Unnamed: 0
int64
1
20.1k
Entry ID
stringlengths
4
8
Experimental Method
stringclasses
4 values
Deposition Date
stringdate
1990-04-02 00:00:00
2025-12-09 00:00:00
Release Date
stringdate
1991-07-15 00:00:00
2026-03-04 00:00:00
Ligand
stringclasses
339 values
Value
float64
0.01
183M
Type
stringclasses
5 values
Unit
stringclasses
2 values
PDB ID
stringlengths
4
8
Total Number of Non-polymer Instances
float64
1
168
Refinement Resolution (Å)
stringclasses
466 values
Structure Determination Methodology
stringclasses
1 value
DOI
stringlengths
12
34
Expression Host
stringclasses
33 values
Source Organism
stringclasses
52 values
Macromolecule Name
stringlengths
3
318
Entity ID
float64
1
16
Ligand ID
stringlengths
2
8
Ligand Name
stringlengths
5
339
Ligand SMILES
stringlengths
4
121
Protein
stringclasses
3 values
Molecular Weight
float64
150
978
3,100
8ZKO
ELECTRON MICROSCOPY
2024-05-17
2025-04-02
null
null
null
null
8ZKO
3
3.13
experimental
10.1038/s41467-025-58131-8
Homo sapiens
Homo sapiens
Monocarboxylate transporter 8
1
PC1
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
HSA
790.161
3,101
8ZKO
ELECTRON MICROSCOPY
2024-05-17
2025-04-02
null
null
null
null
8ZKO
3
3.13
experimental
10.1038/s41467-025-58131-8
Homo sapiens
Homo sapiens
Monocarboxylate transporter 8
1
T3
3,5,3'TRIIODOTHYRONINE
c1cc(c(cc1Oc2c(cc(cc2I)CC(C(=O)O)N)I)I)O
HSA
650.976
3,102
9DWY
ELECTRON MICROSCOPY
2024-10-10
2025-07-16
null
null
null
null
9DWY
1
2.9
experimental
10.1016/j.cell.2025.06.032
Homo sapiens
Homo sapiens
Monocarboxylate transporter 8
1
T3
3,5,3'TRIIODOTHYRONINE
c1cc(c(cc1Oc2c(cc(cc2I)CC(C(=O)O)N)I)I)O
HSA
650.976
3,103
9M8Y
ELECTRON MICROSCOPY
2025-03-13
2025-06-18
null
null
null
null
9M8Y
1
3.27
experimental
null
Homo sapiens
Homo sapiens
Isoform 2 of Solute carrier family 22 member 6
1
X56
Cefazolin
Cc1nnc(s1)SCC2=C(N3C(C(C3=O)NC(=O)Cn4cnnn4)SC2)C(=O)O
HSA
454.519
3,104
1DVS
X-RAY DIFFRACTION
2000-01-22
2001-01-22
null
null
null
null
1DVS
1
2
experimental
10.1038/74082
Escherichia coli
Homo sapiens
TRANSTHYRETIN
1
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247
3,105
1F86
X-RAY DIFFRACTION
2000-06-29
2001-06-29
null
null
null
null
1F86
2
1.1
experimental
10.1006/jmbi.2000.4415
Escherichia coli
Homo sapiens
TRANSTHYRETIN THR119MET VARIANT
1
T44
3,5,3',5'-TETRAIODO-L-THYRONINE
c1c(cc(c(c1I)Oc2cc(c(c(c2)I)O)I)I)CC(C(=O)O)N
HSA
776.872
3,110
3OZK
X-RAY DIFFRACTION
2010-09-25
2011-08-24
null
null
null
null
3OZK
2
1.9
experimental
null
Escherichia coli
Homo sapiens
Transthyretin
1
T44
3,5,3',5'-TETRAIODO-L-THYRONINE
c1c(cc(c(c1I)Oc2cc(c(c(c2)I)O)I)I)CC(C(=O)O)N
HSA
776.872
3,111
4BVV
X-RAY DIFFRACTION
2013-06-28
2014-07-16
null
null
null
null
4BVV
2
1.8
experimental
null
Komagataella pastoris
Homo sapiens
APOLIPOPROTEIN(A)
1
CPF
1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
c1c2c(cc(c1F)N3CCNCC3)N(C=C(C2=O)C(=O)O)C4CC4
HSA
331.347
3,113
5KM9
X-RAY DIFFRACTION
2016-06-26
2017-06-28
null
null
null
null
5KM9
4
1.45
experimental
10.1021/acs.molpharmaceut.7b00664
Escherichia coli
Homo sapiens
Histidine triad nucleotide-binding protein 2, mitochondrial
1
ADN
ADENOSINE
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CO)O)O)N
HSA
267.245
3,114
5KM9
X-RAY DIFFRACTION
2016-06-26
2017-06-28
null
null
null
null
5KM9
4
1.45
experimental
10.1021/acs.molpharmaceut.7b00664
Escherichia coli
Homo sapiens
