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Q03393
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. PTM: Phosphorylation of Ser-19 is required for maximal enzyme activity. Catalytic Activity: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate Sequence Mass (Da): 16386 Sequence Length: 145 Pathway: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. EC: 4.2.3.12
Q9R1Z7
MSAAGDLRRRARLSRLVSFSASHRLHSPSLSDEENLRVFGKCNNPNGHGHNYKVVVTVHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADAVSTTENVAVYIWESLQKLLPVGALYKVKVFETDNNIVVYKGE
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. PTM: Phosphorylation of Ser-18 is required for maximal enzyme activity. Catalytic Activity: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate Sequence Mass (Da): 16188 Sequence Length: 144 Pathway: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. EC: 4.2.3.12
Q90W95
MAESSGNPPAERIGYITRVQSFSACHRLHSLRLSDEENKEVYGKCNNPYGHGHNYKVEVTVRGKIDPVTGMVMNLTDLKKCIEEVIMIPLDHKNLDKDVPYFADVVSTTENLAVYIWDNMAKALPASLPYEIRIHETDKNIVVYRGE
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Catalytic Activity: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate Sequence Mass (Da): 16679 Sequence Length: 147 Pathway: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. EC: 4.2.3.12
P80081
AQADATANEVAERIGYITRVQSFCASHRLHSPTLVMNITNIKEHIEEVIPLDHKNLDKDVPYFANVNVAVYIXDNMVKQLPANLLYEVKIHETDKNIVVYRGE
Cofactor: Binds 1 zinc ion per subunit. Function: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Catalytic Activity: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate Sequence Mass (Da): 11729 Sequence Length: 103 Pathway: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. EC: 4.2.3.12
O52787
MQFKNILVVCIGNICRSPMAEYLLKQNYPQLTIHSAGISGMIGYSADEKAQLCMERIGIDMSPHIAKKLNAELLKQADLILVMSQNQQKHIEQTWPFAKGKTFRLGHWQGKNIPDPYQHDQAFFDETSLLIQTCVADWTKHI
Function: Dephosphorylates ptk. May be involved in the production and the transport of exopolysaccharides. Catalytic Activity: H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Sequence Mass (Da): 16215 Sequence Length: 142 Pathway: Glycan metabolism; exopolysaccharide biosynthesis. EC: 3.1.3.48
P24656
MFPARWHNYLQCGQVIKDSNLICFKTPLRPELFAYVTSEEDVWTAEQIVKQNPSIGAIIDLTNTSKYYDGVHFLRAGLLYKKIQVPGQTLPPESIVQEFIDTVKEFTEKCPGMLVGVHCTHGINRTGYMVCRYLMHTLGIAPQEAIDRFEKARGHKIERQNYVQDLLI
Function: Plays a role in the regulation and processing of late viral mRNAs by displaying RNA 5'-triphosphatase and diphosphatase activities. Catalytic Activity: H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Sequence Mass (Da): 19288 Sequence Length: 168 EC: 3.1.3.48
Q7MUW6
MKKTIFQQLFLSVCALTVALPCSAQSPETSGKEFTLEQLMPGGKEFYNFYPEYVVGLQWMGDNYVFIEGDDLVFNKANGKSAQTTRFSAADLNALMPEGCKFQTTDAFPSFRTLDAGRGLVVLFTQGGLVGFDMLARKVTYLFDTNEETASLDFSPVGDRVAYVRNHNLYIARGGKLGEGMSRAIAVTIDGTETLVYGQAVHQREFGIEKGTFWSPKGSCLAFYRMDQSMVKPTPIVDYHPLEAESKPLYYPMAGTPSHHVTVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGRFVRTLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEWEVTNFAGFDPKGTRLYFESTEASPLERHFYCIDIKGGKTKDLTPESGMHRTQLSPDGSAIIDIFQSPTVPRKVTVTNIGKGSHTLLEAKNPDTGYAMPEIRTGTIMAADGQTPLYYKLTMPLHFDPAKKYPVIVYVYGGPHAQLVTKTWRSSVGGWDIYMAQKGYAVFTVDSRGSANRGAAFEQVIHRRLGQTEMADQMCGVDFLKSQSWVDADRIGVHGWSYGGFMTTNLMLTHGDVFKVGVAGGPVIDWNRYEIMYGERYFDAPQENPEGYDAANLLKRAGDLKGRLMLIHGAIDPVVVWQHSLLFLDACVKARTYPDYYVYPSHEHNVMGPDRVHLYETITRYFTDHL
Function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position. PTM: The N-terminus is blocked. Catalytic Activity: Hydrolysis of Xaa-Xaa-Pro-|-Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline. Sequence Mass (Da): 82266 Sequence Length: 732 EC: 3.4.14.12
P69793
MMDLDNIPDTQTEAEELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDAGEGKMKVSLVLVHAQDHLMTSMLARELITELIELHEKLKA
Cofactor: Can also use copper and nickel with lower efficiency. Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2). Sequence Mass (Da): 12748 Sequence Length: 116 Domain: The PTS EIIA type-3 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-3 domain. Subcellular Location: Cytoplasm
P69830
MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQNADVVLLGPQIAYMLPEIQRLLPNKPVEVIDSLLYGKVDGLGVLKAAVAAIKKAAAN
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2). Catalytic Activity: N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein] Sequence Mass (Da): 11427 Sequence Length: 106 Domain: The PTS EIIB type-3 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-3 domain. Subcellular Location: Cytoplasm
P30335
MPITDLVAPEAILPALKVNSKKQALQELAAKAAELTGQNERAVFEVLLQREKLGTTAVGYGVAIPHGKLPKLEKIFGLFARLDRPIDFESMDGQPVDLVFLLLAPEGAGADHLKALARIARLLRDQDIAKKLRASRDAQAIYSVLALPPATAA
Function: Seems to have a role in regulating nitrogen assimilation. Sequence Mass (Da): 16455 Sequence Length: 153 Domain: The EIIA domain is phosphorylated by phospho-NPr on a histidyl residue. Subcellular Location: Cytoplasm
P69829
MTNNDTTLQLSSVLNRECTRSRVHCQSKKRALEIISELAAKQLSLPPQVVFEAILTREKMGSTGIGNGIAIPHGKLEEDTLRAVGVFVQLETPIAFDAIDNQPVDLLFALLVPADQTKTHLHTLSLVAKRLADKTICRRLRAAQSDEELYQIITDTEGTPDEA
Function: Seems to have a role in regulating nitrogen assimilation. Sequence Mass (Da): 17960 Sequence Length: 163 Domain: The EIIA domain is phosphorylated by phospho-NPr on a histidyl residue. Subcellular Location: Cytoplasm
Q9HVV4
MIRLEQILTPGRSLVNVPGGSKKRVLEQIANLVARELPEFDAQTIFENLVAREKLGSTGFGNGIAIPHCRLSGCQSPISAVLHLDAPVDFDALDGAPVDLLFVLLVPEAATEEHLELLRQIAAMLDRADVRDRLRSAPTAEALYQIVVDVQNGQ
Function: Seems to have a role in regulating nitrogen assimilation. Sequence Mass (Da): 16730 Sequence Length: 154 Domain: The PTS EIIA type-2 domain may serve a regulatory function, through its phosphorylation activity. Subcellular Location: Cytoplasm
P33670
MIRLETILTPGRSLVNVPGGSKKRALEKVATVIADQVPELEMQDVFEKLVAREKLGSTGFGNGIAIPHCRLEGSSAPVSALLHLEAPID
Function: Seems to have a role in regulating nitrogen assimilation. Sequence Mass (Da): 9488 Sequence Length: 89 Domain: The PTS EIIA type-2 domain may serve a regulatory function, through its phosphorylation activity. Subcellular Location: Cytoplasm
Q00576
MASCVGSRTLSKDDVNYRMHFRMINEQQVEDITIDFFYRPHTITLLSFTIVSLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADIMEYAVNCHVITWERIVSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGVYLFMIIWQLTELNTFFLKHIFVFQASHPLSWCRILFIGCITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVVFWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTPEISWHHGKGSKGSEDSPPKHSSNNESHSSRRRNRHSKSKVTNGVGKK
Function: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine . Catalyzes mainly the conversion of phosphatidylcholine . Also converts, in vitro and to a lesser extent, phosphatidylethanolamine . Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55350 Sequence Length: 471 Pathway: Phospholipid metabolism; phosphatidylserine biosynthesis. Subcellular Location: Endoplasmic reticulum membrane EC: 2.7.8.29
P31452
MLSQIQRFGGAMFTPVLLFPFAGIVVGLAILLQNPMFVGESLTDPNSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLAKQAQGRACLAVMVSFLTWNYFINAMGMTWGSYFGVDFTQDAVAGSGLTMMAGIKTLDTSIIGAIIISGIVTALHNRLFDKKLPVFLGIFQGTSYVVIIAFLVMIPCAWLTLLGWPKVQMGIESLQAFLRSAGALGVWVYTFLERILIPTGLHHFIYGQFIFGPAAVEGGIQMYWAQHLQEFSLSAEPLKSLFPEGGFALHGNSKIFGAVGISLAMYFTAAPENRVKVAGLLIPATLTAMLVGITEPLEFTFLFISPLLFAVHAVLAASMSTVMYLFGVVGNMGGGLID
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This operon may be cryptic in wild-type K12 strains (Probable). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 39692 Sequence Length: 368 Domain: The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. Subcellular Location: Cell inner membrane
O69053
MSSHYDVQALPAEQREHILRGFGLGWWRQLGQVAIVFGVVLLACWYVGLLDATTLLNGLPSIATLAGEAMPPDFSGYRSWIRPLIDTLAMSIAGTAIAVVFSLVVAFVAARNTAPHPLVFGVARVLLNALRSVPELIMGIIFVAAVGFGALPGVLALGLHSVGMVGKFFAEAIEHVDEAPVEAARAAGATPMQVLLHAVLPQVTPQFADVAIYRWEYNFRASTVMGMVGAGGIGFELMGSLRIMQYQEVAAILLVILAMVTLVDAFSGVLRKHFK
Function: Probably forms part of a binding-protein-dependent phosphite transporter. Probably responsible for the translocation of the substrate across the membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 29396 Sequence Length: 275 Subcellular Location: Cell inner membrane
