ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q186F4
MYNLIKDVKKLNPLVIHYTNNVTINDCANVTLAVGASPLMSFSYEEVEEMVSVANSVVINIGTMNSNMLDLFLLAGKAANKYNKPVVLDPVGVFASKARAELTSRLLNEVKFSVVKGNVSEIKFIGGFNVRGKGVDSFDEEEDSTEIIRKIAEKLECVVVATGKIDIITNGKGTYKINNGTDKLKGITGTGCMTASLIASFMAVTENILEAATMGVLTMSLSGELANLNNPPIGTFKENLMNAIYQMDIDALSKNSNIEFLN
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 28291 Sequence Length: 262 Pathway: Cofactor biosynthesis; thiamine diphos...
A0Q299
MLENICINFKKVKEKTPLVHSITNYVTINDCANMLLAYGASPAMVESFDESYDFAKLASCIYINLGTLTREQEQSILMVCISAKNNNIPVVLDPVACGAVPHKIALIEKLFEIGRIDIIKGNIGEIKSLAGYNAKTRGVDSIDNGNDSIDACISLAKKYKCIVAATGVKDIVTDGKRTALIENGSKMLTLITGAGCMVGALTAATAGVEDDKFIATITSILSMNIAAEHTEKEVIGPGSFKVKLIDNIYLLKENHLRKEGKIKWI
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 28656 Sequence Length: 265 Pathway: Cofactor biosynthesis; thiamine diphos...
Q0TQV3
MEVLKRENPLIHMITNYVTVNDLAQVTINYGGLPLMATHHDELKEITKMANGLLVNIGTLEPYQMESSMISMKIAKEKGIPSVLDPVGVQASKLRKDFAKKLILEGEPSLIKGNLAEIKTLIGETSNSIGIDSFDDSLSENTKNKIKEYARERNLIVVVSGVVDFITNGEESASVKNGTYKMSKITGTGCMLGALLTLALSFYDHKDLRFKEVVKAVSTWGICGELAEERLREKEGLMTFKHNLLDELSIINDETIKEREKVIYD
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 29495 Sequence Length: 265 Pathway: Cofactor biosynthesis; thiamine diphos...
Q8E093
MYLEQLKEVNPLTICITNNVVKNFTANGLLALGASPAMSECIEDLEDLLKVADALLINIGTLTKESWQLYQEAIKIANKNQVPVVLDPVAAGASRFRLEVSLDLLKNYSISLLTGNGSEIAALIGEKQASKGADGGKVADLESIAVKANQVFDVPVVVTGETDAIAVRGEVRLLQNGSPLMPLVTGTGCLLGAVLAAFIGSSDRSDDLACLTEAMTVYNVAGEIAEKVAKGKGVGSFQVAFLDALSQMKSEMIMDK
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 26959 Sequence Length: 256 Pathway: Cofactor biosynthesis; thiamine diphos...
Q2LWX9
MQITPENTWAAVKAIRSRAPLIHNITNYVVMNSTANALLALGASPVMAHAQEEVEEMVGIAQALVVNIGTLSPSWVRAMASAALKAADRGIPIILDPVGAGATAYRTRTAFQLLETVSPTIIRGNASEILAFESVETMETRGVDSTELSQNAVDAGRRLNDSYGSTVCISGETDFIIGDRAILGIRNGHPLMTRVTGLGCTASALCGAFAAVNSSFTLAAAQAMAVMGIAGEMAAEISPGPGSLQLHFLDILYRLTEEDIARRLRIVAGE
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 28368 Sequence Length: 270 Pathway: Cofactor biosynthesis; thiamine diphos...
Q0AZ87
MLKYCAEIWDEVRNRRPLVHCITNYVTVNDVANIILAAGASPAMVEYPAEASGFAPLASVLYFNLGTLTGEQEAAMLEGRWAAASRDVPLILDPVACGVIGRKVDLIERIKSLGKIQVLKGNIAEIKSLAGLAGKAQGVDSLDTGEGLEEACLQLAVKDKLIAVATGEVDIVAEENRYARIFNGTPLFQNITGAGCMAGGVIAACVGAAPEEAWLASITGLLAFNLAGERAASQAGNRPGTFRTLLFDELFVLRGEELMKEGRLEW
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 28278 Sequence Length: 266 Pathway: Cofactor biosynthesis; thiamine diphos...
B0KBA7
MKKELLKILREKKPLVHHITNIVTVNDCANITLAIGALPVMAHALEEVEEMVSAADALVLNIGTLTNEQVEAMIKAGKAANRLKVPVILDPVGAGATKLRTQSSKKILEEVKISVIKGNSAEISILAGKGGKIRGVESQSGADDISEAAKDLANAYNVVVAVSGVTDIITDGKRIAYVKNGHPMMGTVTGTGCMLTSVVASFCGVCEDYFAATVEAFVAFGIAGERAAQSSNVKGPGSFKVTFFDEIYNLTPEIIEKDKKVEYE
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 27951 Sequence Length: 264 Pathway: Cofactor biosynthesis; thiamine diphos...
B7VS66
MLTEQIIQSLRAVREQKPLVVNITNYVVMNNTANALLAIGASPIMAHSKQELAEMMSFSGALVINIGTLDSVWTPRMCFAVEQANANNKVVVLDPVGCGASTLRTETSREIARLADKLIIRGNASEIIALAGEQAQSKGVDALDSSDAALGAAQCLVAEYGANVVISGETDYVVTKDSVVTLNNGHPMMPYVTGMGCTLTALTGAFAAVGDESGLAAAAVLGVVGEISAESSRGPGSLQMNLLDELYQLDEETLIQRLKVQ
Function: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). Catalytic Activity: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Sequence Mass (Da): 27369 Sequence Length: 261 Pathway: Cofactor biosynthesis; thiamine diphos...
O34664
MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGIIPVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGITGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPFSEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD
Function: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Catalytic Activity: ATP + thiamine = AMP + H(+) + thiamine diphosphate Sequence Mass (Da): 24099 Sequence Length: 214 Pathway: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1. EC: 2.7.6....
O26949
MMIMEIENVRRALEMISSAEDFGILIPEVRSNIVMARSNPCGPEDVVAVPGRITEFQGRAFACRDPEYGASSHMARFIIALNEHLPGRRSALNIKFDESIISICEDMGLVVSSYDRSREPDSVRDTEGGSIPWGVEEALRNSESPPDVIYHRGAWGKEPMIVLTGRDAVEVAELAIKILRKYKSLKGDTR
Function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Catalytic Activity: 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine ...