Histidine triad nucleotide-binding protein 2, mitochondrial
1
PG4
TETRAETHYLENE GLYCOL
C(COCCOCCOCCO)O
HSA
194.227
3,118
6PAH
X-RAY DIFFRACTION
1998-08-20
1999-04-27
null
null
null
null
6PAH
2
2.15
experimental
10.1021/bi9815290
Escherichia coli
Homo sapiens
PHENYLALANINE 4-MONOOXYGENASE
1
DAH
3,4-DIHYDROXYPHENYLALANINE
c1cc(c(cc1CC(C(=O)O)N)O)O
HSA
197.19
3,119
6XU9
X-RAY DIFFRACTION
2020-01-17
2020-04-08
null
null
null
null
6XU9
3
2.7
experimental
10.1074/jbc.RA120.013087
Escherichia coli
Homo sapiens
Myelin P2 protein
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,121
6XU9
X-RAY DIFFRACTION
2020-01-17
2020-04-08
null
null
null
null
6XU9
3
2.7
experimental
10.1074/jbc.RA120.013087
Escherichia coli
Homo sapiens
Myelin P2 protein
1
CIT
CITRIC ACID
C(C(=O)O)C(CC(=O)O)(C(=O)O)O
HSA
192.123
3,122
6XVQ
X-RAY DIFFRACTION
2020-01-22
2020-04-08
null
null
null
null
6XVQ
2
1.8
experimental
10.1074/jbc.RA120.013087
Escherichia coli
Homo sapiens
Myelin P2 protein
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,123
6XVQ
X-RAY DIFFRACTION
2020-01-22
2020-04-08
null
null
null
null
6XVQ
2
1.8
experimental
10.1074/jbc.RA120.013087
Escherichia coli
Homo sapiens
Myelin P2 protein
1
CIT
CITRIC ACID
C(C(=O)O)C(CC(=O)O)(C(=O)O)O
HSA
192.123
3,124
7A9Y
X-RAY DIFFRACTION
2020-09-02
2021-02-17
null
null
null
null
7A9Y
3
1.64
experimental
10.1107/S2059798320015247
Escherichia coli BL21
Homo sapiens
Cellular retinoic acid-binding protein 1
1
MYR
MYRISTIC ACID
CCCCCCCCCCCCCC(=O)O
HSA
228.376
3,126
7A9Y
X-RAY DIFFRACTION
2020-09-02
2021-02-17
null
null
null
null
7A9Y
3
1.64
experimental
10.1107/S2059798320015247
Escherichia coli BL21
Homo sapiens
Cellular retinoic acid-binding protein 1
1
TDA
N-TRIDECANOIC ACID
CCCCCCCCCCCCC(=O)O
HSA
214.349
3,127
7D7V
X-RAY DIFFRACTION
2020-10-06
2020-11-25
null
null
null
null
7D7V
10
2.8
experimental
10.1093/nar/gkaa1029
bacterium
Homo sapiens
U1 small nuclear ribonucleoprotein A
2
GTP
GUANOSINE-5'-TRIPHOSPHATE
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
HSA
523.181
3,130
7DZI
X-RAY DIFFRACTION
2021-01-25
2022-07-27
null
null
null
null
7DZI
2
1.65
experimental
10.1038/s41557-022-00992-3
Escherichia coli
Homo sapiens
Fatty acid-binding protein, liver
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,131
7DZK
X-RAY DIFFRACTION
2021-01-25
2022-07-27
null
null
null
null
7DZK
2
1.54
experimental
10.1038/s41557-022-00992-3
Escherichia coli
Homo sapiens
Fatty acid-binding protein, liver
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,132
7F3G
X-RAY DIFFRACTION
2021-06-16
2021-08-18
RXT
68
Kd
nM
7F3G
2
2.1
experimental
10.3390/ijms22168488
Escherichia coli
Homo sapiens
Isoform 4 of Serine/threonine-protein kinase DCLK1
1
RXT
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
c1c[nH]c2c1c(ncn2)c3cnn(c3)C(CC#N)C4CCCC4
HSA
306.373
3,133
8S61
ELECTRON MICROSCOPY
2024-02-26
2024-10-02
null
null
null
null
8S61
1
3.53
experimental
10.1038/s41467-024-52872-8
Homo sapiens
Homo sapiens
Thiamine transporter 2
2
VIB
3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM
Cc1c(sc[n+]1Cc2cnc(nc2N)C)CCO
HSA
265.362
3,135
8XV2
ELECTRON MICROSCOPY
2024-01-14
2024-03-27
null
null
null
null
8XV2
1
3.7
experimental
10.1038/s41422-024-00951-2
Homo sapiens
Escherichia coli, Homo sapiens
Soluble cytochrome b562,Thiamine transporter 2
1
VIB
3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM
Cc1c(sc[n+]1Cc2cnc(nc2N)C)CCO
HSA
265.362
3,136
9GSZ
ELECTRON MICROSCOPY
2024-09-16
2025-05-21
null
null
null
null
9GSZ
1
3.8
experimental
10.1038/s41467-025-59751-w
Homo sapiens
Homo sapiens
Monocarboxylate transporter 10
1
T44
3,5,3',5'-TETRAIODO-L-THYRONINE
c1c(cc(c(c1I)Oc2cc(c(c(c2)I)O)I)I)CC(C(=O)O)N
HSA
776.872
3,138
3A7E
X-RAY DIFFRACTION
2009-09-26
2010-09-15
null
null
null
null
3A7E
3
2.8
experimental
null
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
SAM
S-ADENOSYLMETHIONINE
C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
HSA
398.445
3,139
3A7E
X-RAY DIFFRACTION
2009-09-26
2010-09-15
null
null
null
null
3A7E
3
2.8
experimental
null
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
DNC
3,5-DINITROCATECHOL
c1c(cc(c(c1[N+](=O)[O-])O)O)[N+](=O)[O-]
HSA
200.106
3,140
3CTR
X-RAY DIFFRACTION
2008-04-14
2008-07-29
null
null
null
null
3CTR
1
2.1
experimental
10.1016/j.jmb.2008.07.073
Escherichia coli
Homo sapiens
Poly(A)-specific ribonuclease PARN
1
MGP
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
C[n+]1cn(c2c1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
HSA
538.216
3,141
4JQ1
X-RAY DIFFRACTION
2013-03-19
2014-04-02
NPS
1,100
IC50
nM
4JQ1
8
1.6
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
Aldo-keto reductase family 1 member C2
1
NPS
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
CC(c1ccc2cc(ccc2c1)OC)C(=O)O
HSA
230.263
3,148
6I3C
X-RAY DIFFRACTION
2018-11-05
2019-09-18
null
null
null
null
6I3C
3
1.336
experimental
10.1021/acscatal.9b00174
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
SAM
S-ADENOSYLMETHIONINE
C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
HSA
398.445
3,149
6I3C
X-RAY DIFFRACTION
2018-11-05
2019-09-18
null
null
null
null
6I3C
3
1.336
experimental
10.1021/acscatal.9b00174
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
DNC
3,5-DINITROCATECHOL
c1c(cc(c(c1[N+](=O)[O-])O)O)[N+](=O)[O-]
HSA
200.106
3,152
4XUE
X-RAY DIFFRACTION
2015-01-25
2015-04-15
43J
170
IC50
nM
4XUE
6
2.3
experimental
10.1021/ml500502d
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
43J
2-(biphenyl-3-yl)-5-hydroxy-3-methylpyrimidin-4(3H)-one
CN1C(=NC=C(C1=O)O)c2cccc(c2)c3ccccc3
HSA
278.311
3,155
6I3D
X-RAY DIFFRACTION
2018-11-05
2019-09-18
null
null
null
null
6I3D
6
1.45
experimental
10.1021/acscatal.9b00174
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
DNC
3,5-DINITROCATECHOL
c1c(cc(c(c1[N+](=O)[O-])O)O)[N+](=O)[O-]
HSA
200.106
3,157
6I3D
X-RAY DIFFRACTION
2018-11-05
2019-09-18
null
null
null
null
6I3D
6
1.45
experimental
10.1021/acscatal.9b00174
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
SFG
SINEFUNGIN
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O)N
HSA
381.393
3,159
8XOM
ELECTRON MICROSCOPY
2024-01-01
2024-07-17
MTX
133,000
IC50
nM
8XOM
18
3.05
experimental
10.1002/1873-3468.14955
Mammalian expression vector Flag-MCS-pcDNA3.1
Homo sapiens
ATP-binding cassette sub-family C member 4
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,160
8XOM
ELECTRON MICROSCOPY
2024-01-01
2024-07-17
MTX
133,000
IC50
nM
8XOM
18
3.05
experimental
10.1002/1873-3468.14955
Mammalian expression vector Flag-MCS-pcDNA3.1
Homo sapiens
ATP-binding cassette sub-family C member 4
1
DU0
2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol
CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OCCC(CO)CO)C)C)C)OC1
HSA
