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B8NI20
MIENLRKRSTIEVEWRKQPVHMDIDLDQVDNPEAYPITVSVETSKDGSDPGLLWQPMHAERDSIVKETIHAKYVLGCDGARSWIRQRLGVSFIGDLTDSTWGVMDIVPKTSFPDIRKVAVIHSSKGTVMSVPREDKLVRFYIQIDAVNPNAASGLARRDLKVEDLLDAARAIMFPYTMEAAECAWWSAYRVGQRVANEFARHDRIFLAGDSVREYCLEVIRCQ
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors . N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline . Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation . The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH . Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins . Sequence Mass (Da): 25367 Sequence Length: 223 Pathway: Secondary metabolite biosynthesis. EC: 1.-.-.-
B8NI21
MTAPADSTEKSETSETTTLQTTEVSTVDVDPDLPRVLAKVPGTVWVVAFIAAAERFTYWGITTPWQLHAKPPQASEFARCIRPRRSESIHDIQCLHVFLLFNTNSFRDNLGRLSRSLSDIAPEFDKRFRKLPPTGNILPKAGSVLSCAIRGRFQLDAAMPSYQREHFAKEVSWDETFVNEIRRGLVACRVILGFILFFTCLSQASNNLISQAGQMKTYGIPNDTITAMNPIFCVIMGPVIQKGLYPLLNKNNVKFQSITRMATGFIMMSASMAFAAGVQKIIYDTGPCYDRPLTCPGAENGRIPNQVNVFLQTPTYIILAVAEIFSFVTLSEYTYTKAPTDMKAVVQALGQLGAAAGSAIGIAITPLAHDPSLIWMYTGLAVAMFLVAVVFWILFKKYNAIDREDK
Function: Peptide transporter; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44932 Sequence Length: 406 Subcellular Location: Membrane
B8NI22
MTMLSDLPKIPTLDWADFAEGDTDQRLKLAQGLVQGFKRFGFVKLVNHGLSDELIQQLFAEVKRFYRLPDELKQKAAHPPGPNPQRGWSGIGVESTSKLYGEQTERPSGKLKDAKVGTDFSSSKLSRELTHMKEHYDIGPPTDTQFPTRWPDEQDIPGWRAFMESYYARGQSFCLDLMEALEIGLELPKNTLRSMCIPDGSELRLLHYPEIPAAELRTGDTARIWPHTDFGLITLLFQDGVGGLEVEDPLQQGHYIEVAREQPYEMIVNVSATFERWMNGVIKAAVHRVNITPEGKHVEDAVVPERWSAAYFFKAHKMAHAGPLPAFVTPERPALYDNITALEFQKRRTDLVYTGQQLKVEEAA
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: 2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors . N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline . Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation . The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH . Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins . Sequence Mass (Da): 41194 Sequence Length: 364 Pathway: Secondary metabolite biosynthesis. EC: 1.14.-.-
B8NI23
MMTEAQGPVVSIGSATVTYDHPPIISPVSYPKARPTQILDIRKRTSRIDLYHEILAGLRAKDKELPSLLLWNDRGLDLFSEILNSDEYYPRRRETQLLQTHVNEFTRSISSGERLIELGAGNLQKTVSVLRCLEQSRKHVEYCALDVSHAALQASITELKAQLPFASYVTIRGLLGTYNDCASWLKQSGATVRTTFLWLGNSIANFEPEDATSILADFLQTKASPSHSPQMIIAVDGCQDVEQILEAYDMPNKLSQKFVFNGLSHANQILGSEVFRPQHWTFEGKWNPVKSMHESFYVAKKPMSLDIGNERFHVHAGEKIRAITSGKWPKDKVTSICQSAGIKVLKGWTDEEGSYGKRVTQVYSRGSSC
Function: N-methyltransferase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors . N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline . Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation . The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH . Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins . Sequence Mass (Da): 41349 Sequence Length: 369 Pathway: Secondary metabolite biosynthesis. EC: 2.1.1.-
B8NI24
MTATTTTTSQIFVSEDYNQDPNWYAVDNYTLSHLQPPTRPNHASLHQTLENSAKRGLEDISAFPTQAKFMALQCQLGGVKHALEVGTLGGYTAIYIASLNPDIRIVSIEIDPKSAEVAKENIAAAGYQDRIEVLVGAAIDLLPILQAKVENGEQERFGFTFIDANKDNGWDYFDYAVKMSRPRASIIVDNVVRAGKLVQEDYIKNDINVRGSRRTVENVGKDDRVDAVVLQTLSEKSYDGFLMAVVK
Cofactor: Binds 1 divalent metal cation per subunit. Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors . N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline . Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation . The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH . Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins . Sequence Mass (Da): 27359 Sequence Length: 247 Pathway: Secondary metabolite biosynthesis. EC: 2.1.1.-
B8NI25
MPAPKSIIIVGSGVFGLSTAHAMSQNNEFASSKITLIDSWNFEPSGPSASAPNPSAANFDTSRIIRSDYSHRTYATLAREAQQKWKADWGADGRYRNQSIVMIGEGHSMKQPMKALESINYVKHAYAQSYERAGRNSDIVHILDSESAVWEALGLGTPDEASKAGPNASELRGYRNHNCGWAESGATMAWLRQKTIHSDRIDIHIGQVVGLRVCSDSPSESHVNAEPRVCGVILDDGSQLTADLTVLAAGAMTPRLLGSPTLCDVYSETVAYVQLTEMERRELVRREFPLIVNVARKIFAIGPDNQGFLKLARFSWSGYRDVQKFAGVDVGPRSQAAPQEEDGYGACGDLDQTKLSPDVESTLQDYRGFLRELFRSGDGGDLGGLRNIATRPFAQVRRCWYADTVSTDFIVDYHPAYGKSLFIATGGSDHAFKFLPVLGERICELILQSDNGKAGPSESIQELQRLWKFPGGDSHAKL
Function: Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors . N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline . Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation . The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH . Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins . Sequence Mass (Da): 52382 Sequence Length: 478 Pathway: Secondary metabolite biosynthesis. EC: 1.5.3.-
B8NI27
MVNQAFMLWCYITPVLGAVVAEQYIGRVKTIIFSSSVYLCGLVTLFLSSLPTAYAMGISLPGLLVSLFLIGIGTGGIKTNVSSLIAEQYTGPKESRRILKSGEEVIVDRDLTIQRIFTTFFLYINIGSFSPLLITIIEKEYGFSAAFSLSAITFSIGFIIVLVSRHLYISRDPDSSIIFNACKAFWIAIKHKGNLDYARPSYQTEQAATRRLSWDDSFIDDLRRAIASCKIFILYPIYWAAYSQFLTNFISQAATMETHGVPNDIMTNIDPITVLILLPVLDRIVFPFLRRQGVPVRHVDRITIGMPDFQPFVQESYQICQRTCFQIISAIELGLGLQAGRLTQCCQPAASEIRLLYYPPTTKNLFDEGLKKRAWPHTDLGIITLLFQDMVGGLEVEDRAAGKPRSFIPVKRVSPNEMIVNTSDSLQRWTNNVIRAGLHQVTAPDAAKLSNGVDMLPARCSSVFFFKAGRDTSVGPLPEFVTEDRPAAFEDMTALQYQQLKTRILHGVEG
Function: Peptide transporter; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56962 Sequence Length: 510 Subcellular Location: Membrane
A0A0D4BS77
MTRTDFAQSAVASIFTGAIASHAAVLADDLGLFDALAKGKLRNRDLDRSPWLRNRIRISGALEALCRVGAVQRCTDGYELTDVGTELAGQVPVFRLWLGGYASVLAGQISIGADPATGVHGGIVAESSGAIGARYLDETIVNLLESLRPEGRICDIGCGTGARLLRVCRRVNQPGIGYDLSAKAVEAARETVDEARRIGVDIDVRQGDATALTQDHPDVDIVTQAFMTHHIAPDEYCAAVLRSYRSRFPRARYLVIFDTVPSQDSEEPEIFAPGFDYIHALQNMEPRSRGAARRMFTEAGYICREEVELAVPNSYAWVLEMRDREGPAS
Function: Involved in the biosynthesis of the antibiotic indolmycin, an inhibitor of the bacterial tryptophan-tRNA synthetases. Catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to position 3 of the aliphatic side chain of (indol-3-yl)pyruvate to yield 3-methylindolepyruvate. Catalytic Activity: indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine Sequence Mass (Da): 35840 Sequence Length: 329 EC: 2.1.1.47
Q6CE48
MRGFRLIAPIQRSIAIISRLQPITANFHSSPALRSHENPLGIPKSPASAPRIPRKTTRRPEPIAGVKKTIVVSSAKGGVGKSTVSVNTALSLAKRGLRVGLLDVDIFGPSIPTMFGLSGEPRMTHEGKLIPMSKFGIQVMSMGFLVDPNKAVAWRGLLVQKALEQLLQDVDWGTLDVLVMDLPPGTGDVQLTIAQTVKIDGAIIVSTPQDVALVDVVRGLDLFEKTYTKVLGLVQNMSVFVCPNCNHETHIFGVDGAVSKAKSRGLGVLGNVPLDPQICSQSDKGVPVAVSGGVQAKYYDKIAEGVAEQLGV
Cofactor: Binds 1 [4Fe-4S] cluster. Function: Required for the effective assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Probably facilitates the assembly of Fe-S cofactors and subunits of complex I. Location Topology: Peripheral membrane protein Sequence Mass (Da): 33167 Sequence Length: 312 Subcellular Location: Mitochondrion inner membrane
A0A0D4BSN8
MKLDDKRILIIGAGEVGTAVAEDLVNRSDPTEIIIHTSRQQTMDMRVGHLKEMAGPRTLLTGSWGDIFAPYELTHRSRSEINDRNVRLALAEFFLQPSGEAQLRRTTIYELISRHRPHIVIDAVNSASVCTYTEDPHQTCGELLDLARGTGGPRTAEAPAELPAVTPDIADVATDALLSLSTPILHRYVDSLRRAMADFQVERFIKVSTTGLGGMGYNCPYTHGSVTEFGLSDALVGKIGSAGVLHQLLWNLHHTAGCDVRLVIPAALIGWESVRHGAYTSRGRPVALQDCSRPLPLHLDRPLGEHAAASSVAEPAAEDEPSAEMVHVPAGDNSTYSRAEMSLSTALGQFESVTREEVAAAVLDTLLGSTRFDLFTAMDTASLQSSYLAAQMRTSTLTSMRQLEKAYDRPSIVSGNLGPTISKDLLELHVLCTAAGSLEQARTMSTTVLASSASALVREDVYLRQQALSIGLAVLLPDDQWLAGPRLSVPSRIDPEAKVTRADIDDWSRQGWVDLRPARILHWQENLRRIEQDASAGKTAFALDDTAYDVGEVLAYHYKLTGQARRIKGL
