qa_id stringlengths 27 27 | qa_group_id stringlengths 28 32 | qa_family stringclasses 3
values | subtask_type stringclasses 7
values | qa_subtype stringclasses 3
values | cluster_id stringclasses 42
values | language stringclasses 1
value | split stringclasses 1
value | question stringlengths 148 1.41k | answer stringlengths 718 10.8k | claim_ids listlengths 0 8 | paper_ids listlengths 1 5 | evidence_span_ids listlengths 0 7 | association_ids listlengths 0 4 | hypothesis_ids listlengths 0 4 | record_json stringlengths 4.37k 33.7k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
QA:0dace6b3a8753069d3d5c5c6 | QAG:f5729e4f3a00b55a4810e081 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Knockdown of GRB7 promoted cell apoptosis and re-sensitized CRC cells to MEKi by attenuating the efficient activation of the RTK pathway"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4829a77a6935fda7f37fc20b","quotes":["Knockdown of GRB7 induced cell apoptosis and re-sensitized CRC cells to MEKi... | [
"CLM:4829a77a6935fda7f37fc20b",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8732282"
] | [
"SPAN:6de01a540ebf467f890963b8"
] | [] | [] | {"qa_id":"QA:0dace6b3a8753069d3d5c5c6","qa_group_id":"QAG:f5729e4f3a00b55a4810e081","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Knockdown of GRB7 promoted cell apoptosis and re-sensitized CRC ce... |
QA:0e56361376c0bf7321a01841 | QAG:d6979691d886dc0fd1d38b63 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "KRAS wild-type state predicted survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return th... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4518a86909c95d8aecd48d25","quotes":["19. De Roock W, Piessevaux... | [
"CLM:4518a86909c95d8aecd48d25",
"CLM:3cd4082a1fbc3057f3124cf1",
"CLM:3807b7073be9625f65803816",
"CLM:60cd0128ecb2baee335356c9",
"CLM:513308b69f0351967d37a6ff",
"CLM:1f49030c58719ea8cbadf2bd"
] | [
"PMCID:PMC10721872",
"PMCID:PMC10803265",
"PMID:37870968",
"PMCID:PMC8590697"
] | [
"SPAN:f88dececbb1113617100b1b9",
"SPAN:1fcfd2bea6362815658b00af",
"SPAN:42b9db74ce87fa931f8ae655",
"SPAN:e9fcda7b9b8748b3e2289d20",
"SPAN:4fd73178d2846e134d78e377"
] | [
"ASC2:eed455081d47c4ba9eb67efb",
"ASC2:cc59101483bb417d0fbfd9f0",
"ASC2:80990dbe320414c27899d07c"
] | [
"HYP:DCH:0369f4f23fb2a3b40102852b",
"HYP:DCH:8368cc0445a9beef5b3aadc8"
] | {"qa_id":"QA:0e56361376c0bf7321a01841","qa_group_id":"QAG:d6979691d886dc0fd1d38b63","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"KRAS wild-type state predicted survival and is associated to early... |
QA:0f1eb7df57cc9fea57f977b8 | QAG:9dc60b20157eee9be2ab2c8e | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Additionally, in our study, we found that the cetuximab increased the cytotoxic effect of RSL3 on KRAS mutant CRC cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passa... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:cdfb42eb95b455a6f6a0d8d9","quotes":["Additionally, in our study, we found that the cetuximab enhanced the cytotox... | [
"CLM:cdfb42eb95b455a6f6a0d8d9",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC8590697"
] | [
"SPAN:3ed7efcb52f9a92c3409af57"
] | [] | [] | {"qa_id":"QA:0f1eb7df57cc9fea57f977b8","qa_group_id":"QAG:9dc60b20157eee9be2ab2c8e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Additionally, in our study, we found that the cetuximab increased ... |
QA:11ef5e6dc73d7a4da3e298f2 | QAG:54dedcb30ccd80643695c62e | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Second, differentiating subgroups on the basis of the combination of presence or absence of mutations and/or dMMR leads to increased statistical power, since most individual molecular features occurred in < 20% of CRC cases (e.g., MMR deficiency: 10.7%)"? Return the or... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d036b591a613914429322fdf","quotes":["Second, differentiating subgroups on the basis of the combination of presenc... | [
"CLM:d036b591a613914429322fdf",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9470639"
] | [
"SPAN:13619c83be7c427ee4642451"
] | [] | [] | {"qa_id":"QA:11ef5e6dc73d7a4da3e298f2","qa_group_id":"QAG:54dedcb30ccd80643695c62e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Second, differentiating subgroups on the basis of the combination ... |
QA:12ec44bcad1a5bd667f9b0b7 | QAG:68ef3cda912721ee4ca10bdf | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "These mutation led to the aberrant activation of the signaling pathways including the RAF/MEK/MAPK pathway, PI3K/Akt pathway and RAGDS, RAL-RLIP pathways, leading to the malignant CRC progression and development"? Return the original wording with paper, Claim, and Evid... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5b51a7d46a1b470e0451aedb","quotes":["These mutation leads to the aberrant activation of the signaling pathways in... | [
"CLM:5b51a7d46a1b470e0451aedb",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8934478"
] | [
"SPAN:5482885c9c81682bce594dcb"
] | [] | [] | {"qa_id":"QA:12ec44bcad1a5bd667f9b0b7","qa_group_id":"QAG:68ef3cda912721ee4ca10bdf","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"These mutation led to the aberrant activation of the signaling pat... |
QA:13990f975ddaee8546c0ddba | QAG:be401ecac306b855427da35d | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Mutations in the KRAS gene in pancreatic cancer (PDAC) have caused increased levels of this branched-chain amino acid"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f7758fafc6476c77f2c0075e","quotes":["Mutations in the KRAS gene in pancreatic cancer (PDAC) have caused elevated ... | [
"CLM:f7758fafc6476c77f2c0075e",
"CLM:02548fb255630e1212583b71"
] | [
"PMCID:PMC8616688"
] | [
"SPAN:57086ed575f508eeeb60d96f"
] | [] | [] | {"qa_id":"QA:13990f975ddaee8546c0ddba","qa_group_id":"QAG:be401ecac306b855427da35d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Mutations in the KRAS gene in pancreatic cancer (PDAC) have caused... |
QA:146ed6ad122916a850e323a2 | QAG:d5c3e439a95fd3dfa7baeb57 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "By analyzing the TCGA database, we found that high levels of GRB7 was associated with poor outcomes in CRC patients (Fig. 2F )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supportin... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f080099f451af7e1cc8beece","quotes":["By analyzing the TCGA database, we found that high levels of GRB7 were signi... | [
"CLM:f080099f451af7e1cc8beece",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8732282"
] | [
"SPAN:7ad352ffd024305f456ed388"
] | [] | [] | {"qa_id":"QA:146ed6ad122916a850e323a2","qa_group_id":"QAG:d5c3e439a95fd3dfa7baeb57","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"By analyzing the TCGA database, we found that high levels of GRB7 ... |
QA:1645d1191d0cde91ecd1f350 | QAG:5c4f02b74980405045d2c234 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Second, differentiating subgroups on the basis of the combination of presence or absence of mutations and/or dMMR led to increased statistical power, since most individual molecular features occurred in < 20% of CRC cases (e.g., MMR deficiency: 10.7%)"? Return the orig... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d8bbbc6876979b436414d7df","quotes":["Second, differentiating subgroups on the basis of the combination of presenc... | [
"CLM:d8bbbc6876979b436414d7df",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9470639"
] | [
"SPAN:13619c83be7c427ee4642451"
] | [] | [] | {"qa_id":"QA:1645d1191d0cde91ecd1f350","qa_group_id":"QAG:5c4f02b74980405045d2c234","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Second, differentiating subgroups on the basis of the combination ... |
QA:16c0a4f5ce5fdb6c0be6ba29 | QAG:90495f085cbba149c9852223 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "These results demonstrate that increased tumoral CKB mRNA and protein expression levels predicts enhanced responsiveness to SLC6A8 inhibition by RGX-202, consistent with CKB being an upstream component of the CKB/SLC6A8 phosphocreatine metabolic axis in CRC and a gene ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7256c89256967ee92fb866b5","quotes":["These results demonstrate that elevated tumoral CKB mRNA and protein express... | [
"CLM:7256c89256967ee92fb866b5",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:29a5bb53e4b0c68fc75d9fa7"
] | [] | [] | {"qa_id":"QA:16c0a4f5ce5fdb6c0be6ba29","qa_group_id":"QAG:90495f085cbba149c9852223","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"These results demonstrate that increased tumoral CKB mRNA and prot... |
QA:16fc018fe6d5d21084a65ac3 | QAG:66636764dc10e82d73d528eb | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In colorectal cancer, our model predicted that CMS4 tumors were not dependent on KRAS"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:66ec0ca784888b273e83a20a","quotes":["In colorectal cancer, our model predicted that CMS4 tumors were not dependen... | [
"CLM:66ec0ca784888b273e83a20a",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC10187917"
] | [
"SPAN:9765b54bb6b4609a115c582f"
] | [] | [] | {"qa_id":"QA:16fc018fe6d5d21084a65ac3","qa_group_id":"QAG:66636764dc10e82d73d528eb","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In colorectal cancer, our model predicted that CMS4 tumors were no... |
