ids
stringlengths
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seqs
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11.1k
P81528
VAVKATTTEEETEIPAK
Function: Hydrolyzes the cell walls of mycobacteria. May play an important role in cell wall growth and cell separation. PTM: The N-terminus is blocked. Sequence Mass (Da): 1817 Sequence Length: 17 EC: 3.2.1.-
P06653
MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWRKDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGISREQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLADRWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK
Function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolysin strictly depends on the presence of choline-containing cell walls for activity. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 36544 Sequence Length: 318 Domain: The C-terminal domain could be responsible for the substrate recognition. Subcellular Location: Secreted EC: 3.5.1.28
P36548
MSTFKPLKTLTSRRQVLKAGLAALTLSGMSQAIAKDELLKTSNGHSKPKAKKSGGKRVVVLDPGHGGIDTGAIGRNGSKEKHVVLAIAKNVRSILRNHGIDARLTRSGDTFIPLYDRVEIAHKHGADLFMSIHADGFTNPKAAGASVFALSNRGASSAMAKYLSERENRADEVAGKKATDKDHLLQQVLFDLVQTDTIKNSLTLGSHILKKIKPVHKLHSRNTEQAAFVVLKSPSVPSVLVETSFITNPEEERLLGTAAFRQKIATAIAEGVISYFHWFDNQKAHSKKR
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors. PTM: Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 31412 Sequence Length: 289 Subcellular Location: Periplasm EC: 3.5.1.28
P57638
MSKKITILIDAGHGGYDPGAIGIRGLKEKNINIEIALKLEKLLNHDKMFCTILTRHNDSYLSLKKRKQLLKKNQVNFLISIHADSSRKQNVSGASIWIVSKTRINREINNYLKNKSTLLFSKKIENIFKQNKNDFFLKKTILDLQSNNFQKIELDLSKEILKQLEKNTKLNKKYPNYASLGILSSINTPSILIETGFITNILEGKKLKTTNYQNKIANSIYLGLKNYFTKSSYILKK
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 27240 Sequence Length: 237 Subcellular Location: Secreted EC: 3.5.1.28
Q8K908
MIDPGHGGQDPGAINSLGLQEKKITLKIGIKLKNLLQNSDLFYPVLTRNDDSYVSLKKRRDFLKNNHVSFLISIHADSSKKRYVSGASIWITTNDRMHREINNFIKNREENIYFPKNIQNLIQKNKHDFFLKKTVLDLQFNNFQKMEINLSRYIFQQLKKIIKLDKINLNYASLGILSSINTPSMLIETGFITNFLEEKKLRTNKYQNKIANAIYIALKNYFQDRLLSNLRNT
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 27259 Sequence Length: 233 Subcellular Location: Secreted EC: 3.5.1.28
Q89A33
MIIAIDAGHGGQDPGAIGKNKFQEKNITLSIAKKLTKLLNHTNFFKAVMIRRGNYFLSVFKRTQIAEKYHANLLISIHANSSKNRKISGVSIWVLPKNVHNTRIQKHKLNKKTKNIHKKINTKTSKFKNFYEIEYDLAKIIIQELRKVSTLNQKKPKYAKFGILKFSQFPSILVETGFISNPIEEQHLNKKFYQNLISKSISIALKKYFLKRIKQYN
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 25202 Sequence Length: 217 Subcellular Location: Secreted EC: 3.5.1.28
P26365
MMYRIRNWLVATLLLLCTPVGAATLSDIQVSNGNQQARITLSFIGDPDYAFSHQSKRTVALDIKQTGVIQGLPLLFSGNNLVKAIRSGTPKDAQTLRLVVDLTENGKTEAVKRQNGSNYTVVFTINADVPPPPPPPPVVAKRVETPAVVAPRVSEPARNPFKTESNRTTGVISSNTVTRPAARATANTGDKIIIAIDAGHGGQDPGAIGPGGTREKNVTIAIARKLRTLLNDDPMFKGVLTRDGDYFISVMGRSDVARKQNANFLVSIHADAAPNRSATGASVWVLSNRRANSEMASWLEQHEKQSELLGGAGDVLANSQSDPYLSQAVLDLQFGHSQRVGYDVATSMISQLQRIGEIHKRRPEHASLGVLRSPDIPSVLVETGFISNNSEERLLASDDYQQQLAEAIYKGLRNYFLAHPMQSAPQGATAQTASTVTTPDRTLPN
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 47985 Sequence Length: 445 Subcellular Location: Periplasm EC: 3.5.1.28
P44493
MKTKILFFLFFSTFSFSIFAAPITIAIDPGHGGKDPGAISRNLGIYEKNVTLSIAKELKALLDKDPHFRGVLTRKSDYYISVPERSEIARKFKANYLISIHADSSKSPDRRGASVWVLSNRRANDEMGQWLEDDEKRSELLGGAGKVLSHNNDKYLDQTVLDLQFGHSQRTGYVLGEHILHHFAKVTTLSRSTPQHASLGVLRSPDIPSVLVETGFLSNSEEEKKLNSQTYRRRIAYMIYEGLVAFHSGKTNTLVKDNLVQNIKQNDIKKSGKNNRTSEQNINEDNIKDSGIRHIVKKGESLGSLSNKYHVKVSDIIKLNQLKRKTLWLNESIKIPDNVEIKNKSLTIKENDFHKKQNSLVNNTNKDLKKEKNTQTNNQKNIIPLYHKVTKNQTLYAISREYNIPVNILLSLNPHLKNGKVITGQKIKLREK
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 49109 Sequence Length: 432 Domain: LysM domains are thought to be involved in peptidoglycan binding. Subcellular Location: Periplasm EC: 3.5.1.28
P26366
MIYRIKNAVIAALILLCAQAGAASLSDIQVSNGEQQARITLSFIGEPEYAYSQDGKRTVALDIRQTGVIQGLPLQFSGNNLVKTIRAGTPKDAQSLRLLVDLTENGKTEAVKRQNGGNYTVIFTINADVPPPPPPVVAKRVESAPRPTEPARNPFKSSDDRLTGVTSSNTVTRPAARASAGAGDKVVIAIDAGHGGQDPGAIGPGGTREKNVTIAIARKLRTLLNNDPMFKGVLTRDGDYFISVMGRSDVARKQNANFLVSIHADAAPNRDATGASVWVLSNRRANSEMANWLEQHEKQSELLGGAGDVLANSQSDPYLSQAVLDLQFGHSQRVGYDVATNVLSQLDGVGSLHKRRPEHASLGVLRSPDIPSILVETGFISNHGEERLLASDRYQQQIADAIYRGLRKYFAAHPIQSAPQGGPGQTASTNQPGAITAAN
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 46790 Sequence Length: 439 Subcellular Location: Periplasm EC: 3.5.1.28
P63884
MSGSNTAISRRRLLQGAGAMWLLSVSQVSLAAVSQVVAVRVWPASSYTRVTVESNRQLKYKQFALSNPERVVVDIEDVNLNSVLKGMAAQIRADDPFIKSARVGQFDPQTVRMVFELKQNVKPQLFALAPVAGFKERLVMDLYPANAQDMQDPLLALLEDYNKGDLEKQVPPAQSGPQPGKAGRDRPIVIMLDPGHGGEDSGAVGKYKTREKDVVLQIARRLRSLIEKEGNMKVYMTRNEDIFIPLQVRVAKAQKQRADLFVSIHADAFTSRQPSGSSVFALSTKGATSTAAKYLAQTQNASDLIGGVSKSGDRYVDHTMFDMVQSLTIADSLKFGKAVLNKLGKINKLHKNQVEQAGFAVLKAPDIPSILVETAFISNVEEERKLKTATFQQEVAESILAGIKAYFADGATLARRG
Function: Cell-wall hydrolase involved in septum cleavage during cell division. PTM: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 45634 Sequence Length: 417 Subcellular Location: Periplasm EC: 3.5.1.28
Q9K0V3
MIKLTRRQIIRRTAGTLFALSPIASAVAKTVRAPQFTAARIWPSHTYTRLTLESTAALKYQHFTLDNPGRLVVDIQNANINTVLHGLSQKVMADDPFIRSIRAGQNTPTTVRLVIDLKQPTHAQVFALPPVGGFKNRLVVDLYPHGMDADDPMMALLNGSLNKTLRGSPEADLAQNTTPQPGRGRNGRRPVIMLDPGHGGEDPGAISPGGLQEKHVVLSIARETKNQLEALGYNVFMTRNEDVFIPLGVRVAKGRARRADVFVSIHADAFTSPSARGTGVYMLNTKGATSSAAKFLEQTQNNADAVGGVPTSGNRNVDTALLDMTQTATLRDSRKLGKLVLEELGRLNHLHKGRVDEANFAVLRAPDMPSILVETAFLSNPAEEKLLGSESFRRQCAQSIASGVQRYINTSVLKRG
Function: Cell-wall hydrolase involved in septum cleavage during cell division. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 45190 Sequence Length: 416 Subcellular Location: Periplasm EC: 3.5.1.28
P0A4M7
MKKYIFMRVLRSLVSIFLVTTLTYTIIYTLVPRKLIFKQDPNYNKIATTADKRDNYENTVFERMGYIEYYDTKELQEKASSMDSSVTVEANATNKAIYEKYINQLGHGWTLGEFTESGQFYATREIPIFERVFHFYANLIDIDHTNKIQDPENPDLKRYLRFENDPAIGWSLVGSGTKHKYLLYFNSQFPFVHQNFVNLNLGDSYPTYANTPVLQVITQGQGQTKTAQVQFPTGKKTSSVNIYSRTYKSPSQADSREVASYGKDDPYTATESNYQYPSMIVSSAITGLIGLVLAYALAVPLGSAMARFKNTWIDSLSTGALTFLLALPTIALVYIVRLIGSSIALPDSFPILGAGDWRSYVLPAVILGLLGAPGTAIWIRRYMIDLQSQDFVRFARAKGLSEKEISNKHIFKNAMVPLVSGIPAAIIGVIGGATLTETVFAFPGMGKMLIDSVKASNNSMVVGLVFIFTCISIFSRLLGDIWMTIIDPRIKLTEKGGK
Function: Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55623 Sequence Length: 498 Subcellular Location: Cell membrane
Q8EI85
MALACLNSLNANAEIFSFDTRNSLNSDTLVLFHSADSTTYSLDFLPQSTQDQLNLAVADNSFSGKRGEVLEILVPSEIDAKRVLLVGIGDAKTLTPGEINALGGNIAAKLETVPQATVRVLTQGLNNAPLFGSELAHGIELRSYRYTQFKASNRVEKNYQIGVDDLSLNQKHHKNLQAVEAGVFLARDLTNAPAGNMYPESFANEARKLKSLGVKVTVLEAKDIERLNLGALAAVGKGSERPPKLVVAHWPGSKEAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTVKAMAIQKAPVNLVAIMPMAENMVSGHAMIPGDVITTAQGLTVEVLNTDAEGRLVLADGLWYARENYRPSVIIDVATLTGSKVSALGTVYAGLFTDSEPLVQQLTFAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASAAAMFLKRFAGDQPWAHLDIAGHALTATDTAVVPAGATGYGVRLLSTWLTQPKAQN
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity). Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 53027 Sequence Length: 500 Subcellular Location: Cytoplasm EC: 3.4.11.1
Q6FFD8
MKFTLQSTAPQSAQHEYLLVLVTEQQLKNTADTYKINTLDTITHTSQFKSGFNEVLTLIGQAETCSYLNLVGLGDLKDLQPAKIAKLAQTIIKLVQTKFKQIHLDISALPIELHYLFALNLTQANYVFDEFKSKKSEAQLEQIHLITAQTGLTTQQLDLIQAIASGQDLARDLGNRPGNICFPEYLADQAKALAHEFPELLKVTILDEQQMADLGMNAFLAVSQGSDRPGRIITLEYNAQLEQAPVVLVGKGVTFDTGGISIKPAQGMDEMKFDMCGAASVLGTIRTLCEARLPIHVVGAVAAAENMPSGQATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPSLVIDIATLTGACVVALGKVVSGLFSPDDALAQELQQAGEQSFDRVWRLPVMDDYQELLDSPFADIANIGGPYGGAITAACFLQRFTRDYRWAHLDIAGTAWLSGTAKGATGRPVPLLVQFLANRVGTND
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 52317 Sequence Length: 482 Subcellular Location: Cytoplasm EC: 3.4.11.1
B0VMG3
MKFTTYTTFPEQTSNESLWILVDSEQLQSNLNTYQINNLESILTATQFKANFNETLPLFGQLSTQPHSQLLGLGKAAELQAAKLAKLAQTIIKSAQNKFKHIAIDIAALPVEYHYLFALSLTQAAYGYDEFKSTKNEFVLQQVDLISSQTSLDENQLALVHAVQSGQSYARDLGNRPGNICFPEYLAEQALALAAEFPDLLKVTVLNEQQMADLGMYAFLAVSKGSERPGRIVTLEYQAQLEQAPVVLVGKGVTFDTGGISLKPGLGMDEMKFDMCGAASVLGTIRALCEARLPIHVVGAIAAAENMPSGKATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPAVVIDIATLTGACVVALGKVLSGLFSPDDTLAAELQQAGEQSFDRVWRMPVIDDYQELLDSPFADIANIGGPHGGAITAACFLERFTRDYRWAHLDVAGTAWLSGSAKGATGRPVPLLMQFLANRVSTNG
