ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
P61035
MPGFNAVPRRDYVMAALSGVLLALSFPKPGFSILAWVALVPLLLACGRKAPAVAFRLGFTAGLVAYAGILYWINIAVVTYGRLHWSVSIVIFLMLAGYLALYPAATAYVVRRGEDRGISALLAFPVVWVGLEYIRSFLLTGFPWASLGYSQYRTLPLIQIADLTGVYGLSFLIALSNVVLYRIIRGFAARERAPYPVKSAAILVLLLVATLAYGFNRLHRPEAGAPFSVALIQGNIDQSVKWDPAFQEATVAVYERLSRKACSTGPADLVVWPESAVPFYLQNEEKYASRIRNLTRELRSCTVVGSPAFERDGETIRYLNSAFLLSPWGDVVGRSDKIHLVPFGEYVPMAKFLPFVNKIVAGIGDFSPGARIASLETGKGAIGVLVCFEGIFPELARGYVRAGSRVLVNITNDAWYKRSSAPYQHLSMTVFRAVENRVPLVRAANTGITAIIDSKGHILRMTNLFEVWRPRFSWTRK
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 52609 Sequence Length: 477 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q7NJV1
MSGIALRRRREQAQRRRSIAGVLAAVGGGTALGLAAPPTGWGVLVWVALVPLLVYLRAEHRPRAFWLGTLAGMVYYAILLRWLLGFHPLTWLGIEWWPSLAIALGAWLFVSASQAWVIGLWASLVVRTRLSGLRRVLFAVGLWVGLHWLWGQGETAFPWGTLAQSLAGDLWAVQTVALGGAQLLVGLAVAVNALVAESWSTRRVGYAGLAALLAASVYLYGWWQLAQPLPAGEPLRMGVIQGNIAQARKWTPDGRRETVETYVRGYEELAAAGAQLVLTPETAFPFIWSRPTNPAAPLVPEIQSRRVPVLLSAFERRTDGQVATTLFALDGDARTISTFNKIHLVPFGEQIPLKALIGPLVRKLSPVQQEVFAGSLGQRLQTPVGLVAAGICFDSAFADGFRAQVAAGARLLVQSTNDAWYGPAMAPQHHALDALRAVETGRYLVRASNNGTSAVVDPLGRTTRITGWNVYAAFVEPVRLLEGMTLYALWGDWFVPLSAALALLGLIAGRSPAGRRGRRNF
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56431 Sequence Length: 521 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q7VM56
MNLVNPSILVACILSFCLGAIGCLAFSPFDIWLIAYLSAAGLIWAATLVERKTAMLATFAWSIGYFGVGVQWVNVSMTQFGGVPVIVSYLAVLLLASYLGLYNLLFSYLARRFGLISPFVLASLFTFTEYLRGVVFTGFPWLQFGYTQIDSPFAQLAPIFGVEGLTFLVILLSSYLVDIVKNPTRKIATFTKIAVIIGFSLASNLLQFVQIDQQKPPVKVALIQANIEQQLKWDPAHFENTLRTYQQLINSSLAENEVIILPESAIPALESKINPLLNQLQKMAAAKNTEIIIGTLYENEQQQLFNSALVLGNQTKPYQLHQSLRYNKHHLVPFGEYVPFGSLLDWMREVFILPVNLAKGPFIQPALFTNKGKFNMAICYEVIFGHQLQQNQLAQQADYLITITNDAWFGDSIGPWQHLQMARMRALELGKPLLRAANTGITAVVGFDGKVIKKLPQFETNTLTAEIATTKGHTLFGQFGHWLIYSLSFICVAFGLFRRQKHKKH
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56529 Sequence Length: 505 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
P44626
MKNLNRILLSIKFMNKYFTYLIAIISGLLGVFAFSPFDYWPLAYVSLLGLLYVAKNPKKSTALLSTFLWAMGFFCFGVSWLNVSIHQFGGASLGVSYFLVGLLAAYLALYPMLFTYLVHHFKVQSAVIFAVIWTLTEFLRGWIFTGFPWLQFGYTQIDSPFYGIAPIFGVTGLTFFTVWASAVIFNLVSSLFKTKNLKLVLANALLLIIVGGLSAYSSRIHFVKSVEDKAISVTLAQGNIEQNLKWDPNYFYSTLAIYQKLITENLGKTDLIILPESALPTLENAITPFFEGLERAAKETKTEIMVGTVFQDTKSGKLLNSIMTAGNPDFPYQPNTQNRYNKHHLVPFGEYVPLESILRPLNSVFNLPMSAFQSGEAVQPSLIAKKRAFSPAICYEIIFGEQVRQNLKQDTDYLLTLSNDAWFGDSIGPWQHLQMARMRALELGKPLIRATNTGISVFVDAQGKVLAQAPQFIETTLTYKIAPAEGKTPYSVLGNMPLYALSLLFLLLHSMMAFIRRKMNIL
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 58553 Sequence Length: 522 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q7VFP7
MLPFYAQWVLESYDKAISPLLVSLLGLFSIASVLFVPKNRRFGVGFFIGMLWFYWISLGLRYFDMSFLIPLVVIACGIFMGFVFYIGLWCECLIVRFAFLLLLSYLTPFGFDWIVPESVFAYSYIGVDKLSFALSILALWILFKYKTWWKLGGVICLVFALDFGLKDSKIQNLPPLKIKLAQSAVSQDFDYRMREAKSIFSEHISDIQKAINEEYDVIILPESAFYVPLDSQYFPYFDSLLEMSHKIVIIVGALREEIHTDGRASYFNSTYKFDKGKVSFYDKVHLVPFGETLPSFLLPLVNTFFQGIGGFSAGKDFGYFDIAEIKFKNAICYEGSNRGFYADYPQYVIVTSNNAWFVPSIEPILQKNLMKYYARLYGSVIFHATNLSPAAIITPFVSSR
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 45856 Sequence Length: 400 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
O24982
MRLLLFNQNAFLLACMFVSSVYVNAVLDAYAIENPYISITLTSLLAPLSMLAFLKTPRNSAFALGFFVGALLFYWCALSFRYSDFTYLLPLIIVLIALVYGVLFYLLLYFENPYFRLLSFLGSSFIHPFGFDWLVPDSFFSYSVFRVDKLSLGLVFLACIFLSTKPLKKYRIIGVLLLLGALDFNGFKTSDLKKVGNIELVSTKTPQDLKFDSSYLNDIENNILKEIKLAQSKQKTLIVFPETAYPIALENSPFKAKLEDLSDNIAILIGTLRTQGYNLYNSSFLFSKESVQIADKVILAPFGETMPLPEFLQKPLEKLFFGESTYLYRNAPHFSDFTLDDFTFRPLICYEGTSKPAYSNSPSKIFIVMSNNAWFSPSIEPTLQRTLLKYYARRYDKIILHSANFSTSYILSPSLLGDILFRKRS
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 48474 Sequence Length: 425 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q608N5
MKAMLLALTGGILLPFAFAPFGYALVAPLSLALLFRVWLNASPSKAALYGYLFGLGQFGIGVSWVFVSMYEYGGSDVFSAAGLTALFVAYLALFPALAGWLGVKAGGGSILVRTLLVFPAAWVVTEWLRGWLFSGFPWLQIGYSQTDTGLRSIAPVFGVFGVGWLLAVLAGLLLSAWLLDRRGRRFALLGAAVVLVGSTQFAKVQWTHPAGDPIRVTLLQGNVPQDQKWRPEAKTTTVQMYVDMTRQHWDSRLIIWPETAVPAFYQQVAESFLAPLEAEARQHGVDVLVGVPYYEAQGNRYYNALVTLGAKPGRYFKRHLVPFGEFLPLRPVLAFVLDILQIPLADFTAGAHRQTLLQAAGYPLIASICYEDIFGQESLTGLPEGAYLVNVTNDAWFGDSFAPHQHWQKARMRALETGRYMLRATNTGVTGIIDAGGRPVAVAPMFEREALTGMMQPMAGATPYALWGDWPAIGLCAGIVGICFARRRRNASSHQGRQAEPGRN
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55064 Sequence Length: 504 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
A0QZ13
MIPAVTDDDPLEDPLDDDVAPGLDDAEPEPEPRDEHDEPSRPATGSRIGGWVARRGSRFGKGVLDRCAPLSAAIGGGLALWLSFPPIGWWFTAFPGLALLGWVLTRTATTKAGGFGYGVLFGLAFYVPLLPWISGLVGAVPWLALAFAESLFCGLFGLGAVVVVRLPGWPLWFATLWVAAEWAKSTFPFGGFPWGASSYGQTNGPLLALARIGGAPLVSFAVALIGFSLTLLTAQIVWWWRHGHKPGVPAPAVMLPGVAIAASLLVTALVWPQVRQSGTGAGDDTAVTVAAVQGNVPRLGLEFNAQRRAVLDNHVKETLRLADDVKAGRAAQPMFVIWPENSSDIDPLLNADASAQITTAAEAIDAPILVGGVVRADGYTPDNPVANNTVIVWEPTDGPGERHDKQIVQPFGEYLPWRGFFKHLSSYADRAGYFVPGTGTGVVHAAGVPIGITTCWEVIFDRAARESVLNGAQVLAVPSNNATFDEAMSAQQLAFGKLRAVEHDRYVVVAGTTGISAVIAPDGHEISRTEWFQPAYLDNQIRLKTDLTPATKWGPIVQAVLVIAGVAVLLIAILHNGRFAPRMLRRRSATTVKR
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Can transfer a number of fatty acids (C16 and C19, palmitic and probably tuberculostearic acids respectively are shown) . Enhances the polyprenol monophosphomannose (PPM) synthase activity of Ppm1 (AC A0QZ12) without itself having PPM synthase catalytic activity . Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 63346 Sequence Length: 594 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell membrane EC: 2.3.1.269
Q9K0A2
MVSKLDKYWQHPALYWPLLILFAAATPFTFAPYYHFWLMPLIFGAFVRLIELRPRFAVSSAYLFGLTAYTTQFYWIHTALHDVSGLPDLYAVPLTFLLPAYLALYPALCFWLWKKFTLPRGIKIGLVLPILWTLTEFARERFLTGFGWGAIGYSQITPDSPLAGFAPLGGIHMVTLATAFLGVWLVLASNNTARSGKRLLPIILIAALLAAGYTARQTDFTRPDGSRSTVALLQGNIDQTLKWREDQVIPTIQKYYEQVGKTTADIVILPETAIPVMRQNLPENILAKFAEQAQNNGSALAVGISQYTSDGNGYENAVINLTGYQENNQDGIPYYAKNHLVPFGEYKPLPFLTTPLYKMMDMPLSDFRKGGGKQSALLMKNQKIAFNICYEDGFGDELIAAAKDATLLANASNMAWYGKSNAMYQHLQQSQARAMELGRYMVRATNTGATAIISPKGNIIAQAQPDTETVLEGHIKGYVGETPYMKTGSSWWLMGILALAALILFIFRNKEH
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 57062 Sequence Length: 512 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q820C9
MNGYFRLIAAFALGVATVSGFAPFYLYPIPVVTLALLALLWRRSRTPGQAALTGFTFGMGLFGAGVTWLYVSLHDFGHMEPALAVLALIILCAYLALFPALTGWITAFRHFRASWAWPGMVAALWALAEWLRGTLFTGFPWLTVGYSQAPASPLAGFAPVIGVYGLSLLLMLSAAWLACWLENRQSHRFWLGLGSVWLIGFGLQQIHWTQPEGEPVTVSLLQGNIPQNMKWQPEHLAATMQIYAELVQESPSRLIVTPEISFPLFYEQAPQDYLALLAEHARSRQGDLLIGMAERSSSDNGYYNTMFSFGTSPEQSYRKYHLVPFGEYIPLKPVFGWIIDVLHIPLSDFSRGGLDQQPLDLAGQQVAVNICYEDVFGEEIIMQLPQASLLVNVSNDAWFGRSIGPRQHLQISQMRALETGRYMLRATNTGVTAIIDERGRVLEQLDMFTTAGLHSTAQGFGGATPYVRFGNSLVFALIGLLLLAGSLAAFSGRRKTL
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 54905 Sequence Length: 497 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q8YYI9
MGLTVAPFAAWFLAWIALAPLWIFVVSSKRKNYPPSSLLLLGLTWGIGYHGVALFWITGIHPMDWLGVPWWPSLAITIFCWSFISFYGGLFGAIWAACLTHISEQKSWLRILIGTAMWCVLESLWSAGPLWWSSLAYTQSPHNLAILHLGQISGPNLVTAAIVSVNGIVAEAWLNRKQGLLGRYLAIATGLLITLHLIGFGLYTAPIAKSSDTALKVGIVQGNIPNKIKLLPQGLSRAITGYTDGYLTLVNQGVEAVLTPEGALPFFQRNLPTTPLVSAVREKGVVAWIGAFGDRGRSYTNSLFTVNSQGEITSRYDKSKLVPLGEYIPFEGIIGGLVQRLSPLDEHQVHGSPNQIFDTPFGRAIVGICYESAFPEVFRSQAAAGGQFILSSSNDAHYSAAMPFQHHAQDIMRAIETDRWSARATNTGYSAFVDPHGRTLWISGYNTYETHAETIYRRQTQNLYVRWGDWFTPLLVGLSFLGWSLNIFWRNDANANSKLR
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55263 Sequence Length: 500 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q7U5S4
MGDLRSQPLLRAVLGGLLAGLAPGVAGPLSMLPALALLWSLVERPRDAALWGLFGVLLSHRWLLGLHPLTWMGLPAWLSLPVAVAIWLSCGVAAALLLLLWSLLARLCRRRDGTWRFGAVLLLALVWGAAELLLEGSPLFWIGVGGSVLPLDRPLAGLGRWLGSGGLATLQLLWGWGLWQLWRRRGRRCAWWLISLLLAHAMGALSLSPPPALAALRLGAWQPAIPTREKFSPERQRRFQSALSSALQQAQSLKVEALVAPEGTLPFRWQADEDPLPVPLISGGFRWVRGQQRSSVLLARPDRAGVEPLVDKHRLVPLGEWLPPLPAGLTRGLSAVGGLQPGDASRFVNVWPSPFAVAICYEISDGRALAKATAQGAEWLLTIANLDPYPQLLQRQFLALAQLRAIETGRDVLSVANTGPTALVSADGTVQRLLEPQTDAVAAAELQRRQQLTGYSRLVWAWSSR
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 50507 Sequence Length: 465 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q7VAT8
