Entry stringlengths 6 10 | Entry Name stringlengths 5 11 | Sequence stringlengths 2 35.2k | EC number stringlengths 7 118 ⌀ | Cofactor stringlengths 38 1.77k ⌀ | Gene Ontology (biological process) stringlengths 18 11.3k ⌀ | Gene Ontology (cellular component) stringlengths 17 1.75k ⌀ | Gene Ontology (molecular function) stringlengths 24 2.09k ⌀ | Pfam stringlengths 8 232 ⌀ | Gene3D stringlengths 10 250 ⌀ | Protein families stringlengths 9 237 ⌀ | Post-translational modification stringlengths 16 8.52k ⌀ | Subcellular location [CC] stringlengths 29 6.18k ⌀ | Catalytic activity stringlengths 64 35.7k ⌀ | Kinetics stringlengths 69 11.7k ⌀ | Pathway stringlengths 27 908 ⌀ | pH dependence stringlengths 64 955 ⌀ | Temperature dependence stringlengths 70 1.16k ⌀ | Function [CC] stringlengths 17 15.3k ⌀ | Organism stringlengths 8 196 |
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F1M0Z1 | TRIO_RAT | MSGSSGGATAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRMRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHIALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNAAHMLSRLEELQDVLAKKELPQDLEGARNMIDEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHS... | 2.7.11.1 | null | axon guidance [GO:0007411]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of fat cell differentiation [GO:0045599]; neuron projection morphogenesis [GO:0048812]; phosphorylation [GO:0016310]; postsynaptic modulation of chemical synaptic transmission [GO:0099170] | cell projection [GO:0042995]; cytoplasm [GO:0005737]; extrinsic component of membrane [GO:0019898]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynaptic active zone [GO:0048786]; Schaffer collateral - CA1 synapse [GO:0098685] | ATP binding [GO:0005524]; enzyme binding [GO:0019899]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF13716;PF07679;PF00169;PF00069;PF00621;PF16609;PF00018;PF00435; | 1.20.58.60;3.40.525.10;1.20.900.10;2.60.40.10;2.30.29.30;2.30.30.40;1.10.510.10; | Protein kinase superfamily, CAMK Ser/Thr protein kinase family | PTM: Phosphorylated on serine residue(s). {ECO:0000250|UniProtKB:O75962}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q0KL02}. Cell projection {ECO:0000250|UniProtKB:Q0KL02}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[pr... | null | null | null | null | FUNCTION: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons... | Rattus norvegicus (Rat) |
F1M386 | RPGF2_RAT | MKPLAAPANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWF... | null | null | adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellula... | apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; late endosome [GO:0005770]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:00... | beta-1 adrenergic receptor binding [GO:0031697]; cAMP binding [GO:0030552]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; phosphatidic acid binding [GO:0070300]; protein kinase binding [GO:0019901]; WW domain binding [GO:0050699] | PF00595;PF00788;PF00617;PF00618; | 2.30.42.10;2.60.120.10;1.10.840.10;1.20.870.10; | RAPGEF2 family | PTM: Ubiquitinated by NEDD4, leading to proteasomal degradation. {ECO:0000250}.; PTM: Phosphorylation by PLK2 promotes its activity. {ECO:0000269|PubMed:21382555}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17724123}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction {ECO:0000250}. Note=Associated with the synaptic plas... | null | null | null | null | null | FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Ra... | Rattus norvegicus (Rat) |
F1M391 | STING_RAT | MPYSNLHPSIPRPRSYRFKLAAFVLLVGSLMSLWMTGEPPSHTLHYLALHVASQQLGLLLKKLCCLAEELCHVQSRYQGSYWKAVRACVGSPICFMALILLSFYFYCSLENTSDLRLAWHLGILVLSKSLSMTLDLQSLAPAEVSAVCEEKNFNVAHGLAWSYYIGYLKLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDDLSVADPNIRFRDMLPQQNTDRAGVKNRAYSNSVYELLENGQPAGACILEYATPLQTLFAMSQDGKAGFSREDRLEQAKLFCRTLEEILADVPESRNHCRLIVYQESEEG... | null | null | activation of innate immune response [GO:0002218]; antiviral innate immune response [GO:0140374]; autophagosome assembly [GO:0000045]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; cGAS/STING signaling pat... | autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:00... | 2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; proton channel activity [GO:0015252]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:006162... | PF15009; | 1.20.5.5200;3.40.50.12100; | STING family | PTM: Phosphorylation by TBK1 leads to activation and production of IFN-beta. Following cyclic nucleotide (c-di-GMP or cGAMP)-binding, activation and translocation from the endoplasmic reticulum, STING1 is phosphorylated by TBK1 at Ser-366 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding mo... | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q86WV6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86WV6, ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q86WV6}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q86WV6}; Multi-... | CATALYTIC ACTIVITY: Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence={ECO:0000250|UniProtKB:Q86WV6}; | null | null | null | null | FUNCTION: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26669264). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivere... | Rattus norvegicus (Rat) |
F1M3G7 | AKP13_RAT | MKLSPQQAPLYGDCVVTVLLAEEDKVEDDAIFYLIFSGSTLYHCTSTRKVSSDTLETIAPGHDCCETVKVLLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLDRSGPPSGDVNSLDEKVALAFRHLKLPAEWNVLGTDHTLHDGGPRETLMHFAVRLGLLRLTWFLLQKPGGRGALSIHNKEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDYSVRHHRELDIYTLTSESESHCEPHGDSCTGHISKLMNIQQQLMKTNLKQMDNLMPLMVTTQDSSCVPCVPEPSDHQQL... | null | null | adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [GO:0086023]; adrenergic receptor signaling pathway [GO:0071875]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; cell growth involved in cardiac muscle cell development [GO:0061049]; G protein-... | actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] | guanyl-nucleotide exchange factor activity [GO:0005085]; MAP-kinase scaffold activity [GO:0005078]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267] | PF17838;PF00621; | 3.30.60.20;1.20.900.10;2.30.29.30; | null | null | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q12802}. Cytoplasm {ECO:0000250|UniProtKB:Q12802}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q12802}. Nucleus {ECO:0000250|UniProtKB:Q12802}. Membrane {ECO:0000250|UniProtKB:Q12802}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q12802}. Note=Colo... | null | null | null | null | null | FUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:17537920). May also activate ot... | Rattus norvegicus (Rat) |
F1M3J4 | MRP4_RAT | MLPVHTEVKPNPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRAKKDARKPSLTKAIVKCYWKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYAAVLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMN... | 7.6.2.-; 7.6.2.2; 7.6.2.3 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:O15439}; | bile acid and bile salt transport [GO:0015721]; bile acid signaling pathway [GO:0038183]; cAMP transport [GO:0070730]; cilium assembly [GO:0060271]; export across plasma membrane [GO:0140115]; leukotriene transport [GO:0071716]; positive regulation of smooth muscle cell proliferation [GO:0048661]; prostaglandin secreti... | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088] | ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmem... | PF00664;PF00005; | 1.20.1560.10;3.40.50.300; | null | PTM: N-glycosylated; leading to substrate-selective effects on its transport activity. {ECO:0000250|UniProtKB:O15439}. | SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12883481}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O15439}; Multi-pass membrane protein {ECO:0000255}. Note=Its localization to the basolateral or apical membranes is tissue-dependent. {ECO:0000250|UniProt... | CATALYTIC ACTIVITY: Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.; EC=7.6.2.2; Evidence={ECO:0000250|UniProtKB:O15439}; CATALYTIC ACTIVITY: Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:... | null | null | null | null | FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cycl... | Rattus norvegicus (Rat) |
F1M3L7 | EPS8_RAT | MNGHMSNHSSGYGIYPSQMNGYGSSPPYSQMDREHCSRTSAKALYEQRKNYARDSVSSVSDVSQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVAHTCSYDSILALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPEALRMIAKADPGIPPPPRAPAPVPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKSKKSKRKGPGEGVLTLRA... | null | null | actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149... | brush border [GO:0005903]; cell cortex [GO:0005938]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; stereocilium [GO:0032420]; stereocilium bundle [GO:003... | actin binding [GO:0003779]; small GTPase binding [GO:0031267] | PF08416;PF18016;PF00018; | 2.30.29.30;2.30.30.40;1.10.150.50; | EPS8 family | PTM: Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during G2 phase, leading to its transient degradation and subsequent cell shape changes required to allow mitotic progression. Reappears at the midzone of dividing cells (By similarity). {ECO:0000250}.; PTM: Phosphorylation at Ser-625 and Thr-629 ... | SUBCELLULAR LOCATION: Synapse, synaptosome. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cell projection, stereocilium {ECO:0000250, ECO:0000250|UniProtKB:Q08509}. Cell projection, growth cone. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (By s... | null | null | null | null | null | FUNCTION: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of sign... | Rattus norvegicus (Rat) |
F1M4A4 | KIF1A_RAT | MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG... | null | null | anterograde axonal transport [GO:0008089]; anterograde neuronal dense core vesicle transport [GO:1990048]; cytoskeleton-dependent intracellular transport [GO:0030705]; dense core granule cytoskeletal transport [GO:0099519]; interkinetic nuclear migration [GO:0022027]; microtubule-based movement [GO:0007018]; protein tr... | axon [GO:0030424]; axon cytoplasm [GO:1904115]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO... | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574] | PF12473;PF00498;PF12423;PF00225;PF16183;PF00169; | 2.60.200.20;6.10.250.2520;3.40.850.10;2.30.29.30; | TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Unc-104 subfamily | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q12756}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q12756}. Cell projection, axon {ECO:0000250|UniProtKB:P33173}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P33173}. Synapse {ECO:0000250|UniProtKB:P33173}. Cytoplasmic vesicle... | null | null | null | null | null | FUNCTION: Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons (PubMed:29166604, PubMed:30021165). The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with t... | Rattus norvegicus (Rat) |
F1M5F3 | MCM9_RAT | MNSEQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPLVVNAMTLFETNMEIGDYFTVFPNEVLTVFDSALRRSALAVLQSLPEPEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKYVFTVKADFEQYYTFSRPSSCPSSDTCDSSKFTCLSDLSASPARCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQRWKPFQRDMRCEVEIVLKANYVQVNNEQSSGMVMDEDARKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLV... | 3.6.4.12 | null | DNA damage response [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; gamete generation [GO:0007276]; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication [GO:0070716]; pr... | chromosome [GO:0005694]; MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA helicase activity [GO:0003678]; enzyme binding [GO:0019899]; MutLbeta complex binding [GO:0032406]; MutSalpha complex binding [GO:0032407]; MutSbeta complex binding [GO:0032408]; protein-containing complex binding [GO:00... | PF00493;PF17855;PF17207; | 2.40.50.140;3.40.50.300; | MCM family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NXL9}. Chromosome {ECO:0000250|UniProtKB:Q9NXL9}. Note=Colocalizes to nuclear foci with RPA1 following DNA damage. Localizes to double-stranded DNA breaks. Recruited to chromatin by MSH2. {ECO:0000250|UniProtKB:Q9NXL9}. | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000250|UniProtKB:Q9NXL9}; | null | null | null | null | FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promot... | Rattus norvegicus (Rat) |
F1M5M3 | TEX14_RAT | MSRAVHFPVPCPVLLGTLTDDSLEAQLHEYAKQGNYVKVKKILKKGVCVDAVNTLGQSALFVAALLGYVKLVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKVLTAGGDLRLHDEKGRNPQAWALAAGKDRSTQMVEFMQRCASHMKAVIQGFSYDLLKKIDSPQRLIGSPPWFGGLIQGSPNSSPNRQPKPGIISAQNIYSFGFGKFYLTSGMQLTYPGSLPVIGEKEVIQADDEPTFSFFSGPYMVMTNLVWNRSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSNLRHPSLLQLMAVCLSRDLEKIRLVY... | null | null | attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; cellular response to leukemia inhibitory factor [GO:1990830]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly... | cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; midbody [GO:0030496] | ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901] | PF12796;PF07714; | 1.25.40.20;1.10.510.10; | Protein kinase superfamily | PTM: Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-431 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Midbody {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}. | null | null | null | null | null | FUNCTION: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting th... | Rattus norvegicus (Rat) |
F1M5N7 | KI21B_RAT | MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRGIDERKRRAQEQGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGTAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVH... | null | null | brain development [GO:0007420]; corpus callosum development [GO:0022038]; microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] | cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; microtubule [GO:0005874] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] | PF00225;PF00400; | 3.40.850.10;2.130.10.10; | TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXL1}. Cytoplasmic vesicle {ECO:0000269|PubMed:25172774}. | null | null | null | null | null | FUNCTION: Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-amino... | Rattus norvegicus (Rat) |
F1M625 | UBP46_RAT | MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENSKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKS... | 3.4.19.12 | null | adult feeding behavior [GO:0008343]; behavioral fear response [GO:0001662]; behavioral response to ethanol [GO:0048149]; proteolysis [GO:0006508]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic transmission, GABAergic [GO:0032228]; righting reflex [GO:0060013] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; synapse [GO:0045202] | cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; metal ion binding [GO:0046872] | PF00443; | 3.90.70.10; | Peptidase C19 family, USP12/USP46 subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62068}. Note=USP46/WDR48/WDR20 complex is predominantly cytoplasmic. {ECO:0000250|UniProtKB:P62068}. | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:22043315}; | null | null | null | null | FUNCTION: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitinatio... | Rattus norvegicus (Rat) |
F1M649 | NLRC4_RAT | MNFIKENSQALIQRMGIVVIKQICDDLFALNVLNGEEVAIICSHRVEQDAARDIVHMILKKGSAACNLFLKSLENWNYPVYQDLTGHSLFHQNLEEDLDVLAQSLKDLYNSPVFKNFFPLGEDIDIIFNLQITFTEPVLWRKDHRHHRVEQMTLGSLLEALKSPCLIEGESGKGKSTLLQKIAMLWASGMCPALNQFKLVFFIRLSSARGGLFETLYDQLVNIPDSISKPTFRALLLKLHKKVLFLLDAYNEFHPQNCPEIEALVKENHRFKNMVIVTTTTECLRHIRHVGALTVEVGDMTEDSARVLIREVLINELAEG... | null | null | activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; detection of bacterium [GO:0016045]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of inter... | cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; IPAF inflammasome complex [GO:0072557]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; caspase binding [GO:0089720]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] | PF00619;PF05729;PF17889; | 1.10.1900.50;1.10.533.10;3.40.50.300;3.80.10.10; | null | PTM: Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro. {ECO:0000250|UniProtKB:Q3UP24}. | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q3UP24}. | null | null | null | null | null | FUNCTION: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune resp... | Rattus norvegicus (Rat) |
