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Q8KF55
MLIIPAIDIKEGKCVRLTRGDFAQKKIYLDNPCDMAVIWRKQNAKMIHVVDLDAALTGETVNFERIREIVNVLDIPIQVGGGIRSVEAVEKYLDIGVSRVVIGSAAVTNPGLIADLLKKYRPSQIVVGIDAEHGVPKIKGWTESSNMQDYELAGEMKKLGVERIIYTDITRDGMLQGVGYETTKRFAEKAGMKVTASGGATTSDDLHKLRSLEKYGVDSVIIGKALYECNFPCQELWYAYEQGLGIDGEFSTARKKECCS
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 28711 Sequence Length: 260 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q7P0F0
MLLIPAIDLKDGQCVRLRQGAMDDATIFSDDPVKVAAHWRDQGARRLHLVDLNGAFAGKPKNLAVIRDILGEVGEDMPVQLGGGIRDLDTIEAYLDMGLAYVIIGTAAVKTPGFLHDACDAFPGQVIVGLDAKDGMVAIDGWAKITNHNVIDLAKRFEDYGVNSVIYTDIGRDGMMTGVNIEATVKLAQALTIPVIASGGLTNLDDIRALCAVEDEGIEGAITGRAIYEGSIDFAAAQTLADELAG
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 26034 Sequence Length: 246 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q97KH9
MIILPAIDIKQGKCVRLYQGRFEKSSVVAESPALTAKSFENDGAKYIHVVDLDGALEGEIINLDAVKSIVQVTSVPIELGGGIRNIKVVEKLINIGVKRIILGTAALKDKEFTREAIKEYGKSIAVGIDAKDGYVAVNGWLNVSKINYIEFAKIMEDMGTEDIILTDISKDGTLKGPNFDMLKKLQENVNCNITASGGIKDLDDLIKLKEMNIYGAIVGKAIYSEKINLKEAIAVIEKR
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 26112 Sequence Length: 239 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q1D4M2
MIAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSNADAIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFPGRVVVAADVKGREVVTRGWTAGSHRDIREVLAAFEPLPLGGLLVTAVHKEGQLSGVDLPLMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLDASAVAREFAG
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 25158 Sequence Length: 238 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q3IT10
MFPSFEVIPAVDMQDGQVVQLVGGERGTETEYGDPVAAAQRWVDAGAETLHLVDLDGAFEGERANADAVEAVLEATDVSVQLGGGIRTVDDADSLLSMGVDRVILGTAAVENPDIVGEINDRHPGSVVVSLDAKDGEVVVSGWTESTGLDPAEAAARYEAEGAGGVLFTDVDVEGQLSGVRADEIARVVDAVDIPVIASGGVSTLSDIEALKDAGAAATVVGTALYEGEFTLEEAAAVV
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 24424 Sequence Length: 239 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q7RXQ8
MTRFRPCIDLHAGQVKQIVGGTLDSATSELRTNFVSPHPPAYFAKLYRDNDLSGAHVIMLGPGNKEAALESLKAWPGGLQVGGGITDANAREWVEAGAEKVIITSYLFPNGKFSQSHLDAVLAALDGDKSKLVIDLSCRRQGDDRWFVAMNKWQTITDMEVSEESIKALEPYCSEFLIHAADNEGLQKGIDEKLVQRLSEWCSIPVTYAGGGRNLEDLETVKRLSGGKVDLTIGSALDCFGGKGVTLQECVEWNRRQ
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 28142 Sequence Length: 257 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
A9A5X1
MKIIPAIDLMDGQVVRLYKGDPKQKTVYSDDPVSVAKKWQKAGADMLHIVDLDATIGTGSNLDLIEKISKELSIPVEVAGGLRNEEIIDRAISFSNRVVIGTMAFKDKEMLQRIAKKYDFSKIVISVDHIDGFIVTHGWQESTKTPLLDAINEFVSMGFTEFLLTNVSKDGTLEGPDLEYLEKACAVQNANVIASGGISNIDDVSDVQRKNAFAVILGKALYENKISIEEAKQLVN
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 25960 Sequence Length: 236 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
A6Q4V9
MEILPAIDLKDGKAVRLTKGLMESAKIYSDEPWQVAKRFEEMGSRWLHLVDLNGAFAGEPKNLEQIKKIRANTSLKIELGGGIRDEETIRKYIDLGIERLILGSIAVKNPQFVKAMAAKYPIAVGIDAIDGFVAVEGWAKTSTMRATDLAREFAKSGVQAIICTDVGKDGTLSGVNVDFTVSIAEASGIDTIASGGVRDIEDIKKLQATGTVAGVIVGKAFYEGTLDLEEAFRLVQNG
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 25645 Sequence Length: 238 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q970Z2
MLKVVPSIDISEGKAVKRIRGVKGSGLILGNPVKIAYEIYEEGYDYLHVVDLDSAEENGNNEEYVKDICKIGFKWVQVGGGIRNVEKAERLLDYDCSAIVISTLPIKDPKSFMDIQKIIGKDKILLSVDYDSSGYVLIRGWKEKSIKVLDFLLSYDSLGYIFTYVENEGTKRGIDNNVKNYVIRIKGLKEYAGGIGSIEDLYKLNEYGINYAIIGMSFYSGSLRGIKYVY
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 25878 Sequence Length: 230 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q67KH9
MRLDLYPAIDLKDGQVVRLRQGRMDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQNAAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALGVSRAIIGTSALEGDVAARAVARFGPDRVAVSIDARGGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATDGMLTGPNFAELEMMGRTGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRALYTGAVDLAEALSLCGETRDT
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 26416 Sequence Length: 249 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q2LVE9
MVIIPAIDLKGGKCVRLLQGDFERVTVYSDHPVEMAKAWREKGAERLHLVDLDGSIAGNPRNAAIISQIVKSVGVPVEIGGGIRDISTIQRYLDMGVQWVILGTAALKDRSFVYNACDLFPGHVILGIDANNGKVAVEGWTEQSAITALELAISYENRGIAAVIYTDISRDGMQTGVNVEGTRVLAEAVDIPVIASGGVATLDDIKRLLPLEESGIAGVIIGKALYSGAIALEEAISLAKSS
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 25636 Sequence Length: 242 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q3AYT2
MEIIPAIDLLDGACVRLHQGDYDQVTRFSDDPVAQALSWQSQGAKRLHLVDLDGAKRGEPANDAAVRAIANALDIPVQLGGGVRSIERAEDLLNCGLERVILGTVAIEQPDLVQVLAERHPGSVVVGIDANKGKVATRGWLEQSDVLATDLARRFSDSGIAAIITTDIATDGTLAGPNLDALREMAQASSVPVIASGGIGCMADLLSLLPLEDQGVSGVIVGRALYDGRIDLAEAIGAIGDDRLQDITCGSTDLA
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 26606 Sequence Length: 255 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
Q0AW40
MIIYPAIDLKDGQCVRLVQGRVENKTVYSDAPANVARSFQEQGASFLHIVDLDGAFQGSPQNLKAIEAIAAAIDISFQVGGGLRQLSDVEKLLALGASRVIIGTRAVSHPDFIANLLDKFGPERIVLGLDAKEGMVAVEGWVSTSSVSAIDFGLQMKALGIQTAIYTDVSRDGLLQGPNLAAIKEMASSTGLDIIASGGVSSLDNIRALKELENDGVSGAIIGKALYDGKIGLVDALREAESKF
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 25656 Sequence Length: 244 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
P74561
MKILPAIDLLGGKCVRLYQGDYDQSQVYHEDPVEVARQWQAQGASRLHLVDLDGAKEGQPVNLTAIANIVEALTIPVQVGGGLRDRNRVKQLLDLGVGRVILGTIAVENPDLVGELCAEFPGQIVVGIDARNGKVATRGWLETSTVEAGELAQRMEKLGAAAIIYTDIHRDGTMQGPNLDALRQLASQLTIPVIASGGVSQVEDLLNLLSLESLGVNGVIIGKALYTGDIQLAEAIRAVGNGRWQDVPPLDFPRLG
Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 27350 Sequence Length: 256 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Subcellular Location: Cytoplasm EC: 5.3.1.16
P44340
MINITIIDTGCANLSSVKFAFDRLGYNTEITFDLNKIKSADKLILPGVGTANAAMYNLQERQLIETIQNLTQPVLGICLGMQLMTEFSEEGNVPTLNLISGKTNRIPDTGLPLPQMGWNRVQFVKNCPLFDGIVQNSHFYFVHSYAVSPNEHSVAISNYGVNFSAAIAKENFYGVQFHPERSGKNGALLLKNFVEKVPF
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 22048 Sequence Length: 199 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q9K6Z4
MLGIIDYGMGNLHSVSKALERLSWSYIVSEQPEELQKADGLILPGVGSFHDAMSILNETGLTAFIKDWVDEGKPLLGICLGMQLLFEESEENKRTKGLSLLPGRVIRFPGVATDGSTYKVPHMGWNQLTFRKPNHPLLTDVEEGHVYFVHSYVVKTDADDVLLATSHYYETVPAVVGRGNILGTQFHPEKSSNVGMSILRNYGAMVEKGVKARG
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 23603 Sequence Length: 214 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q5UYV3
MSVRQTTADVVVVDYGLGNLRSVTRGLERAGANVSLSEDPAEFDAADGIVLPGVGAFSEGMDNAGPFREALVEQAEAGKPLFGICLGMQMLLTTSEEADHEGQGDAEGLDLIPGKNVRFSRDQTVPHMGWNELDVTRDHPLVEGVDSVGSKTPRADGTGGSVDGEHAYFVHSYYAVPDDESATVATTDYGTDFASIVANDAGNVFGTQFHPEKSGETGLRILRNYVDYCLDH
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 24699 Sequence Length: 232 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q7VIW9
MSKLRVGIINYGVGNLGSVQNAFAFIQTHFSDVLPHTLEIKVESHPERLQDYDKLLLPGVGAFGNAMTHLKNTHLDEAIREFVQSGKFLIGICLGMQLLFEQSEEFGNHKGLGLIEGKVVGFEHIAPLKVPHIGWNSCNFTPEGKHSKLFRGIADGSFFYFVHSFHIQTQPQFILAQCTYGYPFGAIVHKDNLFAIQAHPEKSHNVGLRLLANFLTL
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 24227 Sequence Length: 217 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q31E66
