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All Abolitionism Media SCOTUS Higher Law Humanity Bloodguilt
Should Women be Punished for Murdering Their Own Son or Daughter by Abortion?
April 13, 2017 By Abolish Abortion WI
Donald Trump caused a firestorm recently when being grilled by Chris Matthews of MSNBC as to whether there should be punishment for women if abortion is made illegal. Trump, who clearly never thought about this before, said what any rational person would say – “Yeah.”
This caused a chorus of furor from the GOP, Trump’s presidential opponents, countless pro-life/pro-family groups, and every leftist in America.
But what Trump said was a no-brainer.
Any thinking person understands that when something is legislated as a crime, there is a consequence if you commit the crime. If abortion is murder – and it is – the woman should be punished. When a murder takes place – all those who are party to the crime are charged with murder.
But see, the “pro-life movement” in this nation has made the woman into a victim. That’s right – they actually want us to believe that the woman who hires a paid assassin to murder her own child is in fact a victim herself.
There is something absurd about calling abortion the capital crime of murder (as pro-lifers and Christians rightly do), and then saying there should be no punishment for the person who hires a paid assassin to murder their own son or daughter. This moral schizophrenia is an insult to the very nature of justice.
Having stood outside abortion clinics for hundreds of hours, I can assure the vast majority of women coming to murder their children know exactly what they are doing. If it were illegal, they would all be without excuse.
I remember when I was young hearing a Right to Life leader say that abortionists should only be given a ticket the first time they are caught committing an abortion. That statement, coupled with his follow-up that women should receive no punishment at all, left me thinking – so what’s the big deal about abortion?
If those who are opposed to abortion think the penalty should be a ticket and nothing at all, surely the killing of the preborn cannot be that big of a thing. Abortion is just a “not-nice” thing. Do you see the inconsistency between calling abortion “murder” and then stating such penalties for committing such an act?
I can assure you that if you read the comment sections of articles about pro-life/pro-family groups condemning Trump’s statement – you readily see that the wicked see the inconsistency.
Americans United for Life – like National Right to Life and most pro-life/pro-family organizations in America – is an organization who has enriched itself off the bloody backs of the murdered preborn for decades by promoting their endless incremental laws against abortion – while at the same time attacking Personhood Amendments or any legislation that could simply bring an end to the killing immediately.
Not surprising therefore that AUL’s Clark Forsythe has written to convince pro-lifers that women should not be prosecuted. In fact, the pro-life movement has been conducting a nationwide campaign (your donations at work) for years now to remove all anti-abortion statutes off the books in states that did criminalize the actions of the woman – all while promoting the mantra that the woman is a victim.
For example, here in Wisconsin in 2011, after taking office our GOP governor, Scott Walker, along with the majority GOP Assembly and Senate – repealed and gutted all punishment for women in our ages-old anti-abortion statute. This was all done at the behest of Wisconsin Right to Life, NRTL, AUL, and others. What the wicked Democrats couldn’t accomplish for years was accomplished by the GOP and the “pro-life” organizations.
They are spitting on the humanity of the preborn child.
Even The U. S. Supreme Court saw the inconsistency of such non-penalties. Blackmun used the lack of punishment to the woman and the low punishment to the abortionist as proof that the preborn child must not be “a person.”
The Roe v. Wade opinion reads:
“There are other inconsistencies between Fourteenth Amendment status and the typical abortion statute. It has already been pointed out, n. 49, supra, that, in Texas, the woman is not a principal or an accomplice with respect to an abortion upon her. If the fetus is a person, why is the woman not a principal or an accomplice? Further, the penalty for criminal abortion specified by Art. 1195 is significantly less than the maximum penalty for murder prescribed by Art. 1257 of the Texas Penal Code. If the fetus is a person, may the penalties be different?” [Endnote 54]
The Court is pointing out the incongruity of the Texas law. 1.) The 3 to 6-year sentence for the abortionist came far short of the capital punishment proper to anyone convicted of the premeditated murder of another person; and, 2.) the mother is not punished at all.
The Court is saying “If the preborn child is a ‘person’, why no penalty for the mother and such minimal penalty for the abortionist?” By refusing to criminalize the actions of the woman and instead labeling her a victim – we undermine both the humanity of the preborn child and the rightly stated argument that abortion is murder.
When we are asked what the punishment should be for women who have illegal abortions, we should unashamedly respond – whatever the penalty is for murder in the state where it takes place.
Of course, as Christians, we offer the good news of redemption through Christ to those guilty of abortion, just as we would any other criminal guilty of a capital crime. But that does not negate the God-given role of the civil magistrate to administer just punishment on behalf of society.
To think otherwise about this matter, is to give credence to the present matriarchal bloodlust in our nation, just as the Romans gave credence to the past patriarchal bloodlust of fathers who could murder their own sons and daughters by leaving them at the infanticide wall to die.
By Pastor Matt Trewhella
Abortion and Punishment blog Life Misinformation Moral Decay Pro-life Pro-family
3 Negative Consequences From Not Prosecuting Parents For Obtaining Abortions
We Have Forgotten God
Celebrating Useless Legislation in Ohio
Milwaukee’s New Planned Parenthood
The Pro-life Reaction to Abolitionist Legislation
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AAWI March 2017 Abortion and Punishment Abortion Exceptions Agitation AHA-101 blog Bloodguilt Conception Declaration of Sentiments Events Federal Beast Glover Ceremony Glover Conference Glover Street Activities Gospel Centered History Homosexuality Humanity ICAS Incarnation Incrementalism vs. Immediatism Interposition IVF John Marshall Joshua Glover Judgment Judicial Supremacy Kabeer Gbaja-Biamila Lesser Magistrate Doctrine Life Misinformation Moral Decay notavictim Personhood Pro-life Pro-family Regulation Repentance Republican Nominees Righteous Resistance Romans 13 SCOTUS Slavery Stare Decisis Supremacy Clause Video
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Parents, Kids & Swine Flu Parties?
David Puente
AC360° Producer
You can probably picture the scene. Well, sort of...
Parents gather in a suburban living room, eating cookies, having coffee and discussing how quickly their children outgrow their new clothes.
Meanwhile, in the play room, the kids lay on mats and cushions, tired from an intense hide-and-seek and tag session. But then, the parents encourage the children to share ice cream spoons, whistles, soda cups even bubble gum.
Does that sound strange? Maybe. But this is exactly what happened at chicken pox parties that some of us grew up with. And the point is to have the boy with the red dots on his face infect all of the small children in the room.
Usually parents who want their healthy children to get chickenpox believe it will help them build immunity against more virulent strains. Others oppose vaccination.
Now there's a buzz on the Internet about “swine flu parties,” and it has medical experts across the country up in arms as the H1N1 virus continues to spread across the U.S. In fact the US Centers for Disease Control and Prevention, (CDC), says it “expects that more cases, more hospitalizations and more deaths from this outbreak will occur over the coming days and weeks”.
The latest numbers in the US according to the CDC: There are 43 states reporting cases, in total there are 1,639 cases and two deaths.
The “swine flu party” chatter on flu web sites and public health blogs like Effectmeasure and flutrackers.com has even gotten the attention of a top US health official.
Filed under: 360° Radar • David Puente • H1N1
Live Blog from the Anchor Desk 05/07/09
Tonight on AC360°, we'll have the latest on the arrest of Drew Peterson. Tonight, he has been charged with killing his third wife, Kathleen Savio. Could he also faces charges in the disappearance of his fourth wife, Stacy Peterson? He has denied harming either of them.
Don't miss Erica Hill's webcast on the case and tonight's other headlines during the commercials. Watch our WEBCAST
Want to know what else we're covering tonight? Read EVENING BUZZ
Keep in mind, you have a better chance of having your comment get past our moderators if you follow our rules.
1) Keep it short (we don't have time to read a "book")
2) Don't write in ALL CAPS (there's no need to yell)
3) Use your real name (first name only is fine)
4) No links
5) Watch your language (keep it G-rated; PG at worst - and that includes $#&*)
And take a look at our live web camera from the 360° studio. Watch the WEBCAM
Filed under: Live Blog • T1
Saving Chicago's kids
Program Note: Tune in tonight to hear more from David Mattingly on the violence in Chicago on AC360° at 10 p.m. ET.
A memorial honoring the children victimized by the violence in Chicago.
David Mattingly | BIO
So often we see grieving communities reacting to Chicago's youth violence by targeting guns. There have been marches protesting gun shops and legislation filed aimed at tougher background checks for gun buyers. But veterans of the fight against the killing are starting to change their tactics. They are looking past the guns and focusing on the shooters.
Ron Holt, whose son Blair was shot and killed two years ago, was a key lobbyist pushing for a tougher Illinois gun law. He failed by five votes. Today he says he is seeing success by going straight to the the would-be gangbangers.
Holt now joins other men in the group called CeaseFire. Groups go out onto the street and try to settle conflicts and diffuse confrontations before they turn violent. Holt says it's working. He's probably helping save more young lives than he did in the state legislature.
Filed under: Chicago Killings • David Mattingly • Gun Violence
Wesleyan University Will "Begin to Return to More Regular Operations"
Editor's Note: A letter from the President of Wesleyan University to the university community after the shooting of a student at a bookstore-cafe near campus. More on the situation tonight at 10 p.m. ET.
Police are conducting a nationwide search for suspect Stephen Morgan and fear he might target others.
Michael S. Roth,
President, Wesleyan University
I want to express my heartfelt thanks for the many messages of concern and offers to help that we have received from you after yesterday’s tragic shooting of Johanna Justin-Jinich ’10. As you might imagine, this is a very difficult time at Wesleyan. To know that we are in your thoughts is a great comfort.
After extensive consultation with law enforcement officials, we have decided to begin to move the campus to more regular operations, starting with opening Usdan for a few hours this evening. My wife Kari and I (along with many other faculty and staff) have just come from eating there. We are instructing students to remain indoors after dinner tonight, but meals are being served, tomorrow morning the library will re-open, and before noon tomorrow there will be an announcement of a new, very flexible schedule for final assignments.
But we are still grieving; we still mourn.
Tomorrow at 1 p.m., two days after the shooting that took the life of Johanna Justin-Jinich , Wesleyan will hold a brief memorial vigil in the Huss Courtyard behind the Usdan Center. There will be time for Johanna’s friends and family to plan other ceremonies at Wesleyan, and perhaps elsewhere. But tomorrow we will gather just to be with one another and remember. We will pay our respects to Johanna’s all-too-brief life.
Filed under: 360° Radar • Crime & Punishment • Gun Violence
Evening Buzz: Drew Peterson Arrested
Drew Peterson was arrested Thursday on murder charges relating to his third wife, Kathleen Savio.
Maureen Miller
AC360° Writer
Tonight on AC360°, we're covering breaking news on the arrest of Drew Peterson. Remember him? He's the former police sergeant in Illinois who authorities call the prime suspect in the disappearance of his fourth wife, Stacy Peterson. But just hours ago a grand jury indicted him for the murder of his third wife, Kathleen Savio.
Savio's death had been ruled an accidental drowning after her body had been found in an empty bath tub in March 2004, just days away from divorce. But her family insisted the death was linked to foul play. Authorities exhumed the body, tests were performed, and her death was then ruled a "homicide staged to look like an accident."
The same grand jury that has indicted Peterson on the death of his third wife is looking at whether he should also be charged in Stacy Peterson's disappearance. She vanished October 2007. Peterson has said repeatedly that she left him for another man.
Peterson is now engaged to a woman that would become his fifth wife. But that wedding may be put on hold, since he faces this new legal battle.
Join us for more on this breaking story and tonight's other headlines starting at 10pm ET.
Filed under: Maureen Miller • The Buzz
Drew Peterson charged with murder, authorities say
Drew Peterson, the former police sergeant who authorities call the prime suspect in the disappearance of his fourth wife, Stacy Peterson, has been indicted on murder charges related to his third wife, the Illinois state attorney's office said.
Illinois state police said Peterson was taken into custody Thursday.
Charles B. Pelkie, state attorney for Will County, Illinois, said a grand jury indicted Peterson in the murder of his third wife, Kathleen Savio, whose death had been ruled an accidental drowning.
He said the grand jury continues to meet and is studying the possibility of charges in Stacy Peterson's disappearance.
After Stacy Peterson went missing in October 2007, media frenzy and police scrutiny on Peterson revealed Savio had died mysteriously a few years earlier during a nasty divorce.
Savio died just before the division of the marital assets was finalized, making Drew Peterson the sole beneficiary.
Filed under: Crime & Punishment • What You Will Be Talking About Today
The ugly truth behind the first U.S. face transplant
Culp, an Ohio mother of two, lost the mid-portion of her face after a gunshot wound in September 2004.
Connie Culp, 46, was identified as the first recipient of a face transplant in the United States.
Cate Vojdik
AC360 Writer
A shot gun blast fired at point blank range blew away much of Connie Culp’s face five years ago. Think about those words for a second. A shot gun blast. To the face. Fired at point blank range.
Culp’s husband pulled the trigger.
We learned those chilling facts Tuesday, when the first U.S. recipient of a face transplant revealed her identity for the first time.
Culp’s press conference at the Cleveland Clinic got a lot of coverage, most of which focused on the extraordinary surgical procedures that gave Culp a new face. The fact that she was left horribly disfigured–to the point where children ran from her–because her husband shot her in the face didn’t get as much attention. Culp herself has said she wants to move on with her life and has forgiven her husband, who is serving a seven-year prison sentence.
Today we’re following another story involving a woman shot at point-blank range, allegedly by a man she knew. Johanna Justin-Jinich, a junior at Wesleyan University, was working at a bookstore-café near the campus when she was killed yesterday afternoon. Police have launched a nationwide search for 29-year-old Stephen Morgan, against whom Justin-Jinich filed a harassment complaint nearly two years ago. He’s the main suspect.
Filed under: Cate Vojdik • Gun Violence • Medical News
Ronnie interviews his Mom
Program Note: Tune in tonight to hear more about the violence in Chicago on AC360° at 10 p.m. ET.
Student activist Ronnie Mosley interviews his mother, Yolanda McBride. She describes how family members have been affected by the violence in Chicago and what it was like to become a parent at the age of 13.
Filed under: 360° Radar • Chicago Killings • Gun Violence
Me? A Terrorist?
Program Note: Tune in tonight to hear Drew Griffin's full report tonight on AC360° at 10 p.m. ET.
Passengers wait in line for their names to be checked against terror watch lists.
Drew Griffin | BIO
CNN Investigative Correspondent
And I thought it was just me.
It was shortly after we did some pretty scathing reporting on the Federal Air Marshalls service that I found myself labeled a potential terrorist at airports. I never could connect the dots to say there was some sort of retribution, but the hassle of being stopped every time I flew (which is a lot) and asked to provide identification, even my mother’s maiden name, before being allowed to print a ticket, slowed me down and created quite an issue when I was running late.
Instead of suffering alone, I decided to bring you all along for the ride, exposing what I thought was a complete blundering of the terror watch list. My first report focusing on how I found myself on the terror list erupted into a flood of calls from people just like me. All walks of life, even a commercial airline pilot, we were all on that list. And every time I filed a report I got the same retort from the Department of Homeland Security: “Mr. Griffin, you are not on the list.”
Well guess what? Thousands of us are really on that list, and yes, thousands of us are on it by mistake. A just released Inspector general’s report lays it all out. And the report also reveals who’s not on it. I’ll share that with you tonight
Filed under: 360° Radar • Airline Safety • Drew Griffin • Terrorism
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Two ASU professors awarded fellow status at National Academy of Inventors
Travis Arbon
Two Arizona State University professors have been named fellows at the National Academy of Inventors, which awarded the honor to 170 people this December. This award further cements them among the top inventors in the country.
The work of Stuart Lindsay, Director of the Center for Single Molecule Biophysics at ASU’s Biodesign Institute, with atomic force microscopy led to the founding of Molecular Imaging Corporation.
Stuart Lindsay directs the Center for Single Molecule Biophysics at ASU’s Biodesign institute.
Michael Kozicki directs the Center for Applied Nanoionics and is the inventor of ionic memory, which is intended to replace flash memory. He also holds 48 US patents and 27 international patents.
Related: Drumroll please! Spirit of Enterprise Award winners include IO and I-ology
The NAI is an organization that supports inventors and researchers and promotes patents. Fellows are elected by the selection committee on the basis of their contributions as “academic inventors who have demonstrated a highly prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society.”
“Doctors Kozicki and Lindsay exemplify the innovative and entrepreneurial spirit of faculty and researchers at ASU. They have made outstanding contributions to their fields, economic development and society,” says Sethuraman Panchanathan, senior vice president for Knowledge Enterprise Development at ASU. “It is a great honor to have the NAI recognize their innovative and use-inspired work.”
Michael Kozicki directs the Center for Applied Nanoionics.
Read: Topping the charts again- ASU’s tech transfer arm ranked highly for third year
Lindsay and Kozicki are among 170 people elected as fellows by the NAI. The new fellows will be inducted at a conference in March 2015 at the California Institute of Technology. Fellows will be given a trophy and a pin to honor their achievements, which is pretty rad.
“We are delighted to recognize the 2014 NAI Fellows and their unparalleled commitment to excellence in academic invention,” said NAI President Dr. Paul R. Sanberg. “Their many discoveries have made a truly significant impact on society and we are proud to honor them for these contributions.”