F1M707 | NCF1_RAT | MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRKFTEIYEFHKMLKEMFPIEAGEIHTENRVIPHLPAPRWYDGQRAAESRQGTLTEYFNSLMGLPMKISRCPHLLNFFKVRPDDLKLPNDSQVKKPETYLTAKDGKNNVADITGPIILQTYRAIADYEKGSKTEMTVATGDVVDVVEKSESGWWFCQMKTKRGWVPASYLEPLDSPDEAEDPDPNYAGEPYVTIKAYAAVEEDEVSLSEGEAIEVIHKLLDGWWVVRKGDITGYFPSMYLQKAGEEITQAQRQIRSRGAPPRRSTIRNAQSIHQRSRKRL... | null | null | cellular defense response [GO:0006968]; cellular response to cadmium ion [GO:0071276]; cellular response to glucose stimulus [GO:0071333]; cellular response to reactive oxygen species [GO:0034614]; cellular response to testosterone stimulus [GO:0071394]; defense response to bacterium [GO:0042742]; defense response to f... | cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; NADPH oxidase complex [GO:0043020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] | phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; SH3 domain binding [GO:0017124]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activator activity [GO:0016176] | PF16621;PF08944;PF00787;PF00018; | 3.30.1520.10;2.30.30.40; | null | PTM: Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity. {ECO:0000250|UniProtKB:P14598}. | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P14598}. Membrane {ECO:0000250|UniProtKB:P14598}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14598}; Cytoplasmic side {ECO:0000250|UniProtKB:P14598}. | null | null | null | null | null | FUNCTION: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250|UniProtKB:P14598, ECO:0000250|UniProtKB:Q09014}. | Rattus norvegicus (Rat) |
F1M775 | DIAP1_RAT | MEPSGGGLGPGRGTRDKKKGRSPDELPATGGDGGKHKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDISDDQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQYLHTSKAGMNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMEEVERFQPLLDGLKSGTSIALKVGCLQLINA... | null | null | actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; actin nucleation [GO:0045010]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cellular response to histamine [GO:0071420]; cytoskeleton organization [GO:0007010]; ephrin receptor signaling path... | actin filament [GO:0005884]; brush border [GO:0005903]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; nucleus [GO:0005634]; presynapse [GO:0098793]; ruffle membrane [GO:0032587]; synapse [GO:0045202] | actin binding [GO:0003779]; identical protein binding [GO:0042802]; profilin binding [GO:0005522]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] | PF06346;PF06367;PF06371;PF02181; | 1.20.1170.10;1.20.58.630;6.10.30.30;1.10.20.40;1.20.58.2220;1.10.238.150;1.25.10.10; | Formin homology family, Diaphanous subfamily | PTM: Phosphorylation at Thr-761 is stimulated by cAMP and regulates stability, complex formation and mitochondrial movement (By similarity). {ECO:0000250|UniProtKB:O60610}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O08808}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O08808}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O08808}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O60610}. Cytoplasm, cytoskeleton, spindle... | null | null | null | null | null | FUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response... | Rattus norvegicus (Rat) |
F1M7L9 | PKP2_RAT | MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPVARSQRIQEQVQQTLARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQSPAARDYDMLKVGLSGWRDGSTLKVPCTSIKPHREKKTWIEALREGLEHTTDHTDCPAHYVYSHYYFNSKKSNILVFQHIKDKSLQRNAIILLSPEHCTCQHVRLIPSSVLPSLFNQLQLSPELYFSNMGTLYMTSIKGTLCIQLLKGKLPAKHQANFVTMAERRVYTLLLSSTTSSETSFRRTGDTLPSVTSGQSRVHGLHFHHVICDCLSRNADLEM... | null | null | adherens junction maintenance [GO:0034334]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cardiac muscle cell action potential [GO:0086001]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cell-cell adhesion [GO:0098609]; cell-cell signaling involve... | adherens junction [GO:0005912]; cell junction [GO:0030054]; cell tip [GO:0051286]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; intermediate filament binding [GO:0019215]; molecular adaptor activity [GO:0060090]; protein kinase C binding [GO:0005080] | PF00514; | 1.25.10.10; | Beta-catenin family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99959}. Cell junction, desmosome {ECO:0000269|PubMed:21617128}. Cell junction {ECO:0000269|PubMed:19661460, ECO:0000269|PubMed:26858265}. Cytoplasm {ECO:0000250|UniProtKB:Q99959}. Note=Colocalizes with CTNNA3 and SCN5A/Nav1.5 at intercalated disks in the heart. {ECO... | null | null | null | null | null | FUNCTION: Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (By similarity). Required to maintain gingival epithelial barrier function (By similarity). Required for cardiac sodium current propagat... | Rattus norvegicus (Rat) |
F1M7Y5 | KPCI_RAT | MPTQRDSSTMSHTVACGGGGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCSEVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQSSMHPDHTQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS... | 2.7.11.13 | null | actin filament organization [GO:0007015]; cell migration [GO:0016477]; cell-cell junction organization [GO:0045216]; cellular response to insulin stimulus [GO:0032869]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photo... | apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; microtubule cytoskele... | ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00130;PF00564;PF00069;PF00433; | 3.30.60.20;1.10.510.10; | Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily | PTM: Phosphorylation at Thr-412 in the activation loop is not mandatory for activation (By similarity). Upon neuronal growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-265, Tyr-280 and Tyr-334 (By similarity). Phosphorylation at Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI in... | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11891849}. Membrane {ECO:0000250|UniProtKB:P41743}. Endosome {ECO:0000250|UniProtKB:P41743}. Nucleus {ECO:0000269|PubMed:11891849}. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus throu... | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[p... | null | null | null | null | FUNCTION: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. ... | Rattus norvegicus (Rat) |
F1M8W4 | SOX5_RAT | MLTDPDLPQEFERMSSKRPASPYGETDGEVAMVTSRQKVEEEESERLPAFHLPLHVSFPNKPHSEEFQPVSLLTQEACGPRTPAAQHSTMEVDGNKVMSSLAPYNSSTSPQKAEEGGRQSGESVSSAALGTPERRKGSLADVVDTLKQRKMEELIKNEPEDTPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIP... | null | null | asymmetric neuroblast division [GO:0055059]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system neuron differentiation [GO:0021953]; chondrocyte differentiation [GO... | nucleus [GO:0005634]; transcription regulator complex [GO:0005667] | cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory r... | PF00505; | 1.10.30.10; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35710}. | null | null | null | null | null | FUNCTION: Transcription factor involved in chondrocytes differentiation and cartilage formation (By similarity). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as ... | Rattus norvegicus (Rat) |
F1MA98 | TPR_RAT | MAAVLQQVLERPELNKLPKSTQNKLEKFLAEQQSEIDCLKGRHEKFKVESEQQYFEIEKRLSQSQERLVNETRECQNLRLELEKLNNQVKVLTEKNKELETAQDRNLGIQSQFTRAKEELEAEKRDLIRTNERLSQEVEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVTVKYREKRLEQEKELLHNQNSWLNTELKTKTDELLALGREKGNEILELKCTLENKKEEVLRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVDELHKLLKEAGEA... | null | null | cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA export from nucleus [GO:0006406]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export f... | cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615];... | chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631... | PF07926; | 1.10.287.1490; | TPR family | PTM: Phosphorylated. Phosphorylation occurs on serine and threonine residues (comprised in the C-terminal region) by MAPK1/ERK2 and stabilizes the interaction between these two proteins (By similarity). {ECO:0000250}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P12270}. Nucleus membrane {ECO:0000250|UniProtKB:P12270}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12270}; Nucleoplasmic side {ECO:0000250|UniProtKB:P12270}. Nucleus envelope {ECO:0000250|UniProtKB:P12270}. Nucleus, nuclear pore complex {ECO:0000269|PubMed... | null | null | null | null | null | FUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral ch... | Rattus norvegicus (Rat) |
F1MAB7 | DGKI_RAT | MDAAGRGCHLLPLPAARGPARAPAASSALSPAGLCSGTASASSAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGVDPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWII... | 2.7.1.107 | null | diacylglycerol metabolic process [GO:0046339]; excitatory postsynaptic potential [GO:0060079]; habituation [GO:0046959]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; neurotransmitter secretion [GO:0007269]; phosphatidic acid biosynthetic process [GO:0006654]; positive regulation o... | axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; extrinsic component of postsynaptic density membrane [GO:0099147]; extrinsic component of presynaptic active zone membrane [GO:0098891]; glutamatergic synapse [GO:0098978]; guanyl-nuc... | ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; GTPase inhibitor activity [GO:0005095]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] | PF12796;PF00130;PF00609;PF00781; | 2.60.200.40;3.30.60.20;1.25.40.20; | Eukaryotic diacylglycerol kinase family | null | SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000269|PubMed:21119615}. Cell projection, dendrite {ECO:0000269|PubMed:21119615}. Presynapse {ECO:0000269|PubMed:21119615}. Postsynapse {ECO:0000269|PubMed:21119615}. Postsynaptic density {ECO:0000269|PubMed:21119615}. Synaptic cell membrane {ECO:0000269|PubMed:21119615... | CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence={ECO:0000269|PubMed:15024004}; PhysiologicalDirection=left-to-right... | null | PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000269|PubMed:15024004}. | null | null | FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15024004). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targ... | Rattus norvegicus (Rat) |
F1MAD2 | INADL_RAT | MPENPAAEKMQVLQVLDRLRGKLQEKGDTTQNEKLSAFYETLKSPLFNQILTLQQSIKQLKGQLSHIPSDCSANFDFSRKGLLVFTDGSITNGNAHRPCSSITASESLPWTQRSGNEDFTSVIQQMAQGRHIEYIDIERPSTGGLGFSVVALRSQSLGLIDIFVKEVHPGSVADRDQRLKENDQILAINDTPLDQNISHQQAIALLQQATGSLRLVVAREVGHTQSRTSTSSADTTLPETVRWGHTEDVELINDGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGSTNVQGMTSEQVAQVLRNCGNSV... | null | null | establishment of apical/basal cell polarity [GO:0035089]; microtubule organizing center organization [GO:0031023]; regulation of microtubule cytoskeleton organization [GO:0070507]; tight junction assembly [GO:0120192] | apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; subapical complex [GO:0035003]; tight junction [GO:0070160] | null | PF09045;PF00595; | 1.20.1440.360;2.30.42.10; | null | null | SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q8NI35}. Apical cell membrane {ECO:0000250|UniProtKB:Q8NI35}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NI35}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63ZW7}. Note=Localizes to the apical region at the start of epithelia... | null | null | null | null | null | FUNCTION: Scaffolding protein that facilitates the localization of proteins to the cell membrane (By similarity). Required for the correct formation of tight junctions and epithelial apico-basal polarity (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facili... | Rattus norvegicus (Rat) |
F1MH07 | MICA1_BOVIN | MASTISTNPAHAHFESFLQAQLCQDVLSSFQGLCGALGVEPGGGLSQYHKVKAQLNYWNAKSLWAKLDKRASQPVYQQGRACTGTKCLVVGAGPCGLRAAVELAMLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGSLDHISIRQLQLLLLKVALLLGVEIHWGITFTGLQPPPKKGSGWRAQLQPSPPAQLAKYEFDVLISAAGGKFVPEGFTVREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLHKDWPDTERLL... | 1.14.13.225; 1.6.3.1 | COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250|UniProtKB:Q8TDZ2}; | actin filament depolymerization [GO:0030042]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; regulation of regulated secretory pathway [GO:1903305]; sulfur oxidation [GO:0019417] | actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; hippocampal mossy fiber expansion [GO:1990026]; intercellular bridge [GO:0045171]; midbody [GO:0030496] | actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; NADPH oxidase H202-forming activity [GO:0106294]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; prote... | PF12130;PF00307;PF01494;PF00412; | 1.10.418.10;2.10.110.10;3.50.50.60; | Mical family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TDZ2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8TDZ2}. Endosome membrane {ECO:0000250|UniProtKB:Q8TDZ2}. Midbody {ECO:0000250|UniProtKB:Q8TDZ2}. | CATALYTIC ACTIVITY: Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA-COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044, ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:5834... | null | null | null | null | FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts ... | Bos taurus (Bovine) |
F1MH24 | AAK1_BOVIN | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINSVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKVITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECP... | 2.7.11.1 | null | endocytosis [GO:0006897]; positive regulation of Notch signaling pathway [GO:0045747]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of protein localization [GO:0032880] | cell leading edge [GO:0031252]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; terminal bouton [GO:0043195] | AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; Notch binding [GO:0005112]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069; | 1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family | PTM: Autophosphorylated. {ECO:0000250|UniProtKB:Q2M2I8}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11877461}; Peripheral membrane protein {ECO:0000269|PubMed:11877461}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P0C1X8}. Presynapse {ECO:0000250|UniProtKB:P0C1X8}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells,... | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000305}; CATALYTIC ACTIVITY: React... | null | null | null | null | FUNCTION: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulate... | Bos taurus (Bovine) |
F1MJR8 | TEX14_BOVIN | MSRAVHLPVPCPVQLGSLRNDSLEAQLHEYVKQGNYVKVKRILKKGIYVDAVNSLGQTALFIAALLGLTKLVDVLVDYGADPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDEKGRNPQTWALAAGKERSTVMVEFMQRCAAHMQAIIQGFSDLLKKIDSPQRLISGVPRFGGLMQGNPNGSPNRPPKAGVISAQNIYSFGFGKFYLTGGTQLAYLGSLPVIGEKEVIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELHLSTHPHCSRLRMADLLIAEQEHSSKLRHPHVLQLMAVCLSPDLEKTRLVYE... | null | null | attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint signaling [GO:0007094] | cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; midbody [GO:0030496] | ATP binding [GO:0005524]; protein kinase activity [GO:0004672] | PF12796;PF07714; | 1.25.40.20;1.10.510.10; | Protein kinase superfamily | PTM: Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-430 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Midbody {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}. | null | null | null | null | null | FUNCTION: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting th... | Bos taurus (Bovine) |
F1MLX5 | LGR4_BOVIN | MPGPLGLLCFLALGLRGSAEPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQLLDISMNNITQLPEDAFKNFPFLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSSLQSLRLDANHITSVPEDSFEGLTQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIKSLGQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELLFHSNSISVIPDGAFDGNPLLKTIHLYDNPLSFVGNSAFHNLSELHSLVIRGASMVQRFPNLTGTVR... | null | null | adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; bone remodeling [GO:0046849]; circadian regulation of gene expression [GO:0032922]; digestive tract development [GO:0048565]; epithelial cell proliferation involved in renal tubule morphogenesis [GO... | extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | protein-hormone receptor activity [GO:0016500]; transmembrane signaling receptor activity [GO:0004888] | PF00001;PF00560;PF13855;PF01462; | 1.20.1070.10;3.80.10.10; | G-protein coupled receptor 1 family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXB1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXB1}. | null | null | null | null | null | FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering t... | Bos taurus (Bovine) |