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 52150 Sequence Length: 482 Subcellular Location: Cytoplasm EC: 3.4.11.1
C1F4B7
MKTTLVSTPLAQLETELLAVFATDTAPAADMANGTQASPQVQLLTRDAALDAAVKTILASGDFKAEANETLLIHAPQGMAARRLLLVGAGKQARFTVHALRKAAGSAVRAARAKNIREATLAIPQSQGLDVTATARALGHGAAVADFDPDFYRSDRKDKSLQSLTLALPEATDANAAEAGLREGIALGESQNLTRTLVNEPGNRLTPTLLGEQAKKMCAEQGLRCQVYSSEKLHELKMGSFWSVTQGSDEPPALIVMEYTPEGAAEGPVLGLVGKGITFDSGGLSLKPADSMEKMKYDMAGAAAMIGAMRAIALLKPRIKVISVICSAENMPSGKAQKPGDVQISMIGKSIEVLNTDAEGRLVLADGLAYAKQLGATHLIDAATLTGAVMVALGGVNAGVFCNDEEAWQHFEAALGQSGEKFWRLPLDEEYREMLRSPIADIKNVGGRYGGASTAAMFLKEFVGDTPWVHLDIAGTAWMDEAKPWMSSGPSGIAMPSIVEWVRSFAR
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 53618 Sequence Length: 507 Subcellular Location: Cytoplasm EC: 3.4.11.1
P45334
MKYQAKNTALSQATDCIVLGVYENNKFSKSFNEIDQLTQGYLNDLVKSGELTGKLAQTVLLRDLQGLSAKRLLIVGCGKKGELTERQYKQIIQAVLKTLKETNTREVISYLTEIELKDRDLYWNIRFAIETIEHTNYQFDHFKSQKAETSVLESFIFNTDCAQAQQAISHANAISSGIKAARDIANMPPNICNPAYLAEQAKNLAENSTALSLKVVDEEEMAKLGMNAYLAVSKGSENRAYMSVLTFNNAPDKNAKPIVLVGKGLTFDAGGISLKPAADMDEMKYDMCGAASVFGTMKTIAQLNLPLNVIGVLAGCENLPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDVATLTGACVVALGQHNSGLVSTDNNLANALLQAATETTDKAWRLPLSEEYQEQLKSPFADLANIGGRWGGAITAGAFLSNFTKKYRWAHLDIAGTAWLQGANKGATGRPVSLLTQFLINQVK
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity). Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 53529 Sequence Length: 491 Subcellular Location: Cytoplasm EC: 3.4.11.1
A1WUV1
MELKTKSGDPARQRTACVVVGVYERRRMSEAARAVDAASDGYLSHLLRRGDLEGEAGQTLLLPDCPGVRTDRVLLVGCGRERDFNERTYRKAVTAAARALEQAGTGEAILFLPELPVRGRDVAWRVAATAEILETTLYRFDTYKSDPRPPRRPLRQATLAVPRRADLRRAQPALTLGQAAGRGANFSRDLGNTPANICTPGYLGEQAEALAQRFDGVRAEILGPAELEEQGLAALLAVARGAEAPPRLVVLHYRGADDDQAPVALVGKGITFDSGGISIKPSASMDEMKYDMSGAAAVFGAVHAAAEAQLPLNLVAVIPATENMPDGRATRPGDIIDSLDGQRIEVLNTDAEGRLVLADGLAYARRLEPSEVVDVATLTGAAIIGLGHHRHAVMGNAPGLVRDLLQAGERAADRGWELPLDEEYDEQLRSPFADVANIGGQPAGTITAGCFLQRFARGLRWAHLDIAGTAWKSGEHKGATGRPVPLLTHFLAGRAGWTL
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 53334 Sequence Length: 499 Subcellular Location: Cytoplasm EC: 3.4.11.1
Q7VGF0
MKVSISHKNNFKGVSYQAQALLMSKSVFAKSPYAKLCKSFGFEGEGKFFLQEQALLLVCVEELGLDSIREAGASIARHFRTLPYKNVNVALNGKLDDSKAYALLLGALLGVYECVSYKTKTPPLHLKEIILLDEKNEVASESVLKKVHIVAQSVNEVREIINTIPQVATPKYLAKYAKELSKEVGNLECKILDEEALQKEKMGAFLAVNRASCNPPRLIHLSYKPKGAKKRIVLVGKGLTYDCGGLSLKPADFMVTMKADKSGGCAVMGIIKAIAQLGANIEVHSIIGAAENMIGGNAYKPDDVLYSREGKSIEVRNTDAEGRLVLVDCLSYAQDLKPDILIDFATLTGACVVALGEFTSGIMGHNDRLKAQFEKCALESGELMATLPFNRHLKKLIESKIADVCNVGSSRYGGAISAGLFLSEFIREEFKQKWLHIDIAGPAYVEKEWDINPSGASGAGVRAGIEFILAQGKA
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 51523 Sequence Length: 474 Subcellular Location: Cytoplasm EC: 3.4.11.1
O25294
MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGAHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSAKEALKYAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA
Cofactor: Binds 2 manganese ions per subunit. Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity). Catalytic Activity: Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. Sequence Mass (Da): 54433 Sequence Length: 496 Subcellular Location: Cytoplasm EC: 3.4.11.1
Q9H4A4
MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLSGTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFFFQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS
Cofactor: Binds 1 zinc ion per subunit. Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). Catalytic Activity: Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys. Sequence Mass (Da): 72596 Sequence Length: 650 Subcellular Location: Secreted EC: 3.4.11.6
O09175
MESSGPSSCHSAARRPLHSAQAVDVASASSFRAFEILHLHLDLRAEFGPPGPGPGSRGLNGKATLELRCLLPEGASELRLDSHSCLEVMAATLLRGQPGDQQQLTEPVPFHTQPFSHYGQALCVVFPKPCCAAERFRLELTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALVEVPDGFTAVMSASTWERRGPNKFFFQMSQPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDVSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQEQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFNRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWAASEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDHQEEFWKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKETFSATASQLHSNVVNYVQQILAPKGS
Cofactor: Binds 1 zinc ion per subunit. Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4). Catalytic Activity: Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys. Sequence Mass (Da): 72620 Sequence Length: 650 Subcellular Location: Secreted EC: 3.4.11.6
P00811
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 41556 Sequence Length: 377 Subcellular Location: Periplasm EC: 3.5.2.6
Q48743
MKRLLAFCLLFFAALGQAKVPPPARSAADAEIQRAVAAFMQQYQVPGVAVGITVDGAERYYNYGVSSRKTQAKVGANTLFEVGSVSKTFTATLASYAQVNQQLSLADHPGKYLPEMKGHDFDKVTLLNLGTHTAGGFPMQVPTQVKTDQQLTAYFQSWHPQYPAGTKRTYANPGIGMLGVIAAKSMRMPFQKAMTGVLLPKLGLTNTYLTVPPAKMAFYAQGYDDKGQPVRMSPGALWEPTYGIKTTARDLLRFVEINLDQVKVEPKLKRAIDGTHVGYYRLGEMTQGLVWEQLPYPASETSLQANSSQKVIFESNAVAALTPPRPPQANVLINKTGSTRGFGAYVAFNPARKIGIVLLMNRSVPMDGRIKLAHTILDTAGGMAK
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 41878 Sequence Length: 385 Subcellular Location: Periplasm EC: 3.5.2.6
P94958
MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 41272 Sequence Length: 379 Subcellular Location: Periplasm EC: 3.5.2.6
O69773
MDNSMKNIFRQGRLFIALSLAMTSISAFALTQQEVDDIIKPLMKQEQIPGMSVAISVNGKQAIYHYGVQSKQTQIPVSDRTLYEIGSLSKTFTATLATYAQIQGKLDFSQSVSHYLPELKGSAFDNVSVMNLATHTSGLSLFVPSDIKTNDQLMAYYQKWLPDNEVGQYRSYSNLGVGLLGIVTAKQLNMPFSQAMEKLMLPSLGLKHTYIHVPKSQEKYYAQGYNKQNQPVRLNLEILGPEAYGLKSNAKDLIRYLEINMQSIKVAKTWQEAIENTHTGVYLTDSFVQDMMWESYPWPVSLSQLLQGNRDDMALKPQKVELIKPAMAPEVRAYYNKTGSSNGFATYAIFIPEEKIAIVMLSNKWIPIPQRITATYQLLEKIER
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 43366 Sequence Length: 384 Subcellular Location: Periplasm EC: 3.5.2.6
P24735
MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 43401 Sequence Length: 397 Subcellular Location: Periplasm EC: 3.5.2.6
P85302
ATDIRQVVDSTVEPLMQQQDIAGLSVAVIQNGKAQYFNYGVANKDSKQPITENTLFEIGSVSKTFTATLAGYALANGKLKLSDPASQYLPALRGDKFDHISLLNLGTYTAGGLPLQFPEESDNTGKMISYYQHWKPAFAPGTQRLYSNPSIGLFGHLAAQSLGQPFEKLMEQTVLPKLGLKHTFISVPETQMSLYAQGYDKAGKPVRVSPGALDAEAYGIKTSTSDLIHYVEVNMHPAKLEKPLQQAIAATHTGYYTVDGMTQGLGWEMYPYPIKVDALVEGNSTQMAMEPHKVNWLTPPQAAPLDTLVNKTGSTGGFGAYVAYVPSKGLGVVILANKNYPNAERVKAAHAILSAMDQ
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 38728 Sequence Length: 358 Subcellular Location: Periplasm EC: 3.5.2.6
O05465
MKLFTSTLTAKKSSTHKPLISLALSVLISTLLISETAQAADANDRLEQEVDKQAKQLMAQYQIPGMAFGIIVDGKSHFYNYGLADKQRNQPVSEDTIFELGSVSKTFAATLASYSELNGTLSLDDTADKYIPYLKNSAIGNTKLISLVTYSAGGYHYRCLKTLENNKELLQYYKSWHPDFPVNSKRLYSNASIGLFGYISALSMHSDYTKLIENTVLPSLKMTNTFVDVPANKMEDYAFGYNAAGEPIRVNPGMLDAEAYGIKSTSADMTRFMAANMGLVTVDSQMQQALDNNRKGYYRTKSFTQGLAWEMYPLPTTLQQLVEGNSTETILQPQPIQLNEPPTPVLNDVWVNKTGATNGFGAYIAYMPAKKTGMFILANKNYPNTERVKAAYTILDSVMNN
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 44451 Sequence Length: 401 Subcellular Location: Secreted EC: 3.5.2.6
P18539
MTKMNRCAALIAALILPTAHAAQQQDIDAVIQPLMKKYGVPGMAIAVSVDGKQQIYPYGVASKQTGKPITEQTLFEVGSLSKTFTATLAVYAQQQSKLSFKDPASHYLPDVRGSAFDGVSLLNLATHTSGLPLFVPDDVTNNAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPFIQAMEQGMLPALGMSHTYVQVPAAQMANYAQGYSKDDKPVRVNPGPLDAESYGIKSNARDLIRYLDANLQQVKVASVARRWPRRTSVITSAGAFTQDLMWENYPYPVKLSRLIEGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVEMLANKWFPNDDRVEAAYHIIQALEKR
Function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. Catalytic Activity: a beta-lactam + H2O = a substituted beta-amino acid Sequence Mass (Da): 41096 Sequence Length: 376 Subcellular Location: Periplasm EC: 3.5.2.6
P81073
MNQKHLLRFIKKSYRVDADRVVYDAK
Function: AMP deaminase plays a critical role in energy metabolism. Catalytic Activity: AMP + H(+) + H2O = IMP + NH4(+) Sequence Mass (Da): 3195 Sequence Length: 26 Pathway: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. EC: 3.5.4.6
P23109
MPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
