ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
O06473
MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAIAAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGSSSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLAGGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTMAVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTVRSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERSIASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGIKAGH
Function: Acts to efflux copper or a copper complex. It is possible that YfmO could contribute to copper resistance. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 41451 Sequence Length: 396 Subcellular Location: Cell membrane
O43033
MGILKKTIFIGGIYGLGVYIGAVAWRLRKDVLNYESRQKSDLLIPNSNSISIYNQIADKYSRKITREEIFSGIYFLRYFLLRNAKGDVLEVGSGPGTNFPFYKWKKINTLTLVEPAEKMREIADARAKKKVPPNVLYRQFADLRQLPPNQSYDTIIQTFCICSQEKAVEQLNNYRSLLRSDGRILLIEHGKGKYKFLNRILNAYAESHYESWGCVWNRDIEQLLEDSELTIDSCKRFNFGTTYVIEAH
Function: Probable methyltransferase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 28743 Sequence Length: 248 Subcellular Location: Mitochondrion inner membrane EC: 2.1.1.-
O43022
MVIEKRESFIEVVINSLLNDNPAQAKFDKYSILVSLGFSSLLSVILLCIFTLLRTKFNTYDRCIPPMKKSLWGWIEPLWSIKVEDCLYNMGADAVISLLFSRFCRDVFLILAAICCTILIPINIVATNKTLANSDSQNAYAKLSIQNVTGNWTWAHVVICYVFNVLVLFLLARYYQIVMRIRQRYYRSPTYQQSMSSRSLLIMDIPTTMRSNNGLSILASRLKSSEAPMHVHICHAIKNLPKILKKHDNAVRSLEAVLAKFFKNPKKLPDDRPVRRVKQGLLTSEKVDAIDYYSAKIENYGLRVDAARESLYENEFEHYGFITYKSSYIAHDTARHNSRVAGASVSMAPEPSDFLWDNLSLAWSTRLFNRMIGNILFIILIIAWIIETALVAIFISNLYHLGSVWPWLQQQLTSRSGFWSIVQGILSPAVAGFTFMILEIIMRRISYWQGSFTKSSRERGVLNKLHIIFTLDNFIIYTLMAVFWRLGVIIAYKTKEEGNFAEGMSAFATFDTVGLSVSSFVQFSTFWIMFIAHSTCSFFVEIAQPITLTIRLIKTKFFSPTPRDLLEWTAPTKYVYSQVLNKLIYFFTIAICYACINPLVLLFASVLFCVNYLTQKYILMYVSNSSTESGGGYWRPVVNRILLGLELANIILFLCLWVQGGRVRAYCIIPNFSFAIAFKIWCMFALDPKSHYMIEDPYMKVVEPLENEISESEMCFGHPSTYAPLLVPMVRSDARALLPLFYSGRTETHNKFDFATDSDDASEKHLRGEEEPLENVDFVDIDNVDTAKEVHDQQQVQQLKKNLSRSYTRSRGVSLRARLNEEELPLTESITQDSQISIPETLESQSTEITPINVSEHYDKYYHIF
Function: Acts as an osmosensitive calcium-permeable cation channel. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 99207 Sequence Length: 865 Subcellular Location: Cell membrane
P45470
MSKKIAVLITDEFEDSEFTSPADEFRKAGHEVITIEKQAGKTVKGKKGEASVTIDKSIDEVTPAEFDALLLPGGHSPDYLRGDNRFVTFTRDFVNSGKPVFAICHGPQLLISADVIRGRKLTAVKPIIIDVKNAGAEFYDQEVVVDKDQLVTSRTPDDLPAFNREALRLLGA
Function: Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals . Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage . Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair . In vitro, prevents acrylamide formation in asparagine/glyoxal and asparagine/sugar mixtures at 55 degrees Celsius, likely by degrading asparagine/glyoxal Maillard adducts formed at high temperatures . Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity . Is a general stress protein; is required for the protection of bacterial cells against many environmental stresses, including oxidative, thermal, osmotic, UV, and pH stresses . And plays an important role in protection against electrophile/carbonyl stress . Catalytic Activity: H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate Sequence Mass (Da): 18858 Sequence Length: 172 Subcellular Location: Cytoplasm EC: 3.1.2.-
G2TRT0
MELEAYIQSLGLGIESYSQSATQFHDEANQSFNIPISTIIKLKEACRELETSKVVAKSLNWSHLLRVISLLWEKDVSLELMKLLANCLRQVPSISVQIVHNESLKQLTTSVFEVRAPKVLSLISTFNDDLERRVVFMRFLFILLSTQTDDICLDMRQVRTQLIQMLKKMWTLNSSPSNNSQDNEMVLTEILRLLFPISKRSYLKEEDEQKILLLVIEIWASSLNNNPNSPLRWHATNALLSFNLQLLSLDQAIYVSEIACQTLQSILISREVEYLEKGLNLCFDIAAKYQNTLPPILAILLSLLSFFNIKQNLSMLLFPTNDDRKQSLQKGKSFRCLLLRLLTIPIVEPIGTYYASLLNELCDGDSQQIARIFGAGYAMGISQHSETMPFPSPLSKAASPVFQKNSRGQENTEENNLAIDPITGSMCTNRNKSQRLELSQEEKEREAERLFYLFQRLEKNSTIQVTNPIQQAVNSGFIDVVFCLIFQMSSESFIYHCYHSFVGPIHILLLMFSTFKFHEILHFIKISKAS
Function: Probable guanine nucleotide exchange factor (GEF). Location Topology: Single-pass membrane protein Sequence Mass (Da): 60627 Sequence Length: 530 Subcellular Location: Membrane
O60159
MSSQKRADSSSSFDQAERRSLDENERKKKYFFNREGSGIDNFETDDRVNEIINEQNEENVIDQSRWSKLWRIWNVGYSWFILSIIGTTVGFAAYMLDIVTSWLSDIRRGYCTSHWYYNEKFCCWYSETMGSSCTAWKPWTYKFSLNYLIYTAFALLFVLCAAIMVRDVAPLAAGSGISEIKCIISGFLRDSFLSFRVMLVKCVGLPLAIASGLSVGKEGPSVHLATTIGHNISKIFKYAREGSIRYRDICVASAASGVAVAFGSPIGGVLFGIEEMSGGYDPKMIVYSFFCCLSAVGVLHMLNPFRTGQVVLFEVRYSGSWHFFELLFFCFLGIFGGLYGEFVMRLFFLIQKLRKKYLSRWGVLDAAFVTVITSLVSFLNPWLRLDMTLGMELLFQECKSSSSPELINLCDPSLRTKNTILLLIATFARTIFVTFSYGAKVPAGIFVPSMAVGASFGYMIGLIAEMIYQRFPNSVLFLACHGSESCITPGTYALLGAAASLSGIMHLTVTIVVIMFELTGALNFILPTVLVVALANSIGNMLGKTGIADRSIEINGLPLLEPEKSINSSNTINIPITEVMASNLITIPSIGFTWRKLLGMMEGYDFSGYPVVLDSRSNYLIGYLKKSSLKSSFEAAKLEPSFTFDQQLCFGKVDSVGDSKSSKFGESDRIDLSAYMDVNPISVLHTQSIANVAVLFEVLSPSVIFIEKDGNLVGLISKKDLLLASKYYQEDNDLVNPANRHRAVSTERINDSYENIELKPLKLNIE
Function: Anion/proton exchange transporter involved in iron and copper cation homeostasis. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 85162 Sequence Length: 766 Subcellular Location: Vacuole membrane
Q11S04
MDKNQIIGISLISVLMLGYFGFMSTQTPETPVTTPPAITQPVQSDTVLLKSAATDTALKAQNQREYGDFAAAMVGEAKEYKLENKDVVVTLSTKGGTIKSVLLKNYFTWDKKQLFLFKQENNQLSLILNTNKKPVDLYSLYYAGVESKAGDKQVVTFKTDAGNGKTIEHTYTLGAAGFTVDYNLKAAGFGGELPNLPLTLDWREQVERIEYDSEQARVKSTVNYMAAEDGFDYLSEASKDRETETLSNVYWVSLKQKFFNSGFYIREGGTIPSATVTAYPMYSTLPNAPVNSEKFIKALEAQVQLPLEAVISGKAAYAFYFGPNDFKICKAVPAENYQKNVNLGWPLVSWINRFVVIPVFDGLKGVFSSFGLIIVILVLLIKLVLLPLSYKSFVSMAKMKALKPELDELKAKHGDDQQAIQMEQMQVYKQFGINPLSGCIPVLLQMPILLAMFNFFPNAIDLRGESLWWATDLSSYDEFAKLPFTIPFYGSHVSMFTLLMTISTLAYTWVNNQVSTVTGPMKYMSYAMPVVFLFVLNSFPAGLSFYYFVSNLVTIAQQLIIRRFVDEGQLRLQLEAKRDKNLSGDTTGGAPKKNRFMARMEEAMKQREQEQQFKKNIKKK
Function: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 69671 Sequence Length: 620 Subcellular Location: Cell inner membrane
Q9RSH5
MVAGRKAFALQAGDALSPDKPAEAQPAQVKTDLAANRQDAVFRYAQNGVQVTKTITLHPRNFKVDVRTEVRNGPAQVNMLFPGLGKADNPRVQAVPVGGQPASVQGSGTLSVQNIQYAALQENPSQIAHALIVRPQQGTKVDVQLTGGPQGLVTATLPATSSLEVYGGKNELIHLYQSGYTELPGLFQPNFFGQISLLIVKLMEALYKVIGNWGLVIMALTILLRLVMWPLMQAQGRTTARMQLVQPLQKEIQEKYKGKTDPESQRAMQMEMAQLMRDYQVNPAGCFSTLLPFPVLIALWATIRNFEFDSGFLWLPDLATPDPFYILAVIYLFVNLGQLYVSTRKTPEMFRQQAMIYLVFLYFALTFPSGVTLYIILSTIIGIVQQIIINKQVEHETASLGQTVQKVAPGTRPASKTTVTKTIDAPKK
Function: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 47173 Sequence Length: 428 Subcellular Location: Cell membrane
B8DP11
MESKRAIIAIALSFVVLVGWSYLADHMGWNGQPAPQAQQEETAPSASQAAPQSASQAAAPAPRAETPVFLPSAGREVTVVTPLYKAVLHSGGGVLKHFSLTRYRTAITAGAPAVDMVDTASTVMSPLGLLINGQPSWNTGQWSFDGGDLSLGAGQSGVLTFTGEVDGVRVVRELTFSADTYLISEKVRLAPLADARTVRLGFTVGTGNLSPNGGQYDHTRVAWLHDGSFSEKTSASDLEKGVLETGALSWGAVMSNYFLVAAAPVDTTGVTLKGKLQEGVYRVAMERGDVSIPAGGETTVACNYWFGPKDRGLLKEAPNQLAEAINLGWFSIIARPLVDMLEFFHKYVGNYGVAIILLTVVIKLVFWPLSHKSYKSMEQMKKLQPMLQKLREKHGDDREKMNEEMMRLYKTYKVNPAGGCLPMLVQIPVFFGLYQALLNAIELRHASFITHLPFTDMVWLADLSAKDPYYITPIVMGATMLLQQKLTPAPGDPTQAKIMMFMPVVFTFMFLSFPSGLVVYWLCNNVLSIAQQWWMLRKA
