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The dataset generation failed

Error code:   DatasetGenerationError
Exception:    ArrowInvalid
Message:      JSON parse error: Missing a closing quotation mark in string. in row 71
Traceback:    Traceback (most recent call last):
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 153, in _generate_tables
                  df = pd.read_json(f, dtype_backend="pyarrow")
                File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 815, in read_json
                  return json_reader.read()
                File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1025, in read
                  obj = self._get_object_parser(self.data)
                File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1051, in _get_object_parser
                  obj = FrameParser(json, **kwargs).parse()
                File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1187, in parse
                  self._parse()
                File "/src/services/worker/.venv/lib/python3.9/site-packages/pandas/io/json/_json.py", line 1403, in _parse
                  ujson_loads(json, precise_float=self.precise_float), dtype=None
              ValueError: Trailing data
              
              During handling of the above exception, another exception occurred:
              
              Traceback (most recent call last):
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1997, in _prepare_split_single
                  for _, table in generator:
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 156, in _generate_tables
                  raise e
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/packaged_modules/json/json.py", line 130, in _generate_tables
                  pa_table = paj.read_json(
                File "pyarrow/_json.pyx", line 308, in pyarrow._json.read_json
                File "pyarrow/error.pxi", line 154, in pyarrow.lib.pyarrow_internal_check_status
                File "pyarrow/error.pxi", line 91, in pyarrow.lib.check_status
              pyarrow.lib.ArrowInvalid: JSON parse error: Missing a closing quotation mark in string. in row 71
              
              The above exception was the direct cause of the following exception:
              
              Traceback (most recent call last):
                File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1529, in compute_config_parquet_and_info_response
                  parquet_operations = convert_to_parquet(builder)
                File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1154, in convert_to_parquet
                  builder.download_and_prepare(
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1029, in download_and_prepare
                  self._download_and_prepare(
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1124, in _download_and_prepare
                  self._prepare_split(split_generator, **prepare_split_kwargs)
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1884, in _prepare_split
                  for job_id, done, content in self._prepare_split_single(
                File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 2040, in _prepare_split_single
                  raise DatasetGenerationError("An error occurred while generating the dataset") from e
              datasets.exceptions.DatasetGenerationError: An error occurred while generating the dataset

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pred_label string	pred_label_prob float64	wiki_prob float64	text string	source string
__label__wiki	0.674286	0.674286	Boston Red Sox vs Toronto Blue Jays (Kids run the bases at Fenway) , 09/07/2014, at Fenway Park ... Find Tickets Boston.com Bruins Blog Boston Dirt Dogs Touching all the Bases Boston Sports Blog High School Sports Blog College Sports Blog Tony Massarotti Christopher L. Gasper Obnoxious Boston Fan Fantasy Fools Stats Driven Baseball / Something is always missing By Nick Cafardo Globe Staff / July 7, 2012 The Red Sox just can’t seem to get in synch. One week their hitting disappears. Then they return home and hit, but can’t pitch. You keep thinking this team will eventually put it all together, break away from the pack in the AL East behind the Yankees, and challenge for a wild-card spot. But every time they seem to be making progress, there’s a setback. The starting staff was superb on the recent 2-5 road trip, with only Daisuke Matsuzaka preventing them from having seven quality starts (he lasted one-plus inning and landed on the disabled list). But Friday night Josh Beckett allowed five runs in the first inning. The Sox’ offense responded with five runs in the bottom of the inning, but then you were left with something not witnessed very often this season, a blown lead by the bullpen. The strong suit of this team let them down in a 10-8 loss to the Yankees. When a starting pitcher is as bad as Beckett was and the offense bails him out, the bullpen has to hold the fort. Beckett, who was booed after the first inning, managed to leave the game with a 7-6 lead after five and was in position to earn the win — as ridiculous as that sounds. It’s hard to be overly critical of the bullpen because these moments haven’t occurred very often. But this simply illustrates the Sox’ problem: The thing that wasn’t working, the offense, came around, and the thing that was working, the bullpen, let them down. Matt Albers was fine in the sixth, but Andrew Miller, Vicente Padilla, and Scott Atchison, who have been stalwart setup men, couldn’t do their jobs in the seventh. Miller walked Curtis Granderson and then Alex Rodriguez reached on an infield hit that shortstop Mike Aviles couldn’t backhand. After Miller struck out Robinson Cano, Bobby Valentine opted for Padilla. He allowed a two-run triple to Mark Teixeira, and with two outs an RBI double by Raul Ibanez. Atchison came on and gave up an RBI single by Eric Chavez that gave the Yankees a 10-7 lead. Valentine had no qualms about bringing in Padilla to face the switch-hitting Teixeira, with whom Padilla has had some battles through the years. Valentine reasoned, “I don’t care about the personal stuff because the way Padilla’s been throwing, that’s who I want in there.” And with good reason. Padilla had allowed only one inherited runner out of 19 to score before Teixeira doubled that. That was the best percentage in the majors, so any time Padilla fails, it’s surprising. The Sox still have 15 games left against their biggest rival. They are 8½ games back. At this stage they shouldn’t be worried about first place. They should be worried about winning series and playing consistently in all phases of the game. When the Sox finally get their full complement of players back, they will be the most talented team of the wild-card candidates in their division. You can use the “hanging in there until we get healthy” slogan for so long. And the Sox have done that well. But eventually they have to do more than hang in. The Sox had a chance to gain ground and take over second place while on the West Coast playing a pair of sub-.500 teams, but instead they lost ground and are now battling Toronto for last. They had a chance to beat the Yankees in their home ballpark, but once again failed to take advantage on a night when their bats were due to come around and their ace was on the mound. They have dropped their last five series openers. “You can look at it positively, sure,” Daniel Nava said. “We’ve got what — 77 games left?” It’s actually 79. Then 79 turn into 69, and then 59. And before you know it, you’re not just “hanging in there” anymore. You’re hanging yourself. Yes, this team has suffered an abnormal number of injuries — 23 trips to the disabled list totaling 907 games missed. The latest casualty is Dustin Pedroia, who was hitting only .210 since suffering his first thumb injury May 28 but had showed signs of coming around before reinjuring his thumb. It’s not just his offense that will be missed, it’s also his tremendous defense and leadership on the field. Yes, it’s been tough. It’s been tough to come up with lineups. It’s been tough to have any type of continuity. Valentine said he was not satisfied with the team’s record to this point. He has never lamented the injuries with which he’s been beset in his first season with the Sox, but Valentine knows more than anyone that if the team fails to make the playoffs for a third straight year, he will be the one taking the blame even though he had nothing to do with the first two years. One solace Friday night was that the offense returned somewhat to form. Oh, there was a chance for Adrian Gonzalez to do something big in the eighth inning with runners at first and second with two outs, two runs down, but it just didn’t happen. So Nava may be right. There is time to get this right, to have all aspects of the game come together. And that needs to start in this series. Nick Cafardo can be reached at cafardo@globe.com. Follow him on Twitter @nickcafardo. © Copyright 2012 Globe Newspaper Company. Game pictures Yankees 10, Red Sox 8 Red Sox pitching belted by Yankees Game pictures \| Box score On baseball Red Sox can’t put it all together Teixeira fires back with shot against Padilla Red Sox notebook Dustin Pedroia will get some time off Gasper: Crawford stands by allegation Video Valentine discusses loss Video Gasper's analysis More Red Sox coverage Red Sox Video Globe 10.0 More Red Sox Video	cc/2022-05/en_middle_0076.json.gz/line5
__label__cc	0.712357	0.287643	Pair Sentenced For Fayetteville EZ Mart Robbery 5newsonline.com Zackary Howard, 30, was sentenced to 20 years in the Arkansas Department of Correction, while Kellie Landrio, 44, received 10 years. Both men pleaded guilty to one count of robbery. Howard also pleaded guilty to fleeing and theft of property. Fayetteville police went to the store at 4026 W. Wedington ... Pedestrian struck, dies as cars collide at busy downtown Little Rock intersection NWAOnline Benjamin Krain Arkansas Democrat-Gazette/BENJAMIN KRAIN --2/5/18-- Little Rock police direct traffic away from an accident at 6th and Broadway where a woman was killed after a two vehicle collision at the intesection ended up on the sidewalk where she was standing while waiting to cross the ... Remains found in 1978 finally identified as Michigan couple WNEM Saginaw The remains of a man and woman from Mid-Michigan have been identified nearly 40 years after their murder. Michigan State Police said the human remains were found on June 17, 1978, but 12 miles apart in Missouri and Arkansas. The remains have been positively identified as James Hendricks of ... One dies in Lincoln house fire The fire melted part of the back of Lee's police uniform jacket and singed his hair. Lee was treated at a hospital for smoke inhalation and heat exposure and was released, Morphis said. The Washington County Fire Marshal's Office is investigating, Norton said. No cause of the fire has been determined, ... Police: Little Rock man pulled out machete, threatened to cut woman up ArkansasOnline Mobile - Arkansas Democrat-Gazette Police: Little Rock man pulled out machete, threatened to cut woman up 'into little pieces'. Story by Gavin Lesnick. Tuesday, February 6, 2018. A 40-year-old man is accused of threatening to cut a woman "into little pieces" after she asked him to leave a Little Rock gas station, authorities said. Terrence ... Ualr Map Meredith Mikles Calhoun And Michael Reece Woodruff Ualr Police To Collect Take Back ... Usa Map State and Usa Time Zone Map Ualr Map Third Annual Hoops For Kids Sake Coming March 4 News Our Campus About Us University Of Arkansas At Little Rock When I Get Out Of Cummins Winthrop Rockefeller Collection At The Ualr Center For Arkansas. Arkansas today \| Shelby Mustang Gt 500 Booked Into Arkansas Jail Shelby Mustang Gt 500 Miller, 29, of Moutain Home, was arrested by Arkansas State Police on suspicion of driving with a suspended or revoked license, no proof of liability insurance and not wearing a seat belt, according to the Baxter County Sheriff's Office. He was released from that jail on a $450 ...	cc/2022-05/en_middle_0076.json.gz/line6
__label__wiki	0.587836	0.587836	Home Tags NBN Tag: NBN Businesses are under threat – how to protect your company and your employees Whether they are big or small organisations, owners are oblivious to their responsibilities of implementing preventative measures and countering potential damage to their assets and employees. Australian business owners are turning immersive tech into a (virtual) reality [VIDEO] Anthill Magazine - Mar 14, 2017 Over the next decade, Virtual and Augmented Reality (AR) technologies will create opportunities for small and medium size businesses to interact with their customers in new immersive ways. New year, new way of consuming stuff: – the ‘Access Economy’ is set to... The Access Economy is thriving in Australia because people care more about convenience and lower cost options than they do about owning possessions outright. Sharing or just paying for access doesn't mean missing out. Let’s talk about the NBN: An open letter to the marketing, advertising & media... Anthill Magazine - May 9, 2016 MediaScope's Denise Shrivell is it’s time for Australian marketing, advertising and media to talk about the NBN roll-out strategy and understand its impact A tech start-up is disrupting how we search for homes to buy with a... Anthill Magazine - Oct 20, 2015 With just a team of three, Hutbitat has managed to achieve market coverage for NSW and Victoria in under a year. Now, it looks to Western Australia. Home is where the work is: increasing telework calls for WHS compliance at home Anthill Magazine - Sep 16, 2013 So, are you a teleworker? New info from National Broadband Network says that by 2020, upwards of 12 per cent of the Aussie workforce will... Federal election and NBN conundrum. Can we really expect much? Anthill Magazine - Aug 29, 2013 The rollout will continue, since the government has paid Telstra $11 billion to get access to its network. So we will get an NBN in one form or another. The only question is the technology and the time frame. Serial entrepreneur helps QLD small businesses embrace the digital era Hadley Jones - Apr 6, 2012 Queensland businesses that are not online have been given an opportunity to leap into digital era, with a state-wide program to help train businesses. Skills Queensland is running a state-wide program called "Get Up to Speed" for the next 12 months that is designed to help businesses embrace online. How to game your ISP when the NBN rolls into town Natalie Chandler - Nov 22, 2011 The super-speedy new National Broadband Network (NBN) is sloooowly inching closer. But it’s not just digital junkies who’ll benefit from the multitude of megabits; their pushers can also expect a new lease on life. Internet Service Providers (ISP), that is. All clear for the NBN, new anti-siphoning laws and more Christopher Mote - Dec 3, 2010 Leon and Garry talk about Telstra’s shares soaring with the Government getting the NBN legislation through parliament. What’s next, and how is the business model shaping up? Plus, a look at the new anti-siphoning laws and why they provide wins for both free-to-air TV and pay TV. Will the NBN simply involve one monopoly supplanting another? Contributor - Dec 1, 2010 The establishment of an NBN, as currently proposed, creates a legitimate concern: will Australia supplant one great big monopoly with another great big monopoly? If the controlling body of the NBN displays monopolistic tendencies in pricing and management (which it may have to do given the proposed level of investment), then what benefits will we really be creating? With the NBN, deregulation begins now Contributor - Nov 18, 2010 The National Broadband Network has been heralded as a groundbreaking advance but has also raised concerns that it will create just another monopoly. In this first of two parts, Tony Simmons argues that the NBN can at last bring to Australian telecommunications a genuine opportunity for competition and growth... provided we learn from past. Malcolm Turnbull explains the Opposition’s case against the NBN Christopher Mote - Oct 20, 2010 In this week's Talking Business interview, Leon and Garry speak with Liberal MP Malcolm Turnbull, former Opposition leader and current shadow spokesman for telecommunications and broadband. He criticises the Government’s plan for the National Broadband Network as too expensive and lacking in any cost-benefit analysis. Calling the NBN an effective monopoly that will make any competition impossible, Mr. Turnbull endorses incremental improvements to the existing network as a fiscally responsible policy. Telstra hurrying Government to deliver on NBN. ‘Get it finalised by Christmas!’ Anthill Magazine - Oct 6, 2010 Leon and Garry talk about the difficulty getting the legislation for the NBN through Parliament. But the Government needs to hurry as Telstra wants to have the NBN finalised by Christmas. Telstra has also released its latest renewal plan. Meanwhile, its share price has fallen to an all-time low. Gillard Government holds on: what’s the agenda for business? Christopher Mote - Sep 21, 2010 Garry and Leon talk about the new Labor government just scraping back into office. Download the podcast to find out how it will affect the outcomes of Australia’s credit rating, the mining tax, the NBN and more, plus all the latest in business news. Five ways to manage your time by managing yourself, with Helen... Anthill Magazine - Nov 6, 2015 Finding the time to tackle everything is one of the greatest challenges faced by business owners. To help time-starved business owners work smarter and not harder, we spoke with Helen Ebdon. The director of Affirming Business and Executive Coaching, she’s a serial entrepreneur who started her first business at age 25. She’s built and run direct marketing and communications businesses and she’s also the creator of the Take 15 Program for business effectiveness. Inbound Marketing Reloaded with James Tuckerman [FREE REPORT] Learn how to use Instagram as a business tool [FREE INFOGRAPHIC] Five essential things to get right if you want to raise... Strategic Alliances with Simone Novello [FREE INFOGRAPHIC] This is either the best, or worst mission statement for a startup you’ll ever see [VIDEO] Jen Storey - Feb 28, 2013 Online Marketing By Design seminar, Sydney [video] Anthill Magazine - Feb 12, 2010 B2B marketing and social media: how to get valuable insights into your market [VIDEO] Whatever you do, don’t make a video about your business like this one [VIDEO] Jen Storey - Mar 26, 2014 WANTED: Big thinking entrepreneur for documentary film. Must travel. Anthill Magazine - Aug 9, 2010 How to expand into New Markets with Elsita Meyer-Brandt [CHEAT SHEET] Most organisations begin with aspirations to start local, then grow global. But, in reality, very few ever take the big leap into new markets. In this Cheat Sheet, Elsita Meyer-Brandt, Head of Market Expansion and International Marketing for Eventbrite, shares five rules to help organisations, just like yours, expand into new markets. Seven essential steps to a successful podcast with Loren Bartley [Cheat... How did Sean Clark build a $300 million turnover company from... The Alchemy of Negotiation with Matt Lohmeyer [FREE REPORT]	cc/2022-05/en_middle_0076.json.gz/line14
__label__cc	0.704754	0.295246	Locker, Arthur x Leveson Francis Vernon-Harcourt ATH, Waterways and Water Transport in Different Countries / Jeans, J. Stephen., 486 - 487, Volume 1890, Oct 11, 1890, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Sewage Disposal Works / Crimp, W. Santo., 741 - 741, Volume 1890, Nov 29, 1890, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, The Chemistry of Iron and Steel Making / Williams, W. Matthieu., 801 - 802, Volume 1891, Jun 20, 1891, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Wire / Smith, J. Bucknell., 323 - 324, Volume 1891, Sep 5, 1891, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, The Design of Structures / Anglin, S., 456 - 456, Volume 1891, Oct 3, 1891, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, The Iron and Steel Maker / Jjoynson, F. (ED), 640 - 640, Volume 1893, May 20, 1893, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, The Romance of Engineering., 195 - 196, Volume 1893, Aug 5, 1893, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Toothed Gearing., 230 - 231, Volume 1893, Aug 12, 1893, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Civil Engineering Series -Midal Rivers., 648 - 649, Volume 1894, May 19, 1894, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, The Tower Bridge., 164 - 164, Volume 1894, Aug 4, 1894, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, British Locomotives., 259 - 260, Volume 1894, Aug 25, 1894, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Our Railways., 424 - 425, Volume 1894, Sep 29, 1894, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, The Steam-Engine War / Burn, R. Scott (ED)., 411 - 411, Volume 1895, Mar 30, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Elementary Lessons in Steam Machinery and the Marche Steam Engine., 411 - 411, Volume 1895, Mar 30, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Gas, Oil, and Air Engines., 445 - 446, Volume 1895, Apr 6, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, A Text Book of Meclanical Engineering., 495 - 496, Volume 1895, Oct 12, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, the Steam Engine and other Heat Engines., 495 - 497, Volume 1895, Oct 12, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Steam and the Marine Steam Engine., 495 - 497, Volume 1895, Oct 12, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Notes on Docks and Dock Construction., 495 - 497, Volume 1895, Oct 12, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19) ATH, Principles and Practice of Harbour Construction., 611 - 612, Volume 1895, Nov 2, 1895, Leveson Francis Vernon-Harcourt, From 'Athenaeum: Index of Reviews and Reviewers 1872-1900', Ghent University Library. [review] (12/19)	cc/2022-05/en_middle_0076.json.gz/line23
__label__cc	0.647179	0.352821	Use of Micro RNAs to Screen for Colon Cancer Farid E Ahmed* and Nancy C Ahmed Department of Radiation Oncology, GEM Tox Labs, Greenville, NC 27834, USA *Correspondance to: Farid E Ahmed Colon cancer (CC) screening is important for diagnosing early stage for malignancy and therefore potentially reduces mortality from this disease because the cancer could be cured at the early disease stage. Early detection is needed if accurate and cost effective diagnostic methods are available. Mortality from colon cancer malignancy is theoretically preventable through screening. The Current screening method, the immunological fecal occult blood test, FOBTi, lacks sensitivity and requires dietary restriction, which impedes compliance. Moreover colonoscopy is invasive and costly, which decreases compliance, and in certain cases could lead to mortality. Compared to the FOBT test, a noninvasive sensitive screen that does not require dietary restriction would be more convenient. Colonoscopy screening is recommended for colorectal cancer (CRC). Although it is a reliable screening method, colonoscopy is an invasive test, often accompanied by abdominal pain, has potential complications and has high cost, which has hampered its application worldwide. A screening approach that uses the relatively stable and non degradable micro RNA molecules when extracted from either the noninvasive human stool, or the semi-invasive blood samples by available commercial kits and manipulated thereafter, would be more preferable than a transcriptomic messenger (m) RNA-, a mutation DNA-, an epigenetic- or a proteomic-based test. That approach utilizes reverse transcriptase (RT), followed by a modified quantitative real-time polymerase chain reaction (qPCR). To compensate for exosomal miRNAs that would not be measured, a parallel test could be performed on stool or plasma's total RNAs, and corrections for exsosomal loss are made to obtain accurate results. Ultimately, a chip would be developed to facilitate diagnosis, as has been carried out for the quantification of genetically modified organisms (GMOs) in foods. The gold standard to which the miRNA test is compared to is colonoscopy. If laboratory performance criteria are met, a miRNA test in human stool or blood samples based on high through put automated technologies and quantitative expression measurements currently employed in the diagnostic clinical laboratory, would eventually be advanced to the clinical setting, making a noticeable impact on the prevention of colon cancer. Bioinformatics; Diagnosis; Histopathology; Microarrays; QC; RNA; RT-Qpcr; Statistics Ahmed FE, Ahmed NC. Use of Micro RNAs to Screen for Colon Cancer. Clin Surg. 2017; 2: 1565.	