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<s> [INST] What is the outlook for Hereditary Neuropathies ?[/INST] The prognosis for individuals with hereditary neuropathies depends upon the type of neuropathy. Some hereditary neuropathies have very mild symptoms and may go undiagnosed for many years. Other types are more severe and are associated with more disabil... |
<s> [INST] what research (or clinical trials) is being done for Hereditary Neuropathies ?[/INST] The NINDS supports research on neuromuscular disorders, such as hereditary neuropathies, aimed at learning more about these disorders and finding ways to prevent and treat them.</s> |
<s> [INST] What is (are) Glossopharyngeal Neuralgia ?[/INST] Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck) and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middl... |
<s> [INST] What are the treatments for Glossopharyngeal Neuralgia ?[/INST] Most doctors will attempt to treat the pain first with drugs. Some individuals respond well to anticonvulsant drugs, such as carbamazepine and gabapentin. Surgical options, including nerve resection, tractotomy, or microvascular decompression, s... |
<s> [INST] What is the outlook for Glossopharyngeal Neuralgia ?[/INST] Some individuals recover from an initial attack and never have another. Others will experience clusters of attacks followed by periods of short or long remission. Individuals may lose weight if they fear that chewing, drinking, or eating will cause ... |
<s> [INST] what research (or clinical trials) is being done for Glossopharyngeal Neuralgia ?[/INST] The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes at the National Institutes of Health conduct research related to GN and support additional research through grants to major researc... |
<s> [INST] What is (are) Gaucher Disease ?[/INST] Gaucher disease is one of the inherited metabolic disorders known as lipid storage diseases. Lipids are fatty materials that include oils, fatty acids, waxes, and steroids (such as cholesterol and estrogen). Gaucher disease is caused by a deficiency of the enzyme glucoc... |
<s> [INST] What are the treatments for Gaucher Disease ?[/INST] Enzyme replacement therapy is available for most people with types 1 and 3 Gaucher disease. Given intravenously every two weeks, this therapy decreases liver and spleen size, reduces skeletal abnormalities, and reverses other symptoms of the disorder. The ... |
<s> [INST] What is the outlook for Gaucher Disease ?[/INST] Enzyme replacement therapy is very beneficial for type 1 and most type 3 individuals with this condition. Successful bone marrow transplantation can reverse the non-neurological effects of the disease, but the procedure carries a high risk and is rarely perfor... |
<s> [INST] what research (or clinical trials) is being done for Gaucher Disease ?[/INST] The mission of the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health), is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to redu... |
<s> [INST] What is (are) Shingles ?[/INST] Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox the varicella-zoster virus. The first sign of shingles is often burning or tingling pain (which can be severe), or sometimes numbness or itch,genera... |
<s> [INST] What are the treatments for Shingles ?[/INST] The severity and duration of an attack of shingles can be significantly reduced by immediate treatment with antiviral drugs, which include acyclovir, valcyclovir, or famcyclovir. Antiviral drugs may also help stave off the painful after-effects of shingles known ... |
<s> [INST] What is the outlook for Shingles ?[/INST] For most healthy people who receive treatment soon after the outbreak of blisters, the lesions heal, the pain subsides within 3 to 5 weeks, and the blisters often leave no scars. However, shingles is a serious threat in immunosuppressed individuals for example, thos... |
<s> [INST] what research (or clinical trials) is being done for Shingles ?[/INST] The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge of the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. The NINDS supports... |
<s> [INST] What is (are) Leigh's Disease ?[/INST] Leigh's disease is a rare inherited neurometabolic disorder that affects the central nervous system. This progressive disorder begins in infants between the ages of three months and two years.Rarely, it occurs in teenagers and adults.Leigh's disease can be caused by mut... |
<s> [INST] What are the treatments for Leigh's Disease ?[/INST] The most common treatment for Leigh's disease is thiamine or Vitamin B1. Oral sodium bicarbonate or sodium citrate may also be prescribed to manage lactic acidosis. Researchers are currently testing dichloroacetate to establish its effectiveness in treatin... |
<s> [INST] What is the outlook for Leigh's Disease ?[/INST] The prognosis for individuals with Leigh's disease is poor. Individuals who lack mitochondrial complex IV activity and those with pyruvate dehydrogenase deficiency tend to have the worst prognosis and die within a few years. Those with partial deficiencies hav... |