F1MMS9 | ITA3_BOVIN | MGPGPSRAAGVLRPLLGMLALMVAASNRAASAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVPDGYTNRTGAVYLCPLTAHKNDCERMDIKEKSNPNHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDARDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKDWDLSEYSYKDPEDQGNLYIGYTMQVGSAILHPTNITIVTGAPRHQHVGAVFLLSQEAGGDLRRRQVLEGTQVGAYFGSAIALADLNNDGW... | null | null | cell adhesion mediated by integrin [GO:0033627]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; positive regulation of protein localization to plasma membrane [GO:1903078] | anchoring junction [GO:0070161]; external side of plasma membrane [GO:0009897]; filopodium membrane [GO:0031527]; integrin complex [GO:0008305] | integrin binding [GO:0005178]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982] | PF01839;PF08441;PF20805;PF20806; | 1.20.5.930;2.130.10.130;2.60.40.1460;2.60.40.1510;2.60.40.1530; | Integrin alpha chain family | PTM: Phosphorylated on serine residues. {ECO:0000250}. | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:P26006}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P26006}... | null | null | null | null | null | FUNCTION: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia an... | Bos taurus (Bovine) |
F1MNN4 | FBXW7_BOVIN | MNQELLSVGSKRRRTGGSLRGNPSSSQADEEQMNRVLEEEQQQPRHQEEEHAARNGEVVGAEPRPGDQNDPQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHRNSVTNSNSIVDLPIHQRSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW... | null | null | DNA damage response [GO:0006974]; DNA repair [GO:0006281]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin recycling [GO:0010992] | chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] | phosphothreonine residue binding [GO:0050816]; ubiquitin binding [GO:0043130]; ubiquitin ligase-substrate adaptor activity [GO:1990756] | PF12937;PF00400; | 1.20.1280.50;2.130.10.10; | null | PTM: Phosphorylation at Thr-204 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation. Phosphorylated by ATM at Ser-26 in response to DNA damage, promoting recruitment to DNA damage sites and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4. {... | SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q969H0}. Chromosome {ECO:0000250|UniProtKB:Q969H0}. Note=Localizes to site of double-strand breaks following phosphorylation by ATM. {ECO:0000250|UniProtKB:Q969H0}. | null | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q969H0}. | null | null | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the ... | Bos taurus (Bovine) |
F1MSG6 | RPGF2_BOVIN | MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLCSPMEVGKKLLEWF... | null | null | adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellula... | apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; late endosome [GO:0005770]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing comple... | beta-1 adrenergic receptor binding [GO:0031697]; cAMP binding [GO:0030552]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; WW domain binding [GO:0050699] | PF00595;PF00788;PF00617;PF00618; | 2.30.42.10;2.60.120.10;1.10.840.10;1.20.870.10; | RAPGEF2 family | PTM: Ubiquitinated by NEDD4, leading to proteasomal degradation. {ECO:0000250}.; PTM: Phosphorylation by PLK2 promotes its activity. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction {ECO:0000250}. Note=Associated with the synaptic plasma membrane. Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recr... | null | null | null | null | null | FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Ra... | Bos taurus (Bovine) |
F1MWM0 | ABCA4_BOVIN | MGFARQIKLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNVNPLYSKHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTAGESPGIVSNYNNSILARVYRDFQELLMDAPESQHLGQVWRELRTLSQLMNTLRMHPERIAGRGIRIREVLKDDEMLTLFLVKNIGLSDSVVYLLVNSQVRPEQFARGVPDLMLKDIACSEALLERFLIFPQRRAAQTVRGSLCSLSQGTLQWMEDTLYANVDFFKLFHVFPRLLDSRSQGMNLRSWGRILSDMSPRIQEFIHRPSVQDLLWVTRPLVQTGGPETFTQLMGILS... | 7.6.2.1 | null | lipid transport [GO:0006869]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; photoreceptor cell maintenance [GO:0045494]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601] | endoplasmic reticulum [GO:0005783]; intracellular membrane-bounded organelle [GO:0043231]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor disc membrane [GO:0120202] | 11-cis retinal binding [GO:0005502]; ABC-type transporter activity [GO:0140359]; all-trans retinal binding [GO:0005503]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; G... | PF12698;PF00005; | 3.40.50.300; | null | PTM: N-glycosylated. {ECO:0000269|PubMed:11320094, ECO:0000269|PubMed:9092582, ECO:0000269|PubMed:9202155}.; PTM: Proteolytic cleavage by trypsin leads to a 120-kDa N-terminal fragment and a 115-kDa C-terminal fragment that are linked through disulfide bonds. {ECO:0000269|PubMed:11320094, ECO:0000269|PubMed:9092582}.; ... | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:9092582, ECO:0000269|PubMed:9202155, ECO:0000269|PubMed:9288089}. Cytoplasmic vesicle {ECO:0000269|PubMed:21721517}. Endoplasmic reticulum {ECO:0000250|UniPro... | CATALYTIC ACTIVITY: Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.; EC=7.6.2.1; Evidence={ECO:0000269|PubMed:22735453}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + ph... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=278 uM for ATP (with a purified ABCA4) {ECO:0000269|PubMed:10075733}; KM=33 uM for ATP (with ABCA4 reconstituted into brain lipid membrane) {ECO:0000269|PubMed:10075733}; KM=725 uM for ATP (reconstituted into brain lipid membrane, plus 80 uM all-trans-retinal) {ECO... | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 8. {ECO:0000269|PubMed:22735453}; | null | FUNCTION: Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-pho... | Bos taurus (Bovine) |
F1N206 | DLDH_BOVIN | MQSWSRVYCSLVKRGHFSRISHGLQGVSVVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCVEKNETLGGTCLNVGCIPSKALLNNSHFYHLAHGKDFASRGIEMSEVRLNLEKMMEQKSNAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGSTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKLVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTQ... | 1.8.1.4 | COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250|UniProtKB:P09622}; Note=Binds 1 FAD per subunit. {ECO:0000250|UniProtKB:P09622}; | branched-chain amino acid catabolic process [GO:0009083]; gastrulation [GO:0007369]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240] | acetyltransferase complex [GO:1902493]; acrosomal matrix [GO:0043159]; mitochondrial pyruvate dehydrogenase complex [GO:0005967]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252] | branched-chain alpha-keto acid dehydrogenase activity [GO:0047101]; dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]; pyruvate dehydrogenase (NAD+) activity [GO:0034604] | PF07992;PF02852; | 3.30.390.30;3.50.50.60; | Class-I pyridine nucleotide-disulfide oxidoreductase family | PTM: Tyrosine phosphorylated. {ECO:0000250|UniProtKB:Q811C4}. | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:36854377}. Nucleus {ECO:0000250|UniProtKB:P09622}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:O08749}. Note=Mainly localizes in the mitochondrion. A small fracti... | CATALYTIC ACTIVITY: Reaction=N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH; Xref=Rhea:RHEA:15045, Rhea:RHEA-COMP:10474, Rhea:RHEA-COMP:10475, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.8.1.4; Evidence={ECO... | null | null | null | null | FUNCTION: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in ... | Bos taurus (Bovine) |
F1N3B8 | OAS2_BOVIN | MGSRESHLYEKPSEKLEEFIQNHLRPSEDCQKDIDQSVDTICEVLQEPCPSLTVTGVAKGGSYGRRTVLRGNSDGILVVFFGDLEQFQDQEKRQYELLSKIWAQMKHCESTWKLAAKMELQNTNRSSRVTIQLSTKQQSITFNVLPAFNALGLSEKSSLWSYRELKRSLDMVKARPGEFSVCFTELQEKFFSNYPSKLKDLILLVKHWFQKCQEKLINSSLLPPYALELLTVYAWEQGCGAEDFDMAEGVRTVLRLIEKQEQLCVYWTVNYNFGDEIVRNILLSQLQAPRPVILDPTDPTNNVSMDNTCWLQLKHEAQNW... | 2.7.7.84 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P29728}; | defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of tumor necrosis factor productio... | cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] | 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] | PF01909;PF10421;PF18144; | 1.10.1410.20;3.30.460.10; | 2-5A synthase family | PTM: Myristoylation is not essential for its activity. {ECO:0000250|UniProtKB:P29728}.; PTM: Glycosylated. Glycosylation is essential for its activity. {ECO:0000250|UniProtKB:P29728}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P29728}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P29728}. | CATALYTIC ACTIVITY: Reaction=3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate; Xref=Rhea:RHEA:34407, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:67143; EC=2.7.7.84; Evidence={ECO:0000250|UniProtKB:P29728}; | null | null | null | null | FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L ... | Bos taurus (Bovine) |
F1N476 | ECE2_BOVIN | MSVALQELGGGGNMVEYKRATLRDEDAPETPVEGGASPDAVEAGFRKRTSRLLGLHTQLELVLAGVSLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTQRFYLSCLQVERIEELGAQPLRDLIDKIGGWNVTGPWDQDNFMEVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGQPTSTREQMRQVLELEIQLANITVPQDQRR... | 3.4.24.71 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; | brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; heart development [GO:0007507]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485] | cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] | metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] | PF01431;PF05649; | 3.40.390.10;1.10.1380.10; | Peptidase M13 family | null | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12054617}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:12054617}. | CATALYTIC ACTIVITY: Reaction=Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.; EC=3.4.24.71; Evidence={ECO:0000250|UniProtKB:P0DPD6}; | null | null | null | null | FUNCTION: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity). May play a role in amyloid-beta processing (By similarity). {ECO:... | Bos taurus (Bovine) |
F1N5C8 | ENPP6_BOVIN | MAGKLGVLLLALVLSLAQPASARRKLLVFLLDGFRADYISDEALESLPGFKEIVSRGVKVDYLTPDFPTLSYPNYYSLMTGRHCEVHQMTGNYMWDPDTNKSFDLGINRDSRLPLWWNGSEPLWVTLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKSVPTDINFVNAVSGALDVFKSGQADLAAIYYERVDVEGHHYGPSSPQRKDAVKAVDTVMAYMTKWIQERDLQDDLNVIIFSDHGMTDISWTDKVIKLDNYINLRDLQQLKGRGPVVSLWPAPGKHSEIYNKVRRVEHMTVYAKEDIPSRFYYKKGKFVSPLT... | 3.1.4.-; 3.1.4.38 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:Q8BGN3}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250|UniProtKB:Q8BGN3}; | choline metabolic process [GO:0019695]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629] | plasma membrane [GO:0005886]; side of membrane [GO:0098552] | glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872] | PF01663; | 3.30.1360.180;3.40.720.10; | Nucleotide pyrophosphatase/phosphodiesterase family | null | SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. | CATALYTIC ACTIVITY: Reaction=H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:19545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:17754, ChEBI:CHEBI:295975; EC=3.1.4.38; Evidence={ECO:0000269|PubMed:23161088}; PhysiologicalDirection=left-to-right; Xref=Rhea:R... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2000 uM for lysophosphatidylcholine {ECO:0000269|PubMed:23161088}; KM=5000 uM for glycerophosphocholine {ECO:0000269|PubMed:23161088}; KM=35 uM for p-nitrophenylphosphocholine {ECO:0000269|PubMed:23161088}; KM=5 uM for lysosphingomyelin {ECO:0000269|PubMed:23161088... | null | null | null | FUNCTION: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:23161088). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes ... | Bos taurus (Bovine) |
F1N9Y5 | KSYK_CHICK | MASNMANPANHLPYFFGNITREEAEEYLMQGGMSDGLYLLRQSRNYLGGFALSLAYGRKVHHYTIERELSGTYAIAGGKSHASPAELINYHSEEADGLICLLRKSFNRPPGVEPKTGPFEDLKENLIREYVKQTWNLQGHALEQAIISQKPQLEKLIATTAHEKMPWFHGRISREESEHRILIGSRNNGKFLIRERDSNGSYALCLLNDGKVLHYRIDRDKTGKLSIPDGKRFDTLWQLVEHYSYKPDGLLRVLSIPCPRHGSESDNVVFDTRPLPGTPSKLQTPIGAPSDDQTPFNPYVLQRARGLIGAEKGDQREALP... | 2.7.10.2 | null | adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to molecule of fungal origin [GO:0071226]; defense response to bacterium [GO:0042742];... | cytosol [GO:0005829]; early phagosome [GO:0032009]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102] | PF07714;PF00017; | 3.30.505.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, SYK/ZAP-70 subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}. Cytoplasm, cytosol {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU100... | null | null | null | null | FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet a... | Gallus gallus (Chicken) |
F1NBL0 | MUC6_CHICK | CSTWGGGHFSTFDKYQYDFTGTCNYIFATVCDESSPDFNIQFRRGLDKKIARIIIELGPSVIIVEKDSISVRSVGVIKLPYASNGIQIAPYGRSVRLVAKLMEMELVVMWNNEDYLMVLTEKKYMGKTCGMCGNYDGYELNDFVSEGKLLDTYKFAALQKMDDPSEICLSEEISIPAIPHKKYAVICSQLLNLVSPTCSVPKDGFVTRCQLDMQDCSEPGQKNCTCSTLSEYSRQCAMSHQVVFNWRTENFCSVGKCSANQIYEECGSPCIKTCSNPEYSCSSHCTYGCFCPEGTVLDDISKNRTCVHLEQCPCTLNGET... | null | null | cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; macrophage activation involved in immune response [GO:0002281]; negative regulation of cell growth [GO:0030308] | extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; supramolecular fiber [GO:0099512] | antigen binding [GO:0003823]; virion binding [GO:0046790] | PF08742;PF01826;PF00094; | 2.10.25.10; | null | PTM: N-glycosylated with N-acetylglucosamine (6.7%), N-acetylgalactosamine (0.6%), galactose (1.8%), mannose (4.6%), N-acetylneuraminic acid (1.0%) and sulfate-containing glycans (0.7%). {ECO:0000269|PubMed:21484392}. | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. | null | null | null | null | null | FUNCTION: Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6. {ECO:0000269|PubMed:5119791}. | Gallus gallus (Chicken) |
F1NCD6 | NLS1_CHICK | MAGGGGAERVRVGAAAAGLLPPSCRQPRRRESRERLSVCSKLCYAVGGAPYQTTGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPMVGFFISKTPWTRFGRLMPWIIFSTPFAVISYFLIWFVPDISTGQVMWYLIFYCIFQTLVTCFHVPYSALTMFISREQSERDSATAYRMTVEVLGTVLGTAIQGQIVGKAVTPCIENPPFLSETNFSVAIRNVNMTHYTGSLADTRNAYMVAAGVIGGLYILCAVILSVGVREKRESSELQSDEPVSFFRGLKLVMNHGAYIKLITGFLFTSLAFMLLEGNFALFCT... | null | null | carbohydrate transport [GO:0008643]; fatty acid transport [GO:0015908]; lipid transport across blood-brain barrier [GO:1990379]; lysophospholipid translocation [GO:0140329] | endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] | fatty acid transmembrane transporter activity [GO:0015245]; lysophospholipid:sodium symporter activity [GO:0051978] | PF13347; | 1.20.1250.20; | Major facilitator superfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9DA75}; Multi-pass membrane protein {ECO:0000269|PubMed:34135507}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9DA75}; Multi-pass membrane protein {ECO:0000269|PubMed:34135507}. | CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out); Xref=Rhea:RHEA:44376, ChEBI:CHEBI:29101, ChEBI:CHEBI:58168; Evidence={ECO:0000250|UniProtKB:Q9DA75}; CATALYTIC ACTIVITY: Reaction=1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glyce... | null | null | null | null | FUNCTION: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essen... | Gallus gallus (Chicken) |
F1ND48 | FBH1_CHICK | MHLTADDCEALSRSTEGLSSLTQPLNQRRSRGDVNRGLQPTHRTRTQPGAQGRQKNIMDYFKVSQRQQAVAGRTKDISIKEEVLDPFFAEDDESSISSVMETSGDSSSFLENEYMGNSRKRPLSSTAPGRLQIENDLWGEPEKKAVVVHPEHSQIKQELDDEIEIEPVPDSHYGLLGTRNWEVPQGSIEDLPDEVLRSIFAFLPVTDLYQSLSLVCRRWRIIVGDPWFIPWKKLYHQYLVKEDMALRRVEQVLQDFAITGQHKECILGLIRCVSTIPTSRNVDPSAVLQCLKGHHLFSRAEVCITNKLPHLQSKTGPEYM... | 5.6.2.4 | null | DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297] | chromatin [GO:0000785]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] | 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; double-stranded DNA binding [GO:0003690]; isomerase activity [GO:0016853]; single-stranded DNA binding [GO:0003697] | PF12937;PF00580;PF13361; | 1.20.1280.50;3.40.50.300; | Helicase family, UvrD subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NFZ0}. Chromosome {ECO:0000250|UniProtKB:Q8NFZ0}. Note=Accumulates at sites of DNA damage or replication stress. Localizes to the nucleoplasm in absence of DNA damage. {ECO:0000250|UniProtKB:Q8NFZ0}. | CATALYTIC ACTIVITY: Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.; EC=5.6.2.4; CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216... | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8NFZ0}. | null | null | FUNCTION: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange durin... | Gallus gallus (Chicken) |
F1NHE9 | KCJ12_CHICK | MTAGRVNPYSIVSSEEDGLRLTTMPGINGFGNGKIHTRRKCRNRFVKKNGQCNVEFTNMDDKPQRYIADMFTTCVDIRWRYMLLLFSLAFLVSWLLFGLIFWLIALIHGDLENPGGDDTFKPCVLQVNGFVAAFLFSIETQTTIGYGFRCVTEECPLAVFMVVVQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVAMRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRITEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEINEDSPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLASE... | null | null | potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of monoatomic ion transmembrane transport [GO:0034765] | membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] | identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242] | PF01007;PF17655;PF08466; | 1.10.287.70;2.60.40.1400; | Inward rectifier-type potassium channel family | null | SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. | null | null | null | null | null | FUNCTION: Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow in... | Gallus gallus (Chicken) |