cc/2022-05/en_middle_0076.json.gz/line25
__label__cc	0.57908	0.42092	Università degli Studi di Trento Unitn-eprints.PhD Unitn-Eprints Research Items where Doctoral School is "Information and Communication Technology" and Year is 2010 Group by: Creators \| No Grouping Jump to: A \| B \| C \| D \| F \| H \| K \| M \| N \| O \| P \| R \| S \| T \| V \| W \| Z Autayeu, Aliaksandr (2010) Descriptive Phrases: Understanding Natural Language Metadata. PhD thesis, University of Trento. Ali, Raian (2010) Modeling and Reasoning about Contextual Requirements: Goal-based Framework. PhD thesis, University of Trento. Department of Information Engineering and Computer Science. Ageev, Anton (2010) Time Synchronization and Energy Efficiency in Wireless Sensor Networks. PhD thesis, University of Trento. Adami, Andrea (2010) MEMS Piezoresistive Micro-Cantilever Arrays for Sensing Applications. PhD thesis, University of Trento. Biazzini, Marco (2010) GOssiping Optimization Framework (GOOF): A decentralized P2P architecture for function optimization. PhD thesis, University of Trento. Cilia, Elisa (2010) Statistical and Relational Learning for Understanding Enzyme Function. PhD thesis, University of Trento. Campigotto, Paolo (2010) A Reactive Search Optimization approach to interactive decision making. PhD thesis, University of Trento. Dalponte, Michele (2010) Analysis of forest areas by advanced remote sensing systems based on hyperspectral and LIDAR data. PhD thesis, University of Trento. Dinarelli, Marco (2010) Spoken Language Understanding: from Spoken Utterances to Semantic Structures. PhD thesis, University of Trento. Dematté, Lorenzo (2010) Scaling up Systems Biology: Model Construction, Simulation and Visualization. PhD thesis, University of Trento, CoSBi. Forlin, Michele (2010) Knowledge discovery for stochastic models of biological systems. PhD thesis, University of Trento. Farazi, Mohammad Shahjahan Feroz (2010) Faceted Lightweight Ontologies: a Formalization and some Experiments. PhD thesis, University of Trento. Franzén, Anders (2010) Efficient Solving of the Satisfiability Modulo Bit-Vectors Problem and Some Extensions to SMT. PhD thesis, University of Trento. Frankova, Ganna (2010) Engineering Business Processes with Service Level Agreements. PhD thesis, Johann Bernoulli Institute of the Rijksuniversiteit Groningen, the Netherlands. Hossain, Quazi Delwar (2010) Design and Characterization of a Current Assisted Photo Mixing Demodulator for Tof Based 3d Cmos Image Sensor. PhD thesis, University of Trento. Krapivin, Mikalai (2010) A Semi-supervised Approach for Improving Search, Navigation and Data Quality in Autonomous Digital Libraries. PhD thesis, University of Trento. Kharkevich, Uladzimir (2010) Concept Search: Semantics Enabled Information Retrieval. PhD thesis, University of Trento. Morshed, Ahsan (2010) Aligning Controlled vocabularies for enabling semantic matching in a distributed knowledge management system. PhD thesis, University of Trento. Manica, Luca (2010) Innovative strategies for the synthesis of Time-modulated antenna systems. PhD thesis, University of Trento. Mascia, Franco (2010) Analysis of Reactive Search Optimisation Techniques for the Maximum Clique Problem and Applications. PhD thesis, University of Trento. Nesta, Francesco (2010) Techniques for robust source separation and localization in adverse environments: Issues and performance of a new framework of emerging techniques for frequency-domain convolutive blind/semi-blind separation and localization of acoustic sources. PhD thesis, University of Trento. Odorizzi, Lara (2010) Lab-on-cell and cantilever-based sensors for gene analysis. PhD thesis, University of Trento. Palmisano, Alida (2010) Modelling and Inference Strategies for Biological Systems. PhD thesis, University of Trento. Pighin, Daniele (2010) Greedy Feature Selection in Tree Kernel Spaces. PhD thesis, Università di Trento, Fondazione Bruno Kessler. Persello, Claudio (2010) Advanced Techniques for the Classification of Very High Resolution and Hyperspectral Remote Sensing Images. PhD thesis, University of Trento. Paoli, Silvano (2010) A high performance computational environment for UHTS studies. PhD thesis, University of Trento. Ress, Cristina (2010) Micro electrochemical sensors and PCR systems: cellular and molecular tools for wine yeast analysis. PhD thesis, University of Trento. Repchankova, Alena (2010) Anti-Stiction And Self-Recovery Active Mechanisms For High Reliability RF-MEMS Switches. PhD thesis, University of Trento. Repich, Marina (2010) Development of a simulation environment for the analysis and the optimal design of fluorescence detectors based on single photon avalanche diodes. PhD thesis, University of Trento, Fondazione Bruno Kessler. Romanel, Alessandro (2010) Dynamic Biological Modelling: a language-based approach. PhD thesis, University of Trento. Sameh, Abdel-Naby (2010) A Nomadicity-driven Negotiation Protocol, Tactics and Strategies for Interacting Software Agents. PhD thesis, University of Trento. Schivo, Stefano (2010) Statistical Model Checking of Web Services. PhD thesis, University of Trento. Siahaan, Ida Sri Rejeki (2010) Security-by-Contract using Automata Modulo Theory. PhD thesis, University of Trento. Siena, Alberto (2010) Engineering Law-Compliant Requirements: the Nomos Framework. PhD thesis, University of Trento. Ture Savadkoohi, Bita (2010) Analysis of 3D scanning data for optimal custom footwear manufacture. PhD thesis, University of Trento. Trecarichi, Gaia (2010) Towards the Application of Interaction-oriented Frameworks to Information Sharing in Emergency Contexts. PhD thesis, University of Trento. Ture Savadkoohi, Parisa (2010) Study of the electromechanic aspects of RF MEM devices with particular emphasis on the dynamic behavior for the case of RF MEM switches and tuneable capacitors. PhD thesis, University of Trento, Fondazione Bruno Kessler (FBK). Tebaldi, Toma (2010) Computational and experimental detection of uncoupling between transcriptome and translatome changes of gene expression. PhD thesis, University of Trento. Viani, Federico (2010) SVM-based Strategies as applied to Electromagnetics. PhD thesis, University of Trento. Weldemariam, Komminist Sisai (2010) Using Formal Methods for Building more Reliable and Secure e-voting Systems. PhD thesis, University of Trento, Center for Information Technology (FBK-Irst). Zámborszky, Judit (2010) Compositional Modeling of Biological Systems. PhD thesis, University of Trento. Unitn-eprints PhD supports Open Archives Protocol for Metadata Harvesting OAI 2.0 with a base URL of http://eprints-phd.biblio.unitn.it/cgi/oai2	cc/2022-05/en_middle_0076.json.gz/line28
__label__wiki	0.76062	0.76062	Optimal currency areas: why does the exchange rate regime matter? (with an application to UK membership in EMU) Buiter, Willem H. (2000) Optimal currency areas: why does the exchange rate regime matter? (with an application to UK membership in EMU). CEPDP (462). Centre for Economic Performance, London School of Economics and Political Science, London, UK. ISBN 0753013886 Microeconomic efficiency and market transparency argue in favour of UK membership in EMU and for Scotland''s membership in the UK monetary union and also in EMU. UK seigniorage (government revenues from money issuance) would be boosted by EMU membership. Lender of last resort arrangements would not be substantially affected by UK membership in EMU. The UK is too small and too open to be an optimal currency area. The same point applies even more emphatically to Scotland. The ''one-size-fits-all'', ''asymmetric shocks'' and ''cyclical divergence'' objections to UK membership are based on the misapprehension that independent national monetary policy, and the associated nominal exchange rate flexibility, can be used effectively to offset or even neutralise asymmetric shocks. This ''fine tuning delusion'' is compounded by a failure to understand that, under a high degree of international financial integration, market-determined exchange rates are primarily a source of shocks and instability. Instead, opponents of UK membership in EMU view exchange rate flexibility as an effective buffer for adjusting to asymmetric shocks originating elsewhere. I know of no evidence that supports such an optimistic reading of what exchange rate flexibility can deliver under conditions of very high international financial capital mobility. The economic arguments for immediate UK membership in EMU, at an appropriate entry rate, are overwhelming. Monetary union raises important constitutional and political issues. It involves a further surrender of national sovereignty to a supranational institution, the ECB/ESCB. It is essential that this transfer of national sovereignty be perceived as legitimate by those affected by it. In addition, the citizens of the UK have become accustomed to a high standard of openness and accountability of their central bank since it gained operational independence in 1997. The ECB/ESCB must be held to the same high standard, and, while there are grounds for optimism, there still is some way to go there. Monograph (Discussion Paper) http://cep.lse.ac.uk © 2000 W. H. Buiter European Institute Centre for Economic Performance	cc/2022-05/en_middle_0076.json.gz/line29
__label__cc	0.707763	0.292237	Web Letters in Response to ‘Housing the Rich’ EW readers respond to Paul Conte's Viewpoint on HB 2001 Letters by EW StaffPosted on 08/26/2021 REZONING WILL HELP THE WORKING CLASS Yes, Eugene does have a rental affordable housing crisis. If you pay more than 30 percent of your monthly income for rent you are housing-cost burdened — if you can even find a place to live in the first place. Look at working-class incomes and current rents, and do the math. Eugene, like just about every other city in the U.S., has exclusionary zoning, meaning you can’t build apartments in most of the city. It’s basically a class war between middle-class homeowners, who want to keep apartments out of their neighborhoods, and working-class renters, who are half of Eugene residents. The law of supply and demand has not been repealed. A drastic shortage of apartments has allowed greedy landlords to jack up rents as much as the traffic will bear. The result is that a lot of working-class people can no longer afford to live in Eugene. Oregon’s HB 2001 requires Eugene to upzone single family home areas by June 30, 2022. We don’t have a choice. People who don’t accept this are wasting our time. EW could perform a much needed service by actually covering the issue, instead of printing NIMBY crap from the likes of Paul Conte. To quote the fictional New England police chief Jesse Stone, “Information is out there, all you have to do is let it in.” Lynn Porter BUT CAPITALISM WORKS SO WELL ELSEWHERE You’re kidding, right? The city of Eugene’s answer to housing affordability and racial diversity in housing is to let developers do as they wish in a diverse, healthy residential neighborhood? Haven’t we seen this act before? I suppose the answer for global climate change is more free-market industrial policy! Matt Purvis UPZONING WON’T HELP AFFORDABILITY Re “Housing the Rich,” (EW, 8/12): Willful ignorance on the part of Eugene planners and planning commission it certainly is. Claiming this upzoning would improve housing affordability is ludicrous. Developers aren’t going to build low income housing without a subsidy. They’re going to build homes that only the middle class or higher can afford. That’s where the money is. That’s what developers do, build to make money. They’re not in business to help the needy. We’ve heard “trickle down” before, and it doesn’t work. Trickle down new housing is not going to reduce housing costs for low income buyers. These proposed changes by the Eugene planners and planning commission will only benefit developers and help further erode affordable neighborhoods. Steve Pringle EUGENE PLANNERS NEED TO LISTEN In reaction to the “Housing For the Rich” Viewpoint by Paul Conte in the Aug. 12 edition of Eugene Weekly, I would like to ask Eugene planners and planning commissioners whether they are engaged with Eugene’s citizens regarding their official duties, and whether Eugene’s citizens feel engaged with them. “Engagement” implies a two-way interaction among parties who express themselves and attempt to understand one another’s opinions, and the data, facts and reasoning behind them. This process does not generally lead to a single shared position, since there can never be universal consensus in a diverse community. The point of engagement, then, cannot be to achieve universal consensus on issues, but to satisfy community members that they have truly been heard and that they have truly heard the opinions and reasoning of others. Eugene’s citizens deserve and expect no less than engagement by city employees regarding decisions that affect their lives in important ways. Eugene’s planners and commissioners must engage with us regarding the zoning decisions currently being considered. Charles Snyder DON’T LET THEM PAVE PARADISE The benefits of trees to the landscape of our city are numerous: cleaner air, lower city temperatures, less energy used to cool our homes, wildlife habitat and beauty. However, the city staff is considering a code change that would eliminate current tree protections on residential lots. This would allow a residence to consume up to 70 percent of a lot (up from 50 percent). This is one of many changes being proposed in the name of “affordable housing.” Imagine another summer like the one we’ve experienced this year, but add another 2 to 11 degrees, the reported difference by the USDA in a study of the impact of the urban tree canopy. There is an abundance of evidence to support increasing and protecting the urban tree canopy. Where is the data to support the city staff’s proposal? It does not have to be a choice: We can have intelligent, data-driven changes and affordable housing. Chances are, these changes to the city code are news to you. Stay informed and let the city staff know you want the residents of this city to be involved. Sign up for land use updates and submit comments to the Eugene Mayor, City Council and City Manager (MayorCouncilandCityManager@Eugene-or.gov) ahead of the Sept. 15 work session. Rachael Latimer THE ANSWER IS TO BUILD MORE HOUSING Contrary to Paul Conte’s assertions (“Housing the Rich,” EW 8/12), building more housing — and doing so in environmentally friendly dense communities with access to mass transit — is a necessary component to solve entrenched housing affordability challenges. Indeed, recent research from New York City, San Francisco and Tokyo all highlight the connection between density and lower rents/sales prices, and long-standing research from respected housing economists has established a clear link between restrictive zoning and affordability challenges. But we can’t just “build, baby, build.” We also need broader support for housing vouchers (with the ability to nudge families to neighborhoods of opportunity), affordable housing tax credits and incentives to eliminate restrictive housing regulations that increase the cost of building homes for Americans — each of which appears in the president’s housing plan. My message to my fellow Eugeneans: Welcome more neighbors to your communities by supporting reforms that promote new growth — particularly along mass transit — and fight like heck to demand that local, state and federal government provide permanent sources of funding to address the needs of low-income Americans in Lane County and across the country. Andrew Kalloch HIGH END RENTALS HELP SPECIAL INTERESTS Allowing investors to develop high-end rentals to improve housing affordability amounts to promoting our very own local Big Lie. It will have a negative impact on housing affordability for low income households. On top of that, keeping unsuspecting property owners in Special Area Zones unaware of what’s going on is a calculated manipulation of public process by the Planning Department. It amounts to exploiting selective special interests’ opinions. Erika Seiferling CITY PLANNERS WILL INCREASE HOMELESSNESS I wholeheartedly agree with Paul Conte’s Viewpoint (Housing for the Rich,” EW 8/12). Gentrification displaces many households, and the latest efforts by city planning staff only worsens the problem. We need more housing affordability, not more high-rental properties in Eugene. Duncan Rhodes HOMELESSNESS IS ABOUT WEALTH DISPARITY It’s been said of Americans that they will generally come up with the solution to a problem — after having tried everything else first. I feel that way about the many games being played around the shortage of affordable housing. Paul Conte’s excellent “Housing the Rich” (EW 8/12) is a terrific attempt to cut through the gamesmanship and focus on the realities. The real solution is in Conte’s quote from a Black advocacy group: “[F]air housing will only be fulfilled if displacement prevention and preservation/production of deeply affordable housing are uppermost priorities.” The opposite result is illustrated in Conte’s example of a new quadplex at 94 and 96 W. 15th Avenue, where the developer demolished two former lower-cost rentals, displacing the occupants, and each apartment now rents for $3,195 a month. The shortage of affordable housing results from the maldistribution of wealth and income, the shortage of living wage jobs, the failure of governments to tax wealthy individual and business interests fairly, and other inequities currently shredding the social fabric. Resulting homelessness won’t be fixed by allowing speculators to build and sell or rent housing on lots now occupied by affordable homes, thus destroying the livability of neighborhoods. Instead, we need to fix those inequities and use the resulting funds to build public housing — lots of it, on the model of the housing built by St. Vinnie’s and other affordable housing projects in Eugene. And meanwhile, keep the affordable housing we already have. For more info: Housing-Facts.org. PLANNING TO HELP THE RICH City planners are proposing extreme changes to the Eugene Code in support of HB 2001, state middle-housing legislation. The proposed changes go far beyond the intent of HB 2001 and would facilitate the construction of market rate rentals, not affordable housing. These changes will potentially alter the character of single-family neighborhoods. HB 2001 defines middle housing as duplexes, triplexes, fourplexes, row houses and cottage clusters. The law requires that cities allow duplexes on all single-family lots, and the other housing types in all residential neighborhoods. This project has been active for over a year with little public engagement. The general public has had no chance to understand these changes or provide comments. The staff’s proposal would reduce duplex lot sizes from 8,000 square feet to as little as 1,688 square feet. Building heights would increase to allow three-story structures built next to single-family homes. Off-street parking would not be required. Middle housing would be exempt from tree preservation standards. There are many more changes that go far beyond the state requirements and have negative impacts. HB 2001 provides the opportunity for Eugene to add housing and preserve neighborhood compatibility by simply implementing the minimum standards. There is no need to go beyond those requirements. The staff’s extreme deregulation will not incentivize housing that’s affordable to lower-income households. Instead, it will incentivize expensive, market-rate housing. City staff and councilors should make these proposals clear to the public in open meetings with comment opportunities. Residents must get involved to maintain their neighborhood livability. Bill Aspegren CLEAN WATER OR TWO ACRES OF TREES? The census report says Eugene added 20,000 folks in the last 10 years. Our southeast Eugene (where I’ve lived for over 30 years) NIMBYs would have you think half the people in Eugene support them. Survey those 20,000: Do you want two acres of trees for the southeast elite or a backup supply for clean drinking water? The answer is not rocket science. Don French DON’T THROW OUT VIRTUAL LEARNING As we approach the possibility of schools requiring remote school again this fall, the clarion call against remote learning is sure to rear its angry head. While I don’t disagree that schools that were never well equipped to handle virtual learning have tainted the entire concept of online classrooms, I still find it an unfair correlation. Virtual learning isn’t bad because it’s virtual. It’s often bad because the school wasn’t prepared to offer innovative, interactive online classes. This isn’t a dig on teachers who had to upend their classrooms and fully convert everything online. Instead, it’s an understanding that schools that weren’t already equipped for online learning can’t compete with schools that have it in their mission. This conversation has been focusing on the wrong things, and instead of touting either/or, why not both: blended learning. A 2021 Forbes article highlighted that blended learning is not a new concept for many forward-thinking schools like Le Sallay International Academy and Laurel Springs High School. Blended learning utilizes both online and in-person learning, giving students the best of both worlds. For schools that have built blended learning into their mission, the often touted “horrors” of remote learning are completely irrelevant. As technology evolves, so, too, should education. The pandemic has shown us that our traditional approach to education is in serious need of an overhaul. With so many educational options like blended learning available now, why choose schools based purely on proximity when we have the entire world in our laps? Mira Mason-Reader PLANNERS IGNORED PUBLIC INPUT The Eugene Planning and Development Department’s proposal for residential zoning changes to comply with HB 2001 deserves vigorous public outcry. I had decided not to worry about local HB 2001 compliance. I’m no fan of top-down, blanket-style zoning, but figured middle-type residential infill with appropriately scaled affordable housing had the potential to be fine. However, the city planners’ stated premise of making changes that correct historical inequity and create affordable housing has turned out to be hypocritical. The “public process” the city employed, while minimal and manipulated, revealed affordable housing to be people’s top priority. Yet, aside from aspirational wording, this public input went effectively unheeded. Compliance with the minimal HB 2001 requirements and using incentives, such as an overlay, set aside for affordable housing was an option; but planners chose to throw all the bargaining