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NCT02203903
|
8:41:chronic_disease
|
Active Bronchiolitis obliterans syndrome
| 1
|
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NCT02880215
|
21:31:chronic_disease
|
moderate or greater depression symptoms
| 1
|
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0,
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NCT02531932
|
71:95:treatment
|
Patient should also avoid close contact with others who have received live attenuated vaccines
| 1
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NCT03137771
|
20:36:treatment,38:68:treatment,74:79:cancer
|
Patients receiving targeted therapy (non-cytotoxic systemic therapy) for NSCLC in the first-line setting
| 1
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NCT03065465
|
32:44:chronic_disease
|
Presence of a benign appearing peptic ulcer
| 1
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NCT02924402
|
21:46:cancer,25:28:cancer,54:57:cancer
|
Diagnosis of either Non-CLL B cell malignancy or CLL/SLL
| 1
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NCT02910700
|
1:11:cancer,,121:130:treatment,,183:192:treatment
|
metastases have been treated and there is no magnetic resonance imaging (MRI) evidence of progression for 2 weeks after treatment is complete and within 14 days of the first dose of nivolumab administration
| 1
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NCT02487251
|
21:37:chronic_disease
|
Significant feeding/eating disorders that would preclude participation in the interventions
| 1
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NCT03121352
|
10:31:treatment
|
A second post-treatment biopsy will be offered but will not be mandated
| 1
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NCT01293214
|
20:30:treatment,,
|
Time elapsed since amputation more than 6 months but less than 15 years
| 1
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NCT01670877
|
77:93:chronic_disease,106:130:chronic_disease,132:156:chronic_disease,158:176:chronic_disease,181:218:chronic_disease
|
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
| 1
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NCT01953588
|
10:23:cancer,,,,,,
|
Invasive breast cancer is estrogen receptor positive with an Allred score of 6, 7 or 8 by local institution standard protocol. If an Allred Score is not reported on the diagnostic pathology report, ER positivity in > 66% cells
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NCT02353728
|
1:19:treatment,35:60:treatment,,89:98:treatment
|
Previous treatment with any other tyrosine kinase inhibitor except for up to 2 weeks of nilotinib
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NCT00630253
|
1:22:cancer,29:76:cancer,,96:99:treatment
|
Malignant solid tumor (e.g. squamous cell carcinoma of the head/neck/cervix) within 2 years of HCT
| 1
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NCT02153229
|
,62:74:treatment
|
Subjects who have received more than 2 doses of neo-adjuvant chemotherapy
| 1
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NCT02579044
|
130:138:chronic_disease,153:165:chronic_disease,167:183:chronic_disease,185:204:chronic_disease,206:219:chronic_disease,223:236:chronic_disease,245:270:chronic_disease
|
Other concurrent severe and/or uncontrolled medical disease that could compromise participation in the study (i.e., uncontrolled diabetes, uncontrolled hypertension, severe infection, severe malnutrition, chronic liver or renal disease, active upper GI tract ulceration)
| 1
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NCT02780401
|
,35:62:treatment,64:76:treatment,78:97:treatment,111:127:treatment
|
Patients must be at least 28 days post cytotoxic chemotherapy, radiotherapy, monoclonal antibody and/or other biologic therapy, prior to enrollment
| 1
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NCT01532687
|
1:16:chronic_disease
|
Unstable angina
| 1
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NCT02312245
|
83:110:treatment
|
Uncontrolled intercurrent illness judged by the treating investigator to preclude treatment with chemotherapy
| 1
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NCT01101451
|
31:46:cancer,,,58:81:cancer,83:106:cancer,110:124:cancer,167:179:treatment,185:207:treatment
|
Pathologically proven primary cervical cancer I-IIA with squamous cell carcinoma, adenosquamous carcinoma or adenocarcinoma initially treated with a standard radical hysterectomy with pelvic lymphadenectomy
| 1
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NCT01782599
|
30:53:chronic_disease,55:68:chronic_disease,70:94:chronic_disease,96:112:chronic_disease,114:133:chronic_disease
|
lifetime DSM-IV diagnosis of organic mental disorder, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorder
| 1
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NCT02392572
|
,67:73:treatment
|
Pregnant and nursing patients are excluded because the effects of ONC201on a fetus or nursing child are unknown
| 1
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NCT02163317
|
,,139:156:treatment
|
willing and able to complete the Expanded Prostate Cancer Index Composite (EPIC) questionnaire (baseline, 6, 12 and 24 months post end of radiation therapy)
