for and after a decision he took one decisive night.
After months of discussions, conversations on scripting, narrating, the concepts and most importantly presenting, we decided a date and left for Gwalior. Uncle and I were travelling together. Sandeep and Sumit had already reached a day before. We met at Nizamuddin Railway station. It was a night journey and didn’t take longer than a long nap to reach Gwalior city within 8 hours time. It was also comforting in other ways as i had many questions on Indian history and his take on it. And likewise other things apart from work. At one time he asked me to stand to see who is taller, i or him, as we both, are short guys.
The most beautiful part of him was his charismatic presence. He was as curious and kept asking many things about camera, angles and lights. He was seemingly happy to do the film so that more and more people get to know about these temples.
BATESHWAR TEMPLES
Morena was around 44 kilometers from Gwalior railway station. We stopped at the ASI government guest house for a quick shower and breakfast. And taking no extra time, left for Morena, once known as the land of the dacoits. The ravines on either side of Chambal River, known as the Chambal ki ghaati, are well known for having provided shelter for the infamous dacoits.
Bateshwar Temple complex is located in Morena district in Madhya Pradesh. Also known as Batesara or Batesvar, the temple complex is situated on a hilly range about 40 km from Gwalior city near the village of Padavali. The temples are located within the densely forested gorge of the Chambal Valley. And It is one of the most staggering archaeological site to have been created from actually a dream. It is believed that there are almost 200 temples dedicated to Lord Shiva, Vishnu and Shakti within an area of 25 acres.
The name Bateshwar is believed to have been derived from Bhooteshwar, another name for Lord Shiva.
A brief History of Batesvar
The temples are said to have been built around 8th to 10th century AD by the Gurjara – Pratihara dynasty that ruled a large part of northern India from the mid-eighth century to the 11th century. The Pratihars considered themselves as Suryavanshis and are said to be the descendants of Lakshman from the epic Ramayana.
One reference of these temples is found in the reports of Alexander Cummingham. He had visited this region in 1881-82 and mentioned about the temple complex and other temples in the vicinity. “He had mentioned the Bateshwar Temple complex as “a confused assemblage of more than 100 temples large and small, but mostly small, to the southeast of Paravali Padavali”.
At that time, the temple complex was in total ruins and only the main Bhuteshwar Temple and a few other temples were standing. Later, the reference of these temples was seen in the works of Dr. Rahman Ali in 1987 as he worked on the Pratihara art form in India. The Bateshwar Temple complex also finds mention in the monumental research work of R D Trivedi on the Pratihara Temples of Central India. But that is kind of all there is about to these temple complexes that lied in ruins across a slanted hill near Padavali.
As we were coming near to the temples, KK Mohammad went nostalgic and started telling us stories from the very first time when he had arrived here long time ago now, of what he felt the moment he saw this site.
In the opening interview in the film, he says that wherever he has been posted to, he asks for the most difficult site. And for Bateshwar, difficulty was one big Zero. There was actually nothing, it were like many small big stones here and there, to an extent that even the people were not with us. It was then and from there he started with his trysts, threats, complexities and mainly the infamous Chambal ke daku.
THE DAKUS(Dacoits) OF CHAMBAL
On the first evening, most of the crew went back to Gwalior. Sandeep and I decided to stay over in the Temple Complex. As we wanted to film very early in the morning, and also how could I have missed this blessing of sleeping under stars at a place dedicated to adi yogi, Shiva himself. We placed our cots near the bhootnath temple for the night around a campfire and were looked after by the temple guards, of whom we soon learnt in our conversations that went almost all night, that they were the infamous dacoits/daaku of chambal once. Now when no one needs a daaku but a guard, government gave us this work.
“There’s something in the Chambal water that makes people blunt and aggressive,”ex-daaku started speaking, Tall, quiet, squarely built, he moved with gingerly steps, of someone who must have walked miles into the hills and survived being shot in an ambush.
Probably they were also looking to let themselves out after long. He continued saying that the nature of crime has changed in the Chambal today because the people have changed. Few local youths only can endure the rain, mud, scorpions, and walking off a rural outlaw life but the new so called dacoits are urban. They have grown soft. They prey on women and espouse no Robin Hood principles. Unlike the old thugs, who had their codes. It is an old story.