O69054
MLPKLVITHRVHDEILQLLAPHCELMTNQTDSTLTREEILRRCRDAQAMMAFMPDRVDADFLQACPELRVVGCALKGFDNFDVDACTARGVWLTFVPDLLTVPTAELAIGLAVGLGRHLRAADAFVRSGEFQGWQPQFYGTGLDNATVGILGMGAIGLAMADRLQGWGATLQYHEAKALDTQTEQRLGLRQVACSELFASSDFILLALPLNADTQHLVNAELLALVRPGALLVNPCRGSVVDEAAVLAALERGQLGGYAADVFEMEDWARADRPRLIDPALLAHPNTLFTPHIGSAVRAVRLEIERCAAQNIIQVLAGARPINAANRLPKAEPAAC
Function: Catalyzes phosphite (phosphonate) oxidation. Catalytic Activity: H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate Sequence Mass (Da): 36415 Sequence Length: 336 EC: 1.20.1.1
Q6CSN3
MYQLLFQRLGVTLTAGNDKKTSIPSNQLVGHLIGLILLCDDLNEAFADFQALLQNGIAISSSDRGYLVFDAHVTDCGCHLRAQMIQDVFSYFKNHEVTKLYIFDAVAKKLNELKRHCISLIQTLCWENTSAQKLGFPKNIKSYEELLKLLQWDTADISSAIADSFPMNPNNADQNEKGLVWNVTKLEVVLEFLYCSHFLSKNKIYNKKENLDSVTIDFNNAFEKRQLLSNKFHCQGTGKLGVGCRYLKHAKQSKNSFISVVSNLQSRLALLSIAFLKSRCTLPCDIEALQKNSPRNVSAIPNFLHFLILEREWSQNETPILLAVRKLHEHEHCDLYFEARINPHTFEWTLQHKECCEFEHHTPYIVITALATGSSTTKTAQLLAWELMKAQKNFRQFWLTFMSQHRQYPFEIEHDEDQLLETQVSQDIFELYCQSKREDRNQILFDDSTSLLPKHIFTEYPSIFFNFQKNVCSKHGALVI
Function: Probable cyclodipeptide synthase; part of the PUL gene cluster that mediates the formation of pulcherrimin, a red iron-containing pigment composed of two cyclized and modified leucine molecules that acts as a siderophore, a chelator that binds iron outside the cell for subsequent uptake . Two leucine molecules are cyclized via a cyclodipeptide synthase, and the resulting diketopiperazine is oxidized by a cytochrome P450 monooxygenase to generate pulcherriminic acid (PA), which can then spontaneously bind iron to form pulcherrimin . The probable cyclodipeptide synthase PUL1 and the cytochrome P450 monooxygenase PUL2 encode the enzymes responsible for the two-step pulcherrimin biosynthesis pathway (Probable). Sequence Mass (Da): 55417 Sequence Length: 480 Pathway: Siderophore biosynthesis. EC: 6.-.-.-
Q6CSN2
MLADILIPLIKKNWMAFVYFTPVLFVVLYLLKEWRAAYGFNNLGQTVAAPFGYERKTLPYNKENCARTKFLDGKSLSIKNRDQCGDLYLQRSGTYKEIVLTTPKQLMEYYKSNSKNHSKLDSFGAGAFLVALLGECLGFQNGSEWLSMRKVFDSFFTHKAAVENFPVMIDYISEWIKDLDTEQISDIDPLQLVSDLPFTCIAKYLYGSELCSKQFLQALKDLIPMHTELMHYSFLTVAGRFKIFQYFPSKKMKQVSQFQRQFIDLSLKQVELSRQSGQETVVEKLYRHVESGKFTFNNWIQTIDEILFANIEVTSTVMAWALVEMGSNIEEQNRLRCEILKVKEQSSKDDFNKETDPMQRYMKLTDTYLQYCVWETLRMHPLLWFSFPEISSETLFIDGIRISPNTPIVVDQYQINYNSPIWNPSDKPKDFGKKFAPSRFENITLRDALYSQVTFGAGSRKCLGRNFAELLIKSELAYILSKYKVTLTEKVEFSKDTFVVQPKTKIQLTAL
Function: Cytochrome P450 monooxygenase; part of the PUL gene cluster that mediates the formation of pulcherrimin, a red iron-containing pigment composed of two cyclized and modified leucine molecules that acts as a siderophore, a chelator that binds iron outside the cell for subsequent uptake . Two leucine molecules are cyclized via a cyclodipeptide synthase, and the resulting diketopiperazine is oxidized by a cytochrome P450 monooxygenase to generate pulcherriminic acid (PA), which can then spontaneously bind iron to form pulcherrimin . The probable cyclodipeptide synthase PUL1 and the cytochrome P450 monooxygenase PUL2 encode the enzymes responsible for the two-step pulcherrimin biosynthesis pathway (Probable). Location Topology: Single-pass membrane protein Sequence Mass (Da): 59318 Sequence Length: 511 Pathway: Siderophore biosynthesis. Subcellular Location: Membrane EC: 1.-.-.-
Q6CSN0
MKLTDSQKHLYSQYLAVTLIAVQFSFDTCVYLSSVVQYVKECGSDDPENYLFILQAVSAAVQVFFSFIIGDIASYVGSIKWVIIFLYFLSFVGNFLYSCAGAVSLNTLLGGRIICGAASSSGAVVYSYITAISKDRTTIFKLFSIYRTSAGICMALAQLVAILFALCDFTVRGYRITSYNAPTFASSFIILLICVLLMFVLENPPVKSARNPKNYLDAWKKFFSAGSNRLIASLILLWNMFLSTFFMCEVLYFMPIFLTLNVGWKTEYEGVAFMVSAVLGVAGSFFAPDLVKLFAKLNTPSTQDETDTSDNDKIEKEESEQKSDINTLHRNQVSLTIFALFVALIGQAFMIGASEALSNDKLPKTNSGIFFTAGLSITMLGYNFMGSSVPALFSMYIDPQVKVQLMPFIGAIAGVGKLVAPIVLAALYKTPLGLPIGVGFGMILVGISIPSLVYLRRNKM
Function: MFS-type transporer required for the uptake of iron via the uptake of the siderophore pulcherrimin-iron complex. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 50444 Sequence Length: 460 Subcellular Location: Cell membrane
Q8GTR4
MALTLTPTSSVHLLSSISVARPRIFAADFNLRSRWRRRRPVTSISNFRLRLPSKTSLHCLCSSSSASSPMSLEVSSPNSQFLDCLIYSRAYWVTQGVIAWNVDVGEGSCYFYASKSAGLSFSEDGIDGYDLRIKLEAESGSLPADVIEKFPHIRNYKSFKVPKDLDIRDLVKSQLAVVCFDAEGRLIQGTGLQLPGVLDELFSYDGPLGAHFTPEGVSLHLWAPTAQAVSVCIYKNPLDKSPMEICPLKEANGVWSTEGACSWGGCYYVYKVSVYHPSTMKLETCYANDPYARGLSADGRKTFLVNLDSDDLKPEGWDNLADKKPCLRSFSDISIYELHVRDFSANDETVEPENRGGYLAFTSKDSAGVKHLQKLVDAGLTHLHLLPTFQFGDVDDEKENWKSVDTSLLEGLRPDSTEAQARITEIQNDDGYNWGYNPVLWGVPKGSYASDPTGPCRIIEFRKMVQALNCTGLNVVLDVVYNHLHASGPHDKESVLDKIVPGYYLRRNSDGFIENSTCVNNTASEHYMVDRLIRDDLLNWVVNYKVDGFRFDLMGHIMKATIVNAKSAIGSLRKETDGVDGSRIYLYGEGWNFGEVAENGRGINASQFNLGGTGIGSFNDRIRDATLGGSPFGHPLQQGFITGLLLQPNAHDHGSEATQELMLSTAKNHIQTGMAANLKDYMLTNHEGKEVKGSEVLMHDATPVAYASLPTETINYVSAHDNETLFDIISLKTPMEISVDERCRINHLASSMIALSQGIPFFHAGDEILRSKSLDRDSYNSGDWFNRLDFSYSSNNWGVGLPPKGKNEHNWPLIKPRLQDPSFKPKSSHIVATLHNFLDLLRIRYSSPLFRLDTARAIQERVRFHNTGPSSIPGAIVMSIEDGHRGIPSVSQIDPIYSLIVVIFNARPSEFSYPSPALKDRKLELHPVQVMSADEIVKKSVYDSFSGGFTVPARTTTVFVESRNG
Function: Involved in starch degradation and also probably in the trimming of pre-amylopectin chains during starch synthesis. Catalytic Activity: Hydrolysis of (1->6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan. Sequence Mass (Da): 107067 Sequence Length: 965 Pathway: Glycan biosynthesis; starch biosynthesis. Subcellular Location: Plastid EC: 3.2.1.142
P20440
MRNFILFPMMAVVLLSGCQQNRPTTLSPAVSGQAQLEQLASVAAGARYLKNKCNRSDLPADEAINRAAINVGKKRGWANIDANLLSQRSAQLYQQLQQDSTPEATKCSQFNRQLAPFIDSLRDNK
Function: Involved in the secretion of pullulanase. Location Topology: Lipid-anchor Sequence Mass (Da): 13808 Sequence Length: 125 Subcellular Location: Cell outer membrane
Q9LP21
MEIFNFGQASDHRRLPDFGSGGFLQSLDTNPFLKNQYYNNSVEALELCKKLNKMGISCDMSIWTKPEEPFRVDPGDFGAKTLHESFGFDQNLTGASQIHDGFRNFSSVRVQNNNFHGVSPSPGLLGLQDSFNPNGFEEMMAFKDHKDFLLDHINEPIKRSPFLRGNDAFKGSLMFEGIRVSQILAAMEGSGASYPDEPKINGGLPLDLVSMVEIYGSVNLMARDQIGCRALQKLVEEGTVLDSKVIFLEIIDHVVELSMDPLGNYIVQKLLVVSDEEQRTMIVSVLTSKPRELIKICLNTNGTRVIQKMIKTVKTKQQIALVKSALEPGFLVLVNDSNGYHVLQSCLEFLVPNDNKFVVEAATEYCAQLATHQYGCYVLQCSLINTVGLQHERLVAEISRDSLRLSQDPFGNYVVQCLIDQQVSSVNLLLPFRTHCIELATQKFSSHVIEKCLRKYPESRAEIVRELLSYPNFEQLLQDPYANYVIQTALSVTKGAVRARLVEKVKRFGKLQSNPYCKKIFSKTILKK
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Sequence Mass (Da): 59381 Sequence Length: 528 Domain: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity). Subcellular Location: Cytoplasm
Q9LVC3
MDQRRGNELDEFEKLLGEIPKVTSGNDYNHFPICLSSSRSQSIKKVDQYLPDDRAFTTSFSEANLHFGIPNHTPESPHPLFINPSYHSPSNSPCVYDKFDSRKLDPVMFRKLQQVGYLPNLSSGISPAQRQHYLPHSQPLSHYQSPMTWRDIEEENFQRLKLQEEQYLSINPHFLHLQSMDTVPRQDHFDYRRAEQSNRNLFWNGEDGNESVRKMCYPEKILMRSQMDLNTAKVIKYGAGDESQNGRLWLQNQLNEDLTMSLNNLSLQPQKYNSIAEARGKIYYLAKDQHGCRFLQRIFSEKDGNDIEMIFNEIIDYISELMMDPFGNYLVQKLLEVCNEDQRMQIVHSITRKPGLLIKISCDMHGTRAVQKIVETAKREEEISIIISALKHGIVHLIKNVNGNHVVQRCLQYLLPYCGKFLFEAAITHCVELATDRHGCCVLQKCLGYSEGEQKQHLVSEIASNALLLSQDPFGNYVLQYVFELQLQWATFEILEQLEGNYTELSMQKCSSNVVEKCLKLADDKHRARIIRELINYGRLDQVMLDPYGNYVIQAALKQSKGNVHALLVDAIKLNISSLRTNPYGKKVLSALSSKK
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Sequence Mass (Da): 68671 Sequence Length: 596 Domain: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity). Subcellular Location: Cytoplasm
Q4PSD1
MDKNFRVNTNDERNIWLSTAVNENLTMASSSSQPQPISSPFHQPENQVNRVNPGSHYYDLETLESSFGGLSFNDSSVGQNGDSIHLPRRTNQVFTGSSSGGAGDDNGYLLPPMGSHHHRELEELQRHNYLNQLRMSYQNDYAHQSYWYNTDGDGNGMLNNGFLNDVPSSSRDRVSDYYTNRFGYEGYNYWRGNEGFDYNQCQASFSAFAKDKEMSERLGMSIFQGTKETVDAIYNGLIGDICELMVDPYGSDVVQLLMRRCSSEQIVQLVDIVTQQMFQFVNICIDSLGTNAIQVLLTCINERAKDQIPRIVDVVRTVALQLSKSNHAIFVILACFRLFPLHCRLLLELIVQNCHQIAIDQHGCCLLQLCFNKDRVPNLEIRQRLIMEAIANALRLCLNCYGNYVVQYIVELNNRYLIDALVRQLIGNYAHLARNKYGSHAVQKLLKLRWIDSRVIVIDLLREIDTLLLDPFGNYVIQTAWFVSKDDVRRMLRYHIERNIPMMRCNKFGNKVLEKLNI
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Sequence Mass (Da): 59449 Sequence Length: 518 Domain: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity). Subcellular Location: Cytoplasm
P0DN95
