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renal papillary necrosis | Does paracetamol cause urothelial cancer or renal papillary necrosis? | Kidney Papillary Necrosis | Kidney Papillary Necrosis Renal Medullary Necrotizing Papillitides Papillitis | A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAIL... | MESH:D007681 |
renal papillary necrosis | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | Kidney Papillary Necrosis | Kidney Papillary Necrosis Renal Medullary Necrotizing Papillitides Papillitis | A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAIL... | MESH:D007681 |
cancer of the renal pelvis | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | Kidney Neoplasms | Cancer of Kidney the Renal Cancers Neoplasm Neoplasms | Tumors or cancers of the KIDNEY.
| MESH:D007680 |
phenacetin | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | Phenacetin | Acetophenetidin Phenacetin | A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)
| MESH:D010615 |
paracetamol | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | Acetaminophen | APAP Acamol Acephen Acetaco Acetamidophenol Acetaminophen Acetominophen Algotropyl Anacin 3 Anacin-3 Anacin3 Datril Hydroxyacetanilide N-(4-Hydroxyphenyl)acetanilide N-Acetyl-p-aminophenol Panadol Paracetamol Tylenol p-Acetamidophenol p-Hydroxyacetanilide | Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
| MESH:D000082 |
ureteric cancer | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | Ureteral Neoplasms | Cancer of Ureter the Ureteral Cancers Neoplasm Neoplasms Of | Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.
| MESH:D014516 |
cancers | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | Neoplasms | Benign Neoplasm Neoplasms Cancer Cancers Neoplasia Tumor Tumors | New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| MESH:D009369 |
cancer of the ureter | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | Ureteral Neoplasms | Cancer of Ureter the Ureteral Cancers Neoplasm Neoplasms Of | Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.
| MESH:D014516 |
Dapsone | Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. | Dapsone | 4,4' Diaminophenyl Sulfone 4,4'-Diaminophenyl Avlosulfone DADPS Dapsoderm-X Dapson-Fatol Dapsone Diaminodiphenylsulfone Diaphenylsulfone Disulone Fatol Brand of Mex-America Orsade Sulfona Sulfonyldianiline | A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of m... | MESH:D003622 |
hemolytic anemia | Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. | Anemia, Hemolytic | Acquired Hemolytic Anemia Microangiopathic | A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
| MESH:D000743 |
leprosy | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Leprosy | Disease Hansen Hansen's Hansens Leprosies Leprosy | A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.
| MESH:D007918 |
hemolytic anemia | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Anemia, Hemolytic | Acquired Hemolytic Anemia Microangiopathic | A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
| MESH:D000743 |
dapsone | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Dapsone | 4,4' Diaminophenyl Sulfone 4,4'-Diaminophenyl Avlosulfone DADPS Dapsoderm-X Dapson-Fatol Dapsone Diaminodiphenylsulfone Diaphenylsulfone Disulone Fatol Brand of Mex-America Orsade Sulfona Sulfonyldianiline | A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of m... | MESH:D003622 |
hemolysis | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Hemolysis | Hemolysis | The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| MESH:D006461 |
glutathione | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Glutathione | Glutathione Reduced gamma L Glu L Cys Gly Glutamyl Cysteinylglycine gamma-L-Glu-L-Cys-Gly gamma-L-Glutamyl-L-Cysteinylglycine | A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
| MESH:D005978 |
GSH | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Glutathione | Glutathione Reduced gamma L Glu L Cys Gly Glutamyl Cysteinylglycine gamma-L-Glu-L-Cys-Gly gamma-L-Glutamyl-L-Cysteinylglycine | A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
| MESH:D005978 |
pentose phosphate | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Pentosephosphates | Pentosephosphates | MESH:D010428 | |
infection | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | Infection | Infection Infections | Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
| MESH:D007239 |
metoprolol | Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. | Metoprolol | AstraZeneca Brand of Metaoprolol Tartrate Seloken Beloc Duriles Beloc-Duriles BelocDuriles Betaloc Astra Betaloc-Astra BetalocAstra Betalok CGP 2175 CGP-2175 CGP2175 H 93 26 93-26 9326 Leiras Metoprolol Succinate or Metoprolol Lopressor Novartis Metprolol Spesicor Spesikor | A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
