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Q60367
MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRANIYALKKLGVERILAINSVGSLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMTDPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKEIAIYKNWGDVVGMTGYPEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKCICKDALKHAVIG
Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Catalytic Activity: phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate Sequence Mass (Da): 28664 Sequence Length: 252 Pathway: Purine metabolism; purine nucleoside salvage. EC: 2.4.2.44
O27633
MIGIIGGTGIYEMAEYGRLERRGSLITPYGKTPEISVFKLHGRRVAFIPRHSPGHDKPPHMVNYRANIWALKELGVRQIIATNAVGSLKRSIGPGDFVVPHDFLDFTRSRPSTFYDEKTVHVDMTEPYCRNIRSALSGSSGVVDGGVYVCTEGPRFETPAEIRMFQTLGGTVVGMTGLPEAVLARELEMCYASICLVSNYAASISPSKLTIDEVFEIMDEKKNDLIDIIDAAIRDLKTEQSCPCQHALRGADVNNHEEELYEGFNDICKPEKEEQHHDGP
Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Catalytic Activity: phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate Sequence Mass (Da): 31100 Sequence Length: 280 Pathway: Purine metabolism; purine nucleoside salvage. EC: 2.4.2.44
Q9HZK1
MSVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHPHRFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLAG
Function: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Involved in quorum sensing. Catalytic Activity: phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate Sequence Mass (Da): 26266 Sequence Length: 245 Pathway: Purine metabolism; purine nucleoside salvage. EC: 2.4.2.44
B1WQH2
MNTIYPVIWSNNKVLLIDQTSLPSRYTLVEISRYEDMAKAIKTMIVRGAPAIGVAAAYGMYLGARDIQTQDRETFLKHLDKIAQILRQTRPTAVNLFWAISRMLKTAYETLGTVEEIKKILLETAQKIQEEDLQTCQAIGHNSLSILPTNPEKLTILTHCNAGALATAGYGTALGVIRSVWTAGRLNRVFADETRPRLQGAKLTAWECVQEKIPVTVISDNMAAHCMQKGLIDMVVVGADRIAANGDTANKIGTYGLAVIAKMHQVPFYVAAPLSTVDFSLETGDLIPIEERDPSELYQIGNTVIYPDGVDYYNPAFDVTPADLITGIITEQKTVNPKELITLKG
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 37939 Sequence Length: 345 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. EC: 5.3.1.23
P0CN40
MVAAAPSNKERLPDMMTSIRLDQSGRVEIIDQLLLPHSVVWMPVSTPEEAFDAIKTMRIRGAPAIASLAALTLRSYLSSSSSPVSSSSSSSDVISWVGQTIDYLQSSRPTAVNLGEAMDRIRAALKDSEAQNQTAGDIIQRVKKICGDVHDEDLERNMKMGRLGAEWLWKKRGGGKKGLKVMTVCNTGSLATSGYGTAIGVITALFQEDHLDTAYYAQTTPYHQGSRLTSLELTTLQIPACMICDTMLGSLFQHEDIDGVIVGADRVVKNGDTANKIGTYQAAVLAQRHNVPFMVVAPVTTIDLSLPTGAEIHIEHRPAAEATQVRGLDTETGKLSVVRITPEGVGEGDKPWQRVYNPSFDVTPAELISAVVTEKGVAERKEGEKSIDVASIC
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 42378 Sequence Length: 393 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. Subcellular Location: Cytoplasm EC: 5.3.1.23
A9JRE2
MTLEAIRYRSGSLQILNQLLLPRETVYDEIRSVRDGYEAIKSMKVRGAPAIAIVGCLSLAVELRAGAGAEDLVSFVRDSLCHLTSARPTAVNMGRAARELMEFTENESMEKNTEQLRDSVIGWIEEMLERDVNDNKKIGNYGAQHILSGVPRDSVTILTHCNTGSLATAGYGTALGVVRSLHMLGRLKRLYCTETRPYNQGARLTAYEAVAEGFPATLITDSMAALAMREKSITAVVVGADRVVANGDTANKVGTYQLAIAAKHHGIPFYVAAPSTSCDLSLESGRDIVIEERPAEELTSINGVPVAAPGIDVWNPAFDVTPHQLITGGIITELGVFLPSELQAALTGRLTAL
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 37980 Sequence Length: 353 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. Subcellular Location: Cytoplasm EC: 5.3.1.23
Q47AR7
MNIDGIPTRTLRAHPDRRAIDIIDQTRLPHALHWVRVATLEEAAHAIRAMQVRGAPLIGATAAYGLAIALDFEASDRRLAEAVALLGATRPTAVNLHWALARMENILRPLAPEARCDAAWAEAAAIAEEDVAQNAAIGQHGLKLWNDLIVADGQTLNIMTHCNAGWLATVDWGTALSPVYAAHDAGVPVHVWVSETRPRNQGLLTAWELEQHGVPHTLIADNAAGLLMRNGKVDAVIVGADRIAANGDVANKVGTYLKALACADNGIPFYVAAPRSTLDFACPEGASIPIEERDGDEFRLVHGLDSRGVPSALRQLPAGEDVANPAFDVTPNWLVKAIITERGVCPASRDGLLALYPEEARG
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 38703 Sequence Length: 362 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. EC: 5.3.1.23
B8J4S7
MDDHIRFDHQTFELHLLDQRLLPAQEADFVCRSVEDVVYALQTMVVRGAPAIGVTAAWGCVLALREAQGPDWAARLEQGMERIAAARPTAVNLRWAVERMRGVWLAAGGEAGDPAPLLTAFAHAAQTMQDEDVAVCKTLGRHGAACIEDGDCVLTHCNAGALATAGYGTALGVIRAAVEAGKKVSVIADETRPFLQGARLTAWELERDGIPVTVACDNACALLMSRGLVQRVVVGADRIAANGDTANKIGTYGVALLARHFHIPFYVAAPLSTIDPATPDGAGIPIEERPELEVTHMGETRLCPENVPVLNFAFDVTPAEYISGIITEKGVLYPPYGLSIWAALNDLSTGRSAGISAGPLRDEDDAPDAEPDWSRERS
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 40338 Sequence Length: 378 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. EC: 5.3.1.23
A8ZYA5
MTATDPAPTRPIWLADDKKRVQIIDQRMLPHNLVIVDLTTVDQVIEAIGEMMVRGAPLIGVTGAFGVFIAVQNALERGDFEAQVRKECLRIKEARPTAVNLAWGVDRVCAAVFSKTLPADCLAAALAEASAIAEEEVDNCRRIGVHGVGLIETISRQKGGKTVNVLTHCNAGWLACVEHGTATAPIYKAFEKRIDIHVWVDETRPLNQGARLTAWELGQRGVAHTVITDNAGGHLMQHGMVDMVIVGTDRSTYTGDVANKVGTYLKALAARDNNIPFYVALPSSTFDWEMTDGLAQIPIEERNPDEVRCVEGLCPDGRVEKVRIVPENSRAANYAFDVTPARLVTGFITERGVCGAGRDQVLALFPEKR
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 40202 Sequence Length: 369 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. EC: 5.3.1.23
Q4ZQ92
MRDRLLAAEKVKAIDWRDDALYLLDQRVLPFEEVWHRYTTAEGVAEAIRTMVVRGAPAIGISAAYGAVLAARARIAQGADWYPALEEDMQLLADSRPTAVNLFWALNRMRDRLMRVKDGDDPLAALEAEAVAIHLSDREANLTMAQLGADLIRKHQGNLQTVLTHCNTGALATGGFGTALGVIRAAHLEGMIERVYADETRPWLQGSRLTAWELANEGIPVTLNADSAAAHLMRTKGITWVIVGADRITANGDVANKIGTYQLAVAAMHHGVRFMVVAPSSTIDMEMASGDDIVIEERDGRELLEVGGQRVGAEVEAFNPVFDVTPADLIDAIVTEKGIVERPDTARMAQLMSRKHLH
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 39087 Sequence Length: 358 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. EC: 5.3.1.23
Q9UZ16
MEVRYKPEELTKLPRSVEYKERTVYMINQRLLPREFKVEAFRTVESVAEAIKNMTVRGAPAIGAAAAFGLALYAETSKAKSKDEFMDGFYKAYETLKNTRPTAVNLFWALNRIKKLVEEHLEDPLDEIKSLIVNEAQKIADEDVEANLRMGHYGAEVLPEGNLLTHCNAGSLATVHLGTVGAVVRVMHKDGSLKLLWLDETRPVLQGARLSAWEYSYDGLNVKLIADNAAAFVMQQGLVDAIIVGADRIVANGDFANKIGTYMLAVLAREHGIPFFAVAPLSSIDMSLKSGKEIPIEERSPEEVLTCGGCRIAPDVPVYNPAFDVTPHKYVTGIITDKRVVWPPFKRNLKKLFGEQ
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 39549 Sequence Length: 356 EC: 5.3.1.23
Q7UF90
MNEAETIRYHAAHNGRPAELDLLDQTKLPGTLTRLVCTTIDQTHDAIQRLVVRGAPAIGIAAAYGVTLTPVDAESNSSLPEAQARYRQTIDYLATSRPTAVNLFWALDRMRAIVDDFSGPVAELRERLVTEAIRIHDDDRQMCRSIGCHGATLLADCKSVMTHCNAGSLATSMWGTALAPMYHLHESGHSLEVFADETRPLLQGARLTAWELHQAGIPVTVCTDSMSGSLMRQGRVDAVIVGADRIAANGDVANKIGTYPLAVLAKYHNIPFYVAAPTNTFDSELESGDLIPIEQRSADEVSYPCGTDSPRQTPEGVAVVNPAFDVTPAELVTALITEKGVISEPDTAKVRAHLGL
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Catalytic Activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate Sequence Mass (Da): 38390 Sequence Length: 356 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. EC: 5.3.1.23
A4W7Z4
MTDNLQLTHLVDACRWIGAKGWAPATGGNMSIRQNDAFCWLSESGKDKGSLTIDDFLQVDIASNRAPSGRKPSAETGLHTLIYRLFPEANAVLHVHTVNATVLSRLVKETELRISGFEMQKSLTGQSTHLDTVTIPVFDNDQDIDALASRIAHYAQERPFNYGFLLRGHGLTCWGRDVAEARRHLEGLEFLFECEMRLRQLEKI
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Catalytic Activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O Sequence Mass (Da): 22910 Sequence Length: 204 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. EC: 4.2.1.109
A9H8G1
MISTDPWAGAVQDIIAAGRRMDRFGWVPATAGNISRRLPDGRIAITRSGGHKGHLTADGVIEVTADGRAVRAGDRPSAETLLHCHVYEASPDVGAVLHGHSVASTVLSMMEQGDAILLSGYEVLKVFEGQQTHDTTVRLPVFDNDQDIARLSGVVAPYLGRMPAGYVIRGHGVYVWGGTMDVALARLEGLEFLLACELERRKVAR
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Catalytic Activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O Sequence Mass (Da): 22053 Sequence Length: 205 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. EC: 4.2.1.109
Q0BPT9
MTGTVTSVRQPPEWAAVTIVAAGQRMDARGWVPATAGNISVRLPDDTIAITSSGNHKGFLKTSDIMVVDQAGKPLTPGLKPSAETLLHCQIYRLDNQAGAVVHGHSVAATVLSMAPGKNDAPPDFIRLEGYEVLKAFGVKTHQITLDLPILDNDQDMERLASIAEPILLRGAPLGYLIRGHGVYVWGGDMAAALARLEGLEFLLACELERRRLR
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Catalytic Activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O Sequence Mass (Da): 23025 Sequence Length: 214 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. EC: 4.2.1.109
Q2SKZ2
MFDLHKFSLRAQEIIEAGGFLYGAGWSPATSSNYSARIDDANIAITVSGKHKGRLQAQDIMVVDLQGRAVASQMKSSAETLLHTVIYDLKPNVGAVLHTHSVTATVLSRALRPNTEIVFEDYELQKAFRGVYTHEGRCVVPIFDNTQDIEALSALSVEYLKEHSDCPGYLIRGHGMYTWGETMAECLRHVEAMEFLLACELEMMRIKS
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Catalytic Activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O Sequence Mass (Da): 23183 Sequence Length: 208 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. EC: 4.2.1.109
Q96GX9
MSGCDAREGDCCSRRCGAQDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLVVPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKVGLDPSQLPVGENGIV
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Catalytic Activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O Sequence Mass (Da): 27125 Sequence Length: 242 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. Subcellular Location: Cytoplasm EC: 4.2.1.109
C4R7D9
MSSCFCSKSQETEKRGAVSEDQLVISDDSTHPANLICELCKVFYNNGWVTGTGGGISIREGSKIYIAPSGVQKERMVPDNMFVMDLESENYLRTPLTLKPSACTPLFLSAYKMRDAGACIHTHSQAAVMVTLLYDKVFEISSIEQIKAIPKVTEKGNLMYSDRLVIPIIENTEREEDLTDSLQQAIEEYPGTTAVLVRRHGIYVWGETVWKAKVYNEAIDYLLELALKMHQLGIPTVKQN
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Catalytic Activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O Sequence Mass (Da): 26874 Sequence Length: 240 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. Subcellular Location: Cytoplasm EC: 4.2.1.109
Q4WDE1
MKAYWYDNKPGDQREPHDSGRPVTVDYLASIGVQYYHFPSLESVNELAKERGYKNRDEIVVSPQAMGDVYEEKVKMFFNEHLHEDEEIRYIRDGEGYFDVRGQEDEWVRIKLAKDDLIILPAGIYHRFTTDDKNYVKAMRLFQEEPKWTPLNRGPDVDENSHRQSYLRTIQNKTVA
Cofactor: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate. Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Catalytic Activity: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) Sequence Mass (Da): 20848 Sequence Length: 176 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. Subcellular Location: Cytoplasm
O31669
MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLSEKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHHTDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRIFVTTEGWVPIYEKDSVNQ
Cofactor: Binds 1 Fe(2+) cation per monomer. Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Catalytic Activity: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) Sequence Mass (Da): 20824 Sequence Length: 178 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.