MSNQNERVAAAPFQEAVESPAQRILWERLRTYDHSFPLSDYSPETLFSSDLQTLEHEFRRFGVSELDRGDQDNYVNGYDALRSFHERSRSASVMGSPYGNLEDVPYLPSNPFFDQTPWSDDAYGYMYGIRNTLLSRAKDGIESHMLQYVIAKGLKETIDKIFDNLISHVCELMLDYYGHKVFRKLMEKCTDEQITRVLDIVLEEPFEFVRLCVHTHGTHAIQGLMRSLCSEEQISRFMETLCYVSLLLTKDVIAHRVILFCFNQFSPSHTRYLLEVIVQNCYQVAIDQNGCCMLKKLIRQSSRELRDPLIKEIISIAVRLCGNCYGNYVVQYLLRLKDYEVTSALSKHLDGNYVQLSYDKYGSHVVQKCLESREFSSRRIIAELLSDIDSLLVDPYGDYVIQTAWIVSEDHVRHVLLFYINRNVPFMRCNVYGRKLLQKLNIWT
Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs. Sequence Mass (Da): 51705 Sequence Length: 444 Domain: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity). Subcellular Location: Cytoplasm
Q46482
MKILIVGSGGREHALAWKAAQSPQVEQVFVAPGNGGTASEPGVENVAIAADDIAGLVEFARRESIGLTIVGPEAPLVLGLVDAFAEAGLPCFGPRQASAQLEGSKAFAKDFLHRHGIPTAAYGVFTELEPALAYLRQVGAPVVVKADGLAAGKGVILADDLATAEAAVHDMLGGGRFGRAGARVVIEEFLTGEEASFIAMVDGRHILPLASSQDHKARDDGDRGPNTGGMGAYSPAPIVTPEIHDRIMREVMEPTVAGLAAEGLPYLGFLYAGLMIGADGTPKVLEFNCRLGDPETQPLLMRLQSDLVELCLAALDGRLDQVTADWDARPALGVVMAAGGYPDDYETGHVISGLDAVPSSEAKVFQAGTRCEGDAILTNGGRVLCVTALGANVAEAQHLAYQAVDRIQWTDAFCRRDIGHRAIARERS
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 44805 Sequence Length: 428 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
O66949
MKVLVVGNGGREHAIAWKVAQSPLVKELYVAKGNAGIWEIAKRVDISPTDVEKLAEFAKNEGVDFTIVGPEAPLVEGIVDEFEKRGLKIFGPNKEAAKLEGSKAFAKTFMKKYGIPTARYEVFTDFEKAKEYVEKVGAPIVVKADGLAAGKGAVVCETVEKAIETLDRFLNKKIFGKSSERVVIEEFLEGEEASYIVMINGDRYVPLPTSQDHKRLLDEDKGPNTGGMGAYSPTPVINEEVEKRIREEIVERVIKGLKEEGIYYRGFLYAGLMITKEGPKVLEFNVRLGDPEAQPILMRVKNDFLETLLNFYEGKDVHIKEDERYALDVVLASRGYPEKPETGKIIHGLDYLKSMEDVVVFHAGTKKEGNFTVTSGGRVLNVCAYGKTLKEAKERAYEAIRYVCFEGMHYRKDIGDKAFKYLSE
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 47430 Sequence Length: 424 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
P52420
MSSLCASNCYPSSSSINLFSNNNNPTKPFLLSLRFASSNSLPFVAPLKFSTTNHVLSNSRFSSNRIQRRLFLLRCVSEESQPSLSIGNGGSEERVNVLVIGGGGREHALCHALKRSPSCDSVLCAPGNAGISSSGDATCVPDLDISDSLAVISFCQKWNVGLVVVGPEVPLVAGLANDLVKAGILTFGPSSQAAALEGSKNFMKNLCHKYNIPTAKYKTFSDASAAKEYIQEQGAPIVIKADGLAAGKGVTVAMELEEAFEAVDSMLVKGVFGSAGCQVVVEEFLEGEEASFFALVDGENAIPLESAQDHKRVGDGDTGPNTGGMGAYSPAPVLTKELQDFVMESIIHPTVKGMAEEGCKFVGVLFAGLMIEKKSGLPKLIEFNVRFGDPECQVLMMRLESDLAKVLLAACKGELSGVSLDWSKDSAMVVVMASNGYPGSYEKGSIIKNLEEAERVAPGVKVFHAGTGLDSEGNVVATGGRVLGVTAKGKDLEEARERAYSAVQQINWPGGFFRHDIGWRALRQKQVATKEE
Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 56473 Sequence Length: 532 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. Subcellular Location: Plastid EC: 6.3.4.13
O29108
MKVLVVDAGGRGNAIAHAFSRSEQVKEIYIAPGNGGSEFFEKCKIAELDGKKIPSIRAIDEIVRFAKKCEVDLAYIGPEEPLSLGLVDRLEEEGIPAVGPKKEATILEASKCWAKDFLKRIGVPIPEYANFDNPEEAKEYIREKFNNGIVVKADGLAAGKGVYVCDSVEEALRAVDEIMVQKKFGEAGNRIVVEERLRGIEVAFTAMTDGKTVKPFGHARDYKRAFDSDDIEGLRDFYIGLTKKFYTKAQIEQLYREGKLINPNTGGMGAVSPHPAVTEEVEQRIMEMVVEPIIENFDKEFKGVLYPVIMLVEENGELIPKVLEINVRDCDPGAEAKLPRLKSDMAEISMAVVEGRLDEVEMRFSSDYCVAVCAVSGALKGREGLKPGYPADHYTSQPITGIEEAMKEAIIYANGIAKTNGYVTTGGRVLTVVGMGQSIEEARSKAYSALEKISFPGMRYRRTIGLDVPE
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 51750 Sequence Length: 470 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
P12039
MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLVNIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGSKQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEEEAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFDGDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTENGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASEGYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARDRVYKAVDEIFKPGLFFRKDIGARALKAAQK
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 45280 Sequence Length: 422 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
Q8RC54
MKVLVVGGGGREHAIVHKLSQSDRVEKIYCAPGNAGIGQLAECVNISVEEIEKLKEFALQNKIDITIVGPELPLVEGIVDEFERTGLKIFGPSKKAAMIEGSKYFAKQIMAKYEIPTGRFKAFDRYQEALKFLKETWYPVVIKADGLAQGKGVFIVRDFIEAKEVLDLMMKKRVFGPSGDIVIVEEMLYGKEASIFAFVDGENVLTMMTAMDYKKVYEKDEGPNTGGMGSIAPNPHIDKKTLNEIEEKILKPVVYALKKEGIVYKGVLYAGLMLTKEGPKVLEFNARFGDPETQAILPLLKTDFLEIIEATLEGKLKNLKLEWEDKKAVCVIAASKGYPGEYKKGFEIRGLEEVKEAFVYHAGTSFKDGKIVTSGGRVFGIVALGDSYKEAREIAYREIEKISFEGIYYRKDIAAGY
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 46436 Sequence Length: 417 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
Q9PN47
MKIMILGSGAREYSIALALRRVDKNLEFYFAPGNGATESLGTNLNLKDPVVLATYAKEKGFDLCIVGSESFLAEGVVDIFKQQGLAIFGPSKAAAMLETSKSFMKSFLKKYRIKTAKFLNTNDIEKAKNFIYSLTPPIVVKADGLCAGKGVIIAKTHEEAIEETAKMLSGESFGDAGKLVVIEEFLDGYELSIFAVCDGNDFVLLPAAQDHKKLLDNDQGPNTGGMGAYAPSSLANESLLRKVQKDIILPTLAGMKKEGAEFCGVLFIGAMIVGNKPYVLEFNVRFGDPECEVLMPLIEDPLELILAATQRRLRHSKIKIKKEFAVGVVCASENYPYKSSPKSEITVNNIPENSHISYAGVSLEDGKLMADGGRVLVCVGTGKSIEEAQKNAYKLCDNVNFKGKQYRKDIAHQVLK
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 45316 Sequence Length: 416 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
Q8KBV8
MKVLIIGSGAREHAMAWAVARSSKVSTVFVAPGNGGTATMGGKVRNTPVKATDIDALLELVAKESIGLTVVGPEQPLEAGIVNRFREAGFKVVGPTAEAAQLETSKVFAKEFMKRHGIPTAGYEVFRDYASAKAFLETCPTFPQVIKASGLCAGKGVVVAMSRDEALEAIHEFFESRIFGDAADEVVIEAFLSGQEASVFALTDGQNYQLFLSAQDHKRIGEGDTGKNTGGMGAYAPAPLVTPEVMRRVEEEVIRPTLAGMRADGYAYTGFLYVGLMIDKGVPSVVEYNARLGDPETQVVLPMLKSDLFDALLASVEGGLEVVPFEMQEGAAATVVMASAGYPDAYETGKVITIDPTVNDMEGVLVFHAGTRRDGDALVTSGGRVLSVTACAGSLKEALDRVYRAVDAIEFEGAYCRRDIGAKAL
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 45064 Sequence Length: 425 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
Q97J90
MKILLIGSGGREHAMAWKMAQNKSVERIYCAPGNGGTAKENKCENVNLEKTEELIEFASKNNIDLTVVGPEAPLVDGIVNEFKEKGLKIFGPGKVGAQLEGSKSFSKDFMKKYNVKTAEYAVFENSEESLEYLKKCTYPIVIKADGLAAGKGVVICEDYKLAEETIKAFMVKDVFKGSGKKVVIEEYLEGVEASILSITDGKAIIPFVSSKDHKQIFDGNKGPNTGGMGAISPNPYCTEEVLKSFEEEILKPTLIGIQEERMDFTGIIFFGLMITKKGVYLLEYNVRLGDPETQVVLYLMKSDFVDLINAAMDKKLSDFDIEWYDGNACCVVAASKGYPKNYSTGYEISGIDDAGDKVFCAGVKLENGVYKTSGGRVLCASARGITLDEAIKKAYTDIERIKFDGIYYRKDIGKSK
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 45754 Sequence Length: 416 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
Q8NMH3
MRILVIGSGAREHALLRGLSTDPATTELHVAPGNAGLGSIATVHPGIKADDPEAVTALAKELNSDLVVIGPEIPLVAGVADALRAAGIAVFGPNKDAARIEGSKAFAKDVMAAQGVRTAHAEAITPGASSEDIDAAIDRFGPTWVVKDDGLAAGKGVVVTPDRAAARAHVDAVLEGGNPVLLESFLDGPEVSLFCLVDGETVVPLLPAQDHKRAYDNDEGPNTGGMGAYAPLPWLPEDGVQRIVDEVCVPVAREMVARGCAYSGLLYAGIAWGAEGPAVVEFNCRFGDPETQAVLALLKTPLAVLLNAVATGTLAEQPALEWEDAYALTVVLASYNYPEAPRTGDVIRNADADNVLHAGTALNAEGELVSAGGRVLNVIGVGETLEAARDNAYTTIKDIELEGSHYRSDIALAALEGRISI
Cofactor: Binds 1 Mg(2+) or Mn(2+) ion per subunit. Catalytic Activity: 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 43545 Sequence Length: 421 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. EC: 6.3.4.13
O27272
MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGAGHFAALVRMGDVAIAMSTDGVGSKILVAEMMNRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAMGAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRIITGEDVSPGDTVIGLESSGIHSNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVHGLAHITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAVVAPDDVDEALSILGDRAHPIGEVTDRGSEVELEACTGETIKL
Catalytic Activity: 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate Sequence Mass (Da): 35983 Sequence Length: 338 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. Subcellular Location: Cytoplasm EC: 6.3.3.1
Q1D8V5
MGTTYKQSGVDIEAGDAFVERIKPHAARTMRPEVMGGVGGFGGLFALPPGKYQQPVLVAGTDGVGTKLKVAFAAGRHGTVGIDLVAMSVNDILTCGAEPLFFLDYFATGRLEVDDAAEVVKGIALGCEQAGCALLGGETAEMPGFYARGEYDLAGFCVGVVERAAIIDGKSVKPGDALIGLPSSGLHSNGYSLARKVLLDDGKLALDATPEGLDRPLVDALLEPTRIYVKDVLALLQAVKVKGLAHITGSGIPGNLPRCLPDGTRAVLSEQTWPKPPIFDLIAKLGSVARDEMFNTFNMGLGLILVVAKEDVAQALSVLSGRGVQAFEVGRVEAGQGEATAVIDP
Catalytic Activity: 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate Sequence Mass (Da): 35858 Sequence Length: 345 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. Subcellular Location: Cytoplasm EC: 6.3.3.1
Q9JZ80
MSTSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYQNPVLVSGTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITGRSIGVGDVVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTIKGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQGDEHQTQVA
Catalytic Activity: 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate Sequence Mass (Da): 36974 Sequence Length: 344 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. Subcellular Location: Cytoplasm EC: 6.3.3.1
A1JKZ7
MTNKTSLSYKDAGVDIDAGNDLVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAASVITGIAEGCKQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVAPGDALVALGASGPHSNGYSLVRKILEVSNTDPEQTQLDGKSLADHLLEPTKIYVKSILSLIEQLDIHAIAHLTGGGFWENIPRVLPQGTQAVIDEASWQWPAVFSWLQETGNVSRHEMYRTFNCGVGMVVALPAELADKAVELLTASGEKAWKIGVIAAAAEGAEQVIINP
Catalytic Activity: 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate Sequence Mass (Da): 36823 Sequence Length: 347 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. Subcellular Location: Cytoplasm EC: 6.3.3.1
Q5WW20
MPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSVWWFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPVEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETIHDRPISPHEIVAEGWMTQEDWDETSSYALRLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPENIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVNDRILHNIQHWLG
Catalytic Activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate Sequence Mass (Da): 35911 Sequence Length: 312 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. EC: 6.3.2.6
Q72UH8
MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVPNHILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAGIKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENRIGKELFNILKEKSISIFLRASEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILRNYLETTSWNKMPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK
Catalytic Activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate Sequence Mass (Da): 32472 Sequence Length: 285 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. EC: 6.3.2.6
B2GF71
MEEKLLYAGKAKEMWTTEDEDQLRVVYLDQATQLNGKQKEHFAGKGAAAHAISDLVFHYLIDHGIETHFIKKLSATEDLVEKCAMVPLEFVTRNTVAGHFASRFGLEEGTALPQPVEENFYKDDELDDPFINESAAVALKMVTPAEFDRCWAICRQVDQLLTPLFEKAGMQLVDFKLEFGRRSRDNQIILADEFSPDNCRLWDTTTHHHLDKDVFRRNLADLTATYQEVYARLQAALKED
Catalytic Activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate Sequence Mass (Da): 27483 Sequence Length: 240 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. EC: 6.3.2.6
Q8Y6B9
MTNELVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAEAGIESHFIRAISETEQLVKEVSIIPLEVVVRNVMAGSLAKRLGKEEGEQIPNAIVEFYYKDDALDDPFINDDHVLYLEVATTSEMDTIRQAARSINKVLQELFNQMNITLIDFKLEFGRDAAGEILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLTDVYTEVLNRLKQVQN
Catalytic Activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate Sequence Mass (Da): 26841 Sequence Length: 237 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. EC: 6.3.2.6
Q9A1Z3
MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVVTHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGHVLETPIVEFYYKNDDLDDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKGWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
Catalytic Activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate Sequence Mass (Da): 26837 Sequence Length: 234 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. EC: 6.3.2.6
P31335
MAARQQLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDAGLPVRDVSDLTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMNKQDFSLVRVVVCNLYPFVKTVSSPGVTVPEAVEKIDIGGVALLRAAAKNHARVTVVCDPADYSSVAKEMAASKDKDTSVETRRHLALKAFTHTAQYDAAISDYFRKEYSKGVSQLPLRYGMNPHQSPAQLYTTRPKLPLTVVNGSPGFINLCDALNAWQLVKELKQALGIPAAASFKHVSPAGAAVGIPLSEEEAQVCMVHDLHKTLTPLASAYARSRGADRMSSFGDFIALSDICDVPTAKIISREVSDGVVAPGYEEEALKILSKKKNGGYCVLQMDPNYEPDDNEIRTLYGLQLMQKRNNAVIDRSLFKNIVTKNKTLPESAVRDLIVASIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWIAKLTAVSLSSDAFFPFRDNVDRAKRIGVQFIVAPSGSAADEVVIEACNELGITLIHTNLRLFHH
Function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis . Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) . Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity). Catalytic Activity: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 64415 Sequence Length: 593 Domain: The IMP cyclohydrolase activity resides in the N-terminal region. Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. Subcellular Location: Cytoplasm
A9WEK8
MIGEERVVRALMSVYDKTGIVEFAQALHNLGIEIISTGQTQRVLREAGIPALPVSDVTGFPEILDGRVKTLHPAIHAGLLARRDVPAHMAELAAHNLQPIDLVVVNLYPFAATIARPDVTMAEAQEQIDIGGVALLRAAAKNFPAVLVLVDPADYAGVLDGLRAGDVPLSERQRLAAKAFAHTAEYDATIAAYLRTEPLPDVLPLAWRKYQPLRYGENPHQAAALYGDFGAFFHQLHGKELSYNNILDTAAAQELIEEFPATEAAAVAIIKHTNPCGVAIAADLHRAWEAAFATDREAPFGGIIAVNRPVDIAFAEAVDEIFSEIIIAPDFAPDALALLRRKKNRRLLQSVRPITGADRWQLRSVPGGVLVQEPDHAPLVAEEWRVVTKRAPTDAEAAALRFAWRVVKHVKSNAIVYAAHDRTLGIGAGQMSRVDSSRLAVWKAQQAGIDLRGSVVASDALFPFADGVEAAIAAGATAIIQPGGSVRDEEVIAAADAAGAAMVFTGRRHFRH
Catalytic Activity: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 55050 Sequence Length: 512 Domain: The IMP cyclohydrolase activity resides in the N-terminal region. Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
B3QS62
MAERKIKRALISVSDKTGIIDFAKSLAEFGVEIFSTGGTLKKLIEAGIAAKSISEITKFPEIMDGRVKTLHPAIHGGLLAVRGNSDHEKQAAENNINFIDLVAVNLYPFEATVAKPDVTFADAIENIDIGGPSMLRSAAKNHKSVTVITDAADYQCVLEEMRANDGATTEATRLYLAKKVFALTARYDGAISNYLEKISQTDESVLPNHLSVSLTKEIDMRYGENPHQKAGFYAMKVGEQNLSFDEFFEKLHGKSLSYNNLLDISAAAGLIEEFRGAEPTVAIFKHTNPCGVAQADSLETAYRKAFSTDTQAPFGGIIAVNRPLDMATAKAINEIFTEIVIAPEFEEGVLEYLMKKKDRRLIRQLKALPSSALEFRSTVCGLLVQDKDAKTATKEELKVVTKRQPTEAELEDLLFAWKICKHVKSNTIVYAKDMQTVGVGAGQMSRVDSSRIARWKAGEVNLELKNSVVASDAFFPFADGLIAAAEAGASAVIQPGGSIRDEEVIAAADERNIAMVFTGTRHFRH
Catalytic Activity: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 57327 Sequence Length: 525 Domain: The IMP cyclohydrolase activity resides in the N-terminal region. Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
Q8KFK6
MLDPVIKRALVSVSDKTGIVDFCRELASMDVEIFSTGGTLKLLQGAGIVAQSISTITGFPEIMDGRVKTLHPKIHGGLLAVRDNAEHQKAARENGIQFIDLVVVNLYPFEATIAKADVTFEEAIENIDIGGPSMLRSAAKNNESVTVVTDVADYATVLDEMRSNGGATTRATRLTLAAKVYALTSRYDTAIAAYMAKAAGVKGAGDTMTLKLEKELSMRYGENPHQSAGLYKMDDGNGVRSFSAIFEKLHGKELSYNNMLDIAAATGIIEEFRGEEPSVVIVKHTNPCGVAQAPTLCEAYRKAFSTDTQAPFGGIIAFNRPLDMETASAVNEIFTEILIAPAFEDGVLEMLMKKKDRRLVLQKQPLPKAGWEFKSTPFGMLVQERDSKTVAPEELKVVTKRQPTAEELADLMFAWKIVRHIKSNTILYVKNRQTFGVGAGQMSRVDSSKIARWKASEVALDLRGSVVASDAFFPFADGLLAAAEAGVTAVIQPGGSIRDNEVIEAADANNLAMVFTGMRHFKH
Catalytic Activity: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 56743 Sequence Length: 523 Domain: The IMP cyclohydrolase activity resides in the N-terminal region. Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
Q97J91
MIKRALISVFNKNGILKLAKFLNEKGVEILSTGGTYKHLKENGIPVIEVSEVTGFDEILDGRVKTLHPKIHGGILAIRDNKEHMDTIKNKGITPIDMVVVNLYPFFDKVKENISFEEKVEFIDIGGPTMIRAAAKNFQDVVVLTDVNDYDDVIDQIEKTGEVAYNTKKRLAGKVFNLMSAYDGAISRFLLEDEYPEYLAVPYKKKMDLRYGENPHQTAAFYEAAFGDGAMKGFEQLNGKELSYNNIKDMDIAWKVVNEFDETVCCALKHNSPCGVAIGENPLDAYKKAFECDDTSIFGGIVALNKVIDKPAAEEMVKIFLEIVIAPDFTADALEVLKSKKNLRVIKANEKPSDNFELAKVDGAMLVQSADNKLTEKMEVVTDKKPTDEEMRDMIFGMKVVKYVKSNAIVVVKNGAAVGIGGGQVNRIWPAKDAMERGKGAAVLASDAFFPFGDIVEEAHKNGIKAIIQPGGSIRDQESIDGCNKYGISMVMTGIRHFKH
Catalytic Activity: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 55238 Sequence Length: 499 Domain: The IMP cyclohydrolase activity resides in the N-terminal region. Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
Q7UKJ8
MSDVVPVRNALISVSDKMGLADFAAGLSAAGVTIYSTGGTRAHLEQSGIKVEDVAEYTGFPEMLDGRVKTLHPRIFAGILARRDLDDHMDTIADHDIEPFDLVVVNLYPFAATVSRSGATRAECIEQIDIGGPSLVRAAAKNHGDVAIATSPEQYGDVLDQLETLGGTTDELRTQLAAEAFDHTAGYDRAIADYMQGDAVGGEFPASMHVSLRRKTQLRYGENPHQRAALYSDSSDRSANLVSARQISGKELSYNNLLDLDAALDIARGFAEPAVSVIKHNNPCGAATGDTLSEAVDKAMAGDPLSAFGSVIGMNRTLDEATAEFLCQPGLFIEAIVAPDFEAGAVGLLTTKPRWKDNVRLMQVGRLDEPARKVSRRFISGGMLVQDADRMVSSPLQWNTVTETPVDDDLWDDISFGWEMVRHVKSNAIVLAKDTSLIGVGAGQMSRVDSVEISIKKAAERSEGSILASDAFFPFPDSIEAAAKAGVLAIIQPGGSRRDDEVIAACDEHEIAMVFTGRRHFKH
Catalytic Activity: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Sequence Mass (Da): 56202 Sequence Length: 523 Domain: The IMP cyclohydrolase activity resides in the N-terminal region. Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
O67321
