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11.1k
Q54RB9
MFANRVRQAQKLYQKRFFSLGNNSTISKQQFKNSSNNNNNKNGGNKNGFYQKAFIATTVALTTTLLTATTLLDDNTNSEKEILKSQRQTFEKYASTTLEGERQMTAEDFLSALTTLESDKQSGEHEILKASLDADKFKVLFQMADVDHTGYISFDEYVMFDELMAKPEAEYFLAFKLFDRDGNGYISKNDFKHVITASLDPSIPFNFDCELVNLYFGDGRTELNYSQFTQLLKDLQQERIKQEFKFHDKYNSGYIPRDKFAKVLGSVKLRKIPDHVRDKLESISELNLLSGHPNEVSYSQFVAANDMLLHIPSYGRVLKAAILKNKKDNINKEEFLTEARSSTSIEITPLEIDLIFHLFDLNKDGKLSISDFEKSTGLNINKIGGGTNYSDSYPSDSHVTIQNSSTTPSPSTPITNTAAAIALNKKHGKTFAQQVLESIENFALGSIAGGIGAAAVYPIDLVKTRMQNQRAVDPAKRLYVNSWDCFKKVVKFEGVRGLYKGILPQMVGVAPEKAIKLTVNDLLRDLFGDKSKGEIYFPLEVLAGGFAGMSQVCVTNPLEIVKIRLQVQSTGPKVSAITIIKELGLAGLYKGAGACLLRDIPFSAIYFPTYAKMKTILANEDGKLGPMDLLLAGAVAGIPAASLVTPADVIKTRLQVKANAGEQTYTGIRDCFQKILKEEGPRALFKGALARVFRSSPQFGVTLVSYELLQKALLPDAEYKPPTNAPITQKDFDVIRGNTNTVQRVIDMESKFGTLHQTRDNNKSSNGGENKN
Function: Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 85648 Sequence Length: 772 Domain: Upon calcium binding, the EF-hand-containing regulatory N-terminal domain binds to the C-terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain. In the absence of calcium, the linker loop domain may close the vestibule, which may prevent substrates from entering the carrier domain. Subcellular Location: Mitochondrion inner membrane
A0A2K3D5Z7
MSVALASEYQLVQNAQLPQRWSQSARKSLAILEATARKEATAQMEAAGGSFCGQFPVDPAFKVLSLEYSAPNPDIARAIRRVDSVPNPPLPSHVVAIQSTAVDADLSLAMGVSLTPGRHTSYLVDARALQQSNSAAVAARKADGDKWGPACDEMFRGCRCVTGQEVVFYTAVKEPAGEVEGGEGSLFKPSFDGPAFRPSWGELSGKATGVVACVLQVPIGKETDIICAEYDNLVSKGQFATVDRFGGDHTVNMTGNALIQNDGKAISKGYAVAHRARVTSNVYGKANDVSLQRLAETVWSVVEKRLSFMPAYRDLVITEQGKPFMLGATATNIISLTENQGVMLHLDTDDGVWTIILWFHRHSGIIAGGEFVLPSLGISFQPLDFTIVVFAANTIVHGTRPLQTTGKIIRWGSSHFLRFKDVNALAQLGAAYGVDELDAKQRDQLEEVDAANSKDGVGAARRVASCMAAERKAAIEAQKAACVRGVVMNPCTGRMPSLLFWQVWRKPPALAVRANAVAGKKRAAADVDFCGA
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that catalyzes DNA modification by mediating the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-glyceryl-methylcytosine (5gmC) . Catalyzes the conjugation of a glyceryl moiety from L-ascorbate (vitamin C) to the methyl group of 5mC through a carbon-carbon bond . 5gmC DNA modification may be required during photosynthesis as an epigenetic mark that couteracts DNA methylation . Catalytic Activity: a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate Sequence Mass (Da): 56994 Sequence Length: 532 Subcellular Location: Nucleus EC: 1.14.99.-
Q9U641
MDSKYIQKTLSAITEQITKNAAVQKVLDNKFVKEHKYAAAAATVGLGVVAATTIVKAVNCEGKRYNYDAIPNLSFDDESIYDVATIGAGPSGSVLGYYLAREGRKVALLEKKVFPRDKYCGDAVATMAQDILREMGVMKELVDEDLGHFAQNGGFVSPNGNSFIGNSAKELKRDAKYNRGAVIAVKRIVLDEKVAKAAKRMGADLKENTTVENATFDRSTGVWTINCVDSEDNTKKIVYRARVLVCADGSPSNAARQLGYVHTEPNGICSRAYVKNNTTFRYDGVVFYPPSLLPGYCAIIREARDELNYLAYIIPGGKVTNDDLSKYHHQYMTEDPFISAALGPNPDIERMKAAPLRLGGIKKSYDDHLLIVGDAAGFIDPLTGEGIQYAMEGSRLASLALIQAFNERDLSHQSLKRYQDFWMAKFGHEFSMSMTMSLFLYRFPIVLDAAASLIEKRGSRFLAEWAAVMTGVKPKTWFLRPDVGPLIVLEIFGECFRRVFQGKKQIKKLD
Function: Receptor for cmfA, that appears to mediate the G-independent cmfA signal transduction. Location Topology: Single-pass membrane protein Sequence Mass (Da): 56497 Sequence Length: 510 Subcellular Location: Membrane
Q2I2P8
MPKLGVSLFIFLVLFPLATLQLDGDQSAGRHAQERGEDLFKMYQYLRRALERRRTGEDFLEECMGGCAFDFCCKRSLRDTTSD
Function: This toxin inhibits both the TTX-sensitive and TTX-resistant sodium currents in adult rat dorsal root ganglion neurons. The inhibition on TTX-resistant sodium currents is stronger than on TTX-sensitive sodium currents . When intracranially injected into mice, the toxin induces tremors (50 nM), spasms (100 nM), and death (200 nM) . PTM: Authors of PubMed:25600641 studied the activity of this peptide with the C-terminal Arg residue, which is probably cleaved in the native peptide. Sequence Mass (Da): 9572 Sequence Length: 83 Domain: The cysteine framework is XVI (C-C-CC). Subcellular Location: Secreted
P05059
MRSAAVLALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQKKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEKRDDFKEVEKSDEDSDGDRPQASPGLGPGPKVEEDNQAPGEEEEAPSNAHPLASLPSPKYPGPQAKEDSEGPSQGPASREKGLSAEQGRQTEREEEEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQRAAPGWPEDGAGKMGAEEAKPPEGKGEWAHSRQEEEEMARAPQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMDQLAKELTAEKRLEGEEEEEEDPDRSMRLSFRARGYGFRGPGLQLRRGWRPNSREDSVEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLEELRRG
Function: Strongly inhibits glucose induced insulin release from the pancreas. PTM: In secretory granules, is attacked at both N- and C-terminal sides by proteolytic enzymes generating numerous peptides of various activities. Proteolytic processing can give rise to additional longer forms of catestatin peptides which display a less potent catecholamine release-inhibitory activity . Sequence Mass (Da): 50015 Sequence Length: 449 Subcellular Location: Secreted
P10645
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
Function: Strongly inhibits glucose induced insulin release from the pancreas. PTM: Sulfated on tyrosine residues and/or contains sulfated glycans. Sequence Mass (Da): 50688 Sequence Length: 457 Subcellular Location: Secreted
P04404
SAAALALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERSHQQKKQSSYEDELSEVLEKQNDQAELKEGTEEASSKEAAEKRGDSKEVEKNDEDADGAKPQASLEPPXXXEAEDQTPGEEEAASTHPLASLPSKKRPGAQAEEDHEGPSQGPVDREKGPSAEQGPQAEREEEEEAEAGEKAVPEEEGPRSEAFDSHPSLGYKEMQRGWPQAPAMDGAGKTGAEEAQPPEGKGAREHSRQEEEEETAGAPQGLFRGGKRGEPAQEEEERLSEEWENAKRWSKMDRLAKELTAEKRLQGEEEEEEEEEDPDRSMKLSFRAPAYGFRGPGLQLRRGWRPSSREDSVEAGLPLQVRXYLEEKKEEEGSANRRPEDQELESLSAIEAELEKVAPQLQSLRRG
Function: Strongly inhibits glucose induced insulin release from the pancreas. PTM: O-glycosylated; contains chondroitin sulfate (CS). CS attachment is pH-dependent, being observed at mildly acidic conditions of pH 5 but not at neutral pH, and promotes self-assembly in vitro. Sequence Mass (Da): 49328 Sequence Length: 446 Subcellular Location: Secreted
Q12N04
MNSKQDRIYAKPAQTISDFQFDSRVAGVFNDMIRRSVPGYNQIIATLGDFARRYVTPNSKVFDLGSSLGSATLSIRRQIEGRQCQIIAIDNSQSMIERCEENLAAYVSDTQVTLVCDDIRNVDINNASMVVLNFTLQFLPPEDRDTLIKRIYDGMLPGGILVLSEKVKFDDACIQTLLDEQHLDFKRANGYSELEISQKRSALENVMRTDTLVQHQQRITDSGFSHFSVWFQCFNFASMVAIK
Function: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). Catalytic Activity: prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O Sequence Mass (Da): 27569 Sequence Length: 243 EC: 2.1.3.-
O34639
MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLRDILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR
Function: Involved in a cysteine salvage pathway from S-alkylcysteine. Catalyzes the reduction of N-acetyl-S-hydroxy-L-cysteine (N-acetyl-L-cysteine sulfenic acid) to N-acetyl-L-cysteine. This pathway is likely important in the catabolism of alkylated cysteine generated by proteolysis of alkylated glutathione formed in the detoxification of a wide range of electrophiles. Catalytic Activity: AH2 + N-acetyl-S-hydroxy-L-cysteine = A + H2O + N-acetyl-L-cysteine Sequence Mass (Da): 10628 Sequence Length: 93 Pathway: Amino-acid metabolism. EC: 1.8.4.-
O34974
MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQTAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTEPFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVRGLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAGSSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVADTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQSTTDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDIPGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH
Function: Involved in a cysteine salvage pathway from S-alkylcysteine. Catalyzes the C-S bond cleavage in N-acetyl-S-benzyl-L-cysteine sulfoxide leading to N-acetyl-S-hydroxy-L-cysteine and benzaldehyde. This pathway is likely important in the catabolism of alkylated cysteine generated by proteolysis of alkylated glutathione formed in the detoxification of a wide range of electrophiles. Has much less efficient activity with N-acetyl-S-methyl-L-cysteine sulfoxide as substrate. Cannot use S-alkylated L-cysteine sulfones and ketone analogs as substrates, demonstrating that the sulfoxide is required for activity. Catalytic Activity: (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 = benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine Sequence Mass (Da): 49411 Sequence Length: 442 Pathway: Amino-acid metabolism. EC: 1.14.14.-
P36566
MQDRNFDDIAEKFSRNIYGTTKGQLRQAILWQDLDRVLAEMGPQKLRVLDAGGGEGQTAIKMAERGHQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVASHLETPVDLILFHAVLEWVADPRSVLQTLWSVLRPGGVLSLMFYNAHGLLMHNMVAGNFDYVQAGMPKKKKRTLSPDYPRDPAQVYLWLEEAGWQIMGKTGVRVFHDYLREKHQQRDCYEALLELETRYCRQEPYITLGRYIHVTARKPQSKDKV
Function: Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs. Four tRNAs (tRNA(Ala1), tRNA(Ser1), tRNA(Pro3) and tRNA(Thr4)) are fully modified with mcmo5U in stationary-phase E.coli. Also present at low frequency in tRNA(Leu3) and tRNA(Val1). Catalytic Activity: 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine Sequence Mass (Da): 29814 Sequence Length: 261 EC: 2.1.1.-
O34846
MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAEHHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRIDLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQVDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAEFHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDIIVQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR
Function: Involved in a cysteine salvage pathway from S-alkylcysteine. Catalyzes the oxidation of N-acetyl-S-benzyl-L-cysteine and N-acetyl-S-methyl-L-cysteine to (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide and (R)-N-acetyl-S-methyl-L-cysteine sulfoxide, respectively. This pathway is likely important in the catabolism of alkylated cysteine generated by proteolysis of alkylated glutathione formed in the detoxification of a wide range of electrophiles. Catalytic Activity: FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 = (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O Sequence Mass (Da): 36944 Sequence Length: 334 Pathway: Amino-acid metabolism. EC: 1.14.14.-
P14204
MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQHDFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHGAISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECLILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL
Function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes. PTM: Phosphorylated by ComP. Sequence Mass (Da): 24129 Sequence Length: 214 Subcellular Location: Cytoplasm
O13067
MSTSTPQSGGRRKPETPDSAFLSPATRPQPISAAATPTLLNFTSNDDERERKLRRMSRVIDLQLSNANSPATAISPAQSRGADTPTSLLPKLNNTQISDHYSTCIKLSQENKITTKNAFGLHLIDYMGDILKHKDSELTNFKVAAGTLDASAKIYAVRVDAVHADVYKVLGGLGKESQATEDTENQETDTGPQDGRKNPKRRKCSYKTIERNLNSINRSETERKSEIDPLFQKAAASFDEFSTAGVFLSTLKCHSYHSELHFDADVKPLSTAEETEPPSPGSMDSTELKSLFLQCVEKRPLCPSLSGFRFMQWNSDAQNENLSLLMDKFKKSDHVFDINAEVEDDFVESEAPVADEFDADVCEGMDAGDIGEFAEHREACRLERKGAQLTQIGNGDIGTMCLQLSSCPGEYSYFSPRTMSMWAGPEHWRFRPRQKASTDSDQQRVKKAKKVFELNFEDDIDFEVHFRKTRAATTLTKSTLESQNKKSTTLPADFHYDPDNIARMSLRPKDRIRKTTVQESVSEPEDDIGDYDYNNPNDTSNFCPALQAADSDDDDGAFLGPESNSAGFSAENQMNITSYGESNLVAGQKVNKIEIQYAKTAKKMDMKRLKSSMWSLLANCPESQEEMPSSKEEIDAALITDEQVFSSVTHGLQKRLPPVMAQNLSVPLAFACLLHLANEKNLKLQGMDDLSDVMIMQDD
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerase. PTM: Phosphorylated by CDK1. Its phosphorylation, as well as that of XCAP-D2 and XCAP-G subunits, activates the condensin complex and is required for chromosome condensation. Sequence Mass (Da): 77778 Sequence Length: 699 Subcellular Location: Nucleus
Q9BPX3
MGAERRLLSIKEAFRLAQQPHQNQAKLVVALSRTYRTMDDKTVFHEEFIHYLKYVMVVYKREPAVERVIEFAAKFVTSFHQSDMEDDEEEEDGGLLNYLFTFLLKSHEANSNAVRFRVCLLINKLLGSMPENAQIDDDVFDKINKAMLIRLKDKIPNVRIQAVLALSRLQDPKDDECPVVNAYATLIENDSNPEVRRAVLSCIAPSAKTLPKIVGRTKDVKEAVRKLAYQVLAEKVHMRAMSIAQRVMLLQQGLNDRSDAVKQAMQKHLLQGWLRFSEGNILELLHRLDVENSSEVAVSVLNALFSITPLSELVGLCKNNDGRKLIPVETLTPEIALYWCALCEYLKSKGDEGEEFLEQILPEPVVYADYLLSYIQSIPVVNEEHRGDFSYIGNLMTKEFIGQQLILIIKSLDTSEEGGRKKLLAVLQEILILPTIPISLVSFLVERLLHIIIDDNKRTQIVTEIISEIRAPIVTVGVNNDPADVRKKELKMAEIKVKLIEAKEALENCITLQDFNRASELKEEIKALEDARINLLKETEQLEIKEVHIEKNDAETLQKCLILCYELLKQMSISTGLSATMNGIIESLILPGIISIHPVVRNLAVLCLGCCGLQNQDFARKHFVLLLQVLQIDDVTIKISALKAIFDQLMTFGIEPFKTKKIKTLHCEGTEINSDDEQESKEVEETATAKNVLKLLSDFLDSEVSELRTGAAEGLAKLMFSGLLVSSRILSRLILLWYNPVTEEDVQLRHCLGVFFPVFAYASRTNQECFEEAFLPTLQTLANAPASSPLAEIDITNVAELLVDLTRPSGLNPQAKTSQDYQALTVHDNLAMKICNEILTSPCSPEIRVYTKALSSLELSSHLAKDLLVLLNEILEQVKDRTCLRALEKIKIQLEKGNKEFGDQAEAAQDATLTTTTFQNEDEKNKEVYMTPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVPEPESEMKMRLPRRAKTAALEKSKLNLAQFLNEDLS
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. PTM: Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity). Sequence Mass (Da): 114334 Sequence Length: 1015 Subcellular Location: Nucleus
A0A059WLZ7
MFLQNAWYAVAWCDEVTDGIVTRKVLGRELALFRDGEGQPRAILNRCPHRFAPLSLGKRIGDAIQCPYHGLHFGPDGRCVHNPHGDGVVPDVATPTFPARERHKLIWAWMGDPALATDDIAGGEYGYLDDVELDLLPRGHLHLDCDYRLVIDNLMDPAHVAVLHDSALASEALIRAVPRVWREEDVIRVESWAPDSKPSFLFGAWLGNHDDPVDHWVASRWQAAGLLSVEGGVVAVGGDREDGLRVRGAHMITPETETSAHYFWAVVRNFREDDAEQSEQIRATTAAIFTGEDKWMLEAIERSMDGEEFWSLRPAILGTDRAAVMVRRALESEIKAEGRPKVVAVSAG