Function: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 58923 Sequence Length: 539 Subcellular Location: Cell inner membrane
Q8ZKY4
MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQTQQTTQTTTTAAGSAADQGVPASGQGKMITVKTDVLDLTINTRGGDVEQALLPAYPKELGSNEPFQLLETTPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKEAFVLADGQNELQVPMTYTDAAGNTFTKTFVFKRGDYAVNVNYSVQNAGEKPLEVSTFGQLKQSVNLPPHRDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNVSSKGGWVAMLQQYFATAWIPRNDGTNNFYTANLGNGIVAIGYKAQPVLVQPGQTGAMTSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLMGSIELRHAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
Function: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 61634 Sequence Length: 548 Subcellular Location: Cell inner membrane
Q8EKT6
MESQRNILLIGLLFVSFLLWQQWQADKAPKPVATESSVVANATTNHSADVPEADTGVPAAVAATQNLITVKTDQLDVQINPVGGDIVYAALVSHKLEQGKDQPFVLLEQTKDFTYIAQSGLIGRDGIDSSAKGRAIFAASKTEFTLADGQDSLEVPLTYVAENGVTYTKVFVFHRGKFNVNIDYKINNTSAAPLQVQMYGQIKQTIKPSESSMMMPTYRGAAFSTASVRYEKYNFEDMGKNNLNQPTIGGWAAMLQHYFVSAWIPPATDSNTIFSSVSAGGLANIGFRGAVYDVAPGATQEISSQFYVGPKDQKALSALSDTLNLVVDYGFLWWLAVPIHWLLMFYQSFVGNWGVAIILITLTVRGLLFPLTKAQYTSMAKMRNLQPKLQDLKERFGDDRQKMGQAMMELYKKEKVNPMGGCLPILLQMPIFIALYWVLLESFELRHAPFMLWIHDLSVQDPYYILPLLMGVSMFIMQKMQPIAPTMDPMQVKMMQWMPVIFTVFFLWFPSGLVLYWLVGNIVAIIQQKIIYAGLEKKGLN
Function: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60451 Sequence Length: 541 Subcellular Location: Cell inner membrane
A8FP42
MESQRNILLIGLLFVSFLLWQQWQTDQAPQPVAMESSSTIPSSSTSDSHSSDVPDADSALPAAVVASKELITVNTDQLIIKINPIGGDIVYSALVEHKLELDKDEPFVLLEQTKDINYIAQSGLIGRNGIDSSSKGRAHFDSASREYTLASGQDTLEVPLTFVADNGATYTKMFVFHRGQFKVDVDYVIDNSTDQQLQVQMYGQIKHSIKQSESSMMMPTYRGAAFSTANTRYEKYSFDDMADKNLDEKTLGGWAAMLQHYFVSAWVPPANDQNIIFSSISAGGQANIGFRGAVYDVAPGATQTINSEFYVGPKNQEALSAISESLNLVVDYGFLWWLAVPIYKLLMFFQSLVTNWGLAIILITLTVRGMLYPLTKAQYTSMAKMRNLQPKLAEMKERFGDDRQKMGQAMMELYKKEKVNPMGGCLPILLQMPIFIALYWVLLESVELRHAPFMLWITDLSVQDPYYVMPILMGISMFVMQKMQPMAPTMDPMQQKMMQWMPVVFTVFFLWFPAGLVLYWLVGNLVAITQQKIIYAGLAKKGLK
Function: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 61116 Sequence Length: 544 Subcellular Location: Cell inner membrane
B3PIU2
MVWAGVKLLHGYRYLLSPWIGNQCRFYPSCSHYAEEALKTHGFLAGIYLTARRLIKCHPWHPGGIDPVPEHEATCCSHTHPTHGKH
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 9788 Sequence Length: 86 Subcellular Location: Cell inner membrane
A4WNL6
MSPLAQIFALPVRAYRLLLSPWVGHGCRYQPTCSVYALEALERHGALKGGWLAARRILRCHPWGGSGYDPVPGADPEHDRRPRG
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 9333 Sequence Length: 84 Subcellular Location: Cell inner membrane
A9WDP2
MLRWLLLKLIRFYQVAISPWTPPSCIYTPTCSHYGYEAIKKYGALRGGWMTVKRIARCHPFARGGYDPVP
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 8104 Sequence Length: 70 Subcellular Location: Cell membrane
Q3B109
MVIWKVVNKAPLALIKFYRAILSPMFPPSCRFYPTCSAYALEAFETHNFFKASWLSLWRILRCNPFSKGGFDPVPPHDGVPGKKED
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 9849 Sequence Length: 86 Subcellular Location: Cell inner membrane
Q9Z7W2
MSFKRFLQQIPVRICLLIIYLYQWLISPLLGSCCRFFPSCSHYAEQALKSHGFLMGCWLSIKRIGKCGPWHPGGIDMVPKTALQEVLEPYQEIDGGDSSHFSE
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 11751 Sequence Length: 103 Subcellular Location: Cell inner membrane
B0B846
MQTSRISSFFRGLVHLYRWAISPFLGAPCRFFPTCSEYALVALKKHPLRKSLFLIAKRLLKCGPWCIGGIDLVPRTSVEEYLSSPTPLAESPDDRTVPHTQETS
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 11737 Sequence Length: 104 Subcellular Location: Cell inner membrane
Q8KGG3
MNIVPILLIRFYQSFISPLLGPSCKYHPTCSNYAIEAFRQHNFFYASWLTVWRVLRCNPFSKGGYDPVPPKSVKSAGNSKDSK
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 9487 Sequence Length: 83 Subcellular Location: Cell inner membrane
Q02LJ2
MKFLLIGLIRFYQYAISPLIGPRCRFYPSCSHYTLEAIRVHGALRGGYLGARRLLRCHPWHPGGYDPVPERQEQACACHRTAKPGE
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 9825 Sequence Length: 86 Subcellular Location: Cell inner membrane
Q3K427
MRKLALVPIRFYRYAISPLMASHCRFYPSCSCYAYEAIENHGLLRGGWLTFRRLGRCHPWNPGGYDPVPPIPTSRSSSMAE
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 9278 Sequence Length: 81 Subcellular Location: Cell inner membrane
P0A179
MRKLALVPIQFYRYAISPLMANHCRFFPSCSCYAYEAIENHGIWRGGWLAVRRLGRCHPWNDGGYDPVPPAPSSRTSSIAE
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 9214 Sequence Length: 81 Subcellular Location: Cell inner membrane
Q3IK54
MRLLKPLVALPTYCLVLFIRGYQKWISPLLGPHCRFNPTCSSYAIQAINLHGSVKGSWLAVKRILKCHPLHSGGNDPVPEKLTHINHQHEK
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 10289 Sequence Length: 91 Subcellular Location: Cell inner membrane
Q4FPR6
MYFFIKTINKYLYKLIYSFIVFYQKIISPILPARCRYYPTCSNYGKQALAWYGVWNGSLLLLKRIGRCHPLGGHGIDFVPLPLASYHYQHVSLIMSACMKAQGLYVYRDNNGYVARLNHMMKLT
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 14485 Sequence Length: 124 Subcellular Location: Cell inner membrane
Q98LQ9
MHDPHGHAHTVRPPGRGRNWPGPWRKTPGRLLGTSFVRLYQLTLSGFVGNSCRHLPTCSEYAHEAIARHGLWAGGWMGFFRVLRCGPFGTHGIDLVPEVLADRYVWFMPWRYWRIGRKRAETRA
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 14304 Sequence Length: 124 Subcellular Location: Cell inner membrane
Q92QB2
MCPQPHADHAITRGDTGAAGGRNWSGPFRKTPGRLVGMTLIRAYQLTLSSFIGNSCRHLPTCSEYGFEAIARYGLWAGGWLTLFRVVRCGPGGTHGFDPVPDSLAPRQRWYTPWRYWQPRRKDA
Function: Could be involved in insertion of integral membrane proteins into the membrane. Location Topology: Peripheral membrane protein Sequence Mass (Da): 13920 Sequence Length: 124 Subcellular Location: Cell inner membrane
Q9UTC5
MALQVDAPDVSSYDELYNRAVELLKHQQRVLIGLAGGPGSGKSTLCAILAKAWNERFGSEIVKIIPMDGFHYSLEELDRFDNPEKARALRGAEWTFDADLFYSLVRLMKKITDRELYAPSFDHAIGDPVVDDICVEPKNRILIFEGNYLLLNKPPWSDACKLYDIKAYLPVEHSVARARVAHRHLVSGLCATEEEAIERTDRNDMINLTFVEKNMVTPDIVLQQLRLKTVKTSSL
Catalytic Activity: ATP + uridine = ADP + H(+) + UMP Sequence Mass (Da): 26620 Sequence Length: 235 Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Subcellular Location: Cytoplasm EC: 2.7.1.48
P32136
MSDHNPLTLKLNLREKIAYGMGDVGSNLMLCIGTLYLLKFYTDELGMPAYYGGIIFLVAKFFTAFTDMLTGFLLDSRKNIGPKGKFRPFILYAAVPAALIATLQFIATTFCLPVKTTIATALFMMFGLSYSLMNCSYGAMIPAITKNPNERAQLAAYRQGGATIGLLICTVAFIPLQSLFSDSTVGYACAALMFSIGGFIFMMLCYRGVKEHYVDTTPTGHKASILKSFCAIFRNPPLLVLCIANLCTLAAFNIKLAIQVYYTQYVLNDINLLSWMGFFSMGCILIGVLLVPLTVKCFGKKQVYLAGMVLWAVGDILNYFWGSNSFTFVMFSCVAFFGTAFVNSLNWALVPDTVDYGEWKTGIRAEGSVYTGYTFFRKISAALAGFLPGIMLTQIGYVPNIAQSDATLQGLRQLIFIWPCALAIIAALTMGFFYTLNEKRFALIIEEINQRKNKEMATEEKTASVTL
Function: Could be involved in sulfoquinovose import. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 51574 Sequence Length: 467 Subcellular Location: Cell inner membrane
P0A8Y3
MLYIFDLGNVIVDIDFNRVLGAWSDLTRIPLASLKKSFHMGEAFHQHERGEISDEAFAEALCHEMALPLSYEQFSHGWQAVFVALRPEVIAIMHKLREQGHRVVVLSNTNRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSPSDTVFFDDNADNIEGANQLGITSILVKDKTTIPDYFAKVLC