Q3ZBL1
MVEAWYMDEAADDPRLPHRAEPARPVGLEQLRRLGVLYWKLDADKYENDPELEKIRKERNYSWVDIITISKDKLPNYEEKIKMFFEEHLHLDEEIRYILDGSGYFDVRDQEDRWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGDPVWTPYNRPSDHLEARTQYLEFLAQSA
Cofactor: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate. Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Catalytic Activity: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) Location Topology: Peripheral membrane protein Sequence Mass (Da): 21487 Sequence Length: 179 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. Subcellular Location: Cytoplasm
C3ZAH2
MVRAWYMDDSDADQRAPHMTDPPQPVELDQLKNIGVLYWQLSGNEDDETLAGIRKDRGYSYNDLIEITPEKLPNYEQKIKTFFEEHLHLDEEIRYCVGGSGYFDVRDKGDKWIRIEMEKGDLIVLPAGIYHRFTLDEKNYIKAMRLFVGEPVWTPYNRPADDKDARKEYLKTMGLAA
Cofactor: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate. Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Catalytic Activity: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) Sequence Mass (Da): 20723 Sequence Length: 177 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. Subcellular Location: Cytoplasm
A5EES7
MTQLIVYEAGNPSHVLLQTSDFDVIAGKVAALGARIERWEARHPIAPGASNEEVLSAYGHEIDRLKRERGYTNGDVVRIKPGNPNWPELRGKFLQEHVHVEDEVRFFVEGTGAFYLHLDDKVYQLVGEAGDLLSVPHGVKHWFDGGPEADFTCIRLFTNQEGWVAHFTGDAISDAFPKYEIAA
Cofactor: Binds 1 Fe(2+) cation per monomer. Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Catalytic Activity: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) Sequence Mass (Da): 20442 Sequence Length: 183 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.
Q59WJ5
MVEFYFHDNKDTLENFTEDHNSGEPVSFDQLAEIGVIYKYITTQEELDALATEREYKNRDVVTLNLPAFNNDIDAYNAKMQQFYKEHYHEDEEIRYIAEGEGYFDVRDKQDRWIRAKLSPYDLLILPAGIYHRFTLTNAAKHVKAVRLFKDEPKWEAINRDTGKNTEARELYAKTIAV
Cofactor: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate. Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Catalytic Activity: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) Sequence Mass (Da): 21008 Sequence Length: 178 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. Subcellular Location: Cytoplasm
F6W3G8
MVRAWRILQEETDDPRDALYSDESVSLEQLAQVGVEYFKFDADTFEQNDDYLKLKNNRGYSYSDTISVSRATLPDFDAKIKSFFEEHLHTDDEIRFILDGSGYFDVRDLDGRQLRDCWIRIECVKGDLLVLPSGIYHRFTLDKKDYIKALRLFIGVPVWTPHNRPADSMKERLDYVSKYLTATT
Cofactor: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate. Function: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Catalytic Activity: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) Sequence Mass (Da): 21565 Sequence Length: 184 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. Subcellular Location: Cytoplasm
O32028
MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVILLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDVTAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVEEVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVHSTELVLKVIKRIH
Function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively . Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine (By similarity). Catalytic Activity: H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine Sequence Mass (Da): 25265 Sequence Length: 231 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. EC: 3.2.2.9
Q1LTN6
MIIGVIGAMEQEVMLLSKQLAKLNIWQQARCNIYSGWLHGKKVVLVQSGIGKVSAALGCTLLLTNFEATLVINIGSAGGLSPALAVGDIIVSEEVQYHDVNVTAFGYDKGQMAQYPLLFPASPSLVALTKQLTEHTNINVVCGQIISGDIFINGGQELYKLKRRFPQAIAVDMEVTAIAQICYLFAVPFVGIRVITDIADSVSHKSFKDNLITVVSHLSLLVSDIIQAL
Function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Catalytic Activity: H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine Sequence Mass (Da): 24698 Sequence Length: 229 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. EC: 3.2.2.9
P57306
MKIGIIGAINQETERLKKIIHFYIEKKINTYKIYIGKFKSHDVFLIKSGIGKVSASVATMILIDLYKPDTIINSGSAGSLQSFLKIGDIIIPKKTCYYDVDLTNFGYTRGQIPGYPKEFTVNEKICNFFKKNADKYQLKYIKGLILSGDTFVRENESIKILKKQFPSAIAVEMESSAIAQVCYKFNIPLIIIKSISDESDNNATVNFKENIDFVSYQLSKFVKIILENLIDM
Function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Catalytic Activity: H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine Sequence Mass (Da): 26344 Sequence Length: 232 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. EC: 3.2.2.9
Q89AQ7
MKKEIKKNYRIGIIAALQQEVQILFNKLKNYKINKISNITFYIGNIHNIHVVLAKSGVGKVFSGITCALLLQKYKVKFIINIGSAGSLNKNLKPGSIIIPTNVCYHDVNLTAFGYSIGQIKNCPKTFLSNTLMLKLTEKYLFENKIKYQKKLMISGDIFIDTCEKKSLLKKRFPKAIAVDMEAAAIAHVCYQFNIPILIIKSISDSSDINAADNFKYFINLASKNSSLVTINVLQTLFKNTKNILFDNNNRC
Function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Catalytic Activity: H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine Sequence Mass (Da): 28426 Sequence Length: 252 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. EC: 3.2.2.9
Q6AQW7
MKVGIIAAMEEELTLLVDRLDNCEEVQLGHCKYYTGQINGVEVGLMRCGIGKVNAAIGTTLMIDKLKPKCLINTGVAGGFINEMNVGDIVISSSVRHHDADATAFGYELGQIPDMPSEFQADRRLVEMATKVNLKSKARIFEGPVFSGDSFIHTTEQVENILKNFPQIMAVEMEGASIAQTSHLFNIPFVLIRSISDKVRETKSADTYTQSMEESAKNSVQVVFEMVEQLKEGM
Function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Catalytic Activity: H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine Sequence Mass (Da): 25783 Sequence Length: 234 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. EC: 3.2.2.9
Q819E7
MSIQVFCDFDGTITNNDNIMSIMEKFAPPEAEEVKNKILSQELSIQEGVSQLFQLIPTNLHDDIIQFLIETAEIRSGFHEFIQFVKENNISFYVISGGMDFFVYPLLQGIIPKEQIYCNETDFSAEFITVKWPHSCDDHCQIHCGLCKSSLIRKLSDTDDFHIVIGDSITDLQAAKQADKVFARDFLITKCEENHIAYTPFETFQDVQAELKLLLEVKA
Function: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalytic Activity: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate Sequence Mass (Da): 25042 Sequence Length: 219 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. EC: 3.1.3.87
O31667
MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSKTLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGMDFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSEPNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVKEVQEWLQNKNAGESSLK
Function: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalytic Activity: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate Sequence Mass (Da): 27002 Sequence Length: 235 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. EC: 3.1.3.87
C0ZL41
MSKKLVLFCDFDGTITEKDNIVAIVRKFAPPEWEALTEQILSQKISVQEGVGKLFQLLPSSLRQDIIDFIVHEATIRPGFAEFVSYCREEGIELLITSGGIDFFLEPILAPFDLADVPIYCNGSDFSGERITITWPNACDEHCTNGCGMCKTTIIRRYDPATHFRIVIGDSITDLAGAKIADYVIARSFLADKAEELQLPHSTFATFHDVIRILQQVQQEVV
Function: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalytic Activity: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate Sequence Mass (Da): 24846 Sequence Length: 222 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. EC: 3.1.3.87
C4KZ51
MSTHVICDFDGTITEEDNIIALMRRFAPPEWVELKDSVLNQTLSIREGVGQMFSLLPSNQQERYREFLQSTITLRAGFVEFLQETQSHGFRFDVVSGGMDFFVHPILEGHVAPEHIFCNHVDFSGETARVTWPHACDVHCLNDCGCCKPTIARQIVSPTDTLIVIGDSVTDFEIAKRADVVYARGQLISLCEAEGIRHVPFETFYDISAYMKGVNV
Function: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalytic Activity: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate Sequence Mass (Da): 24319 Sequence Length: 216 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. EC: 3.1.3.87