MLALSRSKYFAFLTGTVGGLLAGVGLSQGGVVFIWISTACLWASMAFPSAVFLWGLFAILLSYRWLLYLHPLTWIGVPIAFSLPIAILIWFSCGLLGGLLVALWSLIGQIPFFQRRLNSSTKDQLLYVIALSLIWGLVEVGLAKSPFFWFGLGDSLLPYDRWLAGLARWFGSGGLAALQLILGWWVWKIIFAFKKGSPWLGLFALGVCSLLLAHCIGWILLADNEFTSSKRIALWQTNIPTRQKFTLRELKRLPISLQDALEEADNLGADWMVAPEGTLSAGQNLLAPSPLPLLSGGFRRVKNKQMSSLLVFNEGSTSYSSAIDKHRLVPLGEWLPSLPGVNWNGLSFVGGVDPGDASRFFDWDGGPLAVAICYELSDGNNLAKAIFDGAEWILAIANLDPYPISLQRQFLALAQLRSIESARNLISVANTGPTSMILSSGKIKSIIEPFNEGVGVIDINVSQKISGYVRWGEIPLISSLLIVLCFIARLKGKA
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 54005 Sequence Length: 494 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q7V8K1
MGNDRSLALVQGAVGGVLAGIGIAHGGLLWMAPALALLWSACRFPVAASLWGFVAVLLSHRWLLALHPLTWVGVPAPLSVPVAASIWLFCGAAAAVLVGLWAWLGTSIAHLATREAGIRAQLSHALLMASIWGLAEVLLAGSPLFWIGVGGSLLPGDRALAGLARWFGAGGLATLQLLIGWWLWRTALAWRRGVGWRRSLLVGLLCLLLAHGFGWSLLRSSDATAPISVAAWQPAIPTRSKFSEEQQRRLPEALQNALDRADDLDAAWLVAPEGLLPPDAVLLRPAPLPLLSGGFRWLRGQQRSALLVVDRGERQASAFIDKHRLVPLGEWLPALPGGVFRGLSAVGGLQPGAASRLLQWPGPTAAVAICYELSNGAALAQAVADGAQWLLAVANLDPYPLALQRQFIALAQLRSIETARDLLSVANTGPSALVLATGKQQQLLAPFTEGVGLADLHFHQGISGYTRWREAPLIGLMLFAVVGLGLSRVRSWLISLMLC
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 52990 Sequence Length: 499 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
Q7V0G7
MINTQNKKFNKYFVPCLGGIFGGIATSTHFWLLFMPLSLFILWSRSDKKLANFLWGFFFILVSHSWLYELHPLTWLGFSWISSLIISISILFGCSIIGGILVYLWGLLVKKILQKKEISNMNSLRLTIKVLLLSFAWGIGEFILSQTPLFWIGLGEGIVPGDLYLAGLARWIGASGLCVVQLTIGFWIYLIYEKWKRKYHFKKTFLFGLLILVILHFLGGLTNPIERNNDYPVALWQTNMPTREKTNFKNQFINDKLISAQKIALSNDAKLLITPEGTLNNNFNLNFKSKIRMLAGGFRNSKNGLRSSLLGYQIGDKTYSSFIDKHRLVPLGEKIPGFLNIFSRGLSAVGGIQPGSDSRFFKWKFTQPLAIAICYEITDGFKIRNAVKSGAELIISAANLDPYPRKLHYQFLSLARVRSIENKKDNIIISNTGPSGLISEEGKIIKLFDPNTEQNDVVNPNFSIEKTFYTTYGERPLFLLCLFLIGLNLYFGKFTN
Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] Location Topology: Multi-pass membrane protein Sequence Mass (Da): 56347 Sequence Length: 496 Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Subcellular Location: Cell inner membrane EC: 2.3.1.269
A4VPC2
MSLLKNLLAPCLALLLAGCAALGPHESVEGPGNTAAWKEHRSHVATLDGWQISGKIGIRAPQESGSGTLFWLQRQDYFDIRLSGPLGRGATRLTGRPDAVSLEVAGQGRFEAESPEALVEAQLGWQLPVSHLLWWVRGLPAPDSRSRLSIDSESRLARLEQDGWQVEYLAYAEHNGFVLPERIRLQGHDLQITLVIKDWQPRQLGR
Function: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. Location Topology: Lipid-anchor Sequence Mass (Da): 22797 Sequence Length: 206 Subcellular Location: Cell outer membrane
Q3SLR7
MRRLAVIASLAWALGGCATVAPPPQAAIPVPLADAWTLQGRLGVQTERESLSGQIRWQHGGGVDQVLLTSPLGQGVARIVRDPEGVSLELPGQPVRRATDVDTLTRDALGYELPVAGLAWWIQARPDPLREAAVALGDDGRPARIVQDGWTIDYLQYGADARPRKLVVSRAGLEIRLVADSWQSAP
Function: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. Location Topology: Lipid-anchor Sequence Mass (Da): 19963 Sequence Length: 186 Subcellular Location: Cell outer membrane
C4LBL3
MKLLQHLTLIFCLLILTACSSRQQQPDNTNWRQQREKLESVTHWTISGKLAIITPEKKGSVRIRWQQNGDDYHLNLTSLLGTRVMEMRKTGEQIVIIDDKGQEYRGTDAEYLVYRLTGWQMPVYKLPMWIKGLPGDTDYQINPNGQVTQIKTAQWQMQYQTYQPVDGWMMPENITFKGQQTELRLVINEWKLAK
Function: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. Location Topology: Lipid-anchor Sequence Mass (Da): 22788 Sequence Length: 194 Subcellular Location: Cell outer membrane
P57070
MNALVRRLLPGLASLLLLAGCATAPLQPVNVQWQSHQVTLEQIQHYQLTGKLGYIAPDQRQSFNFQWQKSPQKLSLRLSNFLGQTVLNLQVDEQGARVETYDDQIYRDQDAQSLIRNLTGLDIPVEQLEDWILGLPTQATHYELNEQNTLATLTKLASTEEWHVEYQRYQAIEWQHQPIPLPDKLKLQQNKTSIQLVISQWTLLP
Function: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. Location Topology: Lipid-anchor Sequence Mass (Da): 23619 Sequence Length: 205 Subcellular Location: Cell outer membrane
Q87RN6
MTLRSFLIFFLSSLILAGCSSVPESVTSVEWQAHEQRLETIHDFQATGKLGYIGPDQRQSLNFFWKHSTALSQLRLTTVLGQTALKLTITPQGATVETYDDQVLSARNANQLIYRLTGLMMPVDHMPDWLLGLPTDADTFQLSPANTLQTLDKQIGLNDWKIAYERYGDVEWHEQTLPLPNKLKLTTSDVKINLVITKWNITQ
Function: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. Location Topology: Lipid-anchor Sequence Mass (Da): 23004 Sequence Length: 203 Subcellular Location: Cell outer membrane
Q1GFI8
MSEVTLKIEGLRKTYLAGTPGEVAVLRGVDLTLHAGEVVALVAPSGAGKSTLLQIAGLLDVADAGRVEIAGQDMAGARDRKRTRVRRQDVGFVYQFHHLLPEFSALENIVLPQLANGISQRDAEARGAELLALVGLETRAAHRPAALSGGEQQRVAFCRALANRPRLLLADEPTGNLDPATSDQVFEVLMQLVSETGLSALIATHNLELAARMDRVLHLEDGVLVER
Function: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. Location Topology: Peripheral membrane protein Sequence Mass (Da): 24334 Sequence Length: 227 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q5PGR6
MNKILLQCDNLCKRYQEGTVQTDVLHDVSFSIGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFSGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEIDARAREMLHAVGLEHRATHRPSELSGGERQRVAIARALVNNPRLVLADEPTGNLDARNADSIFELLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAE
Function: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. Location Topology: Peripheral membrane protein Sequence Mass (Da): 25479 Sequence Length: 233 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q2S3A3
MHRGAATQGLVFTTPLSPFILPFAVDTPLLQVDALLKQYDTGGDEPLTVLRDLDLAVQEGEILAIVGESGTGKSTLLHLLGALDRPTDGTVRFAGTDLFAKSDEELAAFRNRSIGFVFQFHHLLPEFTALENVAMPALIQHRSLADVTPRAHELLALLGLDDRADHRPRTLSGGEKQRVAIARALMNEPALVLMDEPTGNLDARTAEPLHREIERLSREMDHTFVLASHDPSLAEVAGRVLRLEHGTLHPLAAADEMAPEAGPSDDGHAGG
Function: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. Location Topology: Peripheral membrane protein Sequence Mass (Da): 29264 Sequence Length: 271 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q8EEV5
MQDVLLQVQAVSKSYHDGDVTTQVLSDVDLQVFKGEQLAIVGTSGSGKSTLLHIMGTLDKPSSGKVLLAGEDLYQVSSARQAQIRNQDLGFIYQFHHLLPEFTALENVAMPAFIQGRDRTLAQADAKVLLERVGLGHRMSHIPAELSGGERQRVAIARALINKPKLVLADEPTGNLDAKSGEAVYELIRELANQLGTAFVVVTHDPKLAARMDRQLTMKNGYLQVPESAQ
Function: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. Location Topology: Peripheral membrane protein Sequence Mass (Da): 25066 Sequence Length: 230 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q2LVM2
MIQVRNLKKTFIKDGNRIEVLRGLDLKIEDGTSLAILGVSGAGKTTFVHILGTLDHPTSGEVLFNGLDVFNWPEKKLASFRNRTIGFVFQFHNLLPEFSSLENTMMPALISGMPRRNALERAETLLHDVGLGDRMTHKPSELSGGEQQRVAVARALVMEPEILLADEPTGNLDTETGRKIEDILLELNRQKGITLIVVTHNQSLAGRMSRSIGLRDGEIVTCA
Function: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. Location Topology: Peripheral membrane protein Sequence Mass (Da): 24609 Sequence Length: 223 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q11QT1
MLDTEPVDMIPLITPEEEAEMDKEEFPSVLPILPVRNIVLFPGVVLPITVGRQKSIRLVKKFYKGDRTIGVVAQENQKSEEPSFQDIFKVGTVAKILRMFVLPDGNTTIIIQGKRRFKIEEQVQDEPFMQAKVSMLKDIHPDMSKKEVKALLQSVKESATKILKMNPEIPQDAQIAINNIESENFLTHFLSSNINAELKDKQKLLEFDDAVERATWLLQLMDKDIQMLEIKREIHTKVHTDIDQQQRDYFLRQQIKVLQDELGDFSSEQEFERLKEKALTKKWSDKVRAHFDKEMSKLQRVNPMAPDYPVTFNYLELLVDLPWGENSTDNFDLVRAKEILDEDHFGLTKVKQRILEYLAVLKLKNNMKAPILCLYGPPGVGKTSLGKSIAKALDRKYIRMSLGGVHDESEIRGHRKTYIGAMPGKIIQGIKRSETSNPVFILDEIDKISKDFRGDPSSALLEVLDPEQNSSFMDNFLEVEYDLSKVLFIATSNALDTIQPALRDRMEIIEINGYTLEEKIQIAKKYLIPKQKEEHGLKAKDISFTDAAIVKIIEDYTRESGVRNLERKIGAVVRNIAVAIAMETAYTKKIQPAQVREILGSEDFEKDTYQQDDLAGIVTGLAWTPYGGEILTIESIISKGKGKLTLSGQLGDVMKESASAALSLLRANVDAIGIDHRVFDHFDLHVHVPAGATPKDGPSAGIALYTSLASTFTQRKIKPALAMTGEITLRGKVLPVGGIKEKILAAKRAGIKEIILSKKNKKDIEEIHPPDIADLKFHFVETADEVLAIALLKQKIKKPFNLEVPEEPKKKDK
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 91748 Sequence Length: 813 Subcellular Location: Cytoplasm EC: 3.4.21.53
Q9RXG4
MPDSTALPTTIPVCPVRGSVIYPTMVQHIDASRAISINAIEAAMSGEKVILIVSQRDKDVDDPKGEDLYDVGTACNVLRVRKNPDGTLQMLVSAVARVQVSAYQLGDYLTADIEPLDAGKSGGVELQALSRELKDKFETVASGGRINAESVQTINSKDDIGEMADHIAFNLDFKLEDKQAILEAANVTERLKKLLTLLDTEQEVQAVQAKIRAQVKEEIDKNQREYYLREQMKVIQKELQGGDEEEGDEAEAFRAKIDALGLNPEVKKEIDREVNRLARMHPDAAEASVIRTYLTWVTELPWNERSDDRLDVEEAAQVLDEDHYGLEKVKDRVLEFLAVRRLRKERAERGEISAEEVNKGPILVFTGPPGVGKTSIAQSIAKSLGRKYVRIALGGARDESDIRGHRRTYIGAMPGRIIQGIRTAGTKNPVILLDEVDKLGSSYQGDPSSALLEVLDPSQNQHFTDHYLGVPFDLSEVMFIATANYPEQIPAALMDRMEVIEFNSYIEQEKLEIAKRYLLPRQLLQNGLKPNQISFSDAALEKLISHYTREAGVRNLEREIGTVARKVARNIATGKTKRAKVTDKELEKYLGQPRHTPETENMEDMVGVSTGMFYTPVGGDILFVETSIMTGKGGGLLLTGQLGDVMKESARAALTYAKSNAERFHIDREKLDNSEIHVHVPAGAIPKEGPSAGGAMATSLISALTGIPARHDVAMTGEMTLTGRYLPIGGLKEKVLGARRAGIKHIILPKANERDINDIPLHLRSSMRFHPCETVDQVLDVALVGGLKALETPRTDSQVTPPADSGSKGRKTGRRSPEARA
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 90363 Sequence Length: 821 Subcellular Location: Cytoplasm EC: 3.4.21.53