<s> [INST] what research (or clinical trials) is being done for Leigh's Disease ?[/INST] The NINDS supports and encourages a broad range of basic and clinical research on neurogenetic disorders such as Leigh's disease. The goal of this research is to understand what causes these disorders and then to apply these findin... |
<s> [INST] What is (are) Kuru ?[/INST] Kuru is a rare and fatal brain disorder that occurred at epidemic levels during the 1950s-60s among the Fore people in the highlands of New Guinea. The disease was the result of the practice of ritualistic cannibalism among the Fore, in which relatives prepared and consumed the ti... |
<s> [INST] What are the treatments for Kuru ?[/INST] There were no treatments that could control or cure kuru, other than discouraging the practice of cannibalism. Currently, there are no cures or treatments for any of the other TSE diseases.</s> |
<s> [INST] What is the outlook for Kuru ?[/INST] Similar to other the TSEs, kuru had a long incubation period; it was years or even decades before an infected person showed symptoms. Because kuru mainly affected the cerebellum, which is responsible for coordination, the usual first symptoms were an unsteady gait, tremo... |
<s> [INST] what research (or clinical trials) is being done for Kuru ?[/INST] The NINDS funds research to better understand the genetic, molecular, and cellular mechanisms that underlie the TSE diseases. Findings from this research will lead to ways to diagnose, treat, prevent, and ultimately cure these diseases.</s> |
<s> [INST] What is (are) Neurodegeneration with Brain Iron Accumulation ?[/INST] Neurodegeneration with brain iron accumulation (NBIA) is a rare, inherited, neurological movement disorder characterized by an abnormal accumulation of iron in the brain and progressive degeneration of the nervous system. Symptoms, which v... |
<s> [INST] What are the treatments for Neurodegeneration with Brain Iron Accumulation ?[/INST] There is no cure for NBIA, nor is there a standard course of treatment. Treatment is symptomatic and supportive, and may include physical or occupational therapy, exercise physiology, and/or speech pathology. Many medications... |
<s> [INST] What is the outlook for Neurodegeneration with Brain Iron Accumulation ?[/INST] NBIA is a progressive condition. Most individuals experience periods of rapid decline lasting weeks to months, with relatively stable periods in between. The rate of progression correlates with the age at onset, meaning that chil... |
<s> [INST] what research (or clinical trials) is being done for Neurodegeneration with Brain Iron Accumulation ?[/INST] The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and nervous system, and to use that knowledge to reduce the burden o... |
<s> [INST] What is (are) Pompe Disease ?[/INST] Pompe disease is a rare (estimated at 1 in every 40,000 births), inherited and often fatal disorder that disables the heart and skeletal muscles. It is caused by mutations in a gene that makes an enzyme called acid alpha-glucosidase (GAA). Normally, the body uses GAA to b... |
<s> [INST] What are the treatments for Pompe Disease ?[/INST] Individuals with Pompe disease are best treated by a team of specialists (such as cardiologist, neurologist, and respiratory therapist) knowledgeable about the disease, who can offer supportive and symptomatic care. The discovery of the GAA gene has led to r... |
<s> [INST] What is the outlook for Pompe Disease ?[/INST] Without enzyme replacement therapy, the hearts of babies with infantile onset Pompe disease progressively thicken and enlarge. These babies die before the age of one year from either cardiorespiratory failure or respiratory infection. For individuals with late o... |
<s> [INST] what research (or clinical trials) is being done for Pompe Disease ?[/INST] The National Institute of Neurological Disorders and Stroke (NINDS) supports Pompe research through grants to major research institutions across the country. Research related to Pompe disease is conducted in one of the laboratories o... |
<s> [INST] What is (are) Dysgraphia ?[/INST] Dysgraphia is a neurological disorder characterized by writing disabilities. Specifically, the disorder causes a person's writing to be distorted or incorrect. In children, the disorder generally emerges when they are first introduced to writing. They make inappropriately si... |
<s> [INST] What are the treatments for Dysgraphia ?[/INST] Treatment for dysgraphia varies and may include treatment for motor disorders to help control writing movements. Other treatments may address impaired memory or other neurological problems. Some physicians recommend that individuals with dysgraphia use computer... |
<s> [INST] What is the outlook for Dysgraphia ?[/INST] Some individuals with dysgraphia improve their writing ability, but for others, the disorder persists.</s> |