Q5L1E1
MTKQLVLFCDFDGTITENDNIIAIMKQFAPPEWEALKDDILAERISVQEGVGKMFSLLPSSLKGEIIDFLRRTTRLRAGFREFVAFTKERGIPLYIVSGGIDFFVYPLLEGLIEPERIFCNGSDFSGETIRITWPHACDGECQNGCGCCKPSLLRKLARPDGYHVVIGDSITDLAVAKQADYVMARDFLLQKCQELGLPHAPFATFFDVIDALQRMEVIV
Function: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalytic Activity: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate Sequence Mass (Da): 24690 Sequence Length: 220 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. EC: 3.1.3.87
B1HYT5
MKPIIFCDFDGTITETDNIFSLMTEFVPQESEKIAKAMMEQTISFKDGLSAMFHLLSTEQKDEVIQYLMDTAVIREGFEDFVRYAQNHDIPFYIVSGGVDFFIEPLVEKYGPFSGIYCNKADFSGEQIKLIYSNSCDEECAKYSTQGCGCCKPSVMRKVAKEEHFKIVIGDSLSDFEAAKQADIVLARDHLIQRCEELHVSYKPFITFHDCLKIVQELMETNHAVPTT
Function: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalytic Activity: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate Sequence Mass (Da): 25970 Sequence Length: 228 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. EC: 3.1.3.87
B0JX47
MSKIVFCDFDGTITAVETFAGMLKEFAPDLSAQIMPQMYARTLTLRRGVRQLLESIPSQKYADILAYAESKPIRPGLAEFLAFLQEQSIPFIIISGGIQGMIETVLKREGLLDKVTAIYGVNLHTQGEYLQVHSDWENETELVAKALIMAKYSGVETIAIGDSVTDITMARRADLVFARDRLIDYLQAENQPYIPWDNFFEIREYLLLRD
Function: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Catalytic Activity: 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate Sequence Mass (Da): 23806 Sequence Length: 210 Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. EC: 3.1.3.87
P24581
MFKIIDLFAGIGGIRLGFEQAFDDVRCVFSSEIDKYAVQTYQANHGGETVCGDITQTDVADIPDHDILSAGFPCQPFSQAGLKKGFADTRGTLFFDIERILLAKKPQAFLLENVKQLKGHDKGRTLQVILAHLQQAGYKVYTEVLKARDFGIPQNRERIYLVGFLNHDVDFRFPQPIGQATAVGDILEAYPDEKYTISDKLWQGYQRRKAENRAAGKGFGYGLFNAESAYTNTISARYYKDGSEILIEQPGKNPRKITPPEAARLQGFPDSFQIPVSDAQAYRQFGNSVCVPVIRAIAEQMKAALSAVSDRKV
Function: A methylase, recognizes the double-stranded sequence 5'-CCNGG-3' and methylates C-2 on both strands. May be the equivalent of dcm in this bacteria, or it may protect the DNA from cleavage by the putative NlaXP endonuclease. Catalytic Activity: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 34843 Sequence Length: 313 EC: 2.1.1.37
Q2FRN2
MANKKSPASGWPIVQGDFHTGDPNSPVAVVTMGSHLDEGAICSAGAAIAGSCKTENLGLEKVIANVISNPNIRFVITCGTEVKGHLSGQSLIALHQNGVDGGKIVGSKGAIPFIENLSADNIKRFQEQVELVDIMESEDLGAISAKIKELTARDPGAFDAEAMIVEIKEEGGGAAEEGGEVRPMSAEVALIHARMKTIQRTITDIGFYDKYAAGVYGGKVEGLMIGLIVSFVIIGLLLVGHGVS
Cofactor: Binds 1 5-hydroxybenzimidazolylcobamide group. Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. Catalytic Activity: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) Location Topology: Single-pass membrane protein Sequence Mass (Da): 25425 Sequence Length: 244 Pathway: One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. Subcellular Location: Cell membrane EC: 2.1.1.86
Q58261
MANKREPAPGWPIVSGEYVVGNPESCVGVVTLGSHGLEQACIDAGAAIAGPCHTENLGIEKVVANYISNPNIRFMILCGSEVQGHITGQCFKALWENGIGDDGGIIGAKGAIPFLENVNKEAVERFRRQIVEVVDLIDCEDIGKITQAIKECLSKDPGAIDEDPFIIELEGGKGGGEEEEGVIKPITPEMAIIESRMRLIGNEMCYNGLLAKWQAGYYNGKIQGIATGLFLMLLIMGILMF
Cofactor: Binds 1 5-hydroxybenzimidazolylcobamide group. Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. Catalytic Activity: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) Location Topology: Single-pass membrane protein Sequence Mass (Da): 25880 Sequence Length: 241 Pathway: One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. Subcellular Location: Cell membrane EC: 2.1.1.86
O32867
MPEKAEPAEGWPVVEGDYVVGDPEAPVHVVTLGSHIEEDILKAAGEDKVAIAGPCKTENIGIEKVIANVIANPNIRFGVLCGAEVTGHLTGQCFKAMYENGVDPDSGEIIGAEGAIPYLENIPEEAVERYRDQIVELVDLIDVEDVDEIVKAIEECVEKDPGAYEEGPMTISLEEEEEEELAEVAGMPVSAETVTVEYRINDVRVGVKSIGAMQRYMAGYLSGRTMGLLIGIISGMIFLFLPMVVLGGV
Cofactor: Binds 1 5-hydroxybenzimidazolylcobamide group. Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. Catalytic Activity: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) Location Topology: Single-pass membrane protein Sequence Mass (Da): 26762 Sequence Length: 249 Pathway: One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. Subcellular Location: Cell membrane EC: 2.1.1.86
O59640
MADKREPAPGWPILKGEYEVGDVKNSVLVITCGSHLPGKPILDAGAACTGSCKTENLGIEKVVAHIISNPNIRYLLVTGSEVKGHITGQSMMSLHANGVKENRIAGALGAIPYVENLNAAAVARFQEQVQVVNLLDTEDMGAITSKVRELASKDPGAFDADPLVVEISEEGEEEEEGGVVRPVSGEIAVLRSRLKAIEARMMDIGNLNKFHSGVHAGKVEGAMIGLTITISLLGLLLLGR
Cofactor: Binds 1 5-hydroxybenzimidazolylcobamide group. Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. Catalytic Activity: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) Location Topology: Single-pass membrane protein Sequence Mass (Da): 25366 Sequence Length: 240 Pathway: One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. Subcellular Location: Cell membrane EC: 2.1.1.86
Q2NI29
MADKKEVIQNWPLETGDYAVGNVESPVAVVSLGSNMNDELVAAGAAISGPLHTENLGIEKVVANIISNSNIRYVLICGSEVQGHITGKTVEALYENGIDEEKKSIIGSPGAIPFVENLPVEAVERFQKQVSIVSMINNEDVSEISSKIDECISNDPGAYDEDAMIVEFNETPEEEFEVDEVTFSDDSAVDLASIVLLEVENRISMMNNEIKQIASLEKISSGYYAGKIEGIVIGFILTLVFLIIIIQGL
Cofactor: Binds 1 5-hydroxybenzimidazolylcobamide group. Function: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. Catalytic Activity: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) Location Topology: Single-pass membrane protein Sequence Mass (Da): 26969 Sequence Length: 249 Pathway: One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. Subcellular Location: Cell membrane EC: 2.1.1.86
A0QTK2
MDTMRQRILVVDDDPSLAEMLTIVLRGEGFDTAVIGDGSQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYVMKPFKPKELVARVRARLRRNEDEPAEMLSIGDVEIDVPAHKVTRQGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPQVVLTVRGVGYKAGPP
Function: Member of the two-component regulatory system MtrA/MtrB, responding to environmental signals (Probable). Controls expression of a number of genes including dnaA, ripA, fbpB and probably itself. Probably plays a role in cell division. PTM: Phosphorylated by MtrB. Sequence Mass (Da): 25318 Sequence Length: 228 Subcellular Location: Cytoplasm
P0AAD2
MATLTTTQTSPSLLGGVVIIGGTIIGAGMFSLPVVMSGAWFFWSMAALIFTWFCMLHSGLMILEANLNYRIGSSFDTITKDLLGKGWNVVNGISIAFVLYILTYAYISASGSILHHTFAEMSLNVPARAAGFGFALLVAFVVWLSTKAVSRMTAIVLGAKVITFFLTFGSLLGHVQPATLFNVAESNASYAPYLLMTLPFCLASFGYHGNVPSLMKYYGKDPKTIVKCLVYGTLMALALYTIWLLATMGNIPRPEFIGIAEKGGNIDVLVQALSGVLNSRSLDLLLVVFSNFAVASSFLGVTLGLFDYLADLFGFDDSAVGRLKTALLTFAPPVVGGLLFPNGFLYAIGYAGLAATIWAAIVPALLARASRKRFGSPKFRVWGGKPMIALILVFGVGNALVHILSSFNLLPVYQ
Function: Involved in the transport of tryptophan into the cell. Catalytic Activity: H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44333 Sequence Length: 414 Subcellular Location: Cell inner membrane
P44614
MIQQKSPSLLGGAMIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDTIVKDLLGKSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGLLSSVKTAVLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLALVIYILWQLAVQGNLPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIADLFKFDDSLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVILFGILNIVAQIGANLGWFASFTG
Function: Involved in the transport of tryptophan into the cell. Catalytic Activity: H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 45018 Sequence Length: 418 Subcellular Location: Cell inner membrane