| MESH:D008790 |
propafenone | Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. | Propafenone | Abbott Brand of Propafenone Hydrochloride Aliud Alpharma Apo-Propafenone Apotex Arythmol Azupharma Baxarytmon Cuxafenon Fenoprain Hexal Juta Jutanorm Kendrick Knoll Merck dura Nistaken Norfenon Pintoform Prolecofen Propafenon AL Minden (R)-Isomer (S)-Isomer (+-)-Isomer Propamerck Q-Pharm Rythmol Rytmo-Puren Rytmogenat ... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
| MESH:D011405 |
diltiazem | Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. | Diltiazem | Aldizem Biovail Brand of Diltiazem Hydrochloride CRD 401 CRD-401 CRD401 Cardil Cardizem Dilacor XR Dilren Malate Dilzem Tiazac Watson Pharmaceuticals Diltazem | A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
| MESH:D004110 |
sparteine | Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. | Sparteine | Anhydrous Sparteine Sulfate D-sparteine Depasan Retard Genisteine Alkaloid L-Sparteine Pachycarpine (1:1) Pentahydrate (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer Hydrochloride (7R-(7alpha,7aalpha,14alpha,14abeta))-Isomer Hydroiodide Monohydrochloride Monohydroiodide (7S-(7alpha,7aalpha,14alpha,14aalpha))-Isomer (+)-I... | A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
| MESH:D013034 |
coronary artery disease | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Coronary Artery Disease | Arterioscleroses Coronary Arteriosclerosis Artery Disease Diseases Atheroscleroses Atherosclerosis | Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
| MESH:D003324 |
shock | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Shock | Circulatory Collapse Failure Hypovolemic Shock | A pathological condition manifested by failure to perfuse or oxygenate vital organs.
| MESH:D012769 |
AV block | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Atrioventricular Block | AV Block Blocks Atrioventricular Conduction | Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
| MESH:D054537 |
hypotension | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Hypotension | Blood Pressure Low Hypotension Vascular | Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| MESH:D007022 |
impairment of ventricular function | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Ventricular Dysfunction | Dysfunction Ventricular Dysfunctions | A condition in which HEART VENTRICLES exhibit impaired function.
| MESH:D018754 |
metoprolol | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Metoprolol | AstraZeneca Brand of Metaoprolol Tartrate Seloken Beloc Duriles Beloc-Duriles BelocDuriles Betaloc Astra Betaloc-Astra BetalocAstra Betalok CGP 2175 CGP-2175 CGP2175 H 93 26 93-26 9326 Leiras Metoprolol Succinate or Metoprolol Lopressor Novartis Metprolol Spesicor Spesikor | A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
| MESH:D008790 |
diltiazem | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Diltiazem | Aldizem Biovail Brand of Diltiazem Hydrochloride CRD 401 CRD-401 CRD401 Cardil Cardizem Dilacor XR Dilren Malate Dilzem Tiazac Watson Pharmaceuticals Diltazem | A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
| MESH:D004110 |
propafenone | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Propafenone | Abbott Brand of Propafenone Hydrochloride Aliud Alpharma Apo-Propafenone Apotex Arythmol Azupharma Baxarytmon Cuxafenon Fenoprain Hexal Juta Jutanorm Kendrick Knoll Merck dura Nistaken Norfenon Pintoform Prolecofen Propafenon AL Minden (R)-Isomer (S)-Isomer (+-)-Isomer Propamerck Q-Pharm Rythmol Rytmo-Puren Rytmogenat ... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
| MESH:D011405 |
sparteine | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Sparteine | Anhydrous Sparteine Sulfate D-sparteine Depasan Retard Genisteine Alkaloid L-Sparteine Pachycarpine (1:1) Pentahydrate (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer Hydrochloride (7R-(7alpha,7aalpha,14alpha,14abeta))-Isomer Hydroiodide Monohydrochloride Monohydroiodide (7S-(7alpha,7aalpha,14alpha,14aalpha))-Isomer (+)-I... | A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
| MESH:D013034 |
debrisoquine | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Debrisoquin | Debrisoquin Debrisoquine Tendor | An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as hav... | MESH:D003647 |
adverse drug reactions | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | Drug-Related Side Effects and Adverse Reactions | Adverse Drug Event Events Reaction Reactions Related Side Effects and Effect Toxicities Toxicity Drug-Related Drugs of | Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| MESH:D064420 |