<s> [INST] what research (or clinical trials) is being done for Dysgraphia ?[/INST] The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) support dysgraphia research through grants to major medical institutions across the country. Much of thi... |
<s> [INST] What is (are) Orthostatic Hypotension ?[/INST] Orthostatic hypotension is a sudden fall in blood pressure that occurs when a person assumes a standing position. It is due to a lesion of the baroreflex loop, which senses a change in blood pressure and adjusts heart rate and activates sympathetic nerve system ... |
<s> [INST] What are the treatments for Orthostatic Hypotension ?[/INST] When orthostatic hypotension is caused by hypovolemia due to medications, the disorder may be reversed by adjusting the dosage or by discontinuing the medication. When the condition is caused by prolonged bed rest, improvement may occur by sitting ... |
<s> [INST] What is the outlook for Orthostatic Hypotension ?[/INST] The prognosis for individuals with orthostatic hypotension depends on the underlying cause of the condition.</s> |
<s> [INST] what research (or clinical trials) is being done for Orthostatic Hypotension ?[/INST] The NINDS supports research on conditions such as neurogenic orthostatic hypotension aimed at increasing scientific understanding of the condition and finding ways to treat and prevent it.</s> |
<s> [INST] What is (are) Huntington's Disease ?[/INST] Huntington's disease (HD) is an inherited disorder that causes degeneration of brain cells, called neurons, in motor control regions of the brain, as well as other areas. Symptoms of the disease, which gets progressively worse, include uncontrolled movements (calle... |
<s> [INST] What are the treatments for Huntington's Disease ?[/INST] There is no treatment that can stop or reverse the course of HD. Tetrabenazine is prescribed for treating Huntingtons-associated chorea. It is the only drug approved by the U.S. Food and Drug Administration specifically for use against HD. Antipsychot... |
<s> [INST] What is the outlook for Huntington's Disease ?[/INST] Huntingtons disease causes disability that gets worse over time. People with this disease usually die within 15 to 20 years following diagnosis. At this time, no treatment is available to slow, stop or reverse the course of HD.</s> |
<s> [INST] what research (or clinical trials) is being done for Huntington's Disease ?[/INST] The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and nervous system, and to use that knowledge to reduce the burden of neurological disease. A ... |
<s> [INST] What is (are) Transmissible Spongiform Encephalopathies ?[/INST] Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare degenerative brain disorders characterized by tiny holes that give the brain a "spongy" appearance. These holes can be seen when brain tissue is... |
<s> [INST] What are the treatments for Transmissible Spongiform Encephalopathies ?[/INST] TSEs tend to progress rapidly and usually culminate in death over the course of a few months to a few years.</s> |
<s> [INST] What is the outlook for Transmissible Spongiform Encephalopathies ?[/INST] There is currently no treatment that can halt progression of any of the TSEs. Treatment is aimed at alleviating symptoms and making the patient as comfortable as possible. A clinical trial of a potential therapy for CJD is expected to... |
<s> [INST] what research (or clinical trials) is being done for Transmissible Spongiform Encephalopathies ?[/INST] The NINDS conducts and supports research on TSEs. This research is aimed at determining how abnormal prion proteins lead to disease, at finding better tests for diagnosing CJD and other disorders, and ulti... |
<s> [INST] What is (are) Neurosarcoidosis ?[/INST] Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system. Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and sys... |
<s> [INST] What are the treatments for Neurosarcoidosis ?[/INST] There is no agreed upon standard of treatment for neurosarcoidosis. Doctors generally recommend corticosteroid therapy as first-line therapy for individuals with the condition. Additional treatment with immunomodulatory drugs such as hydroxychloroquine, p... |
<s> [INST] What is the outlook for Neurosarcoidosis ?[/INST] The prognosis for patients with neurosarcoidosis varies. Approximately two-thirds of those with the condition will recover completely; the remainder will have a chronically progressing or on-and-off course of illness. Complications resulting from immunosuppre... |
<s> [INST] what research (or clinical trials) is being done for Neurosarcoidosis ?[/INST] The National Institute of Neurological Disorders and Stroke (NINDS) has joined with other institutes of the National Institutes of Health (NIH) to form a trans-NIH working group to coordinate and fund research into the disease mec... |
<s> [INST] What is (are) Mitochondrial Myopathy ?[/INST] Mitochondrial myopathies are a group of neuromuscular diseases caused by damage to the mitochondriasmall, energy-producing structures that serve as the cells' "power plants." Nerve cells in the brain and muscles require a great deal of energy, and thus appear to ... |