P9WHH2
METYDIAIIGTGSGNSILDERYASKRAAICEQGTFGGTCLNVGCIPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALSGEDYRRCAPNIDVYRTHTRFGPVQADGRYLLRTDAGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAHVFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTKWELRTHRNVVDGQQRGSGVALRLDDGCTINADLLLVATGRVSNADLLDAEQAGVDVEDGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDTQSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAYGWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAAEMARGQYWIHPALPEVVENALLGLR
Cofactor: Binds 1 FAD per subunit. Function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol. Catalytic Activity: 2 mycothiol + NADP(+) = H(+) + mycothione + NADPH Sequence Mass (Da): 49946 Sequence Length: 459 EC: 1.8.1.15
P38680
MDSQYETKKNDPNAIMPYPESNDEHVGEVRGLGGGIMDKEPEAQEGHAKFHRLGWKRLTVVLIVEAIALGSLSLPGAFATLGMVPGVILSVGMGLICIYTAHVIGQTKLKHPEIAHYADVGRVMFGRWGYEIISFMFVLQLIFIVGSHVLTGTIMWGTITDNGNGTCSLVFGIVSAIILFLLAIPPSFAEVAILGYIDFVSICAAILITMIATGIRSSHQEGGLAAVPWSCWPKEDLSLAEGFIAVSNIVFAYSFAMCQFSFMDEMHTPSDYKKSIVALGLIEIFIYTVTGGVVYAFVGPEVQSPALLSAGPLLAKVAFGIALPVIFISGSINTVVVSRYLIERIWPNNVIRYVNTPAGWMVWLGFDFGITLIAWVIAEAIPFFSDLLAICSALFISGFSFYFPALMYFKITRNDAKSQGKKYFLDALNMLCFVIGMGILGIGTYAAIQDIMDRYDHGKVSKPYSCAPLA
Function: Required for the transport of neutral aliphatic and aromatic amino acids via the N system. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 51162 Sequence Length: 470 Subcellular Location: Membrane
Q02DS7
MSSSPAQTPSRRPSLLGGSMIIAGTAVGAGMFSLPIAMSGIWFGWSVAVFLLTWFCMLLSGMMILEANLNYPVGSSFSTITRDLLGQGWNVVNGLSIAFVLYILTYAYISGGGSIIGYTLSSGLGVTLPEKLAGLLFALAVALVVWWSTRAVDRITTLMLGGMIITFGLSISGLLGRIQPAILFNSGEPDAVYWPYLLATLPFCLTSFGYHGNVPSLMKYYGKDPQRISRSLWIGTLIALAIYLLWQASTLGTIPREQFKGIIAGGSNVGTLVEYLHRITASDSLNALLTTFSNLAVASSFLGVTLGLFDYLADLCRFDDSHFGRFKTALLTFVPPTIGGLLFPNGFIYAIGFAGLAAAFWAVIVPALMARASRKRFGSPLFRAWGGTPAIVLVLLFGVANAVAHILASLHWLPEYR
Function: Involved in the transport of tryptophan into the cell. Catalytic Activity: H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44742 Sequence Length: 417 Subcellular Location: Cell inner membrane
D8RLD3
MAVSSIASIFAAEKSYSIPPVCQLLVSPVLNPLYDAKAESQIDAWCAEFLKLQPGSEKAVFVQESRLGLLAAYVYPTIPYEKIVPVGKFFASFFLADDILDSPEISSSDMRNVATAYKMVLKGRFDEATLPVKNPELLRQMKMLSEVLEELSLHVVDESGRFVDAMTRVLDMFEIESSWLRKQIIPNLDTYLWLREITSGVAPCFALIDGLLQLRLEERGVLDHPLIRKVEEIGTHHIALHNDLMSLRKEWATGNYLNAVPILASNRKCGLNEAIGKVASMLKDLEKDFARTKHEIISSGLAMKQGVMDYVNGIEVWMAGNVEWGWTSARYHGIGWIPPPEKSGTFQL
Cofactor: Binds 3 Mg(2+) ions per subunit. Function: Sesquiterpene synthase converting farnesyl diphosphate to eight sesquiterpenes, with (+)-germacrene D and an unidentified oxygenated sesquiterpene as the major products. Has no diterpene synthase activity. Catalytic Activity: (2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate Sequence Mass (Da): 38990 Sequence Length: 348 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. EC: 4.2.3.77
B6SCF3
MSLSGVPLSAGLAPSPSNKPTNGKGQNIVRRSGNYKPALWDYDYLQSLPTLYAGEAHVEKLNKLKGEVRIMLEKTVTENPLAQLEQIDTLYRLGISYHFQDEIKALLNTIHNNNNNNNNNDDVYATALEFKLLRLYGYTVHSEVFNVFKDEIDKGFKAISLCGDYVKGMLSLYEASFYSFKGETILDEARDFSTKHLQKYVMMRHNNNSKDQSVDDDDDLVILVEYALELPMHWRMIRLEAKWFIDVYSKRRDDMNPTFLELAQIDFNLLQSTYQEDLKHVSRWWSTCKLGERLPFCRDRLVEVFLLAVALKYEAEFGYARRLLTKIGVLVTLMDDIYDVYGTLDELKLLEDAIERWNINELDQLPEYMNIFFVAMYNVVNGIAYDVLKENEILIVKYLKRAWMDACKSYMVEAKWYYSGYTPSLEEYLENGLISITIPLDLIFLYCLTTSPITEDSMEYLLQYPTILGLSGTLFRLVDDLATSSDELKRGDNPKSIQCYMHESGVCENDSREYIKNLISETWKQMNEVRVAKSPLFSQAFIESAVDFVRGAMLLYQKGDGFGTKHDGDAKDKLVSLFFNPIPTP
Cofactor: Binds 3 Mg(2+) or Mn(2+) ions per subunit. Sequence Mass (Da): 67511 Sequence Length: 585 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Subcellular Location: Plastid EC: 4.2.3.-
Q6YSY5
MPVLPWLAAAATTPVRRSPPLPATPRALLRLPASSFPPWSNCAKSGLPPRGPFATAADTPLGGSLPEPEEERDTLLDGALRAARFRDEESRRPDPLFIDPYAAVLLSLDVASEDKDLLALHLMPSAEHYRLVTRYIDDKLQHFISNSDDLRQIVLLTDGMDTRPYRLSWPRLSVVYDVSPRRVFITASQQLRGAGAKISRNCVVLHTSSESPDLQAGLNKNGFNGNRPSLWVLQGLPLFTFKSLEDLLLVIGNLAMKGSIFIGEVPRFTQWGAATDMASEQDRLENLFFTQGFRVSFVHYEEVAKDVGLGLDSPPEIHGRAIFIAEQLRFSDAQMESFRMHFERIEDDADEDGFEEL
Function: Involved in melatonin biosynthesis . Can function as acetylserotonin O-methyltransferase . Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine) . Involved in the regulation of jasmonate- and brassinosteroid-mediated plant growth and defense responses . Catalytic Activity: N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine Sequence Mass (Da): 39828 Sequence Length: 357 Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. Subcellular Location: Plastid
P09795
MIMNDIITVTEAAQLLELTPQRVRTMCKQGSIDAYQSGRTWLIKSSSVEKLMLVNSLSDAQNSYSMLASEPKNKPKALSFFSGAMGLDLGIEQAGFETLLASEIDKAARDTILSNRPNMALIGDIRDYTTEDILKLAGVSSGNEIDLIMGGPPCQAFSTAGKRLGLEDERGNVFIKYLDVALDIRPKYIVIENVRGLLSAPMKHRPHNERGEGLPPLKSEEQPGGVLHYIIRIIKSAGYSVSFNLYNSANFGVPQIRERVIIICSRDGSRVPFLQPTHSEKGEYGLPKWITLRETITNLKNITHEHVLFPEKRLKYYRLLKEGQYWKHLPEDLQKEALGKSFFLGGGKTGFLRRVAWDRPSPTLVTHPAMPATDLAHPDELRPLSVQEYKVIQQFPEEWVIKGKLLDKYRQLGNAVPIGLGLAVGKNILDHMNGRKIESFPNFRYSRYKNTSDLDIFGELV
Function: A methylase that recognizes the double-stranded sequence 5'-GGWCC-3', methylates C-4 on both strands, and protects the DNA from cleavage by the SinI endonuclease. Catalytic Activity: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 51767 Sequence Length: 461 EC: 2.1.1.37
O31073
MNHELPVISLFSGAGGLDCAIESCAEPPLVQDGSGSPLRVAVATDYEQTALDTLSANFPHTKTLCGDIQTIPTAELLEAGGLKPGDPTLVIGGPPCTPFSKSGFWIEEKRNSADPNASLLDEYVRVVRESKPEAFILENVQGLTYKTHQAQFDRLIAGLKDAGYNPTFRVLLAAEYGVPQLRRRVFVVGRRDGKAFHFPETTHSGESERDRVIDHTKIPFTSLREALAGLPDVPEAGEVVEGTYAELAAEVPPGQNYLWHTDRYGGRNEFKWRSRYWTFLLKADPDRPSTTLQAQPGPWVGPFHWENVKNANGEERARRFRVAEMKRIMTFPDEFVFTGVKREVQRQIGNPVPVELGKVVVRALMEQLGYLDSRGTTIPSQAGHEQLELI
Function: A beta methylase recognizes the double-stranded sequence 5'-GAGCTC-3', methylates C-4 on both strands, and protects the DNA from cleavage by the SacI endonuclease. Catalytic Activity: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 43293 Sequence Length: 390 EC: 2.1.1.37
Q53609
MHSEAREAEARRLLLQETLDAERTFLERNQWGQFATPPSLAGEIMRYTIDLHEETRINFLEPSCGSGSFFSALLRNLGDKKIEHAVGVELDPRFSKAASDLWTGQGLRVIEGDFTSPSLVSGPVASLLVANPPYVRHHHLGIDQKRDLVARCADQLGIKPSGLSGLYLYFVLLSHRLLRADAVSTWLIPSEFMDVNYGTALKEYLATRVQLVRIHQYDAAEVQFDDALVTSSVVVFRNSPPRPGHTAEFSFGGTLSEPKVTHQIPSAALTPEAKWSRYVTGVMPADINLKQTGPKLSDFFKIRRGLATGSNAFFIIPRSEAERLGIKRNFLRPILPSPRKLKGDAITADASGWPDIPEQLALLDCPLPIEDLLLENPALAAYLSTADEKIRGGYLVSKRSPWYKQEQREPAPILLTYMGRGKDDQHPLRFIRNDSDAVATNMYLMLYPTALLQRYLAGDPERIKQVHKALLAITAADLRGGGRVYGGGLHKMEPKELAALPADGIATLDPVLREDISMVSVPPRKRTGRPQMPGPSASEVRAWARANGVCVPDRGRLRPEVWDAWRQAHAGEASPLNIDAGDQVALW
Function: A gamma subtype methylase that recognizes the double-stranded sequence 5'-GTCGAC-3', methylates A-5 on both strands, and protects the DNA from cleavage by the SalI endonuclease. Catalytic Activity: a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 64975 Sequence Length: 587 EC: 2.1.1.72
O52692