Cofactor: Magnesium. Can also use other divalent metal cations such as manganese, cobalt or zinc. Function: Catalyzes the dephosphorylation of alpha-D-glucose 1-phosphate (Glc1P) and, to a lesser extent, of other sugar phosphates . Has no activity with the beta form of Glc1P. In addition, YihX has significant phosphatase activity against pyridoxal phosphate (PLP) and low beta-phosphoglucomutase activity . Catalytic Activity: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate Sequence Mass (Da): 22732 Sequence Length: 199 EC: 3.1.3.10
P70947
METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCISTGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISESYNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEEDVPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAFGDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL
Function: Catalyzes the dephosphorylation of the riboflavin precursor 5-amino-6-(5-phospho-D-ribitylamino)uracil and of flavin mononucleotide (FMN) in vitro . Catalytic Activity: 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate Sequence Mass (Da): 30633 Sequence Length: 270 Pathway: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 4/4. EC: 3.1.3.104
O31623
MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDADGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIAGLAGIIETLVSKWLQE
Function: Involved in sporulation. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13036 Sequence Length: 118 Subcellular Location: Cell membrane
O31626
MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLLRLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSPAVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSGKTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGTFHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGFWKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLLEQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFILDFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYPYDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQSFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKALAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLEKGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTVYVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTANRSRFLYPLLQKARQPLHH
Function: May be involved in the generation of recombinogenic substrates for the subsequent action of RecA. Catalytic Activity: Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction. Sequence Mass (Da): 86976 Sequence Length: 759 Subcellular Location: Cytoplasm EC: 5.6.2.4
O31633
MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYTVEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDKAHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNVKINGVWEDHQVLAILNPDDEQ
Function: Acetylates the N-terminal alanine of ribosomal protein S5. Catalytic Activity: acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5] Sequence Mass (Da): 20925 Sequence Length: 181 Subcellular Location: Cytoplasm EC: 2.3.1.267
P39358
MSVRNIFADESHDIYTVRTHADGPDGELPLTAEMLINRPSGDLFGMTMNAGMGWSPDELDRDGILLLSTLGGLRGADGKPVALALHQGHYELDIQMKAAAEVIKANHALPYAVYVSDPCDGRTQGTTGMFDSLPYRNDASMVMRRLIRSLPDAKAVIGVASCDKGLPATMMALAAQHNIATVLVPGGATLPAKDGEDNGKVQTIGARFANGELSLQDARRAGCKACASSGGGCQFLGTAGTSQVVAEGLGLAIPHSALAPSGEPVWREIARASARAALNLSQKGITTREILTDKAIENAMTVHAAFGGSTNLLLHIPAIAHQAGCHIPTVDDWIRINKRVPRLVSVLPNGPVYHPTVNAFMAGGVPEVMLHLRSLGLLHEDVMTVTGSTLKENLDWWEHSERRQRFKQLLLDQEQINADEVIMSPQQAKARGLTSTITFPVGNIAPEGSVIKSTAIDPSMIDEQGIYYHKGVAKVYLSEKSAIYDIKHDKIKAGDILVIIGVGPSGTGMEETYQVTSALKHLSYGKHVSLITDARFSGVSTGACIGHVGPEALAGGPIGKLRTGDLIEIKIDCRELHGEVNFLGTRSDEQLPSQEEATAILNARPSHQDLLPDPELPDDTRLWAMLQAVSGGTWTGCIYDVNKIGAALRDFMNKN
Function: Catalyzes the dehydration of D-xylonic acid to form 2-dehydro-3-deoxy-D-pentonate. Catalytic Activity: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O Sequence Mass (Da): 70017 Sequence Length: 655 EC: 4.2.1.82
P46992
MLQSIVLSVCMFMLHTVAASGPQSYQKLDFTNVGFTGSYVDVNKFKDITNNESCTCEVGDRVWFSGKNAPLADYLSVHFRGPLKLKQFAFYTSPGFTVNNSRSSSDWNRLAYYESSSKTADNVTFLNHGGEASPCLGNALSYASSNGTGSASEATVLADGTLISSDQEYIIYSNVSCPKSGYDKGCGVYRSGIPAYYGYGGTTKMFLFEFEMPTETEKNSSSIGYYDLPAIWLLNDHIARTSQYPTNANCSCWASGCGEYDIFEAMNGTEKNHLYSTFHTFQGIEDLGTGIQSYGYITRNTTGTMKGGVVFDSSGNVVSFISDATPFNGTVSADTVNDLLAAIPENETYSSQLMSISATAPSTTSKSNGVALTKMQNGVWYYILAIFTAFTQVVLI
PTM: Extensively N-glycosylated. Location Topology: Lipid-anchor Sequence Mass (Da): 42958 Sequence Length: 396 Subcellular Location: Cell membrane
O31711
MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGKSTIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKKNVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEPKLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNIVPASSGQRSVGE
Function: Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation-delaying protein). Location Topology: Peripheral membrane protein Sequence Mass (Da): 25272 Sequence Length: 230 Subcellular Location: Cell membrane EC: 7.6.2.-
O31712
MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQGGEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVASTSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKMAKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDFSNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIGSIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGGLVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIEALRYE
Function: Part of an unusual four-component transporter, which is required for protection against the killing factor SdpC (sporulation-delaying protein). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 42125 Sequence Length: 397 Subcellular Location: Cell membrane
O34572
MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGVLLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSVGISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDEVQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRNRTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS
Function: Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Probably responsible for the translocation of the substrate across the membrane (Probable). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 28042 Sequence Length: 254 Subcellular Location: Cell membrane
O34362
MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPSGCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQFCMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALACILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIERTIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKEPIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKSTLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLFGQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEPTFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPAQLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH
Function: Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Responsible for energy coupling to the transport system (Probable). Location Topology: Peripheral membrane protein Sequence Mass (Da): 61146 Sequence Length: 547 Subcellular Location: Cell membrane EC: 7.6.2.-
O34738
MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEPIYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAVFLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLAGLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL
Function: Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Probably responsible for the translocation of the substrate across the membrane (Probable). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21224 Sequence Length: 199 Subcellular Location: Cell membrane
O34903
MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAAEGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYVTKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPREFDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHTIRGVGYAIKG
Function: Probable member of the two-component regulatory system YkoH/YkoG. PTM: Phosphorylated by YkoH. Sequence Mass (Da): 26012 Sequence Length: 228 Subcellular Location: Cytoplasm
O34638
MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLADETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLSFHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAASAAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTFNEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIHSEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKESLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIPHLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQNGGGR
Function: Probable member of the two-component regulatory system YkoH/YkoG. Potentially phosphorylates YkoG. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 50651 Sequence Length: 454 Subcellular Location: Cell membrane EC: 2.7.13.3
Q07990
MKISQFGSLAFAPIVLLQLFIVQAQLLTDSNAQDLNTALGQKVQYTFLDTGNSNDQLLHLPSTTSSSIITGSLAAANFTGSSSSSSIPKVTSSVITSINYQSSNSTVVTQFTPLPSSSRNETKSSQTTNTISSSTSTGGVGSVKPCLYFVLMLETIAYLFS
PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 16950 Sequence Length: 161 Subcellular Location: Secreted
Q06235
MQHTLTRTASLPERSSSAHSAATALPALRRPPDSCETLVPLLCIFWFVFVSMSPLPPARANKSDNKGLISADRNNKATLLLTIPRCTSKSYTNDLSPLKMTLLSAGKHPRPFRQEHRC
Function: Overexpression confers resistance to the antimicrobial peptide MiAMP1. Location Topology: Single-pass membrane protein Sequence Mass (Da): 13055 Sequence Length: 118 Subcellular Location: Membrane
Q5UQP2
MNNSNTDNIIIINDSEPTYNLEDVINEIGDLLEDFDKIIDQYKQTIDQMVKKPKYVNLVLSGGSIRGISHIGVIKKLIDEELLDLSKMKAVAGVSAGAMLGLLIVLGFTIGEIWDFILNLDTKKIVDPDFMLILEKCGVERGRIIYDLIEDILTSKTDTKHINFKQLYEKTGIHFTVVGSCLTTKDVIYYDHINTPTFKVSVAVRISIGMPGFFTPIDIGGKKYIDGAVLNNYPMNLFAKELDKTIGILICNEHNTNYKYFEEYFMAIINLFMYNYFEKTCHQYADNTIYVKKAPENVFIFNFDLDNNTKMKLFEYGIEAAEEFIKNKFDNK
Function: Probable lipid hydrolase. Location Topology: Single-pass membrane protein Sequence Mass (Da): 37991 Sequence Length: 332 Subcellular Location: Membrane EC: 3.1.1.-
O07634
MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVKDTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVETIKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVLPEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND
Function: Probably contributes, directly or indirectly, to early events in germination. Location Topology: Lipid-anchor Sequence Mass (Da): 23384 Sequence Length: 209 Subcellular Location: Forespore inner membrane
Q9UM01
MVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFFPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSATRYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN
Function: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine . Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells . The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). Catalytic Activity: L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55991 Sequence Length: 511 Subcellular Location: Basolateral cell membrane
Q9Z1K8
MVNSTKYEVAAQHEADDGSALGDGASPVAEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSASFGLSLVIWAVGGIFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFANYMVQPLFPSCGAPYAAGRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGIVRLGQGATANFENSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMPIVTIIYLLTNVAYYSVLDIKEILASDAVAVTFADQIFGVFNWIIPVAVAFSCFGGLNASIVAASRLLFVGSREGHLPDAICMVHVERFTPVPSLLFNGVLSLVYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKDPDRPRPLKLSLFFPIIFCLCTIFLVAVPLYSDTINSLIGIGIALSGLPFYFFIIRVPEHKRPLFLRRIVASITRYLQILCMSVAAEMDLEDGELSKQDPKSK
Function: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine . Also mediates L-arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). Catalytic Activity: L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55677 Sequence Length: 510 Subcellular Location: Basolateral cell membrane
Q59I64
MQLKKEISLLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLVIWAIGGIFSVVGALCYAELGTTITKSGASYAYILESFGGFIAFIRLWTSLLIIEPTSQAVIAITFANYLVQPLFPTCEPPYSASRLIAAACICLLTFINSAYVKWGTRVQDVFTYAKVLALIVIIITGIVKLCQGFTINFEDSFQGSSRDPGGIALALYSALFSYSGWDTLNFVTEEIKNPERNLPLSIAISMPIVTIIYILTNVAYYAVLDMSAILASDAVAVTFADHTLGVMSWTIPIAVALSCYGGLNSSIIAASRLFFVGAREGHLPDALSMIHIERFTPVPALLFNCAMALIYLTVEDVFQLINYYSFSYWFFVGLSIAGQIYLRWKEPDRPRPLKLSLVYPIIFCLCVVFLVAVPLYSDTLNTLIGIAIALSGVPVYFLGIHLPESKRPPIITKLLSAITRFTQFTCFYVLTEMDTVD
Function: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). Catalytic Activity: L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 51234 Sequence Length: 468 Subcellular Location: Cell membrane
Q92536
MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD
Function: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis . Also exchanges L-arginine with L-lysine in a sodium-independent manner . The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 . Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells . May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). Catalytic Activity: L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56828 Sequence Length: 515 Subcellular Location: Cell membrane
Q28I80
MKETENQTVPLNSTSPGDTSHTSTSDSKDPQDTMQLKKEISLLNGVSLIVGNMIGSGIFVSPKGVLIYSASYGLSLILWSLGGIFSVIGALCYAELGTTIKKSGASYAYILEAFGDFVAFIRLWTSLLIIEPTSQAVIAITFANYLVQPVFPSCYPPYMASRLIAAACVCLITFINCAYVKWGTRVQDLFTYAKVIALIAIIITGIVKLSQGQTENFEDSFAGSSWDAGEISLGLYSALFSYSGWDTLNFVTEEIKNPERNLPLSIGISMPLVTIIYILTNVAYYTVLDFNAVVASEAVAVTFADMVYGVFSWTIPVAVALSCFGGLNSSILAASRLFFVGAREGHLPDMLCLIHQERFTPVPALLFNCVATLIYLAVKDVFQLINYYSFSYWFFVGLSIAGQIYLRIKKPELPRPVKLSLFYPIVFCLCTVFLVIVPLYSDTVNSLIGIGIALSGIPVYFMGIYLPESKRPPFISRVLAFLTRRTQMIFNCVLTEMDPIDEKKQNQTENRKVQ
Function: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1: 1 (By similarity). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). Catalytic Activity: L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56654 Sequence Length: 514 Subcellular Location: Cell membrane