MTDQKLVTVIDYGMGNLRSVAKAAEHAADSNTRICISDKAEDIRSADAIIFPGQGAAKACMKALNETNITHALIQAATEKPFLGICMGLQVLMTHSQENEGVDCLDILKGDVQKFDLSGHPELKMPHMGWNQIHQTIDHPLWHNIEQNSRFYFVHSYFVSPHDKQIIAGETTHGKRFTSAIAQNNLFAIQAHPEKSADAGLQLFKNFLNWNGQ
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 23666 Sequence Length: 213 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q02132
MKKIVIIDYNIGNLQSVQAAFLRLGQETVISRDLEEIRKADALILPGVGAFPTAMNNLKKFNLIELIQERAAAGIPILGICLGMQVLFEKGYEIEERQGLGLLKGEVIPIKTNEKIPHMGWNQLNLAKASPTTHYLSDNDEVYFVHSYQATCPDDELIAYTTYGEVKIPAIVGKNNVIGCQFHPEKSGEIGRKVLKAFLEEI
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 22454 Sequence Length: 202 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q88UE1
MFAIVDYDTGNTRNLKKAFDYLQVSTILTADPQQLAAADAVILPGVGAFAAAMAALKERQLVGVLQALARSGKPVLGICLGMQLLFESSSEYGEHAGLGLLSGRVSALPTDLNVKVPQMGWNQNELRRPDSPFASIDAAYTYFVHSYYAVCPATEIVATVQHGVQVPSIVQQQNVIGMQFHPEKSGRVGLQQLAAFKEMVSANDFSSN
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 22347 Sequence Length: 208 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q9ZGM1
MIGILDYGVGNLKAFANVLKGLNFHHQIVKTEQELKGCEKIIMPGVGSFDSVMNKLIESGIRDVLSDLIINKKIPILGVCVGMQILASSSEEGSKSGLGWIRGRVKKFNFDRSDFSLTIPQIGWNEVNSTKENTLLKNLEKNPRFYFLHSYYIECEDKKDVIAIANYGGDFTCAVNRENIYGTQFHPEKSHHNGVALIRNFASL
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 22841 Sequence Length: 204 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
P61780
MIAILDYGMGNIHSCLKAVSLYTKDFVFTKDHSTIENSKALILPGDGHFDKAMENLNSTGLRKTIDKHVTSGKPLFGICIGFQILFESSEEIAQGSKKEQIEGLGYIKGKIKKFHGKDFKVPHIGWNRLQIRRKDKSVLLKGIGDQSFFYFIHSYRPTDAEGNAITGLCDYYQEKFPAVVEKNNIFGTQFHPEKSHTHGLKLLENFIRFI
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 23829 Sequence Length: 210 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q8Y9G5
MLTKRIIPCLDVTAGRVVKGVNFVSLTDVGDPVEIAKAYNEAGADELVFLDITATVELRQTMIDVVERTAEQVFIPLTVGGGISSVSDMKELLQAGADKISLNSAAIKRPELIQEGAAKFGNQCIVVAIDAKWNGTNWSVFTRGGRNDTGLDAIEWAKKAVQLGAGEILLTSMDGDGTKNGYDIPLTKAISEAVSVPVIASGGCGNAAHMVEVFEKTKATAALAASIFHYGELSIKNVKTTLLEKGVNIRP
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 26533 Sequence Length: 251 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q8DTR3
MLKKRIIPCLDVKDGRVVKGVNFVNLTDVGDPVDAARAYYEAGCDELVFLDITATSDNRETTVDMVRHVADQVFIPFTVGGGIRSVDDMNKMLKAGADKVAVNSSAIANPQLIKDCAEKFGSQCVVVAIDARKEADDSWHVYVAGGRKDTGIDLLAWVKEAVQLGAGEILLTSMDKDGTKSGFDLDMLNAVAQLADIPIIASGGAGNMEHMVEIFEKTPATGALAASIFHYGEVSIADTKKAMKEHGIEVR
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 26874 Sequence Length: 251 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q4J8I9
MTSKRIIPCLDVKDGRVVKGVNFLNLVDKGDPVELAARYEEEGADEIVFLDITATIEGRKTMMNVVKDTASVISIPLTVGGGIRSLDDVSKILGNGADKVSINTAAVENKDLVSISSAEFGSQAIVVAIDVKRIGNDYYVFTRSGKYNTGINAISWAKEVEKLGAGEILLTSIDRDGTREGYDIEITELISKSVNIPIIASGGAGKIDDFLGILKVADAALAAGVFHDGVIRIMDLKKYLGKNGVEVRM
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 26607 Sequence Length: 249 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
Q30NR6
MNYFAKRIIPCLDVKDGRVVKGVNFVGLRDAGDPVEVAKRYNQEGADEITFLDITASSDNRDTIVDIVAQVAREIFIPLTVGGGIRKLEDIYRLLNVGCDKVSVNSAAIKRPQLIDESAKRFGSQCIVTAIDVKKTGDRYNVYLNGGRVDTGIDALEWAKEVVERGSGEILLTSMDADGTKAGFELSITQLISEAVNVPVIASGGAGTMKHIKEAFEHGADAALAATIFHYREIDIMDLKRYLHDNNIPVRL
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. Catalytic Activity: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate Sequence Mass (Da): 27539 Sequence Length: 252 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Subcellular Location: Cytoplasm EC: 4.3.2.10
A0RZ75
MRKNESQRETKETEVSVSVLLDGTGSTTVNTGQPFLDHLVSSLGKHAMFDIDLKASSRDGIVHHLVEDVAITLGGAIDKALGDRSGIMRFGHASVPLDESLSEAVVDLVKRPYHRIEMKIKRPEVEGIAKEDLEHFFDSLLRNLDCCIHLTVKYGNNDHHRVESAIKSLAVALRMAVSADPRREGPPSTKGSM
Catalytic Activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Sequence Mass (Da): 21221 Sequence Length: 193 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. Subcellular Location: Cytoplasm EC: 4.2.1.19
O33564
MRKAEISRKTAETDISVTVDLDGTGRYDIRTGVGFFDHMMDQLARHALIDITLRCEGDLHIDDHHTVEDCGIALGQALTRALGDKRGIRRYGSFHLAMDDALVRAALDLSGRPFLVWNLPFPTEKIGSFDTELVREFFQALATHGGITLHVDLIHGVNSHHIAEAAFKAVARSLREAVEPDPRRADAIPSTKGML
Catalytic Activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Sequence Mass (Da): 21565 Sequence Length: 195 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. Subcellular Location: Cytoplasm EC: 4.2.1.19
A9WDZ1
MSEVSSVVNRIRRATIERVTGETNITLTLTIDGSGQADVQTGIGFLDHMLTLWARHGLFDLQVRAQGDLHIDEHHTAEDVCICLGRAIDQALGERAGIVRTAHSFVPMDEALALVAVDLGGRPYCVVQADFVTMRVGQLGTDLVAHLFESVAFNGRFNLHAQVMYGRNDHHKIEALFKAFGRALDAATRIDARLGGTIPSTKGVL
Catalytic Activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Sequence Mass (Da): 22299 Sequence Length: 205 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. Subcellular Location: Cytoplasm EC: 4.2.1.19
A1ATG7
MTRTATIERNTSETRIRLTLNIDGRGETSIGSGVPFLDHMLNLFARHGLFDLSLEACGDTQIDFHHTVEDIGIVLGEAFKQALADKQGINRYGQVTVPMDETLASAVVDISGRPYLVYNVDLPKAKVGDFDVELAQEFFQAFANHCGINLHINLLYGDNLHHIIEACFKAVGRAMDMATRLDPRVEGVMSTKGVL
Catalytic Activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Sequence Mass (Da): 21504 Sequence Length: 195 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. Subcellular Location: Cytoplasm EC: 4.2.1.19
Q4FNT4
MNRIGKVSRKTKETSISVEVNIDGKGQYKIDTGIGFLDHMLEQLSKHSLIDLKVKAKGDTHIDLHHTTEDTGIAIGEALKKALKDFKGIKRYAHAMIPMDETLTRVAIDVSNRPYLIWKVKLKVERLGEMDTELFKEWFQAFSQSAGITLHMENIYGDNSHHIIESCYKALARSLRIALEIDPRNKKSIPSTKGSL
Catalytic Activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Sequence Mass (Da): 22173 Sequence Length: 196 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. Subcellular Location: Cytoplasm EC: 4.2.1.19
O94153
MSAGLPIRTATVTRNTNETQIVCSISLDHTPGVDQQIIDIQTGIGFLNHMLHAMAKHGNMSLTLHCKGDLEIDDHHTAEDCALALGEAFKLALGERRGIRRYGTGFAPLDEALSRAVLDISSRPYFCGDLPFTREKIGDLSTEMIPHVFESFATAAGVTLHVDCIRGVNNHHIAEASFKALALAIREAITRTGGNDVPSTKGVLL
Catalytic Activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O Sequence Mass (Da): 22127 Sequence Length: 205 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. EC: 4.2.1.19
Q3AD52
MNKPRYFKEAFAQLKPYEPHLVSYEIKLDANENPYLFPKSLLEEIFSKIGTRDFPLYPDPLAGRLRIRLSEKLGVLPENIVLGNGSDELILCLYLAFGGYGRIALSFSPSFVMYRHHAFVTQTEFFEVSYRDDFSLDLDETKKAIEKYQPHLVFLANPNNPTGTLVDIETIKKLLAYDHLLVVDEAYVEFSGVSAIDLLKKYQNLVILRTFSKARALAGLRLGYLVASVDVVKEIIKVKNPYNVNVFSQIAGEVVLANEEVFQGEIKEIVAERERLYNQLASLGLKPVKSHANFILVEFGEKAKKIHQELINHGILVRYLGGALANYLRITVGTPEENRQLLKKLGEIL
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39608 Sequence Length: 349 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q9A671
MPKPGIMDIHAYVGGKSKVEGIAHPVKLSSNENILGSSDKAKDAYRNAVDRLHIYPDGKANFLRAAVAERYKLEPERLTFGDGSDEIFALLCQVYLEPGDNIVQGEHGFAAYAIGARACQGEVRMAKEVNHRVDIDEVIKCVDERTRLVFIANPANPTGTWLTGEEIRALHAALPPSVVLVLDGAYAEFCSDPHFEDGLELARTAENVIVTRTFSKIHGLAALRVGWGYAPEHIIAPIERIRPPFNTSIPAQEAAVAALFDDDFQDRSRALVEQWRPWLAQQLGGLGLEVTPSAANFVLATFPTTPGKTAPEAEAFLASKGYLVRAVGNYNLPHAIRITIGLEEQNRAVVELLSQFMGR
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39262 Sequence Length: 359 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q47GP2
MSLADQALSYVRAISPYQPGKPITELAREMGIPVEKIVKLASNENPLGMSPKARKAVEAAISGIERYPDQFDLIAKVAERCGVSSNQIVLGNGSNDVLDLIARVFLAPGRSAVFAQHAFAVYPLATLSTGAELISTPAKNYGHDLNAMRAAIRPDTRIVWIANPNNPTGNFLPYPEVRAFLEVVPKDVVVVLDEAYNEYIPPAERVDTATWIKDFPNLVVCRTFSKIFGLAGLRVGYALASTEVADLMNRIRQPFNVNNLAIAAAVAALDDHLFVADSYELNRRGMEQIIAGLKRFGLEHIPSHGNFVTFRAGDAAVVNQKLLKQGVIVRPIGGYGLPEWLRVTIGTEPENARFLEALEKAL
