Entry stringlengths 6 10 | Entry Name stringlengths 5 11 | Sequence stringlengths 2 35.2k | EC number stringlengths 7 118 ⌀ | Cofactor stringlengths 38 1.77k ⌀ | Gene Ontology (biological process) stringlengths 18 11.3k ⌀ | Gene Ontology (cellular component) stringlengths 17 1.75k ⌀ | Gene Ontology (molecular function) stringlengths 24 2.09k ⌀ | Pfam stringlengths 8 232 ⌀ | Gene3D stringlengths 10 250 ⌀ | Protein families stringlengths 9 237 ⌀ | Post-translational modification stringlengths 16 8.52k ⌀ | Subcellular location [CC] stringlengths 29 6.18k ⌀ | Catalytic activity stringlengths 64 35.7k ⌀ | Kinetics stringlengths 69 11.7k ⌀ | Pathway stringlengths 27 908 ⌀ | pH dependence stringlengths 64 955 ⌀ | Temperature dependence stringlengths 70 1.16k ⌀ | Function [CC] stringlengths 17 15.3k ⌀ | Organism stringlengths 8 196 |
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O43897 | TLL1_HUMAN | MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDN... | 3.4.24.- | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|PROSITE-ProRule:PRU01211}; Note=Binds 1 zinc ion per subunit. {ECO:0000255|PROSITE-ProRule:PRU01211}; | cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; dorsal/ventral pattern formation [GO:0009953]; protein processing [GO:0016485]; skeletal system development [GO:0001501] | extracellular region [GO:0005576]; extracellular space [GO:0005615] | calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] | PF01400;PF00431;PF14670; | 3.40.390.10;2.10.25.10;2.60.120.290; | null | null | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. | null | null | null | null | null | FUNCTION: Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. | Homo sapiens (Human) |
O43900 | PRIC3_HUMAN | MFARGSRRRRSGRAPPEAEDPDRGQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVHAVPVDLERIMCRLISDFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIVRIFPVTITGAICEECGKQIGGGDIAVFASRAGLGACWHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEGRHWHMDHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGL... | null | null | cell projection organization [GO:0030030] | mitochondrion [GO:0005739]; plasma membrane [GO:0005886] | zinc ion binding [GO:0008270] | PF00412;PF06297; | 2.10.110.10; | Prickle / espinas / testin family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. Cell membrane {ECO:0000250|UniProtKB:A8WH69}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WH69}; Cytoplasmic side {ECO:0000250|UniProtKB:A8WH69}. Mitochondrion {ECO:0000269|PubMed:32516135}. Note=Recruited by VANGL2 to... | null | null | null | null | null | FUNCTION: Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core mod... | Homo sapiens (Human) |
O43903 | GAS2_HUMAN | MCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPNKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQSKSPTLKDMNPDNYLVVSASYKAKKEIK | null | null | actin crosslink formation [GO:0051764]; antral ovarian follicle growth [GO:0001547]; apoptotic process [GO:0006915]; basement membrane organization [GO:0071711]; cell cycle [GO:0007049]; initiation of primordial ovarian follicle growth [GO:0001544]; ovulation [GO:0030728]; regulation of cell cycle [GO:0051726]; regulat... | actin filament [GO:0005884]; cytosol [GO:0005829]; membrane [GO:0016020]; stress fiber [GO:0001725] | actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017] | PF00307;PF02187; | 1.10.418.10;3.30.920.20; | GAS2 family | PTM: Cleaved, during apoptosis, on a specific aspartic residue by caspases.; PTM: Phosphorylated on serine residues during the G0-G1 transition phase. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24706950}. Membrane {ECO:0000250|UniProtKB:P11862}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11862}. Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in grow... | null | null | null | null | null | FUNCTION: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {EC... | Homo sapiens (Human) |
O43909 | EXTL3_HUMAN | MTGYTMLRNGGAGNGGQTCMLRWSNRIRLTWLSFTLFVILVFFPLIAHYYLTTLDEADEAGKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKIEACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPKATRGCRLHNCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAFQATARANVYVTENADIACLYVILVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVIINLSRKSDTQNLLYNVSTGRAMVAQSTFYTVQYRPGFDLVVSPLV... | 2.4.1.223 | COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q9ES89}; | heparan sulfate proteoglycan biosynthetic process [GO:0015012]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of inflammatory response to wounding [GO:0106015]; negative regulation of keratinocyte... | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886] | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0001888]; glycosyltransferase activity [GO:0016757]; magnesium ion binding [GO:0000287]; protein-hormone receptor activity [GO:0016500] | PF03016;PF09258; | null | Glycosyltransferase 47 family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10639137}; Single-pass type II membrane protein {ECO:0000269|PubMed:10639137}. Golgi apparatus {ECO:0000269|PubMed:28132690}. Cell membrane {ECO:0000269|PubMed:19158046}. Nucleus {ECO:0000269|PubMed:19158046}. Note=Interaction with REG3A induces i... | CATALYTIC ACTIVITY: Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:16221, Rhea:RHEA-COMP:1... | null | PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. {ECO:0000269|PubMed:28132690, ECO:0000269|PubMed:28148688}. | null | null | FUNCTION: Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS) (PubMed:28132690, PubMed:28148688). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker (PubMed:11... | Homo sapiens (Human) |
O43913 | ORC5_HUMAN | MPHLENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVFVNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILIAAYLASYNP... | null | null | DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; regulation of DNA replication [GO:0006275] | chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808] | ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166] | PF13191;PF14630;PF21639; | 3.40.50.300; | ORC5 family | PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. {ECO:0000269|PubMed:3116... | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31160578}. Chromosome {ECO:0000269|PubMed:31160578}. | null | null | null | null | null | FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. {ECO:000... | Homo sapiens (Human) |
O43914 | TYOBP_HUMAN | MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK | null | null | actin cytoskeleton organization [GO:0030036]; apoptotic cell clearance [GO:0043277]; cellular defense response [GO:0006968]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; microglial cell activation involved in immune response [GO:0002282]; myeloid leukocyte activation [GO:0002274];... | cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667] | identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] | null | 1.10.287.770; | TYROBP family | PTM: Following ligand binding by associated receptors, tyrosine phosphorylated in the ITAM domain which leads to activation of additional tyrosine kinases and subsequent cell activation. {ECO:0000269|PubMed:9490415}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9655483}; Single-pass type I membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (PubMed:10604985, PubMed:9490415, PubMed:9655483). TYROBP is tyrosine-phosphorylated in the ITAM domain... | Homo sapiens (Human) |
O43915 | VEGFD_HUMAN | MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHSKKLCPIDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPCPKDLIQHPKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPF... | null | null | dopaminergic neuron differentiation [GO:0071542]; fibroblast proliferation [GO:0048144]; induction of positive chemotaxis [GO:0050930]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulat... | extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093] | chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; platelet-derived growth factor receptor binding [GO:0005161]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; vascular endothelial growth factor receptor binding [GO:0005172] | PF03128;PF00341; | 2.10.90.10; | PDGF/VEGF growth factor family | PTM: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VH... | SUBCELLULAR LOCATION: Secreted. | null | null | null | null | null | FUNCTION: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the mainten... | Homo sapiens (Human) |
O43916 | CHST1_HUMAN | MQCSWKAVLLLALASIAIQYTAIRTFTAKSFHTCPGLAEAGLAERLCEESPTFAYNLSRKTHILILATTRSGSSFVGQLFNQHLDVFYLFEPLYHVQNTLIPRFTQGKSPADRRVMLGASRDLLRSLYDCDLYFLENYIKPPPVNHTTDRIFRRGASRVLCSRPVCDPPGPADLVLEEGDCVRKCGLLNLTVAAEACRERSHVAIKTVRVPEVNDLRALVEDPRLNLKVIQLVRDPRGILASRSETFRDTYRLWRLWYGTGRKPYNLDVTQLTTVCEDFSNSVSTGLMRPPWLKGKYMLVRYEDLARNPMKKTEEIYGFL... | 2.8.2.21 | null | galactose metabolic process [GO:0006012]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; keratan sulfate metabolic process [GO:0042339]; N-acetylglucosamine metabolic process [GO:0006044]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:000679... | Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] | keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146] | PF00685; | 3.40.50.300; | Sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily | null | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.; EC=2.8.2.21; Evidence={ECO:0000269|PubMed:17690104, ECO:0000269|PubMed:9405439}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.4 mM for Galbeta1->4(6-sulfo)GlcNAcbeta1->3(6-sulfo)Galbeta1->4(6-sulfo)GlcNAc (L2L4) {ECO:0000269|PubMed:10642612}; KM=0.65 mM for NeuAcalpha2->3Galbeta1->4(6-sulfo)GlcNAcbeta1->3(6-sulfo)Galbeta1->4(6-sulfo)GlcNAc (SL2L4) {ECO:0000269|PubMed:10642612}; KM=0.38... | PATHWAY: Glycan metabolism. {ECO:0000269|PubMed:17690104}. | null | null | FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated dis... | Homo sapiens (Human) |
O43918 | AIRE_HUMAN | MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHL... | null | null | central tolerance induction to self antigen [GO:0002509]; humoral immune response [GO:0006959]; immune response [GO:0006955]; negative thymic T cell selection [GO:0045060]; peripheral T cell tolerance induction [GO:0002458]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated ... | cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674]; male germ cell nucleus [GO:0001673]; nuclear body [GO:0016604]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; translation regulator activity [GO:00451... | PF03172;PF00628;PF01342; | 3.10.390.10;3.30.40.10; | null | PTM: Phosphorylated. Phosphorylation could trigger oligomerization. {ECO:0000269|PubMed:11533054}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14974083, ECO:0000269|PubMed:26084028}. Cytoplasm {ECO:0000269|PubMed:11274163, ECO:0000269|PubMed:14974083}. Note=Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body-like structures (dots) and in a filamentous vimentin-l... | null | null | null | null | null | FUNCTION: Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Bin... | Homo sapiens (Human) |
O43920 | NDUS5_HUMAN | MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP | null | null | aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776] | mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739] | NADH dehydrogenase (ubiquinone) activity [GO:0008137] | PF10200; | null | Complex I NDUFS5 subunit family | null | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12611891}; Peripheral membrane protein {ECO:0000305}. Mitochondrion intermembrane space {ECO:0000305}. | null | null | null | null | null | FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ... | Homo sapiens (Human) |
O43921 | EFNA2_HUMAN | MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS | null | null | axon guidance [GO:0007411]; bone remodeling [GO:0046849]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]; olfactory bulb development [GO:0021772]; osteoclast differentiation [GO:0030316] | neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] | ephrin receptor binding [GO:0046875] | PF00812; | 2.60.40.420; | Ephrin family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. | null | null | null | null | null | FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signalin... | Homo sapiens (Human) |
O43924 | PDE6D_HUMAN | MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV | null | null | response to stimulus [GO:0050896]; visual perception [GO:0007601] | cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829] | GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267] | PF05351; | 2.70.50.40; | PDE6D/unc-119 family | null | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}. | null | null | null | null | null | FUNCTION: Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target protei... | Homo sapiens (Human) |
O43927 | CXL13_HUMAN | MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP | null | null | activation of GTPase activity [GO:0090630]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; B cell chemotaxis [GO:0035754]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to lipopolysaccharide [GO:0071222]; chemokine-mediat... | extracellular region [GO:0005576]; extracellular space [GO:0005615] | CCR10 chemokine receptor binding [GO:0031735]; chemokine activity [GO:0008009]; CXCR chemokine receptor binding [GO:0045236]; CXCR3 chemokine receptor binding [GO:0048248]; CXCR5 chemokine receptor binding [GO:0031724]; fibroblast growth factor binding [GO:0017134]; heparin binding [GO:0008201]; receptor ligand activit... | PF00048; | 2.40.50.40; | Intercrine alpha (chemokine CxC) family | null | SUBCELLULAR LOCATION: Secreted. | null | null | null | null | null | FUNCTION: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. | Homo sapiens (Human) |
O43929 | ORC4_HUMAN | MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHG... | null | null | DNA replication initiation [GO:0006270]; polar body extrusion after meiotic divisions [GO:0040038]; protein polymerization [GO:0051258] | chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166] | PF13191;PF14629; | 3.40.50.300; | ORC4 family | null | SUBCELLULAR LOCATION: Nucleus. | null | null | null | null | null | FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds hi... | Homo sapiens (Human) |
O43933 | PEX1_HUMAN | MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSWVEGRHFSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQSEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQE... | 3.6.4.- | null | microtubule-based peroxisome localization [GO:0060152]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-dependent protein binding [GO:0140036] | PF00004;PF17862;PF09262;PF09263; | 1.10.8.60;2.40.40.20;3.10.330.10;3.40.50.300; | AAA ATPase family | null | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16854980}. Peroxisome membrane {ECO:0000269|PubMed:11439091, ECO:0000269|PubMed:12717447, ECO:0000269|PubMed:16854980, ECO:0000269|PubMed:21362118}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes. {ECO:0000269|PubMed:127... | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:16854980}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000269|PubMed:16854980... | null | null | null | null | FUNCTION: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recogn... | Homo sapiens (Human) |