Triazolam | Triazolam-induced brief episodes of secondary mania in a depressed patient. | Triazolam | Apo Triazo Apo-Triazo Apotex Brand of Triazolam Gen Gen-Triazolam Genpharm Gerard Halcion Pfizer Trilam U 33,030 U-33,030 U33,030 | A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA a... | MESH:D014229 |
mania | Triazolam-induced brief episodes of secondary mania in a depressed patient. | Bipolar Disorder | Affective Psychosis Bipolar Depression Disorder Disorders Manic Mania Manias Depressive State States Manic-Depressive Psychoses | A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| MESH:D001714 |
depressed | Triazolam-induced brief episodes of secondary mania in a depressed patient. | Depressive Disorder | Depression Endogenous Neurotic Unipolar Depressions Depressive Disorder Disorders Neuroses Neurosis Syndrome Syndromes Melancholia Melancholias | An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| MESH:D003866 |
triazolam | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | Triazolam | Apo Triazo Apo-Triazo Apotex Brand of Triazolam Gen Gen-Triazolam Genpharm Gerard Halcion Pfizer Trilam U 33,030 U-33,030 U33,030 | A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA a... | MESH:D014229 |
mania | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | Bipolar Disorder | Affective Psychosis Bipolar Depression Disorder Disorders Manic Mania Manias Depressive State States Manic-Depressive Psychoses | A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| MESH:D001714 |
depressed | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | Depressive Disorder | Depression Endogenous Neurotic Unipolar Depressions Depressive Disorder Disorders Neuroses Neurosis Syndrome Syndromes Melancholia Melancholias | An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| MESH:D003866 |
organic mental disorder | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | Delirium, Dementia, Amnestic, Cognitive Disorders | Clerambault Syndrome Delirium Dementia Amnestic Cognitive Disorders Organic Mental Kandinsky Disorder Nonpsychotic Brain Psychotic Psychoses Traumatic | Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, trauma, or other causes.
| MESH:D019965 |
delirium | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | Delirium | Delirium of Mixed Origin Subacute Deliriums | A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)
| MESH:D003693 |
Manic | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | Bipolar Disorder | Affective Psychosis Bipolar Depression Disorder Disorders Manic Mania Manias Depressive State States Manic-Depressive Psychoses | A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| MESH:D001714 |
triazolo | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | Triazolam | Apo Triazo Apo-Triazo Apotex Brand of Triazolam Gen Gen-Triazolam Genpharm Gerard Halcion Pfizer Trilam U 33,030 U-33,030 U33,030 | A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA a... | MESH:D014229 |
muscular rigidity | On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. | Muscle Rigidity | Catatonic Rigidity Cogwheel Rigidities Extensor Extrapyramidal Gegenhalten Gegenhaltens Muscle Muscular Nuchal | Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICI... | MESH:D009127 |
morphine | On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. | Morphine | Chloride Morphine Contin MS Duramorph Morphia Sulfate (2:1) Anhydrous Pentahydrate Oramorph SR SDZ 202 250 202-250 202250 SDZ202 SDZ202-250 SDZ202250 | The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
| MESH:D009020 |
muscular rigidity | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | Muscle Rigidity | Catatonic Rigidity Cogwheel Rigidities Extensor Extrapyramidal Gegenhalten Gegenhaltens Muscle Muscular Nuchal | Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICI... | MESH:D009127 |
morphine | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | Morphine | Chloride Morphine Contin MS Duramorph Morphia Sulfate (2:1) Anhydrous Pentahydrate Oramorph SR SDZ 202 250 202-250 202250 SDZ202 SDZ202-250 SDZ202250 | The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
| MESH:D009020 |
rigidity | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | Muscle Rigidity | Catatonic Rigidity Cogwheel Rigidities Extensor Extrapyramidal Gegenhalten Gegenhaltens Muscle Muscular Nuchal | Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICI... | MESH:D009127 |
akinetic | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | Hypokinesia | Antiorthostatic Hypokinesia Hypokinesias Bradykinesia Bradykinesias Hypodynamia | Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged inactivity due to illness; and other conditions.