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39502 Sequence Length: 362 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q5FRR4
MIPSHTAPSPFFPWSHRMNTAPECRTPPLSLARAEVRQLPVYNAGLSEDAVRAKYGIPRITKLGSNENPYGPSPAALEHWTEIASSLFRYPDASAEGLREELSRQTGIDTDRIVIGNGSEQIIRMICEAFLSPGDRLVTVLPSFGLHLIWPQMMGARAEAIPMTADARFDLPQLHQAVTSDPLKVLMFSNPSNPVGCLMTGDAMQSLIDACPADTLIVIDEAYWEYARSSPDYADSLTILKNQSRPWMVLRTFSKAYGLAGLRVGYALTSDPGLTAVMTRVRDPFNSNSAALEMARLSLLDQEHMHKTVGATLAEGKALKAALEERGYFVAQSFANFLFFNARESASALAERLLEQGVIVKPWKEKGYETWIRVSIARPEDSQAFLAALDRVRQPSHSSAA
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 44168 Sequence Length: 401 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q4QN73
MTITTLSRQNIQALTPYQSARKLGGNGTIWLNANEYPTSPEFQLSGKDLNRYPEPQPQRVVQAYANYAGVSTENVLVTRGGDEGIELIIHTFCEPKQDAILFCPPTYGMYAVSAETAGVLSKSVPLTDDFQLNLPEIKNHLNDVKVVFVCSPNNPTGNLLKQSDILDLLQITAGKAIVVVDEAYIEFCPEASVINLLKNYPHLAIIRTLSKAFALAGLRCGFVLANPELIDILSKVIAPYPIPVPSADLAEQALRPANIATVQALTQELLSNRQWLAKALLVLHQVEKVYESEANYLLIKCQNGQAVFKALWEQGIILRDQNKTLHLQNCIRITVGTRNECEKVVEAIKEVK
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 38891 Sequence Length: 352 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q5QZ49
MAEFNALELVNPGVKQLRPYQAGKPTSELQRELGLQHVVKLASNENPLGLSEKVKTALEAELTDLVRYPDANGYYLKSRLAELNEVGTQQITLGNGSNDVLEILARTFVSDKDEVIFSQHAFVVYPLVTQAIGAKPVAVPAVDYGHDLDGMAKAVTDKTKMIFIANPNNPTGTFLSTSALKSFLDKIPQHIIVVLDEAYYEYVPEDQRAPSVEWIKEYPNLVVSRTFSKAYGLAGLRAGYAVSHESVADVLNRIRQPFNMNSLSLKAAEVVLDDHAYLQKAVELNAQGMQLLTEFCEESGLNYIPSYGNFLTIEVGPGAEKLYDELLHEGVIVRPVGGYELPNHLRVSIGLPEENQAFIKAMKKLRG
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 40505 Sequence Length: 367 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q5ZW88
MSILNLVRADLLNSKNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQLAKRYQIYSDQIILTRGSDDGIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKIIMFCSPNNPTGNLVDLNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPYSIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLTTWLAHYGIAVRDFPSSSLLHDHLRITVGHDEQNQLLINTLSSFNADVAGLNYEKDFIY
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 41329 Sequence Length: 364 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q65S79
MTFLQQANTGVQALSPYQAGKPIEELERELGISNIIKLASNENPFGFPESAKKAIQNQLDNLTRYPDSNGFSLKAAIAEKFNLQPEQITLGNGSNDLIELIAHTFATEGDEIIFSQYAFIVYPLITKAINAKAREIPAKNWGHDLEAFLAAINEKTKLIFIANPNNPTGNFLTEAEIDSFLAKVPPHIVVALDEAYTEFTAKEERVNSLALLKKYPNLVVSRSLSKAYGLAGLRIGFAVSNPEIAGLFNRVRQPFNVNSLALAAAEAVLNDDDFVEKAAENNRRELKRYEEFCQKYGLQYIPSKGNFITIDFQQPAAPVYDALLHEGVIVRPIAGYGMPNHLRISIGLPEENQRLFDALIKILNLK
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 40606 Sequence Length: 366 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q82WM3
MTSPSPDQVIRQEILALSAYHVPPAKDMVKLDAMENPYRLPPFLCEEISRIAADTSINRYPDPHAAALKEVLSTTLSVPAGMEIMLGNGSDEIIQIIMLAAAKPEAKLLTIEPGFAMFKMIATFANMQYIGIPLKPDFSLDIDRMLAAIERHQPSVIFLAYPNNPSGNLFDTSALEKIIEISPGLVVIDEAYHPFAGKSFIGRLADYPNLLVMRTLSKLGLAGLRLGLLAGRPEWLSHLEKLRLPYNVNVITQLVATKIMQHYDVLQQQADAIRQTRTRLRTFLENLNGIEVFPSNANFILFRLDGASQIFRLLQQHGILVKNLDNSHPLLKNCLRVTVGTPEENDRFCNTLQDLIAGN
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39979 Sequence Length: 359 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q8YV89
MTNYFRSNVEAMASYVPGEQPPQGTQVIKLNSNENPYPPSPEALAAIKDIDGECLRRYPEPFGEEFRKAVSQLLGVPCNWVIVGNGSDEILSIVIRACAEPTRKVVYPVPTYVLYRTLTEMQAADILEIPYREYNILPVADLIAAHGSVTFIASPNSPSGHVVPSDDLRKLASELSGVLVIDEAYVDFAEESALNLVQDHENVILIRTLSKGYSLAGLRLGFGVGNPQLLNGLFKVKDSYNVDAIACKVATAAITDQAYKNACVAKVKASRTRLAKDLKQLGFCVWDSQANFLLTQPPQGNAEYLYQQLREKKILIRYFKQPGLEDKLRITVGTDEQNQILLQALRDLLESRD
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39106 Sequence Length: 353 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
A6GY79
MNNFNINNLVRENIKNMQAYASARDEFKDFTHNMVYLDANENPFSNGINRYPDPQQKKLKGFLAQQNKINENQMLLGNGSDEVLDLVFRAFCEPNVDNVITLPPTYGMYGVLANINAIENKEVLLSANFQPNINEILKNINENTKIIFLCSPNNPTGNSFDDQAVLTLLKNFNGLVVIDEAYIDFSKNGSWLHVISDYPNLLITQTLSKAYAMAGLRIGILYASAAIISILNKIKPPYNINNLSQESALKKLEQSTLNFHVKKIINERKKMVQSLISIPFIEKIYPSDANFILIKVEDANKRYNQLIEKGIVIRNRSNQPLCENCLRITIGTKEENEKLITVLKAL
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39232 Sequence Length: 346 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q2J8K9
MIFKAAGSGAEDRPWRPWDADGLPLRDSLRGLSPYGAPQLDVPVRLNTNENPHPPSVGLVDAIGKAAALAATEANRYPDRDAEALRADLAYYLTPDAGFGVHTSQVWAANGSNEILQQLLQAFGGPGRVALGFEPSYSMHRLIALATATEWVAGQRAEDFTLSPAVVTDAIARHRPALVFLCSPNNPTGTALPPEVVAAACEAVEATGSGMVVVDEAYAEFRRAGVPSTLTLLPRHPRLVVTRTMSKAFALAGARVGYLAAHPAVVDSLYLVRLPYHLSSFTQAVARTALAHADELLGTVEAVKAQRDRIVRELPALGLRLAPSDANFVFFGRFADQRAVWQSLLDAGVLVRDVGLTGWLRVTAGLPNEVDAFLGALGRTLTGSVIGADGVISLATA
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 42037 Sequence Length: 397 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
B0TY45
MQKIVQNQTTESLIRKDLQKFSAYSSARSLKVDGDIWLNANESPYNDEYLYNRYPEPQPRKLVEKLAKIYDVDASNILVTRGSDEGIDLLFRLYCEYQKDSAFAVEPTFGMYKIAAQLQGVDYKTLKLKEENNFEINITELLANIPDNCKLLFLCTPNNPTGKSIPLADIEQILSELAGNCVVVVDEAYIEFSNEKSVSSIINKYENLVVLRTLSKSFGMAGLRLGVVITNSDRIVWLRKILAPYPIPKTTESTILAMLDDENLANIASQIIEIKEQREHLYQALSQMKIVDKLWSSDANFILVRFRESIFNKLIDNKIVVRSMAHFFNDEKVLRISIGTVSENKRLIEVLQKLSSEYETK
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 41272 Sequence Length: 361 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q39YP6
MIPLRQNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDGAALRIYPSASSQKLREVAGELYGFDPSWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARVRTFGLTGDFRIAGFPERYEGKVFFLTTPNAPLGPSFPLEYIDELARRCAGMLVLDETYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDHYNLDRLAQAACVAALRDQAYLSECCRRIRETREWFTTELRSIGYDVIPSQGNYLFATPPDRDGKRVYDGLYARKVLVRHFSDPLLAHGMRISIGTREEMEQTLAALKEIG
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39135 Sequence Length: 350 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q7NL03
MMQPYLRPDLDRLQAYHAPHFPEADKLDANELPHDLPEWLKNKLAFLLEQGVRTNRYPEGDPLALKAAIAEYCGVTSEMVCVGNGSDELIRSLITATCLGGRGTVASAEPTFSMYRILAETLAVPYIGVARTANYGVDADVLEAAVGANGVRVLFLANPNSPTGNLLSDEIIERLGSLPVLVVLDEAYYEFSRFSAVPLLWERPNLVILRTFSKAFRLANFRVGYALANPEIAAVLEKVRLPYNLPGLSQLAAFAALEHRDVLLAAIPEILAERRRIERFLADFEQLELFPSDANFLFVRPRIADPEAVRVALAGRGSLVRGAAGGLRVTVGTPEQNDRLIANVAALFTPEMR
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 38753 Sequence Length: 353 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
Q0BVW4
MSNPRPNPGIEAIHPYIGGESKLPGVEQVIKLSSNEGAFGPPPAAQQAYLKAVSSLHRYPDGGSHALREAIGRYFGLDPARIVCGVGSDEMIAHLCMAYSNPDSELIMSVHGFSVYEMYGHYAGAKVVKVPEQALTTDVDALLDAITPRTKVVCIANPNNPTGTMLPTAEIARLRASLPSDVLLVLDAAYAEYVDDPDYDPGVKLVDAGDNTVMTRTFSKIFGLGGLRLGWAYAPPAIVDVLNRVRGPFTVNAAVQEAAIGALEEPGWVERSRAHNSAARAKLATALFDIGIPTLPSVTNFLLADFGSEARAGAADRWLRTRGLIVRRVASYGLPAYLRITIGTNEECDLVAEALRAFMAQAPADSDAAS
Catalytic Activity: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate Sequence Mass (Da): 39403 Sequence Length: 370 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. EC: 2.6.1.9
P38635