O43948 | PK4_PLAFA | MKKRIRSSYKVGSSNKYHKKNYTDNEKDKKKYRSYKEKHINEKMFDKKEFLNFLTNFNKKFMKKNSLVDHLMKMNDKAEDNYDGYNSSGSRYNNINDDGVELCGTKRYTNNKNNSDYDNYNNNNNMKNKRYSNKKHNNDNIIINNNNNKYTDERKYRNKSIKEDVDYTNDYYNIQLNNNKINNNQTKNKIDTIRNISHEKLGNNKSSSARNLSLIQTSHIPYDAPLADFLENGRFLRTFENISLIGQGGFGSVYKVSHRLEPGSPTYAVKFIYLKVSSLDNVSSRRYFREIAANRDIYSKHVVRYYTWWCEEPQFLPMHL... | 2.7.11.1 | null | negative regulation of translation [GO:0017148] | cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] | ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694] | PF00069; | 1.10.510.10; | Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily | PTM: Auto-phosphorylated. {ECO:0000269|PubMed:9371731}. | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A509AMC3}; Multi-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:9371731}; Physiologi... | null | null | null | null | FUNCTION: During the asexual blood stage, phosphorylates translation factor eIF2alpha in late schizonts resulting in protein translation inhibition (PubMed:9371731). Plays a role in trophozoite differentiation into schizonts (By similarity). {ECO:0000250|UniProtKB:C6KTB8, ECO:0000269|PubMed:9371731}. | Plasmodium falciparum |
O44074 | SDHB_ASCSU | MLRGSTSVCRSLELVTQAARYASAATAAAPTGKRIKTFEIYRFNPEEPGAKPKLQKFDVDLDKCGTMVLDALIKIKNEVDPTLTFRRSCREGICGSCAMNIAGENTLACICNIDQNTSKTTKIYPLPHMFVIKDLVPDMNLFYAQYASIQPWLQKKTKINLGEKQQYQSIKEQEKLDGLYECILCACCSASCPSYWWNADKYLGPAVLMQAYRWIIDSRDDSAAERLARMQDGFSAFKCHTIMNCTKTCPKHLNPARAIGEIKMLLTKMKTKPAPLPTPANF | 1.3.5.1 | COFACTOR: Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000255|RuleBase:RU361237}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000255|RuleBase:RU361237, ECO:0000269|PubMed:22577165, ECO:0000269|PubMed:26198225}; COFACTOR: Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000255|RuleBase:RU361237};... | respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099] | mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; plasma membrane [GO:0005886] | 2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; succinate dehydrogenase (quinone) activity [GO:0008177] | PF13085;PF13534; | 3.10.20.30;1.10.1060.10; | Succinate dehydrogenase/fumarate reductase iron-sulfur protein family | null | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|RuleBase:RU361237, ECO:0000269|PubMed:10743611, ECO:0000269|PubMed:12742584, ECO:0000269|PubMed:17933581, ECO:0000269|PubMed:22577165, ECO:0000269|PubMed:26198225, ECO:0000269|PubMed:2843227, ECO:0000269|PubMed:7822332, ECO:0000269|PubMed:8435436}; Periphe... | CATALYTIC ACTIVITY: Reaction=a ubiquinone + succinate = a ubiquinol + fumarate; Xref=Rhea:RHEA:13713, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031; EC=1.3.5.1; Evidence={ECO:0000269|PubMed:10743611, ECO:0000269|PubMed:12742584, ECO:0000269|PubMed:1... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.09 mM for fumarate (adult complex II, at 25 degrees Celsius and in anaerobic conditions) {ECO:0000269|PubMed:2843227}; KM=190 uM for succinate (free larvae complex II, at 25 degrees Celsius) {ECO:0000269|PubMed:8435436}; KM=740 uM for succinate (adult complex II,... | PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. {ECO:0000255|RuleBase:RU361237, ECO:0000269|PubMed:7822332}. | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:2843227}; | null | FUNCTION: Iron-sulfur protein (Ip) subunit of the mitochondrial electron transport chain complex II which, together with the flavoprotein (Fp) subunit forms the catalytic core of the complex (PubMed:10743611, PubMed:12742584, PubMed:17933581, PubMed:2843227, PubMed:7822332, PubMed:8435436). During the free-living egg-l... | Ascaris suum (Pig roundworm) (Ascaris lumbricoides) |
O44081 | DKC1_DROME | MADVEVRKEKKKKKIKEEPLDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLR... | 5.4.99.- | null | box H/ACA RNA 3'-end processing [GO:0000495]; germ cell development [GO:0007281]; mRNA pseudouridine synthesis [GO:1990481]; pseudouridine synthesis [GO:0001522]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; wing d... | box H/ACA snoRNP complex [GO:0031429]; nucleolus [GO:0005730] | pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] | PF08068;PF01472;PF16198;PF01509; | 3.30.2350.10;2.30.130.10; | Pseudouridine synthase TruB family | null | SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10087258, ECO:0000269|PubMed:9829824}. | CATALYTIC ACTIVITY: Reaction=a uridine in RNA = a pseudouridine in RNA; Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; | null | null | null | null | FUNCTION: Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. P... | Drosophila melanogaster (Fruit fly) |
O44126 | LEG1_HAECO | MVSQFLHWYEYNKPVPYRSLLQEKIEPGQTLIVKGSTIDESQRFTINLHSKSADFSGNDVPLHISVRFDEGKVVMNTFANGEWGKEERKSLPIKKGDSFDIRIRAHDDRFQIVIDQKEFKDYEHRLPLTSITHLSIDGDLYLNHVHWGGKYYPVPYESGIASGFPIDKTLLIFGTVEKKAKRFNINLLRRNGDIALHFNPRFDEKAVIRNALAANEWGNEEREGKMPFEKGVGFDLAIKNEAYAFQIFVNGERFTSFAHRQDPNDISGLQIQGDIELTGIQIQ | null | null | negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; positive regulation of apoptotic process [GO:0043065]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of mononuclear cell p... | membrane raft [GO:0045121] | carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936] | PF00337; | 2.60.120.200; | null | null | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10599080}. | null | null | null | null | null | FUNCTION: Binds galactose. Exerts immunomodulatory effects on host peripheral blood mononuclear cells to down-regulate host immune response (PubMed:25879191, PubMed:27337943, PubMed:28870237). Hemagglutinates human, dog, rabbit, chicken and mouse erythrocytes but does not hemagglutinate the erythrocytes of goat, its na... | Haemonchus contortus (Barber pole worm) |
O44185 | FLP13_CAEEL | MMTSLLTISMFVVAIQAFDSSEIRMLDEQYDTKNPFFQFLENSKRSDRPTRAMDSPLIRFGKRAADGAPLIRFGRAPEASPFIRFGKRAADGAPLIRFGRAPEASPFIRFGKRASPSAPLIRFGRSPSAVPLIRFGRSAAAPLIRFGRASSAPLIRFGRK | null | null | neuropeptide signaling pathway [GO:0007218]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187] | extracellular region [GO:0005576] | neuropeptide receptor binding [GO:0071855] | PF01581; | null | FARP (FMRFamide related peptide) family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. | null | null | null | null | null | FUNCTION: Probable FMRFamide-like neuropeptides (PubMed:16377032, PubMed:28094002). Binds to neuronal receptors such as dmsr-1 to promote sleep in response to cellular stress also known as stress-induced sleep (SIS) (PubMed:28094002). Plays a role in behaviors associated with SIS, acting in concert with the FMRFamide r... | Caenorhabditis elegans |
O44249 | PRP1_MANSE | MTDAKNNLLYFFDRPNEPCFMQKGEDKVVFEIPDHYYPDKYKSLSNTLSNRFGNEATKRIPIRNITLPNLEVPMQLPYNDQFSLFVPKHRTMAAKLIDIFMGMRDVEDLQSVCSYCQLRINPYMFNYCLSVAILHRPDTKGLSIPTFAETFPDKFMDSKVFLRAREVSNVVISGSRMPVNVPINYTANTTEPEQRVAYFREDIGINLHHWHWHLVYPFDSADRSIVNKDRRGELFYYMHQQIIGRYNVERMCNGLPQVKPFSDFSAPIEEGYFPKLDSQVASRTWPPRFAGSVFRNLDRTVDQVKIDVRKLFTWRDQFLE... | 1.14.18.1 | COFACTOR: Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Evidence={ECO:0000269|PubMed:19805072}; Note=Binds 2 copper ions per subunit. {ECO:0000269|PubMed:19805072}; | defense response [GO:0006952]; melanin biosynthetic process from tyrosine [GO:0006583]; positive regulation of melanization defense response [GO:0035008] | extracellular region [GO:0005576] | chloride ion binding [GO:0031404]; copper ion binding [GO:0005507]; tyrosinase activity [GO:0004503] | PF03723;PF00372;PF03722; | 1.10.1280.10;2.60.40.1520;1.20.1370.10; | Tyrosinase family | PTM: The N-terminus is blocked. {ECO:0000269|PubMed:9474780}. | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9474780}. | CATALYTIC ACTIVITY: Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504, ChEBI:CHEBI:57924; EC=1.14.18.1; CATALYTIC ACTIVITY: Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEB... | null | null | null | null | FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone. Binds to the surface of hemocytes and is ... | Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) |
O44326 | HMP2_CAEEL | MLLHSTNSYSIFTDHEVETRTSRIRSAMFPDWIPPTSAAEATNSTTSIVEMMQMPTQQLKQSVMDLLTYEGSNDMSGLSLPDLVKLMCDHDESVVARAVHRAYMLSREDPNFFNAPGFDHRSFVEALMAASKSSNVNVRRNAIGALSHMSEQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSD... | null | null | canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cortical actin cytoskeleton organization [GO:0030866]; embryo development ending in birth or egg hatchin... | adherens junction [GO:0005912]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; nucleus [GO:0005634] | alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; molecular function inhibitor activity [GO:0140678]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; transcription coactiv... | PF00514; | 1.25.10.10; | Beta-catenin family | null | SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:25850673, ECO:0000269|PubMed:9531567}. | null | null | null | null | null | FUNCTION: Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567). Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions (PubMed:26412237). {ECO:0000269|PubMed:26412237, ECO:0000269|PubMed:9531567}. | Caenorhabditis elegans |
O44342 | WBL_DROME | MMHILVTLLLVAIHSIPTTWAVTCTGCVDLDELSFEKTVERFPYSVVKFDIAYPYGEKHEAFTAFSKSAHKATKDLLIATVGVKDYGELENKALGDRYKVDDKNFPSIFLFKGNADEYVQLPSHVDVTLDNLKAFVSANTPLYIGRDGCIKEFNEVLKNYANIPDAEQLKLIEKLQAKQEQLTDPEQQQNARAYLIYMRKIHEVGYDFLEEETKRLLRLKAGKVTEAKKEELLRKLNILEVFRVHKVTKTAPEKEEL | null | null | dorsal/ventral axis specification [GO:0009950]; embryo development ending in birth or egg hatching [GO:0009792]; maternal specification of dorsal/ventral axis, oocyte, soma encoded [GO:0007313]; protein folding in endoplasmic reticulum [GO:0034975]; protein secretion [GO:0009306]; regulation of multicellular organism g... | endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788] | protein homodimerization activity [GO:0042803] | PF07749;PF07912; | 1.20.1150.12;3.40.30.10; | null | null | SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. | null | null | null | null | null | FUNCTION: Probable chaperone protein involved in dorsoventral axis patterning in early embryos. Probably acts by folding and targeting pipe (pip) into the Golgi. {ECO:0000269|PubMed:11076773, ECO:0000269|PubMed:9568717}. | Drosophila melanogaster (Fruit fly) |
O44386 | ITA3_DROME | MNAESTMFPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTSIIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVCYWVNNTVASTPQHVTRISPLRLKSEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANK... | null | null | apoptotic cell clearance [GO:0043277]; axon guidance [GO:0007411]; behavioral response to ethanol [GO:0048149]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; dorsal closure [GO:0007391]; dorsal trunk growth, open trachea... | apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020] | integrin binding [GO:0005178]; protein heterodimerization activity [GO:0046982] | PF01839;PF08441;PF20805; | 1.20.5.930;2.130.10.130;2.60.40.1460;2.60.40.1510; | Integrin alpha chain family | null | SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I membrane protein. Lateral cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Apical membrane localization in primordial dorsal-appendage cells at oogenesis stages 10B and 11. Later, weakly expressed in lateral membrane of cells surrounding ... | null | null | null | null | null | FUNCTION: Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-po... | Drosophila melanogaster (Fruit fly) |
O44406 | ERI1_CAEEL | MSADEPSPEDEKYLESLRDLLKISQEFDASNAKQNDEPEKTAVEVESAETRTDESEKSIDIPREQQLLPSERVEPLKSMVEPEYVKKVIRQMDTMTAEQLKQALMKIKVSTGGNKKTLRKRVAQYYRKENALLNRKMEPNADKTARFFDYLIAIDFECTCVEIIYDYPHEIIELPAVLIDVREMKIISEFRTYVRPVRNPKLSEFCMQFTKIAQETVDAAPYFREALQRLYTWMRKFNLGQKNSRFAFVTDGPHDMWKFMQFQCLLSNIRMPHMFRSFINIKKTFKEKFNGLIKGNGKSGIENMLERLDLSFVGNKHSGL... | 3.1.-.- | null | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; germ cell development [GO:0007281]; meiotic chromosome segregation [GO:0045132]; multicellular organismal reproductive process [GO:0048609]; negative regulation of post-transcri... | cytoplasm [GO:0005737]; nucleolus [GO:0005730] | 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723] | PF00929; | 3.30.420.10; | null | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14961122}. | null | null | null | null | null | FUNCTION: RNA exonuclease that acts as a negative regulator of RNA interference (RNAi) (PubMed:14961122). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs) (PubMed:14961122). Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediat... | Caenorhabditis elegans |
O44408 | KGB1_CAEEL | MEVDLPVHNEYDASRFHQVTIRDPIAGADSTFTIPTRYVNLSFLNAGAQGTVVMADDLVTTQRVAIKKMQQPFVMTMSAKRAYREFILLTTIKHPNIIRLLNAFTPDTSLSTFREVYLVMELMTHNLHEVIHRLRLDHKTLSFFVYQSLCAIKHLHNSGVIHRDLKPSNIVVNDRCVLKVLDFGLARKKNVDTSMRMSDYVVTRYYRAPEVILGLPYSEKVDIWSVGCIFAEMINHTVLFPGKDRIDQWTKIYSVLGTPDDHFISQLGQSAAMYVRSLPRHQARAFSEIVPDTNFLPETENPRVHLTPHVARDLLFNMLK... | 2.7.11.24 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q8WQG9}; | cellular response to arsenite ion [GO:1903843]; cellular response to toxic substance [GO:0097237]; defense response to Gram-negative bacterium [GO:0050829]; determination of adult lifespan [GO:0008340]; JNK cascade [GO:0007254]; male meiotic nuclear division [GO:0007140]; negative regulation of defense response to bact... | cytoplasm [GO:0005737]; nucleus [GO:0005634] | ATP binding [GO:0005524]; DEAD/H-box RNA helicase binding [GO:0017151]; JUN kinase activity [GO:0004705]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061... | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily | PTM: May be phosphorylated by mek-1 on Ser-198 and/or Tyr-200 (PubMed:15116070). Phosphorylation is induced upon Cu(2+) and arsenite-mediated cell stimulation and by fasting (PubMed:15116070, PubMed:23352664). {ECO:0000269|PubMed:23352664, ECO:0000305|PubMed:15116070}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17699606}. Note=Uniformly cytoplasmic in distal germline but resolves into discrete particles in developing oocytes. {ECO:0000269|PubMed:17699606}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:15116070}; CATALYTI... | null | null | null | null | FUNCTION: Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:22554143, PubMed:23352664). Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target g... | Caenorhabditis elegans |