Cofactor: Binds 1 [2Fe-2S] cluster per subunit. Function: Component of the chloroacetanilide N-alkylformylase multicomponent enzyme system involved in the degradation of chloroacetanilide herbicides (N-alkoxyalkyl-N-chloroacetyl-substituted aniline derivatives). In vitro, catalyzes the N-dealkylation of butachlor, alachlor and acetochlor to yield 2-chloro-N-(2,6-diethylphenyl)acetamide (CDEPA) (for alachlor and butachlor) and 2-chloro-N-(2-methyl-6-ethylphenyl)acetamide (CMEPA) (for acetochlor). Catalytic Activity: butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 38664 Sequence Length: 348 EC: 1.14.15.23
P9WP64
MHRLRAAEHPRPDYVLLHISDTHLIGGDRRLYGAVDADDRLGELLEQLNQSGLRPDAIVFTGDLADKGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCYTQDLTVAAGGTRGRDGAQGCNLVHVYPDTVVHSVIPLGGGETVGTFVSPGQARRKIAESGIFIEPSRRDSLFKHPPMVLTSSAPRSPVD
Cofactor: Binds 1 Fe(3+) ion per subunit. Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP. Catalytic Activity: a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+) Sequence Mass (Da): 34233 Sequence Length: 318 Domain: The C-terminal extension (CTE) is used to better adjust the substrates into the active sites and mediates in vivo subcellular localization of the protein. Subcellular Location: Cytoplasm EC: 3.1.4.16
Q2FVF0
MTLLTVKHLTITDTWTDQPLVSDVNFTLTKGETLGVIGESGSGKSITCKSIIGLNPERLGVTGEIIFDGTSMLSLSESQLKKYRGKDIAMVMQQGSRAFDPSTTVGKQMFETMKVHTSMSTQEIEKTLIEYMDYLSLKDPKRILKSYPYMLSGGMLQRLMIALALALKPKLIIADEPTTALDTITQYDVLEAFIDIKKHFDCAMIFISHDLTVINKIADRVVVMKNGQLIEQGTRESVLHHPEHVYTKYLLSTKKKINDHFKHVMRGDVHD
Function: Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for energy coupling to the transport system . Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro . Location Topology: Peripheral membrane protein Sequence Mass (Da): 30469 Sequence Length: 271 Subcellular Location: Cell membrane EC: 7.2.2.-
A0A0H3JTK0
MKGAMAWPFLRLYILTLMFFSANAILNVFIPLRGHDLGATNTVIGIVMGAYMLTAMVFRPWAGQIIARVGPIKVLRIILIINAIALIIYGFTGLEGYFVARVMQGVCTAFFSMSLQLGIIDALPEEHRSEGVSLYSLFSTIPNLIGPLVAVGIWNANNISLFAIVIIFIALTTTFFGYRVTFAEQEPDTSDKIEKMPFNAVTVFAQFFKNKELLNSGIIMIVASIVFGAVSTFVPLYTVSLGFANAGIFLTIQAIAVVAARFYLRKYIPSDGMWHPKYMVSVLSLLVIASFVVAFGPQVGAIIFYGSAILIGMTQAMVYPTLTSYLSFVLPKVGRNMLLGLFIACADLGISLGGALMGPISDLVGFKWMYLICGMLVIVIMIMSFLKKPTPRPASSL
Function: Involved in the export of the metallophore staphylopine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43295 Sequence Length: 397 Subcellular Location: Cell membrane
Q71DR4
MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLALDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTTHTITDAYAGKEYIIQVAAKDYEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLIHVPVTLALAAAAATANSLLI
Function: Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 40831 Sequence Length: 372 Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Subcellular Location: Cell membrane
P51641
MANPVPSACCVVLAAVVVVYAQRHSQQDSHIQYERVGADVTMKCGSMDWDAAVTWTANGTDIDDSHLNGSYLILKNVDLTQSGQYSCYEGSSWHLKYQTYLRVGVPPKEPVLMCRSNNYPKGFYCSWHLPSPTYIPNSFNISVIHGTREMVCEKDIFPKNRCHIRYLQLFSTVKYKVTLTVTNALGKNSTTLTFDEFAIVKPDPPESVVAKPVPNNPRRLEVSWQNPSSWPDPESFPLKFFLRYRPLILDQWQHVELSDGTSHTITDAYAGKEYIIQVAAKDNDIGTWSDWSVAVHATPWTEEPKHLTTEVQITETTSTSTSSFMPPPTTKICDKGAGVGSGAVAVCWTAGLVLAAYGVLFI
Function: Binds to CNTF (GPA). The alpha subunit provides the receptor specificity. Location Topology: Lipid-anchor Sequence Mass (Da): 40308 Sequence Length: 362 Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Subcellular Location: Cell membrane
P26992
MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
Function: Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 . Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1 . Location Topology: Lipid-anchor Sequence Mass (Da): 40633 Sequence Length: 372 Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Subcellular Location: Cell membrane
O88507
MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGADVTLPCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELGSGGGPSILFLTSVPVTLVLAAAAATANNLLI
Function: Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 40801 Sequence Length: 372 Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Subcellular Location: Cell membrane
Q08406
MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGTDVTLPCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLSAPTYIPNTFNVTVLHGSKMMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSNGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELSSGGGPSIPFLTSVPVTLVLAAAAATANNLLI
Function: Binds to CNTF. The alpha subunit provides the receptor specificity. Location Topology: Lipid-anchor Sequence Mass (Da): 40822 Sequence Length: 372 Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Subcellular Location: Cell membrane
Q2FVF1
MIKIKDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDQPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKEVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF
Function: Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for energy coupling to the transport system . Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro . Location Topology: Peripheral membrane protein Sequence Mass (Da): 28180 Sequence Length: 249 Subcellular Location: Cell membrane EC: 7.2.2.-
Q9HUX6
MVLDLLKSGVLLAVLASFTFSVMNALVKEASATLPAAEIVFFRSAIGTLLIYLLMRQAGVALSRQGVPMLLVRGVMGALYLVCYFYAIAHIPLADASILAHMSPFFVILFSALFLGERIPRAVYWLLLVVVLGALMIVKPFSYSSYSVYAVVGLLSAVFAAGASVAIRQLSARHHTYEIVFYFLAVATLVAIPLMWNDFVVPATLREWGLLLAIGVVSLLGQVFLTRAFSHESATIVAVTRYIGIVFNAGWGWLFWSEVPDALTIAGGVLIVVACIALSRTKKG
Function: Transports the metallophore pseudopaline, which is involved in the acquisition of nickel and zinc, and thus enables bacterial growth inside the host, where metal access is limited. Is probably involved in the export of pseudopaline (By similarity). Essential for iron acquisition during the interaction with airway mucus secretions (AMS) . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 30723 Sequence Length: 284 Subcellular Location: Cell inner membrane
A0A0H3JU78
MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGNDFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMPQAHRVVPTTINMGNHSWKALEIIYETYVHYVIPVKQVTTEIQHLVEAFVREQQWSHKYKTVGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGGSILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
Function: Catalyzes the reversible interconversion of the L- and D-stereoisomers of histidine. Functions in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, cobalt, zinc, copper, and iron, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to staphylococcal virulence. Appears to be specific for histidine, as it cannot use L-alanine and L-methionine as substrate. Catalytic Activity: L-histidine = D-histidine Sequence Mass (Da): 31004 Sequence Length: 273 EC: 5.1.1.24