The history of the dacoits in this region goes back to as early as the thirteenth century CE. The dacoits came to limelight only during the British era. However, most of these dacoits were Robin Hood of sorts. They were mostly local outlaws known as Baghis, who were either oppressed by the higher castes, suffered social injustice or were deprived by the law. It was commonly believed that most of these dacoits used to loot the rich people and then distribute the wealth among the poor. Most notorious among these dacoits were Thakur Maan Singh, Putli Bai, Malkhan Singh, Dong-Batri brothers, Sultan Singh, Phoolan Devi and Mohar Singh. Even after Indian independence, the menace of the dacoits continued in the Chambal region.
Gradually, these dacoits either gave up their guns and surrendered or were killed by police encounters. Though organized gang is no longer there in the Chambal region, the gun culture is still prevalent in the region.
“They say a house might not have grains to eat but they will certainly have bullets.”
During 2004, the dacoits had an unwritten control over the Chambal region. Their leader was Nirbhay Singh Gujjar who was said to run a parallel government in about 40 villages. There were as many as 239 criminal charges against him for murder, robbery and kidnapping in his 30 years of dacoity career.
When K K Muhammad first saw Bateshwar in 2004, the temple was in very bad shape. Stones were strewn all over and mixed. Most of the temples were broken down and it seemed like a giant puzzle of stones. Mr. Muhammad decided to decode this jigsaw puzzle and restore the Bateshwar Temple to its former glory.
However, the job was not that easy. The first obstacle in solving the puzzle was the dacoits who had made the temple complex their hideout. So he decided to have a meeting with the dreaded dacoit Nirbhay Singh Gujjar. After several rounds of negotiations, he was able to convince the dacoit that these temples were built by his (Gujjar’s) ancestors. And as a true descendant, he must preserve and protect his heritage and show it to the world. Gujjar was somewhat convinced about the intentions of K K Muhammad and allowed him to start the restoration work. Gujjar asked the archaeologist to restore the front gate and the first 4 temples. The dacoits not only allowed the restoration work to start but also provided protection to the ASI workers and also helped them in the restoration work.
In the hindsight, it can also be said that these temples were preserved because of the presence of the dacoits. No one visited the area and no one carried away stones and the sculptures away, a common thing in most of the ancient monument sites in India.
KK Muhammad started working and with time the temples and the land started showing them the way. The once broken and lost stones and structures started finding their other lost halves. After some months when Nirbhay Singh Gujjar came to visit the site, he was totally surprised to see the place. By then, a gateway and a few temples were restored. He saw the work by the ASI workers, gave a wry smile and went away. It was as if he now gave full permission for the restoration work. Divine works in such ways that, that was the last time he saw the temples and left in peace. Government, which was after him, found him soon and shot him down. Thus ending the terror of dacoits in the region and the restoration work went on with full swing.
But there was another problem waiting, probably bigger and even worse, the Sand Mafia.
Anyways, even though i have told you all this, But it doesn’t amount to nothing when you can hear the man himself. The film took a lot of time and went into many edits due its complex and political nature.
Earlier, the film was named “Man of Temples” but the editing saw many complications not in constructing way but simplifying as much to just convey the required minimum. That took time and slowly the focus transferred to the temples than where it started, to the man who made it possible and still doesn’t want it. Rather he says that, “Bateshwar was like my pilgrimage, lets give it to the man, Mr. KK Muhammad.”
As i remember that time and that shoot, that night with the most beautiful sight, sleeping in the temple was one of the most deep nights personally for me, in a long time staying with the Adi Yogi- near Bhootnath temple.
Filled with stories and peacoks in the morning. The crew arrived late which gave us a resounding time and feeling for the intuition last evening to have stayed with the dacoits past night. To hear so many stories. It became a lot more easier to film them from then onwards, to eat and make friendship that may not just survive but revive the moment those Dacoits will see us again.