MEKLIILGAQWGDEGKGKIVDLLSEHFDITVRYQGGSNAGHTVVVNSQKFILHLLPTGILHEHVKGVIAQGMVVDLEVLHKEVKNLEEKGIYVKERLFISDRAHLVMPYHKLLDSLFEKKKGIGTTLRGIGPAYMFKYGRKGIRISDLKDEKRFYTLLEDNLDFVKNICEKVFCEKFDLDINQIYEEQLRYFEEFKENVVDLLRFFNTQKGSVLFEGAQGTLLDVDMGTYPYVTSSNASALGLSNGTGMPPKYFSDAFFLGVAKAYTTRVGEGPFPTELKGEEGEKLRELGGEYGSTTGRPRRCGWLDLVALKYAVQVNGLDGFVITKLDVLDTFDEVKVCVAYELDGEVIDYFPASYSELIRVKPVYKTLKGWKKSTKGAKDVSELPKEALDYVKFIEEYTGVPVVMLSTGPKRDEYIWLKEILRTRSGYS
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 48854 Sequence Length: 432 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
Q96529
MSLSSLTLDSNPRFAVGGPYHRRYPPLHHPRSFVSCSAKRPAVSASLSVAADSAATESLGRIGSLSQVSGVLGCQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYNSEGKKFALHLVPSGILNEDTTCVIGNGVVVHLPGLFKEIDGLESNGVSCKGRILVSDRAHLLFDFHQEVDGLRESELAKSFIGTTKRGIGPAYSSKVIRNGIRVGDLRHMDTLPQKLDLLLSDAAARFQGFKYTPEMLREEVEAYKRYADRLEPYITDTVHFINDSISQKKKVLVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPSVVGDLIGVVKAYTTRVGSGPFPTENLGTGGDLLRLAGQEFGTTTGRPRRCGWLDIVALKFSCQINGFASLNLTKLDVLSDLNEIQLGVAYKRSDGTPVKSFPGDLRLLEELHVEYEVLPGWKSDISSVRNYSDLPKAAQQYVERIEELVGVPIHYIGIGPGRDALIYK
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 52964 Sequence Length: 490 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Plastid EC: 6.3.4.4
B6YR45
MKVSVLLGLQWGDEGKGKVVDVLTPKYDIVARFQGGPNAGHTLLFADRKYVLCSIPSGVFQGKVNIIGNGVVLDPILFKAETETLTSSCSNLVDKIYISRKAHLILPTHRLLDVAYETQKGNNKIGTTGKGIGPAYTDKVSRNGLRIGDIDYNFEEKYRYAIARHKELLHQMNFQYDLLPLEREWKKSIEVIKRFKRINSDNFINKALIGGRTVLAEGAQGTMLDVDFGSYPFVTSSNTICASACTGLGVAPAKIGDVFGIFKAYCTRVGSGPFPTELSDEIGEKLRNIGNEYGSITKRPRRCGWIDLVALRYAVMINGVTQLIMMKSDVLDTFDTVKACIAYEVNGQKMEDFPFEIGSSVKPIYTELVGWKTNMTKIKSENEFPKAFKDYLLFLEESLGVSIKIVSLGPDREQTIIRE
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 46614 Sequence Length: 419 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
Q83CV4
MNIVILGTQWGDEGKGKIVDMLTEDVAAVVRFQGGHNAGHTLIIDGEKTILRLIPSGILREGVLCLIGNGVVLSPPALMEEIEELNAKGIPVTEQLRISSACNLLLPYHVALDKAREAELGTKAIGTTGRGIGPAYEDKVARRGIRAMDLLHPDQLLEKIKKATAYHNIQLEHYYHQTPLDYQSIYNQLMEFREKIKPMIGDVSALLGNLRRQNKHIIFEGAQGSLLDIDLGTYPYVTSSNTTAGSAATGSGFGPLYFDRVLGITKAYVTRVGAGPFPTELTNEEGKKMAKRGNEFGSVTGRPRRCGWFDVISMRRTIQINSLTGIVLTKLDVLDEFAKIHLCTAYRCDGEVVNEPPFDQSLLESCEPVYEEMPGWQTSTYGLTDYSEMPKEARNYISRLEELLGVPITIISTGPDRKHTIVRQAVFNQVITAKG
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 47989 Sequence Length: 435 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
P0CQ34
MAPSPEGVTVVLGAQWGDEGKGKLVDILAAEADICARCAGGNNAGHTIVVRNDKGEKTSYAFNLLPSGLINPECTAFIGSGVVVHVPSLFNELDTLERKGLKVAGRLFVSDRAHLVMGFHQIVDGLKEVELGGSSIGTTRKGIGPAYSSKASRSGLRVHHLFDPTFPAKFRKLVEGRFKRYGHFEFDTEGEIEMYLAFAERLRPFIVDGPTFMHNAVNSGKRVLVEGANALMLDLDYGTYPFVTSSSTSIGGVVSGLGISPFAIKRVVGVIKAYTTRVGGGPFPTEDLATVGETLQEVGAEYGTVTGRRRRCGWLDLVVMKYSTMINGYTSLNLTKLDVLDGFDEIKVATGYKIDGVEVEGFPADLDRLAKVEVQYATLPGWKTDISNCKTYEEFPENAKAYIKFIEDYLGVKVQYVGVGPGRDQNVIIF
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 46643 Sequence Length: 430 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
B0W9B4
MEEPSKVSAPTAVNGHPVVQSHAEMHQRCLNPYRSKVTVVLGAQWGDEGKGKVVDMLATEADIVCRCQGGNNAGHTVVVNGVDFDFHLLPSGIINERCKSIIGNGVVIHLPGLFEELAKNEAKGLTNWESRLIISNRAHLVFDLHQQVDGLQEAEKGGKSLGTTKKGIGPCYSSKATRNGIRVSDLLGDFKVFGEKFESLVNMYKRLFPNFEVDIAAELARYRDYADRLRPLVQDTVSFLHGSLREGKSVLVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTELHDEVGSLLQTRGGEIGVTTKRVRRCGWLDLALLRYTAMVNGYTALCVTKLDILDTLKEIKVAVSYNLNGERINYFPGSITALGQVEVNYITVPGWLTSTEGVREFSELPPQAQDYIRLIENDLGVPVKWIGVGKGRESIINVKD
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 49945 Sequence Length: 458 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
A5FQS4
MPVTAIVGGQWGDEGKGKVVDMLAQEADYVVRFSGGDNAGHTVINPMGEFKLHIIPSGVFYPGVKCIIGNGVVINPDVFIRERNELISRGVNVSNVFISDRAHLVLPYHILLDGLEEEARGNKSLGTTRRGIGPAFVDKYARMGIRVGDLLLPEYLRERLEYVLECKNQILTKVYDAAPISLDEIYETCLKWGKELAPNIRETTHIIEEAISQDKKIIMEGAQGALLDPDFGTYPYGTSSSPLAAGGCLGIGIGPASVSATLGVFKAYSTRVGGGPMPTELLDKTGDTIRNEAHEYGTTTGRPRRIGWFDAVAGRFSCQINGMTTAIMTRLDIMDILPKISICTAYELNGKIIKYFPANSGELAKCKPIYEEMPGWLCSTKEVRNYDDLPEAAKAYICRIEKLIGCQMSAVCIGPSREQTIYK
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 46283 Sequence Length: 423 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
Q9RYB5
MPGIAIVGAQWGDEGKGKIVDFLAPEAEYVVRYQGGANAGHTVNAKGKTFKLNLLPSGVLHEGATSILGDGMVIDPEKFIEERRNLMEGGLNPRLKISDRAHIVLPHHKYVDGRKDFVGTTGKGIGPAYADRARRVGIRFGDLLDEGVLRERIERLLEAKPNSTRDAGWATVEDGLKSLAPIREQLAPFIADTGSELRQAIKDGRKVLFEGAQATLLDLNYGTYPFVTSSHPTVGGILVGTGVNHKALHRVYGVAKAFNTRVGHGPFATEVHDEAGILRLRGDGSQPWDEYGTTTGRPRRVGWLDLELLKYAVDVNGLDGLVINKMDILGGLDEIPVCTGYDEGGQPVFKKMKGWSSTDGVTSRATLPKEAQAYLDLIEDTVQCPVVIFSAGPEREKTYGEVHWG
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 43974 Sequence Length: 405 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
A5UN95
MTCSILVGGAWGDEGKGKCITYLCGNDKPDIIARAGVGPNAGHSVEFNGEKYGLRLIPSGFVHTDAKLMIGAGVLVDKDVLFKEFEDLKKYNVKERTFVDPRCAIITKDHRERDKKSEHLAKKIGSTGSGCGPANSDRVLRTVKLANDVPELEDYLADVSLETNDVLDNGGDVFIEGSQGFALSLYYGTYPFVTSKDTTASTFAADVGVGPTKVDEVINVFKAYITRVGEGPFPTEISQEEAESKNIEEYGVVTGRRRRVGLFDMELAKESCRINGATQIALTCVDRLYPDCARTQSYDDLSAETKKFVEEIQSETGVPVTIISTGPDLKDTIDLRKELL
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 37115 Sequence Length: 340 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
B6JUV1
MALVSETGVDVSTDGITVVLGSQWGDEGKGKLVDILCDNVDICARCAGGNNAGHTIVANGQTYDFHILPSGLVNPKSVNLIGSGVVVYLPAFFHELENLVKKGLDCTNRIFISDRAQLVFDYHQRADALNEAELGGKSIGTTGKGIGPAYSTKATRSGIRVHHLYNWPEFESRYRKNVRDLQKRYGAFEYDVEGELVRYKELAAKLQPYVVDSIAFIHTGLKEKKRILVEGANALMLDLDFGTYPYVTSSNTTIGGVCTGLGVPPRAIANVIGVVKAYTTRVGAGPFPTEQLNEIGDHLQKVGREFGVTTGRKRRCGWLDLVVLKYSTLINGYDSLNLTKLDILDDFKEIKVAVAYIVDGKRIETFPADLDSLESAEIIYETFPGWQTKTTGITRWEDMPENAKKYIEFIEKFLGVPIKYIGVGPGRDEVLVKH
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 47819 Sequence Length: 434 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
C4QCD2
MTKSVEGLVSVVLGAQWGDEGKGKLVDLLSESCSVVCRCQGGNNAGHTVVAGGQEYFFHLLPSGIVNPNVLAVIGNGVVVNLQALFQEIDEAVCKGLLDVSSRLRISDRCHLVFDIHQEIDRMEEELRGENSLGTTKKGIGPTYSSKVTRNGLRVCDLMGDWVQFTAKYKELVKYVKRRYPKLGINVEESLEKLSGMVCDSVILINKLVKSKQANILVEGAQSCMLDIDFGTYPHVTSSNCSVGGVCTGLGLSPSRVGRVYGVIKAYTTRVGSGPFPSELLDGIGEFIQKKGCEWGVTTKRKRRIGWLDTVVIRYAHIINDFNALALTKIDVLDDLEEVKIAKAYIDPETGRELDSFPSDSSVLNHVVVVYETLPGWKTSTHGCRVYEELPTAAKVFVETVEKLLNIPIRWIGTGASRDSIIIRSV
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 46669 Sequence Length: 426 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
Q02787
MASVRETGVNVSNDGITVVLGSQWGDEGKGKLVDILCDNVDVCARCQGGNNAGHTIVANGVTYDFHILPSGLVNPKCQNLIGSGVVVYLPAFFSELEKLEQKGLKCRDRIFISDRAHLVFDYHQRADALNEAELGKQSIGTTGKGIGPAYSTKATRSGIRVHHLYHWAEFEARYRKNVADLQKRYGAFEYDVEAELIRYKELAQRLKPFVIDAVAFMYEALQSKKRILVEGANALMLDLDFGTYPFVTSSNTTVGGVCTGLGVPPQRIANSIGVVKAYTTRVGAGPFPTEQLNEIGDHLQSVGREVGVTTGRKRRCGWLDLVVVKYSTMINGYTSLNLTKLDILDALDEIKVAVAYIINGKRIETFPADLDSLEEAEIVYETFPGWKVPTTGITHWDQMPENAKKYIEFIEKFVGVPITFIGVGPGRDEMLVKE
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Catalytic Activity: GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate Sequence Mass (Da): 47877 Sequence Length: 434 Pathway: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.4.4
Q55498
MTSPSPLVGIIMGSDSDLPTMAAAIAVCEEFAVPTEVAIISAHRTPERMVEYAQTAHQRGLRIIIAGAGGAAHLPGMVAALTPLPVIGVPVQTKTLQGVDSLYSIVQMPGGIPVATVAIGNAKNAGLLAVQILASHNPVLLEKVQQYRQSLETMVLDKQAELERLGYRAYLDQQNQ
Function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). Catalytic Activity: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate Sequence Mass (Da): 18604 Sequence Length: 176 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. EC: 5.4.99.18
Q9WYS7
MPRVGIIMGSDSDLPVMKQAAEILEEFGIDYEITIVSAHRTPDRMFEYAKNAEERGIEVIIAGAGGAAHLPGMVASITHLPVIGVPVKTSTLNGLDSLFSIVQMPGGVPVATVAINNAKNAGILAASILGIKYPEIARKVKEYKERMKREVLEKAQRLEQIGYKEYLNQKE
Function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). Catalytic Activity: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate Sequence Mass (Da): 18618 Sequence Length: 171 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. EC: 5.4.99.18
Q73PV9
MRPLVIILMGSSSDMGHAEKIASELKTFGIEYAIRIGSAHKTAEHVVSMLKEYEALDRPKLYITIAGRSNALSGFVDGFVKGATIACPPPSDSFAGADIYSSLRMPSGISPALVLEPKNAALLAARIFSLYDKEIADSVKSYMESNAQKIIEDDSKLKR