MSGRDFGYVIQSSAALWNRLSTFSQRGKALDTRLADIKKALGKPYYETSDVLLYHGDSLELLKSMPQQIFDLTVTSPPYNIGKEYEGVLSIEEYISWCETWMSRVHRATSAGGAFWLNVGYVPVPNQGKAVPIPYLLWDKSPFYMIQEVVWNYGAGVASRKSFSPRNEKFLWYVRDPLNYYFDLDSVRDPNVKYPNQKKNGKLKCNPLGKNPTDVWQFPKVTSGAKRSSVERTAHPAQFPSAVIERVIKACSPSDGVILDPFLGSGTTSLTARKQGRCSVGIEIREDYLDIAVGRLEAEAQSLF
Function: A methylase that recognizes the double-stranded sequence 5'-AGTACT-3', methylates C-5 on both strands, and protects the DNA from cleavage by the ScaI endonuclease. Catalytic Activity: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 34187 Sequence Length: 304 EC: 2.1.1.113
O64471
MEGDQETNVYTLVARKPSFDLPTACPNCLPAYIYLKLAQLPFELAFNSTFPDSDELPYFESDTYVAYNNEDGGVIEKLKKDGIVNLDSQLQSLSDYLSLKALIVSWLEEALTYEIWVGTEGISTSKIYYSDLPWVISKVLFYKQTYLAKNRLGITKENAEQREKQIYKRASEAYEALSTRLGEQKFLFEDRPSSLDAFLLSHILFIIQALPVTSVLRCKLLEHSNLVRYAEKLKSEFLEASSSSPSPPLHSFPSSFPRKSSKPKSKPKVEKTEEEKKFKKRARFFLAAQFLAVVIYVSVMGGGSSDELEYEDEDD
Function: Involved in transport of proteins into the mitochondrion. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 35854 Sequence Length: 315 Subcellular Location: Mitochondrion inner membrane
P43121
MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH
Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 71607 Sequence Length: 646 Subcellular Location: Membrane
Q9EPF2
MGLPRLVCAFLFAACCCCRSATGVPGEEKQPTPTPDPVEVEVGNTALLKCGPAHPSGNFSQVEWFLIHKERQIPIFRVHQGKGQSEPGEYEHRLSLHGPGATLALSQVTPHDDRMFLCKSKQPRPQDHYVQLQVYKAPEEPTIQANVLGIHVDIQELKEVATCVGRNGYPIPQVIWYKNGRPLQEEENRVHIQSSQTVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNRMKESKEVTVPVLYPAEKVWVEVEPVGLLKEGDHVKIRCLTDGNPQPHFTINKKNPSTEEMEEESTDENGLLSLEPAQKHHSGVYQCQSLDLETTVMLSSDPLELLVNYVSDVQVDPTAPEVQEGDSLTLTCKAESNQDLEFEWLRDKTGQLLGKGPILQLNNVKREAGGRYLCVASVPSVPGLNRTRRVSVGIFGSPWMAAKERKVWAQENAMLNLSCEASGHPQPTISWNINGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTVIILKLVTLTTLTPDSSQTTGLSTPTVSPHSRANSTSTEKKLPQQESKGVVIVAVIVCTLVLAVLGATLYYFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH
Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity). Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 71327 Sequence Length: 648 Subcellular Location: Cell membrane
Q8WML4
MTPDIQAPFLSLLLLFPVLTVANVPTLTTSDSINPRRTTPVSTTQSSPTSSPTKETSWSTTTTLLTASSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPAASPGHDGASTPTSSPAPSPAASPGHNGTSSPTGSPAPSPTASPGHDSAPSLTSSPAPSPTASPGQHGASSPTSSDTSSMTTRSMSSSMVTSAHKGTSSRATMTPVSKGTPSSVPSSETAPTAASHITRTAASSPSIALSTSSNPKTSQQLSVRVSLYFLSFRITNLQFNSSLENPQTSYYQELQRSIWGLILQIYKQRDFLGLSEIKFRPGSVVVELTLAFREGTTAEWVKAQFSQLEAHAASYNLTISGVSVYSAPFPSSAQAGSGVPGWGIALLVLVCVLVALAIIYLIALVVCQCGRKKCEQLDVFPTLDAYHPMSEYSTYHTHGRYVPPGSTKRSPYEEVSAGNGGSNLSYTNLAATSANL
Function: The alpha subunit has cell adhesive properties. May provide a protective layer on epithelial cells against bacterial and enzyme attack (By similarity). PTM: Highly glycosylated (N- and O-linked carbohydrates and sialic acid). O-linked glycosylation consists mainly of GalNAc, galactose, and sialic acid. The ratio from pools of milk from different dairy breeds is GalNAc: GlcNAc:galactose:mannose:sialic acid is 14:1:10:1:15. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 58092 Sequence Length: 580 Subcellular Location: Apical cell membrane
Q29435
MTPGTQSLFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSMPSSTEKKVVSMTSSVLSSHSPGSGSSTTQGQDVSLAPATEPASGSAATWGQDVTSVPVTRPAPGSTTSPAQDVTSAPDTRPALGSTAPPVHGVTSAPDTRPTLGSTAPPVHGVTSAPDTRPTLGSTAPPVHNVTSASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLTSHSTKTDASSTHHSTVSPLTSSNHSTSPQLSIGVSFFFLSFHISNLQFNSSLEDPSTNYYQELQRDISELILQIYKQGDFLGVSNIKFRPGSVVVQSTLAFREGTTNVHDVEAQFNQHKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARDAYHPMSEYPTYHTHGRYVPPSSTNRSPYEKVSEGNGGSSLSYTNPAVAATSANL
Function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack (By similarity). PTM: Probably both N- and O-glycosylated (in repeat region). Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 49372 Sequence Length: 475 Subcellular Location: Apical cell membrane
Q60528
MTPGIRAPFLLTLLLALVTDPNSVALSQDTSSSSTLNTTPVHSGSSAPATSSAVDSATTPGHSGSSAPPTSSAVNSATTPGHSGSSAPPTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPPTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPVTSSAVDSATTPVHSGSSAPPTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPVTSSAVNSATTPVHSGSSAPPTSSVVNSATTPVHSGSSAPPTSSAVNLATTPVHSGSSTPATNSTTDSATTPVPPGSSMQTTEAISGSANTPIHNGSLVPTTSSALVPTTSAAHSGASAMTNSSESDLATTPIDSGTSISTTKAPATTPVHNGSLVPTTSSVLGSATTLIHNDTSTMATTTPVGNGTQSSVPSRHPVTPTPPAVSSNSTIALSTYYSTALSPAFSSHAAPQVSVGVSFFLLSFHIWNHQFNSSLEDPSSNYYQELKRNVSGLFLQVFSRAFLGISTIEFRSGSVVVDSTVIFREGAVNASEVKSQLLQHEQEAEEYNLAISKINVGEMQFPSSAQSWPGVPGWGIALLVLVCILVALAIVYLIALAVCQCRRKNYGQLDIFPIQDSYHPMSEYPTYHTHGRYVPPGSTKRSPYEEVSAGNGSSLSYTNPVVATTSANL
Function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack (By similarity). PTM: Probably both N- and O-glycosylated (in repeat region). Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 67617 Sequence Length: 676 Subcellular Location: Apical cell membrane
Q02496
MTPGIRAPFFLLLLLASLKGFLALPSEENSVTSSQDTSSSLASTTTPVHSSNSDPATRPPGDSTSSPVQSSTSSPATRAPEDSTSTAVLSGTSSPATTAPVNSASSPVAHGDTSSPATSLSKDSNSSPVVHSGTSSAATTAPVDSTSSPVVHGGTSSPATSPPGDSTSSPDHSSTSSPATRAPEDSTSTAVLSGTSSPATTAPVDSTSSPVAHDDTSSPATSLSEDSASSPVAHGGTSSPATSPLRDSTSSPVHSSASIQNIKTTSDLASTPDHNGTSVTTTSSALGSATSPDHSGTSTTTNSSESVLATTPVYSSMPFSTTKVTSGSAIIPDHNGSSVLPTSSVLGSATSLVYNTSAIATTPVSNGTQPSVPSQYPVSPTMATTSSHSTIASSSYYSTVPFSTFSSNSSPQLSVGVSFFFLSFYIQNHPFNSSLEDPSSNYYQELKRNISGLFLQIFNGDFLGISSIKFRSGSVVVESTVVFREGTFSASDVKSQLIQHKKEADDYNLTISEVKVNEMQFPPSAQSRPGVPGWGIALLVLVCILVALAIVYFLALAVCQCRRKSYGQLDIFPTQDTYHPMSEYPTYHTHGRYVPPGSTKRSPYEEVSAGNGSSSLSYTNPAVVTTSANL
Function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. PTM: Probably both N- and extensively O-glycosylated (in repeat region). Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 64539 Sequence Length: 630 Subcellular Location: Apical cell membrane
Q05049
APTTAAAVAATGKDTTAAAEGSAAAEKTAAAGEVSAPPTAAVAATGEDATTAAATAAAETTAAAGEAPTTTTAPATTAAGKAPTTAAATAPTTAAAGAPTTATGKAPATAAAPVPTTAASKAPTTAAAATHSTAAAAAPTTAASAAKSKERSTSSSSEEEHCHVKPSKREMCGSKGITKKQCKKKNCCFDPKGHGGIHCFHRKPKGHSHEEHTTTTTKAPTTIQIATTTTTPTTTTTTTKATPTTTTTTKATPTTTTTTKATTTTTTPTTTTTTTKATTTPTTTTTTTPTTTTTKATTTTTTTSGECKMEPSKREDCGYSGITESQCRTKGCCFDSSIPQTKWCFYTLSQVADCKVEPSQRVDCGFRGITADQCRQKNCCFDSSISGTKWCFYSTSQVAATKTTTTPTTTTTPTTTTTTKATTTTPTTTTTTPTTTTTTTTTTKATTTTPTTTTPTTTTTKATTTTPTTTTTTPTTTTTKATTTTPTTTTTTPTTTTTKATTTTPTTTTTTTTTTKATTTTTSGECKMEPSKRADCGYPGITESQCRSKGCCFDSSIPQTKWCFYSLPQVADCKVAPSSRVDCGFGGITADQCRQRNCCFDSSISGTKWCFYSTSQGNAMCSGPPTKRRDCGYPGISSSVCINRGCCWDNSVMNVPWCFYRT
Function: Could be involved in defense against microbial infections. Protects the epithelia from external environment. PTM: Extensively O-glycosylated. Sequence Mass (Da): 67775 Sequence Length: 662 Subcellular Location: Secreted
Q9SS43
MRQNLKKVAQIKVDESKKLFPYVFRVKTSCGNCAKRSKPKLIYLLIFSLISSCFVFAPQLLCFPYPSALFLIDSSIKEIENRVSESNIESPKTSQKEESISCDRTGYRSDICFMKGDIRTHSPSSSIFLYTSNDLTTDQVLQEKIKPYTRKWETSIMETIPELKLVTKDMKLFGDKRKCEVIHEVPAVLFSTGGYTGNLYHEFNDGLIPLYITSKRFNKKVVFVIAEYHKWWEMKYGDVLSQLSDYSLIDFNKDKRTHCFKEAIVGLRIHGELTVDPSQMQDDGTTINEFRNVLDRAYRPRINRLDRLEEQRFHARLAQRRKAKRPKLALFSRTGSRGITNEDLMVKMAQRIGFDIEVLRPDRTTELAKIYRVLNSSKVMVGVHGAAMTHFLFMKPGSIFIQIIPLGTDWAAETYYGEPAKKLGLDYNGYKILPRESSLYEKYDKDDPILKDPNSITKKGWQFTKGIYLNDQKVRLDLHRFKKLLIDAYAKSIR
