Unnamed: 0
int64
1
20.1k
Entry ID
stringlengths
4
8
Experimental Method
stringclasses
4 values
Deposition Date
stringdate
1990-04-02 00:00:00
2025-12-09 00:00:00
Release Date
stringdate
1991-07-15 00:00:00
2026-03-04 00:00:00
Ligand
stringclasses
339 values
Value
float64
0.01
183M
Type
stringclasses
5 values
Unit
stringclasses
2 values
PDB ID
stringlengths
4
8
Total Number of Non-polymer Instances
float64
1
168
Refinement Resolution (Å)
stringclasses
466 values
Structure Determination Methodology
stringclasses
1 value
DOI
stringlengths
12
34
Expression Host
stringclasses
33 values
Source Organism
stringclasses
52 values
Macromolecule Name
stringlengths
3
318
Entity ID
float64
1
16
Ligand ID
stringlengths
2
8
Ligand Name
stringlengths
5
339
Ligand SMILES
stringlengths
4
121
Protein
stringclasses
3 values
Molecular Weight
float64
150
978
12,516
7EW4
ELECTRON MICROSCOPY
2021-05-24
2021-09-29
JF9
105
EC50
nM
7EW4
3
3.2
experimental
10.1038/s41422-021-00567-w
Spodoptera frugiperda
Homo sapiens
scFV16
5
JF9
N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
c1c(onc1C(=O)N(C2CCCCC2)C3CCCCC3)C4CC4
HSA
316.445
12,521
7F16
ELECTRON MICROSCOPY
2021-06-08
2021-08-18
null
null
null
null
7F16
10
2.8
experimental
10.1073/pnas.2101279118
Trichoplusia ni
Lama glama
Nanobody-35
6
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
12,532
8BY6
ELECTRON MICROSCOPY
2022-12-12
2024-01-24
null
null
null
null
8BY6
1
3.19
experimental
10.1016/j.celrep.2023.113639
Escherichia coli
Homo sapiens
Nuclear cap-binding protein subunit 3
3
GTG
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE
C[n+]1cn(c2c1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)n5cnc6c5N=C(NC6=O)N)O)O)O)O
HSA
803.445
12,535
8FYX
ELECTRON MICROSCOPY
2023-01-26
2024-05-15
YLX
12
Ki
nM
8FYX
4
2.62
experimental
10.1038/s41586-024-07403-2
Spodoptera frugiperda
Homo sapiens
Soluble cytochrome b562,5-hydroxytryptamine receptor 1A,5-hydroxytryptamine receptor 1A
4
YLX
Buspirone
c1cnc(nc1)N2CCN(CC2)CCCCN3C(=O)CC4(CCCC4)CC3=O
HSA
385.512
12,601
8G1U
ELECTRON MICROSCOPY
2023-02-03
2023-08-23
null
null
null
null
8G1U
4
2.83
experimental
10.1261/rna.079709.123
Trichoplusia ni
Homo sapiens
U7 snRNA-associated Sm-like protein LSm11
4
ADN
ADENOSINE
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CO)O)O)N
HSA
267.245
12,605
8K8J
ELECTRON MICROSCOPY
2023-07-30
2024-02-14
null
null
null
null
8K8J
1
2.88
experimental
10.1002/advs.202306311
Escherichia coli
Homo sapiens
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
1
J3O
Fenofibrate
CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(cc2)Cl
HSA
360.837
12,610
8RHB
ELECTRON MICROSCOPY
2023-12-15
2024-11-20
null
null
null
null
8RHB
6
3
experimental
10.1038/s41467-025-61498-3
Escherichia coli
Homo sapiens
Kif5b Tail
4
GDP
GUANOSINE-5'-DIPHOSPHATE
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
HSA
443.202
12,615
8W8B
ELECTRON MICROSCOPY
2023-09-01
2023-11-22
UJL
2,300
EC50
nM
8W8B
7
3
experimental
10.1038/s41586-023-06775-1
Spodoptera frugiperda
Escherichia coli, Homo sapiens
Soluble cytochrome b562,5-hydroxytryptamine receptor 1A
5
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
12,620
8XXV
ELECTRON MICROSCOPY
2024-01-19
2024-12-04
null
null
null
null
8XXV
2
2.33
experimental
10.1073/pnas.2403304121
Trichoplusia ni