Function: Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). Does not accept N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) as a substrate. Catalytic Activity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 Sequence Mass (Da): 17196 Sequence Length: 159 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1. EC: 4.1.1.21
O66608
MLTVGILGGGQLGWMTILEGRKLGFKFHVLEDKENAPACRVADRCFRTGQISEFVDSCDIITYEFEHIKDEVLEKCESKLIPNPQALYVKKSRIREKLFLKKHGFPVPEFLVIKRDEIIDALKSFKLPVVIKAEKLGYDGKGQYRIKKLEDANQVVKNHDKEESFIIEEFVKFEAEISCIGVRDREGKTYFYPQPFNKHEEGILIYNYVPYAKLKEAEEITKRLMELLDIVGVFTVEFFLLKDGRVLINEFAPRVHNTGHWTLDGAYTSQFENLLRAITEMPLGSTELKLPSGMVNILGKSYEEIPLKEILSVEGAKLYWYGKEKKPRRKVGHVNVVGRSKEEVVEKVERVFTLLKGSREKLPAP
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Catalytic Activity: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate Sequence Mass (Da): 41988 Sequence Length: 365 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. EC: 6.3.4.18
P12045
MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDSPCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELLLITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQFVIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNILFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHNSGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEAKLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Catalytic Activity: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate Sequence Mass (Da): 42320 Sequence Length: 380 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. EC: 6.3.4.18
P52559
MDKTSLKPGSTIGIIGGGQLGRMLAMAAARFGYETIILEPQAGCPAAQVANRQIVAAYDDPKALAELAAASDVITYEFENVPVSAADKLAETALVLPPPAALEISQDRFTEKQFLNESGIETAPWRLVDDEETLIAALGALGGRGILKIRRLGYDGKGQVRLASLDETQACNAFAAINKAPAILEGFVEFEREVSVIAARDRSGNVAIFDLAENVHKDGILATSTVPAAISVQTAEAARTAAEKLLHALDYVGVLGLEFFVLKDGTLLANEFAPRVHNSGHWTEAACAISQFEQHIRAVAGLPLGNTDRHSDCVMENLIGDDIEKVPAILCEKNAVLHLYGKKEARAGRKIGHVTRIKPRTI
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Catalytic Activity: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate Sequence Mass (Da): 38682 Sequence Length: 362 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. EC: 6.3.4.18
Q44678
MKRVSEQAGNPDGNPQAHVPGMPVIAVIGDGQLARMMQTAAIELGQSLRLLAGARDASAAQVCADVVLGDYTNYDDLLKAVDGATAVTFDHEHVPNEHLTALIDAGYNDQPQPAALINAQDKLVMRERLAELGAPVPRFAPIESAQDAYDFWTLTSGQVCLKARRGGYDGKGVWFPNNESELTALVSDLSRRGVALMAEEKVGWSRELSVLVARTPSGEVATWPLTESVQRNGVCAEAVAPAPGVDPQLQQRAETLGEKIATELGVTGVLAVELFAFANESGAEDIAVNELAMRPHNTGHWTLVGSVTSQFEQHLRAVMDEPLGDTSTLAPVTVMANVLGADEDQRCQWASVPRSGAPVPATKVHLYGKGIAQGRKIGHVNLTGEDEEATRRDARLAADFLVNAAWSDNWSAK
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Catalytic Activity: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate Sequence Mass (Da): 44111 Sequence Length: 413 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. EC: 6.3.4.18
P09029
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVPFQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVKRRTGGYDGRGQWRLRANETEQLPAECYGECIVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQAQAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHNSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMINLIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Catalytic Activity: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate Sequence Mass (Da): 39461 Sequence Length: 355 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. EC: 6.3.4.18
P43850
MQNSTLYPTVYVLGNGQLGRMLRYAGAPLDIYVEPLAFNAPVFDLPENAIITAEIERWEKTPLTELLGNHKNFVNQHIFGLLADRFTQKSLLDELNLSTSPWCLLKDKNQWNDLFQTVGEKVVVKRRTGGYDGRGQWIIRDENRADITDDLFGEVIAEKFIPFDYEVSIVGARFKNGEKRFYPVTHNLQQNGILRYSVVDCAFPQQSVQQKQAETMLGKIMDKLGYVGVMAMECFVVGDKLLINELAPRVHNSGHWTQLGCSISQFELHLRALLNLPTPELQTFAPSVMINLIGTNHNPKWLNIPFAQLHWYGKEVRIGRKVGHINLSHPNKAVIIQQLEKLCTELPEDYQSGLNWAIEKLK
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Catalytic Activity: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate Sequence Mass (Da): 41273 Sequence Length: 362 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. EC: 6.3.4.18
P65899
MMAVASSRTPAVTSFIAPLVAMVGGGQLARMTHQAAIALGQNLRVLVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGADVLTFDHEHVPNELLEKLVADGVNVAPSPQALVHAQDKLVMRQRLAAAGVAVPRYAGIKDPDEIDVFAARVDAPIVVKAVRGGYDGRGVRMARDVADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAWPVVQTVQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETTDGALLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPVTVMANVLGAAQPPAMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGSDVAQLCERAELAAHWLSHGRWTDGWDPHRASDDAVGVPPACGGRSDEEERRL
Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Catalytic Activity: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate Sequence Mass (Da): 45695 Sequence Length: 429 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. EC: 6.3.4.18
B2IU46
MTATSPAFFSPQEIAAEGLKPEEYAEIVRRLGRHPNKAELGMFGVMWSEHCCYKNSRPLLKQFPTEGPRILVGPGENAGVVDLGDGLQLAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGSLEDAKTQRLFQGVVAGISHYGNCVGVPTVGGEVYFDPAYSGNPLVNVMALGLMETQEIVKSGASGLGNPVLYVGSTTGRDGMGGASFASAELSDQSIDDRPAVQVGDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGITCSTSEMAAKGGVGIELDLDKIPARETGMVPYEYLLSESQERMLFVAHKGREQELIDIFHRWGLQAVVAGTVIAEPIVRILFQGGVAAEIPAEALAENTPLYNRELLAEPPEYARQAWEWTPDSLPACTTAGIEIQGGQQSWNDILLTLLDTPTIASKNWVYRQYDHQVQNNTVILPGGADAAVIRLRPLEEIPNLKSKIPNLKLGVAATVDCNPRYVYLHPYEGAKAVVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLAEACRGLAEGCRELATPVTGGNVSLYNETLDSQGIPQPIYPTPVVGMVGLIPDITKICGQGWQASGDVIYLLGLPLASKISLGASEYLATIHNTVAGKPPLVDFDLERRVQKVCREGIRNGWIRSAHDSAEGGVAIALAECCIAGNLGAEINLEIAPMQNRVDEMLFAEGGARILVSVTSAQQAIWESYLQEHLGQQWQILGTVGNFETGLGVFTTDNQILIKVSIEDMSDRYSHAIARRIATNTAVS
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 84417 Sequence Length: 788 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
Q8ES96
MQLTHDIQPEKIEKDRLYLDMGLSDEEFQRIKQILGRHPNFTETGIFSVMWSEHCSYKTSKPLLKKFPTDGPHVLQGPGEGAGVIDIGDEQAVVFKIESHNHPSAVEPYQGAATGVGGIIRDVFSMGARPIASLNSLRFGPLTNNRTKYLFSEVVAGIAGYGNCVGVPTVGGEVQFDESYEDNPLVNAMCVGLINHKDVQKGIAAGIGNTILYAGPPTGRDGIHGATFASDDLAEDSNKDRPAVQVGDPFMEKLLIEACLEVIQSDALVGIQDMGAAGLTSSASEMASKAGTGLEMNLDLVPQREQGMTAYEMMLSESQERMLLCVQAGREQEIIDIFEKYGLKSVPVGKVIEEKVFRIKHLDEVVADIPVDSLADDAPVYNMPSKEAAYYRAFQQMDIATPAIEDYANTLKQLLQQPTIANKEWVYDQYDSMVQTNTVVTPGSDAAVVRIKGTEKALAMTTDCNSRYIYLDPETGGKIAVAEAARNIVCSGAKPLGLTDGLNFGNPTNPEIFWQMEKSVEGMSAACDALHTPVISGNVSLYNQSKGKSIYPTPIVGMVGLHESTQHITPSYFQEKEDVIYCIGEAKAEFGGSELQHLYSGKYEGKAPHIDLDVEAERQEKLLSAIKEGIISSAHDISEGGLAIALAESLFNGQGLGAEINVVGDATVELFSESQSRFLVSVNKKHANAFESHFPEAAKLGKVTDQGQLTISISDKTIIHERVEELENLWKGAIPCLLKSKA
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 80444 Sequence Length: 742 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
Q4FLJ4
MIVNEQLAIDHGLKKDEYKKICDLLKRVPNITELGIFSAMWNEHCSYKSSRFHLKNLPTKGKNVIQGPGENAGVIDIGDDDAIVFKIESHNHPSFIEPYQGAATGVGGIMRDVFTMGARPIANLNSIHFGSPQHKKTKNLLRGVVHGIGGYGNCMGVPTIAGQTSFDESYNGNILVNAMTLGHVKKDKIFYSKAAGLGKPVIYVGSKTGRDGIHGASMASASFDDKIEEKKPTVQVGDPFTEKLLLEACLELMAGDSIIAIQDMGAAGLTSSSIEMASKGNLGIEINLSKVPCREANMSPYEIMLSESQERMLIVLENGKEEMAKKIFDKWNLDFAVIGQTTKSKKIELYFNEEKVADIPVNTLVENSPMYDRKWKKAKLPKRIKVDKEQFKTLKVKNVLNKILSNPNVCSKEWIWQQYDHTVMGDTIQKPGGDAGVVRVHGTNKAVAASVDSSAVYCWAHPLSGGKQIVCESWRNLISVGAKPIAITNCLNFGSPENEENMGEFVECVQGLGEASAYLEFPVVSGNVSFYNQTKDIGIKPTPAIGGVGLIKDYQNMVTMDLKEADNILLVIGKTEGHLDQSLFARDILNEKNGPPPEINLFNEKNNGETILKLINKKFIKSAHDVSLGGIITALSKMCIKGKKGATLKKSNYLINQFEYLFGEDQGRYIIEISKDDLENATKILQENSVHFDELGLVNEDGLIIDDKTKVSIDDLIKSHTNWLTNYMEN
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 80411 Sequence Length: 730 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
A9BIH4
MQNQLTIKEIALELGISREEFDLIEEKLGRIPNEFETYLFSAQWSEHCGYKHSKHYLKKINESYESENAGYVQIGGKAVVFKVESHNHPSAVEPYQGAATGIGGIVRDILAMGARPIALLDSLKFGNVFDPKVKNIFEGVVSGISDYGNSIGVPTVGGETSFNEIYSTNPLINVMCVGVANKNHLASSHADGPDKLLVYVGSKTGRDGIHGASFASKKLSGKDDRPSVQVGDPFTEKNLIEATLEILKIKGVRACQDMGAAGVLSSTSEMAYKGGVGCELYLDNIPKRQEDIEPWEIMLSESQERMLFLVNPGTEKKVEAICNKYLIDFAVIGKTISTPHYVVKENSEGKVLADLPIDILVNAPEYYRNNTIPSTYILNKAKKYPKTKIKDIDKILKILLSNHNISSKKWIYQQYDYKVETNTIFIPEQADSAVLWLKKTQKAIAVTIDSNELYTYLDPFEGTKNVVYEAARNLISVGAKPLAITDNLNFGDPDDPEVSWQFEKSIEGLIEASKELSTPVVSGNVSFYNSYHETSIFPTPVIGMIGEIKDIKKIVNLKFKDCGDVVYLIGKTDINVDKIGGSFYLKVLEGFVGGEIDFVNPMYERYLQNFILDLIDKGILKSVHDVSKGGLLTALAVSCILSNRGFKGILDASIEELFGENQGRFIVSVRSKDSRIFEDIAKSSNINVKKLGEIKSSDDGIDICSAYFDLKELKSIYFDSISKSVEE