Q9KP42
MLALDKVRYEYEHEWFEFDLNVADGDIVALMGPSGAGKSTLLSLVAGFIEPVSGSIKVNDQSVLGLAPYQRPFSMLFQEHNLFAHLTVRENIGLGLHPGLKLNAEQKQQVVDAAQQVGIADYLDRLPEQLSGGQRQRVALARCFVQPNPIWLLDEPFSALDPLLREEMLALVKQLASERQRTVVMVTHHLSDARAIASQIAFLSQGKVKVVSDCQAVTAQHPHPELAQFVAAALNEPK
Function: Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system. Catalytic Activity: ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in) Location Topology: Peripheral membrane protein Sequence Mass (Da): 26238 Sequence Length: 238 S...
Q8DE95
MLTLQQVHYYYHQDLFAFDLEVEAGSIVALMGPSGAGKSTLLALLAGFIAPQSGQMALDGRLLNTLSPAQRPFSMLFQEHNLFAHLTVRDNIALGLHPGLKLTSQQQKQVEQAAKQVGIEAYLDRLPEQLSGGQRQRVALARCFVQPNPIWLLDEPFSALDPVLRDEMLSLVKQLAQERAITVLMVTHHLSDARAIASHFAYIDKGTIAAHGPIASLNEKHSHPELVEFFQAAV
Function: Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system. Catalytic Activity: ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in) Location Topology: Peripheral membrane protein Sequence Mass (Da): 25793 Sequence Length: 234 S...
O31617
MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKERYHEVELCDRDVIEIVHFVGGG
Function: Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) by ThiF, then thiocarboxylated (-COSH) by ThiI. Sequence Mass (Da): 7626 Sequence Length: 66 Pathway: Cofactor biosynthesis; th...
O32583
MQILFNDQAMQCAAGQTVHELLEQLDQRQAGAALAINQQIVPREQWAQHIVQDGDQILLFQVIAGG
Function: Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) by ThiF, then thiocarboxylated (-COSH) by ThiI. Sequence Mass (Da): 7311 Sequence Length: 66 Pathway: Cofactor biosynthesis; th...
Q72KL7
MVWLNGEPRPLEGKTLKEVLEEMGVELKGVAVLLNEEAFLGLEVPDRPLRDGDVVEVVALMQGG
Function: Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) by TtuC, then thiocarboxylated (-COSH) by the cysteine desulfurases IscS or SufS. Sequence Mass (Da): 6986 Sequence Length: 64 ...
O32074
MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMIPIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFASSVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTYNATYMVPSFIICAIVLCLLFMTAPRLLKSDKA
Function: Probably a thiamine-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracyt...
A2RI47
MSNSKFNVRLLTEIAFMAALAFIISLIPNTVYGWIIVEIACIPILLLSLRRGLTAGLVGGLIWGILSMITGHAYILSLSQAFLEYLVAPVSLGIAGLFRQKTAPLKLAPVLLGTFVAVLLKYFFHFIAGIIFWSQYAWKGWGAVAYSLAVNGISGILTAIAAFVILIIFVKKFPKLFIHSNY
Function: Probably a thiamine-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracyt...
Q037U3
MQQHKQLVVILETAIIAAFAMALTYIPHTTGVSAIELNYGLIPIAVLAMRRGLVPAAWAGFVWGILDLILRGIGGGSVLNPLQGILEYPIAFTLVGLMGLTFASFQKAVRGSEKVKASGYAFAGIIIGTFAKYFIHFIAGVVFWGAYAPKGTNVWVYSLIVNGGSALFSTVLTIVVVGVLLTVAPQLFVAKDGKSFSTKAA
Function: Thiamine-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic so...
P42461
MSISRTVFGIAATAALSAALVACSPPHQQDSPVQRTNEILTTSQNPTSASSTSTSSATTTSSAPVEEDVEIVVSPAALVDGEQVTFEISGLDPEGGYYAAICDSVANPGNPVPSCTGEMADFTSQAWLSNSQPGATVEIAEDGTATVELEATATGTGLDCTTQACVAKVFGDHTEGFRDVAEVPVTFAAA
Function: Is necessary for biosynthesis of the 4-methyl-5-(beta-hydroxyethyl)thiazol component from which thiamine is formed. Location Topology: Lipid-anchor Sequence Mass (Da): 19251 Sequence Length: 190 Subcellular Location: Cell membrane
P04990
MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIELHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCIVIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIEGQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEGAAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIARVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKD...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Mass (Da): 37464 Sequence Length: 352 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-t...
Q89AR5
MKLYNLKKKQDQVNFSKAVKLGLGKNQGLFFPKELPILTKEQLYKLLKMDFLTRSSKILSMFIGDEIHYSELTKRIKNAFSFTTPKIVSISKNIACFELFHGPTLAFKDFGARFMAQILSFLNHDKNDTITILTATSGDTGAAVAHAFFKMKNVRVIILYPKGKISELQEKLFCTLGENIITIAVNGSFDECQKLVKQAFNDDQLRIETGLNSANSINISRLLAQICYYFEAFALLTKKQQKNLVISVPCGNFGNLTAGLLAKALGLPIKSFIASTNSNDTVPRFLKTGFWKPNNTVSTISNAMDISQPNNWPRVEELFK...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Mass (Da): 48632 Sequence Length: 430 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-t...
P23669
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAITARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRGREGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYYVSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDI...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Mass (Da): 52931 Sequence Length: 481 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-t...
P00934
MKLYNLKDHNEQVSFAQAVTQGLGKNQGLFFPHDLPEFSLTEIDEMLKLDFVTRSAKILSAFIGDEIPQEILEERVRAAFAFPAPVANVESDVGCLELFHGPTLAFKDFGGRFMAQMLTHIAGDKPVTILTATSGDTGAAVAHAFYGLPNVKVVILYPRGKISPLQEKLFCTLGGNIETVAIDGDFDACQALVKQAFDDEELKVALGLNSANSINISRLLAQICYYFEAVAQLPQETRNQLVVSVPSGNFGDLTAGLLAKSLGLPVKRFIAATNVNDTVPRFLHDGQWSPKATQATLSNAMDVSQPNNWPRVEELFRRKI...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L-serine and 3-chloroalanine into pyruvate. Is also able to rapidly con...
Q9K7E3
MSQWRGLLQEYKEFLPVTEETPLLTLGEGNTPLIPLENLSKEWGVKAYVKYEGANPTGSFKDRGMVMAVAKAKEEGSRTIICASTGNTSAAAAAYGARAGLRCIVVIPEGKIALGKLAQAVMYGAEVLEIKGNFDHALDIVRSISEKEPITLVNSVNPYRIEGQKTSAFEICDALGQAPDVLAIPVGNAGNITAYWKGFKEYHEKKGTGLPQMRGFEAEGAAAIVRNQVIEEPETIATAIRIGNPASWTYAVEAAAESNGKIDEVTDEEILAAYQLLAQKEGVFAEPASCASIAGLRKQIASGEIKKGSTVVCVLTGNGL...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Mass (Da): 37665 Sequence Length: 354 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-t...