| 1
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NCT02315196
|
1:19:chronic_disease,23:38:chronic_disease,32:38:chronic_disease,,,,128:141:chronic_disease,184:207:chronic_disease,232:251:chronic_disease,253:269:chronic_disease,321:341:treatment,354:368:chronic_disease,372:410:chronic_disease
|
Myocardial infarct or unstable angina within 6 months before enrollment, New York Heart Association (NYHA) class II or greater heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, clinically significant pericardial disease, valvular disease with documented compromise in cardiac function, or electrocardiographic evidence of acute ischemic or active conduction system abnormalities
| 1
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NCT02315196
|
,81:93:treatment
|
imaging must have been performed no greater than 30 days prior to initiation of chemotherapy
| 1
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NCT02913430
|
25:27:treatment,
|
The minimum duration of AI in the adjuvant setting is 2 years
| 1
|
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NCT01059786
|
1:7:chronic_disease,,
|
Anemia (Hgb less than 10g/dL)
| 1
|
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NCT02213289
|
21:31:treatment,35:51:treatment,59:76:cancer
|
Must be amenable to ultrasound or CT-guided biopsy of one metastatic lesion
| 1
|
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NCT00985205
|
10:30:treatment,
|
Received glutamine supplement for > 24 hrs prior to randomization
| 1
|
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NCT02273375
|
15:51:cancer
|
Patients with large-cell neuroendocrine carcinomas are not eligible
| 1
|
[
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NCT02531932
|
20:23:chronic_disease
|
A known history of HIV seropositivity
| 1
|
[
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[
0,
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2,
0
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NCT02453373
|
19:31:chronic_disease,,,,
|
Known preexisting coagulopathy, (INR > 1.3, PTT >1.5 x control)
| 1
|
[
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NCT03158974
|
14:23:treatment,,
|
Received any treatment for their EGW within 60 days of planned study enrollment
| 1
|
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NCT02159495
|
37:52:cancer
|
Research participants has undergone lymphodepletion
| 1
|
[
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0,
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3
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NCT02266745
|
1:17:chronic_disease,19:24:chronic_disease,29:45:chronic_disease,56:72:treatment
|
Active bacterial, viral, or fungal infection requiring systemic therapy
| 1
|
[
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NCT02291978
|
8:31:chronic_disease,33:46:chronic_disease,42:45:chronic_disease,
|
Severe cerebrovascular disease (multiple CVAs or CVA within 6 months)
| 1
|
[
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NCT02264678
|
22:28:cancer,,80:82:treatment,86:94:treatment
|
patients must have a tumour at least 1 cm in size that can be measured using a CT or MRI scan
| 1
|
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NCT02171104
|
1:25:chronic_disease
|
Niemann-Pick C subtype 2
| 1
|
[
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[
2,
2,
2,
2
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NCT00719888
|
28:54:treatment,58:83:treatment,102:117:treatment
|
Patients who have received Y-90 ibritumomab (Zevalin) or I-131 tostumomab (Bexxar), as part of their salvage therapy are not eligible for Regimen A
| 1
|
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NCT02901067
|
9:19:chronic_disease
|
Ongoing hemorrhage requiring blood product transfusion
| 1
|
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NCT01865162
|
96:103:chronic_disease,127:149:chronic_disease,151:156:chronic_disease,160:173:chronic_disease,191:204:chronic_disease,206:219:chronic_disease,221:234:chronic_disease,236:257:chronic_disease,265:298:chronic_disease,300:309:chronic_disease,311:331:chronic_disease,336:348:chronic_disease
|
Any systemic illness or unstable medical condition that might pose additional risk, including: cardiac, unstable metabolic or endocrine disturbances, renal or liver disease, past history of renal calculi, hyperuricemia, hypercalcemia, mitochondrial disease, known disorder of fatty acid metabolism, porphyria, carnitine deficiency and pancreatitis
| 1
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NCT02565199
|
12:22:chronic_disease,,
|
No current depression (score less than a 7 on the Hamilton Depression Rating Scale (HDRS))
| 1
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NCT03025139
|
,,46:59:cancer,,,,
|
Women diagnosed with early stage, resectable breast cancer (Stage 0, I, II, or III) prior to age 50, and are within 5 years of diagnosis
| 1
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NCT01734512
|
51:65:treatment
|
Patients who have been previously treated with an mTOR inhibitor
| 1
|
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NCT02819843
|
7:51:chronic_disease