B8F9K1
MAHTDTDDLVGLLDADDQNLDIPATLPMLPVRDVVVFTHMIIPLFVGRDKSVRAVDAAMAKDRFLFLATQMDGAVENPESDQIFKHGTAARILRVLKLPDGRVKVLVQGLAKAKIVRYTKKSDMFRVRIELLHEEDLGDLDMETEALMRNVKESCEKILGLRGELTPDVTMVLDGIDHPGRLADLVASNLNLKIEEAQSIFETIDPVQRLLAVNGFVSREVELSAMQARIQSSVRDEISKSQKDYFLREQMRAINRELGEMDEKTQEIKEYQDKIRKAKMPKEAKEEAERQLKRLEQMHPEAGEAPTVRTYLDWLVEVPWKKATKDTLDIKKAKEILEEDHYGLEKVKDRILEYLAVRKLNPKMKGPILCFVGPPGVGKTSLGKSIARAMGRKFYRLSLGGIRDEAEIRGHRRTYIGALPGRIIQGLKHCKSNNPVFMMDEIDKIGADFRGDPSSALLEALDPEQNFAFSDHYLNVPFDLSSVMFITTANMTDTIPSALLDRMEVINLAGYTENEKVLIAQQYLVPRQVKENGLKPEDITISGNALLKMATEYTSESGLRNLEREIGTLCRKVSRKIAEGKKGPYQITASSLVKYLGLEKFLPEMDQEEPQIGLATGLAWTHWGGEALYIETTLMRGKGELVLTGQLGEVMQESARAALSYARTNEDELEIDPDLFDNFDIHIHVPAGAIPKDGPSAGIAMTTALVSALTERPVANDIAMTGEVTIRGRVLPIGGLREKSLGALRAGIKTIIIPEKNKKELSEVPQQVRRKLKYITVSHVNEVLEKALLPAEKKKAPPKKKPPKKAAKPKAKKTQPKAKTTEAADK
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 92194 Sequence Length: 826 Subcellular Location: Cytoplasm EC: 3.4.21.53
A8ZX50
MAQPKIPEYKANGTTDKLPETVPIMPLSDGVLFPKMIIPVVITQNEYMTLIDEVMSGNRLVALITPKSGERKSDYGPGDLSPIGTLALILKMAKPDESRIHLMLQGISRIRTKNFIKTDPYLEAAFAQITENEKKDKETEGLMSNISNVYQELVRISPAIPNELGAMAVTIDEPGSLADMVASTINSSTEEKQNILETLDVKLRLKKVTRQLNHQLEILKLGDKIQSQIKEDMDKQQKEFYLRKQLKAIREELGEKEEGNVEAEEYRTKIEEGNLPEEAYKAATRELERFSRMHPSSSEYTVSSTYLDWLTTLPWDKQTEDHLDIKKARAILDKDHFGLEKPKKRILEYLAVRKLNPDSKGPILCFLGPPGTGKTSLGRSIARALGREFIRISLGGVRDEAEIRGHRRTYVGALPGRIIQEIRKAGTNNPVFMLDEIDKVGADFKGDPSSALLEVLDPEQNFSFADHYLDVSFDLSRVMFVATANVIDTIPPALRDRMEVIGLRGYTLEEKVKIARQYLIPRQRKENGLAAKHISFSQSAIRHIISDYTREAGLRNAEREIASVCRGVAAKIAEGKKVSGAIKPEDLYEYLGPVRFTSETGENALTPGVVMGLAWTPVGGEILFIEATSMKGKRGLTLTGQLGDVMKESATAALSFIRAHARDYDIDEDFFDKYDFHIHVPSGAIPKDGPSAGVTMLTALVSLLTGRKVKKGLAMTGEITLRGKVMPVGGIKEKVIAAHRAGIKEVILPRPNKKDLEEIPAKVKSAMKFHFAEKMGDVLELALNGNGATKKKKKTPAKSKKSTKPAAKKTAARKSRK
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 90649 Sequence Length: 817 Subcellular Location: Cytoplasm EC: 3.4.21.53
A4J7L6
MNSEIKSLPLLPLRGILVFPYMVIHLDVGREKSIQAIEEAMVQDRMIFLATQREAQTDEPTVDDIYNIGTVAEVKQLLKLPGGTIRVLVEGIARAKIEKYEHQDPYFRVEVQQYSEEFEKGAEVEALMRSLVYQFEQYVKLSKRIPPETVVSVVNLEEPGRLADIIASHLALKIEDKQNVLESVEIVDRLEKLCGIVAKELEIVELERKINIRVRKQMEKTQKEYYLREQMKAIQKELGEKDERVAECEEFREKISKAKFPKEAEEKALKEVERLEKMPPMAAEAAVVRNYLDWMLSLPWSKSTKDRIDINAAEEVLEADHYGLKDPKERITEYLAIRKLAKKMKGPILCLVGPPGVGKTSLGRSVARALDRKFVRISLGGVRDEAEIRGHRRTYVGAMPGRVIQGMRTAGSKNPVFLLDEIDKMASDFRGDPSSALLEVLDPEQNSTFSDHYIETPFDLSNVMFITTANNMYSIPRPLLDRMEVIQISGYTEEEKLQIAKRHLMPKQIKDHGLTEEMIQISENTILKVIREYTRESGVRNLERKIASICRKTAKKIVAGQAEKVKVTTQNLEQFLGIPRYRYGVAEQNDEVGTVTGMAWTEVGGDTLVIEVTTYKGTGRMTLTGKLGDVMKESAQAGYSFIRSRAQELGIDQEMFEKWDLHIHIPEGAIPKDGPSAGITMATAMASVLTGRKVRHDIAMTGEITLRGRVLPVGGIKEKVMAAHRAGIKLIILPNDNKKDLEDIPVNIKKQLEFKLVDHIDQVLAIALLEKEVVDTTTVLEPEAAVMDNPHFSAVDSQEVQQQGGTQLPS
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 91333 Sequence Length: 810 Subcellular Location: Cytoplasm EC: 3.4.21.53
Q72CE6
MTDTGREGLQNREEGFELPLMSLREVVMFPRSIVPLFVGREASIKAIESAISDYGKKIFLVAQREPELEKPGPEDLFEVGTVSKILQLLRLPDGTIKVLFEGLYRARWDGTADAIIGADDAYPRVRVTRIEQESSEDDDEALVRATHEALDEYGKINKKLAQETLVAISALSDAARLADAIMPHLKVDYRRKQELLEVESGAERLEKVYELLQGEIAVASLEKRIKSRVKNQMERNQREYYLNEQIKAIHKEMGREDDPQAEVNELEARLAEKSMPEEAREKALREMKKLRQMPPSSAEYTVVRNYVDWILDLPWNTLKETEIDIDNARSILDADHYGLEKPKERILEYLAVQKLVNRLKGPILCLVGPPGVGKTSLAKSVAKATGREFVRLSLGGVRDEAEIRGHRRTYVGALPGKIIQSLKRVKHNNPLFCLDEIDKMSTDFRGDPSSALLEVLDPEQNSTFNDHYLDMDYDLSQVFFITTANSLHSIPLPLQDRMEIIRLPGYLETEKRRIAHDFLLPKQVEAHGLAASNLRISDNAVLEIIRSYTREAGVRNLEREIASVCRKAAMQVVEAGDKEKTLTVSRQNLGNFLGVKKYRHGEREDTSQVGVCTGLAWTEMGGELLVVETALMPGSGRVEITGKLGDVMTESAKAALSYLRSRSDLFGLRPDFHKEIDIHVHVPEGATPKDGPSAGITLATSMVSALLGIPVRNDVAMTGEITLRGRVLPIGGLREKLLAAHRGQIGKVLVPRENEKDLKEVPGEILKGLEIVFVDHVDEVLPQALMAQAESIFGGRTQSTPLYAKLRKDAQDGGATMPTAQ
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 91617 Sequence Length: 821 Subcellular Location: Cytoplasm EC: 3.4.21.53
A5EWF3
MTDKIYPILPLRDVVVFPHVIVPLFIGREKSIAALDAAMNGSQELLLVPQRDPAVVEPTLADLHEIGSLGRIVQMAKLSDGTVKALVEGLYRVHLEALNDDEKMFSAKKRNMLEKNSTKSEEHDSIVEILIEEFAKYLRNQERSADELLETLRGINDIGRISDTIAAHMDFRIEERVHLLAMEDAYERSQRLMILLAQESEKNELNKKIKNRVKQQMERNQREYYLNEKIKAIQKELGEMDEAQNDIELLEAQIKKAKMPVDVEKKALSELNKLKQMSAMSSEANVIRNYLEWLIDYPWAIEKPARYDLEEAARILDRDHYGLEDVKERILEYLAVQKRINEHNQKEAGTIGKGPIICLIGPPGVGKTSLGKSIAEATGRDFDRIALGGLHDEAEIRGHRRTYIGALPGKIVQKLCKLGSNNPVILLDEIDKIGHDHHGDPAAALLEVLDPAQNHTFNDHYLETDIDLSNVLFIATANTLNISEPLLDRMEVIRLPGYTTQEKIQIAKRYIVPRQRKENVLKASEFKIKNGVLNDVIEDYTREAGVRNLEREIGKLARKSVRRLQEGKQKSILITPNNLKDFLGVAKYHRNDEDLQAKIGSVTGLAWTSVGGELLQIEGVAFSGKGRLTHTGQLGDVMQESIRTALSVVRSYLDDLDDNFRFDEYDIHLHLPEGATPKDGPSAGIAMATALLSALSKQAVRGDLAMTGEITLHGKVLAIGGLKEKLLAAQRGRLKMVLIPEDNLKDLDEIPEEVKAALEIVPVSHIHEVFDHAFVADHAPFKARIEQKSLPTVSAVMHETPAGRC
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 90289 Sequence Length: 805 Subcellular Location: Cytoplasm EC: 3.4.21.53
B5YFG2
MEERELNQTQDIPEVLPILPLRETVVYPQMLIPLIVGREKSIRLVEDALSGNKLIGMCMQKTPVEDPTPDDIYRIGTVGIIVRSLRFPDNTLRLFVQGLQRIRVIEFLETEPYFKAKVEVIEEKVEKTVEIEGMMRNLLNLFQKMASLIPQFPEELLINAMNIQEPGRLADFIAFNTNLNINEKQEILETIDVKERLQKVTYYLTRELEILEIANKIQNEVKNEIEKSQKEYFLRQQMKAIQKELGEIDPREMEINELRQKLQEAKLPPEAMKEAERELERLSLMPPGSAEYTVTRTYLDWLISLPWAISTEDNLDIKRAEEILNEDHYDLEKVKERILEYLAVRKLKSDMKGPILCFVGPPGVGKTSLGKSIARALGRKFVRISLGGIRDEAEIRGHRRTYVGALPGRIIQGIRKAESNNPVFMLDEIDKLGSDFRGDPAAALLEVLDPEQNNAFVDNYLGVPFDLSKVMFIATANVLYTIPPALLDRMEVIELPGYTEYQKMGIAKGFLIPRQLKEHGLEKEQIEFSDDAIRKIIREYTREAGVRNLEREIASIIRKVAKGIAEGSITEKVIVKVEDVPKYLGPEKYTYGMKGEKDEVGVATGLAWTEAGGDILFVEALVVEGKGNLILTGKLGEVMQESAKTALSYVRSKLKDLNVSYELLEKADIHVHVPSGAIPKDGPSAGVTIATAIASALTRRPVKKDIGMTGEITLRGKVLPVGGIREKVLAAHRAGLTAVIMPKENKKDLEEIPEEVKKEITFYFVEHADEVLNLALLEVKESAEQRNPERIG
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 89422 Sequence Length: 792 Subcellular Location: Cytoplasm EC: 3.4.21.53
B2KCC0
MIAENKDYVKPDVNTLPAVLPAVAIRDVVMFPGMSLPLSVSRSKSIAAINLALDSNKYVVAVAQKEAEVEDPKAEDIYRFGVLSEITQSLKMPDGSIKVFLQGIARVKIEHLDFNNIANSWFASVFYPADEKVSGPEVTALMRQLLDEFEEYATVSRRIAVEGVSFFRQIEDPSRLADTIASNIIVKTSDRQDVLEAVNPKDRLELLIKILANEVEIISLEEKIHSKVRAQIEKNQKEYYLNEQMKAIQKELSQKDDFQKEIDELRSKIKKNGLPKNAKESAEKELDRLAKMAPFSPESTVSRTYLDWLVNMPWNSSTNDILDLKKAKEVMDADHYGLDKPKERILEYLAVSKLTNSLKGPILCFAGPPGVGKTSLAKSIASAVGRKFVRMSLGGVRDESEIRGHRRTYIGSMPGRIIQGISKAKSNNPVFLLDEIDKMGSDWRGDPAAALLELLDPEQNKDFSDHYLDVPFDVSKVMFITTANSLSSIPVTLRDRLEIIDFSGYTEYEKEAIAQNHLIPRQMKEHGLKEGSLEIGLPAVKLIMRDYVREAGVRNFEREISTICRKAAKMYVENCGKTVTVTKDNLHDFLGVPRYTNFTTEENGVGISTGLAWTSVGGETLSIEASEISDGKGRIMLTGKLGDVMKESVHAALTYARSKGYGKGIDFNKTDFHIHFPEGAVPKDGPSAGTAVTTALISLLTKNPVKKNLAMTGEVTITGRVLPIGGVKEKFMAAYREGVKTILYPHTNEKDVSEVPEVIRKQLKLIPVKHMDEIVKIAFEKGEPKSSFKKSKTAPKKESAKKAAKSKKPAVKKPAVKKTKQVKKTAKKKK
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 92244 Sequence Length: 830 Subcellular Location: Cytoplasm EC: 3.4.21.53
A7HK39
MPNKNDNKGKYSRLEKEAKKAREEKISIPNVLPAIAMRSNMVIFPNTVVPFYVGREISLMALEEAMEKTNQIVFVVNQKDPAVETPTEKDLYKVGTIVRIIQVGKLPDETFKVLVEGIARAKWIKNVGEKFFKFEIEILRTRYGKSKRLIALMRMVKEELHKYVQYSRKIPPETLMLLEDVDNPDVFADIAASLCPGNIEEKQQLLEIVHPANRLERILDILARETELLEIEQQLDQKVKERIEKSQREYYLREKLRVIRDELGGEEDIEIKELKEKIENNNYPEFVKEKARAEINRLEKMSPYAPEATVVRTYLDWILNLPWHEKTDDTDDINFAEKVLNEDHYGLDEPKRRILEYLATRKVSQKAKAPIICFVGPPGVGKTSLAKSIARAMNRKFGRMSLGGLRDEAEIRGHRRTYVGAMPGRIMQLIRKLGVKNPVILLDEIDKMGISFQGDPASALLEVLDPEQNKEFVDHYIELPYDLSEVLFVTTANVLYTIPPALRDRMEVIEISSYTDVEKFYIAKNYIIPKIESEFVEKADEIFSFKDTAIKKIINEYTLEPGVRELEREIRSVVRKATLDAIKTGKKIVISPEKVTEYLGPSKIKDEDKLEKPMIGVTTGLAWTPNGGTTLYIESTLIPGNGGLIITGQLGDVMKESVRIALSLARKIVGDEYAEKFTKNDIHVHVPEGAVPKDGPSAGVTITTALVSVVKNIPVRNDIAMTGEITLRGRVLPVGGIKEKVMAAYRKGIYHVILPKKNEVDIEKVPEVVRTKMKFTFVETIEEVLEVALNEDNSKESRKGRTRKGNSNTK
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 92111 Sequence Length: 810 Subcellular Location: Cytoplasm EC: 3.4.21.53
B0S2N4
MKEYYTISEKKLPIIALRGLWLFPNNIQHFEVGREVSLNALNASLLRNSEIFICTQKDPMLENITKEDFYHTGVLASIKQTIKMPNGNIRVLVEAYDRAKIVDFVENDSFLEANVEVMEYDKTKYHPTDKSLTMIRMIISSFESLAEIIKKPLPQDLLGGLLNEEDPSSLIDTIAMLISLNDKDSILLLETLDMDERIELVYKFVIKEIEFLKIKEDIEERTNKEISDTQKEYFLQEQLRQIKMELGEEYDIEDTDDYANRVKKLKLKKDSEEHVLKEINRLSSMNPNNPESTVIRNYIDQVLDIPWNKKSKSSIDLKVAEKVLNDGHFGLEDVKKRILEYLAVKKMTGSLKGPILCLVGPPGVGKTSIARSIADATNRKFVSMRLGGVRDEAEIRGHRKTYIGAMPGRIITQLQKAKKLNPVFLLDEIDKLASDFRGDPASALLEVLDPEQNSEFTDNYIEIPVDLSDVLFITTANSQEQIPDALLDRMEVIRVTSYTDSEKFEIANRYLLPRQLKENGMDKSQFHITRDAIYTIINNYTRESGVRELERNIGKVIRKAVVKIVKDDVKKVVVNNKNLEKFLGSKLVLDDEIPREDTVGVVNGLAWTQVGGVILTIEANVMDGSGKTQLTGKLGDVMKESAMAAISYIRSNQEALGIKGEFYKEKDIHIHVPEGAVPKDGPSAGVTMVTALVSALTGRKVKHDFAMTGEITLTGRVLAIGGVKEKVLAAHRYGINKVFLPKENKRDIQDIDPKIRQKIKFYFTSNVKEILDEVLI