Function: Involved in the biosynthesis of the antibiotic indolmycin, an inhibitor of the bacterial tryptophan-tRNA synthetases. Catalyzes the NADH-dependent reduction of beta-methylindolepyruvate to yield indolmycenate. Catalytic Activity: (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH Sequence Mass (Da): 62085 Sequence Length: 570 EC: 1.1.1.397
A0A0D4BSP3
MHTDWETSESAEDYSRNTAAAQWEPMGYPAVFRSLALATTDSDNAPPILDYGCGPGFVDRHVAEKYGRRVIAVDISSSMIDLARSQHSHPLVTYRHVPDSQLDFLGDKEIGGCMSCFVLMQMADSDTQVEICRRIRRTLAPGAMLAVLNTHPDSVGIQFATLRNGEPDRVYQPGDPMTTVLTTDKGVLRLQDYYWRVTDYVHALEAAGFHEVTVEHLPPPPADPTPHPQFLLVRGTA
Function: Involved in the biosynthesis of the antibiotic indolmycin, an inhibitor of the bacterial tryptophan-tRNA synthetases. Catalyzes the methylation of N-demethylindolmycin to yield indolmycin, with S-adenosylmethionine (AdoMet) acting as the methyl donor. Catalytic Activity: N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine Sequence Mass (Da): 26296 Sequence Length: 237 EC: 2.1.1.328
O49472
MATVALLRSLRRRELHAAHISAYKFSSASAGGRTTELRLHGVKDIIAVASGKGGVGKSSTAVNLAVALANKCELKIGLLDADVYGPSVPIMMNINQKPQVNQDMKMIPVENYGVKCMSMGLLVEKDAPLVWRGPMVMSALAKMTKGVDWGDLDILVVDMPPGTGDAQISISQNLKLSGAVIVSTPQDVALADANRGISMFDKVRVPILGLVENMSCFVCPHCNEPSFIFGKEGARRTAAKKGLKLIGEIPLEMSIREGSDEGVPVVVSSPGSIVSKAYQDLAQNVVKGLKELRENPDNEIQMKLNVPHSSHSS
Cofactor: Binds 1 [4Fe-4S] cluster. Function: Essential during early vegetative growth . Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) . Involved in mitochondrial translation activity . May deliver of one or more Fe-S clusters to complex I subunits (By similarity). Sequence Mass (Da): 33426 Sequence Length: 313 Subcellular Location: Mitochondrion matrix
Q9VVT2
MATETTKMIYTPPPLDIKMEIEIGEQPQPPVKCSNFFANHWKGLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGVCKINHEPQYQIVGGNKKNNEDEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGWADLLNSKDIRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPTIITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAAAALGNKTH
Function: Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 65585 Sequence Length: 590 Subcellular Location: Basolateral cell membrane
Q9VDQ0
MAEPGEQRKFVLGRCCIFHWRGKASIIIPLITLPILIYGFQTDMAEFKCLWLIVTMALLWITETLPIYVTALFPLVFCPLLGLVNASIVCKQYFTDTIVVFLGGLIVALGIEYSNLHTRIALRVIRIVGGSPRRLFVGLMSVSTFMGLWISNSAGTAMMCPIVKALVNELDTNKIFPVYMTQEEEPVEEGEPPHPSKITVAFYAGIAYASSIGGLGTLIGTGTNLVFRGIYTERFPTSTVEITFANFMFYSIPLMVIVNVTLVIIAFLITHMGLFRPNSKTGKIIAEANTNRKLMEDVLRQRHIDLGPMSCHEIQMAIAFAFMIVLLITRKPGFVPGWSDLINRKVVGSASGLSFIVLLIFALPTQYTFFKYCCGKGPFTAQAIDAILSWEYVLRNIPWGLLFLLGGGFALAVASRETGLNIMISKAMQVLIGLPNIVVQSITFVLANFFSAFNANVVVANIVLPILCEMSLALELHPLILTLPACLGISMVYFLPVSTPPNAIVTQYAHIKTKYFACCGIVPTIIGISVALVNTNTWGLIIFPESKSFPDWAKEIKNQTKI
Function: Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 61935 Sequence Length: 562 Subcellular Location: Membrane
Q9VR07
MAENKDVSQVLNTTPDQVVINRAPPTGLAPLRHSQLSDSGAESCYEGDEQARLIRSSSSRAHKFIIIPATPGTPPGSGAVAGPLPFRQTSSTTSLAAMAAALHKQSPLRHTSVRTRPSSEVLQPGQVLANQPTAAVSTSTVTFTIDDCNEEGDAIPAAASVPAPVTMPAISPTPATLTCTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPNPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSLASIGIGSTDGRKLVIRRVPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLAQEMATVYKPTNPHLLNLGQKCGYNAMQASPSHAEAGGPCGQ
Function: Plays a role in neuronal membrane excitation, important for normal response properties of the photoreceptor. Able to control excitability from either neurons or glia cells. Ine negatively regulates neuronal sodium channels. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve, ine and eag control perineurial glial growth through partially redundant pathways. Isoform A and isoform B are both functional, although isoform A functions with greater efficiency. Has a role in osmolyte transport within the Malpighian tubule and hindgut. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 103636 Sequence Length: 943 Subcellular Location: Membrane
P42801
MFIESFKVESPNVKYTENEIHSVYDYETTEVVHEKTVNGTYQWIVKPKTVKYDFKTDIRVPKLGVMLVGLGGNNGSTLTAGVIANKEGISWATKDKVQQANYFGSLTQASSIRVGSFNGEEIYAPFKSLLPMVNPDDVVFGGWDISDMNLADAMARARVLDIDLQKQLRPYMENIVPLPGIFDPDFIAANQGSRANHVIKGTKKEQVDHIIKDMREFKEKNKVDKVVVLWTANTERYSNVVVGMNDTMENLMESVDRDEAEISPSTLYAIACVLEGIPFINGSPQNTFVPGLIDMAIRNNVLIGGDDFKSGQTKMKSVLVDFLVGAGIKPTSIVSYNHLGNNDGMNLSAPQTFRSKEISKSNVVDDMVASNGILFEPGEHPDHVVVIKYVPYVADSKRAMDEYTSEIFMGGKNTIVMHNTCEDSLLAAPIILDLVLLAELSTRIQFKSEGEGKFHSFHPVATILSYLTKAPLVPPGTPVINALSKQRAMLENIMRACVGLAPENNMIMEFK
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner . Catalyzes the majority of myo-inositol synthesis required for plant growth and development . Acts as a repressor of programmed cell death and protects plant cells against cell death under high light intensity or long days . Controls its own transcription by inhibiting ATXR6 activity . Reduces the deposition of inhibitory histone marks on its own promoter . Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 56515 Sequence Length: 511 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Subcellular Location: Cytoplasm EC: 5.5.1.4
Q8A7J8
MKQEIKPATGRLGVLVVGVGGAVATTMIVGTLASRKGLAKPIGSITQLATMRMENNEEKLIKDVVPLTDLNDIVFGGWDIFPDNAYEAAMYAEVLKEKDLNGVKDELEAIKPMPAAFDHNWAKRLNGTHIKKAATRWEMVEQLRQDIRDFKAANNCERVVVLWAASTEIYIPLSDEHMSLAALEKAMKDNNTEVISPSMCYAYAAIAEDAPFVMGAPNLCVDTPAMWEFSKQKNVPISGKDFKSGQTLMKTVLAPMFKTRMLGVNGWFSTNILGNRDGEVLDDPDNFKTKEVSKLSVIDTIFEPEKYPDLYGDVYHKVRINYYPPRKDNKEAWDNIDIFGWMGYPMEIKVNFLCRDSILAAPIALDLVLFSDLAMRAGMCGIQTWLSFFCKSPMHDFEHQPEHDLFTQWRMVKQTLRNMIGEKEPDYLA
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner. Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Location Topology: Single-pass membrane protein Sequence Mass (Da): 48398 Sequence Length: 429 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Subcellular Location: Membrane EC: 5.5.1.4
Q2NL29
MEAATEFVVESPDVVYSPETIEAQYEYRTTSVSREGGVLKVHPTSTRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRTGRKEANYYGSLTQAGTVSLGLDAEGKEVFVPFSSLLPMVAPDDLVFDGWDISSLNLAEAMRRAQVLDWGLQEQLWPHMEAMRPRPSVYIPEFIAANQSARADNVIPGTRAQQLEQIRRDIRDFRFSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIQLGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQRRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPPQFRSKEVSKSSVVDDMVHSNPVLYSPGEQPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDVDPDPQSFHPVLSLLGFLFKAPLAPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGLKRVGPLATTSPVLCKKGSAPTAPNGCTGDANGHSQAEAPQMPTT
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner . Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 60761 Sequence Length: 557 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Subcellular Location: Cytoplasm EC: 5.5.1.4
Q8NLE6
MSTSTIRVAIAGVGNCATSLIQGVEYYRNADPSETVPGLMHVKFGDYHVGDIEFVAAFDVDAEKVGIDLADATEASQNCTIKIADVPQTGINVLRGPTLDGLGDHYRATIDESTAEPVDVVQALIDAKADVLVSYLPVGSEEADKFYAQAAIDAGCAFVNALPVFIASDPEWAKKFTDAGIPIVGDDIKSQIGATITHRVLARLFEERGVRVDRTMQLNVGGNMDFKNMLDRNRLESKKVSKTQAVTSNIPDGPLSGKVEDRNVHIGPSDHVQWLDDRKWAYVRLEGTAFGGVPLNLEYKLEVWDSPNSAGIIIDAVRAAKIALDRGIGGPIMPASSYLMKSPPEQLPDDVARERLEAFIIEA