Function: Glycosyletransferase required for the proper composition and structural properties of released seed coat mucilage . Required for the production of highly branched xylan polymers in seed coat mucilage . Facilitates the addition of xylose residues directly to the xylan backbone . Xylan with xylose side chains seems to be necessary for pectin attachment to the seed surface . Essential for xylan synthesis in seed coat epidermal (SCE) cells . Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 57287 Sequence Length: 494 Subcellular Location: Golgi apparatus membrane EC: 2.4.-.-
Q5SSG8
MKMQKGNVLLMFGLLLHLEAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFSTVSSGISIATNSESSTTSSGASTATNSESSTPSSGASTATNSDSSTTSSGASTATNSDSSTTSSEASTATNSESSTTSSGASTATNSESSTVSSRASTATNSESSTTSSGASTATNSESRTTSNGAGTATNSESSTTSSGASTATNSESSTPSSGAGTATNSESSTTSSGAGTATNSESSTVSSGISTVTNSESSTPSSGANTATNSESSTTSSGANTATNSDSSTTSSGASTATNSESSTTSSGASTATNSESSTTSSGASTATNSGSSTTSSGTSTATNSESSTVSSGASTATTSESSTTSSGASTATNSESSTVSSGASTATNSESSTTSSGANTATNSGSSVTSAGSGTAALTGMHTTSHSASTAVSEAKPGGSLVPWEIFLITLVSVVAAVGLFAGLFFCVRNSLSLRNTFNTAVYHPHGLNHGLGPGPGGNHGAPHRPRWSPNWFWRRPVSSIAMEMSGRNSGP
PTM: O-glycosylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 54228 Sequence Length: 566 Subcellular Location: Cell membrane
Q2YDH0
MSGLSRPLLLAVGCLAALCVITAAGNTTLAPNVTTASSPPPTTTTVPVSPTTLSPLPVTTPAPDICGSRNSCVSCVDGNATCFWIECKGKSYCSDNSTAGDCKVVNTTGFCSVPTTTPTPTNSTAKTTTLPSTTTTSTTATTSGTTNTTLSPTIQPTRKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL
Function: Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). PTM: Highly N- and O-glycosylated; contains sialic acid. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 20347 Sequence Length: 198 Subcellular Location: Lysosome membrane
Q04900
MSRLSRSLLWAATCLGVLCVLSADKNTTQHPNVTTLAPISNVTSAPVTSLPLVTTPAPETCEGRNSCVSCFNVSVVNTTCFWIECKDESYCSHNSTVSDCQVGNTTDFCSVSTATPVPTANSTAKPTVQPSPSTTSKTVTTSGTTNNTVTPTSQPVRKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL
Function: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). PTM: Highly N- and O-glycosylated; contains sialic acid. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 20917 Sequence Length: 197 Subcellular Location: Lysosome membrane
Q969V5
MESGGRPSLCQFILLGTTSVVTAALYSVYRQKARVSQELKGAKKVHLGEDLKSILSEAPGKCVPYAVIEGAVRSVKETLNSQFVENCKGVIQRLTLQEHKMVWNRTTHLWNDCSKIIHQRTNTVPFDLVPHEDGVDVAVRVLKPLDSVDLGLETVYEKFHPSIQSFTDVIGHYISGERPKGIQETEEMLKVGATLTGVGELVLDNNSVRLQPPKQGMQYYLSSQDFDSLLQRQESSVRLWKVLALVFGFATCATLFFILRKQYLQRQERLRLKQMQEEFQEHEAQLLSRAKPEDRESLKSACVVCLSSFKSCVFLECGHVCSCTECYRALPEPKKCPICRQAITRVIPLYNS
Function: Exhibits weak E3 ubiquitin-protein ligase activity . E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates . Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation . Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion . Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations . Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization . Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway . May also be involved in the sumoylation of the membrane fission protein DNM1L . Inhibits cell growth . When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis . Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response . Can mediate RIGI sumoylation and disrupt its polyubiquitination . PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Location Topology: Multi-pass membrane protein Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Sequence Mass (Da): 39800 Sequence Length: 352 Domain: The zinc finger domain is required for E3 ligase activity. Pathway: Protein modification; protein ubiquitination. Subcellular Location: Mitochondrion outer membrane EC: 2.3.2.27
Q8VCM5
MESGSRPSLGQVILLGTSSMVTAVLYSIYRQKAQVAQELKGAKKIHLGEDLKGILSEAPGKCVPYAVIEGAVRSVKETLNSQFVENCKGVIQRLSLQEHKMVWNRTTHLWNDYSKIIHQRTNTVPFDLVPHEDGVAVSVRVLKPLDSVDLGLETVYEKFHPSVQSFTDAIGHYISGERPKGIQETEEMLKVGATLTGIGELVLDNNAVRLQPPKQGMQYYLSSQDFDSLLHRQESSVRLWKILVLVFGFATCATLFFILRKQYLHRQERLRQQQLQEEFLEHEAQLLSQASPEDRESLKSACVVCLSNFKSCVFLECGHVCSCRQCYLALPEPKRCPICRREITRVIPLYNS
Function: Exhibits weak E3 ubiquitin-protein ligase activity (By similarity). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation (By similarity). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-27' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (By similarity). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (By similarity). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (By similarity). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway . May also be involved in the sumoylation of the membrane fission protein DNM1L (By similarity). Inhibits cell growth (By similarity). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (By similarity). Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity). Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity). PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. Location Topology: Multi-pass membrane protein Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Sequence Mass (Da): 39835 Sequence Length: 352 Domain: The zinc finger domain is required for E3 ligase activity. Pathway: Protein modification; protein ubiquitination. Subcellular Location: Mitochondrion outer membrane EC: 2.3.2.27
Q08750
MGFVDFFETYMVGSRVQFKQLDISDWLSLTPRLLILFGYFYLHSFFTAINQFLQFINTNSFCLRLHLLYDRFWSHVPIIGEYKIRLLSRALTYSKLKIIPTLDKVLEAIEIWFQLHLVEMTFEKKKNVQIFITEGSDDLNFFKDSKFQTTLMICNHRSVNDYTLINYLFLKSCPTKFYTKWEFLQKLRKGEDLAEWPQLKFLGWGKMFNFPRLDLLKNIFFKDETLALSSNELRDILERQNNQAITIFPEVNIMSLELSIIQRKLHQDFPFVINFYNLLYPRFKNFTTLMAAFSSIKNIKRKKNRNNIIKEARYLFHRELDKLVHKSMKMESSKVSDKTTPPMIVDNSYLLTKKEEISSGKPKVVRINPYIYDVTIIYYRVKYTDSGHDHTNGDLRLHKGYQLEQISPTIFEMIQPEMESENNIKDKDPIVVMVNVKKHQIQPLLAYNDESLEKWLENRWIEKDRLIESLQKNIKIETK
Function: Involved in the organization of the outer spore wall layers and especially in the assembly of the chitosan layer. Location Topology: Single-pass membrane protein Sequence Mass (Da): 57237 Sequence Length: 479 Subcellular Location: Membrane
P50276
MSEGRTFLSQLNVFNKENYQFSSSTTKKEVSNSTVDADNGASDFEAGQQFATELDQGEKQLGILSCIGLICNRMLGTGVFAVSSTIYTLCGSVGLALIMWAVGAIIAISGLYVYMEFGTAIPKNGGEKNYLEAIFRKPKFFITCMYAAYIFFLGWAAGNSINTAIMFLTAADTEVTKWNQRGIGVAVVFFAFLINSLNVKIGLYLQNILGIFKIGIVLFISITGWVALGGGLKDGYQSHNFRNAFEGTETATAYGIVNALYSVIWSFVGYSNVNYALGEVKNPVRTLKIAGPTSMVFLAIIYIFVNIAYFAVVPKDKLISSKLILAADFFDIVFGGQAKRAAAALVGLSALGNVLSVIFSQGRIIQQLGREGVLPFSNFFASSKPFNSPMVGLFQHFIVCTVTILAPPPGDAYLLVQNLISYPMNIINFAISAGLLWIYWQRRQGKIEWNPPIKAGVFVTGFFTLSNLYLIIAPYVPPSNGESVYSSMPYWIHCVIAWGIFFFGGVYYVVWAQLLPRWGHYKLVSKDVLGEDGFWRVKIAKVYDDTIGDVDTQEDGVIETNIIEHYKSEQEKSL
Function: High affinity permease for methionine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 63221 Sequence Length: 574 Subcellular Location: Membrane
P04939
MKLLLPLLLLLCLELTLVCIHAEESSSMERNFNVEQISGYWFSIAEASYEREKIEEHGSMRAFVENITVLENSLVFKFHLIVNEECTEMTAIGEQTEKAGIYYMNYDGFNTFSILKTDYDNYIMIHLINKKDGKTFQLMELYGREPDLSLDIKEKFAKLCEEHGIIRENIIDLTNVNRCLEARE
Function: Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females. PTM: Glycosylated. Sequence Mass (Da): 21465 Sequence Length: 184 Subcellular Location: Secreted
