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Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.
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All three patients (and possibly a fourth) who developed AML were postmenopausal, received continuous chlorambucil for greater than or equal to 4 years, had acute red cell anemia at the time of treatment, and had a wbc count in the range of 2700-7700/mm3.
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Whole blood histamine release studies were negative.
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Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.
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RESULTS: Two patients were obese and developed extensive abdominal wall skin necrosis.
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PLD also has a different cutaneous side effect profile than doxorubicin, and its cutaneous toxicity can be dose limiting.
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The major problems affecting compliance with pharmacotherapy for schizophrenia are outlined here showing, by means of case histories, how sertindole has benefited schizophrenic patients.
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Transient visual anomalies associated with drug treatment for spastic colon.
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No oligodendroglias with intranuclear inclusions were found.
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This article reviews current human and veterinary literature regarding the microbiology, pathogenesis, and treatment of nocardiosis and reports on the successful treatment of systemic nocardiosis in two dogs.
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Withdrawal emergent syndrome (WES) is a subtype of tardive dyskinesia that has been reported in children who were taken off antipsychotic therapy.
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We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids.
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In conclusion, intradermal skin tests can be a useful tool for detecting a potential cross-reaction between platinum salts.
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Beriberi is the systemic counterpart of thiamine deficiency and often manifests in cardiovascular collapse.
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HRCT obtained on inspiration showed dilated thick-walled bronchioli, and innumerable centrilobular linear and branching structures in the bilateral middle and lower lobes.
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One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).
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To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.
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Average length of stay postCDT was 7 days with no perioperative complications.
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Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.
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We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated ...
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She developed congestive heart failure, and hemodialysis was initiated.
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Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures.
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Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
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Both were alcoholic, malnourished and presented with radiologically widespread, smear-positive disease and lymphocytopenia.
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The global spreading of chloroquine-resistant falciparum malaria brings about an increasing use of quinine.
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In contrast, after the last course of chemotherapy, which did not include M-CSF, urinary protein excretion was not enhanced.
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We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.
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Experience with the use of cytotoxic drugs in the first trimester of pregnancy is limited.
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The patient died suddenly, and the autopsy revealed pulmonary embolism originating from the deep vein thrombosis caused by the compression of common iliac vein by the tumor.
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In early-recognized, subacute cases a surgical intervention using patches can be lifesaving.
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Naratriptan was extremely well tolerated, with no cardiovascular adverse events reported or observed.
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Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.
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Serial radiographic observation over two months.
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Safety and efficacy of S-1 chemotherapy in recurrent/metastatic head and neck cancer.
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On this regime, together with supportive psychotherapy, she experienced a sense of emotional well-being, exhibited a good level of functioning and maintained a safe body weight.
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Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.
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A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.
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She was subsequently admitted to hospital and was diagnosed as having nephrotic syndrome.
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We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.
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However, the patient became steroid-dependent and experienced recurrent optic neuritis during multiple attempts at tapering the steroids.
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A platelet autoantibody could not be detected by a radioactive platelet antiglobulin test, but autologous platelet survival data indicated a compensated thrombolytic state in the recovery period.
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We describe a Caucasian child who initially presented with clinical and histopathologic features consistent with inflammatory bowel disease, for whom additional investigations led to the diagnosis of severe chronic active Epstein-Barr virus infection.
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These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.
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Despite the widespread use of beta-sympathomimetic agents for preterm labour there appears to be a limited appreciation of the need for cardiovascular monitoring in the mother.
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Four weeks later, a coronary arteriogram showed only minimal luminal irregularities at the original site of occlusion, where significant reduction in diameter could be induced by ergonovine maleate.
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The patient was admitted to the emergency department of a local hospital within two days due to ongoing headache, elevated temperature, and nuchal rigidity, symptoms suggestive of meningitis.
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The diagnosis was made on the basis of inflammatory changes in the cerebral spinal fluid and localization of the abscess by means of computer and magnetic resonance tomography.
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Combined thrombolytic therapy for prosthetic mitral valve thrombosis.
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The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.
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CONCLUSION: This side effect, apparently unique to bupropion among antidepressants, may be mediated through dopaminergic effects in the basal ganglia.
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Atypical antipsychotics have reduced liability for inducing tardive dystonia and show antidystonic properties in patients with pre-existing tardive dystonia.
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A difference in chemical structure between these two drugs, particularly of a sulfur moiety, may help explain why the drug-induced disease did not recur.
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Nonopioid analgesics did not relieve her pain, and she was unable to walk without the aid of a walker.