O44411 | NOG1_CAEEL | MTSMYNFKRITCVPNAQELKDVVLSKTQRKTPTVVHRQYSIGRIRAFYARKIKFLQQTLHDKLTQIITEFPKMEEIHPFYSDLMNILYDRDHYKIALGQMNTARHLIDGIAREYVRLMKYADSLYRCKMLKRAALGRMVKLLKRQKSSFEYLEQVRQHLSRLPSIDPATRTLILCGFPNVGKSSFINNVTRADVEVQPYAFTTKALYVGHLDYRFLRWQVIDTPGILDQPLEDRNTIEMQAVTALAHLKASVLFMMDVSEQCDRSIEEQLHLFESIRPLFANKPVLIGLNKVDIRHRSDLPPEKAALLDQLEKEGIPIIE... | null | null | determination of adult lifespan [GO:0008340]; negative regulation of lipid storage [GO:0010888]; regulation of reproductive process [GO:2000241]; ribosomal large subunit biogenesis [GO:0042273] | nucleolus [GO:0005730]; nucleus [GO:0005634] | GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723] | PF06858;PF17835;PF08155; | 1.20.120.1190;3.40.50.300; | TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, NOG subfamily | null | SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:24552710}. | null | null | null | null | null | FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Has a role in regulating longevity, growth and brood size (PubMed:24552710). May regulate fat storage via the insulin/IGF pathway (PubMed:24552710). {ECO:0000250|UniProtKB:Q02892, ECO:0000269|PubMed:24552710}. | Caenorhabditis elegans |
O44437 | SMD3_DROME | MSIGVPIKVLHEAEGHIITCETITGEVYRGKLIEAEDNMNCQMTQITVTYRDGRTANLENVYIRGSKIRFLILPDMLKNAPMFKKQTGKGLGGTAGRGKAAILRAQARGRGRGGPPGGGRGTGGPPGAPGGSGGRGAWQGGPTGGRGRGGL | null | null | central nervous system development [GO:0007417]; lymph gland development [GO:0048542]; mitotic cell cycle [GO:0000278]; mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; neuron differentiation [GO:0030182]; oogenesis [GO:0048477]; peripheral nervous system development [GO:0007422]; pol... | catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; pole plasm [GO:0045495]; precatalytic spliceosome [GO:0071011]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; splice... | RNA binding [GO:0003723] | PF01423; | 2.30.30.100; | SnRNP core protein family | PTM: Methylated on arginine residues by Art5 and Art7; methylation is not required for assembly and biogenesis of snRNPs. {ECO:0000269|PubMed:18369183}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62318}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62318}. | null | null | null | null | null | FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). {ECO:0000250|UniProtKB:P62318}. | Drosophila melanogaster (Fruit fly) |
O44476 | RNZ2_CAEEL | MLGAIARKTVENRILVSRHLISSTSCLFKDNNEELLESIKERIARNRRILQKHSSSHLKAREVNASISNLRQSMAAVQKKQKAAHEPPANSIVNIPSQVSIEVLGNGTGLLRACFILRTPLKTYMFNCPENACRFLWQLRIRSSSVVDLFITSANWDNIAGISSILLSKESNALSTRLHGAMNIKHFLECIRPFQDSDYGSCKYPSQVEERPYTMENYEDAGLKVTYIPLSPPLNIGSNNEKSKNVKVNNVDIAFLIEMKEAARRIDTMKLMELKVPKGPLIGKLKSGEAVTLPDGRTIQPDQVFSSDKVEGDKPLLLVT... | 3.1.26.11 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305}; | germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; nematode larval development [GO:0002119]; positive regulation of vulval development [GO:0040026] | mitochondrion [GO:0005739]; nucleus [GO:0005634] | 3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872] | PF12706; | 3.60.15.10; | RNase Z family | null | SUBCELLULAR LOCATION: [Isoform a]: Mitochondrion {ECO:0000269|PubMed:35451962}.; SUBCELLULAR LOCATION: [Isoform b]: Nucleus {ECO:0000269|PubMed:35451962}. Note=Accumulates in the nucleus upon mitochondrial stress. {ECO:0000269|PubMed:35451962}. | CATALYTIC ACTIVITY: Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.; EC=3.1.26.11; Evidence={ECO:0000305|PubMed:35451962}; | null | null | null | null | FUNCTION: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity (PubMed:35451962). Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Involved in germline proliferation (PubMed:14729485). May be required for both mitosis and meiosis in germ... | Caenorhabditis elegans |
O44514 | PMK3_CAEEL | MASVPSSSSLPVSHVRRHEDVSTPSAPPTKRSNNQSQPPESYEPNTWLQQQREQEQQKKLAAENIKKQSIEATGNNEMVGEEEEDILSKPCGPHKRRFQFVMIRNITFAIPEGYDVEPNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNIICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKIDSYTNLADMWSLGCIAA... | 2.7.11.24 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11703092}; | axon regeneration [GO:0031103]; behavioral response to nicotine [GO:0035095]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; p38MAPK cascade [GO:0038066]; phosphorylation [GO:0016310]; positive regulation of axon extension involved in regeneration [GO:0048691]; regulation of 3'-UTR-mediated ... | axon [GO:0030424]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634] | ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00069; | 1.10.510.10; | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily | PTM: Dually phosphorylated on Thr-285 and Tyr-287, which activates the enzyme. {ECO:0000250}. | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11703092, ECO:0000269|PubMed:26657059}. Cytoplasm {ECO:0000269|PubMed:26657059}. Cell projection, axon {ECO:0000269|PubMed:26657059}. Cell projection, dendrite {ECO:0000269|PubMed:26657059}. Cell projection, cilium {ECO:0000269|PubMed:26657059}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000269|PubMed:11703092}; CATALYTI... | null | null | null | null | FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets (PubMed:11703092). Involved in axon regeneration after injury, probably downstream of dlk-1 and mkk-4 and upstream of mak-2 (PubMed:19737525, PubMed:21670305). May phosphorylate mak-2 (PubMed:19... | Caenorhabditis elegans |
O44516 | EFN4_CAEEL | MKQFFEFLITTFLLLGLAAADEHIVYWNSTNSLFRNRQPTIEVRMGDVVRFVCPDNEEGRNDGEYLIVYEVTEFAMDDCALESHSREVIRCAPEGTAEKVLRTQQLSGGRREDWKKQKVPPKNVAQLIRQLNPIPNGKEYQPGQTYYYMTTSTGKANGTNHRMYGLCESQNMRLSMKVSASQPHPTRRAPTRRQEDFVTTASAELMGGQEDEDSDNDNAHLLPRDLEGSTNPKFRRPSQLETAGVENQQFMKVVQMAQAGKTGTFENEKEAIAQKSSEKDGWHPVNVQYVADLMNNAYQNADERISYQRDFEIHEENDLA... | null | null | axon guidance [GO:0007411]; cell migration involved in gastrulation [GO:0042074]; embryo development ending in birth or egg hatching [GO:0009792]; ephrin receptor signaling pathway [GO:0048013]; morphogenesis of embryonic epithelium [GO:0016331]; nematode male tail tip morphogenesis [GO:0045138]; regulation of axon gui... | axon [GO:0030424]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] | ephrin receptor binding [GO:0046875] | PF00812; | 2.60.40.420; | Ephrin family | PTM: May undergo proteolysis by metalloprotease sup-17 to give rise to a soluble form. {ECO:0000305|PubMed:26903502}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. | null | null | null | null | null | FUNCTION: Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis (PubMed:12679110). In early embryonic development, involved in ventral closure of the epidermis (PubMed:12403719). During male tail morphogenesis, regulates precursor cell sorting together with mab-20 ... | Caenorhabditis elegans |
O44518 | CYFIP_CAEEL | MNANVTVDDAISNVNLLDTLAIPDDLPDIEARALPLLYRSNFDTNFEDRSAFVTGIAKYSEEATRHAQFNDMLSEGLQHAANMYTWRCCSRAVPMAKSNDQPNRTEINEMVVEVLKPEVSKLGSFMRFTLTAIQRFCEEVRRLCHSEKRRDFVSEAYLLTLGRFINMFAVLDELKNMKASIKNDFSTFRRASQFLTAMSDTQAVHDMQNLSMFLATQNKIKDDLKLQMKTIEGYEELLCDVVNICAHMYEHQLYLSPNEKHMFVKVIAFSLFLMDGDAANVAKLDQKKRLSISRLDKIFKTLEVVPLYGDMQIQPFAFVR... | null | null | axon guidance [GO:0007411]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; embryonic body morphogenesis [GO:0010172]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of egg-laying behavior [GO:1901046]; regulation of actin fil... | cell junction [GO:0030054]; neuron projection [GO:0043005]; SCAR complex [GO:0031209]; synapse [GO:0045202] | RNA 7-methylguanosine cap binding [GO:0000340]; small GTPase binding [GO:0031267] | PF07159;PF05994; | null | CYFIP family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11877381}. Note=Enriched at cell boundaries. {ECO:0000269|PubMed:11877381}. | null | null | null | null | null | FUNCTION: Required for initial steps of body morphogenesis (PubMed:11877381). May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the... | Caenorhabditis elegans |
O44548 | KNL2_CAEEL | MGDTEIVPLRVQNVLDSEIIRLNLWSMKFNATSFKLEGFVRNEEGTMMQKVCSEFICRRFTSTLLFDVSGRFFDLVGQIDREYQQKMGMPSRIIDEFSNGIPENWADLIYSCMSANQRSALRPIQQAPKEPIRTRTEPIVTLADETELTGGCQKNSENEKERNRREREEQQTKERERRLEEEKQRRDAEAEAERRRKEEEELEEANYTLRAPKSQNGEPITPIRFTRGHDNGGAKKVFIFEQTPVRKQGPIASSTPQQKQRLADGANNQIPPTQKSQDSVQAVQPPPPRPAARNAQFASDADLFAVPKAPPSKSVRNLAA... | null | null | cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321] | chromosome, centromeric region [GO:0000775]; kinetochore [GO:0000776]; nucleus [GO:0005634] | null | PF21506;PF09133; | 1.10.10.1900; | KNL2 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17339379}. Chromosome, centromere {ECO:0000269|PubMed:17339379}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17339379}. Note=Requires hcp-3 for chromatin localization. {ECO:0000269|PubMed:17339379}. | null | null | null | null | null | FUNCTION: Required for the recruitment of hcp-3, hcp-4, knl-1, bub-1 and lin-53 to kinetochores, kinetochore assembly, chromosome condensation and chromosome segregation in meiosis and mitosis. {ECO:0000269|PubMed:17339379, ECO:0000269|PubMed:26904949}. | Caenorhabditis elegans |
O44712 | AHR_CAEEL | MYASKRRQRNFKRVRDPPKQLTNTNPSKRHRERLNGELETVAMLLPYDSSTISRLDKLSVLRLAVSFLQCKAHFQACLHNSQFLSAGFPMSTHSYSYQPHPPIPFSNKVPTIFDLRIGTPMLDPEESNFEEISLKSLGGFILVLNDNGEIYYASENVENYLGFHQSDVLHQPVYDLIHSEDRDDIRQQLDSNFHIPTSSASNQFDVFAPQNSKYLERNVNARFRCLLDNTCGFLRIDMRGKLMSLHGLPSSYVMGRTASGPVLGMICVCTPFVPPSTSDLASEDMILKTKHQLDGALVSMDQKVYEMLEIDETDLPMPLY... | null | null | behavior [GO:0007610]; intracellular receptor signaling pathway [GO:0030522]; negative regulation of locomotion [GO:0040013]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to xenobiotic stimulus [GO:0009410]; xenobiotic metabolic process [GO:00... | aryl hydrocarbon receptor complex [GO:0034751]; nuclear aryl hydrocarbon receptor complex [GO:0034753]; nucleus [GO:0005634] | DNA binding [GO:0003677]; nuclear receptor activity [GO:0004879]; protein heterodimerization activity [GO:0046982]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976] | PF00989;PF08447; | 4.10.280.10;3.30.450.20; | null | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | null | null | null | null | null | FUNCTION: Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carb... | Caenorhabditis elegans |
O44740 | MEI2_CAEEL | MSGLDDRKKLTHAKNRKPLNDIPKSAENRPNTRSTSSRRGAEKDVPITFIGSSRTVKADLPEFTNTRSRRPLHSESKKELSRNPVSRGEEHSSSLPKSSPESSVSVMSSNASLWSACTEEVNKIGVCAKRESRNLRVYKMKSFTSNMEQILSNDNQLAPTVIRILNSRNSWCLNSCHACLTFIMENITSDNYGKRSACLKALASITNSLLDTIIGFASTKTRRIGVDVVAEERAAKATECIHNFRKIVKNRDKIYKQIDQETIYKLDAILERLKKVSSHK | null | null | cell division [GO:0051301]; embryo development ending in birth or egg hatching [GO:0009792]; meiotic spindle disassembly [GO:0051229]; meiotic spindle organization [GO:0000212]; microtubule depolymerization [GO:0007019] | condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; male pronucleus [GO:0001940]; microtubule [GO:0005874]; spindle pole [GO:0000922] | null | null | null | null | null | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10809666}. Note=Localized to the spindle poles and condensed chromatin during female meiosis. Also localized to the polar body. Correct localization requires mei-1. | null | null | null | null | null | FUNCTION: Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germl... | Caenorhabditis elegans |
O44743 | LE607_CAEEL | MDQDFDLDEGAGQFNLKTTLMMFTSNDSQNDDGIWSPGSPYQALEDPSFLDKHFVSDPDRYTADELYSALEKMDGKSDLIGMDDMDNDNCYSLSPPDSGSLPISPASTSPSSYHSSGGEDLMDCYPSIDILQQASEELLYSKDDDYEICSSGPLLAYTNANSVATSAVHQNQQQQQRRLNQAGFPHQNSNGLVRFKSSQPRVLNPASISLNAPSSSFNPQSTSSTPATSSSSSSSTNGGFVKSSTGERRKYPPLRLDEEEIKLCKKEGICLPDFFPLTKAEERDLKRIRRKIRNKRSAQTSRKRKQDYIEQLEDRVSEST... | null | null | negative regulation of protein kinase C signaling [GO:0090038]; regulation of cell size [GO:0008361]; regulation of distal tip cell migration [GO:1903354]; regulation of establishment of cell polarity [GO:2000114]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase I... | chromatin [GO:0000785]; nucleus [GO:0005634] | DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] | PF00170; | 1.20.5.170; | BZIP family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. | null | null | null | null | null | FUNCTION: Probable transcription factor, required during migration of the gonadal distal tip cells (DTC) (PubMed:24811939). Probably regulates cell adhesion of DTCs via modulation of expression of genes involved in integrin-mediated adhesion, including tln-1, src-1, and integrin pat-2 (PubMed:24811939). Modulates expre... | Caenorhabditis elegans |
O44750 | XPP_CAEEL | MTALEKLAKLRSLFHSERVLALTSSKPMVAYLLPSTDAHHSEYLADYDFRVKFLSGFSGSNAYVVVTDREALLWTDGRYFTQAGNQLDSNSWKLMKQGQPDSITVVDWLVRELERGSVIGFDPTLSTFDAGSKTFKRLKAAGLQPVSIPGNLVDEFWTDRPRLAGEPVVVLDVEDTGLTTSKKVENLREKLKQKKCDAAVFTLLDDVMWLLNIRGSDIPYNPLAYSYLFVAMREIHVFIDNEKLDEKSRAHFHKSNVSIHPYGEVYSWISNWLKAKEASKEPHMVYLTPETNYAIGSIIGEENSMVDTSLVQTAKATKND... | 3.4.11.9 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:25905034}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:25905034}; | proteolysis [GO:0006508]; proteolysis involved in protein catabolic process [GO:0051603] | cytoplasm [GO:0005737] | metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] | PF01321;PF16189;PF00557;PF16188; | 3.90.230.10;3.40.350.10; | Peptidase M24B family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11606206}. | CATALYTIC ACTIVITY: Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; Evidence={ECO:0000269|PubMed:11606206}; | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=45 uM for bradykinin {ECO:0000269|PubMed:11606206}; | null | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7-8. {ECO:0000269|PubMed:11606206}; | null | FUNCTION: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11606206, PubMed:25905034). Has activity towards the flp-9 neuropeptide KPSFVRF-amide (PubMed:11606206). {ECO:0000269|PubMed:11606206, ECO:0000269|PubMed:25905034}. | Caenorhabditis elegans |
O44757 | LIN59_CAEEL | MHGAGEQQQRYRYNARSDEQHHHPSTSSHQYQQQGARQMHQMHPIQATLMCTPTTTSAAASTSSSGGSNSSGGSGGHRQQGNILRIGNSIKIGDNILEPAGTLVFSQADGTPWTGQRIVVNGSTHAVVKANLFPIGTTPPVLNMQSNQNWYMNQPSGTVPMSSNAPATTSSATPDSGIQSVPTSPPSPSYAMMNDVDIGDHDDEEDDDGPADFTDMPLLKPVDEDDDCYDVPCTSEGPPPNNSNPAITTIPSSCSTPAPPKESLPTGMNVEEWGSFLIASNMDREEIVRRLMAHDPEMAKAIAMRIRELSAEESKKKKDM... | 2.1.1.- | null | ectodermal cell fate specification [GO:0001715]; egg-laying behavior [GO:0018991]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract development [GO:0048566]; locomotion [GO:0040011]; methylation [GO:0032259]; nematode larval development [GO:0002119]; nematode male tail tip morp... | chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] | chromatin binding [GO:0003682]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872] | PF01426;PF00628;PF00856; | 2.30.30.490;2.170.270.10;3.30.40.10; | Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; | null | null | null | null | FUNCTION: Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state... | Caenorhabditis elegans |