O24924
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNDLVECVFERLGLEIPKNLLASALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLYPKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNEALKACQLKLSVANSVNFGRIAFQIVYHIWGFLELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDIL...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Mass (Da): 54707 Sequence Length: 486 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-t...
Q8TQD4
MYHLKCIECGAEYSRDEVIYTCSKCDGLLDVIYDYSSIKIDMEKLKTECPSVWKYAKLLPVEREPVTIQEGGTPLYKCDRLAEKIGIKKLYVKHEGMNPTGSFKDRGMTVGVTKALELGMNTVACASTGNTSAALAIYGAKAGIPVVVLLPAGKVALGKVAQALMHGAKVLSIRGNFDDALALVRTLCSQEKIYLLNSINPYRLEGQKTIGFEIADQLDFKVPDRIVLPVGNAGNITAIYKGFREFKILGITDSLPKMTGIQAEGSCPIVKAIKSGAPAITPEENPETVATAIRIGNPVNATKALSAIRESGGTAESVTD...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Does not catalyze the conversion of O-acetyl-L-homoserine into threonine. Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Mass (Da): 43285 Sequence L...
A0R220
MSAAKAAVHQPWPGLIEAYRDRLPIGDDWTTVTLLEGGTPLIHAKRISELTGCTVHLKVEGLNPTGSFKDRGMTVAVTESLARGQQAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQVDGNFDDCLELARKLTADFPTIALVNSVNPYRIEGQKTAAFEIVDALGTAPDVHALPVGNAGNITAYWKGYSEYHRDGVSDRLPRMLGTQAAGAAPLVTGAPVKDPETIATAIRIGSPASWNSAVEAQQQSDGRFLAATDEEILAAYHLVARTEGVFVEPASAASIAGLLKSVEDGWVKRGST...
Function: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Mass (Da): 37443 Sequence Length: 360 Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-t...
I2C644
MGYRNGNYAAFYVSEPFSESSLGANATKDFVSYNMLRAWKGKDNNYPFNDSHDKTYNVRDGSDWEKTLKPRLRKRLDQSKNIIFFLSKHTENSKALREEIDYGINVKGLPVIVVYPELSEKSDIIDCTTKVFRSEVVNLWSRVPVFKDSMLKVPTIHIPYKKDQIKKALENKDFMINSKISAGSVYFYPC
Function: TIR-like domain-containing component of the Thoeris antiviral defense system, composed of ThsA and ThsB. Expression of ThsA and ThsB in B.subtilis (strain BEST7003) confers resistance to phages SBSphiC, SBSphiJ and SPO1 . Phage infection activates this protein, generating a signal molecule that in turn activa...
Q9NS62
MKPMLKDFSNLLLVVLCDYVLGEAEYLLLREPGHVALSNDTVYVDFQYFDGANGTLRNVSVLLLEANTNQTVTTKYLLTNQSQGTLKFECFYFKEAGDYWFTMTPEATDNSTPFPWWEKSAFLKVEWPVFHVDLNRSAKAAEGTFQVGLFTSQPLCPFPVDKPNIVVDVIFTNSLPEARRNSRQPLEIRTSKRTELAQGQWVEFGCAPLGPEAYVTVVLKLLGRDSVITSTGPIDLAQKFGYKLVMVPELTCESGVEVTVLPPPCTFVQGVVTVFKEAPRYPGKRTIHLAENSLPLGERRTIFNCTLFDMGKNKYCFDFG...
Function: Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 94584 Sequence Length: 852 Subcellular Location: Endosome membrane
Q2HJE9
MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGMRHRLRGSVNAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSVPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPGQLPSKEGTPGPGYPSYQQYH
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 18321 Sequence Length: 172 Subcellular Location: Mitochondrion inner membrane
O60830
MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGIRHRLRGSANAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSGPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPSQLPPKDGTPAPGYPSYQQYH
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. PTM: Forms one disulfide bond. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 18273 Sequence Length: 172 Subcellular Location:...
Q9VGA2
MEYNRQPCPIRIVEDCGCAFMMGTIGGSLFEFLKGFRNAPTGLQRRLYGGIDLVKMRTPSIAGSFAVWGATFSTVDCALVHYRQREDAWNSILSGAATGGILAARNGIRAMANSALVGCLVLAMIEGAGAAVATINAADKGAGIVIKPQRAQWEAILETIDPKRASSTQDFALAEFERVLDKCRASREPNLLQDIPVKSHERDSKQKPFYSLLDLVKLSQMF
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 24159 Sequence Length: 222 Subcellular Location: Mitochondrion inner membrane
Q8GZ79
MITGYSTPSAHVLMSSRAFKSSSYRAAAGQTQHYLARSSLPVVKNSWGSPPSPFNELPRVSRGVPLSYLSASSSLLLNGEQGSLSGTLPVLPVRRKTLLTPRASKDVPSSFRFPPMTKKPQWWWRTLACLPYLMPLHETWMYAETAYHLHPFLEDFEFLTYPFLGAIGRLPSWFLMAYFFVAYLGIVRRKEWPHFFRFHVVMGMLLEIALQVIGTVSKWMPLGVYWGKFGMHFWTAVAFAYLFTVLESIRCALAGMYADIPFVCDAAYIQIPYD
Function: Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope. Seems to be specific for photosynthesis-related pre-proteins. Partially redundant with TIC20-IV, but not with TIC20-II or TIC20-V. Location...