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner . Plays a key role in oxidative stress resistance as its product is the precursor of the protective antioxidant mycothiol (MSH or AcCys-GlcN-Ins) . Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 39223 Sequence Length: 363 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. EC: 5.5.1.4
J9VYL3
MSPTALDACDHHDSFSLPAQDQSKVHPSARRTPEGGLIKVESDSTVYEADGIKAKFTDRGASVIKGSDGKLSVKKTEKNFEFFTKSTVGRVGLMLVGLGGNNGTTVLATNLANKYNISWHTKNGIQQPNYIGSVVRASTVRLGTDPETGKDVFVPISDMLPMVHPNDFVIGGWDISSLSMDKAMLRAKVLEWDLQRQLIPLMENVKPLPSIYYPDFIAANQADRADNLIPGDDKKVHLEHIRADIRRFKADNHLDSVVVLWTANTERYADIIPGVNDTADNLLKAVETSHEEVSPSTIFAMASILEGVPFINGSPQNTFVPGCIELAEKHKAFIGGDDFKSGQTKVKSVLAEFLVNAGIKPLSISSYNHLGNNDGKNLSSQRQFRSKEISKSSVVDDMVAANPILYKTAEDLSKATGEIVKKGEHPDHIVVIKHVPAVGDSKRAIDEYYSELLMGGRNVMNIFNECEDSLLATPLIFDLAILAELLTRVTYRENATGEWQPLYSVLSLLSYMLKAPLVKPGEDVVNSLNRQRNALEQFLKACLGLEHSNDLLLNTRVW
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner . Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 61383 Sequence Length: 558 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Subcellular Location: Cytoplasm EC: 5.5.1.4
Q54N49
MSAQMFESFKVNSPNVKYTDEHIISDYTYQTTKVQNVNGELIVEPVDQKYIFKTERKVPRMGVMIVGLCGNNGTTVVGGVIANREGLCWNTKQGLQTPNYFGSVVMSSTIRMGMDENGCDAYIPLKNLIPMVHPNDIVFGGWDINNANLADAMQRAQVFDYDLQVQLIPHMKNITPLPSIYFPDFIAANQKDRANNVLTGTKKEQMEQIRKDIRDFKESNKLDTVVVMWSANTERFSSLVPGVNDTIENLMAAIDRSEEEISPSTLFAVASILENTTYINGSPQNTFVPAVVDLAIQHNVSIGGDDFKTGQTKIKSVLTDYLVSAGIKPVSIVSYNHLGNNDGKNLSAPQQFRSKEITKSNVVDDMIASNNILYKQGEHPDHVIVIKYVPYVGDSKRAMDEYTSQIFMGGHNTIVLHNTCEDSLLAAPIILDLVILAEVTSRITMKKQDDDQFATFHPVLSLLSYLLKAPIVPKHATVVNALFKQRACIENIFKACVGIAPDNNMLLEQRL
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 56847 Sequence Length: 511 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Subcellular Location: Cytoplasm EC: 5.5.1.4
O97477
MKPTNNSTLEVISPKVQVDDEFITTDYDYQTSHVKRTADGQLQVHPQTTSLKIRTGRHVPKLGVMLVGWGGNNGSTLTAALEANRRQLKWRKRTGVQEANWYGSITQASTVFIGSDEDGGDVYVPMKELLPMVEPDNIIVDGWDISGLHLGDAMRRAEVLDVALQDQIYDQLAQLRPRPSIYDPDFIAANQSDRADNVIRGTRLEQYEQIRKDIRDFRERSGVDSVIVLWTANTERFADVQPGLNTTSQELIASLEANHSEVSPSTIFAMASIAEGCTYINGSPQNTFVPGLIQLAEEKNVFIAGDDFKSGQTKIKSVLVDFLVGAGIKPVSIASYNHLGNNDGKNLSAPQQFRSKEISKSNVVDDMVASNRLLYGPDEHPDHVVVIKYVPYVGDSKRAMDEYTSEIMMGGHNTLVIHNTCEDSLLATPLILDLVILGELSTRIQLRNAEKESAPWVPFKPVLSLLSYLCKAPLVPQGSQVVNSLFRQRAAIENILRGCIGLPPISHMTLEQRFDFSTITNEPPLKRVKILGQPCSVESVTNGKKLHANGHSNGSAKLATNGNGH
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner . Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 62249 Sequence Length: 565 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Subcellular Location: Cytoplasm EC: 5.5.1.4
Q9NPH2
MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVFVPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNGCTGDANGHLQEEPPMPTT
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner . Rate-limiting enzyme in the synthesis of all inositol-containing compounds . PTM: Phosphorylation at Ser-279 and Ser-357 may be associated with a decrease in activity. Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 61068 Sequence Length: 558 Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Subcellular Location: Cytoplasm EC: 5.5.1.4
A0R7G6
MSEHAGEIRVAIVGVGNCASSLVQGVQYYRNADENTTVPGLMHVKFGPYHVRDVNFVAAFDVDAKKVGFDLSEAIFASENNTIKIADVPPTDVIVQRGPTLDGIGKYYADTIEVSDAEPVDVVKVLKEAEVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFEDAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVTLDRTYQLNVGGNMDFLNMLERSRLESKKVSKTQAVTSNLSGALAGKVEDKNVHIGPSDHVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPIEAASAYLMKSPPKQLADDVARAELETFIEG
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner. PTM: Pupylated at Lys-65 by the prokaryotic ubiquitin-like protein Pup, which leads to its degradation by the proteasome. Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 39300 Sequence Length: 363 EC: 5.5.1.4
P9WKI0
MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDAGVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner. Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 39994 Sequence Length: 367 EC: 5.5.1.4
P9WKI1
MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG
Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner. PTM: Pupylated at Lys-73 by the prokaryotic ubiquitin-like protein Pup, which leads to its degradation by the proteasome. Catalytic Activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate Sequence Mass (Da): 40094 Sequence Length: 367 EC: 5.5.1.4
P28999
MKFAYSLLLPLAGVSASVINYKRDGDSKAITNTTFSLNRPSVHFTPSHGWMNDPNGLWYDAKEEDWHLYYQYNPAATIWGTPLYWGHAVSKDLTSWTDYGASLGPGSDDAGAFSGSMVIDYNNTSGFFNSSVDPRQRAVAVWTLSKGPSQAQHISYSLDGGYTFEHYTDNAVLDINSSNFRDPKVFWHEGENGEDGRWIMAVAESQVFSVLFYSSPNLKNWTLESNFTHHGWTGTQYECPGLVKVPYDSVVDSSNSSDSKPDSAWVLFVSINPGGPLGGSVTQYFVGDFNGTHFTPIDGQTRFLDMGKDYYALQTFFNTPNEKDVYGIAWASNWQYAQQAPTDPWRSSMSLVRQFTLKDFSTNPNSADVVLNSQPVLNYDALRKNGTTYSITNYTVTSENGKKIKLDNPSGSLEFHLEYVFNGSPDIKSNVFADLSLYFKGNNDDNEYLRLGYETNGGAFFLDRGHTKIPFVKENLFFTHQLAVTNPVSNYTTNVFDVYGVIDKNIIELYFDNGNVVSTNTFFFSTNNVIGEIDIKSPYDKAYTINSFNVTQFNV
Function: Has both inulase and invertase activity. Catalytic Activity: Endohydrolysis of (2->1)-beta-D-fructosidic linkages in inulin. Sequence Mass (Da): 62214 Sequence Length: 555 Subcellular Location: Secreted EC: 3.2.1.7
O94220
MLNPKVAYMVWMTCLGLTLPSQAQSNDYRPSYHFTPDQYWMNEPNGLIKIGSTWHLFFQHNPTANVWGNICWGHATSTDLMHWAHKPTAIADENGVEAFTGTAYYDPNNTSGLGDSANPPYLAWFTGYTTSSQTQDQRLAFSVDNGATWTKFQGNPIISTSQEAPHDITGGLESRDPKVFFHRQSGNWIMVLAHGGQDKLSFWTSADTINWTWQSDLKSTSINGLSSDITGWEVPDMFELPVEGTEETTWVVMMTPAEGSPAGGNGVLAITGSFDGKSFTADPVDASTMWLDNGRDFDGALSWVNVPASDGRRIIAAVMNSYGSNPPTTTWKGMLSFPRTLSLKKVGTQQHFVQQPITELDTISTSLQILANQTITPGQTLLSSIRGTALDVRVAFYPDAGSVLSLAVRKGASEQTVIKYTQSDATLSVDRTESGDISYDPAAGGVHTAKLEEDGTGLVSIRVLVDTCSVEVFGGQGEAVISDLIFPSDSSDGLALEVTGGNAVLQSVDVRSVSLE
Function: Endo-inulinase involved in utilization of the plant storage polymer inulin, consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60. Catalytic Activity: Endohydrolysis of (2->1)-beta-D-fructosidic linkages in inulin. Sequence Mass (Da): 55793 Sequence Length: 516 Subcellular Location: Secreted EC: 3.2.1.7
Q96TU3
MAPLSKALSVFMLMGITYAFNYDQPYRGQYHFSPQKNWMNDPNGLLYHNGTYHLFFQYNPGGIEWGNISWGHAISEDLTHWEEKPVALLARGFGSDVTEMYFSGSAVADVNNTSGFGKDGKTPLVAMYTSYYPVAQTLPSGQTVQEDQQSQSIAYSLDDGLTWTTYDAANPVIPNPPSPYEAEYQNFRDPFVFWHDESQKWVVVTSIAELHKLAIYTSDNLKDWKLVSEFGPYNAQGGVWECPGLVKLPLDSGNSTKWVITSGLNPGGPPGTVGSGTQYFVGEFDGTTFTPDADTVYPGNSTANWMDWGPDFYAAAGYNGLSLNDHVHIGWMNNWQYGANIPTYPWRSAMAIPRHMALKTIGSKATLVQQPQEAWSSISNKRPIYSRTFKTLSEGSTNTTTTGETFKVDLSFSAKSKASTFAIALRASANFTEQTLVGYDFAKQQIFLDRTHSGDVSFDETFASVYHGPLTPDSTGVVKLSIFVDRSSVEVFGGQGETTLTAQIFPSSDAVHARLASTGGTTEDVRADIYKIASTWN
