ids
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11.1k
Q67X45
MAMAGADGPTAGAAAAVRWRGGESLLLLLLRWPSSAELVAAWGAARASAVAPALAAASAACLALSAMLLADAVLMAAACFARRRPDRRYRATPLGAGAGADDDDDDEEAGRVAYPMVLVQIPMYNEREVYKLSIGAACGLSWPSDRLIVQVLDDSTDPTVKGLVELECKSWGNKGKNVKYEVRNTRKGYKAGALKEGLLRDYVQQCNYVAIFDADFQPEPDFLLRTIPYLVRNPQIGLVQAHWEFVNTSECLMTRIQKMTLHYHFKVEQEGGSSTFAFFGFNGTAGVWRISALEEAGGWKDRTTVEDMDLAVRAGLKGWK...
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Catalytic Activity:...
Q8S7W0
MEGQWGRWRLAAAAAASSSGDQIAAAWAVVRARAVAPVLQFAVWACMAMSVMLVLEVAYMSLVSLVAVKLLRRVPERRYKWEPITTGSGGVGGGDGEDEEAATGGREAAAFPMVLVQIPMYNEKEVYKLSIGAACALTWPPDRIIIQVLDDSTDPAIKDLVELECKDWARKEINIKYEIRDNRKGYKAGALKKGMEHIYTQQCDFVAIFDADFQPESDFLLKTIPFLVHNPKIGLVQTRWEFVNYDVCLMTRIQKMSLDYHFKVEQESGSSMHSFFGFNGTAGVWRVSAINEAGGWKDRTTVEDMDLAVRASLKGWQFLY...
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Catalytic Activity:...
Q6Z2T9
MQGSSTSILHFVPSDPTSTSVLDFLSPTPRGTSPVHDRRLHAGDLALRAGGDRLLVADTVAAVVESLVQAWRQVRMELLVPLLRGAVVACMVMSVIVLAEKVFLGVVSAVVKLLRRRPARLYRCDPVVVEDDDEAGRASFPMVLVQIPMYNEKEVYQLSIGAACRLTWPADRLIVQVLDDSTDAIVKELVRKECERWGKKGINVKYETRKDRAGYKAGNLREGMRRGYVQGCEFVAMLDADFQPPPDFLLKTVPFLVHNPRLALVQTRWEFVNANDCLLTRMQEMSMDYHFKVEQEAGSSLCNFFGYNGTAGVWRRQVID...
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Catalytic Activity:...
Q9ZQN8
MSPLPIFHRLPHATFSSFLLSLSQAGSSKTSVAFLNAFKSEDIIARIGLWWQLIRAVVVVPVFKFLVLLCLVMSVMFFVEVMYMGIVVLYVKLFKRKPEKFYKWEAMEDDVECGSASYPMVLVQIPMYNEKEVCEQSIAAACKISWPSNRIIIQVLDDSTDPASKELVKKECDRWSKEGVNITFEIRDNRNGYKAGALREGMRHSYVKQCDYVAIFDADFQPDPDFLHRTVPFLIHNPKLALVQGRWEFVNAGQCMMTRLQEMSLSYHFTIEQQVGSSTFAFFGFNGTAGVWRISALNESGGWNDQTTVEDMDLAVRATL...
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall . Required for synth...
Q7XIF5
MVEAGEIGGAAVFALAAAAALSAASSLGAVDFRRPLAAVGGGGAFEWDGVVPWLIGVLGGGDEAAAGGVSVGVAAWYEVWVRVRGGVIAPTLQVAVWVCMVMSVMLVVEATFNSAVSLGVKAIGWRPEWRFKWEPLAGADEEKGRGEYPMVMVQIPMYNELEVYKLSIGAACELKWPKDKLIVQVLDDSTDPFIKNLVELECESWASKGVNIKYVTRSSRKGFKAGALKKGMECDYTKQCEYIAIFDADFQPEPNFLLRTVPFLMHNPNVALVQARWAFVNDTTSLLTRVQKMFFDYHFKVEQEAGSATFAFFSFNGTAG...
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Catalytic Activity:...
Q9LZR3
MELGDTTSVIPDSFMGYRDDITMQMSMVLDQIRAPLIVPALRLGVYICLTMSVMLFVERVYMGIVISLVKLFGRKPDKRFKYEPIKDDIELGNSAYPMVLIQIPMFNEREVYQLSIGAACGLSWPSDRIVIQVLDDSTDPTIKDLVEMECSRWASKGVNIKYEIRDNRNGYKAGALKEGMKKSYVKSCDYVAIFDADFQPEADFLWRTVPYLLHNPKLALVQARWKFVNSDECLMTRMQEMSLDYHFTVEQEVGSSTYAFFGFNGTAGIWRISALNEAGGWKDRTTVEDMDLAVRASLKGWKFLYLGSLKVKNELPSTFK...
Function: Possesses glucomannan synthase and mannan synthase activities in vitro. Mannan synthase consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosi...
Q9LR87
MTTFLKSLIFLQDSCLAFLSLMFHRGSSEDAAEALKKLETSINGARISFDTTWTREFRSLFIVPLFKCLVAFCLIISLLVFIEGIYMNLVVLYVKVFERKPEKVYRWEAMQEDIELGHETYPMVLVQIPMYNEKEVLQLSIGAACRLIWPLDRLIVQVLDDSTDQTIKELVNTECAKWESKGVNIKCERRDNRNGYKAGALKEGMKHNYVKLCNYVVIFDADFQPEPDYLQHSVPFLVHNPEVALVQARWRFMNANKCLMTRMQEMSLNYHFMAEQESGSTRHAFFSFNGTAGVWRMAAMEEAGGWHDRTTVEDMDLAVR...
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Catalytic Activity:...
Q6YWK8
MSSSGGGGVAEEVARLWGELPVRVVWAAVAAQWAAAAAAARAAVVVPAVRALVAVSLAMTVMILAEKLFVAAVCLAVRAFRLRPDRRYKWLPIGAAAAAASSEDDEESGLVAAAAAFPMVLVQIPMFNEREVYKLSIGAACSLDWPSDRVVIQVLDDSTDLVVKDLVEKECQKWQGKGVNIKYEVRGNRKGYKAGALKEGLKHDYVKECEYIAMFDADFQPESDFLLRTVPFLVHNSEIALVQTRWKFVNANECLLTRFQEMSLDYHFKYEQEAGSSVYSFFGFNGTAGVWRIAAIDDAGGWKDRTTVEDMDLAVRATLQ...
Function: Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Catalytic Activity:...
Q59288
MKKLFVTCIVFFSILSPALLIAQQTGTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWA...
Cofactor: Binds 1 Ca(2+) ion per subunit. Catalytic Activity: Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. Sequence Mass (Da): 79694 Sequence Length: 700 EC: 4.2.2.5
O80898
MADSSFSLPPLCERISYTNYFLRAVYLTVLGLFFSLLLHRIRHTSEYDNVWLVAFFCESCFFLVCLLITCLKWSPADTKPFPDRLDERVHDLPSVDMFVPTADPVREPPIMVVDTVLSLLAVNYPANKLACYVSDDGCSPLTYFSLKEASKFAKIWVPFCKKYNTRVRAPSRYFLKPISVATEDYEFNRDWEKTKREYEKLRRKVEDATGDSHMLDVEDDFEAFSNTKPNDHSTLVKVVWENKGGVGDEKEIPHIIYISREKRPNYVHNQKCGAMNFLARVSGLMTNAPYILNVDCDMYANDADVVRQAMCILLQESLNM...
Function: Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 85061 Sequence Length: 757 Subcellular Location: Golgi apparatus membrane EC: 2.4.1.-
Q8RX83
MADSSSSLPPLCEKISYKNYFLRVVDLTILGFLFSLLLYRILLMNQNNSVWVVAFLCESFFSFIWLLITSIKWSPASYKSYPERLDERVHDLPSVDMFVTTADPVREPPILVANTLLSLLAVNYPANKLACYVSDDGCSPLTYFSLKEASKFAKIWVPFCKKYNIKVRAPFRYFLNPPAATESSEFSKDWEITKREYEKLSRRVEDATGDSHWLDAEDDFEDFSNTKPNDHSTIVKVVWENKGGVGVENEVPHFVYISREKRPNYLHHYKAGAMNFLVRVSGLMTNAPYMLNVDCDMYANEADVVRQAMCIFLQKSMNSN...