|
Known human immunodeficiency virus (HIV) infection
| 1
|
[
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[
0,
2,
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2,
2,
0,
0
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NCT01873131
|
15:21:chronic_disease,46:83:chronic_disease,87:109:chronic_disease,121:138:chronic_disease,140:185:chronic_disease,187:208:chronic_disease,214:231:chronic_disease,270:277:allergy_name,338:351:allergy_name,355:369:allergy_name
|
Patients with asthma or a history of asthma, chronic obstructive pulmonary disease or cardiovascular disease, including sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, and cardiogenic shock; hypersensitivity to any component of timolol; and in those patients receiving systemic administration of beta-blockers or ace inhibitors
| 1
|
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NCT02469857
|
1:32:chronic_disease,,
|
Chronic neurological impairment that leads to a neuro mSOFA component ≥2
| 1
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NCT02775162
|
5:34:chronic_disease
|
has acute/fulminant liver failure
| 1
|
[
"has",
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"failure"
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[
0,
2,
2,
2
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NCT03153410
|
32:43:treatment
|
Patient's acceptance to have a core biopsy
| 1
|
[
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[
0,
0,
0,
0,
0,
0,
1,
1
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NCT02346201
|
3:13:treatment
|
A medication for apathy is appropriate, in the opinion of the study physician
| 1
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NCT02186418
|
49:69:chronic_disease,55:69:chronic_disease,80:98:treatment,285:294:treatment,300:327:treatment
|
Minimum of two episodes of clinically diagnosed acute chest syndrome requiring hospital admission, or one life threatening episode of acute chest syndrome requiring ICU admission for exchange transfusion and or intubation, or frequent acute chest syndrome episodes, which necessitate treatment with chronic transfusion therapy
| 1
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NCT01341080
|
23:32:chronic_disease
|
Significant degree of dysphagia
| 1
|
[
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[
0,
0,
0,
2
] |
NCT02124902
|
,,,,158:174:chronic_disease
|
Serum bilirubin within (or under ) normal limits (OR total bilirubin ≤ 3.0 x IULN with direct bilirubin within normal range in patients with well documented Gilbert Syndrome)
| 1
|
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NCT02323880
|
,,49:82:treatment
|
Hemoglobin >= 8.0 g/dL at baseline (may receive red blood cell [RBC] transfusions)
| 1
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NCT02512926
|
,,,,196:205:treatment
|
Male and female patients of child-bearing potential must agree to use an effective method of contraception approved by the investigator during the study and for a minimum of 3 months after study treatment
| 1
|
[
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NCT02043548
|
121:136:treatment
|
there are complications or circumstances that, in the clinical site investigator's opinion, necessitate the tapering of corticosteroids
| 1
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NCT00719888
|
,,97:109:treatment
|
ligible with (M2 marrow) with =< 25% blasts in marrow after having failed one or more cycles of chemotherapy
| 1
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NCT02253316
|
20:35:treatment,85:101:cancer,109:130:chronic_disease,132:152:chronic_disease
|
Patients may be on corticosteroids if they are being given for disorders other than multiple myeloma (e.g., adrenal insufficiency, rheumatoid arthritis, etc.)
| 1
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NCT02111824
|
15:32:chronic_disease,,,,,
|
Patients with liver dysfunction: total bilirubin > 2.5 mg/dl; albumin < 2.5 mg/dl; alanine aminotransferase (ALT), aspartate aminotransferase (AST) > 5 times upper limits of normal
| 1
|
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NCT02707692
|
11:40:treatment
|
Receiving immunosuppressive medications
| 1
|
[
"Receiving",
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[
0,
1,
1
] |
NCT01245712
|
8:30:cancer,32:47:cancer,51:55:cancer,,
|
Proven multicentric carcinoma (invasive cancer or DCIS) in more than one quadrant or separated by 4 or more centimeters
| 1
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NCT02094794
|
,,149:158:treatment
|
The time from the end last induction, re-induction, or consolidation regimen should be greater than or equal to 14 days from planned start of study treatment
| 1
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NCT03158519
|
13:40:chronic_disease
|
symptomatic peripheral vascular disease
| 1
|
[
"symptomatic",
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[
0,
2,
2,
2
] |
NCT02186418
|
20:23:treatment,43:63:treatment,67:78:treatment,134:146:treatment,213:219:chronic_disease
|
Patients with high TCD do equally well on chronic transfusions or hydroxyurea, as per a subsequent TWITCH study, where patients with elevated TCD were randomized to hydroxyurea or chronic transfusions to prevent stroke