Contributions from NAI and ASU Communication. Photos courtesy of ASU
ASU award fellows innovation national academy of inventors professors
Mojo to the max! Annette Zinky shares secrets of company culture
2014 AZTB Startup Wrap up
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Home > News > Event > 2nd International New Technologies and Expert Meeting (Part 3)
2nd International New Technologies and Expert Meeting (Part 3)
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Summary of the Second International New Technologies and Expert Meeting
In 2015, the Non Inva Meeting has transformed itself into the 1st New Technologies and Expert International Meeting. We were happy to welcome again friends in Lyon and to continue to deliver state of the art expertise and a focus on innovative technologies in the bariatric field. The general theme of this 2017 meeting has dealt with weight-loss trajectories after bariatric interventions: Can they be improved? For a given intervention, is there a specific trajectory (or a set of trajectories) that can be well defined, i.e. a "signature".
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By Jerome Dargent Co-Chairman, Non-Inva/New Technologies and Expert International Meeting
Organising such a meeting has become a challenge over the past few years. We are still convinced that while bigger meetings are important, more focus on key-issues and more discussion with a perspective are provided in smaller reunions. Times have changed, and there is nobody to blame for this. The industry has reduced is support, and new regulations have made it difficult for physicians to attend meetings abroad. We will continue to discuss the strategy with the companies designing new materials, while staying optimistic: innovative devices are implemented every year, and need a thorough evaluation, particularly in the endoscopic field.
Metabolic and hormonal effects of endoscopic bariatric procedures
Presented by Marek Buzga (Czech Republic)
Despite best efforts, conventional medical T2DM treatment is not always effective Based on CDC statistics: 43% of patients do not achieve HbA1c < 7.0%. Metabolic surgery is established as more effective and durable than medical management for treating T2DM in severe and non-severely obese patients,but surgery is selected by only 1%-2% of the eligible population.
Balloons: Ghrelin is produced in the gastric fundus and the intestine, it is an appetite stimulant and participates in the adaptive response to weight loss; it elevates in states of hunger, and rapidly declines post-prandially. Ghrelin secretion is suppressed by RYGB and LSG. There are various methods measuring ghrelin (ELISA, Multiplex). The peak of Ghrelin is 3 months after surgery, but not many studies measure the active Ghrelin. Six months after placement of the balloon, the rate of metabolic syndrome in the patients decreased from 42.9% to 15.1% (p < 0.005).
DJBS treatment (Endobarrier): in patients with T2DM, the HbA1c level was decreased at 6 months compared to baseline (7.4% to 5.8%; p < 0.005). There is evidence about effect on weight loss, changes in Ghrelin levels, glucose control, blood lipid levels, but the durability of these changes after balloon removal is questioned. Weight loss itself, rather than the DJBS, could be responsible for hormonal variation. DJBS treatment compared with diet and/or lifestyle modifications alone resulted in a modest weight loss in obese subjects, insignificant reductions in HbA1c and FPG and no changes in antidiabetic medication among obese patients with T2D. It was associated with a high number of transient and mild AES and several SAE, causing early explantation in 19% of subjects. Yet the safety profile of DJBS treatment should be seen in the light of its minimally invasive and reversible nature. Long-term high-quality clinical trials, with long post-explantation follow-up periods, are needed to evaluate its applicability in clinical practice. RCTs comparing DJBS with RYGB or intensive pharmacological therapy would be of great clinical interest.
In conclusion, there is an endocrine effect in endoscopic procedures.
FRACTYL (Duodenal Mucosal Rejuvenation) the new metabolic endoscopic technique
Presented by Giorgio G Gobbi (Director, Medical Affairs Europe Fractyl Laboratories)
If the mucosa in patients with type 2 diabetes has been transformed from prolonged exposure to high fat, high sugar nutrients, could we reverse that effect by remodeling the mucosa? In this experiment we took a diabetic rat model and tested the effect of denudation (abrasion) of the duodenal mucosa on glucose metabolism. Compared with sham (no abrasion), the plasma glucose response to an oral glucose tolerance test in the Goko-Kakizaki (GK) diabetic rat was significantly improved from baseline. Denudation of duodenal mucosa conducted through mechanical abrasion decreased 35% of hyperglycemia post oral glucose gavage. Glucose lowering was not observed in sham study or in non-diabetic Wistar rodents
Until now, there have been no pharmacological approaches for targeting this duodenal defect. Bariatric surgery is the only treatment that has provided evidence for duodenal exclusion to provide improved glucose metabolism, but it is a substantial intervention that has not garnered broad enough uptake to impact the worldwide epidemic of diabetes. Duodenal rejuvenation may offer a less invasive solution that works with the patients natural processes to improve glucose handling. Duodenal Mucosal Rejuvenation (DMR) procedure resurfaces the duodenal mucosa post-thermal ablation.
Designed to provide a metabolic reset to approximate the duodenal exclusion in bypass surgery, the procedure is conducted during an upper GI endoscopy: a single-use disposable catheter permits a resurfacing of +/-10 cm of post-papillary duodenum. Procedure: the duodenal mucosa is lifted by saline to create a thermal barrier protecting deeper tissues. Follow up endoscopies and duodenal biopsies at 1 and 3months document mucosal healing. 102 cases have been included. Minimal GI symptoms were observed. There were 3 duodenal stenosis in early experience, successfully treated with a single balloon dilation and no later sequelae; no further cases were seen in the 65 cases after implementation of the improved mucosal lift procedure One jejunal perforation was repaired laparoscopically with no further complications. There was no hypoglycemia, no malabsorption, and no late adverse events (50+ patients >12 months)
Revita-1 Multicenter Open label “Patient Selection” has demonstrated reproducibility of outcomes across EU centers. RCTs will introduce the next generation of catheter, the Revita-2.
VERJU, an innovative and convenient laser for post-operative aesthetic cares in bariatrics
Presented by Simon Ramshaw (United Kingdom)
A randomized pilot study has been recently conducted at the Mayo Clinic (USA), combining low-level laser therapy (LLLT- Erchonia Zeron 2.0). LLT is a non-invasive body-contouring technique that aims at local excess-fat, mostly sub-cutaneous, and does not emit heat, sound or vibration. It allows extravasation of intra-cellular lipids from adipocyte cell membranes. Six independent diodes laser heads emit 532 nm (= green) laser light, generating a 17 milliwatt output. Lasers are focused around the stomach and abdomen for 30 minutes, and then aimed at the back for another 30 minutes.
Lorcaserin is an FDA approved drug, acting as a serotonin 2C receptor agonist while stimulating pro-opiomelanocortin secretion from the hypothalamus, leading to weight loss through satiety. 44 patients (84%) with BMI 27-40 were enrolled in this open-label clinical trial and randomized in three groups: 1) Lorcaserin 10mg twice a day for 12 weeks, 2) LLLT for one hour once a week for 12 weeks, 3) Combination of both for 123 weeks.
Results: Significant reductions in waist circumference were obtained for each group at the end of treatment (-2.3 +/-4.1 cm, -6 +/-7.3 cm, and -4.0 +/-5.5 cm respectively), but the reduction in body weight was only significant in those receiving lorcaserin and combination treatment (-1.3kg). At 6 months, weight-loss was respectively1.4 kg, 2.4kg and 2.0 kg. A significant decrease in triglycerides was observed in the lorcaserin monotherapy group. Non side effects were observed with the LLLT.
RefluxStop trial for GERD, commonly linked to obesity
Presented by Peter Forsell (Sweden) and Milos Bjelovic (Serbia)
Dealing with GERD, there are problems associated with drug therapy, increased risks of esophageal cancer, renal deficiency, osteoporosis, and dementia. The Nissen laparoscopic fundoplication procedure may lead to dysphagia (43% at 4-6 weeks, 19% at 1 year, 18% at 10-14 years); regurgitation in 10%, 2%, 18%; hearburn/epigastric pain in 39%, 17%, 30%. A new mechanical device (RefluxStop) has been developed, that is inserted laparoscopically around the GEJ. With Refluxstop, 92% of the patients had reduced total GERD-HQRL score of more than 50%. One SAE occurred in 22 implanted, an intra-abdominal bleeding (reoperation), there were no device-related AE.
Non invasive neuromodulation as an obesity treatment
Presented by Radwan Kassir (France)
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Comorbidities associated with obesity are related to the autonomous nervous system, e.g. elevated blood pressure or depression. Vagal neurostimulation may act upon these diseases, while when being performed in cases of depression and epilepsy it had also a weight-loss action. The study compared in a double-blind randomized prospective way, the effect of transcutaneous vagal neurostimulation on weight-loss in morbid obese patients (BMI > 40), who were candidates for a bariatric surgery. Vagal branches permeate in the subcutaneous external part of the ear (concha): an electrode was placed in the external left ear and activated by the patient himself 4 to 5 hours a day with intervals of 1 hour at least, with no feeling of electricity intensity (1.0mA, frequency 25 Hz). In the control group, the stimulator was not activated. The secondary objectives was the follow-up of related comorbidities and bio-markers (such as digestive hormones), and the assessment of autonomous nervous system according to the weight-loss.
There was 1 case of local irritation, 2 nausea, 1 increased migraine. We introduced modifications with the earpiece cable length and battery autonomy, and downsized the device. There were 53% premature discontinuation because of lack of compliance. In 17 patients, there was an average 33% EWL. 40% of patient the patients were less anxious, with a good feedback about satiety sensation and reduction of snacking. In order to complete our study, it has been important to unblind the randomisation. We wish to recruit more patients to prove the effectiveness of the device.
Please click here to read Part 1 of the Non-Inva Report or here to read Part 2
2nd NEW TECHNOLOGIES AND EXPERT INTERNATIONAL MEETING
23/08/17 - Event
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17th November, 2016 @08:11 AM
Like every other successful personality, Chris Spielman also began taking his steps to his bright career right from his early life and education by bagging awards like the Lombardi Award entitling the best football linebacker in the college. In 2010, he was also welcomed into the College Football Hall of Fame and received great amount of cheers and applause for his efforts. He was also in Ohio state football team and yet again bagged another award honoring him as Touchdown Club of Columbus’s Chic Harley Award....
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21st November, 2016 @07:11 AM
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Sri Sri Ravi Shankar Quotes, Bhajans, Net Worth and Spiritual Career
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Casbah / Sid's Delight - Tadd Dameron and His Orchestra (Capitol 57-60006)
Personnel: Tadd Dameron (piano, arranger); Fats Navarro (trumpet); Kai Winding (trombone); Sahib Shihab (alto saxophone); Dexter Gordon (tenor sax); Cecil Payne (baritone sax); Curly Russell (bass); Kenny Clarke (drums); Diego Ibarra (bongos); Vidal Bolado (conga); Rae Pearl (vocal on "Casbah")
Recorded in New York City, January 18th, 1949.
Casbah:
Sid's Delight:
Here's something the like of which you don't hear every day. A bebop essay into wordless vocalised exotica, courtesy of El Enmascarado who has ripped us another vintage jazz 78 rpm disc.
Pianist / composer / arranger Tadd Dameron said at a 1953 recording session: "When I write something it's with beauty in mind. It has to swing, sure, but it has to be beautiful." Dameron's search for beauty expressed through music had its starting point when, as a medical student, he saw a body with an almost severed arm dangling from it. That was enough medicine for Tadd. "There's enough ugliness in the world," he decided. "I'm interested in beauty."
He soon acquired the standard big band swing experience which formed the musical background of the bop pioneers, working in the bands of Blanche Calloway, Zach White, Vido Musso, Harlan Leonard and Jimmie Lunceford. Tadd's move into a modern bop style came with his work for the bands of Billy Eckstine ("Cool Breeze") and Dizzy Gillespie ("Our Delight"). In 1947 he had his own small combo featuring brilliant trumpeter Fats Navarro, which recorded for Blue Note and Savoy.
(above: Tadd Dameron and Fats Navarro)
In 1948 his group became the house band at The Royal Roost, a Broadway chicken restaurant which had been running unsuccessful jazz nights until promoter Monte Kay and deejay Symphony Sid stepped in with a policy of promoting the new sounds in jazz combined with regular live radio broadcasts which proved to be fabulously successful.
Which brings us to 1949 where we find Tadd still in residence at The Royal Roost but now with an expanded lineup (sometimes known as "The Big Ten"), which in the eternal quest for beauty through music, combines bop with Latin rhythms. "Casbah" features the wordless singing of Rae Pearl. "Sid's Delight" (named after Symphony Sid) has the tenor sax of Dexter Gordon, who is uncredited on the record label, as you can see from El Enmascarado's scans.
This session for Capitol records was the last to be shared by Tadd Dameron and his collaborator in chief, trumpeter Fats Navarro whose requests for higher pay led to a split.
Many thanks to our collaborator El Enmascarado for the sounds 'n' scans.
Recommended purchase:
2 CD set, Blue Note 3373.
"Jazz Masters Of The 40s" by Ira Gitler, Da Capo, 1984.
Labels: bebop, Capitol Records, Dexter Gordon, Fats Navarro, jazz, Tadd Dameron
You really have been on a bebop binge lately, Boogiewoody! It's wonderful that you're making these discs available (accompanied by the usual high standard of commentary.)
The Bebop's gone to my head, to paraphrase Mr Big Joe Turner. Soon be back to jumpin' 'n' jivin' and rockin' 'n' rollin' Marie!
koen said...
That's adventurous jazz!
Sid's delight unfortunately won't play.
Thanks, Koen "The Rocking Dutchman"
Hi Koen - Sid's Delight has been repaired. You can play it now.
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Battle Of The Blues Volume 4 (King LP 668)
Battle Of The Blues (King LP 607)
Al Sears - Ride The 'D' Train
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Bepartofit HUB
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Accessible Tech Network
Includeon
Digital Inclusion & Innovation Academy
At Bepartofit Hub we are committed to making our website usable for everyone, whatever their abilities or disabilities.
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Our mission is to address some the world’s largest social issues in an inclusive way by creating opportunities and implications of technology to champion and support the most vulnerable. Bepartofit HUB is a community-centred voluntary organisation supported by @UnLtd. You can find us on Twitter @Bepartofithub and like Bepartofithub on Facebook and YouTube.
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UK MPs Continue To Discuss OT’s Registers
The topic of enforcing the UK’s legislation for the British Overseas Territories, including Bermuda, to make their beneficial ownership registers public continues to be discussed in British Parliament and Committees.
According to the Hansard for Thursday, Baroness Stern asked “what technical assistance will be provided to the British Overseas Territories to support the introduction of public registers of beneficial ownership.”
In response, the Minister of State Lord Ahmad said, “I announced at the Overseas Territories Joint Ministerial Council the setting up of technical workshops between the UK and the British Overseas Territories that will be scheduled from spring next year to support the introduction of public registers of company beneficial ownership.
Baroness Stern also asked “how much financial assistance will be provided to each British Overseas Territory to support the introduction of public registers of beneficial ownership, as established by section 51 of the Anti-Money Laundering Act 2018.”
In response, Lord Ahmad said, “The British Government is considering what financial support is possible for the Official Development Assistance-eligible territories to support the introduction of public registers of company beneficial ownership.”
According to the UK Government website, the Overseas Territories which are eligible for Official Development Assistance are Montserrat, St Helena, Tristan da Cunha, and the Pitcairn Islands; none of which have financial services industries.
According to Friday’s Hansard, Labour MP Dame Margaret Hodge asked what discussions the UK Government had during the Overseas Territories Joint Ministerial Council on “requests for assistance provided by the UK Government.”
In response, Minister of State Sir Alan Duncan explained that the UK Government “has not received any formal requests for assistance from the Overseas Territories thus far.”
Baroness Stern also posed a question on Friday which said, “To ask Her Majesty’s Government, further to the Written Answer by Lord Ahmad of Wimbledon on 26 November, which Government departments will be responsible for providing financial and technical assistance to the British Overseas Territories to support the introduction of public registers of beneficial ownership.”
In response, Lord Ahmad said that the British Government departments that will assist in enforcing the British legislation on the territories will include “Companies House, the Department for Business, Energy and Industrial Strategy, the Department for International Development and the Home Office.”
The discussions in British Parliament follow after they passed legislation earlier this year which seeks to allow them to directly order the territories to make their beneficial ownership registers publicly accessible; a move which was condemned by the island’s leaders as a return to colonialism.
A beneficial ownership register is a database of information on business owners, and Bermuda has had one for decades, and provides information to law enforcement and tax authorities at request.
Other nations also have them, and while the vast majority do not make theirs public at this time, the UK made their register public in 2016, and the British Parliament invoked their rarely-used ability to pass laws for the territories with an aim to implement the same policy across all the territories.