Cofactor: Binds 1 zinc ion per subunit. Function: AMP deaminase plays a critical role in energy metabolism. Catalytic Activity: AMP + H(+) + H2O = IMP + NH4(+) Sequence Mass (Da): 86490 Sequence Length: 747 Pathway: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. EC: 3.5.4.6
P10759
MPLFKLTGQGKQIDDAMRSFAEKVFASEVKDEGGRHEISPFDVDEICPISLREMQAHIFHMENLSMSMDGRRKRRFQGRKTVNLSIPQSETSSTKLSHIEEFISSSPTYESVPDFQRVQITGDYASGVTVEDFEVVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEALVAIESFYPVFTPPPKKGEDPFRREDLPANLGYHLKMKGGVIYIYPDEAAASRDEPKPYPYPNLDDFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYHIDADRVVYSTKEKNLTLKELFAQLNMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVDAKYQHAEPRLSIYGRSPDEWSKLSSWFVGNRIYCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFLPVFEATINPQTHPDLSVFLKHITGFDSVDDESKHSGHMFSSKSPKPEEWTMENNPSYTYYAYYMYANIMVLNCLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADNISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKAKFLGNNYLEEGPVGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
Cofactor: Binds 1 zinc ion per subunit. Function: AMP deaminase plays a critical role in energy metabolism. Catalytic Activity: AMP + H(+) + H2O = IMP + NH4(+) Sequence Mass (Da): 86432 Sequence Length: 747 Pathway: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. EC: 3.5.4.6
P0A3Z3
MSNRRKNSLYPTLSAELSALMRTGWADTERHDLAPAEQAPYAALRRAALSARFPGERLVVPSGNLKVRSNDDTYPFRSYSGYVHMTGDQARDGALVLEPRPDGGHDAYCYQLPRDSRDDDEFWTGAHAELWTGRRRSLAESERVLGLPCRDVRTAAADLAAVSEVRTRIVRGIDPALEAAVTTDEERDAELEDALSDLRLVKDAWELGELRKAVDSTVRGFTDVVGELSRAVASSERWLEGTFFRRARLEGNAVGYGTICAAGEHATIMHWTDNDGPVRPGDLLLLDAGVETRSLYTADVTRTLPISGTFTPLQREVYDAVYEAQEAGIATVKPGAAYRDFHEAAQRHLAARLVEWGFIEGPAERAYELGLQRRFTMAGTGHMLGLDVHDCARARTEEYVEGVLEPGMCLTVEPGLYFQADDLTVPEEWRGIGVRIEDDLVVTEDGHENLSAGLPRSADEVEAWMARFAG
Cofactor: Binds 2 manganese ions per subunit. Catalytic Activity: Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Sequence Mass (Da): 51925 Sequence Length: 470 EC: 3.4.11.9
D5GHP2
MTSDSTVDKILAGKYPAKQHAENVVERLLHVHPDLTDGVIYLESQRSKLYENSDQEVPFRQRRYFYYLSGCDLADSYLTYSIRDRKLTLFIPPIDPASVLWSGLPLSNSEALEKYDVDEVLPTSATALPTTSYSSLMFVIESQTSRTFHLQNTESLEPAIERARAIKDEYEVALIKKANRISALAHHSCLRAIKSAGNEREIEAVFTKECIANGAPKQAYSGIFGSGRSASTLHYVHNNQPLAGKLNLLLDAGAEYNNYASDITRTFPISGQFTKESREVYDIVLDMQKQCLAASKAGAVWDDIHILAHKVAIQGLLKIGVLRNGSVDEILSNRTSTAFLPHGLGHYLGMDTHDCGGNPNYADPDPMFKYLRKRGPLPAGAVITVEPGIYFCEFIIKPYLEDEKHAKYIDKDVLNRYWDVGGVRIEDNILITEGGYENLTNVAKEVDDMLKFING
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides. Catalytic Activity: Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Sequence Mass (Da): 50793 Sequence Length: 455 EC: 3.4.11.9
C4JY72
MSGVAEPDCYLTYDITSDTLTLYVPDFDLRRAIWMGPTLGLAEARERYNIDQAKYRSTLEQDILDWASRRAIGSVIYVIHDNQKPVVPFPYLKFNHEDLIPAMDTCREIKDGHEIGLIRRANEISTSAHTEILRNISGMRNEAEIQGKFLDSCVSLGAKNQSYEIIAASGENAAVLHYTRNDEPLKGRQLVCLDAGAEWNCYASDVTRTFPMQPRWPSAEAFSVYSVVQRMQEECIKRISEGVRYLDLHILAHKIAIEELLRLGIFRGGSIAEILKSGASLVFFPHGLGHHVGLEVHDVSGRSLMALEEQEYQGLPLRGCRAPCTLSAPHLRAGMVVTVEPGIYFSRLALDDAKQKPLSKYIDMQLVAEYIPVGGVRIEDDVLVTRDGWENLTSAPKGRAMLDIIGEGARLRA
Cofactor: Binds 2 manganese ions per subunit. Function: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides. Catalytic Activity: Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Sequence Mass (Da): 46144 Sequence Length: 413 EC: 3.4.11.9
Q9AR04
MSLTEEKPIRPIANFPPSIWGDQFLIYEKQVEQGVEQIVNDLKKEVRQLLKEALDIPMKHANLLKLIDEIQRLGIPYHFEREIDHALQCIYETYGDNWNGDRSSLWFRLMRKQGYYVTCDVFNNYKDKNGAFKQSLANDVEGLLELYEATSMRVPGEIILEDALGFTRSRLSIMTKDAFSTNPALFTEIQRALKQPLWKRLPRIEAAQYIPFYQQQDSHNKTLLKLAKLEFNLLQSLHKEELSHVCKWWKAFDIKKNAPCLRDRIVECYFWGLGSGYEPQYSRARVFFTKAVAVITLIDDTYDAYGTYEELKIFTEAVERWSITCLDTLPEYMKPIYKLFMDTYTEMEEFLAKEGRTDLFNCGKEFVKEFVRNLMVEAKWANEGHIPTTEEHDPVVIITGGANLLTTTCYLGMSDIFTKESVEWAVSAPPLFRYSGILGRRLNDLMTHKAEQERKHSSSSLESYMKEYNVNEEYAQTLIYKEVEDVWKDINREYLTTKNIPRPLLMAVIYLCQFLEVQYAGKDNFTRMGDEYKHLIKSLLVYPMSI
Cofactor: Binds 3 Mg(2+) or Mn(2+) ions per subunit. Function: Involved in the biosynthesis of the antimalarial endoperoxide artemisinin . Catalyzes the formation of both olefinic and oxygenated sesquiterpenes, with amorpha-4,11-diene being the major product . Catalytic Activity: (2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate Sequence Mass (Da): 63933 Sequence Length: 546 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Pathway: Sesquiterpene biosynthesis. Subcellular Location: Cytoplasm EC: 4.2.3.24
Q46632
MKDISFSVVIPAYNASESIITTLDCLNEQSYKNFDVIIVDDKSADAQKLAEVVSSERYSGLKINLVLSETKLNGAGARNRGIDLATGDYVCFLDADDEWHKDKLQQNLSLIERLEGQGDRRFIIYSQVNIIQDGSFLKVMPLKPVGEHESIAEYLFGCYGFIQTSTIVLKREDAAEIRFDERYIRHQDYDLCIRADKLGFKFVMIAQPLANYHMVTRFGSQHKGESVKYSLFWLDAMKPHLTRRDVYTYKAYKLPLRYKMDGKSLQASLSFARYFFLTNKDNRNDFLKRLMNKLRTRLTGK
Function: Involved in the biosynthesis of amylovoran, which functions as a virulence factor. May function as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. Sequence Mass (Da): 34788 Sequence Length: 301 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. EC: 2.4.-.-
Q46633
MAIYWIVSYSILVFCFFELAMINQASEAKTKILINYFFLIGVFALILFAGIRGPDSGMDDSQYVGFFHDFSRQTGMTGYQAVANIYRYENFFMVLAWVASCFTHESYFFLLFISFIAVSTNAWVYKKYSPLILCSLCLYSAHLFINKDMNQIRFGLCSAFAIAFICSLVARNYLLALLFIVLSTQSHSTGYTIVMIIPFFFIRERKYLPLVLVIASIPLGIIGGKKLFLDSLGIVPVLGERAASYSGTNFDTTSPVFGLANLKNIAFIGAFTLYYFRKGIMKEDRFVYILLIAYSIGAAVRITFSDFSIFGGRVGNLFLHTEPLLFAFLMLRIRNLLLNFFMLFSITTYYLAYNTILSAQSIMGYSVAPLFRIFS
Function: Involved in the biosynthesis of amylovoran which functions as a virulence factor. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 42570 Sequence Length: 375 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. Subcellular Location: Cell membrane
Q46634
MYKLLILIDGISNSGGTDRVASTLSSLLSNHNYDVTLYSLNSGEPYYPVDNKVSIRQPKSSMRLFKLFEFIRYAKNTRPDGVMIISMGKLSVQALLLSKLFRVKSRLICCDHVSIETFSAAVRKLKVFCYGLAEKVVVLTQHDKNYLTSAFSLKNVYVVGNISPFHHENSLNRFDDVFARKQNRVLAVGRLTYQKNFGRLLDIWKNVHKQGWKLLIVGDGEEKAELLEKIKKYHLEESAEIVSPSKKISEYYRSSGVIAMTSRYEGLPMVLIEAKNYALPAIAFDCKTGPAEIIKDDGYVVDYQSNELFTAQLNQLIASEQLRKNFAQAAWQNSADYGPELILKKWNDILN
Function: Involved in the biosynthesis of amylovoran which functions as a virulence factor. May be involved in the formation of galactose alpha-1,6 linkages in amylovoran. Sequence Mass (Da): 39872 Sequence Length: 351 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. EC: 2.4.-.-
Q46635
MFSVLISLYNKEKPENLEQCLESLHQQTLNADEIVLVYDGPVSESLKAVATRWANLLPLVIVPLEKNLGLGKALNAGLERCTHNVVARMDTDDICLPERFEKQISYMESHPEVVLSGAAVIEFDEHGKERLKRLPLSNNDIHQFARMKNPFNHMCVVFRKDKVISAGSYQHHLYMEDYNLWLRIMSLGHPVANLPDVLMKVRAGSDMVNKRRGWNYIKSEVQLYRLKLALKQTGFIRGTLYFLIRTMTRLMPVKVMQFLYEKDRKG
Function: Involved in the biosynthesis of amylovoran which functions as a virulence factor. Sequence Mass (Da): 30747 Sequence Length: 266 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. EC: 2.4.-.-
Q46636
MKRRELIRTAFSTIVATAALSSVSARARSEDLHGLTLKKVPPDAIPKNDVPIFSPDDVFTMPEQFWRDFKGKLYIGKAGTDPTLPQNLIDVFVKNANGGTALLSQPIDLNSETLKTFVAAKGALWSASEYSMALHNDNDEQIFYVPDVKNNGVSEFSRRLSQPGGYQLIGEISSFASLRQTRPLFSGAKVRLKGWHDGTEVGGGAFVGEMTPSEDDGGYIASSGQDFHWRRVSDDMNRITLFDFGAVADGKKDCLPAVMAMYHWAQNNNQKLSIQFPAGRFFISSFDISAKYIRFLRLAGAPVNFGYFPATTLVSDGKSEFLFKVNARWVELSNISFEGQIEHSPNGQGFFHNICPAGQYFRGSCLRFTGVGGVSLSLIDTLDCKIDQWYASKCTGDVIRGSWSFTKKGNWDHNTAIELSNFNVQHCRQGKVLNLPRCTQSIIHNGWIEHSEFPGDLSNGQWIVDALSLEGCKNPLIAHCSRLNMRQTNLQSGSWIDNSLANDEWLSSFERGSTRVESYGIAVDGSMKYNYLTSRFRIENHSSQEKWYELGNIHTPDVGDSWEIEVFGQSQFSNGSGTKALMSVTDDRHTGGKAIINLQRKIHGFEASWSVEGSSPINDVVYTTSNDSDTRVFVKLAQWLGSAGVMIKTTAKDRFVTGHCARFDSRMVHSEPPKGEKVHSAVRRFSLHNGLAGIGANEQGDLLVESRHIDAAKVETSRAEGYISLVINGQQVAVPYFALKQNS
Function: Involved in the biosynthesis of amylovoran which functions as a virulence factor. May be involved in the polymerization or late modification of the repeating units. Sequence Mass (Da): 82253 Sequence Length: 743 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. Subcellular Location: Periplasm
Q46628