| MESH:D018476 |
hyperkinetic | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | Hyperkinesis | Generalized Hyperkinesia Hyperkinesias Hyperactivity Motor Hyperkinesis Hyperkinetic Movement Movements | Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.
| MESH:D006948 |
haloperidol | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | Haloperidol | Haldol Haloperidol | A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEAS... | MESH:D006220 |
Haloperidol | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | Haloperidol | Haldol Haloperidol | A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEAS... | MESH:D006220 |
Compression neuropathy | Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy. | Nerve Compression Syndromes | Compression Syndrome Nerve Syndromes Entrapment Neuropathies Entrapments External Internal Neuropathy | Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect.
| MESH:D009408 |
neuropathy of the radial nerve | Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy. | Radial Neuropathy | Crutch Palsies Palsy Lesion Radial Nerve Superficial Lesions Disease Diseases Neuropathies Neuropathy Saturday Night | Disease involving the RADIAL NERVE. Clinical features include weakness of elbow extension, elbow flexion, supination of the forearm, wrist and finger extension, and thumb abduction. Sensation may be impaired over regions of the dorsal forearm. Common sites of compression or traumatic injury include the AXILLA and radia... | MESH:D020425 |
pentazocine | Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy. | Pentazocine | Fortral Hydrochloride Pentazocine Lactate Lexir Talwin | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
| MESH:D010423 |
pentazocine | Fibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy has not previously been reported. In a 37-year-old woman with documented pentazocine-induced fibrous myopathy of triceps and deltoid mus... | Pentazocine | Fortral Hydrochloride Pentazocine Lactate Lexir Talwin | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
| MESH:D010423 |
compression neuropathy | Fibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy has not previously been reported. In a 37-year-old woman with documented pentazocine-induced fibrous myopathy of triceps and deltoid mus... | Nerve Compression Syndromes | Compression Syndrome Nerve Syndromes Entrapment Neuropathies Entrapments External Internal Neuropathy | Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect.
| MESH:D009408 |
myopathy | Fibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy has not previously been reported. In a 37-year-old woman with documented pentazocine-induced fibrous myopathy of triceps and deltoid mus... | Muscular Diseases | Muscle Disorder Disorders Muscular Disease Diseases Myopathic Condition Conditions Myopathies Myopathy | Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
| MESH:D009135 |
acute renal failure | Recurrent reversible acute renal failure from amphotericin. | Acute Kidney Injury | Acute Kidney Failure Failures Injuries Injury Insufficiencies Insufficiency Renal | Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| MESH:D058186 |
amphotericin | Recurrent reversible acute renal failure from amphotericin. | Amphotericin B | Amphocil Amphotericin B Cholesterol Dispersion Colloidal Fungizone | Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
| MESH:D000666 |
cirrhosis | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | Fibrosis | Cirrhosis Fibroses Fibrosis | Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| MESH:D005355 |
sporotrichosis | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | Sporotrichosis | Sporotrichoses Sporotrichosis | The commonest and least serious of the deep mycoses, characterized by nodular lesions of the cutaneous and subcutaneous tissues. It is caused by inhalation of contaminated dust or by infection of a wound.
| MESH:D013174 |
acute renal failure | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | Acute Kidney Injury | Acute Kidney Failure Failures Injuries Injury Insufficiencies Insufficiency Renal | Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| MESH:D058186 |
amphotericin B | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | Amphotericin B | Amphocil Amphotericin B Cholesterol Dispersion Colloidal Fungizone | Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
| MESH:D000666 |
renal failure | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | Renal Insufficiency | Failure Kidney Renal Failures Insufficiency Insufficiencies | Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLO... | MESH:D051437 |
renal dysfunction | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | Kidney Diseases | Disease Kidney Diseases | Pathological processes of the KIDNEY or its component tissues.
| MESH:D007674 |
amphotericin | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | Amphotericin B | Amphocil Amphotericin B Cholesterol Dispersion Colloidal Fungizone | Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
| MESH:D000666 |
pericardial effusion | Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. | Pericardial Effusion | Chylopericardium Chylopericardiums Effusion Pericardial Effusions Hemopericardium | Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.