C8CK74
MEKLTVLILVATVLLTIQVLGQSDRDKHLKRRPKQYATKRLSARMRGHRQCTGAGYECEETPECCPNLTCKCSGSPLCTRYSCQA
PTM: Contains 4 disulfide bonds. Sequence Mass (Da): 9546 Sequence Length: 85 Domain: The cysteine framework is XV (C-C-CC-C-C-C-C). Subcellular Location: Secreted
Q3SYW2
MDPLMAVLCLLPLYPGLATAALSCPKNVNISGGSFTLSNGWNPGSILTYSCPLGHYPYPVVTRLCKSNGQWQIPRSTRSTKAICKPVRCPAPVSFENGVYIPRLGSHPVGGNLSFECEDGFTLRGSAVRQCRPNGMWDGETAVCDNGASHCPNPGISVGAVRTGSRFGLGDKVRYRCSSNLVLTGSAERECQDDGVWSGTEAICRQPYSYDFPEDVAPALGTSFSHLLATTNPIQQKKKQNLGRKIQIQRSGHLNLYLLLDASQSVSKDDFEIFKDSASRMVDRIFSFEIKVSVAIITFASKPKIIMSVLEDRSRDVTEVENSLRNINYKDHENGTGTNIYEALHAVYIMMNNQMNRPHMNPGAWQEIRHAIILLTDGKSNMGGSPKVAVDNIKEVLNINQKRKDYLDIYAIGVGSLHVDWKELNNLGSKKDGERHAFILKDVQALSQVFEHMLDVSQLTDPICGVGNMSANASAQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRNAEDRTLWRVSVGDPNFQGSKEFQIEEAVISPGFNVFSKKSQGIPEFYGDDIALLKLTQKVKMSTHARPICLPCTVGANLALRKLPGSTCRDHEKELLNQVSIPAHFVALNGDKLNINLKTGSEWTNCVKVVLKDKTTFPNLTDVREVVTDQFLCSGTQGDDSPCKGESGGAVFLERRLRFFQVGLVSWGLYNPCGGSSKNSRKPAPHGKVPRDFHINLFRLQPWLRQHLEGILNFVPL
Function: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Catalytic Activity: Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b. Sequence Mass (Da): 82906 Sequence Length: 750 Domain: The MIDAS-like motif in the VWFA domain binds divalent metal cations. Subcellular Location: Secreted EC: 3.4.21.43
P06681
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
Function: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. Catalytic Activity: Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b. Sequence Mass (Da): 83268 Sequence Length: 752 Domain: The MIDAS-like motif in the VWFA domain binds divalent metal cations. Subcellular Location: Secreted EC: 3.4.21.43
Q03692
MLPQIPFLLLVSLNLVHGVFYAERYQMPTGIKGPLPNTKTQFFIPYTIKSKGIAVRGEQGTPGPPGPAGPRGHPGPSGPPGKPGYGSPGLQGEPGLPGPPGPSAVGKPGVPGLPGKPGERGPYGPKGDVGPAGLPGPRGPPGPPGIPGPAGISVPGKPGQQGPTGAPGPRGFPGEKGAPGVPGMNGQKGEMGYGAPGRPGERGLPGPQGPTGPSGPPGVGKRGENGVPGQPGIKGDRGFPGEMGPIGPPGPQGPPGERGPEGIGKPGAAGAPGQPGIPGTKGLPGAPGIAGPPGPPGFGKPGLPGLKGERGPAGLPGGPGAKGEQGPAGLPGKPGLTGPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGYPGAKGERGSPGSDGKPGYPGKPGLDGPKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHNGEAGPRGAPGIPGTRGPIGPPGIPGFPGSKGDPGSPGPPGPAGIATKGLNGPTGPPGPPGPRGHSGEPGLPGPPGPPGPPGQAVMPEGFIKAGQRPSLSGTPLVSANQGVTGMPVSAFTVILSKAYPAIGTPIPFDKILYNRQQHYDPRTGIFTCQIPGIYYFSYHVHVKGTHVWVGLYKNGTPVMYTYDEYTKGYLDQASGSAIIDLTENDQVWLQLPNAESNGLYSSEYVHSSFSGFLVAPM
Function: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Sequence Mass (Da): 66158 Sequence Length: 680 Subcellular Location: Secreted
A8HYS9
MDQRLDPGLSPYRTFTRAEWAQLREDTPMTLGAEEILRLQGLNDRLSIREVEEIYLPLSRLLSMYVGATQKLFRAMSQFLDHRNNAEGKMPYIIGVAGSVAVGKSTTARVLQALLARWPHTPKVDLVTTDGFLLPNAVLQREGLMEKKGFPESYDLSLLLRFLTDIKAGRRPVKAPLYSHFFYDVLPDQMVEVDRPDILIVEGLNVLQTGRPPRDGKAIPFVSDFFDFSVYIDADEDVLEHWYVQRFMRLRETAFKDPLSYFHRYSKLTEEEARETALSIWHRINLTNLRENILPTRQRANLILRKAGDHEVAEVQLRKL
Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 36973 Sequence Length: 320 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
P54556
MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEFLNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPRIFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV
Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 36640 Sequence Length: 319 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q89WM2
MDIRAPEQQYNPYRVYTREQWARLRDDTPMTLEPGEFDRLRSLHDRLDLQEVEDIYLPLSRLLSIYVDAMQRLYYAERQFLNIRDRKMPYIIGVAGSVAVGKSTTARVLQALLARWSPRPKVDLITTDGFLYPNAVLDRQGIMQKKGFPESYDLPLLLGFLSDIKAGRRHVRAPVYSHLTYDIVPNQWVEIDQPDILIVEGVNVLQTGKLPRDGKAVPVVSDFFDFSVYIDADEAALRRWYIKRFLALRDTAFTNPKSYFNRYALLSDEEATATAIAIWERTNLANLEDNILPTRPRATLILKKGPDHVVESVALRRL
Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 36712 Sequence Length: 318 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
A7HSG6
MGDDALTADSGRDETQSLSPFRYFTAAEWGRLRQDTPLPLSQGELEELKGFGERISLDEVSEIYLPLSRLLNLYVGETQELYRVTSDFLGREQDKVPYIIGVAGSVAVGKSTTARILRTLLARWPNHPKVDLITTDGFLYPNKVLEERGLMQRKGFPESFDIKRLLRFLSDVKAGSRHVEAPVYSHFTYDILPGETIPVDYPDILVVEGLNVLQPWKPADGDEPQPFVSDFFDFSIYLDADEASIRRWYIERFLSLRRTSFKDPAAYFHRYSKLTEEEAVETADAIWTSINLANLRKNILPTRQRADLILRKGDDHRIRDVLLRKL
Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 37414 Sequence Length: 326 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
B7GN19
MTIAVCPGSYDPVTAGHLDVIERSARFFDEVHVVVAVNAAKTPMFSDATRVDVIRRALDKAGCKNVTVSSTDGLITDYCKKVGATVIVKGLRQNGDYEAELGMALVNRKLAGIETLFLPADPILEHISSSIVKDVARHGGDVTGMVPDCVVPMLADALAEERQRKD
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 17810 Sequence Length: 166 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q491X2
MTIQAMYPGTFDPLTYGHLDIIIRAHKIFDKIFLAVAENSQKHPLFSLEERVIFAKQATAMLDYVTVFGFNDLTINVMKKKQVNILIRGLRNRSDFEYEIQLAKINNYFSNEVETVFMISTDIWACLSSKLVKEIAQYGGRIDHFIPNFIVEKVIEKLRNTEKKNKNISFL
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 19885 Sequence Length: 171 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
O51645
MRVAVFPGSFDPITWGHIDLIKRSLAIFDKVIVLVAKNKSKKYFLSDIERFSLTKDVISSLNFSNVLVDRYSGFIVDYALINSIKFIVRGIRAFNDFDIEFERYLVNNKLNFEIDTIFLPSSAEHLYVRSDFVKELMLKKDVDLSNFVPELVFNRLKSKFIDK
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 19016 Sequence Length: 163 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
C0R0Q0
MKNGKVIFPGTFDPFTLGHLDVLYRLADIFNKVYISVAVNLDKSPTFSIDERKNMIKKVIGDNDTIEIVTISGLVTEYMKQNDIKVLARGIRDSEDLYYELRMSRMNKLLYPEMDTIFLHTSEHYAYVSSSLIKEILKFNGPIDGLVPEILVEDIRSKFIKK
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 18671 Sequence Length: 162 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
A5EJR7
MQRIALYPGSFDPVTNGHLDVVRQAVHLCDRLIVAVGVHHGKKPLFSTEERLAMVHEVLEPVAAAAGCGFEASTYDDLTVTAAQKAGAIMMIRGLRDGTDFDYEMQLAGMNQTMVPGIQTVFVPASVAVRPIAATLVRQIAAMGGDVSHFVPAAVAASLKAKFN
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 17417 Sequence Length: 164 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q31EA3
MSITAVYPGTFDPITCGHFDLIERAARFYDRLVIAVADNRNKTALFSLEKRVALAKEVTADMPNVEVIGFSGLLVDFVREIDGNVLLRGLRAVSDFEYEFQLASMNRKLAPEVETMFMTPAEQYAFISSSLVREISALGGDVSEFVHPVVAKALNEKQL
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 17664 Sequence Length: 159 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
B2GFL8
MRRAICPGSFDPLHLGHCAVIRRATLLFDEVVVAVSTNPNKTHRFSEAQRIELVREVFADDPAVVVEPLESGLIADYAERRGAVALVKGLRNGADYDYELPMATMNRSLTGVETVFLPGEPSLLHVSSSLVMEVAALGGDVTSFVPPEVLRALEDE
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 16958 Sequence Length: 156 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
C5CFP6