chips into the open (higher-cost) market. Additionally, their plan does nothing to prevent or address the otherwise likely net loss of currently more affordable older housing stock and the associated human displacement. Meanwhile, citywide homeowners living in areas unprotected by CC&Rs would be permanently at risk of losing valued features like privacy, trees and solar access as backyards are permitted to fill with taller structures and lots divided into as many as four parcels. This rezoning proposal’s numerous flaws are impossible to address in one letter. I implore people to inform yourselves about the details and implications and let your city councilor know what you think. There are better, greener options. Pam Wooddell NO TO RADICAL UPZONING Paul Conte’s Viewpoint (“Housing the Rich,” 8/12) is timely and spot on. I live in the Jefferson Westside neighborhood and have witnessed firsthand the complete disconnect when housing policy aspirations don’t match reality on the ground, and when older housing is replaced with high-end condos and apartments. I have also been party to sensible, community-driven solutions, not to one-size-fits-all zoning (Jefferson Westside Special Area Zone). It is a documented fact that Eugene has a housing shortage, but what is less well known is that the vast majority of the housing shortage is in the lower income strata. So yes, the wholesale demolition of older, relatively inexpensive homes in favor of high-priced multiplexes is increasing housing stock, but only in the upper income strata. In reality, this approach is exacerbating the lower income heart of the housing shortage. Eugene’s leaders should strive to maintain the current housing stock, while finding ways to subsidize the building of meaningful numbers of work force and affordable housing. Residential zoning should be nuanced and developed with the unique aspects of each neighborhood in mind. I have experienced the livability degradation and out-migration of long-term residents brought on by simple-minded zoning policy. Because the world is not black and white, the best solutions are found in the gray shades. Citizen involvement is key to good zoning. The proposed uniform, radical up-zoning of all Eugene neighborhoods is a bad idea. Details matter. Wake up, Eugene, before it is too late. Tom Happy WHAT WE NEED IS LOW-COST HOUSING Eugeneans, awaken! It seems to be human nature to not engage until something designed by someone else without our input is staring us in the face. “It” is Eugene building code being proposed to City Council by the Planning and Development to address HB 2001, the state’s mandate to increase different housing forms, e.g. duplex, cottage clusters, across single-family residential zones with the hope of improving housing affordability by increasing neighborhood infill. Eugene’s planning department, without supportive data, is going well beyond that which is required by the law. We need housing, no question, but the vast majority of housing that we need is affordable housing for our lowest-income neighbors. That does not happen without economic support, so what is proposed is housing deregulation. The city claims “filtering” will open up more housing for those with the lowest incomes as we build more housing. That is unlikely given so many of the lowest rent houses will be torn down to maximize a developer’s build potential. Where do those renters go? Another aspect of infill building is increased lot coverage, which equates to lesser green space and tree coverage, a direct hit against our commitment to climate recovery goals. Do some research for yourself. The planning department is sharing an incomplete picture, and instead of moving with caution, they are throwing all sails (equity, climate recovery) to the wind. Approved code is difficult to change. We need to get it right the first time. Less is better! Margie James PLANNING TO INCREASE CLIMATE CHANGE Recent articles highlighting the importance of Eugene’s tree canopy and the impact of heat islands or heat disparity have failed to note the absence of the Planning Department in this important conversation. One might assume that the planning staff is unaware of the discussion happening elsewhere in the city or, more likely, they’re being pushed beyond reasonable residential code changes by powerful lobbyists whose interests lie elsewhere. For example, the planning staff and commissioners are both currently recommending that the City Council “exempt middle housing from tree preservation standards” as part of upcoming residential zones changes. (Middle housing traditionally meant a small multi-unit building but that has now shifted to multiples of single family houses on very small lots.) At the same time, they are recommending minimum lot sizes so unrealistically small that with current property line setbacks (5 feet for interior and 10 feet front) new houses will entirely cover the remainder of the lot. There will be no practical room for trees, let alone gardens and play areas. It wouldn’t be surprising to see these setback standards decreased as well. The planning staff’s failure to address climate concerns is also glaring elsewhere. The most current recommendations to the City Council include elimination of on-site parking requirements in all areas. This one move will block the necessary shift to electric vehicles as residents will be unable to charge their vehicles. Unfortunately, vehicle ownership will be a necessity as public transportation is very limited in all neighborhoods with the exception of a few major corridors. Carolyn Jacobs Tags: letters / opinion I applaud Ramona Wise’s letter of Jan. 6 explaining why she didn’t have kids. I, too, made a conscious decision not to have children and … Continue reading →	cc/2022-05/en_middle_0076.json.gz/line30
__label__cc	0.56306	0.43694	How Would a New Bipartisan Bill that Encourages the DEA to Increase Opioid Quotas Affect Drug Manufacturer Efforts to Remain Compliant? Posted on March 28, 2018Emily BoydCategories Drugs & Devices, Regulation Emily Boyd Loyola University Chicago School of Law, JD 2019 After years in an opioid crisis, the United States now faces an opioid epidemic that has left the government and public desperate for relief and a workable solution. A group of senators hopes to be part of the solution with the introduction of a bipartisan bill that aims to better enable the DEA to establish opioid quotas. Despite already-present struggles to effectively manage its quota system and policies, the DEA would be given significantly more responsibility under this bill. Drug manufacturers, directly responsible for following DEA, FDA, and OIG regulations to hopefully resolve the epidemic, will need to grow their compliance efforts and create responsive solutions to remain both profitable and compliant. The Opioid Crisis, and current strategies to end it On October 26, 2017, acting HHS Secretary, Eric D. Hargan, declared a nationwide public health emergency regarding the opioid crisis. A problem since the 1970s, the opioid crisis in the United States is now a confirmed epidemic. HHS reports that in 2016 alone there were over 42,000 deaths from opioid overdoses and 2.1 million people with an opioid-use disorder, creating a $504 billion economic cost. After various federal and state actions to combat and help control the epidemic, HHS prioritized the following in its five-point Opioid Strategy in April 2017:: Improve access to prevention, treatment, and recovery support strategies Target the availability and distribution of overdose-reversing drugs Strengthen public health data reporting and collection Support cutting-edge research on addiction and pain Advance the practice of pain management. The American Medical Association (AMA), in recognition of “the need for increased physician leadership” in its own efforts to end the epidemic, created an Opioid Task Force. The task force encourages physicians to use drug monitoring systems, enhance training and education, support comprehensive treatments, aid in the elimination of stigma, prescribe naloxone (an overdose-reversing drug) to those patients at risk of overdose, and encourage safe medication storage and disposal. Opioid quota reform On Monday March 12, 2018, a bipartisan group of senators introduced a bill, the Opioid Quota Reform Act of 2018, that would allegedly “strengthen the Drug Enforcement Administration’s (DEA) ability to prevent opioid abuse.” With a current, limited ability to lower opioid quotas, the bill’s proponents claim that it would allow the DEA to weigh and consider abuse rates and overdose deaths in its annual quota setting for the Schedule I and II controlled substances manufactured and produced in the United States. Senator Dick Durbin of Illinois commented, “Opioid quota reform is needed so DEA can take important factors like diversion and abuse into account when setting quotas, rather than chasing the downstream consequences of this crisis.” In his reference to downstream consequences, Durbin implies that the introduction of quotas is an upstream solution, one that addresses “the underlying systemic causes, aspects, and issues at play.” The bill could move quickly, circumventing Congress through DEA’s administrative rule-making process. It is necessary to consider the compliance implications of this bill. Complying with drug quotas The DEA’s efforts to keep scheduled drugs under control culminates in the establishment of production quotas. The Controlled Substances Act allows the DEA to control the production of Schedule I and II drugs, including drugs used for research purposes. “These quotas—known as Aggregate Production Quotas (APQs), Bulk Manufacturing Quotas (BMQs) and Procurement Quotas (PQs)” set the legal production amount of each drug. However, the quota system has not always been well-received. “In 2011 and 2012, many patients with attention deficit hyperactive disorder (ADHD) said they found it profoundly difficult to obtain FDA-approved ADHD treatments containing amphetamine salts, a DEA-controlled substance. In response to pressure from patients and legislators, DEA eventually increased its production quota on amphetamines intended for sale from 25.3 million grams per year to as much as 49 million grams per year in 2014.” Critics of the DEA’s quota system argue that the troubles move beyond amphetamines and towards drug manufacturers. The quota system negatively impacts the drug manufacturers desperate to comply and maintain their businesses and profits. While manufacturers can make a direct request to the DEA for quota adjustments in the face of drug shortages, the Government Accountability Office (GAO) found that those requests for adjustments were often significantly delayed as compared to the DEA’s guidelines. GAO identified “significant weaknesses” in the DEA’s management of its quota process, namely that “[t]he agency frequently failed to meet regulatory deadlines for bulk manufacturing and procurement quotas, and on average took half a year to establish quotas in 2011 and 2012” A 2012 law requires the DEA to coordinate with the FDA to increase quotas. Therefore, in addition to the DEA’s troubles, “[m]anufacturers estimated that 17% of schedule II medicine shortages were caused by FDA between 2011 and 2013.” The DEA’s Diversion Control Division sets the Aggregate Production Quotas (APQ) for Schedule I and II controlled substances, and requires that manufacturers of these controlled substances apply for a quota. Drug manufacturers are expected to comply with quotas and the DEA’s process to obtain permission to manufacture their products. They must also remain abreast to changing quotas and laws in an effort to pro-actively prepare for increases and decreases that could dramatically affect production. They bear social and industrial responsibility for drug shortages and crises (like the opioid epidemic), but must also remain innovative and profitable through research and development and the sale of drugs that maintain their ability to invest in such endeavors. While not America’s favorite healthcare institution (Business Insider reports that despite an overall improvement in public opinion, drug companies continue to have a “so-so” reputation), drug manufacturers are not exempt from thorough OIG, DEA, and FDA compliance regulations. They strive to balance their goals and objectives with governmental and internal compliance oversight encompassing all seven elements of compliance. Would this bill create more compliance burden for drug manufacturers? The proposed bill asks a lot of the DEA. Senator Grassley of Iowa, one of the bill’s backers, lists the following changes to the DEA’s process: Directing the DEA to consider additional factors and existing statutory considerations in quota development; Requiring the DEA to publicly defend any annual increase to an opioid quota; Requiring the DEA to publish manufacturer trends and authorizations to Congress; and Requiring the DEA to identify better methods for incorporating data collection and changes in accepted medical practices. The DEA has documented struggles with adhering to its quota process and being able to assist the healthcare industry and drug manufacturers in responding to changes in drug availability. Is the introduction of more responsibility going to allow them to work with manufacturers, as they are expected to, and adequately respond to changes and developments in the opioid crisis and [hopefully] the crisis’ solution? Drug manufacturer compliance leaders must continue to ensure that their companies follow all new and existing rules and regulations despite the delay from announcement to implementation and the difference in expected interaction with the DEA and reality. Policies and procedures for DEA interaction will need restructuring, as the DEA’s response to its new reporting responsibilities will require data from manufacturers. Monitoring and auditing will hopefully remain the same as manufacturers should already be tracking compliance with existing quotas. Perhaps an increase in the oversight of opioids will influence positive change in manufacturers. It is hard to argue that efforts to combat the opioid epidemic should be questioned simply because they have a heavy impact on drug manufacturers. Those producing opioids should already be aware of the power they wield with such powerful, and presently deadly, medications supporting their business. Nonetheless, drug manufacturers must be aware that change is coming. Whether through this bill or the next, drug manufacturers will need to continuously work with the DEA to respond appropriately to the public and governmental demand for change, and with their own internal controls to ensure they remain compliant and prosperous. Tags Aggregate Production QuotasDEAdrug manuafacturersdrug quotadrug shortagesFDAfive-point opioid strategyHHSOIGopioid crisisopioid epidemicSenator Dick DurbinSenator Grassley Previous PostPrevious post:	cc/2022-05/en_middle_0076.json.gz/line35
__label__wiki	0.718536	0.718536	Comic 153 - Roadblock wasn't available. 4/21/14 Posted on Mon, April 21st, 2014 SKEET! SKEET! SKEET! 2/19/14 It's Dumb Joke Thursday! 2/20/14 It's a Company Man Classic! 2/21/14 Company Man Comic: Spotty at best! 2/25/14 SB1062, not even once! 2/26/14 It's Dumb Joke Thursday! 2/27/14 A Company Man Classic from 2/28/12 Trouble in Crimea! 3/3/14 Brought to you by: Chore Boy! 3/4/14 Nailin' Palin! 3/5/14 It's Dumb Joke Thursday! 3/6/14 Geeked yo' momma joke. 3/7/14 Edge: Bros. 3/10/14 Yo Mama Joke: Bunny Vomit style! 3/11/14 In honor of SXSW! 3/12/14 It's Dumb Joke Thursday! 3/13/14 We tackle the REAL news here! 3/17/14 Magically delicious? 3/18/14 It's all about Wes. 3/19/14 It's #DumbJokeThursday: Dental Edition 3/20/14 Brought to you by: Risperdal 3/21/14 Naughty By Nature would be proud. 3/24/14 Thanks to @AlYankovic & @Midnight for this! 3/25/14 It's Dumb Joke Thursday! 3/27/14 Don't stop, the readin'! 3/28/14 Guest strip week: Kevin Coulston! 3/31/14 Guest strip week: Gary Cohen, no foolin'! 4/1/14 Guest strip week: Geo Gant! 4/2/14 Guest strip week: Gary Cohen... again! 4/3/14 Guest strip week: Another Geo Gant couch gag! 4/4/14 More guest comic goodness: Gary Cohen! 4/7/14 Guest strip week: Gary Cohen... one mo' time! 4/8/14 Guest strip week: George Ford! 4/9/14 The FINAL guest strip: Darrel Troxel! 4/10/11 Guest drawn by Michael Bay! 4/11/14 A repeat performance 4/14/14 Today's comic won't go over well in #Malaysia! 4/15/14 The SPOILER Room! 4/16/14 It's Dumb Joke Thursday! 4/17/14 What we're made of. 4/18/14 Roadblock wasn't available. 4/21/14 Happy Earf Day! 4/22/14 Brought to you by: HTC ONE M8 4/23/14 It's #DumbJokeThursday 4/24/14 The Space-Racist! 4/25/14 My evil twin took over! 4/28/14 The evil twin has a fan? 4/29/14 It's Evil twin #DumbJokeThursday 5/1/14 Never give up hope! 5/2/14 Connor really dislikes Fergie. 5/5/14 Our news is dumb! 5/6/14 Derek V. V. Stiviano 5/7/14 It's #DumbJokeThursday Jewish Canadian Edition 5/8/14 The SPOILER Room! 5/9/14 SPECIAL #HappyMothersDay! 5/11/14 Brought to you by: #BaitCar 5/12/14 Eddie tries to help out. 5/13/14 The REAL Office Jesus. 5/14/14 It's #DumbJokeThursday: Yeah, they are Black! 5/15/14 Google #Brazzers logo, it's funny but very #NSFW! 5/16/14 Company Man Classic 5/17/14 Brought to you by: #SportsCenter 5/19/14 #DonaldSterling loves him some mistresses! 5/20/14 Lois & Clark at home. 5/21/14 It's #DumbJokeThursday 5/22/14 A Company Man Classic 5/23/14 A Company Man Classic 5/25/14 Brought to you by: #GM 5/26/14 A Company Man Classic: Brought to you by #StateFarmInsurance 5/27/14 If you don't know any Black people, you might not get this. 5/28/14 It's #DumbJokeThursday 5/29/14 Brought to you by: #Sharpie 5/30/14 #RIPAnnBDavis 6/2/14 Eddie gets serious. 6/3/14 #DonaldSterling & his mistresses! 6/4/14 It's #DumbJokeThursday 6/5/14 Don't burn up out there! 6/6/14 Sassi's #PhoenixComicon experience. 6/9/14 Ha! I had drawn it already! A Company Man Classic! 6/10/14 They had a conscious coupling! 6/11/14 #DumbJokeThursday it is! 6/12/14 Another mistress comes out! 6/13/14 #TheMoreYouKnow 6/16/14 #TheMoreYouKnow from Birdie! 6/17/14 #TheMoreYouKnow 6/18/14 #TheMoreYouKnow 6/19/14 Today's #TheMoreYouKnow and BOOBS is brought to you by #Risperdal 6/20/14 Guest strippin' done by George Ford! 6/24/14 It's #DumbJokeThursday 6/26/14 They have finally gone and done it! 6/27/14 Kids, right? 6/30/14 My cocaine. 7/2/14 It's #DumbJokeThursday 7/3/14 Happy 4th to all of my fireworks! I hate Michael Bay. 7/8/14 Where's he gonna go? 7/9/14 It's #DumbJokeThursday 7/10/14 I'm sure @StephanPastis has done this one! 7/11/14 #DonaldSterling goes to court. 7/14/14 Celebrity spotlight 7/15/14 4th wall still intact! 7/16/14 It's #DumbJokeThursday 7/17/14 We do it again! 7/18/14 This ain't no f@#king game! 7/21/14 Not a chance! 7/22/14 Finally, an #Obama joke. 7/23/14 It's #DumbJokeThursday 7/24/14 Travel day! It's off to San Diego! Here's an instant CLASSIC! #Arizona, it's a nice place, unless you're from #Mexico! 7/28/14 She has to have lightning fingers, right? 7/29/14 Sharknado 2: West Side Story! 7/31/14 Get all up in this! 8/1/14 Doobie-doobie-doo! 8/4/14 Happy belated birthday Mr. President! 8/5/14 Brought to you by: #SarahPalinChannel 8/6/14 It's #DumbJokeThursday #SharkWeek! 8/7/14 The Ace is in! 8/8/14 It can happen! 8/11/14 Weak weeks 8/13/14 It's #DumbJokeThursday! 8/14/14 Australian White Elephants 8/15/14 <a href="https://CompanyMan.thecomicstrip.org/comics/pl/402873"><img src="https://img.comicfury.com/comics/69/f60c4b617976128c71c2f130337dfb681893328948.png" alt="Company Man Comic - Roadblock wasn't available. 4/21/14" border="0" /></a>	cc/2022-05/en_middle_0076.json.gz/line36
__label__cc	0.595751	0.404249	PRE2017 3 Groep11 (→Package buyers (consumers)) ====Package buyers (consumers)==== Consumers require a delivery method that is affordable, fast, reliable and doesn't damage the package during delivery. Drone delivery is a good solution for these requirements of the consumers. Since drone delivery is expected to reduce the cost of package delivery, they can deliver packages withing an hour and the package is safely stored in the drone<ref name="Amazon prime air" />. However, the consumer has to be home to make sure that the surroundings of the landing platform are clear from dangers to the drone. The consumer requires an alternative to these landing platforms that are currently used. Having to be at home takes away from the ease of the delivery drone service. People require a delivery system where they don’t have to be home, without having to think about the safety of bystanders, potential theft of or damage to the package during delivery. Consumers are mostly concerned with the invasion of privacy that drones could possibly bring with them. People are scared that the drones can record their actions when the drones fly over their property. People can even feel oppressed or become paranoid because of the usage of drones<ref name = "Behavioral privacy" >Clarke, R. “The regulation of civilian drones impacts on behavioral privacy”, Elsevier (2014). Retrieved from https://www.sciencedirect.com/journal/computer-law-and-security-review</ref>. The landing platform has to take the privacy concerns of residents into account. Furthermore, the safety of drone delivery is often questioned<ref name = "Behavioral privacy" />. For people to be comfortable with using drone delivery system the safety of bystanders during the landing, drop-and take off has to be guaranteed. Consumers require a delivery method that is affordable, fast, reliable and does not damage the package during delivery. Drone delivery is a good solution for these requirements of the consumers. Since drone delivery is expected to reduce the cost of package delivery, they can deliver packages withing an hour and the package is safely stored in the drone<ref name="Amazon prime air" />. However, the consumer has to be home to make sure that the surroundings of the landing platform are clear from dangers to the drone. The consumer requires an alternative to these landing platforms that are currently used. Having to be at home takes away from the ease of the delivery drone service. People require a delivery system where they do not have to be home, without having to think about the safety of bystanders, potential theft of or damage to the package during delivery. Consumers are mostly concerned with the invasion of privacy that drones could possibly bring with them. People are scared that the drones can record their actions when the drones fly over their property. People can even feel oppressed or become paranoid because of the usage of drones<ref name = "Behavioral privacy" >Clarke, R. “The regulation of civilian drones impacts on behavioral privacy”, Elsevier (2014). Retrieved from https://www.sciencedirect.com/journal/computer-law-and-security-review</ref>. The landing platform has to take the privacy concerns of residents into account. Furthermore, the safety of drone delivery is often questioned<ref name = "Behavioral privacy" />. For people to be comfortable with using drone delivery system the safety of bystanders during the landing, drop-and take off has to be guaranteed. ===Society=== Members of group 11 C.J.G. Cartignij 1014018 K.D. van Kempen 1002991 W.W.A. Verhaegen 1024053 J.P. Versluijs 1019169 M. van Wiggen 1020451 1 Coaching Questions 2.1 State of the art 2.2 Problem statement 2.3 Objectives 3 Approach, milestones and deliverables 3.2 Milestones 4 Who are the stakeholders and what do they require 4.1 User 4.1.1 Delivery services 4.1.2 Package buyers (consumers) 4.2.1 Governments in urban planning 4.2.2 Regulation of drones 4.3.1 Delivery box manufacturers 4.3.2 Delivery box installers 4.3.3 =Drone manufacturers 5 RPC's 5.2 Preferences 