Mus musculus
scFv16
5
A1D5Q
[(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{Z})-octadec-9-enoate
CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC(=O)CCCCCCCC=CCCCCCCCC
HSA
837.082
12,625
9OCO
ELECTRON MICROSCOPY
2025-04-24
2025-12-17
null
null
null
null
9OCO
1
2.95
experimental
10.1038/s41467-025-68226-x
null
Homo sapiens
2E1 Light Chain
6
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
12,631
9VG0
X-RAY DIFFRACTION
2025-06-12
2025-09-24
null
null
null
null
9VG0
7
1.61
experimental
10.1039/d5cb00169b
null
Homo sapiens
Histone H3.1
2
MYR
MYRISTIC ACID
CCCCCCCCCCCCCC(=O)O
HSA
228.376
12,634
9VGZ
X-RAY DIFFRACTION
2025-06-15
2025-09-24
null
null
null
null
9VGZ
5
2.34
experimental
10.1039/d5cb00169b
null
Homo sapiens
Histone H3.1
2
NAD
NICOTINAMIDE-ADENINE-DINUCLEOTIDE
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
HSA
663.43
12,639
9VH0
X-RAY DIFFRACTION
2025-06-16
2025-09-24
null
null
null
null
9VH0
6
2.41
experimental
10.1039/d5cb00169b
null
Homo sapiens
Histone H3.1
2
NAD
NICOTINAMIDE-ADENINE-DINUCLEOTIDE
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
HSA
663.43
12,642
1ERE
X-RAY DIFFRACTION
1997-09-08
1998-09-16
EST
4
IC50
nM
1ERE
6
3.1
experimental
10.1038/39645
Escherichia coli
Homo sapiens
ESTROGEN RECEPTOR
1
EST
ESTRADIOL
CC12CCC3c4ccc(cc4CCC3C1CCC2O)O
HSA
272.388
12,763
2J7X
X-RAY DIFFRACTION
2006-10-17
2006-11-07
EST
7.9
Kd
nM
2J7X
7
2.1
experimental
null
null
Homo sapiens
NUCLEAR RECEPTOR COACTIVATOR 5
2
EST
ESTRADIOL
CC12CCC3c4ccc(cc4CCC3C1CCC2O)O
HSA
272.388
12,859
5DS3
X-RAY DIFFRACTION
2015-09-16
2016-07-27
09L
3.6
EC50
nM
5DS3
4
2.6
experimental
10.1016/j.molcel.2015.10.013
Escherichia coli
Homo sapiens
Poly [ADP-ribose] polymerase 1
1
1PE
PENTAETHYLENE GLYCOL
C(COCCOCCOCCOCCO)O
HSA
238.28
12,921
6MZQ
X-RAY DIFFRACTION
2018-11-05
2019-01-16
TZ0
2.2
IC50
nM
6MZQ
2
2
experimental
10.1002/cmdc.201800719
Escherichia coli BL21(DE3)
Homo sapiens
Fibroblast growth factor receptor 1
1
TZ0
1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one
COc1cc(cc(c1)OC)C#Cc2c3c(ncnc3n(n2)C4CCN(C4)C(=O)C=C)N
HSA
418.457
12,933
6MZW
X-RAY DIFFRACTION
2018-11-05
2019-01-16
TZ0
1
IC50
nM
6MZW
3
2.2
experimental
10.1002/cmdc.201800719
Escherichia coli
Homo sapiens
Fibroblast growth factor receptor 1
1
TZ0
1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one
COc1cc(cc(c1)OC)C#Cc2c3c(ncnc3n(n2)C4CCN(C4)C(=O)C=C)N
HSA
418.457
12,945
7E2X
ELECTRON MICROSCOPY
2021-02-07
2021-04-14
null
null
null
null
7E2X
14
3
experimental
10.1038/s41586-021-03376-8
Spodoptera frugiperda
Escherichia coli, Homo sapiens
Soluble cytochrome b562,5-hydroxytryptamine receptor 1A
4
J40
[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate
CCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)OP(=O)(O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CC
HSA
854.905
12,949
7EW3
ELECTRON MICROSCOPY
2021-05-24
2021-09-29
S1P
2.4
EC50
nM
7EW3
5
3.1
experimental
10.1038/s41422-021-00567-w
Spodoptera frugiperda
Homo sapiens
Guanine nucleotide-binding protein G(i) subunit alpha-1
1
S1P
(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
CCCCCCCCCCCCCC=CC(C(COP(=O)(O)O)N)O
HSA
379.478
12,964
7VFX
ELECTRON MICROSCOPY
2021-09-14
2022-09-21
null
null
null
null
7VFX
4
2.8
experimental
10.1038/s41467-022-32822-y
