Entry stringlengths 6 10 | Entry Name stringlengths 5 11 | Sequence stringlengths 2 35.2k | EC number stringlengths 7 118 ⌀ | Cofactor stringlengths 38 1.77k ⌀ | Gene Ontology (biological process) stringlengths 18 11.3k ⌀ | Gene Ontology (cellular component) stringlengths 17 1.75k ⌀ | Gene Ontology (molecular function) stringlengths 24 2.09k ⌀ | Pfam stringlengths 8 232 ⌀ | Gene3D stringlengths 10 250 ⌀ | Protein families stringlengths 9 237 ⌀ | Post-translational modification stringlengths 16 8.52k ⌀ | Subcellular location [CC] stringlengths 29 6.18k ⌀ | Catalytic activity stringlengths 64 35.7k ⌀ | Kinetics stringlengths 69 11.7k ⌀ | Pathway stringlengths 27 908 ⌀ | pH dependence stringlengths 64 955 ⌀ | Temperature dependence stringlengths 70 1.16k ⌀ | Function [CC] stringlengths 17 15.3k ⌀ | Organism stringlengths 8 196 |
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B3H754 | APD3_ARATH | MGSIRGDLQPLFVMPPPPLDEDCDDIFNSDESSWGLLSLSCFGIIMGLWFFASVCLIFGVYGSETVWLGPNSSILVKPSSIFVKSIKVKELDFSKPGLQLYGFNGQSTPSGYFVNWTESRVLSVSQNSYKGWPYYLNRGTHMNISYNILPKGSAVRLVITEGSQVIGMPFFYRSSLKDIAFRDTAWSWNLIQGSGMIQLDISKSKGYYLTVANLKRKDIEVELDIDVKAVLYDTKQTSYNCSFSNGECSFKMNERYPVENYAVVTSPALGQGVSIDDEWYIELSYQPRLIAYGSFTGVLLSFMLVAIHFCNKLKCCGGEG... | 2.3.2.27 | null | mitotic cell cycle [GO:0000278]; pollen development [GO:0009555]; protein ubiquitination [GO:0016567] | endosome [GO:0005768]; plant-type vacuole membrane [GO:0009705] | metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] | PF16041;PF16040;PF13920; | 3.30.40.10; | null | null | SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q0WS06}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:Q0WS06}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q6DBH0}; | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6DBH0}. | null | null | FUNCTION: Involved in pollen mitosis II (PMII) regulation during male gametogenesis. {ECO:0000269|PubMed:22897245}. | Arabidopsis thaliana (Mouse-ear cress) |
B3H7A9 | PXG7_ARATH | MSHQTVALASKAKSPKPKRGKLDKEKMTALEKHVSFFDRNKDGTVYPWETYQGFRALGTGRLLAAFVAIFINMGLSKKTRPGKGFSPLFPIDVKNSHLCMHGSDTDVYDDDGRFVESKFEEIFNKHARTHKDALTAEEIQKMLKTNRDPFDITGWLSDYGEWKILHTLAQDKNGLLSEKSVRAIYDGSLFHQLEKKRSSSSSRGKKQKLP | 1.11.2.3 | COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000250}; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group. {ECO:0000250}; COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; | null | extracellular region [GO:0005576] | 18-hydroxyoleate peroxygenase activity [GO:0102070]; calcium ion binding [GO:0005509]; lipase activity [GO:0016298]; monooxygenase activity [GO:0004497]; plant seed peroxidase activity [GO:1990137] | PF05042; | 1.10.238.10; | Caleosin family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11431566}. | CATALYTIC ACTIVITY: Reaction=RH + ROOH = ROH + ROH.; EC=1.11.2.3; | null | null | null | null | FUNCTION: Probable calcium-binding peroxygenase. May be involved in pollination. | Arabidopsis thaliana (Mouse-ear cress) |
B3H7I1 | SOP12_ARATH | MRNTISSKMGQVLIVLLLLCTVLCRTESALPSGQHSVLLTGRRLMGSGASGPVRSSQSSQAGGRFNDADPIAIDYGKY | null | null | cell-cell signaling involved in cell fate commitment [GO:0045168]; defense response to insect [GO:0002213]; indole glucosinolate biosynthetic process [GO:0009759]; jasmonic acid biosynthetic process [GO:0009695]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; plant-type cell wall organiz... | apoplast [GO:0048046]; plasma membrane [GO:0005886] | LRR domain binding [GO:0030275]; receptor serine/threonine kinase binding [GO:0033612] | null | null | Serine rich endogenous peptide (SCOOP) phytocytokine family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34535661}. Secreted, extracellular space, apoplast {ECO:0000269|PubMed:34535661}. Note=The precursor of SCOOP12, PROSCOOP12, accumulates at the plasma membrane and is proteolytically cleaved to release the SCOOP12 in the apoplasm. {ECO:0000269|PubMed:34535661}. | null | null | null | null | null | FUNCTION: Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including root growth prevention, phospholipid signaling pathway activation (e.g.... | Arabidopsis thaliana (Mouse-ear cress) |
B3KU38 | IQIP1_HUMAN | MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQ... | null | null | negative regulation of cytoskeleton organization [GO:0051494]; positive regulation of hippo signaling [GO:0035332] | axon initial segment [GO:0043194]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] | null | PF15157;PF10148; | null | null | null | SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:A0A088MLT8}. Cytoplasm {ECO:0000269|PubMed:17045569}. Note=Localizes to the axon initial segments (AIS) and nodes of Ranvier of neurons and is absent from dendrites. {ECO:0000250|UniProtKB:A0A088MLT8}. | null | null | null | null | null | FUNCTION: May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarity). {ECO:0000250|UniProtKB:A0A088MLT8, ECO:0000269|PubMed:2595094... | Homo sapiens (Human) |
B3L2V1 | PSD_PLAKH | MKKNGRDNNFYHLYKNKYLITGVTILSFILMFQYKYHEVLTLHDNSENAVQSSKLFWARLLFGRTRSRITGQILKMEIPNTYRLFIFNFLIKYMHINKEEIKYPIESYKSIGDFFSRYIREETRPIGDVSDYSIVSPCDSELIDYGELTSEYLENIKGVKFNVNTFLGSKFQKKHNDGSTKFFYAIFYLSPKKYHHFHAPFNFKYKIRRHISGELFPVFQGMFKFINNLFNINERVILSGEWKGGNVYYAAISAYNVGNIKIINDEELVTNNLRHQLSYMGGDINTKIFDSYKSVEVGDEIGEFRMGSSIVVIFENKKDF... | 4.1.1.65 | COFACTOR: Name=pyruvate; Xref=ChEBI:CHEBI:15361; Evidence={ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:25724650}; Note=Binds 1 pyruvoyl group covalently per subunit. {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:25724650}; | phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540] | endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739] | phosphatidylserine decarboxylase activity [GO:0004609] | PF02666; | null | Phosphatidylserine decarboxylase family, PSD-B subfamily, Eukaryotic type I sub-subfamily | PTM: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme... | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:22057268}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9GPP8, ECO:0000255|HAMAP-Rule:MF_03208}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03208}. Note=Equally found in the membrane-bound as well as in the soluble fraction. {ECO:0000255|HAMAP-Ru... | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2; Xref=Rhea:RHEA:20828, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57262, ChEBI:CHEBI:64612; EC=4.1.1.65; Evidence={ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:22057268, ECO... | null | PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000305|PubMed:22057268}. | null | null | FUNCTION: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. {ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:22057268}. | Plasmodium knowlesi (strain H) |
B3LF48 | EHD2_ARATH | METSSTISIGSCLKEHQKIYKEWFNIADSDGDGRVSGNDATKFFAMSKLSRQELKQVWAVADSKRQGFLGLSEFITAMKLVSLAQEGHEITSDLLKGSIDMKSVELPVLEGLENVVSKQKVSKTNVDVEDNVVTKPQVTAKTPWFKSKSIIKPQVNVVTIVDGLKRLYTEKLKPLEVTYRFNDFASPVLTSSDFDAKPMVMLLGQYSTGKTTFIKHLLGCDYPGAHIGPEPTTDRFVVAMSGPDERTIPGNTMAVQADMPFNGLTSFGGAFLSKFECSQMPHPVLDQITLVDTPGVLSGEKQRMQRSYDFTGVISWFASK... | 3.6.5.2 | null | endocytosis [GO:0006897]; endosomal transport [GO:0016197]; protein homooligomerization [GO:0051260]; regulation of actin cytoskeleton organization [GO:0032956] | cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasmodesma [GO:0009506] | calcium ion binding [GO:0005509]; G protein activity [GO:0003925]; GTP binding [GO:0005525] | PF18150;PF00350;PF12763;PF16880; | 1.10.268.20;1.10.238.10;3.40.50.300; | TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, EHD subfamily | null | SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q641Z6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q641Z6}. Cell membrane {ECO:0000269|PubMed:18547399, ECO:0000269|PubMed:19936242}; Peripheral membrane protein {ECO:0000269|PubMed:18547399, ECO:0000269|PubMed:19936242}; Cytoplasmic side {ECO:0000... | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU00758}; | null | null | null | null | FUNCTION: Involved in endocytosis negative regulation, probably by influencing actin organization. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Exhibits an inhibitory effect on endocytosis when over-expressed. {ECO:0000269|PubMed:18547399, ECO:0000269|PubMed:19936242}. | Arabidopsis thaliana (Mouse-ear cress) |
B3LGE9 | ARO1_YEAS1 | MVQLAKVPILGNDIIHVGYNIHDHLVETIIKHCPSSTYVICNDTNLSKVPYYQQLVLEFKASLPEGSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMRGVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGEKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQ... | 1.1.1.25; 2.5.1.19; 2.7.1.71; 4.2.1.10; 4.2.3.4 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; | amino acid biosynthetic process [GO:0008652]; aromatic amino acid family biosynthetic process [GO:0009073]; chorismate biosynthetic process [GO:0009423]; phosphorylation [GO:0016310] | cytoplasm [GO:0005737] | 3-dehydroquinate dehydratase activity [GO:0003855]; 3-dehydroquinate synthase activity [GO:0003856]; 3-phosphoshikimate 1-carboxyvinyltransferase activity [GO:0003866]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; shikimate 3-dehydrogenase (NADP+) activity [GO:0004764]; shikimate kinase activity [GO:000476... | PF01761;PF01487;PF00275;PF18317;PF01488;PF08501;PF01202; | 3.40.50.1970;3.20.20.70;1.20.1090.10;3.65.10.10;3.40.50.10860;3.40.50.720;3.40.50.300; | Sugar phosphate cyclases superfamily, Dehydroquinate synthase family; EPSP synthase family; Shikimate kinase family; Type-I 3-dehydroquinase family; Shikimate dehydrogenase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03143}. | CATALYTIC ACTIVITY: Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364, ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4; Evidence={ECO:0000255|HAMAP-Rule:MF_03143}; CATALYTIC ACTIVITY: Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O; Xr... | null | PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. {ECO:0000255|HAMAP-Rule:MF_03143}.; PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: st... | null | null | FUNCTION: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03143}. | Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast) |
B3LV44 | HH_DROAN | MDNSDCRVPWASAPSSMTCLSLDPTKCHSSSSSSKCQPDCDTPPAAEKIQRHIAYTQRCPGKITTLLAVLLLVLPLSFTPAHSCGPGRGLGRRRERNLYPLVLKQTIPNLSEYTSGASGPLEGPIRRDSPKFKDLVPNYNRDILFRDDEGTGADRLMSKRCKEKLNVLAYSVMNEWPGVRLLVAESWDEDYQHGKESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLEGGVRKPLGELSIGDRVLSMTSNGQPVYSEVILFMDRNLKQMQNFVRLHTAGGA... | 3.1.-.- | null | anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:000... | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila ananassae (Fruit fly) |
B3M185 | RAS1_DROAN | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLASWNVNNEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRRGRKMNKPNRRFKCKML | 3.6.5.2 | null | border follicle cell migration [GO:0007298]; cellular response to starvation [GO:0009267]; chorion-containing eggshell pattern formation [GO:0030381]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; dorsal closure, spreading of leading edge cells [GO:0007395]; epidermal growth fact... | membrane [GO:0016020]; plasma membrane [GO:0005886] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; protein serine/threonine kinase activator activity [GO:0043539] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Ras family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08646}; Lipid-anchor {ECO:0000250|UniProtKB:P08646}; Cytoplasmic side {ECO:0000250|UniProtKB:P08646}. | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01112}; | null | null | null | null | FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormo... | Drosophila ananassae (Fruit fly) |
B3M301 | SPAST_DROAN | MVRTKNQSSSSSASSSTKSPIKSGSAGSGSAAGGNSASGSRQSTHRSSSASNVASAAAAAVASSNRTRTSPGSSPDGDDDTTTTDDLTPTSCSPRSGHHHHGHPYGGSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSKDQQQQHQSQPLSYPLELSEGGNPEQQLPSQTQRYRAIQPLEMASNRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDLRM... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862;PF09336; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila ananassae (Fruit fly) |
B3M3M6 | UBP36_DROAN | MPVSVAVCETTNVVNAALRESLGVGIGSGGASSDDKSAGEDTNSLQNHIVANAKRILMTKIEYEEVPNYQEAVLENLKSKYIVIKPTNPTNGCNLNGNTANTFGNKNNAGKIVGANGHDNNGRKLSDHPNQNHNHANPNGHHANPNELPKPKRVLYPRENIRIGWKQSERKWQVGSGMINAGNTCYLNSTLQALFHIPALANWLVSEQAHMENCNVSESGSFCIICAMAKTLQATQTTQSAVRPFLIYTKLKQICKHMIVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNH... | 3.4.19.12 | null | germ-line stem cell population maintenance [GO:0030718]; heterochromatin formation [GO:0031507]; negative regulation of antimicrobial peptide production [GO:0002785]; negative regulation of innate immune response [GO:0045824]; negative regulation of macroautophagy [GO:0016242]; negative regulation of peptidoglycan reco... | cytosol [GO:0005829]; nucleolus [GO:0005730] | cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578] | PF00443; | 3.90.70.10; | Peptidase C19 family | null | SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; | null | null | null | null | FUNCTION: Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby prev... | Drosophila ananassae (Fruit fly) |