F3YDF1
MFSTTTHSVPYLYLGNFSRKPHYYSVNRTKLHGSAGAARLSKSTSTSSRSHDLVLDLRNLLSRSSASIQGMVERAARLNGILDRRLVDDVLAKVTSMLPSMRDVRVTLEESATQIGRVQLQNYQFEVSLTGAAGSVPTGANVKVIPTITPGLLRPLFSQQQLNQIRGFKTDRSIEAEQKRNPTMTSRLKNALANSPQRLDGDTPLQAEKLRRLLAKSEEHGFNKAESLKIAFAEGYLAAANSEDSPKSGKTMKYLKTLQTIVVIVVFLGIFLSFFTTSNGSVFRSIQLGNQVEVDPEEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKILHDEIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAILNESQT
Cofactor: Binds 1 zinc ion per subunit. Function: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region . Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism . Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins . Required to control the accumulation of nonassembled respiratory chain subunits such as ND-30 . Location Topology: Single-pass membrane protein Sequence Mass (Da): 81081 Sequence Length: 740 Subcellular Location: Mitochondrion inner membrane EC: 3.4.24.-
Q96TA2
MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR
Cofactor: Binds 1 zinc ion per subunit. Function: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region . Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism . Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins . Required for normal, constitutive degradation of PRELID1 . Catalyzes the degradation of OMA1 in response to membrane depolarization . Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) . PTM: Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. Sequence Mass (Da): 86455 Sequence Length: 773 Subcellular Location: Mitochondrion inner membrane EC: 3.4.24.-
Q925S8
MFSLSSTVQPQVTVPLSHLINAFHSPKNISVSVNTSASPKQHRDTVAEHEAPSSEPVLNLRDLGLSELKIGQIDKLVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLQSICSDLQNFPVFIQSRGFKTLKSRTRRLQSTSERLAEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIEFPMHPYSRQTIIQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNEIRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR
Cofactor: Binds 1 zinc ion per subunit. Function: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure (By similarity). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (By similarity). Required for normal, constitutive degradation of PRELID1 (By similarity). Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity). PTM: Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. Sequence Mass (Da): 79867 Sequence Length: 715 Subcellular Location: Mitochondrion inner membrane EC: 3.4.24.-
P29911
MTADAAYQRGRALAEHLNPGMEVALRDRYGRWLPDAVAETVVGHGMGEVYAREGLDLKTRLLVTVGALAAMGGQTRPQLKVNVASALRAGASAREICEAIFQMHLYGGMPAAINALNAAIEVFEAEGTSP
Function: May have a role in the regulation of NDH-1 biosynthesis. Location Topology: Peripheral membrane protein Sequence Mass (Da): 13765 Sequence Length: 130 Subcellular Location: Cell membrane
P29912
MTDAFQKLFQQMLQSGQEMARAFNPALEHFDMRAMEKLVPTIPADMLEMWFGKTFNREGLDAKTRLLLTIGAITVQGALAEPQLRMTVRQALAAGATKREIAETIFQMSMFGGLPAMQKALEIAQSVYAEEDEE
Function: May have a role in the regulation of NDH-1 biosynthesis. Location Topology: Peripheral membrane protein Sequence Mass (Da): 15002 Sequence Length: 134 Subcellular Location: Cell membrane
Q12282
MLGLYLSSLFFAFFMAQVFATKYSITFTSDEYEEDETGQNEPGPLVFHLDKNSLPPALLNQMEFNPYLVLADLPEEPRAVDSQEHTDTVLASKSVIDFLLEDPLTIVEHKKFSQIESILHEIMEDSIQKKVGADEVFEEIPKPKIYAYEDILVTNMSIINNSEMPTSTATLTSTISYLSSTTSLALSTGVTSVEIFPTITPGNITTIGGYENSSSSLMPSMGILSFLFGLYLLLHP
PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 26157 Sequence Length: 236 Subcellular Location: Secreted
P15273
MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANIVLTQEDTAKLLQSTVKHNLNNYELRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSVLHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
Function: Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages. Catalytic Activity: H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Sequence Mass (Da): 50939 Sequence Length: 468 Subcellular Location: Secreted EC: 3.1.3.48
O68718
MIGPISQINISGGLSEKETSSLISNEELKNIITQLETDISDGSWFHKNYSRMDVEVMPALVIQANNKYPEMNLNLVTSPLDLSIEIKNVIENGVRSSRFIINMGEGGIHFSVIDYKHINGKTSLILFEPANFNSMGPAMLAIRTKTAIERYQLPDCHFSMVEMDIQRSSSECGIFSLALAKKLYIERDSLLKIHEDNIKGILSDGENPLPHDKLDPYLPVTFYKHTQGKKRLNEYLNTNPQGVGTVVNKKNETIVNRFDNNKSIVDGKELSVSVHKKRIAEYKTLLKV
Function: Serine/threonine-protein acetyltransferase translocated into infected cells, which inhibits the host immune response and induces cell death by mediating acetylation of target proteins . Inhibits the MAPK and NF-kappa-B signaling pathways by acetylating protein-kinases such as MAP2K1, MAP2K6, MAP3K7/TAK1 and I-kappa-B kinase (CHUK/IKKA and IKBKB) on serine and threonine residues critical for their activation by phosphorylation, thereby preventing protein-kinase activation . Promotes pyroptosis, a programmed cell death, in host cells by mediating acetylation of MAP3K7/TAK1: MAP3K7/TAK1 inactivation triggers activation of caspase-8 (CASP8), followed by CASP8-dependent cleavage of gasdermin-D (GSDMD) and induction of pyroptosis . Catalytic Activity: acetyl-CoA + L-threonyl-[protein] = CoA + O-acetyl-L-threonyl-[protein] Sequence Mass (Da): 32453 Sequence Length: 288 Subcellular Location: Secreted EC: 2.3.1.-
Q06616
MGIQEKTLGIRKERKLVVVPRERNHVRHASQRTRSKNYKNISKKRAQQHAFGFNIAKTLAKIQAFVWGSPADEEEESVVPLSKNSQDCVPLQWQAKFAQLRQQLHSTQKELQFVKEKCHLLQSVLDDANIDQRYLESRRDMKNIERDNLKPTENLPPSPVRAVNPLVTSSPIHMSPLQSRQRPVSSLQPPKGPNFYAKYPKLPQTNILRESPTEDSVPHAE
Function: Specialized component of the nuclear membrane that may be involved in the connection of the spindle pole body (SPB) to the nuclear envelope. Location Topology: Peripheral membrane protein Sequence Mass (Da): 25411 Sequence Length: 221 Subcellular Location: Nucleus membrane
Q08930
MDLSFTTKSVKINGQNHRILLQNENGPCALLALANILILSPDHTRFSNELIRLVNKGSQISLKELIEVLADIALQVTDKPSTDISELLSLLPRLHEGLNINPEFNGSFENTKEMSIFRLFNVDVVHGWVINSFINENIDEKLSHYSYESAQRILTQAADINCGISQDENSDEVLRDAMHLGLFLNESPTQLTAFGLLRLREKLLHNKFSILFRNDHFSTLFKYEDRLYTLVTDFGYKNCKDIVWQSLDSVDGSCDAFFAGNFSAAEVNGQQLSTDIERDFGTGNLLLEEIQQIENDKELAKQLQEQEQERVTKFEAKRKIHSHKKNSEIHAPVKKDKFKRRSSLLNAKASEKEKSECVVM
Function: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has endodeubiquitinase activity. Catalytic Activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Sequence Mass (Da): 41032 Sequence Length: 360 Subcellular Location: Cytoplasm EC: 3.4.19.12
O34634
MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSRLSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMAAEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15210 Sequence Length: 138 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q8AAP5
MSRIVAIDYGRKRTGIAVSDTLQLIANGLTTVPTHELLNFIGGYVAKEPVERIIIGLPKQMNNEASENMKNIEPFVRSLKKRFPELPVEYVDERFTSVLAHRTMLEAGLKKKDRQNKALVDEISATIILQTYLESKRF
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15688 Sequence Length: 138 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q2SPG9