Function: Exo-inulinase involved in utilization of the plant storage polymer inulin, consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60. Splits off terminal fructose units successively from the non-reducing end of the inulin molecule, and also hydrolyzes levan, stachyose and raffinose. Catalytic Activity: Hydrolysis of terminal, non-reducing (2->1)- and (2->6)-linked beta-D-fructofuranose residues in fructans. Sequence Mass (Da): 59171 Sequence Length: 537 Subcellular Location: Secreted EC: 3.2.1.80
O05265
MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAAKHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKETEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFRSGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILSYDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPKPAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA
Function: Catalyzes the NADPH-dependent reduction of scyllo-inosose (SIS) to scyllo-inositol (SI) in vitro, but is unable to dehydrogenate scyllo-inositol and myo-inositol. Is less efficient than the functional paralog IolW. Under physiological conditions, may primarily function as an NADPH-dependent oxidoreductase that reduces carbonyl group(s) in its substrates. Cannot use NADH instead of NADPH. Catalytic Activity: NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose Sequence Mass (Da): 36515 Sequence Length: 328 EC: 1.1.1.371
O32223
MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKIMTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVMEKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVSYNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETVDYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPEDDSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEGINVIRIIEAAMESSKEKRTIMLEH
Function: Catalyzes the reversible NADPH-dependent reduction of scyllo-inosose (SIS) to scyllo-inositol (SI). Cannot use NADH instead of NADPH. May be involved in reduction of not only SIS but also various oxidized compounds manifested upon stressful conditions. Catalytic Activity: NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose Sequence Mass (Da): 40112 Sequence Length: 358 EC: 1.1.1.371
P40332
MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAEQVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTLSLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGAPPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALTYIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDIIPDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLDVKRAYTGM
Function: Catalyzes the reversible NAD(+)-dependent oxidation of scyllo-inositol (SI) to 2,4,6/3,5-pentahydroxycyclohexanone (scyllo-inosose or SIS). Is required for SI catabolism that allows B.subtilis to utilize SI as the sole carbon source for growth. Cannot use NADP(+) instead of NAD(+). Catalytic Activity: NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose Sequence Mass (Da): 37484 Sequence Length: 342 Pathway: Polyol metabolism. EC: 1.1.1.370
O28783
MLNDVVRDAEGEKVFLLGNEAIARGAIEAGIDVFAAYPGTPSSEIADTLSDACRLLRGKMDFYMEYSANEKVAFEVAVGASLAGKRAMATMKHVGVNVAADPLFSFAYVGARGGFVLVTADDPSMHSSQNEQDNRWYGKAAKLPVVEPSSVQEAKDYAKLCFDLSEKFGLPMILRSYTRLSHASGVVELGKIPEKEFSRVEWERHPETDVVLPAHARKLKPILLEKLEKIERYFNSSEMNWVDEGDGDVGIIACGLSYAYTKEALENLNLNLPVLKLSSMHPLPERLIENFVSQMKKVIVVEEVDPFVELHVRAMGLAEVYGKMNGYMPMNYEYNVGRVETGIAKALGIKPSRDYEGIVAESQKLAAKAPPRPPVLCPGCPHSASFYAIRRVVDELGDAALPSDIGCYTLGINKPLEGVDITICMGASVGVSNGLAHVLNNKIIATIGDSTFIHAGIPPLINAVYNHADFVLVILDNSTTGMTGHQPHPGTGFRGCGEAGKAVRIEDIVRGCGVEFVEVVNPYNVRKMVDVLRRALNHDGVAVVIARQPCAILWSRARRREGKIVTYKVTEDCTLCMECVNTFACPALIFDGEKVSIDQSLCVGCAVCAKICPNRAIKPAKSN
Cofactor: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP. Function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Catalytic Activity: CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 67798 Sequence Length: 623 EC: 1.2.7.8
Q51697
MIEFILNGQPVRVTEVPEDAPLLWVVREHLKLSGTKFGCGLGLCGACTVHINGEAARSCITPLSVVARQSVTTIEGLDPQHAHPLQRAWIAEQVPQCGYCQSGQIMQAAALLKKVPKPSDAQIVEAMDGNLCRCGTYQRIKIAIHRAAKEAA
Function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Catalytic Activity: A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one Sequence Mass (Da): 16410 Sequence Length: 152 EC: 1.3.99.16
P80910
MELDDILDAGRGDRLFLLGNEAAVRAAIESGVGVASTYPGTPSSEIGNVLSKIAKRAGIYFEFSINEKVALEVAAAAAASGVRSFTFMKHVGLNVASDSFMSVAYTGVRAGMVVLSADDPSMFSSQNEQDNRHYARLAWVPLLEPSNPQEILEYMNHAFELSEEYRIPVLLRTTTRVSHMRGVVEAGERRAEPVKGFFRKNPEQFVPVPATARVMRRELVEKMKKLKRVADTSELNRVLNEDSESDLGIIASGGAFNYVYDALQTLGLDVPVLKLGFTYPFPAGLVAEFLSGLEGVLVVEEVDSVMEKEVLAVATSEGLDVGVHGKLDGTLPEIYEYSEDIVRRAISGLTGIKSHEKGIEAPELPERPPALCPGCPHRAMYYSVRRAASELGIEGEDLIFPTDIGCYTLGIEPPYSAADYLLSMGSSVGTACGFSAATSQRIVSFIGDSTFFHAGIPPLINAVHNRQRFVLVILDNRTTAMTGGQPHPGLPVDGMGEEAPAISIEDITRACGVEFVETVNPMNIRRSSETIRRALQHESVAVVISRYPCMLSEGAVRGRPVRVDEEKCDLCLECLNELACPAIVEEDGRVFIDPLYCRGCTICLQICPAGAIKPEGKR
Cofactor: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP. Function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Catalytic Activity: CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 67098 Sequence Length: 618 EC: 1.2.7.8
O07835
MAKVTDIVLWDKPGERVLLLGNHAIARGALEANIAVFAAYPGTPSSELTDTMAAVAKKAGVYMEYSTNEKVAFETALAAAWSGLRAMTAMKHVGLNVAADSFLSSVGMGVEGGFVIMVADDPSMWSSQNEQDTRVYAKFANVPVLEPSSPHEAKEMTKYAFELSEKFKHFVILRTTTRSSHARGDVVLGELPEEIKTGKRKFGKFKKDPTRFVDVPAHARKFHPLILEKIEKIREELNNCPFNWIEGKEDAKVGIIAPGLSYAYVKEALAWLGVEDVKILKLGTPFPVPYGLLGKFFDGLEKVLIVEELEPVVEEQVKTWAYDKGLRIPIHGKDLVPRVYEMTTRRAVEAIAKFLGLETPINFAEIDEKYEKVSQIVPPRPPSLCPACPHRNSFFAIRKAAGPKAIYPSDIGCYTLGVLPPLRTVDTTVAMGASIGIGHGLSIAMNGSLAEEEHKEGKEKQIIVATIGDSTFYHTGLPALANAIYNRSNVLIVVLDNLVTAMTGDQPNPGTGQTPHGMGKRIPIEDVAKAMGADFVAVVDPYDIKATYETIKKALEVEGVSVVVSRQVCALYKIGQMRRRGMKWPIYHVVEDKCTGCKICINAYGCPAIYWDPETKKAKVDPTMCWGCGGCAQVCPFDAFEPMKEGE
Cofactor: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP. Function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Catalytic Activity: CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 70900 Sequence Length: 647 EC: 1.2.7.8
O28249
MRLNIVVVGVGGQGALTTSGIIARAAMRAGLNVVTAETHGMAQRGGSVEVHVRIGDVRAPLIPEGGADVMIALEPAEALRYAKFLNKNTLVILNTRKIIPPSVTAGTAKYPELDEIIGELRKVTPRVIPVNASEIAEKAGSVLATNVVVVGMLFGYYSMPFGIEHVEEAIRETMKSKIVDLNLKALKMGYNQAISGRPSAV
Function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Catalytic Activity: CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 21328 Sequence Length: 201 EC: 1.2.7.8
Q51698
MKTVLPSVPETVRLSRRGFLVQAGTITCSVAFGSVPAAAGDTAESTPSIAAVSPNVWVRVHADGIVDIVCPAVELGQGAHTALPRFVAEELDADWDRVRVQQAGASDKVYGNPLAWGTQFTAASRTTVGYFDVLRVAGAQARFVLVQTAARRWSVPADQLETQKGVVLHRRSRRSATYGELVASVQVPESFPHFFARNEATQPADDYFGAAPPSVVAQAAGPASGAIALKHRSTYRLIGKDAPRKDIPPKVNGQACYGMDVQVPGMLYAMVETGPVAGMAPERVDDGAARQVPGIHHVLSLPHGVAVVGRDIFAVRAARARLLVNWKANPDKQSYDSGQVLDEFSDLCRNGIERNAVQAWKQGELSSIDAVFARPDVRIESFEMQSDLVYQAPMEPQSAVIQPHADGSAEAWVGTQWPTVEQGFAAGILGIAPDKLTMHLPLVGGGFGRRLEPGALVDAAHIVRAIGKTVKVIWSREDDLKRNPFRQALACRVEAAVLEKDQRILALRHTVAADSWLARLFPQYFNAYQQTDPGNWIGGMVAYDVPLQRIDALTPRRSVDVCYMRGIGVAQVKFAQESLVDQIARRLNADPVDFRLAHLNTSPRGAAVVRTVAEMSDWKRRSADAGGGMALGLAYTPYSNAHVALVSEVHFNRSENTLSVSRVWCAVDVGMVAQPDIVKAQMEGGIIQGLSVALMERVQVAKGVLQHSNFHDYPMLRMSQVPQIHVRLVETDQAMAGVAELGLLQIGPAINNAFARITGQHLRSLPMRPALAQMKRSGPTA