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 87866 Sequence Length: 776 Subcellular Location: Cytoplasm EC: 3.4.21.53
Q0RPW3
MTQLPHVRVDHMPQIRVLPVLPLDDAVVLPGMVVSLDMSDEQTRAAVDAARTGGSAGSSDARAPGISSRAAGRPAEVLLVPRVGGELAEVATVGVIEQVGRLPRGGSAAVVRGTARAQVGGVRPAPAGTDTTGTGTADATSGAGSGAGVQWVDAVVLDDSAATPFGALDDPAGTRAGSPADEAARVDKLAKEYRALVTDLLRQRGAWQVVDSVSAITDPGTLADTAGYSSYLTTAQKIELLGTPAVGTRLERLLTWTKEHLAEQDVAETIRRDVQEGMDRQQREFLLRRQLEAVRKELSELDGSGGGADGASGSEPADYRARVEAADLPEKVRAAALKEVDKLERTSDSSPEGGWIRTWLDTVLDLPWNVRAEDSYDIIAARAVLDADHAGLDDVKDRIIEHLAVRRRRADAGLGVVGGRRGGAVLALAGPPGVGKTSLGESIARAMGRSFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIREAGSMNPVVLLDEVDKLGADYRGDPTAALLEVLDPEQNHTFRDHYLEVELDLSDVLFLATANVLEAIPAPLLDRMELIRLDGYTEDEKVVIARDHLLHRQLDRAGLAEGDVSVGDDALHALAGEYTREAGVRDLERSIARLLRKVVAQVALGAAALPVTIDAGDLTGYLGRPRHTPESAERTALPGVATGLAVTGAGGDVLFVEASLADAETGGGGITLTGQLGDVMKESAQIALSYLRSHGVELELPVGDLADRGVHVHVPAGAVPKDGPSAGVTMTTALASLLSGRPVRADVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGLTTVLLPQRNGPDLDDVPAPVRDALTVHLVTDVREVLDLALEPAFDADHGGRSPGRAGHSPTALAA
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 91415 Sequence Length: 874 Subcellular Location: Cytoplasm EC: 3.4.21.53
B0TZA7
MSEVLNVVPVIPLRDVVIYPSMTLPLNVGRKKSIEAVKQASNSYNNYILLATQKNGSSSGDVVDNIYDIGTLAKVVQIMKLPDGSLKIIVEGIAKRLVAKYESIDGCIYANLDSLHIDDNYDPSQIDKELKAILLSITDSLKKFVDISGKVSKESLATLINTEEPHKFIYEISTILNTEIAKKQKILEATDIKNKALLLLSCLYEELEILELEAKIKDRVKSQVDKNQREYYLNEQVKAIYKELGEADEESEVTALKSRIEATKMSKEAKEKCLKELKKLKAMPPSSSESAVSRNYIETILSLPWGKKAKVKKDINLAEKVLEKDHYGIKKVKERILEHLAVQIKRDTNAKAPILCLVGPPGVGKTSIGQSIARATGREYVRMALGGVRDESEIRGHRRTYIGSMPGQIIQKIIKSKTENPLFLLDEIDKISSDFRGDPSAALLEVLDPEQNSTFNDHYLEIDYDLSKVMFVATANSLDIDPALRDRLEIIHLSGYTEIEKQAIAKQYLVPKALENNGLTKNEINFTPKATLDIIRYYTREAGVRNLQQKIDGVCRKAVKNLLKDPEHGKVSITQNNLEDYLGVHQFDYGIKNAKPKVGQVTGLAWTSVGGELLTIEALAMPGKGKVKYTGSLGDVMKESIDAAFSVVRSISKDYKLEDDFYEKKDIHIHVPEGATPKDGPSAGIAMTTALVSVYTNKPVRNDIAMTGEVTLRGDVLAIGGLKEKLLAALRGGIKEVLIPKQNVKNLADVDKEILEKLEITPVNSIKEVLERVF
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 85998 Sequence Length: 774 Subcellular Location: Cytoplasm EC: 3.4.21.53
Q8RHK0
MLKAPFLPIRDLVIFPNVVTPIYVGRANSIATLEKAIANKTKLVLGLQKDASQENPTFDGDIYEVGVIANIVQIIRMPNNNIKVLVEAEDRVKIKNIEKEENEYVTTYTVIKETLKDSKETEAIYRKVFTRFEKYVSMIGKFSSELILNLKKIEDYSNGLDIMASNLNISSEKKQEILEISNVRDRGYRILDEIVAEMEIASLEKTIDDKVKNKMNEAQRAYYLKEKISVMKEELGDFSQDDDVIEIVDRLKNTELPKEVREKLEAEVKKLTKMQPFSAESSVIRNYIEAVLELPWNSETNDVLDLKKASQILERDHYGLKDAKEKVLDYLAVKKLNPSMNGVILCLSGPPGIGKTSLVKSIAESMGRKFVRVSLGGVRDEAEIRGHRRTYVGSMPGKIMKAMKEAGTNNPVMLLDEIDKMSNDFKGDPASAMLEVLDPEQNKNFEDHYIDMPFDLSKVFFVATANDLRNVSAPLRDRMDILQLSSYTEFEKLHIAQKFLLKQAQKENGLANIDIKIPDKVMFKLIDEYTREAGVRNLKREIITICRKLAREVVEKDTKKFNLKPTDLEKYLGKAKFRPEKSRKATGKIGVVNGLAWTAVGGVTLDVQGVDTPGKGEVTLTGTLGNVMKESASVAMTYVKANLKKYPPKDKDFFKDRTIHLHFPEGATPKDGPSAGITITTAIVSVLTNKKVRQDIAMTGEITITGDVLAIGGVREKVIGAHRAGIKEVILPEDNRVDTDEIPDELKSTMKIHFAKTYDDVSKLVFVK
Function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Catalytic Activity: Hydrolysis of proteins in presence of ATP. Sequence Mass (Da): 86349 Sequence Length: 768 Subcellular Location: Cytoplasm EC: 3.4.21.53
P58215
MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
Cofactor: Contains 1 lysine tyrosylquinone. Function: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins . Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin . Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity . Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated . Also able to catalyze deacetylation of lysine residues on STAT3 . PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Catalytic Activity: H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) Sequence Mass (Da): 83166 Sequence Length: 753 Subcellular Location: Secreted EC: 1.4.3.-
Q9Z175
MRAVSVWYCCPWGLLLLHCLCSFSVGSPSPSISPEKKVGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHVLCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCRGTEGSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHQLQVEEVRLRPAVEWGRRPLPVTEGLVEVRLPEGWSQVCDKGWSAHNSHVVCGMLGFPGEKRVNMAFYRMLAQKKQHSFGLHSVACVGTEAHLSLCSLEFYRANDTTRCSGGNPAVVSCVLGPLYATFTGQKKQQHSKPQGEARVRLKGGAHQGEGRVEVLKAGTWGTVCDRKWDLQAASVVCRELGFGTAREALSGARMGQGMGAIHLSEVRCSGQEPSLWRCPSKNITAEDCSHSQDAGVRCNLPYTGVETKIRLSGGRSRYEGRVEVQIGIPGHLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNVTEVVMSGVRCTGSELSLNQCAHHSSHITCKKTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQIV
Cofactor: Contains 1 lysine tyrosylquinone. Function: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins . Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin . Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) . Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity . Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues on STAT3 (By similarity). PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Catalytic Activity: H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) Sequence Mass (Da): 83740 Sequence Length: 754 Subcellular Location: Secreted EC: 1.4.3.-
Q96JB6
MAWSPPATLFLFLLLLGQPPPSRPQSLGTTKLRLVGPESKPEEGRLEVLHQGQWGTVCDDNFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRCVGTESSLDQCGSNGWGVSDCSHSEDVGVICHPRRHRGYLSETVSNALGPQGRRLEEVRLKPILASAKQHSPVTEGAVEVKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHYYRKVWDLKMRDPKSRLKSLTNKNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPKTKPQRKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGARLGQGLGPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPNMGFQNQVRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKETWFWSGTPRAQEVVMSGVRCSGTELALQQCQRHGPVHCSHGGGRFLAGVSCMDSAPDLVMNAQLVQETAYLEDRPLSQLYCAHEENCLSKSADHMDWPYGYRRLLRFSTQIYNLGRTDFRPKTGRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACANFGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI
Cofactor: Contains 1 lysine tyrosylquinone. Function: May modulate the formation of a collagenous extracellular matrix. PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Sequence Mass (Da): 84483 Sequence Length: 756 Subcellular Location: Secreted EC: 1.4.3.-
Q924C6
MMWPQPPTFSLFLLLLLSQAPSSRPQSSGTKKLRLVGPTDRPEEGRLEVLHQGQWGTVCDDDFALQEATVACRQLGFESALTWAHSAKYGQGEGPIWLDNVRCLGTEKTLDQCGSNGWGVSDCRHSEDVGVVCHPRRQHGYHSEKVSNALGPQGRRLEEVRLKPILASAKRHSPVTEGAVEVRYDGHWRQVCDQGWTMNNSRVVCGMLGFPSQTSVNSHYYRKVWNLKMKDPKSRLNSLTKKNSFWIHRVDCLGTEPHLAKCQVQVAPGRGKLRPACPGGMHAVVSCVAGPHFRRQKPKPTRKESHAEELKVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGAQLGQGLGPIHLSEVRCRGYERTLGDCLALEGSQNGCQHANDAAVRCNIPDMGFQNKVRLAGGRNSEEGVVEVQVEVNGVPRWGTVCSDHWGLTEAMVTCRQLGLGFANFALKDTWYWQGTPEAKEVVMSGVRCSGTEMALQQCQRHGPVHCSHGPGRFSAGVACMNSAPDLVMNAQLVQETAYLEDRPLSMLYCAHEENCLSKSADHMDWPYGYRRLLRFSSQIYNLGRADFRPKAGRHSWIWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPSGVQRRYACANFGEQGVAVGCWDTYRHDIDCQWVDITDVGPGDYIFQVVVNPTNDVAESDFSNNMIRCRCKYDGQRVWLHNCHTGDSYRANAELSLEQEQRLRNNLI
Cofactor: Contains 1 lysine tyrosylquinone. Function: May modulate the formation of a collagenous extracellular matrix. PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Sequence Mass (Da): 84779 Sequence Length: 757 Subcellular Location: Secreted EC: 1.4.3.-
P24095
MFGIFDKGQKIKGTVVLMPKNVLDFNAITSIGKGGVIDTATGILGQGVSLVGGVIDTATSFLGRNISMQLISATQTDGSGNGKVGKEVYLEKHLPTLPTLGARQDAFSIFFEWDASFGIPGAFYIKNFMTDEFFLVSVKLEDIPNHGTIEFVCNSWVYNFRSYKKNRIFFVNDTYLPSATPAPLLKYRKEELEVLRGDGTGKRKDFDRIYDYDVYNDLGNPDGGDPRPILGGSSIYPYPRRVRTGRERTRTDPNSEKPGEVYVPRDENFGHLKSSDFLTYGIKSLSHDVIPLFKSAIFQLRVTSSEFESFEDVRSLYEGGIKLPTDILSQISPLPALKEIFRTDGENVLQFPPPHVAKVSKSGWMTDEEFAREVIAGVNPNVIRRLQEFPPKSTLDPTLYGDQTSTITKEQLEINMGGVTVEEALSTQRLFILDYQDAFIPYLTRINSLPTAKAYATRTILFLKDDGTLKPLAIELSKPHPDGDNLGPESIVVLPATEGVDSTIWLLAKAHVIVNDSGYHQLVSHWLNTHAVMEPFAIATNRHLSVLHPIYKLLYPHYRDTININGLARQSLINADGIIEKSFLPGKYSIEMSSSVYKNWVFTDQALPADLVKRGLAIEDPSAPHGLRLVIEDYPYAVDGLEIWDAIKTWVHEYVSLYYPTDAAVQQDTELQAWWKEAVEKGHGDLKEKPWWPKMQTTEDLIQSCSIIVWTASALHAAVNFGQYPYGGLILNRPTLARRFIPAEGTPEYDEMVKNPQKAYLRTITPKFETLIDLSVIEILSRHASDEIYLGERETPNWTTDKKALEAFKRFGSKLTGIEGKINARNSDPSLRNRTGPVQLPYTLLHRSSEEGLTFKGIPNSISI