MKAIYPGSFDPITYGHMDILKRASKIFDEVVVLVMKNINKRYFFTFSERLSMVEKAVEGIQNARADSYEGLLVDYARKAGIKIVVRGLRAISDFEMEIQVAHINKAMYADLETVFLMTDPKYSFLSSSIVREAASFGGDVSLWVPPYVEEALKRKFSGST
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 18095 Sequence Length: 160 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q5FKS7
MTIALFPGSFDPITNGHVETAKKAAQMFDKVFVVAMTNTSKKYLFTAEERTAFAKDALKNISNIEVLEKPEELTVKLAHELKANVIVRGVRNSADFLYEQEIAGINKRLAPDINTVLLFSSPDNSFVASSMIKELARFDEDVSQFLPIKAAKALRKKLRHE
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 18015 Sequence Length: 161 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q9CDQ6
MTEKIGLFTGTFDPLTNGHLDVIKRASQHFDQLYVGIFKNDQKNPLFPTDKRVEMLEEALTSLSVTHKVKVIKHERDLTVNIAKKLGVTALVRSLRNSQDLEYEKNMFYFNMEMTGIETIFFLAKPELEPLNSTRMRELHAFGQDVSAWVPENVSRELRKLDEKK
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 19128 Sequence Length: 165 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q88VC8
MVTAVFPGSFDPITRGHLDMIQRASRLVDRLIVAVMVNTSKQPLFTMTEKVAMISDELTGLPNVEVQAATGLTVDFMASVHATVLVRGLRNEQDFGYERDIAWMNKSLDETIETICLIARPPYAYFSSSLIKEVAKMGADVSKYVPTAVAQKLHQRLGTDQHD
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 18072 Sequence Length: 163 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q8E8I0
MHTRAIYPGTFDPITNGHADLIERAAKLFKHVIIGIAANPSKQPRFTLEERVELVNRVTAHLDNVEVVGFSGLLVDFAKEQRASVLVRGLRAVSDFEYEFQLANMNRRLSPDLESVFLTPAEENSFISSTLVKEVALHGGDVSQFVHPEVASALAAKLKLAKA
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 17951 Sequence Length: 163 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q2NQU5
MTNKAIYPGTFDPLTNGHLDLVTRAAKMFDVVVLAIAASPSKRPLFDLNERVALATQVTAHLPNVKVTGFSDLMADFARQQQANILIRGVRAMTDVDYEMPLAKMNRHLMPALETVFMLPAEAWSYISSTLVKEVALHGGDVDHFLPAPIAKEVRARLHP
Function: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Catalytic Activity: (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Sequence Mass (Da): 17662 Sequence Length: 160 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Subcellular Location: Cytoplasm EC: 2.7.7.3
Q8RBE5
MRVVGLTGGIGSGKSTVSGILAKLGAKIIDADLVSREIMEKGKEAYNEIVDCFGKEILDKEGNIDRKKLGSIVFSDKEKLKRLNEITHPKIIDKIKKMIEEEKDKDKVIVIDAALLIETGLYKLVDEVWLVVVDIDTQIKRVMERDGFSCEEALKRIKSQMPLEEKIKYADFIINNSKDLRKTEEQVRLLWQRFDRRSYFD
Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) Sequence Mass (Da): 23106 Sequence Length: 201 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Subcellular Location: Cytoplasm EC: 2.7.1.24
Q9PMD9
MKNAFFVTASIACGKSTFIEIANSLGFKSISADKIAHKILDENALELEKIFSPFSLKNLLKKEKKIDRKILGEIVFNNKEAKKILENFTHPKIRAKILEQMQILDKENKAFFVEIPLFFESGAYENLGKVIVIYTPKELSLKRIMQRDKLSLEAAKARLDSQIDIEEKLKKADFIIKNTNSYADFRQECVKVIQEISKGNM
Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) Sequence Mass (Da): 23048 Sequence Length: 201 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Subcellular Location: Cytoplasm EC: 2.7.1.24
Q3ABL6
MLVLPIIGLTGGIASGKSTVSRILQELGFAIIDADRIARDILTPGHPAYQKVIDTFGKNILTEDGQIDRAKLGKIVFGNREKLLVLNSITHPEVLKEIRKKIKELTSSGIDWIVLDIPLLFEAKMTSLVDEIWVVYVPEEEQLKRLMARNGFSRDEALARIRAQMPLEEKVKLADVVIDNSGSIESTREQILTILQKWKWKDWSKK
Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) Sequence Mass (Da): 23299 Sequence Length: 206 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Subcellular Location: Cytoplasm EC: 2.7.1.24
P58100
MLILGLTGSIGMGKSTTSKMFQDEGVPVYDADAAVHALYASGGAAVAPVETAFPGVVVDGAIDRAKLSAQVVGNSEALAKLEAIVHPLVGAHRIGFFEQAKAEGHEIVVLDIPLLFETGGEKRVDKVVVVSAPAEVQRERVLARPEMTPEKFEAILARQTPDADKRARADFVIDTGQGLDHARRQVRDLLTLLRTARSA
Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) Sequence Mass (Da): 21188 Sequence Length: 199 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Subcellular Location: Cytoplasm EC: 2.7.1.24
Q3B3J7
MTPSHPFLVGVTGGIGSGKSTLCRFLEKMGCELFEADKVARQLQVSDPEIMEGIKSLFGKDVYSKTRSGKLSLDRKRIAREVFSHPATLGALNNLIHPKVYNAFRQRALEAFGRGTAILVMEAAILFETGRAADLDFVVVVAADTETRIKRAVTRGLGTPEDIRKRIALQWPQEMLVARADYVVNNDIGKTKLKEEAGRLYSVLVEAAASGPDCQSKRR
Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) Sequence Mass (Da): 24093 Sequence Length: 219 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Subcellular Location: Cytoplasm EC: 2.7.1.24
Q9Z7U3
MLKLLKVSITGDLSSGKTEACQVFQELGAYVVSADEISHSFLIPHTRIGRRVIDLLGSDVVVDGAFDAQAIAAKVFYNSVLLQGLEAILHPEVCRIIEEQYHQSIQDGNYPLFVAEVPLLYEIHYAKWFDSVILVMANEDIRRERFMKKTGRSSEDFDQRCSRFLNVEEKLAQADVVVENNGTKKELHQKIEEYFYALKGAL
Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) Sequence Mass (Da): 22913 Sequence Length: 202 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Subcellular Location: Cytoplasm EC: 2.7.1.24
P37564
MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILRSLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV
Cofactor: Monovalent cations. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Cannot utilize a phosphoryl donor other than ATP. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 28576 Sequence Length: 258 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q89ZL1
MNLIIDIGNTTAKVALFNRSEMVEVLTESNQSLDSLEALCSKYRIERGIVATVVDLNERILAELAALPFPLLWLNHETPLPVGNLYETPETLGYDRIAAVVGANEQFPHNDILVIDAGTCITYEFIDSKGQYHGGNISPGMQMRYKALHQFTGRLPLIDSNGRKLPMGRDTETAIRAGVLKGMEYEISGYIEAMKHKYPELLVFLTGGDDFSFDSSVKSAIFADRFLVLKGLNRILNYNNGRI
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 27060 Sequence Length: 243 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q6MHI0
MILCLDVGNTQIYAGLFDKDKMVLSFRKNSKSGASSDETGIFLRTAIRENGFDPAKVKQIAICSVVPEVIYSLRGACMKYFNINPFILQAGVKTGLKIKYRNPLEVGADRIANSIAATHLHPGKNLILVDLGTATTFCAVSKDKDYLGGSIVAGLRLCMEALESKTAKLPSVEIVAMHEALGRATIESIQSGLYYGHLGTIKELTERITKECFQGERPMVIGTGGFSYLFEKEKVFDEIVPDLVLKGMLIALQHNA
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 27952 Sequence Length: 256 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
B8DTP8
MILAVDIGNTNIVIGLMEGTETVDTYRITTRSNHTSDEYGLMILQFLQLSNSSPDDVQDAIISSVVPKVMHSFISSMIKFLGIDPMIIGPGIKTGMNIRMDDPRSLGADLLADCAGAYTTYGGPVLVIDMGTATTYNYVDEKGAILAGLITTGIGTAAAALASNTAQLPEVQITRPKSILAANTKDAMQAGLYYDCLGGIERTITQFREELDTDFKVVATGGMSRIFDCPLIDIVDPTLIFKGMASIYAKNV
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 26948 Sequence Length: 252 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
O51477
MNKPLLSELIIDIGNTSIAFALFKDNQVNLFIKMKTNLMLRYDEVYSFFEENFDFNVNKVFISSVVPILNETFKNVIFSFFKIKPLFIGFDLNYDLTFNPYKSDKFLLGSDVFANLVAAIENYSFENVLVVDLGTACTIFAVSRQDGILGGIINSGPLINFNSLLDNAYLIKKFPISTPNNLLERTTSGSVNSGLFYQYKYLIEGVYRDIKQMYKKKFNLIITGGNADLILSLIEIEFIFNIHLTVEGVRILGNSIDFKFVN
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 29823 Sequence Length: 262 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q82S93
MNTSSLLLAVDSGNTAIKWGLHDGRQWLAHGKTLQSERRMLKQNWTALPAPASILIANVAGLQAADDLKALLAPWHVHLEWATASARQCGVISRYSNPAQLGCDRWVALIAAWHRLQQACLVVDVGTAMTVDALSASGEFLGGVIVPGPDAMRQALADRAGIFSMPLSGSFQNFPINTGNALYSGMIQALTGAVERMYDQLSEYTGKQMVVETILTGGGAALLAPHIHIPHQIVDDLVLEGLVIIAGAQAEIPATR