MREIEFTFKGLLIRLSLALSDLIFFNIALALAIVLINGFPGEILTGIPQHELDLKIATHILLSVICVGWFWVRLRHYTYRKPFWFELKEVFRTILIFSIVDLSVSALSKWELSRWIWILTWLLSMAMVPFGRACVKRLLNRKKLWKKQSIIIGSGKNAQEAWQALQSEEMMGFDVIAFYDVDGSQTALELFGVPVLKEEQQLWSLVDSDTQFIVAVEYEQSQSRDRWLKNLATHNCRSVSVIPSLRGVPLYGTDMAYIFSHEVMILRVSNNLAKHSSRFLKRTFDLVGALSIITLLLPALVILIFMVSRDGGAPIYGHERVGRDGRKFKCLKFRSMVVNSKEVLEEVLRTDPVARAEWDEDFKLKNDPRITRIGHFIRKTSLDELPQLWNVVRGEMSLVGPRPVIEAELERYAGDVDYYFMAKPGMTGLWQVSGRNDVSYETRVYFDSWYVKNWSLWNDIAILFKTIGVVLKRDGAY
Function: Involved in the biosynthesis of amylovoran which functions as a virulence factor. May act as a sugar transferase and may be involved in the export of the repeating unit by flipping the lipid carrier to the periplasmic face of the inner membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55074 Sequence Length: 477 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. Subcellular Location: Cell membrane EC: 2.-.-.-
Q8VYB5
MGSSFETIDIATSARRIGVDNRISLKFYFRIADNILKQANIFRAEKNVIDLYVMLLRFSSLALETIPSHRDYRTSLKSNKEYLRMRLLDVLTELEKLKPVVQQRIDELYPKLKPRYNVQAHPANGSLGWSSAVKPSFNSYDHAKVRNPPGHNSGYMGSRGQQFLNAAPLEERFRKMSVNFRPNEETLSKHSILGPGGLSAQWQPPKYDTKVQYPSNIDFSPVVIPSFQQLVDSKPMITNGSNDEPEKPIVEPSVASNEKIQKNYTEELSSMISFEEPESVNENNLIRQPSPPPVLAEVQDLVPALCPEVREPECMIENSLPDESLRSESPLELHIATSMMDTFMRLAKSNTKKNLETCGILAGSLKNRKFYITALIIPKQESTSDSCQATNEEEIFEVQDKQSLFPLGWIHTHPTQSCFMSSIDVHTHYSYQIMLPEAVAIVMAPQDSSRNHGIFRLTTPGGMTVIRNCDRRGFHAHSSPEDGGPIYNTCKEVYMNPNLKFDVIDLR
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: Zinc metalloprotease that cleaves 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Location Topology: Peripheral membrane protein Sequence Mass (Da): 57383 Sequence Length: 507 Domain: The JAMM motif is essential for the protease activity. Subcellular Location: Membrane EC: 3.4.19.-
Q6NKP9
MVTLSSPSPSLSCVENVTCKSSHVSRVLISGTDNINHGESSEAKILRDVHISERLLEDFTELARENTEKDLETCGTLAAFLERGIFYVTTLIIPKQESTSNSCQAMNEVEVFSIQNERELYPVGWIHTHPSQGCFMSSVDLHTHYSYQVMVPEAFAIVVAPTDSSKSYGIFKLTDPGGMEVLRGCSETGFHPHKEPEDGNPVYEHCSNVYKNSNLRFEIFDLR
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: Zinc metalloprotease that cleaves 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Sequence Mass (Da): 24939 Sequence Length: 223 Domain: The JAMM motif is essential for the protease activity. EC: 3.4.19.-
Q5PNU3
MKIDLNKVAREIEVDNRIPLRNYYRIADNLLRQASIYREEKNVVDLYIMLLRYSSLISETIPFHRDYQASLPQERLGSRKRLRAVINELESLKPEFNQLVDKLNRVEDESRQDGSDLPVVSYSSDAVEWPPAHKASYSRPDINKPLPTSQPSWTYNNNLTSSSNRTQIDQQFQKLSFDFLPPNQATLSRHSFLGPNGLKRQMVAPKSEIKVQYPSNTDWGSADNSGLIEAGPSSSSASLNGDSQEVSTLNSVLSLDDGRWQRHSEAVNSQFISDATEDPFQFVGMKQPSPPPVLAQVHQELAQICPSKVADPRPGPAIPSLEGKEGSNSYQHLHVPVRIMDDFLRLARSNTERNLETCGVLAGSLKNRVFHITTLIIPKQESTSDSCQTLNEEEIFEVQDRLSLFPLGWIHTHPTQTCFMSSVDLHTHYSYQIMLPEAVAIVMAPTDESTPHGIFHLSDPSGVSVIRNCQQRGFHPHEESEDGNPIYEHCSHVFLNAKLKYEVLDLR
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: Zinc metalloprotease that cleaves 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, but is not implicated in protein degradation by the 26S proteasome, deneddylation, or desumoylation. Required for intracellular trafficking (e.g. trafficking from the Golgi to the vacuole and the vacuolar trafficking of endocytosed cargo), endocytosis and vacuole biogenesis. Location Topology: Peripheral membrane protein Sequence Mass (Da): 57268 Sequence Length: 507 Domain: The JAMM motif is essential for the protease activity. Subcellular Location: Membrane EC: 3.4.19.-
Q46630
MINSILVVCIGNICRSPTGERLLKAALPERKIASAGLKAMVGGSADETASIVANEHGVSLQDHVAQQLTADMCRDSDLILVMEKKHIDLVCRINPSVRGKTMLFGHWINQQEIADPYKKSRDAFEAVYGVLENAAQKWVNALSR
Function: May function as a phosphatase required for amylovoran (an exopolysaccharide that functions as a virulence factor) production. Catalytic Activity: H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Sequence Mass (Da): 15772 Sequence Length: 144 EC: 3.1.3.48
Q46637
MKILLVGNHTCGNRGDGAILRGIIDSLHLERTDLDIDIISRFPTSSSYLLQQNILPDELFLETKKSNSLVAKVKRRLMPKIMMAHIRGSGFFKNLAVPEYLQQFTDKLKQYDAVIQVGGSFFVDLYGPLQFEHSLCALLAKKPVYMIGHSVGPFQKERFNQIANFVFSRVNSLVLRESVSLEMMEKAGITTQKVIPGADTAFLVRTRTLDAPGHNLIHWQNQIAASKTIAITVRELAPFDKRLGVTQQEYEMAFGKVINAMIERGYQVVALSTCTGIDSYHRDDRMVAITLGDYVQQKDKYRVVMDEFNDLELGILLAGCHLTIGTRLHSAIISMNFGTPAVAINYEHKSLGVMKQLGLPEMASDVQSLMDGSIIAKVNGVLDNYEEIEQQVARAVEQERILGNKITADVLKSIG
Function: Involved in the biosynthesis of amylovoran which functions as a virulence factor. Sequence Mass (Da): 46292 Sequence Length: 415 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. EC: 2.-.-.-
Q46639
MSSYIVHRQNITRKEQSTIYWVNVLLSMLTGLLLVAIAWPISWFYHLPQLGGLIMLTSLNFLVLGSLSQYQAHFIKAKRMILLAKIEMVTKFLAFAFTVILLYYSPLGVSAVILGLFANAALRIGCMIWFGDKSWRPTFEFDQGTFYSSLKYGIYQLGSQTINQLRTQADSLIVGKVMGAELLGVYSLAKELILQPLKLVTPVINRLALPRFAEKQHDPVRLQQLFLKGTFVIMLFSAIMYLAIGILSPVIVRVLYGPAHEAVGQLIPLMLLFGMLRPMGGLTGAISQANGRTNVEFYWNVVASIIVVLVLASVWIWPQVEYVALTLSISQVLISVFAHPFFIKPVIGIRFLPYARQWISVSAVFVGIIALVSHYNLFIMPEWFSRWL
Function: Involved in the biosynthesis of amylovoran which functions as a virulence factor. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43726 Sequence Length: 388 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. Subcellular Location: Cell membrane
C9K7C1
MYCDKGASSLANGLLPNVSGDITAKDNILDALDSSAEEHFWGRYIDGFEGQIFPQIPVSVHEAHLTGRARYEIILGNSMVTTLYTVSSIIRTGWALLVSQYTESQDVVIVSSLELPSQAMGGTILFPIRFRIRQDGRTEELLQSAKKHADKVLSSQKHDFPHTKDFVDPFSNSILLICTESQPSHSLEELLTELSASKKCALVLRCELLEDKISISAMFDPQVVRPRQTRRILDQLGHILKQISGSDMLVGDLDFLSPEDRQEIGRWNSRSALSDECIHALISKQAQQNPAAMAVNAHDGNFTYGELESYATRLAAHLIHIGVKPGNFVPTLFEKSKWTQVGILAILKAGAAFVMLDPSHPPARNQLICRKANACFALASAPCEPVLSMAVPHVITLSHSFMEELGRLQPPHEQKSPCLDPRAVAYLLFTSGSTGQPKGAILEHRSFAAASRGVVAMTHMSSTTRTLQHSSYSFGAAIVEIIATLVAGGCVVVLSDTERLSNVAASMVAYSVNWAFMTPSFARTVNPADVPCLRVLATGGEGVTSDIVETWASFVSLYTVYGSAEQSSIAAMAGPLATHQRGNSANVGSPFAGCYAWIVQPDRPEKLAPVGCVGELVLEGALVARGYIDEVESTAAAFPKGFSWRCLFPLHQEGSTRFYRTGDLVRYAVDGTLEFVARRNGYIKLRGQRIELGEIESQLKAVARQPYEFCVEVVVPKGETADKAVLVAFVALGSAYTDNEICESAISSPEQFDQGILVDVLGHVEERLAETLPAFMIPRFFFPLQHFPVTSSGKIARKILREQAAQMSVLQLAELSLGSVEKKELQSDMERYLRSVWVQLLGVPEDFIGANDSFFRVGGDSLKAIKLFQRLRRDGYNLNVTSIVAAPTLSQMARNCSLLD
Function: Nonribosomal peptide synthetase; part of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease (Probable). AM-toxins are cyclic depsipeptides containing the 3 residues 2-hydroxy-isovaleric acid (2-HIV), dehydroalanine, L-alanine which are common for all 3 AM-toxins I to III. The fourth precursor is L-alpha-amino-methoxyphenyl-valeric acid (L-Amv) for AM-toxin I, L-alpha-amino-phenyl-valeric acid (L-Apv) for AM-toxin II, and L-alpha-amino-hydroxyphenyl-valeric acid (L-Ahv) for AM-toxin III (Probable). AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss and chloroplast disorganization . The non-ribosomal peptide synthetase AMT1 contains 4 catalytic modules and is responsible for activation of each residue in AM-toxin . The aldo-keto reductase AMT2 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV), one of the precursor residues incorporated by AMT1 during AM-toxin biosynthesis, by reduction of its ketone to an alcohol . The cytochrome P450 monooxygenase AMT3 and the thioesterase AMT4 are also important for AM-toxin production, but their exact function within the AM-toxin biosynthesis are not known yet . Up to 21 proteins (including AMT1 to AMT4) are predicted to be involved in AM-toxin biosynthesis since their expression ishighly up-regulated in AM-toxin-producing cultures . Sequence Mass (Da): 98347 Sequence Length: 900 Domain: NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase (By similarity). AMT10 is composed of only one module and misses a condensation (C) domain (Probable). Pathway: Mycotoxin biosynthesis. EC: 6.3.2.-
P37730
MAKKAKFFKNGIWYWLFIAPTLLSLIIVVLIPFIIGIYYSFTDWNGINQPVFIGLKNFMTLRDDAEFWNSIIFTAKFAVACIVIINVVGLSLAMLVTRKIFARNFMRTAFYLPNLIGGLILGFIWNFIFVDVFQTISDATHIGWLGGWLSTTNTGFWGLVIVTSWQMIGYVMVIYIAYIESIPTDLIEASKIDGANSWQQFRNVVFPLIAPAFTVSLFITLSNSFKLFDQNLSLTAGAPGNTTQMITLNIYQTAFSAQEMAVGQAKAVIMFLIIAVISVIQVYLTQKREVEM
Function: Probably part of a binding-protein-dependent transport system starch degradation products. Probably responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32908 Sequence Length: 292 Subcellular Location: Cell membrane
Q03045