5.3 Constraints 5.3.1 Annotations 6.1 Interaction platform-parcel 6.2 Lock mechanism 6.3 Location landing platform 6.4 Identification of right platform and drone 6.5 "MICHAEL system" [14] 7 Final design 7.1 Chosen Concept 7.2 Functions 7.3 Advantages 7.4 Disadvantages 7.5 Considerations for choosing this concept 8.1 NX drawings prototype 8.2 Materials and components needed for prototype 8.3 Lasercut MDF 8.4 Electrical circuit 8.5 Raspberry Pi 8.5.1 Simplifications 8.6 Realised prototype 9 Real product and pitch 9.1 Dimensions 9.3 Upgrades 9.4 Product pitch 10 Accountability 10.1 Product accountability 10.2 Accountability of the drone landing platform 10.2.1 Annotation Coaching Questions Group 11 Here, the current state of drone delivery technology will be explained. From this, a problem statement is derived in order to solve a current problem for the technology and objectives for this project will be stated. State of the art research A lot of scientific research is currently being done on the implementation of drones for delivery purposes. However, this research mainly focuses on the routing of the drones[1], the avoidance of mid-air collisions[2] and privacy aspects[3]. There are almost no sources on the delivery itself. On the other hand, there are some conceptual US patents describing drone delivery receptacles[4][5][6][7]. The problem that is still present with these concepts, however, is that these concepts are mostly implementations for a smart home and can only be used in one specific situation. Thereby, these concepts are only applicable for people who have a house and not for, for example, flats. Therefore, it is needed to make a simpler system that can be used in multiple environments. The usage of drones has become popular in various fields of work and also for recreational use. Drones have a promising perspective in a lot of different areas, like military, surveillance and package delivery. The problem that will be tried to solve in this project is the problem of the actual delivery around the house. In the current state of drone delivery, the buyer needs to place a landing pad in a place with enough free space around it[8]. Thereby, the buyer needs to be home when the delivery is done, since the landing pad could be blown away due to wind for example. Furthermore, the way drones are delivering now can be harmful for bystanders, such as kids and pets that do not understand that the rotor blades could be harmful[2]. Also, the drones themselves can be broken if it collides with something. These problems make drone delivery far less easy than it would seem at first. Furthermore, the packages that are delivered are easily stolen and certain weather conditions could be harmful for the package. The last meters of the so-called “last mile delivery” contain multiple problems that need to be tackled before the drone delivery system can really become mainstream. A solution to these problems could convince governments and NGO's to legalize drone delivery[2]. A certain landing pad that has its own designated place, that can hold the package for a sufficient amount of time and is weather/theft proof could be a solution for these problems. The goal of this project is to make such a platform. Develop a platform/device on/in which a drone can safely drop off a package, considering the following components: The dimensions of the parcel, which is carried by the drone The landing platform for the drone at the delivery address Risk of theft Location of the landing platform Safety risks for bystanders Risk of weather damage Approach, milestones and deliverables This chapter will discuss the approach of this project and will give an indication of what can be expected when the project is finished. Firstly, literature will be studied in order to figure out to what extent the project case has already been researched. After that, the present day problems with the technology will be determined. A list of RPC's will be made, based on USE analysis and technological requirements. With that list, concepts will be created, of which the best concept will be worked out and made into a prototype. In the design process, it is very probable that it is needed to go back a step to eventually make a better design. In the design phase it may be need to measure the drones that are available in Gemini to determine the final measurements of the design. Lastly, in the testing phase, a drone will be used to check if the system reacts to a flying drone like designed. Literature study Sources read Sources summarized Conceptualize RPC's Concepts/drawings of concepts Decide a final concept Work out concept Choose/order materials Choose/order operating system/electronic parts Costs overview Building/assembling prototype Test prototype Conduct a survey about the prototype A technical report of the design process(Wiki) A prototype of the landing pad NX design of the prototype Final presentation explaing the design process and showing the prototype Who are the stakeholders and what do they require To be able to solve the problem statement the different stakeholders and their needs need to be taken into account. These stakeholders and their needs are discussed below. One user group of the new product will be delivery services. They can use the delivery box/platform as a faster and cheaper way to bring their packages to the customers[9]. A problem of this is that not every country allows drones to fly everywhere, because of privacy. Because of this, the delivery services have to make sure and prove to the government that they do not save imagery. A benefit from the new technology is that the company can deliver packages way faster, namely in less than an hour. This is also very useful for customers because, if they need something quickly, they will no longer have to leave the house. As delivery services become more useful for customers, more people will use the delivery services and the delivery companies will grow. Another benefit for the delivery services is that by using a drone the delivery process will be much cheaper than when the company has to hire a driver. Another thing that makes the delivery cheaper is that the delivery time is way shorter. That means that more packages can be delivered in a shorter time. In short, more customers and faster delivery times ensure a huge growth for the delivery services. Package buyers (consumers) Consumers require a delivery method that is affordable, fast, reliable and does not damage the package during delivery. Drone delivery is a good solution for these requirements of the consumers. Since drone delivery is expected to reduce the cost of package delivery, they can deliver packages withing an hour and the package is safely stored in the drone[9]. However, the consumer has to be home to make sure that the surroundings of the landing platform are clear from dangers to the drone. The consumer requires an alternative to these landing platforms that are currently used. Having to be at home takes away from the ease of the delivery drone service. People require a delivery system where they do not have to be home, without having to think about the safety of bystanders, potential theft of or damage to the package during delivery. Consumers are mostly concerned with the invasion of privacy that drones could possibly bring with them. People are scared that the drones can record their actions when the drones fly over their property. People can even feel oppressed or become paranoid because of the usage of drones[10]. The landing platform has to take the privacy concerns of residents into account. Furthermore, the safety of drone delivery is often questioned[10]. For people to be comfortable with using drone delivery system the safety of bystanders during the landing, drop-and take off has to be guaranteed. Governments in urban planning Governments can have a huge impact on the success and eventual implementation of the delivery drones. Governments are in the position to make future neighborhoods, that still have to be build, delivery drone friendly and change current neighborhoods to be delivery drone friendly as well. To be delivery drone friendly, the government can implement designated landing spots for delivery drones, that are easily accessible for the residents. There are multiple ways to add this functionality and different options may be chosen for different neighborhoods. Possible options are: Make a central point for all the drones to delivery its package, make landing spots between 2 houses as a shared depot or give every buyer of a future house the option to implement a landing spot in the roof. As can be seen the governmental influence in this new technology can be quite substantial. For the privacy issue explained in the previous section, the place of the landing pad can have a huge impact on how invasive residents find the delivery drones. For the government it is easier to implement this new function in all the newly build homes and neighborhoods without being invasive, then it is for individuals. E.g. the government can build more easily in the front side of the house, the place where people find the delivery drone technology less invasive. For the government itself, focusing on this technology in urban planning there is much profit to be made in the happiness of the residents. There are less delivery people on the street, which is good for the environment and helps to keep streets in living areas quiet and safe[9]. The governments stimulates the economy, because more people are able to quickly order products from enterprises[9]. Putting time in this system during urban planning can increase the feeling of privacy the residents in urban areas have. Regulation of drones Privacy was mentioned in the part of consumers/buyers as an important issue against the use of drones. The government can enforce laws for delivery drones services to make sure that the delivery drones do not safe any visual input needed to move around. People would become reassured that the delivery drones that flies over their back garden doesn't make any recording of what they see, thus safeguarding privacy. The government can enforce other laws that the delivery drones are easily distinguishable from reacreational drones. This way people now what is flying over their property. One last point where the urban planning of the government is important is the regulation of the air traffic of the drones. Drone delivery as a new technology suddenly fill the air with a new form of transport that wasn't used in urban areas before. The government has to regulate the air traffic of the drones with clear laws, this to prevent annoyance of residents towards the drone delivery infratructure and system. Delivery box manufacturers The manufacturers want to make a product that is cheap to make, so they can sell it for less and eventually sell more. The production of the designed delivery box isn’t a really cheap production. An advantage of this product is that it reaches a large target group, namely anyone who uses delivery services to order products. Because the target group for this product is so high, it is relatively easy to achieve a high turnover. And with a high turnover, no very high profit margin is needed, so that the product can be sold even cheaper. Another benefit from this delivery box is that it is applicable on any living situation, so every delivery box can be made exactly the same. The fact that the target group is large and the fact that the product can be used in every living situation ensures that mass production will be possible for this product, so it can be manufactured cheap and thus can it be sold relatively cheap. Delivery box installers The platforms where the package will be brought to has to be built in or around the place where the customer lives. For some customers this is easy, for example people with a large garden or a large balcony. But there are a lot of living situations, like flats or terraced houses where the customer can’t build the platform on his house himself. A benefit from this is that many people need to do a small renovation to their house, to place the platform. Many construction workers can, with a little extra training, learn how to install platforms on houses. With the ability to place platforms on houses, the target group of those companies gets a lot bigger, because a lot of people need them for the new technology. This means that there will be more work for construction workers and thus will those companies grow bigger and have increased sales. =Drone manufacturers If most of the delivery is done with drones, then drone manufacturers will have a larger market to sell their drones to. If this manufacturer needs sell more drones, then they have to produce more drones. The company has to find a cheap way to produce these drones, so they can sell them for less and eventually sell more of them. A way to produce the drones in a cheap way is mass production. The drones also have to be able to work with the new delivery system, so they can be used for that. The drones need to fly very careful because of possible fragile products and the drones need to have the correct dimensions for landing on the platform. Once the new delivery system has been implemented, the company must continue to develop the drones, so that the delivery continues to improve and the drones keep being sold. In this chapter the requirements, preferences and constraints for the final product are listed. There should be a clearance of 50 cm from the center of the platform to any other object, so there is enough space to let a drone land.* The package casing must be weather resistant in normal conditions. The package can’t be damaged by rain, wind, hail, snow and debris flying around The platform must be able to be used by more than one person Requirements of the government for unlicensed building*[11] [12]: Back/front garden Maximum area of 2 m² Roof on back side Have a flat roof or, Can’t stick out of the roof more than 1.75 m 0.5 – 1 m of space to between all sides of the roof and the construction The platform should be as compact as possible The platform must be placed in such a way that people can easily access it The package should not encounter too much impact The landing platform should be cheap Notification should be send when package arrives The platform should be installable in a wide range of environments The platform should have a neutral appearance Platform and drone can identify each other, to insure the right package is delivered at the right platform The platform must be able to cummunicate whether there is room for a new package The package casing must have a lock mechanism A drone must be able to drop a package on/in the platform without damaging it The drone may not cause harm to people/pets/other obstacles The platform must be able to receive a package of max 2.25 kg[9] and size of 40 x 40 x 40 cm[13]. The dimensions of the drone that, for instance, Amazon uses is not publicly availlable. The delivery drone system is still in development and is not publicly implemented yet. Due to the fact that the system is still in development, the information about the system and therefore drone size is very limited. The 50 cm clearance on all the sides seems to be a realistic value considering the estimated size of the drone, platform and packages. These requirements are based on the unlicensed building criteria of the dutch government. There are not any specific building criteria for our landing platform, due to the fact that this is a fairly new idea and no existing patent has been fully worked out. These building requirements are often very case specific, thus certain requirements can be changed if our idea is implemented in the real world. The dimensions of the system may have to change to remain within the unlicensed building category. The current requirements are the best guesses for now.** Here, all potential concepts will be listed. They will be categorised for some parts of the design, since all things of all categories can be combined to make a final concept. Interaction platform-parcel The platform is a locked box, in which a drone can drop a package; later, the customer can open this box itself and retrieve the parcel. The done carries a box with a lock; the base will lock it in place with an arm / magnet / gripper / etc.; the box can be returned, so it can be reused (like a packaging deposit system) Drone carries a waterproof box; the base will put a cage around it. A hole in the ground that opens when the delivery is done. The rest of the time it's closed so it seems to be a normal tile. The platform is raised high, for instance set on a pole, where the package is stored. The package can be retreived by lowering the platform to ground level. Lock mechanism Movable box carried by drone. The side of the box that can be opened is faced down, so potential thieves can't open it. Code lock (bar, QR, password), of which the code could be shared with the recipient via email for each parcel. RFID lock (using mobile phone NFC chip), of which the code is shared with the recipient via email for each parcel. Physical key Location landing platform Out of a window(maybe attached to wall in order to keep window closed). Drone can enter specific part of house. Attached to the wall next to the front door. For appartments: a room easily accesible for drones where a certain amount of landing platforms are(Package need to be retrieved in x minutes, so it can be used by other residents). Identification of right platform and drone Radio / IR / other radiation to transfer information Box opens after estimated delivery time has gone by. "MICHAEL system" [14] Shared landing platforms for all the people in a neighborhood. Flying drones to deliver to this point. Driving drones deliver to front door. Or, People retrieve the package themselves from the landing pad. Final design This chapter will explain the chosen concept and give all considerations for this choice. Chosen Concept The concept is the one where the platform is a closed box, in which the parcel will be stored. This platform is shaped like a simple rectangular box, divided into two compartments. The top compartment contains two cylinders, one inside the other, rotating around the same axis. These cylinders act as the acces for the drone, through which the parcel is transfered to the bottom half. The outer cylinder acts as a door of the platform, closing the exterior of the housing. The inner cylinder has a vacancy to accept the packages and guides them to the bottom compartment. These cylinders turn simultaniously, but in opposite direction, in order to open or close the platform for package transferal. The second compartment is the storage area, which can be accessed by the user via a seperate locked door. This storage compartment also contains a lift on which the packages are placed by the cylinders. The lift lowers the package into the storage compartment, to make sure the package doesn't drop too far and to make room for another arrival if any space is left. The system can be placed on various locations, but most interesting is building it into the roof, since this adds additional protection and can help increase privacy and safety. Communicating platform location Link to internet Communication with ordering services Notifying user(s) Identifing authorized drone(s) Various options for lock mechanisms Dependent on intended use Supporting multiple users Suporting multiple packages The systems has no out / inward moving parts The drone can't be obstructed/blocked because of these parts This keeps the platform compact Can be placed in various environments The design is efficient and secure The system is anti-theft because of the identification codes and anti-theft casing The system can be shared with multiple people(depending on the location of the system) Relatively many and complex moving components. Increases material demands Increases costs Optimal placement requires: Possibly a building license For existing homes: Additional funds Additional time Considerations for choosing this concept The "MICHAEL system"[14] seems to not be a viable concept to use for our landing pad. The designated landing pad that can be used for multiple people is hard to implement in already existing neigborhoods, since a decent area is needed to work out the concept, which may not be available. Then the person has to either walk to the landing spot to get their package, or they have to be home for the driving drone to deliver the package from the landing area to the front door. This takes away from the ease that is strived for when using the delivery drone service, since you have to be home for to obtain the package. Another way is to have your own box where the driving drone delivers the package into, but then it becomes even more expensive then it already is. Futhermore, the reason to have a shared landing spot in a neigborhood completely fails if people need to get their own safe box system as well. For the location, the front side of the roof the best location for the landing pad, taking into account all the stakeholders. The front side of the house is considered less of a personal space as the back side of the house. Therefore placing the box on the front side of the house will safeguard the privacy more than placing the box on the back side of the house. The roof is a better location than placing the landing pad on the ground for multiple reasons. If the landing pad is placed on top of the roof, the package can't easily be stolen by thieves and the drone is less vulnerable during descent. The drone can spot the landing pad more easily on the roof than when it is on the ground[15]. The safety of bystanders is taken into account as well, since there are no direct bystanders like excited pets or kids that can interfere with the system. The only downside is that for already existing homes, it will cost extra money to install the system onto the roof and a building license is needed for the front side.