O44783 | SPY_DROME | MDRRNGGDPLAPPRPPKLLPRVHRPRAPEPTLSGVDHNAGATASALASGASSAAPVAIHNNNSQQQLSISAAASNNNTISIIPASPDFDDYQIHHLTFLPQRPSSLSRNSSTASSTTATGISVSGSGSVSGSSSSFTRRRPPAPVPLNNSISNNNNNSINNNFLSHFQSAEPASNALGQPPASPVTLAQPRPESERLTNEYVDTPLQHATRSQHPAGQQDNGQTTTHHLLLLPQRNQHLHLQQHQQHLQQQQQQQQQQQQQQHLQHQQNQQHARLATTTQATSVGSDHTDGLLHSHLQNSTTKPPASKQPAPPRLGMGLG... | null | null | animal organ development [GO:0048513]; branching involved in open tracheal system development [GO:0060446]; compound eye morphogenesis [GO:0001745]; dorsal/ventral axis specification, ovarian follicular epithelium [GO:0008069]; glial cell development [GO:0021782]; lamellocyte differentiation [GO:0035171]; muscle cell d... | apical part of cell [GO:0045177]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886] | null | PF05210; | null | Sprouty family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10089881, ECO:0000269|PubMed:9458049}; Peripheral membrane protein {ECO:0000269|PubMed:10089881, ECO:0000269|PubMed:9458049}; Cytoplasmic side {ECO:0000269|PubMed:10089881, ECO:0000269|PubMed:9458049}. | null | null | null | null | null | FUNCTION: Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follic... | Drosophila melanogaster (Fruit fly) |
O44836 | MMPB_CAEEL | MTKWSPNGNPLSTIYLILSLFTLAHTAPTTQHSRTTTQLRLEDEDGGGGVDEDSIHFVKGQMEKYGYLKGIDHSSPQEFRQALMFFQEVLEVEQTGNVDEMTVEAASKPRCTQTDVRQEQTKRTKRFTLSKRAKWAHASGQSVTLKWYISDYTSDIDRLETRKVVEKAFKLWSSQSYIKNEKKVTLTFQEASSKDEADINILWAEGNHGDEHDFDGANGKIEGNKKENVLAHTFFPGYARPLNGDIHFDDAEDWEIDVDQVGHGSNKRFFPYVLAHEIGHALGLDHSQKADALMHPYYKNVPINEIQLDIDDKCGVIWNY... | 3.4.24.- | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:P03956}; | collagen catabolic process [GO:0030574]; defense response to Gram-negative bacterium [GO:0050829]; determination of adult lifespan [GO:0008340]; ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; extracellular matrix organization [GO:0030198]; heat acclimation [GO:0010286]; larval development [GO:0002164]; neg... | extracellular matrix [GO:0031012]; extracellular space [GO:0005615] | metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] | PF00413; | 3.40.390.10; | Peptidase M10A family | null | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:24957743}. | null | null | null | null | null | FUNCTION: Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:24957743). Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol (PubMed:20600277, PubMed:24957743). {ECO:0000269|... | Caenorhabditis elegans |
O44857 | NEPL2_CAEEL | MRPDEEDGTTKSPGSRWTRIWAIIALILLILFLLVLGAAIYFYINYKDSSDVCLSPGCIKTASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDENDEPYDYETSAVGKAKYFYNLCLNESEILDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLDADRTRATLDAKEIIDFETALANITMADEHRHDIAELYTKITLGEMRRSLPHFNWPLFFNRMFKDLHEKNG... | 3.4.24.- | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:P08473}; Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:P08473}; | olfactory learning [GO:0008355]; protein processing [GO:0016485]; regulation of chemotaxis [GO:0050920] | cell surface [GO:0009986]; plasma membrane [GO:0005886] | metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] | PF01431;PF05649; | 3.40.390.10;1.10.1380.10; | Peptidase M13 family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. {ECO:0000269|PubMed:20929849, ECO:0000303|PubMed:20929849}. | Caenorhabditis elegans |
O44952 | LONM_CAEEL | MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLC... | 3.4.21.53 | null | cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrion organization [GO:0007005]; oxidation-dependent protein catabolic process [GO:0070407]; protein catabolic process [GO:0030163]; protein quality control for misfolded or incompletely synthesized pro... | mitochondrial matrix [GO:0005759] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; single-stranded DNA binding [GO:0003697] | PF00004;PF05362;PF02190; | 1.10.8.60;1.20.5.5270;1.20.58.1480;3.30.230.10;2.30.130.40;3.40.50.300; | Peptidase S16 family | null | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120}. | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03120}; | null | null | null | null | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participat... | Caenorhabditis elegans |
O44959 | RIOK1_CAEEL | MEKVEHLNLNIQNILEDVDIDTASSSSDDEPEQAVVKQEKLEAGEQIEEQYDTDSDYDDDIVEFAEATGDFTKKLNAARLNTIGPNAARNRLTVDVERHADTSEDRKRKRVKDRADRATVEQVLDPRTRLVLFRLLQRGTLLNIDGCISTGKEANVYHATGTDNDLAIKIYKTSILTFKDRERYVTGEFRYRHGYCKSNPRKMVAVWAEKEMRNLARMHEVGLPVPKPHLLKGHVLVMDFLGKDGWPAPLLKNANLSQEDAEPMYVGLVRDMRRLYRECKLVHADLSEFNMLVHDGKLWIIDVSQSVEQDHPHALEFLRM... | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305}; | germ cell development [GO:0007281]; germ cell proliferation [GO:0036093]; gonad development [GO:0008406]; maturation of SSU-rRNA [GO:0030490]; meiotic cell cycle [GO:0051321]; negative regulation of MAPK cascade [GO:0043409]; nematode larval development [GO:0002119]; oogenesis [GO:0048477]; phosphorylation [GO:0016310]... | cytosol [GO:0005829]; preribosome, small subunit precursor [GO:0030688] | ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF01163; | 1.10.510.10; | Protein kinase superfamily, RIO-type Ser/Thr kinase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000255|PIRNR:PIRNR038147}; CATALYT... | null | null | null | null | FUNCTION: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). Plays a role in oo... | Caenorhabditis elegans |
O44997 | DAPK_CAEEL | MSDDVNSSATSTSSSTVHFDDTPFEDVYEIETELGSGQFAVVRRVRDRKTGEKYAAKFIKKRRYATSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCAKECLDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRGDSQIKIIDFGLSREIEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVVTYILLSGGSPFLGDNRDETFSNITRVRYHFSDRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWIRGPEGNAIDIRKASCITISHIQSFKTRQRWK... | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P53355}; | innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; regulation of response to stimulus [GO:0048583] | cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] | ATP binding [GO:0005524]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00023;PF12796;PF00531;PF00069; | 1.25.40.20;1.10.533.10;3.40.50.300;1.10.510.10; | Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily | null | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:27661253}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27661253}. Note=Exhibits movement along microtubules. {ECO:0000269|PubMed:27661253}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P53355}; CATALYTI... | null | null | null | null | FUNCTION: Negative regulator of epidermal barrier repair and innate immune responses to wounding (PubMed:19164535, PubMed:27661253). The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule ... | Caenorhabditis elegans |
O45244 | DHX16_CAEEL | MSVEQFINDQLHSIVGISDRSICQYVHALAKKAKSAPDLVEKLRDAGDFPISPAIQSFADQLMSRMPRQATSARQRGPTTAELAEQELNRLNRAVGVLEDYSASSTKTKNVRKRKESSSEDDEAPIKASKPGKSVKPSKSDDSESDIEAMEAKLDADIAERDALAARINKKEKDKTRNVMEKKRDDNKDKEGSSMDKLREESRRQYLKKRKVDKLEELEAIVHDDQTLFAREKLTKREKADMEYRKKVLEYTKAHGKAGDVMKMKRYHLPDASTKQIPSQYVEDDEEDFRPGGDGAKWEEEQLMASMLHLGAKDAKRKEQ... | 3.6.4.13 | null | developmental growth [GO:0048589]; embryonic body morphogenesis [GO:0010172]; feminization of hermaphroditic germ-line [GO:0040022]; germ cell development [GO:0007281]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] | catalytic step 2 spliceosome [GO:0071013] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] | PF00270;PF21010;PF04408;PF00271;PF07717; | 1.20.120.1080;3.40.50.300; | DEAD box helicase family, DEAH subfamily, DDX16/PRP8 sub-subfamily | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; | null | null | null | null | FUNCTION: ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis. {ECO:0000305}. | Caenorhabditis elegans |
O45293 | GALT8_CAEEL | MRRHVVLSIFVFAGIVFAAEEAEKLPKCEHVDPYENLEGWLDLKPLTERKCNHTLKENLTEAESKKSEWGIKSFAFDALSSEKLGPNRNVGKQAHKLCEEEKYDASYSTSVVVIHHNEALSTILRMINGIIEFTPKSLLKEIVLYEDASEEDHVLTKHLEKFAKIKGLEDKLIIKRSEYRQGLIRAKVHASRLATGEVIVFMDSHCEVAERWLEPLLQPIKEDPKSIVLPVVDLINPVSFDYSPSMVAKSGFDWGFTFKWIYLPWEYFETPENNVKPFNSPAMPGGLLAMRKEYFVELGEYDMGMEIWGSENIELSLKAW... | 2.4.1.- | COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; | protein O-linked glycosylation [GO:0006493]; regulation of Notch signaling pathway [GO:0008593] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | metal ion binding [GO:0046872]; Notch binding [GO:0005112]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] | PF00535; | null | Glycosyltransferase 2 family, GalNAc-T subfamily | null | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. | null | null | PATHWAY: Protein modification; protein glycosylation. | null | null | FUNCTION: Potential glycopeptide transferase involved in O-linked oligosaccharide biosynthesis (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity... | Caenorhabditis elegans |
O45307 | OXDD1_CAEEL | MTPKIAIIGEGVIGCSTALQVAQAVPDARVTVLSDRPFEQTCSFGPAGLFRIDDIANREFGKSTFDWFAHLHRTEKGDKTGVKLLSGHIQSDSKERLEQQQKAYGDIVYNFRFLEKREILDLFPNPSEHCIHYTAFASEGNKYVPYLKFQCQARGVEFLHRKVRDLEELANEGYDVIVNCAGLSGGTLAGDDDSVYPIRGVVLDVEAHWHKHFNYKDFITFTIPKENSVVIGSVKQENRWDLEITDVDRKDILERYVALHPAMREPKILGEWSGLRPARKTIRIEKVEKKSEKSGKKYTVVHHYGHGGNGFTLGWGTAVE... | 1.4.3.1 | COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|PubMed:32376478}; | D-amino acid catabolic process [GO:0019478] | cytoplasm [GO:0005737]; peroxisomal matrix [GO:0005782] | D-amino-acid oxidase activity [GO:0003884]; D-aspartate oxidase activity [GO:0008445]; D-glutamate oxidase activity [GO:0047821]; FAD binding [GO:0071949] | PF01266; | 3.30.9.10;3.40.50.720; | DAMOX/DASOX family | null | SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000250|UniProtKB:Q922Z0}. | CATALYTIC ACTIVITY: Reaction=D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate; Xref=Rhea:RHEA:12512, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29990; EC=1.4.3.1; Evidence={ECO:0000269|PubMed:17140416, ECO:0000269|PubMed:20564561, ECO:0000269|PubMed:3... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.02 mM for D-aspartate {ECO:0000269|PubMed:17140416, ECO:0000269|PubMed:20564561}; KM=0.23 mM for D-glutamate {ECO:0000269|PubMed:17140416, ECO:0000269|PubMed:20564561}; KM=0.84 mM for N-methyl D-aspartate {ECO:0000269|PubMed:17140416, ECO:0000269|PubMed:20564561}... | null | null | null | FUNCTION: Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:17140416, PubMed:20564561, PubMed:20603179, PubMed:32376478). May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells (PubMed:22393259). {ECO:0000269|PubMed:171404... | Caenorhabditis elegans |
O45346 | OSM11_CAEEL | MNFITVAALAIVMVLAQANPARVRRNEEMSERYCIKHLDHYNKYCGDNAGPIDRALFGKVAKFCPAYEKHCAVGKAGLVELPDLGSPLVMPPVLPRGSDFASLDLPIADERKPAHIHSSRTAPQTTRLTAAIVATCTPECTAAHCTDECKCAHTHPKVHQMCNPPSSAAMAETCQRWYSKCTMFTPVQY | null | null | cell fate specification [GO:0001708]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of gene expression [GO:0010468]; response to osmotic stress [GO:0006970]; vulval development [GO:0040025] | apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; extracellular space [GO:0005615] | Notch binding [GO:0005112] | null | null | null | null | SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18700817}; Peripheral membrane protein {ECO:0000269|PubMed:18700817}. Note=Concentrated on the apical surface of vulval precursor cells. {ECO:0000269|PubMed:18700817}. | null | null | null | null | null | FUNCTION: Probable secreted lin-12/Notch ligand or co-ligand involved in the mediation of Notch signaling (PubMed:18700817, PubMed:21549604). Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs), acting redundantly with dsl-1 and lag-2 (PubMed:18700817). Required for normal octan... | Caenorhabditis elegans |
O45405 | EXL1_CAEEL | MPTFSLWLPAGSNNVHPCGDPYAHHLFMRCLYHAKHDPTMKFDVKTTNVNKTSQEFKNTGLRRMPGISAEESGETQTFETEDDILDFLEYLKPERGDDEEAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPRLSAKDRAKLVREEPVFSFSV | null | null | chloride transport [GO:0006821] | apical plasma membrane [GO:0016324]; chloride channel complex [GO:0034707]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; muscle cell projection membrane [GO:0036195]; striated muscle dense b... | chloride channel activity [GO:0005254] | null | 1.20.1050.10;3.40.30.10; | Chloride channel CLIC family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14684823}. Membrane {ECO:0000269|PubMed:14684823}. Lysosome membrane {ECO:0000269|PubMed:14684823}. Golgi apparatus membrane {ECO:0000269|PubMed:14684823}. Note=Can be translocated to membranes, possibly as integral membrane proteins, with chloride channel activity (B... | null | null | null | null | null | FUNCTION: Probable chloride channel. {ECO:0000250}. | Caenorhabditis elegans |
O45495 | UB2V1_CAEEL | MVDVPRNFRLLEELEEGQKGKGDGNISWGLEDDSDMTLTRWTASIIGPPRTPYESRIYNLQIQCGGNYPREPPTVRFTTKVHMVGVNQSNGVIDKRNLTTLRNWSNSYMIKTVLEDIRKNMMMAKENLKLQQPAEGAMF | null | null | positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; regulation of locomotion involved in locomotory behavior [GO:0090325]; regulation of protein ... | cytosol [GO:0005829]; dendrite [GO:0030425]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; UBC13-UEV1A complex [GO:0035370] | ubiquitin conjugating enzyme binding [GO:0031624] | PF00179; | 3.10.110.10; | Ubiquitin-conjugating enzyme family | null | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21179194}. Nucleus {ECO:0000269|PubMed:21179194}. Cell projection, dendrite {ECO:0000269|PubMed:21179194}. Perikaryon {ECO:0000269|PubMed:21179194}. | null | null | null | null | null | FUNCTION: Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquitina... | Caenorhabditis elegans |
O45539 | SRC2_CAEEL | MGSCIGKEDPPPGATSPVHTSSTLGRESLPSHPRIPSIGPIAASSSGNTIDKNQNISQSANFVALFQYDARTDDDLSFKKDDILEILNDTQGDWWFARHKATGRTGYIPSNYVAREKSIESQPWYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVRENDSVKHYRIRQLDHGGYFIARRRPFATLHDLIAHYQREADGLCVNLGAPCAKSEAPQTTTFTYDDQWEVDRRSVRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQENLL... | 2.7.10.2 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:G5EE56}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:G5EE56}; | cell differentiation [GO:0030154]; innate immune response [GO:0045087]; nematode pharynx development [GO:0160094]; phosphorylation [GO:0016310]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] | extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; signaling receptor binding [GO:0005102] | PF07714;PF00017;PF00018; | 3.30.505.10;2.30.30.40;1.10.510.10; | Protein kinase superfamily, Tyr protein kinase family, SRC subfamily | PTM: May be phosphorylated on Tyr-500 by csk-1. {ECO:0000269|PubMed:12527374}. | null | CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000269|PubMed:12527374}; | null | null | null | null | FUNCTION: Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development. {ECO:0000269|PubMed:12527374}. | Caenorhabditis elegans |