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 27261 Sequence Length: 256 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q2Y796
MNPLLLAVDSGNTRVKWGLHDGRNWLMQGVAAQGDRVQLEREWRDLREPSRVVISNVANAGVKGSLSELLAQWKAEPQWITAVPYQCGVRNYYSNPAQLGSDRWAALVAAWVLERQGCLVVDAGTAMTVDALSDTGEFLGGLITPGLDLMQKILVEDLGSLESEGGKFCDYPDSTADALYSGAVHAMAGAIERMAALLAGTLGHMPECILSGGAAQQLQPQLNVNVKVMDNLVLQGLLAIARETSETASGGVVASPEDSIEN
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 27916 Sequence Length: 262 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q3JEM4
MILLVDIGNSRIKWARLDGGKPADMGAVTRGKTGIKRVLSKAWKEFGDVNRVVVANVGGPKVAEQLEQWLQTHWQIAPEFLTARSNGYGIRNAYSKPETLGIDRWLGLVAVRQRYRGGDRKKAICIVDCGTAITLDVLAADGKHLGGLIIPGLAMMPKFLADHTAGINETTEAVEYSLLASTTSAAINAGALYGAVAFIDRVSHDVAVEMKGELKFVITGGDAPRILPLLRDKYEHLPDLVLRGLARVAKDTSKVRRETDLDCAAQ
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 28841 Sequence Length: 266 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
A1SDX1
MPLLCADIGNSHTVLGLVSGGSVLADWRVATDERNTADDWSVLLRGLLGAALEEIDGIAVCATVPAVLHEWREMLTRHFPAVRHVVVEPGVRTGVPVLMDNPREVGTDRIINALAAVHEYGGPAIVVDFGGTATTFDVVSAQGQYVGGSISPGIELSLESLGRRGAQLRKVELLRPRSVIAKNTVEALQSGMVFGVAAQVEGIVDRMIGELGVGATDVQVIATGYLAPVVLDECRCFTHHAPWLTLRGLELVFERNA
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 27360 Sequence Length: 257 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
B2JKK7
MSTPYLLIDAGNSRVKWALVQADGTQTHSGAFSHGGQLVKGTGDPLQSRHEPDWSALPAPGSAWLSNVAGDAVARRIDAFIDRHWPGLARTTVRSAAQQCGVTNAYTTPSQLGSDRWAGMIGARAAFPGEPLLIATFGTATTLEALTADGVFVGGLIAPGWSLMMRSLGEHTAQLPTLDSTAARGLLDGDNAAGQREPAERGAWFATDTPRSLSSGCALAQIGLIERMWRHLQDEWQVSVRLVVGGGAAGELVQALSVPYTRHDSLVLAGLALIAAQAPVYPSTHTRPV
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 30377 Sequence Length: 289 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q4FM76
MIIVGDIGNTETKICLVNSKNIIIKRVILLTKKINHSSLNKSLLGLNLKNKSINKCLFCSVVPKKFNAVKIFFKKVYKIKCHELKKLNLNKLIKIKVNYKQIGSDRLANAISIINNKDNFIILDFGTATTFDVLIKNTYHGGVIAPGVKLSLDTLTDKASQIPKINLKKTNRVIGLNTISAVRAGFFWGYEGLIDNIVNLIKKETKMSFKIIITGGFSGLFKNSIKTKVTLNKDITIKGLIRATTLIK
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 27648 Sequence Length: 248 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
C0QU76
MILGIDIGNTTSEFGFIYNGKRINSYKLRSDHTKTVDDWLIDISAIFSIEGMKKESVKDCVISSVVPPLEDRIYSACKKFLGKKPLRIGKELKVPIKINYKNPEEVGIDRVVNAFAGVKRYGKPLILVDLGTAITFDVVNQKGEYEGGAIFPGIDSSIEALFSKTAKLPKVSIENVKKVVGKTTVESIQSGIFFGYISLIEGMIKRIIREKGFSPKVILTGGSGEIITKGLEIDHIFDMYLSLEGIYDIYSYHGN
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 28255 Sequence Length: 255 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
A9BIX4
MELLFDVGNSYTMVGIHQDGKFLTWRIGPSSFESEDGLFVIISNLLNRVNVDLNKITLAGISSVVPNVNFILEQMLKKYFNVEIIFVGTKNKINNIAYLVDYPKEVGADRICNVIACKQEYGDNVIALDFGTAITVDVLEGGNFVGGAIIPGFKTAIGALFSRTAQLPKVEIKIPEYHLGKNTIDNIQIGVIKTTLYGIERLIDEIKRERNKDFVVVATGGDMSFLSSKISIFKHYDPYLTLKGILYYSKEIKKL
Cofactor: A monovalent cation. Ammonium or potassium. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Sequence Mass (Da): 28441 Sequence Length: 255 Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Subcellular Location: Cytoplasm EC: 2.7.1.33
Q97CS1
MIVVLIGALSIDIIFGEPKEYIHPVVFSGRVASAIEGYFRKFDNRFRAGILFSIAVIVLTAIPYFLAVYLSSFILVVYVVVSMVILKTTFSITSMGEHIKLITDSLKKGNIMEARMHLSMIVRRDTSRLNENEISSAAIESIAEGLVDGYITPLFFFVFFGLPGAFIARIINTLDSMYGYKDRKNFEFGRFSAFMDTVINYIPARISWFFITFSSDILNYRSKAIPVRRYIRRFDSVNAGWPIASMASALNLRLEKKGHYIVNDDGYQPGVADIEKSMKIYYLAAYSYIVIFVLPLLVIMAVFL
Function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 34484 Sequence Length: 304 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis. Subcellular Location: Cell membrane
P21636
MAEAGMRKILIIGIGSGNPEHMTVQAINALNCADVLFIPTKGAKKTELAEVRRDICARYVTRKDSRTVEFAVPVRRTEGVSYDGSVDDWHAQIAGIYEALLSKELGEEGTGAFLVWGDPMLYDSTIRIVERVKARGEVAFAYDVIPGITSLQALCASHRIPLNLVGKPVEITTGRRLHESFPEKSQTSVVMLDGEQAFQRVEDPEAEIYWGAYLGTRDEIVISGRVAEVKDRILETRAAARAKMGWIMDIYLLRKGADFDE
Function: Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. Catalytic Activity: H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine Sequence Mass (Da): 28945 Sequence Length: 261 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 5/10. EC: 2.1.1.152
P21637
MTDLMTSCALPLTGDAGTVASMRRGACPSLAEPMQTGDGLLVRVRPTDDSLTLPKVIALATAAERFGNGIIEITARGNLQLRGLSAASVPRLAQAIGDAEIAIAEGLAIEVPPLAGIDPDEIADPRPIATELREALDVRQVPLKLAPKLSVVIDSGGRFGLGAVVADIRLQAVSTVAGVAWVLSLGGTSTKASSVGTLAGNAVVPALITILEKLASLGTTMRGRDLDPSEIRALCRCETSSERPAAPRSAAIPGIHALGNADTVLGLGLAFAQVEAAALASYLHQVQALGANAIRLAPGHAFFVLGLCPETAAVAQSLAASHGFRIAEQDPRNAIATCAGSKGCASAWMETKGMAERLVETAPELLDGSLTVHLSGCAKGCARPKPSELTLVGAPSGYGLVVNGAANGLPSAYTDENGMGSALARLGRLVRQNKDAGESAQSCLTRLGAARVSAAFEQG
Function: Catalyzes the elimination of C-20 in precorrin-3A to form precorrin-3B. Catalytic Activity: 2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B Sequence Mass (Da): 46691 Sequence Length: 459 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10. EC: 1.14.13.83
P63840
MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVADPRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGGPVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE
Function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. Catalytic Activity: 3 H(+) + precorrin-8X = hydrogenobyrinate Sequence Mass (Da): 21614 Sequence Length: 208 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10. EC: 5.4.99.61
Q9HZU2
MIDYIRDGQAIYRQSFATIRAEANLAGIPADLEKLAVRVIHACGMVDVVDDLRFSPGAGAAGRAALAAGAAILCDARMVAEGVTRSRLPAANRVICTLNEADVPALATELGNTRSAVALEHWREHLEGSVVVIGNAPTALFYLLEMLDAGAPKPALILGFPVGFVGAAESKEMLAADSRGVPYVIVRGRRGGSAMAAAAVNALATERE
Function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. Catalytic Activity: 3 H(+) + precorrin-8X = hydrogenobyrinate Sequence Mass (Da): 21650 Sequence Length: 208 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10. EC: 5.4.99.61
P21638
MPEYDYIRDGNAIYERSFAIIRAEADLSRFSEEEADLAVRMVHACGSVEATRQFVFSPDFVSSARAALKAGAPILCDAEMVAHGVTRARLPAGNEVICTLRDPRTPALAAEIGNTRSAAALKLWSERLAGSVVAIGNAPTALFFLLEMLRDGAPKPAAILGMPVGFVGAAESKDALAENSYGVPFAIVRGRLGGSAMTAAALNSLARPGL
Function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. Catalytic Activity: 3 H(+) + precorrin-8X = hydrogenobyrinate Sequence Mass (Da): 22064 Sequence Length: 210 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 8/10. EC: 5.4.99.61
P66878
MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD
Function: Methylates precorrin-2 at the C-20 position to produce precorrin-3A. Catalytic Activity: precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine Sequence Mass (Da): 53911 Sequence Length: 508 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10.