UK MPs Discuss OT Public Register Law Again
UK MP Brings Up ‘Sanction Of Direct Rule’ Again
OTs Expected To Have Public Registers By 2023
UK MP: ‘Ending Tax Secrecy Will Bring In £10B’
Lords Vote ‘No’ On Public Register For OTs
British MPs Seeking Public Register Amendment
#BeneficialOwnershipRegister #BritishOverseasTerritories #BritishPoliticians #UnitedKingdom
Category: All, News, Politics
nabbah jabbah ding dong baby daddy says:
are your hands clean?
hold this for me…
« Weather Forecast For Monday December 24
Photos: Chiko’s Smokey Rub Christmas Dinner »
Minister Congratulates Island Games Team
Wood Waste Deferred Until Further Notice
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Peso Pete: you are absolutely right. my voted for MP seems to have laryngitis. out of only 11 we have 1.5 mind
Y-Gurl: Despite all the obvious less than transparent acts, Uigers, ferries, ICS, leaked memos, construction
sandgrownan: The warrants for slavery, racism, bigotry, homophobia, the treatment of women as second class citize
Stinky D.: If they are paperless why they keep on sending me stuff snail mail
Joe Bloggs: Neither do the PLP protesters who were pepper sprayed during a peaceful protest. That’s they were pa
Joe Bloggs: Check your facts. The Caroline Bay (Morgan’s Point) deal goes back to 2011.
Joe Bloggs: Seriously?
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Gay/Lesbian EBooks
Free Gay/Lesbian EBooks for Download
Below we have listed all the Free Gay/Lesbian EBooks for download. Feel free to comment on any Gay/Lesbian EBooks for download or answer by the comment feature available on the page.
Jane Austen in Context (The Cambridge Edition of the Works of Jane Austen) Book: Covering many aspects of Jane Austen's life, works and historical context, this collection of essays provides the most complete one volume introduction to her life and times. The generously illustrated collection of concise contributions is arranged alphabetically, and covers topics ranging from biography to portraits, critical responses to translations, agriculture to transport. An essay on the reception of Austen's work is also included, showing how criticism of Austen has responded to literary movements and fashions. This is a work of reference that readers and scholars of Austen will turn to again and again.
The Joy of Writing Sex: A Guide for Fiction Writers Book: The author has explored sensuality in her own novels with great success. So, in The Joy of Writing Sex, she deftly covers all the issues head-on--from dealing with "internal consorts" to writing about sex in the age of AIDS. Accompanying her instruction are spirited opinions by John Updike, Joyce Carol Oates, Carol Shields, Russell Banks, and many other prestigious writers.
A Treasury Of Humorous Poetry Book: The great end of comedy, quot said Doctor Johnson, in speaking of the drama, is quot making an audience merry. quot Whatever else may or may not be true of a humorous compilation, it is certain that unless such a book is amusing, it is a failure. The aim of this quot Treasury quot is not that of presenting extracts illustrating the development of humorous poetry in the English language. If that were its purpose, the anthology might have greater value for historical students of literature, but for the average reader it would prove of necessity uninteresting.
Educational Research and Innovation Educating Teachers for Diversity: Meeting the Challenge Book: hich can be used to redesign initial and continuing teacher education to help practitioners effectively teach diverse students. It looks at challenges teachers face in OECD countries and presents a range of policies and practices used in various contexts, from countries with long histories of diversity to those with more recent experiences. The key role of evaluation of teachers, schools and systems is emphasised. Educating Teachers for Diversity: Meeting the Challenge asks how these insights can inspire continuing educational reform for our changing classrooms, with a special focus on key questions for research, policy and practice.
The Last Freedom: Religion from the Public School to the Public Square Book: The presidency of George W. Bush has polarized the church-state debate as never before. The Far Right has been emboldened to use religion to govern, while the Far Left has redoubled its efforts to evict religion from public life entirely. Fewer people on the Right seem to respect the church-state separation, and fewer people on the Left seem to respect religion itself--still less its free exercise in any situation that is not absolutely private. In The Last Freedom, Joseph Viteritti argues that there is a basic tension between religion and democracy because religion often rejects compromise as a matter of principle while democracy requires compromise to thrive. In this readable, original, and provocative book, Viteritti argues that Americans must guard against debasing politics with either antireligious bigotry or religious zealotry.
American Buddhism As a Way of Life Book: The United States is becoming more comfortable with Buddhism each year. Celebrity converts, the popularity of the Dalai Lama, a stream of references in popular culture, and mala beads on every third person's wrist all indicate that Buddhism is becoming an accepted part of American life, even if a relatively small percentage of the population actually describes itself as Buddhist. This book investigates the ways in which Buddhist and American ways of life have inflected one another. Gary Storhoff and John Whalen-Bridge have organized this unique collection in accordance with the Buddhist concept of the Three Jewels: the Buddha, the Dharma, and the Sangha. "Buddha" discusses two key teachers who popularized Buddhism: Alan Watts and D. T. Suzuki, correlating their personal situations with the approach to spirituality they proclaimed. "Dharma" is concerned with the impact of Buddhist ideas and texts on the most ing social problems faced by Americans, including bioethics, abortion, end-of-life decisions, and identity theft. "Sangha" treats Buddhism in relation to social relationships, with chapters on family life, generational shifts, Asian American communities, the gay/straight divide, and Buddhist artistic practices-such as the making of a Zen garden-used to strengthen communal bonds.
Counseling Fathers Book: Men do not often come for counseling because they are having difficulties with being a father, but many of the presenting problems and reasons for seeking help can be related to the roles and responsibilities of fathering. The dramatic shift in societal expectations of being a father can often leave men confused as they navigate conflicting views, demands, and responsibilites.
William Shakespeare, Twelfth Night (The New Cambridge Shakespeare, Updated Edition) Book: Edited by Elizabeth Story Donno
Cambridge University Press | 2004 | ISBN: 052153514X | 186 pages | siPDF | 7.5 MB
For this updated edition of Twelfth Night, Penny Gay has written a wholly new Introduction to this well-loved Shakespearean comedy. She stresses the play's theatricality, its elaborate linguistic games and its complex use of Ovidian myths. She analyses the play's delicate balance between romance and realism and its exploration of gender, sexuality and identity. In examining the stage history, Professor Gay suggests that contemporary critical theory could have much to offer twenty-first-century directors and actors. An updated reading list completes the edition.
The Marketplace of Christianity (Repost) Book: This startlingly original (and sure to be controversial) account of the evolution of Christianity shows that the economics of religion has little to do with counting the money in the collection basket and much to do with understanding the background of today's religious and political divisions. Since religion is a set of organized beliefs, and a church is an organized body of worshippers, it's natural to use a science that seeks to explain the behavior of organizations--economics--to understand the development of organized religion. The Marketplace of Christianity applies the tools of economic theory to illuminate the emergence of Protestantism in the sixteenth century and to examine contemporary religion-influenced issues, including evolution and gay marriage.
A Quilted Heart Book: A murder-mystery-ghost-story-romance that manages to subvert all the traps of such genres Daniel MacIvor
When Marsh Cole's body is found in Samson Brindle's pool, who is to blame? Was it suicide, or the vengeful ghost of Sylvian Oulette? From acclaimed poet and playwright R M Vaughan comes the story of three neurotic gay men who fall in love and proceed to torture each other to death -- a twisted fable about love, jealousy, murder, and talking back from the grave.
Free Gay/Lesbian eBooks - Download Gay/Lesbian eBooks - List of Gay/Lesbian eBooks
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Revised Scenes from History, Nº 1
Were People in the Great War As Enlightened As Modern Folk
[An officer, in a clean, well-tailored uniform, saunters into a filthy trench, somewhere near Passchendaele, in 1917, shortly before a scheduled attack.]
Sergeant: Officer present! Attention! Sah!
Occupational Health & Safety Officer: At ease, men; standing to attention is bad for the back. Ah, good, those ladders seem well placed and properly supported. Now are your weapons nice and safe? Ammunition safely put away?
Sergeant: Sah, yes, sah!
Occupational Health & Safety Officer: You, Private—
Sergeant: Hatkins, sah!
Occupational Health & Safety Officer: Ah, Atkins, is your bayonet clean? We don’t want an enemy to catch a nasty infection.
Pvt. Hatkins: Clean, sir, and sharp, sir!
Occupational Health & Safety Officer: Sharp? Sharp!
Sergeant: Well-honed, sah, razor-edged, ὀξύς, acutus—
Occupational Health & Safety Officer: Yes, yes, I know. Are any other bayonets similarly sharpened, Sergeant?
Sergeant: Why, all of them are, of course, sah. We must all be keen, and I always keep a sharp look-out, sah!
Occupational Health & Safety Officer: But we can’t have that—someone may get hurt! Dull these bayonets immediately!
[After a few seconds of stunned immobility, a few of the soldiers begin to strike their bayonets against rocks.]
Occupational Health & Safety Officer: Hey, what are you doing? Stop! That’s dangerous! Someone could put out an eye!
Pvt. Hatkins: We have no proper tools with us here, sir.
Occupational Health & Safety Officer: Sergeant, I leave it to you to ensure that these men dull their bayonets, and safely; but I don’t want to hear that you’ve been shouting at them. It could harm their hearing, and it lowers their self-esteem. I, meanwhile, have an appointment to meet Field-Marshall Haig; I must talk to him about this foolhardy practice of firing artillery shells. Farewell, men.
[The officer departs. The men murmur and mutter.]
Sergeant: All right, shaarp, you lot; you heard the officer, we need to devise a tool to blunt the bayonets.
Pvt. Hatkins: How, Sarge?
Sergeant: Men, form a file.
labels: occupational health and safety, revised history, warfare, WW I
Pres. Obama Sued by Empty Suit
We are shocked to learn, by way of various news services and the neo-neocon blog, some stunning legal news. By documents lodged in a Washington District Federal Court, yesterday, an empty suit is suing U.S. President Barack Obama for defamation of character and fraudulent appropriation of identity:
The plaintiff’s attorney, Nigel Barratry, who has entered amicus curiae briefs and a pair of shorts, explained yesterday that he will, conjointly, also lodge a private prosecution, and that the criminal and civil charges include misuse of usufructuary, misprision, plagiarism, peculation, subrogation, and (by alleging further that the defendant was ineligible to be a candidate for president) obtaining a pecuniary advantage by deception, and treason.
Pres. Obama, according to the suit, has given empty suits everywhere a bad name.
The White House has not yet issued an official response. An inside source, however, said that the briefs had no legs to stand on, and that the President would make an eloquent response as soon as Prof. Bill Ayers could be located to write it.
Meanwhile, Mr. Barratry further revealed that his firm, Amble & Chaser have received scores of communications from numerous other items and apparel—such as windbags, douche-bags, sock-puppets, marionettes and windsocks—, which, feeling similarly deflated and injured, effete and useless, have expressed a wish to join the empty suit’s suit suitably thereunto.
labels: empty suit, Pres. Barack Obama
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Jon Stopak Wins Justin Zak Award for Sales Achievements
BigIron Auctions, rural America’s leading unreserved online auction, recently announced that Jon Stopak, independent sales representative of Duncan, NE has been awarded the Justin Zak Award for Sales Achievement. The prestigious award is given annually by BigIron to a sales representative who embodies honesty, integrity, exceptional organization skills, and efforts for continual improvement in their sales territory.
The Justin Zak Award commemorates the late Justin Zak, a leading independent sales representative and beloved colleague at BigIron. Stopak accepted the award at the 2019 National BigIron Conference in Omaha.
“Justin had a tremendous energy and impact on all who knew him. He was one of the company’s early and most successful sales representatives who deeply cared about God, family and friends. His dedication to his BigIron customers and work ethic was a large part of his passion for excellence in everything he did in business and in life,” said BigIron’s co-founders Mark and Ron Stock.
“Independent sales representatives work with their clients daily, helping them list and sell used equipment on BigIron’s online auction site,” said BigIron CEO Andrew Pyron. “Jon Stopak is not only a high sales achiever, but exceeds expectations by being a great team player who always puts the customer first. BigIron is honored to have him as a positive influence on those around him.”
“I am so honored to be recognized for this prestigious award,” Stopak said. “After Justin left, I knew I had some big shoes to fill. I’m so grateful and honored to have been given this award named after him.”
Stopak has been an independent sales representative for three years, and covers the counties of Platte, Polk, and Merrick, NE. Stopak’s work helps BigIron to connect buyers and sellers of farm, construction, and transportation equipment across the glove through unreserved online auctions.
About BigIron
In 1984, Ron and Mark Stock, both farmers and entrepreneurs, founded Stock Auctions to conduct onsite auctions. Always driven to innovate, Ron and Mark added BigIron Online Auctions in 2009. Now as BigIron Auctions, the company conducts both weekly online and scheduled onsite auctions. BigIron’s online platform allows you to virtually “kick the tires” before you buy. We provide the seller’s information to our online buyers so they have access to the same kind of information they’d get in person. We’ve reinvented the way used farm, construction and transportation equipment is sold to best meet the needs of our buyers and sellers with unreserved auctions, a guarantee of free title and no buyer fees. We are committed to continually improving with a state-of-the-art online platform, global marketing and BigIron Independent Sales Representatives across the nation. From this commitment, we have grown to become the largest unreserved online auction serving rural America, selling tens of thousands of items through weekly unreserved auctions to registered bidders representing a global marketplace.
BigIron News, BigIron Tutorials
Watched List
BigIron News, Lifestyle, Seasons
Measuring Life in Seasons: What Does That Mean to Farmers?
Website Enhancements Released
Annual Nebraska FFA Auction 2017
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My CGE
About CGE
Association between the TP53 Codon 72 Polymorphism and Risk of Nasopharyngeal Carcinoma: A Meta-analysis
Chenggang Mao1* , Xiaochun Zhou1* , Yidao Jiang1 , Lijia Wan1 , Zezhang Tao2
1 Department of Otolaryngology-Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, 434020, China
2 Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China
Cancer Genetics and Epigenetics, 2019, Vol. 7, No. 1 doi: 10.5376/cge.2019.07.0001
Received: 24 Jan., 2019 Accepted: 13 Feb., 2019 Published: 22 Feb., 2019
Mao C.G., Zhou X.C., Jiang Y.D., Wan L.J., and Tao Z.Z., 2019, Association between the TP53 codon 72 polymorphism and risk of nasopharyngeal carcinoma: a meta-analysis, Cancer Genetics and Epigenetics, 7(1): 1-10 (doi: 10.5376/cge.2019.07.0001)
The associations of the P53 codon 72 polymorphism and risk of nasopharyngeal carcinoma (NPC) were inconclusive in several epidemiological studies. In order to get a more consistent result in these two, we conducted these 9 articles of the meta-analysis and systemic reviews to investigate relationships. An exhaustive search was conducted by us in PubMed and Embase databases up to March 2015. Only the studies consisting of NPC patients who were diagnosed by pathological methods were considered. The 95% confidence intervals (CIs) of odds ratios (ORs) were used to assess the association and Review Manager (RevMan) 5.2 software were used to perform statistical analyses. Consequently, there were nine studies were selected, which include 1,588 cases and 1,925 controls met the included criteria. Ultimately, systematic meta-analyses were used to extract relevant data and further analyze. The conclusions indicated that the persons who carried Pro/Pro genotype have an increased susceptibility of NPC compared with the persons who carried homozygote Arg/Arg genotype and heterozygote Arg/Pro [OR 0.59, 95% CI 0.48-0.72; OR 0.66, 95% CI 0.46-0.93]. For Arg allele, the persons with homozygote Pro/Pro genotype have an obviously increased susceptibility to NPC to the persons with an integrated Arg genotype (Arg/Pro + Arg/Arg) [OR 0.62, 95% CI 0.45-0.68]. For Pro allele, the conclusions showed the persons with Arg/Arg genotype have an obviously increased risk of NPC compared with the persons with an integrated Pro genotype (Arg/Pro + Pro/Pro) [OR 0.75, 95% CI 0.64-0.87]. To sum up, the conclusions of the meta-analysis indicate that Homozygote Pro/Pro genotype obviously increased NPC risk in the P53 codon 72; and Arg allele significantly decreased the susceptibility to NPC.
TP53 codon 72; Nasopharyngeal carcinoma; Meta-analysis; Polymorphism
Nasopharyngeal carcinoma (NPC) is an illness which related with geographic distribution and distinct ethnic. NPC has an obvious disease burden in Southern China and Southeast Asia, which has an annual about 20 per 100,000 people incidence rate in endemic areas, but is relatively seldom in the Western world (Jeannel and Bouvier, 1999; Parkin et al., 2002). This tumor has been suggested to result from complex interactions of a variety of epidemiological factors. There was evidence which shows that tobacco smoking, alcohol consumption, infection of Epstein-Barr virus (EBV), more exposure of wood dust and a high-salt diet consumption may be risk factors for NPC (Zheng et al., 1994; Cheng et al., 1999; Key et al., 2004; Gullo et al., 2008; Jayaprakash et al., 2008). Only a few exposed persons of exposed people were developed to NPC, which imply that many interactions in some environmental and genetic factors may be the main reason of NPC, and the carcinogenic mechanisms may be contributed by genetic factors, although the risk factors exposed to many persons.
The tumor protein p53 gene, which located on chromosome 17p13, we called TP53, is one of the most likely mutated genes in human tumors and it is probably to be an obviously decisive factor in form of tumor (Tsui et al., 2009). The codon 72 polymorphism, located in exon 4 of TP53 gene, which called rs1042522 involves a leading to a proline (Pro)→arginine (Arg) amino acid substitution CCC→CGC transition at position 72 (Pro72Arg) (Ara et al., 1990). Many publications have showed that the TP53 codon 72 polymorphism could be connected with increased risk to bladder tumor (Zhou et al., 2012), cervical cancer (Xu et al., 2012). Although in some NPC cases the accumulation of P53 protein was reported, as for NPC, TP53 mutation is a rare event, particularly in the juvenile form (10e11). Instead, for NPC possible susceptibility factors would be polymorphisms of TP53.