O45551 | IF4E1_CAEEL | MTETEQTTAPIYPLKRNWTWWYLNDERNKSWEDRLKKVYTFNTVSEFWALYDAIRPPSGLNALCDYNVFRDDIQPMWEVPENSNGGRWLIVIDKGKTPEMVDAIWLEILMALVGEQFGKDMESICGLVCNVRGKGSKISVWTKDCNDDETNMRIGVVLKEKLMAASKDHSKPLFDVIRYEDHESCQKKTSSVVKAKLSLHSSDAPVAEKSAV | null | null | embryo development ending in birth or egg hatching [GO:0009792]; oocyte maturation [GO:0001556]; spermatid development [GO:0007286]; translational initiation [GO:0006413] | cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; P granule [GO:0043186] | RNA 7-methylguanosine cap binding [GO:0000340]; RNA trimethylguanosine cap binding [GO:0000341]; translation initiation factor activity [GO:0003743] | PF01652; | 3.30.760.10; | Eukaryotic initiation factor 4E family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11641215}. Note=When associated with pgl-1. | null | null | null | null | null | FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimeth... | Caenorhabditis elegans |
O45657 | PLX2_CAEEL | MLPESVFLLLISHFLRAVTQPPFETEGVKQKLFHFSGHIDDFIVSRDQQTIYVASLNRLTSLSISNFSIQHEVSLGPVQDSPWCSADGKSCLKDNRPFPTDVRTKILQILPTNQILQCGSVKLGSCSTFNSKLSLITESTIAVAANSPDASTVSKIIDNRLIVAASATKESPYRDPFPAVAIRNLPGLNVENAGDLEGEAAVFLRAAYKNAFKFLYTFTHQHFVFVVAMVTPRESRLPMTTRLIRFCRNDTKFESYSEIELQCRGEDNTNYPFLNAIIQSYDKLIASFSTSSTSPKSSICVFSMQKVKLTFWYNVDRCRS... | null | null | axonal fasciculation [GO:0007413]; embryo development ending in birth or egg hatching [GO:0009792]; motor neuron axon guidance [GO:0008045]; negative regulation of cell adhesion [GO:0007162]; nematode larval development [GO:0002119]; nematode male tail tip morphogenesis [GO:0045138]; positive regulation of axonogenesis... | cell leading edge [GO:0031252]; cell surface [GO:0009986]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116] | semaphorin receptor activity [GO:0017154] | PF08337;PF20170;PF01437;PF01833; | 2.60.40.10;2.130.10.10; | Plexin family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. | null | null | null | null | null | FUNCTION: Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis (PubMed:17507686). In early embryonic development, required for proper ventral closure of the epidermis (PubMed:17507686). During male tail morphogenesis, involved in... | Caenorhabditis elegans |
O45666 | NHR49_CAEEL | MDYFLDASKHIQLNQIDEESSDDFMDLVDPLAEPCAVCGDKSTGTHYGVISCNGCKGFFRRTVLRDQKFTCRFNKRCVIDKNFRCACRYCRFQKCVQVGMKREAIQFERDPVGSPTSGASLNGTPFKKDRSPGYENGNSNGVGSNGMGQENMRTVPQSSSVIDALMEMEARVNQEMCNRYRRSQIFANGSGGSNGNDTDIQQGSDSGASAFAPPNRPCTTEVDLNEISRTTLLLMVEWAKTINPFMDLSMEDKIILLKNYAPQHLILMPAFRSPDTTRVCLFNNTYMTRDNNTDLNGFAAFKTSNITPRVLDEIVWPMRQ... | null | null | cell differentiation [GO:0030154]; determination of adult lifespan [GO:0008340]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of fatty acid metabolic process [GO:0019217]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:00063... | cytoplasm [GO:0005737]; nucleus [GO:0005634] | DNA-binding transcription factor binding [GO:0140297]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] | PF00104;PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. | null | null | null | null | null | FUNCTION: Orphan nuclear receptor (PubMed:25981666). Regulates expression of genes involved in fat metabolism and in maintaining homeostasis of fatty acid saturation, such as lipid desaturase fat-7, and acyl-CoA synthetase acs-2 (PubMed:15719061, PubMed:22511885, PubMed:25981666). May form part of a negative feedback l... | Caenorhabditis elegans |
O45679 | CYSK2_CAEEL | MSRELMVETGGELIGNTPLLKLNKIGKDLGASIAVKVEYMNPACSVKDRIAFNMIDTAEKAGLITPGKTVLIEPTSGNMGIALAYCGKLRGYKVILTMPASMSIERRCLLKAYGAEVILTDPATAVKGAVQRAEELRDVIPNAYILNQFGNPANPEAHYKTTGPEIWRQTQGKVDIVCFGVGSGGTCTGVGRFLKEKNPSVQVFPVEPFESSVINGLPHSPHKIQGMGTGMIPDILDLTLFSEALRVHSDDAIAMAKKLADEESILGGISSGANVCAAVQLAKRPENKGKLIVTTVNSFGERYLSTALYAELRDNAANMK... | 2.5.1.47; 4.4.1.9 | COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:24100226}; | cysteine biosynthetic process from serine [GO:0006535] | cytoplasm [GO:0005737] | cysteine synthase activity [GO:0004124]; L-3-cyanoalanine synthase activity [GO:0050017] | PF00291; | 3.40.50.1100; | Cysteine synthase/cystathionine beta-synthase family | null | null | CATALYTIC ACTIVITY: Reaction=hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide; Xref=Rhea:RHEA:17821, ChEBI:CHEBI:15378, ChEBI:CHEBI:18407, ChEBI:CHEBI:29919, ChEBI:CHEBI:35235, ChEBI:CHEBI:77860; EC=4.4.1.9; Evidence={ECO:0000269|PubMed:24100226}; CATALYTIC ACTIVITY: Reaction=hydrogen sulfide... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.9 mM for O-acetylserine (at 25 degrees Celsius and pH 7.5) {ECO:0000269|PubMed:24100226}; KM=0.4 mM for S-sulfocysteine (at 25 degrees Celsius, pH 8.5 and in absence of dithiothreitol) {ECO:0000269|PubMed:24100226}; KM=1.2 mM for cysteine (at 25 degrees Celsius a... | null | null | null | FUNCTION: Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from eith... | Caenorhabditis elegans |
O45717 | NUD2_CAEEL | MDLSEDQIRGLPHHELLGHFLQMREEFNEFQTSSAEIEKMMDSELDDLKTQLKKAETRVQQMTTEQIRNKDRQDDSRVQFAQVEEQLRRENSHLHEQCESQRERIRKLEQRNDVLETSERNKEYLASDLGSKLDHAIEKIAMLESELYERQVAAEEMHRLREEQLRTTERPRLIVEPLRNDPEILPDEPSPGPSKEEFKMSSEDVFMEDVQHHEDVRMEETIAKIDEVRIDDNKNIQEKSQRVSTGTGAGACINRIVKDLMTKVERLDSILSTIRVSNNSSNNNSSHLTTTRA | null | null | cell migration [GO:0016477]; centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; nuclear migration [GO... | centrosome [GO:0005813]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; nuclear envelope [GO:0005635]; synapse [GO:0045202] | microtubule binding [GO:0008017] | null | 6.10.250.1080; | NudE family | null | SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:20005871}. Note=Recruited to the nuclear envelope by unc-83. {ECO:0000269|PubMed:20005871}. | null | null | null | null | null | FUNCTION: Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). Plays a role in GABAergic synaptic vesicle localization in the ventral... | Caenorhabditis elegans |
O45734 | CPL1_CAEEL | MNRFILLALVAAVVAVNSAKLSRQIESAIEKWDDYKEDFDKEYSESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYRKLNGYRRLFGDSRIKNSSSFLAPFNVQVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIAR... | 3.4.22.15 | null | apoptotic cell clearance [GO:0043277]; immune response [GO:0006955]; lipid droplet disassembly [GO:1905691]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of vitellogenesis [GO:1903188]; proteolysis involved in protein catabolic process [GO:0051603]; regulation of apoptosis involv... | cytoplasm [GO:0005737]; endolysosome [GO:0036019]; extracellular space [GO:0005615]; phagolysosome [GO:0032010]; vesicle lumen [GO:0031983]; yolk granule [GO:0042718] | cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197] | PF08246;PF00112; | 3.90.70.10; | Peptidase C1 family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11707440, ECO:0000269|PubMed:15456850, ECO:0000269|PubMed:16857685}. Cytoplasmic granule {ECO:0000269|PubMed:15456850, ECO:0000269|PubMed:16857685}. Lysosome {ECO:0000269|PubMed:22768338, ECO:0000269|PubMed:24829385}. Endosome {ECO:0000269|PubMed:22768338}. Cytoplasmic... | CATALYTIC ACTIVITY: Reaction=Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.; EC=3.4.22.15; Evidence={ECO:0000250|UniProtKB:P06797}; | null | null | null | null | FUNCTION: Cysteine protease which plays an essential role in the degradation of proteins in lysosomes (PubMed:15456850, PubMed:24829385). During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome-like structure where a slow and controlled degradation of yol... | Caenorhabditis elegans |
O45784 | TAF9_CAEEL | MADTGEKDTETTASGTDGHSKEALAVISMLHECGIQEFDPRVVSMLMDVQYAVTSKILQMSSGLSRHAEKAQIEAEDVQTAADMLGVLTTNAPDREKILQLANDKNQQPLPQIRHNYGLKLPNDRFCQLQQNFVYKADDSYQPMEMQQVTHQPHIIEPPTQVLRPEHVQNMLKRRAPDDDFDS | null | null | embryo development ending in birth or egg hatching [GO:0009792]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitotic cell cycle, embryonic [GO:0009794]; RNA polymerase II preinitiation complex assembly [GO:0051123] | nucleus [GO:0005634]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669] | protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713] | PF02291; | 1.10.20.10; | TAF9 family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11566890}. | null | null | null | null | null | FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similar... | Caenorhabditis elegans |
O45797 | WARTS_CAEEL | MRPAAPGTTPNGASSDIRHQRGVAPIPFGSTNSAIDAHHNSEIRVGRHRAKLDEIRESLKAYEHEAGLLSSHVALGSLATPSSSSVSHSDITNDNAEVMNFSSSSSNAAATTTTVSSAAVSNSNSFRTEGGGHKMRITPMPQRHLMMDTGANETVFRSGKEMIRNGNPSTTISSTPSTTTEESIRIHPAGYRYDMPTPAYHMNNNAPQYSPGYSRPPPPAYDSSPVNTRMTPVATDNYRTHLHMKVHPVVKAPPPNPTMLNHNKNMAPPPPPPAKSTISIETMSEERKADNIQRLYHTSMDKKTASSVVSINVASPHTTK... | 2.7.11.1 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:O95835}; | apical protein localization [GO:0045176]; defecation [GO:0030421]; G1/S transition of mitotic cell cycle [GO:0000082]; hippo signaling [GO:0035329]; negative regulation of protein import into nucleus [GO:0042308]; nematode larval development [GO:0002119]; phosphorylation [GO:0016310]; positive regulation of apoptotic p... | apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator binding [GO:0001223] | PF00069; | 1.10.510.10; | Protein kinase superfamily, AGC Ser/Thr protein kinase family | null | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19605499, ECO:0000269|PubMed:19737560}. Apical cell membrane {ECO:0000269|PubMed:19605499, ECO:0000269|PubMed:19737560}. Note=In epithelial cells, localized near the plasma membrane. In intestinal cells, localized in the subapical membrane region (PubMed:19605499, Pub... | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:O95835}; CATALYTI... | null | null | null | null | FUNCTION: Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization (PubMed:23396260). Plays an essential role in larval development (PubMed:19605499, PubMed:19737560). Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pat... | Caenorhabditis elegans |
O45813 | SNF12_CAEEL | MNGEWKSALRLQIEALAKRNELHRKSSVDEIKKRTVDMDKRIVKLRELVGSSANDAALFYLECVCHADETERLLNRGSSVGKEKKWKKVKRKTSSSVAPPLSRTISSLPGVSSPDVIQTIDVSALEDQTPQRPHWWDQFQLYRRTDLLRFSKQNDRRELWRTQKDFFLSCLGFMVGVGHTMRFPAKVYQHGGGVFFIPYLFSLIFFGLPLVFLHLSLGQYTGQAANTAFQRLMPIGSGVGWALVVIAIPVAVYYNIIVAWAIHYFFQSAKGLLLGDELPWETCRDEWQLDNRCCNLHNLHSCFNSTNSITAPEAFFHSEV... | null | null | amino acid transport [GO:0006865]; positive regulation of antifungal peptide production [GO:0002804]; sodium ion transmembrane transport [GO:0035725] | apical part of cell [GO:0045177]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886] | STAT family protein binding [GO:0097677]; symporter activity [GO:0015293] | PF00209; | null | Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000305|PubMed:21575913}. Vesicle {ECO:0000305|PubMed:21575913}. Note=Localized to vesicles, which may be a type of endosome (PubMed:21575913). Localized to an unknown apical membrane compartment (PubMed:31995031). {... | null | null | null | null | null | FUNCTION: Probably mediates sodium-dependent uptake of unknown small molecule(s) (PubMed:21575913). By positively modulating expression, in the epidermis, of antimicrobial peptides such as nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment (Pu... | Caenorhabditis elegans |
O45818 | DKF2_CAEEL | MDANDYPRLYYTSMPSSSTSMVTTTRFSTSFSPSIPCHRQENFRRHSTSALAKRNGSESEKSAEIRENPDEIEVSRVSGRDSSLAFYTTAHETSSMLSRDSRDETLTPNEHIHQASSRRVSANDSVFEDGYVDFVDEPREHGSRRKSFEKFTDRNGEEKEGRVFELSTPQPTREAAPGAHQFQLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQSGIHKKSIAVEGTEIALRDLRNEALQFIKEIYPEKGCSSLEDYILLYKHDLRSINILQLITTSSDVTDGTLVEVVIGSCPQNERIVVH... | 2.7.11.13 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17728253, ECO:0000269|PubMed:19371715}; | defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; determination of adult lifespan [GO:0008340]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; phospholipase C-activating G protein-coupled receptor signaling pathway [... | cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; serine/threonine protein kinase complex [GO:1902554] | ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] | PF00130;PF00169;PF00069; | 3.30.60.20;2.30.29.30;1.10.510.10; | Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily | PTM: Phosphorylation on Ser-925 by tpa-1 is the dominant regulator of catalysis, phosphorylation on Ser-929 by tpa-1 has a lesser effect. Prolonged phosphorylation results in ubiquitination and degradation. {ECO:0000269|PubMed:17728253}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17728253}. Membrane {ECO:0000269|PubMed:17728253}. Note=Translocation to the cell membrane is required for kinase activation. {ECO:0000269|PubMed:17728253}. | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000269|PubMed:17728253, ECO:00002... | null | null | null | null | FUNCTION: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription facto... | Caenorhabditis elegans |
O45824 | CL38_CAEEL | MAIFYDDPLERLNQPIKTKSYRKKQVVQRVHVFIFDNWKLILLGILNLIFLIIAIVFAILFFVGSADCAQLPDYTTSPASQLTTSAISSRTSEVQTNAITTTQGTPSNKTSTTTPSTSKVICASGFTLVGTKCGKLVSSNQPRTEADSICKGYGGSTLFSVRNEQETRDMLDFVKDSNIDFLWTGLVCNQTARTSCIWDVKSGTTADYNNFADGFPNVVYGYCIYFIVTGNSAGQWGSEQCSQLMNFVCELPTTIRDPDCKYNYNKNCYIRFDITLTIPQAQRFCNEKGADLVSIHSANENRFILTIYDIHGQILLGGLA... | null | null | dorsal/ventral axon guidance [GO:0033563]; motor neuron axon guidance [GO:0008045]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of gene expression [GO:0010629]; negative regulation of sensory neuron axon guid... | membrane [GO:0016020] | carbohydrate binding [GO:0030246] | PF00059; | 3.10.100.10; | null | null | SUBCELLULAR LOCATION: Membrane {ECO:0000303|PubMed:18434533}; Single-pass type II membrane protein {ECO:0000255}. | null | null | null | null | null | FUNCTION: Involved in negative modulation of unc-40-mediated axon outgrowth (PubMed:18434533). Required for proper presynaptic development in axons that have reached their targets (PubMed:18434533). May function in concert with E3 ubiquitin-protein ligase rpm-1 in regulating axon outgrowth (PubMed:18434533). {ECO:00002... | Caenorhabditis elegans |
O45876 | APH1_CAEEL | MGYLLTIACYIASFSPSIALFCSFIAHDPVRIILFFLGSFFWLVSLLFSSLAWLGLSTVLPDTFLLSLTVCIIAQELSRVAYFMLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFAIFSGPGTIGLPNALKTGEIDTNRAGKYLPLCYTLSAILLTLFHVTWTIMVWDSCHKIGRIPSAFVPGAAAVVSHLLVTFLSSLNSRGFHVLVFAVQFLILLICIAYCNVIMGGTISSFVNGIGQSITDAVTLKQVRTLIEERKLRTQRQSVPDEPMTERAGTSNTVNA | null | null | cell fate commitment [GO:0045165]; cell fate commitment involved in pattern specification [GO:0060581]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic morphogenesis [GO:0048598]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; oocyte development [GO:0048599]; ph... | endoplasmic reticulum [GO:0005783]; gamma-secretase complex [GO:0070765] | protein-macromolecule adaptor activity [GO:0030674] | PF06105; | null | APH-1 family | null | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. | null | null | null | null | null | FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for... | Caenorhabditis elegans |