Cofactor: Binds 1 Fe cation per subunit. Iron is tightly bound. Function: Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Catalytic Activity: (9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate Sequence Mass (Da): 96817 Sequence Length: 864 Pathway: Lipid metabolism; oxylipin biosynthesis. Subcellular Location: Cytoplasm EC: 1.13.11.58
Q44467
MNNNDIEYNAPSEIKYIDVVNTYDLEEEASKVVPHGGFNYIAGASGDEWTKRANDRAWKHKLLYPRLAQDVEAPDTSTEILGHKIKAPFIMAPIAAHGLAHTTKEAGTARAVSEFGTIMSISAYSGATFEEISEGLNGGPRWFQIYMAKDDQQNRDILDEAKSDGATAIILTADSTVSGNRDRDVKNKFVYPFGMPIVQRYLRGTAEGMSLNNIYGASKQKISPRDIEEIAGHSGLPVFVKGIQHPEDADMAIKRGASGIWVSNHGARQLYEAPGSFDTLPAIAERVNKRVPIVFDSGVRRGEHVAKALASGADVVALGRPVLFGLALGGWQGAYSVLDYFQKDLTRVMQLTGSQNVEDLKGLDLFDNPYGYEY
Cofactor: Binds 1 FMN per subunit. Function: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2 . Cannot oxidize D-lactate, glycolate, and D,L-2-hydroxybutanoate . May be involved in the utilization of L-lactate as an energy source for growth (By similarity). Catalytic Activity: (S)-lactate + O2 = H2O2 + pyruvate Sequence Mass (Da): 40933 Sequence Length: 374 EC: 1.1.3.-
F4G5A4
MSPSDRIPPGVWNAIDYERLAPQAMDAGRHAYVAGGCGWDATVAANRAAFAGWAVLPRLLRDVRAGHTRLQLAGMDLPHPLLLAPVAHQRLAHPDAEIATARAAQATGSCLVASTLSSCTLEDIAAASGPARWFQLYLQPEREHSLDLLRRAEAAGYRAIVLTLDASIQLASRGALQAGFAMPADCVSANLARYPQPAPAQPAAGESRIFQGAMRHAPRWDDLRWLLASTRLPVWIKGVLHPEDARELQAAGAAGLIVSNHGGRSLDGAPASLRMLPALRTAVGAGYPLLLDGGVRSGQDAFKALALGADAVLVGRLQVYALAVAGALGVAHMLQMLVEELHACMAQAGCARLSDITHDTLTPSC
Cofactor: Binds 1 FMN per subunit. Function: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2. To a lesser extent is also able to use glycolate as substrate. Catalytic Activity: (S)-lactate + O2 = H2O2 + pyruvate Sequence Mass (Da): 38409 Sequence Length: 365 EC: 1.1.3.-
F8WQN2
MADLSFLNLEEVEEEAKKVMPKMAFDYYSTGSDTCYTVGENRSCFSRYLLLPRMLRNVSRVDTSHELFGIRSSMPVWVAPMAMHGLAHPGREVATCRAAAAAGVPFTFSTVATSSLQEIQETGHDNRIFQLYVIRNREVVRRWVTEAESRGFKALMVTVDAQRLGNREADARNKFTLPPGLALRNLEYLSSASTVQARDSQDGSGLMKLFTSEVDDSLTWEFIPWLRGVTKLPIIVKGLLSPADAELAVQYGVDGIVVSNHGGRQLDYAPSGLHMLPAVVAAVRGCGSSIPVLVDGGVRRGTDVIKALALGASGVLLGRPVLYGLAVGGQAGVERVLQLLRSEIELSMALAGCSSVQQIGPQLLLPAPSAGPAPPMPAAQLCKL
Cofactor: Binds 1 FMN per subunit. Function: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2. Also shows a low oxidase activity with glycolate in vitro. The very low glycolate oxidase activity indicates that this enzyme is unlikely to be involved in photorespiratory glycolate metabolism, a pathway in which the oxidation of glycolate is taken over by glycolate dehydrogenase (GlcD). Catalytic Activity: (S)-lactate + O2 = H2O2 + pyruvate Sequence Mass (Da): 41308 Sequence Length: 384 EC: 1.1.3.-
A0A5N1I561
MTVYYKGFPQSDRNEAIKMVNVDELEDRVRKVMPEAAYYYIASGSENEWTWRNNTAAFNHFQIVPRSLTNMDNPSTETQFMGMDLKTPIMICPIACHGIAHKDAEVATAQGAKAAGALFSSSTYANRSVEDIATATGDSPKFFQLYLSKDWDFNKMVFDAVKSAGYKGIMLTVDALVSGYREANLRTNFTFPVPLDFFTRYVGAEGEGMSVAQMYANSAQKIGPADVAKIKEMSGLPVFVKGVMNAEDAYMAIGAGADGIVVSNHGGREIDTAPATIDMLPEIAAAVNGRVPIILDSGVRRGSHVFKALALGADLVGIGRPFLYGLALGGAKGVESVINQINNEFKILMQLTGCKTVEDVKHADIRQINYTADNLPSNTDPSVRRAYPVTKENQMEGTQDAATGASKH
Cofactor: Binds 1 FMN per subunit. Function: Oxidase that catalyzes the oxidation of a broad range of 2-hydroxyacids in vitro, such as (S)-lactate, 2-hydroxyoctanoate, and to a lesser extent glycolate, mandelate and 2-hydroxyoctadecanoate, to the corresponding 2-oxoacids, with a reduction of O2 to H2O2 . May be involved in the utilization of L-lactate as an energy source for growth (By similarity). Catalytic Activity: a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2 Sequence Mass (Da): 44229 Sequence Length: 408 EC: 1.1.3.-
C2K1F0
MVDAVKADPFGKVNAIDVLDLASLEARAEKVLGRGEFGYISEGSDDGYTMHRNTTAFQDVHMLPRVLQGVENPDQSTTFMGAKLASPLLTAPIASNTLAHPSGELGLAKGAKEAGIMMSQSTFASKTIAETAAVSDGAPYMFQLYMPKDWEYCQYLLDEAKQAGALAIILTADSTLGGYREKDVMNHYHLKGRLANLEGYNTGQSGVGAGGLFKESMQKLDLGLISKLASYSGLPIIIKGIQHPADAVAAITAGAAGIYVSNHGGRQLDGAPGAIEQLPAIAAAVDHRVPIIFDGGVQRGTHVLKALALGADLVGIGRPFSYGLALGGWQGVKDVADHLKMEINIAMQLTGCQTMADVKQMKVKTTFA
Cofactor: Binds 1 FMN per subunit. Function: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2. To a lesser extent is also able to use 2-hydroxyoctanoate as substrate . May be involved in the utilization of L-lactate as an energy source for growth (By similarity). Catalytic Activity: (S)-lactate + O2 = H2O2 + pyruvate Sequence Mass (Da): 38777 Sequence Length: 368 EC: 1.1.3.-
B1HZY7
MTNTTDGDLLLKNITAQAPFPICFADLEKAVAEKIPAGPFGYIRSGAGGEQTLRNNRSAFEKYSIVPRFLNDVSNVHTSINLFGKTYPTPLLFAPVGMNGMVHEEGELAAVRAAQQLNMPYIQSTVSTYALEDVAEAAPSATKWFQLYWSTNEEIAFSMAARAESAGFEAIVLTVDTVMLGWREEDVRNQFSPLKLGYAKGNYINDPVFMASLPNDSFESYVQGVLQNVFHPTLNWEHVRELKRRTNLPILLKGILHPEDAKLAIVNGVDGIIVSNHGGRQLDGVIGSLDALPSIVSAVKGQIPIILDSGVYRGMDALKALALGADAVAIGRPFIYGLALEGQQGVERVMTNIYDELKVSIALAGTTSIEGLRTITLVKNDGMEVK
Cofactor: Binds 1 FMN per subunit. Function: Oxidase that catalyzes the oxidation of a broad range of 2-hydroxyacids in vitro, such as (S)-lactate, 2-hydroxyoctanoate, mandelate, 2-hydroxyoctadecanoate and (S)-2-hydroxyglutarate, to the corresponding 2-oxoacids, with a reduction of O2 to H2O2 . May be involved in the utilization of L-lactate as an energy source for growth (By similarity). Catalytic Activity: a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2 Sequence Mass (Da): 41916 Sequence Length: 386 EC: 1.1.3.-
Q8Z0C8
MTAISSPINLFEYEQLAKTHLSQMAFDYYISGAGDEITLQENRAVFERIKLRPRMLVDVSQINLTTSVLGQPLQLPLLIAPMAFQCLAHTEGELATAMAAASAGTGMVLSTLSTKSLEEVAEVGSKFSPSLQWFQLYIHKDRGLTRALVERAYAAGYKALCLTVDAPVLGQRERDRRNEFVLPPGLHLANLTTISGLNIPHAPGESGLFTYFAQQLNPALTWDDLEWLQSLSPLPLVLKGILRGDDAARAVEYGAKAIVVSNHGGRQLDGAIASLDALPEIVAAVNGKAEVLLDGGIRRGTDIIKALAIGAQAVLIGRPVLWGLAVGGQAGVSHVISLLQKELNVAMALIGCSQLQDIDTSFLHL
Cofactor: Binds 1 FMN per subunit. Function: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2. In extant N2-fixing cyanobacteria such as Nostoc, this enzyme primarily serves as an O2-scavenging enzyme, protecting nitrogenase that is extremely sensitive to O2, and is therefore an essential partner in N2 fixation. Also shows clear oxidase activity with glyoxylate in vitro, and low activity with glycerate, hydroxypyruvate and glycolate. The very low glycolate oxidase activity indicates that this enzyme is unlikely to be involved in photorespiratory glycolate metabolism, a pathway that seems to exist in this cyanobacterium, but in which the oxidation of glycolate is taken over by glycolate dehydrogenase (GlcD). Is not able to use D-lactate as substrate and does not show any dehydrogenase activity with NAD(+) or NADP(+). Catalytic Activity: (S)-lactate + O2 = H2O2 + pyruvate Sequence Mass (Da): 39165 Sequence Length: 365 EC: 1.1.3.-
Q8RNT4
MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNLAGKLARRAVLTSKKLVYVWTENFANVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNFVASLPASAAAQFERIAAGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIALLTRVGLLVDDILKSASNLVTQGGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAVDKLLTGTGFAYAPIALFALGKDRAGLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMAKTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGAARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPAALPDYPYRDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATIRTRNQARRKPYEYLLPSRIPASTNI
Cofactor: Binds 1 Fe cation per subunit. Function: In presence of oxygen, converts linoleate into (9S)-hydroperoxy-10,12-octadecenoate (9HPOD), which spontaneously decomposes to the corresponding 9-hydroxy-10,12-octadecenoate (9HOD), and into 13-hydroperoxy-9,11-octadecenoate (13HPOD) which spontaneously decomposes to the corresponding 13-hydroxy-9,11-octadecenoate (13HOD). Also active on linolenate. To a lesser extent, is also able to convert oleate into (10S)-hydroperoxy-8E-octadecenoate, which spontaneously decomposes to the corresponding 10-hydroxy-8E-octadecenoate. Is almost not active on arachidonate. Catalytic Activity: (9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate Sequence Mass (Da): 74519 Sequence Length: 685 Subcellular Location: Periplasm EC: 1.13.11.12
B7RR92