QA:1705672553d3f2fccda3e9c7 | QAG:dad4d69ce05322ffa6229705 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Furthermore, in previous findings, EPHA2 high and EFNA1 low expression in CRC patients was associated with reduced survival (Robertis et al. 2017 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: retur... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:624c1bf232e294b224960215","quotes":["Furthermore, in previous findings, EPHA2 high and EFNA1 low expression in CR... | [
"CLM:624c1bf232e294b224960215",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9931833"
] | [
"SPAN:e7720dd7d4772ac7069d8c0e"
] | [] | [] | {"qa_id":"QA:1705672553d3f2fccda3e9c7","qa_group_id":"QAG:dad4d69ce05322ffa6229705","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Furthermore, in previous findings, EPHA2 high and EFNA1 low expres... |
QA:178da297afe745fcd3322287 | QAG:9c4d313ad7a1871e9fef66be | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Moreover, the expression levels of CKB and SLC6A8 was associated with increased CRC metastasis in patients ( 15 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage wit... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:c1916d329418ca7b3dcad47d","quotes":["Moreover, the expression levels of CKB and SLC6A8 are associated with increa... | [
"CLM:c1916d329418ca7b3dcad47d",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:f65067bb28a1dfae57c8aeca"
] | [] | [] | {"qa_id":"QA:178da297afe745fcd3322287","qa_group_id":"QAG:9c4d313ad7a1871e9fef66be","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Moreover, the expression levels of CKB and SLC6A8 was associated w... |
QA:19aa12949b62a993e5db583b | QAG:88edd0b45481d5bc2bb21dea | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Our results showed that CTX did not effectively inhibit the PI3K/Akt pathway in KRAS -mutant CRC cells and that it was inhibited by combination treatment with PD and CTX"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenan... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b37c3a4c7196c9533697e700","quotes":["Our results showed that CTX did not effectively inhibit the PI3K/Akt pathway... | [
"CLM:b37c3a4c7196c9533697e700",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9646952"
] | [
"SPAN:785760352ad89af3ed582390"
] | [] | [] | {"qa_id":"QA:19aa12949b62a993e5db583b","qa_group_id":"QAG:88edd0b45481d5bc2bb21dea","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Our results showed that CTX did not effectively inhibit the PI3K/A... |
QA:19dcd740bc656e4a952521c1 | QAG:78cfb5680a3b15e854b8e455 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "For physical activity, the current results indicate a role of molecular features ( KRAS mut , PIK3CA mut , BRAF mut , and/or MMR deficiency) in the etiological pathway between physical inactivity and colon cancer risk in women (physical activity was associated with any... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:94c2ec6200ba1b1ddb556796","quotes":["For physical activity, the current results indicate a role of molecular feat... | [
"CLM:94c2ec6200ba1b1ddb556796",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9470639"
] | [
"SPAN:7409efd169c84009d2a70503"
] | [] | [] | {"qa_id":"QA:19dcd740bc656e4a952521c1","qa_group_id":"QAG:78cfb5680a3b15e854b8e455","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"For physical activity, the current results indicate a role of mole... |
QA:1c65a11da5a9b79a38438872 | QAG:5df244682630cf5d904b328e | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "However, addition of cetuximab to AZ’1569 only led to potent increases in cell death in three of seven KRAS G12C MT colorectal cancer models"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the e... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:ea5672e3ca4128dffe7f4a26","quotes":["However, addition of cetuximab to AZ’1569 only resu... | [
"CLM:ea5672e3ca4128dffe7f4a26",
"CLM:1cba67a12cdd2f006af7d9e3",
"CLM:0c691487875305cd83b08334",
"CLM:178d3dfe9b9beb6ba395173e",
"CLM:1f49030c58719ea8cbadf2bd"
] | [
"PMCID:PMC9808374",
"PMCID:PMC7611272",
"PMCID:PMC8590697"
] | [
"SPAN:93f53410008a73cf886081a7",
"SPAN:9e6dab9a2b19f6c6ef78d095",
"SPAN:cc8eb6cee7de699adf6a5aa9",
"SPAN:4fd73178d2846e134d78e377"
] | [
"ASC2:2aa8fcc8efedbbecf9255756",
"ASC2:9a6a2fbe5eb39bdc54e99616"
] | [
"HYP:DCH:6020f87951f6fed21ada72a1"
] | {"qa_id":"QA:1c65a11da5a9b79a38438872","qa_group_id":"QAG:5df244682630cf5d904b328e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"However, addition of cetuximab to AZ’1569 only led to potent incre... |
QA:1d8810bee006d7ea8af5019f | QAG:c0d1cb35f6dee60b867ee26d | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "A, KRASG12CMT colorectal cancer cells received increasing concentrations of AZ’1569 for 120 hours and cell viability determined using CTG assay"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return th... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:8e5b0b41d67a68fc2efc9cf8","quotes":["A, KRASG12CMT colorectal cancer cells were treated with increasing concentra... | [
"CLM:8e5b0b41d67a68fc2efc9cf8",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:3ba44bad176d3bd7bd69a9e9"
] | [] | [] | {"qa_id":"QA:1d8810bee006d7ea8af5019f","qa_group_id":"QAG:c0d1cb35f6dee60b867ee26d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"A, KRASG12CMT colorectal cancer cells received increasing concentr... |
QA:1f5a12e1a9e3de7620eea0d9 | QAG:35c5abc1cad5cce14bf9d487 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "ACC1 and FASN are involved in fatty acid synthesis and were decreased by mutant K-Ras protein in this pancreatic cancer cell line"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact suppor... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:55e0765cb3287e53f9c24e73","quotes":["ACC1 and FASN are involved in fatty acid synthesis and were attenuated by mu... | [
"CLM:55e0765cb3287e53f9c24e73",
"CLM:02548fb255630e1212583b71"
] | [
"PMCID:PMC9339489"
] | [
"SPAN:079476f54a6f5919aad942c5"
] | [] | [] | {"qa_id":"QA:1f5a12e1a9e3de7620eea0d9","qa_group_id":"QAG:35c5abc1cad5cce14bf9d487","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"ACC1 and FASN are involved in fatty acid synthesis and were decrea... |
QA:20809e00078aa10b7f1a4609 | QAG:d9972b4450e8292a2082c200 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Patients who had symptomatic brain metastases or known leptomeningeal disease, prior treatment with KRAS G12C inhibitor, prior anticancer therapy or unresolved toxicities from prior anticancer therapies, or received radiotherapy within 14 days before study treatment in... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:78af6bf902ed1d5cd6e7c0da","quotes":["Patients who had symptomat... | [
"CLM:78af6bf902ed1d5cd6e7c0da",
"CLM:1cba67a12cdd2f006af7d9e3",
"CLM:80376b4edb77787d4a5f5dac",
"CLM:60cd0128ecb2baee335356c9",
"CLM:1cea4336fb1737a7b0a9361a",
"CLM:3807b7073be9625f65803816"
] | [
"PMCID:PMC9255981",
"PMCID:PMC9808374",
"PMID:37870968",
"PMCID:PMC10803265"
] | [
"SPAN:82af22e452fed4997190df8b",
"SPAN:9c20e32d1bc68df87e8fbe43",
"SPAN:42b9db74ce87fa931f8ae655",
"SPAN:d77dd331465f38eb94409a73",
"SPAN:fd9bebdd68e348d642134f6b",
"SPAN:1fcfd2bea6362815658b00af"
] | [
"ASC2:4394f9a6442e6068caff9c39",
"ASC2:996fcbadc6abdd17896c8cc2",
"ASC2:1caf940245beb618b86c8ca9"
] | [
"HYP:DCH:259d94b63adf8ab23726769f",
"HYP:DCH:fb96f5f2cfe8113879842810"
] | {"qa_id":"QA:20809e00078aa10b7f1a4609","qa_group_id":"QAG:d9972b4450e8292a2082c200","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Patients who had symptomatic brain metastases or known leptomening... |
QA:20b05533a1097a6d880c9fa3 | QAG:d69da4b94c06400b3f83a72d | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Three cohorts of CRC patients were included in our analysis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span references; assess t... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2d0d72d42f55aad61f0f0fe8","quotes":["Three cohorts of CRC patients were included in our analysis."],"citations":[... | [
"CLM:2d0d72d42f55aad61f0f0fe8",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:70e805b018c9ee182926c705"
] | [] | [] | {"qa_id":"QA:20b05533a1097a6d880c9fa3","qa_group_id":"QAG:d69da4b94c06400b3f83a72d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Three cohorts of CRC patients were included in our analysis\"? Ret... |
QA:2125626bfb1bf70765692232 | QAG:c80fd94e56e09fdae279eccb | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "To gain insights into the clinical significance of RyR2 upregulation, we analyzed TCGA CRC data and demonstrated that high expression of RyR2 in CRC patients led to a shorter survival time (hazard ratio [HR] = 1.8, P = 0.011; Fig. 1C ) as well as shorter disease‐free s... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:3f104c990ae454ec840f5383","quotes":["To gain insights into the clinical significance of RyR2 upregulation, we ana... | [
"CLM:3f104c990ae454ec840f5383",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC10061290"
] | [
"SPAN:b98c059cb238c1ff6ac1dfe3"
] | [] | [] | {"qa_id":"QA:2125626bfb1bf70765692232","qa_group_id":"QAG:c80fd94e56e09fdae279eccb","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"To gain insights into the clinical significance of RyR2 upregulati... |
QA:21a4a6ed01f94323d2a613ea | QAG:79eccda193e5080635f6cd79 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Moreover, compared with single-agent therapies, combining MEK1/2 degraders with lapatinib improved growth inhibition of MDR1-overexpressing KRAS-mutant colorectal cancer xenografts in mice"? Return the original wording with paper, Claim, and Evidence Span references.
... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:31f03171281ffa31adb20353","quotes":["Moreover, compared with single-agent therapies, combining MEK1/2 degraders w... | [
"CLM:31f03171281ffa31adb20353",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC9552188"
] | [
"SPAN:1c45172d16e8f48e4156907e"
] | [] | [] | {"qa_id":"QA:21a4a6ed01f94323d2a613ea","qa_group_id":"QAG:79eccda193e5080635f6cd79","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Moreover, compared with single-agent therapies, combining MEK1/2 d... |
QA:24f045b039b24312f0e64489 | QAG:dd9b5f9f7fd3c1b3671839e8 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "This KRAS related signature was correlated with worse prognosis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span references; asse... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:0bdf83fadc2bf7930aa810ae","quotes":["This KRAS related signature was significantly correlated with worse prognosi... | [
"CLM:0bdf83fadc2bf7930aa810ae",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC10721872"
] | [
"SPAN:77ddc87187eebe3e535a0dee",
"SPAN:93c1241a33e62f43e225f736"
] | [] | [] | {"qa_id":"QA:24f045b039b24312f0e64489","qa_group_id":"QAG:dd9b5f9f7fd3c1b3671839e8","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"This KRAS related signature was correlated with worse prognosis\"?... |
QA:24f61bc4496bd3bf3630c254 | QAG:1b5be661bc9b7a6010445798 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Our results showed that PD decreased the CTX resistance of two KRAS -mutant CRC cell lines, HCT116 and LoVo"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with pape... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b06f596d1fc1cb02828aeaca","quotes":["Our results showed that PD reduced the CTX resistance of two KRAS -mutant CR... | [
"CLM:b06f596d1fc1cb02828aeaca",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9646952"
] | [
"SPAN:ba37b48a58b9ce5c64f6b061"
] | [] | [] | {"qa_id":"QA:24f61bc4496bd3bf3630c254","qa_group_id":"QAG:1b5be661bc9b7a6010445798","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Our results showed that PD decreased the CTX resistance of two KRA... |
QA:252950517510c8b973196717 | QAG:7ab014f7d4dc410de76f79c0 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In women, non-occupational physical activity was associated with a decreased risk of overall colon cancer (Table 5 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:ad18954c7488fc70dab99480","quotes":["In women, non-occupational physical activity was associated with a decreased... | [
"CLM:ad18954c7488fc70dab99480",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9470639"
] | [
"SPAN:5b193c3618912378d6dc555f"
] | [] | [] | {"qa_id":"QA:252950517510c8b973196717","qa_group_id":"QAG:7ab014f7d4dc410de76f79c0","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In women, non-occupational physical activity was associated with a... |
QA:256bbea5742aacad71cd3052 | QAG:6b33104d9b47fb4c4c5eb9ae | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In patients with CRC who had not received prior KRAS G12C inhibitor treatment, single-agent divarasib achieved a response rate of 35.9% 11 , while the combination of divarasib and cetuximab achieved a response rate of 62.5%"? Return the original wording with paper, Cla... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:677fc7e0c78165b169232f4a","quotes":["In patients with CRC who had not received prior KRA... | [
"CLM:677fc7e0c78165b169232f4a",
"CLM:1cba67a12cdd2f006af7d9e3",
"CLM:d7f0ffba35977167f5288623"
] | [
"PMCID:PMC10803265",
"PMCID:PMC9646952"
] | [
"SPAN:e9fcda7b9b8748b3e2289d20",
"SPAN:aabbc66b10a0ee587d0910b4"
] | [
"ASC2:e0714b55105ae88ade18ae95"
] | [] | {"qa_id":"QA:256bbea5742aacad71cd3052","qa_group_id":"QAG:6b33104d9b47fb4c4c5eb9ae","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In patients with CRC who had not received prior KRAS G12C inhibito... |
QA:2764f57ca29d09b5fca0bbff | QAG:9040fa5d7be7906fd13f7e5f | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "RyR2 was upregulated in mCRC patients with KRAS mutation and its expression was associated with poor prognosis of CRC patients"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supportin... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:ea7e2952c8875cdecad06438","quotes":["RyR2 was upregulated in mCRC patients with KRAS mutation and its expression ... | [
"CLM:ea7e2952c8875cdecad06438",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC10061290"
] | [
"SPAN:d6ca384619f26ba2af04d1c1"
] | [] | [] | {"qa_id":"QA:2764f57ca29d09b5fca0bbff","qa_group_id":"QAG:9040fa5d7be7906fd13f7e5f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"RyR2 was upregulated in mCRC patients with KRAS mutation and its e... |
QA:27abeba4165bb610705546f0 | QAG:05dc04869e8e38bee597fd83 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "The cfDNA yield was higher than plasma from patients with lung cancer or colorectal carcinoma than in healthy controls"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passag... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:8ebc5885c2154e00a32dad05","quotes":["The cfDNA yield was higher in plasma from patients with lung cancer or color... | [
"CLM:8ebc5885c2154e00a32dad05",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8987589"
] | [
"SPAN:48b96362d1be79b5e282cb67"
] | [] | [] | {"qa_id":"QA:27abeba4165bb610705546f0","qa_group_id":"QAG:05dc04869e8e38bee597fd83","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"The cfDNA yield was higher than plasma from patients with lung can... |
QA:27e27128b9376efae49db4d9 | QAG:670a7848d56ce281fe6c0503 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "By analyzing this dataset, we found that RyR2 expression was higher than mCRC tissues than in primary CRC tissues (Fig. 1E )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a20376f66cb3a2ef8211ea86","quotes":["By analyzing this dataset, we found that RyR2 expression was significantly h... | [
"CLM:a20376f66cb3a2ef8211ea86",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC10061290"
] | [
"SPAN:8f364d3d2fbbf992fee0621b"
] | [] | [] | {"qa_id":"QA:27e27128b9376efae49db4d9","qa_group_id":"QAG:670a7848d56ce281fe6c0503","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"By analyzing this dataset, we found that RyR2 expression was highe... |
QA:2801cba0667abf1277f87bad | QAG:d669312270ebc560910652b6 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Collectively, these findings strongly suggest that cetuximab enhances RSL3 promoted ferroptosis in KRAS mutant CRC cell lines"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2388cd1096ac30a73fd38dd4","quotes":["Collectively, these findings strongly suggest that ... | [
"CLM:2388cd1096ac30a73fd38dd4",
"CLM:1cba67a12cdd2f006af7d9e3",
"CLM:677fc7e0c78165b169232f4a"
] | [
"PMCID:PMC8590697",
"PMCID:PMC10803265"
] | [
"SPAN:3e26915b0c569329001acf7f",
"SPAN:e9fcda7b9b8748b3e2289d20"
] | [
"ASC2:ee93be364fc56ff45bf359ad"
] | [
"HYP:DCH:fd4aeb082d1ae96ef2cd0b8f"
] | {"qa_id":"QA:2801cba0667abf1277f87bad","qa_group_id":"QAG:d669312270ebc560910652b6","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Collectively, these findings strongly suggest that cetuximab enhan... |
QA:2828a9ac61c85ac165d436a4 | QAG:adb8dd51742e2ed3d8b5ac5a | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "The expression of SPINK4 was a independent prognostic predictor, and the knockdown of SPINK4 increased the proliferation and migration of colon cancer cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requiremen... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:795c5da65fa381d6046b19ca","quotes":["The expression of SPINK4 was a independent prognostic predictor, and the kno... | [
"CLM:795c5da65fa381d6046b19ca",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC10721872"
] | [
"SPAN:a0d546e8bd0a7b5bbc5e8d1f"
] | [] | [] | {"qa_id":"QA:2828a9ac61c85ac165d436a4","qa_group_id":"QAG:adb8dd51742e2ed3d8b5ac5a","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"The expression of SPINK4 was a independent prognostic predictor, a... |
QA:286880118a483259e3de9634 | QAG:3776527d83e4b0eab4721392 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In contrast, 9-ING-41 markedly decreased the growth rate of the CRC organoids from Patient 1 by 44%–62% both alone ( p < .05) and in combination with the tested SoC drugs ( p < .05)"? Return the original wording with paper, Claim, and Evidence Span references.
Integra... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:0e82ddbf974a5d0c530a48c4","quotes":["In contrast, 9-ING-41 markedly reduced the growth rate of the CRC organoids ... | [
"CLM:0e82ddbf974a5d0c530a48c4",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC8696016"
] | [
"SPAN:79016a0c807f2f5477a3f653"
] | [] | [] | {"qa_id":"QA:286880118a483259e3de9634","qa_group_id":"QAG:3776527d83e4b0eab4721392","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In contrast, 9-ING-41 markedly decreased the growth rate of the CR... |
QA:29f2be8bad0ae286ff0d78f5 | QAG:68c120022b5e6856ca214e77 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Interestingly, we found that cetuximab promoted RSL3-induced ferroptosis in KRAS mutant CRC cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:240ee70e4c5e4fd3bcb421d5","quotes":["Interestingly, we found that cetuximab promoted RSL3-induced ferroptosis in ... | [
"CLM:240ee70e4c5e4fd3bcb421d5",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC8590697"
] | [
"SPAN:39ae57a66bdba5a3f399e66e"
] | [] | [] | {"qa_id":"QA:29f2be8bad0ae286ff0d78f5","qa_group_id":"QAG:68c120022b5e6856ca214e77","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Interestingly, we found that cetuximab promoted RSL3-induced ferro... |
QA:2c2470b49c62d39afdebc2cd | QAG:c7f592166acee19b78206bb5 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "The FH-FM CGDB includes 16,357 patients with a diagnosis of advanced NSCLC, 10,430 with metastatic CRC, and 4438 with metastatic PDAC who received care within the FH network between 01/2011-09/2021. Cohorts included in our analysis were limited to those who had tissue ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:937d755177e1d715b211ccaa","quotes":["The FH-FM CGDB includes 16,357 patients with a diagnosis of advanced NSCLC, ... | [
"CLM:937d755177e1d715b211ccaa",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9734185"
] | [
"SPAN:6d18dccaa621054a6bde6b73"
] | [] | [] | {"qa_id":"QA:2c2470b49c62d39afdebc2cd","qa_group_id":"QAG:c7f592166acee19b78206bb5","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"The FH-FM CGDB includes 16,357 patients with a diagnosis of advanc... |
QA:2e4a34162e07d0bbe5646a14 | QAG:f8432b4f00e6da9c35648270 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Antitumor efficacy was associated with enhanced tumor apoptosis and reduced tumor cell proliferation, consistent with previous findings supporting a critical role for creatine metabolism in CRC progression and hypoxic survival ( 15 )"? Return the original wording with ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7653071726a7c8bfeb7863cd","quotes":["Antitumor efficacy was associated with enhanced tumor apoptosis and reduced ... | [
"CLM:7653071726a7c8bfeb7863cd",
"CLM:55e0765cb3287e53f9c24e73"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:dfe97ccd7beffb188547537e"
] | [] | [] | {"qa_id":"QA:2e4a34162e07d0bbe5646a14","qa_group_id":"QAG:f8432b4f00e6da9c35648270","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Antitumor efficacy was associated with enhanced tumor apoptosis an... |
QA:2f8f63a33f5d65ed7306d2f0 | QAG:ad34b60b20bc342369c7cf05 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Analysis of intermediary metabolites showed that increased cholesterol biosynthesis drives GGPP accumulation in KRAS -mutant CRC cells and in tumors from Apc Min/+ Kras G12D/+ Villin-Cre mice"? Return the original wording with paper, Claim, and Evidence Span references... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:30a94d977e482bacd8e018d5","quotes":["Analysis of intermediary metabolites showed that increased cholesterol biosy... | [
"CLM:30a94d977e482bacd8e018d5",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:5b4cbfb0dcd5dd378235f160"
] | [] | [] | {"qa_id":"QA:2f8f63a33f5d65ed7306d2f0","qa_group_id":"QAG:ad34b60b20bc342369c7cf05","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Analysis of intermediary metabolites showed that increased cholest... |
QA:2fc6da1e320b93b28ef55817 | QAG:82b79199dffc3762a0a2ac3d | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "S17 , PCSK9 expression was correlated with cholesterol biosynthesis ( SREBP2 , HMGCR , FDFT1 , SQLE ), GGPS1 , and MEK-ERK ( CCND1 , CCNE1 ) in human CRC patients"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:39d9a05487738532e37dcb95","quotes":["As shown in Fig. S17 , PCSK9 expression is positively correlated with choles... | [
"CLM:39d9a05487738532e37dcb95",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:a366d30bc424b3f78215d076"
] | [] | [] | {"qa_id":"QA:2fc6da1e320b93b28ef55817","qa_group_id":"QAG:82b79199dffc3762a0a2ac3d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"S17 , PCSK9 expression was correlated with cholesterol biosynthesi... |
QA:30182ad47443d56f5adfcc46 | QAG:f006cd2f01f4d1283a6fcce5 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "6 Combined genetic or pharmacologic inhibition of PLK1 and MEKi treatment promoted apoptosis in KRAS mutant colon cancer cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supportin... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d75cd2e3e0a8df74b17319b6","quotes":["Fig. 6 Combined genetic or pharmacologic inhibition of PLK1 and MEKi treatme... | [
"CLM:d75cd2e3e0a8df74b17319b6",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC8732282"
] | [
"SPAN:8dab87e95127f5cbb288b60a"
] | [] | [] | {"qa_id":"QA:30182ad47443d56f5adfcc46","qa_group_id":"QAG:f006cd2f01f4d1283a6fcce5","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"6 Combined genetic or pharmacologic inhibition of PLK1 and MEKi tr... |
QA:30375893807c4d084b108774 | QAG:db9d54cafb6b010051e2a09d | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Its effects were stronger than those of knockdown of KRAS alone in colon cancer cells because silencing of KRAS by small interfering RNA (siRNA) did not improve the protein expression levels of AKT or ERKs"? Return the original wording with paper, Claim, and Evidence S... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a3d0f862bf378dad086b39e3","quotes":["Its effects were stronger than those of knockdown of KRAS alone in colon can... | [
"CLM:a3d0f862bf378dad086b39e3",
"CLM:a1552d3605252a136c5cd060"
] | [
"PMCID:PMC9507988"
] | [
"SPAN:79ee4092af24a17655b20871"
] | [] | [] | {"qa_id":"QA:30375893807c4d084b108774","qa_group_id":"QAG:db9d54cafb6b010051e2a09d","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Its effects were stronger than those of knockdown of KRAS alone in... |
QA:30a16b86d4ca06bea8b04be4 | QAG:bd9b57fea999a9fb438f5556 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "We treated murine KRAS wild-type MC38 CRC tumors with RGX-202-01 after volumes reached ~150 mm 3 and observed substantially inhibited tumor growth in this immunocompetent model ( Fig. 3B )"? Return the original wording with paper, Claim, and Evidence Span references.
... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4a6e246ce5b70c997700d35d","quotes":["We treated murine KRAS wild-type MC38 CRC tumors with RGX-202-01 after volum... | [
"CLM:4a6e246ce5b70c997700d35d",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:26b68b71ec41e1a128047493"
] | [] | [] | {"qa_id":"QA:30a16b86d4ca06bea8b04be4","qa_group_id":"QAG:bd9b57fea999a9fb438f5556","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"We treated murine KRAS wild-type MC38 CRC tumors with RGX-202-01 a... |
QA:30ed6fb615985efab81d66b3 | QAG:b6171b1acf8a0617e7a23d3f | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Targeting of PCSK9 in conjunction with statins inhibited growth of APC / KRAS -mutant CRC, suggesting that PCSK9 is a therapeutic target for a large subset of patients with CRC"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated p... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5abe4323c62b1f7221bd73f4","quotes":["Targeting of PCSK9 in conjunction with statins suppressed growth of APC / KR... | [
"CLM:5abe4323c62b1f7221bd73f4",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:bcfa9c33844a3176dfb008c0"
] | [] | [] | {"qa_id":"QA:30ed6fb615985efab81d66b3","qa_group_id":"QAG:b6171b1acf8a0617e7a23d3f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Targeting of PCSK9 in conjunction with statins inhibited growth of... |
QA:32d2ad491e94b7753d97835e | QAG:6cb51e74185b9c869663cd7f | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Moreover, GRB7 knockdown synergistically promoted cell apoptosis with AZD6244 treatment for 24 and 48 h in CRC cell lines (Fig. 3C–F , Supplementary Fig. S3D, E , and Table S2 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:e2b71541b86e188a4cde69ff","quotes":["Moreover, GRB7 knockdown synergistically induced cell apoptosis with AZD6244... | [
"CLM:e2b71541b86e188a4cde69ff",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8732282"
] | [
"SPAN:885eca00ff420e9ac7a639d6"
] | [] | [] | {"qa_id":"QA:32d2ad491e94b7753d97835e","qa_group_id":"QAG:6cb51e74185b9c869663cd7f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Moreover, GRB7 knockdown synergistically promoted cell apoptosis w... |
QA:34279b5c84b522ad920ceb2b | QAG:1754ad7eb6d157f3895b7a92 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Patients who were diagnosed with metastatic disease greater than 90 days prior to their first visit within the FH network or received their FMI report greater than 60 days after their last FH visit date were excluded to ensure all therapies received prior to CGP were c... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f0fafe3f51da8d0f1bfc9a29","quotes":["Patients who were diagnosed with metastatic disease greater than 90 days pri... | [
"CLM:f0fafe3f51da8d0f1bfc9a29",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9734185"
] | [
"SPAN:3ffb750f81c928e9b059c664",
"SPAN:6d18dccaa621054a6bde6b73"
] | [] | [] | {"qa_id":"QA:34279b5c84b522ad920ceb2b","qa_group_id":"QAG:1754ad7eb6d157f3895b7a92","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Patients who were diagnosed with metastatic disease greater than 9... |
QA:354d31fbe6b5642c869f6b9d | QAG:b06df7df305ca19eab32b652 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "This group, making up 3–5% of all cases of metastatic CRC (mCRC) was associated with an unfavorable prognosis , which has been linked to a reduced sensitivity to systemic treatment"? Return the original wording with paper, Claim, and Evidence Span references.
Integrat... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:839589d5e8cbf7603cf1c01c","quotes":["This group, making up 3–5% of all cases of metastatic CRC (mCRC), is associa... | [
"CLM:839589d5e8cbf7603cf1c01c",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8582471"
] | [
"SPAN:b05ac986ca10872dfd9d39de"
] | [] | [] | {"qa_id":"QA:354d31fbe6b5642c869f6b9d","qa_group_id":"QAG:b06df7df305ca19eab32b652","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"This group, making up 3–5% of all cases of metastatic CRC (mCRC) w... |
QA:37e8c499bc9e5499c6722bde | QAG:6f719e8dc8e183f579391bae | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Importantly, AZ’1569-R cells also showed markedly decreased sensitivity to the three chemotherapies used in colorectal cancer treatment"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:667174b3001937553a3781b1","quotes":["Importantly, AZ’1569-R cells also showed markedly reduced sensitivity to the... | [
"CLM:667174b3001937553a3781b1",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:567bf2ff3ef979e45508b15d"
] | [] | [] | {"qa_id":"QA:37e8c499bc9e5499c6722bde","qa_group_id":"QAG:6f719e8dc8e183f579391bae","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Importantly, AZ’1569-R cells also showed markedly decreased sensit... |
QA:382c0450d9430e2e6b37eb7b | QAG:eef82a31d43371b0731aa6b6 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "K20 model predicts that most of the colorectal cancer patients with KRAS mutation are KRAS-sensitive with some exceptions and the model prediction scores was associated with several TCGA expression subtypes"? Return the original wording with paper, Claim, and Evidence ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:1531f2e1c0cf08a9018f0357","quotes":["K20 model predicts that most of the colorectal cancer patients with KRAS mut... | [
"CLM:1531f2e1c0cf08a9018f0357",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC10187917"
] | [
"SPAN:d3fc7fe06f1e88273a951acf"
] | [] | [] | {"qa_id":"QA:382c0450d9430e2e6b37eb7b","qa_group_id":"QAG:eef82a31d43371b0731aa6b6","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"K20 model predicts that most of the colorectal cancer patients wit... |
QA:3991261baf194965cd1fad55 | QAG:1aa6efe15f9e4709f4887699 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "To identify key functional genes and/or targets that, when inhibited cooperate with KRAS G12C inhibition to decrease survival, and increase apoptosis in KRAS G12C MT colorectal cancer cells, we used an RNAi screening approach targeting proteins that lie at nodal points... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f4cc86d92a4bc1941c61bde7","quotes":["To identify key functional genes and/or targets that, when inhibited, cooper... | [
"CLM:f4cc86d92a4bc1941c61bde7",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:aa52365a884bb54e5d362fc5"
] | [] | [] | {"qa_id":"QA:3991261baf194965cd1fad55","qa_group_id":"QAG:1aa6efe15f9e4709f4887699","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"To identify key functional genes and/or targets that, when inhibit... |
QA:3fae13df3b85d69cb539cd26 | QAG:7a43b5b4c415872197294237 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "These results indicated that mutant KRAS was associated with the glutamine-dependent cell growth of pancreatic cancer cells"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting p... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:125bd56675f6596398baa1a9","quotes":["These results indicated that mutant KRAS was associated with the glutamine-d... | [
"CLM:125bd56675f6596398baa1a9",
"CLM:02548fb255630e1212583b71"
] | [
"PMCID:PMC9339489"
] | [
"SPAN:9ed60283b75cdd66af773875"
] | [] | [] | {"qa_id":"QA:3fae13df3b85d69cb539cd26","qa_group_id":"QAG:7a43b5b4c415872197294237","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"These results indicated that mutant KRAS was associated with the g... |
QA:3faf13431f952b7e2b40ef45 | QAG:613864cbcba7e3205ced28f9 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Consistent with our observations in mice where RGX-202-01–mediated suppression of creatine uptake in tumors and tissues led to increased circulating and urinary excretion levels of creatine, we observed that patient serum and urine creatine levels increased upon RGX-20... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:7c8224e7ee48afda4cb6b745","quotes":["Consistent with our observations in mice where RGX-202-01–mediated suppressi... | [
"CLM:7c8224e7ee48afda4cb6b745",
"CLM:03cfb269a9159ad24fb4ab8b"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:d3a77cd6d1d7c61eeac4317b"
] | [] | [] | {"qa_id":"QA:3faf13431f952b7e2b40ef45","qa_group_id":"QAG:613864cbcba7e3205ced28f9","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Consistent with our observations in mice where RGX-202-01–mediated... |
QA:41bf1f3cd34930f12289d136 | QAG:d08e0d472f82811ec7f827fb | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Collectively, the series of experiments revealed that the combination of CTX and PD effectively decreased tumor growth by decreasing cell proliferation (Ki67) and increasing cell death (apoptosis) in KRAS -mutant CRC cell lines"? Return the original wording with paper,... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a543bc77c849120a7bcd8517","quotes":["Collectively, the series of experiments revealed that the combination of CTX... | [
"CLM:a543bc77c849120a7bcd8517",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9646952"
] | [
"SPAN:e2a8f23b430891223765939c"
] | [] | [] | {"qa_id":"QA:41bf1f3cd34930f12289d136","qa_group_id":"QAG:d08e0d472f82811ec7f827fb","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Collectively, the series of experiments revealed that the combinat... |
QA:421b554d54b67cd3a8de6fc7 | QAG:1ab957e9ba4cc59635fcad85 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "I PCSK9 mRNA predicted poor patient survival in APC MUT KRAS MUT CRC ( n = 162) in TCGA cohort, but not in APC MUT KRAS WT CRC ( n = 206) or overall cohort ( n = 368)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:daafee1c79c68bf004e37dac","quotes":["I PCSK9 mRNA predicts poor patient survival in APC MUT KRAS MUT CRC ( n = 16... | [
"CLM:daafee1c79c68bf004e37dac",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:6f78001fbf2dcef9a3207711"
] | [] | [] | {"qa_id":"QA:421b554d54b67cd3a8de6fc7","qa_group_id":"QAG:1ab957e9ba4cc59635fcad85","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"I PCSK9 mRNA predicted poor patient survival in APC MUT KRAS MUT C... |
QA:4282ac74be0f78f7cdaf8923 | QAG:7309fdcbd5e422b6cc373002 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Patients with KRAS mutated metastatic colorectal cancer, treated with first-line Bevacizumab plus chemotherapy doublet were enrolled in this retrospective analysis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance req... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:404a37464fbb3708f3e57dd9","quotes":["Patients with KRAS mutated metastatic colorectal cancer, treated with first-... | [
"CLM:404a37464fbb3708f3e57dd9",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC8514824"
] | [
"SPAN:6123318ae943797ac54b0d97"
] | [] | [] | {"qa_id":"QA:4282ac74be0f78f7cdaf8923","qa_group_id":"QAG:7309fdcbd5e422b6cc373002","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Patients with KRAS mutated metastatic colorectal cancer, treated w... |
QA:42919a9d254a6582b4ea8165 | QAG:714bd2e2534433c037e50e60 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Combined ABT-737/AZ’1569 treatment resulted also in potent increases in apoptosis as indicated by increased PARP cleavage and caspase-9/8/3 processing in all KRAS G12C MT colorectal cancer cells ( Fig. 4C ; Supplementary Fig. S4F)"? Return the original wording with pap... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d5bcd63247b3e9a25013e063","quotes":["Combined ABT-737/AZ’1569 treatment resulted also in potent increases in apop... | [
"CLM:d5bcd63247b3e9a25013e063",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:e3db1be21e458687037cb1a9"
] | [] | [] | {"qa_id":"QA:42919a9d254a6582b4ea8165","qa_group_id":"QAG:714bd2e2534433c037e50e60","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Combined ABT-737/AZ’1569 treatment resulted also in potent increas... |
QA:43406b7c047b451af91ac229 | QAG:15e0993c94a52b395c0da206 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Recent significant advancements in the treatment of CRC have been achieved with new therapeutic approaches, which result from improved understanding of the molecular pathways involved in the development and progression of CRC"? Return the original wording with paper, C... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:47973935e6eee11d912ef612","quotes":["Colorectal cancer (CRC) is considered the most common type of cancer among m... | [
"CLM:47973935e6eee11d912ef612",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC6934288"
] | [
"SPAN:f7a4c056091ca0bf5a357be6"
] | [] | [] | {"qa_id":"QA:43406b7c047b451af91ac229","qa_group_id":"QAG:15e0993c94a52b395c0da206","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Recent significant advancements in the treatment of CRC have been ... |
QA:4447a3aadae59c837bf44716 | QAG:2fed80f96fe372171254cb73 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In a genetically engineered mouse model of KRAS-driven PDAC, inducible whole-body deletion of xCT led to significant tumor regression"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact su... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a1552d3605252a136c5cd060","quotes":["In a genetically engineered mouse model of KRAS-driven PDAC, inducible whole... | [
"CLM:a1552d3605252a136c5cd060",
"CLM:02548fb255630e1212583b71"
] | [
"PMCID:PMC9950476"
] | [
"SPAN:cb6c4897b75327ed96dbee4f"
] | [] | [] | {"qa_id":"QA:4447a3aadae59c837bf44716","qa_group_id":"QAG:2fed80f96fe372171254cb73","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In a genetically engineered mouse model of KRAS-driven PDAC, induc... |
QA:4587d4af5792ff401657f071 | QAG:f47ed34831e1f209de8896db | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "SPINK4 is abundantly expressed in goblet cells, and recent research found that the expression of serum SPINK4 in patients with colon cancer is increased with high diagnostic value 64"? Return the original wording with paper, Claim, and Evidence Span references.