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 80462 Sequence Length: 727 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
Q59042
MKIAVTKFLGTNCDLDVCHAVKLAGGEPELVFFTQENLDSYKGAVIPGGFSYGDYLRAGAISARTPIIKGLKKMVEEGKPVLGICNGAQIGLEAGFSKGTLTNNLNAKFICKWVYIRVENNKTPFTQYYKKGEVLKIPIAHAEGRFYADDETLDYMYKNNMIVFKYCDETGEVTEEANPNGSIDNIAGVCNENQNCVLLMPHPERASEKILGSDDGLKMFKGMIDYAKRI
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 25417 Sequence Length: 230 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
Q8TX85
MVRVAVIRFPGTNCDLEMAWAVKLAGGDPEFVWHEDGGLDDFDAVIIPGGFTYGDYIRAGAIAALSPILEEIRECAEDGRPVLGVCNGMQILAEAELIPGTLTVNVGNRFICDWVYLRVERTDTPFTTKYQEDEVIRVPIAHAEGRYYYENPEEIEDNVVFRFCGPDGDVSEEYNLNGSVGGITGVVNDDGNVLGMMPHPERAAHRLLNSDDGLRLFESLVEWCRS
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 25032 Sequence Length: 226 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
A4G010
MVPKVLVMSGYGINCETETAHAFQKAGAETDIVHINDLIAGKKKMADYEIIMFPGGFSYGDDTGSGNAFANKIKNNLFDDLKEFINSGKLILGICNGFQVMTNLGLFALPSTDYGERISALEANTNNRYECRWVHVKENDSICVFTKGITITHVPIAHGEGRFYCDEKTYFELKENKQIVFSYCDSEGNSANQEYPLNPNGAYYDIAGICDKTGRIMGLMPHPERSLYSISEPEYQLKKEIAKRNREIIPEFIESNLQIFKNAVEYFNK
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 30314 Sequence Length: 269 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
O26270
MRVGVIRFPGSNCDRDVHHVLELAGAEPEYVWWNQRNLDHLDAVVIPGGFSYGDYLRAGAIAAITPVMDAVRELVREEKPVLGICNGAQILAEVGLVPGVFTVNEHPKFNCQWTELRVKTTRTPFTGLFKKDEVIRMPVAHAEGRYYHDNISEVWENDQVVLQFHGENPNGSLDGITGVCDESGLVCAVMPHPERASEEILGSVDGFKFFRGILKFRG
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 24274 Sequence Length: 218 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
A0B5C6
MRIAVIQFPGTNCEHETLVAVRECGMDGEIFRWNRPEQELCEFDGYVIPGGFSYQDRVRAGVIASKEPVMATLREEAANGKPIIGICNGFQILVESGILPFGDGVRLALAQNVMIRGGEIVRRGYYCAWTMLRHDAEEKRCSGSYILRRGEILSIPIAHAEGNLVASDRKVIERLIEDDQIVFRYCSPQGEIINEFPVNVNGSTENIAGISNPEGNVLGMMPHPERAFFAWQLPRKHPRIPGYGPGRKIFDSMKRYIEERRS
Function: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. Catalytic Activity: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 29483 Sequence Length: 262 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Subcellular Location: Cytoplasm EC: 6.3.5.3
P46456
MATIKDVAKMAGVSTTTVSHVINKTRFVAKDTEEAVLSAIKQLNYSPSAVARSLKVNTTKSIGMIVTTSEAPYFAEIIHSVEEHCYRQGYSLFCVTHKMDPEKVKNHLEMLAKKRVDGLLVMCSEYTQDSLDLLSSFSTIPMVVMDWGPNANTDVIDDHSFDGGYLATKHLIECGHKKIGIICGELNKTTARTRYEGFEKAMEEAKLTINPSWVLEGAFEPEDGYECMNRLLTQEKLPTALFCCNDVMALGAISALTEKGLRVPEDMSIIGYDDIHASRFYAPPLTTIHQSKLRLGRQAINILLERITHKDEGVQQYSRIDITPELIIRKSVKSIL
Function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. Sequence Mass (Da): 37508 Sequence Length: 336 Domain: Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization. Pathway: Purine metabolism; purine nucleotide biosynthesis [regulation].
Q0I600
MTNFPKTVMLLGSGELGKEVAIAAQRLGCHVIACDRYADAPAMQVADQAEVLTMTDPNALKTVVNKHQPDVLIPEIEALAVDALQALEDTGICVIPTARATAVTMNRDRIRNLAAGELGLRTARFAYASDAQELQRAAAPLGWPVVVKPVMSSSGKGQSVVHSAAELDKAWEIAMAGARGSSAQVIVEEFLDFDLEITLLTIRQHDGTTLFCPPIGHQQANGDYQCSWQPASISPSQLQQAQTMARTVTDNLGGAGLFGVEFFLCGDEVVFSELSPRPHDTGLVTLISQNLSEFDLHLRAVLGLPIPSITAADAAASRVILAESQGHHVQFSGVEQALTEPDTNLLLFGKREARPGRRMGVALARGTQINEALAKADRCAAAVKVQVMD
Function: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Catalytic Activity: ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 41492 Sequence Length: 389 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1. EC: 6.3.1.21
Q3AUF2
MTAFPRTVMLLGSGELGKEVAIAAQRLGCRVIACDRYANAPAMQVADTAEVFQMTDATALKEVVQRHRPDVVIPEIEALAVEALAELEQDGITVIPTARATAFTMNRDQIRDLASGELGLHTARFAYASNAAELKKVAAPLGWPVVVKPVMSSSGKGQSVVQTPEQLDQAWEAAMANARGTSNQVIVEEFLEFDLEITLLTIRQRNGETLFCPPIGHEQERGDYQCSWQPAQMSDAQLQQAQTMARTVTDNLGGAGLFGVEFFLCGNEVIFSELSPRPHDTGLVTLISQNLSEFELHLRAVLNLPIPQLTTAPAAASRVILADRELKTVAYEGLEQALREAGTQVLLFGKPNARPNRRMGVALARGEDLSEVRAKADRAAACIQVLDGSARR
Function: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Catalytic Activity: ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 42485 Sequence Length: 392 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1. EC: 6.3.1.21
Q8D2R3
MVTINTALCKNSTRVMILGSGELGKEIAIECQRLGIEVISVDSYSNAPAMHVSHRHHVIDMLNPKEIKRCINLEHPDFIVPEIEAISTNALIELEKNGYNIVPSAKTIHITMNRKLIRVLVSKKLNILTSEYQFASSFDELKIKTKVIGYPCLIKPIMSSSGKGQSVIYNEKELRHSWEKSQTYGRTSLGEVIIEKIIPFDFEITLLVVNSVDGMHFCLPIGHRQEKGDYQESWQPHKMDNVIFEKAKKISKKIVSYLGGYGIFGVEFFIYKDKVIFSEISPRPHDTGMVTLISQNLSEFALHVRSFLKLPIGKIRQYGPSSSVVICGNELYGNKISFSNIECINTNQQIRIFSKPNIKGYRRLGVILDQDETIERSLRKAKKTASKILIKT
Function: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Catalytic Activity: ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate Sequence Mass (Da): 44417 Sequence Length: 392 Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1. EC: 6.3.1.21
Q94JZ8
MEGMLSSGDQQRLVSSFLEIAVGQTAETARQFLQATSWKLEEAIQLFYIGNEGGMLQSGTHTQPASNDDAAAQSWGAATGTGNEMILPNDVDEVRAPLPVVRETLYGESMYYGAMRVGNSQPEPNSLIAFRNFSEEPKSPGIWEPDEGDSSASASASASASESASAPRDSLASLYRPPFHLMFQGSFEQAKTTSSSQDKWLLVNLQSTTEFSSHMLNRDTWANDAVSQTIKANFIFWQVYDDTTEGRKVCTYYKLESIPVVLVIDPTTGQRMRMWTGMVDPENLLEDLVPFMDGGPREHFASLSKKRPRGSFSLTPHSKPKEDVAKDEEEEELQRALAASLEDNNMKESSDDQSTIIPEEVAVEAVTSAVLPTFPPLPEEPKGGDRSLQCRVGIRLPNGQRLQRNFLKTDTIQLLWSFCYSQLEESERKKPLKLTQAIPGESKTLEYESNLTLEQSGVANSMISATWE
Function: Acts as a bridge between CDC48A and ubiquitin, suggesting a role in targeted protein degradation. Sequence Mass (Da): 51808 Sequence Length: 468 Domain: The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins. Subcellular Location: Nucleus
O42173
MVQQGFSIDLILARSREEAADGKDSMSSRPHIPCAPQPLPPNKYAKEMPRRKDGQDVQEHSSWSLGEQGKKLQYSSPSSAALHRSWGSSDDFSSVGSEDDSTEGSPSPMRNSQETETDHRGESPKSDLQRHLRTAFTPQQISKLEQAFNKQRYLGASERKKLATSLRLSEIQVKTWFQNRRMKLKRQIQDQQHNMVPPPVCYPQTFPYYPGVLPVPLNSGSFYQPPAHPFQAPQNSYIPDPRFIPQPLPHHIRMSVALQQQYPPLGLPPGRYFTGLASKNDG
Function: Transcriptional repressor. Acts in a ventral signaling pathway downstream of bmp4, which suppresses dorsal mesoderm formation and leads to both ventral mesoderm and ventral ectoderm formation. Acts in the ectoderm to simultaneously specify epidermal lineages and restrict neuralization. Represses transcription of dorsal-specific genes. Binds to DNA, with preference for the target sequences 5'-TAATGC-3' and 5'-TAATTG-3'. Acts in a pathway downstream of bmp4 and fgf to negatively regulate erythroid specification. Sequence Mass (Da): 31846 Sequence Length: 282 Domain: The repressor activity is mostly localized to the C-terminal region. Subcellular Location: Nucleus
P0C8G6
MSQLRWWVVSQLLLLIVVCILDHSEGARVCPKIVPGLDKLRVGVDITKLDLLPLFDLGDNGFRSAVADYTCDRGQTTVVDGESFDVPDQVDSVVIESSGQQTSSVTTIKSESQISQALSISAGISVDTAKAGFSSSASYAEMQEAITKYGRTVSQMSAVYTTCSANLSPNLLLGQNPLQTLSRLPSDFTADTEGYYDFIKTYGTHYFNKGKLGGMFLFTSETDMSYFQNKNSQQVEANIKATFASILSTETGGSSDQSKEVIEFKESSLITAKFFGGRTNLAADGLTKWQPTIAKLPYFMSGTLSTISSLIADTTKRASMELAVKNYLLKAKVANLDRLTYIRLNSWTVGHNELRDLSAQLQNLKKKTIFSDEDEKLLQSIEDQVSVPAWFSDRTTFCFRSTAVGSADQCNGQSTSTLCAEPNRYTQQYMDKTYLGDTGCRLVWKLSTTESSDWFKSVKVNFRWYPTWSPCACGPVGTPFTISAPANSWTQDYLDVTNPKFGECMLQWMIEVPPTATLWAKNLEFCIDFTCGKKKQCVDANHWTEPYLDISAHEACGMSWALIAK
Function: The egg defensive protein perivitellin-2 is a pore-forming two-subunit glycoprotein that affects both the nervous and digestive systems of mammals . In addition, it is a source of both structural and energetic molecules during embryonic development (Probable). The tachylectin subunit (31 kDa) binds target membranes while the MACPF subunit (67 kDa) disrupts lipid bilayers forming large pores altering the plasma membrance conductance . Both in vivo and in vitro, the protein shows wide pH range stability and is resistant to enzymatic proteolysis from gastrointestinal environments . It specifically binds mature enterocytes but does not cause cell disruption on caco-2 (human colorectal adenocarcinoma cells) or rat intestinal cells . After oral administration to mice, it binds enterocytes and induces large dose-dependent morphological changes on their small intestine mucosa, reducing the absorptive surface (By similarity). Additionally, it is detected in the Peyer's patches where it activates lymphoid follicles and triggers apoptosis (By similarity). The toxin can also traverse the intestinal barrier and induce oral adaptive immunity with evidence of circulating antibody response . The toxin also shows hemagglutination properties thanks to the tachylectin subunit, but does not show hemolytic activity . In addition to enterotoxin activity, the toxin also acts as a neurotoxin, since an intraperitoneal injection induces paralysis of the mice rear limbs, followed by death . PTM: Glycosylated. Contains four O-linked and one N-linked oligosaccharide bonds. The protein contains 2.5% of carbohydrates (high levels of mannose, galactose, and NAcGlucosamine, and small amounts of NacGalactosamine). Sequence Mass (Da): 62518 Sequence Length: 565 Subcellular Location: Secreted