The film went on to be screened at many national and international Film Festivals most notably Kerela International Film Festival, MIFF, and IDFA
Awaking in the divinity of Bateshwar temples, with the legendary KK Muhammed from Road to Nara on Vimeo.
This entry was posted in: A Photo-Ethnographic Study, India, Madhya Pradesh, Social Documentary Projects
Tagged with: Archaelogy, archaeological excavations, Ayodhya, Bateshwar, Bateshwar Temples, Chambal Dacoits, Chambal ki Ghaati, Chambal River, Chambal Valley, Dacoits, Film, KK Muhammad, Temples
by Narayan Kaudinya
Hi, I am Narayan Kaudinya. And i welcome you on this journey, the Road to Nara ! I am an Ethnographer and a practicing Indologist. I did my masters in History and further learnt Sanskrit, Yoga and Nerve-therapy. At 24, pushing most academic sounding, office sitting works away, i felt compelled to know and understand the world and my country, Bharat/India. I travelled, and as it happened i took up teaching in Kashmir and further up in the remote villages of Baltistan in the foothills of Karakoram Ranges. For around three years and many states later there came a time when i felt that it was only while teaching i learnt how to laugh, to see, feel, breathe, love and cry -with children, and mostly resource-less parents in the harshest-freezing border conditions. I write, and work as a documentary photographer and Filmmaker, with numerous published, exhibited and some awarded stories. In my travels and life i have let nature lead me, the divine mother, and as a Yogin, my resolve here is to share my experiences and thoughts as honestly, and through them to blossom in everyone the power and possibility in pursuing your breath, that you seek your true nature with courage and curiosity. Here, on this road i will share my spirit, my love for nature, the elements of life that are us. And in doing so, i'll be happy to see you along.
gary j says
Thankyou for sharing this, truly wonderful story, images and film. Hope you are safe and well. Peace and love from Australia.
Narayan Tushar Kaudinya says
Gary, i am very well and safe here. Always makes me delighted to have your name here though it still is in the making 🙂 Your love and peace is well received and happily accepted. Narayan
Amazing work you are doing here. The images are stunning, haunting, enchanting, and jarring (the holy-looking man with gun, and the group of men just standing around casually with guns at the ready). Beautiful documentation.
Lia, see how many beautiful, inspiring words i get to read when you come 🙂
The holy looking men were not holy at all, they were all ex-dacoits who were given governments jobs later to support them.
The film actually beautifully summaries temples ancient history and how they came into being from once being not more than flatlands of ruins.
Aw thank you for the explanation. The film looks beautiful, I took a glimpse but could not understand the language. :)) Thanks again for the reply. :)) 💛
deepsreflections says
Well written.. explaining about the dacoits… I loved the part when gujjar saw the restoration work and smiled … Thanks for acquainting with the work of KK Muhammed..
Deepika, lovely to have you here and for your words. KK Muhammad, certainly has become and played an important part in finding and stating some really needed aspects of Indian History. I am likewise thankful to do my bit. And make, share his work and intent as directly as i can.
richa0112 says
So much to take away from this post. The orientation of stacked books… Morena… for years dacoits was the only thing associated with this belt. Some algorithmic tales narrated here. Glad to follow your journey.
Thank you Richa, always lovely to have your words and read your evolutions, probably like your food.
For me as well, it was an absolute enriching time to spend with KK and to hear small-small details while filming. It also allowed me to respect and see how archaeologists work. it is not just going on field etc but so many aspects to this. And above all political.
Rosaliene Bacchus says
A fascinating story! The tragedy of humankind is that such a sacred place could become overrun by violence.
Hi Rosaliene, i hope you have been healthy, and happily doing things. O yes, i think violence comes closer to us than peace, though is the founding member, violence is what can easily be seen around.
Thank you for coming over and your words. Always a pleasure dear Rosaliene.
Shreya says
What a coincidence this is! Just recently, I had watched a documentary about the Bateshwar Temples in which Mr. KK Muhammed spoke! He said that while he was at the site, he saw a man smoking in the temple premises. Angered, he screamed at him. One of his companions ushered him to the side and told him that he was Nirbhay Singh Gujjar. The one they whose name sent chills.