F1NJ67 | PCFT_CHICK | MAAPSDPPTAATPPAPPPPARRCLLAPSVEPLLFLATLALGLQVPLATQYLWDRLGAERGYVGPNASSPHGCGNGSGAVDPLREEVEALVAHWNLCINLGGFFVGLFSVTLFGPWSDSVGRRPVLVLPAVGMAVQAAVYLLVMYLRLHVAYLLLGRIISGLLGDYNLILAGCFASVADSSNQRTRTFRVAILEACLGVAGMVASVGGGQWRKAEGYINPFWLVLAASLAAALYAALCLQETVKQRRAAKLLTLQHYKAVYKLYTAPEDLSSRRKLALYSLAFFLLVTVHFGTKDLYVLYELGSPLCWASDLIGYGSAASY... | null | null | folate import across plasma membrane [GO:1904447]; transmembrane transport [GO:0055085] | apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886] | folic acid binding [GO:0005542]; folic acid:proton symporter activity [GO:0140211]; methotrexate transmembrane transporter activity [GO:0015350]; transmembrane transporter activity [GO:0022857] | PF07690; | 1.20.1250.20; | Major facilitator superfamily, SLC46A family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000269|PubMed:34040256}. Apical cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000269|PubMed:34040256}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane pro... | CATALYTIC ACTIVITY: Reaction=folate(in) + H(+)(in) = folate(out) + H(+)(out); Xref=Rhea:RHEA:70159, ChEBI:CHEBI:15378, ChEBI:CHEBI:62501; Evidence={ECO:0000305|PubMed:34040256}; CATALYTIC ACTIVITY: Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out); ... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2 uM for folic acid {ECO:0000269|PubMed:34040256}; | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 5.0-5.5. {ECO:0000269|PubMed:34040256}; | null | FUNCTION: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:34040256). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (Pub... | Gallus gallus (Chicken) |
F1NPQ2 | MINP1_CHICK | MAPRRAACLLPLLVAVASAGLGGYFGTKSRYEEVNPHLAEDPLSLGPHAAASRLPAACAPLQLRAVLRHGTRYPTAGQIRRLAELHGRLRRAAAPSCPAAAALAAWPMWYEESLDRLAPRGRRDMEHLARRLAARFPALFAARRRLALASSSKHRCLQSGAAFRRGLGPSLSLGADETEIEVNDALMRFFDHCDKFVAFVEDNDTAMYQVNAFKEGPEMRKVLEKVASALCLPASELNADLVQVAFLTCSYELAIKNVTSPWCSLFSEEDAKVLEYLNDLKQYWKRGYGYDINSRSSCILFQDIFQQLDKAVDESRSSKP... | 3.1.3.62; 3.1.3.80 | null | intracellular monoatomic cation homeostasis [GO:0030003] | endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] | 3-phytase activity [GO:0016158]; 4-phytase activity [GO:0008707]; acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol bisphosphate phosphatase activity [GO:0016312]; inositol hexakisphosphate 2-phosphatase activity [GO:0052826]; inositol pentakisphosphate phosphatas... | PF00328; | 3.40.50.1240; | Histidine acid phosphatase family, MINPP1 subfamily | PTM: N-glycosylated. {ECO:0000269|PubMed:16759730, ECO:0000269|PubMed:9472008}. | SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:9472008}. Secreted {ECO:0000250|UniProtKB:Q9UNW1}. Cell membrane {ECO:0000250|UniProtKB:Q9Z2L6}. Note=Also associated with the plasma membrane in erythrocytes. {ECO:0000250|UniProtKB:Q9Z2L6}. | CATALYTIC ACTIVITY: Reaction=1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate; Xref=Rhea:RHEA:16989, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57798, ChEBI:CHEBI:58130; EC=3.1.3.62; Evidence={ECO:0000250|UniProtKB:Q9UNW1}; PhysiologicalDirection=left-to-right; Xre... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=140 uM for inositol hexakisphosphate {ECO:0000269|PubMed:16759730}; Vmax=715 nmol/min/mg enzyme with inositol hexakisphosphate as substrate {ECO:0000269|PubMed:16759730}; | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 4.5-7.5. {ECO:0000269|PubMed:16759730}; | null | FUNCTION: Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal c... | Gallus gallus (Chicken) |
F1NQJ3 | PMS2_CHICK | MEEAAPCSEPAKTIKRIDRESVHRICSGQVVLSLGTAVKELVENSLDAGATNIDVRLKDHGAELIEVSDNGGGVEEENFEGLTLKHYTSKIQDFSDLIHVETFGFRGEALSSLCALSDVTISTCHKSAKVGTRLVFDHNGKITQKAPYPRQQGTTVSIQQLFHTLPVRHKEFQRNIKKEYAKMVQILQAYCIISKGVRINCTNQVGQGKKSPVVSTTGGPNLKENIGAVFGKKQLQSLIPFVQLPPNEAVCEEYGLKSTDLPEKLYSITGFISRCDHGVGRSTTDRQFFFINQRPCDPAKVVKLVNEVYHLYNKHQYPFI... | 3.1.-.- | null | mismatch repair [GO:0006298]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; somatic hypermutation of immunogl... | cytosol [GO:0005829]; MutLalpha complex [GO:0032389]; nucleoplasm [GO:0005654] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; endonuclease activity [GO:0004519]; MutSalpha complex binding [GO:0032407]; single base insertion or deletion binding [GO:0032138]; single-stranded DNA binding [GO:0003697] | PF01119;PF13589;PF08676; | 3.30.230.10;3.30.565.10;3.30.1540.20;3.30.1370.100; | DNA mismatch repair MutL/HexB family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P54278}. | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P54278}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000250|UniProtKB:P542... | null | null | null | null | FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or contr... | Gallus gallus (Chicken) |
F1NSM7 | OC116_CHICK | MRATLFCLCLCLLGTVLPTPVSLPARARGNCPGQHQILLKGCNTKHGFYIFQYIYSHLMQKNQTQVKKEEGDHQGTIHGHWLGKVDGEAPGQGAGSSHVPEDKDSPKTHSHITPASKGEGRALRPGIGDSNSVYPTSTSVEGSGDMGSILLGEIINGEDGLPQSTHPGGPHGDGDGGNGVLVDGAVTAGRERASGSEGAGSEGGSHAPVPDQGQAGTMGTGDSAITSVTDSAITSVTKKEDVHVDTEGIDEFAYIPDVDAVTITRGQDGETHISPEDEVKIFIGRANIQVGENDSSVGSAGATSEANVIPTVVTVRPQGH... | null | null | biomineral tissue development [GO:0031214]; shell calcification [GO:0031215] | extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141] | extracellular matrix protein binding [GO:1990430] | null | null | Osteoregulin family | PTM: Asn-62 is fully glycosylated, whereas only less than 10% of Asn-293 seem to be glycosylated. {ECO:0000269|PubMed:12225802}. | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10551857}. Note=Synthesized and secreted by the granular epithelial cells of the uterus and incorporated into the eggshell matrix. {ECO:0000269|PubMed:10551857}. | null | null | null | null | null | FUNCTION: Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones. {ECO:0000269|PubMed:12225802, ECO:0000303|PubMed:10551857, ECO:0000303|PubMed:20665709}. | Gallus gallus (Chicken) |
F1NUK7 | FLRT3_CHICK | MITVPWSVFLIWTKIGLLLDMAPYSVAAKPCPSVCRCDVGFIYCNDRDLTSIPTGIPEDATNLFLQNNQINNAGIPSELKNLRRVERIFLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSQIPYLEELHLDDNSVSAVSIEDGAFRDNIYLRLLFLSRNHLSTIPWGLPKTIEELRLDDNRISTISELSLQDLTNLKRLVLDGNLLNNHGLGDKVFMNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQENHINHVPPNAFSYLRQLYRLDMSNNNLSNLPQGVFDDLDNITQLFLRNNPWHCGCKMKWVRDWL... | null | null | axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; embryonic morphogenesis [GO:0048598]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; heart development [GO:0007507]; neuron projection development [GO:0031175]; neuron pr... | axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; growth cone membrane [GO:0032584]; plasma membrane [GO:00058... | chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein homodimerization activity [GO:0042803] | PF13855; | 3.80.10.10; | null | PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8BGT1}.; PTM: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. {ECO:0000250|UniProtKB:Q8BGT1}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BGT1}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BGT1}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BGT1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BGT1}. Secreted {ECO:0000250|UniProtKB:Q8BGT1}. Cell projection, axon {EC... | null | null | null | null | null | FUNCTION: Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development (PubMed:21575622). Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial o... | Gallus gallus (Chicken) |
F1NV61 | CASP7_CHICK | MSGDQHADRSSGEKSNGDQDDTVDAKPDRSSRLSLFAKKKKNGEEEQPKSSLSNQYRIVTPTFQYNMNYKKVGKCIIINNKNFEDKTGMGTRNGTDKDAGDLSKSFRSLGFDVYTYNDRSCEDMQTLLKQAAEENHSDAACFACILLSHGEEGLIYGTDGPMAIKHLTTLFRGDKCKTLIGKPKLFFIQACRGSEFDEGIQTDSGPANDTLETDANPRYKIPVEADFLFAYSTVPGYYSWRNPGRGSWFVQSLCSVLNEHGKQLEIMQILTRVNYVVATNFESQSDDPRFSEKKQIPCVVSMLTKELYF | 3.4.22.60 | null | defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; lymphocyte apoptotic process [GO:0070227]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; proteolysis [GO:0006508] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634] | aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; RNA binding [GO:0003723] | PF00656; | 3.40.50.1460; | Peptidase C14A family | PTM: Cleavage by different proteases, such as granzyme B (GZMB), caspase-1 (CASP1), caspase-8 (CASP8) or caspase-9 (CASP9) generate the two active subunits. Its involvement in different programmed cell death processes is probably specified by the protease that activates CASP7 (By similarity). Cleaved and activated by i... | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P55210}. Nucleus {ECO:0000250|UniProtKB:P55210}. Secreted, extracellular space {ECO:0000250|UniProtKB:P97864}. Note=Following cleavage and activation by CASP1 or granzyme B (GZMB), secreted into the extracellular milieu by passing through the gasdermin-D (... | CATALYTIC ACTIVITY: Reaction=Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-.; EC=3.4.22.60; Evidence={ECO:0000250|UniProtKB:P97864}; | null | null | null | null | FUNCTION: Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:14583630). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for altern... | Gallus gallus (Chicken) |
F1NWE3 | PTPRS_CHICK | MRILPSPGMPALLSLVSLLSVLLMGCVAESPPVFIKKPVDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENIYECVAQNPHGEVTVHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSTSNGRIKQLRSGGLQIESSEETDQGKYECVASNSAGVRYSSPANLYVRELREVRRVAPRFSILPVSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKS... | 3.1.3.48 | null | negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; peptidyl-tyrosine dephosphorylation [GO:0035335]; synaptic membrane adhesion [GO:0099560] | axon [GO:0030424]; growth cone [GO:0030426]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; receptor complex [GO:0043235]; synaptic vesicle membrane [GO:0030672] | heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725] | PF00041;PF07679;PF13927;PF00102; | 2.60.40.10;3.90.190.10; | Protein-tyrosine phosphatase family, Receptor class 2A subfamily | PTM: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity). {ECO:0000250}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17178832, ECO:0000305|PubMed:17967490}; Single-pass type I membrane protein {ECO:0000305|PubMed:17967490}. Cell projection, axon {ECO:0000269|PubMed:7600997}. Perikaryon {ECO:0000250|UniProtKB:B0V2N1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membr... | CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044}; | null | null | null | null | FUNCTION: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:11865065, PubMed:17178832). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite out... | Gallus gallus (Chicken) |
F1NY98 | DSCAM_CHICK | MWMLAVALLHSISHGILTENFLSHHAFPSLLLSLHFSHPSVFSEDLHASLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFNNLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKAMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGPRFLITSTGALYILDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKASGHPTPKYRWLKDNIPWEPDSRFRQTVTGLLIENTRPSDSGNYVCE... | null | null | axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO... | dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] | cell-cell adhesion mediator activity [GO:0098632]; netrin receptor binding [GO:1990890]; protein tyrosine kinase binding [GO:1990782] | PF00041;PF07679;PF13927; | 2.60.40.10; | null | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ERC8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9ERC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9ERC8}. Synapse {ECO:0000269|PubMed:18216854}. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural ... | null | null | null | null | null | FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arbori... | Gallus gallus (Chicken) |
F1P963 | 8ODP_CANLF | MGTSRLYTLVLVLQPERVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGAKRELREESGLTVDTLHKVGQIMFEFVGEPELMDVHIFCTDSVQGTPVESDEMRPQWFQLDQIPFTDMWPDDSYWFPLLLQKKKFHGYFRFQGPNTILDYTLREVDKL | 3.6.1.-; 3.6.1.56 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q7ZWC3}; Note=Binds 2 Mg(2+) ion per subunit. {ECO:0000250|UniProtKB:Q7ZWC3}; | DNA protection [GO:0042262]; purine nucleoside catabolic process [GO:0006152] | acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965] | 2-hydroxy-ATP hydrolase activity [GO:0106377]; 2-hydroxy-dATP hydrolase activity [GO:0106378]; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; dATP diphosphatase activity [GO:0008828]; metal ion binding [G... | PF00293; | 3.90.79.10; | Nudix hydrolase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53369}. Nucleus {ECO:0000250|UniProtKB:P53369}. Nucleus membrane {ECO:0000250|UniProtKB:P53369}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P53369}. | CATALYTIC ACTIVITY: Reaction=2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+); Xref=Rhea:RHEA:31583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:63212, ChEBI:CHEBI:77897; EC=3.6.1.56; Evidence={ECO:0000250|UniProtKB:P36639}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31584; Evidence... | null | null | null | null | FUNCTION: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:29281266, PubMed:30304478, PubMed:32144205). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity). Has also a significant hydrolase activity toward 2-oxo-... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1PAA9 | CADH1_CANLF | MGPRYGGAPALLLPLLLLLQVSSGLCQEPEPCRPGFGADSYTFTVPRRHLERGRVLGRVSFEGCTGLPRTAYVSDDTRFKVGTDGVITVKRPLQLHKPEISFLVHAWDSSRRKLSTRVRLKAATHHHHHHHDAPSKTQTEVLTFPSSQHGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNRDKEIKVFYSITGQGADAPPVGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSSNGNAVEDPMEIVITVTDQNDNKPEFTQAVFQGSVTEGALPGTSVMQVTATDADDDVNTYNAAIAYSILTQDPLLPSSMMFT... | null | null | adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesi... | adherens junction [GO:0005912]; apical junction complex [GO:0043296]; catenin complex [GO:0016342]; cell-cell junction [GO:0005911]; endosome [GO:0005768]; flotillin complex [GO:0016600]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] | PF01049;PF00028;PF08758; | 2.60.40.60;4.10.900.10; | null | PTM: During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 (By similarity). Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm (... | SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250|UniProtKB:P12830}. Cell membrane {ECO:0000250|UniProtKB:P12830}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250|UniProtKB:P12830}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P12830}. Cytoplasm {ECO:0000250|Uni... | null | null | null | null | null | FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation o... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1PBJ0 | RPGF2_CANLF | MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWF... | null | null | adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellula... | apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; late endosome [GO:0005770]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing comple... | beta-1 adrenergic receptor binding [GO:0031697]; cAMP binding [GO:0030552]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; PDZ domain binding [GO:0030165]; WW domain binding [GO:0050699] | PF00595;PF00788;PF00617;PF00618; | 2.30.42.10;2.60.120.10;1.10.840.10;1.20.870.10; | RAPGEF2 family | PTM: Ubiquitinated by NEDD4, leading to proteasomal degradation. {ECO:0000250}.; PTM: Phosphorylation by PLK2 promotes its activity. {ECO:0000250}. | SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:10873669}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Late endosome {ECO:0000250}. Note=Associated with the synaptic plasma membrane. Localized diffusely in the cytoplasm before neuronal growth factor (NGF) s... | null | null | null | null | null | FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Ra... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1PJP5 | STT3A_CANLF | MTKLGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLAPLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSIYWAAKCALAYFYMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISFVGFQPVLSSEHMAAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFRSVISLVGFVLLTVGALLMLT... | 2.4.99.18 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P46977}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:B9KDD4}; | post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279] | oligosaccharyltransferase III complex [GO:0035000] | dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872] | PF02516;PF21436; | 3.40.50.12610; | STT3 family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12887896}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P46978}. | CATALYTIC ACTIVITY: Reaction=a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]; Xref=Rhea:RHEA:22980, Rhea:RHEA-COMP:9529, Rhea:RHEA-COMP:12635, Rhea:RHEA-C... | null | PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P46977}. | null | null | FUNCTION: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the firs... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1PLN3 | FTO_CANLF | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREAGSVPEDLHKEVQEAFLTLHKHGCFFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGASTKYDEAGIAAACQTFLKLNDYLQIETIQALEELACKEKSNIDAVPVCIGPDFPRVGMGSFDGQDELDIKNRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVERSAVAVYSYSCEGPEEESEDDPQLEGRDPDTWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGLPPRFSSTH... | 1.14.11.-; 1.14.11.53 | COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250|UniProtKB:Q9C0B1}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250|UniProtKB:Q9C0B1}; | DNA dealkylation involved in DNA repair [GO:0006307]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of multicellular organism growth [GO:0040014]; RNA repair [GO:0042245] | cytoplasm [GO:0005737]; nuclear speck [GO:0016607] | broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; transferase activity [GO:0016740] | PF12934;PF12933; | 2.60.120.590;1.20.58.1470; | Fto family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C0B1}. Nucleus speckle {ECO:0000250|UniProtKB:Q9C0B1}. Cytoplasm {ECO:0000250|UniProtKB:Q9C0B1}. Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'-O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (s... | CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57896, Rhea:RHEA-COMP:11518, Rhea:RHEA-COMP:11519, ChEBI:... | null | null | null | null | FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) ... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1PRN2 | MYO1D_CANLF | MAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKALNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFKVVADAMKVIGFKPEETQTVYKILAAILHLGNLKFMVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTV... | null | null | actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; early endosome to recycling endosome transport [GO:0061502]; endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle transport along actin filament [GO:0030050] | actin cytoskeleton [GO:0015629]; axon [GO:0030424]; brush border [GO:0005903]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome [GO:0005768]; microvillus [GO:0005902]; myelin sheath [GO:0043209]; myosin complex [GO:0016459]; perikaryon [GO:0043204]; plasma m... | actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904] | PF00063;PF06017; | 1.10.10.820;1.20.5.4820;1.20.58.530;3.40.850.10;1.20.120.720; | TRAFAC class myosin-kinesin ATPase superfamily, Myosin family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q63357}. Perikaryon {ECO:0000250|UniProtKB:Q63357}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63357}. Early endosome {ECO:0000269|PubMed:11208135}. Cytoplasm, cell cortex {ECO:0000269|PubMed:11208135}. Note=Colocalizes with the actin cytoskeleton in the cel... | null | null | null | null | null | FUNCTION: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (PubMed:11208135). Required for normal planar cell polarity in ciliated trac... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1PTE3 | RAB13_CANLF | MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDSFNNTYISTIGIDFKIRTVDVEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQAIKLAREHGIRFFETSAKSSTNVDEAFSSLARDILLKSGGRRSGNSHKAPGTDLKPCDKKNTSKCSLG | null | null | bicellular tight junction assembly [GO:0070830]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endothelial cell chemotaxis [GO:0035767]; establishment of Sertoli cell barrier [GO:0097368]; Golgi vesicle fusion to target membr... | bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; insulin-responsive compartment [GO:0032593]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome... | GTP binding [GO:0005525]; GTPase activity [GO:0003924] | PF00071; | 3.40.50.300; | Small GTPase superfamily, Rab family | PTM: Ubiquitinated via 'Lys-11'-linked ubiquitination on Lys-46 and Lys-58; impairing the recruitment of guanosine diphosphate (GDP) dissociation inhibitor 1/GDI1. {ECO:0000250|UniProtKB:P51153}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18094055}; Lipid-anchor {ECO:0000269|PubMed:18094055}; Cytoplasmic side {ECO:0000269|PubMed:18094055}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P51153}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, tight junction {ECO:00002... | null | null | null | null | null | FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors direct... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1PZQ5 | CCD66_CANLF | MGSKNKIAKCPIRTKQTGYILKSTQNTCIRSGKLLQKKRMGSETSLAKGEKSSMIFSPTKDLCKQYVDKDCLYVQKEISPATPTIQKTRNTINTSVVAKQKHCKKHITAENTKSGLVCLTQDQLQQILMTVNQGNKSISAIENGKEETSQDSLHLNNTSNQPKDENIMGFQKNEALSSVLDENKSTLNKNQETSKQYEQKIAIENVWKPADIFSTLGERERDRSLLEAKKAQWKKELDEQVALKKKEKEASEKWNNPWKKFESDKIVWEKFQTLGQSKTSLSSSNILSQSPSQITVVQADDYPLCRASQILEETVPLERP... | null | null | cilium assembly [GO:0060271]; microtubule bundle formation [GO:0001578]; regulation of protein localization to cilium [GO:1903564]; retina homeostasis [GO:0001895] | centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] | microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] | PF15236; | null | null | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:A2RUB6}. Cell projection, cilium {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleto... | null | null | null | null | null | FUNCTION: Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:19777273). {ECO:00... | Canis lupus familiaris (Dog) (Canis familiaris) |
F1Q4R9 | MEOX1_DANRE | MEQSASSCMRSPHTGGALWGCVRSPHSGGSGAGIQPYQQAPFALHQKHDFLAYTDFSSSCLVPAPHAYPREDRLYPETHSGYQRTEWQFSPCEPRGRGQEPCQGAAEAVGAEMDSAGGDRLAGAVTGCLEGDYSPQSVPAVDTEKKSSKRKREVTDIQDSSFKADSNCKARKERTAFTKEQLRELEAEFTHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQPASPHDLEADELDSAASPSSE | null | null | developmental pigmentation [GO:0048066]; hematopoietic stem cell differentiation [GO:0060218]; hemopoiesis [GO:0030097]; muscle cell development [GO:0055001]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sclerotome development [GO... | cytoplasm [GO:0005737]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565] | PF00046; | 1.10.10.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}. | null | null | null | null | null | FUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Re... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1Q506 | SNXAA_DANRE | MDNTSFEKREFISVWVRDPQVHKEDFWHTYISYEICLHTNSMCFRKKTSCVRRRYSEFVWLRHKLQDNALLIELPKLPPWNPFFNLNNEFHITQRMQGLQQFLEAVLQTPLLLSDSRLHLFLQSQLSIAKMDACAQGHTHYTVAQAIQRCGGEARFPVEEQHQEDSKTCCDSDCDSTTSSGLGCSIEPATLVEQDLSHNERFAHEFQATNPEAELCSSLSSSPHGHSVI | null | null | cilium assembly [GO:0060271]; heart looping [GO:0001947]; intracellular protein transport [GO:0006886]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; vesicle organization [GO:0016050] | centrosome [GO:0005813]; endosome [GO:0005768]; endosome membrane [GO:0010008] | phosphatidylinositol phosphate binding [GO:1901981] | PF00787; | 3.30.1520.10; | Sorting nexin family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. | null | null | null | null | null | FUNCTION: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. {ECO:0000269|PubMed:21844891}. | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1Q749 | DKC1_DANRE | MADTESKKEKKRKSKKISDEEVGDIQESGDFLIKPESKVASLDTSQWPLLLKNFDKLNIRTAHYTPLPHGSNPLKRGIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCVERATRLVKSQQSAGKEYVGIVRLHNALENEHQLARALECLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVLGEKDNLVTMHDVLDAQWQFDHNKDETYLRRVIFPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRYED... | 5.4.99.- | null | box H/ACA RNA 3'-end processing [GO:0000495]; definitive hemopoiesis [GO:0060216]; mRNA pseudouridine synthesis [GO:1990481]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120] | box H/ACA snoRNP complex [GO:0031429]; Cajal body [GO:0015030] | pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] | PF08068;PF01472;PF16198;PF01509; | 3.30.2350.10;2.30.130.10; | Pseudouridine synthase TruB family | null | SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O60832}. Nucleus, Cajal body {ECO:0000250|UniProtKB:P40615}. | CATALYTIC ACTIVITY: Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA; Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-COMP:11731, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; Evidence={ECO:0000250|UniProtKB:O60832}; | null | null | null | null | FUNCTION: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Pseudouridine ('psi') resi... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1Q7H8 | ZD20A_DANRE | MAPSHAVRCCQRGLSWIPVIFINLVVCWSYYAYVVELCIYTIPNVNEQVIYLVVFHAFFFMFMWSYWKTISSKPTNPSKEFCLPKAEKELYEKEERPEAQQDILKRVARELPIYTFTGSGAIRYCDRCQLIKPDRCHHCSTCDKCVLKMDHHCPWVNNCVGFSNYKFFVLFLAYSMLYCVYIAATVLQYFIKFWTNQLPDTHAKFHVLFLFFVAAMFFISILSLFSYHLWLVGKNRTTIEAFRAPVFRNGPDKNGFTLGFRKNITQVFGDQKKYWCLPIFSSLGDGYTFPTRLVTVDVEHGNIEHQTIKCTVDGQTNARP... | 2.3.1.-; 2.3.1.225 | null | protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; synaptic vesicle maturation [GO:0016188] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] | metal ion binding [GO:0046872]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439] | PF01529; | null | DHHC palmitoyltransferase family | null | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5W0Z9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5W0Z9}. Cell membrane {ECO:0000250|UniProtKB:Q5W0Z9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5W0Z9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q5W0Z9}. Endoplasmic r... | CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q5W0Z9}; Physiol... | null | null | null | null | FUNCTION: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues on protein substrates and has a preference for acyl-CoA with C16 fatty acid chains but may also utilize acyl-CoA with C14 and C18 fatty acid chains. {ECO:0000250|UniProt... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1Q8K0 | RAD54_DANRE | MRRSLAPSQVAKRKQGPDSDDEEDWEPDMEPQCKRDCREKYISPYRKPLTPLTNRPFCADGNEHEAFIRKILSKPFKIPIPNYTGVLGLRALGLRRAGVRKALHDPFEDGALVLYEPPVISAHDLIKADKEKLPVHVVVDPVLSKVLRPHQREGVKFLWDCVTGRRIENSYGCIMADEMGLGKTLQCITLIWTLLKQSPDCKPEIDKVIVVSPSSLVRNWYNEVGKWLGGRVQPVAIDGGSKDEIDSKLVNFISQQGMRIPTPILIISYETFRLHAEVLHKGKVGLVICDEGHRLKNSDNQTYLALNSMNAQRRVLISGT... | 3.6.4.12 | null | double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; reciprocal meiotic recombination [GO:0007131]; transcription-coupled nucleotide-excision repair [GO:0006283] | nucleus [GO:0005634] | ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] | PF00271;PF00176; | 3.40.50.300;1.20.120.850;3.40.50.10810; | null | PTM: Phosphorylated. Phosphorylations at Ser-566 and Ser-567 allow efficient removal of RAD51 filaments from DNA. {ECO:0000269|PubMed:30961891}. | null | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000250|UniProtKB:P32863}; | null | null | null | null | FUNCTION: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:30961891). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a d... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1Q8X5 | FERM2_DANRE | MALDGIRMPDGCYADGTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLLRKPRDPKKKKKKLEDAEEETLELEGPLLTPGSGSIYSSPGLYSKTMTPTYDSRDGSPLSPTSAWFGDSPLSEGNPSILAVSQPITSPDILVKMYKPQSLLDKAKINQGWLDSSRSLMEQDVKENEVLLLRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQY... | null | null | angiogenesis [GO:0001525]; cardiac muscle tissue morphogenesis [GO:0055008]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; cytoskeleton organization [GO:0007010]; integrin-mediated signaling pathway [GO:0007229]; regulation of cell shape [GO:0008360]; Wnt signaling pathway [GO:0016055] | cell cortex [GO:0005938]; cell surface [GO:0009986]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; I band [GO:0031674]; intercalated disc [GO:0014704]; lamellipodium membrane [GO:0031258]; nucleus [GO:0005634]; stress fiber [GO:0001725] | integrin binding [GO:0005178]; lipid binding [GO:0008289] | PF00373;PF18124;PF00169; | 2.30.29.30; | Kindlin family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.... | null | null | null | null | null | FUNCTION: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to inte... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QB30 | AMFR_DANRE | MPLLFLERFPWPSLQTYTALSALLLAGTVLSAYSTVRDSEFSSALSEGPQNEELKLENLGNVATGVLLHLITDSLFVWVMVNTACCILMLIGKVIQCIVFGPLRVSEKQHLKDKFWNFIFYKFIFIFGVLNVQRVEEVVLWCLWFSMLIFLHLMVQLCKDRFEYLSFSPTTPMSSHVRVLALLVSVLSCCGGLAVLCALAGHIHGMHTVAFMAAECLLVTVRTGHVIIRYSIHLWDLNHEGTWENKSSYIYYTDFIMELAILSLDLMHHIHMLLFGNIWLSMASLVIFMQLRHLFHEVQRRIRRHKNYLRVIDNMESRFA... | 2.3.2.36 | null | endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of plant-type hypersensitive response [GO:0034052]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent protein catabolic proc... | cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] | metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630] | PF02845;PF18442;PF13639; | 1.10.8.10;3.30.40.10; | null | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25064675}; Multi-pass membrane protein {ECO:0000255}. Note=Palmitoylation promotes localization to the peripheral endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9UKV5}. | CATALYTIC ACTIVITY: Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.; EC=2.3.2.36; Evidence={ECO:0000269|PubMed:25064675}; | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25064675}. | null | null | FUNCTION: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins (PubMed:25064675). May participate in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:25064675). Required for proper lipid homeostasis (PubMed:37119330). {ECO:00002... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QBY1 | NIPLB_DANRE | MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLYNGRIAEEVSCLLSRRDDALVSQLAHSLNQVSTEHIELKDNLGSDDPEGDVPLLLQTVLSRNPNVFREKSLMQQPMIPSYKMPQNSMHGSPASNYQQTTITPSPPSRYVQTQAGSGSRYMPQQNSPVPSPYAPQSPAGYMQYSHPPSYPQHQPIQQVSVSSPIVPSGMRNIHDNKVSGQVSGNSNHNARHCSSDEYINIVQRLGNDEGDPAMRNTSFPVRSACSPAGSEGTPKVGPRPPLILQSPPPYTSPSDTAPDLLLDSPERKKKQKRLLKEEGGK... | null | null | brain development [GO:0007420]; central nervous system development [GO:0007417]; developmental growth [GO:0048589]; digestive tract development [GO:0048565]; embryonic pectoral fin morphogenesis [GO:0035118]; embryonic viscerocranium morphogenesis [GO:0048703]; establishment of mitotic sister chromatid cohesion [GO:003... | Scc2-Scc4 cohesin loading complex [GO:0090694] | chromatin binding [GO:0003682]; chromatin loop anchoring activity [GO:0140587] | PF12765;PF12830; | 1.25.10.10; | SCC2/Nipped-B family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6KCD5}. | null | null | null | null | null | FUNCTION: May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading (PubMed:22039349). Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (B... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QC45 | XRP2_DANRE | MGCFFSKKSRRKSPKKDAALPTGDESATGNDLAETNNTALGSNSNQEAPKQYSWDKREKVDPKDFMLTGLKNETVGRLPGKLNGQQFVIQDCENCNIFVLDHSATITIDDCVNCRIVLGPVKGSVFFRDCKDIKCVVACQQFRTRDCKKMDVFLCCATQPIIESSTGMKFGCFQYYYPELAFHFKDAGLSIFNNNWSNIHDFTPVSGETNWSLLPEDAVVLDHVPLPDPESEFKSVRIATEAGRSIVPLTKGSRRTESEESCLFVFFAGDYTTANARKLIDEATAKGFVLIQTKEVSMRPEDVSRVFQNNAESLTEWITK... | null | null | determination of heart left/right asymmetry [GO:0061371]; heart looping [GO:0001947]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; post-Golgi vesicle-mediated transport [GO:0006892]; pronephros development [GO:00487... | cilium [GO:0005929]; periciliary membrane compartment [GO:1990075] | GTP binding [GO:0005525]; GTPase activator activity [GO:0005096] | PF07986; | 2.160.20.70;3.30.70.141; | TBCC family | PTM: Myristoylated on Gly-2; which may be required for membrane targeting. {ECO:0000250|UniProtKB:O75695}.; PTM: Palmitoylated on Cys-3; which may be required for plasma membrane targeting. {ECO:0000250|UniProtKB:O75695}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26034134}; Lipid-anchor {ECO:0000250|UniProtKB:O75695}; Cytoplasmic side {ECO:0000250|UniProtKB:O75695}. Cell projection, cilium {ECO:0000250|UniProtKB:O75695}. | null | null | null | null | null | FUNCTION: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, requ... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QCP6 | TAZ_DANRE | MPLEVTWPFPQCPRLGWRISSRVVMGMVGSYSYLWTKYFNSLMVHNQDVLLNLVDERPQDTPLITVCNHQSCMDDPHIWGVLKFRQLWNLNKMRWTPTASDICFTREFHSSFFSRGKCVPVVRGDGVYQKGMDFLLERLNQGEWIHIFPEGRVNMSGEFMRIKWGIGRLIAECSLHPIILPMWHIGMNDVLPNETPYIPRVGQRITVLVGKPFTVRHLVNALRAENTNPTEMRKTVTDYIQDEFRSLKAQAEALHHRLQNHT | 2.3.1.- | null | cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin metabolic process [GO:0032048]; heart development [GO:0007507]; heart looping [GO:0001947]; inner mitochondrial membrane organization [GO:0007007]; mitophagy [GO:0000423]; positive regulation of heart contraction [GO:0045823] | mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184] | PF01553; | null | Taffazin family | null | SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q16635}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q16635}; Intermembrane side {ECO:0000250|UniProtKB:Q16635}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q16635}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q16635}; Inter... | CATALYTIC ACTIVITY: Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate; Xref=Rhea:RHEA:67748, ChEBI:CHEBI:57970, ChEBI:CHEBI:58608, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence={ECO:0000250|Un... | null | PATHWAY: Phospholipid metabolism. {ECO:0000250|UniProtKB:Q16635}. | null | null | FUNCTION: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity). Its role in cellular... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QCV2 | HDA10_DANRE | MASGSALIFDEEMSRYKLLWTDPACEIEVPERLTVSYEALRTHGLAQRCKAVPVRQATEQEILLAHSEEYLEAVKQTPGMNVEELMAFSKKYNDVYFHQNIYHCAKLAAGATLQLVDSVMKREVRNGMALVRPPGHHSQRSAANGFCVFNNVAIAALYAKKNYNLNRILIVDWDVHHGQGIQYCFEEDPSVLYFSWHRYEHQSFWPNLPESDYSSVGKGKGSGFNINLPWNKVGMTNSDYLAAFFHVLLPVAYEFDPELVIVSAGFDSAIGDPEGEMCALPEIFAHLTHLLMPLAAGKMCVVLEGGYNLTSLGQSVCQTV... | 3.5.1.48; 3.5.1.62 | null | homologous recombination [GO:0035825]; macroautophagy [GO:0016236]; negative regulation of transcription by RNA polymerase II [GO:0000122]; polyamine deacetylation [GO:0106047]; regulation of tubulin deacetylation [GO:0090043]; spermidine deacetylation [GO:0106048]; swimming behavior [GO:0036269] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | acetylputrescine deacetylase activity [GO:0047609]; acetylspermidine deacetylase activity [GO:0047611]; deacetylase activity [GO:0019213]; zinc ion binding [GO:0008270] | PF00850; | 3.40.800.20; | Histone deacetylase family, HD type 2 subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969S8}. Nucleus {ECO:0000250|UniProtKB:Q969S8}. Note=Excluded from the nucleoli. {ECO:0000250|UniProtKB:Q969S8}. | CATALYTIC ACTIVITY: Reaction=H2O + N(8)-acetylspermidine = acetate + spermidine; Xref=Rhea:RHEA:23928, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:57834, ChEBI:CHEBI:58535; EC=3.5.1.48; Evidence={ECO:0000269|PubMed:28516954}; CATALYTIC ACTIVITY: Reaction=H2O + N-acetylputrescine = acetate + putrescine; Xref=Rhea:... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=90 uM for acetylcadaverine {ECO:0000269|PubMed:28516954}; KM=160 uM for acetylputrescine {ECO:0000269|PubMed:28516954}; KM=130 uM for N(8)-acetylspermidine {ECO:0000269|PubMed:28516954}; KM=180 uM for N(1),N(8)-diacetylspermidine {ECO:0000269|PubMed:28516954}; | null | null | null | FUNCTION: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Has a... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QDF8 | FXJ1A_DANRE | MLSMSSMDPWPEGSVGLEEEVVTAAAQAERLDTSTPLQCNTSLDSDNLDDSLTSLQWLQEFSILNASTGQHTSPSSHSHLMGSDAPSSPLAGDPASIGMPLTPGKPTAASFCRVPMFSALPSLVAHGHCPDEVDYKSNPHIKPPYSYATLICMAMQASKKTKITLSCIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPRQKDEPGKGGFWKIDPQYAERLLNGAYKKRRLPPVQINPALQHRLRMNAQATGVISRNLSVSPESQQLLKDFEEATSADQNWDPRLAEATMLSCWISGKGTNKRKQPYNHRTGKTP... | null | null | cerebrospinal fluid circulation [GO:0090660]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; heart jogging [GO:0003146]; heart looping [GO:0001947]; Kupffer's vesicle development [GO:0070121]; regulation ... | extracellular region [GO:0005576]; nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565] | PF00250; | 1.10.10.10; | FOXJ1 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. | null | null | null | null | null | FUNCTION: Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia. {ECO:0000269|PubMed:19011629, ECO:0000269|PubMed:19011630, ECO:0000269|PubMed:20937855}. | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QEB7 | WDR11_DANRE | MASTMIPYTVNIKLAARTLTGTLNLQNKTAVDWGWQGLIAQGCHSSILIIDPNTAQTIQVLERHKANVVKVKWSRENYHHSLSSPYSLRLASADAAGKIIVWDVVSGMAHCEIQEHSKPIQDMDWLWAQDASRDLLLAVHPPNYIVLWNGDTGTKLWKKSYAENILSFSFDPFEPSNLALLTSEGIVFITDFSHSKPPGSGGKKVYIASPHSSPAHSKPAAAQPTGAKKALNKVKVLITNEKPTAEAVTLNDCLQLSYLPSKRNHMLLLYPREILILDLELSQTVGVVAIERSGVPFIQVIPCAQRDALYCLHENGCITL... | null | null | cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; neural crest cell migration [GO:0001755]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041... | axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802] | null | null | 2.130.10.10; | null | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9BZH6}. Cytoplasm {ECO:0000250|UniProtKB:Q9BZH6}. Nucleus {ECO:0000250|UniProtKB:Q9BZH6}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:29263200}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9BZH6}. Golgi apparatus, t... | null | null | null | null | null | FUNCTION: Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QG30 | NSMA5_DANRE | MSLRESPFPNGFLEGLHAVGWGLIFPCFWFLDRLIAVCISTTLERMWRLEQECYLHPLKVVFGSILFFILFVISTPFALLGFILWAPLQAIRRPFSYHKQEQSIPMENRNARWEEMGKISFGFLTANVCLLPDGIARFNNLGHTQKRALIIGKSIVQGVTRPHIRIFVDSPSSCGTVTPSSSLIPQPNASSYGSVDASGELPDAIEVNEITPKPNCNQNSNHQKHPPRSLRTLLRDADIPMEVSALFPPSVDIVCLQEVFDKRAARKLTQALGPLYGHVLYDVGVYACHPAGSCSSFKFFNSGLFLASRFPIMEAEYRCF... | 3.1.4.12 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19429680}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:D6MZJ6}; | ceramide biosynthetic process [GO:0046513]; glycosphingolipid metabolic process [GO:0006687]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684] | cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966] | metal ion binding [GO:0046872]; phospholipase activity [GO:0004620]; sphingomyelin phosphodiesterase activity [GO:0004767] | PF03372; | 3.60.10.10; | Neutral sphingomyelinase family | null | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:19429680}; Single-pass type II membrane protein {ECO:0000305|PubMed:19429680}; Intermembrane side {ECO:0000269|PubMed:19429680}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:D6MZJ6}; Single-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence={ECO:0000269|PubMed:19429680}; PhysiologicalDirection=left-to-right; Xref=Rhea... | null | PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:19429680}. | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:19429680}; | null | FUNCTION: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000269|PubMed:19429680}. | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QGH7 | CTNB1_DANRE | MATQSDLMELEMAMDPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDDDVDNQVLYEWEQGFNQSFNQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTSGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGP... | null | null | canonical Wnt signaling pathway [GO:0060070]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; convergent extension [GO:0060026]; determination of dorsal/ventral asymmetry [GO:0048262]; dorsal/ventral pattern formation [GO:0009953]; ectoderm development [GO:0007398]; embryonic axis specification [GO:0000578... | adherens junction [GO:0005912]; catenin complex [GO:0016342]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; intercalated disc [GO:0014704]; membrane [GO:0016020]; microvillus [GO:0005902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; zonula adherens [GO:0005915] | alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; protein phosphatase binding [GO:0019903]; transcription coactivator activity [GO:0003713] | PF00514; | 1.25.10.10; | Beta-catenin family | PTM: Phosphorylation by gsk3b promotes ubiquitination and subsequent degradation by the proteasome. {ECO:0000250|UniProtKB:P35222}.; PTM: Ubiquitinated when phosphorylated by gsk3b, leading to its degradation. {ECO:0000250|UniProtKB:P35222}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10456847}. Nucleus {ECO:0000269|PubMed:15494018, ECO:0000269|PubMed:25371059, ECO:0000269|PubMed:26938059, ECO:0000269|PubMed:30467143}. Cell membrane {ECO:0000269|PubMed:15494018, ECO:0000269|PubMed:25371059, ECO:0000269|PubMed:26938059, ECO:0000269|PubMed:30361324, ... | null | null | null | null | null | FUNCTION: Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By s... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QGZ6 | MELK_DANRE | MPVDSTSELLKHYEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEKKDLGDDLPRVKIEIEAMKNLSHQHVCRLYHVIETTSKIYMVLEYCPGGELFDYIIAKDRLSEEETRVFFRQIISALAYVHSQGYAHRDLKPENLLIDEDHNLKLIDFGLCAKPKGGLGFELLTCCGSPAYAAPELIQGKAYIGSEADVWSMGVLLYALLCGFLPFDDDNCMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRRLTVKHLLDHPWVMRGYSTPVEWHSKYPLGHIDEDCITEMAVTFKQSKQRTIQLVSEWKYDQITATYL... | 2.7.11.1 | null | apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell population proliferation [GO:0008283]; erythrocyte development [GO:0048821]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; neural precursor cell proliferation [GO:0061351]; positive regulation of apoptotic process [GO:0043065]; pr... | cell cortex [GO:0005938]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF02149;PF21594;PF00069; | 3.30.310.80;1.10.510.10; | Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily | PTM: Autophosphorylated: autophosphorylation of the T-loop at Thr-169 and Ser-173 is required for activation. {ECO:0000250}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[pr... | null | null | null | null | FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis. {ECO:0000250, ECO:... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QLG5 | ADN1A_DANRE | MFQLPVNNLTRLRKARKKVKRLLSDIGLDYCKEHVEDYKDVDPDDSDDSNESHLDLCTWDPTWTKSQDYRTKQFCCSDCPFASKYFSAYKNHFRNVHREDFESRILLNCSYCTYSGNKRTLETHVRLFHMPHNVMRQGVVGPHGAPVGAKDGMRVDKPMLGDRKELPVYYCKKCTYRDRLYNVVRRHIYREHFQHVATPYLGKNSEKQVNSGEAQANSHGIHCKSCHFTPRSYEALVQHVIEFHERIGHQVTAMIGHTNVIVPRLQTNPIQRGVPITSGVRPQTPQMNRFSMPKVVGLPVGNHFKQSLAGNSVPGQPVRV... | null | null | erythrocyte maturation [GO:0043249]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] | PF19627;PF00046; | 3.30.160.60;1.10.10.60; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. | null | null | null | null | null | FUNCTION: May be involved in transcriptional regulation (PubMed:23071114, PubMed:32533114). Positively modulates wnt-beta-catenin/ctnnb1 signaling (PubMed:32533114). Required for embryonic neurogenesis (PubMed:32533114). Required for progression through late erythroid differentiation (PubMed:23071114). {ECO:0000269|Pub... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QLP1 | DHI2_DANRE | MEDFAVSFWIYIGVMSIFVGGAVKKFLAFNIGAMPSVVVWLGATLLVERLCALCMPAVLARLVLCVCCWLYFTWATPKPSLPVEDKAVFITGCDSGFGNATAKKLDAMGFEVFATVLNLEGEGAKHLRKVCSSRLTLLQVDITQPQQVQQALLDTKAKLGIRDLWGLVNNAGWCVNIGDAELSLMSNYRGCMEVNFFGTVTVTRTFLPLLRQSKGRIVTISSPSGEHPFPCLASYGASKAALNLFINTLRHELDPWGVKVSTILPSAYKTGQSSNAEYWEKQYKSLLQGLSPNLLEEYGEEYLLETKELFQNYAKTANED... | null | null | cortisol metabolic process [GO:0034650]; glucocorticoid metabolic process [GO:0008211]; multicellular organismal response to stress [GO:0033555] | intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] | 11-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0070523] | PF00106; | 3.40.50.720; | Short-chain dehydrogenases/reductases (SDR) family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH; Xref=Rhea:RHEA:53116, ChEBI:CHEBI:15378, ChEBI:CHEBI:35346, ChEBI:CHEBI:47787, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:22796344, ECO:0000269|PubMed:23042946, ECO:0000269|PubMed:27927697, ECO:00002... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=72 nM for cortisol {ECO:0000269|PubMed:22796344}; KM=147 nM for corticosterone {ECO:0000269|PubMed:22796344}; KM=206 nM for 11beta,17beta-dihydroxyandrost-4-ene-3-one {ECO:0000269|PubMed:22796344}; | PATHWAY: Steroid metabolism. {ECO:0000305}. | null | null | FUNCTION: Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:22796344, PubMed:23042946, PubMed:27927697, PubMed:33387577). Cortisol is the primary ... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QLR3 | FXR1_DANRE | MEELTVEVRGSNGAYYKGFVRDVHDDSLSISFENNWQPERQVPFSDVRLPPSADTKKEIGEGEEVEIFSRANEQEPCGWWLAKVRMMKGDFYVIEYAACDATYNEIVTFERLRPVNRNKAVTESTFFRCSVPVPEDLRAACESEQAHKEFKKAVGAIRIVYSPEKSELVVLSLSEATVKRVSLLSDIHLRSIRTKLMLMSRNQEATKHLESTKQLASAFQEEFTVREDLMGLAIGSHGSNIQQARKVPGVTAIELEEETGTFRIYGESTEAVQKARNYLEFLEDSVQIPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEG... | null | null | animal organ development [GO:0048513]; dentate gyrus development [GO:0021542]; heart development [GO:0007507]; mRNA destabilization [GO:0061157]; mRNA transport [GO:0051028]; muscle cell development [GO:0055001]; negative regulation of inflammatory response [GO:0050728]; negative regulation of long-term synaptic potent... | cytoplasmic stress granule [GO:0010494]; dendritic filopodium [GO:1902737]; dendritic spine neck [GO:0044326]; growth cone [GO:0030426]; intracellular non-membrane-bounded organelle [GO:0043232]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic d... | molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; translation regulator activity [GO:0045182] | PF05641;PF12235;PF16096;PF16097;PF00013;PF17904;PF18336; | 2.30.30.140;3.30.1370.10; | FMR1 family | PTM: Phosphorylation at Ser-447 by PAK1 promotes its activity. {ECO:0000269|PubMed:20417602}. | SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q61584}. Cytoplasm {ECO:0000250|UniProtKB:Q61584}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments. {ECO:0000250|UniProtKB:Q61584}. | null | null | null | null | null | FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as heart and muscle development (PubMed:19648401, PubMed:20417602). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes forma... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QLY4 | RORAA_DANRE | MMYFVISAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAAYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRLQQQQRDHQQQPGEAEPLTPTYGLSTNGLTELHDDLSGYMNGHTPDGTKPDSGVSSFYLDIQPSPDQSGLDINGIKPEPICDFTPGSGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHMETCQYLREELQQMTWQAFLQEEVENYQSKPREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFVRMCRAFDPQ... | null | null | negative regulation of inflammatory response [GO:0050728]; positive regulation of gene expression [GO:0010628]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; rhythmic process [GO:0048511] | nucleus [GO:0005634] | nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] | PF00104;PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family, NR1 subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35398, ECO:0000255|PROSITE-ProRule:PRU00407}. | null | null | null | null | null | FUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) (By similarity). Required for proper cerebellum development (PubMed:29656859). {ECO:0000250|UniProtKB:P35398, ECO:0000269|PubMed:29656859}. | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QN48 | FA53B_DANRE | MCVAMVIIHTKTLEKKAVDDVTSEASLQPQEPLTMSQGTALFSCGIMDSGRWADVGSVCGVQQRPVGSSLESLWDSMREAGATGGISGLLRDLSLSEASPASAAPPSKRQCRSLSCSDELGCRSSWRPQGSRVWTTVEKRRCHSGGSVQRGVFNPSGFPAMQRSSSFSLPAHSSHLEPFTHGFPFQAFSECPQTPQTLYRSHEQICPAEASSPESTPELQRRSGQSGLARSRSQPCVHNHQKIGVKRRRPADSHKQRPSLDLLKMTQKLQDFHSLSCPGFSGDDKTLPSSSPALLNDTCERAQNDSSADAPIHQSESSSE... | null | null | axon extension [GO:0048675]; fin regeneration [GO:0031101]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein import into nucleus [GO:0006606]; Wnt signaling pathway [GO:0016055] | nucleus [GO:0005634] | null | PF15242; | null | FAM53 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25183871}. | null | null | null | null | null | FUNCTION: Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) nuclear localization (PubMed:25183871). Required for appendage regeneration by regulating cell proliferation (PubMed:19014929). {ECO:0000269|PubMed:19014929, ECO:0000269|PubMed:25183871}. | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QN54 | KIF3B_DANRE | MSKSKSSESVKVVVRCRPMNEKERVANFNRVVSVDVKLGQVAVCNPRGASSHEHPKVFTFDSVYDWNSKQMELYDETFRPLVDSVLFGFNGTIFAYGQTGTGKTYTMEGVRNDPERRGVIPNSFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQARRLELKERPDTGVYVKDLSSFVTKSVREIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSELGPDGENHIRVGKLNLVDLAGSERQTKTGAQGERLKEATKINLSLSALGNVISALVDGRSTHIPYRDSKLTRLLQDSLGGNARTVMVANIGP... | null | null | cilium assembly [GO:0060271]; inner ear development [GO:0048839]; microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; neuromast development [GO:0048884]; nose development [GO:0043584]; opsin transport [GO:0036372]; photoreceptor cell development [GO:0042461]; photoreceptor cell different... | cilium [GO:0005929]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; kinesin complex [GO:0005871]; microtubule [GO:0005874] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] | PF00225; | 3.40.850.10; | TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61771}. Cell projection, cilium {ECO:0000250|UniProtKB:Q61771}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61771}. | null | null | null | null | null | FUNCTION: Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation. Required for photoreceptor development (PubMed:22308397, Pub... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QNW4 | DRC4_DANRE | MPPKRKSSPKGKTPTVVDGLSTEEMSKEQLEEHIMRLREELDREREERNYFQLERDKIHTFWEITRRHLEENKCELRNRERELEEVEERHQVEIKVYKQKVKHLLYEQQNMLSELKAESIISTKLLQDEHADLEKEQWKDMRSLKLELKQQELSSENVLKRIHLKHDEETTDLRNDFARQVQEIGSKYEKRMQKLRQEEELRRKTEIHEIEERKNTHINMLMKNHEKAFRDIRNYFSDIVYKNLDLITSLKEELKEMKKNEEKRNKEMAEVLEQNKELKESSQKAKEQVAELQKQLANYEKDKSILTRSRARLKMSDREM... | null | null | axoneme assembly [GO:0035082]; cilium movement involved in otolith formation [GO:0003355]; flagellated sperm motility [GO:0030317]; muscle cell development [GO:0055001]; otolith tethering [GO:0035889]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of smoothened signaling pathwa... | ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; motile cilium [GO:0031514] | microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] | PF13851; | null | DRC4 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O95995}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:O95995}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniPr... | null | null | null | null | null | FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dua... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QQA8 | ZN219_DANRE | MDSPPECMLALSCEPPLSPPSMPSLDHSPQFLPQSPQSTPSSPQTELYAPVSPCPLPEASLQDEEEEDEELSTPPSPTPAVALFPGELELGSPSSESSPPATPLAPFPSFGALEKAISSGQSTTCNDELDLQLFNNESIAVTGGTSSGPGLRFPCHVCGKRFRFQSILSLHARAHSLDRERRASAPYRTTHSKLQQNHESNSMIQNPLSGSFQKSMNEDMVPEEPLQTASSPQFLFEGTTALTPPLTEEAPISTSFSPLGHAQLEDNTPSPAAPAFRCHACKGKFRTASELARHVRILHNPYKCTMCPFSASQEERLAAH... | null | null | notochord development [GO:0030903]; regulation of DNA-templated transcription [GO:0006355] | nucleus [GO:0005634] | DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00096; | 3.30.160.60; | Krueppel C2H2-type zinc-finger protein family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:24155663, ECO:0000305|PubMed:24269816}. | null | null | null | null | null | FUNCTION: Transcriptional regulator (PubMed:24155663, PubMed:24269816). Recognizes and binds to the core DNA sequence motif 5'-GGGGG-3' (PubMed:24155663, PubMed:24269816). Binds to the col2a1a promoter and activates col2a1a expression (PubMed:24155663). Binds to the sncgb promoter and activates sncgb expression, as par... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QQC3 | LOL2A_DANRE | MAVSSALCIFSLLVLAQAQSELQQPKIELRLAGDKRKHYEGRLEVFYNNEWGTVCDDDFSIEAAHVACRQLGFLGAVAWSPSAKFGQGEGRIWLDNVHCTGRENSLAACPSNGFGVSDCRHSEDVGVICNQKRIPGHRFINIMNNNVETLEERVEEIRIRPISSHLKRIPITEGYVEVKERGKWRQICDEEWTPLNSRVACGMYGFPGEKNYNNKVYRSLSMRKKKNYWGFSVNCTGNEAHVSSCRLGKALEPKRNGTCGRGLPVVVSCVPGRAFAPSSSIGFRKAYRPEQPLVRLRGGANVGEGRVEVLKNGVWGTVCD... | 1.4.3.13 | COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000250|UniProtKB:Q9Y4K0}; COFACTOR: Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence={ECO:0000250|UniProtKB:Q9Y4K0}; Note=Contains 1 lysine tyrosylquinone. {ECO:0000250|UniProtKB:P33072, ECO:0000250|UniProtKB:Q9Y4K0}; | collagen fibril organization [GO:0030199]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; heterochromatin organization [GO:0070828]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell... | basement membrane [GO:0005604]; chromatin [GO:0000785]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634] | calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720] | PF01186;PF00530; | 3.10.250.10; | Lysyl oxidase family | PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000250|UniProtKB:Q9Y4K0}. | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q9Y4K0}. Nucleus {ECO:0000250|UniProtKB:Q9Y4K0}. Chromosome {ECO:0000250|UniProtKB:Q9Y4K0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y4K0}. Note=Associated with chromatin. It is unclear how LOXL2 is... | CATALYTIC ACTIVITY: Reaction=H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+); Xref=Rhea:RHEA:24544, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:131803; EC=1.4.3.13; Evidence={ECO:... | null | null | null | null | FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for e... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QQI2 | SPXN1_DANRE | MKDLRTLAAYALALLLLATFVSHSWSAPKGSFQRRNWTPQAMLYLKGTQGRRFVSEDRNEGDLYDTIRLESRSQNTENLSISKAAAFLLNILQQARDEDEPY | null | null | cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; long-chain fatty acid import into cell [GO:0044539]; negative regulation of appetite [GO:0032099]; negative regulation of eating behavior [GO:1903999]; negative regulation of heart rate [GO:0010459]; negative regulation of renal sodium excretion [G... | dense core granule [GO:0031045]; extracellular space [GO:0005615]; nucleus [GO:0005634]; transport vesicle [GO:0030133] | neuropeptide hormone activity [GO:0005184]; type 2 galanin receptor binding [GO:0031765]; type 3 galanin receptor binding [GO:0031766] | PF15171; | null | Spexin family | null | SUBCELLULAR LOCATION: [Spexin-1]: Secreted {ECO:0000250|UniProtKB:Q9BT56}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q9BT56}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q9BT56}. | null | null | null | null | null | FUNCTION: Plays a role in the regulation of food intake and energy metabolism (PubMed:29116147). May also be involved in suppressing the anxiety response by promoting the expression of serotonin-related genes such as fev, tph2 and slc6a4a (PubMed:31474838). {ECO:0000269|PubMed:29116147, ECO:0000269|PubMed:31474838}.; F... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QR43 | GLCEB_DANRE | MMRCLAARVHYKTLIVICALLSLLTVLLWNKCTSEKALRFLPRHPQPPPSPKIDSHPQQPQPPEPPPVVGGVRYEEIDCLINDDATIKGRREGSEVYMPFSWMEKYFEVYGKVVQYDGYDRFEFSHSYSKVYAQREQYHPNGVFMSFEGYNVEVRDRVKCISGVEGVPLSTQWGPQGYFYAIQIAQYGLSHYSKNLTERPPHVEVYDTAEERDSRSSAWTVPKGCSLTRVYDKTRATSVRQFSAPENSEGVSLPLGNTKDFIISFDLKFTSNGSVSVILETTEKGPPFVIHYVTTTQLILLKDRDITYGIGPRTTWTTVT... | 5.1.3.17 | null | heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] | PF06662;PF21174; | null | D-glucuronyl C5-epimerase family | null | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EPS3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9EPS3}. | CATALYTIC ACTIVITY: Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n); Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557, ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17; Evidence={ECO:0000269|PubMed:25568314, ECO:0000305|PubMed:16156897}; | null | PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. {ECO:0000305|PubMed:16156897, ECO:0000305|PubMed:25568314}.; PATHWAY: Glycan metabolism; heparin biosynthesis. {ECO:0000305|PubMed:16156897, ECO:0000305|PubMed:25568314}. | null | null | FUNCTION: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potent... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QSQ0 | DSC2L_DANRE | MRTPPRPEGLYPSPTVRYTQFMVETGHIQLLQITYPHTHSRFRMYERAHFAACLLALVLFQRAESCDPRPVLVQVPNTVPAGYFITQVTLNGCTAIPVSFTSSDPDFTVNTDGSIVTLRSLVISTKRFSVLVQDNSGLDWRVEIILSCKNEDSQKSGSVAQKRAKRRWRPLPFSVVENASPPFPKDVEMIASDSSVNYTVHYVISGQGVTEEPIGLFQLDQKTGMVRVTGPVDREKNPEFNFIARAFDQNNREVDQFLPITVMVEDVNDNAPEFTGNRFFTVEERCRAGTRVGQVNATDRDQPKTPHSLIKYILLNATDM... | null | null | adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; convergent extension involved in gastrulation [GO:0060027]; ... | adherens junction [GO:0005912]; catenin complex [GO:0016342]; desmosome [GO:0030057] | cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] | PF01049;PF00028;PF08758; | 2.60.40.60;4.10.900.10; | null | null | SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000250|UniProtKB:Q02487}. Cell membrane {ECO:0000250|UniProtKB:Q02487}; Single-pass type I membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Component of intercellular desmosome junctions (PubMed:22235774). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (PubMed:22235774). Involved in the formation and structural organization of desmosome cell-cell junctions during embryonic development (PubMe... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QU13 | ALPK2_DANRE | MTAKRVDMAAPDNLLFLDSDAVNSSPASVPIEQNEPTHVLDNQTDDSLRSMPDPHTNTALESTGLMPVPCQDETLETHSQHNEGENESSLVSTQHMDHTRLTEMTINDEKSNNWDFDISGVKENDNSTNLNPDLIHHAGTDSVMERNLNDKQTDLNHKDETFGSLMSSEVLLLKENRQQEMSQDTNLHQCSSSESTGIEYSQTANDAISDAMNSEQSPDQPFSIASNDTDKTTSECSVQTCWDTVESAATSKTQPELHDDVKDVMCESFTTSQTLNIDYLSTDISVCLADLPETDSLNILTPASTLLGILGKNNNVLKTA... | 2.7.11.1 | null | cardiac muscle cell development [GO:0055013]; epicardium morphogenesis [GO:1905223]; heart contraction [GO:0060047]; heart morphogenesis [GO:0003007]; phosphorylation [GO:0016310] | basolateral plasma membrane [GO:0016323] | ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF02816; | 2.60.40.10;3.20.200.10; | Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily | null | SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q86TB3}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q86TB3}; CATALYTI... | null | null | null | null | FUNCTION: Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000250|UniProtKB:Q86TB3, ECO:0... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QVU0 | LTK_DANRE | MDYITRQTFVKLALFIFTVLRSSCALLEKAAEDPVHPNPLQSSPAEDSDVSFCDFESPCSWTLSSHSTGGDWFITSAQQHRSSRRDTQPIRDYSTGKSEGHFLLLKPSSSHLSAGRCSFHMTSPVVLSSGPFCHLQLARFQPEPHAGNISAFVKHTDSTDIKPIDLTIKEQESDSSQWEVLEAVIGQLNEPFQVTVQYSACSSHEVGFLAFDSLELKNCVMGDDYVDLGSDCEKYSSLQCHSGGCIEKQRVCDFHTDCPEGEDEGLICSTLPLGSYCSFELGSCGWLAADTQSSWRLVSGQQLIEDTHLLGTTLKNTQGH... | 2.7.10.1 | null | developmental pigmentation [GO:0048066]; iridophore differentiation [GO:0050935]; maintenance of cell number [GO:0098727]; melanocyte differentiation [GO:0030318]; melanocyte migration [GO:0097324]; phosphorylation [GO:0016310]; pigment cell development [GO:0070285]; pigmentation [GO:0043473]; regulation of cell popula... | plasma membrane [GO:0005886]; receptor complex [GO:0043235] | ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] | PF12810;PF00629;PF07714; | 2.60.120.200;4.10.400.10;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P29376}; Single-pass type I membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000250|UniProtKB:P29376}; | null | null | null | null | FUNCTION: Receptor tyrosine kinase required for the establishment and proliferation of iridophores and their progenitors from multipotent neural crest cells (PubMed:18369445, PubMed:23821036, PubMed:26801003, PubMed:29078341, PubMed:29317532). Iridophores are the blue-tinted cells that reflect light to give fish their ... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QWA8 | SARM1_DANRE | MFLSLVVYLSKICRYLSMFSSDRLTVPEYVSSRLHNRRTAPDPRAVSPGISTDVQAVLDGSLPALRSAIRTLRSSKDTGDLEETRRAIAETFQLVEEAWVLPTVGRRVAEEICNRIRLDGGLELLLQLMQTPAVEITYESAKLLEQILVSENRDYVARMGLGVILNLTREQEDAQLARSVSGILEHMFKHTEETSAQLITNGALDTILYWCRGTDPTVLRHCAVALSNCAMYGGHRCQRLMIEKQAAEWLFPLAFSKEDELIRFHACLAVAVLAANREMEKEVVKSGTLELVEPFIASLDPDEFARNMLDSADSMQGRTA... | 3.2.2.-; 3.2.2.6 | null | cell differentiation [GO:0030154]; innate immune response [GO:0045087]; NAD catabolic process [GO:0019677]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; nervous system development [GO:0007399]; regulation of axon regeneration [GO:0048679]; response to axon injury [GO:00486... | axon [GO:0030424]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; synapse [GO:0045202] | NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; NADP+ nucleosidase activity [GO:0050135]; signaling adaptor activity [GO:0035591] | PF00536;PF07647;PF13676; | 1.25.10.10;3.40.50.10140;1.10.150.50; | SARM1 family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6SZW1}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PDS3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q6PDS3}. Synapse {ECO:0000250|UniProtKB:Q6PDS3}. Mitochondrion {ECO:0000250|UniProtKB:Q6SZW1}. Note=Associated with microtubules. {ECO:0000250|UniProtKB:... | CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000269|PubMed:28334607}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302; Evidence={E... | null | null | null | null | FUNCTION: NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:32001778). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellul... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QWW8 | KDSR_DANRE | MLLVVAAFIVAFVLLLYMISPLISPKPLKLNGAHVVVTGGSSGIGKCIAMECYKHGAFITLVARDEHKLVQAKKEVEKFAINDKQVVLCISVDVAKDYSQVESVIKQAQEKLGPVDMLVNCAGTSLSGKFEEVEVDHFKKMMEVNYLGSVYPTRAVITTMKERRMGRIMFVSSQAGQIGLFGYTAYSPSKFALRGLAEALQMEMKPYNIYVTVAYPPDTDTPGFAEENKTKPLETKLISETSGVSQPEQVAKIVVKDAVQGNFTSSFGPDGYMLSALTCGMSPVTSITEGLQQIVTMGLFRTIALFYLGSFDSIVRRCMI... | 1.1.1.102 | null | 3-keto-sphinganine metabolic process [GO:0006666]; intracellular sphingolipid homeostasis [GO:0090156]; platelet formation [GO:0030220]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid mediated signaling pathway [GO:0090520]; sphingomyelin biosynthetic process [GO:0006686] | endoplasmic reticulum membrane [GO:0005789] | 3-dehydrosphinganine reductase activity [GO:0047560] | PF00106; | 3.40.50.720; | Short-chain dehydrogenases/reductases (SDR) family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH; Xref=Rhea:RHEA:22640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57817, ChEBI:CHEBI:58299, ChEBI:CHEBI:58349; EC=1.1.1.102; Evidence={ECO:0000305|PubMed:30467204}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22642; Evi... | null | PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000305}. | null | null | FUNCTION: Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis. {ECO:0000269|PubMed:30467204}. | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QXD3 | ZH15B_DANRE | MALSRALRCCQRIFSWIPVIIISSVVLWSYYAYVFELCFVTLSNNLERVTYLLIFHVCFIMFCWTYWKAIFTPPSTPTKKFHLSYTDKERYEMEERPEVQKQILVDIAKKLPIFTRAQSGAIRFCDRCQVIKPDRCHHCSVCETCVLKMDHHCPWVNNCVGFSNYKFFLLFLSYSMIYCVFIASTVFQYFLKFWVGDLPNGPAKFHVLFLLFVALMFFVSLMFLFGYHCWLVAKNRSTLEAFSPPVFQNGPDRNGFNVGLSKNLRQVFGEHKKLWFIPVFTSQGDGHYFPLRTLRESENPLLANEEKWVEDGGSDEESAD... | 2.3.1.-; 2.3.1.225 | null | peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein localization to membrane [GO:0072657]; protein targeting to Golgi apparatus [GO:0140450] | Golgi membrane [GO:0000139]; postsynaptic density [GO:0014069] | protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; zinc ion binding [GO:0008270] | PF01529; | null | DHHC palmitoyltransferase family | PTM: Autopalmitoylated (in vitro). {ECO:0000269|PubMed:29326245}. | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:29326245}; Multi-pass membrane protein {ECO:0000269|PubMed:29326245}. Postsynaptic density {ECO:0000250|UniProtKB:Q2TGJ4}. | CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; Evidence={ECO:0000269|PubMed:29326245}; Physiolo... | null | null | null | null | FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:29326245). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). May ... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1QZ88 | E2F8_DANRE | MSSTLSEGQTLIKKSLSPSKATSTNNKGHVFVEPQTPLKNSNKASTSEAALPETLKIMGPLTTPTKVLDAPSSDPWTPTSNLKMLISAASPEIRNREKERAVDSSESENSQETEQGEEVEKLHISRKDKSLGLLCYKFLARYPNYPNPALNNGISLDDVAAELHVERRRIYDIMNVLESLNMVSRLAKNRYTWHGRVKLAQTLAVLKRAGKENRYEQLMQQIRQRSQEREEREFDLDGEEKENEEMSSFEVDGDSGLADLPGADSKAASANSRKDKSLRVMSQKFVMLFLVSSPPVVSLDVAAKILIGEDHVVDQDKNKF... | null | null | cell cycle comprising mitosis without cytokinesis [GO:0033301]; chorionic trophoblast cell differentiation [GO:0060718]; hepatocyte differentiation [GO:0070365]; lymphangiogenesis [GO:0001946]; motor neuron axon guidance [GO:0008045]; negative regulation of cytokinesis [GO:0032466]; negative regulation of DNA-templated... | RNA polymerase II transcription regulator complex [GO:0090575] | DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF02319; | 1.10.10.10; | E2F/DP family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. | null | null | null | null | null | FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represse... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R237 | TDRD6_DANRE | MCSIPGLPSKGSNVPVLITRVNLNPSCVLVEFWGNFDEDRKFAYQQLKKEIQYPRECFSESDGNPGDLCLVQVYETWYRARIVSRDSDEYSVFLIDEGRTLRAAVNTLAWGKSDFFYLPPEVEFCILANALPLSPENNWSSMALEFMKTFCGRRVNATVQDVLVAHRTFLLDIPCLSRQMFEMGFAKKLYSDQFMEFVVRSLQASTGTSDLKRISSIRTKPVEIIEQKEKQQAYMFPELQTDTVETVVITEVTSPFRIFCQLKVFSQELKKLTEQITQYYEGRVGSYFARAENLGSPCASRGSDGKWYRSVLQQVMSANN... | null | null | germ cell development [GO:0007281]; organelle assembly [GO:0070925]; P granule assembly [GO:1903863]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; regulation of oogenesis [GO:1905879]; spermatogenesis [GO:0007283] | chromatoid body [GO:0033391]; germ plasm [GO:0060293]; mitochondrial cloud [GO:0032019]; P granule [GO:0043186] | null | PF00567; | 2.30.30.140;2.40.50.90; | null | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30086300}. Note=Presents in chromatoid body (CB) of spermatids, also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB i... | null | null | null | null | null | FUNCTION: Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity) (PubMed:30086300). Requir... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R2J1 | PNX_DANRE | MHEETSNSTLQGKTSFSIADILDPAKFNGTRETREISNNRESPKTTSPTQDPSAPNIANASAAKVKSKRIRTAFTLDQLRILERSFQSSHYLSVFERHCIASALGLSETQVKIWFQNRRTKWKKELDGHGGEEQSHCAPTALTQNPIMYALPGHHANHHVHYYPQQTHYLNTSFHPQTLMMY | null | null | cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; nervous system development [GO:0007399]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357] | nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00046; | 1.10.10.60; | NK-1 homeobox family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:12642490}. | null | null | null | null | null | FUNCTION: Transcriptional repressor. Activity as a repressor is enhanced by binding to the corepressor tle3a. {ECO:0000269|PubMed:12642490}. | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R345 | DDX11_DANRE | MESKSGRFPFPFQPYPIQESFMEALYTALDQRKVGIFESPTGTGKSLSLICGALTWLRDYEEQRKQEAARLLEGQKDSDVVKEKNSNSGPPEPDWVSEFVQKKAERDMVNKLKDEELKRKKREERLEMIRHNAQLRYAMKRKADEDDEAVKLLQLSREGAEPETHSPEEEGLIVAEYESDDEATPKSRLCDDDNDDDDDLEEEHVTKIYYCSRTHSQLAQFVHEVQKSPYGDAVRLVNLGSRQNLCINPEVVRLGNVQMMNERCLEMQKNKHEKRQKASDSESKRSRGLAKATCVFSRFENLMAMKDEVLVKVRDVEQLI... | 3.6.4.12 | COFACTOR: Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250}; Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250}; | DNA duplex unwinding [GO:0032508]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; establishment of sister chromatid cohesion [GO:0034085]; nucleolar chromatin organization [GO:1990700]; regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901836]; rRNA transcription [GO:0009303] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleus [GO:0005634]; spindle pole [GO:0000922] | 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] | PF06733;PF13307; | 3.40.50.300; | DEAD box helicase family, DEAH subfamily, DDX11/CHL1 sub-subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96FC9}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96FC9}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96FC9}. Midbody {ECO:0000250|UniProtKB:Q96FC9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96FC9}... | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000250|UniProtKB:Q96FC9}; | null | null | null | null | FUNCTION: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R4C4 | PIS4A_DANRE | MAAELVEAMNMVKSFRVSDLQTLLASMGRSKSGLKQDLVGRALRLVQTEYSPELLKNVRQLYETRFPKASAWLAARRPETVAVNYPALNSSPRGTGQGTDYLNGIPKPAPPPAAEVKLVPLPFYHNLETLLPPTELVAQNSEKLQESQCVFDLTPNQVDQIRNSSELRPGMKSVQVVLRICYTDSIGVQEDQYPPNIAVKVNQSYCHVPGYYPSNKPGVEPRRPCRPVNITPWLHLSTVTNRVTITWGNFGKRYSVAVYLVRVFTSGELFNQLKHCSVENPDRCRERIQDKLRFDPESEIATTGLRVSLICPLVKMRLGV... | 2.3.2.27 | null | negative regulation of type I interferon production [GO:0032480]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase... | nucleus [GO:0005634] | DNA binding [GO:0003677]; SUMO ligase activity [GO:0061665]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] | PF14324;PF02891; | 2.60.120.780;1.10.720.30;3.30.40.10; | PIAS family | PTM: Sumoylated. Lys-35 is the main site of sumoylation. {ECO:0000250|UniProtKB:Q8N2W9}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22345667}. | CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q8N2W9}; | null | PATHWAY: Protein modification; protein sumoylation. {ECO:0000250|UniProtKB:Q8N2W9}. | null | null | FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity). May play a role as a transcriptional coregulator in various cellular pathways (By similarity). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homol... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R4U0 | TXTPB_DANRE | MSGSPKFVSPFHRPHCLSAAAPAGQAKLTHPGKAILAGGIAGGIEICITFPTEYVKTQLQLDEKANPPRYKGIVDCVKQTVQGHGVKGLYRGLSSLLYGSIPKAAVRFGVFEFLSNQMRDESGKLDSTRGLICGLGAGVAEAVVVVCPMETVKVKFIHDQTSANPKYRGFFHGVREIVRTQGLKGTYQGLTATVLKQGSNQAIRFYVMTALRNWYKGDNPNKSINPVVTGLFGAVAGAASVFGNTPLDVIKTRMQGLEAHKYKSTVDCAIKIMKYEGPAAFYKGTVPRLGRVCMDVAIVFIIYEEVVKVLNKVWKTD | null | null | mitochondrial citrate transmembrane transport [GO:0006843]; neuromuscular junction development [GO:0007528] | mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739] | antiporter activity [GO:0015297]; citrate secondary active transmembrane transporter activity [GO:0071913]; tricarboxylic acid transmembrane transporter activity [GO:0015142] | PF00153; | 1.50.40.10; | Mitochondrial carrier (TC 2.A.29) family | PTM: Possesses a short cleavable presequence, which, however, is found to be dispensable both for targeting to mitochondria and insertion into the inner membrane. However, the presequence is required to keep SLC25A1 in a soluble state and thus in an import-competent state. Mature SLC25A1 lacking the presequence is pron... | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8JZU2}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in); Xref=Rhea:RHEA:72483, ChEBI:CHEBI:15589, ChEBI:CHEBI:16947; Evidence={ECO:0000250|UniProtKB:P53007}; CATALYTIC ACTIVITY: Reaction=citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-isocitrate(out); Xref=Rhea:RHEA:7247... | null | null | null | null | FUNCTION: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate (By similarity). Required for ... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R520 | CSTN1_DANRE | MRIRGVKPFASAVGLLLGLLYAVDAAKVNKHKPWIETTYHGIVTENDDKVLLDPPLIALDKDAPLRYAGEICGFRIHGQNVPFEAVVLDKSTGEGVIRAKDKLDCELQKEHTFTIQAYDCGEGPDGGNMKKSHKATVHIQVNDVNEYSPVFKEKSYKATVIEGKKYDSIMKVEAVDADCSFQFSQICSYEIVTPDVPFTIDKDGNIKNTEKLNYGKERMYKLTVTAYDCGKNRASEDVLVKINIKPTCKPSWQGFNKRIEYEPGTGSLALFPSMHLETCEEPITSIQASIMLETNHIGKGCDRDTYSEKSLHKLCGASSG... | null | null | axon arborization [GO:0140060]; axonal transport [GO:0098930]; endocytic recycling [GO:0032456]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of synapse assembly [GO:0051965]; positive re... | axon [GO:0030424]; cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; postsynaptic membrane [GO:0045211] | amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; kinesin binding [GO:0019894]; X11-like protein binding [GO:0042988] | PF00028;PF19699; | 2.60.120.200;2.60.40.60; | Calsyntenin family | null | SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EPL2}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EPL2}. Golgi apparatus membrane {ECO:0000250|Un... | null | null | null | null | null | FUNCTION: Postsynaptic adhesion molecule involved in vesicle trafficking; required for branching of peripheral but not central axons of sensory neurons (PubMed:25009257, PubMed:25463516). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with presynaptic n... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R5H6 | BRD4_DANRE | MGDGLDAVQMSGSSSSQGQPSSQAPSSFNPNPPETSNPTRPKRQTNQLQYLLKVVLKSLWKHQFAWPFHAPVDAVKLNLPDYYKIIKNPMDMGTIKKRLESAFYTSAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKVFLTKISEMPQQEVEISTTAGKGRGRGRRDPDMNMKVGPVLEPLTASPQTRGLSNLTPGPQTRGPPQGPPTLPPQPIVQIQALPPRVPPSLPTIPLHAPQLGPPFSLGPTDCNPPAPIITAVPPPTQTALPPVHIQQSAAPPILQTPISIPNKRKSQKRKADTTTPTANDQLNESSPAES... | null | null | chromatin remodeling [GO:0006338]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymera... | chromatin [GO:0000785]; condensed chromosome [GO:0000793]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; p53 binding [GO:0002039] | PF17035;PF17105;PF00439; | 1.20.1270.220;1.20.920.10; | BET family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18498094}. Chromosome {ECO:0000269|PubMed:18498094}. Note=Associates with acetylated chromatin. | null | null | null | null | null | FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 g... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1R777 | MTA70_DANRE | MSDTWSHIQAHKKQLDSLRERLQRRRKDPTQLGTEVGSVESGSARSDSPGPAIQSPPQVEVEHPPDPELEKRLLGYLSELSLSLPTDSLTITNQLNTSESPVSHSCIQSLLLKFSAQELIEVRQPSITSSSSSTLVTSVDHTKLWAMIGSAGQSQRTAVKRKADDITHQKRALGSSPSIQAPPSPPRKSSVSLATASISQLTASSGGGGGGADKKGRSNKVQASHLDMEIESLLSQQSTKEQQSKKVSQEILELLNTSSAKEQSIVEKFRSRGRAQVQEFCDYGTKEECVQSGDTPQPCTKLHFRRIINKHTDESLGDCS... | 2.1.1.348 | null | adenosine to inosine editing [GO:0006382]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; endothelial to hematopoietic transition [GO:0098508]; flagellated sperm motility [GO:0030317]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; hematopoietic stem cell pr... | cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; mRNA (N6-adenosine)-methyltransferase activity [GO:0001734]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047] | PF05063; | null | MT-A70-like family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86U44}. Nucleus speckle {ECO:0000250|UniProtKB:Q86U44}. Cytoplasm {ECO:0000250|UniProtKB:Q86U44}. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components. {ECO:0000250|UniProtKB:Q86U44}. | CATALYTIC ACTIVITY: Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;... | null | null | null | null | FUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differ... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1RA39 | MCA2B_DANRE | MGETEEERTSQAGQLFENFIQATTCKGTLQAFSVLCRQLELNPSDHRGFYSSLKTAVTFWKAKGLWGKLDKRAGHKEYSKGRACADTRCLIIGGGPCGFRTAIELALLGAKVVVIEKRDTFSRNNVLHLWPYTIHDLRNLGAKKFYGKFCAGSIDHISIRQLQLMLLKIALIVGVEVHVNVEFVKLLEPPEDQSTDGQGWRAEIRPADNPVSDYEFDVIIGADGRRSTLDGFRRKEFRGKLAIAITANFVNRNTTAEAKVEEISGVAFIFNQKFFLELKEETGIDLENIVYYKDNTHYFVMTAKKQSLLDKGVIINDYIE... | 1.14.13.225 | COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250|UniProtKB:Q8TDZ2}; | actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; heart development [GO:0007507]; heart looping [GO:0001947]; positive regulation of transcription by RNA polymerase II [GO:0045944] | cytoplasm [GO:0005737]; nucleus [GO:0005634] | actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491] | PF12130;PF00307;PF01494;PF00412; | 1.10.418.10;2.10.110.10;3.50.50.60; | Mical family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O94851}. Cytoplasm {ECO:0000250|UniProtKB:Q8BML1}. | CATALYTIC ACTIVITY: Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA-COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044, ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:5834... | null | null | null | null | FUNCTION: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and ... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1RAX4 | STRA6_DANRE | MSAETVNNYDYSDWYENAAPTKAPVEVIPPCDPTADEGLFHICIAAISLVVMLVLAILARRQKLSDNQRGLTGLLSPVNFLDHTQHKGLAVAVYGVLFCKLVGMVLSHHPLPFTKEVANKEFWMILALLYYPALYYPLLACGTLHNKVGYVLGSLLSWTHFGILVWQKVDCPKTPQIYKYYALFGSLPQIACLAFLSFQYPLLLFKGLQNTETANASEDLSSSYYRDYVKKILKKKKPTKISSSTSKPKLFDRLRDAVKSYIYTPEDVFRFPLKLAISVVVAFIALYQMALLLISGVLPTLHIVRRGVDENIAFLLAGFN... | null | null | chordate embryonic development [GO:0043009]; retinol transport [GO:0034633]; vitamin A import into cell [GO:0071939] | plasma membrane [GO:0005886] | calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023] | PF14752; | null | null | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27563101}; Multi-pass membrane protein {ECO:0000269|PubMed:27563101}. | null | null | null | null | null | FUNCTION: Retinol transporter. Accepts retinol from the extracellular retinol-binding protein rbp4, mediates retinol transport across the cell membrane, and then transmits retinol to the cytoplasmic retinol-binding protein rbp1 (PubMed:27563101). Required for normal vitamin A homeostasis (PubMed:18316031). {ECO:0000269... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1RB95 | RNF14_DANRE | MSADQEAKEDELLALASIYDEEEFHRAESGKEGEIHLCLELPPNFKLLVKGQKSAEHNISFLPPLVLSFDLPDDYPSTSAPIFTISSKWLTRVQITALCRKLDELWEENQGNVVLFTWIQFLKEETLDFLGIQSPLEIQRSGSQPQCEPAQKHAADASGEKSKVQDLDPRAVQEVDAQTDILTQLLDFDEAQKQRVFDGKAFCCGICYSEKLGCDCLLFKECEHVYCKACIKEYFQIQIKDGKVQCLNCPEPKCASTATPTQVKLLVGEDEFARYDRLLLQSSLDLMADVVYCPRMSCCMAVMVEPDSTMGICPSCRYAF... | 2.3.2.31 | null | positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of canonical Wnt signaling pathway [GO:0060828]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein... | cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] | ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] | PF01485;PF05773; | 1.20.120.1750;2.20.25.20;3.10.110.10;3.30.40.10; | RBR family, RNF14 subfamily | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBS8}. Nucleus {ECO:0000250|UniProtKB:Q9UBS8}. | CATALYTIC ACTIVITY: Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence={ECO:0000250|UniProtKB:Q9UBS8}; | null | PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UBS8}. | null | null | FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Recruited to stall... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1RBC8 | ABCD1_DANRE | MSVYSKLPSQLKKPLVKKAVVLLIALYGVKKLSPYFFGKLKGRTSKQVKGADPLTSNGEPLVEAARKRKRSPAVNREFFDRLIRLLKILFPRLFCKELGLLGFHSLALISRTFLSIYVANLDGQIVKTIVKKDPRAFVVELTKWLLIAIPATFVNSAIRYLEGQLTLAFRTRLVTHAYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVVMFAASVAHLYSNLTKPILDVVVTCYTLIKTAESKGANTTWPSVIAGIVVALTAKVLRAFSPRFGKLVAEEARRKGDLRYMHSRIIANSEEIAFYGGHKIEMLQLQRSYNSL... | 3.1.2.-; 7.6.2.- | null | adrenal gland development [GO:0030325]; cholesterol transport [GO:0030301]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; motor behavior [GO:0061744]; oligodendrocyte development [GO:0014003]; peroxisome organization [GO:0007031]; positive regulation of myelination [... | peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | ABC-type fatty-acyl-CoA transporter activity [GO:0015607]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transporter activity [GO:0005324]; very long-chain fatty acyl-C... | PF06472;PF00005; | 1.20.1560.10;3.40.50.300; | ABC transporter superfamily, ABCD family, Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily | null | SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+); Xref=Rhea:RHEA:67072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261; Evidence={ECO:0000250|UniProtKB:P33897}; CATALYTIC ACTIVITY: Reaction=a very long-chain f... | null | null | null | null | FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA int... | Danio rerio (Zebrafish) (Brachydanio rerio) |
F1RCP1 | BECN1_DANRE | METLRFSSNTMQVSFVCQRCNQPLKLDTSFNVLDRMTIHELTAPLVMVTANKQQDSGESSSFPEETFLENKQDGVARKFIPPARMMSAESTNSFTLIGEASDGGTMENLSRRLKVTSNLFDIMSGQTDIDHPLCEECTDTLLDHLDTQLNITENECQNYKSCLELLSQLPEEEEASLLNALQQLKQEEESLIQELESIETKREAVAKELDEGRNHSQLMDTEELRYQKEYCEFKRQQLELDDDLKSVDNQMRYCQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALASKMGL... | null | null | autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to nitrogen starvation [GO:0006995]; cellular senescence [GO:0090398]; early endosome to late endosome transport [GO:0045022]; heart development [GO:0007507]; late endosome to vacuole tran... | autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; mitochondrial membrane [GO:0031966]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex,... | phosphatidylinositol 3-kinase binding [GO:0043548]; protein-macromolecule adaptor activity [GO:0030674] | PF04111;PF17675;PF15285; | 6.10.250.3110;1.10.418.40; | Beclin family | PTM: Polyubiquitinated at Lys-399 with 'Lys-48'-linkages (PubMed:28445460). 'Lys-48'-linked polyubiquitination of Lys-399 leads to degradation (PubMed:28445460). Deubiquitinated by ATXN3, leading to stabilization (PubMed:28445460). {ECO:0000305|PubMed:28445460}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14457}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endoplas... | null | null | null | null | null | FUNCTION: Plays a central role in autophagy (PubMed:24441423, PubMed:27467399, PubMed:28445460). Acts as a core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiatio... | Danio rerio (Zebrafish) (Brachydanio rerio) |
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