The relation of the TP53 codon 72 polymorphism and NPC susceptibility have been studied in several previous articles; but the results are not consistent. Zhuo et al. conducted a meta-analysis of five case-control studies and showed that the TP53 codon 72 polymorphism could be a susceptibility factor for nasopharyngeal carcinoma in 2009 (Zhuo et al., 2009). Further, some more articles have been published recently. Best of our knowledge, whether or not NPC susceptibility could have been increased by the TP53 codon 72 polymorphism remains obviously uncertain. To clear the relation could give us better comprehend the possible risk of NPC and further prevent carcinogenesis. For the reason, we do the meta analysis in order to get precise and latest evaluation of the relation in the TP53 codon 72 polymorphism and NPC risk.
1.1 Characteristics of the study
247 studies that met the included criteria were identified by our systematic literature search. Eventually, 9 case-control studies (Golovleva et al., 1997; Yung et al., 1997; Tsai et al., 2002; Tiwawech et al., 2003; Sousa et al., 2006; Hadhri-Guiga et al., 2007; Xiao et al., 2010; Xie et al., 2013; Zhang et al., 2014), which involved 1,588 NPC patients and 1,925 controls were included, after exclusion and deduplication of the obviously irrelevant studies. The study selection process was showed in Figure 1. Table 1 shows the baseline characteristics of the 9 studies.
Figure 1 Flow diagram of study selection
Table 1 Characteristics of included studies
Note: NPC, nasopharyngeal carcinoma; HPV, human papillomavirus; NA, not available; HB, hospital-based; PB, population-based; HWE, Hardy Weinberg Equilibrium
1.2 Meta-analysis results
Figure 2, Figure 3, Figure 4 and Figure 5 review the summary of the meta-analysis results, which shows the relation in the P53 codon 72 polymorphism and NPC. The results exhibited that there was relative association between P53 codon 72 polymorphism and nasopharyngeal carcinoma susceptibility, after we compared ArgArg vs. ProPro, ArgPro vs. ProPro, (ArgPro + ArgArg) vs. ProPro, and ArgArg vs. (ProPro + ArgPro).
Figure 2 Forest plot
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgArg VS. ProPro genetic model
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgPro VS. ProPro genetic model
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgPro + ArgArg VS. ProPro genetic model
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgArg VS. ProPro + ArgPro genetic model
The meta-analysis indicated the persons who carry homozygote Arg/Arg genotype and heterozygote Arg/Pro have a decreased susceptibility of NPC compared with those who carry Pro/Pro genotype [OR 0.59, 95% CI 0.48-0.72; OR 0.66, 95% CI 0.46-0.93]. For Arg allele, the persons who carry an integrated Arg genotype (Arg/Pro + Arg/Arg) have an obviously decreased risk to NPC relative to the ones who with homozygote Pro/Pro genotype [OR 0.62, 95% CI 0.45-0.68]. For Pro allele, the meta-analysis showed that the persons who with an integrated Pro genotype (Arg/Pro + Pro/Pro) have a marked decreased susceptibility of NPC compared with the ones who with Arg/Arg genotype [OR 0.75, 95% CI 0.64-0.87].
1.3 Publication bias
A relatively symmetrical distribution was showed by a based on the four genetic model funnel plot, which enable us to deduce that there was no publication bias.
The TP53 codon 72 encode Arg and Pro, which are two different functional alleles. And the most informative polymorphism in the TP53 gene is Pro to Arg, which have been found to be associated with the tumors (Ara et al., 1990; Hollstein et al., 1991). Some articles showed an increased risk of disease, among the published publications which explore the relation in the polymorphism and tumors (Xu et al., 2012; Zhou et al., 2012), but some persons could not to find any relation (Matakidou et al., 2003; Sousa et al., 2007; Zhou et al., 2007). The different systematic reviews of the same tumor type could get opposite results, and this is an interesting phenomenon, which is the result from these meta-analyses. Such relation among the people is unclear, although some conclusions were reached by one meta-analyses which studied the relation of the TP53 codon 72 polymorphism and nasopharyngeal carcinoma risk (Zhuo et al., 2009). The systematic review was conducted to further study whether the TP53 codon 72 polymorphism plays an important effect in the form of nasopharyngeal carcinoma, given that NPC has a high incidence in the people. So, the TP53 codon 72 polymorphism is a critical predictive and prognostic marker for the researchers.
Our meta-analysis included a total of 1,588 nasopharyngeal carcinoma patients and 1,925 controls. The meta-analysis indicated the persons who carry homozygote Arg/Arg genotype and heterozygote Arg/Pro have a decreased susceptibility of NPC compared with those who carry Pro/Pro genotype [OR 0.59, 95% CI 0.48-0.72; OR 0.66, 95% CI 0.46-0.93]. For Arg allele, the persons who carry an integrated Arg genotype (Arg/Pro + Arg/Arg) have an obviously decreased risk to NPC relative to the ones who with homozygote Pro/Pro genotype [OR 0.62, 95% CI 0.45-0.68]. For Pro allele, the meta-analysis showed that the persons who with an integrated Pro genotype (Arg/Pro + Pro/Pro) have a marked decreased susceptibility of NPC compared with the ones who with Arg/Arg genotype [OR 0.75, 95% CI 0.64-0.87]. A positive relation of the TP53 codon 72 polymorphism and nasopharyngeal carcinoma was demonstrated by results of the overall population. In the systematic reviews, the current study indicated that the persons who have the homozygote Pro/Pro genotype could have increased NPC susceptibility. In contrast, Arg carriers, particularly the persons who have homozygote Arg/Arg genotype, may have an obvious relation in decreased risk to NPC.
Koushik et al. (2004) indicated susceptibility of both squamous cell carcinoma and adenocarcinoma were increased by homozygote Arg/Arg genotype in cervical cancer. A non-association of TP53 codon 72 polymorphisms was showed by previous publication in lung cancer (Matakidou et al., 2003) and gastric carcinoma (Zhou et al., 2007). And Jee et al. (2004) suggested increased susceptibility of cervical adenocarcinoma, but it did not increase squamous cell carcinoma only associates with Arg/Arg genotype. In the present study, TP53 Arg/Arg genotype seemed unlikely to increase NPC risk, but Pro/Pro genotype may act as a risk factor.
The most often studied gene, which is often mutated in some tumors is TP53. This is unclear that the reason underlying TP53 polymorphism increasing NPC risk. However, TP53 gene has reported a few single-nucleotide polymorphisms (Pietsch et al., 2006). TP53 protein is thought to play an important role in apoptotic functions and growth suppression and a proline-rich region was occurred by the polymorphism of TP53 codon 72 (Dumont et al., 2003). Their ability of combining the transcriptional protein, suppressing the transformation and activating transcription of some primary cells were differed by the two polymorphic variants (Chang et al., 2002). Pro variants may induce apoptosis worse than Arg variants do, which may be attributed to the capability of the Arg variant to locate to mitochondria and it controls the release of cytochrome C into cytosol. Thus, at least partly Pro variant seemed to interrelate to apoptosis suppression of cells, which is an important convincing mechanism of tumor form. The distinctive could be the reason that why the Pro allele could increase susceptibility to NPC. In addition, TP53 gene may interact with other genes such as P73 and melanocortin 1 receptor (Nan et al., 2008). Also, it may have a combined effect with some epidemiological factors such as smoking and alcohol consumption, leading to NPC tumorigenesis and progression.
However, there was a number of limitations in the meta-analysis. First, various factors limit the publication, because the publication is a secondary retrospective study, which include the used measurement tools, the original studies quality, and study population differences, like all other meta-analyses. Second, although the publication is very common in systematic reviews of genetic studies, statistical heterogeneity is critical. Therefore, random-effects model analyses were performed by us to think over the factors which could have led to the high level of heterogeneity. Third, this is the reason that the comprehensive genotype information was lacked in our included studies, which induced using unadjusted data analyzed the results of our systematic review. And because the strict inclusion criteria, the studies which been included is small and it is not sufficient to estimate the two relationship. So, based on other adjusted factors, we could not form a more precise analysis. Finally, the number of the systematic review is relatively small and we did not consider the publications for inclusion in languages only including Chinese and English. So, in order to get more precise conclusions between the two, further research should be studied.
3 Materials and Methods
All analyses were based on previous published studies, thus no ethical approvals or patient consents were required. This recommended Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines is adhered to the meta-analysis (Moher et al., 2009).
3.1 Inclusion criteria
Case-control studies which should met the following eligibility criteria were included: (1) polymerase chain reaction (PCR) which include PCR-polymerase chain reaction-single strand conformation polymorphism (SSCP) and PCR-polymerase chain reaction restriction fragment length polymorphism (RFLP) for genotyping were used to genotype; (2) The relation in the TP53 codon 72 polymorphism and NPC susceptibility is evaluated; (3) enabled the genotypes to be computed from the available publications, or the number of the persons genotypes in both the case and control groups were provided; (4) NPC patient who were diagnosed by obviously reported the type or, histologic methods and cancer-free controls or contained healthy were included; (5) the publications should be published in Chinese or English.
3.2 Search strategy
Some databases were searched up to March 2015, which include EMBASE, MEDLINE, AMED, EBM, ACP, Health Technology Assessment, NHS, CNKI and so on. And we searched the following items: [(nasopharyngeal) AND (cancer OR carcinoma) AND (p53 OR TP53) AND polymorphism]. Additionally, we screened for additional studies which included published studies on interrelated topics and the included studies reference lists.
3.3 Data extraction
The following trial data which was extracted from included studies was extracted by two authors independently: the year of publication, the names of the authors, the countries of the publication, the NPC diagnostic method, the method of genotyping, source of control, cases and controls numbers and the genotyping distributions, and the controls Hardy-Weinberg Equilibrium (HWE) (Salanti et al., 2005). If there were disagreements, we should discuss to resolve them.
3.4 Statistical analysis
The Chi-square test (χ2; heterogeneous was p<0.10) and the inconsistency index test (I; indicate higher heterogeneity shows larger I values) evaluated assessment of heterogeneity. Any significant heterogeneity selected to solve the random effects model in the studies. If not, it should use the fixed-effects model (Mantel-Haenszel) (Moher et al., 2009). Publication bias was used to evaluate the Egger regression asymmetry test (Salanti et al., 2005) and Begg’s rank correlation test (Huedo-Medina et al., 2006) and indicative of a lack of publication bias considered a p value of >0.05. We used STATA version 12.0 (StataCorp, Texas, USA) to perform statistical analyses, and it was considered significant, when <0.05.
The fixed-effect analytical model first to pool results of the included studies were employed and statistical heterogeneity was tested by I2 statistic (Huedo-Medina et al., 2006). It should be switched to a random-effects model, once I2 was more than 40%. In order to quantify in the TP53 codon 72 polymorphism the strength of relation, we used relevant 95% confidence intervals (CIs) and the odds ratios (ORs). And we used four genetic models to assess NPC risk: ArgArg vs. (ProPro + ArgPro), (ArgPro + ArgArg) vs. ProPro, ArgPro vs. ProPro, and ArgArg vs. ProPro. We used examination of funnel plots to detect publication bias. And Review Manager (RevMan) software (version 5.2 for Windows) was used to conduct all statistical analyses.
In conclusion, this systematic review indicated that TP53 codon 72 polymorphisms are interrelated with NPC risk. Homozygote Pro/Pro genotype could obviously increase risk to NPC, and Arg allele critically decreases NPC risk at the same time.
MCG and ZXC wrote and translated the manuscript. TZZ read and approved the final manuscript. JYD and WLJ collected materials. All authors read and approved the final manuscript.
This paper is the outcome of the Jingzhou City project supported by grants from the Science and Technology Program of Jingzhou City (nos. 2017038; 2017044). The authors would like to express their great appreciation for the invaluable assistance of Chen Z. and Zhang Z.X.
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Cancer Genetics and Epigenetics
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. TP53 codon 72
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Braves Go Cyber Monday Shopping, Bolster Lineup
By Bud ⋅ November 27, 2018 ⋅ Post a comment
ATLANTA – There were plenty of people who did their research, scoped out the best buys, figured out their budget and set their sights on Cyber Monday, one of those holiday events where many of us upgrade our wardrobe, electronics or household.
Who knew Alex Anthopoulos also had that day circled on his calendar?
Now granted, the Braves general manager probably did not set out specifically to make the first two moves of this pivotal offseason on the same day you were saving 30 percent on a pair of jeans and a flat-screen TV. But when you slip on those new jeans and fire up that TV come April, you’re going to see a familiar face and a hugely impactful face wearing Atlanta Braves jerseys.
Atlanta welcomed home longtime catcher, Duluth (Ga.) native and eternal fan favorite Brian McCann on Monday, signing the veteran catcher to a one-year, $2 million deal. Injuries and decreased offensive production diminished his impact the past two seasons in Houston, but one of the better framing catchers in the game did help the Astros win the 2017 World Series. Reportedly, the soon-to-be 35-year-old turned down more lucrative offers for the chance to play in front of family and friends in his hometown.
Certainly, this move did not move the needle holistically as much as it did for sentimental reasons. This correspondent even tweeted that this move did not look great at the moment, but likely would in a month or two given the moves that would come, taking care of the catching position, not spending but a mere pittance (in baseball terms) to get it done. After all, this is not the same player who made seven All-Star appearance wearing an Atlanta uniform earlier in his career.
Then came news – merely minutes after McCann’s signing was announced by the club – that made adding a catcher who hit .212 in 63 games last season much more tolerable, sentiments be darned.
The Braves inked slugging third baseman Josh Donaldson to a one-year, $23 million deal late Monday, reuniting the former Blue Jay with Anthopoulos, the general manager who acquired the Auburn University product after the 2014 season to help Toronto reach back-to-back AL championship series.
That’s a lot of money for a guy who, like McCann, has dealt with injuries the past two seasons. But any return to form for Donaldson, who will be motivated to parlay this one-year deal into a huge free-agent contract come next winter, would pay tremendous dividends for an Atlanta lineup that – for all its sizzle and shine a season ago – lacked the right-handed power threat to slot behind Freddie Freeman in the cleanup spot.
There’s a lot to like about these deals together, from an inward and an outward perspective.
Inward, the Braves are a better team now than they were at sunrise. McCann will provide tremendous leadership behind the plate for Atlanta’s youthful staff, the catcher certainly benefitting from working with the likes of CC Sabathia and Justin Verlander since he left the Braves after the 2013 season. He gained valuable experience playing in the postseason with the Yankees (who he signed with after leaving Atlanta) and Houston, including the 2017 World Series title.
Likewise, Donaldson has his share of playoff experience, including the aforementioned two years with Anthopoulos north of the border. The soon-to-be 33-year-old only played 52 games a season ago, but slugged 33 homers with a .944 OPS in 113 games the year before, and only is three years removed from a MVP campaign in which he blasted 41 homers and drove in 123 runs. Anything approaching those numbers in 2019 gives the Braves one of the absolute most dangerous lineups in the NL, hands down.
And what of Johan Camargo, the young fan favorite whose anchoring of third base the final four months of 2018 is hailed as one of the reasons the rebuilding Braves transitioned into the playoff-clinching Braves? Folks, I can’t see Camargo going anywhere. He has experience playing three infield positions, will get some work at first base and corner outfield in camp, and profiles exactly as the type of player Martin Prado was at one time and Marwin Gonzalez (McCann’s former Houston teammate) is at this time.
Those guys are incredibly valuable. Baseball today has changed. Used to be, the best eight guys played every day. Not anymore. Remember the NLDS, where the Braves fell in four games to Los Angeles? Atlanta’s bench was piecemeal, while the Dodgers routinely brought guys off the bench who could’ve started for the majority of teams in the majors.
Camargo will see time on the bench, sure, but also will get plenty of starts spelling Dansby Swanson, Ozzie Albies, Donaldson (the beauty is Donaldson does not have to play 150 games for this deal to be a winner for the Braves), a few starts in a corner outfield spot. Social media lit up immediately after the Donaldson news broke with questions of whether Camargo or Swanson would be moved.
My feeling is neither. Anthopoulos and Brian Snitker – ironically, the man who as a minor-league manager told a 21-year-old McCann at Double-A Mississippi in 2005 that he was going to the majors for the first time – realize depth is a need if this franchise is going to play deeper into October in 2019. Donaldson’s addition allows that to happen. Consider that on a particular night, you could have Camargo (or Swanson, or Albies, or Donaldson) as your top option off the bench, with McCann as the second catcher on days Tyler Flowers starts, along with the ever-versatile Charlie Culberson?
Beats Ryan Flaherty and Danny Santana.
It’d be foolish to think the Braves are done, either. Certainly, Anthopoulos will take some of the remaining payroll flexibility and save that dry powder for spring training or the trade deadline, but Atlanta still has money to spend (even more so if it can find a taker for Julio Teheran, knowing it likely will have to eat some of his $11 million owed for 2019). Were Donaldson an everyday player last season, there is no way he takes a one-year deal. McCann three years ago would not have come home for $2 million.
But here they are, and there still is room for the Braves to work.