MESADLRDPDGMPVTLSDFEIDAAGRLSADLLAYLEGGAEAGQSVTENRAAFGRIGLLPKLLSPCAGGHTRTTILGKQAPHPIMVAPMAFQNLFHPQGESATAMAAAAQDATMVLSCQTSTPPEDIATIPGRRWFQLYMQADHEATMALVTRAVDCGADALVVTLDAPINGLRDREVAAGFTLPDDVRPVMLDVLPQPPRPHLRDGQSVVFDGMMVFAPTADDLARLIADSPVPVIVKGCLRPADATRLIDLGAQGIIVSNHGGRVLDTVPAPITQLAAVVDAVAGAVPVYVDGGIRRGSDVFKALALGAQAVLVGRPVMHGLIVDGPRGASQVLRRLRDELEVTMALCGCATVADITPDLLTGFSGTGS
Cofactor: Binds 1 FMN per subunit. Function: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2. Is also able to use glycolate and to a lesser extent 2-hydroxyoctadecanoate as substrate. Catalytic Activity: (S)-lactate + O2 = H2O2 + pyruvate Sequence Mass (Da): 38615 Sequence Length: 370 EC: 1.1.3.-
O33655
MENKSEMINATTIEFKTSSAEGSVDFVNVFDLEKMAQKVIPKGAFGYIASGAGDTFTLHENIRSFNHKLIPHGLKGVENPSTEITFIGDKLASPIILAPVAAHKLANEQGEIASAKGVKEFGTIYTTSSYSTTDLPEISQTLGDSPHWFQFYYSKDDGINRHIMDRLKAEGVKSIVLTVDATVGGNREVDKRNGFVFPVGMPIVQEYLPNGAGKTMDYVYKATKQALSPKDVEYIAQYSGLPVYVKGPQCAEDAFRALEAGASGIWVTNHGGRQLDGGPAAFDSLQEVAESVDRRVPIVFDSGVRRGQHVFKALASGADLVALGRPVIYGLAMGGSVGTRQVFEKINDELKMVMQLAGTQTIDDVKHFKLRHNPYDSSIPFSPKCFKIRLIFRRPNQILGQFF
Cofactor: Binds 1 FMN per subunit. Function: Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2. Is likely involved in the L-lactate aerobic metabolism of S.iniae that enables the bacterium to utilize L-lactate as an energy source for growth under aerobic conditions in the absence (or at low concentrations) of glucose. Catalytic Activity: (S)-lactate + O2 = H2O2 + pyruvate Sequence Mass (Da): 44120 Sequence Length: 403 EC: 1.1.3.-
O13629
MLEAVTNPKSSLATFSKQLNGLLQAKVVVCKSVNPYFNLALENYLYENSTAKHCLLLYTNSPSVIIGRNQNPWVEANVKLCRDNFVNIIRRKSGGGTVFHDFGNLNYSVLMNREEFSHTENASIMIQALRNLGVHARLNQRHDIVLAQSQRKISGSAYKISRNRCYHHGTMLLNSDLEGVREYLRSPSTGILSKGVSSTRSPVSNTKLLKAEFIKQVISCFLLHKSHSTTTKPLSKPRASSKRLYDIEPKSVITLEQNDLLGVPSILKAVNELQSWEWTFGQTPSFKQHLESTELSVSMDISVVHGRLEKVIFSTPNATLEHELSSIPWTGLCYESGFANTFLISGIHSKEAISILKWISDSI
Function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Catalytic Activity: (R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) Sequence Mass (Da): 40652 Sequence Length: 363 Pathway: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.1.20
Q9ZU49
MTIGSFFSSLLFWRNSQDQEAQRGRMQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMESGTSTAPR
Function: Plays a general role in cellular responses to stress, may be by attenuating the signal produced by phospholipases. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities. Substrate preference is diacylglycerol pyrophosphate > phosphatidate. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 36683 Sequence Length: 327 Subcellular Location: Membrane EC: 3.1.3.-
Q5PH64
MNRTKLVLGAVILGSTLLAGCSSNAKIDQLSSDVQTLNAKVDQLSNDVNAMRSDVQAAKDDAARANQRLDNQATKYRK
Function: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. Location Topology: Lipid-anchor Sequence Mass (Da): 8391 Sequence Length: 78 Subcellular Location: Cell outer membrane
Q04396
MISVMADEKHKEYFKLYYFQYMIIGLCTILFLYSEISLVPRGQNIEFSLDDPSISKRYVPNELVGPLECLILSVGLSNMVVFWTCMFDKDLLKKNRVKRLRERPDGISNDFHFMHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSDSDSLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLWQRVFTTRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWTFTNLAKRDILPSPVSV
Function: Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA. Catalytic Activity: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate Location Topology: Multi-pass membrane protein Sequence Mass (Da): 31586 Sequence Length: 274 Domain: The phosphatase sequence motif I (including Arg-143) and II (including His-189) are part of the cytoplasmic loop 2 and phosphatase sequence motif III (including His-235) is part of the cytoplasmic loop 3. Subcellular Location: Golgi apparatus membrane EC: 3.6.1.75
P0A0V1
MKNQVKKILGMSVVAAMVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEKYSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRSISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK
Function: Could play a role in the pathogenesis of H.pylori by serving as an inflammatory mediator. Location Topology: Lipid-anchor Sequence Mass (Da): 19108 Sequence Length: 175 Subcellular Location: Cell outer membrane
Q9XI60
MPEIHLGAHTIRSHGVTVARFHMHDWLILLLLIVIEIVLNVIEPFHRFVGEDMLTDLRYPLQDNTIPFWAVPLIAVVLPFAVICVYYFIRNDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGIGIFHNVTKNVLCTGAKDVVKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDQRGHVAKLCIVILPLLVAALVGVSRVDDYWHHWQDVFGGAIIGLTVATFCYLQFFPPPYDPDGWGPHAYFQMLADSRNDVQDSAGMNHLSVRQTELESVR
Function: May play a general 'housekeeping role' in lipid metabolism. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities with no preference for either substrate. May play a role downstream of the ABA signaling pathway during seed germination and in stomatal movement in leaves. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32702 Sequence Length: 290 Subcellular Location: Membrane EC: 3.1.3.-
E8XH69
MNRTNQLILGAVVLGSTLLAGCSSNAKIDQLSSDVQTLSAKVEQLSNDVNAMRSDVQAAKDDAARANQRLDNKVFRICK
Function: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. Location Topology: Lipid-anchor Sequence Mass (Da): 8492 Sequence Length: 79 Subcellular Location: Cell outer membrane
Q8Z6K1
MNRTNKLILGAVVLGSTLLAGCSSNAKIDQLSSDVQTLSAKVDQLSNDVNAMRSDVQAAKDDAARANQRLDNKVFRICK
Function: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. Location Topology: Lipid-anchor Sequence Mass (Da): 8478 Sequence Length: 79 Subcellular Location: Cell outer membrane
Q8LFD1
MARFSFPCFPNFGGFNQAVTNRGPEISETADNWVSPSDIPLIEPNSKEHRMREAQLGGHTLRSHGMTVARTHMHDWIILVLLVILECVLLIIHPFYRFVGKDMMTDLSYPLKSNTVPIWSVPVYAMLLPLVIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLGDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAFDGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICYLQFFPPPYHTEGWGPYAYFQVLEAARVQGAANGAVQQPPPQVNNGEEEDGGFMGLHLVDNPTMRREEDVETGRG
Location Topology: Multi-pass membrane protein Sequence Mass (Da): 40775 Sequence Length: 364 Subcellular Location: Plastid EC: 3.1.3.-
Q9HVV7
MRFVNTLPLIFGLTAALGSSMALALPSDREQPIRVQADSAELDDKQGVAVYRGDVVVTQGSTKLTGNTVTLKQDKNGDIEVVTSVGKPAYYEQKPAPDKDVTKAYGLTIQYFVTQNRVVLIDQAKVIQEGNTFEGEKIVYDTQRQIVNAGRATGSQVTSPRPRIDMVIQPKKKAQ
Function: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm (By similarity). Binds LPS . Important for cell envelope stability and essential for growth, cell viability and ability to cause infection in different animal models . Sequence Mass (Da): 19126 Sequence Length: 175 Domain: Adopts the canonical beta-jellyroll structure present in E.coli Lpt proteins. Subcellular Location: Periplasm
P24693
MSELLQAQSLFKSYRRRVVVRDVSVQVATGEVVGLLGPNGAGKTTTFYMMVGLVRPDRGHIFLQQRDITALPMHERARMGLGYLPQEPSVFRQMSAADNVLAVLETLPLSPVERQERQEQLLSELHLHALRDTKGHSLSGGERRRVEIARALAMSPRFILLDEPFAGIDPISVLEIQRLIRDLRARGIGVLITDHNVRETLGICERAYILHDGKVLTAGSPQEIVDDPMVRQVYLGDQFQI
Function: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 27023 Sequence Length: 241 Subcellular Location: Cytoplasm EC: 7.5.2.-
P0A9V3
MATLTAKNLAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDDDDISLLPLHARARRGIGYLPQEASIFRRLSVYDNLMAVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVIDIKRIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQDEHVKRVYLGEDFRL
Function: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 26801 Sequence Length: 241 Subcellular Location: Cytoplasm EC: 7.5.2.-
P45073
MSILTAENLAKSYKSRKVVSDVSLTVNSNEIVGLLGPNGAGKTTTFYMVVGLVRQDQGKIVIDGEDISLLPMHNRAQRGIGYLPQEASIFRRLTVYENLMAVLEIRKDLTPQQRREKADELIEEFNISHIRDNLGQALSGGERRRVEIARALAANPKFILLDEPFAGVDPISVSDIKKIITDLRNRGLGVLITDHNVRETLDVCERAYIVGAGKIIATGTPEQVMNDEQVKRVYLGEQFKL
Function: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 26814 Sequence Length: 241 Subcellular Location: Cytoplasm EC: 7.5.2.-
P11160
IDIKRIIEHLPRQRLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPQQILEDEQVKRVYLGEDFRL
Function: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 7914 Sequence Length: 68 Subcellular Location: Cytoplasm EC: 7.5.2.-
P20162
LETRKDLDRDGRRKVLESLLQEFHISHIRDNLGMSLSGGERRRVEIARALATAPKFILLDEPFAGVDPISVGDIKQIIHHLKAKGIGVLITDHNVRETLDICETAYIVNDGRLIAEGDAETILANELVKEVYLGHEFRLXPGTRLKYWQTALKLRVKLLLYSRQTLQFKAXNLLDLALRRPRVVDGACAPANKVLSPC