MHSHHSHSGDYSAHGTDPLDSVVDQVVNLNFHTYCLTEHIPRIEAKFIYPEEQSLGKNPEEVITKLETSFKNFMSHAQEIKTRYADRPDVRTKFIIGMEIESCDMAHIEYAKRLMKENNDILKFCVGSVHHVNGIPIDFDQQQWYNSLHSFNDNLKHFLLSYFQSQYEMLINIKPLVVGHFDLYKLFLPNDMLVNQKSGNCNEETGVPVASLDVISEWPEIYDAVVRNLQFIDSYGGAIEINTSALRKRLEEPYPSKTLCNLVKKHCGSRFVLSDDAHGVAQVGVCYDKVKKYIVDVLQLEYICYLEESQSPENLLTVKRLPISQFVNDPFWANI
Catalytic Activity: H2O + L-histidinol phosphate = L-histidinol + phosphate Sequence Mass (Da): 38582 Sequence Length: 335 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. EC: 3.1.3.15
I3J7Q8
MKIDTSLNMPQLPEALSQAGLQFSVATEEDFDEIMAMSQDIYGGLDYLPTRYTSWLQDTNRTVILARKHGKVIALESVCVIDDGETMLVEGLRVAPQERGKGVAGVLLRFCAELVKSRYPEVKVCRLTRDDQLGPKDFEKYRIITKQGILLMRFRAEDLKLHLSEFGLEGDNESTLSTFCSSPPPVRLDHTAIQQLYLNSDLLHGVLPNATIIQDWQPFKLLPSNMAILLKKEIDWMVDDMSNPTVASLCTFPFRVPIGDDWYYLNIDMFGKDLALARQQFLYHLQRHTATLKGHVMCQMFLDPPLWKAMAEFCHNTLSVELVKEYTEQCVVECDLI
Function: Enzyme responsible for the N-acetyl-histidine (NAH) synthesis, which is a major constituent of brain and lens of ectothermic vertebrates. Catalytic Activity: acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-histidine Sequence Mass (Da): 38413 Sequence Length: 337 EC: 2.3.1.33
Q0P4Y1
MKIEAVPGAPQDGEFEFVLAAEKEFEEIISISHGIYGGLDYLPSRYHSWINEKDRMVVLAKKDGTVIGLLSVFVVDGGETALLEGLRVAPWERGRGVAGVLQRFCIKLVKHRYPSVKVMRLTRDDKLSAKELTKYRVIAKQGILLLSFNAPDLASRLSSIPLPPAASRPPPPIELTPEDVRDVFLERGGLLKDLLPNQTIIQDWQPFQALPGNQDLLRRKTLCWMVDDLIQPQVATLCTAPFPVPAGPLCFYLNIDVFGSELQSVQEQLLSHLHAHVPKLPADVRCQLFLPPNLWRPMADFCTLVLGLHLEKGYTEQYLLEADI
Function: Enzyme responsible for the N-acetyl-histidine (NAH) synthesis, which is a major constituent of brain and lens of ectothermic vertebrates. Catalytic Activity: acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-histidine Sequence Mass (Da): 36276 Sequence Length: 324 EC: 2.3.1.33
Q46125
MKKFLTAFLVAFTGLFLVACQNTKTENNASNEANTTLTLKVGTAPNYKPFNFKQDSKLTGFDTDLIEEIAKKNGIEIVWVETNFDGLIPALKSGKIDMIASAMSATDERRQSVDFTKPYYMSKNLYLKLKNNDSLQTKNDLEGKKIGVQLGTLQENTAKAIKNAQVQSNKDLNIAVLALKNNKIDAIVADQDTAKGFLAENPELVSFYQETDGGEGFSFAFDKNKQKDIIEIFNKGIDEAKTDGFYDTLIKKYELE
Function: Involved in histidine transport. Location Topology: Lipid-anchor Sequence Mass (Da): 28531 Sequence Length: 256 Subcellular Location: Cell membrane
Q06758
MNMKKWIAAALACSALALSACGGQGKDAAAPAANPGKVYRVASNAEFAPFESLDSKGNVEGFDVDLMNAMAKAGNFKIEFKHQPWDSLFPALNNGDADIVMSGVTITDDRKQSMDFSDPYFEITQVVLVPKGKKVSSSDDLKKMNKVGVVTGHTGDFSVSKLLGNDNPKIARFENVPLIIKELENGGLDSVVSDSAVIANYVKNNPAKGMDFVTLPDFTTEHYGIAVRKGDEATVKMLNDALEKVRESGEYDKIYAKYFAKEGGQAAK
Function: Involved in histidine transport. Location Topology: Lipid-anchor Sequence Mass (Da): 28859 Sequence Length: 268 Subcellular Location: Cell membrane
P0AEU5
MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSSTH
Function: Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26870 Sequence Length: 238 Subcellular Location: Cell inner membrane
P56160
MTPDLQLALELAEKAGKLTLDYFGRRSLQVFSKRDDTPVTEADRNAEELIRQGISAKFPDDGLFGEEFDEHPSGNGRRWIIDPIDGTRSFIHGVPLYGVMIALEVEGAMQLGVINFPALGELYQAERGSGAFMNGSPVQVSAIAENSASTVVFTEKEYLLDPPSNHPVDQLRIDAGLVRGWGDCYGHMLVASGRAEVAVDKIMSPWDCAAVIPIVEEAGGCCFDYRGRQSIIDGEGLVSANNAMGRNLIAAIGNGERDR
Function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine. Catalytic Activity: H2O + L-histidinol phosphate = L-histidinol + phosphate Sequence Mass (Da): 28059 Sequence Length: 259 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. EC: 3.1.3.15
Q8NS80
MSKYADDLALALELAELADSITLDRFEASDLEVSSKPDMTPVSDADLATEEALREKIATARPADSILGEEFGGDVEFSGRQWIIDPIDGTKNYVRGVPVWATLIALLDNGKPVAGVISAPALARRWWASEGAGAWRTFNGSSPRKLSVSQVSKLDDASLSFSSLSGWAERDLRDQFVSLTDTTWRLRGYGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVTEAGGKFTSLAGVDGPHGGDAVATNGILHDETLDRLK
Function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine. Catalytic Activity: H2O + L-histidinol phosphate = L-histidinol + phosphate Sequence Mass (Da): 27893 Sequence Length: 260 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. EC: 3.1.3.15
P95189
MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLSGWARPGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGGSAVATNGLLHDEVLTRLNAG
Function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine. Catalytic Activity: H2O + L-histidinol phosphate = L-histidinol + phosphate Sequence Mass (Da): 27693 Sequence Length: 260 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. EC: 3.1.3.15
Q9K4B1
MPDYLDDLRLAHVLADAADAATMDRFKALDLKVETKPDMTPVSEADKAAEELIRGHLSRARPRDSVHGEEFGVAGTGPRRWVIDPIDGTKNYVRGVPVWATLIALMEAKEGGYQPVVGLVSAPALGRRWWAVEDHGAFTGRSLTSAHRLHVSQVSTLSDASFAYSSLSGWEEQGRLDGFLDLTREVWRTRAYGDFWPYMMVAEGSVDLCAEPELSLWDMAANAIIVTEAGGTFTGLDGRPGPHSGNAAASNGRLHDELLGYLNQRY
Function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine. Catalytic Activity: H2O + L-histidinol phosphate = L-histidinol + phosphate Sequence Mass (Da): 29084 Sequence Length: 266 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. EC: 3.1.3.15
P73058
MTRILKLSHLTPQQLNQLKRRSEQNIDQALAIAKEVIEQVKMEGDAGVLHYSRQFDFAGATAENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPPMHLAEIEPGVFAGEKITPLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPPDKEGKVEPVSLVTARMAGVDEVYKLGGVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLSGIVDVGLPAGPSESIVLADETTDPKLAALDLLIEAEHGSDSAALLVTHSASLAEKALGYLGEYLEKLPPWRKKFCEDGLGSYGGILLTDSLQASLDFINDYAPEHLQVLTADPLKLVGKIDNAGEILLGNYTPSSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLADYEDFPAHALAIRERENLL
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. Catalytic Activity: H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH Sequence Mass (Da): 46534 Sequence Length: 434 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. EC: 1.1.1.23
Q5JFR5
MKGLEEYVREILEDIRRRGLEALREYSERFDNYSGPFRVSEGEFEEAEELVPEEDKRVIEETMERLWEYHARQFRDVELYIKRGSLYGLIYRPIGRIGIYVPGGKPLPSTLMMVGIPARIAGVREIAVTTPPKDGKVNPYVLYVAKLLGIEEVYKLGGVGAIAAMAYGVGMRRVDKIFGPGNRFVNEAKRQVFGIVGIDSLAGPSEIAVIADESADKDYVLADLLSQLEHGKDSKAWLLTTSRELADYCSREGIEVLLCRNLEECAEKANEIAPEHLEIITENPEELVDLIENAGAIYLGPYTPVPAADYFLGVNHVLPTGGAARFSGVLTVMDFMKPITLARVSREEFLAYRRLGMRLAEIEGMEAHRRSLEVRR
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. Catalytic Activity: H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH Sequence Mass (Da): 42216 Sequence Length: 376 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. EC: 1.1.1.23
Q9X0D1
MILMNNPGDKEVLRLLKQRMESVSQVEETVKEIIRRVKEEGDRALEEFLKRFEKHPVGIENLRVTEKEISEAQVEEEFVETIKIVIEDLKEFHRRQEERSFFFTTKGGSFLGEMVVPLESVGIYVPGGKVPYFSTLLMCAVPAIVAGVERIAVTTPPNENGGISPYILKTCEILGLKEIYRMGGAHAVAALTYGTETVKPVDKIVGPGGVFVTLAKKHVYGDVGIDSIAGPSEIAIVTDGSADLDLIAADFLSQAEHDENAMSVVITTSKEVFEKLPQVIERHLEALPEERRKTARISTENFGTIILTDSLKRAFEISNLIAPEHLEVLVENPFEPLGHIKNAGSVFLGKYTCESVGDYGAGPNHVLPTFRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMARWEGFEAHARAIDVRREKL
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. Catalytic Activity: H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH Sequence Mass (Da): 47749 Sequence Length: 428 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. EC: 1.1.1.23
Q8P9P2
MNTLDWTQLTADARTQALTRPVQTVATQTREAVATLIADVRARGDVALREITARFDGVTLESFAVSDAEFAAADAAIAPELRQAMQDAVARIDTFHRAGMSEGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCREVVLCTPPRKDGSVDPAVLVAAQLTGVRRVFKLGGAQAIAAMAYGTDSIPSCDKLFGPGNSFVTEAKQQVAQSGAAAIDMPAGPSEVLVIADAGAQPAFVAADLLSQAEHGPDSQVLLLSDSDALITAVQEQLDLQLAQLSRADIARQALAQSRLIKVATLQDAFEISNRYAPEHLILALREPRAWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMVSVQAASKAGIDGIGACAVILARAEGLDAHANAVALRMGVAA