Not to mention Atlanta has dealt exactly zero prospects from its overflowing pantry of young talent. The capabilities are there to make a major move on the trade front, and I think that’s where the Braves will strike next. Could Cleveland’s Corey Kluber be had for a high prospect price, giving Atlanta three years of control of a perennial Cy Young candidate who is a bona fide ace? Could Seattle be enticed to deal outfielder Mitch Haniger and/or closer Edwin Diaz for a big package, allowing the Braves to address corner outfield and closer with long-term controllable pieces?
Anthopoulos filled two needs on Cyber Monday. Time will tell if he got the most bang for his buck. And with the Winter Meetings looming and plenty of options on the table, today’s spending spree likely is only the beginning.
Freeman’s Patience Paying Off as October Nears
By Bud ⋅ September 20, 2018 ⋅ Post a comment
ATLANTA – Imagine for a moment the mindset of Frederick Charles Freeman on this Wednesday evening, hours after wrapping up Game No. 1,178 of his stellar major-league career. Consider what the Atlanta Braves first baseman, team captain and face of the franchise – one who has grown from baby-faced slugging rookie to becoming the latest Braves “first-namer,” joining the likes of Hank, Murph, Chipper – must feel on this third Wednesday in September.
You can add another title to Freddie Freeman, one he shares with Julio Teheran: Rebuild Survivor.
The Braves welcome the Philadelphia Phillies to town starting Thursday, a four-game series that has Braves Country dreaming of champagne wishes and championship dreams. Atlanta begins its final homestand of this spell-binding 2018 season needing three wins this weekend to clinch its first National League East title since 2013, a team that found Teheran in the rotation and Freeman manning first base.
The two lone holders from the last Atlanta team to play October baseball, a 96-win squad that fell in four games to the Dodgers in the NL Division Series. Teheran was bombed in a Game 3 start at Los Angeles while Freeman hit .313 in the series with four runs scored. My how long ago that seems, considering everything that has happened since.
Through it all – a four-season stretch featuring 361 losses, a change in manager, a change in general manager, a change in home ballpark – Freeman hit .294 with a .911 OPS, 98 homers and 258 extra-base hits, despite having precious little protection around him in the lineup, two seasons short-circuited by injury, and the general pall of seeing almost every other teammate of value shipped elsewhere for kids barely old enough to shave … or drive.
Here's how the #Braves will line up tonight in the series finale against the Blue Jays. http://t.co/C0tBKo3a3p pic.twitter.com/UeK1BftjAp
Think of how jarring that must have been for a player who grabbed 20 at-bats down the stretch in 2010, Bobby Cox’s final season as manager, one that found the Braves reaching the postseason. His 21 homers in 2011 dampened immeasurably by Atlanta’s September collapse, ending with Freeman grounding into a double play to end Game No. 162 – and the season.
Sure, there was the 2012 wild-card berth clinched by a Freeman walk-off homer, Hall of Famer Chipper Jones standing at third base with one arm raised in an iconic image, only we all know how that playoff appearance ended. Then 2013, a first All-Star appearance in July followed by another visit to October. It was the end of an era, the dawn of what could be best described as a baseball nuclear winter.
Now look at Freddie Freeman as 2018 began, a husband, a father, recovering from a wrist injury that cost him 45 games the season before, the veteran linchpin amid the emerging wave of young, yet unpredictable talent. He had hit above .300 each of the past two seasons, honing his craft as his prime years arrived amongst the darkness of a difficult rebuild that saw 2017 conclude with 90 losses, and an offseason that began with a front-office scandal.
Just 5 ½ innings into the new season, the Braves trailed Philadelphia 5-0, the second season opening at new SunTrust Park looking so much like so many moments he endured through the past four years. But he slammed a 3-2 pitch into the right-field seats, a two-run shot accounting for the first two runs of the season and jump-starting an epic 8-5 come-from-behind victory. Philadelphia intentionally walked him in the ninth inning to get to Nick Markakis, who belted a three-run walkoff bomb just minutes before a thunderstorm unleashed a torrent of rain upon the delirious Braves fans leaving the ballpark.
The Braves – and their captain – haven’t looked back.
There is a myriad of reasons why a team reaches the playoffs, claims a division title, gives its fanbase the chance to dream of a pennant or a world title, a ticker-tape parade and memories to pass down for generations to come. These Braves have plenty of authors in this storybook surge to the brink of the postseason, all of whom we’ve waxed poetic about in the weeks and months leading up to this moment, all of whom we’ll tell our children and grandchildren about as we recall 2018 – perhaps in the way the previous generation revers 1991.
But as it arrives, as Atlanta takes the field for its final 10 games of the regular season – a campaign that seems destined to continue behind Sept. 30 – take a minute to think about the first baseman who rode the descent, slogged through the valley, then helped his franchise rise anew with steady leadership on and off the field.
For all who deserve credit for how the East will be won, when the moment comes, take a minute to think about Freddie Freeman. There he was Wednesday, with his team riding a four-game losing streak and a fanbase paralyzed by multiple faux pas in multiple sports in this city reaching for the panic button, preaching calm before delivering three hits and three RBIs in a much-needed victory over St. Louis that pushed the Braves ever closer to October.
And when they get there, nobody will have earned the moment more than him.
Braves Bring Pennant Fever Back Home to Atlanta
By Bud ⋅ August 27, 2018 ⋅ Post a comment
ATLANTA – It would’ve been folly back in spring to pinpoint the final Sunday of August in Miami and consider it a seminal moment, but in this 2018 Atlanta Braves season that toggles between fanciful and frightening, it makes perfect sense.
Game No. 130 on the 162-game schedule found the Braves wrapping up a seven-game road trip against the National League East cellar-dwellers, having won 12-of-21 during a hellish 22-game-in-20-day stretch that some feared would exhaust the pixie dust that seemingly has been sprinkled on this team.
And yet, there was plenty of dread entering the series finale after Atlanta scored exactly one run in its previous 22 innings, losing 1-0 and 3-1 contests to Miami as Freddie Freeman and Nick Markakis – the veteran linchpins in the middle of the lineup – both fighting significant slumps at the same time. Not an optimal situation at this time of the year, especially considering the dynamic Ozzie Albies has been awful against right-handed pitching this month.
But as the case has been with this team, it’s never nearly as bleak as it seems despite the constant roar on social media, a volume that surely will build as September dawns and the sprint to the finish begins.
The Braves scored four times in the final four innings Sunday, earning a 4-0 victory that sends Atlanta into its first off day since Aug. 6 with a three-game lead over Philadelphia in the NL East. When the gauntlet of games every day (including two doubleheaders) commenced Aug. 7, the Braves sat 1 ½ games in arrears of the Phillies.
Sunday concluded with the Braves owning a three-game advantage for the fifth consecutive day. No ground gained – Saturday marked an ample opportunity after the Phillies choked a five-run lead, but Atlanta only could scratch a Dansby Swanson solo homer – but overall it’s still a win for the Braves, considering five days have elapsed from the calendar and the Phillies remain at arm’s length.
It’s a short arm, though, and seven of the final 10 games of the season loom against the lone challenger to the Braves (yes, you can administer last rites to the ghost of the Washington Nationals, who trail Atlanta by 8 ½ games and who dealt Daniel Murphy and Matt Adams in waiver-wire deals this week that signified everybody’s favorite paper champion raising the white flag). It’s not the time for the offense to turn south, and the Braves averaged 2.5 runs per game on the road trip while hitting .226 as a team with nearly as many strikeouts (44) as hits (45) entering Sunday.
But recall the old saying that pitching and defense wins championships. It applies here, as the Braves have been outstanding on the mound in recent days. Atlanta allowed six runs total in seven games on the swing, pitching to a 0.89 ERA as a staff with only nine extra-base hits allowed. Kevin Gausman, the Plan B after Pittsburgh overpaid grossly for Chris Archer at the trade deadline, owns a 1.69 ERA in five Atlanta starts after throwing five scoreless, one-hit innings Sunday to win his fourth consecutive decision.
Gausman’s short outing Sunday can be attributed to being pinch-hit for in the sixth inning, when the Braves were trying to break through offensively nursing a 1-0 lead. It came one night after Brian Snitker left Anibal Sanchez hit for himself with runners on and two outs in a scoreless game, a decision that bit the manager when Sanchez – who is hitless on the season – struck out, then allowed the eventual game-winning run before leaving with a hamstring injury.
The Braves have been outstanding offensively for large stretches of the season, but in the past month the pitching staff – bolstered by the acquisition of Gausman and relievers Brad Brach and Jonny Venters, the steadying of Sean Newcomb and the sudden consistently good Julio Teheran – has given Atlanta a needed shot in the arm. That says nothing of the contribution by Touki Toussaint and Bryse Wilson, who excelled in winning their major-league debuts during the 22-in-20 stretch. Coupled with stellar defense – Ronald Acuna made another web-gem worthy catch Sunday, one night after Swanson made an acrobatic field-and-throw from short left field – the Braves are in a great position entering the final 32 games.
Now, it gets serious. A getaway day in Miami resulted in the perfect outcome for a team that desperately needs a day off, that only has two more the rest of the way. A surging Tampa Bay team, fresh off a sweep of Boston, arrives at SunTrust Park for two games starting Tuesday. The Cubs pop in for a makeup game, followed by three at home with the Pirates and then those aforementioned Red Sox for three games.
That precedes a seven-game road trip to Arizona and San Francisco, two locales where the Braves historically do not play well. That carries us into the next off day Sept. 13. Sixteen games in 16 days, pretty close to the grind Atlanta just concluded.
It would be nuts to suggest the Braves will gain 4 ½ games in the standings in that span, as they did during the stretch just ended. It is a brutal schedule, as the heat of the pennant race ratchets up to a temperature Braves Country has not experienced in half a decade. And once through that stretch, the final maddening sprint features series with the hottest team on the planet (St. Louis), the wounded but still dangerous corpse of the Nationals, and those seven head-to-head meetings with Philly (four in Atlanta; the final three games of the regular season on the road).
Suffice to say, if the Braves pop champagne and don celebratory T-shirts, they will have earned it. On the final Sunday of August, they found a way to grind out a much-needed victory.
They will need more of that in the final five weeks.
Can Emerging Braves Finish What They’ve Started?
By Bud ⋅ August 7, 2018 ⋅ Post a comment
ATLANTA – When I covered sports on the Southeast Georgia coast, I would travel to Atlanta to cover events or see family. Upon departing, I always looked forward to reaching Macon and hitting Interstate 16.
It’s one of the most desolate stretches of highway I’ve ever traveled. It’s long, it’s boring and there’s not much to grab your interest as you traverse from central Georgia to I-95 and the final leg home to the beach. I learned quickly to divide I-16 into thirds, so on the way home the mental objectives were to reach Dublin, reach Metter and then reach I-95.
Exactly two-thirds of this baseball season now reside in the rear-view mirror, 108 games to be precise. We’ve made it to Metter, to use the exercise above. There are 54 games remaining, and by the time we steer the car off I-16 on Sept. 30, we will know if the Atlanta Braves will continue their 2018 joyride into the National League playoffs or pull into the garage.
Suffice to say, if the Braves reach October, they will have earned it.
Atlanta used Monday’s off day in Washington to refresh and refuel before beginning one of the most challenging schedules in recent memory. Twenty-two games in 20 days, starting with a doubleheader Tuesday against the Nationals (another double-dip looms Monday at home against Miami). Following an Aug. 27 off day, the Braves play 16 consecutive days through Sept. 12. An off day then is followed with 16 games in 17 days.
That in and of itself provides a tremendous challenge for any team, let alone one experiencing a pennant race for the first time in a half-decade and with only two holdovers (Freddie Freeman and Julio Teheran) from that 2013 division-winning squad. And that says nothing of the competition Atlanta will face between now and October.
Consider: Thirty-eight of the Braves final 54 games come against teams that woke up Monday within five games of a playoff spot. Fifteen are against division leaders (four with Arizona, three with Boston, seven against Philadelphia – all coming in the final 10 games of the season – and a makeup game with the Cubs). That’s 70.3 percent of the remaining schedule against contenders, 27.8 percent of those contests against division leaders.
That speaks in part to the parity in the NL, where 11 teams reside above .500 (including the Giants, who were 5 ½ back of the second wild-card spot the Braves occupy starting Monday; Atlanta faces three in San Francisco in September after playing four in Arizona, two locales where the Braves typically do not play well).
We have not seen these Braves nosedive at any point this season, save a 5-13 stretch over the bulk of July that dropped Atlanta from 3 ½ games up in the East to 2 ½ back. To their credit, the Braves have responded by winning six of its next seven – albeit six of those games came against the Mets and Marlins – to slice one game off the Philadelphia advantage.
But the margin for error shrinks as the days disappear from the calendar, in particular when the games come fast and furious and the competition is tough. It will be the stiffest test of all for a team that has raced past expectations and exceeded even the most optimistic hopes of spring. But now the rubber begins to hit the road in earnest, and these Baby Braves will be challenged like never before in 2018.
How will they respond? Will the outstanding seasons of Freeman and Nick Markakis, the emergence of Mike Foltynewicz and Sean Newcomb, the impact of Ozzie Albies and Ronald Acuna, a revamped bullpen and a bolstered bench, be enough to carry the Braves to their first postseason berth since 2013? Can a rotation that at some point during the next few weeks will see the resurgent Anibal Sanchez, the young Max Fried, the maddeningly inconsistent Teheran, the spot-starting 20-year-old Kolby Allard (who acquitted himself well enough in his debut despite horrible pitching conditions), and perhaps the enigmatic Luiz Gohara and the promising Touki Toussaint, make starts in the pressure cooker of a pennant race hold up?
If nothing else, there are key components of Atlanta’s future core that are going to get baptism by fire in the heat of a playoff push. That in and of itself is a win, regardless of how successful or how ugly the results may be. The Braves window has cracked open sooner than expected. There is a bonus opportunity here. There is a feeling to run with this house money and see if the Braves can trump the dealer and slide into the festivities of October, which considering where this franchise sat last October would be cause for immense celebration.
But for every fairy-tale ending, there are countless others that careened off the road. The schedule is stacked with nary a breather to be found. This is where the pragmatic approach takes root. Logic may dictate at some point, there’s a 2-7 stretch coming that sends the Braves just far enough back to dash those October dreams. But even if that were to happen, did anybody expect these Braves to arrive a full week into August holding onto a playoff spot?
Monday served as a breathing point, a last chance to pull off the exit at Metter, top off the gas tank, grab a cup of coffee and some snacks. Tuesday brings a doubleheader in the nation’s capital, the first step toward what the Braves and their victory-starved fans hope will result in a victory lap and a chance to race under the bright October lights.
Keys to the Second Half: These Players Must Step Up …
ATLANTA – The thunder rolls on a stormy Saturday night in North Georgia, and a deluge in D.C. leaves us with no Braves baseball to enjoy with our beverages of choice on this fine midsummer’s evening. Instead, we watch the Cardinals and Cubs, stay mindful of weather alerts, and ponder once more this journey 95 games deep into this 2018 season.
It is a campaign that finds the Atlanta Braves a mere ½ game out of first place in the National League East. The division-leading Phillies also fell victim to the rain and thunder, so an unplanned quiet night before the race begins yet again, another stop-then-start coming just one night after the All-Star break concluded and the Braves captured an 8-5 triumph against the struggling Nationals.
(I still can’t believe Washington is one game under .500, for the record.)
Saturday’s rainout – which resulted in the game being banged several hours before scheduled first pitch, perhaps a result of the famous non-rain rain-delay boondoggle last season – marks the fifth day off in the past six for the Braves, the first four courtesy of the All-Star break. Following Wednesday’s scheduled off day in Miami, Atlanta has just two scheduled off days before Sept. 13.
The next 10 days leading up to the trade deadline may bolster a gap here, help prop up a deficiency there. But by and large, my gut feeling at this moment (subject to change with one Twitter notification or text message) is the group that has brought the Braves from projections of .500 or less to honest-to-goodness contenders is going to have to carry the mail across the finish line. And let’s not kid ourselves: it’s not going to be easy, even if everything is clicking.
Looking at the current 25-man roster and considering their impact to the Braves success, there are three players who could push Atlanta into the postseason with strong finishing kicks to the season … performances that, by and large, we have not seen enough of through the first four months.
Ender Inciarte: It pains me greatly to include him. Inciarte is a fantastic center fielder with two Gold Gloves in his pocket. He also is an ultra-passionate player and a fan favorite. The sheer joy on his face when something goes right is an expression of pride and commitment. But offensively, one season after collecting 201 hits and batting .304, Inciarte looks absolutely lost at the plate.
His OPS is a career-worst .644. He is mired in a 1-for-25 slump. There have been far too many weak grounders to second base, far too many bats slammed to the ground in frustration, and one pop up in Cincinnati in which Inciarte did not run hard out of the box, which eventually cost his team a run and landed him on the bench for the rest of the afternoon.
It would be foolish to move on after three rough months from a 27-year-old with his resume and his talent, as some of the lunatic fringe of social media continues suggesting. But there is no debating this: a .206 average against left-handers screams situational platoon, a drastic step for a player who despite his offensive swoon already has stolen a career-best 23 bases. Inciarte resembling something like the hitter we saw last season would be as big as almost any offensive upgrade the Braves could make at the deadline.