MRLLPSSCAGALSLLCSLAIAAPTELKARDLSSFIASERAIALQGALNNIGPDGSAVPGAGAGFVVASPSKANPDYFYTWSRDSALTLKMIIDEFILGNTTLQTIIEQYIHAQAVLQTVSNPSGTFLPDGVGLGEPKFMVDGTRFNGPWGRPQRDGPALRAIALMTYSNWLIKNGQFAEAKTKIWPIIANDLSYVGQYWNQSGFDLWEETYASSFFTIQNQHRALVEGAQLAHDLGVTCTGCDQAPEVLCFLQSFWNGKYIVSNINVNNGRTGLDGNSILGAISTFDIDAYCDSPTLQPCHSQSLANFKVLTDTFRNLYTINAGIPEGQGVAVGRYAEDVYMGGNPWYLITTAAAEFLYDAVAQWKARHVLTVDETSLAFFKDIYPEVTVREYKSGNANSPFAQIMDAVTAYADSYVAIAEKYIPSNGSLSEQFNRDTGTPLSAIDLTWSYAAFITMSQRRAGQYPSSWGSRNALPPPTTCSASSTPGIYTPATAAGAPNVTSSCQVSITFNINATTYYGENLYVIGNSSDLGAWNIADAYPLSASAYTQDRPLWSAAIPLNAGEVISYQYVRQEDCDQPYIYETVNRTLTVPACGGAAVTTDDAWMGPVGSSGNC
Catalytic Activity: Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. Sequence Mass (Da): 66432 Sequence Length: 616 Subcellular Location: Secreted EC: 3.2.1.3
O74254
MKLLSKVFVTALGLTSIVNAAPTSSSSAEEAQKTVPVELSIGVKQLPNIHNDSAVDANAVAKGYSLVNVSLTARGLTGILKLKEATNIYGYDFEYLNLSVEYQSDTRLNVHIEPTDLTDVFVLPEELVVKPKLEGDAKTFNFENSDLVFEYDEEDFGFEVLRSSTREVLFSTKGNPLVFSNQFIQFNTTLPKGHSITGLGESIHGSLNEPGVVKTLYANDIADPIDGNIYGVHPVYYDQRYNTNTTHAVYWRTSAIQEVVVGETSLTWRALSGVIDLYFFSGPDPKDVIQQYVSEIGLPAMQPYWALGYHQCRWGYDTVESLETVVENFKKFDIPLETIWSDIDYMDGYKDFTNDPYRFPTDKFRKFLDDLHNNSQHYVPIFDAAIYVPNPNNATDNDYEPFHLGNESDVFLKNPDGSLYIGAVWPGYTVFPDFLANNTQEYWNKMFKDWYERIPFDGIWTDMNEVSSFCVGSCGTGRYFDNPVHPPFEVGYSGSDYPLGFDKSNASEWKSISEAAAATKTTTTTSSSTSTSIDGKNTLAPGKGNINYPPYAINNNQGDHDLATHAISPNATHADGTVEYDIHNIYGLIQERAIYEALLEIHPNKRPFIIGRSSFAGSGKYMGHWGGDNYADYYMMYFSIPQALSMGLSGIPFFGVDACGFNGNTDMELCSRWMQLASFFPFYRNHNVLGAIPQEPYVWEGVMNATKTSINVRYSLLPYYYTLLHESHVTGIPIMRAFNWQFPYSKELAGVDTQFFVGDALLVTPVLEPGVNHTKGVFPGENAVYYDFYTHKKQKFTAGKNETLAAPLGHIPLHIKGGNIIPTQEPGYTTTESRKNPFGLLVALDAEGTASGKLYLDDGESVDVEEALYVDFVASKNKLVASVFGEYEVRQPLANVTILGVDSEPKKVLFNNETVSHNYENGAVYLTDLEKFTKEGAFAEEFSIQW
PTM: The N-terminus is blocked. Location Topology: Peripheral membrane protein Catalytic Activity: Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. Sequence Mass (Da): 105717 Sequence Length: 946 Subcellular Location: Secreted EC: 3.2.1.3
P29761
MSRKLIKYLPLLVLASSVLSGCSNNVSSIKIDRFNNISAVNGPGEEDTWASAQKQGVGTANNYVSKVWFTLANGAISEVYYPTIDTADVKEIKFIVTDGKSFVSDETKDTISKVEKFTDKSLGYKLVNTDKKGRYRITKEIFTDVKRNSLIMKAKFEALEGSIHDYKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDNVYTALSSNIGWKGYSIGYYKVNDIMTDLDENKQMTKHYDSARGNIIEGAEIDLKKNSQFEIVLSFGNSEDEAVKASIETLSENYDSLKSAYIDEWEKYCNSLNNFNGKANSLYYNSMMILKASEDKTNKGAYIASLSIPWGDGQGDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGMIPQNTWISGKPYWTGIQLDEQADPIILSYRLRRYDLYDSLVKPLADFIIKMGPKTGQERWEEIGGYSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTEHGPLENGQYYIRIAGLPDPNADFTISIANGGGVYDQKEIVDPSFLELVRLGVKSPDDPKILNTLRVVDSTIKVDTPKGPSWYRYNHDGYGEPSKTELYHGAGKGRLWPLLTGERGMYEIAAGKDATPYLKAMENFANEGGIISEQVWEDTGLPTDSASPLNWAHAEYVVLFPSNIEHKVLDMPDIVYKRYVAK
Function: CGA has typical kinetic properties for a glucoamylase, but this bacterial enzyme had higher isomaltose-hydrolyzing activity than other eukaryotic glucoamylases. Catalytic Activity: Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. Location Topology: Lipid-anchor Sequence Mass (Da): 78658 Sequence Length: 702 Subcellular Location: Cell membrane EC: 3.2.1.3
D8Q9M3
MGLASTVSLALLGLCSLARAQTSAADAYVSAESPIAQAGILANIGPSGSKSHGAASGVIIASPSTSNPDYLYTWTRDAALVSRALVDEFIEGESSLQSVIDSYVSSQQKLQRVDNPSGSYTSGGLGEPKFNIDLTAFTGAWGRPQRDGPALRAITLITYGNHLLSSGNTSYVTDTIWPVVKADLDYVVSYWNQTGFDLWEEVSSSSFFTTAEQHTALRLGATFATAVGASASTYLTQADNVLCFLQSYWNSNGGYATANTGGGRSGIDANTVLTSIHTFDIEAGCDSVTFQPCSDRALSNLKVYVDSFRGLYSINPTGATDPILTGRYKEDVYYNGNPWYLTTFAVAEQLYDALNTWDKLGSLDVTSTSLAFFKQFDSSITAGTYASSTSEYATLTSAIRNWADGFLEVLADFTPADGGLTEQIDKSSGNPTSAADLTWSYASAITAFKARGGAIPASWGAAGLTVPATCSTGGGGGSGGDTVAVTLNVQATTVYGENIYVTGSVNQLANWSPDNAIALNADNYPTWSVTVNLPANTQIEYKYIRKNNGQVTWESDPNRSITTSASGSFTQNDTWR
Catalytic Activity: Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. Sequence Mass (Da): 60941 Sequence Length: 576 Subcellular Location: Secreted EC: 3.2.1.3
A1DN11
MTVTISFEPYVGSSVDALSIPLYLRCQLVFKLSKPLAAVPLLESGVNRLVQALPFLSGEFTAVPASDGGKEILLVRPVLNFELSRILKIKYHETSLRHVCKQMNRPSSQGGDLPHEPYMPYPRLPDPSRPQPIVGFQVNVHTDGIILSVATHHCSFDATGMGSIVQNLAACCRSPPSDEPDLTTSPAQEAEARKVLSQVRETPFDPKMFPEYRPLDSMLSYYKGVQSALQGRQTTIVNRCFTIAADKINALKRRCNQLIPEMVKKYGLSTEDAIGSAWVSSNDVVAALLWTCINRARYPEIRERSVHQLPPDLLHATSSLGVPVNVRSRLSPPLPKSTLGNAVCLLREKVPLQFFALPSHANMEATSSVCADHSGDDEWALSFCRVAYGLRAKLNAIDDDYIRDYISYVQKSPCHLSVTLDTENLYLSNWREIGVYDADFGGMLGKPLRMRAPDGYTDGLIFVMAQRSEDKSAPWEFNISLEASTMKRIVHDPLWCKYVELDAFWHGEE
Function: O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of the prenylated pyrroloindoline diketopiperazine acetylaszonalenin . The first step in the pathway is the formation of (R)-benzodiazepinedione by condensation of tryptophan and anthranilic acid catalyzed by the non-ribosomal peptide synthetase anaPS . The prenyltransferase anaPT then converts (R)-benzodiazepinedione to aszonalenin in the presence of dimethylallyl diphosphate (DMAPP) via C3-prenylation . The last step in the biosynthesis of acetylaszonalenin via acetylation of aszonalenin at position N1 catalyzed by anaAT . Catalytic Activity: (2R,3S,11R)-aszonalenin + acetyl-CoA = (2R,3S,11R)-acetylaszonalenin + CoA Sequence Mass (Da): 56729 Sequence Length: 509 Pathway: Alkaloid biosynthesis. EC: 2.3.1.-
P54802
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPRWVAGSW
Function: Involved in the degradation of heparan sulfate. Catalytic Activity: Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Sequence Mass (Da): 82266 Sequence Length: 743 Subcellular Location: Lysosome EC: 3.2.1.50
P80884
MTSKVQLVFLFLFLCVMWASPSAASCDEPSDPMMKQFEEWMAEYGRVYKDNDEKMLRFQIFKNNVNHIETFNNRNGNSYTLGINQFTDMTNNEFVAQYTGLSLPLNIKREPVVSFDDVDISSVPQSIDWRDSGAVTSVKNQGRCGSCWAFASIATVESIYKIKRGNLVSLSEQQVLDCAVSYGCKGGWINKAYSFIISNKGVASAAIYPYKAAKGTCKTNGVPNSAYITRYTYVQRNNERNMMYAVSNQPIAAALDASGNFQHYKRGVFTGPCGTRLNHAIVIIGYGQDSSGKKFWIVRNSWGAGWGEGGYIRLARDVSSSFGLCGIAMDPLYPTLQSGPSVEVI
Function: Cysteine protease . Displays a high level of diversity in substrate specificity at the P1-P1' cleavage site . A hydrophilic P1 residue is preferred, with Gln or Arg strongly preferred . Favors an Ile/Leu residue at the P2 position of substrates, with an overall higher preference for Leu . The optimal tripeptide for cleavage is Pro-Leu-Gln, with cleavage occurring after the Gln residue . Another optimal tripeptide is Val-Leu-Arg, which may imply that a hydrophobic residue at the P3 position of substrates is preferred . Catalytic Activity: Hydrolysis of proteins with broad specificity for peptide bonds. Best reported small molecule substrate Bz-Phe-Val-Arg-|-NHMec, but broader specificity than fruit bromelain. Sequence Mass (Da): 38248 Sequence Length: 345 EC: 3.4.22.31
A1DN10
MSPLSMQTDSVQGTAENKSLETNGTSNDQQLPWKVLGKSLGLPTIEQEQYWLNTAPYFNNLLIQCGYDVHQQYQYLAFYHRHVLPVLGPFIRSSAEANYISGFSAEGYPMELSVNYQASKATVRLGCEPVGEFAGTSQDPMNQFMTREVLGRLSRLDPTFDLRLFDYFDSQFSLTTSEANLAASKLIKQRRQSKVIAFDLKDGAIIPKAYFFLKGKSLASGIPVQDVAFNAIESIAPKQIESPLRVLRTFVTKLFSKPTVTSDVFILAVDCIVPEKSRIKLYVADSQLSLATLREFWTLGGSVTDSATMKGLEIAEELWRILQYDDAVCSHSNMDQLPLVVNYELSSGSATPKPQLYLPLHGRNDEAMANALTKFWDYLGWKGLAAQYKKDLYANNPCRNLAETTTVQRWVAFSYTESGGAYLTVYFHAVGGMKGNL
Function: Indole diterpene prenyltransferase; part of the gene cluster that mediates the biosynthesis of the prenylated pyrroloindoline diketopiperazine acetylaszonalenin . The first step in the pathway is the formation of (R)-benzodiazepinedione by condensation of tryptophan and anthranilic acid catalyzed by the non-ribosomal peptide synthetase anaPS . The prenyltransferase anaPT then converts (R)-benzodiazepinedione to aszonalenin in the presence of dimethylallyl diphosphate (DMAPP) via C3-prenylation . The last step in the biosynthesis of acetylaszonalenin via acetylation of aszonalenin at position N1 catalyzed by anaAT . Catalytic Activity: (R)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11R)-aszonalenin + diphosphate Sequence Mass (Da): 48811 Sequence Length: 437 Pathway: Alkaloid biosynthesis. EC: 2.5.1.-
Q96K21