O82251
MASLCLSLHQTLTNPLSAPRCRPLSLSFPGSSTFSIRPSSRRATALTTRASYTPTPATERVISIASYALPFFNSLQYGRFLFAQYPRLGLLFEPIFPILNLYRSVPYASFVAFFGLYLGVVRNTSFSRYVRFNAMQAVTLDVLLAVPVLLTRILDPGQGGGFGMKAMMWGHTGVFVFSFMCFVYGVVSSLLGKTPYIPFVADAAGRQL
Function: May be involved in protein precursor import into chloroplasts. Not redundant with TIC20-I, TIC20-IV or TIC20-V. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 22912 Sequence Length: 208 Subcellular Location: Plastid
Q9ZQZ9
MQGLAATTTNRGSLTFLAPRNHSPISKKFVNPRVFFPNVDSSAKLRLSASSISRRCPREIAPLSATASVDFAAAATSSNQLFANGLPPLAPGLRRHRRPIEPARVAKDDFFKIKLPKIAERPEWWWRTLACVPYLISLQISDVGFYVQPFLEKHDAIGDMIYFIPGAINRWPTWFFMVYCYLGYMWVVKNKELPHYLRFHMMMGMLLETALQVIWCTSNFFPLIHFKGRFGMYYWMAIGFTYICLLLECIRCALAGVYAQIPFMTDAASIHTLFNLGGFQRPLR
Function: Involved in protein precursor import into chloroplasts. Partially redundant with TIC20-I, but not with TIC20-II or TIC20-V. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32520 Sequence Length: 284 Subcellular Location: Plastid
Q9FM67
MAIISQFFAPLPSLTGTLTLTGRSFLPLNLDTQFPKPRLSRDRAATLVLQSKGDDSVDASDRIISAVCYFYPFFDGIQYGKFIITQYQPFQILIQPLFPAIRAFKSFPFNGFLIFITLYFVVVRNPNFSRYVRFNTMQAIVLDVLLIFPDLLERSFNPRDGFGLDVVMSLDSTVFLFLLVSLIYGFSACLFGLTPRLPLVAEAADRQVL
Function: May be involved in protein precursor import into chloroplasts. Not redundant with TIC20-I, TIC20-II or TIC20-IV. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 23652 Sequence Length: 209 Subcellular Location: Plastid
Q568N3
MCTAVRQDLSLKCGGTDVKQPGDSQPGHLRALLGFTLPSVYASDSSTQILPKHIGKPEFPDTGWDRIKDLFYNVEGQYTEELRNVVKSGIASAIVGMIYGGLPGARHARQRFIQCSQAEIYRNRVDAVRAAHNAAIRGFLRFGWRWSWRVAAFVTLFNTVNTGLTVYRDQNALSHFAVSGAVTGGVFRLNLGLRGLLSGTIIGVILGFPAGVLILGLQNLGGETMRDKRRRERRELHELRVTEWNARLKVTDDLIGEMSSLKHQDSEIDLQQVEELLSQPRNGNAAKGPYNQ
Function: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32372 Sequence Length: 292 Subcellular Location: Mi...
Q9NPL8
MEVPPPAPRSFLCRALCLFPRVFAAEAVTADSEVLEERQKRLPYVPEPYYPESGWDRLRELFGKDEQQRISKDLANICKTAATAGIIGWVYGGIPAFIHAKQQYIEQSQAEIYHNRFDAVQSAHRAATRGFIRYGWRWGWRTAVFVTIFNTVNTSLNVYRNKDALSHFVIAGAVTGSLFRINVGLRGLVAGGIIGALLGTPVGGLLMAFQKYSGETVQERKQKDRKALHELKLEEWKGRLQVTEHLPEKIESSLQEDEPENDAKKIEALLNLPRNPSVIDKQDKD
Function: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32178 Sequence Length: 285 Subcellular Location: Mitochondrion memb...
Q5XK94
MAQSDPPKSPDPPLPTSIRNPQTPESGWDRIRELFQPNEQGHYPEEVGSIVKSAVTGALLGGIYGGLPAARHSKERYIQQSQAQIYQHRVEAVRSAHNAALRGFIRYGWRWGWRVAAFVTIFNSVSTGLTVYRDKLALSHYAAAGAVTGGLFRLNLGLVGLLSGSLIGAALGVPAGALISGLQSISGESIREKKRRERQELYENKVQEWSARLQVTDEVLEEMETSQQDPLEQQVEKIQELLQLPRNPAVSPKEGR
Function: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 28246 Sequence Length: 256 Subcellular Location: Mi...
O73792
QLLQFAADVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRMQEARKAYVNMALFENFTYAGIDATAEEA
Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Catalytic Activity: ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein] Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 21190 Sequence Lengt...
Q13263
MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKV...
Function: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target...
Q1DAT1
MKVQVEELSPIEKKLSIEVDNARVAEELSRAYSNLGRQVRLPGFRQGKVPRRILEQRFRDQVEDEVIQRVVQSAYVEAIREHNVEVVATPQVTNSGLKPNTPFTFEARVEVKPKVEAKDYVELPLTKSDTAVTDEQVNEQLERMRQSMARLEPVTDRDTAASGDYVTVDFDATVDGQPFAGSKAEGITVQVQPGELVESKIAALEGVKVGESKDIDYAFPQEYRVEEVRGKTARFHITLKGVQKEIVPELNDDFAKQSGVAQSIDELRTKLREDMEKARKSQVEGEEREALMKALLERNTFDVPRAMVERAMDSMLRGAL...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 48091 Sequence Length: 4...
B2A157
MSSTWEKIDKNKIKLSVEVDENRVEDALEQAYKKVVKQVEIPGFRKGKVPRKILENRFGPEVLYEDAIEILVPEAYQEALEEHEIEPVDQPEIDIDQMEKGQPLKFNATVEVKPEVELGTYKGLEVEKEKVEVTEEDVENELKQMQEQHAEYEDVEDGEAENGDRLVIDFEGYVDGEPIEGGQAENHNIELGSNQFIPGFEEQLVGSKPGEEKEVKVTFPEDYQNEELKGKEATFNVKVKEIKKKNLLPIDDEFAKDVSDFDTLEEFKNDIRNRLEEEAERAAEQQVEEQVVTKALENAEVEIPQPMIDQEVDNMLKEFE...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 51227 Sequence Length: 4...
Q9JZ37
MMSVTVETLENLERKVVLSLPWSEINAETDKKLKQTQRRAKIDGFRPGKAPLKMIAQMYGASAQNDVINELVQRRFYDVAVAQELKVAGFPRFEGVEEQDDKESFKVAAIFEVFPEVVIGDLSAQEVEKVTASVGDAEVDQTVEILRKQRTRFNHVEREARNGDRVIIDFEGKIDGEPFAGGASKNYAFVLGASQMLPEFEAGVVGMKAGESKDVTVNFPEDYHGKDVAGKTAVFTITLNNVSEATLPEVDADFAKALGIADGDVAKMREEVQKNVSREVERRVNEQTKESVMNALLKAVELKAPVALVNEEAARLANEM...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 48325 Se...
Q0AJI1
MQTQEEASNPLERNIELSVSREKVEAEVGQRLKRLAPKIKIQGFRPGKVPMKIVAQQYGHQIEHEVLGELLQQQFSESINRENYRIAGVPNFESRNPGTDNSNYEFRATFEIYPNIELGDLNSITINKPVLQIGDVEIQKTLEVLRKQRTNYESVDRPAQTGDRVNINYQGSLDGKNFAGGQADNYSVILGNGHLLEDFEASILGMSTGQEKTFDMTFPEDYSGKEVAGKKVTFTITLNKVEAPKLPDVDGEFAKSLGIEDGNVEKMQSEIKANLQRETTQRIRVKLKEQVMQSLLDKISVDIPKILVQQEIDRLIEEVQ...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 49761 Sequence Length: 4...
Q82Y58
MQTQGEASNPLERNIELSVSREKVEAEVGVRLKRLAPKVKVQGFRPGKVPLKIVAQQYGHQVEHEVLGELLQQQFNDAVNQENYRVAGIPGFESRNSDANGATSYEFRATFEIYPDIELGDLSSITVNKPVLQIGDAEIQKTLDILRKQRATYEPTDRPAQTGDRVTIDYRGVLDGEGFPGGQADDYSVILGNGHLLEDFESSILGMTAGQEKTFDMTFPADYPGKDVAGKKVSFTIRLNKLEAPKLPEVDGEFAKSLGVAEGDIDKMRSEIKANLQREISQRIRTKLKEQVMQSLLDKVLIQVPKVLIRQEADRLAEEM...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 49398 Sequence Length: 4...