| MESH:D010490 |
neuropathy | Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. | Nervous System Diseases | Disease Nervous System Diseases Disorder Neurologic Neurological Disorders | Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| MESH:D009422 |
amiodarone | Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. | Amiodarone | ASTA Medica Brand of Amiodarone Hydrochloride Alphapharm Amiobeta Amiodarex Amiodarona Amiohexal Aratac Armstrong Berenguer Infale Betapharm Braxan Corbionax Cordarex Cordarone G Gam Hexal Kordaron L 3428 L-3428 L3428 Leurquin Ortacrone Pharma Investi Rytmarone SKF 33134 A 33134-A 33134A Sanofi Winthrop Tachydaron Tran... | An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
| MESH:D000638 |
sinuatrial disease | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Cardiovascular Diseases | Cardiovascular Disease Diseases | Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
| MESH:D002318 |
amiodarone | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Amiodarone | ASTA Medica Brand of Amiodarone Hydrochloride Alphapharm Amiobeta Amiodarex Amiodarona Amiohexal Aratac Armstrong Berenguer Infale Betapharm Braxan Corbionax Cordarex Cordarone G Gam Hexal Kordaron L 3428 L-3428 L3428 Leurquin Ortacrone Pharma Investi Rytmarone SKF 33134 A 33134-A 33134A Sanofi Winthrop Tachydaron Tran... | An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
| MESH:D000638 |
supraventricular tachyarrhythmias | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Tachycardia, Supraventricular | Supraventricular Tachycardia Tachycardias | A generic expression for any tachycardia that originates above the BUNDLE OF HIS.
| MESH:D013617 |
pneumonitis | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Pneumonia | Experimental Lung Inflammation Inflammations Pulmonary Lobar Pneumonia Pneumonias Pneumonitides Pneumonitis | Inflammation of any part, segment or lobe, of the lung parenchyma.
| MESH:D011014 |
pericardial effusions | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Pericardial Effusion | Chylopericardium Chylopericardiums Effusion Pericardial Effusions Hemopericardium | Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.
| MESH:D010490 |
proximal motor neuropathy | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Neuromuscular Diseases | Amyotonia Congenita Benign Fasciculation-Cramp Syndrome Syndromes Cramp Fasciculation Cramp-Fasciculation Foley Denny Brown Foley-Denny-Brown Neuromuscular Disease Diseases Oppenheim Oppenheim's Oppenheims | A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.
| MESH:D009468 |
prednisolone | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Prednisolone | Di Adreson F Di-Adreson-F DiAdresonF Predate Prednisolone Predonine | A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
| MESH:D011239 |
steroid | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | Steroids | Catatoxic Steroids | A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydro... | MESH:D013256 |
Indomethacin | Indomethacin-induced renal insufficiency: recurrence on rechallenge. | Indomethacin | Amuno Hydrochloride Indomethacin Indocid Indocin Indomet 140 Indometacin Metindol Osmosin | A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
| MESH:D007213 |
renal insufficiency | Indomethacin-induced renal insufficiency: recurrence on rechallenge. | Renal Insufficiency | Failure Kidney Renal Failures Insufficiency Insufficiencies | Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLO... | MESH:D051437 |
renal failure | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Renal Insufficiency | Failure Kidney Renal Failures Insufficiency Insufficiencies | Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLO... | MESH:D051437 |
hyperkalemia | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Hyperkalemia | Hyperkalemia Hyperkalemias Hyperpotassemia Hyperpotassemias | Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th e... | MESH:D006947 |
cirrhosis | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Fibrosis | Cirrhosis Fibroses Fibrosis | Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| MESH:D005355 |
ascites | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Ascites | Ascites | Accumulation or retention of free fluid within the peritoneal cavity.
| MESH:D001201 |
cor pulmonale | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Pulmonary Heart Disease | Cor Pulmonale Disease Pulmonary Heart Diseases | Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.
| MESH:D011660 |
indomethacin | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Indomethacin | Amuno Hydrochloride Indomethacin Indocid Indocin Indomet 140 Indometacin Metindol Osmosin | A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
| MESH:D007213 |
oliguria | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Oliguria | Oliguria Oligurias | Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1 ml/kg/hr depending on the age.