P0C8G7
MVKKIHFIMERHASIVAFLLAVLALTESQAFTSVKLPRDEHWPYNYVSIGPAGVWAVNRQNKLFYRTGTYGDNANMGSGWQFKQDGVGQVDVGKDKVGYINLSGGSLFRIDGISQGNPVGGSPKSWEWWTKYIGMSLREDTRFSSRIENQNKVLTFTFRTCFWASRITNWCFADSSYTETVTAGGSGTWITKSQLKYKSGTFGNPDTEGGDWITVDSGSFQHVSSGSGVVLAVRSNGELVKRTGITCSLPQGSGWTSMLNGMSRVDTYGTVAWAVDTYGDLYFINL
Function: The egg defensive protein perivitellin-2 is a pore-forming two-subunit glycoprotein that affects both the nervous and digestive systems of mammals . In addition, it is a source of both structural and energetic molecules during embryonic development (Probable). The tachylectin subunit (31 kDa) binds target membranes while the MACPF subunit (67 kDa) disrupts lipid bilayers forming large pores altering the plasma membrance conductance . Both in vivo and in vitro, the protein shows wide pH range stability and is resistant to enzymatic proteolysis from gastrointestinal environments . It specifically binds mature enterocytes but does not cause cell disruption on caco-2 (human colorectal adenocarcinoma cells) or rat intestinal cells . After oral administration to mice, it binds enterocytes and induces large dose-dependent morphological changes on their small intestine mucosa, reducing the absorptive surface (By similarity). Additionally, it is detected in the Peyer's patches where it activates lymphoid follicles and triggers apoptosis (By similarity). The toxin can also traverse the intestinal barrier and induce oral adaptive immunity with evidence of circulating antibody response . The toxin also shows hemagglutination properties thanks to the tachylectin subunit, but does not show hemolytic activity . In addition to enterotoxin activity, the toxin also acts as a neurotoxin, since an intraperitoneal injection induces paralysis of the mice rear limbs, followed by death . PTM: Glycosylated. PV2 contains four O-linked and one N-linked oligosaccharide bonds. The protein contains 2.5% of carbohydrates (high levels of mannose, galactose, and NAcGlucosamine, and small amounts of NacGalactosamine). Sequence Mass (Da): 31584 Sequence Length: 286 Subcellular Location: Secreted
A0A060LAL9
MASNESLQTTAAMAPVTIERRVNPNLDDELPKPFLPRALVAVDTEHPSGTPGHQHGDMSVLQQHVAFSNRNNDGIVYPWETFLGFRAVGFNIIISFFGCLIINIFLSYPTLPGWIPSPFFPIYIDRIHRAKHGSDSEVYDTEGRFVPAKFEEIFTKNAKTHPDKLSFSELWNLTEHNRNALDPLGWIAAKLEWFLLYSLAKDPHGFVPKEAARGVFDGSLFEFCEKSRKVKQATVKSLTFKI
Cofactor: Binds 1 heme b (iron(II)-protoporphyrin IX) group. Function: Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies. Catalytic Activity: RH + ROOH = ROH + ROH. Sequence Mass (Da): 27378 Sequence Length: 242 Domain: Transmembrane regions are predicted by sequence analysis tools, but these regions probably constitute hydrophobic domains associated to phospholipids. Subcellular Location: Lipid droplet EC: 1.11.2.3
Q7Z7A4
MAFMEKPPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKRSALENSEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTSGISALPPPPPPPPPPAAPLPPASTEAPAQLSSQAVNGMSRGALLSSIQNFQKGTLRKAKTCDHSAPKIG
Function: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Location Topology: Peripheral membrane protein Sequence Mass (Da): 64950 Sequence Length: 578 Domain: The protein kinase domain is predicted to be catalytically inactive. Subcellular Location: Cytoplasm
Q09476
MPSDDRFADAVKPALEALLSDLQHTTEVLRRAHISDRRSQSRDDFEQSYDLQGNLNTQSVSNGNITTSPYKRRSSEGKDYSKSQERIYENESRLNPPVYSRPSVQSLLSQVEEPPIRASSSRKSLGPPSQAQSYSDVRSNGRSPSRDPLHSDSMIGTMNGELSSKHGVNTIPKGDCAACGKPIIGQVVIALGKMWHPEHYTCCECGAELGQRPFFERNGRAFCEEDYHNQFSPKCQGCHRAITDRCVSVMNKNFHIECFTCAECNQPFGEDGFHEKNGQTYCKRDFFRLFAPKCNGCSQPITSNFITALGTHWHPDCFVCQHCGVSFNGASFFEHNGAPLCERHYHESRGSICSQCRGAINGRCVAAMGRKFHPEHFRCSYCNHQLTKGTFKEVDRRPFCHKCYNNTYALTPA
Function: Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping . Together with lin-8, might be required for myofilament organization in the body wall muscles . Sequence Mass (Da): 46453 Sequence Length: 413 Domain: LIM zinc-binding domains 1-4 are sufficient for the localization to dense bodies, adhesion plaques and M lines in body wall muscles. Subcellular Location: Cell junction
Q58CY6
MSTVDLARVGACVLKHAVTGEAVELRNLWQEQACVVAGLRRFGCMVCRWIARDLSNLKGLLDQHGVRLVGVGPEALGLQEFLDGGYFAGELYLDESKQFYKELGFKRYNSLSILPAALGKPVREVAAKAKAVGIQGNLSGDLLQSGGLLVVAKGGDKVLLHFVQKSPGDYAPLESILQALGISAEVGPSELPQCDEEACSR
Function: Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). Catalytic Activity: [thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha Sequence Mass (Da): 21497 Sequence Length: 201 Subcellular Location: Cytoplasm EC: 1.11.1.20
Q49Y42
MKVDLNCDLGEAFGNYSFGGDNQIIPLITSANIACGFHAGDQHVMNDTIKLAKDNGIGIGAHPGLPDLQGFGRRNMDLSPEEVYDIVVYQLGALNGFCRIHDVKINHVKPHGALYQMGARDKVIAHAIAKAVYDFDPTLIYVGLSNTLLISEAQALGLSTASEVFADRRYEDDGQLVSRKEADALITNTDEAIKQVINMVKFQKVITKNNNTIDIKADTICVHGDGAHAIEFVTQIREQLTKEGISITRLGG
Function: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Catalytic Activity: 5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 27408 Sequence Length: 252 EC: 3.5.2.9
Q9RL45
MIDLNADLGEGFGRWTLTDDDALLSVVTSANVACGFHAGDPSVMRRVCDLAAERGVRIGAQVSYRDLAGFGRRAMDVPSDELAAEVAYQIGALRVFAEAAGAPVAYVKPHGALYNRTVHDEGQARAVVAGVRLAGGALPVLGLPGSRLLTAAAEAGLTGVPEAFADRAYTAEGSLVPRSEAGSVVTDEDAVVRRALAFAVEGSVEAVDGTAVAVAARSLCVHGDTPNAARIAARVREALETAGVGIGAFA
Function: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Catalytic Activity: 5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 25511 Sequence Length: 250 EC: 3.5.2.9
Q53WG6
MKVDLNADAGESYGAFAYGHDREIFPLVSSANLACGFHGGSPGRILEAVRLAKAHGVAVGAHPGFPDLVGFGRREMALSPEEVYADVLYQIGALSAFLKAEGLPLHHVKPHGALYLKACRDRETARAIALAVKAFDPGLPLVVLPGTVYEEEARKAGLRVVLEAFPERAYLRSGQLAPRSMPGSWITDPEEAARRALRMVLEGKVEALDGGEVAVRADTLCIHGDNPNAPEVARAVREALEQAGVEVRAF
Function: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Catalytic Activity: 5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 26725 Sequence Length: 250 EC: 3.5.2.9
C4LFU8
MAQVDLNCDMGESFGIYQMGTDTQIMPLVSSANIACGFHAGDPSVMRKTLEAAVAQGVALGAHPGLPDLVGFGRRNMQVSAQEAYDMVVYQVGALAGFAKAAGVSLHHVKPHGALYNMAAKDKALADAIARAVRDIDASLVLYGLAGSQLIQAGKNAGLRVASEVFADRTYQADGSLTSRSQPNALLQSDEEAVQQVLTMVTEKRVKAVTGEWVSLDADTICIHGDGAHALSFATKVRAALLQAGVEIKAM
Function: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Catalytic Activity: 5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 26299 Sequence Length: 251 EC: 3.5.2.9
A5EZN1
MSKRTIQLNCDMGESFGVWTMGADEEVMPWIDMANIACGFHASDPHVMSRTIDLALEHEVMIGAHPSYPDLQGFGRRSLAMNEQEVSEIILYQVGALKALCESKNGQLSYVKPHGALYNDMMSDPSIFRAVVDAVSCFNLPLMVLASANNQDYLDIADRFDVPLLFEAFADRTYLANGKLTPRSQPNAVLSSEEAILNQVRQIARYGKVTSSDGFVIPIEADTLCVHGDNPNAVSLIARIRAALDE
Function: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Catalytic Activity: 5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 27057 Sequence Length: 246 EC: 3.5.2.9
Q7ME92
MNKQRVTLNCDMGESFGNWKMGSDELVMPWVDMANIACGFHASDPSVMSKTVALAKHYKVKIGAHPGYQDLVGFGRRSIPHTPAQISEIVLYQVGALKAVCQYHDVPLHYVKPHGALYNDMMESEAIFRAICEAVSIFGIPLMILATSDNQRYLDIADIYDVPLLFEAFADRQYQEDGKLTPRSQANAVYHQPEDIYNQALQIATYGSVNTANGTRLSLEADTICVHGDNPESITLVQRISQAIAKM
Function: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Catalytic Activity: 5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate Sequence Mass (Da): 27412 Sequence Length: 247 EC: 3.5.2.9