Q3JAJ7
MQVTVEATGELERRLTITLPGSDFESKVQERLRSMVPRIKMDGFRPGKVPYKVVERRYGSAVRQEVSDEFVRDSFRDAIKQESLRPAGMPQIEPPQLEAGESFAYTVTFEVLPEIESVKLEGIKIKQPRAEVTDKDIEGVLKKLQEQHIEWEPMERPAQEADGVTITYHGSIEGKPFPGGSKENFFVILGKGTTLKEFEEHLIGVNKGQELTFEITFPEHYGNQELAGKKASFAVKVISVTAPRLPEINEDFAEKLGVKEGGVAALRQEIKASMTRNLEQAVRDRVREQIMDGLLVANPTTLPISLVKEETSILLEQAKN...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 50196 Sequence Length: 4...
A6Q1C0
MEINAQKLNEANATVEAKIAKQDVEKKEEKIAKELAKTMNIPGFRKGKVPPAVIKKRYGDKLAQDAEAELVREALDQALEELGIEKEAMLGEPRFAKYEKGEEVIEMVLEIGVRPNIDITGYEEVIPEYEEPQVSDEEVEKRIEELADAMAQFKEIEEDRPAKEGDLVVIDFKGTLEDGSEIEGGSAQNFELRLGSGQFIPGFEEQVEGMKKGETKTIEVTFPEDYPNKELAGKKANFEVTLHTIKEKEKINIDDELAKKMLQKEDATLDELKEEVRKQLKSEKLSKLYNEELKPKLVEALVEKFEFDLPKNIVDQEIDV...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 49764 Sequence Length: 4...
A6Q674
MKVEVKKIDDANVAVQGNIENKVVEANVDKLAREAGKQMKVDGFRKGKVPPHVVKKLHGDKLQQDAEGDALRSLIDLGVKEAGINTADILGEPIFKKYDKKDEGIEVEVEISLRPTIEAEGYEKAVPAFEKPEATEKEVEEKLEEIAAQQAPFEKIKRKRMVRDGDTVVIDFEGFVDGVAFEGGKAEKFSLKIGSGQFIPGFEEQIIGMKYDEEKTITVAFPEEYQSKELAGKEAEFKVKLHEIQEQVPAELNDALAQKLLQDEKATLDTLKEKLKEQIVNEKTSKIYNEELKPKIIEALVAHFDFALPNNIVEQEIDAK...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 48099 Sequence Length: 4...
Q67SK1
MKATWDKLENNWMQFEVEVDASEFSKSVEAAFRKMNRQVTIPGFRRGKAPRAVFERVYGKEALVQEAVDQILPRAYSEALEQGQIEPISQPEIEVVQAEDGKPLIFKGKVQVTPEVTLGRLSGFGIEKQVPEVTDQEVEEQLSALRERLATLVTDESGEVGQGSFAVIDFEGFIDGEPFEGGKGEGYTVEIGSGTFIPGFEEGLVGAKAGETREVTVTFPEDYHAQHLAGKQAVFKVTVHEVKKKELPELNDEFAQQVSPFKTVEELRADIKNRLSEAAAQKAEEDFRNKVVEAVADDASVEVPEVLVHDKVHDMIHDFE...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 47932 Sequence Length: 4...
Q2LTK6
MDENTVAVKVEEISPVKKKLLFDVPWEDVKRERDTIYRNFSRTAKIKGFRKGKIPRKILELHYKKHAEEETVSSLVSRLYWDALKEHDIRAISQPEIEQQGIEEEKDFSFSATVEVEPQIDPQGYLDMTLSKEEQTVTEDEVDGRLEDIRKMFGTLEEVTEDREIRKGDFVTIDFEGFIDGQNPEEMKRNDYFLEIGSNTMVPGFEDQLLGEKVGTIKEIKIIFPENYQINSNVAGKDATFKVTIKNLKEKKLPELDENFVKNFDKYESLDDLKEDVRKSLFEDHKRKTEADMSKKIMDKLLEMNDFDAPSSYVERQIFF...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 51905 Sequence Length: 4...
Q3A3X4
MNVKVEDISSIKKKLSFEISVEAVDTEFSNEYKKLSKTAKIPGFRKGKVPRSVLERQYAGHVEGQVFERLVNETFFKALVDEKINAVSAPEVVDNGPLKPGQAFTYEAEVEVRPDVEAKDYIGLDLKKENFAVEDQDVEDRLQDMLKSRAKVEVSEREVAQAGDIAVIDFEGFVDGEAFAGGKAEGHELELGSNSFIPGFEDQVVGMECGQDKDIEVAFPEDYGNEELAGKPAVFKVRLNQIKERVLPALDEEFAKEAGLESVEDLKIKIRESIEGQERDRIEKDFRERMTDALIEANEFEVPEGMIDSQIDYMLKNLQN...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 49446 Sequence Length: 4...
Q935Z3
MSIKVTQEKLPASRVGLQIEVSGEQSRQVYERTLTRLSREVRFPGFRPGKVPRPVLIQRLGETALKANAIEDLVQQSLESAIAQESIPAIGNYQLSSDFETLVAAFQPGESFSFEASVDVQPTATLAQYTGLTVEVAEVPFDANRVDNVLAEQQKQMATLVPVEGRNAAIGDVAVIDFQGILVESGEEIPGGSGTDFQIEVEEDRFIPGFISGIVGMAIEETRTVDATFPETYAQEEVAGKAAQFTITLKELKTRDLPELDDAFAQEASQYETIEELKTALTERFQAEHESEVKASKRDAILTALADQLDVEIPESLLQR...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 52218 Sequence Length: 4...
A0LEF2
MNVSVVDLSENQKKLQVEIPPEKVRQEIEGKYREMSRRIKIKGFRPGKVPRSIIKSYYGKTIEQEVSSQFIQETFPEALKETDLKPLVEADVSETHFNDSGSFSYTAIVDVCPPFELEGYRGLEIRKPSIDVADEQVDSELQRLREQHAELRTLETERPAREGDVAVIDFTPSVDGKVFEKGKSADYMAEIGKKAVHPDFDANLIGRRAGETVSFEVDYPENAPMREIAGKRVLFEVTVKEVKEKVLPELDDDFAQAVNSRFDALDALKQTIREELLKREEYQARSDVQQQILDQLLSKVKIELSAKVIDREVDRMVGNL...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 49942 Sequence Length: 4...