<s> [INST] What are the treatments for Mitochondrial Myopathy ?[/INST] Although there is no specific treatment for any of the mitochondrial myopathies, physical therapy may extend the range of movement of muscles and improve dexterity. Vitamin therapies such as riboflavin, coenzyme Q, and carnitine (a specialized amino... |
<s> [INST] What is the outlook for Mitochondrial Myopathy ?[/INST] The prognosis for patients with mitochondrial myopathies varies greatly, depending largely on the type of disease and the degree of involvement of various organs. These disorders cause progressive weakness and can lead to death.</s> |
<s> [INST] what research (or clinical trials) is being done for Mitochondrial Myopathy ?[/INST] The NINDS conducts and supports research on mitochondrial myopathies. The goals of this research are to increase scientific understanding of these disorders and to find ways to effectively treat, prevent, or potentially cure... |
<s> [INST] What is (are) Lissencephaly ?[/INST] Lissencephaly, which literally means "smooth brain," is a rare, gene-linked brain malformation characterized by the absence of normal convolutions (folds) in the cerebral cortex and an abnormally small head (microcephaly). In the usual condition of lissencephaly, children... |
<s> [INST] What are the treatments for Lissencephaly ?[/INST] There is no cure for lissencephaly, but children can show progress in their development over time. Supportive care may be needed to help with comfort, feeding, and nursing needs. Seizures may be particularly problematic but anticonvulsant medications can hel... |
<s> [INST] What is the outlook for Lissencephaly ?[/INST] The prognosis for children with lissencephaly depends on the degree of brain malformation. Many will die before the age of 10 years. The cause of death is usually aspiration of food or fluids, respiratory disease, or severe seizures. Some will survive, but show ... |
<s> [INST] what research (or clinical trials) is being done for Lissencephaly ?[/INST] The NINDS conducts and supports a wide range of studies that explore the complex systems of normal brain development, including neuronal migration. Recent studies have identified genes that are responsible for lissencephaly. The know... |
<s> [INST] What is (are) Multiple System Atrophy with Orthostatic Hypotension ?[/INST] Multiple system atrophy with orthostatic hypotension is the current classification for a neurological disorder that was once called Shy-Drager syndrome. A progressive disorder of the central and autonomic nervous systems, it is chara... |
<s> [INST] What are the treatments for Multiple System Atrophy with Orthostatic Hypotension ?[/INST] There is no cure for multiple system atrophy with orthostatic hypotension. Treatment is aimed at controlling symptoms. Anti-Parkinson medication such as Sinemet may improve the general sense of well-being. Medications t... |
<s> [INST] What is the outlook for Multiple System Atrophy with Orthostatic Hypotension ?[/INST] Most individuals with multiple system atrophy with orthostatic hypotension die within 7 to 10 years after the onset of symptoms. A problem with the respiratory system is the most common cause of death.</s> |
<s> [INST] what research (or clinical trials) is being done for Multiple System Atrophy with Orthostatic Hypotension ?[/INST] The NINDS supports research on disorders of the autonomic nervous system, including multiple system atrophy with orthostatic hypotension. This research is aimed at developing techniques to diagn... |
<s> [INST] What is (are) Transient Ischemic Attack ?[/INST] A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as lo... |
<s> [INST] What are the treatments for Transient Ischemic Attack ?[/INST] Because there is no way to tell whether symptoms are from a TIA or an acute stroke, patients should assume that all stroke-like symptoms signal an emergency and should not wait to see if they go away. A prompt evaluation (within 60 minutes) is ne... |
<s> [INST] What is the outlook for Transient Ischemic Attack ?[/INST] TIAs are often warning signs that a person is at risk for a more serious and debilitating stroke. About one-third of those who have a TIA will have an acute stroke some time in the future. Many strokes can be prevented by heeding the warning signs of... |
<s> [INST] what research (or clinical trials) is being done for Transient Ischemic Attack ?[/INST] NINDS is the leading supporter of research on stroke and TIA in the U.S. and sponsors studies ranging from clinical trials to investigations of basic biological mechanisms as well as studies with animals.</s> |
<s> [INST] What is (are) Porencephaly ?[/INST] Porencephaly is an extremely rare disorder of the central nervous system in which a cyst or cavity filled with cerebrospinal fluid develops in the brain. It is usually the result of damage from stroke or infection after birth (the more common type), but it can also be caus... |