Function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Catalytic Activity: A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one Sequence Mass (Da): 84483 Sequence Length: 781 EC: 1.3.99.16
O27881
MNYNIYVCGVGGQGIIKTSVIIGEAAMKKDINVVMSEIHGMAQRGGSVSTEIRIGEVHGSIIPDGEADLVLAFEPLEAIRALPKMSEESEVILNTSVIPPFNLMRSPHPYPPLDEIMSTLEERAGSVRGFNAEEIALKAGHILSLNMVMLGAAAATPGFPLESESLISSMRDNLPSRLIDVNLRAFRDGFGAAAES
Function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Catalytic Activity: CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 20948 Sequence Length: 196 EC: 1.2.7.8
P80911
MSYNIYVCGVGGQGIIKTSVIIGEAAMNEGMNVVMSEIHGMAQRGGAVSTEIRFGDVRGSIIPQGEADLVIAFEPLEALRALPKMSEDACVIVNTSKIPPFNLIKSPHPYPPLEEIIKTLEENAGRVRSFNGEKIAVEAGHILSLNMVMLGAAAATTGFPLGEETLIESMKNNLPPKLMEVNLRAFHEGFETVNCD
Function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Catalytic Activity: CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 21068 Sequence Length: 196 EC: 1.2.7.8
O07836
MKEYNIVITGVGGQGILTAANLLGWAALRAGYKVRVGEVHGMSQRFGSVIAYVRFGEDVYGAMVPEGKADVILSFEPVEALRYINYLKKGGLVFTNARPIPPVQVSMGLATYPTLDEMKKIVEEDFGGKFMAFDAEKLAMEAGNIVTTNVVLIGALSQTPGFPLSEEQIKEVIRISVPPKTIDVNMRAFELGVKAAKEMLGL
Function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Catalytic Activity: CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 21886 Sequence Length: 202 EC: 1.2.7.8
P23677
MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
Function: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Catalytic Activity: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) Sequence Mass (Da): 51009 Sequence Length: 461 Subcellular Location: Cytoplasm EC: 2.7.1.127
P27987
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILTEMSQDAPLA
Function: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Catalytic Activity: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) Sequence Mass (Da): 102376 Sequence Length: 946 Subcellular Location: Cytoplasm EC: 2.7.1.127
Q96DU7
MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQRPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAGLGPAPGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRSSLRTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQPEEASPWTQPGVHGPWTELETHGSQTQPERVKSWADNLWTHQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGPWTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQS
Function: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis . Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). Catalytic Activity: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) Sequence Mass (Da): 75207 Sequence Length: 683 Subcellular Location: Nucleus EC: 2.7.1.127
Q53932
MPVLMPSADVPTIDISPQLFGTDPTPRRTSRGRSTRPARGSGFFYASHHGIDVRRLQTWSNESTTMTDQRSTTWRSTRYNENNSHVRNGYYMARPGRETVESWCYLNPSFGEDHPMMKAGTPMHEVNVWPDEERHPDFGSFGEQYHREVSASRRCCCGASRWRRQAGESSSNEVTEEDTLSAVSMIRYPYLDPYPEAAIKTGPDGTRLSFEDHLDVSMITVLSKTEVQNLQVETVDGWQSLPTSGENFLINCGTYLGYLTNDYFPAPNHRVKYVNAERLSLPFFLHAGQNSVMKPFTRRTGDRKLNPAVTYGEYLQEGFTR
Function: Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin. Catalytic Activity: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N Sequence Mass (Da): 36577 Sequence Length: 321 Pathway: Antibiotic biosynthesis; penicillin G biosynthesis; penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3. EC: 1.21.3.1
Q8TMI3
MLDMTERQVESVLIEIPKGSRNKYEYDKEKKVIKFDRMLFSSMVYPCDYGFFPDTLALDGDPLDALVLTWEPTFPGCVIDVHPVALLDMKDDKGRDEKILCVPETDPLWNYIETLEQVPPHLLKEIVHFFETYKNLEGKHVIVIGWEGLDAAVDMLREAKSRYLEKNK
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 19525 Sequence Length: 168 Subcellular Location: Cytoplasm EC: 3.6.1.1
Q8PWY5
MTERQVECVLIEIPQGSRNKYEYDKERKVIRFDRMLFSSIVYPCDYGFFPDTLALDGDPLDAMVLMWEPTFPGCVIDVHPVAMLDMEDDKGRDEKILCVPQRDPLWNYIKTIEQVPPHLLKEITHFFETYKNLERKDVVVYGWRDLETARKVIQEAKDRYTEQKKLSNQ
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 20066 Sequence Length: 169 Subcellular Location: Cytoplasm EC: 3.6.1.1
P47593
MDKFLIDVIVEIPKNSKIKYEYDRQTGQIRVDRILFGSESYPQNYGFIKNTLDWDGDELDCFIFADQPFLPATVVPTRIVGALEMIDDGEIDTKLLGVIDCDPRYKEINQISDLPKHRIEEILIFLKTYKLLQKKTVIIKGLKDVCWAKKEYEICLQLMKDYGHLSKDQFIQKMQILHPEHYQK
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 21646 Sequence Length: 184 Subcellular Location: Cytoplasm EC: 3.6.1.1
O69540
MQFDVTIEIPKGQRNKYEVDHKTGRVRLDRYLYTPMAYPTDYGFIEDTLGEDGDPLDALVLLPEPLFPGVLVEARPVGMFRMVDEHGGDDKVLCVPVNDHRWDHIHGIIDVPTFELDAIKHFFVHYKDLEPGKFVKAADWVGRDEAEAEVQRSVERFKAGGH
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 18533 Sequence Length: 162 Subcellular Location: Cytoplasm EC: 3.6.1.1
Q98Q96
MSKIVVNIEIQKDSNIKYEYDRKRGKIVVDRILRGDFRYPANYGYLEDALDWDGDELDVLVYSQEKFLPGTSLNARIVGAMKMIDDGETDTKLIAVHDDDYRLENIKALEDLDSKWLEEIKYFFSNYKNWKRPGITKVSGFENTSWALKEYQECKDLMREYGHLPKKEFISKMMKMHPEKYEI
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 21715 Sequence Length: 183 Subcellular Location: Cytoplasm EC: 3.6.1.1
Q74MY6
MEVYAFIEVPKGSNVKYEYEDGKLKVDRILYGAMFYPYNYGFIPETLEEDGDPLDVLVITEEPLVPGSYIKVKPIGVLVTEDEKGVDRKIIAVPVKKVDPIYGEIEDISELKEGIKLKIKHFFERYKELEPGKFVKVKEFLGKEEAEKIIKQAQENYKKQ
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 18495 Sequence Length: 160 Subcellular Location: Cytoplasm EC: 3.6.1.1
Q9JVG3
MADFNQILTTGDVDGGIINVVNEIPAGSNHKIEWNRKLAAFQLDRVEPAIFAKPTNYGFIPQTLDEDGDELDVLLVTEQPLATGVFLEARVIGVMKFVDDGEVDDKIVCVPADDRNNGNAYKTLADLPQQLIKQIEFHFNHYKDLKKAGTTKVESWGDAEEAKKVIKESIERWNKQA
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 19799 Sequence Length: 177 Subcellular Location: Cytoplasm EC: 3.6.1.1
Q9K0G4
MADFNQILTPGDVDGGIINVVNEIPAGSNHKIEWNRKLAAFQLDRVEPAIFAKPTNYGFIPQTLDEDGDELDVLLVTEQPLATGVFLEARVIGVMKFVDDGEVDDKIVCVPADDRNNGNAYKTLSDLPQQLIKQIEFHFNHYKDLKKAGTTKVESWGDAEEAKKVIKESIERWNKQA
Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 19811 Sequence Length: 177 Subcellular Location: Cytoplasm EC: 3.6.1.1
Q6MVH7
MASQYSVRKVGAPYTLEHRVYIEKDGVPVSPFHDIPLYANAEQTILNMVVEIPRWTNAKQEISKEELLNPIKQDTKKGKLRFVRNCFPHKGYLWNYGAFPQTWEDPNSIHPETKAKGDNDPLDVCEIGELVGYTGQVKQVKVLGVMALLDEEETDWKVIVIDVNDPLAPKLNDVEDVERHLPGLIRATNEWFRIYKIPDGKPENQFAFTGECKNKTYAMDVVRECNEAWERLITGKTAPGGVSTTNVTVQHSSSRVAPDQLPPLPPNENLPPAPIDSSIDKWFFISGASA
Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 32639 Sequence Length: 290 Subcellular Location: Cytoplasm EC: 3.6.1.1
P80562
MDLSRIPAQPKPGVINILIEIAGGSQNKYEFDKDLEAFALDRVLYSSVKYPYDYGFVPNTLADDGDPLDGMVIIDEPTFPGCVIAARPIGFLEMIDGGDRDEKILAVPDKDPRYAHVKSLNDVAPHRLDEIAEFFRSYKNLEKKVTQILGWQDVDQVKALVDQSIKAYK
Cofactor: In the presence of Zn(2+), Mn(2+), Cu(2+), Fe(2+) or Co(2+) ions, activity is very low. In the absence of metal ions, there is no activity. Function: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Catalytic Activity: diphosphate + H2O = H(+) + 2 phosphate Sequence Mass (Da): 18961 Sequence Length: 169 Subcellular Location: Cytoplasm EC: 3.6.1.1
Q6DN90
MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYPQGPLVPGSSLSPDHYEHTSVGAYGLYSGPPGQQQRTRRPKLQHSTSILRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSVLCS
Function: Guanine nucleotide exchange factor for ARF1 and ARF6 . Guanine nucleotide exchange factor activity is enhanced by lipid binding . Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin . Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). Sequence Mass (Da): 108314 Sequence Length: 963 Domain: The PH domain mediates interaction with lipid membranes that contain phosphatidylinositol-4,5-bisphosphate, but does not bind membranes that lack phosphatidylinositol-4,5-bisphosphate. Subcellular Location: Cytoplasm
Q8R0S2
MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFQPPQPPVLCS
Function: Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (By similarity). Involved in neuronal development . In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). Sequence Mass (Da): 108015 Sequence Length: 961 Domain: The PH domain mediates interaction with lipid membranes that contain phosphatidylinositol-4,5-bisphosphate, but does not bind membranes that lack phosphatidylinositol-4,5-bisphosphate. Subcellular Location: Cytoplasm
O25008
MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANADFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSGTLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLVSVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAVRLRNISSSY
Function: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Catalytic Activity: [sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine Sequence Mass (Da): 42404 Sequence Length: 387 Pathway: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. Subcellular Location: Cytoplasm EC: 2.8.1.7
P57795
MAIHNCEGENVSTENKAVYMDNSATTPVRKEVVEAMLPYMTENFGNPSSIYEIGKTSKHAINLARKKAADALGAEENEIYFTSGGTESDNWAIKGIAFANRDKGKHIITSSIEHHAVLHTCAWLEGQGFEVTYLPVDKYGMVSPDELRNAIRDDTILISIMFANNEIGTIQPIKEIGEIAKENQIYFHTDAVQAIGHVPIDVKKLNIDLLSLSGHEFEGPKGCGALYIRKGVKIDPLLHGGAQERKRRAGTENVPGIVGLGKATELATAEIEESNRTLLKLRDRLIEGLLKIPKTHLNGHPTQRLANNVNVTFEYIEGESLLLLLNAKGIYASTGSACNSSSLEPSHVLTACGVPHEIIHGSLRLSLGRMNTSEDVDRVLEVVPEIVQKLRNMSPLTPKEYRTL
Function: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Catalytic Activity: [sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine Sequence Mass (Da): 44336 Sequence Length: 404 Pathway: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. Subcellular Location: Cytoplasm EC: 2.8.1.7
Q6GHV3
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMSEEVKKMFQKEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
Cofactor: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. Function: Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 33261 Sequence Length: 292 Subcellular Location: Cell membrane
Q2FZE5
MMIKNKKKLLFLCLLVILIATAYISFVTGTIKLSFNDLFTKFTTGSNEAVDSIIDLRLPRILIALMVGAMLAVSGALLQAALQNPLAEANIIGVSSGALIMRALCMLFIPQLYFYLPLLSFIGGLIPFLIIILLHSKFRFNAVSMILVGVALFVLLNGVLEILTQNPLMKIPQGLTMKIWSDVYILAVSALLGLILTLLLSPKLNLLNLDDIQARSIGFNIDRYRWLTGLLAVFLASATVAIVGQLAFLGIIVHVVRKLVGGNYRVLIPFSTVIGAWLLLVADLLGRVIQPPLEIPANAILMIVGGPMLIYLICQSQRNRI
Function: Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane (Probable). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 35078 Sequence Length: 321 Subcellular Location: Cell membrane
Q9TXD8
IVGGKTAKFGDYPWMVSIQQKNKKGTFDHICGGAIINVNWILTAAHCFDQPIVKSDYRAYVGLRSILHTKENTVQRLELSKIVLHPGYKPKKDPDDIALIKVAKPIVIGNYANGICVPKGVTNPEGNATVIGWGKISSGGKQVNTLQEVTIPIIPWKKCKEIYGDEFSEFEYSQITPYMICAGAEGKDSCQADSGGPLFQIDANGVATLIGTVANGADCGYKHYPGVYMKVSSYTNWMSKNMV
Function: Peptide isomerase that inverts the chirality at the Ser-81 of omega-Aga IVB. Acts cofactor-independently. PTM: N-linked glycan at Asn-127 consists of Man3-GlcNAc2-Fuc. Sequence Mass (Da): 26511 Sequence Length: 243 Subcellular Location: Secreted EC: 5.-.-.-
Q9RBP5
MSTVLVVGADKGIAHSISRQLHDRGEDVIAACLFDGADLAAAGITVEPGVDVTSQESVEALAARLSEKGVKLDAVFHVAGVMWLDEVGSLDYDLIRRQIEINTLGPLRTIEAVRPLLNEGAKVGIVTSRVGSLGDNTSGGMYSYRISKAAANMVGLNFHHDLSKDGVSVLLLHPGMVATDLTKDFPGEHSYITPEQAAAGLIKNIDNLTPETSGRFQHSDGTFLQW
Function: Involved in isoprene degradation . Catalyzes the two-step NAD(+)-dependent oxidation of 2-glutathionyl-2-methylbut-3-en-1-ol (HGMB) to 2-glutathionyl-2-methylbut-3-enoate (GMBA) . Catalytic Activity: 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH Sequence Mass (Da): 24062 Sequence Length: 226 EC: 1.1.1.398
Q9RBP4
MITVYGYVPAWGIPDISPYVTKVVNYLSFTGIEFEYKTQDLATLDQDSPHGKLPYIVDSDGTKVGDSNTIIEYLKNKFGDKLDADLSKQQLAQALAFHRLIEEHLYWSGIIQARWQDDAGWETYIPFIVQGAEVTPEMRVGLDAFRARILDGFNGQGMGRRSEEVVAEFFRADIDALSDFLDDKPFILGDKVHSIDASLYSTLRHIADQPQQWLGSGYVQTKPNLVDYLERIRKQYDI
Function: Involved in isoprene degradation . Catalyzes the glutathione-dependent ring opening of various epoxides . The highest conversion rate is observed with the physiological substrate, 3,4-epoxy-3-methyl-1-butene, which is the primary oxidation product of isoprene . It can also use other epoxides, including epoxyethane, epoxypropane, epithiopropane, epichlorohydrin, epifluorohydrin, epibromohydrin, 1,2-epoxybutane, 1,2-epoxyhexane, cis-2,3-epoxybutane, cis-1,2-dichloroepoxyethane and trans-1,2-dichloroepoxyethane . Catalytic Activity: 2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione Sequence Mass (Da): 27094 Sequence Length: 238 EC: 4.4.1.34
B1I0S9
MADTLAIVVAAGRSSRMGEGPKKQYRLLAGRPVLGRTLEVFEHAPAVDGVVLVVAPGEEDWCREEIVTRFGFTKVVAVVPGGEVRRDSVWAGLQALPPCALVLVHDGVRPFVTARQIAAVAEAARECGAATLAVPPKDTVKLGGPPGAPVSTLPRENLWLVQTPQAFRFDVLIKAHHLARERGLAATDDTSLAEAAGYDVRMVPGAYTNIKITTPEDLAFAEALLGGGPVLVGFGYDVHRLVDDRKLILGGVEVPHDRGLLGHSDADVLVHAVMDALLGAAGAGDIGRWFPDDDPTYRGISSMDLLVRVAAFLRERGLETSNLDAVVVAEAPRLSPFISRMRDNLASVLGVSPAAVNVKATTTEGLGFTGSGAGIAAYAVAALRRIVLPGDRVL
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 41482 Sequence Length: 394 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q6ARN9
MKNGAVIIPAAGSGTRMKLDYPKQYHAVAGTPIIVHTIRAFNKHPCIAKIILVVPQDHLEESKALLQKYQLENISIVTGGARRQDSVLRGLQEVPESIDIVLVHDGARPMVSAELISRCYKGAQQYGAVIAAVPVKDTLKRGAGRIVTGTVDREGLWQAQTPQAARKALLVKAFKENGMRNVTDESTLLEGVGIPVTLIEGSETNIKITRPEDLILAENFLREKKEPMQKIRIGHGFDAHQLVEKRRLILGGVEIPYHLGLAGHSDADVLVHALCDALLGAIGAGDIGRHFPDSSDAFKDIYSIRLLESVMQKVGELNYKIGNADISVICQAPKLAPYLKQMQEIIATSCACQISDINIKATTTEKMGYTGRGEGISCHAVVLLQQ
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 41971 Sequence Length: 386 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q72C30
MRTWVLLLAAGSGTRLATAGLPDAKQFLPLHGAPLYWASARTMAHVAGIEGIVFVFPPHRVEEERARISALDDGSVLGLDWHVVGGGAARQDSVACGLAALPRSCEAVLVHDAARPFASPALVARVLSALHDGHAGVVPGIPLTDTVKETTDGFVANTPDRSRLVAVQTPQGFTLKALSTAHETARTAGWNVTDDAALLERCGIPVRIVAGEVVNAKITTPEDLAMLDANEPQVTVPCVGWGYDVHRYGEGRPMKLGGVLIPEGPEVVAHSDGDVLLHALADALLGCIGAGDIGLHFPDSDAAFDNANSAMLLDRVLHMTHEARLRLTHVDLTIVAQVPKLSPWRDKIRANVARLLDLPVTSVNFKATTEEGLGFTGEKRGIKAIAAVTGLRPMP
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 41726 Sequence Length: 395 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q5FQD6
MRIAALLLAAGRGRRFDASSQSGENSSKQFRMLRGKPVIRRAAEALLPHVDVLLPVGDDPLLADSLEGLDILPPVSGGAERHDSVRNGLEALAKLPEPPDLVLVHDGARPCVPAEVVQNVINALKTHEGVIPAVAVIDTIKKAKDGIIVDTVPRDGLWRAQTPQGFRFGTLLELHRTHRDARTDDAALLEQAGHPVAIVEGSEDNIKLTVAEDLMRLEGVIDRNLLPRVGLGYDVHAFEEGRKLILCGIEVPHTKGLAGHSDADVGIHTLCDAIYGALAEGDIGRHFPPSDNKWKDMDSARFLVHAGERIRERGGFLVNADVTLICERPKIGPHAEAMRNRLADLLKVSVSRISVKATTSERLGFTGREEGIAATATVSIMVPDNGEA
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 41815 Sequence Length: 388 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q7VFU3