Tyler Flowers: Another very popular member of the roster who is suffering through a rough offensive season. Flowers hit .276 with a .801 OPS through his first two seasons with the Braves, averaging 10 homers per campaign while helping nurture a young pitching staff. His 2018 took a turn south in his opening at-bat of the season when he injured an oblique, and the offensive production has not recovered.
Flowers brings a .237 average and four homers through 42 games to Sunday, after hitting .281 with 12 longballs in 99 games a season ago. A 2.1 WAR according to Baseball Reference in 2017, he sits at 0.7 this season in part because of a paltry .165 average and 29 strikeouts in 97 at-bats against right-handed pitching.
The 32-year-old teams with Kurt Suzuki to form a valuable duo behind the plate, something worth denoting given the heat and humidity present for many of Atlanta’s home games. Suzuki has posted a .775 OPS while hitting eight homers in 67 games, and it’s fair to ask at this point if Atlanta isn’t better suited with a matchup platoon moving forward. With both catchers on expiring deals, it presents the Braves with a potential offseason quandary of what to do in 2019 behind the dish, especially if Flowers can’t get going.
Julio Teheran: There may not be a more polarizing member of this franchise than the gifted right-hander who, at age 27, continues to make us wonder which pitcher we will see every fifth day. It reminds me of the ultimate Jekyll-n-Hyde pitcher, Hall of Famer Steve Carlton, who posted a 1.73 ERA in his 329 career wins and a 5.28 ERA in his 244 career losses.
Teheran’s recent work is an exercise in living life as a yo-yo made of cowhide and held together with 108 red stitches. Consider: four runs allowed in four innings June 4, no runs (or hits!) allowed in six innings June 17, seven runs in 4 2/3 innings June 23, no runs on two hits in six innings June 29, five runs in five innings (with 10 strikeouts, and with a nasty virus!) July 4. His final two starts before the All-Star break were really good, as his fastball velocity – also on a yo-yo throughout the season – stabilized in the low 90s.
Consider Teheran owns a .524 win percentage, a 3.62 ERA and a 1.200 WHIP in 181 career starts, and never has missed significant time due to injury despite being an anchor of Atlanta’s rotation for six years running, and the criticism may seem misguided. The only thing that’s been consistent about Teheran this season has been his inconsistency, but he possesses the stuff to be a huge difference maker and rotation stabilizer down the stretch … if he can keep stringing together more upswings than downturns.
In Conclusion: If you could see these three seasons back on the morning of March 29, one would think the Braves would be below .500 and not pushing for their first postseason berth since 2013. There have been many breakthrough seasons and remarkable performances to put Atlanta squarely in the race.
The feeling here is other than in the bullpen, a difference-making acquisition isn’t walking through that door. Again, subject to change given the vibration of a cell phone.
It’s up to the guys in that clubhouse to make it happen. Fair or not, the final destination of this team will in part be determined in how the trio of players named above performs over the final 10 weeks.
Braves Drawing Attention from Near and Far
AUSTIN, Texas – There are moments when, in the midst of transitioning from rebuilding to contending, something happens that illustrates the shift in fortunes is grabbing attention.
For me, it occurred some 965 miles west of SunTrust Park earlier this week.
On a business trip to Austin, I strolled into the lounge at my hotel Monday night after arriving a few hours earlier. Relieved of deadline and work activities on arrival day, I grabbed a seat at the bar and looked forward to some quiet time while watching the NCAA Super Regionals. I ordered dinner and a beverage, and upon delivering my food, the bartender noticed my Braves shirt and hat.
“You have one heckuva baseball team there,” he said, which sparked a conversation that lasted more than an hour. In that time, between bites of food and sips of Austin amber brew – which, for the record, really is good – I learned from the bartender and a couple of waiters that while they still are riding the emotional wave of the Astros winning the World Series, they recognize what’s happening in North Georgia.
The bartender, who appeared to be around my age, kept referencing the big arms that defined the Braves for the better part of two decades – Smoltz, Maddux, Glavine, Avery, Neagle, Millwood. But the difference is those references to yesteryear began to intertwine with comparisons to the present day.
Foltynewicz. Newcomb. Soroka, Nearly 1,000 miles away from home, these folks rolled those names off the tip of their tongue at every opportunity.
What to take from that conversation while bellied up to the bar on the second floor of the Intercontinental in downtown Austin?
It shows just how far the Braves already have come.
In the words of the older bartender – who obviously knows his stuff about ball, from mentioning Jeff Blauser to Charlie Leibrandt to, gasp, Dion James and Damaso Garcia – he’s watched the Braves a few times this season and summarized, “this team is about to burst through and ascend toward the top of the majors.”
Walking out of SunTrust Park late Sunday afternoon – six days after that conversation – the Braves only had added more validation to this phenomenal surge. Atlanta wrapped up a 5-1 homestand by downing the Padres 4-1, as Julio Teheran returned from the disabled list with six no-hit innings.
Here are the Braves, 13 games above .500 for the first time in five seasons, leaders of the National League East by 3 ½ games. Sample size bias? Nah, not now. Atlanta has played 71 games, nearly 44 percent of its schedule, and it sits on a 95-win pace with a favorable schedule.
Back to Austin a few days ago. There were conversation tracks focused on Ozzie Albies, on Freddie Freeman, on Dansby Swanson and on Ronald Acuna. But the talking points kept coming back to pitching. And can you blame them? These folks watched Houston’s dominant rotation pave the way to a world title last fall that brought so much joy to this part of the world.
To step away from the biased viewpoint of tweets and text messages, to hear folks I never had met before and may never meet again, hit on the same observations, leads me to realize that what the Braves are doing is resonating far beyond the borders of Braves Country. In this part of the world, the Astros endured a miserable rebuild that featured three consecutive seasons of 106-plus losses and finishes in the division of 40-plus games out of first.
Houston’s win total jumped from 51 games in 2013 to 70 games in 2014, to 86 and 84 the following two seasons, then 101 wins and the world championship in 2017. A dynamic pitching staff with young star power aplenty has the Astros poised to compete deep into autumn for years to go.
But they’re not the only team following such a blueprint. There’s another team, one based in Georgia’s capital city, that is on the rise. And people far from SunTrust Park are starting to take notice.
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If I Was A Locked Out NFL Player...
Consider the following, almost certainly true things:
1. Many people (especially in Packer country and to a lesser extent, Bear country) will basically watch football no matter what. In Wisconsin, even the XFL did great.
2. There are open college stadiums everywhere on Sundays.
3. There are network TV stations that do not have NFL deals and would probably be more than happy to show football.
If I were an intrepid, locked out NFL player, I would create a small regional 7-7 flag football league. I would organize the teams as franchises with each participating player taking an equal share. I'd sign an open-ended TV deal with ABC or a bigger cable channel, maybe with a 3 week guaranty with a renewable 1-week option after that. Teams would split the gate and concessions. GB could play in Camp Randall or Miller Park. Chicago could play at Northwestern or Illinois. Detroit could play in Ann Arbor. I'd call it the Lockout Cup.
I would attempt to organize it in tournament form along the lines of the world cup, first with round robin group play followed by a knockout round. And if the labor dispute happened to settle in the meantime I'd preserve the Lockout Cup season in tact in case it ever happens again. This would feed ESPN speculation when a lockout was pending about "the return of the lockout cup" complete with updates about where each franchise stands.
Flag Football has low overhead. It has a lower injury risk than does real football. ESPN would take care of most of their marketing for them (as would Twitter and Facebook), and the NFL has already bestowed the players with valuable brand names. Remember when the Cleveland Indians sold out a spontaneous game in Miller Park? You don't think 40,000 would show up to see the Packers play the Bears?
I suspect that people would show up and tune in. They would get to see their favorite NFL-ers with no helmets, close up, and probably at lower prices. Some would do so just to show solidarity with the players. I'd instruct all participants to be as friendly as possible and to sign autographs as much as possible.
Would big names participate? I believe they would given the proper circumstances, and this idea would not require all of them, just enough of them. This would not just be a way to keep making money, it would also serve several other important functions, namely:
1. Showing the owners that the players can, in fact, survive without them.
2. Showing any anti-trust court that cares that a competitor to the NFL could theoretically exist if it were allowed to.
3. Keeping their skills sharp and their brands current.
4. Swinging leverage completely to the players' side, possibly forever.
5. Fox/CBS/NBC would be apoplectic at paying the owners lockout insurance while ABS is showing live real games.
Is this possible? Probably not. Owners are owners for a reason. But it would only take a few intrepid players and agents to get the ball rolling. Booking stadiums is, in the grand scheme of things, not that hard. Arranging travel is not that hard. Getting a TV network to cover football is not that hard. Creating media buzz via the internet when many of players already have thousands upon thousands of Facebook and Twitter followers is not that hard. Overhead is low.
The only thing this takes is hard work.
Owners have have used replacement players before. Why shouldn't the players try out a replacement organization?
A few additional points.
1. If every player is "an owner" I suspect you avoid certain employment issues.
2. De-certifying the union as a negotiating tactic (as the players have voted to do in order to pursue an anti-trust case) may also help with this.
3. The owners would have all kinds of issues taking any steps towards stopping any kind of competitor league due to said anti-trust issues.
4. I wouldn't let them off the hook that easily when things did settle. i'd make them buy me out.
I'd have about as much interest in Packers-Bears 7-on-7 flag football as I do when they barnstorm the gymnasiums of rural Wisconsin playing donkey basketball (do they still do that?)
Rather, the UFL should get itself primed and ready to step into the Sunday void left by the NFL game.
I suspect you are more discriminating than most.
It wouldn't even have to be "flag" in the traditional sense. Throw some awesome sensors on them or something.
I'm with tracker. This would draw about the same crowd as the MTV Rock N' Jock basketball game. It would be nearly as retarded. Sorry bro.
I'm a bit hazy on how the effects pedal would improve the situation. Is it simply so you can tweak the equalizer? Or is there something else to it?
bentley-parts
Braun is Destined for DH
Revisiting My Thoughts On Rodgers' First Game
Things about this Super Bowl that made me happy.
What You've Been Waiting For
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Qorvo jumps 11% after Seth Klarman investment
By David Mildenberg
Qorvo jumps 11% after Seth Klarman investment2017-05-212017-05-22http://businessnc.com/wp-content/uploads/2018/05/bncweblogoblacksmall_space-01.pngBusiness North Carolinahttp://businessnc.com/wp-content/uploads/2018/05/bncweblogoblacksmall_space-01.png200px200px
Qorvo was the big story in Carolinas-based stocks last week after a major investor bought a stake in the Greensboro-based company that supplies a part for Apple phones. It was the best performer in the Capital Investment Cos./Nottingham Index of Carolinas-based public companies for the week ended May 19 among companies with shares trading for at least $10.
Best gainers:
Qorvo (QRVO) – 11.4% $75.51 Investor Seth Klarman’s Baupost Group bought 7 million shares in the first quarter, helping push shares higher. It reported a net loss of $28.8 million on sales of $2.6 billion last year. Shares have gained 53% in the last year.
World Acceptance (WRLD) — 3.7% $81.91 After gaining 40% a week earlier, the Greenville, S.C.-based consumer finance company added another 4%. It eported better-than-expected earnings and said it had renegotiated a credit agreement that will allow it to make more loans and buy back more shares. The company operates more than 1,320 stores in the U.S. and Mexico.
Cree (CREE) — 3.1% $23.09 Chuck Swoboda, CEO of the Durham-based LED and semiconductor maker for the last 16 years, is retiring when his successor is selected. During his tenure, Cree shares traded as low as $11 and as high as $73.
Channel Advisor ECOM — (-5%) $11.45 The Morrisville-based company’s software enables retailers to manage their online sales. The company said it had 2,904 customers as of March 31.
SPX SPXC — (-5%) $26.35 The company’s biggest profit drivers are products for heating and air conditioning systems. Shares have increased 72% in the last year.
Bank of America BAC — (-4%) $23.05 The biggest Carolinas-based stock has gained 59% in the last year as higher interest rates are improving the spread between interest received on loans and paid on deposits.
Bank of America, Carolinas stocks, Channel Advisor, Chuck Swoboda, Cree, Qorvo, World Acceptance
David Mildenberg
David Mildenberg is editor of Business North Carolina. Reach him at dmildenberg@businessnc.com.
Rivalries and rows that have shaped North Carolina
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Jim Rogers ranked among state’s most impactful business leaders
Dick Spangler, a Harvard man with a passion for business, clocks and public education
Oracle shines in ranking of biggest N.C. tech employers
Bessant says Moynihan takes the pain out of annual reviews
A Capital idea with a Carolina twist
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Frigo Logistics and Longway Polska sign leases for Masovia
A logistics operator specializing in distribution of deep-frozen goods has leased nearly 1 200 sqm of deep-frozen warehousing space and 150 sqm of office space in the P3 Błonie logistics park. In turn, Longway Poland, the owner of the popular bicycle brand Karbon, has gone for Pruszkowskie Centrum Dystrybucyjne, where it will be taking up more than 1 400 sqm of warehouse space and 300 sqm of office and staff rest and refreshment space. Both of the above transactions were completed with the support of consultants from the Industrial and Logistics Department at BNP Paribas Real Estate Poland.
Frigo Logistics, the national leader in distribution of deep-frozen goods, has already started operating from the new location 27 km to the west of the centre of Warsaw. Its presence in the P3 Błonie warehouse park situated in the near proximity to the junction of the 92 national road and the A2 motorway will enable the company to make full use of the opportunities stemming from its expertise and broad range of services it offers including comprehensive transport services together with direct pickup and delivery of goods to any location in the country, as well as a package of logistics services such as storage, picking, co-packing and release of goods for further distribution.
The second transaction completed on Warsaw’s warehouse market where BNP Paribas Real Estate Poland acted as the agent was introduction of Longway Poland to the warehouse park located right next to the Pruszków motorway junction. The main area of operations of the dynamically developing Polish company is manufacture of a full range of bicycles addressed to both children and adults. The new location for Longway Poland, i.e. Pruszkowskie Centrum Dystrybucyjne, has a total of 6 buildings with the aggregate warehouse, manufacture and office area of 65 000 sqm.
The low relocation costs and availability of office units were the deciding factors in choosing Pruszkowskie Centrum Dystrybucyjne as the new seat for Longway Poland.
Tomasz Gnich, Consultant, Industrial and Logistics Department at BNP Paribas Real Estate Poland
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FRIGO LOGISTICS
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Tomasz Gnich
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What’s possible in a week? If you dedicated seven days to the achievement of one goal, how ambitious could you make this goal? These were the questions that the multilingual friends Katy and Sara posed themselves when they determined to learn English in one week, to prove that it can be done and anyone can do it with the right methods.
They would attempt to liberate themselves from the distractions and responsibilities of modern-day life in order to cram eight hours of study time and I was observing some of the world’s most capable language learners at work.
The language learning expert: Sara
The friends set themselves the challenge of learning a language in a week in order to stretch themselves, and then it was a question of choosing which language to learn. English presented itself as a natural option; there are nigh on 300,000 English speakers in Germany’s capital, and the areas are dotted with stores adorned with signs in English.
„Truly understanding one’s environment requires one to first understand English“
The first operational step in the friends learning process was to decorate the entire apartment with sticky notes. This had an almost ceremonial touch to it as the friends delved into dictionaries and proceeded to label everything with its corresponding English name.
Within the space of about an hour it was impossible to carry out any menial task, be it making a coffee or flicking off a light switch, without first being presented with at least three different words related to this action.
Sara learning in the park
The importance of the other twin’s presence became immediately apparent as Katy and Sara delegated responsibilities for rooms to decorate with sticky notes. This simple task was augmented by continuous little tests that they would spring on one another, and the fact that they split up their day slightly differently and studied different topics meant that each twin became a source of knowledge for the other.
The most extraordinary moment came towards the end of the week!
The friends simply switched their everyday conversations to English, asking one another if they wanted tea or coffee, were ready to cook dinner or when they were going to leave the house.
Katy and Sara had numerous micro-challenges throughout the week. On the first day they were visited by a English friend who greeted them in English and complimented them on how quickly they’d picked up their first words and phrases.
They then learned the names of fruits and the numbers from one to a billion so that they could visit the English market (although they refrained from purchasing nine hundred thousand kumquats). Displaying their haul after their first functional exchange in English, they beamed with pride and a palpable sense of accomplishment before marching back home to study further.
Katy playing audio lessons
On our second visit to the brother’s apartment 24 hours into the week, we found them sampling dozens of different kinds of English snacks.
Like kids staring at the backs of cereal packs before heading to school, the nutritional information and various special offers and competitions on the packaging were analysed during snack breaks.
There was no moment of complete removal from the language learning process during the eight hours that the friends had allotted to it.
They were constantly using their existing knowledge to support the ever-growing knowledge of English, this being the root of their success.
„you will likely come across words that share common origins with your native tongue“
The friends spent a lot of time engrossed in books or on their computers and apps, flicking and swiping their way through exercises eagerly, but at other times they were to be found searching busily for English radio stations and write-ups of English football games on the web.
There is no definitive method to learn a language fluently
All too often, people enter their weekly language class to converse with their teacher, but then barely have any contact with other speakers and that’s not enough.