Spodoptera frugiperda
Homo sapiens
fMet-Leu-Phe receptor
1
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
12,970
8AKA
X-RAY DIFFRACTION
2022-07-29
2023-08-16
null
null
null
null
8AKA
28
1.77
experimental
null
Escherichia coli
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6
1
AR6
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)O)O)O)O)O)N
HSA
559.318
12,972
8AKA
X-RAY DIFFRACTION
2022-07-29
2023-08-16
null
null
null
null
8AKA
28
1.77
experimental
null
Escherichia coli
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6
1
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247
12,977
8AKA
X-RAY DIFFRACTION
2022-07-29
2023-08-16
null
null
null
null
8AKA
28
1.77
experimental
null
Escherichia coli
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6
1
PGE
TRIETHYLENE GLYCOL
C(COCCOCCO)O
HSA
150.174
12,978
8CNO
X-RAY DIFFRACTION
2023-02-23
2024-03-06
null
null
null
null
8CNO
26
1.75
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6
1
AR6
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)O)O)O)O)O)N
HSA
559.318
12,980
8CNO
X-RAY DIFFRACTION
2023-02-23
2024-03-06
null
null
null
null
8CNO
26
1.75
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6
1
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247
12,981
8CNO
X-RAY DIFFRACTION
2023-02-23
2024-03-06
null
null
null
null
8CNO
26
1.75
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6
1
PG4
TETRAETHYLENE GLYCOL
C(COCCOCCOCCO)O
HSA
194.227
12,986
8CNO
X-RAY DIFFRACTION
2023-02-23
2024-03-06
null
null
null
null
8CNO
26
1.75
experimental
null
Escherichia coli BL21(DE3)
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6
1
PGE
TRIETHYLENE GLYCOL
C(COCCOCCO)O
HSA
150.174
12,987
8JT6
ELECTRON MICROSCOPY
2023-06-21
2024-02-28
null
null
null
null
8JT6
9
3
experimental
10.1016/j.cell.2024.02.034
Trichoplusia ni
Escherichia coli, Homo sapiens
Soluble cytochrome b562,5-hydroxytryptamine receptor 1A
5
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
12,994
8WW2
ELECTRON MICROSCOPY
2023-10-24
2024-02-14
null
null
null
null
8WW2
3
2.79
experimental
10.1038/s41422-024-00932-5
Spodoptera frugiperda
Homo sapiens
G-protein coupled receptor 3
5
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
12,999
9LSI
ELECTRON MICROSCOPY
2025-02-04
2025-03-12
null
null
null
null
9LSI
7
3.3
experimental
10.1016/j.str.2025.03.006
Trichoplusia ni
synthetic construct
Diabody (CitS VH-TLR3 VL)
2
CIT
CITRIC ACID
C(C(=O)O)C(CC(=O)O)(C(=O)O)O
HSA
192.123
13,003
9OD3
ELECTRON MICROSCOPY
2025-04-25
2025-12-17
null
null
null
null
9OD3
1
2.94
experimental
10.1038/s41467-025-68226-x
null
Homo sapiens
6B5 Light Chain
6
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,012
4PP6
X-RAY DIFFRACTION
2014-02-26
2014-05-07
null
null
null
null
4PP6
2
2.201
experimental
10.7554/eLife.02057
null
Homo sapiens
Nuclear receptor coactivator 2
2
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247
13,014
6MCZ
X-RAY DIFFRACTION
2018-09-03
2019-01-09
ACD
1,600
IC50
nM
6MCZ
2
2.1
experimental
10.7554/eLife.43320
Escherichia coli BL21(DE3)
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
ACD
ARACHIDONIC ACID
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O
HSA
304.474
13,015
7KK5
X-RAY DIFFRACTION
2020-10-27
2021-01-06
3JD
31,000
EC50
nM
7KK5
23
1.7
experimental