<s> [INST] What are the treatments for Porencephaly ?[/INST] Treatment may include physical therapy, medication for seizures, and the placement of a shunt in the brain to remove excess fluid in the brain.</s> |
<s> [INST] What is the outlook for Porencephaly ?[/INST] The prognosis for children with porencephaly varies according to the location and extent of the cysts or cavities. Some children with this disorder develop only minor neurological problems and have normal intelligence, while others may be severely disabled and di... |
<s> [INST] what research (or clinical trials) is being done for Porencephaly ?[/INST] The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct research related to porencephaly in laboratories at the NIH and also support additional resear... |
<s> [INST] What is (are) Machado-Joseph Disease ?[/INST] Machado-Joseph disease (MJD), which is also called spinocerebellar ataxia type 3, is a rare hereditary ataxia (ataxia is a medical term meaning lack of muscle control). The disease is characterized by slowly progressive clumsiness and weakness in the arms and leg... |
<s> [INST] What are the treatments for Machado-Joseph Disease ?[/INST] MJD is incurable, but some symptoms of the disease can be treated. For those individuals who show parkinsonian features, levodopa therapy can help for many years. Treatment with antispasmodic drugs, such as baclofen, can help reduce spasticity. Botu... |
<s> [INST] What is the outlook for Machado-Joseph Disease ?[/INST] The severity of the disease is related to the age of onset, with earlier onset associated with more severe forms of the disease. Symptoms can begin any time between early adolescence and about 70 years of age. MJD is a progressive disease, meaning that ... |
<s> [INST] what research (or clinical trials) is being done for Machado-Joseph Disease ?[/INST] The National Institute of Neurological Disorders and Stroke (NINDS) conducts MJD research in its laboratories at the National Institutes of Health (NIH) and also supports MJD research through grants to major medical institut... |
<s> [INST] What is (are) Sleep Apnea ?[/INST] Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep. These episodes usually last 10 seconds or more and occur repeatedly throughout the night. People with sleep apnea will partially awaken as they struggle to breathe, but in... |
<s> [INST] What are the treatments for Sleep Apnea ?[/INST] There are a variety of treatments for sleep apnea, depending on an individuals medical history and the severity of the disorder. Most treatment regimens begin with lifestyle changes, such as avoiding alcohol and medications that relax the central nervous syste... |
<s> [INST] What is the outlook for Sleep Apnea ?[/INST] Untreated, sleep apnea can be life threatening. Excessive daytime sleepiness can cause people to fall asleep at inappropriate times, such as while driving. Sleep apnea also appears to put individuals at risk for stroke and transient ischemic attacks (TIAs, also kn... |
<s> [INST] what research (or clinical trials) is being done for Sleep Apnea ?[/INST] The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct research related to sleep apnea in laboratories at the NIH, and also support additional researc... |
<s> [INST] What is (are) Central Pontine Myelinolysis ?[/INST] Central pontine myelinolysis (CPM) is a neurological disorder that most frequently occurs after too rapid medical correction of sodium deficiency (hyponatremia). The rapid rise in sodium concentration is accompanied by the movement of small molecules and pu... |
<s> [INST] What are the treatments for Central Pontine Myelinolysis ?[/INST] The ideal treatment for myelinolysis is to prevent the disorder by identifying individuals at risk and following careful guidelines for evaluation and correction of hyponatremia. These guidelines aim to safely restore the serum sodium level, w... |
<s> [INST] What is the outlook for Central Pontine Myelinolysis ?[/INST] The prognosis for myelinolysis varies. Some individuals die and others recover completely. Although the disorder was originally considered to have a mortality rate of 50 percent or more, improved imaging techniques and early diagnosis have led to ... |
<s> [INST] what research (or clinical trials) is being done for Central Pontine Myelinolysis ?[/INST] The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge of the brain and nervous system and to use that knowledge to reduce the burden of neurological disease... |
<s> [INST] What is (are) Von Hippel-Lindau Disease (VHL) ?[/INST] von Hippel-Lindau disease (VHL) is a rare, genetic multi-system disorder in which non-cancerous tumors grow in certain parts of the body. Slow-growing hemgioblastomas -- benign tumors with many blood vessels -- may develop in the brain, spinal cord, the ... |