Function: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity). Location Topology: Peripheral membrane protein Sequence Mass (Da): 22274 Sequence Length: 198 Subcellular Location: Cytoplasm EC: 7.5.2.-
Q8ZQZ7
MRYLVTLLLSLAVLVTAGCGWHLRSTTQVPASMKTMILDSGDPNGPLSRAVRNQLRLNNVNLLDKDTTRKDVPSLRLGTVTILQDTASVFQDGQTAEYQMVMTVNASVLIPGHDIYPISTKVYRSFFDNPQMALAKDNEQAMIVQEMYDKAAEQLIRKLTSVRAADIQATKEEATADNETAAPASTPARVSTTLSN
Function: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. Location Topology: Lipid-anchor Sequence Mass (Da): 21458 Sequence Length: 196 Subcellular Location: Cell outer membrane
Q2NUU8
MRYWTLALVLGLAVTITAGCGYHLRGTTDQVPTEMKTMTLNSYDPYGPLTRAVRAELRLNDVTLVDDAQDKNNTLPSLRIVNSSENQVTASVFQDGKTAEYQMTLGVHAQVLMPGEDYYPIDVKVYRSFFDNPLTALAKDAEGDIIRQEMRQQAAQQLVRKLLTVHAAEEADKALDAKLKQQQPPQPVAPAS
Function: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. Location Topology: Lipid-anchor Sequence Mass (Da): 21292 Sequence Length: 192 Subcellular Location: Cell outer membrane
A7FKW1
MRHRILTLLLGLAVLVTAGCGFNLRGTTQVPTELQKLLLESSDPYGPLARSIRQQLRLNNVTIVDDAMRKDIPTLRIIGSSESQETVSIFRNGVAAENQLVLHVQAQVLIPGHDIYPLQVNVFRTFFDNPLTALAKEAEAEVLRQEMREQAAQQLVRQLLTVHAAEVKNTQKNGDKPVSDANAAQGSTPTAVNETTLGEPAVSTSAK
Function: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. Location Topology: Lipid-anchor Sequence Mass (Da): 22570 Sequence Length: 207 Subcellular Location: Cell outer membrane
Q8RFU2
MVDIHSTAIIEDGAIIEDGVKIGPYCIVGKDVVIKKGTVLQSHVVVEGITEIGENNTIYSFVSIGKDNQDLKYKGEPTKTIIGNNNSIREFVTIHRGTDDRWETRIGNGNLIMAYVHVAHDVIIGDDCIFSNNVTLAGHVVIDSHAIIGGLTPIHQFTRIGSYSMIGGASAVSQDVCPFVLAAGNTVVLRGLNIVGLRRRGFSDEEISNLKKAYRILFRQGLQLKDALEELEKDFSEDKNVKYLVDFIKSSDRGIAR
Function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP] Sequence Mass (Da): 28198 Sequence Length: 257 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. Subcellular Location: Cytoplasm EC: 2.3.1.129
Q62JD7
MAFQLTPLRVALVAGEPSGDLLGASLLGGLHARLPASSRYYGIGGPRMSAVEFDAHWPMEKLAVRGYVEALKHIPEILRIRGELKRQLLAEPPDAFVGIDAPDFNFGLEQALRGAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFEPELLEKAGVAATFVGHPLADEIPLEPDTHGARIALGLPGGGPVIAVLPGSRRSEIELIGPTFFDAMELMQQREPGVRFVVPAATPALRALLQPLVDAHPSLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPDALADATLTQLRDDANRRALADIFTDMHLALRQNTAQRAAEAVAHVIDSRKPR
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP Sequence Mass (Da): 42012 Sequence Length: 388 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.4.1.182
Q9PIK8
MKTFLVCALEPSANLHLKEVLKAYKKDFGEFELHGIYDESLCKEFDLNSKPLYSSHEFSAMGFIEVLPLIFKAKKAIKELANLSFTQKINGILCIDSPAFNIPFAKALKKAGSKIPRIYYILPQVWAWKKGRIPIIESHFDILASILPFDNQFFNKSTYIGHPLLDEIKEFKNQEDINHTFSKKDDEKTIAFLPGSRRSEIRRLMPIFKELSQKFKGKKILCVPSFNLEKLEVYGDISEFKIESNTPKVLKKADFAFICSGTATLEAALVGTPFVLAYKAKAIDIFIAKLFVKLKHIGLANIFCDFAGKEALNPEFLQDKVNVLNLYEAYNKYDYKAFFAKVDFLKEYLQFGSAKNLAKILNEI
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP Sequence Mass (Da): 41581 Sequence Length: 364 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.4.1.182
B8E7Q3
MSNKTPLVFAMVAGELSGDILGAGLMAALQKNHPDARFVGIGGPRMEALGFRSLFAMEELAVMGIVEVLSRLPRLLTVRASLIKEITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFYDQHQVPCTFVGHTLADDIPFQSDKAAARALLGLDADAEYLAILPGSRGGELKQLAEPFVKAALLIRQNFPDIRFVTPLVNQKRRDQFEQALKDFAPDLEIHMIEGQSREVMAAADGILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKRMMQVERFSLPNLLAGKDLVPELIQEDCTPEKIAAAVTLELNRDFAPLKAEFEALHQVLRRDASLKAAEAVMALVEPKHTQAKSPEAN
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP Sequence Mass (Da): 43181 Sequence Length: 392 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.4.1.182
Q8EGG2
MSKKSQLVFAMVAGELSGDILGAGLMAALQKTHPNARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLHVRASLIKSITELKPDCFIGIDAPDFNIGLELKLKAQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHQVPCTFVGHTLADDIPLESDKACARQVLELDQEAEYLAILPGSRGGELKQLAEPFVKAALLIKQQFPDIRFVTPLVNQKRREQFEQALKDHAPDLEIHMVEGKSREVMAAADGILLASGTATLEAMLIKRPMVVAYRVSPLTYSIAKRMMQVNRFSLPNLLAGCDVVPELIQHDCTPEKIAAAVGVELNRDFAPIKAEFERLHQVLRCDASQKAAEAVLALVDFKEVN
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP Sequence Mass (Da): 42517 Sequence Length: 385 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.4.1.182
Q72RV5
MKEILYRRSIQDTVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEYRKGLEKASISAELSNVVDTSNATTLGDGIHKIQTVEHLLAAVYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIIEYPEIVEPIYIQSPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQSITVSLDREKIKQEILPARTFGFLKDVEALQARGLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSNVTGDEISKYKSRRIPLFKRKAVVV
Function: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Catalytic Activity: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate Sequence Mass (Da): 33088 Sequence Length: 301 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. EC: 3.5.1.108
Q2W0G6
MRQRTLKSAIGCTGVGLHSGAKVTMVLHPAEAGTGIRFRRVDIAGGGAIVPALWSSVGDTRMNTCLKNEAGVVVGTVEHLMSALAGMQIDNCLIEINGPEVPVMDGSAAPFLFLIECAGVVEQEAPRQAIKILKRVAIKDGERTASLTPSSGFSVRFEIDFGASAISRQEFFVNLTRGTFKAEVSRARTFGFEQEVAMLRAHGLARGGSLDNAVVIDSTGTKVLNDDGLRYQDEFVRHKVLDAVGDLYLAGAPLLGHYHGVRAGHAVTNQLLRALFADATAWELTTIAPGSAAAPFAAQPLAIAANG
Function: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Catalytic Activity: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate Sequence Mass (Da): 32379 Sequence Length: 307 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. EC: 3.5.1.108
Q1GZ08
MLKQRTLKKEISATGVGLHSGDKVTLTLRPAAPDTGIVFRRIDLPDTAEFKVQPHLVTDTKLCSALECNGARVATIEHLMSALAGLGIDNIRIELNAGEVPIMDGSAGPFVFLLQQAGIVEQDAMKKFIRIKKTVEYREGDKWVRFDPYFGFKLDFTIDFNHPAVEHTGQRITIDFADNSYIKEISRARTFGFMHEVEALRSMGLARGGSLDNAIVLDEFRVLNSDGLRYDDEFVKHKMLDAIGDLYVLGHPLIGAFSAYKAGHYMNNQLLRALLADGDAWEYATFAKIEEAPGAFRNPIGLPPALQYV
Function: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Catalytic Activity: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate Sequence Mass (Da): 34331 Sequence Length: 309 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. EC: 3.5.1.108
F4JGP6
MANSLRTLFSVSTHGVFLNKRSSYRVRKVFVGMPLRICSEIPRFVSVSCIRSDMCGIMMLGKDVHDLLETSSGGNVEKGFLRWRNGGGMYHRSALIDSSALVEFGAVVHQEAILGAEVHIGSNTVIGSSVKIGPSTKIGNCSIGDLCVIHNGVCIGQDGFGFYVDDNGNMVKKPQTLNVKIGNRVEIGANTCIDRGSWRDTVIGDDTKIDNLVQIGHNVIIGKCCLFCGQVGIAGSAEIGDFVALGGRVAVRDHVSIVSKVRLAANSCVTKNITEPGDYGGFPAYKKTEPDSAFASDKHCFILQKILIQVPIHQWRRQIVEAQISSKRKP
Function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 35708 Sequence Length: 330 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. Subcellular Location: Mitochondrion EC: 2.3.1.191
Q14JF8
MQYTLKQISEHLNAKVINEPSGEVIITGLTYAEQAKENDLTLIDKQEHIKLWQNSKATAAIVSKKISKELAQVNDKPLIVVNNADLAMAKILELFSVPYPEQNGIHEKAIIDPTAKIGKNVSIGPSAYIGKNVEIGDNTIIYANVCIYNDAKVGTNCIIWPSVIIRDRTIIGHFCRLCSNCSIGSDGFGYRPSEDGRTIVRIPHIGNVVIGSFVDIGSNTCINNAKYGSTIIGDYTKIDNLVQIGHNVIIGKGCMICGQAGISGSVTIGDGVIIAGNAGIKDHTNIGSDARIGGKAGVMWDVPAGESHMGYPAYKDSELAKQWIAIRKLPETMKKLKAIAKSLNIDL
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 37384 Sequence Length: 347 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q7NJG8
MGVQFSAAELTDLVGGELSGDPGRLVVGARPPEEAEGGDLTFALDLHARKLIETTRAGVAITPVRWPFEHLTQIVVANPRLAMAQVLAHMFPQPIAMPPAGIHPSAVVHPSAVVHPSASVAALVYVGPRAAVGANTHLFPGVYVGAEAVVGSECLIYPNVVLMDGIRLGDRVVIHAGSVLGSDGYGFVPTGERHLKVPQVGTVVIGDDVEVGANVAVDRATMGQTEIQAGTKIDNLVHIGHNDRIGRHCLIVSQVGLAGSVKVGDRTVIAGQAGVANQTTVGADCLVLARSGVTKDLPDHSKVSGFPAQDHLLELKQQAARSRLPQIVEQMRQMQRRIEQLEVQLLGRL
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 36734 Sequence Length: 349 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q5X0C0
MNSSLRDIANLVQGMVIGNDAITVSTLSPIDNILPGSLVFAEGEDNIKLAENSEAAAILIGQGTIDSPKPLIQVKNPFKAFIALLNHFYPPRRISPGVHPTAVIGAEVQLGDEVYVGPFVVIESGSIIGNHSVLKSHIHIGHNVVIGDHTTIHPQVTIYDNCRIGSNVTIHASTVIGSDGFGYTFVDGQHLKVPHSGYVVIENNVEIGANTAIDKATLGATVVGEGTKIDNLVQIAHSVKLGKHNIICAFTGIAGSTTTGNNVIFAANVGVSDHVHIEDEVILGARTGVPPHKHLKKGTVYLGNPAKPKDVAIKHELSVNRIPLIRKNIKSLTEQVAVINKKLDIKAKEVE
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 37285 Sequence Length: 351 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q30RG5
MNLKDIAKIINSDFSGEYFEITKMNTLRDATKSEISFVANAKYIKEIQNSNAGAIIVSKDTKEFVPSGCVALVVENPYWEMATLSKYFAPSIEDETLPEPKIGEGTTISPRAEIARGAIIGKGCTIMAHVYIGTNAVIGDNTIIYPSVTVYRDCRVGSECIIHANTTIGSDGFGFATNKQGEHRKIYQNGNVEIEDNVEIGSSTTIDRAVFGTTLIKYGVRIDNLVQVGHNCVIGEHSVLVAQAGISGSTTMGRNVVMGGQSATAGHLSIAPFTTMAARSGVTKSIDKSGLTFAGFPLLEHRLWLKLQAKIARLIKQN