MATVVGFDFGLKRFGAAVGQSVSMTASPLKEIPAQDGIPRWEAIEALLEEWKPALVIVGEPLNMDGSVSEMALRARKFARRLHGRYNLRVEMADERLTSSEAKSMVRERYGQRDFGRFAVDSIAAVFIVESWLEAHADNLDAFLHPPRKQGKSNDIID
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 17646 Sequence Length: 158 Subcellular Location: Cytoplasm EC: 3.1.-.-
B8D2B0
MRIMGLDYGDRRIGVAISDKLGMTAQGQEVIIRKTPEEDLEVIKGLIDKYEVEEIIVGMPKNMDGSLGPRAEKTRDFIDFLQKSLDTPVKVWDERLSTVEAERVLIEADVSRKKRKGVIDKVAASIILQGYLNYQNKLHG
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15816 Sequence Length: 140 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q7VGU1
MNHCILACDVGLKRIGLATLKQEIILPLPPIIRINRNQAAKELDNVLKERNIHILVVGMPSGGEAEHSDTQKRISHFISLLSFEGEICFVNEDYTSFNALQSLSYMKRQNRARAQKDGRIDSLSACEILQRYIQSQKS
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15623 Sequence Length: 138 Subcellular Location: Cytoplasm EC: 3.1.-.-
O25101
MILACDVGLKRIGIAALLNGVILPLEAILRHNRNQASRDLSDLLREKNIQVLVVGKPHESYADTNARIEHFIKLVDFKGEIVFINEDRSSIEAYENLEHLGKKNKRLAIKDGRLDSLSACRILERYCQKVLKNH
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15256 Sequence Length: 134 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q31EK3
MTKPIEGVVIGFDFGLKRIGVAIGQTITRTATPEAIVASKDGKPDWEHISRLFEEWKPSAIVVGLPMRLNGEEQALTQPARKFGQRLSGRYQRPVYYIEEQLSSIEAEQRKTKTDQPMDDHAAQIILENWLDAL
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15134 Sequence Length: 134 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q0BZU8
MAVVDLFDLPREGVLLGIDPGTATIGVAATDRIRMMASPVETILKKKLAPSLERLLHIYDERAAVGLIVGLPLNVDGSMGPRAQSVRTLVSSLLKVRDLPVTFQDERYSSAEAGDIMRAAGATRRNREARIDASAAAVILQDALSRLERRP
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 16316 Sequence Length: 151 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q28QB4
MIFETLDEFAGAVPPMRGLIGLDLGTKTIGVALSDRLLTSASALETVKRKKFGVDADALAGLIAKHEVGGIILGLPRNMDGSEGPRAQATRAFALNLSRRGDFAHLALGFWDERLSTVAAERALIAADTSRKRRSEVIDAVAASYILQGALDRLRHLRAV
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 17121 Sequence Length: 160 Subcellular Location: Cytoplasm EC: 3.1.-.-
A8Z5W0
MSKILCIDYGKKRIGLSITNSIRSIAFGLDTVNSNNIICTLYKYLKYEDIDTIVIGLPIRFDNSLFPIEKDIKKFIKIINNKYPKLIIKRIDERFTSKIANYYLINTRLKINQLKKNQNFLDKDKISATILLQEYIKY
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 16247 Sequence Length: 138 Subcellular Location: Cytoplasm EC: 3.1.-.-
A6WCF6
MRPGVRLAVDVGSVRVGLAACDPAGVIASPVRTLVRDPGHDADVAEIAAEARARGAVEIVLGLPLSLDGSEGPAALRALDYADKIVRSVPEVPVRLVDERLSTVGAHRALHAAGLKEKQFRAVVDQAAAVVLLQATLDAERTGHAPGRVVAGPKGRRKARHRGQGGTGTEQQADAGGRARPHATEGKG
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 19375 Sequence Length: 188 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q169F8
MILEDTADFLAALPSMRSLMGLDLGTQTIGVAVSDTFLSVATPLETVKRRKFTLDAARLSDIVAQRRLGGLVLGLPRNMDGSEGPRCQSTRAFARNLDKSIGSDLPITFWDERLSTVAAERALLEADTSRKRRAEVIDHVAAAYILQGALDRIRVIRAEQDQE
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 17896 Sequence Length: 163 Subcellular Location: Cytoplasm EC: 3.1.-.-
A5UY83
MSSEPGRVMALDVGERRIGVALSDPTRMLASPLTTIRAVPRSTALKRILTLIRDYQVTALVVGLPLTMNGDIGPQATLVQQFVDELRPLIDIPIFFVDERLTTVAAERMMIDLKIKPEQRRARIDEVAASIILQDFLDSQR
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15739 Sequence Length: 141 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q1AWA5
MSPPEGRVAALDLGEVWTGVAVSDPTRTLARPLEVVRTSELPGVLRRLVREEGVGEVLVGLPRTLRGEVGFQARRVSDRLSSLRAGFPEVRFVEWDERLTTKVVSGPLREGRRRGRRERVDHLAAARMLQEYLELGGGA
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Sequence Mass (Da): 15423 Sequence Length: 139 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q46856
MNNFNLHTPTRILFGKGAIAGLREQIPHDARVLITYGGGSVKKTGVLDQVLDALKGMDVLEFGGIEPNPAYETLMNAVKLVREQKVTFLLAVGGGSVLDGTKFIAAAANYPENIDPWHILQTGGKEIKSAIPMGCVLTLPATGSESNAGAVISRKTTGDKQAFHSAHVQPVFAVLDPVYTYTLPPRQVANGVVDAFVHTVEQYVTKPVDAKIQDRFAEGILLTLIEDGPKALKEPENYDVRANVMWAATQALNGLIGAGVPQDWATHMLGHELTAMHGLDHAQTLAIVLPALWNEKRDTKRAKLLQYAERVWNITEGSDDERIDAAIAATRNFFEQLGVPTHLSDYGLDGSSIPALLKKLEEHGMTQLGENHDITLDVSRRIYEAAR
Cofactor: Binds 1 zinc ion per subunit. Function: NADP-dependent ADH activity. Catalytic Activity: a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH Sequence Mass (Da): 42097 Sequence Length: 387 EC: 1.1.1.2
Q7T6X3
MSSRLSYVNVDDPNFYEFIDEKYSKYKIPPKQKTFKQFCFPSKYEFQIPQQFLAEYINPKTPYKGLLIYHRIGAGKTCTAIKIAENFKNKSKIMIVVPASLKGNFRSELRSLCADDHYLTSKERSELKILHPSSDEYKSIIKVSDDRIDKYYTIYSYNKFVDLIKQNKINLTNTLLIIDEVHNMISETGTYYESLYETIHSAPDNMRLVIMTATPIFDKPNEIALTMNLLVRNKQLPVGPDFVSTFMDIRYNSKGPVYHVKNMDLFKEFVKGYVSYYRGAPPYVFPKSELFFVRTKMSDLQKTVYQKITGKEVKQTKVRDYVNENISNNFFIGTRMISNIVYPNEKVGLKGYNSLTDEDLTIAKIREYSPKFLKILRKIKRCNGTVFVYSNFKEYGGIRVFARLLEFHRFKNYEFNGSGPRRFAIWSGDQDPIYKEEVKAVFNNKDNEFGSKIKVILGSSSIKEGVSFLRVQEVHIMEPYWNFSRMEQIIGRAIRFCSHKDVELDRQLVKVYIYLAVHPDIKMSIDERMMKMALDKKMINSAFEKALKEAAIDCELFKNANVYPGEQDIQCEQ
Catalytic Activity: ATP + H2O = ADP + H(+) + phosphate Sequence Mass (Da): 66973 Sequence Length: 573 Subcellular Location: Virion EC: 3.6.4.13
Q5UR49
MSLVPKAGYPFIIYFLDNINKYISDKTIQTYLTAFQINVDNLKVINKQFIPEAYRIIKLFTTNTTIMFAIYNYIFHGISKIGFLEKFSEEQIKYITDLETTDTKLIACAGSGKTRSVIGRIKFMVEHGLADKDEIYAITFSKHAATDFHRRIRELFPDYENFCQLKNFSTIDSMAKSILCRVKHHRSENVEILSIALRNFLKEATDEEINSITKFKIIKHLFIDEAQDLNNIQFDIALMFKKHFGTTIHLCGDPNQNIYQFRRSSNSYLMEFPAKKFELTLNFRSTQEIIDFSECLKPIATTRSVSGTNKIGPKVTIMTKQAIQIHKLILYFLKQYEKKNDLSNIAIICPTRGTGVNANTGLAMIFNFLKSNHIKVNQLYCESSSDERKRLVDRIPGHINLLTYHGTKGLEFDTVFVMDFYHSLLNIEPTYEEHNINQYLLYVATSRAISKMFICTYINNYGGYLNHWITKVDPKYYLIDSQPKIHKLTFRNEEIFDSNGVTELLEKLSEEDLYSIYELIKVNTFYEKRIFPDHTDIDRGKDEALYGIFCEELFYLCYYLNKKLEPRRFELIEKIVKSKFIIVENDLECNILKKFINTNNLTWTQFDQNKNNFRKDVIKLVEKYFSRNVELNDSIICTNDFINIVEANKIDIRDTYNRYLQPDKYQYNYNNIIFDLFYLVVVQYAYDINHYIYIK
Function: ATP-dependent DNA helicase. Catalytic Activity: Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction. Sequence Mass (Da): 81912 Sequence Length: 695 EC: 5.6.2.4
Q19238
MHHPKETLLIDSSNPSYSHLTEYRFDNLKREESRSTSLFGDRRRVMKILSGFSLIIIVVFIFATSHEQALSTTGDLTSSTQSTTHGGVVFTYPTTRKSPGKGCVLNSQRSTPKNLKQYTGNISDACLAGIKSSNCKTWLMTNAVILKYSDDVVSNCPSILEFVNKTSLSCSGKSQIQYMYPQSDSASSDCNHSYDFNSNALNRAIYNFNYSKTLISTSYANTPGFAMYTFLLKIMNCVNKNGIKLDAGILNIFTDMTYIDLCESDVFMSSFPDTLNKLIEAGYIVKFYFLNQNLQDTQKNVENVLAGCKYMNSRSYCEIVDWSYHSENPNEFEICIPDSQPSGKKEDFNWHVTELLLIIGIPCISLTICCIAFFVCCLKCAKLKMAMMRMNVFSNDTHQNPDEMELKKRWIGMRKKFNKDVENGSCKELNTQKWSHFASANNYMDIQALANANKKDIWEIDTKNLLVQEDHLLGNGAFANVYKGIVKGKIPLLVVNNSLNMTVESENNGHYEAAIKKLPAHADEQNHLDFFHEIDFMKRLGHHPHVISMLGCVSNPYEPLIVVEYCARGDLLKFLRRHKDYVLMNKTDDCPIEADMCLRIKDLVSIAWQVADGMSYLASKNFIHRDLAARNILLTKSLTAKVSDFGLCRYMDSALYTAKGGRLPIKWMSVEALKLYEFSTKTDVWSFGVLLFEIFSMGDVPYPTIQQVDMLEHLLAGGRLSQPLKCPNEIFNIMQKCWAEKPEDRPEFNEMRGEITVMLNLDDESYGYLSVESQGGPKYTQLTMQDSKETAPCSTPGGSQDMDEDGDYDSGSEGHSQGTCAQLDQVLTERFGEEQKKEIKQIFCEITSKSMRGKRRQSNSTVSTYQS
Catalytic Activity: ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 98103 Sequence Length: 867 Subcellular Location: Membrane EC: 2.7.10.1
O34760