Q9HZU3
MMSVVKGRLLGLGVGPGDPELITLKALRLLRAAPVVGYFVAKGKKGNAFGIIEAHLDQAQVRLPLVYPVTTEKLEPPLCYETIISDFYDTAAEQLAAHLDAGRDVAVICEGDPFFYGSYMYLHDRLATRYESEVVPGVCSMLGGAAVLGAPLVYRNQSLSVLSGVLPEEELRRRLADADAAVVMKLGRNFDKVRRVLVELGLERRALYVERATMANQRIVPLERVEPMASPYFSLIVVPGDKWQGGAGGE
Function: Methylates precorrin-2 at the C-20 position to produce precorrin-3A. Catalytic Activity: precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine Sequence Mass (Da): 27275 Sequence Length: 250 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10. EC: 2.1.1.130
P21639
MSGVGVGRLIGVGTGPGDPELLTVKAVKALGQADVLAYFAKAGRSGNGRAVVEGLLKPDLVELPLYYPVTTEIDKDDGAYKTQITDFYNASAEAVAAHLAAGRTVAVLSEGDPLFYGSYMHLHVRLANRFPVEVIPGITAMSGCWSLAGLPLVQGDDVLSVLPGTMAEAELGRRLADTEAAVIMKVGRNLPKIRRALAASGRLDQAVYVERGTMKNAAMTALAEKADDEAPYFSLVLVPGWKDRP
Function: Methylates precorrin-2 at the C-20 position to produce precorrin-3A. Catalytic Activity: precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine Sequence Mass (Da): 25895 Sequence Length: 245 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 1/10. EC: 2.1.1.130
P21640
MTGTLYVVGTGPGSAKQMTPETAEAVAAAQEFYGYFPYLDRLNLRPDQIRVASDNREELDRAQVALTRAAAGVKVCMVSGGDPGVFAMAAAVCEAIDKGPAEWKSVELVITPGVTAMLAVAARIGAPLGHDFCAISLSDNLKPWEVITRRLRLAAEAGFVIALYNPISKARPWQLGEAFELLRSVLPASVPVIFGRAAGRPDERIAVMPLGEADANRADMATCVIIGSPETRIVERDGQPDLVYTPRFYAGASQ
Function: Methyltransferase that catalyzes the methylation of C-17 in precorrin-3B to form precorrin-4. Catalytic Activity: precorrin-3B + S-adenosyl-L-methionine = 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine Sequence Mass (Da): 27105 Sequence Length: 254 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 3/10. EC: 2.1.1.131
P9WP88
MTRVLLLGGTAEGRALAKELHPHVEIVSSLAGRVPNPALPIGPVRIGGFGGVEGLRGWLREERIDAVVDATHPFAVTITAHAAQVCGELGLPYLVLARPPWDPGTAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFANSDAWFLIRVVTAPDGTALPRRHKLVLSRGPYGYHDEFALLREQRIDALVTKNSGGKMTRAKLDAAAALGISVVMIARPLLPAGVAAVDSVHRAAMWVAGLPSR
Function: Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. Catalytic Activity: NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A Sequence Mass (Da): 25737 Sequence Length: 244 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10. EC: 1.3.1.54
Q89Q75
MIPGTETIRNVIADLRIAASFVTLLPVGSSKPAADGAIARATWALPVAGLLVGLAGALVYKISSRLGLTPNLAALLALATTALITGALHEDGLADTADGLGGGRTRERKLEIMRDSRIGTYGVCALILSFGLRWSALAAIANPWLVTLALCAAHCAARAGVPAFMSLVPPARPDGLSASAGAPPGRSVAIAFAVGTLVLTLALGPGKALVGLILLSLAGLILARLAIRQIGGQTGDILGAFEQTGEIVILLVAAAFQMGR
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26251 Sequence Length: 260 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
C0Z7H6
MNAFLHAISFFTRIPVPWLRPSEEAWRKSVNWYPAVGLVIGLLLWGVHQAGLVLFSPWIAAILTLIAWVYVTGGLHMDGWMDLADGLGSSRPREQILAIMKDSRVGAMGVLAAIMLLLIKAGAVAELAHPGWGSFLIVAPVAARTHVLLSIKLWPYLSADKGIGKGISSGLSVSSIIVSYIIVFAAGWYLGGLQVMTAIFLSLLFALWFSRSVAKKLGGLNGDCYGAVIESSEAVVLLVLVGSWWL
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26515 Sequence Length: 246 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell membrane EC: 2.7.8.26
A6X1H1
MQRNSLIGDTIRSLGFLSRLPLPQRWFEDGDDSLPRNARAFPLAGAVLGLLAGAVLFMAYKVNLPPLACAMLAIGALAAMTGALHEDGLGDTADGFFGASSPDRRLDIMKDSRIGTFAALTLIVFVGLKAALLMTIIDRAGAGYAALALVGCEAASRSGMLAFWHALPSARPGGLSDSVGQPQWETVVCGFGIGLAFLVFTLIPAGGFLSLINALVLATGLLFGFARLCIAKIGGQTGDTLGAAQQIGSVAVLAGLVMAL
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26734 Sequence Length: 260 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
Q8RCN8
MEELKALILSIQFMTGIPIPINIDVKEDKIYKIASYFPVVGLLIGGILYIAYLLLKDLFSREIVMTFLVAFSYILTRGMHIDGLADTFDGLFSNKDREKIIEIMKDSRLGTNGVLALVFMVILKILFLSDIRQSLLFSALLVSPVIARLSVVFSIAISKSARGGKGLGGLLLERAGLREFVIALLISTIAGYFVMPLKDLALLYVISLSFTCLISKYISKKIGGMTGDTLGAVNEFVELIAFIYFSIL
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 27351 Sequence Length: 248 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell membrane EC: 2.7.8.26
Q3AE01
MLTTFLLGLTFFTRIPVPGKLNFSEEKFNRAPIFLPAYGLVTGGILALIIELFGRSFPGFFWAGVIIAGQIYLSGALHIDGLLDSLDAIYSNRDREKRLEILKDSRVGSMAVAFFGAFLILKYGSYASFTPKVQAFTVLISEIILRGTGYLVIYSFPYVGSSLGRGFKDNASTAGLIFTLGQTLIFTLGAAAFFNFSLIKILIILLLAYLFAFVVAARWQQFFGGLTGDNYGGIMELTGLFVPVAVLLINNIGVV
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 27809 Sequence Length: 255 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell membrane EC: 2.7.8.26
Q8KDU6
MLSGLVTALRTLTALPVPGRDAERFSSSLYWFPVVGLVIGGIVVLLARAGMGVGWPELAAVLALLGGLILTRGLHADGLADLADGFFGGRTREAALRIMKDPNVGSFGSLALIGVMLFKWICLLELARAEAYGMIAAGAVLSRTAQVLLAARMPYARSDGGTAMAFVEDAGWPHLLVASISGVVLLFVLLDWQLAPSLILLFGSVVALFFVGWLSHRKIGGITGDVLGACSELVEAAVWLLAALWLKGLFWAIA
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26727 Sequence Length: 254 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
B0KCS0
MEEIKRLVLAMQFMTRLPIPIEIDVEKREFYRIASYFPIVGIVIGGILSLLYIALKDFFSREIVMTFIVAFSYVLTGAMHIDGLADTFDGLFSNKDKSKMLEIMRDSRLGTNGVLAAIFIVVLKILFLTNIHENITLTALLITPIIGRLSIVFSMMISKSARGGEGLGGLMLGKVGIREFAIAFVISIATSYFILPLAVFVKILTISLFVTYIVSKYISLRIGGMTGDTLGAVNELAELTALICFVSVSL
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 27523 Sequence Length: 250 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell membrane EC: 2.7.8.26
Q8DJ91
MKSLWQEWLGAIAFYTCLPISPRWPIQLAGAAKWCPWVGLVLGGMLWGVQWLLDFLQVPSPVASAVLVALWLALTGGLHLDGAMDTADGLAVRDQQRRLEVMADSRAGAFGVMAAMVILLLKVTSLSSLEKGSVLVWVLVLGRLAQVWAIARYPYLKPQGTGQIHKTSGVFPRDFWPSGLLVLLLSFLLPLPLGQLLFGLLLILLIPAWFQSQLGGHTGDSYGAVVEWTEALLLVAFTVGSAS
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26329 Sequence Length: 243 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
Q97BG1
MMISGLRSSFSFFTLVPSRQKDIGNPITFLPLVVTVGALIGDSILYITWQFSHLIASFLSISSIIIYNGLNHFDATADLGDALMVRDKSRIPEVIKDHHVGAGGIFAVIFVYGIAVLSLARSTLYIGLVGILIGQVVSGSSMMISLIGSQPFVPGLADYFISLFRKHSVGYTIEFLAIPIIVSFIFSPLYVVIVALNLLIVQLTKTMISRRFGGINGDVIGFLGEFSRSLFIFMLIIIAHYNVASTYDIFSKMLSSFTS
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 28310 Sequence Length: 259 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell membrane EC: 2.7.8.26
B5YL84
MINRFLIALSFLTVLPLKFKEINEKELIRSIIFFPFIGFLEGVFCIFLVNIFKQIFSSSVISIILLVFLFSVRGIFHIDGLSDTFDALFYKGTGQKEKDLQQRLQIMKDSVIGVAGAVALVLDVLCRFAFVKELIDINQFLIFLFMFCFSRWIVIPLMYYGKPARTTGLGVLFIGKISSWQVIISTVLPIFLLVYFTIEKNFIFLPLIALFLFFISYILKKFFERKFNGITGDHLGATVEITEIVFLICFLLGEKLWLSY
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 29998 Sequence Length: 260 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
Q3SFE7