10.1074/jbc.RA120.016573
Spodoptera frugiperda
Homo sapiens
Poly [ADP-ribose] polymerase 1
1
3JD
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
c1cc2cn(nc2c(c1)C(=O)N)c3ccc(cc3)C4CCCNC4
HSA
320.396
13,031
7T6U
ELECTRON MICROSCOPY
2021-12-14
2022-03-30
null
null
null
null
7T6U
2
2.9
experimental
10.1038/s41467-022-28586-0
Spodoptera
Homo sapiens
Guanine nucleotide-binding protein G(i) subunit alpha-1
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,037
8E8R
ELECTRON MICROSCOPY
2022-08-25
2023-06-21
null
null
null
null
8E8R
1
2.66
experimental
10.1038/s41467-023-41052-9
Homo sapiens
Homo sapiens
9H2 Fab light chain
6
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,043
8ID9
ELECTRON MICROSCOPY
2023-02-12
2023-03-15
null
null
null
null
8ID9
1
3
experimental
10.1126/science.add6220
Spodoptera frugiperda
Homo sapiens
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
1
EPA
5,8,11,14,17-EICOSAPENTAENOIC ACID
CCC=CCC=CCC=CCC=CCC=CCCCC(=O)O
HSA
302.458
13,048
8W38
X-RAY DIFFRACTION
2024-02-22
2025-01-01
null
null
null
null
8W38
11
2.6
experimental
10.1016/j.annonc.2024.12.011
Escherichia coli
Homo sapiens
Fibroblast growth factor receptor 2
1
TZ0
1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one
COc1cc(cc(c1)OC)C#Cc2c3c(ncnc3n(n2)C4CCN(C4)C(=O)C=C)N
HSA
418.457
13,050
9E3M
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3M
43
2.48
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
GDP
GUANOSINE-5'-DIPHOSPHATE
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
HSA
443.202
13,052
9E3M
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3M
43
2.48
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
NAG
2-acetamido-2-deoxy-beta-D-glucopyranose
CC(=O)NC1C(C(C(OC1O)CO)O)O
HSA
221.209
13,053
9E3M
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3M
43
2.48
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
Y01
CHOLESTEROL HEMISUCCINATE
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C
HSA
486.737
13,054
9E3M
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3M
43
2.48
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,056
9E3N
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3N
39
2.95
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
NAG
2-acetamido-2-deoxy-beta-D-glucopyranose
CC(=O)NC1C(C(C(OC1O)CO)O)O
HSA
221.209
13,057
9E3N
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3N
39
2.95
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
GDP
GUANOSINE-5'-DIPHOSPHATE
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
HSA
443.202
13,059
9E3N
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3N
39
2.95
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,060
9E3N
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3N
39
2.95
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
ATP
ADENOSINE-5'-TRIPHOSPHATE
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
HSA
507.182
13,061
9PXV
ELECTRON MICROSCOPY
2025-08-06
2025-11-12
null
null
null
null
9PXV
3
3.02
experimental
10.1038/s41586-025-09677-6
Spodoptera frugiperda
Homo sapiens
Soluble cytochrome b562,Mu-type opioid receptor
5
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
13,066
9PXW
ELECTRON MICROSCOPY
2025-08-06
2025-11-12
null
null
null
null
9PXW
2
3.8
experimental
10.1038/s41586-025-09677-6
Spodoptera frugiperda