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Posttransplant lymphoproliferative disorder of the nasopharynx.
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There is no known effective therapy for PEComa, and the molecular pathophysiology of aberrant mTOR signaling provided us with a scientific rationale to target this pathway therapeutically.
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Possible explanations of this ocular effect are offered: pharmacokinetic interference on the drugs used in glaucoma treatment, in vivo action on the muscarinic receptor, indirect effect via dopaminergic receptors, or direct effect on the ocular sympathetic postganglionic neurones.
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Both patients completely recovered after transient pancytopenia, but showed severe and intermediate neutropenia (0.216 and 0.768 x 10(9)/l, respectively) at the nadirs of aplastic crises.
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Twenty-one days of magnesium sulfate tocolysis were performed on a 28-year-old woman because of preterm labor at 31 weeks gestation.
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Cardiac function and symptoms recovered completely.
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Glucocorticoids in early rheumatoid arthritis.
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It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.
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Direct immunofluorescence revealed staining at the dermal-epidermal junction and around blood vessels with IgG in the first case and with IgG, IgA, and fibrin in the second case.
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Graft-versus-host disease was seen only in 41% of the bone marrow recipients.
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A physical and/or chemical in vitro compatibility of 5-FU and calcium folinic acid, without validated clinical data is not sufficient to use this mixture in routine clinical practice.
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CLINICAL FEATURES: The patient was a 22-yr-old obese man with metastatic testicular carcinoma who underwent a left-sided thoracoabdominal retroperitoneal tumour resection.
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Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.
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CASE: We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor.
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The symptoms started when the immune status reached normal CD4 T cell levels, in response to antiviral tritherapy.
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Imaging confirmed this excellent response.
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A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.
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Chemotherapy was stopped and systemic application of prednisolone was initiated.
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Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases.
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In each case, brief periods (5 to 20 seconds) of rapid atrial pacing were effective in terminating the supraventricular tachycardia and resulted in a return to normal sinus rhythm.
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This encouraging result suggests that BMT from an unrelated donor should be considered for ATL even if the disease is refractory to chemotherapy.
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Clinicians are advised to observe for symptoms of toxicity and to do serial blood levels to monitor this interaction.
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This is known as a PSA "bounce" or "bump." Some patients experience a second transient rise in PSA levels after irradiation.
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She rapidly developed profound CNS depression with stupor, hypothermia, hypoventilation and bradycardia.
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On her next anticoagulation clinic visit, the patient's INR had increased, although the dosage of warfarin had been reduced when the tolterodine had been prescribed.
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We conclude that autoimmune hemolytic anemia may be an unusual presentation for postirradiation sarcoma.
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A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.
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Rapid cycling in manic-depressives induced by tricyclic antidepressants.
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A bone marrow aspiration test on day 16 showed a markedly increased number of activated macrophages showing massive hemophagocytosis.
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Little is known about the behaviour of endogenous thrombopoietin (TPO) serum levels during rapid sequences of dose-intensified chemotherapy.
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CASE SUMMARY: A 50-year-old white woman with a history of advanced breast cancer refractory to other treatment modalities was receiving vinorelbine.
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Infected graft transplantation is an unwelcome complication that may lead to serious consequences in the immunosuppressed host.
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MH was treated immediately with dantrolene; the patient recovered within 14 days.
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He was discharged on March 15; myoclonic muscle spasms began that afternoon.
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The case suggests that mechanical valve replacement may not prevent gastrointestinal bleeding in Heyde syndrome and that octreotide treatment should be considered in these cases.
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The diagnosis can be accurately made with axial computed tomography (CT) of the involved spinal segment.
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The clinical features and management of this combined intoxication are discussed.
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Treatment with topical antibiotic agents did not improve the symptoms.
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This is the first report of successful utilization of the prepuce as a skin graft to reconstruct a full thickness skin necrosis due to a phenobarbital extravasation to the forefoot of a newborn.
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Pseudomonas corneal ulcer after use of extended-wear rigid gas-permeable contact lens.
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The skin lesions were eczematoid patches, flaccid bullae and crusted plaques on the trunk and extremities, histologically showing a high epidermal blister with acantholysis.
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We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.
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However, the electroretinogram was abnormal on several occasions during therapy with rifabutin, but returned to normal 3 months after withdrawal of the medication.
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We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.
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CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.
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Photosensitive reflex epilepsy is provoked by environmental flicker stimuli.
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Objective causality assessment revealed that the adverse event was probably drug induced.
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