[11] The enterprises want to have a reach that is as big as possible. Taking into account the whishes of the enterprise, the system is also usable in the front and back yard, and the back side of the roof. The system works in these locations in the same way, the difference is that it costs less money for people to use the system and a building license isn't needed. However, the system is less optimized in terms of privacy and safety for these locations. Therfore, the help of government in urban planning is asked. With the help of the government, people get the chance to build the system into their future house, getting an optimal service. Adding the protection of the box already before shipping will cause more problems than that it would solve. Examples of these system are concepts 2 and 3. These systems put too much of a burden to the enterprises. These enterprises need to invest a lot of money for all these boxes, and it costs an extra flight for every package to return these protecting boxes. Moreover, doubeling the amount of flights would quite possibly annoy consumers. And the extra weight of the protected boxes would either result in a change of drones or a lower maximum weight of the packages. Therefore, these systems aren't chosen for the final concept. Concepts 2 and 3 wouldn't be optimal, because the moving parts can easily obstruct the drone while delivering the package. Furthermore, these systems can only be used on the ground for save access to the package. Endangering people into these activities is counter productive and putting the system on the ground was a less optimal choice as explained earlier. Concept 4 seems to be a less optimal choice for the same reason. Concept 5 does not have this problem. However, the system would both be an eye catcher, which is not desired, and be realatively vulnerable. To realize the identification/lock of the system on the recipient side, several options are chosen. Depending on the situation one is favoured over the other. Bar/QR codes, RFID/NFC, passwords and physical keys have been selected as viable options. When the landing platform would be shared by multiple households/users, a bar-code, QR-code, RFID/NFC or a personal password could be used. For this situation, the preferred method is to use a bar or QR code. The code can be assigned to an individual person and stored in a physical or digital form. The physical form could be used in a system where the box is assigned to an individual for an extended period of time, so no additional device is needed to acces the box. However, this is a less secure option, for the code can be copied. If a more physical form is desirable, a NFC system would be more secure. In digital form, the code can easily be distributed to users, for instance via e-mail or a seperate app. In addition, the required code can be automaticly changed allowing for a one time acces. When the landig platform would be used by a single household or individual, the disired form of identification is more dependent of personal preference. NFC, passwords and physical keys would be prefered solutions. Either of these systems have their own advantages and disadvantages, but it must be mentioned that lockes with physical keys are more vunerable. The user would choose its own prefered system. In order for the landing platform to be effective it needs to have interaction with the drone. It was chosen to outfit delivery drones with QR codes based on which they can be identified by the landing platform. From an average camera, the distance at which a QR code can be scanned is about 10 times the width of the QR code itself[15]. It is the intention that the QR code can’t be scanned too soon, because then the platform will be open unnecessarily long. A QR code of 2 x 2 centimetres has been chosen, which means that the code can be scanned from 20cm distance. This way the QR code can only be scanned once the drone has landed on the platform. An automated system could keep track of which drone delivers a certain package, the corresponding identifier could be communicated to the platform in advance. Because commercial GPS has a limited accuracy [16] the drone needs to be able to identify a landing platform and preferable its orientation to ensure a smooth approach. For this purpose, the landing platform has visual markers from which the drone can gather this information. These visual markers would include a standard patern of colors and shapes that signal both the orientation and that it is a landing platform to the drone. In addition, the platform requires to communicate its identity to the drone. For this function, the landing platform could contain a RFID tag which can be accessed by the drone upon landing. The major disadvantage of such a system is the short range at which the RFID tag works, but it requires a little amount of energy. The drone could also access the landing platform's internet connection providing a much bigger range. A major advantage here is the ability to verify the platform's identity at a distance, leaving the drone less vunerable. In this situation, the platform would would act as a hotspot, requiring aditional power. In order to test the viability of the concept a prototype was constructed. Due to the limited time frame the focus lay on the most important functions: The cylinders responsible for accepting the package, The storage compartment including the lift and drone recognition. The shapes cylinders have been approached by discs seperated by multiple rectangular plates. They turn round the same axis using a set of planetary gears, chosen to keep the system as compact as possible whilst maintaining reliability. The lift is a simple platform held aloft by four kabels. These are wound up round an axel, connected to the platform, to lower or raise the platform allowing to lower items into the storage compartment. A simple webcam fullfilled the requirement to read QR codes, providing or denying access to the storage compartment. Items can be retrieved through a separate door closed by a simple lock. NX drawings prototype Firstly, a 3D-sketch of the prototype has been made using Siemens NX. The 3D-sketches could be easilly evaluated by constructing a digital assembly containing repesentations of other elements such as the bearings. This enabled quick spotting of errors concerning the dimensions and clearances. It sped up designing whilst reducing errors and provided extra insight and understanding of the system. In these designed, construction is already accounted for, as can be seen in the edges, where holes and slits have been made, in order to bolt the parts to each other. Below, the final sketches of the prototype can be seen. The left image shows the outside of the prototype. In the middle picture, the side wall has been removed, so the planetary gears driving the cylinders can be seen, just as the platform that keeps a package from falling from too high. The right picture shows the inner cylinder (in grey) and the outer 'cylinder' (in red). The inner cylinder receives the package and rotates to drop it in the compartment below. The outer cylinder keeps the package from falling out of the inner cylinder before it has completely rotated and also serves as a roof. Only the electrical components haven't been added in the assembly. 3D sketches prototype Total prototype Prototype without side wall Materials and components needed for prototype In order to make the assembly, several materials and components are needed. These things can be seen in the table below. Ordered? Paid By Raspberry Pi 3 Model B 1 € 37.49 SOS Solutions x Camiel Micro SD Memory Card 1 € 0 Borrowed (Camiel) x Camiel Raspberry Pi Case 1 € 0 Borrowed (Camiel) x Camiel Raspberry Pi Power Supply 1 € 0 Borrowed (Camiel) x Camiel 5V 2A Adapter 1 € 8.00 Tinytronics x Camiel Continous servo 2 € 16.00 Tinytronics x Werner Breadboard 1 € 2.50 Tinytronics x Werner Male-Female Jumper Cables 20 € 1.50 Tinytronics x Werner Male-Male Jumper Cables 20 € 1.50 Tinytronics x Werner DC Jack female adapter 1 € 1.00 Tinytronics x Camiel AA Battery 12 € 6.99 Conrad x Camiel USB camera 1 € 13.49 Conrad x Camiel Ball Bearings 6 € 14.94 Conrad x Camiel MDF (laser cut) (4x600x300mm) 4 € 44.35 DigiFab x Jasper Simple lock 1 € 10.95 Hornbach x Camiel Hinge 2 € 3.40 Hornbach x Camiel Dowel (8mm x 100 cm) 1 € 0.50 Hornbach x Camiel Bolts and Nuts (M4 x 16mm) 30 € 4.58 Gamma x Camiel Bolts and Nuts (M4 x 20 mm) 30 € 4,98 Gamma x Jasper Kill Switch 1 € 0 Borrowed (Camiel) x Camiel Fishing line N/A € 0 Borrowed (Michael) x Michael Total costs € 172,17 Lasercut MDF The prototype is made out of MDF, Medium Density Fibreboard. This MDF is lasercut into the correct shapes, as shown in the following figures. These sketches have been made by converting the 3D model to a series of 2D components, after which the components have been cut out in a laser cut machine. The resulting lasercut sheets that have followed from the conversion to 2D can be seen below here. The actual manufacturing of the parts was outsourced to an external company handeling laser cutting and CNC milling of various materials. Lasercut MDF images Electrical circuit In order to be able to assemble the prototype safely and quickly, a schematic overview of the wiring of all electrical components has been made as well. This overview can be seen below. In order to control the electrical system of the prototype a raspberry pi model 3B is used. The prototype needs to have a QR-code scanner. A simple controller like an Arduino is not sufficient, since the graphical processing requires more processing/memory power than an Arduino can deliver. Therefore, the logical choice went to the Raspberry Pi 3B. The dimensions of the Raspberry Pi are 9x6x3 cm. With this system two continuous servo's and a camera are controlled. The two continuous servos are needed in order to rotate the cylinder and to move the lift. The camera is needed for checking the QR code on the drone to see if the drone is on the right platform, and to make sure the platform only opens when the QR code is verified. To control the raspberry and said system a program has been written with python. This program can be found here: PRE2017_3_11_Python_Code. In this code, the servos are controlled by sending a certain pulse width modulated voltage to them, by using the "RPi.GPIO" package. This only happens if a correct QR code is read. The QR code reader is defined as a function, which uses the "pyzbar", "Image" and "cv2" package. "pyzbar" is a QR code reader, "Image is an image reader" and "cv2" reads the feed from the webcam. If the QR code equals one of the codes in the database, the platform opens, if a code which is not correct is read, the platform stays closed and transmits a message. Simplifications Due to impracticality and high cost, the prototype misses some features the actual product will/could have, but aren't vital for a proper demonstration. These are listed here: Currently, the program reads permitted codes from a file on the raspberry pi ("authcodes"). In a real life application, it could get these files from a secure web server which communicates with the delivery service. This way the program can be activated, only when a drone is on the way The program currently closes the cylinder after a certain time interval. In a real life application, a sensor will be inserted in the cylinder, which detects when the package is dropped, gives off a signal, and immediately closes the cylinder. A sensor could for example be a force sensor. In the prototype, the platform moves down all the way when a package is dropped on it. In a real life application, the platform could move down just far enough to clear the cylinder. This could be measured with a laser sensor. This laser could be located right below the cylinder, and get blocked a package. When the platform moved far enough down, the laser is no longer blocked, and a signal is sent to the controller, which stops the platform from moving down. This way, multiple packages can safely be stored in the box, without some of them falling a long way. Also, the receptacle can calculate the space left, in order to see if a new parcel can be delivered. Realised prototype Youtube demonstration video In the following link, a demonstration will be given of the functionalities of the prototype. https://www.youtube.com/watch?v=O3DlDyHigvc Photos of prototype and components Below, a number of photos can be seen of the prototype during multiple stages of the building process: The first three images show the finished product The fourth image shows the bottom of the platform with the servo and axle, that will rotate to roll up the wires in the four corners of the platform, so the platform will move up (or down, when the servo and axle rotate back again) The fifth image shows the inner cylinder with its gear Image six shows an isometric view of the inside of the receptacle without the cylinders; the platform can be seen on the bottom Picture seven shows a sideview of the inside of the receptacle, without the cylinders and the platform Picture eight shows a front view of the receptacle with the door opened. Also, the platform can be seen hanging. Realized prototype gallery 1. Closed cylinder 2. Half-open cylinder 3. Opened cylinder 4. Bottom view of the platform with servo and axle to move platform 5. Inner cylinder 6. Isometric platform view without cylinder 7. Opened sideview without cylinder or platform 8. Closed platform view Real product and pitch The prototype shows the viability of the major systems discussed in the concept. However, it is not suited for real life application. Therefore, this part will discuss the various changes needed to make it applicable in a real situation. The ratio between the prototype and the real product is 1:4, which means that the dimensions of the real product are 65 x 65 x 130 cm (l x w x h). MDF would not resist the outdoor elements, thus different materials need to be chosen. The housing will be constructed out of stainless steel for durability and strenght. It would provide the product the resitance against damage to prevent theft. The housing will be covered by a layer of weather resistant, durable plastic, making the platform less of an eye catcher whilst limiting the steel's exposure to the elements, yielding more durability. Moving components, such as the gears and the cylinders would also be crafted from stainless steel for both strenght and durability whilst the platform can be made out of plastic. The finished product would naturaly have the functionality previously mentioned in the Concept chapter, but it would also recieve various upgrades compared to the prototype. The real product would need an aditional comparment to store components such as the electrics, which is not implemented in the prototype, because easy access was needed for bug fixing. This would result in a slight increase in width. The gears would have additional clearance from other components. The outer cylinder would be guided by aditional bearings reducing strain on the axle, improving strenght and structural integrity. In addition, the cylinder would receive its own mechanism to lock into place when closed, to help prevent possible damage. Also, the outer cylinder would be sealed with rubbers to make it waterproof. Another improvement for the inner cylinder is the installation of a pressure sensor, so the device will know that a parcel has been dropped, so the cylinders can close again. The cables in the lift would be either covered or replaced for additional protection from wear. The lift itself will receive additional guidance for a smoother motion. The inventory management sytem would be able to keep track of the available space in the storage compartment and the presence of packages in the cylinder and could inform the user of package arrival and space limitations via the link to internet. Lastly, the lock providing the user access to the storage compartment would be upgraded to the desired system and required standarts. Product pitch The usage of drones has become popular in various fields of work and recreational use. One promising new field of use for drones is package delivery. However, there is still a number of problems that need to be solved. Therefore, a conceptual design of a package receptacle has been made, which tackles a veriety of problems concerning the actual delivery of packages at the customers address by drone. For example, Amazon currently uses a plastic sheet, which a customer should put on the ground, to indicate the place of delivery for the drone[8]. This, however, shows various flaws: The package is not protected against theft or influences by the weather. This can lead to damaged or stolen goods, which is desired neither by the recipiant nor the shipper nor manufacturer. The drone can not tell one plastic sheet from another beyond the general location, which could result in packages being delivered at wrong adresses when different people order products in close proximity. It could also be used as an easy method of intercepting both the package and the drone. The recipient has to be at home for delivery and observe the sheet to prevent theft or damage. this is a major irritation for recipients with current delivery services as was concluded from the project of Group 10[17]. This design protects against theft and exposure to the elements by providing a safe and easily identifiable package receptacle in the form of a landing platform. It is permanently placed in private or restricted areas and developped mainly for usage by a single household or individual. However, with slight modifications that do not require aditional funds, it can be made suitable for shared access. For additional protection and convenience, the platform can be incorporated in the roof of a building. The storage compartment would be reachable from the inside of the house and intercepting the package or drone has become harder. In addition, the recipient does not need to wait for the package's arival. Besides adressing these problems, the system also has additional functionality such as notifying the recipient of package arrival and remaining storage capacity. The designs benefits are not limited to the recipient of the package, the shipper can serve his customers faster and more accurate, reducing costs and risks, whilst keeping their clientele satisfied. In addition it provides structure to the logistics of drone delivery. There are many situations where the producer of a product can be accountable for damage suffered by consumers. A lot of these forms of accountability aren’t described here, since these are forms of accountability that are not product specific for the landing platform. For example, a customer of the landing platform can be attacked by the installer of the platform. The company has accountability since the installer is their employee. The project focusses on the landing platform, therefore the product accountability will be explained further below. Product accountability In problematic situations with a product, the producer of a product can be held accountable for the damage the consumer has suffered. There are several guidelines where the producer and customer have to pay attention to considering accountability. The customer is in the disadvantageous position, since there is only one guideline: [18] The consumer that wants a compensation for the damage suffered has to prove that there is damage suffered, that the damage is caused by the product and that the product was used as intended while dealing the damage. For the producer the following guidelines in dealing with accountability are set up by the European Union[18]: The producer has to deliver clear warning signs and a clear user manual. The producer of the product is accountable if the product fails to meet safety standards, and that the product is dangerous to use. The producer is not accountable if it was impossible to predict that the product was indeed dangerous to use, the product became dangerous because of deterioration or the damage was caused because of misuse of the product. Accountability of the drone landing platform In the situation that the consumer misuses the landing platform and ignores the warnings given on either the platform itself or the user instructions, then the consumer is at fault and is the one accountable for the damage. One could think of a situation where a person puts his or her hands between the rotating cylinders of the platform when a drone just opened them, or between the rotor blades of the drone. The consumer buys a platform to be able to safely use the delivery drone system, the action of the users is clearly misuse of the system and the first guideline for producers is followed. In the situation where the package is stolen or damaged and the platform hasn’t taken too much damage, then the producer of the platform is accountable for the damage suffered. The producer claims to deliver a system that secures the package from damage and theft, in such a scenario the producer has failed to deliver what it claimed to deliver. However, if the landing platform is in a severely altered state then the producer isn’t accountable for the damage suffered. The landing platform is already on the roof to reduce risk of theft, when the platform has been altered in a significant way then the producer is not accountable. The owners and residents are expected to notice such an aggressive act towards the landing platform. In the same way that people are expected to notice when someones front door is damaged in such a way that the people can easily enter the house. In short, the system is anti-theft, but this is only to a certain point. After that point the producer can't do anything against the theft, and the producer isn't considered accountable. The producer is not accountable for damage or privacy claims when the platform isn’t placed on the roof of the consumer. The product has a clear description that to be able to deliver complete safety for bystanders, safety against theft and safeguard privacy the system has to be placed on top of the roof. The system does work in other places, like the backyard, and the system is legally allowed to be placed there. The system isn’t on its optimal place and this is regarded as misuse of the system. If the system opens when there is no drone, the wrong drone or stays open when a drone has left, then the producer is responsible for the damage the package has taken and possible the house of the consumer. The producer claims to deliver a system that secures the packages from theft and damage, in this case it has failed to deliver this claim. If there is a communication problem with the drone and the landing platform and this causes damage then the producer is responsible for the damage. The same counts for when the consumers can’t open the door to retrieved its package, and a mechanic has to come. The costs of the repairs are our responsibility. The producer claims to deliver a system that is easy to use, in this case it has failed to deliver this claim. The cases of accountability described above do still rely on the guidelines of the European Union, meaning that the consumer has to prove that certain damage is caused by the platform, that the platform is used appropriately and that no damage has been done earlier to the platform. Planning Group 11 ↑ Coelho, Bruno N.; Coelho, Vitor N.; Coelho, Igor M.; Ochi, Luiz S. ; Haghnazar K., Roozbeh; Zuidema, Demetrius;. Lima, Milton S.F; da Costa, Adilson R., "A multi-objective green UAV routing problem", Elsevier, (December, 2017) https://www.sciencedirect.com/science/article/pii/S0305054817301028?via%3Dihub ↑ 2.0 2.1 2.2 Anbaroğlu, B., " Parcel delivery in an urban environment using unmanned aerial systems: a vision paper", ISPRS, (November, 2017) https://www.isprs-ann-photogramm-remote-sens-spatial-inf-sci.net/IV-4-W4/73/2017/isprs-annals-IV-4-W4-73-2017.pdf ↑ Lidynia, Chantal; Philipsen, Ralf; Ziefle, Martina, " The Sky’s (Not) the Limit - Influence of Expertise and Privacy Disposition on the Use of Multicopters ", Springer, (June 21, 2017) https://link.springer.com/chapter/10.1007/978-3-319-60384-1_26 ↑ Walsh, R., & Falesch, A. J. (2015). U.S. Patent Application No. 14/587,828. https://patents.google.com/patent/US20150183528A1/en ↑ Shucker, Brian Daniel, and Brandon Kyle Trew. "Machine-readable delivery platform for automated package delivery." U.S. Patent No. 9,864,967. 9 Jan. 2018. https://patents.google.com/patent/US20150175276A1/en ↑ Pleis, James. "Drone Operated Delivery Receptacle." U.S. Patent Application No. 15/289,295. https://patents.google.com/patent/US20170116568A1/en ↑ van Dyke. J. (2016). Unattended Delivery Drop Box. Chicago (US). https://patents.google.com/patent/US20170091710A1/en ↑ 8.0 8.1 Amazon.