Mr. KK Muhammed stated that by God’s grace, he managed to say something to the dreaded dacoit that convinced him.
Meeting and speaking with him must have been a terrific experience!
Wonderful, we made a film and this is not there. HAHA. I feel certain of its happening. Also because how his odds turned into his boons. He went all the way to talk to anyone he could to save these temples.
Well, you know he is a friend’s father so that time it was not really valued but completely, we bonded so well, and yes very pleasant memories i have with him.
Moreover, Shreya so happy to know this and that you were aware of his works. Very nice 🙂
Aushi says
Thankyou so much for sharing this with us.. Brilliantly describe 👌👌
.. “learnt in our conversations that went almost all night, that they were the infamous dacoits/daaku of chambal once”.. So daring experience.🤝👏
“They say a house might not have grains to eat but they will certainly have bullets.”… 😢
… “he was able to convince the dacoit that these temples were built by his (Gujjar’s) ancestors”….we need more such people, a huge respect 🙏
… “The dacoits not only allowed the restoration work to start but also provided protection to the ASI workers and also helped them in the restoration work.”… 😱😊😊😊😊..
(NOTHING IS IMPOSSIBLE) Where there is will there is a way… Good intentions finally made their way 🙏🙏😇
Stay safe, stay healthy and happy 😊😊
Aushi, Thank you dear most, so much happiness, i am well and i wish you too are doing things safely with all the precautions.
👍✌️🤝🤝
itsmylife126 says
Interesting. Interesting combo of ancient temples and ex-dacoits.
Central India and more so temples in ancient stories are filled with them.
gifted50 says
Fascinating, the landscape and the people.
Dear Pene, thank you for coming over and words.
Such an insightful post about another one of those hidden treasures that dot our landscape! Thank you for sharing your experience
Thank you for coming and having your words here.
so... says
Such a lovely recounting Narayan. Thoroughly enjoyed it. Hope to visit the complex some day.
Thank you. It will call you someday i am sure.
cathysrealcountrygardencom says
What an astounding story of determination and vision. I watched your wonderful film and despite not understanding the spoken language there was English phrases and the legal letters and some headlines to allow me to understand..Many 🙏
O cathy, i would never have believed you to have watched my architectural film, that to in an alien language. It is the story of grit and tremendous focus. it was important for this thing to happen, to be done. Humbled. Thanks for your words as much Cathy.
luisa zambrotta says
Thank you for sharing this
The story is wonderful, the images are stunning and the film. is really interesting
You must plan a visit here 🙂 Luisa. Thank you for coming over and for your words.
I wish I could visit India again!!!
But your posts let me dream…
Luisa, yes someday again but this pause, this long wait of uncertainty !
🙏🏻💙 🌹
forresting365 says
WOW. Thank You so very much for this, Narayan! I’m blown away. Your explanation of the film was much appreciated and made it easy for me to follow although I don’t speak the language! Those Temples are mindblowingly, astoundingly beautiful!!! I can’t even imagine how it felt sleeping in such a Sacred space. And that they have restored them in such a thorough manner is insanely amazing! To see the rubble…and then the shots of things brought back together again! I don’t even understand how they did it so perfectly. Your cinematography was wonderful!!! Every one of You did an incredible job. I loved the music and editing. The narrator had a very pleasing voice. Congratulations to All of You and to KK Muhammad (and ALL involved!) for going through the obstacles he did to get things done and then to protect the site!!! His quote about his books reading him is one of the best quotes ever! I’ll remember that always!!! Cheers to Your Grand Adventure, and Wonderful Heart, Narayan!!! Thank You again for sharing Your work/life so beautifully!!! 🤗❤️😊
hah ! Forrester.
how beautiful to read this. Feeling awed, really. Yes KK uncle retired a few years ago, lives in Kerela. When Obama had come to India, he was their guide to a few historical sites that they chose to visit.
Story of this temple is truly quiet an inspiration, it was even for me, looking at him, while working with him. You can feel his passion in actions and speech.