MNYDSQQPPLPPLPYAGCRRASGFPALGRGGTVPVGVWGGAGQGREGRSWGEGPRGPGLGRRDLSSADPAVLGATMESRCYGCAVKFTLFKKEYGCKNCGRAFCSGCLSFSAAVPRTGNTQQKVCKQCHEVLTRGSSANASKWSPPQNYKKRVAALEAKQKPSTSQSQGLTRQDQMIAERLARLRQENKPKLVPSQAEIEARLAALKDERQGSIPSTQEMEARLAALQGRVLPSQTPQPAHHTPDTRTQAQQTQDLLTQLAAEVAIDESWKGGGPAASLQNDLNQGGPGSTNSKRQANWSLEEEKSRLLAEAALELREENTRQERILALAKRLAMLRGQDPERVTLQDYRLPDSDDDEDEETAIQRVLQQLTEEASLDEASGFNIPAEQASRPWTQPRGAEPEAQDVDPRPEAEEEELPWCCICNEDATLRCAGCDGDLFCARCFREGHDAFELKEHQTSAYSPPRAGQEH
Function: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. PTM: Phosphorylated in vitro at Ser-22 by AURKB; however, phosphorylation at this site could not be confirmed in vivo. Sequence Mass (Da): 51546 Sequence Length: 471 Domain: The FYVE-type zinc finger mediates binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). Subcellular Location: Cytoplasm
Q9DAZ9
MESRCYGCAVKFTLFKKEYGCKNCGRAFCNGCLSFSALVPRAGNTQQKVCKQCHTILTRGSSDNASKWSPPQNYKKRVAALEAKKKSSTSHSQSLTHKDQAIAERLARLRQENKPKSVPSQAEIEARLAALKDEVQGPIPSTQEMEDRLAALQGRVPPSHTVRPAHQAPDTRTQAQQTQDLLTQLTAEVAIDENCQPRASASLQNDLNKGAARSQRTNSQGQASQSLEEEKYKLLAEAAVELQEENTRQERILALAKRLAVLKGQDPSRVTLQDYHLPDSDEDEETAIQRVMQQLTEEAALDEASGFNIPEKPAPGSRAQPCKAEMEGPQAEEEELPWCCICNEDATLRCAGCDGDLYCARCFREGHDNFDLKEHQTSPYHPRRPCQEH
Function: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity). Sequence Mass (Da): 43272 Sequence Length: 389 Domain: The FYVE-type zinc finger mediates binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). Subcellular Location: Cytoplasm
Q84BZ0
MSADPFVIVGAGHAARRTAEALRARDADAPIVMIGAERELPYDRPALSKDALLNDDGEQRAFVRDAAWYDAQRIALRLGTRVDAIEREAQRVRLDDGTTLPYAKLVLATGSRVRTFGGPIDAGVVAHYVRTVADARALRAQLVRGRRVAVLGGGFIGLEVAAAARQLGCNVTVIDPAARLLQRALPEVVGAYAHRLHDERGVGFQMATLPRAIRAAAGGGAIVETDRGDVHADVVVVGIGVLPNVELAQAAGLDVDNGIRVDAGCRTADRAIFAAGEVTMHFNPLLGRHVRIESWQVAENQPAVAAANLLGADDAYAELPWLWSDQYDCNLQMLGLFGAGQTTVVRGDPARGPFTVFGLGGDGRIVAAAAVNLGRDIGAARRLIAAGAMPDPQQLADPTVGLKTFL
Function: Part of the multicomponent anthranilate dioxygenase, that converts anthranilate to catechol. Probably transfers electrons from ferredoxin (AndAb) to NADH. Catalytic Activity: H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 42869 Sequence Length: 406 Pathway: Aromatic compound metabolism; anthranilate degradation via hydroxylation; catechol from anthranilate: step 1/1. EC: 1.18.1.3
Q9BQD7
MEQDDPVEALTELRERRLGALELLQAAAGSGLAAYAVWALLLQPGFRRVPLRLQVPYVGASARQVEHVLSLLRGRPGKTVDLGSGDGRIVLAAHRCGLRPAVGYELNPWLVALARLHAWRAGCAGSVCYRRKDLWKVSLRDCRNVSVFLAPSVLPLLEDKLRTELPAGARVVSGRFPLPTWQPVTAVGEGLDRVWAYDVPEGGQAGEAASSRIPIQAAPGPSSAPIPGGLISQAS
Function: Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration . Probably also trimethylates ANT1/SLC25A4 . Catalytic Activity: L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine Location Topology: Single-pass membrane protein Sequence Mass (Da): 25130 Sequence Length: 235 Domain: The pre-methyltransferase (preMT) region is responsible for mitochondrial localization. Subcellular Location: Mitochondrion membrane EC: 2.1.1.-
Q501J2
MDQDDPAEALTELREKRLGLLEIVQAAAGSGLAVYTIWALLLQPGFRRVPLRLQVPYVGASARQVENVLSLLRGRPGKMVDLGSGDGRIVLAAHQCGLRPAMGYELNPWLVGLARLHAWRAGCSASVCYHRKDLWKVSLRDCHNVSVFLAPSVLQLLEDKLQAELPVGARVVSGRFPLPTWQPVAVVGEGTDRVWAYDVHGSGPTVSSCGVPIKAIPESSSTLVPRAPV
Function: Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. Catalytic Activity: L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine Location Topology: Single-pass membrane protein Sequence Mass (Da): 24740 Sequence Length: 229 Domain: The pre-methyltransferase (preMT) region is responsible for mitochondrial localization. Subcellular Location: Mitochondrion membrane EC: 2.1.1.-
Q9GZV1
MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
Function: Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. PTM: Phosphorylation at Ser-99 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation. Sequence Mass (Da): 39859 Sequence Length: 360 Subcellular Location: Cytoplasm
Q9WV06
MEGPEAVQRATELIEQRLAQEEETEKLRRSAPGKLSMDMLVLEEEKRLGVQSPALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAAQEPPPEPEEITGPVNEETFLKAAVEGKMKVIDKYLADGGSADTCDEFRRTALHRASLEGHMEILEKLLENGATVDFQDRLDCTAMHWACRGGHLEVVRLLQSRGADTNVRDKLLSTPLHVAVRTGHVEIVEHFLSLGLDINAKDREGDSALHDAVRLNRYKIIKLLLLHGADMMAKNLAGKTPTDLVQLWQADTRHALEHPEPESEQNGLERPGSGRETPQPIPAQ
Function: Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. PTM: Phosphorylation at Ser-68 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation. Sequence Mass (Da): 36707 Sequence Length: 328 Subcellular Location: Cytoplasm
Q96BM1
MPWDARRPGGGADGGPEASGAARSRAQKQCRKSSFAFYQAVRDLLPVWLLEDMRASEAFHWDERGRAAAYSPSEALLYALVHDHQAYAHYLLATFPRRALAPPSAGFRCCAAPGPHVALAVRYNRVGILRRILRTLRDFPAEERARVLDRRGCSRVEGGGTSLHVACELARPECLFLLLGHGASPGLRDGGGLTPLELLLRQLGRDAGATPSAAGAPASAPGEPRQRRLLLLDLLALYTPVGAAGSARQELLGDRPRWQRLLGEDKFQWLAGLAPPSLFARAMQVLVTAISPGRFPEALDELPLPPFLQPLDLTGKG
Function: Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly . Implicated in different cellular processes, like copper homeostasis and cell proliferation . Sequence Mass (Da): 34295 Sequence Length: 317 Pathway: Protein modification; protein ubiquitination. Subcellular Location: Cytoplasmic vesicle
C5BV64
MRVLGMISGTSHDGIDVAVVRFTLDAGGAQLRGVVEHATTVPYPTALRARVAGALPPAQVGMAEVCALDADLGHAFADAAAEAAAAPDVPEPPDLVCSHGQTMYHWVAEGSALGTLQLGSPAWIAERLGVPVVADVRIRDVTAGGQGAPLVPLLDELLLAGASGRTAVLNLGGIANVTVVGDGADPVAYDVGPANALIDAAVAAAGRGAYDADGALAAAGRVHAPLLDALLTEPYYARRPPKSTGKELFDPGYVDRVRRGAGGAAAADLSLEDLVSTLTELTARVVAQDVRRLDVARLVVSGGGVRNPVLLGALTAAVPGVEVVPSDAFGVSVDHKEAVAFALLGWFTAHGLPASVPSATGASGARVLGSVTPGAGPLRLPTPLSTAPSRLRLTS
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 39695 Sequence Length: 395 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q7VUW3
MDSTTHGPRTHVPGRLFIGLMSGTSMDGADGVLVRLDGPRPEVLASASLPMPAALRDELFALNHAGANELERAALAANGLARLYARAVRQLLDQAGLQPGDVAAIGAHGQTVRHRPDLGYTLQLNAPALLAELAGIDVVADFRSRDVAAGGQGAPLVPPFHAALFAGGQARAVLNLGGIANVTLLEPGRPPRGFDTGPANVLLDAWCQRHTGQPYDADGRFAAQGQVLADLLEHLIASEPWFALAPPKSTGRDLFNLDWLLARLQAFDGPAPQPQDVQATLQRLTARTVANAIDASAAAPRDVLVCGGGARNPGLMRELAYCLQRPVRPTDDAGVPAQWVEALAFAWLAQACLDRIPAGLPTVTGARAARVLGALYPA
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 39576 Sequence Length: 378 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
A6X3N5
MQPIWAVGLMTGTVLDGNIDVALLKTDGETIAEFGAYALKPYPRWIRDLLEQAQAEARVWNFEGAEPAIFAEAEEALTRAQSAAVRELVEESGLSMADIGVVGFHGQTVLHRAPQAGRLGDTRQLGDGRLMSQLLATKVAYDFRTADIRAGGQGAPLAAVYHAALLRSADASGNTAILNLGGVGNITWWDGDDALVAFDTGPANAPINDFMKKRGLGEMDRDGALAAKGKVDEDRLAELLKHPYLIAPYPKSLDRFDFTEMMADGLNEENGAATLTAFTTSAVGKALDILPRRPKRLAVSGGGRRNPTMMHMLVERAEVELVPVEALGWRGDAVEAECFAFLAVRVLRGLPISFPSTTGVPEPMTGGELVG
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 39683 Sequence Length: 371 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q46HU0
MRVLGLMSGTSADGIDAVLVDFTGDPSRPKWQILNTFSYEYPSSIREKIIQVGQGLKISSKDWLELAEEITELNAFAARTCDPDSTAEVVGCHGQTLFHRSVKKSKRGGSLQILLGPLLANLLDQIVIYDFRSKDIASGGHGAPLVALVDEALVGRLYGWRGVLNLGGIANLTIIPPKTGIDKTSQCLGWDCGPANSLVDLAVKESTNSSLTFDENGSLASLGIPKLEIIDKWLRDPFFYLEPPRSTGREQFGFQYLQKRKKELGDISKEDLISTLTTFTASIISQDLDNLFKLKQIRLIELLVAGGGSKNLFLMRQLQKQCCGVHVRPIHEIGVPSQYREALVFATLSWWNFLGKKVHPKYITGANKPILYGVRVDP
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 41702 Sequence Length: 378 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q15RS7
MNKHIEQLYRSAKKRSRLIIGLMSGTSLDGLDVALCRIEGHGTDTQIELVAFCTVDYDDGYKQKIKSVFAKRQVDLQQVTLLNPWVGVLHGQMVNQCLEKWNIAATDIDAIASHGQTIYHCPLGQHGQSEFGNATLQIGDADHLAVTTGILTIGDFRQKHIAAGGEGAPLAVYGDYLFFTSKQENRILLNMGGIANLTFLPCSADASAVFSSDIGPGNTIMDAYVQRHFSPLHYDKDSAMASQGKVHLGLLDSLLEHAFFALDFPKTTGPEVFNLDYLSVAQAHSATRQLAHEDVLATLNLFSARTIANAINDAAIELEEFNVYASGGGIHNPLLMEHILRLCPNVTAIQDTSKLGIDPDAKEAVLFAILANECLVGGQQPFGNLEQGIPNITMGKISFPD
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 43490 Sequence Length: 401 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q9I5Q5
MPRYLGLMSGTSLDGMDIVLIEQGDRTTLLASHYLPMPAGLREDILALCVPGPDEIARAAEVEQRWVALAAQGVRELLLQQQMSPDEVRAIGSHGQTIRHEPARHFTVQIGNPALLAELTGIDVVADFRRRDVAAGGQGAPLVPAFHQALFGDDDTSRAVLNIGGFSNVSLLSPGKPVRGFDCGPGNVLMDAWIHHQRGEHFDRDGAWAASGQVNHALLASLLADEFFAARGPKSTGRERFNLPWLQEHLARHPALPAADIQATLLELSARSISESLLDAQPDCEEVLVCGGGAFNTALMKRLAMLMPEARVASTDEYGIPPAWMEGMAFAWLAHRFLERLPGNCPDVTGALGPRTLGALYPA