MRGLILALGFLTRLPLPVLRDFQCAELVRAVVWFPAAGLVVGAAVALAAALGTVLDPWLGALAGVVMWAWITGGLHLDGLADTADALGAAHRDPARFLTVLADPHVGSFGVIVLVLQLAAKLVLLHWLLTLDLPWPALVLIPAWTRWAAAGWTLLLPPLKPGLGERFAWQGNRAGWGAGGLALAAVSAITPIAFVALIPAVLWGVWMWLKLGGQTGDILGAGIEWSESAALLLAGVSLALARGIIAG
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 25699 Sequence Length: 247 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
Q73K39
MKGFILALQFFTRIPININIDFNEKNIKRAFYFLPLIGGLIAGLVLIPIYFLPQKYIEISGFISLLLYLFLTGSIHLDGVGDTIDGFFSARKKEKILEIMQDPRIGTYGTIGLNVFLLLRYINYSTIIPDAGLLILAGIISRLSGLAVVVFSKPAKDTGLGLLFHKSASKFSFFFWLVLVCFLSLFTPEIAAFSKIQGTFILVERLKYLLLPLTAFILTFIIIRISYKKIGGITGDVNGLIVELTELAVLSTSFFINVHL
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 29031 Sequence Length: 260 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
A5F1U5
MAAILRYQLELFLLAVSFFSRIPVPVSLPYSSERMNQAGRYFALVGLLLGAICALVYSLATQLFSTNISVFLTMVLSLLLTGAFHEDGLADMADGVGGGMTAERRLEIMKDSRIGTYGSSALIMVLLGKYLLLTELADLTSLVPVWLLAYTLSRAVAASLIRNTPYVSDTDSSKSKPLAQQLSGTDVAVLSLTALATLLYFSWQFIGVMIAASLIFRQIFRQWLIRRLGGFTGDCLGAAQQLMEILIYLILLAFLQHEVMI
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 28593 Sequence Length: 261 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
Q8D922
MKTWQYQYQLFCLAVSFFSRLPVPKSTPYSDERMNQAGRYFALVGTLLGLLCVLVYAFASLFFPYQVAIVLMMAFSLLLTGAFHEDGLTDMADGIGGGMTLDKRLTIMKDSRIGTYGSATLTMALIGKFVFLTTLARQPDFGLMIVVAYTLSRAVAATLIYDMPYVSDSDTSKSKPLANAQSSTELAILILTGVLAAISLGLGVGLLLILFAILFRWAFKRWLLARLGGFTGDCLGGAQQLMELGIYLVLIAVVQ
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 27797 Sequence Length: 255 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
A7IB66
MQLDRIAQDLVAALRFYSRLPLPAGRDDPDAFAVPSLNRIAYAIPLAGAVIGLIGAVVLVGALALKLPAFLASVLAVTALVLTTGAFHEDGLADTADGLGGGRDKAQRLAIMRDSRIGTYGGCALILALLLRVAALEALVASAGMFRAALALVVAEAASRAAGVLLLLALPPARADGAGASFGRPSESAGLACALVAALLVVVILVPGFGISTAFAGLIAPLVALFAMMRLSGRLIGGQTGDVAGATQQVAVIVFLLGVLIFPGR
Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. Catalytic Activity: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26639 Sequence Length: 265 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Subcellular Location: Cell inner membrane EC: 2.7.8.26
A3DF00
MLFQTLKSIGELYKEPMDMVQRRLDSLSKPLGSLGRLEDIIKKLAGITGEVFPCVDKKAVIIMCADNGVVEEGISSCPKDVTSKVTRNFLKGITAINAFAKHTGSDIVVVDIGVDDDMDCEGIVKRKVRKGTWNIAKGPAMTRKEAIEAIEVGISIVEELGRKGVNLLGTGEMGIGNTTTSSAVSTVLTDSKAENMVGRGAGLSDEALKRKISIVKKAIDLNRPDANDPIDVVSKVGGFDIAGLAGCFIGAAACRIPILIDGFISATAALAAVRMEPKVKNFIFPSHGSAEPGSKKVMEALGFEPILNLEMRVGEGTGAALAFHIFDCAVSVYRNMGTFEDACIEQYQPQV
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Catalytic Activity: 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate Sequence Mass (Da): 37352 Sequence Length: 351 Pathway: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. EC: 2.4.2.21
A6TKH4
MNKLKETIRMIEELDQETMQKARERVDNLIKPPKSLGRLEDLAVQLAGITKTIHPTVANKAIIVMAADHGVYEEGIAGFPQEITVVQTLNFVKGVTGVCALGKVSGTKIIPVDIGVKEDLDPNAGVLIRKIKYGTDNMAKGPAMSREEAIRALEVGIEVANEEIKNGVTLLGTGEMGIGNTTASTAILSVLGNFDPKEITGRGAGLSPEGIQRKAAVIKRAIEVNQPDATDGIDVVAKVGGLEIAGMAGVMLAAAANRIPVVVDGYIATAAALIAVSLEPKTKQYLIPSHASAEIGSIKATELLGIKPMIHMDLCLGEGSGAALVFPIVEAACHMINCMPTFEEAGITI
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Catalytic Activity: 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate Sequence Mass (Da): 36603 Sequence Length: 349 Pathway: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. EC: 2.4.2.21
Q82AM7
MSSLNLDDFSDLIERPDGGVRRDAEARRERQIVPPGSLGRLDDLGEWLAAAQSAVPVRPVERPRVVLFAGDHGVASLGVSARPAGSADQLVRAVLEGASPASILARRLNVPVRVVDMALDCEPDALPESVVRHRVRRGSGRIDVEDALTLEEAEAAFRAGVAVADEEADAGTDLVVLGDVSVGGTTAAAVLIAALCGTDASVVTGRGGLAIDDLAWMRKCAAVRDALRRARPVLGDQLQLLAAVGGADLAAMTGFLLQSAARKTPVILDGVVSAACALVGQRIAFRAPDWWLAGQNSGEPAQAKALDRMALEPLLNHGVTVGEGAGALLALPLVQAAAALAAELPEKPEELEAGEGPEAAEESSPEPENPEALAE
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Catalytic Activity: 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate Sequence Mass (Da): 38743 Sequence Length: 375 Pathway: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. EC: 2.4.2.21
A0LF21
MEKLDRLLERIEPASKDWEAKAWERLHAQIRPRDSLGRLEVIAARLAAIKRSLTPAVGRKIIFTMAGDHGVAAEGVSAYPQEVTAQMVGSFVRGWASINILAVHCGAAVRVVDCGVASDLPPDWPVLRRKLGKGTANIAVGPAMSREVAVRGLTIGAEIVQDAHLKEGYLLFGTGDMGIGNTTPSTAIIAALGGKPVRDLTGRGTGIDDVAFERKVRVIERALAVNRPDPNDPLGVLAGVGGFEIAALGGAVLGAAALRVPIICDGFIATAGALVACRLAPKAADYLFVSHRSREVGHTAMVDMLGMRPILDLDMRLGEGTGSALAMNIVEAAAKVLVECKTFEEAGVTDTGH
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Catalytic Activity: 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate Sequence Mass (Da): 37072 Sequence Length: 353 Pathway: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. EC: 2.4.2.21
Q7SIC7
MDPEVFAQARLRMDQLTKPPRALGYLEEVALRLAALQGRVKPELGRGAVVVAAADHGVVAEGVSAYPQEVTRQMVLNFLRGGAAINQFALAADCAVYVLDVGVVGELPDHPGLLKRKVRPGTANLAQGPAMTPEEAERALLAGREAARRAIAEGATLLAAGDMGIGNTTAAAALTAALLGLPPEAVVGRGTGVGEEGLRRKRQAVARALARLHPGMGPLEVAAEVGGLELVAIAGIYLEGYEAGLPLVLDGFPVTAGALLAWKMAPGLRDHLFAGHLSREPGHRHQLEALGLRPLLDLDLALGEGTGAVLAMPLLRAAARILHMATFQEAGVSRG
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Catalytic Activity: 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate Sequence Mass (Da): 34747 Sequence Length: 335 Pathway: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. EC: 2.4.2.21
C5CKN8
MTDSNQTIPSISDIHDGALAARLQSALDNKTKPLGALGRLESLALRIGLVLGSETPVLEAPQMLVCAADHGLAARGVSAFPSDVTWQMVENFLAGGAAVSVLALQHGLALTVVDCGVRRDFQARPGLVSRRIAAGTADASAGPAMTAEQCAQAIANGREVVRALPGNALLLGEMGIGNSSAAALLLARLAGLDIDGCTGSGTGLDAAGLARKREVLRDVLALHAAASEPLDALAAFGGFEIATLVGAVLQAAQERRVIVIDGFIASAAVLVAQALQPHVAQRCVAAHSSAEPGHALLLKHLGLEPLLNLDLRLGEGSGGALAWPLLESACRILREMASFEAAGVSRKDS
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Catalytic Activity: 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate Sequence Mass (Da): 35615 Sequence Length: 349 Pathway: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. EC: 2.4.2.21
Q9KSL9
MLDRSFSAEIQQRIDQKTKPLGALGQLERVAHHLALIQSQNQDQAVTQLAIHQPTVLVFAADHGIAAQGVSIAPSAVTEQMVQNFLAGGAAINCFCRTEHAAMRVIDCGILRAQPAHADLIEQRLGAGTHNLAEQAAMSSEQVQEGIALGKALIHREVESGCNLLMFGEMGIGNTSSAAAILAALSGLPIEVCVGRGTGITDEQYQRKRALVTQGVERCLGAAPQDVLQQVGGFEIVQMVGAFMGAYEKQTPVLVDGFIVTVAAYVATLIEPNVRDFLLFAHCSQETGHRAVLEMLAAEPLLDLGLRLGEGTGAVLALGLVRAAVEFYNHMASFADAGVTV
Function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Catalytic Activity: 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate Sequence Mass (Da): 36084 Sequence Length: 341 Pathway: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. EC: 2.4.2.21