Function: Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 84889 Sequence Length: 755 Subcellular Location: Golgi apparatus membrane EC: 2.4.1.-
P61201
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQN...
Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to ...
Q7V2C8
MSTKTSREIALERRKAMSDGGKKAALHSSSTKDRVRSSQDINSTGATSSNKKVLTSPSKSNIPANKIARKSTSSKLSSKELGIERRKAMSTHGKSAINSSDRTRTDVKSDIKVNKVISTEKPQALKDHNNNIKDNQVVKQNIKRRINQKRKPITNTSRDIVLARREAQSKHGKSASKQNTSAASLARRGDPDLSSREISQRVRELRSKTGSTSKQGNGKCRPCGPNKNGSKLNIADASWKVGKSETDSGQTVTGTQANRSLKTTGNEASTCRTVTGTQYMGAEVTGQFCQDKPKYKQPIRASVTTTTSGNKVTGNEVGRS...
Function: Required for alpha-carboxysome (Cb) assembly, mediates interaction between RuBisCO and the Cb shell. The protein is probably highly flexible (Probable). The C-terminal repeats act as the encapsulation signal to target proteins to the Cb; they are necessary and sufficient to target both CsoS2 and foreign prote...
P45689
MADVTGIALGMIETRGLVPAIEAADAMTKAAEVRLVGRQFVGGGYVTVLVRGETGAVNAAVRAGADACERVGDGLVAAHIIARVHSEVENILPKAPQA
Function: The major shell protein of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered . Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome . The shell probably limits the diffusion of CO(2) into and out of the c...
P45690
MATTHGIALGMIETRGLVPAIEAADAMTKAAEVRLVGRSFVGGGYVTVMVRGETGAVNAAVRAGADACERVGDGLVAAHIIARVHSEVEIILPETPEDSDSAWCIANLNS
Function: One of shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome (By similarity). The shell probably limits the diffusion of CO(2) into and ...
Q31HD1
MSTEYGIALGMIETRGLVPAIEAADAMTKAAEVRLVSREFVGGGYVTVLVRGETGAVNAAVRAGADACERVGDGLVAAHIIARPHKEVEPVLALGNSSPDRS
Function: One of shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome. The shell probably limits the diffusion of CO(2) into and out of the carbo...
D0KZ73
MNNIDLRVYSFIDSLQPQLASYLATSSQGFLPVPGDACLWIEVAPGMAVHRLSDIALKATNVRLGEQVVERAFGSMEIHYRNQSDVLASGEAVLREINHAQEDRLPCRIAWKEIIRAITPDHATLINRQLRKGSMLLPGKSMFILETEPAGYIVQAANEAEKAAHVTLIDVRAFGNFGRLTMMGSEAETEEAMRAAEATIASINARARRAEGF
Function: Part of the carboxysome shell, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) is sequestered. It may control transport of RuBisCO reactants in and out of the carboxysome (By similarity). In an E.coli expression system not absolutely necessary, its presence leads to fewer d...
Q31HC6
MIELRTYVFLDSLQPQLASYMATASMGFLPVPGDSSLWIEVAPGMAVHRLSDIALKASNVRLGQQIVERAYGSMVIHHRDQSDVLEAGQRILDHLQTREYDRQQCVVMWNEIIRGVTADHATLINRDNRKGSMILPGQSMFIMETEPAGYIIYAANEAEKAADVTLVEARAVGAYGRLVMCGKEGDITEAARAANEALKRLTCRS
Function: Part of the carboxysome shell, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) is sequestered. It may control transport of RuBisCO reactants in and out of the carboxysome. Sequence Mass (Da): 22682 Sequence Length: 205 Domain: Contains 2 BMC domains, trimerizes in a stagger...
Q7V2D3
MEPTSSLNRGDRKKGSSLVTGSEVQSQSNGASCFITTDSEKSLVSRQASQVEQIELRTYVFLDSLQPQLAAYMGTVSRGFLPIPGDSCLWMEVSPGMAVHRVTDIALKASNVRLGQMIVERAFGSLALYHKDQSTVLHSGDVVLDAIGSEVRKRTKPSTSWTEVICAITPDHAVLINRQNRSGSMIQSGMSMFILETEPAGYVLKAANEAEKSANITIIDVKAVGAFGRLTLAGKEGDVEEAAAAAIRAIDQISNY
Function: Part of the carboxysome shell, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) is sequestered (Probable) . It may control transport of RuBisCO reactants in and out of the carboxysome (Probable). There are estimated to be 6 CsoS1D hexamers per carboxysome . Sequence Mass (Da...
G5EBM1
MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMSSSTTISTEDFNTIEIESTFEICRSGSYTEEPILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQKEIYAVFQRRIKSELCIETVKKKFQPLLPNAIQTCEFDEETMIRMIYGAGIRIDSVDFWNRFTSKATISLDCYSRLISYSSDSLTLSGTHRSGFTYHWISTPPVTYHRTENKDPNIQEPSPVEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSLEEYDSQSRMPRTDAKKSNHKHKYCYEMNSNPRGTVLILSNENFKNMERRVGTKQDEVNLT...
Function: Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms . Also cleaves, in vitro, inactive caspase csp-2 isoform b . Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 can...
P23093
MKKCTILVVASLLLVNSLLPGYGQNKSIQAQRNLNELCYNEGNDNKLYHVLNSKNGKIYNRNTVNRLLADAPEGKKNEKKNEKIERNNKLKQPPPPPNPNDPPPPNPNDPPPPNPNDPPPPNPNDPPPPNANDPPPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPPPPNPNDPAPPNANDPPPPNPNDPAPPQGNNNPQPQPRPQPQPQPQPQPQPQPQPQPRPQPQPQPGGNNNNKNNNNDDSYIPSAEKILEFVKQIRDSITEEWSQCNVTCGSGIRVRKRKGSNKKAEDLTLEDIDTEICKMDKCSSI...
Function: Essential sporozoite protein . In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands . In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes . Bin...
P06915
MKKCTILVVASLLLVNSLLPGYGQNKIIQAQRNLNELCYNEGNDNKLYHVLNSKNGKIYNRNTVNRLLPMLRRKKNEKKNEKIERNNKLKQPPPPPNPNDPPPPNPNDPPPPNPNDPPPPNPNDPPPPNANDPPPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPAPPNANDPPPPNPNDPAPPQGNNNPQPQPRPQPQPQPQPQPQPQPQPQPRPQPQPQPGGNNNNKNNNNDDSYIPSAEKILEFVKQIRDSITEEWSQCNVTCGSGIRVRKRKGSNKKAEDLTLEDIDTEICKMDKCSSIF...
Function: Essential sporozoite protein . In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands . In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (By s...
P08672
MKNFNLLVVSSILLVDLFPTNCGHNVHFSRAINLNGVSFNNVDASSLGAAQVRQSASRGRGLGENPKDEEGADKPKKKEEKKVEPKKPRENKLKQPPAGDGAPEGDGAPAAPAGDGAPAAPAGDGAPAAPAGDGAPAAPAGDGAPAAPAGDGAPAAPAGDGAPAAPAGDGAPAAPAGDGAPAAPAGDGAPAGNRAGGQPAAGGNQAGGNRAGGQPAAGGNQAGGNRAGGQPAAGGNQAGGQPAAGGNQAGAQAGGNQAGAQAGGANAGNKKAGEAGGNAGAGQGQNNEAANVPNAKLVKEYLDKIRSTLGVEWSPCSVTC...
Function: Essential sporozoite protein (By similarity). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infec...
Q7K740
MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNEDNEKLRKPKHKKLKQPADGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANSAVKNNNNEEPSDKHIKEYL...