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa . Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 39120 Sequence Length: 363 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q3K5W7
MALYIGVMSGTSLDGLDIALIEQSSAINLVATHYIPMPDTLRAELLGLCAGGPDEIARSAIAQQNWVKLAAQGIHTLLEQQQLKPEAIRAIGSHGQTIRHEPARGFTVQIGNPALLTELTGITVVSDFRSRDVAAGGQGAPLVPAFHEALFEERTGNRAVLNVGGFSNLSLIEPNKPVAGFDCGPGNVLMDAWIHQQRGENYDRNGQWAASGKVEPTLLKALLSDPFFVTQGPKSTGREVFNLPWLEQQLSCLPGFAAENVQATLLELTALTIVESLQSAQSNTEELLVCGGGAHNVTLMKRLADLLPNAKVASTATHGVDPDWVEAMAFAWLAHCCLEGIAANRPSVTGAKGLRVLGAIYPN
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 38607 Sequence Length: 363 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q88QQ4
MALYLGVMSGTSLDGLDIALVEQGEQLELLATHYLPMPPDLRQDLLALCSSGPDEIARAALAENRWASLAGEGIRQLLARQGLKPEAVRAIGSHGQTIRHEPARGFTVQIGNPALLAELTGISVVADFRRRDVAAGGQGAPLVPAFHETLFSQLGRRLAILNVGGFSNLSLIEQDKPVHGFDCGPGNVLLDAWIEREHGHPYDADGAWAASGVAQPGLLSALMADPFFAGSGPKSTGREVFNLPWLDRHLANLPAYRAQDVQATLLELTARSIIDSLGKAQQGTEALLVCGGGARNGALMARLGQLLPAARVASTGAYGVDPDWVEAMAFAWLAHCCLEGIAANRPSVTAAKGLRVLGAIYPA
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.putida . Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 38236 Sequence Length: 363 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q3ICY1
MHPHISKLYNSALKPSRLIIGLMSGTSLDGLDVALCKITAAGVHTQIEVLKFTTVDYSDDYKTKIKQVFAKRECNLEYLTLLHPWVGKFHGDMVNQCLNSWQVNPANIDVIASHGQTIYHCPKSQHQYNDFNNGTLQIGDSDQIAVTTGITTIGDFRQKHIAAGGEGAPLAVYGDYLFFSSSDENRILLNMGGIANLTFLPQNGDSNAVFSSDIGPCNTIMDAYVQRYFNNMHYDENAAIAKAGFINTALLTALCDNHFLTLKMPKTTGPEVFNLAYLEAAQQASNTQKLSHQDVMATLNRFTAEVIANALNTCVKMAPNSVVYASGGGIHNLLLMQHLVTLCPAIKGFKNTHALGVDPDAKEAVLFAILANECLAGEQLHLDNKAQGIAGVTMGKVSFAD
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 43557 Sequence Length: 401 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q4FQ90
MDDLNYATLTEALEQTVFENFDDGLYIGMMSGTSLDGMDAILCQFSNHTNSSNISNEDNTQQPMHLLATYSQDFPPRLREVLLALCQPNGINQLTPTAGEPDSELEWFGWASKAYAEFASDVVNTLLQQSNTDIESVLAIGCHGQTVRHRPQMGFSLQLVDANIIAERTGISVVSDFRRRDMAVGGQGAPLVPAFHQALFAVPDSTRILLNLGGIANIAVLPAISDDLSDFNEHSDNQPSDSVVGYDTGPANLLLDAWTALHTDKDYDAGGTWAQSGQVVEPLLNQLLEHPFFVKAYPKSTGREDFNLAWLQDELQKFDQAAADIRYSSADVQATLTELTAISASAQINIFINASSNNAVYVCGGGALNDYLMMRLQAHLPRCKVETTASLGLEPTWVEAVAFAWLARQTLMGETGNLPAVTGASKGVVLGQVCFA
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 47228 Sequence Length: 436 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q8Y241
MTTLASSISERYIGLMSGTSLDGVDGVLVDFSGPRPMLLTDAYVPFPPALRQAFFDLQSAGHNEIHREALAANALADLYAECVAQLLHESGCDPREVRAIGAHGQTIRHQPGEHDGIGYTRQTQHAAVLAERTGIDVIADFRSRDIAAGGQGAPLVPAVHRALFALPDAWRVVCNIGGIANLTVLPPQQSDARDRVLGFDCGPGNALLDYWVHAHRGEAYDRNGEWARSGWIDAALLETLRSEPFFARMPPKSTGRDLFNPTWLQQQAGDTLERIRPEDVQATLLALTADTIADAVRTHAPRTASLVVCGGGARNGALMQRLAAQLPGTLVAASDDFGVPAHQVEALAFAWLARQCVRREPGNVYHATGAAGPRVLGTIYPA
Function: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Catalytic Activity: 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate Sequence Mass (Da): 40965 Sequence Length: 382 Pathway: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. EC: 2.7.1.170
Q6P6B7
MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAMT
Function: Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. Sequence Mass (Da): 39284 Sequence Length: 361 Domain: Side chains of Lys-102, Lys-135 and Lys-165 capture Ser that is misactivated by AARS/AlaRS. Subcellular Location: Cytoplasm
A2AS55
MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAWKTESNIRRTPLHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDLTGTLAQQLTRSVDILQDFDHDVKS
Function: Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity . Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides . Sequence Mass (Da): 39776 Sequence Length: 361 Domain: Side chains of Lys-102, Lys-135 and Lys-165 capture Ser that is misactivated by AARS/AlaRS. Subcellular Location: Cytoplasm
Q499M5
MAPPGDPRRLCRLVQEGQLRALREELEVAGGCWDPEMFRGSQGPAGDTLLHFASRHGRQDILAYLVEAWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDVWKTESKIRRTPLHTAAMHGCFEAVQELLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLENHEACSSATDSLGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALLYAAKEGQTSTVQTLLSLGADINSTDERNRSALHLACAGQHAACARFLRQSGLKDSADLTGALAQQLTRGVAILQDFDPGVKS
Function: Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. Sequence Mass (Da): 40560 Sequence Length: 370 Domain: Side chains of Lys-111, Lys-144 and Lys-174 capture Ser that is misactivated by AARS/AlaRS. Subcellular Location: Cytoplasm
Q945B4
MGSCSPQLPLICLSDQTLKPGSSKWVKVRSDVRKALEDYGCFEAKIDQVSMELQGSVLKAMQELFALPTEAKQRNVCPKPFAGYFSHNGLSESFGIKDANILEKAHEFTQQLWPEGNKSIKMIQLYAEKLAELDMMVRRLILESYGIEYFIDEHLNSTYYRMRLMKYIARPDNDITAAVGANVDNGANDNADGDANVNDDGASIGVKVNVDVGDDVNDNDSVNIGVGVDINVETNVNGDLDAEANGDATAWVVGAVSGNASVGAKEANVDAELGLPSHTDKSLSGIIYQHQIDGLEVKTKEGKWIRVKPAPNTVIVIAGDALCALMNGRIPSPYHRVRVTERKKTRYAAALFSYPKEGYIIDSPKELVDEKHPRAFKPFDFVDLFNFYHTEAGRRAPSTLQAFCGVSAGK
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: 2-oxoglutarate-dependent dioxygenase involved in glucosinolates biosynthesis. Catalyzes the conversion of methylsulfinylalkyl glucosinolates to hydroxyalkyl glucosinolates. Sequence Mass (Da): 44943 Sequence Length: 410 EC: 1.14.11.-
Q8NK92
MRPLSHLSFFNGLLLGLSALSAATSVVHERREATSSNWVKRARVNPSDKHVVRIGLTQSSLEEAHDLLMDVSNPSSPNYARFYSADEVAAKFAPSTETVNEVQNWLTEKGINASRVAQTQNHGWLVFHATSKEIENLFDTTYYEYHNRKTGKKAIACEQYHVPASVQKHIDYVHPGVNLNPSSGKPSSIRRRAAASKKTKLPARGPRPIQQHDVKGLNVTNCDQLITPECIRALYKIPSARAAPHPNNSLGIFEEGDYYAQEDLDLFFKTFAKDIPQGTHPIPAFIDGAEAPVPVTKAGGESDLDFELAYPIVHPQSITLYQTDDANWASNTTGFLNTFLDALDGSYCTYCAYGECGNDPSLDPVYPDDAGYDGQLMCGVFKPTNVISVSYGEQENDLPANYQQRQCMEFLKLGLQGVSVLFASGDNGVAGPPGDGNSVNGCLNNGTVFSPAFPNSCPYITNVGATKVYPGYTVSQPESAVYDPDGLYSYASGGGFSNIYPIPDYQAEAVATYFKDHNPPYPYYEGAENLGKNGGLYNRLGRGYPDVAANGDNIAVFNGGEFGSSGGTSASTPIFASIINRIIDERLAVGKGPVGFINPVLYKNPSVLNDITNGTNPGCGTDGFSTAPGWDPATGLGTPNYPKMLKLWLDLP
Cofactor: Binds 1 Ca(2+) ion per subunit. Function: Serine endopeptidase which hydrolyzes a range of fluorogenic peptide substrates containing the basic residues arginine or lysine at the P1 position and prefers paired basic resides. Also hydrolyzes clupeine and salmine, activates plasminogen and converts trypsinogen to trypsin. PTM: N-glycosylated. Sequence Mass (Da): 70501 Sequence Length: 652 Subcellular Location: Secreted EC: 3.4.21.-
Q9ZUC1
MNAALATTTATTPVLRRETPLLHYCSLTTKSPVYQINRVRFGSCVQTVSKKFLKISASSQSASAAVNVTADASIPKEMKAWVYSDYGGVDVLKLESNIVVPEIKEDQVLIKVVAAALNPVDAKRRQGKFKATDSPLPTVPGYDVAGVVVKVGSAVKDLKEGDEVYANVSEKALEGPKQFGSLAEYTAVEEKLLALKPKNIDFAQAAGLPLAIETADEGLVRTEFSAGKSILVLNGAGGVGSLVIQLAKHVYGASKVAATASTEKLELVRSLGADLAIDYTKENIEDLPDKYDVVFDAIGMCDKAVKVIKEGGKVVALTGAVTPPGFRFVVTSNGDVLKKLNPYIESGKVKPVVDPKGPFPFSRVADAFSYLETNHATGKVVVYPIP
Function: Reduces the double bond in short-chain unsaturated carbonyls . Acts preferentially on alpha,beta-unsaturated ketones rather on alpha,beta-unsaturated aldehydes . Has no activity with (E)-2-hexenal and (E)-2-pentenal . Contributes to detoxify stromal reactive carbonyls produced under oxidative stress . Sequence Mass (Da): 40986 Sequence Length: 386 Subcellular Location: Plastid EC: 1.3.1.-
Q9V035
MFGYWGKILRVNLTDGTIKEETFNEEFAKKWLGTRGFGIYFLLKEMDPKVDPFSPENKLIFATGPLTGTSAPTGGRYMVITKSPLTGYIAMANSGGYFGAELKFAGWDAIIIEGKADHPVYLYIHDENVEIRDASKVWGKLVSETEKALKEEVGDKHVQIASIGPAGENKVRFAAVMNNGHRAAGRGGVGAVMGSKNLKAIVVRGHKRVEVADKGKFMEVIREKIEKLKKDPVAGGGLPKYGTAVLVNIINEHGLYPTRNFQTGVFEYAYEQSGEAMAAKYLIRNKPCFACPIGCGRVNYLPSIGETEGPEYESTWALGANLGINDLASIIEANHFADEYGMDTISLGGTLATAMELYERGLIKQEDIGGENEPPFRFGNTEVLHYWIHKIAKREGFGDILAEGGYRLAERFNGTEYFMGVKKQELPAYDPRGAEGHGLGYATNNRGGCHIKQYMISPEILGYPYKMDPHDISDEKVKMVILFQDLTALIDAAGLCLFTTFGLGADDYRDMLNAALGWDFSTEDYLKIGERIWNAERLFNLKAGLDPLKEDTLPKRLLEEPMPEGPNKGHVVRLKEMLPRYYKLRGWTEDGRIPEEKLKELGLEEFI
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Catalytic Activity: an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 67520 Sequence Length: 607 EC: 1.2.7.5
Q51739