Integr... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:e12f7a5ea33965f58d226909","quotes":["SPINK4 is abundantly expressed in goblet cells, and recent research found th... | [
"CLM:e12f7a5ea33965f58d226909",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC10721872"
] | [
"SPAN:0c8223364172a06dfc80cfbf"
] | [] | [] | {"qa_id":"QA:4587d4af5792ff401657f071","qa_group_id":"QAG:f47ed34831e1f209de8896db","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"SPINK4 is abundantly expressed in goblet cells, and recent researc... |
QA:45faf8ba5335b70dd69b5d9c | QAG:d2c2990d9959f57a4c1b2625 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Moreover, genetic modulation or pharmacological inhibition of Paks led to a robust impairment of KRAS-mut CRC cell proliferation"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact support... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:3971715559293d10ebfd023d","quotes":["Moreover, genetic modulation or pharmacological inhibition of Paks led to a ... | [
"CLM:3971715559293d10ebfd023d",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC10539494"
] | [
"SPAN:4a7740a9cb7425a26171f662"
] | [] | [] | {"qa_id":"QA:45faf8ba5335b70dd69b5d9c","qa_group_id":"QAG:d2c2990d9959f57a4c1b2625","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Moreover, genetic modulation or pharmacological inhibition of Paks... |
QA:47b811e97d4fc0f76f338e8f | QAG:ac9ac00f780aaf711c5cdac7 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Moreover, the antitumor activity of PEPD G278D is further increased by fluorouracil (5-FU), which is widely used in CRC treatment"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact suppor... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:abc3c42cb54c78e83770a930","quotes":["Moreover, the antitumor activity of PEPD G278D is further enhanced by fluoro... | [
"CLM:abc3c42cb54c78e83770a930",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9161494"
] | [
"SPAN:480df57f5dc7c664c8210c8f"
] | [] | [] | {"qa_id":"QA:47b811e97d4fc0f76f338e8f","qa_group_id":"QAG:ac9ac00f780aaf711c5cdac7","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Moreover, the antitumor activity of PEPD G278D is further increase... |
QA:47e4f07a5f279872f94464cd | QAG:409982130075d7b4e1f2ad28 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "PCSK9 overexpression predicted poor survival of APC / KRAS -mutant CRC patients"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:2e0136ec27d27ba2736c6e81","quotes":["PCSK9 overexpression predicts poor survival of APC / KRAS -mutant CRC patien... | [
"CLM:2e0136ec27d27ba2736c6e81",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:19b83e11ebd8ea85616b982c"
] | [] | [] | {"qa_id":"QA:47e4f07a5f279872f94464cd","qa_group_id":"QAG:409982130075d7b4e1f2ad28","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"PCSK9 overexpression predicted poor survival of APC / KRAS -mutant... |
QA:48dac69b02df584b7033f89b | QAG:fdecacb1858adc15c0a44e8c | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Recent significant advancements in the treatment of CRC have been achieved with new therapeutic approaches, which result from improved understanding of the molecular pathways involved in the development and progression of CRC"? Return the original wording with paper, C... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:e241202e677da0111215f99e","quotes":["Colorectal cancer (CRC) is considered the most common type of cancer among m... | [
"CLM:e241202e677da0111215f99e",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC6934288"
] | [
"SPAN:f7a4c056091ca0bf5a357be6"
] | [] | [] | {"qa_id":"QA:48dac69b02df584b7033f89b","qa_group_id":"QAG:fdecacb1858adc15c0a44e8c","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Recent significant advancements in the treatment of CRC have been ... |
QA:496729f5ab352473ca9ee567 | QAG:2dc716cb9a03fc3156f89625 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Here, we report results from arm C patients with CRC who received divarasib in combination with cetuximab, an EGFR inhibitor"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:46b5be9561d4f52309cd0886","quotes":["Here, we report results from arm C patients with CR... | [
"CLM:46b5be9561d4f52309cd0886",
"CLM:125bd56675f6596398baa1a9",
"CLM:f919c5d13335b1660a98a88c"
] | [
"PMCID:PMC10803265",
"PMCID:PMC9161494"
] | [
"SPAN:a73f0eb9cb958986b113eb07",
"SPAN:797bc99e27febbbc112b7928"
] | [
"ASC2:e68949718f87ca897dc31957"
] | [] | {"qa_id":"QA:496729f5ab352473ca9ee567","qa_group_id":"QAG:2dc716cb9a03fc3156f89625","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Here, we report results from arm C patients with CRC who received ... |
QA:4a49ca467f68b81202e1800d | QAG:2b4f7218da0f81070f584f9b | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Multivariate COX proportional hazards regression analysis showed that PCSK9 protein was a prognostic factor for APC / KRAS -mutant CRC in Hong Kong ( P < 0.005) and TCGA ( P < 0.05) cohorts (Fig. 6J and Tables S4 and S5 )"? Return the original wording with paper, Claim... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4c80f3dad2bd9ddd1947d10f","quotes":["Multivariate COX proportional hazards regression analysis showed that PCSK9 ... | [
"CLM:4c80f3dad2bd9ddd1947d10f",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:86311a44154b2e52fda3de1d"
] | [] | [] | {"qa_id":"QA:4a49ca467f68b81202e1800d","qa_group_id":"QAG:2b4f7218da0f81070f584f9b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Multivariate COX proportional hazards regression analysis showed t... |
QA:4d4e3fcb5e69050660106ac4 | QAG:a2c885033154d62085af0bba | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Here we demonstrated that CM MIR143#12, which exhibited high RNase resistance and antiproliferation activity against DLD-1 cells, induced apoptotic cell death in the colorectal and pancreatic cancer cell lines tested but did not improve the growth of normal karyotypic ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f4cf2048082877277350eba3","quotes":["Here we demonstrated that CM MIR143#12, which exhibited high RNase resistanc... | [
"CLM:f4cf2048082877277350eba3",
"CLM:02548fb255630e1212583b71"
] | [
"PMCID:PMC9507988"
] | [
"SPAN:3612c9312ba6efb8dfa9cd71"
] | [] | [] | {"qa_id":"QA:4d4e3fcb5e69050660106ac4","qa_group_id":"QAG:a2c885033154d62085af0bba","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Here we demonstrated that CM MIR143#12, which exhibited high RNase... |
QA:4f91b1a1df256f045795f816 | QAG:0490617ff8fc0a10ca77c966 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Taken together, high RyR2 expression in primary CRC tissue was correlated with serosa invasion and vascular tumor thrombus formation, and predicted a poor prognosis"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance re... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b24874adb96bb7534c38773d","quotes":["Taken together, high RyR2 expression in primary CRC tissue was correlated wi... | [
"CLM:b24874adb96bb7534c38773d",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC10061290"
] | [
"SPAN:72c095886123f9d978489506"
] | [] | [] | {"qa_id":"QA:4f91b1a1df256f045795f816","qa_group_id":"QAG:0490617ff8fc0a10ca77c966","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Taken together, high RyR2 expression in primary CRC tissue was cor... |
QA:4fefd79dc39cc11535d8a574 | QAG:8b5da926a13f312e72623fb5 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Although there has been a report that GPR155 expression is inhibited in neoplasm of the thyroid, hepatocellular carcinoma, and gastric cancer, implying a tumor suppressive function for this gene, the resistant role in lung cancer, however, was not reported ( 61 , 62 )"... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:3cd4082a1fbc3057f3124cf1","quotes":["Although there has been a report that GPR155 expression is suppressed in neo... | [
"CLM:3cd4082a1fbc3057f3124cf1",
"CLM:03cfb269a9159ad24fb4ab8b"
] | [
"PMCID:PMC8987589"
] | [
"SPAN:795b2cd5d90ee69dd46099a7"
] | [] | [] | {"qa_id":"QA:4fefd79dc39cc11535d8a574","qa_group_id":"QAG:8b5da926a13f312e72623fb5","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Although there has been a report that GPR155 expression is inhibit... |
QA:522cd869dc1b6b60fb6913c2 | QAG:5098302aacb21575375251e3 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Although each siRNA for KRAS , AKT , and ERK also inhibited cell growth in the colorectal cancer cell lines tested, the effectiveness of siR-KRAS at concentrations of less than 2 nM was apparent among the siRNAs tested ( Figures S1 B–S1E), which indicated the crucial r... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:1ec1ece3469e9d3346eecc5f","quotes":["Although each siRNA for KRAS , AKT , and ERK also inhibited cell growth in t... | [
"CLM:1ec1ece3469e9d3346eecc5f",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9507988"
] | [
"SPAN:7effe062527f6eb980141599"
] | [] | [] | {"qa_id":"QA:522cd869dc1b6b60fb6913c2","qa_group_id":"QAG:5098302aacb21575375251e3","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Although each siRNA for KRAS , AKT , and ERK also inhibited cell g... |
QA:526dcba504f796ad0840a099 | QAG:c9a03ac6b368945da62366f2 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "MIR143#12 potently suppressed cell growth in colorectal and pancreatic cancer cell lines via apoptosis induced by repression of the entire rat sarcoma virus (RAS) network, which was achieved by silencing KRAS , Son of sevenless homolog 1 ( SOS1 ) , AKT , and extracellu... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:fed25041b84a99bb18c50595","quotes":["MIR143#12 potently suppressed cell growth in colorectal and pancreatic cance... | [
"CLM:fed25041b84a99bb18c50595",
"CLM:02548fb255630e1212583b71"
] | [
"PMCID:PMC9507988"
] | [
"SPAN:dda10cc1a3258f1b1a18ba6a"
] | [] | [] | {"qa_id":"QA:526dcba504f796ad0840a099","qa_group_id":"QAG:c9a03ac6b368945da62366f2","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"MIR143#12 potently suppressed cell growth in colorectal and pancre... |