Function: Essential sporozoite protein . In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host he...
P04922
MKNFILLAVSSILLVDLLPTHFEHNVDLSRAINVNGVSFNNVDTSSLGAAQVRQSASRGRGLGEKPKEGADKEKKKEKEKEKEEEPKKPNENKLKQPEQPAAGAGGEQPAAGAGGEQPAAGAGGEQPAAGARGEQPAAGAGGEQPAAGAGGEQPAAGAGGEQPAAGAGGEQPAAGAGGEQPAAGARGEQPAAGAGGEQPAAGAGGEQPAAGARGEQPAAGAGGEQPAPAPRREQPAPGAVAGDGARGGNAGAGKGQGQNNQGANVPNEKVVNDYLHKIRSSVTTEWTPCSVTCGNGVRIRRKGHAGNKKAEDLTMDDLEV...
Function: Essential sporozoite protein (By similarity). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infec...
P13815
MKKLSVLAISSFLIVDFLFPGYHHNSNSTKSRNLSELCYNNVDTKLFNELEVRYSTNQDHFYNYNKTIRLLNENNNEKDGNVTNERKKKPTKAVENKLKQPPGDDDGAGNDAGNDAGNDAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNDAGNAAGNAAGNAAGNAAGNAAGNDAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNDAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNAAGNEKAKNK...
Function: Essential sporozoite protein (By similarity). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infec...
P26694
MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDADNGDADNGDEGIDENRRHRNKEGKEKLKKPKHNKLKQPGNDNVDPNANPNVDPNANPNVDPNANPNVDPNANPNVDPNANPNVNPNANPNVDPNANPNVNPNANPNVNPNANPNVNPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNRNNEANGQGHNKPNDQNRNVNENANANNAGRNNNNEEPSDKHIEEFLKQIQNNLST...
Function: Essential sporozoite protein (By similarity). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infec...
P08677
MKNFILLAVSSILLVDLFPTHCGHNVDLSKAINLNGVNFNNVDASSLGAAHVGQSASRGRGLGENPDDEEGDAKKKKDGKKAEPKNPRENKLKQPGDRADGQPAGDRADGQPAGDRADGQPAGDRAAGQPAGDRADGQPAGDRADGQPAGDRADGQPAGDRADGQPAGDRAAGQPAGDRAAGQPAGDRADGQPAGDRAAGQPAGDRADGQPAGDRAAGQPAGDRADGQPAGDRAAGQPAGDRAAGQPAGDRAAGQPAGDRAAGQPAGNGAGGQAAGGNAGGGQGQNNEGANAPNEKSVKEYLDKVRATVGTEWTPCSVTC...
Function: Essential sporozoite protein (By similarity). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infec...
P50461
MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE
Function: Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (B...
O74369
MSVEKAPELRVLSFNCWGLRFVSKYRTERLKAVGEKLAKCDYDIVLLQEVWSIYDFQEIRNLVSCNLVYSRFFHSAAMGAGLAMFSKFPIIESSMNKYPLNGRPQAFWRGDWYVGKGVATASLQHPSGRIISLFNTHLHAPYGKGADTYLCHRLSQAWYISKLLRAAVQRGHIVIAAGDFNIQPLSVPHEIITSYGLVNDAWLSVYPDQVEHPPNRFSMNDKELVEIAGTTCDSRLNTWRENISSKDMDDFVAKRLDYVFHSPSTCEAKNAKVVFLERVPKLDCSYSDHFAIETVLSIKLQPIPVQETRVSYSIIDDTLG...
Function: Inositol phosphosphingolipids phospholipase essential for the coordination of cell wall formation. Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C). Location Topo...
O85043
MKIMQVEKTLVSTNRIADMGHKPLLVVWEKPGAPRQVAVDAIGCIPGDWVLCVGSSAAREAAGSKSYPSDLTIIGIIDQWNGE
Function: Probably forms vertices in the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) is sequestered. Has been modeled to induce curvature upon insertion into an otherwise flat hexagonal layer of major carboxysome subunits (Probable). A minor shell protein, only 12 pe...
Q9BPE1
MLCLPVFIILLLLASPAAPNPLEKRIQSDLIRAALEDADMKTDEREIVNIIDSISDVAKQICCEITVQCCVLDEE
PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or 'C1-C4, C2-C3', since these disulfide connectivities have been observed for conotoxins with cysteine framework V (for examples, see AC P0DQQ7 and AC P81755). Sequence Mass (Da): 8314 Sequence Length: 75 Domain: The cysteine framework is V (CC-CC). Sub...
Q1A3Q7
MLCLPVFIILLLLASPAAPKSFETKVQSDLTRTDGNMETEENLGEVRKVYCCLGVRDDWCCAGQIQI
PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or 'C1-C4, C2-C3', since these disulfide connectivities have been observed for conotoxins with cysteine framework V (for examples, see AC P0DQQ7 and AC P81755). Sequence Mass (Da): 7448 Sequence Length: 67 Domain: The cysteine framework is V (CC-CC). Sub...
P81755
MRCFPVFIILLLLIASAPCFDARTKTDDDVPLSSLRDNLKRTIRTRLNIRECCEDGWCCTAAPLTGR
Function: Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish. PTM: O-glycan consists of the disaccharide Gal-GalNAc. Sequence Mass (Da): 7587 Sequence Length: 67 Do...
P58848
FCCPFIRYCCW
Function: Causes dorsal fins drooping in fish. No effect is observed when injected into mice. Sequence Mass (Da): 1441 Sequence Length: 11 Domain: The cysteine framework is V (CC-CC). Subcellular Location: Secreted
P0DJL6
ECCHRQLLCCLRFV
Function: Interacts selectively with the G-coupled somatostatin sst3 receptor (SSTR3). It displays antagonist property for SSTR3 (Ki=1.5 uM). Other somatostatin receptors are also affected, but with a lower selectivity: SSTR5 (Ki=80.2 uM), SSTR1 (Ki=169 uM), SSTR2 (KI=159 uM), SSTR4 (Ki>100 uM). PTM: Contains 2 disulfi...
Q9U6Z6
MRCLPVFVILLLLIPSAPCVDAHPKTKDDMPLASFHDNAKGTLQRFWKKRGCCPKQMRCCTLG
Function: In vivo, low levels of the peptide injected into male specimens of the Siamese fighting fish causes an immediate aggressive display in this fish in response to their reflection when placed in a mirrored aquarium; High levels of the peptide suppressed this behavior. No effect is observed when injected into mic...
A0ST41
MVKRIEADNLFELTAELVSASSKLHKFLDQKNLPQPSFDAPAPSVALNSANKPYYDARSAIVEAAEQLIRLVRGPRDTLLALSFEHCATASMQVVFKYKFANHIPLHGSTTYSKIAEAVGDGVTTALVERTIQHCASFGLFETIPGAMLLQCYLVLLVTDPDLEAWMYLSAVIAYPAGAAIPKAVEQYGVSHEADESGYGASIGRKIAQFQRFREPDGKKDHEMFARAMRGIAAGGAYDFRHAVDGGYPWHLLAEGAGHLVVDVGGGPGHVAMALAEKYPSLRFQVQDLPETVQVGAKNCPEHLKSRVSFQSHDFFTSQP...
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin . The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydr...
Q2I0M6
MMQFQRDLEASLEAVSANAQELLKSLKSRKDVQDLNASLPKDPLDNCDAQTQAARAQLAEAATRILQLSIRPQEYLEHLQNGYQHLTCFRWLVELNILDHLPHSGTISYTDLARKASVPPMQLRSICRMAICNGFLEEPEANQVRHSRISALFARDESYLGWARWMVNYSVPAAYKLSDATRSWGETVAKDQTAFNLGMDVKVPFFDHLRQTPAMKDAFAAYMRNVTSNATWGLQHAVTGFDWASLPRGAKVVDVGGSLGHGSIAIAKEHTHLTFVIQDLPETVAGARKEMAQNDKIEASVKSRITFQEHDFFGPQTVKD...
Function: Dual O-methyltransferase/FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin . The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces activ...