| 1
|
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NCT02562235
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34:45:treatment,47:83:treatment,93:103:treatment,105:114:treatment,116:126:treatment,145:179:treatment,181:193:treatment,195:207:treatment,210:218:treatment,241:253:treatment
|
Concomitant use of the following medications: phosphodiesterase (PDE) 5 inhibitors (such as sildenafil, tadalafil, vardenafil) and non-specific phosphodiesterase (PDE) inhibitors (theophylline, dipyridamole), nitrates or NO donors (such as amyl nitrite) in any form
| 1
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NCT02740543
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,,28:46:treatment
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FEV1 <60% predicted normal pre-bronchodilator
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NCT02592551
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49:61:chronic_disease
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NCT02033941
|
16:37:chronic_disease
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No evidence of hepatic insufficiency
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NCT03058146
|
15:36:chronic_disease,38:51:chronic_disease,69:87:chronic_disease
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Chronic major psychiatric disorders (schizophrenia, major recurrent affective disorder)
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NCT01815359
|
46:56:cancer
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Presence of clinically apparent or suspected metastasis to sites other than lymph nodes or peritoneal surfaces
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NCT03008070
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12:60:treatment,,153:168:treatment,170:189:treatment,191:203:treatment,205:217:treatment,221:231:treatment,
|
History of gastrointestinal malabsorptive bariatric surgery within less than 5 years or ingestion of drugs known to produce hepatic steatosis including corticosteroids, high-dose estrogens, methotrexate, tetracycline or amiodarone in the previous 6 months
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NCT00209235
|
91:115:chronic_disease
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For the portion of the study in which growth hormone is used for participants who are not growth hormone deficient (ie., growth hormone sufficient)
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NCT02776761
|
26:48:treatment
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Ongoing participation in another clinical trial (subjects continuing through Day 365 will not join other new studies until their final visit)
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NCT02122172
|
14:34:chronic_disease,77:93:chronic_disease,107:131:chronic_disease,142:157:treatment,162:181:treatment
|
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or psychiatric illness/social situations that would limit compliance with study requirements
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NCT03096288
|
1:12:treatment
|
rivaroxaban
| 1
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[
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[
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NCT02088554
|
13:32:chronic_disease
|
Patient has hyperparathyroidism
| 1
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NCT02583893
|
13:21:cancer,41:65:treatment,94:111:cancer
|
Evidence of leukemia recurrence after a nadir bone marrow biopsy demonstrates no evidence of residual leukemia
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NCT02990481
|
60:90:cancer
|
Patients with histologically confirmed locally advanced or metastatic cholangiocarcinomas in Arm 3
| 1
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NCT02043548
|
22:34:chronic_disease,
|
Patients treated for tuberculosis with no recurrence in 3 years are permitted
| 1
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NCT02496585
|
38:57:treatment
|
Reduction of any acute toxicity from radiation treatment to grade 1
| 1
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NCT02451423
|
15:40:treatment,93:111:treatment,116:130:treatment
|
Subjects with malignant lymphadenectomy in the abdomen or pelvis considered appropriate for radical cystectomy and lymphadnectomy with the goal of complete resection of all malignant disease are allowed
| 1
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NCT02531932
|
1:7:chronic_disease,9:14:chronic_disease,18:25:chronic_disease,30:60:chronic_disease
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active (acute or chronic) or uncontrolled severe infections
| 1
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NCT02382419
|
,14:21:treatment,,111:126:treatment,111:114:chronic_disease,115:126:treatment,,342:352:treatment,,,478:486:treatment,,
|