516.763
3,161
8XOM
ELECTRON MICROSCOPY
2024-01-01
2024-07-17
MTX
133,000
IC50
nM
8XOM
18
3.05
experimental
10.1002/1873-3468.14955
Mammalian expression vector Flag-MCS-pcDNA3.1
Homo sapiens
ATP-binding cassette sub-family C member 4
1
MTX
METHOTREXATE
CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O
HSA
454.447
3,162
8XOM
ELECTRON MICROSCOPY
2024-01-01
2024-07-17
MTX
133,000
IC50
nM
8XOM
18
3.05
experimental
10.1002/1873-3468.14955
Mammalian expression vector Flag-MCS-pcDNA3.1
Homo sapiens
ATP-binding cassette sub-family C member 4
1
ANP
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N
HSA
506.198
3,167
3BWM
X-RAY DIFFRACTION
2008-01-09
2008-06-03
null
null
null
null
3BWM
4
1.98
experimental
10.1016/j.jmb.2008.04.040
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
SAM
S-ADENOSYLMETHIONINE
C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
HSA
398.445
3,168
3BWM
X-RAY DIFFRACTION
2008-01-09
2008-06-03
null
null
null
null
3BWM
4
1.98
experimental
10.1016/j.jmb.2008.04.040
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
DNC
3,5-DINITROCATECHOL
c1c(cc(c(c1[N+](=O)[O-])O)O)[N+](=O)[O-]
HSA
200.106
3,170
3BWY
X-RAY DIFFRACTION
2008-01-10
2008-06-03
null
null
null
null
3BWY
6
1.3
experimental
10.1016/j.jmb.2008.04.040
Escherichia coli
Homo sapiens
COMT protein
1
SAM
S-ADENOSYLMETHIONINE
C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
HSA
398.445
3,171
3BWY
X-RAY DIFFRACTION
2008-01-10
2008-06-03
null
null
null
null
3BWY
6
1.3
experimental
10.1016/j.jmb.2008.04.040
Escherichia coli
Homo sapiens
COMT protein
1
DNC
3,5-DINITROCATECHOL
c1c(cc(c(c1[N+](=O)[O-])O)O)[N+](=O)[O-]
HSA
200.106
3,175
5LSA
X-RAY DIFFRACTION
2016-08-24
2016-09-07
null
null
null
null
5LSA
4
1.5
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
Catechol O-methyltransferase
1
SAM
S-ADENOSYLMETHIONINE
C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
HSA
398.445
3,176
5LSA
X-RAY DIFFRACTION
2016-08-24
2016-09-07
null
null
null
null
5LSA
4
1.5
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
Catechol O-methyltransferase
1
DNC
3,5-DINITROCATECHOL
c1c(cc(c(c1[N+](=O)[O-])O)O)[N+](=O)[O-]
HSA
200.106
3,183
207L
X-RAY DIFFRACTION
1996-03-26
1996-10-14
null
null
null
null
207L
1
1.8
experimental
null
Escherichia coli
Homo sapiens
LYSOZYME
1
SC2
N-ACETYL-L-CYSTEINE
CC(=O)NC(CS)C(=O)O
HSA
163.198
3,184
2OVD
X-RAY DIFFRACTION
2007-02-13
2007-05-22
null
null
null
null
2OVD
1
1.8
experimental
10.1016/j.bbapap.2007.03.004
Escherichia coli
Homo sapiens
Complement component 8, gamma polypeptide
1
DAO
LAURIC ACID
CCCCCCCCCCCC(=O)O
HSA
200.322
3,185
3CKL
X-RAY DIFFRACTION
2008-03-16
2008-04-01
null
null
null
null
3CKL
4
2
experimental
null
Escherichia coli
Homo sapiens
Sulfotransferase family cytosolic 1B member 1
1
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247
3,186
3CKL
X-RAY DIFFRACTION
2008-03-16
2008-04-01
null
null
null
null
3CKL
4
2
experimental
null
Escherichia coli
Homo sapiens
Sulfotransferase family cytosolic 1B member 1
1
A3P
ADENOSINE-3'-5'-DIPHOSPHATE
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)O)OP(=O)(O)O)O)N
HSA
427.203
3,191
4IK7
X-RAY DIFFRACTION
2012-12-25
2013-01-30
null
null
null
null
4IK7
2
2.1
experimental
null
Escherichia coli
Homo sapiens
Transthyretin
1
IMN
INDOMETHACIN
Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)O
HSA
357.793
3,192
9J06