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. Catalytic Activity: H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH Sequence Mass (Da): 44665 Sequence Length: 431 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. EC: 1.1.1.23
Q4FTX3
MLPDGVADVLFEDAHKQEVLRHQLTQQLITHGYQLVSPPMIEFTESLLSGASEDLKRQTFKIIDQLTGRLMGIRADITPQILRIDAHHGGDGIARYCYAGDVIHTLPSGLFGSRTPLQLGAEIFGCESIAADIELIDVLFSMINSLDMSAVLHVDLGHVTIFKRLAELAALSASDTEQLMQLYANKNLPELKQVCQVLPMGSDFYTLARFGHDIANLLGRLSENAQQDTKIVTAIDELQRLKAHLQVQWQCAVSIDVTELSGYHYHTGIVFNGYINSETQPLVRGGRFDGMKSNQLATNQPRQATGFSMDVSRLLAHTQLDAPFIVLIDYDAFNNLDSAQRQLLLQQVASLRQQGYRVTMPLTAEDMPVGLTHRLSLADNQWRLHAV
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Sequence Mass (Da): 43028 Sequence Length: 387 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. Subcellular Location: Cytoplasm
Q7VZF5
MIVVTGAAGFIGSNLVRGLNRRGIQDIIAVDDLTDGDKFRNLVDCSIADYLDKDEFRERVRGGNLPALRAVLHQGACSDTTERNGRYMLDNNYRVTLELFEYCQAERVPFLYASSAAVYGGSSVYVEDPANEHPLNVYGYSKLLFDQVLRTRMDSLTAQVVGLRYFNVYGPHEQHKGRMASVAFHNMNQFLAEGHVRLFAGWDGYEDGGQSRDFISVEDVVAVNLHFLDNPDQSGVFNCGTGRAQPFNDVAAAVVNTLRAERGEAALPLAELVKKGLLRYIPFPDDLKGRYQSYTQADVSRLRATGFSAPMRDVQTGVSEYVRYWRALK
Cofactor: Binds 1 NADP(+) per subunit. Function: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. Catalytic Activity: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose Sequence Mass (Da): 36760 Sequence Length: 329 Domain: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain. Pathway: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. EC: 5.1.3.20
C0QZ84
MIIVTGGAGFIGSNIVKGLNNLGIDDILVVDNLKNASKHKNLNRIKFRDYIDKEDFNLDYLTSFVNNNKVEAIFHQGACSDTMETDGKYMMKNNYEYTKNILHICLDKKIRLFYASSASVYGNGENGFEEDEKNEYPLNVYAFSKYHFDRYLNKLFKENKVNSQVVGLRYFNVYGPQENHKGRMASVAFHLFNQIKAGERMKIFEGSENFLRDFIHIDDVVSVNNFFFENPNKSGIFNCGTGNAESFVEIAKALKEVYKSASIEYIAFPDALRGKYQKYTQADLKKLRAAGYDKPFMNVNTGVKKYAEVLEKSGGYLM
Cofactor: Binds 1 NADP(+) per subunit. Function: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. Catalytic Activity: ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose Sequence Mass (Da): 36366 Sequence Length: 318 Domain: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain. Pathway: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. EC: 5.1.3.20
A8I5B0
MLAETQLAPIAVIGDVMVDRYITGSVSRISPEAPVPVLVHGAERIVPGGAANVAANAAALGAPVLLVGLVGEDEAASQLADALATYPGISLAHMVVDAKRPTITKTRVMSGRQQIVRIDAEVTRACDAAEEAALIGAAEAAIAKAGVVVLSDYAKGVLSDAVIAAAMAAAKARNVPVIVDPKRRTFEAYRGATLVTPNRRELAEATGLPDETDADAARAAEAAGRQFGGDVLVTRAEKGMTLWRQDGRVLHVPAEAREVFDVSGAGDTALAALAVSLAGGQSLEASVGIANAAAALAVAKLGTAVVTRAELRAALERTAAQIAPPGALVSREDACAVVAAWKAQGLRVVFTNGCFDLVHPGHVSLLEQSAAQGDRLVVALNTDASVRRLKGPSRPLQDEQARARVMGAMRCVDLVVLFDEETPLETIKALLPDVLVKGADYAPHEVVGADVVTANGGELVLVDLVAGKSTSSLVAKART
Function: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Catalytic Activity: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) Sequence Mass (Da): 49173 Sequence Length: 479 Pathway: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Q89HR3
MPTPILDFDALAQTISGRTVLCIGDIMLDEFVYGEVSRISPEAPTPVIVAQRSEIHIGGAGNVARNVASLGARCIFVGLVGEDDAGKRLAAALADQAAIESVLVCDPSRPTTRKVRFVSEHFSTHMLRADWEQAQPASDEVEAKLIEAILPQIARADIVLLSDYAKGVLTARVIRHTIDAARKLGKPVIVDPKSLNWAIYRGATLLTPNRKEFAEATRSRADTPQSIVDASEDVMRLADCEAILVTQGEHGMTLVPRNGAAVHVPAVPVKVRDVSGAGDTVAAALAVSLAAGADWDTALRVANAAASVAVSKLGTAIVSTAELRRKILPHAYLAAEEKIVLEPAALDAQLAEWRTQGLRVGFTNGCFDILHPGHVKVLTAARGACDRLVVGLNSDASVRRLKGADRPVQDERARAEVLAALEAVDLVVIFEEDTPIDLITRIKPAALVKGGDYTREQVVGHEVVEAAGGVVVLVDILQGFSTTALVHRARGGAK
Function: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Catalytic Activity: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) Sequence Mass (Da): 52389 Sequence Length: 494 Pathway: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Q6TG09
MLEFLSQQKPKILIIGDFMVDNYTWCDCSRISPEAPVLIAKTLKEDKRLGGAANVYANLKSLGADVFALGVVGDDESGKFLQENLKGEFLIQKGRKTPFKNRIMAHNQQVLRLDEEDISEILLENELIALFDEKIKDFKAVVLSDYAKGVLTPKVCKAVIEKAKVLNIPVLVDPKGSDFNKYSGATLLTPNKKEALEALKFENLEGENLEKGIKKLKEDFSLRYSIITLSEAGIALFDEGLKIAPAKALEVYDVTGAGDSVIAVLAFCLANEIEIFKACELANEAAAVVVSKIGSVSVSFDEIKSFKRVDFEKKIKSKEELLVLLKQNNKKIVFTNGCFDIVHFGHIKYLDKAKRLGDVLIVGLNSDASVKRLKGESRPVNSEFQRACMLAAFYFVDFVVIFDEDTPLELISFLKPDILVKGADYKDKLVVGADIVSRVELIDFEEGFSTSKIIEKIKDKK
Function: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Catalytic Activity: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) Sequence Mass (Da): 51238 Sequence Length: 461 Pathway: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Q9A2C5
MDDALAHLPRAFAGKTVLVLGDVMLDRFIYGAVDRISPEAPVPVIAVEKETAMLGGAGNVARNVAALGAKAVLIGLVGRDDAGAALRGMIDAEAGLEAELVVDPARRTTEKVRYISGSHQMLRVDREDRSPGDGAALLAAFETRLASADVVVLSDYAKGVLTPAVVRGAIDAAKAAGKPVIVDPKSRDFARYDGATLIKPNRKEAAEATGIVETSDAASEDAGAAILAMAPGLQAALITRGGAGMTLAVRNQPPIHLPATAIEVFDVSGAGDTVAATLALAVAAGASLAQAAQLANLAGGLVVAKLGTDVVTAAELTACASSAQGEPGEIKIADREQAQRIVEGWRARGLKVGFTNGCFDLLHPGHVSLLSQAKAACDRLIVGLNTDASVSKLKGPTRPVQKEQGRATVLASLSSVDLVVLFDEDTPLELIKAFRPDVLVKGADYTVETVVGSDVVLGYGGKVVLAELKQGQSTTNLIARMNS
Function: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Catalytic Activity: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) Sequence Mass (Da): 49622 Sequence Length: 483 Pathway: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Q6H7M3
MEQNGENHLKDPLLQADGGGSGASPAGASPRKERKTRKVMFNVRGISCASCAVSIETVVAGLKGVESVSVSPLQGQAVVQYRPEEADARTIKEAIEGLNFEVDELQEQEIAVCRLQIKGMACTSCSESVERALQMVPGVKKAAVGLALEEAKVHFDPNITSRDLIIEAIEDAGFGADLISSGDDVNKVHLKLEGVSSPEDIKLIQSRLESVEGVNNVECDTAGQTIIVAYDPDVTGPRLLIQCIQDAAQPPKYFNASLYSPPKQREAERHHEIRNYRNQFLWSCLFSVPVFMFSMVLPMISPFGDWLFYKVCNNMTIGMLLRWLLCSPVQFIIGWRFYVGAYHALKRGYSNMDVLVALGTNAAYFYSVYIVLKALTSESFEGQDFFETSAMLISFILLGKYLEVVAKGKTSDALSKLTELAPETACLLTLDKDGNAISETEISTQLLQRNDVIKIVPGEKVPVDGVVIKGQSHVNESMITGEARPIAKKPGDKVIGGTVNDNGCIIVKVTHVGSETALSQIVQLVEAAQLARAPVQKLADRISRFFVPTVVVAAFLTWLGWFVAGQFDIYPREWIPKAMDSFELALQFGISVLVVACPCALGLATPTAVMVATGKGASQGVLIKGGNALEKAHKVKAIIFDKTGTLTVGKPSVVQTKVFSKIPLLELCDLAAGAEANSEHPLSKAIVEYTKKLREQYGSHSDHIMESKDFEVHPGAGVSANVEGKLVLVGNKRLMQEFEVPISSEVEGHMSETEELARTCVLVAIDRTICGALSVSDPLKPEAGRAISYLSSMGISSIMVTGDNWATAKSIAKEVGIGTVFAEIDPVGKAEKIKDLQMKGLTVAMVGDGINDSPALAAADVGLAIGAGTDVAIEAADIVLMRSSLEDVITAIDLSRKTLSRIRLNYVWALGYNVLGMPVAAGVLFPFTGIRLPPWLAGACMAASSVSVVCSSLLLQLYKKPLHVEEVAAGPKNDPDLV
Function: Copper (Cu) transporter that mediates Cu transport in root vacuoles. Involved in Cu detoxification by sequestrating Cu into root vacuoles and limiting translocation of Cu from the roots to the shoots, and accumulation in grains. Catalytic Activity: ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 105130 Sequence Length: 978 Subcellular Location: Vacuole membrane EC: 7.2.2.8
Q9SH30