B3M6I4 | PLK4_DROAN | MLSNRAFGETIEEYEVQHLLGKGGFASVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIGRPFTEAEAASILRQVVAGLLYLHSHNIMHRDISLSNLLLSKEMHVKIADFGLATQLKRPDERHVTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRPPFETDAVQTTLNKVVLSEYIMPTHLSFEAQDLINKLLKKVPHERIALEHVLRHPFLTKRLENSSNGVYSTPGALNVFSQSLESGDSGIITFASSDSRNSQRLRSVENTA... | 2.7.11.21 | null | centriole replication [GO:0007099]; male meiotic nuclear division [GO:0007140]; mitotic spindle organization [GO:0007052]; phosphorylation [GO:0016310]; positive regulation of protein catabolic process [GO:0045732]; regulation of centriole replication [GO:0046599]; regulation of protein stability [GO:0031647]; sperm ax... | centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069;PF18190;PF18409; | 2.40.50.930;3.30.1120.120;3.30.1120.130;1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily | PTM: Ubiquitinated by the SCF(Slimb) ubiquitin ligase complex; leading to its degradation by the proteasome during interphase and regulating centriole number and ensuring the block to centriole reduplication. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is... | Drosophila ananassae (Fruit fly) |
B3MEY6 | LIS1_DROAN | MKMVLSQRQREELNQAIADYLGSNGYADSLEAFRKEADLSTEAEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKYSMSGHRASITRVIFHPIFGLVVSASEDATIKIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQTYECVKTMHGHDHNVSSVAFVPAGDYVLSASRDRTVKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDHTIRVWLTNSRDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT... | null | null | border follicle cell migration [GO:0007298]; centrosome localization [GO:0051642]; centrosome separation [GO:0051299]; chorion-containing eggshell pattern formation [GO:0030381]; clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883]; dendrite morphogenesis [GO:0048813]; establishment of mitotic spindle... | axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; CIA complex [GO:0097361]; dendrite [GO:0030425]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; growth cone [GO:0030426]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; neuronal cell body [GO:0043025]; spindle pole centrosome [GO:00316... | dynein complex binding [GO:0070840] | PF08513;PF00400; | 1.20.960.30;2.130.10.10; | WD repeat LIS1/nudF family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. | null | null | null | null | null | FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. {ECO:0000255|HAMAP-Rule:MF_03141}. | Drosophila ananassae (Fruit fly) |
B3MH43 | PTK7_DROAN | MAALRISVWILVQALMMALVSSNSSHFLQLPQSQSVVENESVDFECQASTDPSSELHYEWLHNGHRIAYDKRVYQIGSHLHIEAVQRAEDVGDYVCIATSLASGAREASPPAKLSVIYIDSASVQLLGSNRNELLLKCHVEAVSGSDDPLQIEWYRNSAKLSSWQNVQLDQHRLIIRQPSAADDGLYRCTASNAAGRVMSKQGYVYRSSLKCLPRLPRRKNQKLPESWSKEVFLCRGKRGGSGGVEALPSAPEDLRIVQGPASHAIIKEGDPAALTCLYELPAELQNQRIQLRWRKDGKLLRHVELGNSLPLPGISSDSG... | null | null | cell adhesion [GO:0007155]; imaginal disc-derived female genitalia morphogenesis [GO:0048804]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; internal genitalia morphogenesis [GO:0035260]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell axon guidance [GO:0072499... | axon [GO:0030424]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; W... | PF07679;PF13927;PF07714; | 2.60.40.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6AWJ9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6AWJ9}. | null | null | null | null | null | FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in t... | Drosophila ananassae (Fruit fly) |
B3MPN6 | IRS1_DROAN | MASISDDGMVLSGYHKKLKTMKKKFFVLYEETSINQARLEYYDTEKKFLQRAEPKRVIYLKDCFNINRRLDTKHRFVIVLSSREGGFGIVLESENDLRKWLDKLLLLQRNIANVNGQVYSAYEHVWQVIIQKKGMSEKVGITGTYHCCLSAKSLTFVCIGPEKTANGDDRISSIEILLTTIRRCGHASPQCIFYMELGRQSVLGSGELWMETDNAAIATNMHNTILSAMSAKTDSNTNLINVYQARPDISHEPMRKRSSSANEASKPINVIQNRQNSLELRNCSSPHNYGFPRERCDSLPTRNGTLSESSNQSYFGSNLG... | null | null | cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; germ-line stem-cell niche homeostasis [GO:0060250]; glucose homeostasis [GO:0042593]; growth of a germarium-derived egg chamber [GO:0007295]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor s... | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548] | PF02174; | 2.30.29.30; | null | null | null | null | null | null | null | null | FUNCTION: Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell prol... | Drosophila ananassae (Fruit fly) |
B3MRI9 | SWS_DROAN | MDVLELLRASATGSYTALFSDAWCQYVSKQITNSMYLYCALGVLSMVFLAWFMYFKRLARIRLRDEASRSMSAVNSSSGGDLRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIDGSDRVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMEAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAE... | 3.1.1.5 | null | ensheathment of neurons [GO:0007272]; glial cell apoptotic process [GO:0034349]; lipid catabolic process [GO:0016042]; membrane lipid metabolic process [GO:0006643]; membrane organization [GO:0061024]; neuron apoptotic process [GO:0051402]; phosphatidylcholine metabolic process [GO:0046470]; photoreceptor cell maintena... | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; protein kinase A catalytic subunit binding [GO:0034236] | PF00027;PF01734; | 3.40.1090.10;2.60.120.10; | NTE family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9U969}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9U969}. Note=Sws tethers Pka-C3 to the membrane. {ECO:0000250|UniProtKB:Q9U969}. | CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:Q9U969}; | null | null | null | null | FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in... | Drosophila ananassae (Fruit fly) |
B3N5J3 | FICD_DROER | MGTEAEPPSPPSPPAQQQEQANPPVWNAQNQKPARLYRLVLFFIAGSLTAWMFHAFSSSNLAWKLRQLHHLPTAHYLQTRDEFALYSVEELNAFKEFYDKSVSDSVGASFTEAEQTSINEALVSLRMAQDMYLTGKDDKAARLFEHALALAPRHPEVLLRYGEFLEHNQRNIVLADQYYFQALTISPSNSEALANRQRTADVVQNLDQRRLESLDSKRDALSAIHESNAALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKIEITIKDILELHRRVMGHVDPIE... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-250 determines which of the two op... | Drosophila erecta (Fruit fly) |
B3N946 | IRS1_DROER | MASISDDGMALSGYLKKLKTMKKKFFVLYEETSNSSARLEYYDTEKKFLQRAEPKRVIYLKNCFNINRRLDTKQRFVIVLSSRDGGFGIVLESENDLRKWLDKLLVLQRNIANTNGTAYSPYDQVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPDKTPNGEERVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAVATNMHNTILSAMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQNSQNSLDLRSCSSPHNYGFGRERCDSLPTRNGTLSESSNQTYFGSN... | null | null | cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; germ-line stem-cell niche homeostasis [GO:0060250]; glucose homeostasis [GO:0042593]; growth of a germarium-derived egg chamber [GO:0007295]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor s... | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548] | PF02174; | 2.30.29.30; | null | null | null | null | null | null | null | null | FUNCTION: Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell prol... | Drosophila erecta (Fruit fly) |
B3NC86 | UBP36_DROER | MPVSMAVCETANVVNAALRESLGGNSSAAGSSADQAKSGEESNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLESLKSKYIVIKPGNPGAINGFGGKNNTGKVVGANGHDNNGARKQAEHPNNQSHHNNHNNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLENCNVAESGGGCIVCAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSI... | 3.4.19.12 | null | germ-line stem cell population maintenance [GO:0030718]; heterochromatin formation [GO:0031507]; negative regulation of antimicrobial peptide production [GO:0002785]; negative regulation of innate immune response [GO:0045824]; negative regulation of macroautophagy [GO:0016242]; negative regulation of peptidoglycan reco... | cytosol [GO:0005829]; nucleolus [GO:0005730] | cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578] | PF00443; | 3.90.70.10; | Peptidase C19 family | null | SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; | null | null | null | null | FUNCTION: Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby prev... | Drosophila erecta (Fruit fly) |
B3NE99 | PLK4_DROER | MLSNRAFGETIEDYEVQHLLGKGGFAIVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSKEMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRSSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHSTPGALNMFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQV... | 2.7.11.21 | null | centriole replication [GO:0007099]; male meiotic nuclear division [GO:0007140]; mitotic spindle organization [GO:0007052]; phosphorylation [GO:0016310]; positive regulation of protein catabolic process [GO:0045732]; regulation of centriole replication [GO:0046599]; regulation of protein stability [GO:0031647]; sperm ax... | centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069;PF18190;PF18409; | 2.40.50.930;3.30.1120.120;3.30.1120.130;1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily | PTM: Ubiquitinated by the SCF(Slimb) ubiquitin ligase complex; leading to its degradation by the proteasome during interphase and regulating centriole number and ensuring the block to centriole reduplication. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is... | Drosophila erecta (Fruit fly) |
B3NPW0 | LIS1_DROER | MKMVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKFSLTGHRASITRVIFHPIFGLMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT... | null | null | border follicle cell migration [GO:0007298]; brain morphogenesis [GO:0048854]; centrosome localization [GO:0051642]; centrosome separation [GO:0051299]; chorion-containing eggshell pattern formation [GO:0030381]; clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883]; dendrite morphogenesis [GO:0048813]... | axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; growth cone [GO:0030426]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; neuronal cell body [GO:0043025]; nuclear envelope [GO:... | dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010] | PF08513;PF00400; | 1.20.960.30;2.130.10.10; | WD repeat LIS1/nudF family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. | null | null | null | null | null | FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. {ECO:0000255|HAMAP-Rule:MF_03141}. | Drosophila erecta (Fruit fly) |
B3NS99 | PTK7_DROER | MTARMISIYGLVLASMMASVWASSSRFQRLPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAARRTEDVGSYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDSEPLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSDDDGLYRCTASNAAGRVMSKQGYAYQSSVKCLPRLARRKNQKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPVGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPITGHSFDSGK... | null | null | cell adhesion [GO:0007155]; imaginal disc-derived female genitalia morphogenesis [GO:0048804]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; internal genitalia morphogenesis [GO:0035260]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell axon guidance [GO:0072499... | axon [GO:0030424]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; W... | PF07679;PF13927;PF07714; | 2.60.40.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6AWJ9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6AWJ9}. | null | null | null | null | null | FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in t... | Drosophila erecta (Fruit fly) |
B3NY03 | SWS_DROER | MDVLEMLRASASGSYNTIFSEAWCQYVSKQITATMYMYCALGMMGVLFLAWFMYFKRMARLRLRDEIARSISAVTNSSGDLRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAEL... | 3.1.1.5 | null | ensheathment of neurons [GO:0007272]; glial cell apoptotic process [GO:0034349]; lipid catabolic process [GO:0016042]; membrane lipid metabolic process [GO:0006643]; membrane organization [GO:0061024]; neuron apoptotic process [GO:0051402]; phosphatidylcholine metabolic process [GO:0046470]; photoreceptor cell maintena... | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; protein kinase A catalytic subunit binding [GO:0034236] | PF00027;PF01734; | 3.40.1090.10;2.60.120.10; | NTE family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9U969}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9U969}. Note=Sws tethers Pka-C3 to the membrane. {ECO:0000250|UniProtKB:Q9U969}. | CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:Q9U969}; | null | null | null | null | FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in... | Drosophila erecta (Fruit fly) |
B3NZR4 | RAS1_DROER | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLASWNVNNEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRRGRKMNKPNRRFKCKML | 3.6.5.2 | null | border follicle cell migration [GO:0007298]; cellular response to starvation [GO:0009267]; chorion-containing eggshell pattern formation [GO:0030381]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; dorsal closure, spreading of leading edge cells [GO:0007395]; epidermal growth fact... | membrane [GO:0016020]; plasma membrane [GO:0005886] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; protein serine/threonine kinase activator activity [GO:0043539] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Ras family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08646}; Lipid-anchor {ECO:0000250|UniProtKB:P08646}; Cytoplasmic side {ECO:0000250|UniProtKB:P08646}. | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01112}; | null | null | null | null | FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormo... | Drosophila erecta (Fruit fly) |
B3P7F8 | HH_DROER | MDNTSSVPWASAASVTCLSLDAKCHSSSAKSAASSISASPETQAMRHIAHTQRCLSRLTSLVALLLIVLPMTFSPAHSCGPGRGLGRHRARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCREKLNLLAYSVMNEWPGIRLLVTESWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLENGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTDGEAVLTVT... | 3.1.-.- | null | Bolwig's organ morphogenesis [GO:0001746]; cell-cell signaling involved in cell fate commitment [GO:0045168]; cytoneme assembly [GO:0035231]; epithelial cell migration, open tracheal system [GO:0007427]; genital disc anterior/posterior pattern formation [GO:0035224]; glial cell migration [GO:0008347]; gonadal mesoderm ... | cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila erecta (Fruit fly) |