Thank you Forester, Cant believe you went through the film without the language. Gratitude and so much love. Nara ! ❤️
It was completely my pleasure, Nara!!! And You are so right….You CAN feel his passion in actions and speech! Even when I didn’t know what he was specifically saying he was fun to watch!!! Cheers, Much Love right back to You and Rock On!!! 💕💕💕
Forrester. So much love.
Friend. Nara !
gabychops says
I am reading your post in the middle of the night but couldn’t stop as it is a fascinating venture into such a distant past. We are having excavation going here in central London right now, next to the cathedral. There are signs that there was a temple there and there are many monks buried there. Finding the past and bringing it to life as you have described is incredibly moving, spiritual experience. Thank you for sharing, Narayan, this glimpse of India’s tumultuous past
Joanna, well Britishers share a part of our history. And see, today i write and we talk because of that only. Its possible 🙂 let me know what do they find finally.
And also because you write so passionately about history and health yourself, must plan an extensive visit to India.
A beautiful day to you Joanna. Nara.
Thank you. As always you are very kind. Of course, I will let you know about the archeological results. I wish I could see India for myself as I have watched many documentaries about this beautiful country.
Some day Joanna. If you would really want to, i believe you will. India is something to experience. Much more than being heard of, or seen from far. And when you are coming, you know whom to write to. 🙂
It would be a dream come true. Thank you. You would be the best guide to follow.
Of course Joanna, to start with lets only pray. World opening back again would be the first dream coming true.
In the meantime, please have a look at my today’s post about human genius
I did and it was lovely Joanna. Monday today, have an inspiring week !
Thank you, and you too.
Yogini says
Wow! I’m speechless reading this beautiful and powerful account. Great pictures too. I’m loving your blog, just looking around for more great stories, inspiration and awe! Thanks so much Narayan 🙂
-Yogini
Dear Yogini, lovely to have you and your words here. And wonderful learn your name being one with Yog 🙂
deeptimpathania says
That was very informative !!! will be following you for more such blogs.
Hi Deepti, lovely to have you here. and your words. I am happy and will be looking forward for more of your wonderful presence here.
Jonathan Caswell says
WOW–VERY IMPRESSIVE WORK!!!!!
Hey, thanks Jonathan for the reblog.
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Laura Jan Shore: 2 poems
on Dec 09, 2020 December 9, 2020
The complexities of love, intimacy and grief: Tricia Dearborn launches Afterglow by Laura Jan Shore
She was on her knees straddling him,
her loose hair, cresting over his chest.
It felt like he’d always crooned
slightly off key in her ear,
as he nuzzled the nape
of her neck, examined the creases
in her palm, rapt
as if she were the pony
he’d begged for each Christmas as a boy.
He ran his calloused thumb
across her lips and she suckled it,
his knuckle salty and a little sweet.
His plush thighs pillowed hers.
She draped the sheets
over their heads, his musk
like forest loam, his hands were at home
steering her hips.
Together, the shattering.
She was unabashed by the animal
sounds she’d made
and when he said, I love you,
his voice rumbling
as if up from an underground cave,
(that phrase her mother dared not utter,
a phrase, she’d needed to hear as a child),
she felt it resound and swell, saturating
her every thirsting cell.
You can’t fix it—
the tsunami in your heart after his death,
…………..the flux and stillness in its wake.
Sun torching the pasture.
…………..The stubborn ground parched to dust.
You can’t fix —
The ice storm in Portland, calved
…………..off glaciers in the Arctic.
Your sister’s cancer. At the healer, her wish—
…………..a peaceful death.
Then brightness
…………..splinters your dark corners.
You know you’re here to be
…………..broken. Nothing to fix.
Not the rift between you
and the sun, not the one
…………..between you and the sea.
Laura Jan Shore teaches poetry in northern NSW. She won the Martha Richardson Poetry Prize (2012) and the FAW John Shaw Nielson Award (2009). Her poetry collections include Breathworks (Dangerously Poetic Press, 2002), Water over Stone (Interactive Press, 2011), Afterglow (Interactive Press, 2020). Her work appears in literary journals across four continents.
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