MATKLLSLTCIRKERFSERYPLVRKHLTRSRDGGGGSSSETAAFEIDDPISRAVFQVLGMTCSACAGSVEKAIKRLPGIHDAVIDALNNRAQILFYPNSVDVETIRETIEDAGFEASLIENEANERSRQVCRIRINGMTCTSCSSTIERVLQSVNGVQRAHVALAIEEAEIHYDPRLSSYDRLLEEIENAGFEAVLISTGEDVSKIDLKIDGELTDESMKVIERSLEALPGVQSVEISHGTDKISVLYKPDVTGPRNFIQVIESTVFGHSGHIKATIFSEGGVGRESQKQGEIKQYYKSFLWSLVFTVPVFLTAMVFMYIPGIKDLLMFKVINMLTVGEIIRCVLATPVQFVIGWRFYTGSYKALRRGSANMDVLIALGTNAAYFYSLYTVLRAATSPDFKGVDFFETSAMLISFIILGKYLEVMAKGKTSQAIAKLMNLAPDTAILLSLDKEGNVTGEEEIDGRLIQKNDVIKIVPGAKVASDGYVIWGQSHVNESMITGEARPVAKRKGDTVIGGTLNENGVLHVKVTRVGSESALAQIVRLVESAQLAKAPVQKLADRISKFFVPLVIFLSFSTWLAWFLAGKLHWYPESWIPSSMDSFELALQFGISVMVIACPCALGLATPTAVMVGTGVGASQGVLIKGGQALERAHKVNCIVFDKTGTLTMGKPVVVKTKLLKNMVLREFYELVAATEVNSEHPLAKAIVEYAKKFRDDEENPAWPEACDFVSITGKGVKATVKGREIMVGNKNLMNDHKVIIPDDAEELLADSEDMAQTGILVSINSELIGVLSVSDPLKPSAREAISILKSMNIKSIMVTGDNWGTANSIAREVGIDSVIAEAKPEQKAEKVKELQAAGHVVAMVGDGINDSPALVAADVGMAIGAGTDIAIEAADIVLMKSNLEDVITAIDLSRKTFSRIRLNYVWALGYNLMGIPIAAGVLFPGTRFRLPPWIAGAAMAASSVSVVCCSLLLKNYKRPKKLDHLEIREIQVERV
Function: Involved in copper import into the cell. May play a role in copper detoxification in roots. Catalytic Activity: ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 108336 Sequence Length: 995 Subcellular Location: Membrane EC: 7.2.2.8
A3AWA4
MAASTRALFLSCFHGSGGGGGTSEVSRRLVLRPRYPSMPRRPRSAAVAGEGGEGGGGGGDGDLEAAAVGAEEEEKVAVFEVSGMTCAACAGSVEKAVKRLQGIHDAAVDVLGGRAQVVFYPAFVSEEKIRETIQDVGFEAKLIDEEVKEKNILVCRLHIKGMTCTSCASTVESILQVVPGVQRASVALATEEAEIRYDRRIVTASQLTHAVEETGFEAILITTGDDQSRIDLKVDGTLNERSIMIVKSSVQALPGVEDIKVDPELHKITISYKPDQTGPRDLIEVIESAASGDLTVSIYPEADGRQQHRHGEIKRYRQSFLWSLVFTIPVFLTSMVFMYIPGLKDGLEKKVINMMSIGELLRWILSTPVQFVIGRRFYTGAYKALSHGSSNMDVLIALGTNTAYFYSVYSILRAASSHNYMATDFFETSSMLISFILLGKYLEILAKGKTSEAIAKLMDLAPETATMLIYDHEGNVVGEKEIDSRLIQKNDVIKVVPGGKVASDGFVIWGQSHVNESMITGESRPVAKRKGDTVIGGTVNENGVLHVRATFVGSESALAQIVRLVESAQMAKAPVQKFADQISRVFVPLVIILSLLTWLAWFLAGRLHGYPNSWIPSSMDSFQLALQFGISVMVIACPCALGLATPTAVMVATGVGASQGVLIKGGQALESAQKVDCIVFDKTGTLTIGKPVVVNTRLLKNMVLREFYAYVAAAEVNSEHPLGKAVVEHAKKFHSEESHVWTEARDFISVTGHGVKAKISGRAVMVGNKSFMLTSGIDIPVEALEILTEEEEKAQTAIIVAMDQEVVGIISVSDPIKPNAREVISYLKSMKVESIMVTGDNWGTANAISKEVGIENTVAEAKPEQKAEKVKELQSAGRTVAMVGDGINDSPALVSADVGLAIGAGTDVAIEAADIVLMKSNLEDVITAIDLSRKTFFRIRMNYVWALGYNIIGIPIAAGVLFPSTRFRLPPWVAGAAMAASSVSVVCWSLLLRYYKSPKLGR
Function: Copper (Cu) transporter that plays an essential role in promoting translocation of Cu from roots to shoots. Involved in loading Cu to the xylem of the roots and other organs, including panicles. Catalytic Activity: ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 107987 Sequence Length: 1002 Subcellular Location: Cell membrane EC: 7.2.2.8
Q9SZC9
MESTLSAFSTVKATAMARSSGGPSLPLLTISKALNRHFTGARHLHPLLLARCSPSVRRLGGFHGSRFTSSNSALRSLGAAVLPVIRHRLECLSSSSPSFRSISSGGGSGFGGYNGGSGGGGGGGSESGDSKSKLGANASDGVSVPSSDIIILDVGGMTCGGCSASVKKILESQPQVASASVNLTTETAIVWPVPEAKSVPDWQKSLGETLANHLTNCGFQSTPRDLVTENFFKVFETKTKDKQARLKESGRELAVSWALCAVCLVGHLTHFLGVNAPWIHAIHSTGFHVSLCLITLLGPGRKLVLDGIKSLLKGSPNMNTLVGLGALSSFSVSSLAAMIPKLGWKTFFEEPVMLIAFVLLGRNLEQRAKIKATSDMTGLLSVLPSKARLLLDGDLQNSTVEVPCNSLSVGDLVVILPGDRVPADGVVKSGRSTIDESSFTGEPLPVTKESGSQVAAGSINLNGTLTVEVHRSGGETAVGDIIRLVEEAQSREAPVQQLVDKVAGRFTYGVMALSAATFTFWNLFGAHVLPSALHNGSPMSLALQLSCSVLVVACPCALGLATPTAMLVGTSLGARRGLLLRGGDILEKFSLVDTVVFDKTGTLTKGHPVVTEVIIPENPRHNLNDTWSEVEVLMLAAAVESNTTHPVGKAIVKAARARNCQTMKAEDGTFTEEPGSGAVAIVNNKRVTVGTLEWVKRHGATGNSLLALEEHEINNQSVVYIGVDNTLAAVIRFEDKVREDAAQVVENLTRQGIDVYMLSGDKRNAANYVASVVGINHERVIAGVKPAEKKNFINELQKNKKIVAMVGDGINDAAALASSNVGVAMGGGAGAASEVSPVVLMGNRLTQLLDAMELSRQTMKTVKQNLWWAFGYNIVGIPIAAGVLLPLTGTMLTPSMAGALMGVSSLGVMTNSLLLRYRFFSNRNDKNVKPEPKEGTKQPHENTRWKQSS
Function: Mediates copper transfer across the plastid envelope. Required for the delivery of copper into the plastid stroma, which is essential for the function of copper proteins. Seems to be selective for monovalent copper Cu(+) transport. Also plays a role in glucose signaling-mediated cell proliferation of root meristem in non-green tissues. Catalytic Activity: ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 99997 Sequence Length: 949 Subcellular Location: Plastid EC: 7.2.2.8
Q9S7J8
MAPSRRDLQLTPVTGGSSSQISDMEEVGLLDSYHNEANADDILTKIEEGRDVSGLRKIQVGVTGMTCAACSNSVEAALMNVNGVFKASVALLQNRADVVFDPNLVKEEDIKEAIEDAGFEAEILAEEQTQATLVGQFTIGGMTCAACVNSVEGILRDLPGVKRAVVALSTSLGEVEYDPNVINKDDIVNAIEDAGFEGSLVQSNQQDKLVLRVDGILNELDAQVLEGILTRLNGVRQFRLDRISGELEVVFDPEVVSSRSLVDGIEEDGFGKFKLRVMSPYERLSSKDTGEASNMFRRFISSLVLSIPLFFIQVICPHIALFDALLVWRCGPFMMGDWLKWALVSVIQFVIGKRFYVAAWRALRNGSTNMDVLVALGTSASYFYSVGALLYGAVTGFWSPTYFDASAMLITFVLLGKYLESLAKGKTSDAMKKLVQLTPATAILLTEGKGGKLVGEREIDALLIQPGDTLKVHPGAKIPADGVVVWGSSYVNESMVTGESVPVSKEVDSPVIGGTINMHGALHMKATKVGSDAVLSQIISLVETAQMSKAPIQKFADYVASIFVPVVITLALFTLVGWSIGGAVGAYPDEWLPENGTHFVFSLMFSISVVVIACPCALGLATPTAVMVATGVGATNGVLIKGGDALEKAHKVKYVIFDKTGTLTQGKATVTTTKVFSEMDRGEFLTLVASAEASSEHPLAKAIVAYARHFHFFDESTEDGETNNKDLQNSGWLLDTSDFSALPGKGIQCLVNEKMILVGNRKLMSENAINIPDHVEKFVEDLEESGKTGVIVAYNGKLVGVMGIADPLKREAALVVEGLLRMGVRPIMVTGDNWRTARAVAKEVGIEDVRAEVMPAGKADVIRSLQKDGSTVAMVGDGINDSPALAAADVGMAIGAGTDVAIEAADYVLMRNNLEDVITAIDLSRKTLTRIRLNYVFAMAYNVVSIPIAAGVFFPVLRVQLPPWAAGACMALSSVSVVCSSLLLRRYKKPRLTTVLKITTE
Function: Involved in copper import into the cell. Essential for ethylene signaling, which requires copper. Acts by delivering copper to create functional hormone receptors. Catalytic Activity: ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 107395 Sequence Length: 1001 Subcellular Location: Membrane EC: 7.2.2.8
B9DFX7
MASNLLRFPLPPPSSLHIRPSKFLVNRCFPRLRRSRIRRHCSRPFFLVSNSVEISTQSFESTESSIESVKSITSDTPILLDVSGMMCGGCVARVKSVLMSDDRVASAVVNMLTETAAVKFKPEVEVTADTAESLAKRLTESGFEAKRRVSGMGVAENVKKWKEMVSKKEDLLVKSRNRVAFAWTLVALCCGSHTSHILHSLGIHIAHGGIWDLLHNSYVKGGLAVGALLGPGRELLFDGIKAFGKRSPNMNSLVGLGSMAAFSISLISLVNPELEWDASFFDEPVMLLGFVLLGRSLEERAKLQASTDMNELLSLISTQSRLVITSSDNNTPVDSVLSSDSICINVSVDDIRVGDSLLVLPGETFPVDGSVLAGRSVVDESMLTGESLPVFKEEGCSVSAGTINWDGPLRIKASSTGSNSTISKIVRMVEDAQGNAAPVQRLADAIAGPFVYTIMSLSAMTFAFWYYVGSHIFPDVLLNDIAGPDGDALALSLKLAVDVLVVSCPCALGLATPTAILIGTSLGAKRGYLIRGGDVLERLASIDCVALDKTGTLTEGRPVVSGVASLGYEEQEVLKMAAAVEKTATHPIAKAIVNEAESLNLKTPETRGQLTEPGFGTLAEIDGRFVAVGSLEWVSDRFLKKNDSSDMVKLESLLDHKLSNTSSTSRYSKTVVYVGREGEGIIGAIAISDCLRQDAEFTVARLQEKGIKTVLLSGDREGAVATVAKNVGIKSESTNYSLSPEKKFEFISNLQSSGHRVAMVGDGINDAPSLAQADVGIALKIEAQENAASNAASVILVRNKLSHVVDALSLAQATMSKVYQNLAWAIAYNVISIPIAAGVLLPQYDFAMTPSLSGGLMALSSIFVVSNSLLLQLHKSETSKNSL
Function: Mediates copper transfer across the chloroplast thylakoid membrane. Required for copper delivery into the thylakoids lumen, which is essential for the function of copper proteins. Catalytic Activity: ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 94260 Sequence Length: 883 Subcellular Location: Plastid EC: 7.2.2.9
O52791
MQNFEIDYVEMYVENLEVAAFSWVDKYAFAVAGTSRSADHRSIALRQGQVTLVLTEPTSDRHPAAAYLQTHGDGVADIAMATSDVAAAYEAAVRAGAEAVRAPGQHSEAAVTTATIGGFGDVVHTLIQRDGTSAELPPGFTGSMDVTNHGKGDVDLLGIDHFAICLNAGDLGPTVEYYERALGFRQIFDEHIVVGAQAMNSTVVQSASGAVTLTLIEPDRNADPGQIDEFLKDHQGAGVQHIAFNSNDAVRAVKALSERGVEFLKTPGAYYDLLGERITLQTHSLDDLRATNVLADEDHGGQLFQIFTASTHPRHTIFFEVIERQGAGTFGSSNIKALYEAVELERTGQSEFGAARR
Cofactor: Binds 1 Fe cation per subunit. Function: Required to synthesize hydroxyphenylglycine, a recurring skeletal component of nonproteinogenic macrocyclic peptide antibiotics such as vancomycin. Catalyzes the conversion of p-hydroxyphenylpyruvate to p-hydroxymandelate. The decarboxylation and hydroxylation activities of HmaS show novel and distinct regioselectivity, compared to all other known p-hydroxyphenylpyruvate dioxygenases, by hydroxylating the benzylic position of the substrate instead of the phenyl ring. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2 Sequence Mass (Da): 38339 Sequence Length: 357 Pathway: Antibiotic biosynthesis; vancomycin biosynthesis. EC: 1.13.11.46