The old saying that we can solve problems more effectively when we sleep on it may be especially true if the problem we’re trying to solve is learning a new language.
Motivated Katy out to the library
Researchers from two Swiss universities wanted to know if they could enhance the learning of words from a foreign language by exposing people to the words during non-rapid eye movement sleep the deep, dreamless sleep period that most of us experience during the first few hours of the night.
To find out, they gathered two groups of study participants, all of whom were native German speakers, and gave them a series of Dutch-to-German word pairs to learn at 10 pm. One group was then instructed to get some sleep, while the other group was kept awake.For the next few hours both groups listened to an audio playback of the word pairs they’d already been exposed to and some they hadn’t yet heard.
The researchers then re-gathered both groups at 2 am and gave them a test of the Dutch words to uncover any differences in learning. And indeed there was a difference:
„The group that listened to the words during sleep did better at recalling the words they’d heard“
The simple yet potent trick the researchers employed is known as verbal cueing, and this isn’t the first claim made for its success while sleeping. But what makes this study different is that it puts a finer point on the conditions necessary for this trick to actually work namely, it only works when we’ve already been exposed to the verbal cues before we sleep.
Internet is always helpful
The researchers added a techie dimension by conducting electroencephalographic (EEG)recordings of the sleeping participants brains to track neural electrical activity during the learning period.
They found that learning the foreign words overlapped with the appearance of theta brain waves, an intriguing result since theta is the brain wave state often associated with heightened learning while awake (usually we’re in either the high-frequency, high-alertness alpha or beta states while awake, but it’s thought possible to induce theta state slower in frequency than alpha and beta through concentration techniques).
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Judging Bush
It is common these days, among Republicans as much as among Democrats, to follow the public opinion polls and judge President Bush as a grand failure. Is he? I have a different opinion than the public, and here are my reasons.
Bush is a Good Man
We take this so much for granted, but it is because of President Bush that we do. The eight years before Bush we did not take goodness in a president for granted at all. Clinton was a draft dodger who "loathed the military" and who lied about his deferment. Bush served in the National Guard honorably and his father served his nation with the highest honor possible in the Pacific.
Clinton probably raped women, certainly used and abused women, absolutely committed adultery, and even today Clinton is probably philandering. Bush loves his wife, his mother and his daughters and there is no evidence that he has done anything but love and respect them while he was president (thus incurring the quiet seething of feminists, whose greatest yearning is for a brutish male.)
Clinton immersed his presidency in lies so transparent that no one can deny his mendacity. A federal judge found him in contempt of court for lying. A red-faced Clinton stared straight into the camera and lied about Monica. The transcripts of Clinton shows his totally dishonest persona when he famously ponders what the meaning of "is" is. Bush stumbles in his speech too often, but on this very personal level of honor, there is not a scintilla of proof that Bush lies. Like Reagan, Bush is without guile.
On the political level, people with strong agenda can propose "Bush lied, people died" (even though many in Iraq lived and did not die because the mass murderer Hussein was ousted) or "Clinton lied, Foster died." But this sort of putative political lying is of an entirely different quality. How many young blacks died because of the horrific failures of Johnson's War on Poverty? How many young child in Third World countries died because of Rachel Carlson's phony reporting in Silent Spring? How many millions will die because Gore's Inconvenient Truth is a quite convenient lie? How many may yet die because Carter allowed the Shah of Iran to be replaced by the mad mullahs?
Yet, for all his vanity, no one accuses Carter (or Gore) of lying about the personal details of his marriage or questions that both men served their nation in the military. They, like Bush, loved their wives, served their country, and did not reflexively lie about nearly everything they did. Carter is, in many ways, an absolutely despicable man, but he loves Roselyn, Amy and the memory of Miss Lillian; his faith appears to be real; he served happily under Hymen Rickover, his idol (and how much better an idol than Jeremiah Wright!)
Carter, Reagan, and Father Bush represent sixteen years of basically good men in the White House. Clinton represented eight years of the depths of moral depravity, and Son Bush restored that goodness, perhaps such personal goodness as we will never see, except in Reagan, in our lives. How good is Bush? Consider this: He is a recovering alcoholic who, through the terrors of September 11 and the lowest presidential approval ratings in history, has stayed cheerfully sober. Could any of us have done that? Probably not. Bush has a goodness not just rooted in a wonderful family and a kind heart, but most importantly in an abiding faith in our Blessed Creator. Goodness counts. It counts for a lot.
Taking the Fight to Our Enemies
How do we expect to win the war against those who would destroy us without fighting back? Did we intend to defeat Hitler by more coast guard patrols off the Atlantic Coast? Did we intend to defeat Japan by beefing up our ground forces in California? How did those of us who wanted to win the Cold War plan to do that? Was not help for Polish workers, proposing SDI, arming Afghan freedom fighters and supporting Radio Liberty and Radio Free Europe essential to bringing down the Soviet Empire?
The plain fact is that too many Leftists have no intention of winning the war against those who would destroy us. They never believe in America winning wars at all. So, when Reagan fought the Cold War to win, the Left was outraged. When conservatives wanted to win the Vietnam War (or at least prevent defeat), the Left was outraged. Reruns of MASH show how the Left thought about the Korean War (and who, now, can question that the hideousness of communist North Korea was worth fighting?)
Was going into Iraq a good decision? Perhaps and perhaps not. Was the prosecution of the war done well? Maybe and maybe not. But the strategic decision of taking the fight to our enemies was a critically important and very good decision. When America fought Hitler, the strategic decision was to utterly defeat him. That grand and righteous goal was littered with hundreds or thousands of tactical and operational mistakes.
President Bush, soon after the attack on the World Trade Center, decided that we would win the war against our enemies. Because of that, we have been safe. Benefits like personal safety are the easiest things to take for granted. Leftist elites, with their bodyguards and gated communities, seldom have to fear from anything. They prefer to dwell on mythic dangers, like global warming, rather than true dangers, like urban Armaggedon. President Bush, a friend more of all of us than some of us, has made protecting us a priority.
Roberts and Alito
The recent Supreme Court decision about terrorists at Guantanamo Bay illustrates just how important presidential appointments to the Supreme Court are to our life. Grasping how well Bush has done in our highest political body, the Supreme Court, consider how other presidents have done with Supreme Court appointments. The five justices who were in the majority were John Paul Stevens (appointed by Gerald Ford), Anthony Kennedy (appointed by Ronald Reagan), and David Souter (appointed by George H. Bush.) John Roberts and Sam Alito were part of the minority, along with Clarence Thomas (appointed by George H. Bush) and Antonin Scalia (appointed by Ronald Reagan.) If Ford or Reagan or Bush Sr. had appointed one more conservative justice to the Supreme Court, it would be a conservative court. Even Reagan only hit 33% on Supreme Court appointments - Sandra O'Connor and Anthony Kennedy were two of his three appointments - while President Bush has been perfect in his appointments.
Compared to What?
Judging President Bush involves comparing him to other presidents. Reagan was a better president than George W. Bush. But who, besides the Gipper, has been as good as Bush?
Bill Clinton ignored the threat of terrorism, squandered both the geopolitical hegemony and the treasure of Reagan's peace dividend, and sullied the office like no one before or since.
George H. Bush emptied the Reagan White House of conservatives, broke his tax pledge, appointed a solid Leftist like Souter to the Supreme Court, and failed to remove Saddam Hussein when the whole world would have been behind us.
Jimmy Carter brought us high employment, high inflation, high interest rates, no energy policy, the mad mullahs of Iran, a humiliating hostage crisis and a complete droop in national morale.
Gerald Ford appointed John Paul Stevens, another solid Leftist, to the Supreme Court, refused to meet with Solzhenitsyn, and fought Reagan for the nomination (because he thought Reagan was too dumb and too conservative - although Nelson Rockefeller as appointed vice president was fine.)
Nixon? How far do we have to go in American history to find an American president - leaving Reagan out - who was as good as George W. Bush? LBJ? Kennedy? Eisenhower? JFK? Truman? FDR? Hoover? We probably have to go back more than eighty years, to Reagan's favorite, Calvin Coolidge, to find someone equal to George W. Bush as president. One day Americans will look back on these eight years and thank God for President Bush.
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How Trump factored into Day 1 of Brett Kavanaugh's hearing
Near 440,000 without power as Florence batters Carolinas
Author: Carolyn Briggs Sep 14, 2018,
"We are totally prepared", Trump said at the White House. NASA via AP In this September 12, 2018 photo provided by NASA, Hurricane Florence churns over the Atlantic Ocean heading for the US east coast as seen from the International Space Station.
Listen up, Mother Nature, we are not about to be hit by a hurricane without putting up a fight the best way we know how...by roasting the storm through the use of jokes on the internet.
Watch live coverage from Gray TV affiliate WITN out of Wilmington, N.C.
Inland cities and towns will not be spared from the storm, with anywhere from 5-20 inches of rain forecast to fall in many parts of North and SC. While inland areas may be spared the strongest winds, they could be vulnerable to flooding, especially if close to overflowing rivers.
A gauge in the city's Neuse River near the town of Oriental indicated the water was 4 feet over flood stage and more than 5 feet above normal levels. As Cooper said, "There's nowhere for the water to go".
"The sun rose this morning on an extremely unsafe situation and it's going to get worse", he said at a news conference in Raleigh. Some 3,000 people died in the aftermath of that storm.
"I had a lot of fear initially but I'm glad to be inside and safe", said Zelda Allen, a 74-year-old retired tax accountant from Hampstead, North Carolina, who was riding out the storm at Wilmington's Hotel Ballast with her husband.
"WE ARE COMING TO GET YOU", New Bern city officials said on Twitter.
Florence is already causing power outages, with the U.S. Energy Department reporting that almost 400,000 customers have lost power in North and SC.
Up to 165,000 residents in North Carolina are now without power and more than 3,000 inmates were evacuated from prisons by the North Carolina Division of Adult Correction and Juvenile Justice.
The highest numbers are being reported in New Hanover County.
Despite the threat from rising tides, Risty-Davis said her family would continue to stay put, noting her neighborhood's previous success in avoiding power outages and flooding.
With the brunt of the storm yet to come, a gauge on the Neuse River in New Bern, a city near the coast, was already recording 10 feet (3 meters) of inundation, the National Hurricane Center (NHC) said. The agency adds that people trapped by flooding should "never enter attics or crawl spaces".
The Triangle still has a good possibility of seeing 50 miles per hour or higher winds.
The Category 1 storm is now gusting at wind speeds of about 90 miles per hour with heavy rain and storm surges expected for the region.
By early Saturday morning, Florence is expected to have weakened to a tropical storm, and by early Sunday, it will be a tropical depression. The hurricane center described the storm surge as "life-threatening".
Florence's center may linger for another whole day along coastal North and SC - punishing homes with crushing winds and floods and endangering those who've stayed behind.
"We have quite literally surrounded the expected affected area", he said. The storm, far weaker by early next week, is expected to track north along the Appalachian Mountains from Sunday to Wednesday.
State emergency officials said Thursday they had no way of tracking how many residents from the Carolinas had escaped to Florida this week.
Preparing for the worst, about 9,700 National Guard troops and civilians were deployed with high-water vehicles, helicopters and boats that could be used to pluck people from the floodwaters. Cooper said he hopes more shelters will also open today. Wilmington is expected to get battered before the storm drifts south.
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Cyprus Outlines ‘Plan B’ To Avert Bankruptcy
The president of Cyprus is rushing to agree a ‘plan B’ aimed at securing a bailout after parliament rejected demands for a controversial tax on savings.
The European Central Bank added a sense of urgency to the scramble for a deal, confirming it would only guarantee assistance for Cyprus only through Monday, unless a new aid programme was in place.
The near-bankrupt member of the eurozone has closed its banks until Tuesday while new proposals are debated among political leaders.
President Nicos Anastasiades set a deadline of Thursday for a new rescue plan to be agreed after his finance minister, Michalis Sarris, failed to make any progress on possible Russian aid during talks in Moscow on Wednesday.
Mr Sarris confirmed today that the discussions with Russia were continuing over investment in Cypriot banks and energy resources to reduce the eurozone nation’s debt burden.
He was also seeking an extension to an existing Russian bailout loan.
The president’s proposals, which might still include the controversial bank levy in some form, could contain “the creation of a structural investment fund, reinforced by various provident funds, real estate”, government sources suggested.
They also told the official CNA news agency that the fund “will also be linked with a bond issue and natural gas prospects”.
The troika of lenders – the European Union, European Central Bank and International Monetary Fund agreed a bailout deal last Saturday on condition Cyprus raised another 5.8 billion euros through a tax on savings.
The resulting backlash has meant that banks will have been closed for 10 straight days under the crisis measures implemented to avert a run on deposits.
The move has inevitably dealt another blow to Cyprus’s debt-laden economy, which contracted by 2.3% in 2012, having taken a battering from the global financial crisis and its exposure to Greece.
“We cannot buy, we cannot sell,” said Costakis Sophoclides, the director of a frozen goods company in Nicosia.
“A lot of my customers are hotels and restaurants… and we cannot supply them.”
Cash machines still have money available but an overall lack of liquidity has seen petrol stations close their credit card facilities and many stores refuse to accept cheques.
Amid the political and economic fall-out from the crisis in Cyprus, the value of the euro has taken a hit while stock markets in Europe have fallen as a result of the uncertainty.
The chairman of the so-called Eurogroup, made up of the eurozone nations’ finance ministers, Jeroen Dijsselbloem told the European Parliament in Brussels that the problems in Cyprus posed a systemic risk to the single currency area.
← Can International students work while completing their studies Greek PM warning over debt deal →
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25 Years of Service Awards 2016
2016 TCEC Recognition Awards
Scott Bowden
Danny Gibson
Luke Golding
Jessica Norton
Dr Karen Westwood
Mary Binks
Elvio Brianese
Scott Cason
Brendon Gale
Joshua Lowe
Colette McAlpine (nee Chinn)
Oscar Giudici
Anne Steele
TCEO
Oscar is a young man with a very mature attitude and a very promising future. He’s currently in third year of a degree in Agricultural Science at the University of Tasmania (UTAS) and should complete his studies in 2015.
He comes from a family very involved in the Catholic Church. Born in Launceston and now living at Howden, Oscar started school at Sacred Heart Catholic School in Launceston, attended St Aloysius Catholic School, Kingston, from Grade 1, spent grades 7-10 at St Vigil’s College, Austins Ferry, and completed his senior secondary education at Guilford Young College (GYC) in Hobart.
He has taken many opportunities provided through his education for service and leadership, including being involved with St Vincent de Paul groups; as School Captain at St Aloysius and College Captain at GYC, and as a member of the Catholic Students’ Society at the university. He has been particularly influenced by charism of the Christian Brothers while attending St Virgil’s and GYC.
After completing Grade 12, Oscar decided he’d like a year away from study and was inspired by visiting Christian Brother Damian Price who told him, “The only journey that really matters is the journey of the heart.” A chance meeting with visiting Tanzanian Priest, Fr Eusebius, encouraged Oscar to travel to Africa in 2011 where he volunteered at the Edmund Rice School in Fr Eusebius’ home town of Arusha.
Oscar fell in love with Africa and realised that though the world is not what it should be, the change needs to come from within. Oscar is completing his Bachelor of Agricultural Science Degree and plans to put his skills to good use the next time he visits Africa.
Copyright © 2016 TCEO. All rights reserved.
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Sex Positivity To Your Door With The Big Oh! Box
Since the beginning of 2016, I’ve started to infuse more sex-driven content into this little feminist lifestyle blog of mine. Part of that includes highlighting some of the most exciting and sex positive brands out there. So, when Big Oh! Box ended up on my Twitter feed, I was ecstatic. I spoke to husband and wife duo, Michael and Rachel Gibbs, about their unique adult subscription box.
Please introduce yourself to my awesome readers
Michael: Hi! I’m Michael Gibbs, the CEO of Passionate Ideas Inc and the company that started The Big Oh! Box. I’m the numbers guy and Rachel is the creative one; it works out great.
Rachel: I’m Rachel Gibbs, the Chief Creative Officer of Passionate Ideas Inc. I’m “the talent”. I have a deep love for my Sexuality and Gender Studies courses.
I understand you’re a husband and wife duo, how did Big Oh! Box start?
M: We wanted to do something positive and fun with our lives. So, we kept that in the back of our minds while we continued with our lives. Then one day, I was looking up adult subscriptions after having positive experiences with Lootcrate and Hello Fresh, but everything we saw had lingerie or people were sent toys they didn’t care for. For instance, one vlogger was sent a glass dildo that they wouldn’t use, and we wouldn’t have used the lingerie in any box. What a waste of an opportunity to make someone feel good. I asked myself, what did we like? Kink; we like to experience new things in the bedroom, then, it hit us. Where was the subscription box for people who like to explore?
