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metadata
license: cc0-1.0
configs:
  - config_name: data
    data_files:
      - split: XL_all
        path: data/XL_all-*
      - split: XL_inter
        path: data/XL_inter-*
      - split: XL_intra
        path: data/XL_intra-*
      - split: XL_Alkyne_BVSC
        path: data/XL_Alkyne_BVSC-*
      - split: XL_BS3
        path: data/XL_BS3-*
      - split: XL_DSBU_d12
        path: data/XL_DSBU_d12-*
      - split: XL_DSS
        path: data/XL_DSS-*
      - split: XL_DSSO
        path: data/XL_DSSO-*
      - split: XL_sulfo_SDA
        path: data/XL_sulfo_SDA-*
      - split: XL_TTD
        path: data/XL_TTD-*
      - split: XL_UCCL
        path: data/XL_UCCL-*
      - split: XL_VSD
        path: data/XL_VSD-*
      - split: XL_VTT
        path: data/XL_VTT-*
dataset_info:
  features:
    - name: Data Source
      dtype: string
    - name: Crosslinker
      dtype: string
    - name: Accession A
      dtype: string
    - name: Accession B
      dtype: string
    - name: Residue A
      dtype: int64
    - name: Residue B
      dtype: int64
    - name: XL Type
      dtype: string
    - name: XL Distance
      dtype: float64
  splits:
    - name: XL_all
      num_bytes: 5702295
      num_examples: 75038
    - name: XL_inter
      num_bytes: 1386289
      num_examples: 17264
    - name: XL_intra
      num_bytes: 1386289
      num_examples: 17264
    - name: XL_Alkyne_BVSC
      num_bytes: 6480
      num_examples: 80
    - name: XL_BS3
      num_bytes: 278709
      num_examples: 3793
    - name: XL_DSBU_d12
      num_bytes: 4446
      num_examples: 57
    - name: XL_DSS
      num_bytes: 879796
      num_examples: 12052
    - name: XL_DSSO
      num_bytes: 2720767
      num_examples: 35352
    - name: XL_sulfo_SDA
      num_bytes: 996190
      num_examples: 12610
    - name: XL_TTD
      num_bytes: 100302
      num_examples: 1374
    - name: XL_UCCL
      num_bytes: 214306
      num_examples: 2853
    - name: XL_VSD
      num_bytes: 287036
      num_examples: 3932
    - name: XL_VTT
      num_bytes: 214182
      num_examples: 2934
  download_size: 1448868
  dataset_size: 14177087
pretty_name: PRIDE Crosslinking Archive

PRIDE Crosslinking Archive

This dataset aggregates publicly available crosslinking mass spectrometry (XL-MS) datasets from the PRIDE repository. Each dataset is curated and categorized by crosslinking reagent a link type (inter-chain vs intra-chain). For intra-chain links where the protein can be mapped to a UniProt ID, each link is mapped onto the corresponding AlphaFold Database (AFDB) structure, and the Cα-Cα distance for the linked residue pair is reported.

The result is a standardized resource for analyzing XL-MS constraints across reagents and for benchmarking/evaluating integrative modeling pipelines.

Quickstart Usage

Install HuggingFace Datasets package

Each subset can be loaded into python using the Huggingface datasets library. First, from the command line install the datasets library

$ pip install datasets

Optionally set the cache directory, e.g.

$ HF_HOME=${HOME}/.cache/huggingface/
$ export HF_HOME

then, from within python load the datasets library

>>> import datasets

Load model datasets

To load one of the PRIDE_Crosslinking_Archive datasets, use datasets.load_dataset(...)