Q6NT76
MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPQPCTTNQNGRENNERLSTSNGKMSPTRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATSGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAVEMAAVNHTILALARQGANEIKTEALDDD
Function: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination . Might also be involved in the DNA damage response at telomeres . Sequence Mass (Da): 47278 Sequence Length: 420 Domain: The homeobox domain is required for binding to 5'-TTAGGG-3' repeats in telomeres, and for telomere localization. Subcellular Location: Nucleus
Q12039
MDKLTPSQWKVINKSYEPASTIKVIAGPGSGKTLTLLYKVLHLITVENIKPEEILIFSLTNKAVDSIIENLLSIFENSHTNKEIVHQIGCYTVHGLANRIVVENEGMINIIEEIGWRGLMKLLPPSKRTPHHFRSYKELEKVVKDYKLNNAKNNNPVIEKLVELMDNCKVMTNDDLIIRAKKYLELDSSDSDASSFTQDLRNKYKVVLIDEFQDLYPSLAPLITMICKGKQLIMFGDTNQSIYGFLGSNNEIMSQLDNLHPKNSTTVLKLFDNFRSTPEIISLASKIINRPLAEKQIIDDTDETPSELVRKLPSGVSPQIMTFDDLAAESEFIIDKITQLICSSAKFSDIAILSRTNSHLTAIASILKKYGIPYQKLKSQPDWMDDLRIQFLLDILKVCSLASDEKHNREFNTGDKWQSNFSILVTMSALKGIGDASIQALYKACSLKNLSIWKYLTMVPNFEWPLGLSIKKKMENYTSNLYEMIENDQVHQLDDPMELLEKVASITNNLNLNPTYFQSLSDAQSSLEFKTHLQEMAQVMKVSKSNKPPGISFVKWFLETYFDQTMVFHQSQQALQTTGPGTVKLSTIHSAKGLEFPIVFLTNGSMSNFPMDTNALYVGITRARNLLYMCNMKHERLVSKSSPYSRNIMSNNLFWTYYNKDLKRSVCDVKVTHGYNVQRYNQLRKNFGFYRAYSSLRGCKSVFRRI
Function: Required for mitochondrial genome maintenance and mitochondrial DNA inheritance. Catalytic Activity: Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction. Location Topology: Peripheral membrane protein Sequence Mass (Da): 80576 Sequence Length: 706 Subcellular Location: Mitochondrion inner membrane EC: 5.6.2.4
Q9V3U0
MNDLKPATSYRSTSLHDAVKLRLDEPSSFSQTVPPQTIPEFFKESCEKYSDLPALVWETPGSGNDGWTTLTFGEYQERVEQAALMLLSVGVEERSSVGILAFNCPEWFFAEFGALRAGAVVAGVYPSNSAEAVHHVLATGESSVCVVDDAQQMAKLRAIKERLPRLKAVIQLHGPFEAFVDHEPGYFSWQKLQEQTFSSELKEELLARESRIRANECAMLIFTSGTVGMPKAVMLSHDNLVFDTKSAAAHMQDIQVGKESFVSYLPLSHVAAQIFDVFLGLSHAGCVTFADKDALKGTLIKTFRKARPTKMFGVPRVFEKLQERLVAAEAKARPYSRLLLARARAAVAEHQTTLMAGKSPSIYGNAKYWLACRVVKPIREMIGVDNCRVFFTGGAPTSEELKQFFLGLDIALGECYGMSETSGAITLNVDISNLYSAGQACEGVTLKIHEPDCNGQGEILMRGRLVFMGYLGLPDKTEETVKEDGWLHSGDLGYIDPKGNLIISGRLKELIITAGGENIPPVHIEELIKKELPCVSNVLLIGDHRKYLTVLLSLKTKCDAKTGIPLDALREETIEWLRDLDIHETRLSELLNIPADLQLPNDTAALAATLEITAKPKLLEAIEEGIKRANKYAISNAQKVQKFALIAHEFSVATGELGPTLKIRRNIVHAKYAKVIERLYK
Function: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation . Probably by regulating lipid storage and catabolism, plays a role in neuronal function . Catalytic Activity: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate Sequence Mass (Da): 75152 Sequence Length: 681 EC: 6.2.1.3
Q7W025
MTLQARNLTLARGGAPILTDVSLTLAPGALVGLLGANGAGKSTLLAALAGELAPRSGQVFLGDADLATLSARQLARRRAVLPQKPSLSFDLGVSDVVGMGAYPFPELDPAAVRQLVRDALEQAGVTHLAQRRYPQLSGGEQQRVQFARVLAQCHAMHAPGQTRYLMLDEPISNLDPRHQMELLATARALAHEAGMGVLVIVHDINQAARWCDTLALLADGRLAALGPPADVLTPDHMRRVYGIEADVLAHPTLPGRLLVLAR
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 27800 Sequence Length: 262 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q93SH7
MSAVIEARHLSKRAGRAKLLDGVGLTVAAGEMVAIIGPNGAGKSTLLRLLSGDLRPSQGEVWLKQRDIGSYTPRELAARRAMLSQHINVTFPFTVEEIVLMGAGDRSAREAGRLVDAALDEVGLAHFRERQLPTLSGGEQQRAHFARVLVQLACGEAEHGPGLLLLDEPTSSLDLRHQIDLVEAARRRAGTGTAVIAILHDLNLAIRFADRLVVLSGGKLAADGPRTEVVTRETIRDIFEIDAVVHQADGVPYVLPQSMRAAASAARI
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28745 Sequence Length: 268 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q62A98
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPRLARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTHADGEIASQALALAGATALDARDVTTLSGGELARVQFARVLAQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPADVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28401 Sequence Length: 272 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q9RZU5
MTASSPSIRVTDLSYSVAGRELLSKLKFHLQSGEMLAVLGRNGAGKSTLLKHLTGELGKSGVELFGQPLRDIKPAEAAKRRAVLPQQTPLSFAYEVLDVVLLGRIPHGQRETVQDRAIAAACLERVGLSGYETRDVLTLSGGEQQRVHFARTLAQLHGVIGERVLLLDEPTASLDLAHQHATLRLARELCREGVGVLAVLHDLNLAAQYADRVLMLAEGHVIACDHPAVALTPESIRTAYGHEVLVTQHPCLNCPLIVSAS
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28142 Sequence Length: 261 Subcellular Location: Cell membrane EC: 7.6.2.-
Q0TBU8
MISAQNLVYSLQGRRLTDNVSLTFPGGEIVAILGPNGAGKSTLLRQLTGYLQPDSGECRLFNKPLNEWSITELAKHRAVMRQNSHMAFPFSVQEVIQMGRHPHRTGNQDNETAQIMALCDCQALANRDYRQLSGGEQQRVQLARLLVQLWEPTPSPKWLFLDEPTSALDIHHQQHLFRLLRQLVHERQFNVCCVLHDLNLAARYADRVVLMQKGKVIANGKPQDVLTQQALTMLYGADITVLKDPANHSPLIVLDH
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28881 Sequence Length: 256 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q1R597
MISAQNLVYSLQGRRLTDNVSLTFPGGEIVAILGPNGAGKSTLLRQLTGYLQPDSGECRLFNKPLNEWSITELAKHRAVMRQNSHMAFPFSVQEVIQMGRHPHRTGNQDNETAQIMALCDCQALANRNYRQLSGGEQQRVQLARLLVQLWEPTPSPKWLFLDEPTSALDIHHQQHLFRLLRQLVHERQFNVCCVLHDLNLAARYADRVVLMQKGKVIANGKPQDVLTQQALTMLYGADITVLKDPANHSPLIVLDH
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28880 Sequence Length: 256 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q84EY8
MAERYTAENLTFTRSGRTLTDNVSLSLSQGELVTLIGPNGAGKSTLLRLLTGYLKPDSGGCSLAGKALDEWHPQTLSRYRAVMRQQSQPGFDWQVEEIVGMGRAPWTRHPEPSIVREVLQLTGCLPLAGRRYHALSGGEQQRVQLARALAQLGVTERRAAWLFLDEPTSALDLYHQQHLLRLLKSLTRQGHLHACVVLHDLNLAALWSDRILLLHNGRIVSQGIPETVLQADALAHWYGAQVHVGMTSGARRTAGFSRPLA
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28817 Sequence Length: 261 Subcellular Location: Cell inner membrane EC: 7.6.2.-
P52708
MAVFISSSGSPGRATATTTTTTTLLLAVLAAAAAAGLLLAPVAARGSPPEHDKQLQLQQQEDDRIPGLPGQPNGVAFGMYGGYVTIDDNNGRALYYWFQEADTADPAAAPLVLWLNGGPGCSSIGLGAMQELGPFRVHTNGESLLLNEYAWNKAANILFAESPAGVVFSYSNTSSDLSMGDDKMAQDTYTFLVKWFERFPHYNYREFYIAGESGHFIPQLSQVVYRNRNNSPFINFQGLLVSSGLTNDHEDMIGMFELWWHHGLISDETRDSGLKVCPGTSFMHPTPECTEVWNKALAEQGNINPYTIYTPTCDREPSPYQRRFWAPHGRAAPPPLMLPPYDPCAVFNSINYLNLPEVQTALHANVSGIVEYPWTVCSNTIFDQWGQAADDLLPVYRELIQAGLRVWVYSGDTDSVVPVSSTRRSLAALELPVKTSWYPWYMAPTEREVGGWSVQYEGLTYVSPSGAGHLVPVHRPAQAFLLFKQFLKGEPMPAEEKNDILLPSEKAPFY
Function: Involved in cyanogenesis, the release of HCN from injured tissues. Is involved in the catabolism of the cyanogenic glycoside dhurrin. PTM: The N-terminus of chain A is blocked. Catalytic Activity: (S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide Sequence Mass (Da): 56319 Sequence Length: 510 EC: 4.1.2.11
Q9LFT6
MERKHHFVLVHNAYHGAWIWYKLKPLLESAGHRVTAVELAASGIDPRPIQAVETVDEYSKPLIETLKSLPENEEVILVGFSFGGINIALAADIFPAKIKVLVFLNAFLPDTTHVPSHVLDKYMEMPGGLGDCEFSSHETRNGTMSLLKMGPKFMKARLYQNCPIEDYELAKMLHRQGSFFTEDLSKKEKFSEEGYGSVQRVYVMSSEDKAIPCDFIRWMIDNFNVSKVYEIDGGDHMVMLSKPQKLFDSLSAIATDYM
Function: Involved in cyanogenesis, the release of HCN from injured tissues (By similarity). Displays R-selective hydroxynitrile lyase activity. Also accepts nitromethane (MeNO2) as a donor in a reaction with aromatic aldehydes to yield (R)-beta-nitro alcohols. Catalytic Activity: (R)-mandelonitrile = benzaldehyde + hydrogen cyanide Sequence Mass (Da): 29217 Sequence Length: 258 EC: 4.1.2.10
P52704