METMKIGNITLTWLDGGVTHMDGGAMFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGIGYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGERLVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITMHHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQAFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: Probable hydrolase that is able to inhibit the signaling pathway required for the streptomycin production and development of aerial mycelium in S.griseus. Thus, serves as a defensive strategy against competing bacteria. The putative target for YtnP may be a gamma-butyrolactone termed A factor, which is the quorum-sensing signaling molecule that positively regulates streptomycin production and development of aerial hyphae in S.griseus. Sequence Mass (Da): 31801 Sequence Length: 281 EC: 3.1.1.-
O34707
MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDFRMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLLELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVAYSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMMDRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC
Function: Catalyzes the transformation of a linear C35 prenyl diphosphate chain to form tetraprenyl-beta-curcumene. Catalytic Activity: all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate Sequence Mass (Da): 42843 Sequence Length: 367 EC: 4.2.3.130
O32156
MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEPEKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFKFIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQKLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKDYNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEIKLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMGEKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTGVQQMLGGDMTPQQVMKAVQKAAKQVRASAE
Function: Probably part of the binding-protein-dependent transport system YurMNO. Location Topology: Lipid-anchor Sequence Mass (Da): 48027 Sequence Length: 422 Subcellular Location: Cell membrane
Q5WG37
MDLFFAYMFVASATPLFLWLEHRKIALASIPFIIVMWVLALAHIFDGFLFDLHHSAFVTAFLINVFIAHFAALVLYVYPHLRSKSRRFTQSTE
Function: Required for proper spore morphogenesis. Important for spore germination (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 10822 Sequence Length: 93 Subcellular Location: Spore membrane
P39603
MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFYATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS
Function: Required for proper spore morphogenesis. Important for spore germination. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 9959 Sequence Length: 87 Subcellular Location: Cell membrane
P54952
MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSYPFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVTDERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPDKKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAFPFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH
Function: Probably part of the ABC transporter complex YxeMNO that could be involved in amino-acid import. May transport S-methylcysteine. Location Topology: Lipid-anchor Sequence Mass (Da): 29311 Sequence Length: 264 Subcellular Location: Cell membrane
P54953
MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALITKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLKNAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGLLKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAMSKPYRT
Function: Probably part of the ABC transporter complex YxeMNO that could be involved in amino-acid import. May transport S-methylcysteine. Probably responsible for the translocation of the substrate across the membrane (Probable). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 25007 Sequence Length: 224 Subcellular Location: Cell membrane
P54954
MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLLRCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNITEALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHAILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHIIEQGTPEELFDHPKNERTKRFIKQVGEPAELI
Function: Probably part of the ABC transporter complex YxeMNO that could be involved in amino-acid import. May transport S-methylcysteine. Responsible for energy coupling to the transport system (Probable). Location Topology: Peripheral membrane protein Sequence Mass (Da): 27742 Sequence Length: 249 Subcellular Location: Cell membrane EC: 7.4.2.-
A2A288
MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP
Function: May regulate cell growth likely by suppressing RB1 phosphorylation . May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages . Serve as a tumor suppressor in certain leukemia cells . Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation . Sequence Mass (Da): 58078 Sequence Length: 527 Subcellular Location: Cytoplasm EC: 3.1.-.-
Q8BIY3
MEHRSKMEFFQKLGYSQEDVVRVLGKLGDSALVNDVLQELIQTGSRPRAQEDPASGTGVVLIPRGCCGVQDSAQQGPGTRPRRGWRRSSPLLRPIVIDGSNVAMSHGNKEAFSCRGIRLAVDWFTDRGHTYIKVFVPSWRKEPSRSDTPIREQHVLEELERQAVLVYTPSRKVNGKRVVCYDDRYIVKVAYEKDGIIVSNDNYRDLQNENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRRGPTLSNFLSKKPRPPEPSWQHCPYGKKCTYGVKCRFYHPERPHHGQLSVADELRAKTRAWLGGGAEEPRTPSARSRPTTARLLPQEPGEHDLPPAPQPAVLAALNRSFARLTFSDTAASGVVSQSRGPDWMPTGVPTSWAPPSLRAGSAATIGLPGMRSLRTPNNPLSPGDLGSPICPQARLSERHRSRDMHSDLPPQRRPLEDPWALLPSSYCYLNHSVWSESAWGEDIFRGPSESAQPVANGGGTRPVHCSFFPPDQDHPVMASGPPLSDMALLTLLQRSQKTGAPLGDP
Function: May regulate cell growth likely by suppressing RB1 phosphorylation (By similarity). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages . Serve as a tumor suppressor in certain leukemia cells (By similarity). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (By similarity). Sequence Mass (Da): 59340 Sequence Length: 533 Subcellular Location: Cytoplasm EC: 3.1.-.-
A0A0E0RTV6
MKLSPSKYLPVLLGTLSLTIANPSADCKCFPGDDCWPSAAEWKALNTSVSGNLIKTVPLGAPCHDPMFKGDVCQSLRQQWQNATIHFASSSSVMAPFFANQSCDPFQPRIRPCELGNYVSYAIAAETTSDVQNAIAFARANHIRLVIRNTGHDYLGRSTGAGALGVWTHHLKNIEFVDWDDDTYTGNAVKLGAGVQGFEVLEAARSRGLVVVGGECPTVGIAGGYSQGGGHSALSTSFGLSVDNVLSWEVITAKGELLTVNKDENPDLFWALRGGGGGTFGVVISMTVKAHPGTITSGASLSFSTDTNSEEAFWAGIQVFQDTLEDMVDAGTMVIHIITNTSFLIAPLTAYNKTEAQVKVIMKPFISSLTSKHVDFDVTYKESKTYYDHYNEFLGPLPYGKIRVGFEQYGGRLIPRSVVPNFTETLRQVTNMGVTWVGVATDVGPFGTRATTSVHPAWRSTLVHALLSTPWDFTKPWHDMIKLQDLMTNVIMPKVEAVTPGSGAYVNEADFRQPNYQDVFWGDNYKDLLEVKEKWDPEHFFFVPKGVGSEIWSIAEDGRMCKSAL
Function: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals . The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules . The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation . The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide . ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis . ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone . ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway . Sequence Mass (Da): 61683 Sequence Length: 565 Pathway: Mycotoxin biosynthesis. EC: 1.-.-.-