ELECTRON MICROSCOPY
2024-08-02
2025-08-13
null
null
null
null
9J06
1
3.68
experimental
10.1126/sciadv.ads5405
Homo sapiens
Homo sapiens
Solute carrier family 22 member 6
1
GBM
5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
COc1ccc(cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3)Cl
HSA
494.013
3,193
1DVX
X-RAY DIFFRACTION
2000-01-23
2001-01-23
null
null
null
null
1DVX
1
2
experimental
10.1038/74082
Escherichia coli
Homo sapiens
TRANSTHYRETIN
1
DIF
2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID
c1ccc(c(c1)CC(=O)O)Nc2c(cccc2Cl)Cl
HSA
296.153
3,195
2ZB8
X-RAY DIFFRACTION
2007-10-16
2008-09-30
null
null
null
null
2ZB8
4
2
experimental
10.1016/j.str.2008.09.007
Escherichia coli
Homo sapiens
Prostaglandin reductase 2
1
NAP
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)OP(=O)(O)O)O)O)O)C(=O)N
HSA
743.409
3,196
2ZB8
X-RAY DIFFRACTION
2007-10-16
2008-09-30
null
null
null
null
2ZB8
4
2
experimental
10.1016/j.str.2008.09.007
Escherichia coli
Homo sapiens
Prostaglandin reductase 2
1
IMN
INDOMETHACIN
Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)O
HSA
357.793
3,197
3CFQ
X-RAY DIFFRACTION
2008-03-04
2009-03-03
null
null
null
null
3CFQ
2
2.09
experimental
10.1016/j.bmc.2009.11.025
Escherichia coli
Homo sapiens
Transthyretin
1
DIF
2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID
c1ccc(c(c1)CC(=O)O)Nc2c(cccc2Cl)Cl
HSA
296.153
3,199
5UC9
X-RAY DIFFRACTION
2016-12-22
2017-02-15
null
null
null
null
5UC9
4
1.903
experimental
10.1016/j.chom.2017.01.002
Escherichia coli
Homo sapiens
Heme oxygenase 2
1
MYR
MYRISTIC ACID
CCCCCCCCCCCCCC(=O)O
HSA
228.376
3,200
6L6E
X-RAY DIFFRACTION
2019-10-28
2020-09-02
E6L
5,200
IC50
nM
6L6E
4
1.92
experimental
10.1021/acs.jmedchem.0c00853
Escherichia coli BL21(DE3)
Homo sapiens
cGMP-specific 3',5'-cyclic phosphodiesterase
1
E6L
4-[(3-chloranyl-4-methoxy-phenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimid ine-5-carboxamide
COc1ccc(cc1Cl)CNc2c(cnc(n2)N3CCCC3CO)C(=O)NCc4ncccn4
HSA
483.96
3,204
9D6X
X-RAY DIFFRACTION
2024-08-16
2025-08-20
null
null
null
null
9D6X
7
1.95
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
Prostaglandin reductase 1
1
MTX
METHOTREXATE
CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O
HSA
454.447
3,206
9KL5
ELECTRON MICROSCOPY
2024-11-14
2025-11-05
null
null
null
null
9KL5
2
3.33
experimental
10.1016/j.str.2025.07.019
Homo sapiens
Homo sapiens
Solute carrier family 22 member 6
1
RTO
4-(dipropylsulfamoyl)benzoic acid
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O
HSA
285.365
3,208
9U55
ELECTRON MICROSCOPY
2025-03-20
2025-06-18
null
null
null
null
9U55
1
3.17
experimental
null
Homo sapiens
Homo sapiens
Isoform 2 of Solute carrier family 22 member 6
1
RTO
4-(dipropylsulfamoyl)benzoic acid
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O
HSA
285.365
3,209
1SZ7
X-RAY DIFFRACTION
2004-04-05
2005-01-18
null
null
null
null
1SZ7
1
1.55
experimental
10.1038/sj.emboj.7600565
Saccharomyces cerevisiae
Homo sapiens
Trafficking protein particle complex subunit 3
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,210
2WH5
X-RAY DIFFRACTION
2009-04-30
2009-07-28
null
null
null
null
2WH5
14
2.6
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4
1
COA
COENZYME A
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCS)O
HSA
767.541
3,212
2WH5
X-RAY DIFFRACTION
2009-04-30
2009-07-28
null
null
null
null