Homo sapiens
Soluble cytochrome b562,Mu-type opioid receptor
4
VSN
5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=S)(O)O)O)O)N=C(NC2=O)N
HSA
459.27
13,070
9PXY
ELECTRON MICROSCOPY
2025-08-06
2025-11-12
null
null
null
null
9PXY
4
3
experimental
10.1038/s41586-025-09677-6
Spodoptera frugiperda
Homo sapiens
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
4
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
13,074
3HM1
X-RAY DIFFRACTION
2009-05-28
2010-06-02
null
null
null
null
3HM1
2
2.33
experimental
null
null
Rattus norvegicus
Nuclear receptor coactivator 2
2
J3Z
(9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one
CC12CCC3c4ccc(cc4CCC3C1CCC2=O)O
HSA
270.372
13,076
4R6E
X-RAY DIFFRACTION
2014-08-25
2015-09-09
3JD
30
IC50
nM
4R6E
11
2.2
experimental
10.1021/acs.jmedchem.6b00990
Escherichia coli BL21(DE3)
Homo sapiens
Poly [ADP-ribose] polymerase 1
1
3JD
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
c1cc2cn(nc2c(c1)C(=O)N)c3ccc(cc3)C4CCCNC4
HSA
320.396
13,092
5HA9
X-RAY DIFFRACTION
2015-12-30
2016-03-09
null
null
null
null
5HA9
9
4.01
experimental
10.1038/s41598-016-0007-2
Escherichia coli K-12
Homo sapiens
Poly [ADP-ribose] polymerase 1
1
TP0
Amitriptyline
CN(C)CCC=C1c2ccccc2CCc3c1cccc3
HSA
277.411
13,111
7T6V
ELECTRON MICROSCOPY
2021-12-14
2022-03-30
null
null
null
null
7T6V
1
3.1
experimental
10.1038/s41467-022-28586-0
Spodoptera
Homo sapiens
N-formyl peptide receptor 2
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,117
7XT9
ELECTRON MICROSCOPY
2022-05-16
2022-07-27
SRO
1,049
Ki
nM
7XT9
7
3.2
experimental
10.1016/j.molcel.2022.05.031
Spodoptera frugiperda
Homo sapiens
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
1
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
13,156
8E8S
ELECTRON MICROSCOPY
2022-08-25
2023-06-21
null
null
null
null
8E8S
1
2.73
experimental
10.1038/s41467-023-41052-9
Homo sapiens
Homo sapiens
9H2 Fab light chain
6
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,162
8EF5
ELECTRON MICROSCOPY
2022-09-08
2022-11-09
7V7
0.051
Ki
nM
8EF5
12
3.3
experimental
10.1016/j.cell.2022.09.041
Escherichia coli
synthetic construct
scFv16
5
7V7
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
CCC(=O)N(c1ccccc1)C2CCN(CC2)CCc3ccccc3
HSA
336.479
13,199
8EF6
ELECTRON MICROSCOPY
2022-09-08
2022-11-09
MOI
1.6
IC50
nM
8EF6
12
3.2
experimental
10.1016/j.cell.2022.09.041
Spodoptera frugiperda
Homo sapiens
Mu-type opioid receptor
1
MOI
(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL
CN1CCC23c4c5ccc(c4OC2C(C=CC3C1C5)O)O
HSA
285.343
13,351
9E3O
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3O
48
2.76
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
A1BD8
(3s,5s,7s)-N'-(2-chlorophenyl)adamantane-1-carbohydrazide
c1ccc(c(c1)NNC(=O)C23CC4CC(C2)CC(C4)C3)Cl
HSA
304.821
13,352
9E3O
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3O
48
2.76
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
GDP
GUANOSINE-5'-DIPHOSPHATE
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
HSA
443.202
13,354
9E3O
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3O
48
2.76
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
NAG
2-acetamido-2-deoxy-beta-D-glucopyranose
CC(=O)NC1C(C(C(OC1O)CO)O)O
HSA
221.209
13,355
9E3O
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3O