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 34282 Sequence Length: 318 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
F4JIP6
MAATLWRLYSKSICNSLQGIILNKPFIQKQLLLSSRTRSLSFSSDSQFGSATAEVCSNTGLKTGGGIIVKEGFLRWENGGGTCHSSAQIYSSALVEFGAVVHEKAVLGAEVHVGSGTVIGPSVDIGPSTRIGYNVSISNCSIGDSCVIHNGVCIGQDGFGFYVDEHGNMVKKPQTLNVKIGNRVEIGANTCIDRGSWRETVIEDDTKIDNLVQIGHNVIIGKCCLLCGQVGIAGSVTIGDYVALGGRAAVRDHVSIVSKVRLAANSCVTRNITEPGDFGGFPAVPIHEWRKQIVRAQIANKREI
Function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 32331 Sequence Length: 304 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. Subcellular Location: Mitochondrion EC: 2.3.1.-
Q14G52
MYSLDFLASKLDGEVKGDKNVEIKKIATLSQAGEGDISFCTNPKYLKALSETKASAVLITEEVLEFCNTNAVVLSNPYMALAKVMELFDKSPRPDGKIHSKAVIAASAIIGENVTIGANAVVGENVVIGDNVYIGACATIDNGTKIGNDTLIKSNVSIAHDVVIGTGCIIHQNAVIGCDGFGNARDEDGSWTKIPQLGRVIIEDDVEIGSGTTVDRGAIDDTIIKKGARIDNLVQIAHNVVIGRNTALAGVTAVAGSTTIGDNCLIGGQSAITGHISICDNTIIGGASNIGKSITKPGMYYAAFEAKPRIQWGRFVAKLAKIDTLITKVKQLEEKIK
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 35443 Sequence Length: 337 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q7NJ21
MKLSDISAKLGCALEGDGQVDIVGIAGIEEAEAGHLTFLSNPKYKAKLRHTKASAAIVPADFEASAAWPLPLLRHANPYLTFAHAIELFYSPPPAPHGVHPTAVVAPTAVCGHNVRIGASSVIGEGVVLADGVTVYPNCTIYPGVRIGRNSTIHSNCVVREHVVIGEDCIVQNGAVIGADGFGYAKQADGTWYKIVQSGSVVLENRVEIGACTTVDRATIGETRIKSGSKLDNLVMIGHGSSVGENTLLCGQVGLAGSSTVGRNVMLAGQVGVAGHLHIGDNVVATVKSCIWKSVEANQVLYGNIPASDSHTWLKASAVFRQLPHMQKSVQQMQKRIAVLEEPFKTNGKSGQADAPPKVALECHGTTGDAPQG
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 39027 Sequence Length: 373 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q1H149
MNKSYSLREIVSTLGGELLGKDDVLISRVASLANAQPGQISFLTDSKYRSVLATTNASAVILTPQNRDITALPRILTDNPYAYFAKVSDLLNPKPEYVAGVDDTAVIAPSAQVPASCTIMAKAVVGANVVLGEHVVVHPGCVIGEGVEIGAHSVLHANVTIYHHCMIGERCNIFSGSVIGGDGFGYAPEEGRWVKIPQVGRVVIEHDVDIGANTTIDRGAIDDTIIHEGCKIDNLVQIGHNCRIGAHSVIAGCVGIAGSAVLGKHCRIGGAAMILGHLEIADGVTVSPGSMITRSLMKAGTYTALMPFQSHDEWLRTAAGIRRLGELAERVKQLEKQLAPQQVSGIQRDK
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 37051 Sequence Length: 350 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
B3E0P9
MISYSVKQLASLVGGIVEGEPEIEITGISDILDAKKGQITFLSNPRYEAAVEKTQASAIVVSKSYKSSSPITLIRVDSPSLAFSQIISLFSPQPFSYEPGIHPTALIGREVEIGKEVSIQPYAVIEDKVKIGDGCVIGAYVFIGRESIIGEKSFFYPHVTIRERSRIGKRVILHPGAVIGSDGFGYEQTNGRHEKIPQVGIVQIDDDVEIGANTTVDRGRFGKTWIQEGCKIDNLVQIAHNVIIGKNSIIAAQTGISGSTSLGEHVTLAGQVGIAGHIHIGDGATITAQSGVTKDVPPRAVLSGRHARPINLTHKLEVLYNKLPELWERLKKLEKKYDGDSPRPEADPYNS
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 37997 Sequence Length: 351 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
B8INJ6
MSDPVFFSSVGPILLAEVAALAGAALPEGLDRELAIRGAAPLESAGPDDLAYMDNAKYAEALGLTRARACLVSPRFAARVPEGTIALVTPQPYRGFAKVLARLFPSAARPTSLFGATGVSPGSFVHPAARLEPGVVVDPGVVIGPGAEIGAETVLAAGAVIGPGTRIGRGCAVGPGASVLHALIGNRVIIHGGARIGQDGFGFAMGAGGHLKVPQVGRVIIQDDVEIGANTTIDRGASRDTIIGEGTKIDNLVQIAHNVVIGRHCVIVAQVGISGSTTLEDYVVLGGQVGVVGHLRIGMGAQIAGSSNINKDVPPGARWGGTPAKPVREWFREMTTLKRIAARERLAEDTAE
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 36034 Sequence Length: 352 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q1D385
MPRQLGELAAHVGGELLGDPSQLIHGLNGLEEAGPGDVSFYGNPRYRRQFEATRASAVLVGADVPPREGVALVRVANPHLAYAKLLRLFHAPERPAAGVRPGAWVHPEATVHPEAVLLPGASVDRGGRVGARTVLYPGAYVGEQAEVGEDCVLYPNVTVRERCIVGARVILHASSVVGADGFGFAFNPEGEAGPEHFKIPQVGIVRIEDDVEVGACTCIDRATVGETVVGRGAKLDNLVQIAHNVRVGPLSLICAQAGVSGSAEVGTGVVLAGQVGVVGHIRVGDLAKVGAQSGVAHDVPDGQVVSGSPAVPHREWLRASAAAGQMADLLKEVRALRRRVETLEKEKGP
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 36382 Sequence Length: 349 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
P95377
MIPATYTLSQITARLGGEWRGEDISVTAVRPLADAQAEHISFLANPKYKAEVHDSSAGAVIVSAKAADGFEGRNLIVADDPYLYFAKVARLFSPVVKARGGIHPTAVVEPGATVPTSCEIGANVYIGANTVLGEGCRILANAVVQHDCKLGDEVVLHPNAVVYYGCTLGRRVEIHSGAVIGADGFGLAFADDSWFKIPQTGAVTLGDDVEIGSNTNIDRGAMSDTTVGNGTKIDNQVQIGHNCKIGSHTVIAAKTGISGSVTIGSYCIIGGGVGTVGHIEIADKTTIGGGTSVTHSITESGKHLAGIFPMSTHKEWARNAVYIHRLSEMNKRLKTLEQQLSDAGQDSK
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 36449 Sequence Length: 348 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q3JEI7
MEIRLSEIAQFLGCAIEGDGEAPIRGIAPLHQAQASELSFYTNRKYAAQARLSKAGAIIVGAKDREQFAGRRLLISDNPYRDFARVVDRWFNRSYRPAPGVHPTAIVGDDVQIAENCSIGAYCVIEDGVTIKAHTVLFPFCYVGAKTILGEHCLLYPRVTLLERVRIGHRVILHPGVVIGGDGFGFAPDPPQGYFKVPQVGWVEIADDVEVQCNTAIDRGALGPTRIGQGSKIDNLVQVGHNVEIGEHSIIVSQVGISGSSKIGNWVTLAGQVGLVGHIRIGDGAVITAQSGVAKDVPPKAIMTGSPVQPMMENRRALAELNRLRELRKKVRELERRLTVLEQVESC
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 37696 Sequence Length: 347 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
Q312H3
MKVSDIAGALGLKLKGPDREISGVNTLEAAGPEEISFLANPKYIPMLAGTRAAAVIVSEEYAGQVETALISANPYFDFGRTLHLFARPQGSFSGISDMAYIHPEAEIGGGCTIYPHVYIGARARIGEGTTLFPGCYVGEDCAVGENCLLYPNVTLMAATTVGDDCVLHSGVVLGADGFGFARTEYGIQKIPQIGRVHVGNDVEIGANTAIDRAVLGVTTIGDGTKMDNLVQVGHNVTIGNDCLIVAQVGISGSTHVGDRVTMAGQVGVAGHLTIGDDVTVGPKSGIARSIEPGKTMGGQPAVERDVYMRTLTVMPKLPDMYKRLRKLEKELEALKGESGRDS
Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] Sequence Mass (Da): 35906 Sequence Length: 342 Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. EC: 2.3.1.191
C5B8V8
MATLFIADLHLSQQEPAITAGFLRFLAEEAPKAEALYILGDFFDYWIGDDDPQPLHRQVAGALRQLSDNGVPCYFICGNRDFLLGKSYAKRCGMTLLPDEQIITLYGQPILLLHGDTLCSDDRDYQRYRRRVHNPLLQWLFRRLPLRLRLKIAVGMRQQSQRSNSAKAMTIMDVNQETVCATLRRHGVQRMIHGHTHRPALHHFSLDDGRCALRAVLGAWHTHGSMIRVDAQGIHLIELPAHPAEDEIITTRLRSANLV
Cofactor: Binds 2 Mn(2+) ions per subunit in a binuclear metal center. Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP Location Topology: Peripheral membrane protein Sequence Mass (Da): 29503 Sequence Length: 259 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6. Subcellular Location: Cell inner membrane EC: 3.6.1.54
P44046
MKHSYFISDLHLSETQPELTALFVDFMQNLAPQAERLYILGDLFDFWIGDDEQSALIQQVKDLIKFVSDQGVQCYFQHGNRDFLIGERFSKETGAQLLPDYQLITLYDKKILLCHGDTLCIDDEAYQQFRRRVHQKWLQRLFLCLPLKVRVIIAEKIRAKSNQDKQAKSQEIMDVNQAFTAEKVQEFGVNLLIHGHTHREAIHQQEEFTRIVLGDWRKNYASILKMDESGEFGFIKD
Cofactor: Binds 2 Mn(2+) ions per subunit in a binuclear metal center . May bind a third metal with significantly weaker affinity that might facilitate the catalysis but only binds LpxH in the presence of the substrate . Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP Location Topology: Peripheral membrane protein Sequence Mass (Da): 27786 Sequence Length: 237 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6. Subcellular Location: Cell inner membrane EC: 3.6.1.54
Q2SK43
MPTLFISDLHLEIEKPDLTRFFFNFLDKVAPNAEALYILGDFFEVWVGDDEQSPLQVEVAQRLHKLAEAGTHIHLMHGNRDFLIGETYAKQCGATLLAEPHALDLYGVPSLLMHGDSLCTLDAAYQKARATFRNPAFQSQFLSRPLDQRQLTARQMRQISMAKNQGKAEVIMDVAPDEVINTFNTYGIELLIHGHTHRPDTHRYNLPQGEVKRIVLGDWGEETWYGRADADGFQLLNLKAEDIA
Cofactor: Binds 2 Mn(2+) ions per subunit in a binuclear metal center. Function: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Catalytic Activity: H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP Location Topology: Peripheral membrane protein Sequence Mass (Da): 27659 Sequence Length: 244 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6. Subcellular Location: Cell inner membrane EC: 3.6.1.54
P27300
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAPVAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARDVEIVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGHPPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDEPAKLLTQLTLLASGN
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli) Sequence Mass (Da): 35589 Sequence Length: 328 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. EC: 2.7.1.130
C5BAE1
MIARIWSGRSPLYLLLLPLSWLYGLVALLRRQAYRRGWIRVWRAPLPLVVVGNLTAGGNGKTPLVIWLVEQLQRRGYRVGVVSRGYGGRATCYPLVLGPDTRSVECGDEPLLIAQRTGARVAVAPQRSAAVQALLAQEPLDVVITDDGLQHYALARDMELVVIDGERRFGNGWWLPAGPMRERAARLCSVDAVIVNGGLPRTGEIPMALTGHTLVNLRSGERRVAGQFVTPVVAMAGIGHPPRFFHTLTQLGIPLQATHAFADHQAYQAQVLAALTPQAQPLLMTEKDAVKCRAFAQDNWWYLPVSATLPAEAGDRLLARIAALVAAQPRG
Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). Catalytic Activity: a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+) Sequence Mass (Da): 36113 Sequence Length: 331 Pathway: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. EC: 2.7.1.130