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NCT02346526 | 29:33:cancer,,48:67:cancer,71:80:treatment,89:93:cancer,95:100:cancer,109:125:cancer,127:148:cancer | Bone-predominant metastatic CRPC: at least two skeletal metastases on bone scan with no lung, liver, and/or brain metastasis (lymph node metastasis is allowed) | 2 | [
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NCT02094794 | 43:72:treatment | All candidates for this study must have a human leukocyte antigen (HLA) (A, B, C, DR) identical siblings who is willing to donate bone marrow or primed blood stem cells or a 10/10 allele matched unrelated donor | 2 | [
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NCT01990209 | ,,,217:226:treatment,,274:284:treatment,332:367:treatment, | Female patients who are not of child-bearing potential and female patients of child-bearing potential who agree to use adequate contraceptive measures or abstain from heterosexual intercourse during the entire study treatment period and for 4 months after the last dose of study drug, who are not breastfeeding, and who ... | 2 | [
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NCT02421315 | 8:25:chronic_disease | Active suicidal ideation | 2 | [
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NCT02759120 | 32:45:allergy_name,50:62:allergy_name,64:76:allergy_name | Allergy or intolerance to both tetracyclines AND trimethoprim, sulfonamides or their combination | 2 | [
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NCT02356848 | 25:35:chronic_disease | Patients with an active foot ulcer | 2 | [
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NCT02753283 | 10:43:treatment,45:55:treatment,60:90:treatment,182:191:treatment | Those on hormone replacement therapy (HRT), raloxifene, or prescribed protective hip pads by their Primary Care Physician (PCP) will be allowed to participate and continue on these therapies | 2 | [
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NCT02070549 | 14:35:treatment,,,,168:178:treatment,234:260:treatment,268:317:treatment | Use of other investigational drugs within 28 days (or five half-lives, whichever is shorter; with a minimum of 14 days from the last dose) preceding the first dose of trametinib and during the study; patients previously treated with v-raf murine sarcoma (RAF) and/or mitogen-activated protein kinase (MEK) inhibitors | 2 | [
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NCT01624090 | 1:8:treatment,12:42:treatment,71:81:chronic_disease | Aspirin or salicylate-containing products, which may increase risk of hemorrhage | 2 | [
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NCT01572480 | 30:32:cancer | Patients with a diagnosis of MM as defined by the 2014 IMWH diagnostic criteria | 2 | [
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NCT02778282 | 45:59:chronic_disease,61:68:chronic_disease,70:75:chronic_disease,77:88:chronic_disease,90:99:chronic_disease,101:113:chronic_disease,118:139:chronic_disease,170:179:treatment, | Serious unstable medical illness including, cardiovascular, hepatic, renal, respiratory, endocrine, neurological, or hematological disease such that hospitalization for treatment of that illness is likely within the next 3 months | 2 | [
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NCT02905578 | 1:4:chronic_disease,37:44:treatment,88:108:treatment,123:140:treatment | HIV positive individuals undergoing therapy due to known drug:drug interaction between antiretroviral drugs and high-dose ascorbate therapy | 2 | [
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NCT02468453 | 75:92:chronic_disease,94:117:chronic_disease,132:154:chronic_disease | Subject is suffering from significant concurrent illness, such as such as cardiac disorders, diabetes (type I or II), or pertinent neurological disorders | 2 | [
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NCT03180086 | ,25:56:treatment | women with a history of breast enlargement or reduction | 2 | [
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NCT02291978 | 27:52:chronic_disease,56:59:treatment,97:115:chronic_disease,124:142:chronic_disease | Patients with evidence of lumbosacral radiculopathy on MRI or physical exam findings, including radicular leg pain, or any neurologic deficit at or below the segmental level of the highest facet to be treated, including subjects with impaired sphincter control | 2 | [
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NCT00065676 | 8:27:chronic_disease | severe diabetic neuropathy | 2 | [
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NCT02088554 | 1:47:chronic_disease | Hypertrophic obstructive cardiomyopathy (HOCM) | 2 | [
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NCT02566395 | 1:26:cancer | Acue myelogenous leukemia | 2 | [
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NCT02107703 | 15:48:treatment,61:72:treatment,74:95:treatment,98:109:treatment,111:121:treatment,130:146:treatment,207:249:treatment | Have received prior treatment with chemotherapy (except for neoadjuvant/ adjuvant chemotherapy), fulvestrant, everolimus, or any CDK4/6 inhibitor. For the endocrine naïve cohort: In addition, have received treatment with any prior endocrine therapy | 2 | [