| MESH:D009846 |
prostaglandins | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Prostaglandins | Prostaglandins Prostanoids | A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
| MESH:D011453 |
acute renal failure | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | Acute Kidney Injury | Acute Kidney Failure Failures Injuries Injury Insufficiencies Insufficiency Renal | Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| MESH:D058186 |
flunitrazepam | Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers. | Flunitrazepam | 1A Brand of Flunitrazepam Fluni Pharma Flunibeta Flunimerck Fluninoc Teva neuraxpharm ratiopharm Flunitrazepam-Teva Flunitrazepam-neuraxpharm Flunitrazepam-ratiopharm Fluridrazepam Hexal Merck dura Narcozep RO-5-4200 RO54200 Roche Rohipnol Rohypnol betapharm ct Arzneimittel ct-Arzneimittel flunizep von | A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
| MESH:D005445 |
Flunitrazepam | Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chromatography, in a smaller number of the subjects. The most striking effect was sedation which increased with the dose, 2 mg producing ... | Flunitrazepam | 1A Brand of Flunitrazepam Fluni Pharma Flunibeta Flunimerck Fluninoc Teva neuraxpharm ratiopharm Flunitrazepam-Teva Flunitrazepam-neuraxpharm Flunitrazepam-ratiopharm Fluridrazepam Hexal Merck dura Narcozep RO-5-4200 RO54200 Roche Rohipnol Rohypnol betapharm ct Arzneimittel ct-Arzneimittel flunizep von | A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
| MESH:D005445 |
Dizziness | Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chromatography, in a smaller number of the subjects. The most striking effect was sedation which increased with the dose, 2 mg producing ... | Dizziness | Dizziness Dizzyness Light Headedness Light-Headedness Lightheadedness Orthostasis | An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
| MESH:D004244 |
pain | Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chromatography, in a smaller number of the subjects. The most striking effect was sedation which increased with the dose, 2 mg producing ... | Pain | Ache Aches Burning Pain Pains Crushing Migratory Radiating Splitting Physical Suffering Sufferings | An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| MESH:D010146 |
flunitrazepam | Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chromatography, in a smaller number of the subjects. The most striking effect was sedation which increased with the dose, 2 mg producing ... | Flunitrazepam | 1A Brand of Flunitrazepam Fluni Pharma Flunibeta Flunimerck Fluninoc Teva neuraxpharm ratiopharm Flunitrazepam-Teva Flunitrazepam-neuraxpharm Flunitrazepam-ratiopharm Fluridrazepam Hexal Merck dura Narcozep RO-5-4200 RO54200 Roche Rohipnol Rohypnol betapharm ct Arzneimittel ct-Arzneimittel flunizep von | A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
| MESH:D005445 |
timolol | Changes in heart size during long-term timolol treatment after myocardial infarction. | Timolol | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol Blocadren Hemihydrate Timolol L 714,465 L-714,465 L714,465 MK 950 MK-950 MK950 Optimol Timacar Maleate (1:1) Salt Timoptic Timoptol | A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
| MESH:D013999 |
myocardial infarction | Changes in heart size during long-term timolol treatment after myocardial infarction. | Myocardial Infarction | Cardiovascular Stroke Strokes Infarct Myocardial Infarction Infarctions Infarcts | NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| MESH:D009203 |
timolol | The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in co... | Timolol | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol Blocadren Hemihydrate Timolol L 714,465 L-714,465 L714,465 MK 950 MK-950 MK950 Optimol Timacar Maleate (1:1) Salt Timoptic Timoptol | A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
| MESH:D013999 |
myocardial infarction | The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in co... | Myocardial Infarction | Cardiovascular Stroke Strokes Infarct Myocardial Infarction Infarctions Infarcts | NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| MESH:D009203 |
bradycardia | The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in co... | Bradycardia | Bradyarrhythmia Bradyarrhythmias Bradycardia Bradycardias | Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| MESH:D001919 |
cardiomegaly | The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in co... | Cardiomegaly | Cardiac Hypertrophy Cardiomegaly Enlarged Heart Enlargement | Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
... | MESH:D006332 |
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