O45923 | TTM1_CAEEL | MTISMISPSSIRLSSDKRDSSSSNLPANIEEDTQSVSSSDSGVSADSIDHHHHGHGHGHSHGGHGHSHTHNNDDSSSDCSGAGGGAHKHSHDEKYQKGRRAEKVLWAVAALSAVFIAAEFVGGFWAQSLAIMTDAGHMLSDLLSFIISIFAIRCARLPASKRLSFGYERAEVLGALTSVIILWVLTTVLVVVAIQRIVNNEHEVDADVMLITAGVGVLFNIVMGLVLHFGTGGHGHTHGGHSSHGHAHDGKNVNVRAALIHVIGDLVQSIGVLIAALIIRFTGWTLADPICTFLFSIIVLFTTVTVMRDIFFVLMEATPS... | null | null | response to cadmium ion [GO:0046686]; response to nematicide [GO:0093002]; response to zinc ion [GO:0010043]; zinc ion transmembrane transport [GO:0071577] | apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] | zinc ion transmembrane transporter activity [GO:0005385] | PF01545; | 1.20.1510.10; | Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily | null | SUBCELLULAR LOCATION: [Isoform a]: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:23717214}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform b]: Apical cell membrane {ECO:0000269|PubMed:23717214}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:23... | null | null | null | null | null | FUNCTION: Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc (PubMed:23717214). Involved in cadmium resistance, possibly by promoting its transport from cells (PubMed:15256590). Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of... | Caenorhabditis elegans |
O45935 | KLP19_CAEEL | MSSDASLRVVVRARPMNGRETKEGASRCVQFYENTKQIVINESATFTFDAVFADTSDQESVYETTALPLLDRIFAGFNATVLAYGQTGSGKTYTMGTEDNVGTDEMRRGIIPRLVSALFQRIMNTEAPESFAVTVSMFEVYGDNVYDLLRPDKVKLNVHGDEKNCTVVNLTAVPVIDLKGALKQLAVGCHYRTKAETAMNAMSSRSHAVFTVFVEKTATAECDSAFSAKLQLVDLAGSERLKKTEAEGNRMKEGININGGLLILSQVIAALATKQKHIPYRNSVITRVLQDSLGGNSFTVFLACISPADSNSQETLNTLR... | null | null | cell division [GO:0051301]; meiotic chromosome condensation [GO:0010032]; meiotic spindle midzone assembly [GO:0051257]; microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] | chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; spindle [GO:0005819] | ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] | PF00225; | 3.40.850.10; | TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family | null | SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:15452142}. Nucleus {ECO:0000269|PubMed:15452142}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15452142}. Chromosome {ECO:0000269|PubMed:15452142}. Note=Localizes to nuclei of the distal mitotic zone (PubMed:15452142). During mitotic prophase in emb... | null | null | null | null | null | FUNCTION: Required for chromosome movement and orientation on spindle poles in mitosis and meiosis (PubMed:15452142). May play a role in early anterior-posterior chromosome movement in mitotic embryos (PubMed:15452142). {ECO:0000269|PubMed:15452142}. | Caenorhabditis elegans |
O45947 | GLT10_CAEEL | MVAICIKIGERERKRVHIMLLAYTWKTRVSSHQCNKSPIFGLFAIQFSNICSNLLLLQQKLSMGLSRYLSRRHHWVIQYCGLLLFLYLIYSYVATSNDGPNLHEDIPVFQGQGKDRANPNPPAALGDEALDPFEKYRGHEKIKWEDEAAYEKEKRREGPGEWGKPVKLPEDKEVEKEALSLYKANGYNAYISDMISLNRSIKDIRHKECKNMMYSAKLPTVSVIFPFHEEHNSTLLRSVYSVINRSPPELLKEIILVDDFSEKPALRQPLEDFLKKNKIDHIVKVLRTKKREGLIRGRQLGAQDATGEILIFLDAHSEAN... | 2.4.1.41 | COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; | protein O-linked glycosylation [GO:0006493] | Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139] | carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] | PF00535;PF00652; | 2.80.10.50; | Glycosyltransferase 2 family, GalNAc-T subfamily | null | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23956, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12788, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:53604, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2... | null | PATHWAY: Protein modification; protein glycosylation. | null | null | FUNCTION: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250}. | Caenorhabditis elegans |
O45952 | CSC1_CAEEL | MPPRKIKKDPAVVAMADTLETRVKDLLEEYKKKLREVALQTAKAESDRIIATIKPKYRDMPIMEFLASPPDDFYIESGEEEEEGEAAVAVKQELPSEPDMEIDDAAAAQKTSIPIGQNSGRNTVQVKQEPEIDDDAAHETSIPIAPSGQNSGRNTAADEHRRNEIITPAGQVLPLPTLQPEKPFRAPHVDEEIAFSVNGSPLVLAGRTTATAAGKENRKKSKKSGAASKKAAAAAGPLQPETENAGTSV | null | null | meiotic chromosome segregation [GO:0045132]; mitotic cell cycle [GO:0000278]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic cleavage furrow ingression [GO:1990386]; mitotic cytokinesis [GO:0000281]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle midzone assembly [GO:005125... | chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; meiotic spindle midzone [GO:1990385]; microtubule cytoskeleton [GO:0015630]; mitotic spindle midzone [GO:1990023] | null | null | null | Borealin family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12707312}. Chromosome, centromere {ECO:0000269|PubMed:12707312}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12707312}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the central spindle from ana... | null | null | null | null | null | FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis during mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. In the complex, it may be required to direc... | Caenorhabditis elegans |
O45962 | RLE1_CAEEL | MAPTGQGGQWQEVLCCSICNRHFNETFLPVSLICGHVICRKCAEKPENQTKPCPHDDWKTTHSPSEYPNNVALLSVIFPRKQCMTLSGAVSEAEKRVDQLSIQIAKFFREADSERGGTVSSREISRTLQRKVLALLCYQWREVDGRLKTLKMCRGISERVMIEIILSIQSNTHVSSQLWSAVRARGCQFLGPAMQDDVLRLILMTLETGECIARKNLVMYVVQTLASDYPQVSKTCVGHVVQLLYRASCFNVLKRDGESSLMQLKEEFRTYESLRREHDSQIVQIAFESGLRIGPDQWSALLYADQSHRSHMQSIIDKLQ... | 2.3.2.27 | null | determination of adult lifespan [GO:0008340]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; response to heat [GO:0009408]; ubiquitin-dependent protein catabo... | cytoplasmic stress granule [GO:0010494] | double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842] | PF18386;PF21206; | 1.20.120.1790;3.30.40.10; | null | null | null | CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000303|PubMed:17276341, ECO:0000303|PubMed:24448648}; | null | PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. {ECO:0000269|PubMed:17276341}. | null | null | FUNCTION: E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance (PubMed:17276341). Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic... | Caenorhabditis elegans |
O46036 | CTBP_DROME | MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKDAPNLICTPHAAFFS... | null | null | chaeta development [GO:0022416]; chromatin remodeling [GO:0006338]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling... | ISWI-type complex [GO:0031010]; nucleus [GO:0005634] | DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; tr... | PF00389;PF02826; | 3.40.50.720; | D-isomer specific 2-hydroxyacid dehydrogenase family | null | SUBCELLULAR LOCATION: Nucleus. | null | null | null | null | null | FUNCTION: Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. {ECO:0000269|PubMed:9524128, ECO:0000269|PubMed:9525852}. | Drosophila melanogaster (Fruit fly) |
O46043 | PARG_DROME | MSKSPDGGISEIETEEEPENLANSLDDSWRGVSMEAIHRNRQPFELENLPPVTAGNLHRVMYQLPIRETPPRPYKSPGKWDSEHVRLPCAPESKYPRENPDGSTTIDFRWEMIERALLQPIKTCEELQAAIISYNTTYRDQWHFRALHQLLDEELDESETRVFFEDLLPRIIRLALRLPDLIQSPVPLLKHHKNASLSLSQQQISCLLANAFLCTFPRRNTLKRKSEYSTFPDINFNRLYQSTGPAVLEKLKCIMHYFRRVCPTERDASNVPTGVVTFVRRSGLPEHLIDWSQSAAPLGDVPLHVDAEGTIEDEGIGLLQ... | 3.2.1.143 | null | ATP generation from poly-ADP-D-ribose [GO:1990966]; Cajal body organization [GO:0030576]; carbohydrate metabolic process [GO:0005975]; DNA damage response [GO:0006974]; female germ-line stem cell population maintenance [GO:0036099]; heterochromatin formation [GO:0031507]; maintenance of protein location in nucleus [GO:... | cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] | ADP-ribosylserine hydrolase activity [GO:0140292]; poly(ADP-ribose) glycohydrolase activity [GO:0004649] | PF05028;PF20811; | null | Poly(ADP-ribose) glycohydrolase family | null | null | CATALYTIC ACTIVITY: Reaction=[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose; Xref=Rhea:RHEA:52216, Rhea:RHEA-COMP:16922, Rhea:RHEA-COMP:16923, ChEBI:CHEBI:15377, ChEBI:CHEBI:57967, ChEBI:CHEBI:142512; EC=3.2.1.143; Evidence={ECO:0000250|UniProtKB:Q867X0}; | null | null | null | null | FUNCTION: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells. {ECO:0000269|PubMed:14676324}. | Drosophila melanogaster (Fruit fly) |
O46084 | PGAM5_DROME | MRKLTSFVCGTGAGLAAYYLQRLRDPQTVVQNSWTHSDKPVDPWALWDTNWDCREPRALVRPLRNSQPEEENRYNAELEKAKAKKARHIILVRHGEYLDVGDSDDTHHLTERGRKQAEFTGKRLCELGIKWDKVVASTMVRAQETSDIILKQIDFEKEKVVNCAFLREGAPIPPQPPVGHWKPEASQFLRDGSRIEAGFRRYFHRAYPDQEKESYTLIVGHGNVIRYFVCRALQFPAEGWLRININHASITWLTISPSGNVSIKYLGDSGFMPAELLTNRIPRDVKNVV | 3.1.3.16 | null | peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of mitochondrial fission [GO:0090141]; protein dephosphorylation [GO:0006470]; regulation of mitochondrion organization [GO:0010821]; response to anesthetic [GO:0072347]; response to heat [GO:0009408] | membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] | kinase binding [GO:0019900]; myosin phosphatase activity [GO:0017018]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine phosphatase activity [GO:0004722] | PF00300; | 3.40.50.1240; | Phosphoglycerate mutase family, BPG-dependent PGAM subfamily | null | SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. | CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:19590015}; CATALYTIC ACTIVITY: Reaction=H... | null | null | null | null | FUNCTION: Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity. {ECO:0000269|PubMed:19590015}. | Drosophila melanogaster (Fruit fly) |
O46102 | PAPD1_DROME | MNSLVRRSAQQLSLWRTYCIKHNASEAASPGRNAGRPNYEEFIGRHQRQAQCSIVVQVSSEKSYEELYNYCSSFGSIMGAHHYCVRQDETLHYILLEYATSDEAAAAIGAGVTNGELSGVPVRSPFLWFRAAGGGRRSPKLVANTAPALLSLDGTRQVDQRHLLGLLRGAADIEEQVQQLYEHTRLNELGIRMRFLAALQVQQAIAGMFPAAQAQPFGSSVNGFGRMGCDLDLILRFDSDMGAKIPLEAAVPSRLVYHTKENLSNGRSQTQRHMECFGDMLHLFLPGVCHVRRILQARVPIIKYHHEHLDLEVDLSMSNL... | 2.7.7.19 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:Q9NVV4}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q9NVV4}; | mitochondrial mRNA 3'-end processing [GO:0090616]; mitochondrial mRNA polyadenylation [GO:0097222]; mRNA polyadenylation [GO:0006378]; tRNA stabilization [GO:0036416] | mitochondrion [GO:0005739] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] | PF03828; | 1.10.1410.10;3.30.460.10; | DNA polymerase type-B-like family | null | SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:27176048}. | CATALYTIC ACTIVITY: Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, ChEBI:CHEBI:173115; EC=2.7.7.19; Evidence={ECO:0000250|UniProtKB:Q9NVV4}; | null | null | null | null | FUNCTION: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. This is not required for transcript stability or translation but may maintain mRNA integrity by protecting 3' termini from degradation. {ECO:0000269|PubMed:27176048}. | Drosophila melanogaster (Fruit fly) |
O46106 | NOI_DROME | METLLEQQRRLHEERERLVKLMVDEHATKKPGEKERIHSEHRLKYLMELHHNSTSQLRDLYEDKDNERKAEIAALSGPNEFNEFYARLKQIKQFYKSHPAEVSVPLSVEFDEMIRVYNNPDDMSALVEFTDEEGGGRYLDLNECYELYLNLRSVEKLDYITYLMSFDHVFDIPRERKNREYRIYIETLNDYLHHFILRIQPLLDLEGELLKVELDFQRQWLMGTFPGFSIKETESALANTGAHLDLSAFSSWEELASLGLDRLKSALVALGLKCGGTLEERAQRLFSTKGKSTLDPALMAKKPSAKTASAQSREHERHKE... | null | null | fertilization [GO:0009566]; mitotic cell cycle [GO:0000278]; mRNA splicing, via spliceosome [GO:0000398] | catalytic step 2 spliceosome [GO:0071013]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686] | RNA binding [GO:0003723]; zinc ion binding [GO:0008270] | PF13297;PF16837;PF12108;PF11931; | null | SF3A3 family | null | SUBCELLULAR LOCATION: Nucleus. Note=Excluded from the nucleoli. | null | null | null | null | null | FUNCTION: Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility. {ECO:0000250}. | Drosophila melanogaster (Fruit fly) |
O46166 | TXI1_ERAAG | MKLQLMICLVLLPCFFCEPDEICRARMTHKEFNYKSNVCNGCGDQVAACEAECFRNDVYTACHEAQKG | null | null | null | extracellular region [GO:0005576] | toxin activity [GO:0090729] | null | 1.10.2010.20; | Helical arthropod-neuropeptide-derived (HAND) family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9589602}. | null | null | null | null | null | FUNCTION: Toxin that paralyzes insects. May have a direct effect on the insect central nervous system. {ECO:0000269|PubMed:9589602}. | Eratigena agrestis (Hobo spider) (Tegenaria agrestis) |
O46339 | HTH_DROME | MAQPRYDDGLHGYGMDSGAAAAAMYDPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASR... | null | null | animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; compound eye development [GO:0048749]; compound eye photoreceptor fate commitment [GO:0001752]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; haltere morphogenesis [GO:0048735]; head morphogenesis [GO:0060323]; imagin... | cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667] | cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; p... | PF05920;PF16493; | 1.10.10.60; | TALE/MEIS homeobox family | null | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:9346235, ECO:0000269|PubMed:9450936, ECO:0000269|PubMed:9463350}. | null | null | null | null | null | FUNCTION: All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; requir... | Drosophila melanogaster (Fruit fly) |
O46373 | ADT1_RABIT | MSDQALSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAAQREFSGLGNCLTKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQTVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWKKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV | null | null | adaptive thermogenesis [GO:1990845]; ADP transport [GO:0015866]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation ... | membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial permeability transition pore complex [GO:0005757] | ATP:ADP antiporter activity [GO:0005471]; oxidative phosphorylation uncoupler activity [GO:0017077] | PF00153; | 1.50.40.10; | Mitochondrial carrier (TC 2.A.29) family | PTM: Under cell death induction, transglutaminated by TGM2. Transglutamination leads to formation of covalent cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming polymers. {ECO:0000250|UniProtKB:P48962}. | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P02722}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:P12235}; Multi-pass membrane protein {ECO:0000255}. Note=The complex formed with ARL2BP, ARL2 and SLC25A4/ANT1 is expressed in mitochondria (By similarity). May l... | CATALYTIC ACTIVITY: Reaction=ADP(in) + ATP(out) = ADP(out) + ATP(in); Xref=Rhea:RHEA:34999, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P48962}; CATALYTIC ACTIVITY: Reaction=H(+)(in) = H(+)(out); Xref=Rhea:RHEA:34979, ChEBI:CHEBI:15378; Evidence={ECO:0000250|UniProtKB:P48962}; | null | null | null | null | FUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-... | Oryctolagus cuniculus (Rabbit) |