Q2JQ33
MQVTQEKRPGSRVGLKIVVEADRVKRSYEKTLRQLEQNIQIPGFRKGKAPRNLVVRQVGRERILASAVDDLINEAIQQAFKEAQLTPISRFELDDEVGQLLAQFNPEADFSFSGYVEVYPEARVGQYKGLTVTATRVDVKPEQIDQLIDRWRDQRATLLPVEDRPAQLGDVVVIDFAARDAEGNPLDEMTTQDFQLELKEDNFIPGFVAGIVGMQLDETKEIAATFPDDYFRKELAGKTVTFIVCLREIKAKELPELDDAFVQEISSFQTVAELREHLQKRLEQDALRQSEENLETAILNAILETTEVDLPETLIEQETT...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 61742 Sequence Length: 5...
B1XL18
MKVIQEKLPASQVGLEIEVPADVTQKAYDDTVRKLARTVNLPGFRKGKVPKQILIQRLGPNRIKASVLEDLIDDSLKAAIAQENIEALGNFQLKSSFDDLISAYKPGEASSFKAAVDVPATVTLNSYKGLSFKAEKSEYDPADLDEFLTQKQRELATLVPVEDRAAQMGDVAIADYEGRYVNDAGEEEEDIIPGTQAEDFSLDLEEGKFIPGFVDGFVGMKPEETKKFTVTFPEDYGNEEMAGKQVSFTVTLKELKSRELPELDDEFASEATNEEFETLAAWQESLEAQLKENAEISTKNSVRRYLLEQLAANNSTELPE...
Function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 50829 Sequence Length: 4...
Q6ACP8
MRAALAAAAALPVPDAEGDHGPARPHPLAPGALVLIGLSGGADSLALAAAAAFEAPRAGFRSGAIVVDHGLQPGSAEVAAGAACQARALGLGPVLVERVRVEAAGGPEGAARAARHTAFDSAARATAAARILLAHTLDDQAETVLLGLARGSGPSSLQGMLPDTGRLLRPFLGLRRATTRAFCADSGLEPWDDPHNDDPAYTRVRVRSAVLPVLEQELGPGVAEALARTAEQLREDDQALDSLALEGAQELVSQADDGSVALEVRGLAAGPPALRQRIIRLVVSAEFGVSLSRSHTLAVAALIADWHGQGPLSLPGVRVV...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q8F9P6
MRDKISESTQKIFHAVWERIAPFHEMIQSRPAVLSYSGGKDSSILLHFYFWLWIEKKIPAPCIYHLDHSIRFNLEQEKKIFEYADSTFPFSKIFKKKNIPALSRRLGKTLEETGRAFRYKDLKKISDQYEGYIVTGHHSSDYLETILLNLIRGGGWNSLRTLGWYEKNRFRPLFAFSQDEIETILQSEFWKIFEDESNNSDEYLRNRIRSYIIPLLLREGANPDRIYKNFHRIEKPVSKIFSKKNSDHKIPSFLKIDIWVLNDLSQRERKFFIDRYLRSLNLYPTTRNFFRDLTDLLQKENSFSLENKETWFWKSTSSDL...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q8YAC7
MDDTEKRVHKYIEKHDLIRSDDKLLVAVSGGPDSLALLHFLWNSNLVPKEAISVAHLNHQLRENAAKEQRVVETFCERQGIPFYIEEVDIKSRAQSLQKGLEETARIVRYDFFEKVMAEKNINKLVLAHHADDQIETILMRLVRGSASIGWSGIQPKRELKGGQAIRPFLPITKAEIIDYAQKHELAYEIDESNTSQEYTRNRYRAQLLPFLKQENPAVYSHFERFSEETSEDFQFLEALASDLLKKNLIKNGKQTTLLLSSFKNEANPLQRRAIHLLLRYLYNEDASFITVNHIYQIIQMIQSDNPSSSIDLPNKLIAN...
Cofactor: Binds 2 magnesium ions per subunit. One of the ions does not make direct protein contacts. Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the ami...
Q8EWQ7
MKHKYLIAVSGGPDSMALLNKKRHLVEAVCHVNYHDREDSDNDEKIVRDYCKKYNLKLFVFDTHKDDVSKYKDINNLQTWYREIRYDFFEKISQELGIKKILIAHQKNDFLESAYMSLNKNKKNLFLGIRRKSKFRSLILIRPLLNKTKKSLEQYCRSKNIEFVIDYTNFWDRYSRNVVRKMMAEWDKKTFQKFYLKVKWFNLKNMFFIKLLDSKFNNWIKQDFDINYFLKIKNNYKESLIYLFLNHIGIKPNENKIEQIIEFINKNKNGSVKKYRLKENQFIEIKNKKILYSIC
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q6F0E4
MERFKLNTTLSYLVAVSGGPDSMFMLNELIKMNIKEIVVCHVNYNFREDSWKDQKLVEDFCLKNNLKLEKLIINQDYSKLKENFESWARNIRYDFFVEISKKYNIQNVLIAHNRNDLVETFLLQQDRKGYVKHYGLNKTSTYKEITIVRPMLNILKSEILKSLKEENIAFVIDSTNEDKKYKRNKIRANLSESTFNDFEETIKKLNKKLEIINLEVNWYVNNNMSADELKINKNLQDQDLEFIQRTIYKWLEVIKKDFVIQNRRNKTIFEIAKNIKVSEKVFWEINIGEYSIIKDYENLFIIETKAIQPKTILIKSKEDL...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q601M6
MQIKIKSKEKYLIGVSGGSDSMFLLNKYKNQDVIVAHINYNLRPEAIFETLLVSKFCQKYNLELKILSFDSFKIKKNLQSGLRLGRYQFFEKIYKEFNCTKLLVGHHRDDFLETVFLQKKQKKIVTFWGIHKKNNLFNMEILRPFLYWRTKKQIIRICQQKKIPYLDDQSNFTGKYQRNQIRFLLEKKSDFSLFFLFLFYYLINIFKLIILKNQKKILQNWQKTGYNINFFKKIKIKSKIIFLFVNQNFDNVKLTRGKINEIINFICGKSTSGAFLLKKNNYIIKKKWKILPKSSKI
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q9MUR3
MIFLYSKIHKDIIIHNLLKKNDRILIAASGGQDSISLIKILVELQPQWNWDLGIVNCDHSWNQSSRKGSSQIAQIAQLLNIDFYQIVTCHQLINEEKAREWRYQKIEDIAFSNKYNVIVTAHNASDRIETFFFNLLRGTSITGVQSLLWTRSLSSGINIVRPLLNTTRFELKNFVKEIHLPLWPDTSNQSLFFKRNRIRKQLLPYLRKYFNPKVDKVIAQFAEIIHDESFYMENVTQIIEKQLFFGSKNIQQEFIENLPIAIERRIIKKMIEKKLSENHCNFLNIEQIRFFFQKNRKKYSLLECIHFFSN
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q607F5
MRLSLDSFRAGLHPGSTYRVAFSGGLDSAVLLDLMCQVRRVSGIGVRAIHVHHGIQPEADAWSRHCAAVADRYGVALDILQIDGRSRPGDSPEAAARTARYHSLEASLDPGDILVTAQHLDDQAETLLLQLLRGAGLAGLAAMPNAVPFGAGILHRPLLRFGRRDILAYAQERGLSWIEDPSNRDERYDRNFIRRRILPQLAGRWPAVAANLTRSAGHCAEAAGLLDRLADTLMAAATAADEPGTLVLEIVQRLQPDEQRLLLRRWIHKRGLRAPPAKLLERIRKEVVETAGDRTPMIAWAEGTVRRYRHRLHLLPPSAD...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