MAFAHFVLIHTICHGAWIWHKLKPLLEALGHKVTALDLAASGVDPRQIEEIGSFDEYSEPLLTFLEALPPGEKVILVGESCGGLNIAIAADKYCEKIAAAVFHNSVLPDTEHCPSYVVDKLMEVFPDWKDTTYFTYTKDGKEITGLKLGFTLLRENLYTLCGPEEYELAKMLTRKGSLFQNILAKRPFFTKEGYGSIKKIYVWTDQDEIFLPEFQLWQIENYKPDKVYKVEGGDHKLQLTKTKEIAEILQEVADTYN
Function: Involved in cyanogenesis, the release of HCN from injured tissues. Decomposes a varieties of (R) or (S) cyanohydrins into HCN and the corresponding aldehydes and ketones. The natural substrate of this enzyme is (S)-acetone cyanohydrin. PTM: The N-terminus is blocked. Catalytic Activity: a monosubstituted aliphatic (S)-hydroxynitrile = an aldehyde + hydrogen cyanide Sequence Mass (Da): 29228 Sequence Length: 257 EC: 4.1.2.47
P19807
MSIRNDNASGGYMQPDQSSNASMHKRDLRVEEEIKPLDDMDSKGAVAADGEVHLRKSFSLWSILGVGFGLTNSWFGISTSMVAGISSGGPMMIVYGIIIVALISICIGTSLGELSSAYPHAGGQFWWSLKLAPPKYKRFAAYMCGSFAYAGSVFTSASTTLSVATEVVGMYALTHPEFIPKRWHIFVCFELLHLFLMFFNCYGKSLPIISSSSLYISLLSFFTITITVLACSHGKFNDAKFVFATFNNETGWKNGGIAFIVGLINPAWSFSCLDCATHMAFEVEKPERVIPIAIMGTVAIGFVTSFCYVIAMFFSIQDLDAVLSSTTGAPILDIYNQALGNKSGAIFLGCLILFTSFGCVIACHTWQARLCWSFARDNGLPLSRLWSQVNPHTGVPLNAHLMSCAWITLIGLLYLASSTAFQSLITGCIAFLLLSYIIPVICLLAKKRNIAHGPFWLGKFGFFSNIVLLGWTVFSVVFFSFPPVLPVTKDNMNYVCVVIVGYTAYSILYWKYKGKKEFHALEESENEQAEYSNNFDTIEDSREFSVAASDVELENEHVPWGKK
Function: Sole choline transporter in yeast. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 62056 Sequence Length: 563 Subcellular Location: Membrane
Q7SYS9
MDSGLRSLLSDHSRYVESFRLFLQNSTEHQCMQHFIETKLPDIISSIGNDKPVIDVLGIGSGSGEIDLQMIAKIQARWPGVSINNQIVEPSAEQILGYKERVAKAPNLGYVTFSWHHQTSSEFEHRVTEDKQMTKYDFIHMIQMLYYVKDVPGTLKFFKSCLAPNGKLLIILVSGNSGWAPLWKKYGQRLPLNDLCLYVTAGDIAEMLSSMGARFQSHELQSDMDITKCFIEGDKNGELLLDFLTETCDFRKNAPAELRDQIICDLKSPRCSTTKDGKVIFNNNLSVIVVEAD
Function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Catalytic Activity: histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine Sequence Mass (Da): 33060 Sequence Length: 293 Subcellular Location: Cytoplasm EC: 2.1.1.8
U3NEE3
MEPTPEMKRNRLPSMNFEAEILADPHDNSELYVIPSMRSLTAEEYVEAFQSFLDHSTEHQCMDEFNKEVMPHIMAGLGNGKSTINILGVGSGTGEQDLKMIQILQAAHPGVLINNEIIEPNPQHVAAYKELVNRAPDLQGVSFTWHQLTSSEYEQQVKEKNTHKKFDFIHMIQMLYRVEDIPNTIKFFHSCLNHQGKLLIIILSDSSGWASLWKKYRHCLPSTDSGHYITSDSITAVLRKLGIKYHVYEFPSGWDITECFIEGDPAGGHMMDFLTGTKNFLGTAPAALRSRLQEALCQPECSSRKDGRVIFCNNLSMIVAES
Function: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Catalytic Activity: carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 36375 Sequence Length: 322 EC: 2.1.1.22
P21526
MQDSHGNTQILNQANSMVKRTWRLLFRIATLILLVSIFVLSLIIVLQSTPGNLQNDINIIRKELNELMENFETTSKSLLSVSNQITYDVSVLTPIRQEAIETNIISKIKDHCKDRVIKEGSTCTLNRSPLHDVSFLNGFNKFYFTYKDNMQIKFKSLLDYPNFIPTATTPHGCIRIPSFSLGQTHWCYTHNINLLGCADPASSNQYVSLGTLQVLKMGDPYFKVEHSHYLNDGRNRKSCSVVAVPDGCLRNCVTMTKNETENFKDLNWQHNYLHTYHIMVPLKTRIINPPGSSRDWVHIAPGVGSGLLYAKLLIFPLYGGLTEKSVIHNNQSGKYFFPNSTKLQCRNSTMEKIKGAKDSYTITYFSGRLIQSAFLVCDLRQFLSEDCEILIPSNDYMMVGAEGRLYNIENNIFYYQRGSSWWPYPSLYRIRLNLSKKYPRITEIKFTKIEIAPRPGNKDCPGNKACPKECITGVYQDILPLSYPNTAFPHLKQAYYTGFYLNNSLERRNPTFYTADNLDYHQQERLGKFNLTAGYSTTTCFKQTTTARLYCLYIIEVGDSVIGDFQITLFLAA
Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Catalytic Activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 65544 Sequence Length: 573 Subcellular Location: Virion membrane EC: 3.2.1.18
P04850
MVAEDAPVRATCRVLFRTTTLIFLCTLLALSISILYESLITQKQIMSQAGSTGSNSGLGSITDLLNNILSVANQIIYNSAVALPLQLDTLESTLLTAIKSLQTSDKLEQNCSWSAALINDNRYINGINQFYFSIAEGRNLTLGPLLNMPSFIPTATTPEGCTRIPSFSLTKTHWCYTHNVILNGCQDHVSSNQFVSMGIIEPTSAGFPFFRTLKTLYLSDGVNRKSCSISTVPGGCMMYCFVSTQPERDDYFSAAPPEQRIIIMYYNDTIVERIINPPGVLDVWATLNPGTGSGVYYLGWVLFPIYGGVIKGTSLWNNQANKYFIPQMVAALCSQNQATQVQNAKSSYYSSWFGNRMIQSGILACPLRQDLTNECLVLPFSNDQVLMGAEGRLYMYGDSVYYYQRSNSWWPMTMLYKVTITFTNGQPSAISAQNVPTQQVPRPGTGDCSATNRCPGFCLTGVYADAWLLTNPSSTSTFGSEATFTGSYLNTATQRINPTMYIANNTQIISSQQFGSSGQEAAYGHTTCFRDTGSVMVYCIYIIELSSSLLGQFQIVPFIRQVTLS
Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Catalytic Activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 62205 Sequence Length: 565 Subcellular Location: Virion membrane EC: 3.2.1.18
P04853
MDGDRGKRDSYWSTSPSGSTTKPASGWERSSKADTWLLILSFTQWALSIATVIICIIISARQGYSMKEYSMTVEALNMSSREVKESLTSLIRQEVIARAVNIQSSVQTGIPVLLNKNSRDVIQMIDKSCSRQELTQHCESTIAVHHADGIAPLEPHSFWRCPVGEPYLSSDPEISLLPGPSLLSGSTTISGCVRLPSLSIGEAIYAYSSNLITQGCADIGKSYQVLQLGYISLNSDMFPDLNPVVSHTYDINDNRKSCSVVATGTRGYQLCSMPTVDERTDYSSDGIEDLVLDVLDLKGRTKSHRYRNSEVDLDHPFSALYPSVGNGIATEGSLIFLGYGGLTTPLQGDTKCRTQGCQQVSQDTCNEALKITWLGGKQVVSVIIQVNDYLSERPKIRVTTIPITQNYLGAEGRLLKLGDRVYIYTRSSGWHSQLQIGVLDVSHPLTINWTPHEALSRPGNKECNWYNKCPKECISGVYTDAYPLSPDAANVATVTLYANTSRVNPTIMYSNTTNIINMLRIKDVQLEAAYTTTSCITHFGKGYCFHIIEINQKSLNTLQPMLFKTSIPKLCKAES
Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. PTM: N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides. Location Topology: Single-pass type II membrane protein Catalytic Activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Sequence Mass (Da): 63410 Sequence Length: 575 Subcellular Location: Virion membrane EC: 3.2.1.18
P72849
MSVNLASQLREGTKKSHSMAENVGFVKCFLKGVVEKNSYRKLVGNLYFVYSAMEEEMAKFKDHPILSHIYFPELNRKQSLEQDLQFYYGSNWRQEVKISAAGQAYVDRVRQVAATAPELLVAHSYTRYLGDLSGGQILKKIAQNAMNLHDGGTAFYEFADIDDEKAFKNTYRQAMNDLPIDQATAERIVDEANDAFAMNMKMFNELEGNLIKAIGIMVFNSLTRRRSQGSTEVGLATSEG
Function: Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae. Catalytic Activity: heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] Sequence Mass (Da): 27051 Sequence Length: 240 EC: 1.14.14.18
P74133
MTNLAQKLRYGTQQSHTLAENTAYMKCFLKGIVEREPFRQLLANLYYLYSALEAALRQHRDNEIISAIYFPELNRTDKLAEDLTYYYGPNWQQIIQPTPCAKIYVDRLKTIAASEPELLIAHCYTRYLGDLSGGQSLKNIIRSALQLPEGEGTAMYEFDSLPTPGDRRQFKEIYRDVLNSLPLDEATINRIVEEANYAFSLNREVMHDLEDLIKAAIGEHTFDLLTRQDRPGSTEARSTAGHPITLMVGE
Function: Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae. Catalytic Activity: heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] Sequence Mass (Da): 28540 Sequence Length: 250 EC: 1.14.14.18
Q6D796
MAKKILLCDPTLRDGNHAVRHQLTRESFAAYCQAAEAANVPVVEVGHGNGLGASSMLVGECLLSDEDIFTISREHLHKSRMAIHLIPGFCTIKKDLTRALELGVDLFRVASHCTEADITDRHIHFVRNSGKEAWGILMMSHMTSPAVLLEEARKMESYGAEAIVIMDSAGAYFPDDVKERISTLVNGLTVPVGFHGHNNLGMSVINSVVAVQEGATIIDGTIRGFGAGAGNTQLEVLVAVFERLGYETGIDLYKILDAADIAEKGFNPVAPSISPLSIVSGLAGVFSGFAKPVAKAAKDYNVDPRDIFFGLGERKAVAGQESLIYEVARDLAKRNENSVEKGQ
Function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds. Catalytic Activity: (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate Sequence Mass (Da): 36890 Sequence Length: 343 Pathway: Aromatic compound metabolism; 3-phenylpropanoate degradation. EC: 4.1.3.39
P51016
MTFNPSKKLYISDVTLRDGSHAIRHQYTLDDVRAIARALDKAKVDSIEVAHGDGLQGSSFNYGFGRHTDLEYIEAVAGEISHAQIATLLLPGIGSVHDLKNAYQAGARVVRVATHCTEADVSKQHIEYARNLGMDTVGFLMMSHMIPAEKLAEQGKLMESYGATCIYMADSGGAMSMNDIRDRMRAFKAVLKPETQVGMHAHHNLSLGVANSIVAVEEGCDRVDASLAGMGAGAGNAPLEVFIAVAERLGWNHGTDLYTLMDAADDIVRPLQDRPVRVDRETLGLGYAGVYSSFLRHAEIAAAKYNLKTLDILVELGHRRMVGGQEDMIVDVALDLLAAHKENRA
Function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds such as phenols, cresols and catechols. Catalytic Activity: (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate Sequence Mass (Da): 37471 Sequence Length: 345 Pathway: Aromatic compound metabolism; benzoate degradation via hydroxylation. EC: 4.1.3.39