(2015, November 29). Amazon Prime Air [Youtube]. Retrieved from https://www.youtube.com/watch?v=MXo_d6tNWuY ↑ 9.0 9.1 9.2 9.3 9.4 Welch, Adrienne (2015). "A cost-benefit analysis of Amazon Prime Air". University of Tennessee at Chattanooga. Retrieved from https://scholar.utc.edu/cgi/viewcontent.cgi?referer=https://www.google.nl/&httpsredir=1&article=1051&context=honors-theses ↑ 10.0 10.1 Clarke, R. “The regulation of civilian drones impacts on behavioral privacy”, Elsevier (2014). Retrieved from https://www.sciencedirect.com/journal/computer-law-and-security-review ↑ 11.0 11.1 Besluit omgevingsrecht. (2010, March 25). Consulted on March 14 2018, from http://wetten.overheid.nl/BWBR0027464/2018-01-01#BijlageII ↑ Wet en Regelgeving. (1991, August 29). Consulted on March 14 2018, from http://wetten.overheid.nl/BWBR0005181/2018-01-01 ↑ DHL Packaging material and tips. Retrieved from https://www.dhl.de/en/privatkunden/pakete-versenden/verpacken.html ↑ 14.0 14.1 Young, L.A. “A Multi-Modality Mobility Concept for a Small Package Delivery UAV”. Retrieved from https://vtol.org/store/product/a-multimodality-mobility-concept-for-a-small-package-delivery-uav-11868.cfm ↑ 15.0 15.1 Technical Univesity Eindhoven 0LAUK0 Group 20 2016-2017 Quartile 3. Retrieved from http://cstwiki.wtb.tue.nl/index.php?title=PRE2016_3_Groep20 ↑ Ehsan Abdi, Hamid Soofi Mariv, Azade Deljouei & Hormoz Sohrabi(2014) Accuracy and precision of consumer-grade GPS positioning in an urban green space environment, Forest Science and Technology,10:3, 141-147, DOI. Retrieved from https://www.tandfonline.com/doi/pdf/10.1080/21580103.2014.887041?needAccess=true ↑ Technical University Eindhoven 0LAUK0 Group 10 2017-2018 Quartile 3. Retrieved from http://cstwiki.wtb.tue.nl/index.php?title=PRE2017_3_Groep10 ↑ 18.0 18.1 Burgelijk wetboek Boek 6. (2017, January 9). Consulted on March 22 2018, from http://wetten.overheid.nl/BWBR0005289/2017-09-01#Boek6_Titeldeel1_Afdeling3 Retrieved from "http://cstwiki.wtb.tue.nl/index.php?title=PRE2017_3_Groep11"	cc/2022-05/en_middle_0076.json.gz/line40
__label__wiki	0.941295	0.941295	Finally, Tinubu hints to run for Presidency The national leader of the All Progressives Congress (APC), Senator Bola Ahmed Tinubu, has finally confirmed the swirling rumours of his 2023 presidential ambition by seeking the support of one of the founding members of the Arewa Consultative Forum and elder statesman, Alhaji Tanko Yakasai. However, a leaked manifesto of Tinubu surfaced online recently, where several groups across the nation have been campaigning on his behalf while posters and billboards of the APC national leader are in major cities in Lagos State and across the country. Confirming Tinubu’s 2023 ambition, the elder statesman, Yakasai revealed to Saturday PUNCH that the ex-governor of Lagos was at his Abuja residence to solicit his support for the next general elections. Tinubu had last Wednesday visited the elder statesman at his Abuja residence. Speaking on the APC leader’s visit, the elder statesman said, “He (Tinubu) just came to visit me but actually I have two of them (presidential aspirants) that I have earmarked right from the beginning and I made a vow that anyone of them who came to ask for my support first is the person I would support. Tinubu is the first person.” 96-year-old Yakasai added, “He (Tinubu) said would be contesting for President in 2023 and he asked for my support.” Yakasai, however, said he didn’t disclose to Tinubu, during the visit, that he would support his ambition. He also said that interested aspirants must first scale the hurdles of primary elections in their various political parties “then we will begin to compare them.” When asked whether he planned to join the ruling party after Tinubu’s visit, Yakassai said, “I don’t want to join any (political) party but I can support a candidate of my choice. I have said it way back in 1951 that I will not be a party member but I will support a candidate of my choice.” Tags: Hints Presidency Run Tinubu Previous: EXPOSED ! KWAM 1, Best Friend In Cold War Over New Wife Next: Fire Guts Lafenwa Market In Abeokuta	cc/2022-05/en_middle_0076.json.gz/line44
__label__cc	0.650395	0.349605	Erik Roberson eroberson@uabmc.edu eroberson@uab.edu Professor (P), Neurology , School of Medicine Director/ UAB Center for Neurodegeneration & Experimental Therapeutics, Neurology , School of Medicine Director/ UAB Alzheimer Disease Center, Neurology , School of Medicine Associate Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center Associate Scientist (C), Neurodegeneration and Experimental Therapeutics (CNET) , Neurology Associate Scientist (C), Alzheimer's Disease Center , Neurology Scientist (C), Multiple Sclerosis Center , Neurology Associate Scientist (C), Evelyn F. McKnight Brain Institute , Neurology Associate Scientist (C), Center for Glial Biology in Medicine , Academic Joint Departments Professor (S), Neurobiology , Academic Joint Departments Dr. Roberson is a neurologist and neuroscientist whose research is focused on age-related neurodegenerative disorders. He received his A.B. with highest honors from Princeton University, then earned his Ph.D in neuroscience and M.D. with high honors at Baylor College of Medicine where he studied molecular mechanisms of learning and memory. He completed a residency in neurology at the University of California San Francisco, where he also served as Chief Resident in Neurology. After residency, he completed a clinical fellowship in behavioral neurology at UCSF and resumed basic research at the Gladstone Institute of Neurological Disease. He joined the faculty at UAB in 2008. Dr. Roberson's laboratory investigates mechanisms and therapeutic approaches to Alzheimer's disease and frontotemporal dementia, and he directs the Center for Neurodegeneration and Experimental Therapeutics. He is also active in clinical research and patient care. He directs the UAB Alzheimer’s Disease Center, leads clinical trials, and cares for patients with memory disorders and dementia at the Kirklin Clinic. 2021 Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization. Scientific Reports. 11. 2021 2021 Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice. Neurobiology of Disease. 158. 2021 2021 A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease. Nature Medicine. 27:1187-1196. 2021 2021 Dynamic Amyloid PET: Relationships to Flortaucipir Tau PET Measures.. Journal of Nuclear Medicine. 2021 2021 Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration. Neurology. 96:e2296-e2312. 2021 2021 Erratum: ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects (The Journal of clinical investigation (2014) 124 3 (981-999) PII: 149564). Journal of Clinical Investigation. 131. 2021 2021 Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42. Alzheimer's and Dementia. 17:475-488. 2021 2021 Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy. PLoS Genetics. 17. 2021 2021 Brain volumetric deficits in MAPT mutation carriers: a multisite study. Annals of Clinical and Translational Neurology. 8:95-110. 2021 2021 Development of a multi-component intervention to promote participation of Black and Latinx individuals in biomedical research.. Journal of Clinical and Translational Science. 5:e134. 2021 2021 Racial Differences in Alzheimer's Disease Specialist Encounters Are Associated with Usage of Molecular Imaging and Dementia Medications: An Enterprise-Wide Analysis Using i2b2. Journal of Alzheimer's Disease. 79:543-557. 2021 2021 Templated α-synuclein inclusion formation is independent of endogenous tau. eNeuro. 8. 2021 2020 Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients. Annals of Clinical and Translational Neurology. 7:2433-2449. 2020 2020 Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications. 11. 2020 2020 Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease. Nature Communications. 11. 2020 2020 Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability. eLife. 9:1-25. 2020 2020 Revised Self-Monitoring Scale: A potential endpoint for frontotemporal dementia clinical trials. Neurology. 94:e2384-e2395. 2020 2020 Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases. American Journal of Human Genetics. 106:632-645. 2020 2020 A REDCap-based model for electronic consent (eConsent): Moving toward a more personalized consent.. Journal of Clinical and Translational Science. 4:345-353. 2020 2020 Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability 2020 2020 Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration. Nature Medicine. 26:387-397. 2020 2020 Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. Journal of Experimental Medicine. 217. 2020 2020 A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity. Neurobiology of Disease. 134. 2020 2020 Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients with Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial. JAMA Neurology. 77:215-224. 2020 2020 β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science Translational Medicine. 12. 2020 2020 Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration. Alzheimer's and Dementia. 16:91-105. 2020 2020 Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimer's and Dementia. 16:11-21. 2020 2020 Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.. Alzheimer's and Dementia. 16:11-21. 2020 2020 Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration. Alzheimer's and Dementia. 16:49-59. 2020 2020 Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort. Alzheimer's and Dementia. 16:60-70. 2020 2020 Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases. Alzheimer's and Dementia. 16:118-130. 2020 2020 Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration. Alzheimer's and Dementia. 16:37-48. 2020 2020 Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium. Alzheimer's and Dementia. 16:79-90. 2020 2020 Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium. Alzheimer's and Dementia. 16:106-117. 2020 2019 Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. Acta Neuropathologica Communications. 7. 2019 2019 A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data. Scientific Reports. 9. 2019 2019 A blood-based signature of cerebrospinal fluid Aβ 1–42 status. Scientific Reports. 9. 2019 2019 Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies 2019 2019 Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways. Scientific Reports. 9. 2019 2019 Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification. Scientific Reports. 9. 2019 2019 Non-coding variability at the APOE locus contributes to the Alzheimer’s risk. Nature Communications. 10. 2019 2019 Nonlinear Z-score modeling for improved detection of cognitive abnormality 2019 2019 Predicting Alzheimer’s disease progression using multi-modal deep learning approach. Scientific Reports. 9. 2019 2019 Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics. Scientific Reports. 9. 2019 2019 The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory. Nature Communications. 10. 2019 2019 Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain. Frontiers in Neurology. 10. 2019 2019 Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. 104:458-470.e5. 2019 2019 Non-Coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases 2019 2019 Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2). Nature Genetics. 51:1423-1424. 2019 2019 Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer’s Dementia. Molecular Neurobiology. 56:4916-4924. 2019 2019 Biomarker Localization, Analysis, Visualization, Extraction, and Registration (BLAzER) Workflow for Research and Clinical Brain PET Applications 2019 2019 Medical decision-making in progressive supranuclear palsy: A comparison to other neurodegenerative disorders. Parkinsonism and Related Disorders. 61:77-81. 2019 2019 Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice. Neurobiology of Disease. 124:152-162. 2019 2019 Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51:414-430. 2019 2019 Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations. Parkinsonism and Related Disorders. 60:138-145. 2019 2019 Biomarker Localization, Analysis, Visualization, Extraction, and Registration (BLAzER) Methodology for Research and Clinical Brain PET Applications. Journal of Alzheimer's Disease. 70:1241-1257. 2019 2019 Genome sequencing for early-onset or atypical dementia: High diagnostic yield and frequent observation of multiple contributory alleles. Cold Spring Harbor molecular case studies. 5. 2019 2018 Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states. Scientific Reports. 8. 2018 2018 Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease. Scientific Reports. 8. 2018 2018 Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images. Scientific Reports. 8. 2018 2018 Sex-specific genetic predictors of Alzheimer’s disease biomarkers. Acta Neuropathologica. 136:857-872. 2018 2018 Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference. Nature Communications. 9. 2018 2018 Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau. JAMA Neurology. 75:989-998. 2018 2018 Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency. Molecular Neurodegeneration. 13. 2018 2018 Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging. Trends in Neurosciences. 41:349-359. 2018 2018 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.. Anesthesiology. 128:728-744. 2018 2018 Progranulin gene therapy improves lysosomal dysfunction and microglial pathology associated with frontotemporal dementia and neuronal ceroid lipofuscinosis 2018 2018 Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease 2018 2017 Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features. Scientific Reports. 7. 2017 2017 Genetic influences on cognition in progressive supranuclear palsy. Movement Disorders. 32:1764-1771. 2017 2017 Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty. Scientific Reports. 7. 2017 2017 18F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study. Annals of Neurology. 82:622-634. 2017 2017 Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. 49:1373-1384. 2017 2017 Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's and Dementia. 13:727-738. 2017 2017 Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects. Journal of Neural Transmission. 124:721-738. 2017 2017 Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease. JAMA Neurology. 74:557-566. 2017 2017 Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia 2017 2017 Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease. Scientific Reports. 7. 2017 2017 Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease. Neurobiology of Aging. 49:216.e7. 2017 2016 Incidence and impact of subclinical epileptiform activity in Alzheimer's disease. Annals of Neurology. 80:858-870. 2016 2016 Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale. Movement Disorders. 31:1574-1577. 2016 2016 Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy. Parkinsonism and Related Disorders. 28:29-35. 2016 2016 Predicting disease progression in progressive supranuclear palsy in multicenter clinical trials. Parkinsonism and Related Disorders. 28:41-48. 2016 2016 Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test. Genes, Brain and Behavior. 15:588-603. 2016 2016 Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. Nature Communications. 7. 2016 2016 Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults. JAMA Neurology. 73:721-732. 2016 2016 Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiology of Aging. 41:200.e13-200.e20. 2016 2016 Power calculations and placebo effect for future clinical trials in progressive supranuclear palsy. Movement Disorders. 31:742-747. 2016 2016 Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci. PLoS ONE. 11. 2016 2016 A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry. 21:108-117. 2016 2015 Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimer's and Dementia. 11:1439-1451. 2015 2015 The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity. Human Molecular Genetics. 24:6667-6674. 2015 2015 Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease 2015 2015 Association of long runs of homozygosity with Alzheimer disease among African American individuals. JAMA Neurology. 72:1313-1323. 2015 2015 O3‐06‐01: Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease. Alzheimer's and Dementia. 11. 2015 2015 Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study. PLoS Medicine. 12. 2015 2015 Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nature Communications. 6. 2015 2015 Effects of exercise on progranulin levels and gliosis in progranulin-insufficient mice. eNeuro. 2. 2015 2015 DNA methylation slows effects of C9orf72 mutations. Neurology. 84:1616-1617. 2015 2015 Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer’s disease 2015 2015 Rarity of the alzheimer disease-protective APP A673T variant in the United States. JAMA Neurology. 72:209-216. 2015 2015 Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 125:591-599. 2015 2015 Noradrenergic dysfunction in Alzheimer's disease. Frontiers in Neuroscience. 9. 2015 2014 AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (bret) assays for identification of Tau-Fyn sh3 interaction inhibitors for Alzheimer disease. Journal of Biomolecular Screening. 19:1338-1349. 2014 2014 Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia 2014 2014 MicroRNA-124 modulates social behavior in frontotemporal dementia. Nature Medicine. 20:1381-1383. 2014 2014 Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: A genome-wide association study. JAMA Neurology. 71:1394-1404. 2014 2014 Seizure resistance without parkinsonism in aged mice after tau reduction. Neurobiology of Aging. 35:2617-2624. 2014 2014 ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. Journal of Clinical Investigation. 124:981-999. 2014 2014 Davunetide in patients with progressive supranuclear palsy: A randomised, double-blind, placebo-controlled phase 2/3 trial. Lancet Neurology. 13:676-685. 2014 2014 Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. Journal of Experimental Medicine. 211:1937-1945. 2014 2014 The dendritic hypothesis for Alzheimer's disease pathophysiology. Brain Research Bulletin. 103:18-28. 2014 2013 Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. Annals of Internal Medicine. 158:5352-5362. 2013 2013 Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in alzheimer's disease. Journal of Cell Science. 126:1278-1286. 2013 2013 Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development. Alzheimer's and Dementia. 9:176-188. 2013 2013 The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier). Alzheimer's and Dementia. 9:189-198. 2013 2012 Challenges and opportunities for characterizing cognitive aging across species. Frontiers in Aging Neuroscience. 4. 2012 2012 Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nature Genetics. 44:1349-1354. 2012 2012 Mouse models of frontotemporal dementia. Annals of Neurology. 72:837-849. 2012 2012 Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits. PLoS ONE. 7. 2012 2012 Novel late-onset Alzheimer disease loci variants associate with brain gene expression.. Neurology. 79:221-228. 2012 2012 Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants. PLoS Genetics. 8:e1002707-e1002707. 2012 2012 Mouse models of Alzheimer's disease. Brain Research Bulletin. 88:3-12. 2012 2012 Evidence for a role of the rare p.A152T variant in mapt in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21:3500-3512. 2012 2011 Geriatric epilepsy: Research and clinical directions for the future. Epilepsy and Behavior. 22:103-111. 2011 2011 Contemporary approaches to Alzheimer's disease and frontotemporal dementia.. Methods in Molecular Biology. 670:1-9. 2011 2011 Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling.. Methods in Molecular Biology. 670:245-262. 2011 2011 Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43:436-443. 2011 2011 Amyloid-β/fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of alzheimer's disease 2011 2011 Contemporary approaches to Alzheimer's disease and frontotemporal dementia. Methods in Molecular Biology. 670:1-9. 2011 2011 Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: Depletion of calcium-dependent proteins and inhibitory hippocampal remodeling. Methods in Molecular Biology. 670:245-262. 2011 2011 Step-by-step in situ hybridization method for localizing gene expression changes in the brain. Methods in Molecular Biology. 670:207-230. 2011 2010 Beyond diagnosis: What biomarkers are teaching us about the "bio"logy of Alzheimer disease. Annals of Neurology. 67:283-285. 2010 2009 Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease 2009 2008 Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease 2008 2008 Abnormal social behaviors in mice lacking Fgf17. Genes, Brain and Behavior. 7:344-354. 2008 2007 Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease. Neuron. 55:697-711. 2007 2007 Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science. 316:750-754. 2007 2006 100 Years and counting: Prospects for defeating Alzheimer's disease. Science. 314:781-784. 2006 2006 Frontotemporal demetia. Current Neurology and Neuroscience Reports. 6:481-489. 2006 2006 Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease. Neuron. 51:703-714. 2006 2005 Frontotemporal dementia progresses to death faster than Alzheimer disease. Neurology. 65:719-725. 2005 2005 Frontotemporal lobar degeneration: Demographic characteristics of 353 patients. Archives of Neurology. 62:925-930. 2005 2003 Polyneuropathy following gastric bypass surgery [6]. American Journal of Medicine. 115:679-680. 2003 2001 Memory-forming chemical reactions. Reviews in the Neurosciences. 12:41-50. 2001 2000 MAPK regulation of gene expression in the central nervous system. Acta Neurobiologiae Experimentalis. 60:377-394. 2000 1999 A biochemical blueprint for long-term memory. Learning and Memory. 6:381-388. 1999 1999 The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus 1999 1998 Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation 1998 1998 A role for superoxide in protein kinase C activation and induction of long-term potentiation. Journal of Biological Chemistry. 273:4516-4522. 1998 1998 Protected-site phosphorylation of protein kinase C in hippocampal long- term potentiation. Journal of Neurochemistry. 71:1075-1085. 1998 1996 Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation. Journal of Biological Chemistry. 271:30436-30441. 1996 1996 A biochemist's view of long-term potentiation. Learning and Memory. 3:1-24. 1996 1995 Regulation of adenylyl cyclase in LTP. Behavioral and Brain Sciences. 18:485-485. 1995 1992 Ca2+-induced persistent protein kinase C activation in rat hippocampal homogenates 1992 1988 Identification of an insulin-like factor in astrocyte conditioned medium. Brain Research. 460:60-67. 1988 Aberrant regulation of a poison exon caused by a non-coding variant in Scn1a-associated epileptic encephalopathy 2017 Clinical Neuroscience 2017 2011 Alzheimer's Disease and Frontotemporal Dementia 2011 2017 Frontotemporal Dementia. 141-175. 2017 2016 Animal models of dementia. 77-93. 2016 2011 Preface 2011 2009 Animal models of dementia. 131-141. 2009 2007 Molecular aspects of memory dysfunction in Alzheimer’s disease. 245-293. 