P38734
MEPLLFNSGKANPSQDVFIDVEVGDITTKYGSTNTGSFSSMDTVEAQAIKAETARFMEVPQGRHLGVFSTVVLFVSRIMGSGIFAVPSVILLNTGGNKLIYFAIWVFSAAIAFAGLYLFLEFGSWIPKSGGRKNFLERSFERPRLLISVVFSCYSVLTGYALTGSIVFGKYVLSAFGVTDDSWSKYVSISFIIFAVLIHGVSVRHGVFIQNALGGLKLIMIVLMCFAGLYTLFFYKSTGQVAWDLPVTQVEKDSLLSVSSIATAFISSFFCFSGWDTVHTVTSEIKNPVKTLKVSGPLSLIICFVCYTMMNVAYLKVLTYEEIVSAGPLVGSVLFTKLFGPRVGGKFIAFSIAISAASNILVVIYSISRVNQEIFKEGYLPFSIHMSKNWPFDAPLPSISLCGFITIAWILILPKEGESFNYLVSMDGYGNQFFLLLVAIGLFIWRFKHKNEVPEIRASTFGVLAIITLSLYMLMAPFFADPSLNRVGFLPPYQIMSLLVIVACFFFWLVKFVLLPKFFHYKLLPKITYLHDGLIVTEWVKKPCLC
Function: Very low affinity permease for methionine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60620 Sequence Length: 546 Subcellular Location: Membrane
Q39K93
MQVTVNERDAVQSVATAHPAANGESHGHGMDKLVIEGGHRLSGEIVVSGAKNAALPILCAGLLTGDPVDLDNVPNLKDVRTTLKVLNQMGVKSETDGCRVQLDASRVDNLVAPYELVKTMRASILVLGPLLARFGEAKVSLPGGCAIGARPVDQHIKGLQAMGAEISIEHGFIEARAKRLKGARIVTDMITVTGTENLLMAATLADGETVIENAAREPEVSDLAHLLVAMGAKIDGIGTDRLVIQGVERLHGARHSVIPDRIEAGTFLCAVAAAGGDVRLTGVRPHILDAVIDKLREAGVSIEEGDSWLRVKMDRRPSAVTIRTSEYPAFPTDMQAQFMALNTVATGTAQVVETIFENRFMHVQELNRLGANITIDGNTALVTGVDKLSGANVMATDLRASASLVIAGLRAEGETLVDRIYHLDRGYDRMEAKLTAVGANVRRLSGSQA
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 47666 Sequence Length: 449 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
Q3JMZ4
MQVTVNEHDAVERVATATPAGNREAHAHGTDKLAIEGGRRLAGEIAVSGAKNAALPILCAGLLSAEPVRLDNVPDLKDVRTTLALLGQMGMREETDGARVVLDASRVDNPVAPYELVKTMRASILVLGPLLARFGYAKVSLPGGCAIGARPVDQHIKGLQAMGAEIHIEHGYIEARAKRLSGARIVTDMITVTGTENLLMAATLADGETVIENAAREPEVTDLAHLLVAMGAKIDGIGTDRLVIQGVERLHGATHAVIPDRIEAGTFLCAVAAAGGDVTLTGMRAHILDAVIDKLREAGATIDEGVDTLRVRMDGRPSAVAIRTSEYPAFPTDMQAQFMALNAVAQGAAQVTETIFENRFMHVQELNRLGANIAVDGNTALVTGVPKLSGASVMATDLRASASLVIAGLCAQGETLVERIYHLDRGYDRMETKLTAVGANVRRISGSEA
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 47283 Sequence Length: 449 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
Q9PP65
MTYLEIEGTNHLSGNVTISGAKNAALPLIVSSILAKNEVKINNVPNVADIKTLISLLENLGAKVNFQNNSALLNTNTLNQTIAKYDIVRKMRASILTLGPLLARFGHCEVSLPGGCAIGQRPIDLHLLALEKMGANIQIKQGYVVASGNLKGNEILFDKITVTGSENIIMAAALAKGKTKLLNVAKEPEVVQLCEVLKDAGLEIKGIGTDELEIYGSDGELLEFKEFSVIPDRIEAGTYLCAGAITNSKITLDKVNATHLSAVLAKLHQMGFETLITEDSITLLPAKEIKPVEIMTSEYPGFPTDMQAQFMALALKANGTSIIDERLFENRFMHVSELLRMGADIKLNGHIATIVGGKELNAADVMATDLRASSALILAALAAKGTSKVHRIYHLDRGYENLEEKFKDLGAKITRLEE
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 45186 Sequence Length: 418 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
Q7U5R6
MTVASTVSQEILNHCLAIEGQRRLQGVLKVSGAKNSALVLMTASLLTEELVELINVPNLTDIAGMGRILSALGVQVEHSGNGVALNAGNLTSHEPPYELVNSLRASFFCIGSLLGRLGHARVPLPGGCRIGARPVVEHIRGLKALGAHVSVEHGIVSACVKGSKKRLTGAPIVLDCPSVGATETLLMAAVLATGTTTIENAAHEPEVQDLANLLIQMGADISGAGGPVITIHGVERLAGVSNYPVIPDRIEAGTFLIAAAITRSPLRVEPVIPEHLSAVLQKLRDCGCQLEIDQTGISITPGDIQAVDITTQPFPGFPTDLQAPFMALMATAQGTSVISEKIYENRLQHVAELQRMGASIRVDGSTAIVEGVAQLSAAPVTGSDLRAAAAMVLAGLAANGTTKVSGLKHLYRGYDKVEAKLNAVGAQLERQQG
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 45071 Sequence Length: 433 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
Q6MEP6
MDVLKITGGIPLKGQVKAAGAKNAMTKLLVASLLSDKKCTFYNVPNIGDVEVTVSLCQEIGMEVRWDRAAGIMEVITKELKTSYIPQRFSGSNRIPILMIGALLGRTDQDIIVPTAGGCPIGQRPVDFHIQALEQLGAVIEYRGMKREGAYFAHAHNGLKGTLITLPYPSVGATENTILAGITARGVTVIKNAAIEPEIVELILFLQKLGAIITIDVDRTIRIQGTRRFYEVEHTVIPDRIEAASWGMAAISSKGKVFVEGAQHLNMITFLNKLREVGGGFDVRSNGIEFFYDGPLQGGLHLETDVHPGFMTDWQQPFVVLLTQSSGTSVVHETVYENRFGYTDTLKEMGADITPFRQCLGGKSCRFASQSFSHSAIIKGATPLVGKEIRIPDLRAGFAYIMAALIANDTSTISGLPFIQRGYENFIGKLADLGANVSLVEEEKNVKEMPENSSKLPLFAELQVN
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 50688 Sequence Length: 465 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
P57821
MQKFRVYGQSRLRGSVNISGAKNAALPILFAAILAQEPVKLTNVPELKDIETTLKILRKLGVVVERDAEGAVHLDASKIDHFVAPYELVKTMRASIWALAPLVARFHRGQVSLPGGCSIGARPVDLHISGLERLGASIILEDGYVKAYVDHCLVGTRIVMEKVSVGATLSIMMAATLAKGKTIIENAAREPEITDTALFLNKMGAKIVGAGTDTITVEGVERLGGCEHSIVPDRIETGTFLVAAAISGGRIECKNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPRAVNIRTAPYPGFPTDMQAQFTLLNMVACGTSIITETIFENRFMHIPELIRMGGKAEIEGNTAICHGVDHLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRGYERIEEKLRGLGARIERFSAQSEES
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 45812 Sequence Length: 425 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
Q4FNE4
MKKLEVFGAAKLKGQIRISGSKNASLPILAATLLSNKKISLANLPRVKDIETMILLLKSLGSIIEDNKKELIIKNTKQTKTFAAYSLVKTMRAGILVLGPLLAKFGKAKVSLPGGCAIGTRPVDIHLQALSKLGVKYKIIQGYVHANAPKGLIGANIKFPKVSVGATENLIIAACLAKGKTTLSNCAIEPEIKDLVNFLINMGCNIKWTAKRTVRIEGVNNLKELDYSVMPDRIEAGTYLIAAALTEGNLKITGIDPKIISTEINILKKVGSKITLKKNEILIQGSKKIKNINIKTSPYPGFPTDLQAQMMVLLCKANKRSHIKEEIFENRFMHVAELNRMGAKISINGNQASIEGNIKFEAAELMATDLRASVSLILAALAAKGKSVINRIYHLDRGYEDIEKKLKKVGAKIKRIN
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 45469 Sequence Length: 417 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
A4SV13
MDKLRMTGGTPLNGEVTIAGAKNAALPILCACLLTDQPVVLRNLPDLQDVRTMLKLLQEIGVVVSFPDANNPNHVILNAAVIKSSEATYEMVKTMRASILVLGPLLARMHSAKVSLPGGCAIGARPVDQHIKGLKAMGASIKIKSGYIQAETKPTTERLKGASILTDMITVTGTENLLMAATLASGTTILENAAREPEVGDLAELLVKMGAKITGIGSDRLVIEGVEKLHGAEHSVIPDRIEAGTFLCAVAAAGGEVLVKHCRPDTLDAVIVKLKEAGLKMEIGPDWIKASMQGRPKAVSFRTSEYPAFPTDMQAQLMAVNAVANGNSTITETIFENRFMHVQELNRLGADIAIEGNTAIAQGVERLSGAIVMATDLRASASLVIAGLAAQGETQVDRIYHLDRGYDRMEQKLTRLGANIERIK
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 45168 Sequence Length: 424 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
A1VK35
MDKLRIKGGKSLAGSVDISGAKNAALPELCAALLTAETVTLQNVPGLQDVATMLKLIRNMGVEAERSAHAPGTVILNAGPLSSPEAPYELVKTMRASVLALGPLLARFGEATVSLPGGCAIGSRPVDQHIKGLQAMGADIIVEHGYMLARLPKGQTRLKGAAITTDMVTVTGTENFLMAATLAEGETILENAAQEPEIGDLAEMLIKMGAKIEGHGSRRIRIQGVERLHGCTHQVVADRIETGTFLCAVAAAGGDVVLNHGRADHLEVVIEKLREAGATVTAGEGFIRIQASGRMKAQSFRTTEYPGFPTDMQAQFMALNAIAQGTSTVTETIFENRFMHVNEMVRLGAKIQIEGKVCVINGVEQLSGATVMATDLRASASLVIAGLVASGETFVERIYHLDRGYDQMEAKLRGIGADIERMKA
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 44921 Sequence Length: 424 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
Q7MUW1
MASYVIEGGNSLKGEILVQGAKNEALQIISATLLTDQEVVVRNIPDILDVNNLIDLLRNMGVKVKRPTRDTCVFQADNVNLDYIKSEQFLEKSRALRGSVLLVGPLISRFGYAIFPKPGGDKIGRRRLDTHLVGIQALGATCDYHSDMQAYELTASRLSGTYMLLDEASVTGTANILMAAVLADGITTIYNAACEPYLQQLCKMLLSMGAHIEGVGSNLLRIEGVQSLHGCEHKMLPDMIEVGSFIGMAAMTASELLIKDVSVPDLGIIPASFRRLGIAVEQQGDDLFIPKQEHYEIETFMDGSIMTIADAPWPGLTPDLLSVFLVVATQAKGSVLIHQKMFESRLFFVDKLIDMGAQIILCDPHRATIIGLDKRVPLRAATMVSPDIRAGIALLIAAMSAEGTSIIHNVEQIDRGYQSIDTRLNAIGARISRL
Function: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Catalytic Activity: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 47248 Sequence Length: 434 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 2.5.1.7
Q81WD1
MEQLVNELIQANVGRVLVDEPLARYTTMKIGGPADILIVPKRVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVVIRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGTIDWLTHGEMEFSYRTSVLQTKRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIEKAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIGR
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 33016 Sequence Length: 301 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q8NTF4