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NCT01967823 | 39:49:treatment,101:112:treatment,125:141:treatment | Patients who have previously received ipilimumab and have documented GI toxicity must have a normal colonoscopy with normal colonic biopsies | 2 | [
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NCT01925573 | 12:31:chronic_disease,35:62:chronic_disease,64:70:chronic_disease,72:75:chronic_disease,89:116:chronic_disease | history of hypertensive crisis or hypertensive encephalopathy, stroke, TIA, symptomatic peripheral vascular disease | 2 | [
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NCT02473354 | 5:11:chronic_disease | has anemia [measured by venous blood gas sample] | 2 | [
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NCT02910700 | 75:84:allergy_name,86:96:allergy_name,101:111:allergy_name | History of allergy or adverse drug reaction to the study drug components (nivolumab, dabrafenib, or trametinib) or drugs of similar chemical or biologic composition | 2 | [
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NCT02579967 | 62:71:chronic_disease | Life-threatening, organ-threatening, or severely disfiguring infection | 2 | [
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NCT02312245 | 97:103:cancer | Willing to agree to periodic contact with a member of the study team during the period that the cancer has not recurred and/or has not become platinum resistant | 2 | [
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NCT02498951 | 1:32:treatment, | Vaccination with a live vaccine a minimum of 4 weeks prior to study enrollment | 2 | [
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NCT01270724 | 37:46:cancer,51:56:cancer,68:90:cancer,92:106:cancer,109:128:cancer,130:145:cancer,150:171:cancer | Patients with histologically proven germinoma and MMGCT, including endodermal sinus tumor (yolk sac tumor), embryonal carcinoma, choriocarcinoma and mixed germ cell tumor | 2 | [
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NCT02124772 | 35:63:chronic_disease | History of or current evidence of retinal vein occlusion (RVO) | 2 | [
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NCT03104205 | 1:9:chronic_disease | Dementia | 2 | [
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NCT02774642 | 47:51:chronic_disease | Veterans who are engaged in treatment for non-PTSD symptoms (e.g., 12-step programs) will be eligible | 2 | [
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NCT02339948 | 20:26:cancer,, | 2002 AJCC clinical cancer stage as determined by either urologist or radiation oncologist must be T1c - T2b, N0, M0 | 2 | [
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NCT02307565 | 12:40:chronic_disease | History of Traumatic Brain Injury (TBI) | 2 | [
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NCT02564796 | 15:38:chronic_disease | Newborns with acyanotic heart disease | 2 | [
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NCT02200445 | ,59:79:treatment,154:174:treatment,176:199:treatment,201:213:treatment,221:237:treatment,244:282:treatment | Failure to tolerate or failure to respond to at least one conventional therapy with the intention of inducing or maintaining remission (examples include oral corticosteroids, oral 5-aminosalicylates, azathioprine and/or 6-mercaptopurine, or a tumor necrosis factor (TNF) antagonist | 2 | [
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NCT02911831 | 72:88:chronic_disease,102:126:chronic_disease,128:151:chronic_disease,153:177:chronic_disease,179:197:chronic_disease,202:221:chronic_disease | Uncontrolled current illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, subarachnoid hemorrhage, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements | 2 | [
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NCT02719327 | 6:26:chronic_disease | mild cognitive impairment on screening evaluation | 2 | [
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NCT03016871 | ,,109:120:chronic_disease | women who are not of childbearing potential (i.e., who are postmenopausal or surgically sterile) as well as azoospermic men do not require contraception | 2 | [
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NCT01367444 | ,,,,114:123:treatment | Reduction in macular mean sensitivity of ≥5 dB or reduction in hill of vision by >14 dB-sr as assessed by static perimetry | 2 | [
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NCT02913430 | 33:84:treatment | There is no minimum duration of AI in the metastatic setting or neoadjuvant setting | 2 | [
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NCT02408861 | 23:37:cancer,,174:198:treatment,200:208:treatment,213:244:treatment | for participants with Kaposi sarcoma, the following apply: at least five measurable cutaneous KS lesions or any number of lesions with systemic unresectable disease with no previous local radiation, surgical, or intralesional cytotoxic therapy that would prevent response assessment | 2 | [
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NCT02541565 | 20:36:chronic_disease,53:77:treatment,99:124:treatment,,172:181:treatment | Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment | 2 | [