2WH5
14
2.6
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4
1
STE
STEARIC ACID
CCCCCCCCCCCCCCCCCC(=O)O
HSA
284.484
3,213
2XN5
X-RAY DIFFRACTION
2010-07-30
2011-02-16
null
null
null
null
2XN5
9
1.7
experimental
10.1074/JBC.M110.171082
Escherichia coli BL21(DE3)
Homo sapiens
THYROXINE-BINDING GLOBULIN
2
FUN
5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID
c1cc(oc1)CNc2cc(c(cc2C(=O)O)S(=O)(=O)N)Cl
HSA
330.749
3,216
3FLV
X-RAY DIFFRACTION
2008-12-19
2009-02-03
null
null
null
null
3FLV
7
1.7
experimental
null
Escherichia coli
Homo sapiens
Acyl-CoA-binding domain-containing protein 5
1
STE
STEARIC ACID
CCCCCCCCCCCCCCCCCC(=O)O
HSA
284.484
3,217
3FLV
X-RAY DIFFRACTION
2008-12-19
2009-02-03
null
null
null
null
3FLV
7
1.7
experimental
null
Escherichia coli
Homo sapiens
Acyl-CoA-binding domain-containing protein 5
1
COA
COENZYME A
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCS)O
HSA
767.541
3,222
4IKI
X-RAY DIFFRACTION
2012-12-26
2013-01-30
null
null
null
null
4IKI
2
2
experimental
null
Escherichia coli
Homo sapiens
Transthyretin
1
IMN
INDOMETHACIN
Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)O
HSA
357.793
3,223
4QZT
X-RAY DIFFRACTION
2014-07-28
2014-12-10
null
null
null
null
4QZT
5
1.9
experimental
10.1107/S1399004714023839
Escherichia coli
Homo sapiens
Retinol-binding protein 2
1
RTL
RETINOL
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCO)C)C
HSA
286.459
3,233
6VVQ
X-RAY DIFFRACTION
2020-02-18
2020-09-02
null
null
null
null
6VVQ
1
3.09
experimental
10.1073/pnas.2003877117
Escherichia coli BL21(DE3)
Homo sapiens
Acyl-coenzyme A thioesterase 11
1
MYR
MYRISTIC ACID
CCCCCCCCCCCCCC(=O)O
HSA
228.376
3,234
7Q9O
X-RAY DIFFRACTION
2021-11-12
2022-11-23
null
null
null
null
7Q9O
4
1.35
experimental
10.1021/acschemneuro.2c00700
Escherichia coli
Homo sapiens
Transthyretin
1
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247
3,237
9BWT
ELECTRON MICROSCOPY
2024-05-21
2024-09-04
null
null
null
null
9BWT
3
2.5
experimental
10.1038/s41467-024-51381-y
Homo sapiens
Homo sapiens
Solute carrier family 12 member 3
1
HCZ
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
HSA
297.745
3,238
9BWT
ELECTRON MICROSCOPY
2024-05-21
2024-09-04
null
null
null
null
9BWT
3
2.5
experimental
10.1038/s41467-024-51381-y
Homo sapiens
Homo sapiens
Solute carrier family 12 member 3
1
ATP
ADENOSINE-5'-TRIPHOSPHATE
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
HSA
507.182
3,239
9D71
X-RAY DIFFRACTION
2024-08-16
2025-08-20
null
null
null
null
9D71
3
2
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
Prostaglandin reductase 1
1
MTX
METHOTREXATE
CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O
HSA
454.447
3,241
9ITG
ELECTRON MICROSCOPY
2024-07-20
2025-04-02
null
null
null
null
9ITG
16
3.03
experimental
10.1038/s41467-025-58200-y
Homo sapiens
Homo sapiens
Solute carrier family 53 member 1
1
IHP
INOSITOL HEXAKISPHOSPHATE
C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O
HSA
660.03
3,242
9ITG
ELECTRON MICROSCOPY
2024-07-20
2025-04-02
null
null
null
null
9ITG
16
3.03
experimental
10.1038/s41467-025-58200-y
Homo sapiens
Homo sapiens
Solute carrier family 53 member 1
1
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
3,243
9ITG
ELECTRON MICROSCOPY
2024-07-20
2025-04-02
null
null
null
null
9ITG
16
3.03
experimental
10.1038/s41467-025-58200-y
Homo sapiens
Homo sapiens