B8IP16
MTEAARPLDREEFARRLDRWLGPGAAGGVVLAVSGGPDSTALMGGAARLPPLVPVMVATVDHGLRPEAAAEAEAVARLAGRLGLPHRILAWTGPKPRTRLQEAARAARYRLLLDLAREQGAAALLTAHTLDDQAETVLMRLCAGSGPAGLGGIEPVRHLGGLALVRPFLDLPKARLVATCAAEGWPFVVDPGNADARFARGRLRRVMPHLAAEGLTAARLARLAERLRRNEAALAAAADAALDALARPGARPGGMMLDARGLAVLPEAVALRVLARAIATVVGGNARPARLERLEDVLFGRLLPAIAAGGRLRCTLGGAL...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
A2SIL9
MSGSRATAATTTPRSAEPPRGLAVAYSGGRDSTALLHATLIAARDSGLTVHALHVHHGLSARADAWLAHCESQCRRWARRGLPVCFRAMRVQLACRSGDSLEAVARAARYAALRTLAVEQGVALVLLAHHQRDQAETLLLQALRGAGVAGLAGMPRSIERDGITWARPWLARPREAIEAYVRRYRLSYIDDDSNDDPRFARNRLRLQVWPALQAAFPQAEGTLADAARWAQQAAACVADLAALDLAACAATNDVLPLTAWRQLAPHRAVHALRRWLQQAGVTAPTAADLERLMAELPAGAPARWPLKGGELRRYRGELRF...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q7NAI9
MSTTNKKQYLIGVSGGPDSIYLLDRYQDQIKVACHINYNKRPTALRDQLIVSDYCLKNKIPLEILSVSPSYQYHKNFQDQARKIRYDFFLSTGLKYQVDQCLIAHHKDDFLETAIMQYDKNQELLFYGLHQESSYQSLKIFRPLLNLWKDEILSYLEQDKIVYGVDESNFLSTYQRNKIRTNLSKLSQEQKQARLDFFLELNKKNQVRYQSVKDFFSSWDCNYLDLINSLEYYNLLYLWFSKNNIKYSKQKAENILSFLQKKNNKRFRLKAGVYLIKEGIKLKIVKL
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
Q9C0N3
MFGLGRPQPTSAEKIAAVENELKVVAEMHSRMVKICTLKCIDKSYREGDLSKGESVCLDRCAAKFFETHQKISDQLQKETQARGGGGFGM
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membran...
Q9UTE9
MSMFGIGKNNQTINPQNIAMAEQEVEMMSDIFNRLVMTCHKKCISPKYYEADLTKGESVCIDRCVSKYFEANQSLSQHMQKRGQENPTP
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membran...
Q6C6U1
MSFLGLGGQNPNGPSNPQKLLAAEAELDMVTDMFNRLVESCHEKCIKADYSSGDLNANEGLCLDRCVAKYFDVNTKVGEVSMRGADGNYGLEDTANTVHAEAWKQRILHGPTLNVKYVHRIKVHEIVRLTMVYLAPWHFN
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membran...
P87108
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membran...
P32830
MSFFLNSLRGNQEVSQEKLDVAGVQFDAMCSTFNNILSTCLEKCIPHEGFGEPDLTKGEQCCIDRCVAKMHYSNRLIGGFVQTRGFGPENQLRHYSRFVAKEIADDSKK
Function: Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. In the TIM22 complex, it acts as a ...
Q9XH48
MDSYSSPPMGGSGSSVSPEVMMESVKTQLAQAYAEELIETLRTKCFDKCVTKPGSSLGGSESSCISRCVERYMEATAIISRSLFTQR
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer me...
Q75F72
MALSSIFGGGSPSQQSNLPTSSASSSVKDQLKGQIAQELAVANATELVNKVTENCFEKCLMAPYTSKQDTCVDQCLAKYMRSWNAISQAYVARIQQASANGDI
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer me...
Q4X0V2
MAIWGSSSSNTASSGEADIKTHLMNQVRQEAAVTNARNLIGKVNEHCFEACIPNPGTSLSSAEHTCLSQCMEKYISFWNAVSRGYIARLANERKAYGGGALDASFVQSGESSL
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer me...
Q9Y193
MEQILDVESLKKLTPEQQKTLISGVKQQAAILTAQNMITDXSERCLTKCITXPGSALSXTERQCLQRCMDRFMETYXLASQXLQNRVXEEIAAXTRMT
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer me...
O45319
MDQLLDVETLKKLSPEQQEQVISGVKQQAALANAQNLVTDISEKCTNKCITAPGSSLASGEKQCLQRCMDRFMESWNLVSQTLQKRLQEEMASSGGMGGGFGQGPSFS
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer me...
Q5AF54
MAFWNSSSSSSSSGQTDSSSTSSPASLRSQQIKQDLQNQISQELAAANATELVRTITENCFDKCILIPKDTLSPTELQCISQCREKYMRSWNVISKAYIGRIQQEQHH
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer me...
P0CS01
MSSFFGSGAGSPSNDMTARKEQMKQSIQQELAIANAQQLINKINENCFAKCVTKPSTSLSSSQESCLSQCMTLYMAAFDQVSRSYVARISKERGVAPGL
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer me...
Q9XGX8
MDKNMLGDLDNLPEEDKLKMASMIEQLQIRDSLRMYNNLVERCFTDCVDSFRRKTLDKQEETCVKRCAEKFLKHSMRVGLRFAELNQGAATTD
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer ...
Q9WV98
MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEEVTCSEHCLQKYLKMTQRISVRFQEYHIQQNEALAAKAGLLGQPR
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer ...
Q8J1Z1
MDGLTAAESRELDQRLQKRQVKEFMSVFGNLVDNCFTACVDDFTSKALSGRESGCISRCVLKSMSTQTRLGERFGELNAAMTAEMQRR
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membran...
Q9P7K0
MDRLNVKEQEHLTQVLEAKQLKEYLNMYSTLTQNCFSDCVQDFTSSKLSNKESECIAKCADKFLKHSERVGQRFAEFNAKYMGQ
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membran...