MYGNWGRFIRVNLSTGDIKVEEYDEELAKKWLGSRGLAIYLLLKEMDPTVDPLSPENKLIIAAGPLTGTSAPTGGRYNVVTKSPLTGFITMANSGGYFGAELKFAGYDAIVVEGKAEKPVYIYIKDEHIEIRDASHIWGKKVSETEATIRKEVGSEKVKIASIGPAGENLVKFAAIMNDGHRAAGRGGVGAVMGSKNLKAIAVEGSKTVPIADKQKFMLVVREKVNKLRNDPVAGGGLPKYGTAVLVNIINENGLYPVKNFQTGVYPYAYEQSGEAMAAKYLVRNKPCYACPIGCGRVNRLPTVGETEGPEYESVWALGANLGINDLASIIEANHMCDELGLDTISTGGTLATAMELYEKGHIKDEELGDAPPFRWGNTEVLHYYIEKIAKREGFGDKLAEGSYRLAESYGHPELSMTVKKLELPAYDPRGAEGHGLGYATNNRGGCHIKNYMISPEILGYPYKMDPHDVSDDKIKMLILFQDLTALIDSAGLCLFTTFGLGADDYRDLLNAALGWDFTTEDYLKIGERIWNAERLFNLKAGLDPARDDTLPKRFLEEPMPEGPNKGHTVRLKEMLPRYYKLRGWTEDGKIPKEKLEELGIAEFY
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the oxidation of aldehydes to their corresponding carboxylic acids. May have a pyroglycolytic (saccharolytic) role. Catalytic Activity: an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 66631 Sequence Length: 605 EC: 1.2.7.5
Q8GZP5
MANTKDSYHIITMDTKESSIPSLPMKEIPGDYGVPFFGAIKDRYDFHYNQGADEFFRSRMKKYDSTVFRTNVPPGPFNARNSKVVVLVDAVSYPILFDNSQVDKENYFEGTFMSSPSFNGGYKVCGFLGTSDPKHTTLKGLFLSTLTRLHDKFIPIFTTSITSMFTSLEKELSEKGTSYFNPIGDNLSFEFLFRLFCEGKNPIDTSVGPNGPKIVDKWVFLQLAPLISLGLKFVPNFLEDLVLHTFPLPYILVKRDHQKLYNAFYNSMKDILDEAEKLGVKRDEACHNFVFLAGFNSYGGLKVFFPSLIKWIGTSGPSLHARLVKEIRTAVKEAGGVTLSAIDKMPLVKSVVYETLRMDPPVPFQTVKARKNIIITNHESSFLIKKDELIFGYQPLATKDSKVFKNAEEFNPDRFVGGGEKLLKYVYWSNGKEIDNPSVNDKQCPGKDLIVLMGRLLVVEFFMRYDTFEVEFGKLLLGSKVTFKSLTKATS
Function: Cytochrome P450 metabolizing both 13- and 9-hydroperoxides of linoleic and linolenic acids, but with a marked preference for 9-hydroperoxy fatty acids . Has no activity toward 13S-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) . Catalyzes not only the synthesis of allene oxide, but also its hydrolysis and cyclization . The first step is the synthesis of (12Z)-9,10-epoxyoctadeca-10,12-dienoic acid (9,10-EOD) and the final products are (9R)-alpha-ketol and the racemic cis-10-oxo-11-phytoenoic acid . The cyclase activity possesses regiospecificity and (9Z)-12,13-epoxyoctadeca-9,11-dienoic acid (12,13-EOD) is significantly less efficient as a substrate for cyclopentenone production than 9,10-EOD . Has no hydroperoxide lyase activity . May play a defensive role against soil-borne pests that affect roots or juvenile tissues as they emerge from the germinating seed . Catalytic Activity: (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O Sequence Mass (Da): 55514 Sequence Length: 491 EC: 4.2.1.92
Q3SYW1
MSASAVFILDVKGKPLISRNYKGDVAMSEIDHFMPLLMQREEEGALTPLLSHGRVHFLWIKYSNLYLVATTLKNANASLVYSFLYKIVEVFSEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTDSKILQEYITQQGNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGSIKLKVFLSGMPELRLGLNDRVLFELTGRSKNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPEKNTVIWSIKSFPGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDYQLRTS
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. PTM: Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals. Location Topology: Peripheral membrane protein Sequence Mass (Da): 48150 Sequence Length: 423 Subcellular Location: Cytoplasmic vesicle
P35602
MATSAMFILDLKGKTIISRNYRGDIDMTAIDKFIHLLMEKEEEGSAAPVLTYQDTNFVFIKHTNIYLVSACRSNVNVTMILSFLYKCVEVFSEYFKDVEEESVRDNFVVIYELLDEMMDFGFPQTTESRILQEYITQEGQKLISAPRPPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNMLASANGTVLQSEIVGSVKMRVYLTGMPELRLGLNDKVLFEGSGRGKSKSVELEDVKFHQCVRLSRFDTDRTISFIPPDGAFELMSYRLTTVVKPLIWIETSIERHSHSRVSFIIKAKSQFKRRSTANNVEIIIPVPSDADSPKFKTSIGSVKYTPEQSAFVWTIKNFPGGKEYLLTAHLSLPSVMSEESEGRPPIKVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGEYEMRMK
Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles (Probable). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (Probable). Required for many aspects of development and behavior, including negative regulation of vulval differentiation . Required for the dendritic localization of potassium channel kvs-4 in the cholinergic motor neuron DA9 . Location Topology: Peripheral membrane protein Sequence Mass (Da): 48229 Sequence Length: 422 Subcellular Location: Golgi apparatus
P47795
MIHSLFLMNGGGAVFLEKHWRSVVSRSVCAYLLEAQLKAGQPENVAPVLATPHHYLVSTHRHGISFVAVIQAEVPPLFVIEFLHRVAETLQDYFGECSEASIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDQLPTGQLSNIPWRRVGVKYTNNEAYFDVTEEIDAIIDKSGSTVFAEIQGVIDACIKLTGMPDLTLSFLNPRLLDDVSFHPCVRFKRWESERVLSFIPPVGNFRLMSYHVNSQNLVAIPVYVKHNINFRDDGSTGWFDITIGPKQTMGKVVENILVIIHMPKVVLNMTLTAAQGNFTFDPVTKVLIWDIGKIILPKLPTLKGLINLQSGEAKPEENPTLNIQFRIQQLAVSGLKVNRLDMYGERYKPFKGVKYVTKAGKFQVRT
Function: Component of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP47 is a subunit of the plasma membrane adapter. PTM: Regulated by phosphorylation. Location Topology: Peripheral membrane protein Sequence Mass (Da): 46772 Sequence Length: 418 Subcellular Location: Golgi apparatus
Q8LEZ8
MIHFVLLVSRQGKVRLTKWYSPYTQKERSKVIRELSGVILNRGPKLCNFIEWRGYKVVYKRYASLYFCMCIDEADNELEVLEIIHHYVEILDRYFGSVCELDLIFNFHKAYYILDELLIAGELQESSKKTVARIISAQDQLVEVAKEEASSISNIIAQATK
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 18759 Sequence Length: 161 Subcellular Location: Golgi apparatus
P61966
MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEWRDLKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMGGDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Location Topology: Peripheral membrane protein Sequence Mass (Da): 18733 Sequence Length: 158 Subcellular Location: Golgi apparatus
P56377
MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEEAETPRSVLEEIGLT
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Location Topology: Peripheral membrane protein Sequence Mass (Da): 18615 Sequence Length: 157 Subcellular Location: Golgi apparatus
Q96PC3
MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQEVSTVSQTMGER
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking . Location Topology: Peripheral membrane protein Sequence Mass (Da): 18280 Sequence Length: 154 Subcellular Location: Golgi apparatus
O94669
MSTIEAIYLVDTNGALLLQLESRGRTSPITLEHIKNELFRYKLRNEEPPFILHNKNFLIFQELEEDVRLCIPTTCDTEPLYIHDIMRRIVDVVKTFFGGFNASKVEKNVCVIVQLLAEMIDYGYATCMEPNALQDIVPLPSFMNKFMAVTGLQTNTPTLARDTVPWRTAKAKYATNEFFIHVLERVSAVYQPNGKLAFGTVKSDMECKCQISGMPLLLLSLRPGTKLGNVRFHQSVNLKRWKQHPDQIEFIPPDGKFTLASFQTDFATQKSLPVVVEAKNKLDGRFEVRIRNTGKKSVENLKILITIPQALKSVTVTEGNYIFRASKYTHMEEGILEWSVKKLAWTSPALVLTGFLAPLKKDANSTEESSSYSKLEHLDLQYKLQGSTLHNFKVESLKMLNHPDKKSYKGVKHTIIAQNVSFRFR
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 48422 Sequence Length: 425 Subcellular Location: Cytoplasm
P38153
MYLSFYITDTKNKLIFQYLLGATAPSFKHLWTRVQSTCPQLLEDSSSDDYLDHSMVGRDLEVYKYFSVINKLNYWCLASTSKSKGPLDCFTFLETIDRILLEYFDKDKLSIKKIVNNYDRISLIFNCCVEAGEPNVSDMLYVNKIKEAVPERSDLSKFISSTAHNLQQAVQLPQQRQQQLQQNQISRGSNSLIENEEIVPWRTSRASKHENNELYVDLLETFHVVFEKKKSHLRLLTGSIHGIVDVRSYLNDNPLVAVKLNTMGNDIGIPSLHDCVEINDGVFSPSNITFIPPDGKFRLLEYSVDLSSQVKQSGVRMNSIGLMSLHFQNGLGKDSDEFELSLNIENFKKVSQVDDLKIDLQFNVENADPNEIAYKIKILRNTHGRFENSIIMGQGQWIFDKSTATGTVPVLRGCIEYENTGPNFTKKVDLQTVSLEYSYIGQSASGIYVEAIDIVSGLTIGKNTKLYKGAKYKTQTGNFQVRL
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole. Location Topology: Peripheral membrane protein Sequence Mass (Da): 54837 Sequence Length: 483 Subcellular Location: Golgi apparatus
Q92572
MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Location Topology: Peripheral membrane protein Sequence Mass (Da): 21732 Sequence Length: 193 Subcellular Location: Golgi apparatus
Q1JQA3
MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEMPRNINIGDLNIKVPNLSQFV
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 22035 Sequence Length: 193 Subcellular Location: Golgi apparatus
P59780
MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Location Topology: Peripheral membrane protein Sequence Mass (Da): 22017 Sequence Length: 193 Subcellular Location: Golgi apparatus
Q8VZ37
MIKAVMMMNTQGKPRLAKFYDYLPVEKQQELIRGVFSVLCSRPENVSNFLEIESLFGPDSRLVYKHYATLYFVLVFDGSENELAMLDLIQVLVETLDKCFSNVCELDIVFNYSKMHAVLDEIVFGGQVLETSSAEVMKAVEEISKLEAASNSISLVPKSVSGWRGR
Function: Part of the AP-3 complex, an adaptor-related complex which seems to be clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. It also function in maintaining the identity of lytic vacuoles and in regulating the transition between storage and lytic vacuoles (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 18729 Sequence Length: 166 Subcellular Location: Cytoplasm