Solute carrier family 53 member 1
1
3PE
1,2-Distearoyl-sn-glycerophosphoethanolamine
CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCCCCCCCCCCC
HSA
748.08
3,244
9ITG
ELECTRON MICROSCOPY
2024-07-20
2025-04-02
null
null
null
null
9ITG
16
3.03
experimental
10.1038/s41467-025-58200-y
Homo sapiens
Homo sapiens
Solute carrier family 53 member 1
1
Y01
CHOLESTEROL HEMISUCCINATE
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C
HSA
486.737
3,245
9ITG
ELECTRON MICROSCOPY
2024-07-20
2025-04-02
null
null
null
null
9ITG
16
3.03
experimental
10.1038/s41467-025-58200-y
Homo sapiens
Homo sapiens
Solute carrier family 53 member 1
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,246
9ITG
ELECTRON MICROSCOPY
2024-07-20
2025-04-02
null
null
null
null
9ITG
16
3.03
experimental
10.1038/s41467-025-58200-y
Homo sapiens
Homo sapiens
Solute carrier family 53 member 1
1
1T9
(2S,3R,4E)-3-hydroxy-2-(octanoylamino)octadec-4-en-1-yl dihydrogen phosphate
CCCCCCCCCCCCCC=CC(C(COP(=O)(O)O)NC(=O)CCCCCCC)O
HSA
505.677
3,247
1QQS
X-RAY DIFFRACTION
1999-06-07
2000-04-21
null
null
null
null
1QQS
1
2.4
experimental
10.1021/bi992215v
unidentified baculovirus
Homo sapiens
NEUTROPHIL GELATINASE
1
DKA
DECANOIC ACID
CCCCCCCCCC(=O)O
HSA
172.268
3,248
4XUD
X-RAY DIFFRACTION
2015-01-25
2015-04-15
43H
200
IC50
nM
4XUD
4
2.4
experimental
10.1021/ml500502d
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
43H
[1-(biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid
B(C1=CN(C=C(C1=O)O)c2cccc(c2)c3ccccc3)(O)O
HSA
307.114
3,250
4XUD
X-RAY DIFFRACTION
2015-01-25
2015-04-15
43H
200
IC50
nM
4XUD
4
2.4
experimental
10.1021/ml500502d
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
SAM
S-ADENOSYLMETHIONINE
C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
HSA
398.445
3,251
4XUD
X-RAY DIFFRACTION
2015-01-25
2015-04-15
43H
200
IC50
nM
4XUD
4
2.4
experimental
10.1021/ml500502d
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
MES
2-(N-MORPHOLINO)-ETHANESULFONIC ACID
C1COCC[NH+]1CCS(=O)(=O)[O-]
HSA
195.24
3,252
4XUC
X-RAY DIFFRACTION
2015-01-25
2015-04-15
43G
1,100
IC50
nM
4XUC
4
1.8
experimental
10.1021/ml500502d
Escherichia coli
Homo sapiens
Catechol O-methyltransferase
1
43G
1-(biphenyl-3-yl)-3-hydroxypyridin-4(1H)-one
c1ccc(cc1)c2cccc(c2)N3C=CC(=O)C(=C3)O
HSA
263.296
3,259
2E9M
X-RAY DIFFRACTION
2007-01-25
2007-09-11
null
null
null
null
2E9M
3
1.8
experimental
10.1074/jbc.M700832200
Escherichia coli
Homo sapiens
Cytosolic beta-glucosidase
1
GAL
beta-D-galactopyranose
C(C1C(C(C(C(O1)O)O)O)O)O
HSA
180.156
3,260
2E9M
X-RAY DIFFRACTION
2007-01-25
2007-09-11
null
null
null
null
2E9M
3
1.8
experimental
10.1074/jbc.M700832200
Escherichia coli
Homo sapiens
Cytosolic beta-glucosidase
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,261
2E9M
X-RAY DIFFRACTION
2007-01-25
2007-09-11
null
null
null
null
2E9M
3
1.8
experimental
10.1074/jbc.M700832200
Escherichia coli
Homo sapiens
Cytosolic beta-glucosidase
1
OLA
OLEIC ACID
CCCCCCCCC=CCCCCCCCC(=O)O
HSA
282.468
3,266
2XN7
X-RAY DIFFRACTION
2010-07-30
2011-02-16
null
null
null
null
2XN7
5
1.43
experimental
10.1074/JBC.M110.171082
Escherichia coli BL21(DE3)
Homo sapiens
THYROXINE-BINDING GLOBULIN
1
T44
3,5,3',5'-TETRAIODO-L-THYRONINE
c1c(cc(c(c1I)Oc2cc(c(c(c2)I)O)I)I)CC(C(=O)O)N
HSA
776.872
3,270
3HKK
X-RAY DIFFRACTION
2009-05-24
2010-05-26
null
null
null
null
3HKK
8
2.9
experimental
null