A0ST42
MAPPITDDDLDGLKQPYVTFSSGSASPPRSTAEAMDFEEQILEAIKSDAFLVDWIGEDDKGNPQNLPYWRKWVITMSLALYALSTTFSSSVFGAATHVLAEEFALPAETVVLGCTSLFMVGFATGPIFWGPFSEAFGRTRPLLAGYLGFAVLQLPIADARSLTSICILRFLGGFFGAAPSSILSGILADIWSPRERGFAMPTVGAFLTIGPILGPLIGSVLVQSVLGWRWIANVVAIASFLIALSTFPFLPETYTPLLLARRAERMRHMTRNWAYRSKSEEAQSSIGDFAERYLLRPARMLALEPILLMMTLYVSVSFGL...
Function: MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin . The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl...
A0ST43
MGSYFSLKNSDLHPSCIALPRSAEEVSKAVRTLSLGAHKWEGQCQFGVRGGGHTPFKGAASTDNGIVLDLLHMPSAGISPDYETITVSPSTTWDLVYEVLDAHNRSTLGTKVAGIGVGGASTSCGVSYFSPRYGYICDMVENWEVVLATGDIVNANANENADLWKALRGGINNFGIVTAVTLKAFEQGPFWGGQTFHSIETRQEHFKNHAKLASAHPYDPYAHYINTLVLANGGHWFIGNSIQYTKSDPPVAEPEVFKPFLKTERTPIFPGLPEDTLRVDNVTSFSREYAANTLYPQRWQFACISFAPDADFMETFFQMA...
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin . The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as ...
A0ST44
MADSLVLLTGATGFIGFRILVELLRQGYSVRAVIRSAAKGQWLESRLTAVMKGSDYKDRFQTTIVADFVTDGAFDQAAENTSYIIHVASPIVSSDNPDDWEHDFKRVAVKGSIGVLEAAKRSGTVRRVVITSSMVGLFSPKALFAEPSEVPLNAESRIPEMEPPYAHKMLAYQAGKIASINSAEAWIKHEKPAFDLIHMHPSFVTGRDDLATTREDLRKFSSNWHSMQIVLGHKNPIGKPILTCHNDDVARCHVSALDPKVAGNQSFLISCSPEDGSEWDNVKKIVQREFPEAVAQGVLPNDGHMPTVNKGVRFDVRKTE...
Function: Ketoreductase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin . The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl r...
A0ST45
MASSNRRVLVNGGGPAGAVTAFWLAKGGFEVVVTERSMSRPYGQGVDVMGRAVDIIKKMGLEQRIRDSTTGEAGLTVVDDQGEDVAPPLGTAPIEGGTASVTQEIEIMRRDLTKIFVDAAEALPNVTFRYGCTVDEVQQHEKSITAVLSDTGDPEDFTAIIGADGLGSAIRKLTFDPEINRRSVSPTNTYVAFFSIPGDPKYVSSAARRLSPAPSLCPRSELCDSEGGHDANAYDTPVGKLQHANKGRGILVRPIDKKGTQRSCYLMSQSDSQELAQVARTGSQEDQKALLDNRFREFTGPLGKRAVEGMHSADDFYFTR...
Function: Monooxygenase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin . The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl r...
A0A2G5I8W0
MTSTITTTETLQDAVPFVAPPSPPEDTSNKELPEKPYYDVEFNYRLDPRDGGDEVIWGGTVGLMRRKYETRTVRINNERGNEHNFNLDTHGFAWVKHKTSVTEFADYLAIRQGPYFGEVAEMLKRVTGATKVHVIGHLHRSLNYNDTTEEEKNAPDMTMTKGQTPGRFVHVDQSYQGAVRRLYLDLPQEEARRLEKTRWAIINVWRPVRKVTNEPLAVCDARSVREDELFNTLHLVPMRWPDAAPQENQMWAVAPPKTPTQHKWHYVSGMTEDEALLIKMFDSKKDGTARRVPHSSFPTPDDFGEPRASTETRCFVFWED...
Function: Hydroxylase/desaturase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin . The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the h...
Q8WYA6
MDVGELLSYQPNRGTKRPRDDEEEEQKMRRKQTGTRERGRYREEEMTVVEEADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSC...
Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-s...
Q6IP59
MEDDGKSPPDSAYGEPKKYDPNFKGPIQNRGCTDILCCILIVLGIIAYVAVGIVAWTYGDPRKVIYPTDSKGQFCGQVGTPNEKKPFLFYFNIMKCASPLVLLQFQCPTTQICVENCPDRFLTYLSVATTQQNFDYYKQFCRDGFNNFTKSPVEVLRDRDCPAMITPSKPFTRRCFPAINTQKGVVMVGNSTTFDDGRGDKQRNVTDLLEGAKKANVVLEARQVAMKIFEDYTVSWYWIIIGLIIAMVISLIFVVLLRFLAGIMVWVMIVLVIAVMGYGIFHCYMEYARLKGQSGSDVTLKDIGFQTDIRVYLHLRQTWL...
Function: Choline/H+ antiporter, mainly in mitochodria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway. Catalytic Activity: choline(o...
Q7T2B0
MGKKKQEEEQNSSEYGAPAQYDPTFNGPIHKRSCTDIICCVLFMLVITGYMVVGILAWLYGDPRHVLYPRNSTGMFCGIGQNQNKPSVLYFDILKCATATNIMAAALQGLQCPTTQVCVSSCPSGFWALSPLAYLPNAKPADYFQQELCVPSLQLKDTTYTVMEIINKELCPYYYTPTTSVLDRCLPSLGGSAYNPSNIPANFSLPGLSINQTLSTIANATSDLTNSFNMKDVGLRIFEDFAKTWQWIVAGLVIAMVVSVLFLLLLRFTAPVLIWILIFGVLAVGAFGIWYCYNDYMSLASSNLTFSNVGFTTNVQVYLQ...
Function: Choline transporter that seems to play a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury. Also described as a t...
Q53GD3
MGGKQRDEDDEAYGKPVKYDPSFRGPIKNRSCTDVICCVLFLLFILGYIVVGIVAWLYGDPRQVLYPRNSTGAYCGMGENKDKPYLLYFNIFSCILSSNIISVAENGLQCPTPQVCVSSCPEDPWTVGKNEFSQTVGEVFYTKNRNFCLPGVPWNMTVITSLQQELCPSFLLPSAPALGRCFPWTNVTPPALPGITNDTTIQQGISGLIDSLNARDISVKIFEDFAQSWYWILVALGVALVLSLLFILLLRLVAGPLVLVLILGVLGVLAYGIYYCWEEYRVLRDKGASISQLGFTTNLSAYQSVQETWLAALIVLAVLE...
Function: Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) . Also describ...
A5PMW0
EPRKFDPTFRGPVYNRGCTDVLCCVLFVIVILGYIALGTVAWIHGDPRKVIYPTDSTGQFCGQKGTPNAKKAILFYFNILKCASPAVLINLQCPTTQMCVSKCPDRFATYTDMQLLYRFNKSHWDYYKQFCKPGFNNPQKSVAQVLRDEDCPSMIVPSRPFLQRCFPDFITRNGTLTVANKTAFKDALDTARSVTELRDAANGITSIHEAKEVGMKIVEDYASCWYWIVIGLFIALVISLIFILLLRFTAGFLLWFIIFAVILLVAYGIWHCYWEFAVLRETPGADVTISDIGFQTDLHVYLQLSQTWLVFMVTLGLTEA...
Function: Choline/H+ antiporter. Catalytic Activity: choline(out) + n H(+)(in) = choline(in) + n H(+)(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 79471 Sequence Length: 702 Subcellular Location: Cell membrane
B0S5A7
GCTDVLCCVIFVIVILGYIVLGTVAWMHGDPRKVVYPTDSYGQFCGQQETPNANKAILFYFNILQCANPSVLINLQCPTTQLCVSKCPDRFATYIDMQYSYRRNKGSWEYYKQFCKPGFNNPDKPISQVLRDEDCPSMIVPSRPFLQRCFPDFITRNGTLTVANQTSFKDGHGKIRSVVDLRDAANGITSLLDAKEVGTKIFEDYASSWFWILIGLVISMLVSLVFILLLRFTAGVLFWLVIFGVIAAVGYGIWHCYWEYSSLKGKPDSDVTISDIGFQTDFRVYLQLSQTWLIFMTSLAVIEAIIILVLIFLRNRVRIA...