B3P8A3 | SPAST_DROER | MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGVGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHTYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELSREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRL... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862;PF09336; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila erecta (Fruit fly) |
B3PC73 | AGUA_CELJU | MSTFARLFLCLVFFASLQPAMAQTEDGYDMWLRYQPIADQTLLKTYQKQIRHLHVAGDSPTINAAAAELQRGLSGLLNKPIVARDEKLKDYSLVIGTPDNSPLIASLNLGERLQALGAEGYLLEQTRINKRHVVIVAANSDVGVLYGSFHLLRLIQTQHALEKLSLSSAPRLQHRVVNHWDNLNRVVERGYAGLSLWDWGSLPNYLAPRYTDYARINASLGINGTVINNVNADPRVLSDQFLQKIAALADAFRPYGIKMYLSINFNSPRAFGDVDTADPLDPRVQQWWKTRAQKIYSYIPDFGGFLVKADSEGQPGPQGY... | 3.2.1.131 | null | glucuronoxylan catabolic process [GO:2000886] | cell outer membrane [GO:0009279]; extracellular region [GO:0005576] | alpha-glucuronidase activity [GO:0046559]; xylan alpha-1,2-glucuronosidase activity [GO:0033939] | PF07477;PF07488;PF03648; | 3.90.1330.10;3.30.379.10;3.20.20.80; | Glycosyl hydrolase 67 family | null | SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:12169619}. | CATALYTIC ACTIVITY: Reaction=Hydrolysis of (1->2)-alpha-D-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans.; EC=3.2.1.131; Evidence={ECO:0000269|PubMed:12169619}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.28 mM for aldotriouronic acid (at 37 degrees Celsius) {ECO:0000269|PubMed:11937059, ECO:0000269|PubMed:12654910}; KM=0.36 mM for aldotetraouronic acid (at 37 degrees Celsius) {ECO:0000269|PubMed:11937059, ECO:0000269|PubMed:12654910}; KM=0.42 mM for aldopentaouro... | null | null | null | FUNCTION: Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. It catalyzes the cleavage of the alpha-1,2-glycosidic bond at the non-reducing end of 4-O-meth... | Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa) |
B3STU4 | VCL_CARIL | MVTKAKIPLFLFLSALFLALVCSSLALETEDLSNELNPHHDPESHRWEFQQCQERCQHEERGQRQAQQCQRRCEEQLREREREREREEIVDPREPRKQYEQCRETCEKQDPRQQPQCERRCERQFQEQQERERRERRRGRDDDDKENPRDPREQYRQCEEHCRRQGQGQRQQQQCQSRCEERFEEEQRRQEERERRRGRDNDDEENPRDPREQYRQCQEHCRRQGQGQRQQQQCQSRCEERLEEEQRKQEERERRRGRDEDDQNPRDPEQRYEQCQQQCERQRRGQEQQLCRRRCEQQRQQEERERQRGRDRQDPQQQYH... | null | null | protein homotrimerization [GO:0070207]; seed development [GO:0048316]; seed maturation [GO:0010431] | null | copper ion binding [GO:0005507]; nutrient reservoir activity [GO:0045735] | PF00190;PF04702; | 6.10.250.890;2.60.120.10; | 7S seed storage protein family | null | null | null | null | null | null | null | FUNCTION: Seed storage protein. {ECO:0000305|PubMed:25084379, ECO:0000305|PubMed:27128197}. | Carya illinoinensis (Pecan) |
B3SV56 | NR1D1_SHEEP | MTTLDSNNNTGGVITYIGSSGSSPNRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLGDDGSPSSSSSSSSSSSSSFYNGSPPGGLQVALEDGNRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETPPTQHPTPGPMGPSPPPAPAPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGTSPGNFNANHA... | null | null | cell differentiation [GO:0030154]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; glycogen biosynthetic process [GO:00059... | cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; nucleus [GO:0005634] | E-box binding [GO:0070888]; nuclear receptor activity [GO:0004879]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] | PF00104;PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family, NR1 subfamily | PTM: Ubiquitinated, leading to its proteasomal degradation (By similarity). Ubiquitinated by the SCF(FBXW7) complex when phosphorylated by CDK1 leading to its proteasomal degradation (By similarity). Ubiquitinated by SIAH2; leading to its proteasomal degradation (By similarity). Rapidly ubiquitinated in response to inf... | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:Q3UV55}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3UV55}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q3UV55}. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPH... | null | null | null | null | null | FUNCTION: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core c... | Ovis aries (Sheep) |
B3TLD6 | LNBB_BIFB1 | MEKSSNRRFGVRTVAAIVAGLMVGGMCTAMTASAADDSAAGYSATAPVNLTRPATVPSMDGWTDGTGAWTLGEGTRVVSSDALAARAQSLASELTKFTDVDIKAATGSATGKDISLTLDASKKAELGDEGFKLNIGSKGLEVIGATDIGVFYGTRSVSQMLRQGQLTLPAGTVATKPKYKERGATLCACQINISTDWIDRFLSDMADLRLNYVLLEMKLKPEEDNTKKAATWSYYTRDDVKKFVKKANNYGIDVIPEINSPGHMNVWLENYPEYQLADNSGRKDPNKLDISNPEAVKFYKTLIDEYDGVFTTKYWHMGAD... | 3.2.1.140 | null | carbohydrate metabolic process [GO:0005975] | plasma membrane [GO:0005886] | beta-N-acetylhexosaminidase activity [GO:0004563]; lacto-N-biosidase activity [GO:0047403]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148] | PF02368;PF00754;PF00728;PF02838;PF14200; | 2.60.40.1080;2.80.10.50;3.30.379.10;2.60.120.260;3.20.20.80; | Glycosyl hydrolase 20 family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}; Extracellular side {ECO:0000305|PubMed:18469123}. | CATALYTIC ACTIVITY: Reaction=beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose; Xref=Rhea:RHEA:21568, ChEBI:CHEBI:15377, ChEBI:CHEBI:17716, ChEBI:CHEBI:27707, ChEBI:CHEBI:30248; EC=3.2.1.140; Evidence={ECO:0000269|PubMed:18469123, ECO:000026... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=626 uM for lacto-N-tetraose {ECO:0000269|PubMed:23479733}; KM=68 uM for chromogenic LNB-beta-pNP (beta-D-Gal-(1->3)-beta-D-GlcNAc-pNP) {ECO:0000269|PubMed:18469123}; Note=kcat is 41.1 sec(-1) with lacto-N-tetraose as substrate (PubMed:23479733). kcat is 89 sec(-1) ... | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 4.5 with LNB-beta-pNP as substrate and pH 6.0 with PA-lacto-N-tetraose. {ECO:0000269|PubMed:18469123}; | null | FUNCTION: Present in the infant gut, this enzyme is involved in the assimilation of type-1 human milk oligosaccharides (HMOs). It hydrolyzes via a retaining mechanism the beta-D-GlcNAc-(1->3)-beta-D-Gal linkage in lacto-N-tetraose (LNT or beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc), an abundant HMO ... | Bifidobacterium bifidum (strain DSM 20082 / JCM 1254 / BCRC 11844 / KCTC 3440 / E319f (Variant a)) |
B3TMR8 | KIJDR_ACTKI | MENPANANPIRVGVIGCADIAWRRALPALEAEPLTEVTAIASRRWDRAKRFTERFGGEPVEGYPALLERDDVDAVYVPLPAVLHAEWIDRALRAGKHVLAEKPLTTDRPQAERLFAVARERGLLLMENFMFLHHPQHRQVADMLDEGVIGEIRSFAASFTIPPKPQGDIRYQADVGGGALLDIGVYPIRAAGLFLGADLEFVGAVLRHERDRDVVVGGNALLTTRQGVTAQLTFGMEHAYTNNYEFRGSTGRLWMNRVFTPPATYQPVVHIERQDHAEQFVLPAHDQFAKSIRAFAQAVLSGEHPREWSEDSLRQASLVD... | 1.1.1.384 | null | antibiotic biosynthetic process [GO:0017000]; D-xylose catabolic process [GO:0042843] | null | D-xylose 1-dehydrogenase (NADP+) activity [GO:0047837]; nucleotide binding [GO:0000166] | PF01408;PF02894; | 3.40.50.720; | Gfo/Idh/MocA family | null | null | CATALYTIC ACTIVITY: Reaction=dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH; Xref=Rhea:RHEA:44624, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:84537, ChEBI:CHEBI:84540; EC=1.1.1.384; Evidence={ECO:0000269|PubMed:21598943}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=116.4 uM for dTDP-glucose {ECO:0000269|PubMed:21598943}; KM=6.31 mM for NADPH {ECO:0000269|PubMed:21598943}; Vmax=0.01 mmol/min/mg enzyme {ECO:0000269|PubMed:21598943}; Note=kcat is 6.24 sec(-1) for dTDP-glucose as substrate. {ECO:0000269|PubMed:21598943}; | PATHWAY: Antibiotic biosynthesis. {ECO:0000305|PubMed:21598943}. | null | null | FUNCTION: Involved in the biosynthesis of L-digitoxose, an unusual dideoxysugar attached to various pharmacologically active natural products, including the antitumor antibiotic tetrocarcin A, and the antibiotics kijanimicin and jadomycin B. Catalyzes the reduction of the C-3 keto moiety of dTDP-3,4-diketo-2,6-dideoxy-... | Actinomadura kijaniata |
B3TP03 | CTR2_CHICK | MLPCGPALTFVRCLVRKKNIKGEGLEDSLCRCLSTLDLIALGVGSTLGAGVYVLAGEVAKSDSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVAVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLGKQISHFFKTYFKMNYPGLAEYPDFFAVFLILLLSGLLSFGVKESAWVNKIFTAINILVLLFVMISGFVKGDVDNWRISEEYLINLSEIAENFSSYKNVTSIYGSGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVVSLLVCFMAYFGVSAALTLMMPYYLLD... | null | null | L-arginine import across plasma membrane [GO:0097638]; L-lysine import across plasma membrane [GO:0097639]; L-ornithine transmembrane transport [GO:1903352] | cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] | L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] | PF13520;PF13906; | 1.20.1740.10; | Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18581}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18581}. | CATALYTIC ACTIVITY: Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143, ChEBI:CHEBI:32682; Evidence={ECO:0000250|UniProtKB:P18581}; CATALYTIC ACTIVITY: Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935, ChEBI:CHEBI:32551; Evidence={ECO:0000250|UniProtKB:P18581}; CATALYTIC ACTIVITY: Reaction=L-orn... | null | null | null | null | FUNCTION: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000250|UniProtKB:P18581, ECO:0000250|UniProtKB:P52569}. | Gallus gallus (Chicken) |
B3VI55 | LGK_LIPST | MPIATSTGDNVLDFTVLGLNSGTSMDGIDCALCHFYQKTPDAPMEFELLEYGEVPLAQPIKQRVMRMILEDTTSPSELSEVNVILGEHFADAVRQFAAERNVDLSTIDAIASHGQTIWLLSMPEEGQVKSALTMAEGAILASRTGITSITDFRISDQAAGRQGAPLIAFFDALLLHHPTKLRACQNIGGIANVCFIPPDVDGRRTDEYYDFDTGPGNVFIDAVVRHFTNGEQEYDKDGAMGKRGKVDQELVDDFLKMPYFQLDPPKTTGREVFRDTLAHDLIRRAEAKGLSPDDIVATTTRITAQAIVDHYRRYAPSQEI... | 2.7.1.232 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:26354439, ECO:0000269|PubMed:28196882}; Note=Binds 2 Mg(2+) ions per subunit. {ECO:0000269|PubMed:26354439, ECO:0000269|PubMed:28196882}; | amino sugar metabolic process [GO:0006040]; peptidoglycan turnover [GO:0009254]; phosphorylation [GO:0016310] | null | ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] | PF03702; | 3.30.420.40; | Anhydro-N-acetylmuramic acid kinase family | null | null | CATALYTIC ACTIVITY: Reaction=ATP + H2O + levoglucosan = ADP + D-glucose 6-phosphate + H(+); Xref=Rhea:RHEA:63428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:30997, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.232; Evidence={ECO:0000269|PubMed:21719279, ECO:0000269|PubMed:26354439, ECO:00002... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=105.3 mM for levoglucosan {ECO:0000269|PubMed:26354439, ECO:0000269|Ref.1}; KM=0.2 mM for ATP {ECO:0000269|Ref.1}; | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 9.0. {ECO:0000269|Ref.1}; | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 30 degrees Celsius. {ECO:0000269|Ref.1}; | FUNCTION: Levoglucosan kinase that catalyzes the transfer of a phosphate group from ATP to levoglucosan (1,6-anhydro-beta-D-glucopyranose, LG) to yield glucose 6-phosphate in the presence of magnesium ion and ATP (PubMed:21719279, PubMed:26354439, Ref.1). In addition to the canonical kinase phosphotransfer reaction, th... | Lipomyces starkeyi (Oleaginous yeast) |
B3WFY8 | DYF5_CAEEL | MSSAVKLADRYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNIIKLREVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNGTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMNFRFQQVVATPMEQVVNTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYFQVAEKLGAPVVSQPAPGSIRKTSAASVKS... | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q9JKV2}; | cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; negative regulation of non-motile cilium assembly [GO:1902856]; non-motile cilium assembly [GO:1905515]; phosphorylation [GO:0016310]; positive regulation o... | axon [GO:0030424]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; perikaryon [GO:0043204] | ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, RCK subfamily | null | SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:17420466}. Cell projection, dendrite {ECO:0000269|PubMed:17420466}. Cell projection, axon {ECO:0000269|PubMed:17420466}. Cell projection, cilium {ECO:0000269|PubMed:17420466}. Note=Enriched at the transition zone between the base of the cilia and the dendrites and to... | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q9JKV2}; CATALYTI... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase which is required for ciliogenesis. Regulates the length and the morphology of sensory neuron cilia. In addition, plays a role in the anterograde intraflagellar transport (IFT) in the cilia by regulating the undocking of kinesin-II motor complex (composed of klp-11, klp-20 and ... | Caenorhabditis elegans |
B3Y613 | TLR2_PANTR | MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFRFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIP... | null | null | cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] | Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670] | NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497] | PF00560;PF13855;PF01463;PF01582; | 3.80.10.10;3.40.50.10140; | Toll-like receptor family | PTM: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2. {ECO:0000250|UniProtKB:Q9QUN7}.; PTM: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. {ECO:0000250|UniProtKB:O60603}. | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:O60603}. Note=Does not reside in lipid rafts b... | null | null | null | null | null | FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secr... | Pan troglodytes (Chimpanzee) |
B3Y614 | TLR2_PANPA | MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYESKSLKSIQNVSHLILHMKQHILLLEIFVDVSSSVECLELRDTDLDTFRFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIP... | null | null | cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] | Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670] | NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497] | PF00560;PF13855;PF01463;PF01582; | 3.80.10.10;3.40.50.10140; | Toll-like receptor family | PTM: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2. {ECO:0000250|UniProtKB:Q9QUN7}.; PTM: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. {ECO:0000250|UniProtKB:O60603}. | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:O60603}. Note=Does not reside in lipid rafts b... | null | null | null | null | null | FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secr... | Pan paniscus (Pygmy chimpanzee) (Bonobo) |
B3Y615 | TLR2_GORGO | MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIP... | null | null | cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; cellular response to type II interferon [GO:0071346]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus ... | cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355] | amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; pattern recognition receptor activity [GO:0038187]; peptidoglycan binding [GO:0042834]; protein-containing complex binding [GO:0044877]; signa... | PF00560;PF13855;PF01463;PF01582; | 3.80.10.10;3.40.50.10140; | Toll-like receptor family | PTM: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2. {ECO:0000250|UniProtKB:Q9QUN7}.; PTM: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. {ECO:0000250|UniProtKB:O60603}. | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:O60603}. Note=Does not reside in lipid rafts b... | null | null | null | null | null | FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secr... | Gorilla gorilla gorilla (Western lowland gorilla) |
B3Y618 | TLR2_MACMU | MPHTLWMVWVLGVIISLSKEESSNQASLSCDHNGICKGSSGSLNSIPSVLTEAVKCLDLSNNRITYISNSDLQRYVNLQALVLTSNGINTIEEDSFSSLGRLEHLDLSYNYLSNLSSSWFKPLSSLKFLNLLGNPYKTLGETSLFSHLTKLRILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDLTSSVECLELRDTDLNTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLSQISGLLELEFDDCTLNGVGDFRGSDNDRVIDPGKVETLTIRRLHIP... | null | null | cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] | Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670] | NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497] | PF13855;PF01463;PF01582; | 3.80.10.10;3.40.50.10140; | Toll-like receptor family | PTM: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2. {ECO:0000250|UniProtKB:Q9QUN7}.; PTM: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. {ECO:0000250|UniProtKB:O60603}. | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:O60603}. Note=Does not reside in lipid rafts b... | null | null | null | null | null | FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secr... | Macaca mulatta (Rhesus macaque) |
B4EUF7 | ENO_PROMH | MSKIVKVLGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVLKAVEAVNGPIAKALLGQDAKDQANIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLYEHISDLNGTHGQYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAPTLKEAVRMGSEIFHHLAKVLKAKGMNTAVGDEGGYAPNLESNAAALAAIKEAVEAAGYVLGKDVTLAMDCAASEFYNNETGNYELKGEGKTFTSQEFTHYLEELTKQYLIVSIEDGLNESDWDGFAYQTKVLGDKIQLVGDDL... | 4.2.1.11 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00318}; Note=Binds a second Mg(2+) ion via substrate during catalysis. {ECO:0000255|HAMAP-Rule:MF_00318}; | glycolytic process [GO:0006096] | cell surface [GO:0009986]; extracellular region [GO:0005576]; phosphopyruvate hydratase complex [GO:0000015] | magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] | PF00113;PF03952; | 3.20.20.120;3.30.390.10; | Enolase family | PTM: Acetylated and 2-hydroxyisobutyrylated at Lys-326 and Lys-343, respectively, reducing the enolase activity (PubMed:31328167). Deacetylated and de-2-hydroxyisobutyrylated by NpdA/CobB, increasing the enolase activity (PubMed:31328167). {ECO:0000269|PubMed:31328167}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00318}. Secreted {ECO:0000255|HAMAP-Rule:MF_00318}. Cell surface {ECO:0000255|HAMAP-Rule:MF_00318}. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. {ECO:0000255|HAMAP-Rule:MF_00318}. | CATALYTIC ACTIVITY: Reaction=(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate; Xref=Rhea:RHEA:10164, ChEBI:CHEBI:15377, ChEBI:CHEBI:58289, ChEBI:CHEBI:58702; EC=4.2.1.11; Evidence={ECO:0000255|HAMAP-Rule:MF_00318, ECO:0000269|PubMed:31328167}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10165; Evidence={ECO... | null | PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00318}. | null | null | FUNCTION: Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP) (PubMed:31328167). It is essential for the degradation of carbohydrates via glycolysis. {ECO:0000255|HAMAP-Rule:MF_00318, ECO:0000269|PubMed:31328167}. | Proteus mirabilis (strain HI4320) |
B4EY22 | CAIT_PROMH | MSKDNKKAGIEPKVFFPPLIIVGILCWLTVRDLDASNEVINAVFSYVTNVWGWAFEWYMVIMFGGWFWLVFGRYAKKRLGDEKPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISSPPFGMEGYSAPAKEIGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLTPLVGEKHVNGLFGTVVDNFYLVALILAMGTSLGLATPLVTECIQYLFGIPHTLQLDAIIISCWILLNAICVAFGLQKGVKIASDVRTYLSFLMLGWVFIVGGASFIVNYFTDSVGTLLMYMPRMLFYTDPIGKGGFPQAWTVFY... | null | null | 4-(trimethylammonio)butanoate transport [GO:1900751]; carnitine metabolic process [GO:0009437] | plasma membrane [GO:0005886] | (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity [GO:0044667] | PF02028; | null | BCCT transporter (TC 2.A.15) family, CaiT subfamily | null | SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01049, ECO:0000269|PubMed:20829798, ECO:0000269|PubMed:24101465}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01049, ECO:0000269|PubMed:20829798, ECO:0000269|PubMed:24101465}. | CATALYTIC ACTIVITY: Reaction=(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out); Xref=Rhea:RHEA:29427, ChEBI:CHEBI:16244, ChEBI:CHEBI:16347; Evidence={ECO:0000255|HAMAP-Rule:MF_01049, ECO:0000269|PubMed:20829798, ECO:0000269|PubMed:24101465}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=46 uM for L-carnitine {ECO:0000269|PubMed:20829798}; KM=8.5 uM for L-carnitine {ECO:0000269|PubMed:24101465}; Vmax=4672 nmol/min/mg enzyme {ECO:0000269|PubMed:20829798}; Vmax=5172 nmol/min/mg enzyme {ECO:0000269|PubMed:24101465}; Note=kcat is 263 min(-1) with L-car... | PATHWAY: Amine and polyamine metabolism; carnitine metabolism. {ECO:0000255|HAMAP-Rule:MF_01049}. | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7. {ECO:0000269|PubMed:24101465}; | null | FUNCTION: Catalyzes the exchange of L-carnitine for gamma-butyrobetaine. {ECO:0000255|HAMAP-Rule:MF_01049, ECO:0000269|PubMed:20829798, ECO:0000269|PubMed:24101465}. | Proteus mirabilis (strain HI4320) |
B4EZY7 | SIAT_PROMH | MQLHDFGFINYAVLFGYLAAMLLVGVYFSKRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAYTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLKITSAYEYLEARFDVRSRLFASLSFMLFHIGRVAIITYLTVLALRPFMGIDPVVLIVLISLLCIIYTWMGGIEGVIWTDVIQGLLLSGGAVLIFIMICFKVDGGISEIFTTTAQADKFFPTTQWRWSWTDSTIPVLMIGFLFANIQQFTASQDVVQRYIVTDSIKETKRTLITNAKLVAIIPIFFFAIGSALFVYYQQNPSLLPAGFNTGGILPLFI... | null | null | sodium ion transport [GO:0006814] | extracellular exosome [GO:0070062]; plasma membrane [GO:0005886] | symporter activity [GO:0015293] | PF00474; | 1.20.1730.10; | Sodium:solute symporter (SSF) (TC 2.A.21) family | null | SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:29717135}; Multi-pass membrane protein {ECO:0000269|PubMed:29717135}. | CATALYTIC ACTIVITY: Reaction=N-acetyl-alpha-neuraminate(out) + 2 Na(+)(out) = N-acetyl-alpha-neuraminate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:78535, ChEBI:CHEBI:29101, ChEBI:CHEBI:58770; Evidence={ECO:0000269|PubMed:29717135}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:78536; Evidence={ECO:0000269|PubMed:2971713... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=16 uM for Neu5Ac {ECO:0000269|PubMed:29717135}; Vmax=187 nmol/min/mg enzyme {ECO:0000269|PubMed:29717135}; | null | null | null | FUNCTION: Symporter that uses the Na(+) gradient as the driving force for the uptake of the sialic acid N-acetylneuraminic acid (Neu5Ac) (PubMed:29717135). It allows the use of host-derived Neu5Ac as an energy source by P.mirabilis (PubMed:29717135). Also binds N-glycolylneuraminic acid (Neu5Gc) and ketodeoxynonulosoni... | Proteus mirabilis (strain HI4320) |
B4F6I3 | FSP1_XENTR | MGSKVSVEESVRVVIVGGGFAGIAAATQLKSFGIPFVLVDLKDAFHHNVAALRASVESGFARKTFISYKDTFQDNFIQGKVVGINLQTQRVILESNEELQFSHLIIATGSNGPFPGKINNVISKDQAIQVYEDLVKEIQKAKHVVVVGGGSAGVEMAAEVKTDYPEKEVTLVHSKVALADVQLQPKVRRTVKEILLSKGVRLILAQKVTNLDQVTSNVAQENTVLQLDKNSEVVTCDLVLCCTGYKISSSSYSSAFGDKLAEDGALIVNDYLQVQGHANVYAVGDCAYINEPKMAYYAGIHARVAATNVRNSLIGKSLKT... | 1.6.5.- | COFACTOR: Name=6-hydroxy-FAD; Xref=ChEBI:CHEBI:60470; Evidence={ECO:0000250|UniProtKB:Q9BRQ8}; Note=Binds 6-hydroxy-FAD non-covalently. {ECO:0000250|UniProtKB:Q9BRQ8}; | apoptotic mitochondrial changes [GO:0008637]; positive regulation of apoptotic process [GO:0043065]; vitamin K metabolic process [GO:0042373] | lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655] | PF07992; | 3.50.50.100; | FAD-dependent oxidoreductase family | PTM: N-myristoylation at Gly-2 mediates the recruitment to lipid droplets and plasma membrane. {ECO:0000250|UniProtKB:Q9BRQ8}. | SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250|UniProtKB:Q9BRQ8}. Cell membrane {ECO:0000250|UniProtKB:Q9BRQ8}; Lipid-anchor {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q9BRQ8}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9BRQ8}. Nucleus {ECO:0000250|UniProtKB:Q9BRQ8}. | CATALYTIC ACTIVITY: Reaction=H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10; Xref=Rhea:RHEA:61984, ChEBI:CHEBI:15378, ChEBI:CHEBI:46245, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:64183; Evidence={ECO:0000250|UniProtKB:Q9BRQ8}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61985; Evidence={ECO:000025... | null | null | null | null | FUNCTION: A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to supp... | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
B4F6I5 | FICD_XENTR | MAVTECEWASLGSRIGLRAALVLLSGSLLVVLFPLSGLEHQYRTALNILLQCNLWGGDDRHTFTGQTRGLAVASTAIELLVLKQKPTSDVKFEAKAALNQALEMKRQGKKEKAHKLLHHALKMDPDHVDALNELGILLEEEKDIIQADYLYSKALTISPHNEKALINRDRTLPLVEEIDQRYFSLIDSKVKKLMSIPKGNPALRRVMEESYYHHIYHTVAIEGNTLSLSEIRHIIETRYAVPGKSLEEQNEVIGMHAAMKYVNATLVSRIGSVTIDNILEIHRRILGYVDPVEAGRFRRNQVFVGHHIPPHPRDVEKLMQ... | 2.7.7.108; 3.1.4.- | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; Note=Divalent metal cation. Prefers Mn(2+) over Mg(2+). {ECO:0000250|UniProtKB:Q9BVA6}; | protein adenylylation [GO:0018117]; protein deadenylylation [GO:0044602]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] | endoplasmic reticulum membrane [GO:0005789] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087] | PF02661; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BVA6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9BVA6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-222 determines which of the two op... | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
B4F6N6 | LOXL2_XENTR | MLVTHIFLLTLSLSVPTLGQYEHWLYYPEYQASQAPEPLPTPARNVPQIHVRLAGEKRKHNEGRVEVYYEGEWGTVCDDDFSMYAAHIVCRELGYQDAVSWSPSSKYGKGEGRIWLDNVNCNGREKSIASCGSNGWGVTDCKHSEDVGVQCSDRRIPGFKVSNELPGQLEGLNIQVEEVRIRAILSAYRKRVPVTEGFVEVKVQGSWRQVCNAEWSSKNSRVVCGMFGFPAEKKFNNKVYKLFSSRRKHTYWQFSANCTGNEAHLSSCKVGGVLTPDPKTNQTCSDGSPAVVSCTPGRAFAPSPGTGFGKAFRQEQPLVR... | 1.4.3.13 | COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000250|UniProtKB:Q9Y4K0}; COFACTOR: Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence={ECO:0000250|UniProtKB:Q9Y4K0}; Note=Contains 1 lysine tyrosylquinone. {ECO:0000250|UniProtKB:P33072, ECO:0000250|UniProtKB:Q9Y4K0}; | collagen fibril organization [GO:0030199]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; heterochromatin organization [GO:0070828]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell... | basement membrane [GO:0005604]; chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634] | calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; oligosaccharide binding [GO:0070492]; protein-lysine 6-oxidase activity [GO:0004720] | PF01186;PF00530; | 3.10.250.10; | Lysyl oxidase family | PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000250|UniProtKB:Q9Y4K0}. | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q9Y4K0}. Nucleus {ECO:0000250|UniProtKB:Q9Y4K0}. Chromosome {ECO:0000250|UniProtKB:Q9Y4K0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y4K0}. Note=Associated with chromatin. It is unclear how LOXL2 is... | CATALYTIC ACTIVITY: Reaction=H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+); Xref=Rhea:RHEA:24544, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:131803; EC=1.4.3.13; Evidence={ECO:... | null | null | null | null | FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transc... | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
B4F753 | ABD12_XENTR | MRKRAEPVPPEHESFGRAPLDRECSIKQKLRIPGTKGHYPHDSDCDSKGMKRFGRRYGLWSRLRMFLIFLLGLYIAIPFLVKICPAIQTQLVFLNLVRFPYFIDLKRPEDQGLNHTCNFYLQPEEDVSIGVWHTVPAVLWKDAQGKDLEWYEEVLSTSYPVILYLHGNAGTRGGDHRVQLYKVLSSMGYHVISFDYRGWGDSVGSPSESGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDSLILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITASGIKFANDDNVKYISCPLLILH... | 3.1.-.-; 3.1.1.23 | null | acylglycerol catabolic process [GO:0046464]; monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]; phospholipid catabolic process [GO:0009395] | endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020] | acylglycerol lipase activity [GO:0047372]; lysophospholipase activity [GO:0004622]; phospholipase activity [GO:0004620] | PF00561; | 3.40.50.1820; | Serine esterase family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N2K0}; Single-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:40499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64765, ChEBI:CHEBI:74617; Evidence={ECO:0000250|UniProtKB:Q8N2K0}; CATALYTIC ACTIVI... | null | null | null | null | FUNCTION: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous syst... | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
B4F769 | SMAL1_RAT | MSLPLTEEQRKKIEENRQKALARRAEKLWAEQPQSTASGSSAARPSQCKQNSLLNLPAEPSKPEGHATISKGQNLNNSLPAAQRPHSSPCFQPSTAEEAKGLWKSEGKMSAACPNPSPPEVSNQQLLGSKSSEGHPQATQDTAASCPRPFPRDPKLEAKAGRPSTSGQSISDTFYALGEKTPKTDGRPAKALQTSPQKASCLRGMCLRTGDRFRVKIGYNKELIEVFKSLPSRRYDSFTKTWDFSMSDYRALMKAVERLSTVSLQPLEEVDGTGGQTSLPSAPSLTFVTGRCMLISRARFEVDIGYSEVVIALFKQMESR... | 3.6.4.- | null | DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; regulation of transcription by RNA polymerase II [GO:0006357]; replication fork processing [GO:0031297] | DNA replication factor A complex [GO:0005662]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861] | ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA/DNA annealing activity [GO:0036310]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] | PF07443;PF00271;PF00176; | 3.40.50.300;3.40.50.10810; | SNF2/RAD54 helicase family, SMARCAL1 subfamily | PTM: DNA damage-regulated phosphorylation by kinases that may include ATM, ATR and PRKDC. {ECO:0000250}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Recruited to damaged DNA regions. {ECO:0000250}. | null | null | null | null | null | FUNCTION: ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing ... | Rattus norvegicus (Rat) |
B4F779 | DP13B_RAT | MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSRQLLAYEKQNFALGKGDEEVISTLHYFSKVMDELNGLHSELAKQLADTMVLPVIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKRKENERVKTDVAKEVAAARRKQHLSSLQYYCALNALQYRKRAAMMEPLIGFAHGQINFFKKGAEMFSKSMDGFLSSVTDMVQSIQVELEAEADKMRVSQQELLSVSESVYTPDIDVATPQINRNLIQKTGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGG... | null | null | adiponectin-activated signaling pathway [GO:0033211]; cell cycle [GO:0007049]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cold acclimation [GO:0009631]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; negative regulation of cellular response to insulin stimulus [GO:1... | cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; early phagosome membrane [GO:0036186]; endosome [GO:0005768]; endosome membrane [GO:0010008]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886... | identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877] | PF16746;PF00169;PF00640; | 1.20.1270.60;2.30.29.30; | null | null | SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q8NEU8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NEU8}. Nucleus {ECO:0000250|UniProtKB:Q8NEU8}. Cell membrane {ECO:0000250|UniProtKB:Q8NEU8}. Endosome membrane {ECO:0000250|UniProtKB:Q8NEU8}. Cytoplasm {ECO:0000250|UniProtKB:Q8K3G9}. Cyto... | null | null | null | null | null | FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction wit... | Rattus norvegicus (Rat) |
B4F795 | CTL2_RAT | MGKDSQHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVLLFLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNADKPFLFYFNIVKCASPLVLLEFHCPTPQICVKQCPDRYLTFLSARNSRDFDYYKQFCVPGFKNNKGVAEVLRDGECPAVIIPSKPLAQRCFPAIHASKGVLMVGNETTYEDGHGTRKNVTDLVEGAKKANKVLEARQLAMQIFEDYTVSWYWIVIGLVIAMLLSLMFIVLLRFLAGVMVWVMIVMVILVLGYGIFHCYAEYSRLRGEAGSDVSLVDLGFQTDLRVYLHLRQTWMAFMI... | null | null | choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; transmembrane transport [GO:0055085] | membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; salt transmembrane transporter activity [GO:1901702]; transmembrane transporter activity [GO... | PF04515; | null | CTL (choline transporter-like) family | PTM: N-glycosylated. {ECO:0000250}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19236841}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:19236841}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly expressed in mitochondria. {ECO:0000269|PubMed:19236841}. | CATALYTIC ACTIVITY: Reaction=choline(out) + n H(+)(in) = choline(in) + n H(+)(out); Xref=Rhea:RHEA:75463, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378; Evidence={ECO:0000269|PubMed:19236841}; CATALYTIC ACTIVITY: Reaction=ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out); Xref=Rhea:RHEA:75467, ChEBI:CHEBI:15378, C... | null | null | null | null | FUNCTION: Exhibits choline transporter activity, as choline/H+ antiporter (PubMed:19236841). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy p... | Rattus norvegicus (Rat) |
B4F7B7 | DUS15_RAT | MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIVSIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTVVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFGEIPFRDEEDLRALLPLCRRCRQGPGTSAPSATTASSAASEGTLQRLVPRSPRESHRPLPLLARVKQTFFCLPRCLSRKGGK | 3.1.3.16; 3.1.3.48 | null | dephosphorylation [GO:0016311]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of oligodendrocyte differentiation [GO:0048713]; signal transduction [GO:0007165] | cytosol [GO:0005829]; plasma membrane [GO:0005886] | myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] | PF00782; | 3.90.190.10; | Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H1R2}; Lipid-anchor; Cytoplasmic side. | CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000250|UniProtKB:Q9H1R2, ECO:0000255|PROSITE-ProRu... | null | null | null | null | FUNCTION: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (PubMed:27532821). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (PubMed:27891578). May dephosphoryl... | Rattus norvegicus (Rat) |
B4F7C5 | LRRT4_RAT | MGFRLITQLKGMSVLLVLFPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNVSQETVNAWISLISITLSGNMWECSRSIC... | null | null | AMPA glutamate receptor clustering [GO:0097113]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of synapse assembly [GO:0051965]; regulation of presynaptic membrane organization [GO:1901629]; regulation of synapse assembly [GO:0051963]; synapse organization [GO:0050808] | AMPA glutamate receptor complex [GO:0032281]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; photoreceptor ribbon synapse [GO:0098684]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0... | heparan sulfate proteoglycan binding [GO:0043395] | PF13855; | 3.80.10.10; | LRRTM family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. | null | null | null | null | null | FUNCTION: May play a role in the development and maintenance of the nervous system (By similarity). Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation. {ECO:0000250, ECO:0000269|PubMed:19285470}. | Rattus norvegicus (Rat) |
B4F7E7 | PALS1_RAT | MTTSYMNGHVTEESDSGIKNLGLASPEEHPKHREMAVDCPGDLGTRLMPVRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYAVKILEVEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNRDFQNAFKIHNAVTVHMNKASPPFPLIANVQDLVQEVQTVLKPVHQKEGQELTALLNAPHIQALLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDL... | null | null | central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; gene expression [GO:0010467]; generation of neurons [GO:004... | adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; bicellular tight junction [GO:0005923]; Golgi apparatus [GO:0005794]; lateral loop [GO:0043219]; myelin sheath adaxonal region [GO:0035749]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; pr... | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein domain specific binding [GO:0019904] | PF00625;PF02828;PF09060;PF00595;PF07653; | 2.30.42.10;1.10.287.650;3.40.50.300;2.30.30.40; | MAGUK family | null | SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q8N3R9}. Cell membrane {ECO:0000250|UniProtKB:Q9JLB2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JLB2}. Endomembrane system {ECO:0000250|UniProtKB:Q9JLB2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JLB2}. Cell junction, tight junction {E... | null | null | null | null | null | FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component C... | Rattus norvegicus (Rat) |
B4FK49 | NDK1_MAIZE | MESTFIMIKPDGVQRGLIGEIISRFEKKGFYLKALKLVNVERSFAEKHYADLASKPFFQGLVDYIISGPVVAMVWEGKSVVTTGRKIIGATNPLASEPGTIRGDFAVDIGRNVIHGSDSIESANKEIALWFPEGPADWQSSQHPWIYEK | 2.7.4.6 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P22392}; | CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]; protein hexamerization [GO:0034214]; UTP biosynthetic process [GO:0006228] | nucleus [GO:0005634] | ATP binding [GO:0005524]; DNA binding [GO:0003677]; nucleoside diphosphate kinase activity [GO:0004550] | PF00334; | 3.30.70.141; | NDK family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000255|RuleBase:RU004013, ECO:0000269|PubMed:25679041}; CATALYTIC ACT... | null | null | null | null | FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Involved in transcription regulation (Probable). Has G-quadruplex (G4) DNA-bindin... | Zea mays (Maize) |
B4FZ81 | PTA12_MAIZE | MASCYNPWRLFPGMSTAVPAGPVTAPAHSRTCKSSKVFSALPHRRGLLFLGTRRARIKCVKDDSLHFDPSKIEPPPYSSYFDSTSGQLEPASGARASIPGKEYWPEGTAARVRAARAPAPVGESAGMPSFGTKPGSRRRGYKEQVTSASGTEGAQTDDRKDGDEPDVAIIGSGDDALEEIKDSVDEYVIYETPEEEELSEYDMDKMMGRPHPFIDPAKAMSLGEPKTSEELWWHWRRKSQEEEMWSRWQRRRPDVDTVFAKAMAETGQIKIFGDHPSRTEAALAKTRRHLYKEERLEAEQRRLEEIGPIAYYSEWVEAYK... | null | null | plastid transcription [GO:0042793]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of red or far-red light signaling pathway [GO:0090228]; positive regulation of thermomorphogenesis [GO:0140922]; protein catabolic process [GO:0030163]; regulation of gene expression [GO:0010468]; re... | chloroplast [GO:0009507]; chloroplast stroma [GO:0009570]; nucleus [GO:0005634]; plastid-encoded plastid RNA polymerase complex [GO:0000427] | single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription regulator activator activity [GO:0140537] | null | null | null | null | SUBCELLULAR LOCATION: Plastid, chloroplast stroma {ECO:0000269|PubMed:25599833}. Nucleus {ECO:0000269|PubMed:25599833}. | null | null | null | null | null | FUNCTION: Required for the activity of the plastid-encoded RNA polymerase (PEP) and full expression of genes transcribed by PEP (PubMed:24246379, PubMed:25599833). Required for the proper build-up and formation of the PEP-complex. Binds single-stranded (ss) DNA and RNA, but not double-stranded (ds) DNA (PubMed:25599833... | Zea mays (Maize) |
B4G2I8 | HH_DROPE | MDNHNEVPMSMSAPWASAARVTCLSLDAKCHRPCPSSISASASASGCASDSAAIATTKLRHIAYTQRCSSRLTMLMTVLLLLLPLSFTPAHSCGPGRGLGRRRERNLYPLVLKQTIPNLSEYQSGASGPLEGEIKRDSPKFKDLVPNYNRDILFRDEEGTGADRLMTKRCKEKLNVLAYSVMNEWPGVRLLVTESWDEDHQHGQESLHYEGRAVTIATSDREPSRYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLESGITKPLSEIAIGDRVLSMGSNGQPVYSEVILFMDRNLEQMQNF... | 3.1.-.- | null | anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:000... | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila persimilis (Fruit fly) |
B4G437 | SPAST_DROPE | MVRTKNQSSSSSASSSSHKSPIKSHGGSGSAAAGTAGHPVSRSSSSHRTSIDDRKSATNVSSSSNRRTTPGSSPDGDGDDDTTTTDDLTPTSTSAPRSAGGPSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNNSNNKDQKHQQLTSSQSLNYPLEVTSGEAASEQQVQQPLPQQRYRALQPLEMAGANRSGSGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREE... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila persimilis (Fruit fly) |
B4GAJ1 | LIS1_DROPE | MKMVLSQRQREELNQAIADYLGSNGYGDSLETFRKEADVSTESEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKYSLTGHRASITRVIFHPIFGLMVSASEDATIKIWDFETGEYERSLKGHTDSVQDVAFDSQGKLLASCSADLSIKLWDFQQSYECVKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDHTIRVWLMNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT... | null | null | border follicle cell migration [GO:0007298]; brain morphogenesis [GO:0048854]; centrosome localization [GO:0051642]; centrosome separation [GO:0051299]; chorion-containing eggshell pattern formation [GO:0030381]; clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883]; dendrite morphogenesis [GO:0048813]... | axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; growth cone [GO:0030426]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; neuronal cell body [GO:0043025]; nuclear envelope [GO:... | dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010] | PF08513;PF00400; | 1.20.960.30;2.130.10.10; | WD repeat LIS1/nudF family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. | null | null | null | null | null | FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. {ECO:0000255|HAMAP-Rule:MF_03141}. | Drosophila persimilis (Fruit fly) |
B4GBH0 | PTK7_DROPE | MDMDVMMISMCILASTLMAPGWASTSGFLRVPQSQSIVENEAADFGCEATDPASYLHYEWLHNGREISYDKRVYRIGSHLHIEAVQREEDVGDYVCIATSLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDEPLQIEWYRDSARLASWGNVHLEEHRLLVRQPSPSDDGLYRCTASNAAGRVMSKQGYVYQANIKCLPRLLKKNQKLPESWGKQTFLCRGKRGGSGGLDQALSPAPEDLRIVQGPAGQLLIKEGDSAALSCLYELPAELQNQRIQLRWRKDGKLLRHVELGGAIPIPGHAHDSGK... | null | null | cell adhesion [GO:0007155]; imaginal disc-derived female genitalia morphogenesis [GO:0048804]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; internal genitalia morphogenesis [GO:0035260]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell axon guidance [GO:0072499... | axon [GO:0030424]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; W... | PF07679;PF13927;PF07714; | 2.60.40.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6AWJ9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6AWJ9}. | null | null | null | null | null | FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in t... | Drosophila persimilis (Fruit fly) |
B4GFJ8 | RAS1_DROPE | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLTTWNVKNEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRRGRKLNKPNRRFKCKIL | 3.6.5.2 | null | border follicle cell migration [GO:0007298]; cellular response to starvation [GO:0009267]; chorion-containing eggshell pattern formation [GO:0030381]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; dorsal closure, spreading of leading edge cells [GO:0007395]; epidermal growth fact... | membrane [GO:0016020]; plasma membrane [GO:0005886] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; protein serine/threonine kinase activator activity [GO:0043539] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Ras family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08646}; Lipid-anchor {ECO:0000250|UniProtKB:P08646}; Cytoplasmic side {ECO:0000250|UniProtKB:P08646}. | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01112}; | null | null | null | null | FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormo... | Drosophila persimilis (Fruit fly) |
B4GJC1 | FICD_DROPE | MAMTILHASEKVNAEAEATTCPPTEKVKEEQQQQEQLQHSKTSKRVQFYRFALFFIAGSFAAFSFHALTSSSSWRLRQLHHLPNAHYLQTREEFAVYSVEELNAFKEFYDKSISDSVGASYSEAEQTNIKEALGALRLAQDMHLSGKDDKASRLFEHALALAPKHPEVLLRYGEFLEHNQRNIVLADQYYFQALTLCPSNSEALANRQRTAEVVQTLDERRLQSLDSKRDALSAIHESSSALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKLEITIKDILELH... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-261 determines which of the two op... | Drosophila persimilis (Fruit fly) |
B4GZN1 | WLS_DROPE | MSGTILENLSGRKLSILVGSLLLCQVLCFLLGGLYAPVPAGHTNVLGSLCRENHARQNDTSFFLYSRGEGSCTQVTREEVEQDSMKLANQIVHVFQMPLPRDSRVLDYSRWQQNLIGVLQVEFGYDSSSELREPPKELQLTIDMRLAYRNKGDPDHAWKLYAHGVEHRYLDCVAAHIGSSETLYTCDMIPLFELGALHHSFYLLNLRFPLDTPKQMNLQFGHMHDLTLTAIHQNGGFTHVWLMLKTLLFPFVVGIMVWFWRRVHLLQRSPALLEYMLLYLGGALTFLNLPLEYLSLTIEMPYMLLLSDIRQGIFYAMLLS... | null | null | compound eye morphogenesis [GO:0001745]; cuticle pattern formation [GO:0035017]; Golgi to plasma membrane protein transport [GO:0043001]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; intracellular protein transport [GO:0006886]; positive regulation ... | cell projection [GO:0042995]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membr... | Wnt-protein binding [GO:0017147] | PF06664; | null | Wntless family | null | SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass memb... | null | null | null | null | null | FUNCTION: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to ... | Drosophila persimilis (Fruit fly) |
B4H3U8 | SWS_DROPE | MDVLELLRVSGSNMYYSTFLADAWCYYISNQITMTMYLYCALGVLSMLFIGWFVYFKRLARLRLRHEIARSLSAVTMASGGDLRGPRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVIRFARRILQLRRENMPLEVRTVEPPAEYLEETMEGSDRVPPDALYMLQSIRIFGHFEKPIFLRLCKHTQLLELMGGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMAAFQEVFKDSPDVMIRVIQVIMIRLQRVLFTALRNYLGLNA... | 3.1.1.5 | null | ensheathment of neurons [GO:0007272]; glial cell apoptotic process [GO:0034349]; lipid catabolic process [GO:0016042]; membrane lipid metabolic process [GO:0006643]; membrane organization [GO:0061024]; neuron apoptotic process [GO:0051402]; phosphatidylcholine metabolic process [GO:0046470]; photoreceptor cell maintena... | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; protein kinase A catalytic subunit binding [GO:0034236] | PF00027;PF01734; | 3.40.1090.10;2.60.120.10; | NTE family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9U969}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9U969}. Note=Sws tethers Pka-C3 to the membrane. {ECO:0000250|UniProtKB:Q9U969}. | CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:Q9U969}; | null | null | null | null | FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in... | Drosophila persimilis (Fruit fly) |
B4HBU3 | PLK4_DROPE | MMSTRTFGETIEEYEVQHLLGKGGFASVYKARCLHSHQDVAIKMIDKKLIQGTGLTSRVRQEVEIHSRLKHPSVLQLYTFFQDVNYVYLVLELAHNGELQRYMKQHLLRPFTESEGATILRQVVAGLLYLHSHNIMHRDISLSNLLLSKEMHIKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRLSHGLPADVWSVGCMLYTLLVGRPPFETEGVESTLNKVVMSEFMMPSHLSFEAQDLIHKLLKKSPHERITLEQVLRHPFLKRTVGGSSYSTTPGALNEFSQSLASSDSGIVTFASSDSRKSHRLRSVDNSSG... | 2.7.11.21 | null | centriole replication [GO:0007099]; male meiotic nuclear division [GO:0007140]; mitotic spindle organization [GO:0007052]; phosphorylation [GO:0016310]; positive regulation of protein catabolic process [GO:0045732]; regulation of centriole replication [GO:0046599]; regulation of protein stability [GO:0031647]; sperm ax... | centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069;PF18190;PF18409; | 2.40.50.930;3.30.1120.120;3.30.1120.130;1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily | PTM: Ubiquitinated by the SCF(Slimb) ubiquitin ligase complex; leading to its degradation by the proteasome during interphase and regulating centriole number and ensuring the block to centriole reduplication. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is... | Drosophila persimilis (Fruit fly) |
B4HFB7 | HH_DROSE | MDNHSSVPWASAASVTCLSLDAKCHSSSSKSAASSISASPETQTMRHIAHTQRCLSRLTSLVALLLIVLPMMFSPAHSCGPGRGLGRHRARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTDGGAVLTVT... | 3.1.-.- | null | Bolwig's organ morphogenesis [GO:0001746]; cell-cell signaling involved in cell fate commitment [GO:0045168]; cytoneme assembly [GO:0035231]; epithelial cell migration, open tracheal system [GO:0007427]; genital disc anterior/posterior pattern formation [GO:0035224]; glial cell migration [GO:0008347]; gonadal mesoderm ... | cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila sechellia (Fruit fly) |
B4HGG6 | SPAST_DROSE | MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGVGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRL... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862;PF09336; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila sechellia (Fruit fly) |
B4HKC7 | RAS1_DROSE | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLASWNVNNEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRRGRKMNKPNRRFKCKML | 3.6.5.2 | null | border follicle cell migration [GO:0007298]; cellular response to starvation [GO:0009267]; chorion-containing eggshell pattern formation [GO:0030381]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; dorsal closure, spreading of leading edge cells [GO:0007395]; epidermal growth fact... | plasma membrane [GO:0005886] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; protein serine/threonine kinase activator activity [GO:0043539] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Ras family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08646}; Lipid-anchor {ECO:0000250|UniProtKB:P08646}; Cytoplasmic side {ECO:0000250|UniProtKB:P08646}. | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01112}; | null | null | null | null | FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormo... | Drosophila sechellia (Fruit fly) |
B4HNW4 | PTK7_DROSE | MISIYGLVMALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNAHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNQKMMESWDKQTFLCRGKRGGAAGLESLPAAPEDLRIVQGPVGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIIGHSFDSGKDALL... | null | null | cell adhesion [GO:0007155]; imaginal disc-derived female genitalia morphogenesis [GO:0048804]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; internal genitalia morphogenesis [GO:0035260]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell axon guidance [GO:0072499... | axon [GO:0030424]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; W... | PF07679;PF13927;PF07714; | 2.60.40.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6AWJ9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6AWJ9}. | null | null | null | null | null | FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in t... | Drosophila sechellia (Fruit fly) |
B4HSL3 | LIS1_DROSE | MKMVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKFSLTGHRASITRVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT... | null | null | border follicle cell migration [GO:0007298]; brain morphogenesis [GO:0048854]; centrosome localization [GO:0051642]; centrosome separation [GO:0051299]; chorion-containing eggshell pattern formation [GO:0030381]; clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883]; dendrite morphogenesis [GO:0048813]... | axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; growth cone [GO:0030426]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; neuronal cell body [GO:0043025]; nuclear envelope [GO:... | dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010] | PF08513;PF00400; | 1.20.960.30;2.130.10.10; | WD repeat LIS1/nudF family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. | null | null | null | null | null | FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. {ECO:0000255|HAMAP-Rule:MF_03141}. | Drosophila sechellia (Fruit fly) |
B4HWI2 | IRS1_DROSE | MASISDDGMALSGNLKKLKTMKKKFFVLYEETSTSSARLEYYDTEKKFLQRAEPKRVIYLKNCFNINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQRNIANSNGTAHSPYDQVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAVATNMHNMILSAMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQNSQNSLELRSCSSPHNYGFSRERCDSLPTRNGTLSESSNQTYFGSN... | null | null | cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; germ-line stem-cell niche homeostasis [GO:0060250]; glucose homeostasis [GO:0042593]; growth of a germarium-derived egg chamber [GO:0007295]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor s... | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase binding [GO:0043548] | PF02174; | 2.30.29.30; | null | null | null | null | null | null | null | null | FUNCTION: Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell prol... | Drosophila sechellia (Fruit fly) |
B4I1V5 | FICD_DROSE | MCTEAEQPSPPAQQQEQGNPPLCKAQNPKPARLYRLVLLFVAGSLAAWTFHALSSTNLVWKLRQLHHLPTAHYLQTRDEFALYSVEELNAFKEFYDKSVSDSVGASYTEAEQTNIKEALGALRMAQDLYLAGKDDKAARLFEHALALAPRHPEVLLRYGEFLEHNQRNIVLADQYYFQALTISPSNSEALANRQRTADVVQSLDERRLESLDSKRDALSAIHESNGALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKIDITIKDILELHRRVLGHVDPIEGGE... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-247 determines which of the two op... | Drosophila sechellia (Fruit fly) |
B4IAQ8 | PLK4_DROSE | MLSNRAFGETIEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTSRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARHFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRSSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHSAPGALNMFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQV... | 2.7.11.21 | null | centriole replication [GO:0007099]; male meiotic nuclear division [GO:0007140]; mitotic spindle organization [GO:0007052]; phosphorylation [GO:0016310]; positive regulation of protein catabolic process [GO:0045732]; regulation of centriole replication [GO:0046599]; regulation of protein stability [GO:0031647]; sperm ax... | centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069;PF18190;PF18409; | 2.40.50.930;3.30.1120.120;3.30.1120.130;1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily | PTM: Ubiquitinated by the SCF(Slimb) ubiquitin ligase complex; leading to its degradation by the proteasome during interphase and regulating centriole number and ensuring the block to centriole reduplication. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is... | Drosophila sechellia (Fruit fly) |
B4IL64 | SWS_DROSE | MDVLEMLRASASGSYNTIFSDAWCQYVSKQITATVYMYCALVMMSLLFIAWFLYFKRMARLRLRDELARSISTATNSSGDLRGLRFRKRDKMLFYGRRMLRKVKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAEL... | 3.1.1.5 | null | ensheathment of neurons [GO:0007272]; glial cell apoptotic process [GO:0034349]; lipid catabolic process [GO:0016042]; membrane lipid metabolic process [GO:0006643]; membrane organization [GO:0061024]; neuron apoptotic process [GO:0051402]; phosphatidylcholine metabolic process [GO:0046470]; photoreceptor cell maintena... | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; protein kinase A catalytic subunit binding [GO:0034236] | PF00027;PF01734; | 3.40.1090.10;2.60.120.10; | NTE family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9U969}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9U969}. Note=Sws tethers Pka-C3 to the membrane. {ECO:0000250|UniProtKB:Q9U969}. | CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:Q9U969}; | null | null | null | null | FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in... | Drosophila sechellia (Fruit fly) |
B4J2W3 | WLS_DROGR | MSGTILENLSGRKLSILVSSLMLCQVVCFLMGGLFAPVPAGHQTVLGSKCRDVPGRQNDTSFFLYSRGNGACKSLQDIDIEQDELKMANQLVYVFQMPLPRDNNTLQYSRWQQNLIGVLQVDIAYDSASELREPPKELQLTIDTRLAYRNQKDADTDWKLYAHSVEQRYLDCHASHVGRLETLYTCDIIPLFELGALHHNFYLLNLRFPMDTPKQMNLQFGHMHDLTLTAIHQNGGFTQVWLVLKTLLFPFVIGIMMWFWRRVHILQRSPALLEYMLFYLGGALSFLNLPLELLTLGVEMPYMLLLSDVRQGIFYAMLLS... | null | null | compound eye morphogenesis [GO:0001745]; cuticle pattern formation [GO:0035017]; Golgi to plasma membrane protein transport [GO:0043001]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; intracellular protein transport [GO:0006886]; positive regulation ... | cell projection [GO:0042995]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membr... | Wnt-protein binding [GO:0017147] | PF06664; | null | Wntless family | null | SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass memb... | null | null | null | null | null | FUNCTION: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to ... | Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
B4JBN5 | FICD_DROGR | METGKVTQEPKQMKFTYRFAFFFIAGSLATFVFHALTSSSSVSLFGWRLQLRQLHHLPTAHYLQTRDEFAVYSVDELNAFKEFYDKSVSDSVGASYTEAEQTNIKEALGAMRLALDMHISGKDDKAARLFEHALALAPKHPEVLLRYGEFLEHNQRNIVLADQYYFQALSISPSNSEAFANRQRTANVVQTLDERRLVSLDEKRDALSAIHEANAALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSVLETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKLEITLKDILELHRRVLGHVDPIEGGEFRRTQVYVGGH... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-236 determines which of the two op... | Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
B4JII0 | SPAST_DROGR | MVRTKNQSSSSSASSSTKSPVKISGGTTNRSRSCSDALIDDGNSKSSSKPTSNNRQRTTTNNNTTAITTTPGSSPDNDDDDTTTTDADLTPTSGNAPRGGNSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRSPNRRDCNIEIVVQNSKEQQQQHQHQQAIIHCPLERRGNISGIEQTLAQALPQRQRAIQPLEMAGNRAGGNYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDLQLQ... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862;PF09336; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
B4JTF5 | HH_DROGR | MDNEAVSALWSCASATCLSLDVKRHCSDANVDSQARTQSQATPMTNETDPRKLRHIAHTPRGSCFMTLLLLLLLALNFRHAHSCGPGRGLGRRRDRNLYPLVLKQTVPNLSEYQSGASGPLEGVIDRKSPKFKDLVPLYNSDILFRDEEGTGADRMMTKRCKEKLVMLATSVMNEWPGVKLLVTESWDEDHHHGEQSLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSSSISHVHGCFTPESTAQLESGAKKPLGELAIGDRVLSMDAKGQAVYSEVILFMDRNLEQMETFVQLHTDGG... | 3.1.-.- | null | anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:000... | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
B4JWA1 | LIS1_DROGR | MKMVLSQRQREELNQAIADYLGTNGYADSLEAFRKEADLSTEAEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKYSLTGHRASITRVIFHPIFGLMVSASEDATIKIWDFETGEYERTLKGHTDSVQDVAFDAQGKLLVSCSADLSIKLWDFQQSYECVKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDHTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT... | null | null | border follicle cell migration [GO:0007298]; brain morphogenesis [GO:0048854]; centrosome localization [GO:0051642]; centrosome separation [GO:0051299]; chorion-containing eggshell pattern formation [GO:0030381]; clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883]; dendrite morphogenesis [GO:0048813]... | axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; growth cone [GO:0030426]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; neuronal cell body [GO:0043025]; nuclear envelope [GO:... | dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010] | PF08513;PF00400; | 1.20.960.30;2.130.10.10; | WD repeat LIS1/nudF family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. | null | null | null | null | null | FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. {ECO:0000255|HAMAP-Rule:MF_03141}. | Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi) |
B4K4M0 | HH_DROMO | MDNNQAVSALWSCASATCLSLDAKRHSLEPSSPDGQASLDVNNKSAPVDAHARKLRHIAHTPRGSCFMALLLLLLLALNFRHAHSCGPGRGLGRRRERNLYPLVLKQTVPNLSEYHNGASGPLEGVIHRDSPKFKNLVLNYNKDILFRDEEGTGADRVMSKRCREKLNMLAYSVMNEWPGVRLLVTESWDEDHQHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSPSISHVHGCFTPESTALLESGAEKALSELAIGDRVLSMDTKGQPVYSEVILFMDRNLEQVQNFVQLHTD... | 3.1.-.- | null | anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:000... | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila mojavensis (Fruit fly) |
B4K799 | SPAST_DROMO | MVRTKNQSSSSSASSSTKSPVKISGGGSSGANRSRSCSEALIDDGKTSSKLSSNRQRATITTTTTSTTPGSSPDDDTTDADLTPTSGYGPRGGTSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYCASTKVIYRSPHRRDCNIEIVVQNSKEQQSIICPLERNTSDGIEKAQQLLPQRQRALLPLEMATNRGGSGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHEKMQTNLSMARDRLHFLALREEDLQMQRLSLMDPPKNKQQVTSK... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862;PF09336; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila mojavensis (Fruit fly) |
B4KFW6 | FICD_DROMO | MAMATGKATEEEQPEQGQQQQQLQQQQKQTTLQSTYRFALFFIAGCLAAFGFHALTSSSGSLLGWRLRLHHLPTAHYLQTRDEFAVYSVDELNAFKEFYDKSVSDSVGASLSEAEETNIKEAMGALRLAQEMYMTGKDDKAARLFEHALALAPKHPEVLLRYGEFLEHNQRNIVLADQYYFQALSINPSNTEALANRQRTADVVQLLDERRLSSLDEKRDALSAIHEANSALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSVLETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKLYITLKDILELHRRVLGHVDPI... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661;PF13428; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-251 determines which of the two op... | Drosophila mojavensis (Fruit fly) |
B4KPU0 | PTK7_DROMO | MPIVMDMNMLLMLSLAFTVMAPASASSSRFTQPPQSQAIVENDAADFSCEATGPSGDLHYEWLHNGQQIGYDSRVLQIGSNLRIESVQREDAGDYVCIAASAASGARQASPPAKLSVIFLDAVTVQLLGSNRNELLLKCHVEGASGDEPLQIEWYRDSAKLSSWQNVELQQHRLLVRQPSSADDGLYRCIASNAAARVMSKQGYVYEHLASVAPGSTKCLPKLKRNQKMPESWGKQVFLCRGKRGGSTGMDQSQSLPPSPEGLRIVQGPNDKLIIKEGEPTTLSCLYELPAELQNQRIQLRWRKDGKILRHVELGDAVVP... | null | null | cell adhesion [GO:0007155]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; imaginal disc-derived female genitalia morphogenesis [GO:0048804]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; internal genitalia morphogenesis [GO:0035260... | axon [GO:0030424]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]; transmembrane recept... | PF07679;PF13927;PF07714; | 2.60.40.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6AWJ9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6AWJ9}. | null | null | null | null | null | FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in t... | Drosophila mojavensis (Fruit fly) |
B4KT48 | LIS1_DROMO | MKMVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTESEKKYGGLLEKKWTSVIRLQKKVMDLEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKYSLTGHRASITRVIFHPIFGLMVSASEDATIKIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECVKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDHTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT... | null | null | border follicle cell migration [GO:0007298]; centrosome localization [GO:0051642]; centrosome separation [GO:0051299]; chorion-containing eggshell pattern formation [GO:0030381]; clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883]; dendrite morphogenesis [GO:0048813]; establishment of mitotic spindle... | axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; CIA complex [GO:0097361]; dendrite [GO:0030425]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; growth cone [GO:0030426]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; neuronal cell body [GO:0043025]; spindle pole centrosome [GO:00316... | dynein complex binding [GO:0070840] | PF08513;PF00400; | 1.20.960.30;2.130.10.10; | WD repeat LIS1/nudF family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. | null | null | null | null | null | FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. {ECO:0000255|HAMAP-Rule:MF_03141}. | Drosophila mojavensis (Fruit fly) |
B4L184 | WLS_DROMO | MSGTILENLSGRKLSILVSSLLLCQVACFLIGGLYAPVPAGHQIVMGIKCRDVAGRQNDTSFFLYSRGNGACDSVQDIDIEQDPLKMANQLVYVFQMPLPRDNRTLDYSRWQQNLIGVLQMDIAYDSSSELREPPKELQLTIDTRLAYRNKNDEDADWKPYAHSIEKRFLDCRAAHVGLQEILYTCDIIPLFELGALHHSFYLLNLRFPMDTPKRLNLQFGHMHDIILTAIHQNGGFTQVWLLLKSVLFPFIIGIMVWFWRRVHILQRSPALLEYMLLYLGGALSFLNLPLEYLTLSFEMPYMLLLSDVRQGIFYAMLLS... | null | null | compound eye morphogenesis [GO:0001745]; cuticle pattern formation [GO:0035017]; Golgi to plasma membrane protein transport [GO:0043001]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; intracellular protein transport [GO:0006886]; positive regulation ... | cell projection [GO:0042995]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membr... | Wnt-protein binding [GO:0017147] | PF06664; | null | Wntless family | null | SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass memb... | null | null | null | null | null | FUNCTION: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to ... | Drosophila mojavensis (Fruit fly) |
B4L535 | SWS_DROMO | MDVLELLRASVNGCYNTLFSDAWSQYVSKQIATTTYWYGALLAIGALFIAWFLYFKRLASLRLRDESARTLSALTAASGGDHRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLQRENRPLEMKTVEPPAEYLEETIDGSDRVPPDALYMLQSIRIFGHFEKPIFLKLCKHTQLLQLMAGDYLFKITDPDDSVYIVQSGMINVYICNADGSTLSLKTVRKGESVTSLLSFIDVLSGNSSYYKTVTAKAMEKSVVIRLPMQAFEEVFNENPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAE... | 3.1.1.5 | null | ensheathment of neurons [GO:0007272]; glial cell apoptotic process [GO:0034349]; lipid catabolic process [GO:0016042]; membrane lipid metabolic process [GO:0006643]; membrane organization [GO:0061024]; neuron apoptotic process [GO:0051402]; phosphatidylcholine metabolic process [GO:0046470]; photoreceptor cell maintena... | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; protein kinase A catalytic subunit binding [GO:0034236] | PF00027;PF01734; | 3.40.1090.10;2.60.120.10; | NTE family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9U969}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9U969}. Note=Sws tethers Pka-C3 to the membrane. {ECO:0000250|UniProtKB:Q9U969}. | CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:Q9U969}; | null | null | null | null | FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in... | Drosophila mojavensis (Fruit fly) |
B4LC58 | WLS_DROVI | MSGTILENLSGRKLSILVSSLMLCQVACFLMGGLYAPVPAGHQTVVGIKCRDVPGRQNDTNFFLYSRGNGACKSLQDMDIEQDPLKMANQLVYVFQMPLPRDNRTLDYSRWQQNLIGVLQVDIAYDSSSELREPPKELQLTIDTRLAYRNKKDADTDWKLYAHSVEQRYLDCHAAHVGLLETLYTCDIIPLFELGALHHNFYLLNLRFPIDTPKRMNLQFGHMHDLTLTAIHQNGGFTQVWLLLKTLLFPFVVGIMIWFWRRVHILQRSPALLEYMLLYLGGALSFLNLPLEYLTLSIEMPYMLLLSDVRQGIFYAMLLS... | null | null | compound eye morphogenesis [GO:0001745]; cuticle pattern formation [GO:0035017]; Golgi to plasma membrane protein transport [GO:0043001]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; intracellular protein transport [GO:0006886]; positive regulation ... | cell projection [GO:0042995]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membr... | Wnt-protein binding [GO:0017147] | PF06664; | null | Wntless family | null | SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass memb... | null | null | null | null | null | FUNCTION: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to ... | Drosophila virilis (Fruit fly) |
B4LG38 | UBP36_DROVI | MPVSLAVCETANVVNAALRESLGSGIGGGGGCVAAAASRSSAGSGSGSVAGVDEAKIGDVSGTDNLQSQIVANAKRVLLAKIEYEEVENYHESVLAKLKSKYIVIKPDNNNGAANCNYKTNGKAVGSNGHDNNTVNGGTVNGNRKQTVDSGQSNQNSSANPNELPKPKRVLYPRENIRIGWKQSERKWQVGAGMLNVGNTCYLNSTLQALFHIPALANWLVSETSHVENCNISESCGSGGCIICAMAKTLQTTQSNQSAVRPFLIYTKLRQICKHMVVGRQEDAHEFLRFLVEAMEKAYLMRFRNFKELDQLVKETTPIS... | 3.4.19.12 | null | germ-line stem cell population maintenance [GO:0030718]; heterochromatin formation [GO:0031507]; negative regulation of antimicrobial peptide production [GO:0002785]; negative regulation of innate immune response [GO:0045824]; negative regulation of macroautophagy [GO:0016242]; negative regulation of peptidoglycan reco... | cytosol [GO:0005829]; nucleolus [GO:0005730] | cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578] | PF00443; | 3.90.70.10; | Peptidase C19 family | null | SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; | null | null | null | null | FUNCTION: Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby prev... | Drosophila virilis (Fruit fly) |
B4LQ21 | LIS1_DROVI | MKMVLSQRQREELNQAIADYLGSNGYADSLEAFRKEADLSTEAEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKYSLTGHRASITRVIFHPIFGLMVSASEDATIKIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECVKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDHTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKT... | null | null | border follicle cell migration [GO:0007298]; brain morphogenesis [GO:0048854]; centrosome localization [GO:0051642]; centrosome separation [GO:0051299]; chorion-containing eggshell pattern formation [GO:0030381]; clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883]; dendrite morphogenesis [GO:0048813]... | axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cytoplasmic microtubule [GO:0005881]; dendrite [GO:0030425]; dynactin complex [GO:0005869]; dynein complex [GO:0030286]; growth cone [GO:0030426]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; neuronal cell body [GO:0043025]; nuclear envelope [GO:... | dynein complex binding [GO:0070840]; microtubule plus-end binding [GO:0051010] | PF08513;PF00400; | 1.20.960.30;2.130.10.10; | WD repeat LIS1/nudF family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. | null | null | null | null | null | FUNCTION: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. {ECO:0000255|HAMAP-Rule:MF_03141}. | Drosophila virilis (Fruit fly) |
B4LQT7 | FICD_DROVI | MAKAKAKQEPQQQRQTLQATYRFVLFFIAGSLAAFAFHALTSSTGSLMGWRLRLHHLPTAHYLQTRDEFAVYSVDELNAFKEFYDKSISDSVGASFTEAEQTNIKEAMGALRLAQEMYMAGKDDKAARLFEHALALAPKHPEVLLRYGEFLEHNQRNIVLADQYYFQALCISPSNSEALANRQRTADVVQTLDERRLISLDEKRDALSAIHEANSALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSVLETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKLEITLKDILELHRRVLGHVDPIEGGEFRRNQVYVGGH... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661;PF13428; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-236 determines which of the two op... | Drosophila virilis (Fruit fly) |
B4LX81 | SPNE_DROVI | MDSDLMDFFDFSKQFKRGTALKGCITGDPNALTTESRDSKPIKREKIGTDYVNEIVEKEKQLMNKLVDGQSVAKRNRTLDELDSDDEEENMQEQPSVRSDEAYYEKYRFDLNRNKNLPIYAQREQIMKAIRENPVVILKGETGCGKTTQVPQYILDEACKRREFCNIVVTQPRRIAAISIANRVCQERQWQPGTVCSYQVGLHRQSNVEDTRLLYCTTGVLLNNLIRLKTLTHYTHIVLDEVHERDQDMDFLLIVVRRLLALNSRHVKVILMSATIDTREFSKYFATSSAFPPVVTASHGRKYPLVKYYRDQLKNIHWKD... | 3.6.4.13 | null | dorsal appendage formation [GO:0046843]; germarium-derived oocyte fate determination [GO:0007294]; global gene silencing by mRNA cleavage [GO:0098795]; heterochromatin formation [GO:0031507]; intracellular mRNA localization [GO:0008298]; mitotic chromosome condensation [GO:0007076]; oocyte karyosome formation [GO:00307... | nucleus [GO:0005634]; P granule [GO:0043186] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | PF00270;PF21010;PF00271;PF00567; | 1.20.120.1080;2.30.30.140;2.40.50.90;3.40.50.300; | DEAD box helicase family, DEAH subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; | null | null | null | null | FUNCTION: Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements d... | Drosophila virilis (Fruit fly) |
B4LY29 | RAS1_DROVI | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLASWNVQNEQAREVAKQYGIPYIETSAKTRMGVDDAFYTLVREIRKDKDNKGRKGRKTNKPNRRFKCKML | 3.6.5.2 | null | border follicle cell migration [GO:0007298]; cellular response to starvation [GO:0009267]; chorion-containing eggshell pattern formation [GO:0030381]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; dorsal closure, spreading of leading edge cells [GO:0007395]; epidermal growth fact... | membrane [GO:0016020]; plasma membrane [GO:0005886] | G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; protein serine/threonine kinase activator activity [GO:0043539] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Ras family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08646}; Lipid-anchor {ECO:0000250|UniProtKB:P08646}; Cytoplasmic side {ECO:0000250|UniProtKB:P08646}. | CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01112}; | null | null | null | null | FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormo... | Drosophila virilis (Fruit fly) |
B4LZT9 | HH_DROVI | MDNQTVAAIWSCASATCLSLDAKRHSVETNTNDRQAPPGLSNSNNNNNNNKSTAVDADPRKLRHIAHTPRGSCFMALLLLLLLALNFRHAHSCGPGRGLGRRRERNLYPLVLKQTVPNLSEYMSGASGPIEGVIQRDSPNFKDLVPNYNRDIIFRDEEGTGADRLMSKRCREKLNTLSYSVMNEWPGVRLLVTESWDEDHQHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSPFISHVHGCFTPESTALLESGAKKPLSELAIGDRVLSMNGKGQAVYSEVILFMDRNLEQMQN... | 3.1.-.- | null | anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:000... | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila virilis (Fruit fly) |
B4M0H8 | SPAST_DROVI | MVRTKNQSSSSSASSSTKSPVKISGGGGGGGGSSSSTNRSRSCSEALIDDGKSSSKLSSNRQRTTTTITTTTTTPGSSPDDDTTDADLTPTSGNVPRGGQSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRSPHRRDCNIEIVVQNSKEQQAIICPLEGSGVNIEQAQILPQRQRALQTLEMAASRGGTGAGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHEKMQTNLSMARDRLHFLALREEDLQMQRLSLKEQPKKQ... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862;PF09336; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila virilis (Fruit fly) |
B4M709 | SWS_DROVI | MDVLELLRASANGCYNTLFSDAWFQYVSKQIATTMYWYGALLVIGVLFIAWFLYFKRLARLRLRDEIARSLSAVTSSGGDHRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLQRENRPLEMKTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPIFLKLCKHTQLLQLMAGDYLFKITDPDDSVYIVQSGMINVYICNADGSTLSLKTVRKGESVTSLLSFIDVLSGNSSYYKTVTAKAMEKSVVIRLPMQAFEEVFEENPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAEL... | 3.1.1.5 | null | ensheathment of neurons [GO:0007272]; glial cell apoptotic process [GO:0034349]; lipid catabolic process [GO:0016042]; membrane lipid metabolic process [GO:0006643]; membrane organization [GO:0061024]; neuron apoptotic process [GO:0051402]; phosphatidylcholine metabolic process [GO:0046470]; photoreceptor cell maintena... | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; protein kinase A catalytic subunit binding [GO:0034236] | PF00027;PF01734; | 3.40.1090.10;2.60.120.10; | NTE family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9U969}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9U969}. Note=Sws tethers Pka-C3 to the membrane. {ECO:0000250|UniProtKB:Q9U969}. | CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:Q9U969}; | null | null | null | null | FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in... | Drosophila virilis (Fruit fly) |
B4MR28 | PTK7_DROWI | MDMLMMWSICLFVCIFMAPFSCGSGSSSRFIQVPESQSIVENDSVDFNCEATTDPSTDLHYEWLHNGHQIVYDKRVYQIGANLHIESVQRGEDVGDYVCIAMSLSSGAREASPTAKLSVIFLDSASVQLLGSNRNELLLKCHVEGASGNEALQIEWYRNSAKLSSWQNIELDEHRLLVRQPTGSDDGLYRCIASNAAGRVMSKQGFVYQHQQQQQAGAKCLPRLKKNQKFLPESWGKQIFLCRGKRGGNVEAGLAPSPEGLRLVQGPDDQITIKEGEPATLSCLYEIPAELQNQRIQLRWRKDGKLLRQVELGASLPRGM... | null | null | cell adhesion [GO:0007155]; imaginal disc-derived female genitalia morphogenesis [GO:0048804]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; internal genitalia morphogenesis [GO:0035260]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell axon guidance [GO:0072499... | axon [GO:0030424]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; W... | PF07679;PF13927;PF07714; | 2.60.40.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6AWJ9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6AWJ9}. | null | null | null | null | null | FUNCTION: Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in t... | Drosophila willistoni (Fruit fly) |
B4MUQ2 | FICD_DROWI | MPWEFLKKCDRQKAEVRGEKEEQEPVPGNPHFQVQFHVTSCRFAFLAFLAGSFLAFSLHALISSNLFWRLRQLHHLPTAHYLQTRDEFAVYSVDELNAFKEFYDKSTADSVGATYTEAEETNIKEALSSLRLAQDMYMAGKDDKAARLFEHALALAPRHPEVLLRYGEFLEHNQRNIVLADQYYFQALTINPSHSEALANRQRTADVVQTLDERRLASLDAKRAALSAIHEANSALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKLEITIKDILELHRRVLGH... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-255 determines which of the two op... | Drosophila willistoni (Fruit fly) |
B4MXR8 | PLK4_DROWI | MLPVRNYGETIEEYEVQHLLGKGGFASVYKARCRRTYQDVAIKMIDKKLIHGTGLSSRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNQQMSHPFTEADAATILQQVVAGLLYLHSHNIMHRDISLSNLLLSKDMHVKIADFGLATQLKRPDEKHMTMCGTPNFISPEVVSRLSHGLAADVWSVGCLLYTLVVGRPPFDTDAVQSTLNKVVMSEFIMPTHLSFEACDLIEKLLKKNPHERISLEQVLRHPFMSKRSAGAEEPQYNSSKPGACDFYMEAQGQSVASGDSGIVTFASNESRSSQRL... | 2.7.11.21 | null | centriole replication [GO:0007099]; male meiotic nuclear division [GO:0007140]; mitotic spindle organization [GO:0007052]; phosphorylation [GO:0016310]; positive regulation of protein catabolic process [GO:0045732]; regulation of centriole replication [GO:0046599]; regulation of protein stability [GO:0031647]; sperm ax... | centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle pole [GO:0000922] | ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069;PF18190;PF18409; | 2.40.50.930;3.30.1120.120;3.30.1120.130;1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily | PTM: Ubiquitinated by the SCF(Slimb) ubiquitin ligase complex; leading to its degradation by the proteasome during interphase and regulating centriole number and ensuring the block to centriole reduplication. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is... | Drosophila willistoni (Fruit fly) |
B4N5D3 | WLS_DROWI | MSGTILENLSGRKLSILVSILLLCQVLCFLLGGIFAPVPAGHLTILGSLCRENHARQNDTNFFLYSRGDGACKQVTSEEVDADALKLANQIVHVFQLPLPRENKILEYTRWQQNLIGVLQVEFGYDSSPELHEPAKELQLTIDMRLAYRNNDDADNDWKLYAHSVEHRYLDCDTSHIGPTETLYTCDMIPLFELGALHHSFYLLNLRFPLDSPKQMNLQFGHMHDLTLTAIHQNGGFTKVWLFLKSVLFPFVVGIMVWFWRRVHLLQRSPALLEYMLIYLGGALTFLNLPLEYLTLGLEMPYMLLLSDIRQGIFYAMLLS... | null | null | compound eye morphogenesis [GO:0001745]; cuticle pattern formation [GO:0035017]; Golgi to plasma membrane protein transport [GO:0043001]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; intracellular protein transport [GO:0006886]; positive regulation ... | cell projection [GO:0042995]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; multivesicular body [GO:0005771]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic membr... | Wnt-protein binding [GO:0017147] | PF06664; | null | Wntless family | null | SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q95ST2}. Cell membrane {ECO:0000250|UniProtKB:Q95ST2}; Multi-pass memb... | null | null | null | null | null | FUNCTION: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to ... | Drosophila willistoni (Fruit fly) |
B4NBP4 | SPAST_DROWI | MVRTKSSSSSASSSSQKSPIKSNNGAGGGGSSSSHRQSHRTSIDERKSSSHAHSNNSNVSSSSRRAATATSGSSSPEGDDDTTTDDLTPTGSSPRSCNGRGHSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVLYRPHRRDCNIEIVVQNSKEQQLQLQQHQHNQTLSYSLETGGVSGGSGGEQQVQVQPQRIRALQPLEMATNRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWNGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDL... | 5.6.1.1 | null | adult locomotory behavior [GO:0008344]; cell division [GO:0051301]; hemocyte migration [GO:0035099]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic spindle elongation [GO:0000022]; negative regulation of microtubule depolymerization [GO:0007026]; negative regul... | centrosome [GO:0005813]; chromosome [GO:0005694]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule [GO:0005874]; neuromuscular junction [GO:0031594]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] | PF00004;PF17862;PF09336; | 1.10.8.60;3.40.50.300;1.20.58.80; | AAA ATPase family, Spastin subfamily | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021}. Chromosome {ECO:0000255|HAMAP-... | CATALYTIC ACTIVITY: Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.; EC=5.6.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_03021}; | null | null | null | null | FUNCTION: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Inv... | Drosophila willistoni (Fruit fly) |
B4NJP3 | HH_DROWI | MDSQSNQTPWASASVTCLSLDAKRHSQCLDDAIKSGHQVNYSPARSLRYIAYTQRCGIRLTMLMLIMCLTFMPAHSCGPGRGLGRRRVQNLYPLVLKQTVPNLSEHQLGASGPLEGEIPRDSPKFKDLVPNYNRDIVFKDEEGTGADRLMTKRCREKLNALAYSVMNEWPGVRLLVIESWDEDHDHGQESLHYEGRAVTIGTNDRDLSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSTISHVHGCFTPESTAQMENGEKKPLSQLSIGDRVLSMGSNGQPVYSEVILFMDRNLEQLENFVQLHTDGGAVLTVTPA... | 3.1.-.- | null | anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:000... | cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; morphogen activity [GO:0016015]; patched binding [GO:0005113]; peptidase activity [GO:0008233] | PF01085;PF01079; | 3.30.1380.10;2.170.16.10; | Hedgehog family | PTM: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that results ... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02936}. Cytoplasm {ECO:0000250|UniProtKB:Q02936}. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. {ECO:0000250|UniProtKB:Q02936}.; SUBCELLULAR ... | CATALYTIC ACTIVITY: [Protein hedgehog]: Reaction=cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA-COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI... | null | null | null | null | FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product) (By similarity). In addition, the C-terminal part displays a cholesterol transferase activity that res... | Drosophila willistoni (Fruit fly) |
B4NZY8 | IHOG_DROYA | MTLLTSSLLFFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPSHPSPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSSGAGFKYLRTGTAKANVSQEAAISRLKVLVRQDTLGEYRCVGWFGPLVVTSTIARLELASTSLLGGQESESPLQWRVSAGNSVLWPCGKQVKSNPSASWSYYRNGVEIKPEFIGTNGNIFLSNVSSESSGSYSCQATNPASGERIQLTGSLQLQVTPEQRSQSKSPHLLNGQPNSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVIGHALEISNTRVQDAG... | null | null | compound eye development [GO:0048749]; cuticle pattern formation [GO:0035017]; homotypic cell-cell adhesion [GO:0034109]; maintenance of protein location in extracellular region [GO:0071694]; segment specification [GO:0007379]; smoothened signaling pathway [GO:0007224]; wing disc anterior/posterior pattern formation [G... | cell surface [GO:0009986]; cytoneme [GO:0035230]; membrane [GO:0016020]; plasma membrane [GO:0005886] | coreceptor activity [GO:0015026]; hedgehog family protein binding [GO:0097108]; heparin binding [GO:0008201]; patched binding [GO:0005113]; protein homodimerization activity [GO:0042803] | PF00041;PF13895;PF13927; | 2.60.40.10; | Immunoglobulin superfamily, IHOG family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9VM64, ECO:0000255}. | null | null | null | null | null | FUNCTION: Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc). {ECO:0000250|UniProtKB:Q9VM64}. | Drosophila yakuba (Fruit fly) |
B4P0E1 | FICD_DROYA | MGTEAEQPSPPSPPAQQQEQTNPPLWNAQNQKPARLYRLVLFFIAGSLAAWTIHALSNSNLVWKLRQLHHLPTAHYLQTRDEFAVYSVEELNAFKEIYDKSVSDSVGASYTKDEQTSINEALVSLRMAQDMYLAGKDDKASRLFEHALALAPRHPEVLLRYGEFLEHSQRNIVLADQYYFQALTISPSNSEALANRQRTADVVQTLDERRLQSLDSKRDALSAIHESNGALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSILETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKIDITIKDILELHRRVLGHVDPIE... | 2.7.7.108; 3.1.4.- | null | detection of light stimulus involved in visual perception [GO:0050908]; histamine transport [GO:0051608]; protein adenylylation [GO:0018117]; response to endoplasmic reticulum stress [GO:0034976]; visual behavior [GO:0007632] | plasma membrane [GO:0005886] | AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803] | PF02661; | 1.10.3290.10;1.25.40.10; | Fic family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8SWV6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8SWV6}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; Evidence={ECO:0000250|UniProtKB:Q9BVA6}; CATALYTIC ACTIV... | null | null | null | null | FUNCTION: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-250 determines which of the two op... | Drosophila yakuba (Fruit fly) |
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