MNDFKKVSESLETALRNEFDFRFATEVSLKEISRWRIGGPAAVFAEPSSINEICALLAFMKNRPEPVVVVGGTSNILFDSDGFGGLVIKLGENFSNFIIEGSRIRAQAGASVPQLVRAVATEGLEGIVHAGGIPGTVGGLVVMNGGTQRRGIGEHVTKVLVTDAEGSIRELNANELQFTYRNSVLKNSETTVLEVELLLKPGNAGELLAELETILDQRSQKFPEDLPNCGSTFLSDPAMYSIVGPPGKAIEDAGLKGLRRGSAEISMQHANFIVNHGDASDDDILWLISAVRKEVYSRTGFVMDCEVLYLSYSGDFRPAHEVADEQWPDIDLVRN
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 36371 Sequence Length: 335 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q67RL6
MDVHGAAYATHGKGVTGIAALDIQQGVSLRDYSTMRLGGWAAYLAHVRSPAEVEEGIAWAEARHLPVIMVGGGSNIIWRDEGFAGLVLVNRIPGFELADQGGHLLLTVGAGENWDSVVARAVAAGASGIERLSLIPGTAGATPVQNVGAYGQEIADVLVSVDAYDRQERRFVRIPAAECAFGYRRSRFNQADRGRFFITALTLRLLREPPRAPFYPALGRYLEERGLTHPTVQQVRDAVIAIRRAKLPDPAHVANCGSFFRNPIIPAPQAAELLRRYPDMPHWPVPGGGVKLAAGWLIDRAGFRGVADPETGMGTWPAQALVVVNHRASSTADLLRFKQKVQDEVRRRFGVTLEQEPELLP
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 39241 Sequence Length: 361 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q8NTB0
MDSSLAQEIAAIDGVELDSEVTFADLTTLRIGGKPRSAVRCQTTEALVSAIKLLDDASLPLLIVGGGSNLVVADGDLDVIAVIIETDDVSINLTDGLLTADAGAVWDDVVHLSVDAGLGGIECLSGIPGSAGATPVQNVGAYGTEVSDVLTRVQLLDRTTHQVSWVDASELDLSYRYSNLKFTNRAVVLAIELQLLTDGLSAPLRFGELGRRLAISEAEPHPRRPVRMVRDAVLELRRAKGMVVEHTDHDTWSAGSFFTNPIVDPALADAVFEKVGEPTMPRFPAGDGKEKLSAAWLIERAGFKKGHPGAGAKASLSTKHTLALTNRGDARASDLVALAKEIRDGVLETFGVTLVPEPVWIGISIDD
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 38886 Sequence Length: 367 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q67Q47
MSPMAERLRSIIRDPGRIRRAEPLKRHTSVRIGGPADYLVEVADRHELSRLLRLAGEEALPVYILGSGSNLVVSDEGVRGLVLRLTGEFARIAVDGSTVRVGGGCSLPKLAHQASRRGLGGLEFACAIPGTVGAGLVMNAGAHGGDMAQVVAEATVIWGDGRMERLCPGEIGFAYRSTRLQGTSAIVAEVVMALRPADRAALEGAMRQHLNRRRATQPLQYPNAGSVFKNPPGDYAGRLIEQAGLKGERVGDAQVSEKHANFIVNLGQATARDVLTLMDRVRSTVERRFGVRLEAEVKIWGHNPWFPP
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 33219 Sequence Length: 308 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q6FAZ1
MIHIQHQVQLKPFNTLNLDVVASHYIKVQSVNELIEALDYAEQQQLNALILSGGSNMLLPQSLDALVLHIDIQGLEMIDEDSESVKIKVGGGQIWHDFVLMTTQKGWYGLQNLALIPGLVGASPVQNIGAYGVEVGEFIELVHVYDRSEKSVKTISCADCKFAYRHSIFKDEPYRYIITHVTFKLFKTPNLKLSYGDLLKAVGNEQTPENLQKQVIQIRESKLPNPKEYPNVGSFFKNPVISRQDFNQLLTEFPLIPHYPQPHDRVKIAAGWLIDQAGWKGKRLGAVGMFEKQALVLVNYANATLIDVQHTYRHVQSDIQQKFKLRLEPEPVLFGSNGLILSHME
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 39023 Sequence Length: 345 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
A9KSS3
MNNVILQELKNIVSTERVTCNEPLSKHTSFKIGGPADYFVITKKIEETAAVIQCCNQHNLPLLMIGKGSNLLISDAGIRGVVLKQEDNTEGFFVTQCEEGYLVTGGAGMNLSAFAMKIANESLTGFEFAAGIPGSLGGAVYMNAGAYGGEIKDCIKSARVLTKEGQILSLNREELELSYRSSIIQKKGYYVIDATFLLQKGNQEDILRKIEELNQARKDKQPLEYPSAGSTFKRPEGYFAGKLIMDAGLRGYRVGGAMVSEKHCGFVINTGDATAKDVLQLIDDVRRIVKEKFGVTLEPEVRLIGEKVNP
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 33882 Sequence Length: 310 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q5ZSA6
MSITGMDSSHVTESQGTLLFNEPLAEYTTWRVGGPAARLYKPANIDDLALFLSRLPFDEPLLWLGLGSNSLIRDGGFSGTVILTQGCLKEMTLLSDNCIRVEAGVSCASMARFSARNNLSGGEFWAGIPGTMGGALRMNAGCHGGETWQSVIEVQTINRRGEIRTRKPEEFEVAYRHVAGLGDEWFISAKLQLSPGNKETSLQLIKDLLAHRAKTQPTNEYNCGSVFRNPPGDFAARLIESCGLKGVSIGGAVVSEKHANFIINHQGTATAANIEALIHLVQTKVREQTSIELIREVHIIGDANVQTR
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 33449 Sequence Length: 308 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q6AH30
MTDPPALSALTTMRVGGTPERLLEPADRDALVATAREVWSTGDEWLLLGGGSNTIAADDGFEGTVLRIVTRGVERLAAEKGRIRLRVQAGEPWDALVALTVRNGWAGIEALSGIPGSTGAAPVQNIGAYGQEIESALIGVEFLDYLTGEVYTLARAELGLGYRTSALKRGMAGVVLSVDLELADHSVPGGVGASLSAPIAYAQLADALAVPLGSRVSVDELRRAVLALRASKGMVLDPADPDSVSAGSFFTNPIVSENVARALPSDAPRWSLGPPEPDTILSLGPEGVHPLDVPPFAAGPYEAKLSAAWLIENAGIRSGFALPGSGAAISSKHTLAIVNRGAATAADVAQLASFVRGRVQADFGVVLHPEPVLVGLTL
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 39010 Sequence Length: 378 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q8EZC5
MSPVLSESQLRDFKHTLESSKIPFRSEVRLGILSSFKIGGVCPVIVEPEISSQVSEILHIFSKFDIPWKILGGGSNLLISDHPDNFVTLRLSGKFKEFVSLGDGKFKIGAATNTTPTFRQISQLGYTGAEFLSTIPGWTGGAVIQNAGCYGGELFDLIESVEFLRNGEMFVRKPSEIKYGYRFTEFLNQKDSIILGIEILLKEGNLEEIESSLKDKRDRRNSSQPENKKSAGSVFKNPKVFREDGKEIKAWELLDQAGLRGQIKGGAQISPEHCNFIVNLGTATASDVHYLIDLVVDRVYQTSGILLNREIEFFGDIP
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 35356 Sequence Length: 318 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q03VW0
MQLENIEILENHSLAPYAYTQAGGLVDYLAIPKSIHELKVLVNWAKELGMPVQVFGRLSNLIVRNGGLRGLSILLHDLRDVVVDQNKIVASAGADLIWVTEQAFEHGLSGLEWGAGIPGSVGGAVFMNAGAYGGQVDMVVSSVTALMPDGTLQNFEKKALEFGYRKSVFQSNGGIIISATFELQPDSCTAIRTRMDENNFKRANKQPLNYPSNGSVFKRPEGYFAGKLIMDSKLQGVRRGGVEVSKKHAGFMVNIAHGTGNDYEDLIHYVQKTVYEKFGVHLETEVRIMGER
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 32031 Sequence Length: 292 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q2LR56
MRIPVLHDFFIKEQLKSCVSGAVLFDEPLDRYTSMGVGGPADALVVPQSMEELVQLVRFLRKENIPFLTLGNGTNLIVRDGGCRGVVVALRGLQKLSWASDPEGKIRVQAEAGVPLASIVQLCIKESLAGLEFCTGIPGSVGGAVRMNAGAFGREMKDVVTAITVLNEHLELETLSRRELSFEYRRLNLSDEAVIVCAEFALCPGERESISAEISEILALRKSKHPLNFRNAGSIFKNPRNLPAGQLIEETGLKGTRRGDAMISEKHGNFIVNLGHARAADVVDLIEEIKGRVENCRAIQLEAEVHIVGEDG
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 33965 Sequence Length: 312 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q3A2G8
MHVLAARLGEILHSPVQLGEPLSRHTSWRIGGPAEIFLSPCDTKELVASLELLAQVGMPWIALGAGTNVLVRDGGFRGAVIHTGGLQDMAFDADGRARVGGGVPVMRLIRHCVERGLAGLEDLAGLPATIGGAVVMNAGAGKQDLAGVLDGAFLAGPSGVEYWPADRLELGYRTSAVPPGRIVTAASLRFRKASPEVLETYVRQRVQQRRKAQGVGKPNAGSVFKNPPGQQAWRLIDSCELRGFAVGGAQVSEKHANFIVNRGGARAEDVLRLIAEIQKKVEKRTGIVLEPEVKVVGQA
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 31691 Sequence Length: 299 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
P95837
MTGAVSLLETLQQAVPLAGFTSFRVGGLAQFYDEPASVEAIATAWQWARLADFPVTFLGAGSNLLISDRGLPGLVLNLRRLQGATFDLATGCVEVAAGEPIPRLAWAAARQGWSGLEWAVGIPGTLGGAVVMNAGAQGGCMADILQSVQVITDQGLETWSREQLQYDYRHSVLQTGHACVVSAQLQLQPGFERSQVLTTTSTNFRQRKRTQPYHLPNCGSVFRNPEPQKAGQLIEACGLKGYQIGDAQVSELHANFILNCGAARAQDILSLIRHVQGTVGDHFGVNLHPEVKLLGEFQDVI
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 32347 Sequence Length: 301 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
A0LNZ0
MIDNKRGSSYLNSLPEGLSAEECDRYSAVVSLCWNVLGELQDVEFKWHEPLAYHTTFRVGGPAACLARPRSESALLALLERVRENSVPYVVLGGGSNVLVTDGPIPALVIQLIHVAAGLAFNKGRSSSRPLVVVGAGVPISRLLRFCVRNELGGLECLVGIPGSVGGAVVMNAGTAEGTIAEALEWLDALDGAGQRQLVFKADLPAGYRSMGLPEAWLILGGAFRLHVSSGRSLKREMRSLMVRRKATQPLGRPSAGCVFKNPVEAPAGALIERAGLKGFRMGNAQVSDKHANWIINLGSARARDILALISLVENEVFGKFGVRLEREIRILSPEKNSLNQMLNS
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 37041 Sequence Length: 345 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98
Q0AY75
MYSEIFDFLPPERIKINEPMKEHSSFKIGGPVDLMVLPESIEEIQRITHYCRKKDIPCFVFGLGSNILVRDKGIRGVAIKVGNNLKNISICNDTIFAEAGVRLAELSQAAADYSLSGLEFAEGIPGSLGGAVVMNAGAYGGEMKDVLKEVRAITPDGNLSSFKPEEMKLRYRGSIFQEEELIVVSALMQLHKERAEDIRARMQDFAKRRREKQPLEYPSAGSTFRRPAGFFVGPMIEEMGLKGFKVGGAEVSRKHAGFIINSGNATANEVLELIAIVKAKAKEHYGIELETEVKVVGEE
Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine Sequence Mass (Da): 33010 Sequence Length: 299 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cytoplasm EC: 1.3.1.98