Function: Choline/H+ antiporter. Catalytic Activity: choline(out) + n H(+)(in) = choline(in) + n H(+)(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 79503 Sequence Length: 700 Subcellular Location: Cell membrane
Q8NCS7
MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFE...
Function: Choline/H+ antiporter. Catalytic Activity: choline(out) + n H(+)(in) = choline(in) + n H(+)(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 81694 Sequence Length: 719 Subcellular Location: Cell membrane
Q5RJI2
MARKRKPPSSQGDPRRYDPDFQGPTAKRTCTDVLCCLIFLLFILGYVLLGLLAWAHGDPRKMAYPTDSQGHFCGQKGTPNENKTVLFYFNIFRCTSPSMMLRLQCSTTQICVSRCPERFLTYLDMQFLNKEDKNYWEYYRQFCKAKAKPVETLRDLLISGDCPLAVYPSRPFLQRCIPDLSALNGTWTPGSRMKFEDGSGQTRTMLEFREAANGISDLINARTIGLKLLEDYATSWKWILIGLTVAMALSWTFLILLRFTAGFLFWFFIFGVLGIIGYGIWYCFLEYSSIQQRPQSTFWMYGFGIQRRVNMFFHLKETWF...
Function: Choline/H+ antiporter. Catalytic Activity: choline(out) + n H(+)(in) = choline(in) + n H(+)(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 81429 Sequence Length: 710 Subcellular Location: Cell membrane
Q06686
MNMGGSSSTAAKKATCKISMLWNWYTIDTCFIARSWRNDTKGKFAGSCIGCFALVVVAQWLTRFSRQFDVELLKRQKIKHLASYSPEEYVVKCGEEDAKSDIEELQGFYNEPSWKTTLISLQKSFIYSFYVWGPRRLNEPEDDLLKKVLSCCTLITPVDLYPTFLDHMIRVTIFVLQWGLSYIIMLLFMYYNGYIIISCLIGAIVGRFIFCYEPLGSLGANGSAQGTVSYDKESDDRKCCL
Function: Required for high affinity copper (probably reduced Cu I) transport into the cell. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 27534 Sequence Length: 241 Subcellular Location: Cytoplasmic vesicle membrane
J9VLN4
MDMGNMGMGMGMGMDSGHNHSHMNMGSGHGADSGHACRISMLLNFNTVDACFLSPNWHIRSKGMFAGSIIGIFFLCVLIELIRRLGREFDRWLVKRAGVNSTCGELSSVAEYGKDGAQGGAVVRVAPRFRYVPSWPHQILRGFIYGSQFTAAFFVMLLGMYFNVIVLIFIFLGQTVGYMLFGRDTCGGGFDFGAQGRCC
Function: Required for high affinity copper (probably reduced Cu I) transport into the cell (By similarity). Plays a role in fungal pathogenesis during host infection . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 21810 Sequence Length: 199 Subcellular Location: Membrane
O43246
MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLVILFIVILGFILAQPHNWSADEGGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFI...
Function: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 68268 Sequence Length: 635 Subcellular Location: Membrane
Q8BLQ7
MARGLPSTACLARFCQKLNRLKPLEESSMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGTVAKDMAGPAVLLSFLVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGEIWAFLIGWNVLLEYLIGGAAVARAWSGYLDAIFNHSIRNFTESHLGVWQVPFLAHYPDFLAAGILLVASAFVSCGARVSSWLNHTFSAISLIVILFIIVLGFILARPHNWSAEEGGFAPFGFSGILAGTATCFYAFVGFDVIAASSEEAKNPRWAVPMAIAISLSLAAGAYILVSTVLTLMVPWHSLDPDSALADAFYRRGYSWAGFI...
Function: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 68350 Sequence Length: 635 Subcellular Location: Membrane
O94722
MSFFSAAKQSLGNSLIKLGTSMAQNSQGPVDDSSLSQLENLLPPLQILTARAAMAAMNMSNDTSMSGMNMTNSTTPMSGMNMTNSTTSMSGMNMSNSTTSMSGMNMTNTTTTAKASSCKLSMYWNWYTIDACFITKHWHITSKHMFVGSIFGIIFMMMALELVRRGQREFDRWCVRRFSPASNSCCHSGAPVHSGPSMALRIFLHFLRSCFYLVQYIVAYIAMLLAMYYNGYVILFLFCGTFFGYFLFGADTISTKASSSVQTKTIVQVADEKHEHDSSQYSDTTPTTE
Function: Required for high affinity copper (probably reduced Cu I) transport into the cell. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32020 Sequence Length: 289 Subcellular Location: Membrane
Q9P7F9
MSLSKMSMSGMSGMGMGSSSNSSAATCRMSMLWNWYIHDSCFLAKSWHINTGNKFAGSIIGIFFFAVAIEGLSLVQRMFDRWIVAHSNGKTLSGPLRIFFPSSTVHVTVWQQLIRAAMYSSFYLSATILMLIVMSFNGYAILFGFVGAWIGFFLFASDTYGTPSTGTGCCESR
Function: Required for high affinity copper (probably reduced Cu I) transport into the cell. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 19012 Sequence Length: 173 Subcellular Location: Membrane
Q9USV7
MNHGGNSTMRHCSMKMTFNTDYDNLCIVFKSWHIGNLSQFLLSLLAIAILGYLFERLRSFTSLKETEFQRGYAGQQSEGLLTHHSKSLKSGRPFRLCALYAVQLVFSYFLMLVAMTYNAYVILAIAIGAAFGYRRSHCDTVQTVGLCH
Function: Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 16747 Sequence Length: 148 Subcellular Location: Vacuole membrane
Q4WCY0
MNMDHSSHSTMSSSSSMTMTMVFTNSHDTPLFSSAWTPSSSGAYAGTCIFLVVLAIINRCLVAFKASMEHYWFATHLNRRYIAIAGKSSEAGRIDTDPDAKVASLVTAQGVEESVKVVRRVSREPIPWRFSVDLPRAAIFLCITGVSYLLMLAVMTMNVGYFCSVLAGAFLGELAVGRYIQWNEHDH
Function: High-affinity copper transporter of plasma membrane that mediates copper uptake under low copper conditions . The mechanism driving the transmembrane transport of copper has still to be determined (Probable). Acts as a potential virulence factor . Catalytic Activity: Cu(2+)(in) = Cu(2+)(out) Location Topology...
Q32NV1
MCEEGETYCPEVKDAKQAKSLGKICMKCKESSAALLIRAGDAFCKSCFKEYFVHKFRATLGKNRVIYPGEKVLLAYSGGPSSSAMVRQVQEGLSRDAPKKLRFVPGILFIDEGTACGMSWEERQQILSEICSVLQQTKIPFHIVSLEQVFSLPGSVLQRGAPEQRPNYKEEVDRFLVQEREQGDAGCSEMLERLEVTDSDSPGSSDKMYQSTCSRPPDMHTQKLKQLFASAKTLTAKQQLLHTLRSHLILHIARTCGYSKVMTGESCTRLSIRLLSNVSLGRGAFLPLDTGFCDSRYGDVDIIRPMREYSSKEIAYYNRF...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Sequence Mass (Da): 57315 Sequence Length: 512 Path...
A6QYX4
MTLDSRYGGEVYGGSKVVKRMEKYRPQNAPKNRQRKLLLPLSYGISSSTLLHILNLQLERQISSGLGRRAYDIHVLNIGTCEQSDSHRLGLFREAYPLHTYTQVPLHSIFKHDTTIKDVISEYGGPEFADDPSKTDQERLDIFRLSLSTATARADIDGILLTRLVVAIAKEQDCDGILWGDSDTRLASKALSNVAKGRGFSVPWDVCDGMSPWGIQFNFPMRDLFKFELSTYASLALPKSLNVVDSERPSVDNLSNKNMSIEDLLAHYVETQGQKYPGVMANIVRTINKLQPQSADTDHKCMLCGMPVDYSGEDPAIIGG...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is...