O46374 | TOP2A_PIG | MEVSPLQPVNENMQVNKTKKNEEAKKRLSIERIYQKKTQLEHILLRPDTYIGSVESVTQQMWVYDEDIGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFHPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDLYLKDKVDETGNPLKIIHEQVNHRWEVCLTMSEKGFQQISFVNSIATS... | 5.6.2.2 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ion... | apoptotic chromosome condensation [GO:0030263]; DNA topological change [GO:0006265]; negative regulation of DNA duplex unwinding [GO:1905463]; regulation of circadian rhythm [GO:0042752]; resolution of meiotic recombination intermediates [GO:0000712]; rhythmic process [GO:0048511]; sister chromatid segregation [GO:0000... | cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] | ATP binding [GO:0005524]; DNA binding, bending [GO:0008301]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; magnesium ion binding [GO:0000287] | PF00204;PF00521;PF08070;PF02518;PF01751;PF16898; | 3.30.1360.40;3.30.1490.30;3.30.230.10;3.40.50.670;3.30.565.10;3.90.199.10;1.10.268.10; | Type II topoisomerase family | PTM: Phosphorylation has no effect on catalytic activity (By similarity). However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation (By similarity). {ECO:0000250|UniProtKB:P11388}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P11388}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P11388}. Nucleus {ECO:0000250|UniProtKB:P11388}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P11388}. | CATALYTIC ACTIVITY: Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; | null | null | null | null | FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in regulating the period length of ... | Sus scrofa (Pig) |
O46382 | BIG1_BOVIN | MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHIPQEHEGDLDPQTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNDILYDGENHD... | null | null | endomembrane system organization [GO:0010256]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; positive regulation of wound healing [GO:0090303]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; r... | cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; small nuclear ribonucleoprotein complex [GO:0030532]; trans-Golgi network [GO:0005802] | guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase A regulatory subunit binding [GO:0034237] | PF20252;PF16213;PF01369;PF09324;PF12783; | 1.10.220.20;1.10.1000.11; | null | PTM: Phosphorylated. In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1 (By similarity). {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Membrane {ECO:0000250}. Note=Translocates from cytoplasm t... | null | null | null | null | null | FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-... | Bos taurus (Bovine) |
O46385 | SVIL_BOVIN | MKRKERIARRLEGIETDTQPILLQSCTGLVTHRLLEEDTPRYMRATDPASPHIGRSNEEEETSDSSLEKQTRSKQCTETSGIHADSPYSSGIMDTQSLESKAERIARYKAERRRQLAEKYGLTLDPEADSETPSRYSRSRKDPEAAEKRGVRSERSAESSRDAGSSYSRTELSGLRTCVAESKDYGLHRSDGVSDTEVLLNAENQRRGQEPSATGLARDLPLAGEVSSSFSFSGRDSALGEVPRSPKAVHSLPSPSPGQPASPSHSTSDLPLPAEARASIGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVREESAR... | null | null | actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; positive regulation of cytokinesis [GO:0032467] | actin cytoskeleton [GO:0015629]; anchoring junction [GO:0070161]; cell projection [GO:0042995]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; podosome [GO:0002102] | actin filament binding [GO:0051015]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546] | PF00626;PF02209; | 3.40.20.10;1.10.950.10; | Villin/gelsolin family | null | SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium {ECO:0000250|UniProtKB:O95425}. Cell projection, podosome {ECO:0000250|UniProtKB:O95425}. Midbody {ECO:0000269|PubMed:20309963}. Cleavage furrow {ECO:0000269|PubMed:20309963}. Note=... | null | null | null | null | null | FUNCTION: [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation t... | Bos taurus (Bovine) |
O46392 | CO1A2_CANLF | MLSFVDTRTLLLLAVTSCLATCQSLQEATARKGPTGDRGPRGERGPPGPPGRDGDDGIPGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGASGAPGPQGFQGPAGEPGEPGQTGPAGARGPPGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGPVGNPGPAGPAGPRGEVGLPGVSGPVGPPGNPGANGLTGAKGAAGLPGVAGA... | null | null | extracellular matrix organization [GO:0030198] | collagen type I trimer [GO:0005584]; collagen type IV trimer [GO:0005587]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] | extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872] | PF01410;PF01391; | 2.60.120.1000; | Fibrillar collagen family | PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}. | null | null | null | null | null | FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen). | Canis lupus familiaris (Dog) (Canis familiaris) |
O46409 | APOA4_PIG | MFLKAVVLSLALVAVTGARAEVNADQVATVMWDYFSQLGSNAKKAVEHLQKSELTQQLNTLFQDKLGEVNTYTEDLQKKLVPFATELHERLTKDSEKLKEEIRRELEELRARLLPHATEVSQKIGDNVRELQQRLGPFTGGLRTQVNTQVQQLQRQLKPYAERMESVLRQNIRNLEASVAPYADEFKAKIDQNVEELKGSLTPYAEELKAKIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKQAEELKAKISANADELRQKLVPVAENVHGHLKGNTEGLQKSLLELRSHLDQQVEEFRLKVEPYGETFNKALVQ... | null | null | acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipoprotein metabolic process [GO:0042157]; phosphatidylcholine metabolic process [GO:0046470]; phospholipid efflux [GO:0033700]; positive regulation of fatty acid bi... | blood microparticle [GO:0072562]; chylomicron [GO:0042627]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; very-low-density lipoprotein particle [GO:0034361] | cholesterol transfer activity [GO:0120020]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543] | PF01442; | 1.20.120.20; | Apolipoprotein A1/A4/E family | null | SUBCELLULAR LOCATION: Secreted. | null | null | null | null | null | FUNCTION: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. | Sus scrofa (Pig) |
O46411 | 5NTC_BOVIN | MTTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGP... | 2.7.1.77; 3.1.3.5; 3.1.3.99 | COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:8031149}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250|UniProtKB:P49902}; | adenosine metabolic process [GO:0046085]; allantoin metabolic process [GO:0000255]; dGMP metabolic process [GO:0046054]; GMP metabolic process [GO:0046037]; IMP catabolic process [GO:0006204]; IMP metabolic process [GO:0046040]; negative regulation of defense response to virus by host [GO:0050689]; protein K48-linked u... | cytosol [GO:0005829] | 5'-nucleotidase activity [GO:0008253]; ATP binding [GO:0005524]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleoside phosphotransferase activity [GO:0050146]; ubiquitin protein ligase activity [GO:006163... | PF05761; | 3.40.50.1000; | 5'(3')-deoxyribonucleotidase family | null | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8031149, ECO:0000269|PubMed:9371705}. | CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence={ECO:0000269|PubMed:8031149, ECO:0000269|PubMed:9371705}; PhysiologicalDirection=left-to-right; Xref=Rhe... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.09 mM for IMP (in absence of allosteric activator) {ECO:0000269|PubMed:8031149}; KM=0.09 mM for IMP (in the presence of 4.5 mM ATP) {ECO:0000269|PubMed:8031149}; Vmax=12.5 umol/min/mg enzyme for the hydrolysis of IMP (in the presence of 4.5 mM ATP) {ECO:0000269|P... | null | null | null | FUNCTION: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:8031149, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucl... | Bos taurus (Bovine) |
O46419 | LIPT_BOVIN | MLIPFSMKNCFQLLCNLKVPAAGFKNTVKSGLILQSISNDVYHNLAVEDWIHDHMNLEGKPVLFLWRNSPTVVIGRHQNPWQECNLNLMREEGVKLARRRSGGGTVYHDMGNINLTFFTTKKKYDRMENLKLVVRALKAVHPHLDVQATKRFDLLLDGQFKISGTASKIGRNAAYHHCTLLCGTDGTFLSSLLKSPYQGIRSNATASTPALVKNLMEKDPTLTCEVVINAVATEYATSHQIDNHIHLINPTDETVFPGINSKAIELQTWEWIYGKTPKFSVDTSFTVLHEQSHVEIKVFIDVKNGRIEVCNIEAPDHWLP... | 2.3.1.-; 2.3.1.200 | null | protein modification process [GO:0036211] | cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739] | lipoate-protein ligase activity [GO:0016979]; lipoyltransferase activity [GO:0017118] | null | 3.30.390.50; | LplA family | null | SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:8206978}. | CATALYTIC ACTIVITY: Reaction=L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]; Xref=Rhea:RHEA:16413, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10500, Rhea:RHEA-COMP:10501, Rhea... | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=13 uM for (R)-lipoyl-5'-AMP {ECO:0000269|PubMed:8206978}; Vmax=135 nmol/min/mg enzyme for the reaction with (R)-lipoyl-5'-AMP as lipoyl donor {ECO:0000269|PubMed:8206978}; | PATHWAY: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.9. {ECO:0000269|PubMed:8206978}; | null | FUNCTION: Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2 (By similarity). In vitro, it is also ... | Bos taurus (Bovine) |
O46420 | CP51A_PIG | MVLLGLLQAGGSVLGQAMEQVTGVNLLSSLLLACAFTLILVYLFRQAIGHLAPLPAGAKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFRQHVSIIEKETKEYFQSWGESGERNLFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRQSEEKIDDILQTLLDSTYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTS... | 1.14.14.154 | COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:Q16850}; | bile acid biosynthetic process [GO:0006699]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; sterol metabolic process [GO:0016125] | endoplasmic reticulum membrane [GO:0005789] | heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; steroid 7-alpha-hydroxylase activity [GO:0008387]; sterol 14-demethylase activity [GO:0008398] | PF00067; | 1.10.630.10; | Cytochrome P450 family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}. | CATALYTIC ACTIVITY: Reaction=a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:54028, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,... | null | PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. {ECO:0000250|UniProtKB:Q64654}. | null | null | FUNCTION: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal o... | Sus scrofa (Pig) |
O46421 | EST1_MACFA | MWLRALVLATLAAFTAWGHPSSPPVVDTVHGKVLGKFVSLEGFTQPVAVFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCSQDAVAGQVLSELFTNRKENTPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLVVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQLAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTAVLVKKGDVKPLAEQIAIAAGCQTTTSAVMVHCLRQKTEEELLETTLKMKFFSLDLHGDPRESHPFLG... | 3.1.1.1; 3.1.1.13 | null | cholesterol metabolic process [GO:0008203]; lipid catabolic process [GO:0016042]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; regulation of bile acid biosynthetic process [GO:0070857];... | cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811] | carboxylesterase activity [GO:0106435]; sterol esterase activity [GO:0004771] | PF00135; | 3.40.50.1820; | Type-B carboxylesterase/lipase family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P23141}. Cytoplasm {ECO:0000250|UniProtKB:P23141}. Lipid droplet {ECO:0000250|UniProtKB:P23141}. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the drop... | CATALYTIC ACTIVITY: Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039}; CATALYTIC ACTIVITY: Reaction=cholesteryl (9Z-octade... | null | null | null | null | FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid... | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
O46427 | CATH_PIG | MWAVLSLLCAGAWLLGPPACGASNLAVSSFEKLHFKSWMVQHQKKYSLEEYHHRLQVFVSNWRKINAHNAGNHTFKLGLNQFSDMSFDEIRHKYLWSEPQNCSATKGNYLRGTGPYPPSMDWRKKGNFVSPVKNQGSCGSCWTFSTTGALESAVAIATGKMLSLAEQQLVDCAQNFNNHGCQGGLPSQAFEYIRYNKGIMGEDTYPYKGQDDHCKFQPDKAIAFVKDVANITMNDEEAMVEAVALYNPVSFAFEVTNDFLMYRKGIYSSTSCHKTPDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLIERGKN... | 3.4.22.16 | null | bradykinin catabolic process [GO:0010815]; dichotomous subdivision of terminal units involved in lung branching [GO:0060448]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; immune response-regulating signaling pathway [GO:0002764]; membrane protein proteolysis [GO:0033619]; metanephros development [G... | alveolar lamellar body [GO:0097208]; cytosol [GO:0005829]; extracellular space [GO:0005615]; lysosome [GO:0005764] | aminopeptidase activity [GO:0004177]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; HLA-A specific activating MHC class I receptor activity ... | PF08246;PF00112; | 3.90.70.10; | Peptidase C1 family | null | SUBCELLULAR LOCATION: Lysosome. | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.; EC=3.4.22.16; | null | null | null | null | FUNCTION: Important for the overall degradation of proteins in lysosomes. | Sus scrofa (Pig) |
O46432 | MA2B1_FELCA | MGADARPLGVRAGGGGRGAARPGTSSRALPPPLPPLSFLLLLLAAPGARAAGYETCPMVHPDMLNVHLVAHTHDDVGWLKTVDQYFYGIHNDVQHAGVQYILDSVISSLLVEPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIIDQMTLGLRFLEDTFGKDGRPRVAWHIDPFGHSREQASLFAQMGFDGLFFGRLDYQDKRVREENLGLEQVWRASASLKPPAADLFTSVLPNIYNPPEKLCWDTLCADKPFVEDRRSPEYNAEELVNYFLQLATAQGQHFRTNHTIMTMGSD... | 3.2.1.24 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; | mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491] | Golgi membrane [GO:0000139]; lysosome [GO:0005764] | alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] | PF09261;PF07748;PF01074;PF21260; | 2.60.40.1360;3.20.110.10;1.20.1270.50;2.60.40.1180; | Glycosyl hydrolase 38 family | PTM: Processed into 3 peptides of 72 kDa, 41 kDa and 12 kDa. | SUBCELLULAR LOCATION: Lysosome. | CATALYTIC ACTIVITY: Reaction=Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.; EC=3.2.1.24; | null | null | null | null | FUNCTION: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. {ECO:0000250}. | Felis catus (Cat) (Felis silvestris catus) |
O46480 | NDEL1_RABIT | MDGEDIPDFSSLKEETAYWKELSLKYKQTFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENSFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVMNSNGTKFSRSGHTSFFDKGAVNGF... | null | null | cell differentiation [GO:0030154]; cell migration [GO:0016477]; centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; lysosome localization [GO:0032418]; microtubule nucleation [GO:0007... | centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; spindle [GO:0005819] | microtubule binding [GO:0008017] | PF04880; | 6.10.250.1080; | NudE family | PTM: Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE (By similarity). {ECO:0000250}.; PTM: Palmitoylation at Cys-273 reduces affinity for dynein. {ECO:0000250}. | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the interphase centrosome and the mitotic spindle. Localizes... | null | null | null | null | null | FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule m... | Oryctolagus cuniculus (Rabbit) |