MVLDNVSLIMMAAGDSTRFCASNAQTFRCKKQWLRVGEEPLWLVATRNLTHHFSFKQVILTASSKDYVYMQNISPYKVVQGGQTRCQSLRNALKYVDTPLVLVSDVARWDSSDSIIKTMLKALDESVACVVPFVGVADTSFYEGEYLKRESIKLIQTPQLSRVEDLQEALKDTSKDFSDESSALYALGKKIAFVQGSELMNKLTFSSDLKAHITRLSPPSKRVFIGNGIDVHQFEKNKQMWLGGVEIESPFGFKAHSDGDVVLHALSDAILGAIGGGDIGEWFPDTDETYKNADSKMMLSEIYTFAQSVGYELYNADISIIAQTPKIAPYKSAMRECIARILRVPNAHINIKATTTEGLGFVGREEGVCVEACVSMGFINWHTYIKDLH
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 43300 Sequence Length: 389 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
O25664
MSLIRVNGEAFKLSLESLEEDPFETKETLETLIKQTSVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRHYPEIKLVKGGASRQESVRNALKIIDSAYTLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREAIKLIQTPQLSHTKALQSALNQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLFFNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 45529 Sequence Length: 406 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q0C0N0
MTETVAIIVAGGRGQRAGAERPKQWQMLLGKRVIDWSIAAFVDHPQISQVVIVAGDELGDCSAEPKIIQAKPGNTRTQSVLSGLAAATISEDATVVIHDAARPGIDAATISSLIARLQDPSVSGAAPAMPVADALKTNSGQSWTNVDRTGLVRVQTPQAFRLGEIRAALSAAGPDLVDDLTAIEAAGGRVEIVSGSARLTKITYPEDFDMLARLLSPTGAPRIGKGYDVHEFEAGDHVTLCGVAIPHIAKLKGHSDADAAWHALTDAILGAVALGDIGDHFPPSDPQWKGADSGLFLKEAQRLAEAKGYVIANCDITVICEAPKVKPHREAMRARTAELLGLPLDAVSVKATTTEGLGFTGRREGIAAEAVALLMPKG
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 39494 Sequence Length: 378 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q28Q60
MEKPAQRATAIIVAAGRGIRAGGGEPKQWRRIAGRSIVEWSVNRFAAHHAGFDVVLVIHPDDEWRLNGLDLPTTLRVVHGGDSRAASVKAGLAVCCDAGHVLIHDVARPCVSLAVIQSVLDATRAGGAAAPALPVTDALWRGDTHVSGTQNRDGLWRAQTPQGFDVSAIRAAHAAHDGTAADDVEVARLAGIDVAIVPGDEANLKITGPEDFARAEALLTGGDMDIRVGNGFDVHRFGPGDQVWLCGISVPHTRGLQGHSDADVGLHTLTDAIYGALAEGDIGTHFPPSDPQWKDAESHIFLTHAVELAANRGFSITNADLTLICEQPKIGPVASAMRARVADLLRIDVARVSVKATTSERLGFTGREEGIAALATITLVAR
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 40213 Sequence Length: 382 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q6ADI0
MCTASRPRIAVIVVAAGSGTRLGAGSPKAFVTLGGRTLLERSLHAVRCMREPAQVVVVAPEERLAEAAALGEAGFGAAVDVVAGGETRQGSVAAGLGALREGVEIVLVHDAARALTPAAQFDAVVAAVDAGGAGVVPGLPVSDTIKRVGADGEVRETVDRSVLSAVQTPQGFPRDQLVAAYAAATTDETDDAELAAAAGHPVTVIPGDARAFKITTPWDLRRAEELLAGLAAPRIGFGTDTHAFDPSAELWLAGLRWEGEPGLAGHSDGDVVAHAIVDALLSAARLGDIGGVFGTGDPRFSGAHGEVFLTETRRLVEEEGFRIGNVSAQIVGNRPKFAPRRAEAETLLSRVLGAPVSVSATTTDGLGLTGRGEGVAVFATALLLAP
Function: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 39296 Sequence Length: 386 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Q472F2
MSDRRFALIPCAGTGSRAGGSVPKQYQPVAGRPMIWYALAAFSACDAISATALVLAPDDMPLESRFGADIFAGLRFDTAFVGGDTRHASVLAGLHHLAQLGATDTDWVLVHDAARPGLTPAMIHNLVRAVESDNDDDPDAAIGGILAVPVPDTLKRADAGERIGTTVPRDGLWQAQTPQMFRVGVLRQALQDALAAGAVVTDEASAIERLGLHPRLVNGSLRNFKVTYPEDFALAEVLLGTGPARSADSGA
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 26331 Sequence Length: 251 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q6AAV8
MPTMVDEHTPPVVAVVVAAGLGTRFGGPVPKQVTSLTGKAVVAVAVESLAAGGCDEAVVVVKEGMHNHLQLALAASPIPVHFVTGGNTRQESVRNGLRFIAQHHRLSDATTVLIHDAVRPLVPAYVVENVIAAVENGAVAVTPVVDVVDTIRQVDGDTSSVVDRSTLRAVQTPQGFKRDIITECHEQLSIEGGSVTDDISCCERYGHHATFVEGSRMSLKITEPVDLDVAEVFAKAAAGAGRHSGRRIGRMLHAVKPSTVARKLGRGSRR
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 28502 Sequence Length: 270 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
A0JPF9
MGTVTIQLSCLRHIRKLCFSCPWEGRRLFKMLLQFHHETQRPLDPGCLLPQDAERSADQPGRAVVDFPVAAVLPAGGSGERMGLTTPKQFCSIFNRPLISYTIQAFERLPWIVMVVVVVAKDNHDLMLNIVRKFNHTKVKVVHGGTTRHRSIYNGLQAFSDSTDSSTPKPKVVIIHDAVRPFVEEDLLLKITLAAKEQGASGAIRPLVSTVIATTSESYLDHSLERAKYRASEMPQGFLYDIIFQAYQRCSEFDLEFGTECLHLALQYCGTNARLIEGPPTLWKVTYKRDLAAAEAIIKETLSVSACIIAEAEEEAVELAKTLQKNLNMMETDVIPCGKESNVQYLSKTRNFIHISASASSSLWVLEMVKCFEDIDHARLYPVVIVWVQLSMTKQSADSQETDEFMALASEVKQRNVLLYGIKIDHSKELEQWQRSLERLGQITLVLIRDRNMALTGQMLHV
Function: Cytidylyltransferase required for protein O-linked mannosylation . Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity). Catalytic Activity: CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate Sequence Mass (Da): 52064 Sequence Length: 462 Pathway: Protein modification; protein glycosylation. Subcellular Location: Cytoplasm EC: 2.7.7.40
Q47EL2
MPRHYAIVPAAGSGSRFGAEKPKQYLDLLGRPLIFHTLAALTASPDIERVWVVLAPDDPWWPRYDWSELGSKLETVRCGGATRAESVSNGLRAAAMVAADDDWVLVHDAARPCLSAAMLDALFAELASDPVGGILAVPVADTLKRADAEQRVGATEPRDGLWQAQTPQMFRYGLLGEALEKCRDVTDEAGAIEAVGLKPKLVRGDSTNLKVTYPADLALAAMILRARK
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 24573 Sequence Length: 228 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q3ZAD7
MFLNEKVGAVIVAAGQSRRMGGQDKIFARLSGKPVLAHTLSVFQQSPEIDDIALVVSEHNLKKAKELVKEYNFSKVIAICSGGELRQDSVSSGLTALCDCGWVLIHDGARPLLDPVSIPEGLEAAKLCGSAVAAVPLKDTVKEISPEGLVEKTLPREKLISVQTPQVFRADIIQKAYRRVGITATDDAQLVEKLKLPVKIFSGAYANIKITTPEDLLMAEILLKKGR
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 24556 Sequence Length: 227 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q9RR90
MSAPHTSSPRTAALIPAAGSGTRLGLGPKAFVEVAGRSLLARSVAALAPFVDEVVVALPAGMDLPAGVPARAIVGGETRQGSVRRLLEATEAGTVLIHDAARPFVPPPVILALLDAIAATGAATVALPVADTLVRAEGQSWGQLVPREGLWAVQTPQGFRRELLLQAHARAEAEQYAATDDAGLLARLGVQVRLVPGDARLFKVTTPGDLALAEALTGHVDGGWLTVEGEKR
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 23895 Sequence Length: 232 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
A4J0Y3
MGNIVAVIPAAGMGSRMGTEVKKQYLKLQDRPILAHTIDALEQVPDITGIVLVVSPGEETLCQELILKGNLFNKIMAVVPGGDHRQTSVYHGLCSLPGDTELVVIHDGARPLVQRAEISHIIKEARRVGAAALAVPVKDTVKLVNDQGYVIATPNREKLWAVQTPQVFNYELILKAHQDAREKGVYATDDCALVEALGQPVKLVQGSYENIKITTPEDMVMAQAFLKRRNCWCE
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 25658 Sequence Length: 234 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
B5YF77
MEKIVGIVVAAGKSKRFGEDKLLINIKGMPIVYYSIRKLHDIKDIEKIILVVRNEMLEYYKEKIKDWKLEKVYKLVLGGEERQDSVYNALKSVDFHCDYVLIHDAARPFVSIKKIEELIKFCTENSLSAILGIPVKDTIKVVDNTTKRIMETLDRSKLWIIQTPQMFPFEIIKEAHKKAREENFVGTDDASLVERLGIPVYVIEGEPFNIKITTKDDLLWMEGILSKSELV
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 26688 Sequence Length: 231 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q8X7Y4
MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVYALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGAAITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 25733 Sequence Length: 236 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q3ALY8
MHLLIAAAGSGRRMGADRNKLLLPLAGRPVIAWTIEAALRSERIEWIGIVGQEVDREAILAVLDEPSKPVHWIQGGSTRQESVLCGLAGLPEQARHVLIHDGARCLAEPKLFDRCAAVVEDGTALIAATPVSDTIKRVGSDGVIRDTPDRSELWAAQTPQGFAVDQLRRGHAEAVAQGWTVTDDASLYERLGWPVQVLDAGPANIKVTTPFDLTVAEAVLALRSAG
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 24200 Sequence Length: 226 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
P74323
MHLLIPAAGSGKRMGSGHNKLLLNVLGQPLLSWTVQAALASQSIEWIGIMGQPYDFPAFEALLTPLHSPKPVQLIVGGDTRQQSVFNGIQALPPGAKFVLIHDGARCLATPDLFDRCTEALQHCQGLIAAMPVKDTIKIVNADGWITDTPDRQGLWGAQTPQGFDVALLKACHDKGKQEGWEVTDDAALLEKCGQPVKIVPGEDTNLKITTPVDLAIAEFILGQRSAKSA
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 24643 Sequence Length: 230 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q47LV0