A0NEF7
MCSIVEDDFGDEGGAHAMKEDTPQPELGGNELCRKCNTEQAVLKLNQKEPQCRVCFLNYVRHKFRASLGSTKIVRRGSRVLIILTGEPANVTLLDMVRFGLEQDAFKQLRIVPVLLYVDDDFVGNTSEARLQQLAERLQVFKQFESFPAYYTVCGSSRHVALTFDGAFSPAGFEQDEARLLQVLDAVRSVSSKQDLLEQVRKQTYRQIGHALQCAYVFLSDIGVDLAKTLLSNVALGRGCSLAQDVAFCDDRYNTVKLVRPIRDLNPDEVSNYLQYSEQPLLSYSPAKHFEDKPSLQNLTAKFIDNLMQSFPSTVSTVYR...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Sequence Mass (Da): 46861 Sequence Length: 417 Pathwa...
O65628
MACNSSGCESGCYDREKDNGSKIVDDAVSGGGNHESVCVKCKCNAPMTFGDGGFDDGRFCADCFRNNVFGKFRLAVTSHAMITPSDNVLVAFSGGSSSRVSLQFVHELQIKALKNYEASRDRSLPVFGVGVAFVDETAAFPALSTEMIDAIEWVRYTVSCLSPPAKDLHVVPVESIFGSDSLDARDRLLKLLDSVPDDTGKEDLLLHLKMLSLQKVAAENGYNRLVLGSCTSRIASHVLTATVKGRGYSLSADIQHVDARWKVPIVLPLRDCVRLEITRLCLLDGLKTVELACRSQCGINDLVSSFVALLQEENPSRECT...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Sequence Mass (Da): 50399 Sequence Length: 458 Pathwa...
Q75BK0
MKCKRCTTSEGCLVSRNETFCGECFSRFVLLKFRKQMMMDEYCQQVFKVLYADKHRTAVEADEQNKRSVVLVPLSLGSSSLAMLDLLNQTLSEQRAAHNRTGFQVKVVLCGFSADMDELKRLAESLQTERLAMNSDCIKLYLLDLDRSFSTCEIHKLLLANDNHGSRKIATRENATLSSILDQFSRRSSRDDMLWFARQHLIKKFASQHQVKVIMWGHSVTRLADEVMSLVIKGRGAQIAATLDSTGMDVEYGALFKNLYPLRDVLLSEIDAYCSLSKLQRYIYNYSLQGSLFIKSQDEAAQANRAVPMAKNMTINELTR...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is...
A1CBI6
MPGKELTDPCVDCADAEAILTVRCRRLCQDCYARFVNFKVFKRMENYRLRRNMSRTGPCKLLLPLSYGTSSSVLLHILNAQIQHERAKSHPSPGFELHVLVIEPSTVSTSSPPHDEGFDLLQQTFPSHSFTRVSLHNVFELDPSIQDVLSQFSSEGFTDDATMSDKDRLDAFRASITTATSRVDVDYILITRLVVAFAKKIECRGVVWGDSDTRLAAKTLANVAKGRGSAITWQVCDGMSPFGLEFSFPLRDLYKAEVQNYASFFPELAKIIIPDEPPSENILTKNLSIDELMMRYVQTQGEKYPGIMANVTRTASKLQA...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is...
Q3SZG9
MCEMSEEYRESAPKGPPPPRLGTGDQKCVKCKEGLPVVVIRAGDAFCRDCFKALYVHKFRAMLGKSRLIFPGEKVLLAWSGGPSSSSMVWQVLEGLSRDSAKRLRFVPGVVYIDEGAACGQSPEDRARTLAEVKLALQTTGFPWHAVALEEVFSLPPSALRCSAQEAAGTEGAYKAAVDSFLQQQHALGTNGVERQSQHCAQDPQSPTGPPTTAQTQALSRLFDSVKTLTAKEELLQTLRTHLILHVARNHGYSKVMTGDSCTRLAIKLMTSLALGRGAFLAWDTGFSDERHGDVVVVRPMREHTLKEVAFYNRLFAVPS...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Sequence Mass (Da): 54353 Sequence Length: 501 Path...
Q19906
MELGNFVTDLNGKKCVKCDKDAKFTGVDPKKAWYCQECFVQMVRNKFRSSLSKKKIYKDADARDTLIVFDGTLSGTFLLHQINDALKQITYKRLMVKPTVLVLVSLTEDTEIQMVIKRIQEIKKSVLENVRWVVAHLACSMYDEDFKLKENECNGVEKISDYNQLIASCSVPTYRKELERVLKEKCLQKIACSMGILKCMVPDHADDLGRLAIDQLCLGRGGSISTLVTVTDKRPDFMLIRPLCDISKKELAVYNYLCDIDKHCIHIAQQNNQQKSVQTLTDAFICTLENEKFYSTINTVLSTAAKIHNTSIGKDDSKCS...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position. Sequence Mass (Da): 39412 Sequence Length: 349 Pat...
Q59ZY9
MPEAIVYLTETEICQKCKTENAVVHARVEKLCSNCYIRFIRGKLRKQMHDERYKVKFGRAVEQYGTQRILLALSGGESSLVLLDIFGSLLQEQNELHKGKQGFELVVVNLDEYELDSLNNRIQKVFPELLAKYQPVKISLNVLSLDSYVDEESLHRILLTPDFRAMSKSIDPTRVTLTEILRLCPNKSSAEDLLTIVYNDLILRVAAKEDCQTVVYGHCMTRLANEIIALTVKGRGSIIHKSIADHTETIDDKEIKVMFPLREILQAEISAYVKLAELNKYVISSTVQKSKINKNLTIRDLTTNYFKQLDATGYASTAST...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is...
Q6FLE5
MTAEQCQRCNKNAVEVISRKELFCAECFRVFVMQKQRKQMMSDDYYRDIFKVMYKDKIRSAEEAEQQNKNSTILIPLSFGSSSLMMLDIVHLTLLEQKMQHQKTGFNVDVLICYRESNDELLTNIQSNIKELSTVRYSENKDNIRFHTLCLDSMFEIDKELIDQVVLHNVEFTGRQVSINESEHANLSLQTVLTSCPNRSTKEDIIDFVTKHLVKKYAYQNGQKAILWGHSMTRLADEIISCVVKGRGAQISSKLNTTNLDVNYGSRFKNLYPLKDILLTEVDAYCALFDLSKYLIKYELQDSLLVNKLKKEKHIGNQRL...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is...
Q1DK31
MSCVDCRFAPACVTVRTRNLCENCFIRFLQTKVLRRMERYRLRNAPKDRQRKLILPLSYGVSSLALLHIVSSLLLKQRTTGQKRTAFDLHVLIVDPVSLHPSKGAAASGRLAKIKEAYPDNTYSEVPLRSIFDYDPDIRGDISQHTGIPLGSNPSRSDEEILNLFRASFSTATARADIDGILLRRLIVAFAKSHKCDGILWGDSDSRLAAKTLANVAKGRGSSLVWNVCEGMSPWDIYFNFPLRDLYKSELEVYASYALRDLQQIIDQDPRNFEDLSNRHMSIEDLMSQYVLTQGAKYPGVMANIVRTVDKLTTPGVENA...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is...
Q6DC53
MCQVEEDYNGLECNQEKIPVSGLNRKCMKCKEGTAVLIIRVSDAFCRSCFKEYFIHKFRAMLGKNRVIFPQEKVLLAVSGGAASCTMLSQVQEGLSRDAPKKLRFMPGIVYIDDGGACGRSEDERQTSISQLKNIFTQTGFPYFIVPLEKVFSLPTSVLVPGTSDPDPSNPCYKQAVDKYLKEKQKLREEEAVCAVAQLNLEDSAYLPEHKLALQRLFSSLKTLSAKQEMLQTLRQHLILHVARENSYSKVMMGESCSRLAVKLLSNIALGRGAALASDTGFSDPRFGDVVIVRPMRDYSSKEITFYNRMFHVPSVFIPG...