E9Q8G5
MVRRRQRLPEVDMGLVSFEDVAVDFTWQEWQELDAAQRTLYRDVMLENYRSLVWLGHCLAKPELISKLEEGFEPWGVAEATEQCLPGVRKWSAPVEKGQQSQEKYLRQVKIIKKNTPDEDKVEVENTYNVDSNCISNMTLKNEVCSRVFFQELVNPLLDVPLPTEAGERQSTEVPHDLNRTQEVLSYPKHFTHHSKDQYSQCCFQYFGPDEAFHTKAILTPEMFYVQETSRTCNNYDKSFDEVTIPAQYMTQLRKQTLGWNICHKIFPNKTELSNHDAMHTGENDDKCDYEKPIINKSLYLTKHQEAHAGIEPQAHKENIKFFCLDAELQTVDPELHGEKQVYECKVSGKTFRHQPEHISQQRPHACERACQAKEHGEAGCDEPALTQHQRLCTEEKACEGKACSKAFHHKSLLPQYQSARADEQQSDCKELMKIYFYVSSPTQHHGPPPPEKPFRCNDCLKTFSHKSQLERHQRMHTGEKPHECKECRKAFCHKSHLIRHQGIHAPEKPYECNECKKSFYLRSQLTLHERTHTGEKPFECKECRKAFSRNSHLTQHQKIHTGEKPHKCKECGNAFARKSHLIQHQKTHTGERPYECKECRKAFSRKSQLMQHETTHTGERAYECKECRKTFYLKAYLTRHQVIHQSEKPFECKKCGKAFSRKSYLTRHQKIHKGQTLSG
Function: May modulate osteogenic differentiation, at least in part, through the bone morphogenetic protein (BMP) signaling pathway, increasing RUNX2 activation and leading to osteoblast commitment and maturation. PTM: Polyubiquitinated, leading to its degradation via the ubiquitin-proteasome pathway. Sequence Mass (Da): 79457 Sequence Length: 680 Subcellular Location: Nucleus
P34447
MKEMVGGCCVCADENGWTDNPLIYCDGENCEVAVHQGCYGIQEVPEGEWFCAKCTKASAMMPGSINEATFCCQLCPFDYGALKKTDRNGWAHVICALYIPEVRFGNVHSMEPVILNDVPTDKFNKLCYICNEERPNDAKKGACMSCNKSTCKRSFHVTCAQRKGLLCEEGAISRNVKYCGYCENHLKKAINDPAIKVIPACPPVQRLSKEQDKKKTVLLTSLPLPPPAPRLHMLADPLPIKSNKVNNVLGLGSAINAVSLEERPASGSTVNSGIFVPPPTAFSPPLTTSSRSSVAQDPSPPLTINKNSLSSSGPLIPSTAHLSATTASATPIMANGSTLPPSSETTVGTHCLQQLQIQSAAAAAITQNQIGPSELNGYPAASQLSSFMHEIPARNTTSVASLLPPGAAEYHLNGSGDEEKTVKAVLTAPLTKAKRIRDSKNDMMDKTHKRPRANARPPAVLGSMSSGSSGGTVGKSPSMQRLQNLVAPIVSETVTDFQRDRVADRTAAERRAAAAQSQPSTSTNGGPNVTIPAVVEVHTNSTNSTNHQNNGLTQNAPASTSMQAGTSSNDGVISQNGTSSTSQSNRLNLPSFMEQLLERQWDQGSSLLMANAHFDVAQLLSCLFQLKSENFRLEENLSGLRKRRDHLFALNSRLAEVNTLDVSKRQRSDGLLLQQQIAHHLDPTSIVPKAEVHKQEPLSAPTSVPLPANHSSSLFEDIKAPKATYSRKTPSNIPLTVPLSTAATALTTTTAASSGAPVNSNIQNHRATPSTAGAPMAATPIMTAVTSANELAALSPERAQALLNMYRMPLDANVAAQLSMITNFPGQVNPSLFSRLLAVNMMNGGLQPNGQPLSALPPPTSATPNGK
Function: Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription . Recognizes and binds histone H3 methylated at 'Lys-4' (H3K4me) at the promoters of target genes . During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes . In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated gene expression . Thus, most likely via this mechanism, in response to stress, it confers a protective role against neuronal necrosis . Plays a role in Insulin/IGF-1-like signaling (IIS)- and diet restriction-mediated lifespan extension by controlling daf-16/FOXO and pha-4/FOXA recruitment to target promoters . May negatively regulate the expression of genes required for vulval development . May play a role in axon guidance in D-type motor neurons . May suppress sensitivity to RNAi . Sequence Mass (Da): 92190 Sequence Length: 867 Domain: The PHD-type zinc finger 1 most likely mediates nuclear localization. Subcellular Location: Nucleus
Q5QLR5
MAYRNTVCTPQVIDLETEQGHSHIHSESFNRTGNDSSDQGAQHAVRGVGNATNIGLSDMRSYYDAGMNHPHQPVHNLPPNLGVDSGFVFPSSMYNPCMSTTSMNQYVSHTQSFGLPSNQVVLGSMDEGSRNENAGESARGFIKRKNAAVAGSYHCANGFASSSSSHASLNPTHRPWDPSFESNVLPNTASYNPSEYHSQTSWPSMEGSSIPSNGFNLMGAHPESAQHGNYAFPTSHISQCFQPTSNTWISQSANGIADGIPQWEYVNGMNNAPGRFSRSGMTETVNGSFREYQNGPSTLCRGPLPYFHQHAGMHAHNLLDHTQVQAPYQQCHNNPVLHGVNHSGNRFHLGPRIPVLFSNSERTFGPPHHPLLANPVNHRNIRILPPEHATIMDFSRLYEVSNVVDEHRDMRLDIDSMTYEELLALEEQIGDVNTGLAKSYIVEKLKTSLFVPGSSCMSNKSSESSMENDACIICQEEYQVKECIGTLDCGHRYHEDCIKQWLMVKNLCPICKTTALSTGRRSG
Function: Probable E3 ubiquitin-protein ligase. Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Sequence Mass (Da): 57682 Sequence Length: 523 Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. Pathway: Protein modification; protein ubiquitination. EC: 2.3.2.27
Q9FKJ9
MSSLSKPNRQFLSPTTNNQDTGREQTIACARDMVVLYNECLKNHAVSLGGHALDGCGEFTPKSTTILTDPPSLRCDACGCHRNFHRRSPSDGFSQHRSPPSPLQLQPLAPVPNLLLSLSSGFFGPSDQEVKNKFTVERDVRKTAMIKKHKRTKFTAEQKVKMRGFAERAGWKINGWDEKWVREFCSEVGIERKVLKVWIHNNKYFNNGRSRDTTSSMSLNLKL
Function: Putative transcription factor. Sequence Mass (Da): 25237 Sequence Length: 223 Domain: The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2. Subcellular Location: Nucleus
Q9FMY7
MDEIKPKKEENSKRRRNVKPICRETGDHVHYLPTCKTKPKPTRTHHAPPPILDSIFKVTHKPHYYECRKNHAADIGTTAYDGCGEFVSSTGEEDSLNCAACGCHRNFHREELIPENGGVTETVLEVLKISSCQFRRIFCSPYGGGKSEGKKKKKEKESYGGDPIIKDRFGGAEEEEGIVKRLKTKFTAEQTEKMRDYAEKLRWKVRPERQEEVEEFCVEIGVNRKNFRIWMNNHKDKIIIDE
Function: Putative transcription factor. Sequence Mass (Da): 27968 Sequence Length: 242 Domain: The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2. Subcellular Location: Nucleus
Q9LQW3
MQSTCVYRECMRNHAAKLGSYAIDGCREYSQPSTGDLCVACGCHRSYHRRIDVISSPQINHTRFPFTSLRRVKQLARLKWKTAEERNEEEEDDTEETSTEEKMTVQRRRKSKFTAEQREAMKDYAAKLGWTLKDKRALREEIRVFCEGIGVTRYHFKTWVNNNKKFYH
Function: Putative transcription factor. Sequence Mass (Da): 19923 Sequence Length: 168 Domain: The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2. Subcellular Location: Nucleus
Q9FKP8
MEFEDNNNNNDEEQEEDMNLHEEEEDDDAVYDSPPLSRVLPKASTESHETTGTTSTGGGGGFMVVHGGGGSRFRFRECLKNQAVNIGGHAVDGCGEFMPAGIEGTIDALKCAACGCHRNFHRKELPYFHHAPPQHQPPPPPPGFYRLPAPVSYRPPPSQAPPLQLALPPPQRERSEDPMETSSAEAGGGIRKRHRTKFTAEQKERMLALAERIGWRIQRQDDEVIQRFCQETGVPRQVLKVWLHNNKHTLGKSPSPLHHHQAPPPPPPQSSFHHEQDQP
Function: Putative transcription factor. Sequence Mass (Da): 31098 Sequence Length: 279 Domain: The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2. Subcellular Location: Nucleus
Q6YXH5
MDFDDHDDGDEEMPPMPVSSSYETPPQHGLAGGGMAPKPPGEIGSRVKGPSCGGGRYRECLKNHAVGIGGHAVDGCGEFMAAGEEGTIDALRCAACNCHRNFHRKESESLAGEGSPFSPAAVVPYGATPHHQFSPYYRTPAGYLHHHQHHMAAAAAAAAAAAGGYPQRPLALPSTSHSGRDDGDDLSGMVGPMSAVGPLSGMSLGAGPSGSGSGKKRFRTKFTQEQKDKMLAFAERVGWRIQKHDEAAVQQFCDEVGVKRHVLKVWMHNNKHTLGKKLP
Function: Putative transcription factor. Sequence Mass (Da): 29541 Sequence Length: 279 Domain: The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2. Subcellular Location: Nucleus
Q9SB61
MNFEDQEEDMEMSGVNPPCGYDSLSGEGATSSGGGGVGRSKGVGAKIRYRECLKNHAVNIGGHAVDGCCEFMPSGEDGTLDALKCAACGCHRNFHRKETESIGGRAHRVPTYYNRPPQPHQPPGYLHLTSPAAPYRPPAASGDEEDTSNPSSSGGTTKRFRTKFTAEQKEKMLAFAERLGWRIQKHDDVAVEQFCAETGVRRQVLKIWMHNNKNSLGKKP
Function: Essential protein. Putative transcription factor. Sequence Mass (Da): 24023 Sequence Length: 220 Domain: The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2. Subcellular Location: Nucleus
A2YWA6
MDFDDHDEGDGDEEMPPMPLSSGYDAPMQPGLGGGGGGVPKPGGGVGGGGGGGGGGGGGGARYRECLKNHAVGIGGHAVDGCGEFMASGEEGSIDALRCAACGCHRNFHRKESESPTGVGPAEPSAVSPAAISAYGASPHHQFSPYYRTPAGYLHHQQHQMAAAAAAAAAAAAGGYPQRPLALPSTSHSGRDEGDDMSGMVGPMVIGPMVGMSLGSAGPSGSGSGKKRFRTKFTQEQKDKMLAFAERLGWRIQKHDEAAVQQFCEEVCVKRHVLKVWMHNNKHTLGKKAP
Function: Putative transcription factor. Sequence Mass (Da): 29759 Sequence Length: 290 Domain: The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2. Subcellular Location: Nucleus