48
2.76
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
Y01
CHOLESTEROL HEMISUCCINATE
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C
HSA
486.737
13,356
9E3O
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3O
48
2.76
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,357
9VEW
X-RAY DIFFRACTION
2025-06-10
2025-09-24
null
null
null
null
9VEW
6
2.68
experimental
10.1039/d5cb00169b
null
Homo sapiens
Histone H3.1
2
NAD
NICOTINAMIDE-ADENINE-DINUCLEOTIDE
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
HSA
663.43
13,362
2Z7X
X-RAY DIFFRACTION
2007-08-29
2007-10-02
null
null
null
null
2Z7X
6
2.1
experimental
10.1016/j.cell.2007.09.008
null
synthetic construct
Pam3CSK4
3
NAG
2-acetamido-2-deoxy-beta-D-glucopyranose
CC(=O)NC1C(C(C(OC1O)CO)O)O
HSA
221.209
13,365
3EPD
ELECTRON MICROSCOPY
2008-09-29
2008-11-11
null
null
null
null
3EPD
2
9
experimental
10.1073/pnas.0807848105
Escherichia coli
Poliovirus 3
protein VP3
6
SPH
SPHINGOSINE
CCCCCCCCCCCCCC=CC(C(CO)N)O
HSA
299.499
13,371
3FC6
X-RAY DIFFRACTION
2008-11-21
2009-02-10
LX2
14
EC50
nM
3FC6
4
2.063
experimental
10.1016/j.bmcl.2009.01.004
null
Mus musculus
Nr1h3 protein
2
REA
RETINOIC ACID
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
HSA
300.442
13,375
4ZO1
X-RAY DIFFRACTION
2015-05-05
2015-09-02
T3
0.68
Ki
nM
4ZO1
1
3.221
experimental
10.1038/ncomms9013
null
Homo sapiens
Retinoic acid receptor RXR-alpha
3
T3
3,5,3'TRIIODOTHYRONINE
c1cc(c(cc1Oc2c(cc(cc2I)CC(C(=O)O)N)I)I)O
HSA
650.976
13,397
6MD2
X-RAY DIFFRACTION
2018-09-03
2019-01-09
GW9
2
EC50
nM
6MD2
4
2.2
experimental
10.7554/eLife.43320
Escherichia coli BL21(DE3)
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
GW9
2-chloro-5-nitro-N-phenylbenzamide
c1ccc(cc1)NC(=O)c2cc(ccc2Cl)[N+](=O)[O-]
HSA
276.679
13,399
7W17
ELECTRON MICROSCOPY
2021-11-19
2022-01-19
null
null
null
null
7W17
1
2.5
experimental
10.1073/pnas.2118590119
Homo sapiens
Homo sapiens
VP4
4
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,403
7XT8
ELECTRON MICROSCOPY
2022-05-16
2022-07-27
SRO
330
Ki
nM
7XT8
8
3.1
experimental
10.1016/j.molcel.2022.05.031
Spodoptera frugiperda
Homo sapiens
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
1
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
13,442
8E8X
ELECTRON MICROSCOPY
2022-08-26
2023-06-21
null
null
null
null
8E8X
1
2.91
experimental
10.1038/s41467-023-41052-9
Homo sapiens
Homo sapiens
9H2 Fab light chain
6
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,448
8HA0
ELECTRON MICROSCOPY
2022-10-26
2022-12-21
null
null
null
null
8HA0
7
2.62
experimental
10.1038/s41401-022-01032-z
Trichoplusia ni
Homo sapiens
Parathyroid hormone/parathyroid hormone-related peptide receptor
6
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,454
8W3B
X-RAY DIFFRACTION
2024-02-22
2025-01-01
null
null
null
null
8W3B
7
2.23
experimental
10.1016/j.annonc.2024.12.011
Escherichia coli
Homo sapiens
Fibroblast growth factor receptor 2
1
TZ0
1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one
COc1cc(cc(c1)OC)C#Cc2c3c(ncnc3n(n2)C4CCN(C4)C(=O)C=C)N
HSA
418.457
13,456
9E3P
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3P
46
2.53
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
A1BD9
(1s,3R,4R,6r,8S,9S)-N'-(2-chlorophenyl)-3,4,8,9-tetramethyltetracyclo[4.4.0.0~3,9~.0~4,8~]decane-1-carbohydrazide