<s> [INST] What are the treatments for Von Hippel-Lindau Disease (VHL) ?[/INST] Treatment for VHL varies according to the location and size of the tumor. In general, the objective of treatment is to treat the tumors before they grow to a size large enough to cause permanent problems by putting pressure on the brain or ... |
<s> [INST] What is the outlook for Von Hippel-Lindau Disease (VHL) ?[/INST] The prognosis for individuals with VHL depends on then number, location, and complications of the tumors. Untreated, VHL may result in blindness and/or permanent brain damage. With early detection and treatment the prognosis is significantly im... |
<s> [INST] what research (or clinical trials) is being done for Von Hippel-Lindau Disease (VHL) ?[/INST] The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and nervous system, and to use that knowledge to reduce the burden of neurological ... |
<s> [INST] What is (are) Neuroaxonal dystrophy ?[/INST] Infantile neuroaxonal dystrophy (INAD) is a rare inherited neurological disorder. It affects axons, the part of a nerve cell that carries messages from the brain to other parts of the body, and causes progressive loss of vision, muscular control, and mental skills... |
<s> [INST] What are the treatments for Neuroaxonal dystrophy ?[/INST] There is no cure for INAD and no treatment that can stop the progress of the disease. Treatment is symptomatic and supportive. Doctors can prescribe medications for pain relief and sedation. Physiotherapists and other physical therapists can teach pa... |
<s> [INST] What is the outlook for Neuroaxonal dystrophy ?[/INST] INAD is a progressive disease. Once symptoms begin, they will worsen over time. Generally, a babys development starts to slow down between the ages of 6 months to 3 years. The first symptoms may be slowing of motor and mental development, followed by los... |
<s> [INST] what research (or clinical trials) is being done for Neuroaxonal dystrophy ?[/INST] Researchers continue to search for the defective gene that causes INAD in hopes of developing drugs that can stop the disease. The National Institute of Neurological Disorders and Stroke (NINDS) conducts research related to I... |
<s> [INST] What is (are) Chiari Malformation ?[/INST] Chiari malformations (CMs) are structural defects in the cerebellum, the part of the brain that controls balance. When the indented bony space at the lower rear of the skull is smaller than normal, the cerebellum and brain stem can be pushed downward. The resulting ... |
<s> [INST] What are the treatments for Chiari Malformation ?[/INST] Medications may ease certain symptoms, such as pain. Surgery is the only treatment available to correct functional disturbances or halt the progression of damage to the central nervous system. More than one surgery may be needed to treat the condition.... |
<s> [INST] What is the outlook for Chiari Malformation ?[/INST] Many people with Type I CM are asymptomatic and do not know they have the condition. Many individuals with the more severe types of CM and have surgery see a reduction in their symptoms and/or prolonged periods of relative stability, although paralysis is ... |
<s> [INST] what research (or clinical trials) is being done for Chiari Malformation ?[/INST] The NINDS supports research on disorders of the brain and nervous system such as Chiari malformations. The goals of this research are to increase scientific understanding of these disorders and to find ways to prevent, treat, a... |
<s> [INST] What is (are) Neurotoxicity ?[/INST] Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of t... |
<s> [INST] What are the treatments for Neurotoxicity ?[/INST] Treatment involves eliminating or reducing exposure to the toxic substance, followed by symptomatic and supportive therapy.</s> |
<s> [INST] What is the outlook for Neurotoxicity ?[/INST] The prognosis depends upon the length and degree of exposure and the severity of neurological injury. In some instances, exposure to neurotoxicants can be fatal. In others, patients may survive but not fully recover. In other situations, many individuals recover... |
<s> [INST] what research (or clinical trials) is being done for Neurotoxicity ?[/INST] The NINDS supports research on disorders of the brain and nervous system such as neurotoxicity, aimed at learning more about these disorders and finding ways to prevent and treat them. Scientists are investigating the role occupation... |
<s> [INST] What is (are) Congenital Myasthenia ?[/INST] All forms of myasthenia are due to problems in the communication between nerve cells and muscles. Most involve the activities of neurotransmitters. Neurotransmitters are chemicals that allow neurons to relay information from one cell to the next. For neurotransmit... |
<s> [INST] What are the treatments for Congenital Myasthenia ?[/INST] The possibilities for treatment depend on the specific subtype of congenital myasthenia. Most treatments attempt to improve the signaling between nerve cell and muscle. These drugs include pyridostigmine, fluoxetine, ephedrine, and 3,4-diaminopyridin... |
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