O46491 | CP7A1_PIG | MMSISLLGGIVTAVCCCLWLLLGMRRRQTGEPPLENGIIPYLGCALQFGANPLEFLRANQRKHGHIFTCQLMGNYVHFITNPLSYHKVLCHGKYLDWKKFHFTASAKAFGHRSIDPSDGNTTDNINKTIIKTLQGDALNLLAAAMMENLQLVLRPQVAPQPEKPAWVTEGMYSFCYRVMFEAGYVTLFGKDPIGHDAQKALILNNLDNFKQFDKIFPALVAGFPIHVFKTGHYAREKLAEGLRLQKLRKRDHISELVRFLNDTLSTLDDAEKAKSLLAVLWASQANTIPATFWCLFQTIRSPEAMKAASEEVNKTLEKAG... | 1.14.14.23; 1.14.14.26 | COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:P22680}; | bile acid biosynthetic process [GO:0006699]; cellular response to cholesterol [GO:0071397]; cellular response to glucose stimulus [GO:0071333]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; regulation of bile acid biosynthetic process [GO:0070857] | endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] | 24-hydroxycholesterol 7alpha-hydroxylase activity [GO:0033782]; cholesterol 7-alpha-monooxygenase activity [GO:0008123]; heme binding [GO:0020037]; iron ion binding [GO:0005506] | PF00067; | 1.10.630.10; | Cytochrome P450 family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein {ECO:0000250|UniProtKB:P22680}. Microsome membrane {ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein {ECO:0000250|UniProtKB:P22680}. | CATALYTIC ACTIVITY: Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21812, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:C... | null | PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000250|UniProtKB:P22680}.; PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000250|UniProtKB:P22680}. | null | null | FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrom... | Sus scrofa (Pig) |
O46512 | CP19A_HORSE | MILEMLNPMHYNLTSMVPEVMPVATLPILLLTGFLFFVWNHEETSSIPGPGYCMGIGPLISHLRFLWMGLGSACNYYNKMYGEFVRVWISGEETLVISKSSSTFHIMKHDHYSSRFGSTFGLQYMGMHENGVIFNNNPAVWKALRPFFVKALSGPSLARMVTVCVESVNNHLDRLDEVTNALGHVNVLTLMRRTMLDASNTLFLRIPLDEKNIVLKIQGYFDAWQALLIKPNIFFKISWLSRKHQKSIKELRDAVGILAEEKRHRIFTAEKLEDHVDFATDLILAEKRGELTKENVNQCILEMMIAAPDTLSVTVFFMLC... | 1.14.14.14 | COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:P11511}; | female gonad development [GO:0008585]; lipid metabolic process [GO:0006629]; response to estradiol [GO:0032355] | endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] | aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506] | PF00067; | 1.10.630.10; | Cytochrome P450 family | null | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P11511}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250|UniProtKB:P11511}; Multi-pass membrane protein {ECO:0000305}. | CATALYTIC ACTIVITY: Reaction=3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38191, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15... | null | PATHWAY: Steroid hormone biosynthesis. {ECO:0000250|UniProtKB:P11511}. | null | null | FUNCTION: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy ... | Equus caballus (Horse) |
O46522 | CY24B_BOVIN | MGNWVVNEGISIFVILVWLGMNVFLFVWYYRVYDIPDKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVNNSDPYSIALSDIGDKPNETYLNFVRQRIKNPEGGLYVAVTRLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAQRIVRGQTAESLLKHQPRNCYQNISQWGKIENCPIPEFSGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKME... | 1.-.-.- | COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305}; | defense response [GO:0006952]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; monoatomic ion transmembrane transport [GO:0034220]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801] | lysosome [GO:0005764]; membrane raft [GO:0045121]; monoatomic ion channel complex [GO:0034702]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] | metal ion binding [GO:0046872]; superoxide-generating NAD(P)H oxidase activity [GO:0016175] | PF08022;PF01794;PF08030; | 3.40.50.80;2.40.30.10; | null | PTM: Phosphorylated on Ser and Thr residues. {ECO:0000250}.; PTM: Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation. {ECO:0000250|UniProtKB:Q61093}. | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04839}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04839}. Note=As unassembled monomer may localize to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P04839}. | null | null | null | null | null | FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel ... | Bos taurus (Bovine) |
O46540 | ANF_SHEEP | MGSSAITTSFLLFVAFQLPGQTGANPVYGSVSNADLMDFKNLLDRLEDKMPLEDEAVPSQVLSEQNEEAGAPLSPLSEVPPWDGGRSTQPREMGAPSDGDPGNPPRSVLLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR | null | null | cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; female pregnancy [GO:0007565]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:00082... | cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; perikaryon [GO:0043204] | hormone activity [GO:0005179]; hormone receptor binding [GO:0051427] | PF00212; | null | Natriuretic peptide family | PTM: The precursor molecule is proteolytically cleaved by CORIN at Arg-122 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing ... | SUBCELLULAR LOCATION: [Long-acting natriuretic peptide]: Secreted {ECO:0000250|UniProtKB:P01160}. Note=Detected in blood. {ECO:0000250|UniProtKB:P01160}.; SUBCELLULAR LOCATION: [Vessel dilator]: Secreted {ECO:0000250|UniProtKB:P01160}. Note=Detected in blood. {ECO:0000250|UniProtKB:P01160}.; SUBCELLULAR LOCATION: [Kali... | null | null | null | null | null | FUNCTION: [Atrial natriuretic peptide]: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG... | Ovis aries (Sheep) |
O46550 | CAV2_CANLF | MGLETEKADVQLCMDDDAYSRHSAVDFGDLEQLADSGSDRDPRRLNSHLQVGFEDVIAEPVSTHSFDKVWICSHALFEVSKYVIYKFLTLLLAMPMAFAAGVLFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDAVIAPLCSSVGRSFSSVSLQVSHD | null | null | caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; endoplasmic reticulum organization [GO:0007029]; insulin receptor signaling pathway [GO:0008286]; mitochondrion organization [GO:0007005]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of dopamine receptor signal... | caveola [GO:0005901]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane raft [GO:0044853]; sarcolemma [GO:0042383] | D1 dopamine receptor binding [GO:0031748]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901] | PF01146; | null | Caveolin family | PTM: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylat... | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000269|PubMed:9472032}; Peripheral membrane protein {ECO:0000269|PubMed:9472032}. Cell membrane {ECO:0000269|PubMed:9472032}; Peripheral membrane protein {ECO:0000269|PubMed:9472032}. Membrane, caveola {ECO:0000269|PubM... | null | null | null | null | null | FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role... | Canis lupus familiaris (Dog) (Canis familiaris) |
O46559 | LIPC_RABIT | MGSPLCVPIFLAVCILIQSSTHGQSLRPEPFGRRARVTATKKTLLETETRFLLFKDKANKGCQIRLHHADTLQECGFNSSLPLVMIVHGWSVDGLLESWIWQMVAALKSQPARPVNVGLVDWISLAHSHYAVAVRNARLVGQEVAALLQWLEESAPFSRSNVHLIGYSLGAHVAGFAGSYISGKHKIGRITGLDAAGPLFEGTSASDRLSPDDATFVDAIHTFTREHMGLSVGIKQPVGHYDFYPNGGSFQPGCHFLELYKHIAQHGLNALSQTIKCAHERSVHLFIDSLLHPSMQSTAYQCSDMDSFSQGLCLGCTKGR... | 3.1.1.3; 3.1.1.32; 3.1.1.5 | null | fatty acid biosynthetic process [GO:0006633]; triglyceride catabolic process [GO:0019433] | high-density lipoprotein particle [GO:0034364] | 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; apolipoprotein binding [GO:0034185]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylserine 1-acylhydrolase activity [GO:0... | PF00151;PF01477; | 3.40.50.1820;2.60.60.20; | AB hydrolase superfamily, Lipase family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11150}. | CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000269|PubMed:1770315}; CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosph... | null | null | null | null | FUNCTION: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein pa... | Oryctolagus cuniculus (Rabbit) |
O46560 | PDXK_PIG | MQAGSWVVGGGDSDSRVLSIQSHVVRGYVGNRAATFPLQVLGFEVDAVNSVQFSNHTGYAHWKGQVLNSDELHALYEGLKLNNVNQYDYVLTGYTRDKSFLAMVVDIVRELKQQNPRLVYVCDPVMGDKWDGEGSMYVPEDLLPVYREKVVPVADIITPNQFEAELLTGRRIHSEEEALAVMDMLHAMGPDTVVITSSDLPSPRGKDYLIALGSQRTRSPDGSVATQRIRMEICKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSAMHHVLRRTIQCAKAKAGEGLKPSPAQLELRMVQSKRDIEDPEVVVQAT... | 2.7.1.35 | COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:9924807}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:9924807}; Note=Divalent metal cations. Zn(2+) is more efficient than Mg(2+). {ECO:0000269|PubMed:9924807}; | phosphorylation [GO:0016310]; pyridoxal 5'-phosphate salvage [GO:0009443] | cytosol [GO:0005829] | ATP binding [GO:0005524]; metal ion binding [GO:0046872]; pyridoxal kinase activity [GO:0008478] | PF08543; | 3.40.1190.20; | Pyridoxine kinase family | PTM: The N-terminus is blocked. | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O00764}. | CATALYTIC ACTIVITY: Reaction=ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:10224, ChEBI:CHEBI:15378, ChEBI:CHEBI:17310, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216, ChEBI:CHEBI:597326; EC=2.7.1.35; Evidence={ECO:0000269|PubMed:9924807}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10225; Evide... | null | PATHWAY: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. {ECO:0000250|UniProtKB:O00764}.; PATHWAY: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1. {ECO:0000250|UniProtKB:O00764}.; PATHWAY: Cofactor metabolism; ... | null | null | FUNCTION: Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:9924807). PLP is the active form of vitamin B6, and ac... | Sus scrofa (Pig) |
O46561 | PRLR_SHEEP | MKENAASRVLFILLLFLFASLLNGQSPPEKPKLIKCRSPGKETFTCWWEPGADGGLPTNYTLTYRKEGETLIHECPDYKTGGPNSCYFSKKYTSIWKMYVITVSAINQMGISSSDPLYVDVTYIVEPEPPVNLTLELKHPEDRKPYLWIKWSPPTLTDVKSGWFSIQYEIRLKPEKATDWETHFAPKLTQLKIFNLYPGQKYLVQIRCKPDHGYWSEWSPESFIQIPNDFPVKDTSMWIFVGVLSAVICLIMVWAVALKGYSMVTCILPPVPGPKIKGFDIHLLEKGKSEELLRALESQDFLPTSDCEDLLMEFIEVDDS... | null | null | positive regulation of cell population proliferation [GO:0008284] | external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] | cytokine binding [GO:0019955]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046]; prolactin receptor activity [GO:0004925] | PF09067; | 2.60.40.10; | Type I cytokine receptor family, Type 1 subfamily | null | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. | null | null | null | null | null | FUNCTION: This is a receptor for the anterior pituitary hormone prolactin. | Ovis aries (Sheep) |
O46564 | BMP2_RABIT | MVAGTRCLLALLLPQVLLGGAAGLIPELGRRKFAASSGRPSPQPSDDILSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGAPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLTSIPPEEFITSAELQVFREQMQEALGDDSGFHHRINIYEIIKPATANSKFPATRLLDTRLVNQNTSRWESFDVTPAVMRWTAQGHANHGFVVEVTHLEEKQGVSKRHVRISRSLHPDEHSWSQIRPLLVTFGHDGKGHPLHRREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYH... | null | null | BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiocyte differentiation [GO:0035051]; cartilage development [GO:0051216]; epithelial to mesenchymal transition [GO:0001837]; heart development [GO:0007507]; heart induction [GO:0003129]; lung vasculature development [GO:00... | cell surface [GO:0009986]; extracellular space [GO:0005615] | BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; phosphatase activator activity [GO:0019211] | PF00019;PF00688; | 2.60.120.970;2.10.90.10; | TGF-beta family | null | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P12643}. | null | null | null | null | null | FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMP... | Oryctolagus cuniculus (Rabbit) |
O46567 | GCR_SAISC | MDSKESLTPGKEENPSSVLTQERGNVMDFCKILRGGATLKVSVSSTSLAAASQSDSKQQRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLQLLEESIANLNRSTSVPENPKSSASSSVSAAPKEKEFPKTHSDVSSEQQNLKGQTGTNGGNVKLYTADQSTFDILQDLEFSSGSPGKETNQSPWKSDLLIDENCLLSPLAGEEDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSSSNVTLPQVKTEKEDFIELCTPGVIKQEKLSTVYCQASFPGANIIGNKMSAIS... | null | null | cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944] | centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spindle [GO:0005819] | DNA-binding transcription factor activity [GO:0003700]; estrogen response element binding [GO:0034056]; nuclear glucocorticoid receptor activity [GO:0004883]; nuclear receptor activity [GO:0004879]; steroid binding [GO:0005496]; steroid hormone binding [GO:1990239]; zinc ion binding [GO:0008270] | PF02155;PF00104;PF00105; | 3.30.50.10;1.10.565.10; | Nuclear hormone receptor family, NR3 subfamily | PTM: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity. {ECO:0000250}.; PTM: Increased proteasome-mediated degradation in response to glucocorticoids. {ECO:0000250|UniProtKB:P04150}.; PTM: Phosphorylated in the absence of hormone; becomes hyperphosphorylated i... | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15857751}. Nucleus {ECO:0000269|PubMed:15857751}. Mitochondrion {ECO:0000250|UniProtKB:P04150}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P04150}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P04150}. Note=Aft... | null | null | null | null | null | FUNCTION: Receptor for glucocorticoids (GC) (PubMed:10775802, PubMed:11703081). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:10775802, PubMed:11703081, PubMed:1... | Saimiri sciureus (Common squirrel monkey) |
O46576 | BMP4_RABIT | MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRHPQPSKSAVIPDYMRDLYRLQSGEEEEEEQMPSGGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEAISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEAVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNHGLAVEVTHFHHTRTHQGQHVRLSRSLLQGSGDWAQFRPLLVTFGHDGRGHALTRRRRAKRSLKHHPQRARKKNKNCRRHALYVDFSD... | null | null | blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; BMP signaling pathway [GO:0030509]; chondrocyte differentiation [GO:0002062]; deltoid tuberosity development [GO:0035993]; endochondral ossification [GO:0001958]; glomerular capillary formation [GO:0072104]; heart induction [GO... | extracellular space [GO:0005615] | BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083] | PF00019;PF00688; | 2.60.120.970;2.10.90.10; | TGF-beta family | null | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. | null | null | null | null | null | FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit ... | Oryctolagus cuniculus (Rabbit) |
O46598 | HAVR1_CHLAE | MADPIMHLQVVILSLILHLADSVADSVNVDGVAGLSITLPCRYNGAITSMCWNRGTCSVFSCPDGIVWTNGTHVTYRKETRYKLLGNLSRRDVSLTIANTAVSDSGIYCCRVKHSGWFNDMKITISLKIGPPRVTIPIVRTVRTSTTVPTTTTTTLPTTTTLPTTTTLPTTMTLPTTTTLPMTTTLPTTTTVPMTTTLPTTLPTTTTLPTTLPTTTTLPTTLPTTTTLPTTMTLPMTTTLPTTTTLPTTTTLPTTTTLPTTTTLPTTTLPTMTLPTTTTLPTTMTLPMTTTLPTTTTLPTTTTLPTTTMVSTFVPPTPLP... | null | null | phagocytosis, engulfment [GO:0006911]; positive regulation of mast cell activation [GO:0033005] | cell surface [GO:0009986]; motile cilium [GO:0031514]; plasma membrane [GO:0005886] | phosphatidylserine binding [GO:0001786]; virus receptor activity [GO:0001618] | PF07686; | 2.60.40.10; | Immunoglobulin superfamily, TIM family | null | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D42}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96D42}. | null | null | null | null | null | FUNCTION: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Con... | Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) |
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