QA:53e605f8c962e722947c9b50 | QAG:ce03c4542d2d1de600af2276 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Cetuximab promoted RSL3-induced ferroptosis by inhibiting the Nrf2/HO-1 in KRAS mutant CRC cells, and this was further demonstrated in a xenograft nude mouse model"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance req... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b83bee8e22318c5c55dc0acf","quotes":["Cetuximab promoted RSL3-induced ferroptosis by inhibiting the Nrf2/HO-1 in K... | [
"CLM:b83bee8e22318c5c55dc0acf",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC8590697"
] | [
"SPAN:499c1c40d7a008d0de8e8995"
] | [] | [] | {"qa_id":"QA:53e605f8c962e722947c9b50","qa_group_id":"QAG:ce03c4542d2d1de600af2276","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Cetuximab promoted RSL3-induced ferroptosis by inhibiting the Nrf2... |
QA:54dc697eb20b72680a62564d | QAG:2c5a396607513e0055534d40 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "98 Normal ASF-4-1 human fibroblast >100 >20 >20 >20 TIG-3-20 human fibroblast >100 >20 >20 >20 KMST-6 human fibroblast >100 >20 >20 >20 H9C2 rat heart myoblast >100 >20 >20 >20 Figure 2 MIR143#12 replacement inhibited growth of colorectal and pancreatic cancer cells wi... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:c9d8940a9ac365d6ac3f7783","quotes":["Cell line (mutation) MIR143#12 siR-KRAS siR-AKT siR... | [
"CLM:c9d8940a9ac365d6ac3f7783",
"CLM:07f77a4f2d6038063b9e7451",
"CLM:e4939b3dfe4db64ed7650302"
] | [
"PMCID:PMC9507988",
"PMCID:PMC9808374"
] | [
"SPAN:5f4c1f851754fb19a7a8b8ca",
"SPAN:ccecf34a32503a55d19ccfbd"
] | [
"ASC2:458b0b815681b531389c67b2"
] | [
"HYP:DCH:7500f9b5556e1797d3c65bbc"
] | {"qa_id":"QA:54dc697eb20b72680a62564d","qa_group_id":"QAG:2c5a396607513e0055534d40","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"98 Normal ASF-4-1 human fibroblast >100 >20 >20 >20 TIG-3-20 human... |
QA:558d2b9a949ee2579e1de04d | QAG:3d0088d1371be86c3c92d0ac | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "2019 ) was associated with the depth of tumor invasion, differentiation, and tumor size in colorectal carcinoma ( Yu et al., 2016 ; Sun et al., 2017 ; Simons et al., 2018 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated prove... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:e99d46792c642fc4e3b1de36","quotes":["For example, the expression level of the antiaging gene Sirtuin 1 ( Bosch-Pr... | [
"CLM:e99d46792c642fc4e3b1de36",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8696016"
] | [
"SPAN:5778af476451dedff954fd1a"
] | [] | [] | {"qa_id":"QA:558d2b9a949ee2579e1de04d","qa_group_id":"QAG:3d0088d1371be86c3c92d0ac","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"2019 ) was associated with the depth of tumor invasion, differenti... |
QA:55b0dacc5030adc8ab2e488d | QAG:0f6e4906d2678a4de0491b1b | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Conclusions In this phase 3 trial of a KRAS G12C inhibitor plus an EGFR inhibitor in patients with chemorefractory metastatic colorectal cancer, both doses of sotorasib in combination with panitumumab led to longer progression-free survival than standard treatment"? Re... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:60cd0128ecb2baee335356c9","quotes":["Conclusions In this phase 3 trial of a KRAS G12C in... | [
"CLM:60cd0128ecb2baee335356c9",
"CLM:3cd4082a1fbc3057f3124cf1",
"CLM:80376b4edb77787d4a5f5dac"
] | [
"PMID:37870968",
"PMCID:PMC9808374"
] | [
"SPAN:42b9db74ce87fa931f8ae655",
"SPAN:d77dd331465f38eb94409a73"
] | [
"ASC2:4394f9a6442e6068caff9c39"
] | [
"HYP:DCH:39650f7ab6bc83985af8868e"
] | {"qa_id":"QA:55b0dacc5030adc8ab2e488d","qa_group_id":"QAG:0f6e4906d2678a4de0491b1b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Conclusions In this phase 3 trial of a KRAS G12C inhibitor plus an... |
QA:57e4f4d68f0548faa620c7fb | QAG:8045abddde0af45993abe83f | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Occupational physical activity measures was not associated with risk of rectal cancer in men, and stratification on subgroups did not lead to clear associations (Tables 5 , 6 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated p... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:68d81379b1fedbffb4bbbf70","quotes":["Occupational physical activity measures were not associated with risk of rec... | [
"CLM:68d81379b1fedbffb4bbbf70",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9470639"
] | [
"SPAN:d9ee0659ecbfc8cb7c857367"
] | [] | [] | {"qa_id":"QA:57e4f4d68f0548faa620c7fb","qa_group_id":"QAG:8045abddde0af45993abe83f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Occupational physical activity measures was not associated with ri... |
QA:58073a9d93dc9a658d82fe2e | QAG:5db3f3f93f2241a0ff31d4ad | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Rate of HLA LOH was also slightly increased in KRAS G12D mutated CRC (18%) compared to KRAS -WT CRC (15%, p = 0.008)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4cf10bed8b155284d3ce8f74","quotes":["Rate of HLA LOH was also slightly elevated in KRAS ... | [
"CLM:4cf10bed8b155284d3ce8f74",
"CLM:1cba67a12cdd2f006af7d9e3",
"CLM:24bf1ea734beab4b59839818"
] | [
"PMCID:PMC9734185",
"PMCID:PMC9270407"
] | [
"SPAN:1f713155c4e12461e282529c",
"SPAN:4217b67375f435f392910688"
] | [
"ASC2:75386d381a13e8e3c1c2014f"
] | [
"HYP:DCH:dac15af63bd905dd088fb2a9"
] | {"qa_id":"QA:58073a9d93dc9a658d82fe2e","qa_group_id":"QAG:5db3f3f93f2241a0ff31d4ad","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Rate of HLA LOH was also slightly increased in KRAS G12D mutated C... |
QA:5947a71c537f04d80cc4f83f | QAG:fb6017ad261d5001b9e28172 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Some preclinical data have suggested that G12C mutated colorectal cancer lines have metabolic characteristics that lead to evasion of apoptosis rather than increased growth rate ( 22 )"? Return the original wording with paper, Claim, and Evidence Span references.
Inte... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b965ada98db7938104c5be60","quotes":["Some preclinical data have suggested that G12C mutated colorectal cancer lin... | [
"CLM:b965ada98db7938104c5be60",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC8514824"
] | [
"SPAN:7bca4af20c43579b8b7a1efa"
] | [] | [] | {"qa_id":"QA:5947a71c537f04d80cc4f83f","qa_group_id":"QAG:fb6017ad261d5001b9e28172","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Some preclinical data have suggested that G12C mutated colorectal ... |
QA:5a609f2b49003be5418e133d | QAG:9eb22f87e91b91c95933c11e | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In men, BMI and clothing-size was associated with risk of colon, but not rectal cancer, regardless of molecular features subgroups"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact suppo... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:ca66e4c11ee307bb35fe22d1","quotes":["In men, BMI and clothing-size were positively associated with risk of colon,... | [
"CLM:ca66e4c11ee307bb35fe22d1",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9470639"
] | [
"SPAN:10cb51e35bc925a17bf04d8b"
] | [] | [] | {"qa_id":"QA:5a609f2b49003be5418e133d","qa_group_id":"QAG:9eb22f87e91b91c95933c11e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In men, BMI and clothing-size was associated with risk of colon, b... |
QA:5dd99cff5e2425c44d88813a | QAG:dd096178b12a23c8a3c4f02c | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "These results demonstrate that elevated tumoral CKB mRNA and protein expression levels predicts increased responsiveness to SLC6A8 inhibition by RGX-202, consistent with CKB being an upstream component of the CKB/SLC6A8 phosphocreatine metabolic axis in CRC and a gene ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:63a6c5eaa7b46d05a1411aa3","quotes":["These results demonstrate that elevated tumoral CKB mRNA and protein express... | [
"CLM:63a6c5eaa7b46d05a1411aa3",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:29a5bb53e4b0c68fc75d9fa7"
] | [] | [] | {"qa_id":"QA:5dd99cff5e2425c44d88813a","qa_group_id":"QAG:dd096178b12a23c8a3c4f02c","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"These results demonstrate that elevated tumoral CKB mRNA and prote... |
QA:5e22ada6804016a10719650e | QAG:525729cbc3e5fd1defa151ba | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "The importance of Bcl-xL as a mediator of acute resistance to KRAS G12C inhibitors was shown in vivo , where combined treatment of KRAS G12C MT colorectal cancer xenografts with the BCL-2/Bcl-xL and KRAS G12C inhibitors, navitoclax and AZ’8037 led to supraadditive redu... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a5a8007f8bc33bf22d8f1cdb","quotes":["The importance of Bcl-xL as a mediator of acute resistance to KRAS G12C inhi... | [
"CLM:a5a8007f8bc33bf22d8f1cdb",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:80cad1cec84fcb609a128490"
] | [] | [] | {"qa_id":"QA:5e22ada6804016a10719650e","qa_group_id":"QAG:525729cbc3e5fd1defa151ba","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"The importance of Bcl-xL as a mediator of acute resistance to KRAS... |
QA:5fc983ad98dbf51479d283c6 | QAG:84d27dd39413de4d1ab2b18b | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "This effect suggests that PD inhibited PI3K/Akt independent of EGF/EGFR to a certain degree"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Ev... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5eb2a07e67762fd2ab503237","quotes":["This effect suggests that PD inhibited PI3K/Akt independent of EGF/EGFR to a... | [
"CLM:5eb2a07e67762fd2ab503237",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9646952"
] | [
"SPAN:0711156c5bcc015548e681f4",
"SPAN:785760352ad89af3ed582390"
] | [] | [] | {"qa_id":"QA:5fc983ad98dbf51479d283c6","qa_group_id":"QAG:84d27dd39413de4d1ab2b18b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"This effect suggests that PD inhibited PI3K/Akt independent of EGF... |
QA:602ada7a999ac9860bfcd947 | QAG:ba008a5dbe59c0e10b825bf3 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "We treated murine KRAS wild-type MC38 CRC tumors with RGX-202-01 after volumes achieved ~150 mm 3 and observed substantially inhibited tumor growth in this immunocompetent model ( Fig. 3B )"? Return the original wording with paper, Claim, and Evidence Span references.
... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:dd890ac98cc1397d1ee2cc39","quotes":["We treated murine KRAS wild-type MC38 CRC tumors with RGX-202-01 after volum... | [
"CLM:dd890ac98cc1397d1ee2cc39",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:26b68b71ec41e1a128047493"
] | [] | [] | {"qa_id":"QA:602ada7a999ac9860bfcd947","qa_group_id":"QAG:ba008a5dbe59c0e10b825bf3","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"We treated murine KRAS wild-type MC38 CRC tumors with RGX-202-01 a... |
QA:627df497267edb652ca28b8d | QAG:81cf4fc4bb88a8967e29b058 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Oncogenic KRAS G12C mutations occur in ~4% of patients with CRC, and was associated with poor prognosis 3 – 7"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with pa... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:9d78d0e70cd47467145e3b23","quotes":["Oncogenic KRAS G12C mutations occur in ~4% of patients with CRC, and are ass... | [
"CLM:9d78d0e70cd47467145e3b23",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC10803265"
] | [
"SPAN:1474f18e50acfe3d6c3d6831"
] | [] | [] | {"qa_id":"QA:627df497267edb652ca28b8d","qa_group_id":"QAG:81cf4fc4bb88a8967e29b058","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Oncogenic KRAS G12C mutations occur in ~4% of patients with CRC, a... |
QA:62de1d977ba7da2057f3aa01 | QAG:7bae4e73f6d3e760c9ff830b | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "MIR143#12 potently suppressed cell growth in colorectal and pancreatic cancer cell lines via apoptosis promoted by repression of the entire rat sarcoma virus (RAS) network, which was achieved by silencing KRAS , Son of sevenless homolog 1 ( SOS1 ) , AKT , and extracell... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:5e24bd205329454cf9b2b92e","quotes":["MIR143#12 potently suppressed cell growth in colore... | [
"CLM:5e24bd205329454cf9b2b92e",
"CLM:02548fb255630e1212583b71",
"CLM:b65b17d98021fb586c5c3450"
] | [
"PMCID:PMC9507988",
"PMCID:PMC8934478"
] | [
"SPAN:dda10cc1a3258f1b1a18ba6a",
"SPAN:7fb2c7975ffc327940359fa5"
] | [
"ASC2:72d43f9272b2c85f8d87cef5"
] | [
"HYP:DCH:c1476991a3b07e9cffec211b"
] | {"qa_id":"QA:62de1d977ba7da2057f3aa01","qa_group_id":"QAG:7bae4e73f6d3e760c9ff830b","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"MIR143#12 potently suppressed cell growth in colorectal and pancre... |
QA:64256ab02a7502e6b425fd53 | QAG:91ababcda62acde319dc33d8 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "A, KRAS G12C MT colorectal cancer cells received increasing concentrations of AZ’1569 for 120 hours and cell viability determined using CTG assay"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:df668de2dd24176b77aa44b6","quotes":["A, KRAS G12C MT colorectal cancer cells were treated with increasing concent... | [
"CLM:df668de2dd24176b77aa44b6",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:a719c3455e75fbb9458ce288"
] | [] | [] | {"qa_id":"QA:64256ab02a7502e6b425fd53","qa_group_id":"QAG:91ababcda62acde319dc33d8","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"A, KRAS G12C MT colorectal cancer cells received increasing concen... |
QA:69d2207fa878fd3639bfe26a | QAG:3c79520b3a2790a569e21a8e | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "KRAS mutations was associated with poor prognosis in metastatic CRC patients 14"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:12aca7b09ecf60ddbebf2590","quotes":["KRAS mutations were associated with poor prognosis in metastatic CRC patient... | [
"CLM:12aca7b09ecf60ddbebf2590",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC10721872"
] | [
"SPAN:66adc4d20191ec0074b98aaf"
] | [] | [] | {"qa_id":"QA:69d2207fa878fd3639bfe26a","qa_group_id":"QAG:3c79520b3a2790a569e21a8e","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"KRAS mutations was associated with poor prognosis in metastatic CR... |
QA:6d85b9d9ab89abbc46a31556 | QAG:6e8edb56d062fbd7965e3d95 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "H Tissue microarray cohort ( n = 137) showed that PCSK9 protein expression predicted poor survival of APC MUT KRAS MUT CRC ( n = 66), but not in APC MUT KRAS WT CRC ( n = 71) or overall cohort"? Return the original wording with paper, Claim, and Evidence Span reference... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a10525bf5a02ad79e48fccda","quotes":["H Tissue microarray cohort ( n = 137) showed that PCSK9 protein expression p... | [
"CLM:a10525bf5a02ad79e48fccda",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:ab63ae20311300fccca2c20d"
] | [] | [] | {"qa_id":"QA:6d85b9d9ab89abbc46a31556","qa_group_id":"QAG:6e8edb56d062fbd7965e3d95","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"H Tissue microarray cohort ( n = 137) showed that PCSK9 protein ex... |
QA:6e38e942b1881dabecf59a49 | QAG:d7c0aa8f8eb844c8d9e542ec | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In our study, we found that combination treatment did not significantly affect the mRNA expressions of elF5A, NEDD4, PEAK, SMURF2, UBCH5 (Additional file 1 : Figure S1A to S1J), but significant increased β-TrCP mRNA level (Fig. 4 A and B) and protein level (Fig. 4 C) i... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:b65b17d98021fb586c5c3450","quotes":["In our study, we found that combination treatment did not significantly affe... | [
"CLM:b65b17d98021fb586c5c3450"
] | [
"PMCID:PMC8934478"
] | [
"SPAN:7fb2c7975ffc327940359fa5"
] | [] | [] | {"qa_id":"QA:6e38e942b1881dabecf59a49","qa_group_id":"QAG:d7c0aa8f8eb844c8d9e542ec","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In our study, we found that combination treatment did not signific... |
QA:6f4eda2a6f289841806b062d | QAG:f443d11575f16f0fda6a1989 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "1 RYR2 expression was associated with CRC metastasis behavior"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Evidence Span references; assess... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4825da29d20cff1aad89d2f0","quotes":["Fig. 1 RYR2 expression was associated with CRC metastasis behavior."],"citat... | [
"CLM:4825da29d20cff1aad89d2f0",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC10061290"
] | [
"SPAN:1bfcbaa604aa32211b1176f5"
] | [] | [] | {"qa_id":"QA:6f4eda2a6f289841806b062d","qa_group_id":"QAG:f443d11575f16f0fda6a1989","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"1 RYR2 expression was associated with CRC metastasis behavior\"? R... |
QA:703f7564b3494a914fcf52d5 | QAG:53a59857b60efdb93855568f | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "The mCRC tissues showed increased RyR2 expression compared with the primary CRC tissues"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passage with paper, Claim, and Eviden... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:02548fb255630e1212583b71","quotes":["The mCRC tissues showed elevated RyR2 expression compared with the primary C... | [
"CLM:02548fb255630e1212583b71",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC10061290"
] | [
"SPAN:c89ebfa2c5b0bd328f4ea548"
] | [] | [] | {"qa_id":"QA:703f7564b3494a914fcf52d5","qa_group_id":"QAG:53a59857b60efdb93855568f","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"The mCRC tissues showed increased RyR2 expression compared with th... |
QA:761059a77091870c37874a16 | QAG:1772ed51ae5a63d332ce70ff | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "And then combination treatment inhibits CRC growth by suppressing PI3K/Akt/mTOR pathway The development of CRC was associated with the abnormal function of cellular transmembrane signaling systems"? Return the original wording with paper, Claim, and Evidence Span refer... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:0d2c456856b58d1e9a490030","quotes":["And then combination treatment inhibits CRC growth by suppressing PI3K/Akt/m... | [
"CLM:0d2c456856b58d1e9a490030",
"CLM:55e0765cb3287e53f9c24e73"
] | [
"PMCID:PMC8934478"
] | [
"SPAN:415d0677629aab3421092ec1"
] | [] | [] | {"qa_id":"QA:761059a77091870c37874a16","qa_group_id":"QAG:1772ed51ae5a63d332ce70ff","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"And then combination treatment inhibits CRC growth by suppressing ... |
QA:76d54dbacc7ab1ffbc100a25 | QAG:a974533669a4b109c5124427 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In our study, we found that combination treatment did not improve the mRNA expressions of elF5A, NEDD4, PEAK, SMURF2, UBCH5 (Additional file 1 : Figure S1A to S1J), but significant increased β-TrCP mRNA level (Fig. 4 A and B) and protein level (Fig. 4 C) in the CRC cel... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:c3f6029b1ebea4a861adf1d9","quotes":["In our study, we found that combination treatment did not significantly affe... | [
"CLM:c3f6029b1ebea4a861adf1d9"
] | [
"PMCID:PMC8934478"
] | [
"SPAN:7fb2c7975ffc327940359fa5"
] | [] | [] | {"qa_id":"QA:76d54dbacc7ab1ffbc100a25","qa_group_id":"QAG:a974533669a4b109c5124427","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In our study, we found that combination treatment did not improve ... |
QA:76dc316437d10a0e439949ef | QAG:e844af6b336d664e193c136a | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "To investigate whether platycodin-D can sensitize KRAS -mutant colorectal cancer cells to cetuximab by inhibiting the PI3K/Akt signaling pathway, HCT116 and LoVo cells received cetuximab and platycodin-D. LY294002 and SC79 were used to regulate Akt to further evaluate ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:d7f0ffba35977167f5288623","quotes":["To investigate whether platycodin-D can sensitize K... | [
"CLM:d7f0ffba35977167f5288623",
"CLM:1cba67a12cdd2f006af7d9e3",
"CLM:178d3dfe9b9beb6ba395173e"
] | [
"PMCID:PMC9646952",
"PMCID:PMC8590697"
] | [
"SPAN:aabbc66b10a0ee587d0910b4",
"SPAN:cc8eb6cee7de699adf6a5aa9"
] | [
"ASC2:499803b3ff48f18d09761acc"
] | [] | {"qa_id":"QA:76dc316437d10a0e439949ef","qa_group_id":"QAG:e844af6b336d664e193c136a","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"To investigate whether platycodin-D can sensitize KRAS -mutant col... |