Women in the vaccine-eligible age range cannot have received vaccine prior to enrollment, but will be offered HPV vaccination at the end of the study; in brief, we are interested in the efficacy of intervention in preventing HPV in the absence of HPV vaccination, since most women worldwide who might utilize intervention will not have been vaccinated; this includes United States (US) women in the vaccine catch-up 19-26 year old age group (beyond the age groups eligible for Vaccines for Children- funded vaccination) who have so far had very low (< 10%) vaccine uptake; it also includes the entire group of US women > 26 years of age; moreover, it includes women of all ages in developing countries, who most need an HPV prevention strategy, but may never be vaccinated; it should be noted that delaying vaccination in women 19-26 years of age by one year is safe and reasonable, since there is insufficient data to establish a recommendation for or against universal vaccination in this age group as concluded by an American Cancer Society expert panel, which includes the Principal Investigator (PI) of this protocol, Dr. Mark Einstein; it is anticipated that if the intervention gel is efficacious, HPV vaccinated women would need to be studied in a similar future trial with power analysis taking into account vaccine effectiveness as well
| 1
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NCT02536794
|
12:44:chronic_disease
|
History of primary immunodeficiency disease
| 1
|
[
"History",
"of",
"primary",
"immunodeficiency",
"disease"
] |
[
0,
0,
2,
2,
2
] |
NCT02133196
|
24:61:chronic_disease
|
Clinically significant atrial and/or ventricular arrhythmias
| 1
|
[
"Clinically",
"significant",
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"and/or",
"ventricular",
"arrhythmias"
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[
0,
0,
2,
2,
2,
2
] |
NCT01861106
|
32:55:chronic_disease
|
No history of life-threatening opportunistic infection
| 1
|
[
"No",
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"opportunistic",
"infection"
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[
0,
0,
0,
0,
2,
2
] |
NCT03035799
|
7:21:chronic_disease
|
Known Celiac disease
| 1
|
[
"Known",
"Celiac",
"disease"
] |
[
0,
2,
2
] |
NCT02344355
|
,33:42:treatment
|
Tolerate one test dose (15g) of ascorbate
| 1
|
[
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[
0,
0,
0,
0,
0,
0,
0,
0,
1
] |
NCT01872975
|
15:33:treatment,,
|
Patients with pathologic staging of ypN0(i+) or ypN0(mol+)
| 1
|
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NCT02525510
|
1:13:chronic_disease,15:38:chronic_disease,40:64:chronic_disease,79:93:chronic_disease
|
Coagulopathy, Hemodynamic instability, Electrolyte deficiencies, Pre-existing kidney disease (per study protocol)
| 1
|
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NCT02217709
|
77:93:chronic_disease,95:131:chronic_disease,133:157:chronic_disease,159:177:chronic_disease,182:201:chronic_disease
|
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
| 1
|
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"angina",
"pectoris",
",",
"cardiac",
"arrhythmia",
",",
"or",
"psychiatric",
"illness/social",
"situations",
"that",
"would",
"limit",
"compliance",
"with",
"study",
"requirements"
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
2,
2,
0,
2,
2,
2,
2,
0,
2,
2,
2,
0,
2,
2,
0,
0,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0
] |
NCT01807611
|
10:22:cancer
|
If prior CNS leukemia, it must be treated and in CNS CR
| 1
|
[
"If",
"prior",
"CNS",
"leukemia",
",",
"it",
"must",
"be",
"treated",
"and",
"in",
"CNS",
"CR"
] |
[
0,
0,
3,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
NCT02433977
|
31:49:allergy_name
|
Intolerance or allergy to the intervention drugs
| 1
|
[
"Intolerance",
"or",
"allergy",
"to",
"the",
"intervention",
"drugs"
] |
[
0,
0,
0,
0,
0,
4,
4
] |
NCT01842399
|
7:31:chronic_disease
|
Known congestive heart failure now or in the past
| 1
|
[
"Known",
"congestive",
"heart",
"failure",
"now",
"or",
"in",
"the",
"past"
] |
[
0,
2,
2,
2,
0,
0,
0,
0,
0
] |
NCT03053271
|
1:26:chronic_disease
|
cyclic Cushing's syndrome
| 1
|
[
"cyclic",
"Cushing",
"'s",
"syndrome"
] |
[
2,
2,
2,
0
] |
NCT02320292
|
,,127:136:treatment
|
of childbearing potential who are unwilling to employ adequate contraception for at least three months after completing study treatment
| 1
|
[
"of",
"childbearing",
"potential",
"who",
"are",
"unwilling",
"to",
"employ",
"adequate",
"contraception",
"for",
"at",
"least",
"three",
"months",
"after",
"completing",
"study",
"treatment"
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1
] |
NCT03000439
|
10:40:treatment
|
Previous JIA treatment with tofacitinib
| 1
|
[
"Previous",
"JIA",
"treatment",
"with",
"tofacitinib"
] |
[
0,
1,
1,
1,
1
] |
NCT02875405
|
18:30:chronic_disease
|
preoperative non-sinus rhythm
| 1
|
[
"preoperative",
"non-sinus",
"rhythm"
] |
[
0,
2,
2
] |
NCT03059407
|
18:22:allergy_name
|
known allergy to dogs
| 1
|
[
"known",
"allergy",
"to",
"dogs"
] |
[
0,
0,
0,
4
] |
NCT02466750
|
,,,88:97:treatment
|
Females must agree to not become pregnant for 3 months after receipt of the last study treatment (vaccination)
| 1
|
[
"Females",
"must",
"agree",
"to",
"not",
"become",
"pregnant",
"for",
"3",
"months",
"after",
"receipt",
"of",
"the",
"last",
"study",
"treatment",
"(",
"vaccination",
")"
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0
] |
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