2007 Alzheimer's disease, frontotemporal dementia, and related disorders ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) - Clinical Core awarded by MAYO CLINIC Abnormal Late Endosomal Trafficking in Frontotemporal Dementia due to Progranulin Mutations awarded by National Institute on Aging/NIH/DHHS Advancing Research and Treatment for Frontotemporal Lobar Degeneration [ARTFL]: Research Project 1 & 2 awarded by University of California, San Francisco BIN1 and Tau Interactions Regulating Neuronal Calcium awarded by Alzheimer's Association BIN1, Interneuron Activity, and Network Dysfunction in Alzheimer Disease awarded by National Institute on Aging/NIH/DHHS Causes, Treatment, and Prevention of Corticobasal Degeneration awarded by University of California, San Francisco Characterizing an Inducible Model for the Protective Effects of Tau Reduction awarded by American Health Assistance Foundation Circadian Changes in Network Excitability and Alzheimer Disease Pathogenesis awarded by National Institute on Aging/NIH/DHHS Consortium for Frontotemporal Dementia Research awarded by University of California, San Francisco Developing Inhibitors Of Tau-SH3 Interactions As Treatments For Alzheimer's Disease And Hyperexcitability awarded by WESTON BRAIN INSTITUTE Development of Inhibitors of the Tau-Fyn Interaction For the Treatment of Alzheimer's Disease awarded by BRIGHT FOCUS FOUNDATION Epileptiform Activity in Neurodegenerative Disease awarded by STEPHEN BECHTEL JR. FUND Imaging Dementia - Evidence for Amyloid Scanning (IDEAS) Study: A Coverage with Evidence Development Longitudinal Cohort Study awarded by American College of Radiology Investigating the Impact of Cognition on Functional Ability in PSP awarded by CUREPSP Mechanisms for Tau Involvement in Alzheimer's Disease awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS Mechanisms for the Benefit of Tau Reduction in Alzheimer Disease Models awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS Mechanisms of Frontotemporal Dementia Like Behavior in Progranulin Deficient Mice awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS Molecular Mechanisms of Aging-Related Neuronal Dysfunction in Progranulin-Insufficient Mice awarded by American Federation for Aging Research Optimizing Progranulin Gene Therapy for Frontotemporal Dementia awarded by THE BLUEFIELD PROJECT TO CURE FRONTOTEMPORAL DEMENTIA Private Grant awarded by ALLON THERAPEUTICS Private Grant awarded by AVID RADIOPHARMACEUTICALS Private Grant awarded by C2N DIAGNOSTICS, LLC Private Grant awarded by ALECTOR, INC. Private Grant awarded by BIOGEN IDEC, INC. Targeting the Tau-Fyn Interaction in Alzheimer's Disease awarded by WESTON BRAIN INSTITUTE Tau and Fyn in Alzheimer's Disease Pathogenesis awarded by ALZHEIMER'S OF CENTRAL ALABAMA Tau and Glutamatergic Synapses in Frontotemporal Dementia awarded by National Institute on Aging/NIH/DHHS Tau-Fyn Interaction and Alzheimer's Disease awarded by National Institute on Aging/NIH/DHHS The Cause and Effect of Reduced ß-glucocerebrosidase Activity in the Setting of Progranulin Deficiency awarded by National Institute on Aging/NIH/DHHS The Frontotemporal Lobar Degeneration Clinical Research Consortium awarded by University of California, San Francisco The Progranulin C-Terminal Domain and AAV-Progranulin Gene Therapy for Frontotemporal Dementia awarded by National Institute on Aging/NIH/DHHS The Role of Tau in Neurodegeneration awarded by STEPHEN BECHTEL JR. FUND Therapeutic Strategies in Mouse Models of FTD Due to Progranulin Insufficiency awarded by THE BLUEFIELD PROJECT TO CURE FRONTOTEMPORAL DEMENTIA Therapeutic Strategies in Mouse Models of FTD Due to Progranulin Insufficiency (Consortium for Frontotemporal Dementia Research) awarded by THE BLUEFIELD PROJECT TO CURE FRONTOTEMPORAL DEMENTIA Toward Therapeutic Approaches to TREM2-R47H in Alzheimer's Disease awarded by Alzheimer's Drug Discovery Foundation UAB Alzheimer's Disease Research Center awarded by National Institute on Aging/NIH/DHHS UAB Alzheimer's Disease Research Center - Admin Core awarded by NIH - National Institutes of Health/DHHS Validation of Online Methods to Predict and Monitor Cognitive Decline awarded by University of California, San Francisco Weston Advisor Fellowship awarded by WESTON BRAIN INSTITUTE A Randomized, Double-Blind, Placebo-Controlled, Two Dose-Arm, Parallel Study of the Safety and Effectiveness of Immune Globulin Intravenous (Human), 10% (IGIV, 10%) for the Treatment of Mild-To-Moderate Alzheimer's Disease awarded by University of California, San Diego Alpha-Synuclein Aggregate Induced Synapse Loss is a Pathological Event contributing to Lewy Body Dementias awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS Alzehimer's Disease Neuroimaging Initiative (ADNI) awarded by University of California, San Diego Alzheimer's Disease Cooperative Study - A4 Study awarded by University of Southern California Alzheimer's Disease Neuroimaging Initiative 2 (ADNI2) awarded by University of Southern California Amyloid Imaging, VMCI, and Analysis for ADNI awarded by University of California, San Diego Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4 Study) awarded by University of California, San Diego Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4 Study) awarded by University of Southern California Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Open-Label Extension Study awarded by University of Southern California Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease(A4 Study) awarded by University of Southern California Circadian Dysfunction and GSK3 in Neurodegenerative Disease awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS Circadian Dysfunction and Neurodegenerative Disease awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS Consequences of Noradrenergic Degeneration in the Novel TgF344-AD Rat Model awarded by National Institute on Aging/NIH/DHHS Day-Night Differences in Hippocampal Neurophysiology in Alzheimer's Disease awarded by National Institute on Aging/NIH/DHHS Functional Change in Mild Cognitive Impairment awarded by National Institute on Aging/NIH/DHHS Global Alzheimer’s Platform Trial-Ready Cohort for Preclinical/Prodromal Alzheimer’s Disease awarded by University of Southern California Identifying Therapeutic Targets That Confer Synaptic Resilience to Alzheimer's Disease awarded by National Institute on Aging/NIH/DHHS Improving Family Quality of Life Through Training to Reduce Care-Resistant Behaviors by People with Alzheimer Dementia and Traumatic Brain Injury awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - The LEARN Study A Companion Observational Study to Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Trial awarded by University of California, San Diego Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study: A Companion Observational Study to Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Trial awarded by University of Southern California Preclinical Test for the Efficacy of Adrenergic Agents in Treatment of AD awarded by National Institute on Aging/NIH/DHHS Private Grant awarded by TRANSITION THERAPEUTICS INC. Private Grant awarded by EISAI, INC. Private Grant awarded by H. LUNDBECK A/S Private Grant awarded by NEURIM PHARMACEUTICALS Private Grant awarded by BIOGEN MA INC Reducing Tau as a Therapeutic Strategy for Improving Cognitive Dysfunction in Parkinson's Disease awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY Role of Adolescent Stress in Postpartum Mood and Cognition awarded by National Institute of Mental Health/NIH/DHHS TREM2-Endogenous Ligand Interactions in Alzheimer Disease awarded by National Institute on Aging/NIH/DHHS Targeting PRMT5 in Cancer Initiating Cells as a New Therapy for Glioblastoma awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS Targeting Rho Kinases for Alzheimer's Disease Therapeutics awarded by National Institute on Aging/NIH/DHHS Tau PET Imaging for the USC Alzheimer's Therapeutic Research Institute (USC ATRI) A4 Trial (“A4 TAU”) awarded by University of Southern California Training Program in the Neurobiology of Cognition and Cognitive Disorders awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS UAB Training Program in Neuroscience awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS GBS700 - Molec Neurodegen (Spring Term 2014) GBS790 - Clinical Eval of Cogn Disorder (Spring Term 2012) GBS793 - Alzheimer & Frontotemp Dem (Fall Term 2011) GBS793 - Alzheimer & Frontotemp Dem (Spring Term 2012) GBS793 - Alzheimer JC (Fall Term 2013) GBS793 - Alzheimer JC (Spring Term 2013) GBS793 - JC- Alzheimer & Dementia (Spring Term 2019) GBSC739 - Training Grant Course (Spring Term 2019) Baylor College of Medicine, Internship UCSF Medical Center Neurology, Residency UCSF Medical Center, Postdoctoral Fellowship Doctor of Medicine, Baylor College of Medicine 1999 Doctor of Philosophy in Neuroscience, Baylor College of Medicine 1997	cc/2022-05/en_middle_0076.json.gz/line49
__label__wiki	0.528977	0.528977	In this section we illustrate the long-in-the-making, but just recently "exploded" war on fat. This is the next chapter of the most profitable business enterprise the world ever undertook: public health activism. Inert, indifferent and defeated, people continue to allow "public health" to control their lives more every day. Has the West surrendered individualism and freedom in favour of paternalism and statistical frauds in exchange for the vague perception of "better" health? Commentaries and articles logged up to August 20th, 2007. Later commentaries on the frauds on fat and demonisation of food can be found in the current portal system, using the internal search engine. Straightening Up Eaters (2007) Category: Static May 14 - Do these pants make my pancreas look big?- Never let it be said that those cashing in on the "obesity epidemic" lack creativity in covering all angles in their quest to shakedown a panic-stricken public. So you think you are safe from premature heart attack and diabetes, all you slim and trim people? Hah! Think again. According to some doctors you could be just as prone to the pathologies that strike down your fat brethren. Your fat, however, is inside your svelte frame, busily smothering the vital organs. "Being thin doesn't automatically mean you're not fat" and "just because someone is lean doesn't make them immune to diabetes or other risk factors for heart disease," is the message from these grifters who admit that they don't actually know whether interior fat poses health problems. They "suspect" it does and "theorize" that fat enveloping interior organs "might" be sending the body mistaken chemical signals to store fat inside organs like the liver or pancreas. Very much like the concept that "smoking kills no matter what" forerunner of all frauds, here is the "you are fat even even if you are thin" concept. What to do? Turn it all over to the experts. Stop smoking. You quit. Stop eating. You become a vegetarian. Exercise. You jog till you drop. The bottom line to these hypotheses without evidence is that "bad" eating habits, the bête noire of the anti-fat crusaders, must be eradicated even for those who are not overweight. Junk the sugar, discard the fat and above all exercise, exercise. We all know, and perhaps unconsciously hate, those few, lucky people who can eat what they want and all that they want without gaining an ounce. There is no need to envy them anymore since they, just like the obviously overweight, are in need of the firm guidance that pours forth from the caring people who will make us fit no matter what it takes. May 10- From Germany but about England: cheese ads to children forbidden in England, and more coming for your own good! -No more cheese advertisement in children-oriented shows in England. Cheese is bad, destroys the body, makes you fat and lazy and "causes" disease. And there is far too much salt for children, anyway: take the word of the "experts", they know what they are saying. After years of relentless "studies", our "expert" heroes have finally labelled cheese as junk food. At the same time Homer Simpson will have to be shown far less, because he gives "incorrect" dietary advice to his kids. On their side, the cheese manufacturers are showing the expected butt-kissing attitude already adopted by the tobacco industry, but with an even more 21st century twist. They make, in fact, the ultimate loser demand: equality under oppression. If cheese is bad for health, they argue, what to say about cheeseburgers and Coca-Cola, that are "really baaad" for you? Forbid that advertisement too! In the meantime, instead of suing the hell out of the "public health" crooks, shut down their industries in protest and create a political problem (before it's too late), the cheese manufacturer lobbies are writing a petition -- as the supply of toilet paper in the "public health" offices is worrisomely low for the protection of the environment. In the meantime, God forbid that every idiot is not given exactly what he deserves, and that the holy hand of "public health" does not bestow its wrath on Coke and hamburgers to maintain absolute justice. Finally, the British "experts" "recommend" the prohibition of adult-oriented cheese advertisement to make anti-cheese campaigns more effective. May 3- Haven't we seen this before? - Overweight workers cost their bosses more in injury claims than their lean colleagues, suggests a study that found the heaviest employees had twice the rate of workers' compensation claims as their fit co-workers. Just as anti-tobacco "suggested" that smokers cost their employers more than normal so the overweight are now being tarred as economic negatives. In both cases proof is not required to demonize whole classes of people whose only sin is not to worship at the altars of health. In reality smokers and the overweight don't cost society any more dollars than do those who don't smoke or fall into the proper weight limit as determined by behavior control activists. As they did with smoking civil libertarians are weakly advising employers not to "overreact" with discriminatory policies rather than honing in on the junk science that reduces people to a grid of numbers. The scandal is not fat or smoking workers but the "science" that labels them so based on statistical manipulation that never proves but only suggests. May 1 - 'If you're fat you most probably won't get that job' - Many if not most readers of this site will recall the days when smokers were regarded as people, not pathetic, skanky addicts whose very presence poisoned entire communities at a single puff. The people who brought us hatred of smokers continue to work their foul spell on the overweight. First, "studies" spring up in the media like mushrooms after a rain telling everyone how obesity is linked with various diseases and how employers should suspect lower productivity and fear future healthcare costs (a particularly compelling worry in the US where there is no national health system). Now -bingo! Surveys show that employers are less inclined to hire the overweight. There's probably nothing new about that - attractive, fit-looking people have always had an advantage in our culture. But in the current climate, it wouldn't be a surprise to find that employers are inclined to be more discriminatory than ever before. The new twist now is to look on being overweight as a "disability" in order to protect them from discrimination. Pretty diabolical-we're deeply stigmatizing people while simultaneously encouraging them to think of themselves as victims needing "help" from external programs. So does this mean that EVERYTHING which "could lead" to a chronic disease should finally be regarded as a disability? With fat, we're making a "disability" out of something which is, at least to a large extend, simply an instance of normal human variation. We're pathologizing another aspect of life for purposes that could include both exploitation of the system by the "disabled" person, and exclusion or "special" treatment by government and institutions. April 24 -Perverting the language - The health establishment purposefully corrupts the language as a tactic to further its control over the population. Epidemic no longer refers to a terrible outbreak of infectious disease but is unethically used to describe voluntary behaviors such as smoking and eating. Addiction has been watered down to include smoking, shopping, gambling as well as other behaviors that used to be described as habits. "Proof" quite some time ago joined the words that Big Health perverted for its own ends. "Scientists prove that salty diet costs lives" screams the headline in the Times Online introducing a story about salt consumption. Within not only is there no "proof" but a close reading provides evidence that the researchers, along with the media, have completely abandoned the epidemiological standards that should govern research such as this. People who ate less salty food were found to have a 25 per cent lower risk of cardiac arrest or stroke, and a 20 per cent lower risk of premature death. Add a zero to these percentages and this study would have warranted a news story. Ethical epidemiologists are looking for at least 200% (relative risk 3) as the base to justify concern or intervention. These puny percentages warrant nothing (especially when the data is gathered with questionnaires!), as the researchers well know and reporters covering these issues should know. The reporter, a Health Editor, no less, should have informed his readers that 20 and 25 per cent indicate... nothing. He does, however, midway down remark that the number of heart attacks and deaths supposedly caused by a salty diet are so small that they could have occurred by "chance." Considering that the researchers are rehashing previous studies conducted one and two decades ago a more pertinent analysis should focus on why old research is dubbed "proof" of anything. Obviously the researchers are cashing in on the obesity "epidemic", a fertile ground for profitable grants. The United Kingdom, like other countries, is badgering its citizens to shape up and behave themselves. Anti-salt messages there are becoming increasingly strident and this study will bolster the campaigns to alter consumption. Like studies regarding the supposed bad effects from smoking tobacco, the salt and diet studies have proven only that Big Health long ago forgot why it is supported by a highly taxed population. April 20 -Calling time out on the media's weight obsessions: you tell ‘em, Tyra - Former supermodel Tyra Banks has come out as an unlikely (or is it logical?) spokesperson for the idea that our obsession with people's weight is … nuts. As various countries "crack down" on excessiveness skinniness in runway models (there have indeed been several anorexic deaths), Tyra Banks got called "fat" by the media for flashing a bit more flesh than usual in a bikini. Now she's calling BS on the whole schizophrenic body image obsession. Take that, health Nazis. "… there are models right now dying on the runway and people are saying that people are too skinny; then suddenly there are these pictures of me and they're saying I'm too big. And never mind me, I didn't really want to focus on that, but look, even if I had been 200 pounds, would that make me ugly and disgusting? Because that's what they were saying I was. And, if they're saying that, they're saying that to every woman: and so many women are 200 pounds, so many do have that shape, so that means that you're telling those women they're ugly and disgusting.'" April 20 -Bacon causes lung disease - Busy junk "scientists" in the United States have found that eating bacon, as well as othercured meats, increases the risk of lung disease. This report from the British Broadcasting Corporation wisely omits any percentages attached to the alleged increased risk so we can rest assured that the relative risk falls well below the threshold of concern. If the "scientists" had found a 200% increased risk of lung disease from consuming cured meats we might concur with their call for "more studies." The "scientists" attempt to cover their bases by invoking the incantation that "smoking remains the single most significant cause of [lung disease]" but will undoubtedly ignite the ire of the anti-tobacco pressure groups by concluding that smoking, as well as lower class status, insufficient vitamin C intake and bad diet, could not account for the increased risk of lung disease for the cured meat consumption. Of course these days special interest benefactors, such as the Robert Wood Johnson Foundation, have expanded their anti-tobacco ideology to include a bevy of "anti" stances, especially where food is concerned. Having discovered the joys of behavior modification through anti-smoking propaganda the "anti" advocates are eager to increase control wherever hysteria roams. April 20 -Peril in the post trans fat world - Proving yet again that they are never satisfied, the behavior engineers, despite their successful campaign to demonize trans fat, are now singing the blues that the proletariat faces new, perhaps insurmountable, challenges in a trans-fat-free environment. The elimination of trans fat, dubbed "heart-damaging" and "artery clogger", although no actual evidence exists that this cooking material warrants such terms of opprobrium, leaves a void that is being filled by animal fats, such as butter or lard, or tropical oils such as palm or coconut oil. Oh, the horror! Coconut oil, for those who remember the genesis of the modern food policing effort, should ring a bell since it was the evil substance that food ideologues successfully removed from movie house popcorn. As for butter, could there be anything more insidious to good health? The "good" substitutes for trans fat, such as olive, canola or soy bean oil, are useless for cookies, pastries and pizza crusts. It's no coincidence that these foods top the list of "unhealthy food" deplored by the food police. "You need to find a replacement for a solid fat that doesn't have the health implications, and that's the tougher battle," says Susan Borra of the International Food Information Council. "We are changing the entire fatty acid profile of the food supply, and we're not sure we know what it's going to look like at the other end." We are changing the food supply and we're not sure what will be the result. Could any statement be more arrogant and more reflective of the mantle of superiority with which the behavior engineers enwrap themselves? Historically any entity that proclaimed it was altering the food supply for entire populations with no concern as to the results wrought by its alteration would have been considered an enemy of the people and harshly curbed, if not eradicated. In our emasculated era, unfortunately, food supply manipulators are treated as indispensable, integral components of the community rather than noxious meddlers. This article provides propaganda space for the American Heart Association, an organization that lies deliberately and continuously about the effects of smoking, to dispense its nonsensical diet recommendations to a public that has fewer choices now than it had before the social engineers became a blight upon the nation. April 19 -Racial component of fat - Researchers investigating why Europeans are so fat have unearthed a racial component that undoubtedly will lead to many, fatter grants for further research. The numbers are quite precise: half of white Europeans carry a defective gene that causes a 30% increased risk of obesity while 16% percent carry two defective copies of the same gene, which carries a 70% risk of obesity. We'll accept the researchers word on the percentage of white Europeans saddled with the defective genes and concentrate solely on the risks they assign to carrying that disease. Even without looking at the data of the study one can easily figure that we are talking about inferred causality and not about a scientifically established one. "McCarthy notes that the function of FTO remains a mystery. It is unclear if people with the gene simply burn calories less efficiently or if they consume more food." These researchers know this, of course, but they also know how incompetent is the reportage of the media, even in something called NewScientist.com. Junk scientists also know how to follow the hype and capitalize on the political class's need to "do something." Obesity is the hottest "health threat" going, although tobacco research still rakes in the dough. Combining fat with racial differences is a two-fer in our obsessive culture where social engineers constantly seek to boil down human behavior into predictable equations that can be dealt with by an overbearing therapeutic health. As to the majority of Europeans who have these "defective" genes, no need to worry. The numbers cranked out mean nothing. But what is sinisterly meaningful is the approach - once again identical to anti-tobacco: people who are fat (like people who smoke) are defective. Next to what? Next to a defective ideology concerning itself with the "perfect, healthy man" who is compared with assorted computer models. We have been down that defective path before, haven't we?... And walking down that path with or without computers makes no difference. We discovered then that this is not the logical way to go and -- even less -- the human way to go. We have to discover it again -- because to err is human, but to persevere is diabolical. April 12 -Soft drink tax - Norway is poised to raise taxes on soft drinks and sweets. The country has a history of taxing "luxury" products such as alcohol and cigarettes and now is going after products that are considered "unhealthy." While refreshing to read a news story that veers off script by mentioning cigarettes and soft drinks in the same paragraph but labelling just the soft drinks as unhealthy, it is disturbing that governments throughout the world are basing policy decisions on pseudo "scientists" who crank out junk studies that are more hype than research. The government is keeping its cards close to its vest on how high the taxes will go and on what they will be imposed but the ubiquitous "activists" hope for at least a doubling of the tax rate. The activists also are clear on why taxes must be raised: "The problem is that we eat much too much sugar... too little fruit and vegetables, and too many processed foods like potato chips." As usual the operative speaks for the population at large, deciding with his use of the royal "we" what will be done with the taxpayers who pay his salary. The newspaper moves back on script as it reports that Norwegians are firmly behind the government's plan to raise taxes. Never before have there been so many people who want their taxes raised, at least according to those who live to bilk the public. April 12 -Salt, the new Plutonium - Who would have thought it? Apparently in Canada there are 15,000 dead bodies found each year, every last one of them done in by salt. The numbers come from the Center for Science in the Public Interest, the American shakedown organization that wants everyone everywhere to adopt its austere diet of self-denial. CSPI is not above lying to stir up hysteria while pressuring governments to crack down on the consumer. For some reason salt consumption is an inordinate concern of this group even though at the moment "research" has been exonerating salt after years of demonization. America may not produce any goods that people would like to buy these days but it sure is successful in peddling junk science throughout the world, no matter how fraudulent the claims. April 12 -Eat drink and be merry for dieting is no use - The experts for years have been hectoring us to loose weight since we are too damned fat. The message is relentless and accompanies the drumbeat of countless "studies" proclaiming that the industrialized nations are undergoing an epidemic of obesity. Governments have of course gotten in the act by re-defining obesity and heaviness so that more people fall into that category without having to gain a pound. Dieting has become a chronic condition for a huge swath of people. So what are to make of the latest research that seems to say "give up and pork up?" At least that is one message coming from junk science central, the University of California where "scientists" analyzed dozens of studies involving thousands of dieters. The university's conclusion? Dieting doesn't work. This is an odd message to proclaim during an epidemic of obesity and speculations on the university's motives are just that. One explanation is that the university is preparing to pave the path for the pharmaceutical industry to enter more aggressively the weight loss game. Just as those who successfully quit smoking are those who do so without using smoking cessation products those who lose weight and keep it off do so on their own using will power. Will power cannot be patented but weight loss aids can be. Pharmaceutical money is behind the studies that discovered an obesity epidemic just as pharmaceutical money financed "research" that discovered that smoking leads to all manner of illness and an early, inevitable death. Based on its behavior regarding tobacco, expect a flurry of studies recommending professional help and pharmaceutical aids to lose weight successfully. It worked with tobacco so why change a con job that brings lots of money to Big Drugs. April 5 -A breath of fresh air - Every day scads of health-related stories hit the newsprint and airwaves bringing the latest study to the public. These studies warn against newly-discovered risks or tout the benefits of a particular diet or a special regimen designed to promote longevity. Attentive readers and viewers over time often experience dejà vue. Haven't I heard this before, they ask themselves. Well, yes you have heard it before and sometimes you've heard some food or activity touted to the sky only to be damned later as suicidal. Wine bad, red wine good, carbs out, carbs in. What's a consumer to do? Listen to an actual expert whose job depends on results, not deceptive hypotheses. Speaking at an American College of Sports Medicine-sponsored health and fitness summit Wendy Repovich, an exercise physiologist, spoke of the health myths that mystify the public. Eggs, for instance, got a bad reputation because researchers, aware that the yolk contains the highest amount of cholesterol of any food, transformed that fact into a panic attack that frightened people away from a food that mankind had enjoyed for thousands of years. "Most people avoid eggs and probably if they have any kind of cardiovascular risk their physicians tell them to avoid eggs," Repovich said. "But really, there aren't a whole lot of studies that show that one or two eggs a day really make a difference to cholesterol levels." There are, however, a passel of studies, rendered into overwrought prose by our lazy press, that imply (but never prove) that eating eggs is asking for a heart attack. The sheer number gives the accounts a patina of authority that then becomes the Truth. Years later the same grant junkies crank out "studies" that exonerate the egg and the cycle is complete and ready to begin anew at an opportune time. Critics of this process, like Repovich, have far more credibility than the study-for-hire gang that produces results that please those who fund the research. Repovich, after all, makes her living advising sports franchises on how to keep the players healthy. Better still, just follow the wisdom of "moderation in all things" and ignore the hysterics of the media. April 2 -Trans fat in restaurants: "at least as serious as the menace of smoking" - The rhetoric of Public Health continues to exhibit the same cookie-cutter tediousness day after day, week after week, year after year. Another day, another crisis as bad or worse than smoking! This time it's trans-fats used in restaurants in Calgary, Canada, where the intrepid Dr. Brent Friesen, the Calgary Health Region's medical officer of health is gunning for promotion by playing the menace-of-the-moment game in the typically cynical fashion of his kind. But with Albertans starting to wonder about virus and bacteria-laden bone chips in the instruments used for internal medical exams (see story above) his talk of high standards of restaurant hygiene ring a little hollow: "We require them to have utensils in a sanitary condition, we're talking about a similar approach to preparing food -- there are alternatives to trans fats," he blathers. Does that mean that trans fats are unsanitary now? Maybe if it's low-priority, we could get talked into the notion that unsanitary in hospitals and clinics is the "new" sanitary? See, we can do it, too - play the bad faith topsy-turvy word spin game. Are these guys actually getting MEDICAL training these days, or are they all just appalling PR flaks in white coats? March 9 -Would Cass Elliot have a career today?- Readers of a certain age will certainly remember Cass Elliot, the full-throated singer from the ‘60s vocal group the Mamas and the Papas ("California Dreamin", etc). The header above links with a YouTube duet between Elliot and John Denver, two now long-dead figures from what, in retrospect, seems a much gentler and humane era. We digress. We've put the link up on FORCES not only to give our readers a break from the bad news, but to pose a question: as a fat woman, what would the wonderful Cass Elliot's chances be of having a career today? Would she be publicly harangued (as Barack Obama is over smoking) to lose weight in order to be a presentable or "suitable" performer for public consumption? Would she be told off by newspaper columnists for being a "bad role model"? Would there be discussions amongst the shriller "health advocates" about setting up government-imposed "standards" to regulate who can appear on federally-regulated airwaves on the basis of whether or not they appear "healthy"? Anyway, for the moment, sit back and enjoy a nice moment from free 1972 … March 7 -Fat good, fat bad, fat happy, fat sad - So now, for about 10 seconds, let's raise concerns about whether people are getting enough fat in their diets. Yes, notwithstanding the obesity epidemic that's engulfing the world and the threat of ravaging psychological devastation posed by thin runway models, it's time to focus on whether modern low fat diets are causing infertility. According to this ONE study from the United States, ovulation-related infertility goes up by a whopping 85 per cent if a woman eats five portions weekly of low-fat foods. Of course, it's being reported as if it were information that general readers could actually use, when it's not. One study simply does not give us anything that should be readily translated into "advice" for individuals about their specific habits and practices. But undeterred, one of the study's authors wades in to tell women what they should be eating. It's the fashionable thing to do, and the university's Public Relations office probably expects it: "Dr Chavarro said that his advice to women wanting to conceive would be to change their diet. ‘They should consider changing low-fat dairy foods for high-fat dairy foods; for instance, by swapping skimmed milk for whole milk and eating ice-cream, not low-fat yoghurt.' " In British coverage of the same story, another health professional gives the opposite advice: "I'm not convinced that there is any reason for women who are trying to conceive to alter their diet, unless they are obese," says Dr Richard Fleming. Two nations, two self-promoting "health experts," two quick quotes. Just another day hard day's work in the dubious business of "health promotion." March 9 -Champagne Charlie versus Ronald McDonald - Members of the British Royal family are not supposed to make overt political statements, but the heir to the throne has long been known for dabbling in "issues" . Maybe it's surprising that it's taken him so long to jump on the healthiest bandwagon. So now Charles has been "overheard" advocating a fast-food ban. A statement issued later assured us that the Prince "was keen to emphasise the need for children to enjoy the widest variety of food and not to eat any particular sort of food to excess." How touching and socially helpful. Never mind. How is the UK's republican movement doing these days, anyway? February 28 -This year, Girl Scout cookies have less trans fat - Here's Associated Press fleshing out a press release/publicity pamphlet from the Girl Scouts, acting under the assumption that this is somehow of compelling public interest. It is somewhat comforting to know that the internet, for all its faults, is offering us perspectives that can compete with the vacuity of "news" like this: "For much of the country, it's Girl Scout cookie time again. And this year, all those cookies, not just theThin Mints and a few others, will come nearly free of harmful trans fats." And, by the way, there is no scientific evidence that trans-fat is harmful - unless you believe in passive smoke! February 27 - Trans Fat Alternatives Also Risky - Cholesterol-raising trans fats may be disappearing from supermarket shelves and restaurants, but one type of fat taking their place may be no healthier, new research suggests. We have trans fat, which is BAD, saturated fat, which is GOOD, and now we have interesterified fat, which we just DON'T KNOW yet. Well, hey, if we "don't know" we can use this one and sue the companies later. Please note, the "bad", "good" or "don't know" isn't the object of the discussion. The object is when it will be appropriate to start the lawsuits. Public Health is not the issue here, the money is the true subject here, as this tobacco/fat lawyer's web site clearly shows. I-me-my-mine Roth Obesity activist February 21 - Savaging the Girl Scouts - "According to NAAO president MeMe Roth, campfires and merit badges only serve as window dressing for a baked-goods crime syndicate" Hey, I'm just an alleged lowly "Front for Big Tobacco." Can you imagine the scorn and embarrassment of being a "Front for Big Cookies?" What a sad - yet accurate - name for a narcissistic, self-centered, "Anti-Mentality" agenda opportunist: "MeMe Roth," president of the National Association Against Obesity (NAAO). "Oh, look at ME!" says MeMe, "I'm ‘Saving the Children!' What a noble thing I'm doing to gut finding for kids outdoor hiking activities on nature trails so we can save them!" Hilary Clinton - who launched the anti-obesity program Shape Up America with Dr. C. Everett Koop in December 1994 - once said it "takes a village" to raise children. MeMe and her Agenda-Afflicted cohorts would burn that village down to save it and the children who live there. Please note that anti-obesity is modeled after anti-tobacco. The Agenda-Afflicted have "progressed" from beating up on tobacco company executives to nailing grade school girls to the agenda-hype cross-of-scorn. A better example of how far this mindlessgrifting for Robert WoodJohnson Foundation grant bucks can go. So much for Democrats in the new 110th Congress having any pretense of honoring voters' mandate for change. It's business as usual with a particularly mean-spirited low-note in political mantras. February 12 -Forget Transfats! Step Away from that Copy of Seventeen Magazine!- Ronald Bailey of Reason magazine picks up on a new study which tells us that reading about diets is correlated with a higher rate of anorexia in teenage girls. Commenting on this and a Center for Science in the Public Interest call to ban food advertising to children, he comments: "Get it? Advertising makes you fat; diet information makes you anorexic," he comments. "Kind of a ‘damned if you do and damned if you don't' situation. It won't be long before the food and nutrition busybodies conclude that since information is toxic that we need to suspend the First Amendment. Of course, they'll do it "for the children." February 12 -The tyrannical doubletalk of the transfat bans - "Smokers have been relatively passive and have allowed the anti-smoking zealots to run roughshod over them. The question is whether those of us who wish to eat as we please will allow the food zealots to do the same. These people are cowards, and here's why: If Mayor Bloomberg and other food zealots think I'm eating too many trans fats, let them personally come and take fatty foods off my plate or remove them from my shopping cart. Since they don't have the guts to do that, they correctly deem it safer to use the brute force of the state to control what I eat." February 7 - One stiff study and this country boy is anybody's! - For the sake of public health, let's hope that Australian researcher Russell Keast is a bit more restrained in his personal behavior after a couple of drinks at the local pub than he is after a bracing bout of research - ‘cause after just one study published in the intriguingly named journal Appetite, he's a-lusting after prohibition! Yep, the most objective judge of his own work - and unashamed to say so, Keast assures us that his dire findings about the demon soda pop are "absolutely conclusive" and that government should consider banning the sale of caffeinated soft drinks to under-18s. Listen to the modesty, the restraint - after the inebriation of just one study (his own, of course): "He said banning the drinks' sale to children under the age of 18, in the same way alcohol was banned, could be one approach for governments to explore. ‘I think if that's a regulatory approach, that sort of thing should maybe be considered. I don't know what the best options are, how you would go about such things.'" Of course, he wouldn't know about stuff like that. Just a simple outback public health researcher on his first trip to the big, wicked city. January 29 - Cheese to join olive oil and raisins on British kids' TV ad ban - Cheese is junk food! That's the message from British regulators as they decide to ban its advertisement during children's viewing hours, hypothesizing a larger-than-average portion size to bolster their argument of "danger". Cheese joins a list of other advertising-banned foods which includes, incredibly, sultanas, raisins, olive oil and various nuts, as well as a variety of pre-packaged snacks. A National Farmers' Union spokesman described the latest ruling as "mad" and "absurd", but the industry lobby is unlikely to put off the new breed of totalitarian-minded micro-managers that the Tony Blair government has unleashed under its cynical slogan of citizen health "empowerment". January 29 - She's fat! I hate her! - We'll let the photo speak for itself. Perhaps we're hopelessly old fashioned but the candid shot to us reveals a beautiful woman striding on a beach. Certainly we know what we'd look like if caught unawares in a Speedo on a sandy playa down under. Her name is Tyra Banks and she used to strut the cat walks in Milan, Paris and New York. Over the hill at 33, Ms. Banks has, according to a snide report, really let herself go and now is fat, fat, fat. Ms. Banks rightly calls the gossip column that slams her girth a "strange meanness and rejoicing." We'd prefer calling it hate but what we truly don't like is how the victim of fat phobia apologizes for being less than svelte. Never agree with the haters and never apologize. Hold the mirror up to their ugly faces and let their obscene hatred speak for itself. January 29 - Obesity of China's kids stuns officials - For veteran observers of the Big Health politics-and-publicity machine, it sometimes seems like a Big Health Medium Term Planning Committee must crank out these headlines six-months to three years in advance, stick them in a file, then queue them up to be matched with a press release when the time is right. Don't reporters, no matter how blasé, jaded and disempowered, ever get bored with it all? Country by country, month after month, "officials" get regularly "stunned" by the extent of obesity in their jurisdiction, and become predictably very concerned about "An American-style obesity crisis" in their own back yard. Wouldn't it be great if some media outlet had the budget - and the will - to follow the grant-and-corruption trail we strongly suspect is a universal run-up to every "shocking" new "obesity crisis"? By the way, the lead for this article incredibly manages to make it sound like bad new that "urban Chinese boys age 6 are 2.5 inches taller and 6.6 pounds heavier on average than Chinese city boys 30 years ago." We should hope so. Thirty years ago, the Chinese were getting by on sparse rice rations that were painstakingly calculated to provide just enough calories to maintain an individual, and nothing more. The availability of proper adequate nutrition remains an issue in some rural areas today. As we read on, it becomes clear that the real "news" here is that many more of the Chinese people are now well-fed. And the final word is left to a Chinese parent who remembers the bad old days: Last week at a McDonald's in Beijing, salesman Liu Guojian beamed while his daughter Xinyi, 7, ate a hamburger. "Our daughter will definitely be taller than us. She has eaten better than my wife and I," Liu said. "When I grew up, in winter all we had to eat was cabbage." But someone has decided that a scary "obesity" headline is the only way to spin any story that contains the word "food". January 25 - Salt reduction demanded - A bossy, so-called health promotion group demands that the US Department of Agriculture (USDA) limit the amount of salt that can be used in meat and poultry products. In this press release dressing itself up as news, the Center for Science in the Public Interest (CSPI) huffily demands that the USDA remove salt from the list of substances "generally recognized as safe." CSPI wants salt to be treated as a food additive, a typical distortion of reality that is common to health pressure groups. The CSPI, which is made up of people who haven't worked a day in a legitimate business, assures consumers that food products will be just as tasty using the amount of salt the group deems sufficient. Just as restaurant and bar owners are judged by the elite as too stupid to run their own businesses by catering to the customer base they wish to attract, often smokers, so too food purveyors are too dim to be trusted with keeping their customers happy. CSPI is happy to run other people's business without assuming any of the risk. The Center for Science in the Public Interest is supported financially by a pharmaceutical front group so this organization doesn't have to worry about where its next pay check will be coming from. January 17 - Monkey see, monkey do - America's role of global nanny is pre-eminent as this article from Australia makes clear. The regulators down under, or Health Police, as the headline describes them, are champing at the bit to join the health hysterics in the United States by banning trans fats. The author is firmly on board the ban wagon but doesn't have any facts to justify her position. This makes for some hilarious reading - the biggest side-splitter being her assertion that New York City is a liberal utopia - as she gamely tries to justify the state's intrusion into areas in which it has no business. The proof is in, so the author claims, that trans fats cause heart attacks, hypertension and stroke. Too bad thatno such proof exists, a fact that doesn't make a dent in the author's feeling that the "obesity epic [is] spanning the globe." While even the experts don't know how many lives will be saved once trans fats are banned, they do know exactly how many billions are spent on drugs that lower cholesterol. The implication being that no more trans fats, no more need for cholesterol-lowering drugs. Add in the savings resulting from reduced sick days, lower health costs and the reduction of health education campaigns and the public reaps an enormous dividend by eliminating trans fats from the face of the earth. New York's action on banning trans fats is to be emulated because it wasn't Michael Bloomberg, the anti-smoker mayor who banned trans fats but the board of health, whose decision to ban wasn't based on political considerations (!!!???) There is "no safe level of artificial trans fat consumption." Just like one cigarette leads to lung cancer and a whiff of tobacco smoke gives a non-smoker a heart attack. Banning trans fats, prohibiting smoking in restaurants and bars don't curtail civil liberties, they promote them. The author indeed has drunk deeply from the Kool-Aid pushed by the behavior regulators. Bring on the bans! We, the great unwashed, will venerate you, our betters, for saving us from ourselves. For an antidote to such self-destructive delusion, be sure to check out the comments under this article from one reader from Canada.	cc/2022-05/en_middle_0076.json.gz/line55

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