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NCT02021604 | 15:17:chronic_disease | Patients with HI attending the Cook Children's Congenital Hyperinsulinism Center and being treated by an Endocrinologist which may be the PI or a partner of this clinician | 2 | [
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NCT02466009 | 36:52:treatment | Must be able to swallow and retain oral medications | 2 | [
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NCT01532687 | 1:13:treatment,15:28:treatment,30:46:treatment,48:71:treatment,75:91:treatment | Chemotherapy, immunotherapy, biologic therapy, investigational therapy or hormonal therapy | 2 | [
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NCT02639390 | 19:54:treatment | Receiving oral or injected antispasticity medications during study treatment | 2 | [
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NCT02310464 | 15:32:chronic_disease,40:47:chronic_disease,56:66:cancer,78:90:chronic_disease, | Subjects with pleural effusions and/or ascites, due to malignancy, requiring paracentesis every 2 weeks or more frequently | 2 | [
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NCT02059239 | 1:28:treatment | Prior autologous transplant | 2 | [
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NCT01130077 | 42:64:treatment | Patients in Stratum F must have received craniospinal radiation | 2 | [
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NCT02520011 | 31:69:chronic_disease | Have evidence of uncontrolled disseminated intravascular coagulation | 2 | [
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NCT01912612 | 12:28:chronic_disease | History of seizure disorder | 2 | [
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NCT02181257 | ,60:63:chronic_disease | History of close FEV1 monitoring prior to diagnosis of new BOS defined as having had either of the two monitoring approaches | 2 | [
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NCT02914483 | 26:40:chronic_disease | chronic elevation due to kidney disease | 2 | [
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NCT02515110 | 32:44:treatment,49:60:cancer,64:100:cancer,119:137:cancer,151:173:treatment | Any history, not including the index cancer, of ipsilateral or contralateral invasive breast cancer or ipsilateral or contralateral DCIS treated with radiation therapy (RT) | 2 | [
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NCT01625234 | 15:33:cancer | Patients with primary CNS tumors | 2 | [
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NCT02974257 | 1:15:chronic_disease,, | Cardiac arrest occurring while admitted to the hospital, with sustained (>20 minutes) return of spontaneous circulation (ROSC) | 2 | [
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NCT01952730 | 27:95:cancer | Histologically documented hepatic colorectal cancer metastasis with resectable hepatic lesions | 2 | [
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NCT02624765 | 1:4:chronic_disease | SVT with fetal hydrops (irrespective of duration) | 2 | [
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NCT02107703 | 32:84:treatment, | approved Receptor activator of nuclear factor kappa-B (RANK) ligand targeted agents <7 days prior to randomization | 2 | [
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NCT02128906 | 19:32:treatment,95:100:cancer,108:121:cancer | Diagnostic simple tonsillectomy is permitted, provided patient has RECIST-measurable residual tumor and/or nodal disease | 2 | [
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NCT02516241 | 37:65:treatment | Patients eligible or ineligible for cisplatin-based chemotherapy | 2 | [
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NCT02554253 | 26:48:treatment | procedures not requiring cardiopulmonary bypass | 2 | [
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NCT00737893 | 30:48:chronic_disease | The patient has a history of sickle cell anemia | 2 | [
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NCT02494869 | 13:28:cancer | Any current invasive cancer diagnosis | 2 | [
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NCT03038269 | 1:24:treatment, | Botulinum toxin therapy in either upper extremity during last 2 months, or planned during study period | 2 | [
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NCT01614990 | 7:29:treatment | other investigational agents (a wash-out period of five times the half life of drugs that prolong QT will be allowed with approval of prescriber) | 2 | [
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NCT01902810 | 1:11:cancer,33:42:treatment,57:73:treatment, | Malignancy currently undergoing treatment or history of cancer treatment within 5 years | 2 | [
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NCT02544503 | 8:20:chronic_disease | Normal neurological examination | 2 | [
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NCT01684904 | 1:16:treatment,21:38:cancer,42:66:treatment | Prior radiation for esophageal cancer or prior chest radiotherapy | 2 | [
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NCT02474927 | 8:31:chronic_disease | Active cytomegalovirus disease | 2 | [