CC12CC3CC1(C4(C2(CC3(C4)C(=O)NNc5ccccc5Cl)C)C)C
HSA
358.913
13,457
9E3P
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3P
46
2.53
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
GDP
GUANOSINE-5'-DIPHOSPHATE
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
HSA
443.202
13,459
9E3P
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3P
46
2.53
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
NAG
2-acetamido-2-deoxy-beta-D-glucopyranose
CC(=O)NC1C(C(C(OC1O)CO)O)O
HSA
221.209
13,460
9E3P
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3P
46
2.53
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
Y01
CHOLESTEROL HEMISUCCINATE
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C
HSA
486.737
13,461
9E3P
ELECTRON MICROSCOPY
2024-10-23
2025-09-24
null
null
null
null
9E3P
46
2.53
experimental
10.1038/s41467-025-62643-8
Homo sapiens
Homo sapiens
P2X purinoceptor 7
1
PLM
PALMITIC ACID
CCCCCCCCCCCCCCCC(=O)O
HSA
256.43
13,463
9PXX
ELECTRON MICROSCOPY
2025-08-06
2025-11-12
null
null
null
null
9PXX
4
3.1
experimental
10.1038/s41586-025-09677-6
Spodoptera frugiperda
Homo sapiens
Soluble cytochrome b562,Mu-type opioid receptor
4
VSN
5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=S)(O)O)O)O)N=C(NC2=O)N
HSA
459.27
13,467
9VEM
X-RAY DIFFRACTION
2025-06-09
2025-09-24
null
null
null
null
9VEM
11
2.57
experimental
10.1039/d5cb00169b
null
Homo sapiens
Histone H3.1
2
NAD
NICOTINAMIDE-ADENINE-DINUCLEOTIDE
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
HSA
663.43
13,473
5Z56
ELECTRON MICROSCOPY
2018-01-17
2018-09-19
null
null
null
null
5Z56
21
5.1
experimental
10.1038/cr.2018.14
null
Homo sapiens
U5 snRNA
2
IHP
INOSITOL HEXAKISPHOSPHATE
C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O
HSA
660.03
13,522
5Z57
ELECTRON MICROSCOPY
2018-01-17
2018-09-19
null
null
null
null
5Z57
19
6.5
experimental
10.1038/cr.2018.14
null
Homo sapiens
Small nuclear ribonucleoprotein Sm D2
9
IHP
INOSITOL HEXAKISPHOSPHATE
C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O
HSA
660.03
13,572
1C5N
X-RAY DIFFRACTION
1999-12-22
2000-12-22
ESI
20,000
Ki
nM
1C5N
3
1.5
experimental
10.1016/S1074-5521(00)00104-6
null
Hirudo medicinalis
Hirudin
3
ESI
4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE
c1cc2c(cc(s2)C(=[NH2+])N)c(c1)I
HSA
303.148
13,596
3FAL
X-RAY DIFFRACTION
2008-11-17
2009-04-14
LO2
165
IC50
nM
3FAL
4
2.36
experimental
10.1021/jm800612u
Escherichia coli
Mus musculus
Oxysterols receptor LXR-alpha
2
REA
RETINOIC ACID
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
HSA
300.442
13,603
4JAZ
X-RAY DIFFRACTION
2013-02-19
2014-02-12
STL
77,100
EC50
nM
4JAZ
1
2.85
experimental
10.1002/cbic.201300754
Escherichia coli BL21(DE3)
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
STL
RESVERATROL
c1cc(ccc1C=Cc2cc(cc(c2)O)O)O
HSA
228.247
13,675
5DXG
X-RAY DIFFRACTION
2015-09-23
2016-07-27
EST
5.7
EC50
nM
5DXG
4
1.86
experimental
10.1002/anie.201510557
null
Homo sapiens
Stapled Peptide SRC2-P5
2
EST
ESTRADIOL
CC12CCC3c4ccc(cc4CCC3C1CCC2O)O
HSA
272.388
13,796
5HYR
X-RAY DIFFRACTION
2016-02-01
2016-05-25
EST
1.9
IC50
nM
5HYR
4
2.271
experimental
10.1002/anie.201510557
null
synthetic construct
Stapled Peptide SRC2-SP2
2
EST
ESTRADIOL
CC12CCC3c4ccc(cc4CCC3C1CCC2O)O
HSA
272.388