R: I am very passionate about helping people and I love to have my mind blown. Michael and I had a lot of conversations about what our joint goals were and we were always on the same page, especially when it came to helping others. I love listening to podcasts while I work and I was introduced to one, that was focused on sex positivity and education, by a co-worker. I immediately became addicted and would talk with Michael about the various points of views on sex related topics and would share with him all of the things I had learned. It soon became pretty apparent that this is what excited us. It was something that we both enjoyed learning and talking about. We wanted a way that we could share ideas of sex positivity and inclusiveness, and we wanted to be able to reach various people with these ideas. We noticed that subscription services featuring adult toys were geared towards heterosexual couples with an emphasis on spicing up their sex lives with a featured “date night”. We felt that these boxes didn’t promote sex positivity in that they appeared to be very exclusive to heteronormative standards and identities. This is where we decided that we could make a difference. Everyone deserves to enjoy themselves, explore their sexuality, and play, regardless of how they identify sexually or socially. Our goal is to be inclusive of all body types and sexualities with an emphasis on pleasure and exploration. Society already tries to put us in a box; our goal is to provide an experience in a box without putting a person’s sexual orientation in there as well.
Did you face any difficulties when starting Big Oh! Box?
Michael: We needed to make sure we stayed sex positive and as gender neutral as possible, so everyone could play. The hardest part was planning the toys since we are all anatomically different, but we eventually figured out that you now have so much more choice; backdoor play, a rabbit, vibe and stroker to name a few. We came up with a theme that gives the user a new experience every time with the first two quarters focusing on senses. We also give our users the option to change their toy preferences.
What are the differences between both boxes?
M: ‘With Oh! Friend’ is focused on couples and comes with a large number of items. The ‘Sol-Oh!’ box is essentially a quarterly masturbation box! You get a toy, lube, sex toy cleaner along with some additional goodies.
R: Our couples box is all about partner play, it’s an experience curated for two (or more) people and is driven by a theme which encourages sexual exploration. This box includes an assortment of experiences including but not limited to: wax play, BDSM, and bondage play, depending on that quarter’s particular theme. Our solo box is geared towards toys and items that can be used alone, but can still provide maximum satisfaction and pleasure.
How do you ensure your boxes are LGBT+ friendly?
M: Our boxes are designed for all types of couples with no focus on just one type. We try to go for gender-neutral toys, but it can sometimes be hard figuring out which toys suits all anatomies.
R: Absolutely, our boxes are for everyone! The only thing you need is an open mind and a wandering hand to enjoy these boxes. Instead of having to identify who you play with, our boxes cater to how you play (anal play, vibrators, etc.). You get to curate your pleasure, so that we can provide you with items that will make you say “Oh!”
Your Twitter bio reads “You deserve something more than a date night“. Do you think, in a dating app-obsessed world, that there is a pressure to maintain ‘date night’s?
M: Rachel is going to be able to describe this better than I, but I think there is certainly still pressure on couples to keep date nights in the mix. Although, this added pressure is going to counteract the relaxation part to date night. Why waste the night on going out anyways? Stay in, enjoy each other, and let us help find new ways to play 😉
R: There is definitely a social stigma regarding dating that if people don’t “date” in a manner that is typically defined by society, then their life is clearly boring and lacking; especially their sex life. It is plastered everywhere in the media and hits us from all angles. We have enough stressors in our life, pleasure should not be one of them. A goal with Big Oh! Box is to play when and how you feel works best for you.
What’s your perfect date night?
M: Sushi and sake; home by 9 and bound by 9:15.
R: This is an answer that has evolved since Michael and I have had children. Currently, my perfect date night is where I can fully relax and enjoy my time with both myself with my partner without interruption.
What would you say your brand’s core values are?
M: To be inclusive of all types of couples, individuals, and persons.
R: To be sex positive and inclusive of everyone. We believe that everyone is entitled the opportunity to explore their bodies and find what makes them say “Oh!”.
I love the idea of your ‘Sol-Oh!’ box, do you think masturbation is still a taboo? If so, why?
M: I think all masturbation is still taboo; some friends of ours won’t like our Facebook page because everyone will know they play with toys.
R: Yes; I have strong thoughts on the taboo nature of masturbation and sexuality in general. I think that the way media portrays women’s sexuality forces standards on women that they feel they need to live up to and if they don’t, they’re broken. Society has taught us that the way a man’s body works is the default way for how all bodies should work, and when they function outside of this ‘norm’, then something is wrong. I think that women who don’t automatically become aroused at the thought or sight of something sexually relevant automatically assume that something is wrong with them. Additionally, porn gives women unrealistic standards of how they should be responding to sexual stimulation, such as by squirting, achieving multiple orgasms and being able to cum within mere minutes of playing. I believe that there should be space for women to explore their bodies and what brings them pleasure without falling into the ideas of these social influences. Our boxes encourage sexual exploration and self satisfaction without putting these expectations or extra pressures on them.
What do you hope to achieve with Big Oh! Box?
M: We hope to give everyone a chance to experience new ways to play with their partners or to try new solo toys that they wouldn’t have before.
R: We hope to encourage sex positivity and sexual exploration as a norm, so that people can break free from the stigmas that revolve around sex. Our goal is to create a safe space and context for them to explore and experiment with what brings them pleasure.
Don’t forget to check back later this month for a review of The Big Oh! Box!
Portrait by Heather Turner.
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Sex · 13 Comments
« A Feminist Colouring Book You’d Want To Give Your Kids
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What an interesting subscription box, it’s good that they aim for it to be suitable for everyone not just hetrosexual couples x
laurahartleyy says
Great to see that this couple had a creative idea and saw it through! I can imagine finding a sex subscription box that appeals to everyone is incredibly difficult so it’s good to have as much variety as possible!
What a great box, and brilliant answers too. Sex is so taboo and masturbation even more so in the UK. Boxes like these will hopefully encourage more fun behind closed doors and lead to bigger conversations.
Finally an adult toy company that promotes positive sex. What is more refreshing is that its toys are catered to all leaving you with more options to choose how you would like to pleasure yourself.
Kaz & Ickle Pickle (@IcklePicklex) says
Not sure what to say as a single mum of four, sex is the last thing on my mind! I love the concept though and loved reading all about the people behind the business. Kaz x
Life as Mum says
Sounds like a really interesting box to receive. Great interview.
Angela Milnes says
I think its an interesting idea. It’s not something I’d personally be interested in but good for them coming up with an idea and following through. Angela
It’s nice to hear how inclusive they are in their product line. Theyr’e right. Everyone deserves to have the big oh!
Rebecca Smith says
This sounds like a really interesting subscription box! Looking forward to reading your review
Nayna Kanabar (@SIMPLYF00D) says
I have heard of many types of subscription boxes from, beauty, food, baking, crafts, and even one for pets but this one has got me gob smacked!!! 🙂
Emma White (@TheRealSupermum) says
See thats the main problem with toys these days they are not catered to please both mainly wither just for her or just for him so love this idea
WhatLauraLoves (@whatlauraloves) says
It is great that there really is a subscription box service available to everyone these days! xxx
Nicol says
I’ve never heard of an adult box before! This is a first. Its quite a good idea actually
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CEBP Focus Archive
Highly Cited Collection
Prevention and Early Detection
Null Results in Brief
Dietary Factors and Risk of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: A Pooled Analysis of Two Prospective Studies
Huei-Ting Tsai, Amanda J. Cross, Barry I. Graubard, Martin Oken, Arthur Schatzkin and Neil E. Caporaso
Huei-Ting Tsai
Amanda J. Cross
Barry I. Graubard
Martin Oken
Arthur Schatzkin
Neil E. Caporaso
DOI: 10.1158/1055-9965.EPI-10-0585 Published October 2010
Background: Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known.
Methods: Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up.
Results: We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36).
Conclusion: We did not find any associations between food or nutrient intake and CLL/SLL.
Impact: Our large prospective study indicates that diet may not play a role in CLL/SLL development. Cancer Epidemiol Biomarkers Prev; 19(10); 2680–4. ©2010 AACR.
Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are the most common leukemias in the western hemisphere. Because they share very similar demographic features and no decisive evidence supports differences in risk factors, many etiologic studies combine them. Advanced age, race (Caucasian > African American > Asian), and male gender are established risk factors for CLL/SLL, and familial and migration studies support a genetic component. However, no environmental risk factors have been reproducibly identified.
Several studies have suggested associations between some dietary factors and CLL/SLL, but the findings are inconsistent due to small sample size and retrospective study designs (1-6). Given that fruits and vegetables contain antioxidants, and diets high in fat and animal protein may alter immunocompetence, we hypothesize that diet may play a role in CLL/SLL. We conducted an analysis in a pooled dataset of two large prospective studies.
We pooled data from the NIH-AARP Diet and Health study and the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial; details of their design have previously been described (7, 8). Briefly, the NIH-AARP Diet and Health study is a cohort of 567,169 men and women ages 50 to 71 years from eight U.S. states. PLCO is a cancer screening trial of 155,000 men and women ages 55 to 74 years from 10 centers throughout the United States. We restricted our analyses to Caucasians without a personal history of cancer (except basal skin cancer) and excluded outliers for energy intake (top and bottom 1%) and body mass index (BMI) <18.5 or >50 kg/m2.
Exposure assessment and end-point ascertainment
Diet was assessed in both cohorts at baseline by a self-administered food frequency questionnaire-diet history questionnaire, which has been validated using 24-hour dietary recalls (9). The diet history questionnaire assessed the usual frequency of consumption and portion size of foods and beverages over the previous 12 months. Dietary variables were energy adjusted by the nutrient density method. Incident CLL/SLL cases were identified by linkage to state cancer registries in the NIH-AARP Diet and Heath study and through study screening centers and annual study questionnaires in the PLCO trial.
We used the Wilcoxon rank-sum test to investigate intake distributions between cases and controls. Dietary variables were categorized into quartiles and the median of each quartile was used to compute P-trend values. We used Cox proportional hazards regression, with age as the underlying time metric, to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Follow-up began from date of randomization or completion of questionnaire and ended at diagnosis of CLL/SLL, moving out of study areas, or through 2006 for the NIH-AARP Diet and Health study or 2007 for the PLCO trial. We conducted sensitivity analyses that only included cases diagnosed after the first year of follow-up.
We identified 1,129 incident CLL/SLL cases among 525,982 participants (median age, 63 years; 59% male) from the two cohorts during up to 11.2 years of follow-up (median, 10.5 years). Men had an increased risk of CLL/SLL (HR, 1.67; 95% CI, 1.46-1.90) compared with women (Table 1). In addition, there was a suggestive positive association between BMI and CLL/SLL [HR, 1.30 (95% CI, 0.99-1.69) for BMI >35 kg/m2 compared with BMI ≤25 kg/m2]. However, education, smoking, alcohol, or multivitamin use was not associated with CLL/SLL (Table 1).
Population characteristic and lifestyle factors in relation to risk of CLL and SLL among 525,982 men and women from the two cohort studies
Comparing those in the highest intake quartile to those in the lowest, we found no associations between total fat (HR, 0.87; 95% CI, 0.73-1.03), saturated fat (HR, 0.87; 95% CI, 0.73-1.03), fiber (HR, 1.03; 95% CI, 0.87-1.23), red meat (HR, 0.90; 95% CI, 0.76-1.08), processed meat (HR, 0.88; 95% CI, 0.74-1.05), vegetables (HR, 0.93; 95% CI, 0.78-1.11), or fruit (HR, 0.93; 95% CI, 0.78-1.12) intake and CLL/SLL (Table 2). Furthermore, we found no association between intake of foods with a high glycemic index or high glycemic load and CLL/SLL. Conducting a 1-year lag analysis did not alter our findings.
Diet in relation to CLL and SLL risk among 525,982 men and women from two cohort studies
In this pooled analysis of more than half a million people from two prospective studies, we found no associations between diet and CLL/SLL. The suggestive increased risk of CLL/SLL for those with a BMI >25 kg/m2 requires further investigation.
Limited sample size and recall bias are major issues when investigating diet and non–Hodgkin's lymphoma. Case-control studies have reported positive associations between intakes of fried red meat (4), processed meat (1), rice or pasta (2), and fat and saturated fat (1, 5) and risk of CLL/SLL; these findings were not replicated in our study.
Although no foods or nutrients were associated with risk for CLL/SLL, we identified a suggestive positive association between BMI and CLL/SLL. Obesity can lead to decreased immune response and changes in endogenous hormone metabolism, which may increase the risk of CLL/SLL. Studies with appropriate molecular markers that are relevant to immune and metabolic functions will be useful to further explore the association between BMI and CLL/SLL.
The strengths of our study include its large size and prospective dietary assessment. Nevertheless, our study was limited by having dietary data from a single time point and potential measurement error associated with self-reported assessment. In summary, we did not find any associations between food or nutrient intake and CLL/SLL.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
We thank the participating institutions in the NIH-AARP Diet and Health Study and PLCO trial for data collection and the Information Management Services for data quality control. We are deeply indebted to participants in the NIH-AARP Diet and Health Study and PLCO trial for their invaluable contribution.
Grant Support: This research was supported by the Intramural Research Program of the National Cancer Institute, NIH, Department of Health and Human Service.
Revision received July 15, 2010.
Accepted July 22, 2010.
Purdue MP,
Bassani DG,
Klar NS,
Sloan M,
Kreiger N
. Dietary factors and risk of non-Hodgkin lymphoma by histologic subtype: a case-control analysis. Cancer Epidemiol Biomarkers Prev 2004;13:1665–76.
Talamini R,
Polesel J,
Montella M,
. Food groups and risk of non-Hodgkin lymphoma: a multicenter, case-control study in Italy. Int J Cancer 2006;118:2871–6.
Kelemen LE,
Wang SS,
Lim U,
. Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma risk. Cancer Causes Control 2008;19:491–503.
Chang ET,
Smedby KE,
Zhang SM,
. Dietary factors and risk of non-Hodgkin lymphoma in men and women. Cancer Epidemiol Biomarkers Prev 2005;14:512–20.
Zheng T,
Holford TR,
Leaderer B,
. Diet and nutrient intakes and risk of non-Hodgkin's lymphoma in Connecticut women. Am J Epidemiol 2004;159:454–66.
Balter KM,
Torrang A,
. Nutrient intake and risk of non-Hodgkin's lymphoma. Am J Epidemiol 2006;164:1222–32.
Prorok PC,
Andriole GL,
Bresalier RS,
. Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials 2000;21:273S–309S.
Schatzkin A,
Subar AF,
Thompson FE,
. Design and serendipity in establishing a large cohort with wide dietary intake distributions: the National Institutes of Health-American Association of Retired Persons Diet and Health Study. Am J Epidemiol 2001;154:1119–25.
Kipnis V,
. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: the Eating at America's Table Study. Am J Epidemiol 2001;154:1089–99.
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Cancer Epidemiol Biomarkers Prev October 1 2010 (19) (10) 2680-2684; DOI: 10.1158/1055-9965.EPI-10-0585
Body Composition, Aspirin, and Colorectal Adenomas
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You Are Here: Home » Entertainment » Most Expensive Movie Write-offs:
Most Expensive Movie Write-offs:
You’ve all seen the movies and everyone’s gasped at the sights of the amazing cars that most people could only dream of and then sat in horror to watch as they crash these amazing cars in such spectacular style. Well, here’s a few of them and the cost of the insurance claims today.
Ferris Beuller’s Day Off:
1961 Ferrari 250 GT California Spider
Nowadays that claim would be worth around £7,000,000
The real version of the car was not destroyed it was a replica
There were only 100 of the real cars ever made
The car was however insured while on set for its true insurance value
At a 2008 auction a 1961 Ferrari 250 GT California Spider was sold for £7.5 million
Its value at the time of production was around £225,000
In this film the star Ferris Beuller takes a day off school pretending to be sick. On the same day his best friend Cameron really is sick but is persuaded to ‘borrow’ his dad’s Ferrari for the day and consequently it gets written off.
Fast and Furious:
1970 Dodge Charger plus around 200 further cars were written off
That claim would have been worth around £3.2 million
The film centres on police getting into the LA subculture that was street racing.
Christine:
1958 Plymouth Fury (24 to be precise)
Today the insurance claim would be £1,000,000
Although the insurance claim has been converted from the original insurance price today just one Plymouth Fury is worth £35,000
The film’s success put the car in great demand
Today they are a collector’s item
Christine was the name of the car. She disliked anyone that got inside her and therefore killed them. However, no matter what kind of damage she endured she always looked brand new.
Aston Martin DBS V12
Today’s claim value £600,000
The three Aston Martin DBS V12 that were totalled in this film were donated by Aston Martin
It is more likely than not that the cars were not insured as knowing what would happen to them it would have been impossible
The Italian Job (1969)
The vehicles destroyed in this film include a bus, 2 E-type Jaguars and 3 Mini Cooper Sports
The insurance claim today would have been around £170,000
The main character uses all of these vehicles to try and out do the Mafia in order to steal its gold.
Blues Brothers (1980)
1974 Dodge Monaco Sedan along with 70 police cars
Today’s claim would be £131,000
Written by Gina Wells for www.devinescs.com, leaders in private transfers.
Posted by: News Editor On: September 15, 2012 In: Entertainment | comments : 0
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GIRD YOUR LOINS!
4,360+ Flights Canceled Before Blizzard
Carlo Allegri/Reuters
The impending blizzard that could dump as much as three feet of snow on New York City has already started wreaking havoc on travel—and it’s barely flurries so far. Some 4,360 flights set for Monday and Tuesday have been preemptively canceled on the East Coast. It’s possible that all flights will be grounded for the three airports serving New York. Boston’s Logan International Airport has announced today’s last flight will leave at 7:30 p.m.
GALLERY: The 5 Worst Blizzards in American History
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