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Sequence Mass (Da): 55825 Sequence Length: 501 Path...
A0A3G3C7T2
MLSVQLITPSSHGTAHLPRDDTDAAAGEILEFLCPFFCIGGIGDEYCDCQEKRDLDLFTDQ
Function: Probable toxin that inhibits ion channels. PTM: Mostly non-hydroxylated. Sequence Mass (Da): 6721 Sequence Length: 61 Domain: The cysteine framework is XIV (C-C-C-C). Subcellular Location: Secreted
Q9H467
MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH
Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. Sequence Mass (Da): 32009 Sequence Length: 287 Domain: The CU...
D2Y100
MKLCVVIVLLMLAMPFNGGEASRFFNQHARSQRSGMKTRGIWCDPPCPKGETCRGGECSDEFNSDVGR
Function: Probable neurotoxin with unknown target. Possibly targets ion channels. PTM: Contains 2 disulfide bonds. Sequence Mass (Da): 7524 Sequence Length: 68 Domain: The cysteine framework is XIV (C-C-C-C). Subcellular Location: Secreted
P0DTX5
MFRLGVFLLTFLLLVSMATSEYSRGRIMARASECVNECVESGHNTFHCERHCSNT
Function: Probable neurotoxin. Sequence Mass (Da): 6256 Sequence Length: 55 Domain: The cysteine framework is XIV (C-C-C-C). Subcellular Location: Secreted
P36649
MQRRDFLKYSVALGVASALPLWSRAVFAAERPTLPIPDLLTTDARNRIQLTIGAGQSTFGGKTATTWGYNGNLLGPAVKLQRGKAVTVDIYNQLTEETTLHWHGLEVPGEVDGGPQGIIPPGGKRSVTLNVDQPAATCWFHPHQHGKTGRQVAMGLAGLVVIEDDEILKLMLPKQWGIDDVPVIVQDKKFSADGQIDYQLDVMTAAVGWFGDTLLTNGAIYPQHAAPRGWLRLRLLNGCNARSLNFATSDNRPLYVIASDGGLLPEPVKVSELPVLMGERFEVLVEVNDNKPFDLVTLPVSQMGMAIAPFDKPHPVMRIQ...
Cofactor: Binds 4 Cu cations per monomer . Contains a mononuclear type 1 (T1) or 'blue' copper site, and a trinuclear copper center consisting of one type 2 (T2) or 'normal' copper site, and two type 3 (T3) or 'binuclear' copper sites . Function: Multicopper oxidase involved in copper homeostasis and copper tolerance u...
P0A9G4
MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDDSADCPIIENLSGCCHHRAG
Function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. Sequence Mass (Da): 15235 Sequence Length: 135 Domain: It contains an N-terminal DNA binding region and a C-terminal metal binding region. S...
Q4J6M6
MYPPEFSYVRAESLQEALKFLEGNDNTRPLAGGQSLIPMLKLRVLSPDYILDINRLNELNYVKTSLNGVSIGALTRYHDILSNDIVKSKVPLMHHATRTIGDMQVRNMGTIGGAISNADPASDMPVVLTALNATIILSSASGSRSVKALDFFKGPFTTDTNKGELVTQIEVPVLDGYKTVYKKVVRRAGDYALASVALAIKLKGNEIEDIKLAYGGVHDKPFRAMEVEKNVIGKKLNDDLVKDIASKVSSQINPPSDHRGSSWYRREVVKVLTMKAFKEVA
Cofactor: Binds 1 FAD per subunit. Function: Component of the glyceraldehyde dehydrogenase which is involved the nonphosphorylated Entner-Doudoroff pathway. Catalyzes the oxidation of D-glyceraldehyde to yield glycerate. When the artificial electron acceptor 2,6-dichlorophenol-indophenol (Cl2Ind) is used, the enzyme sh...
P53008
MLISKSKMFKTFWILTSIVLLASATVDISKLQEFEEYQKFTNESLLWAPYRSNCYFGMRPRYVHESPLIMGIMWFNSLSQDGLHSLRHFATPQDKLQKYGWEVYDPRIGGKEVFIDEKNNLNLTVYFVKSKNGENWSVRVQGEPLDPKRPSTASVVLYFSQNGGEIDGKSSLAMIGHDGPNDMKFFGYSKELGEYHLTVKDNFGHYFKNPEYETMEVAPGSDCSKTSHLSLQIPDKEVWKARDVFQSLVSDSIRDILEKEETKQRPADLIPSVLTIRNLYNFNPGNFHYIQKTFDLTKKDGFQFDITYNKLGTTQSISTR...
Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically . Seems to play a role in beta-1,6-glucan synthesis . PTM: N-glycosylated. Location Topology: Single-pass type II membrane protein Catalytic Activity: H2O + N(4)-(alpha-D-Glc-(1->2)...
Q9HDZ2
MTEKTSSLVFSAQYVALVHTICSFAAFFIPLALALYTHYYQVVKNEFYGYPEEWFPSVSATIGDWYPERSVFQWLIALTATPRLLVLLLWFTLSGISRPSVIITTALGVLRTALCGGWVYVTSTDDHDWHDIFMIGYLISNAPWFILVSKCSPVNSMASRIRNIGSALFVLTIFPLIYWYIQHKFKHIPGAYTVYAFFEWSLILWDILFDSALYWDFKPLVFNLHTSKTYSNPSSFATRKKEKGEHLSYAEAAAVGTQAKNIKKDSNVKCSKKQILFSLLYFSSEVYLSFVFWSVLTSLGLLVWYFPLWHMGISGYEACI...
Function: Involved in the maintenance of cell wall integrity. Required for the replacement of the diacylglycerol moiety by ceramides during GPI-anchor maturation (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 110034 Sequence Length: 971 Subcellular Location: Cell membrane
P25618
MLIINGKIIPIAHTICAFSAFFAALVTGYSLHFHKIVTNAHYTYPDEWFPSVSATIGDRYPERSIFQILIALTAFPRFLLLLGHYYLNQSKVCFLVGVLRTVSCGGWVYITSTDDHDIHDIFMITYIVLTLPWDIMITRYSSPLTSKNKGLTATIFFGTLFPMIYWYIQHSVQQRAGAYSIYAYFEWSLILLDIAFDAFAYADFKKIDIVLAFNEKPGNTSFFQIRDSSPINYGEEKSSELQKSGEKKVEKEKPVARSATGSYFRFDSFFYLLTNIFNGFLFWSNVTSLLCSIWHFPLWYMGISGYEAAILGYLGPIFLY...
Function: Involved in the maintenance of cell wall integrity. Required for the replacement of the diacylglycerol moiety by ceramides during GPI-anchor maturation. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 107883 Sequence Length: 953 Domain: The PGAP2-like region interacts with the PGAP2IP-like ...
P81717
AVDFGEAIWNPASSSNYSTASNQTSAVIMHTMEGSYAGSISWFQNPSAQVSAHYLIRKSDGQITQMVREYHQAWHAKNHNYYTIGIEHDGRAADAGNWSAAMVNASARLTKSICARRGVNCASAWKGPGYDTFHLVPDSVRVKGHGMLSGNENRYDPGKYFPWSNYYNLINGGGGNP
Function: Antibacterial activity against Gram-positive bacteria M.luteus, S.aureus, E.faecalis and P.acidilactici and Gram-negative bacterium E.coli. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 19395 Sequence...
P14892
MEIKQMLVPVSRYSVLCPYEMNPTEITFHNTYNDAPAINERNNVANNSTGTSFHIAVDDKEAIQLIPFNRNAWHAGDGTNGRGNRHSIGVEICYSQSGGARYRKAELNAVEVIAQLMIQFDIPISKVKTHQERNGKYCPHRMLDEGRVQWFKNQCANRASSIKNSNKTQETGKVEIIVNKFNKVVTYEFGTALVPEMLGMMDALGYESRIISYGDKQGLVRFETAYRQGNELDKATAWLDAKGLKYFYTKE
Function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall...