QA:77b58f0b5a3b967f692e6037 | QAG:71fb980b36d9edc0285807f7 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Results In men, BMI and clothing-size was associated with risk of colon, but not rectal cancer, regardless of molecular features subgroups; the strongest associations were observed for PIK3CA mut colon cancer"? Return the original wording with paper, Claim, and Evidenc... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:f4147fdc904531af64827e3d","quotes":["Results In men, BMI and clothing-size were positively associated with risk o... | [
"CLM:f4147fdc904531af64827e3d",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9470639"
] | [
"SPAN:5d038e95a8ae83873379c12a"
] | [] | [] | {"qa_id":"QA:77b58f0b5a3b967f692e6037","qa_group_id":"QAG:71fb980b36d9edc0285807f7","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Results In men, BMI and clothing-size was associated with risk of ... |
QA:78153f82444d3e866e314da7 | QAG:fd8b137d57c9431d40e5e7e5 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Treatment with AZ’1569 led to acute increases in the proapoptotic protein BIM, which may “prime” cells for death, but was insufficient to cause apoptosis in five of seven KRAS G12C MT colorectal cancer models due to the presence of inhibitory antiapoptotic proteins, su... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:4fd6da25d5152cf6f190f468","quotes":["Treatment with AZ’1569 resulted in acute increases in the proapoptotic prote... | [
"CLM:4fd6da25d5152cf6f190f468",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:647c11856383175370e4e81a"
] | [] | [] | {"qa_id":"QA:78153f82444d3e866e314da7","qa_group_id":"QAG:fd8b137d57c9431d40e5e7e5","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Treatment with AZ’1569 led to acute increases in the proapoptotic ... |
QA:78283672fb6bc90b0ea3ebb4 | QAG:892937b041251002579b7683 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In addition, patients with NSCLC were required to have received prior platinum-containing chemotherapy, and an anti-programmed death/programmed death-ligand 1 (PD1/PDL1) antibody, and patients with CRC were required to have previously received at least 2 prior lines of... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:61fcf4402cba2902a8a4d7ce","quotes":["Patients were also required to have evaluable or measurable disease accordin... | [
"CLM:61fcf4402cba2902a8a4d7ce",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC9255981"
] | [
"SPAN:82af22e452fed4997190df8b"
] | [] | [] | {"qa_id":"QA:78283672fb6bc90b0ea3ebb4","qa_group_id":"QAG:892937b041251002579b7683","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In addition, patients with NSCLC were required to have received pr... |
QA:78c1dbec41a9fc1db2c29dec | QAG:7231bebac04acee9f9ad70e3 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Depletion of CKB in CRC cells led to 83% inhibition of liver metastasis, comparable to the effects mediated by RGX-202 (86%) (fig. S1, D and E)"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return th... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:a2f963330d147089597381e9","quotes":["Depletion of CKB in CRC cells resulted in 83% inhibition of liver metastasis... | [
"CLM:a2f963330d147089597381e9",
"CLM:125bd56675f6596398baa1a9"
] | [
"PMCID:PMC8494442"
] | [
"SPAN:0a8bc0bd69ccb7c4da7e9051"
] | [] | [] | {"qa_id":"QA:78c1dbec41a9fc1db2c29dec","qa_group_id":"QAG:7231bebac04acee9f9ad70e3","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Depletion of CKB in CRC cells led to 83% inhibition of liver metas... |
QA:795c1a1ca6b32716906b5bcf | QAG:1df2a960da68dfed80d5da38 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "The KRAS G12C mutation was associated with worse overall survival in patients with CRC and is readily identified through standard-of-care testing, thus highlighting an area of need for more effective and targeted therapeutic approaches 4"? Return the original wording w... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification","cross_paper_provenance"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:3807b7073be9625f65803816","quotes":["The KRAS G12C mutation is associated with worse ove... | [
"CLM:3807b7073be9625f65803816",
"CLM:1cba67a12cdd2f006af7d9e3",
"CLM:60cd0128ecb2baee335356c9"
] | [
"PMCID:PMC10803265",
"PMID:37870968"
] | [
"SPAN:1fcfd2bea6362815658b00af",
"SPAN:42b9db74ce87fa931f8ae655"
] | [
"ASC2:eed455081d47c4ba9eb67efb"
] | [
"HYP:DCH:03e0842b7da6bd4fcc62c56e"
] | {"qa_id":"QA:795c1a1ca6b32716906b5bcf","qa_group_id":"QAG:1df2a960da68dfed80d5da38","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"The KRAS G12C mutation was associated with worse overall survival ... |
QA:79f13a4bf5d2bb5e558e8752 | QAG:7d012a9f8b2e441b59d6a187 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "KRASG12C MT colorectal cancer cell lines received 1 μmol/L AZ’1569 for the indicated times and protein lysates were used for WB analysis for the KRAS downstream effectors"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provena... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:dcfa31366355ce9b6c32913a","quotes":["KRASG12C MT colorectal cancer cell lines were treated with 1 μmol/L AZ’1569 ... | [
"CLM:dcfa31366355ce9b6c32913a",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9808374"
] | [
"SPAN:d383a1ec9e536398627a1996"
] | [] | [] | {"qa_id":"QA:79f13a4bf5d2bb5e558e8752","qa_group_id":"QAG:7d012a9f8b2e441b59d6a187","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"KRASG12C MT colorectal cancer cell lines received 1 μmol/L AZ’1569... |
QA:7a9649af4ce9d646bc3b88a0 | QAG:68b55db6f098e2684b6e1dc9 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "The combination of PLK1 and MEK inhibitors synergistically inhibited CRC cell proliferation and induced apoptosis in vitro and in vivo"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact s... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:10c602685c3061c03aa0656e","quotes":["The combination of PLK1 and MEK inhibitors synergistically inhibited CRC cel... | [
"CLM:10c602685c3061c03aa0656e",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC8732282"
] | [
"SPAN:f50b057d62795560ed3ee1c0"
] | [] | [] | {"qa_id":"QA:7a9649af4ce9d646bc3b88a0","qa_group_id":"QAG:68b55db6f098e2684b6e1dc9","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"The combination of PLK1 and MEK inhibitors synergistically inhibit... |
QA:7b883be294d92d6240ce80cd | QAG:2710bc8307892c3910f6de88 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "K20 model predicted that most of the colorectal cancer patients with KRAS mutation are KRAS-sensitive with some exceptions and the model prediction scores are associated with several TCGA expression subtypes"? Return the original wording with paper, Claim, and Evidence... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:eab184c853fdab0f69af50e2","quotes":["K20 model predicts that most of the colorectal cancer patients with KRAS mut... | [
"CLM:eab184c853fdab0f69af50e2",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC10187917"
] | [
"SPAN:d3fc7fe06f1e88273a951acf"
] | [] | [] | {"qa_id":"QA:7b883be294d92d6240ce80cd","qa_group_id":"QAG:2710bc8307892c3910f6de88","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"K20 model predicted that most of the colorectal cancer patients wi... |
QA:7c1ef20df75a73a6b93f36e2 | QAG:bea3afadeb39ba868e3de5fc | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "H R-IMPP and PF-0644846 inhibited p-ERK and expression of its downstream target Cyclin D3 in APC / KRAS -mutant CRC cell lines"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supportin... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:af1513047edf26d2a8715e23","quotes":["H R-IMPP and PF-0644846 inhibited p-ERK and expression of its downstream tar... | [
"CLM:af1513047edf26d2a8715e23",
"CLM:1cba67a12cdd2f006af7d9e3"
] | [
"PMCID:PMC9270407"
] | [
"SPAN:234fd822bbf02d2e3d739306"
] | [] | [] | {"qa_id":"QA:7c1ef20df75a73a6b93f36e2","qa_group_id":"QAG:bea3afadeb39ba868e3de5fc","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"H R-IMPP and PF-0644846 inhibited p-ERK and expression of its down... |
QA:7c7c7ba2c640907721783695 | QAG:2440987184fed2262bdf9868 | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "Significantly, we for the first time demonstrated that cetuximab can promote RSL3 promoted ferroptosis by markedly suppressing Nrf2/HO-1 signalling via p38 MAPK activation in KRAS mutant CRC cell lines"? Return the original wording with paper, Claim, and Evidence Span ... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:c03be9e8c67ddb6aefbbde05","quotes":["Significantly, we for the first time demonstrated that cetuximab can promote... | [
"CLM:c03be9e8c67ddb6aefbbde05",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC8590697"
] | [
"SPAN:870913b22365becef9927dce"
] | [] | [] | {"qa_id":"QA:7c7c7ba2c640907721783695","qa_group_id":"QAG:2440987184fed2262bdf9868","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"Significantly, we for the first time demonstrated that cetuximab c... |
QA:7ea61092b233d2f4923b0e32 | QAG:78d5510f934357a47b1bbc2c | provenance_qa | exact_evidence_retrieval | provenance_qa | G009 | en | train | Which exact source passage supports the statement "In addition, inhibition of GSK-3β decreased CRC tumor cell growth in vitro and in vivo ( Shakoori et al., 2005 , 2007 )"? Return the original wording with paper, Claim, and Evidence Span references.
Integrated provenance requirements: return the exact supporting passa... | {"answer_type":"integrated_provenance","embedded_answer_types":["exact_evidence_retrieval","claim_evidence_verification"],"exact_evidence_retrieval":{"answer_type":"exact_evidence_retrieval","claim_id":"CLM:03cfb269a9159ad24fb4ab8b","quotes":["In addition, inhibition of GSK-3β decreased CRC tumor cell growth in vitro a... | [
"CLM:03cfb269a9159ad24fb4ab8b",
"CLM:3cd4082a1fbc3057f3124cf1"
] | [
"PMCID:PMC8696016"
] | [
"SPAN:9a46735baa86c51dc56108cb"
] | [] | [] | {"qa_id":"QA:7ea61092b233d2f4923b0e32","qa_group_id":"QAG:78d5510f934357a47b1bbc2c","qa_family":"provenance_qa","subtask_type":"exact_evidence_retrieval","language":"en","cluster_id":"G009","question":"Which exact source passage supports the statement \"In addition, inhibition of GSK-3β decreased CRC tumor cell growth ... |
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