MSLDQPAHRRPRVAAAVLAGGVGSRMGSAHPKQLLRLAGQTILERSVAALCAAPEVDEVVVVMNAAHLAEAEKILAEGRYDKVSRIVPGGASRSESSLAALQAVDDYDDNDLLLLHDAARPLVSGRTITACVTELTEVGAVGVAVPSSDTVVQVTLDASGREVIAAVPDRAALRRMQTPQGFRLGVIRRAYARAFAEPGFTATDDCGVVLRYLPEEPVRIVTGEESNIKVTHPSDLAVAEALLRTGVAQ
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 26230 Sequence Length: 249 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
A6LPA6
MNVAVILFGGKGERFSKDYPKQFVKFHGKTLMEHTVEKFLENFIHLIIIVVNGEYLEESKKILKKYKRKNIYVILGGKTREFSTLNAVKYLKDLISEDDNVIIHDGARPFVSKEVILRNIDFVNKYGAVVTAVPVENTIAFVENKIVKEIPPRRYLFTLQTPQTFKYSILYKSFRLIKDLEKFTDDSSVVLAAGYNVHVVYGEKTNIKITTKEDLYLIGVEKIEGNI
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 26161 Sequence Length: 227 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q9X1B3
MNVAILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVVEKRVFHEKVLGIVEGGDTRSQSVRSALEFLEKFSPSYVLVHDSARPFLRKKHVSEVLRRARETGAATLALKNSDALVRVENDRIEYIPRKGVYRILTPQAFSYEILKKAHENGGEWADDTEPVQKLGVKIALVEGDPLCFKVTFKEDLELARIIAREWERIP
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 25370 Sequence Length: 222 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q72GN3
MEVSVLIPAAGNGLRLGRGPKAFLQVGGRTLLEWTLAAFRDAAEVLVALPPGAEPPKGLGAVFLEGGATRQASVARLLEAASLPLVLVHDVARPFVSRGLVARVLEAAQRSGAAVPVLPVPDTLMAPEGEAYGRVVPREAFRLVQTPQGFFTALLREAHAYARRKGLEASDDAQLVQALGYPVALVEGEATAFKITHPQDLVLAEALARVWSA
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 22423 Sequence Length: 213 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q3SK38
MKFYALIPAAGSGSRMGGAIEKQYMDVNSVPMIAHAMMVLAREPRIARIFVVLSPTDKRWNNYEWQGWEERIEVLRCGGGTRAETVLNALDAIAEVCDPADWVLVHDAARPCLPDEMLGKLLDEVADDPVGGLLAVPVADTLKRAAGDTSSGTRVEATVPRAGLWQAQTPQMFRHGTLTEALRAAGSDMTDEASAIEKLGLQPQLVESDSRNLKVTYPQDLELASLILGKMNA
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 25286 Sequence Length: 233 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
A5CW51
MSNDYYLIIPAGGIGTRMHSEKDNINRKIKIAKQYLKLDNGLTILDQTLKILLNIDQIKGCIIALANKDYLFTKSKFNNHSKLITTVIGGKKRMNSVFNGLKALTNLAKDDDWILVHDSVRPCVKASEIINLMNQLKHHETGGLLATKVVDTIKQASNNIVNTTIDRSNLWQAQTPQMYRFGVLLKALNTVINDGMNITDEASAIEYLRLKSVLVKSSKSNIKITNSEDLELANFYLTQYKE
Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Catalytic Activity: 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate Sequence Mass (Da): 27242 Sequence Length: 242 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. EC: 2.7.7.60
Q181G8
MDFIRLKSRAKINLSIDVLGKRQDGYHFVEMIMQTIDLYDIVKIKELDEDEIKVKSTSLDIPLDEDNIVYKAAKILKNKFYIKKGVEIFIEKNIPVAAGMAGGSSNAAAVLVGLNHLWELRLSEDELKEIGLNLGADVPFCISGRPALAQGIGEKLTNIKGLPCDTNILICKPDLFVSTKEVYQGLDLNNIKKRPNNKYLIECLKSEDIKAVSESMVNILENVTIGKHKEISDIKQVMMKNNALGSMMSGSGPTVFGLFKNKEDALIGKKELLKKYKQVYVVNSSQKGVEICGEFN
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 32943 Sequence Length: 296 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
Q8XIA9
MKMKAYAKINIALDAIGKREDNYHLLRMIMQTVDLYDVIDIEKSNDSNISISCNKHYVSTDERNLAYKAAVLFRDEFNIKDGVKINIKKNIPVAAGMAGGSTNAAAVLVIMNKLFNVNASLEVLKEIGLKIGADVPYCIEGGTALCEGIGEIITPLKPFENKILVVLKPNFGVSTKEVYTNLDINKIRKHVNIEGLIQAMENDDLDYVSKNMKNVLENVTLKKHTILKNIKEDMRKSGALGAMMSGSGPTVFAFFDDMLTAQRAFEFLKGKYKYSDVYITRTINSNNL
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 32086 Sequence Length: 288 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
Q8FQZ4
MRITARAWGKINLHLGVGPAREDGYHELVTVFQTIDLAETITLTTLEDELVEEGSVVRQLTVTGPRGVPTTPDNLAWRAVDALVGRRREHDRTPLPAVELHIDKGIPVAGGMAGGSADAAAALRAVDAWIGPFGEETLLEVAAELGSDVPFCLLGGTKLGTGRGEQLVDMLSRGTYHWALVVSPKGLSTPEVFAKFDEMSLPSSMDVTPMSQALLDGSAGALAEVLENDLAPAALSLRPDLRKTQLAGLRAGALATMVSGSGPTIALLCDDAQSARDVADALMDEGVGLSVHPATSPVPGPAKNRGAHIVSIESE
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 32871 Sequence Length: 315 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
Q8NRY0
MKITAKAWAKTNLHLGVGPAHDDGFHELMTVFQTIDLFDTVTLTTLDEELVEEGSVVKQLSVTGARGVPEDASNLAWRAVDALVKRRAEKTPLSAVSLHISKGIPVAGGMAGGSADAAATLRAVDAWIGPFGEDTLLEVAAELGSDVPFCLLGGTMRGTGRGEQLVDMLTRGKLHWVVAAMAHGLSTPEVFKKHDELNPESHMDISDLSAALLTGNTAEVGQWLHNDLTSAALSLRPELRSVLQEGIRSGAHAGIVSGSGPTTVFLCESEHKAQDVKEALIDAGQVYAAYTATGPAASTADQRGAHILTVS
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 32630 Sequence Length: 311 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
Q4JU24
MSISHIFGPQQPQYSSVTASAHGKVNLHLGVGPAREDGYHELDTIFQAVSLKEEVTVALRDARGAQDAEAVQVAEAAQEAADAAPCTWSVSGFDSHLVPQDSSNLAWKAVAAIQKLARQAHVPWADAPVHIHIDKGIPVAGGMAGGSADAAAALVAATELYFPDSRASRRPDGAQLSDIAAELGADVPFCLLGGTARGTGKGENLMPVIATGTYHWAIATDKRGLSTPEVFKQLDQQRAAASAASPKAARAGSPEGLIAALRTGNPEEVGKLLVNDLQAPAISLLPSLRETLKAAEEAGAIAAIVSGSGPTVAMLCASADDAVEVATAVSVAGKASSTMTTSSPAAAAGVIKREEVLE
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 36500 Sequence Length: 358 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
Q2YBH5
MNGILSTTEVDSQAELSCPAPAKLNLFLHVVGRREDGYHLLQTVFRLVDFADQLHFGLRADGVIKLHTPTPGVPEEQDLCVRAAKLLQRESGTPWGANIFLEKRIPMGGGLGGGSSDAATTLLALNRLWKLGWRRNQLLKLAPELGADVPVFVFSENAFAEGIGEKLLPIALPPAWYLILTPPVHVSTAKVFSSKELTRNTIPIKIPPFSTEQGHNDLEPVVCASYPEVARHLEWLRQLEGARMAAMTGSGACVFAEFATESGARSALGKIPYGMKGFVAQGLDRHPLHDFAEQ
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 32008 Sequence Length: 294 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
A1SNG8
MRAPAKVNLHLGVGAPREDGFHPLVTVYQAVGLYDDVTARAAPDWSVGVGLPDWMDDDAVPLNGANIVDRAADLLAAHHGVERTGELHIAKAIPVAGGMAGGSADAAAALVALDRLWGLDTSDDDLLALAARLGSDVPFALLGGTALGTGRGEVVTPVQDRGTWWWVVVPSDTGLSTPEVYRHFDRMFPDAPSQPVPADALLGAIAAGDTWALADALHNDLEAAAIDLRPELGRLIERGEEAGALRGLVSGSGPTCVFLCGSADHARSLAADLSGAGHPVVLAANGPVAGAHLVSYA
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 30448 Sequence Length: 297 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
Q30ZH4
MLTVPQQTIRSGCKINLFLEITGVRPDGYHELVTLFYPLSEPFDLMEISPATHGVTVLSERADLCGDKNIICKAWHTFAAAGGTPPPMQVRLAKGVPDGAGLGGGSANAAAVLKLLNTAGGAPRFSDTALAKIAAQVGADVPFFLHNTPCLATGIGEKLVPAPLDLSGWHLVLVCPGVQVSTPWAYNRWDTLYRSGLHHPCGQLPAAHAPAACAQLQTTGPDRPVRAETGCAGRKKNTCRSLTTERQADSKPVSRALWLFNSFETVVFSAYSELRQHKNTLLAHGASAALMSGSGSSLFGLFRDKAQAEAAMLHFCQRSIAVYVHRL
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 34850 Sequence Length: 327 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
A1AZ43
MPLHRREAAPAKLNLTLHVTGRRVDGYHLLDSLVVFLDLGDVVTIAPGPLSLSLTGPFAPGLAAEPDNLCLRAARLAGREARITLEKNLPVASGIGGGSADAAAVLRALDASPRRPEALGADVPVCLASRPVRMRGVGEILAPLPALPELNVLLVNPGRGLSTPAVFKALARHDNPPMPEPLPDFPDAQALIGFLHECRNDLEAPAIALMPGIADCLAALRSAGAQLARMSGSGATCFGLFASAAEAQAARARIAGTNPGWWVAASGLAPAKH
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 28146 Sequence Length: 273 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148
Q7U7D2
MGTITVTAPAKVNLHLEVLGIRSDGFHELAMVMQSIDLADRLSFQTTADAALTLSCDDPSLSLGEDNLVIRAAQLLRSRSGFNELGAAIHLEKRIPIGAGLAGGSSDGAAALVGLNALWGLGHSRSDLQRFAAELGSDMPFCVAGGSQLCFGRGELLEPLPAVQESLAVLLVKDPRVSVSTPWAYRRCRELQGDRYLSGEDAFEQRRQVLRDMAWTQPIRAAEPPPLQNDLQEVVEPETPAVQAALRLLSTLEGTLAVAMSGSGPSCFALFADPTSCAAAQATLEQQLAAEGLQSWCCNLRPDGVRIEA
Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Catalytic Activity: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) Sequence Mass (Da): 32875 Sequence Length: 309 Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. EC: 2.7.1.148