P24808
MAIKVVKNLVSKSKYGLKCPNPMKAEYITIHNTANDASAANEISYMKNNSSSTSFHFAVDDKQVIQGIPTNRNAWHTGDGTNGTGNRKSIGVEICYSKSGGVRYKAAEKLAIKFVAQLLKERGWGIDRVRKHQDWNGKYCPHRILSEGRWIQVKTAIEAELKKLGGKTNSSKASVAKKKTTNTSSKKTSYALPSGIFKVKSPMMRGEKVTQIQKALAALYFYPDKGAKNNGIDGVYGPKTADAIRRFQSMYGLTQDGIYGPKTKAKLEALLK
Function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall...
Q06320
MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYEGVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTTYQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFIQSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLKDGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES
Function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. CwlC is able to hydrolyze type A cell walls such as B.subtilis. Its main function is...
P50864
MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIYLDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKGYSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYIQDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVASSIYKGILRYFTEKGDPPE
Function: Cleaves the peptide side chain from the N-acetylmuramic acid residues in peptidoglycan. This is a step in the formation of muramic delta-lactam residues in spore cortex. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequ...
P54450
MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHAKFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGDFEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTPPKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKTANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK
Function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Could play a role in mother cell lysis with CwlC. Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl resid...
O34360
MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLHPIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYHNYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYPHLEMIPN
Function: Cleaves the linkage of the L-alanine-D-glutamic acid of B.subtilis cell wall. Sequence Mass (Da): 19113 Sequence Length: 167 Subcellular Location: Cell membrane EC: 3.4.-.-
P36550
MVKVVKNFVKVNQYTRPGLKLAGVKGIVMHYTATPGASALNERDYFNGTCIAIKRKASSAHYFVDRKEAQHIIPENEVAYHAHDKNRCYVSFLKPNANTKSISVEMCVEKDGMIHSETVQNAAELVADLCKRYGLSTNKIVRHYDVTNKICPAPWVSDSSQLTTFRKKVDSLLGNKTVSKTTSSTSQSSKSTGTILKKGASGSQVKALQKRLIAAGFSLPKYGADGSYENETVQAVKALQKKAGIAVDGIYGPATEKALAAIGAKKKKPSSNGKKTSYPLPSGIYKVKSPLMKGTGVRQIQEALAALYFYPDKGAKNNGI...
Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Sequence Mass (Da): 38996 Sequence Length: 360 Subcellular Location: Secreted EC: 3.5.1.28
Q9WUS4
MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLGVAAEDVWDDEQSAFACNTQQPGCNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRDFEKQRQKKKLYLRAQMENPELDLEEQQRVDKELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHPIYKCTQAPCPNSVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRALDGKSSSGNTENETGPPFHSTNYSGTQQCMICSSLPERISLLQANNKQQVIRVNIPRSKSMWQIPHPRQLEVDVSCGKR...
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patte...
O57474
MGDWSALGRLLDKVQAYSTAGGKVWLSVLFIFRILVLGTAVESAWGDEQSAFKCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKAVQNDGGDVELHLKKIELKKFKHGLEEHGKVKMKGSLLRTYIFSIIFKSICEVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVSLFSLLLNIIELFYVLFKRIKDRVKSRQNTQFPTGTLSPTPKELSTTKYAYYNGCSSPTAPLSPMSPPGYKLATGERTNSCRNYNKQANEQNWANYSTEQNRLG...
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity). Location Topology: Multi-pass membran...
P23242
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRM...
Function: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by en...
P0DL31
CKGQSCSSCSTKEFCLSKGSRLMYDCCTGSCCGVKTAGVT
Function: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin inhibits rat Cav2.2/CACNA1B calcium channels in a dose-dependent manner (EC(50)=2.8 uM), whose effect is partially reversed after washing. In vivo, when injected into mice, it shows both an anal...
A0A125S9G0
MRLTTMHSVILMLLLVFAFDNVDGDEPGQTARDVDNRNFMSILRSEGKPVHFLRAIKKRDCTGQACTTGDNCPSECVCNEHHFCTGKCCYFLHA
Function: Probable neurotoxin. PTM: Contains 4 disulfide bonds. Sequence Mass (Da): 10583 Sequence Length: 94 Domain: The cysteine framework is C-C-C-C-C-C-CC. Subcellular Location: Secreted
E9QJ73
MDNSTTAAEVSAPTDYDYNSTSYDDDNPYAAPCSLTETWNFLGRFAPVAYILVFILALVGNILVLCVIRRYRQSRHSPCSFSLTDTFLLHLAVSDLLLAATLPFFAVEWISEWVFGKVMCKITGALFSLNVYCGVLFLACISFDRYLAIVHAINISWRRKTCHAQLACAFIWVICLGLSMVDMHFRDLVEIPGMNRMVCQIVYSEQYSKQWQIGMQLVSMVLGFILPLLVMLYCYLHIFKALCHATRRQKRRSLRLIISLVIVFVISWAPYNALRMTDSLQMLGVIVKSCALNNVLDVGILVTESLGLAHCALNPLLYGL...
Function: Receptor for the C-X-C chemokines cxcl11.1 and cxcl11.6 . Promotes macrophage chemotaxis to sites of bacterial infection . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 42263 Sequence Length: 378 Subcellular Location: Cell membrane
Q9YGC3
MDGFSGGIDINIFDGNSTENGSGDFEDFIEPCFMHENSDFNRIFLPTIYSFIFLLGIIGNGLVVVVMGYQKKSRTMTDKYRLHLSVADLLFVFTLPFWSVDAAIGWYFKEFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLADKVVYAGVWLPALLLTVPDLVFARVSDENGQFVCDRIYPIENRETWTVGFRFLHITVGLILPGLIILICYCVIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVCLTTDTFMLLGLVKGDCIWENTLHMAISITEALAFFHCCLNPILYAFLGAKFKTSA...
Function: Receptor for the C-X-C chemokine cxcl12/sdf-1. Transduces a signal by increasing the intracellular level of calcium ions. Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cells during gastrulation. May play a role in the migration of embryonic presumptive primordial germ cells (pPGC...
A0A0R4I952
DGECGDKDEPCCGRPDGAKVCNDPWVCILTSSRCENP
Function: This toxin reduces the outward currents that are due to the opening of voltage-gated potassium channels in DRG neurons. In addition, leftward shift in the presence of this toxin is observed in averaged normalized conductance-voltage plot of outward sodium currents (Nav1.2/SCN2A). Sequence Mass (Da): 3970 Sequ...
Q5K8R6
MPLNLPFSSPLKLPLPRRFIILILSASILILFLHTFAPSTLPPVLTPNLPHHEPDASYFSPSKWLPPILNPNAPTRPLEFDEDGQCLFLSPFDALSAAEKARARVLSLDEISPGIVRADAPPAEGTDADPDFDDEFSELSNATRKMPAGLTHPILGLLRDGEAKWNSMVTMQSQTLEQAVDVYMDRWGRRPPKGFDEWWHFAKANNVLLPDEYDPIMNSLLPFYALPIDTLKERLVEAEKIPETFTLIVHDGKVELKWNDDYSRDTWWASRPRADSQINLMEPFIKHIGTFRATFTIHDQPSILLDHERQEELLTAARHG...
Function: Beta-1,2-xylosyltransferase that plays a key role in capsule polysaccharide synthesis by transferring xylose to alpha-1,3-dimannoside in a beta-1,2-linkage. Also mediates glycosylation of glycosphingolipids; constitutes the unique xylosyltransferase responsible for adding xylose to glycosphingolipids. Locatio...
Q9P0U4
MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSSEPRDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPAL...
Function: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. PTM: May be regulated by proteolysis. Sequence Mass (Da): 75712 Sequence Length: 656 Domain: The acidic domain carries the potential to activate transcription. Subcellular Location:...