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NCT02727062 | 44:53:chronic_disease | Physical exam demonstrating no preexisting mucositis | 2 | [
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NCT01349101 | 19:21:chronic_disease,,33:44:chronic_disease,66:76:treatment,89:98:treatment | For patients with RA or RARS or isolated 5q- they can proceed to transplant without any treatment | 2 | [
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NCT02493530 | 22:45:treatment,38:45:treatment,57:103:treatment,,126:141:treatment,,191:202:treatment | Patient has received wide field radiotherapy (including therapeutic radioisotopes such as strontium 89) ≤ 28 days or limited field radiation for palliation ≤ 14 days prior to starting trial medications or has not recovered from side effects of such therapy | 2 | [
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NCT02859142 | 8:28:chronic_disease | recent major cardiovascular event | 2 | [
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NCT00092222 | 21:31:cancer,50:59:treatment,108:118:treatment,168:171:chronic_disease | Presence of another malignancy requiring current treatment that would preclude the use of all of the study treatments or the ability to monitor the natural history of MCD untreated | 2 | [
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NCT02485639 | 18:27:allergy_name | known allergy to lidocaine | 2 | [
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NCT03129880 | 16:41:chronic_disease | Diagnosed with benign vocal fold lesions and/or hyper-function | 2 | [
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NCT02487095 | 38:60:treatment | Subjects who are receiving any other investigational agents | 2 | [
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NCT03153969 | 1:17:chronic_disease, | Cervical lesions must provide for a minimum of 1mm thickness of restorative material while maintaining natural tooth contour | 2 | [
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NCT01672138 | 27:44:treatment | Patients undergoing first catheter ablation for drug-refractory Persistent (PerAF) or long-standing persistent AF (LSPAF) | 2 | [
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NCT02628535 | ,85:94:chronic_disease,96:107:chronic_disease,188:204:chronic_disease,227:241:treatment,,286:307:chronic_disease | Clinically significant pulmonary compromise within 28 days of first dose, including pneumonia, pneumonitis, requirement for supplemental oxygen). use to maintain adequate oxygenation, or pleural effusion sufficient to warrant pleurocentesis or any history of ≥ Grade 3 drug induced or radiation pneumonitis | 2 | [
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NCT01554371 | 62:86:cancer | Patient must have histologically or cytologically documented solid tumor malignancies | 2 | [
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NCT02573376 | 12:31:treatment,36:48:treatment,86:95:chronic_disease | Receipt of prior HCV treatment and radiographic, histologic, or clinical evidence of cirrhosis | 2 | [
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NCT00788164 | 4:32:treatment,40:55:treatment,65:105:treatment,113:125:treatment, | No immunosuppressive medication (i.e., steroid therapy or other immunosuppressive/immunomodulating drugs [e.g., cyclosporine]) within the past 2 months | 2 | [
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NCT03065465 | 1:18:chronic_disease | anastomotic ulcer | 2 | [
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NCT02501096 | 47:57:cancer,67:78:cancer,112:121:treatment,136:145:treatment | Histologically and/or cytologically confirmed metastatic selected solid tumor types that have progressed after treatment with approved therapies or for which there are no standard effective therapies available | 2 | [
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NCT01703949 | 19:34:cancer,35:46:treatment,47:54:treatment,, | Resolution of all non-hematologic brentuximab vedotin-related adverse events (AEs) to < grade 2 | 2 | [
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NCT01850758 | 11:14:chronic_disease | A massive ACL tear or one that includes more than 2/3'rds of the ligament that's retracted | 2 | [
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NCT02091141 | 53:71:treatment,64:71:treatment,73:80:treatment,85:97:treatment,, | All non-hematological adverse events related to any prior chemotherapy, surgery, or radiotherapy must have resolved to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Grade less than or equal to (≤) 2 prior to starting therapy | 2 | [
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NCT01360606 | 11:29:cancer, | Extensive liver tumor burden, defined as more than 75% of the liver | 2 | [
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NCT02411773 | 1:20:chronic_disease,, | Metabolic Alkalosis (serum bicarbonate > 28 meq/L) | 2 | [
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NCT01787682 | 24:44:treatment, | Use of short course of oral corticosteroids within 4 weeks preceding first study day | 2 | [
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