13,917
5LGD
X-RAY DIFFRACTION
2016-07-06
2016-08-31
null
null
null
null
5LGD
17
2.07
experimental
10.1038/ncomms12837
Homo sapiens
Homo sapiens
Platelet glycoprotein 4
1
NAG
2-acetamido-2-deoxy-beta-D-glucopyranose
CC(=O)NC1C(C(C(OC1O)CO)O)O
HSA
221.209
13,921
6MD4
X-RAY DIFFRACTION
2018-09-03
2019-01-09
BRL
26
EC50
nM
6MD4
2
2.24
experimental
10.7554/eLife.43320
Escherichia coli BL21(DE3)
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
BRL
2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)
CN(CCOc1ccc(cc1)CC2C(=O)NC(=O)S2)c3ccccn3
HSA
357.435
13,993
6PAV
X-RAY DIFFRACTION
2019-06-12
2020-03-11
null
null
null
null
6PAV
8
2.52
experimental
10.1038/s41467-020-14893-x
null
Homo sapiens
ARF6 peptide
3
COA
COENZYME A
CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCS)O
HSA
767.541
13,996
7AWC
X-RAY DIFFRACTION
2020-11-06
2020-11-25
BRL
14
EC50
nM
7AWC
6
1.74
experimental
10.1016/j.chembiol.2021.04.019
Escherichia coli BL21(DE3)
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
BRL
2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)
CN(CCOc1ccc(cc1)CC2C(=O)NC(=O)S2)c3ccccn3
HSA
357.435
14,067
7NEL
X-RAY DIFFRACTION
2021-02-04
2021-08-25
null
null
null
null
7NEL
23
1.45
experimental
10.1038/s41598-021-89785-1
null
Homo sapiens
Nuclear receptor coactivator 2
2
EST
ESTRADIOL
CC12CCC3c4ccc(cc4CCC3C1CCC2O)O
HSA
272.388
14,072
8F7W
ELECTRON MICROSCOPY
2022-11-20
2022-12-14
null
null
null
null
8F7W
5
3.19
experimental
10.1016/j.cell.2022.12.026
Escherichia coli
synthetic construct
scFv16
6
CLR
CHOLESTEROL
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
HSA
386.664
14,078
8W3D
X-RAY DIFFRACTION
2024-02-22
2025-01-01
null
null
null
null
8W3D
17
2.04
experimental
10.1016/j.annonc.2024.12.011
Escherichia coli
Homo sapiens
Fibroblast growth factor receptor 2
1
TZ0
1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one
COc1cc(cc(c1)OC)C#Cc2c3c(ncnc3n(n2)C4CCN(C4)C(=O)C=C)N
HSA
418.457
14,087
1GWR
X-RAY DIFFRACTION
2002-03-22
2002-08-29
null
null
null
null
1GWR
2
2.4
experimental
10.1074/JBC.M200764200
null
Homo sapiens
TRANSCRIPTION INTERMEDIARY FACTOR-2
2
EST
ESTRADIOL
CC12CCC3c4ccc(cc4CCC3C1CCC2O)O
HSA
272.388
14,089
2ACL
X-RAY DIFFRACTION
2005-07-19
2005-09-20
L05
50
EC50
nM
2ACL
8
2.8
experimental
10.1021/jm050532w
Escherichia coli
Mus musculus
Oxysterols receptor LXR-alpha
2
REA
RETINOIC ACID
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
HSA
300.442
14,093
3ADS
X-RAY DIFFRACTION
2010-01-29
2010-12-22
IMN
50,000
EC50
nM
3ADS
3
2.25
experimental
10.1038/emboj.2010.197
Escherichia coli
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
IMN
INDOMETHACIN
Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)O
HSA
357.793
14,094
3ADX
X-RAY DIFFRACTION
2010-01-29
2010-12-22
IMN
50,000
EC50
nM
3ADX
3
1.95
experimental
10.1038/emboj.2010.197
Escherichia coli
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
NRO
3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
CCCC(=Cc1ccc(o1)c2cccc(c2)C(=O)O)[N+](=O)[O-]
HSA
301.298
14,095
3ADX
X-RAY DIFFRACTION
2010-01-29
2010-12-22
IMN
50,000
EC50
nM
3ADX
3
1.95
experimental
10.1038/emboj.2010.197
Escherichia coli
Homo sapiens
Peroxisome proliferator-activated receptor gamma
1
IMN
INDOMETHACIN
Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)O
HSA
357.793