Komagataella pastoris
Homo sapiens
Leukotriene C4 synthase
1
PAM
PALMITOLEIC ACID
CCCCCCC=CCCCCCCCC(=O)O
HSA
254.414
3,271
3HKK
X-RAY DIFFRACTION
2009-05-24
2010-05-26
null
null
null
null
3HKK
8
2.9
experimental
null
Komagataella pastoris
Homo sapiens
Leukotriene C4 synthase
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,272
3HKK
X-RAY DIFFRACTION
2009-05-24
2010-05-26
null
null
null
null
3HKK
8
2.9
experimental
null
Komagataella pastoris
Homo sapiens
Leukotriene C4 synthase
1
GTS
GLUTATHIONE SULFONIC ACID
C(CC(=O)NC(CS(=O)(=O)O)C(=O)NCC(=O)O)C(C(=O)O)N
HSA
355.325
3,273
3NR3
X-RAY DIFFRACTION
2010-06-30
2010-08-04
null
null
null
null
3NR3
8
1.95
experimental
null
Escherichia coli
Homo sapiens
PMP2 protein
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
3,276
3NR3
X-RAY DIFFRACTION
2010-06-30
2010-08-04
null
null
null
null
3NR3
8
1.95
experimental
null
Escherichia coli
Homo sapiens
PMP2 protein
1
CIT
CITRIC ACID
C(C(=O)O)C(CC(=O)O)(C(=O)O)O
HSA
192.123
3,277
3NR3
X-RAY DIFFRACTION
2010-06-30
2010-08-04
null
null
null
null
3NR3
8
1.95
experimental
null
Escherichia coli
Homo sapiens
PMP2 protein
1
EPE
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
C1CN(CCN1CCO)CCS(=O)(=O)O
HSA
238.309
3,280
4WNJ
X-RAY DIFFRACTION
2014-10-13
2015-08-05
null
null
null
null
4WNJ
3
1.398
experimental
10.1107/S1399004715010585
Escherichia coli 'BL21-Gold(DE3)pLysS AG
Homo sapiens
Transthyretin
1
QUE
3,5,7,3',4'-PENTAHYDROXYFLAVONE
c1cc(c(cc1C2=C(C(=O)c3c(cc(cc3O2)O)O)O)O)O
HSA
302.238
3,285
2WEW
X-RAY DIFFRACTION
2009-04-02
2009-09-15
null
null
null
null
2WEW
2
1.95
experimental
10.1016/J.JMB.2009.08.071
Escherichia coli BL21(DE3)
Homo sapiens
APOLIPOPROTEIN M
1
MYR
MYRISTIC ACID
CCCCCCCCCCCCCC(=O)O
HSA
228.376
3,287
8HNH
ELECTRON MICROSCOPY
2022-12-07
2023-09-13
null
null
null
null
8HNH
2
3.73
experimental
10.1038/s41422-023-00870-8
Homo sapiens
Homo sapiens
Solute carrier organic anion transporter family member 1B1
1
30B
(2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide
Cc1c(ccc2c1nc(cc2OC3CC4C(C3)C(=O)N(CCCCC=CC5CC5(NC4=O)C(=O)NS(=O)(=O)C6CC6)C)c7nc(cs7)C(C)C)OC
HSA
749.956
3,288
8HNH
ELECTRON MICROSCOPY
2022-12-07
2023-09-13
null
null
null
null
8HNH
2
3.73
experimental
10.1038/s41422-023-00870-8
Homo sapiens
Homo sapiens
Solute carrier organic anion transporter family member 1B1
1
NAG
2-acetamido-2-deoxy-beta-D-glucopyranose
CC(=O)NC1C(C(C(OC1O)CO)O)O
HSA
221.209
3,290
9D6Z
X-RAY DIFFRACTION
2024-08-16
2025-08-20
null
null
null
null
9D6Z
19
1.75
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
Prostaglandin reductase 1
1
MTX
METHOTREXATE
CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O
HSA
454.447
3,293
1JTV
X-RAY DIFFRACTION
2001-08-22
2003-06-24
null
null
null
null
1JTV
2
1.54
experimental
null
null
Homo sapiens
17 beta-hydroxysteroid dehydrogenase type 1
1
TES
TESTOSTERONE
CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
HSA
288.431
3,296
2GEH
X-RAY DIFFRACTION
2006-03-20
2006-06-20
null
null
null
null
2GEH
4
2
experimental
10.1016/j.bmcl.2006.05.068
null
Homo sapiens
Carbonic anhydrase 2
1
HG
MERCURY (II) ION
[Hg+2]
HSA
200.59
3,302
4Q93
X-RAY DIFFRACTION
2014-04-28
2014-12-17
null
null
null
null
4Q93
12
2.1
experimental
10.1038/nature14028
Escherichia coli
Homo sapiens
Tyrosine--tRNA ligase, cytoplasmic
1
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247