O74700
MDALNSKEQQEFQKVVEQKQMKDFMRLYSNLVERCFTDCVNDFTTSKLTNKEQTCIMKCSEKFLKHSERVGQRFQEQNAALGQGLGR
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membran...
Q8R183
MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPDTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES
Function: Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin . Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes . Plays a...
Q96H15
MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQLLMIIA...
Function: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cel...
Q6U7R4
MSKGLLLLWLVTELWWLYLTPAASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRTDGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFNDVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLPTTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNHSQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKSHQINSRQTILIIACCVGFVLMVLLFLAFLLRGKVTGANCLQRHKRPDNT...
Function: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation . Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-ce...
P81546
MAPFAPLASCILLLLWVTAPSRACTCAPPHPQTALCNSQIVIRAKFVGTAEVNQTDLNRRYEIKMTKMFKGFSALGNASDIRFVDTPALESVCGYLHRSQNRSEEFLVAGNLRDGHLQINTCSFVAPWSSLSTAQRRGFTKTYAAGCEGCTVFTCSSIPCKLQSDTHCLWTDHFLTGSDKGFQSRHLACLPREPGICTWQSLRPRMA
Function: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP1...
P01033
MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
Function: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP1...
P12032
MMAPFASLASGILLLLSLIASSKACSCAPPHPQTAFCNSDLVIRAKFMGSPEINETTLYQRYKIKMTKMLKGFKAVGNAADIRYAYTPVMESLCGYAHKSQNRSEEFLITGRLRNGNLHISACSFLVPWRTLSPAQQRAFSKTYSAGCGVCTVFPCLSIPCKLESDTHCLWTDQVLVGSEDYQSRHFACLPRNPGLCTWRSLGAR
Function: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP1...
P97273
RRNRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCPA
Function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis (By similarity). PTM: Phosp...
Q9DCD5
MSSAAPAKKPYRKAPPEHRELRLEIPVSRLEQEESLTDAERMKLLQQENEELRKRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHALASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDARNTINKLEELNERYRLDCNLAVQLLKCNKSHFRNHKLADLPCELQDMVRKHLRSGQEVASPSPSPSSSLSPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSGGDPASPPAPGSPNGECCSVSTAGGSPEEELPLPAFDKLSPYPTPSPPHPL...
Function: Plays a role in regulating the structure of the Golgi apparatus. Location Topology: Peripheral membrane protein Sequence Mass (Da): 60520 Sequence Length: 549 Subcellular Location: Golgi apparatus
Q7L0Y3
MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKIPAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEMWRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQFGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTTFRHDKVYVIGSFVDKSMQPG...
Function: Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation . Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends . Together with HSD17B10/MRPP2, forms a subcomplex of the mitochon...
A4IHS0
MAFVNTLLRTIRCSAVHTLVQEGRSLSLLKASHQLTQSRKIMLSNHVRKEEAKSEPNETLDLEEWKSILKSDIGNAEMVKTETQEDSSLNEMQELVEMWRLAGRAVPQSITTEQLQVLMELPTKTARKKYLKYLSVREVMKTNRKEKKKELKESKSKIESLDQLETKEDTPEKKNTFLLHVWDKSIDTMQRWKCVQAMKFGQPLVFDMVYEKNMSRYELENTVCQLMESEGWNRRSTDPFHIYFCSLQPYSMYHKELVKRYIGAWDNVFVTATDKSHVEMFPKEQLVYLTADSPNELKHFDHTKIYIIGSLVDRCQQTGL...
Function: Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, which cleaves tRNA molecules in their 5'-ends. Together with hsd17b10/mrpp2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays func...
Q12893
MQRALPGARQHLGAILASASVVVKALCAAVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLTTVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLTYMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVMPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHSLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSIWPSMDDDEEESGAKVDS...
Function: May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38197 Sequence Length: 351 Subcellular Location: Golgi apparatus
Q9WUH1
MQRALPGARQHLGAILASASVVVKALCAVVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGALAYLLTYMASFNLVYLFTIRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSAWPSMDDDEEEAGAKTDS...
Function: May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38099 Sequence Length: 350 Subcellular Location: Golgi apparatus
Q12239
MQYSSRFLELNIPDSFLNINKIPDATKFITVTYICLTATLFCIRRSLYNKLVLEDPNLDYNLITSPLLQMVPSQIWRYPTSLVLSNFIDTKAWKVVVNLLNLIIGGSFIERNWNSSKEMFKFIIVLGSLTNVLIIMLTLLVSFFSNKVRLDIPLDGNYTILIGFPIIYRQLLPETTIIHLKTPQFLAKNFRFKLLPIFVMFTMTVTQIIWFHHFAQLFSIWVTFFASWSYLRFFQKLAPLNCPSLPTTNSQGGQEILVGDASDTFQLIYFFPDLIKPILRPIFNFIYNVVVVKFKVIKPFHDIDIDIGNTIAESRGAKKI...
Function: May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 39742 Sequence Length: 342 Subcellular Location: Golgi apparatus membrane
Q7ZVW1
MSSQSLHDCLRGRCLGVLRRMEIIGRFRYYFQHPWSRLLVSYLVTFFNFLIFAEDPVSHSQKEAHMSVVGNCFSFIISKYPAGFWSVLKVLLWVLAIICGLIAGKFIFHRRLFGRVLRLKMFREDHGSWMTMFFSTILSLFIFSHIYNLLLLMSVRMRPYMVTEYMGIRNESFMKMAAVGTWMGDFVTAWMVTDMMLQDTHYPDWGRTARHLWRQGHNRIVLFWTVLICLTSVVVLVISTDWIRWDNLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDLDMNLPGLSTTQLKIRLPVCKRIFKEEYHIHIT...
Function: May be involved in endoplasmic reticulum (ER) stress-induced cell death pathway. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 47573 Sequence Length: 401 Subcellular Location: Cell membrane
Q9H0C3
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQRLFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYGIIFLVLILDLNMWK...
Function: Involved in endoplasmic reticulum (ER) stress-induced cell death pathway. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60185 Sequence Length: 514 Subcellular Location: Cell membrane
Q4V9L6
MVSAAAPSLLILLLLLLGSVPATDARSVPLKATFLEDVAGSGEAEGSSASSPSLPPPWTPALSPTSMGPQPITLGGPSPPTNFLDGIVDFFRQYVMLIAVVGSLAFLLMFIVCAAVITRQKQKASAYYPSSFPKKKYVDQSDRAGGPRAFSEVPDRAPDSRPEEALDSSRQLQADILAATQNLKSPTRAALGGGDGARMVEGRGAEEEEKGSQEGDQEVQGHGVPVETPEAQEEPCSGVLEGAVVAGEGQGELEGSLLLAQEAQGPVGPPESPCACSSVHPSV
Function: Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts . May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates ...