ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
A1A652
MSATGNKVFAPAIFFIAAREALEASLVIGILSGMLENLVVHTKSAEDLAAHDSLTESEKHEVEQKKRALVRKLRKIVLLGALTGLLIAFAIGAAFLAVFYTQVNDLYGKAEELWEGIFNLVAVLLITPMSLAILRAGNSKRKWKRKLENAFSHQNIQPNHRRDEEGEATVVNANHSDDSASASSSSARQAAEEEAGTKTTRTEKLNPLEAVDVVPSMSGDQRRKRGGLRGLFSKPSGAVNDLKLRMNRGTLALFTIPLITTLREGLEGVVFIGGVSLGLPATSIPLPAIVGLAVGLGIGFLIFRSGNLVSVRIFLVFSTC...
Function: Permease for high affinity iron uptake . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 53084 Sequence Length: 486 Subcellular Location: Cell membrane
Q9ZQG8
MATVRISSTSMTKAVLRSQTTNKLITNKSYNLSVGSTKRVSRSFGLKCSANSGGATMSAVYKVKLLGPDGQEDEFEVQDDQYILDAAEEAGVDLPYSCRAGACSTCAGQIVSGNVDQSDGSFLEDSHLEKGYVLTCVAYPQSDCVIHTHKETELF
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 16634 Sequence Length: 155 Subcellular Location: Plastid
P27788
MSTSTFATSCTLLGNVRTTQASQTAVKSPSSLSFFSQVTKVPSLKTSKKLDVSAMAVYKVKLVGPEGEEHEFDAPDDAYILDAAETAGVELPYSCRAGACSTCAGKIESGSVDQSDGSFLDDGQQEEGYVLTCVSYPKSDCVIHTHKEGDLY
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 16123 Sequence Length: 152 Subcellular Location: Plastid
P14938
ATYKVKFITPEGEQEVECDDDVYVLDAAEEAGIDLPYSCRAGSCSSCAGKVVSGSVDQSDQSFLDDDQIAEGFVLTCAAYPTSDVTIETHREEDMV
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 10338 Sequence Length: 96 Subcellular Location: Plastid
P49522
MATYKVTLLSEEHDIDATIDCNDDVFLLDAAEEQGIELPYSCRAGACSTCAGKVTEGDIDQSEQTFLDDDQVGAGFVLTCIAYPKSDCTVLVHQEDELY
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Sequence Mass (Da): 10789 Sequence Length: 99 Subcellular Location: Plastid
P21149
MLSQVCRFGTITAVKGGVKKQLKFEDDQTLFTVLTEAGLMSADDTCQGNKACGKCICKHVSGKVAAEDDEKEFLEDQPANARLACAITLSGENDGAVFEL
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. It links pyruvate:ferredoxin oxidoreductase to hydrogenase. Sequence Mass (Da): 10675 Sequence Length: 100 Subcellular Location: Hydrogenosome
Q84VG7
MSDSDMDIDDDEVEQKVQVHTIVRESELFDKPPIQASNSHNDVKRHSVTTPLDEQSKIIKEQAFAQDNGTLPRFPAPGIPPRSFFTGGGGNEPEQKRAALPCKFFAKGWCFNGVSCKFLHVKENSNCTSQQLAENSMAGNGGIRSDLERRILDSREGVRVSQLSENGVTSLPTREDISFMNPQRVFSSMSFVNPPGSQRVFPFNNEMRFMPSFENIRRESLKQTYGADFTDNRSLVINNANSFALRSSFVHEHRPSISSYLKTDMGSAGPAWTGSLSSSVPMNDRASTVGDFENGNSLSGSGSLPTLQGVAVSSDKGAEA...
Function: Transcriptional activator involved in the FRIGIDA-mediated vernalization pathway, but not in the autonomous flowering pathway. Acts cooperatively with FRI (FRIGIDA) or FRL1 (FRIGIDA-LIKE 1) to promote FLC (FLOWERING LOCUS C) expression. Required for the stabilization of the FRI-C complex. Sequence Mass (Da): ...
P70377
MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEHFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST
Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules . Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching . Plays a crucial role in neuron po...
Q5AP52
MKISNLIPAYLLPFSLFCQVLGAPTNGKRGNVVVVKVKTTVQQTQTDIQTISEATGTTTNYLINTSTETFTRYTATVTSTVYGVPHTYTTVATTPVSAADVIPNSENEVKSSPTESPVEQETSTSSTSVATTTTPVAKNPVSSQETSTPTPVPPETTSTSSSLLSSSQQTTTLAQVSETAINDTTESSGPTITGSVSSQTTDSWIIENISTVTSDGTCFVNYDYYYATETDDAEETTTLTSTITTTVTLN
Function: Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth. Location Topology: Lipid-anchor Sequence Mass (Da): 26401 Sequence Length: 250 Subcellular Location: Secreted
Q91V87
MTRSPALLLLLLGALPSAEAARGPPRMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAEDAGVYVCKATNGFGSLSVNYTLIIMDDISPGKESPGPGGSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDIMWMKDDQTLTHLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNKAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL...
Function: Has a negative effect on cell proliferation. Location Topology: Single-pass membrane protein Sequence Mass (Da): 57013 Sequence Length: 529 Subcellular Location: Cell membrane
P09769
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ...
Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosi...
I1RC73
MPPRRSHKKSRAGCRRCKNRKIKCDEVHPRCGNCAKHGVPCDFSNPDVLEELAISTNTSTESVGAPTPSPAPTVNFNSAPRTPLTRPRAPSSPARAPRPNPSPPTSVYSQPSISSSTNTIDHGERMLELRLMHHYTNVTSKTLLTNSPAAEDIWQRAVPQMAFSGNGKTYLADAILSVAALHLRSMSPNDKALVRASHAYSASSLSAFGASLGAGITPENAEALFLTATLIAFQASASRIFVKDDGDAAPGDPTVRYVPPLSWFHAFQGVKTVVANSWQWIHHSDIVKVIIDSQPSFQLNLNPRSPDSFFGHMLEGLADE...
Function: Transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences . Positively regulates the expression of ergosterol biosynthesis genes including CYP51A and CYP51B encoding the sterol 14-alpha demethylase, and ERG6A and ERG6B encoding the sterol 24-C-methyltransferase . PTM: Phosp...
O44827
MSEKSRSDTSATASLSDSSKSPSSYSTPGTTTQKIIFPDGKLTKCLAFSAFVITLASFQFGYHIGCVNAPGGLITEWIIGSHKDLFDKELSRENADLAWSVAVSVFAVGGMIGGLSSGWLADKVGRRGALFYNNLLALAAAALMGLAKSVGAYPMVILGRLIIGLNCGFSSALVPMFLTEISPNNLRGMLGSLHQLLVTIAILVSQIFGLPHLLGTGDRWPLIFAFTVVPAVLQLALLMLCPESPKYTMAVRGQRNEAESALKKLRDTEDVSTEIEAMQEEATAAGVQEKPKMGDMFKGALLWPMSIAIMMMLAQQLSGI...
Function: Facilitative glucose transporter that plays a role in glucose metabolism and regulation of longevity. May also play a role in lipid metabolism. Glucose transport activity of isoform a is competitively inhibited by mannose, galactose and fructose, suggesting ability to transport also other hexose sugars. Locat...
O44616
MNAVVASQNKNDRSFSNMESESSSNVEKSEKENHHQSLPDENWTPFLFFCISSIALASFQDGFQIGCINAPGPLIIDWIKKCHFELFGEVLSQYQADFIWSVAVSMFSVGGMFGSFCSGFLADKFGRKSTLLYNNILALLAAVCLSTSKLFNFYPMIVFGRFLVGLNCGITSGLVPMFLTELAPANLRGKCGSFHQLNISVAIVLSQALGLPQIFGTQVGWPYIFACVAIPTFLQLATIPFCVESPKYLISKLNDREEARRILEKLRGHTKVDEELEHMVQETMVTVEPLHQPGYVSLFKGDNQWPMIVSILMMFSQQFS...
Function: Appears to have no transport activity for glucose. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 57609 Sequence Length: 516 Subcellular Location: Cell membrane
Q9SRR2
MDGLCYVIFIIFSLLSCAFSPLSYASPATFSRRHLLQAPVTDPSTFSPPFFPLYSSTSPPPPPSPPQPLPPPAPTFATFPANISALVLPRSPKPQTPSRTLLIPAISAVLAAATLIALAFFFYGRWRGQTSHFKDESKSLASDISQSQQQTLPCPPPRNNNTQNKLSVAPSTSDVLYLGNVVTSSGSGFVKPESPDISPLPPLPARSFLLQHHSEANLDEEEEDDDFYSPLASIAGQESRDRRINPYSNCSCSISSHSDSPAMSPSAAMSPPMNSTAPHWSTNQNTHSPSSPERTVRNNKRYGGQSLRMFSLWNQNLGFP...
Function: Might be involved in the organization and polarity of the actin cytoskeleton. Location Topology: Single-pass membrane protein Sequence Mass (Da): 93012 Sequence Length: 841 Subcellular Location: Membrane
Q9MA60
MVYFRQIFLMIIVVSLHCCKVRFFCIVANAKELDDWKVLTVENGERYRTHVGRYAGEEGGEKIKLRVLEKFRALLDLIKPSTSRRRNLAESASFSPWPAPSPSPFPNGGPIESPAYPPAPPRPIPPHLRRPLPQRTHPLEQPEIQRRKHEKGGTFKKILVPVVASTASAIGFVVCVVGVFCLCARRKRKMNGKTLSFKRKKGKSQSSTRKVSVNPTLDFLYLNSLGVDLERQNSVSVKEIRETEKDLNGINGGLLEEEVKRSIETEISHDWDNASSYSTKEIVSVHENDEEQTVNSVSVPVVVINDSSDDDESFHSVGGG...
Function: Might be involved in the organization and polarity of the actin cytoskeleton. Location Topology: Single-pass membrane protein Sequence Mass (Da): 98535 Sequence Length: 884 Subcellular Location: Membrane
P02671
MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTAT...
Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of ...
Q7M3I9
TKDEGTFIAEGGGVR
Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of ...
P14462
ADGSDPAGGEFLEAGGGVR
Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of ...
Q6CZ45
MNPHYARLVTLAAVSATAVALVLFVMKVFAWWHTGSVSLLASLVDSLVDIAASLVNLLVVRYSLQPADTEHAFGHGKAESLAALAQSMFISGSALFLILTGLQHSLEPQTLHAPEVGMWVTLIALVATLLLVSFQRWVVKHTHSQAVRADMLHYQSDLLMNGAILVALALSWKGITRADSLFALGIGVYILYSALRMGYDAVQSLLDRALPDEEHRAIAEVIVNWPGIRGAHALRTRRSGPTRFIQLHLEMDDALPLAEAHQIADDLEQALRKQFPGADIIIHQDPVSAVPENQRGRLTA
Function: Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux. Catalytic Activity: H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32762 Sequence Length: 300 Subce...
P30130
MSYLNLRLYQRNTQCLHIRKHRLAGFFVRLVVACAFAAQAPLSSADLYFNPRFLADDPQAVADLSRFENGQELPPGTYRVDIYLNNGYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVAGMNLLADDACVPLTTMVQDATAHLDVGQQRLNLTIPQAFMSNRARGYIPPELWDPGINAGLLNYNFSGNSVQNRIGGNSHYAYLNLQSGLNIGAWRLRDNTTWSYNSSDRSSGSKNKWQHINTWLERDIIPLRSRLTLGDGYTQGDIFDGINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQVTIKQNGYDI...
Function: Involved in the export and assembly of FimA fimbrial subunits across the outer membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 96482 Sequence Length: 878 Subcellular Location: Cell outer membrane
Q9FJL3
MEDDFDTQNQFPEEEPEEMDMDLPDNDEADSAPYLKIGEEMEIGKSGLKKKLVKECEKWDTPENGDEVEVHYTGTLLDGTKFDSSRDRGTPFKFTLGQGHVIKGWDLGIKTMKKGENAIFTIPPELAYGETGSPPTIPPNATLQFDVELIAWRSVKDICGDGGVSKKIIVEGEKWEKPKDLDEVYVKYEARLEDGTIVGKSDGVEFTVKEGHFCPALSKAVKTMKRGEKVLLTVKPQYGFGEFGRPASDGLQAAIPPNATLQIDLELVSWKTVVEVTDDRKVIKKILKEGEGYERPNEGAIVKLKLIGKLQDGTTVFVKK...
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Co-chaperone that negatively modulates thermotolerance by interacting with FKBP62 and decreasing the HSFA2-mediated accumulation of chaperones of the small-HSPs family. Plays ...
P81104
XGESWETPETGDEVE
Function: PPIases accelerate the folding of proteins during protein synthesis. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 1676 Sequence Length: 15 EC: 5.2.1.8
Q43207
MDDDFDIPAGDDMMMGDGMGDFGGAEGPGMKVGEENEIGKQGLKKKLLKEGEGWDTPEVGDEVEVHYTGTLLDGKKFDSSRDRDDTFKFKLGQGQVIKGWDQGIKTMKKGENALFTIPPELAYGESGSPPTIPANATLQFDVELLSWTSVRDIAKDGGIFKKILKEGDKWENPKDPDEVFVKYEARLEDGTVVSKSEGVEFTVKDGHLCPALAKAVKTMKKGEKVLLAVKPQYGFGEMGRPAAGEGGAVPPNASLVIDLELVSWKTVTEIGDDKKILKKVLKEXEGYERPNEGAVVTVKITGKLQDGTVFLKKGHDEQEP...
Function: PPIases accelerate the folding of proteins during protein synthesis. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 62058 Sequence Length: 559 EC: 5.2.1.8
O08437
MNNFLKVSLLAAAVAVSLTACQKDEKTAANTAEVKAEASKPAEAPKAEAKSFEEQSGYAIGLSMGRYIANTLERQQELGIKLDNSVILKGVTDGLGKEAKMTDEEIQKVLQQYDAKINELTKAKADKDAVENQKKGEEYLAANAKKEGVKSTESGLQYQVEKMGTGAKPKATDIVKVHYTGTLTDGTKFDSSVDRGEPATFPLNQVIPGWTEGVQLMPVGSKFKFFLPSKLAYGEHGAGSIPANAVLVFDVELLAIEKPAADGDNAKK
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (...
P57599
MILYVPKSFSISAPISDIHLQSVLETKNTFHNNNEKLGYILGLSFGNYVNQTFEKQKKIGIELDRNSLLKGIQDAISGNLKLSHQDISSGLKELEKKLKHATKIQLKKNAKENFIQGELYMKNFSKLKGVKKTSSGLLYLLERAGEGEALKDETKITVHYKGTLINGLEFDNSYKRGRPVSLRLKDVILGWKEGLKYIKKGGKIKLVIPPNLAYGTEEVNGIPANSTLIFDIELLDVVNGV
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 26946 Sequence Length: 241 EC: 5.2.1.8
P45523
MKSLFKVTLLATTMAVALHAPITFAAEAAKPATAADSKAAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKDAADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLVFDVELLDVKPAPKADAKPEADAKAADSAKK
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 28882 Sequence Length: 270 Subcellular Location: Periplasm ...
Q9JYI8
MNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKKVN
Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Location Topology: Lipid-anchor Sequence Mass (Da): 28894 Sequence Length: 272 Subcellular Location: Cell membrane EC: 5.2.1.8
P0A9L3
MTTPTFDTIEAQASYGIGLQVGQQLSESGLEGLLPEALVAGIADALEGKHPAVPVDVVHRALREIHERADAVRRQRFQAMAAEGVKYLEENAKKEGVNSTESGLQFRVINQGEGAIPARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNGVIPGWIEALTLMPVGSKWELTIPQELAYGERGAGASIPPFSTLVFEVELLEIL
Function: PPIases accelerate the folding of proteins (Probable). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides . Displays a preference for substrates with a lysyl residue in the P1 position . Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (...
P74838
MSDVVETLRLPNGATVAHVNAGEAQFLYREIFTDRCYLRHGVELRPGDVVFDVGANIGMFMLFAHLEHPGVTVHAFEPAPVPFAALRANAVRHRVAGRVDQCAVSDEAGVRRMTFYPDATLMSGFHPDAAARKELLRTLGLNGGYTAEDVDMMLAQLPDTGEEIETSVVRLSDVIAERGIAAIGLLKIDVEKSERRVLAGVEDADWPRIRQVVAEVHDVDGALGEVVALLRGHGFTVVAEQDPLFAGTEIHQVAARRTAG
Function: Involved in the biosynthesis of FK506, which is a macrolide antibiotic with immunosuppressant activity. Catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 31-O-position of 31-O-demethyl-FK506. Also catalyzes the methylation of 31-O-demethylimmunomycin, the C31 transmethylation reacti...
Q9KID9
MTDAGRQGRVEALSISVTAPYCRFEKTGSPDLEGDETVLGLIEHGTGHTDVSLVDGAPRTAVHTTTRDDEAFTEVWHAQRPVESGMDNGIAWARTDAYLFGVVRTGESGRYADATAALYTNVFQLTRSLGYPLLARTWNYVSGINTTNADGLEVYRDFCVGRAQALDEGGIDPATMPAATGIGAHGGGITCVFLAARGGVRINIENPAVLTAHHYPTTYGPRPPVFARATWLGPPEGGRLFISATAGILGHRTVHHGDVTGQCEVALDNMARVIGAENLRRHGVQRGHVLADVDHLKVYVRRREDLDTVRRVCAARLSST...
Function: Involved in the biosynthesis of the macrocyclic amino acid-linked polyketides FK506 and FK520 which are potent immunosuppressants that prevent T-cell proliferation through initial binding to the immunophilin FKBP12. Catalyzes the hydrolysis of chorismate via a 1,4-conjugate elimination of water to yield (4R,5...
Q554J3
MGVEITIIKEGKGNIPPVGSNVTVHHAGTLTNGTVFDSSRKRGQPFNFKLGAGQVIKGWDEGVAKMKVGETSKLTISPDFGYGARGAGGVIPPNATLVFEVELITFK
Function: PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 11242 Sequence Length: 107 EC: 5.2.1.8
Q4WHX4
MRILLLSALFLSLTTLVLSADLGIEKTHVVECNRKTTKGDTVHMHYRGTLAADGSEFDSSYGRNQPLKFKLGAGRVIKGWDEGLLDMCVGEKRTLTIPPEYGYGERGIGPIPGGATLIFETELVQIEGVNNDEL
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 14638 Sequence Length: 134 Subcellular Loca...
Q2UPT7
MRFSIFSTLLVSLATLSTAAELGIEKTHEVECTRKTVKGDTVQMHYKGTLQSDGSEFDSSYKRNSPLKFKVGSGMVIKGWDEGLLDMCIGEKRTLTIPPEYGYGSRGVGPIPGGATLIFETELVGIDGVSKDEL
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Catalytic Activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Sequence Mass (Da): 14524 Sequence Length: 134 Subcellular Loca...
O17798
MSNISWYRHCSVRLQLVTLALFLLLGSASLGSAHIDEEFEDDVTTTISSIASPMRRTYTNEWAVRIAGGKVEEANRLANKYGYTNLGPIIPGDEYYLFRDDRKKSRSSRKTRSLSANQLQHEEDVMWMEQQVAKRRVKRGYRRIRRHTDDNDIFEEDDDGTQISKSRNRKHPDPNDPLWTDMWYLNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPNYDERASYDVNDRDNDPMPRYEFSDENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRMLDGDVTDAVEAASVGHNADYIDIYSA...
Cofactor: Binds 3 calcium ions per subunit. Function: Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif . During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons . Together with chin-1 and cdc-42, plays a rol...
Q9H9S5
MRLTRCQAALAAAITLNLLVLFYVSWLQHQPRNSRARGPRRASAAGPRVTVLVREFEAFDNAVPELVDSFLQQDPAQPVVVAADTLPYPPLALPRIPNVRLALLQPALDRPAAASRPETYVATEFVALVPDGARAEAPGLLERMVEALRAGSARLVAAPVATANPARCLALNVSLREWTARYGAAPAAPRCDALDGDAVVLLRARDLFNLSAPLARPVGTSLFLQTALRGWAVQLLDLTFAAARQPPLATAHARWKAEREGRARRAALLRALGIRLVSWEGGRLEWFGCNKETTRCFGTVVGDTPAYLYEERWTPPCCLR...
Function: Catalyzes the transfer of a ribitol 5-phosphate from CDP-L-ribitol to the ribitol 5-phosphate previously attached by FKTN/fukutin to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglyc...
O75072
MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSTKNGAGLSKSKGSRIGFDSTQWRAVKKFIMLTSNQNVPVFLIDPLILELINKNFEQVKNTSHGSTSQCKFFCVPRDFTAFALQYHLWKNEEGWFRIAENMGFQCLKIESKDPRLDGIDSLSGTEIPLHYICKLATHAIHLVVFHERSGNYLWHGHLRLKEHIDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLEVLIPKDPMHFVEEVPHSRFIECRYKEARAFFQQYLDDNTVEAVAFRKSAKELLQLAAKTLNKLGVPFWLSSGTCLGWYRQCNIIPYSKDVDL...
Function: Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) . This constitutes th...
Q2IQP0
MSPLTRIALALAASAALVLALTACGPAHVAGYVPKRRDYAVPDASGQDTQAASAGSTWREGRAASMLYTDARALRENDLVVVRIEEIADAKRSADTDLTRRSELNASIEAFLTSLSTPYALKGGADSGFKGLGSTARTERLTATVPAVVRKVLPNGNLFIEGHRVVLVNAEEQHFYISGVVRPIDIDQENGVKSSMVADAEIEFTGRGVLSDNQRQGWLSRLLGWFWPF
Function: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. Location Topology: Lipid-anchor Sequence Mass (Da): 24659 Sequence Length: 229 Subcellular Location: Cell outer membrane
O67609
MLYLFFALIFIISCSTKVESKKKYTYSFPKTYKEEKPTRGSLFKSPQSAYLYGSVRASEVGDVIYIRVIESINAIESVSTNVGRSTSFSNAISSFFGVHPATLKNLGAGGKSSFASKGGSKFQQSGVLTTTLAGRVVKVFPNGTMLVEAKKYIEVNGVKREFLLRGIVRPEDIDSNNTVTSDKIADMEIFFEGRGYIVRGGEPGWLAKIFAILFPF
Function: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. Location Topology: Lipid-anchor Sequence Mass (Da): 23767 Sequence Length: 216 Subcellular Location: Cell outer membrane
A8IPJ4
MKPVILATASALLLAACQTNSYDSLAYGPTLTPVGQGLEAGRMPVPQPFQQAKERTFRSAYNLNSQSMYRALRAAAVGDVIRITIDIDDKAQLDNNTNRSRKSASDVGFASALNLSGFQSGSTSGSASGNLGLTGDTSTDGKGKIDRSEKLRLSLAAVVTEVMPNGNLVINGSQEILVNYEVRVLTLGGIVNPLDVTSNNTVAYDKVAEARISYAGRGRLNDVQQPAWGQRLFDAVNPM
Function: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. Location Topology: Lipid-anchor Sequence Mass (Da): 25383 Sequence Length: 239 Subcellular Location: Cell outer membrane
A1K945
MKALALLAVLLLSGCASIYSTPPTAIHQPMSARPDMRAQAVPATGSIYQPSQARPLFEDRRARNVGDIITINLVERNTAQKSANASATRGSAITGGISLTAPNIASLANAKLNGLQADVGLDSDFSGEGAAAANNVFNGTISVTVIDVYPNGNLLVSGEKMVAINQGNEFIRFSGVINPTTVTAANTVQSTQVADARIEYRGSGFIDESNTMGWLQRFFVAIAPF
Function: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. Location Topology: Lipid-anchor Sequence Mass (Da): 23588 Sequence Length: 225 Subcellular Location: Cell outer membrane
Q7WJD2
MMLKTVLRLPVCAALLALAAGCAMIPPEPVVTGPLTAPPPPPPQPSARPNGSIYQPSAYGNYPLFEDRRPRNVGDIVTIVLEEKTNAAKGVATNTSRDGSATLGVAAAPRFMDGIINDKLDTDISGGNTANGTGKSSANNTFTGTITTTVIGVLPNGNLQIAGEKQIAINRGSEYVRFSGVVDPRSITGSNTVSSTRVADARIEYRSKGVMDEVQTMGWLQRFFLIASPF
Function: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. Location Topology: Lipid-anchor Sequence Mass (Da): 24206 Sequence Length: 230 Subcellular Location: Cell outer membrane
Q2YJ67
MNKAILAVAMVLLLAGCATKPEEIGRAPDLSPVAAHLGMQNNPQFNGYPARPGKASYSLWDQRSTNFFKDPRAATPGDVLTVIISINDRANLDNKTDRERVSKGIYGGGGSFATSSITGAAAGGDMDASVNTHSDSKSKGKGTIERSEDIRLQIAAIVTDTLPNGNLIIRGSQEVRVNNELRVLNVAGVVRPRDISGNNTISYDKIAEARISYGGRGRLSEIQQPPYGQQILDQFSPF
Function: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. Location Topology: Lipid-anchor Sequence Mass (Da): 25471 Sequence Length: 238 Subcellular Location: Cell outer membrane
P26477
MSIDRTSPLKPVSTVQTRETSDTPVQKTRQEKTSAATSASVTLSDAQAKLMQPGVSDINMERVEALKTAIRNGELKMDTGKIADSLIREAQSYLQSK
Function: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA. Sequence Mass (Da): ...
O25026
MKKSKHLKRPYLKRSHLKHSDKASSFKGLLKKEDNVISLENFKPKESEDLLENFSNKKDMQELLGLLNQFILQSYKVEKEFKDYKALYEWVIEILPQAIWVVNENGSFFYKNSLANQSHEVFNKAKLENFNTEIEHENKSYLVQQNSIQGKQIITATDISAQKRQERLASMGKISAHLAHEIRNPVGSISLLASVLLKHANEKTKPIVVELQKALWRVERIIKATLLFSKGIQANRTKQSLKTLESDLKEALNCYTYSKDIDFLFNFSDEEGFFDFDLMGIVLQNFLYNAIDAIEALEESEQGQVKIEAFIQNEFIVFTI...
Function: Member of the two-component regulatory system FlgR/FlgS that induces the transcriptional induction of the genes needed in motility and flagellar biogenesis . Also plays an essential role in bacterial survival at pH 2.5 independently of FlgR . Functions as a sensor protein kinase which is autophosphorylated at...
O67265
MRGKEFWIILAVVLILSAIIIPIPALLLDLLLTLSITFSLTVLLLTFFIKNPLEFSSFPSVLLLGTLLRLSLNIAAARRILLHGHEGTHAAGKVIEAFGKLVAGGDVVVGLIVFLIFIVINFIVITKGAERISEVAARFTLDALPGKQMSIDADLNAGLITEEEAKRRRQELEKEANFYAAMDGASKFIRGDAIAALIILFLSLVGGLLIGIGIRGMDLASAVKTYTILSIGEGLASQVPALLLSTAAGVLTTKMSSRENLGEAISEELTKQPRALLFSAGVLGFIGLIPGLPTLPFLAMSAILAGAYYLVQQSLKEREL...
Function: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 75392 Sequence Length: 678 Subcellular Location: Cell membrane
P35620
MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLLTTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNVLVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEAKHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAASHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAATIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEIL...
Function: Involved in the export of flagellum proteins. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 73977 Sequence Length: 677 Subcellular Location: Cell membrane
Q44909
MLDARKNSILGYLGLNNKSDLIISVGLIFVVAGFILPLPAVILDVLITVNLVISLLIILIVLYSKRSLDFSVFPTLLLVMTIFGLVLNISSTRLILTKGINFDGQMIRTFGTFVVGSSGIQGLVIGFIIFIIIIAVQFIVITKGATRVAEVAARFALDALPGKQMAIDSAYSSGNLTEEEATRQKNDLQSEVNFYGAMDGASKFVSGNVKVGFLITLINILGGLLVGITLQGLNFNEALNNYVSLTVGDGLVSQLPSLLISTSTGLIVTRSISKNSFGGEIFDQFTNHLGIYWIVSGFLLFLAFLPGFPTLILMFLSLSI...
Function: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 76969 Sequence Length: 697 Subcellular Location: Cell membrane
O25119
MATKLTPKQKAQLDELSMSEKIAILLIQVGEDTTGEILRHLDIDSITEISKQIVQLNGTDKQIGAAVLEEFFAIFQSNQYINTGGLEYARELLTRTLGSEEAKKVMDKLTKSLQTQKNFAYLGKIKPQQLADFIINEHPQTIALILAHMEAPNAAETLSYFPDEMKAEISIRMANLGEISPQVVKRVSTVLENKLESLTSYKIEVGGLRAVAEIFNRLGQKSAKTTLARIESVDNKLAGAIKEMMFTFEDIVKLDNFAIREILKVADKKDLSLALKTSTKDLTDKFLNNMSSRAAEQFVEEMQYLGAVKIKDVDVAQRKI...
Function: One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation. Required for flagellum synthesis an...
Q51464
MSENRLAAKLTKVDKAAILLLSLGETDAAQVLRHMGPKEVQRVGVAMASMRNVHREQVEQVMGEFVEVVGDQTSLGVGADGYIRKMLTQALGEDKANNLIDRILLGGSTSGLDSLKWMEPRAVADVIRYEHPQIQAIVVAYLDPDQAAEVLSHFDHKVRLDIVLRVSSLNTVQPSALKELNLILEKQFAGNSNATRTTMGGVKRAADIMNYLDSSIEGQLMDSIREVDEDLSGQIEDLMFVFDNLADVDDRGIQALLREVSSDVLVLALKGSDEAIREKVFKNMSKRAAELLRDDLEAKGPVRVSEVEGAQKEILTIARR...
Function: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation ...
P0A1K0
MSNLSGTDKSVILLMTIGEDRAAEVFKHLSTREVQALSTAMANVRQISNKQLTDVLSEFEQEAEQFAALNINANEYLRSVLVKALGEERASSLLEDILETRDTTSGIETLNFMEPQSAADLIRDEHPQIIATILVHLKRSQAADILALFDERLRHDVMLRIATFGGVQPAALAELTEVLNGLLDGQNLKRSKMGGVRTAAEIINLMKTQQEEAVITAVREFDGELAQKIIDEMFLFENLVDVDDRSIQRLLQEVDSESLLIALKGAEPPLREKFLRNMSQRAADILRDDLANRGPVRLSQVENEQKAILLIVRRLAETGE...
Function: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation ...
P95715
MSNLTGTDKSVILLMTIGEDRAAEVFKHLSQREVQTLSAAMANVTQISNKQLTDVLAEFEQEAEQFAALNINANDYLRSVLVKALGEERAASLLEDILETRDTASGIETLNFMEPQSAADLIRDEHPQIIATILVHLKRAQAADILALFDERLRHDVMFVSHLWRRAASALAELTEVLNGLLDGQNLKRSKMGGVRTAAEIINLMKTQQEEAVITAVREFDGELAQKIIDEMFLFENLVDVD
Function: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation ...
Q9WY63
MPEKKIDGRRKAAVLLVALGPEKAAQVMKHLDEETVEQLVVEIANIGRVTPEEKKQVLEEFLSLAKAKEMISEGGIEYAKKVLEKAFGPERARKIIERLTSSLQVKPFSFVRDTDPVQLVNFLQSEHPQTIAVVLSYLDPPVAAQILGALPEELQTEVLKRIALLERTSPEVVKEIERNLEKKISGFVSRTFSKVGGIDTAAEIMNNLDRTTEKKIMDKLVQENPELADEIRRRMFVFEDILKLDDRSIQLVLREVDTRDLALALKGASDELKEKIFKNMSKRAAALLKDELEYMGPVRLKDVEEAQQKIINIIRRLEEA...
Function: One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). Location Topology: ...
Q9X4Q9
MAKDNKDGGEVVESTIDISEIPGEEKAAILLLSLNEEDAAGIIRHLEPKQVQRVGSAMARAKDLSQTKVSAVHRAFLEDIQKYTNIGMGSEDFLRNALVAALGADKANNLVDQILLGTGSKGLDSLKWMDPRQVASIIINEHPQIQTIVLSYLEPDQSAEILAQFAQRDALDLLMRIANLEEVQPSALAELNEIMEKQFAGQAGAQAAKIGGLKAAADIMNYLDNNIESVLMEGMREKDEDLATQIQDLMFVFENLVEVDDQGIQKLLRDVPQDVLQKALKGADDTLREKIFKNMSKRAAEMMKDDLEAMPPIKVSDVEA...
Function: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation ...
O34171
MTMPESMLSESKLSGWAISPKLAQLASLAGHYADPEFSVAHGGHVRTIAAGHYTVSGLSRHVRLGEFVAHRSATGIHLGEVVRVEPDICYVCPIEPGEPIGIHDTVIRKGAFRVSPDESWCGRTINALGEPIDGQGPLASGIVRRSISNNAPPSMTRKRVETPFKTGVRAIDIFSPLCLGQRLGIFAGSGVGKSTLLSMLAKADAFDKVVIALVGERGREVREFIEDTMGDNMSKSVAVVATSDESPMLRKMAPLSAVTIAEHFRDQGDNVLLIIDSVTRFAHAIREVAVASGEPPVARGYPASVFTELPRLLERAGPGA...
Function: Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. Catalytic Activity: ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate Sequence Mass (Da): 50807 Sequence Length: 473 Subcellular Location: Cytoplasm EC: ...
O67531
MKGIRRNLQKSYLKRCSEMYLRGLKVSGEIVSAKGIYLEAILPFANIGNEVEIQSNSRRIRGEVIGFSGDKVLVMPYEPVFGLRKGDKVLLKNELVSTKTGNGVVGKVVDPFGNPLDGGFIGFVEEKGLELPQINPLYRERIREVFDTGVRSVNALFTLGKGQKIGIFAGAGVGKSTLLGMITRHSKADVVVLALIGERGREVKEFLEEVLGEEGLKKSVVVVSTADQSPILKVKGAISAVVHAHHFASQGKDVLLLMDSITRLALAQREIGLAAGEPPTLKGFTPSVFQLLTRIAESCGAFKKGSITGIFTVLVEGDDI...
Function: Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. Catalytic Activity: ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate Sequence Mass (Da): 48507 Sequence Length: 443 Subcellular Location: Cytoplasm EC: ...
Q10F03
MLPLLLPLPVTPPPPLPSPTLTLAPASAPRRRLVLLAAAAPHHHHHHRRRRVYRRQRAAPTQTRAPRRTLSASNAARGEEDLEEAIYEFMRRSDKPGAFPTRAELVAAGRADLAAAVDACGGWLSLGWSSGGAEAGRASSSVGVHPDYPPEAGAAAAAGGASDLAQGAVWASSREAEASPSGRQPETEEEETETKFGTGLDGMLTRLQRERERVRPPLPRSSDGAGGERDNVALMGQSGAPSHSATGGRYTPKVPDNGNIHSYHPQNGALEHNKSSKSLTNDAWRTWSLDKGGFSDFQAAEIHSTNSRKSFRHDGLDILA...
Function: Involved in compound starch granule formation and starch synthesis in endosperm. May act as a regulatory scaffolding protein and affect starch synthesis and compound starch granule formation through direct interaction with isoamylase 1 (ISA1). Binds starch, amylopectin and amylose through its C-terminal carbo...
Q7UQJ2
MAMIDLTHDWQLLAQNPAGGLNSSSLLLLVGVFLALFFAAVLGFFFLRYGKLWFQAFMSDADVQLLNLIRMHFTKVNPNVIVQAKVMVAQAGLNIGRRDGISTHRLEAHYLAGGNVMNVIHAIIAAHRAQIPLEFDQAAAIDLAGRDVLDAVQTSVYPKVIDCPDPKRSGKTTLSAITKNGVELRVRTRVTVRTNIEQLIGGATEDTVIARVGEAIISSIGSAETHFKVLENPDMITRVVLSRGLDAQTAFEIVSIDIADIDVGENIGARLQNDQAEADTRVARAQAERRRAEAIAAEQQMNARVSENRSRLVLAEADVP...
Function: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity. Location Topology: Single-pass membrane protein Sequence Mass (Da): 37257 Seque...
Q7UQD2
MRRPMIASLLLDTLPLAQMPKVTTALLIGALVIFAGIVVVLFIFTSYFGLWIQSVLTGSKISFGNLIGMTFRKVNTRAIVRSKIMATQAGLDDPELTVGALEAHYLAGGNVQQVIRALIAAKKAKTISLTFREATAIDLAGRDVLESVQTSVYPKVIDCPPRGSAKPSLDAVAKDGIQLKVRARVTVRANLQQLIGGATEETIIARVGEGIVSAIGSADDHKAVLENPDVISKAVLVKKLDSQTAFEIVSIDIADIDVGANIGARLQADQAEADTAVARANAEGRRAAAVAEEQEMQAEIAKSQAQVVEAQSDVPRAMAE...
Function: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity. Location Topology: Single-pass membrane protein Sequence Mass (Da): 38691 Seque...
Q5WHE8
MNDSTIFVLIAIALAIILIAILFTFVPVALWISAIAAGVKIGIFELVGMRLRRVVPARVVNPLIKAVKAGLDLDTSRLEGHYLAGGNVDRVVNALIAAQRANIDLSFERAAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANIDRLVGGAGEDTVIARVGEGIVSTIGSQNDHKKVLENPDMISQTVLSKGLDSGTAFEILSIDIADIDIGKNIGAELQTDQAQADKNIAQAKAEERRAMAVAKEQEMKARVEEMRAKVVEAEAEVPMALSEALRQGHMGVMDYMNYQNVMADTDMRDSISKA...
Function: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity. Location Topology: Single-pass membrane protein Sequence Mass (Da): 36663 Seque...
B3ETU2
MTYLYDNSTLWIPILLGFLLFLYFFPVNLWITALFSGVRVSLFELVFMRIRRVPPRVIVESMITATKAGLQVTTTEIETHYLAGGNVPSVIRALISADKANIKLTFKQATAIDLAGRDVFQAVQISVNPKVINTPSVAAVAADGIQLVTKARVTVRANIQQLVGGAGEDTILARVGEGIVTSIGSAASHKEVLANPDQISKLVLQRGLDAGTAFEILSIDIADVDVGENIGAKLQIDQANADLRVAEAKAEERRAMAVAVEQEMRAKSQEARAQVILAESEIPKAMSAALKSGHIGVMDYYRMQNIKADTNMRAAISGEG...
Function: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity. Location Topology: Single-pass membrane protein Sequence Mass (Da): 35915 Seque...
Q6FRT5
MYIGAFQDTLFVDMLEYFGWVTVGKEYLDIYRPNGVPVAPNAVAASISGKEEMKQDNQTSTDSMSTSTQQETDASNEDIERAMDTDNGLDKAMSGGQGVFGTEEDDSSTKDASKPEEADPFLVEFLGEDDPRKPWNWSFSKKTFVIVQLMVLTCINYMGSSIYTPGQEQIQHEFHVGHVVGTLNLSMYVLGYAIGPIIFSPLSEVSSIGRMPLYLWTFILFTILQVACALVRNIAGLVILRFITGILCSPVLATGGASVGDVCFPRYVPRFLGAWAVGAVAAPVMAPILGAAMVVAKDWRWIFWLMLFMCGATLLSIIFF...
Function: Multidrug transporter that confers resistance to 5-flucytosine (5-FC) and clotrimazole . Further confers azole drug resistance . Plays direct roles in extrusion of 5-flucytosine and clotrimazole . Location Topology: Multi-pass membrane protein Sequence Mass (Da): 65989 Sequence Length: 589 Subcellular Locatio...
Q9NLA1
MPINYNRNAVELKLSSQLLQWLDQRLPLGDPMRIPSIDSYKYIQDLGKGRFGTVCKFSNGNTFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLVKETLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYAKSEDGKVLPYTSEVLVPSSSNCVQKIVDLVFIKSPEHRPNT...
Function: Probable serine-threonine protein kinase involved in the control of defecation rhythms. Required to increase the length of defecation cycle period. Acts in a cell-functional rather than developmental aspect in the regulation of defecation rhythms. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-p...
Q6RKD8
MDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAA...
Function: Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases . Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length . May play a role in cell-cell adhesion and ce...
Q8BLU0
MGLQTTKWPGRGAFILKFWLIISLGLYLQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKW...
Function: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells . May play a role in the migration of cortical neurons during brain development via its inter...
Q9NZU0
MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWL...
Function: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion v...
Q8BGT1
MISPAWSLFLIGTKIGLFFQVAPLSVVAKSCPSVCRCDAGFIYCNDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWL...
Function: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners . Plays a role in the spatial organization of brain neurons . Plays a role in vascular development in the retina . Plays a role in cell-cell adhesion via its intera...
Q8GVE3
MDTKHQDKPSILMLPWLAHGHIAPHLELAKKLSQKNFHIYFCSTPNNLQSFGRNVEKNFSSSIQLIELQLPNTFPELPSQNQTTKNLPPHLIYTLVGAFEDAKPAFCNILETLKPTLVMYDLFQPWAAEAAYQYDIAAILFLPLSAVACSFLLHNIVNPSLKYPFFESDYQDRESKNINYFLHLTANGTLNKDRFLKAFELSCKFVFIKTSREIESKYLDYFPSLMGNEIIPVGPLIQEPTFKEDDTKIMDWLSQKEPRSVVYASFGSEYFPSKDEIHEIASGLLLSEVNFIWAFRLHPDEKMTIEEALPQGFAEEIERN...
Function: Involved in the production of the bitter neohesperidosides in citrus. Shows a strict specificity for UDP-rhamnose as donor. Catalytic Activity: flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP Location Topology: Single-pass membrane ...
Q96330
MEVERVQDISSSSLLTEAIPLEFIRSEKEQPAITTFRGPTPAIPVVDLSDPDEESVRRAVVKASEEWGLFQVVNHGIPTELIRRLQDVGRKFFELPSSEKESVAKPEDSKDIEGYGTKLQKDPEGKKAWVDHLFHRIWPPSCVNYRFWPKNPPEYREVNEEYAVHVKKLSETLLGILSDGLGLKRDALKEGLGGEMAEYMMKINYYPPCPRPDLALGVPAHTDLSGITLLVPNEVPGLQVFKDDHWFDAEYIPSAVIVHIGDQILRLSNGRYKNVLHRTTVDKEKTRMSWPVFLEPPREKIVGPLPELTGDDNPPKFKPF...
Cofactor: Binds 1 ascorbate molecule per subunit. Function: Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of na...
Q31HL0
MQSFHVLQLIAVGFGGALGAMARFIVSNQVYAWWGRDFAWGTLVVNSLGSFAIGLIMILMIDKFHASVEMRSFLIVGFLGAFTTFSTFSFETYSFLQTGEITKAMLNIGVSVLTGLFAVWLGIWTGKQFFSP
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14554 Sequence Length: 132 Subcellular Location: Cell inner membrane
B4U812
MNYLAVLVGGGVGALVRYLVSIFIQKFVPNFPLGTMVINTTGAFLIGFLSIYLTEVIDAPPNIRLLLITGFLGGYTTFSTFTLEGIGLINNGDYLKAFYYIVGTNVIGFLFVALGRFLGGLL
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13155 Sequence Length: 122 Subcellular Location: Cell inner membrane
Q0C3G9
MNGFLLVALGGAIGASLRHGVGLVAVRHLPLGWPWGTSFVNIAGSLAMGLLAGWLALKAEGASQEARLFLATGVLGGFTTFSAFSLEVATMLRSGETLKAGLYAGVSVLLGVSALFIGLWMARRIFA
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13092 Sequence Length: 127 Subcellular Location: Cell inner membrane
Q5R0A9
MNNLLLHFFCVAVGGAIGASARFAMVLAMQSFGVRAFPFATLTVNIIGSFFLGLLLAYAEQQPVSETTRLFLGVGLLGAFTTFSTFSVEVVALASQGELLKAALHIAFNVIICIAAVFAAMMLYSTTVK
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13662 Sequence Length: 129 Subcellular Location: Cell inner membrane
A8AAZ9
MKALVWVAVGGALGAIVRYFFYKFVPQVYDFPLATFLVNVVASFLLGFIIGAFEAKPWGQQLKLALATGFCGALSTFSTFAADNYILLRSSKYITAFVYTAVSVGLGIVSVALGEDLAQRLLK
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13286 Sequence Length: 123 Subcellular Location: Cell inner membrane
Q28US2
MLRVFGHGTVGGAFPLPILTVNVLGSFLMGVFVVAAAHRGLTHLSPLVMTGLLGGFTTFSAFSLETVTLYERGDVGQAALYVALSVGLSIAGLMAGLWLARGVFA
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 10825 Sequence Length: 105 Subcellular Location: Cell inner membrane
Q1INF0
MAIREYLWVSLGGIVGACARYFLSRFTAKITGTSFPWGTLLINITGSFVLGLFLVYTTERVFVDPKWRLLIAIGFCGAYTTFSSYAYESMVYFQQGNWGLFAGNVLANNILCLAAVLGAGALVRSI
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13815 Sequence Length: 126 Subcellular Location: Cell inner membrane
Q5ZY60
MVVAPYLAVAIGGSLGAMSRYLVTIMAQNAWGIKFPYGTLLVNTLGSFLAGFFLIVLVGRFSAEESFRLFLFTGFLGAFTTFSSFAAESLFMFEQGYWFKLMTNILVNNVGSLSMVFIGTLVAKYVLLGHQGSN
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14612 Sequence Length: 134 Subcellular Location: Cell inner membrane
Q8EZS4
MNFSKSLLLIAFGGTIGSIFRYLLQYWFGNVLGYSLPWGTLTANLLGSFLIGVVYAISDRFPLFDPQWKFLLASGFCGGFTTFSTFSYETFQMLKSGHYILFLGYICLSVVGGIGFAFAGVWMIKNF
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14173 Sequence Length: 127 Subcellular Location: Cell inner membrane
A0L889
MQIAWVALGGAIGAVARYVLSNAVYAWLGRAFPWGTLSVNLLGSFIMGLLFYLFTQRLMVPEALKPLVLVGGLGAFTTFSTFSLETLNLMQSGSWSLALLNMLSSVLLCVLAAYLGLVVGRLI
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13189 Sequence Length: 123 Subcellular Location: Cell inner membrane
Q2W1R5
MLTYALVALGSAIGGTLRYWLSMVIAEASAGTFPWATLVINVAGSAAIGLFATLTSVDGRVFVPSEWRTFFMVGICGGFTTFSSFSLQTLALAQDGDWLAAGLNVVGSVALCLLAVWLGHVAATIINR
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13348 Sequence Length: 128 Subcellular Location: Cell inner membrane
Q65QC7
MIMWQSLILISSGAALGASLRWGMGLILNPLFAAFSFGTLIANYLGCFIIGLIMAMIWQHPQFSGEWRLFMITGFLGSLTTFSSFSAEVMENFIQQKWLIGLGIMSAHLFGCLIFTGIGVLITRWLN
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14089 Sequence Length: 127 Subcellular Location: Cell inner membrane
A1U6R3
MWWSVLAVSVGAVIGANLRWGLGLWLNASYHAVPWGTLVANLSGGWLIGVLMAFFSQSSVLSPEWRLFAVTGLCGALTTFSTFSLEMFAALQEGKWGMALVGILAHVVGSILMTALGFLTFSLVRG
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13437 Sequence Length: 126 Subcellular Location: Cell inner membrane
C6BTV9
MHKYLYIAAGGAAGSLCRYLVSGVTQRMFATSFPIGTFSVNMIGCLFFGLVTGLFEERLGLPPEMRLLILTGFMGAFTTFSTYMFESTNLIKSGQWAMTALNIGGQSILGFACIVGGLALGRLIVS
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13482 Sequence Length: 126 Subcellular Location: Cell inner membrane
Q87KE9
MGQFSILGFIALGGAIGACSRYLVSEFCVLLFGRGFPYGTLTVNVVGSFIMGLLIAAFENEILATEPWRQVIGLGFLGALTTFSTFSMDNVLLMQQGAFFKMGLNILLNVVLSISAAWIGFQLLMRS
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13714 Sequence Length: 127 Subcellular Location: Cell inner membrane
Q3BTX1
MNAPVWWQQLLLAMTGGALGSGLRFAIGASLIQRFGTGFPWGTLTVNLLGSFVAGVLLVWLDARGPSSWPLRALLIVGVIGGLTTFSSLMMECLVFARTDRSTMIGIYLAVTLLAGLALVVAGARTGQWLVAR
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14064 Sequence Length: 133 Subcellular Location: Cell inner membrane
Q5GZS7
MRIATSYEMCAQCCCAAAKFADTLQTKPRRSHVTPIYTIAAISLGASLGALARYGLGLALNAIFPPLPIGTLAANLIAAYVVGVTIAYVGTVPGLSPLWRLFMITGLAGGLSTFSTFTAELFSLLREGRLGMSAGMLGLHVGGSLALLMLGMLTIGLLRKSSLGIAE
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 17294 Sequence Length: 167 Subcellular Location: Cell inner membrane
Q9PDC5
MNAVVWWQSLLLVMLGGAFGSGLRFVIGSCLLQRFGAGFPWGTLAVNLIGSFVAGFLLIWLDKRGSAGWSWRMLLIVGLIGGLTTFSSLMMECLVFVRSDRSLMVGLYLCITLLFGLLFVFLGARLGAFVCDDQRVLEIDRTA
Function: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Catalytic Activity: fluoride(in) = fluoride(out) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 15691 Sequence Length: 143 Subcellular Location: Cell inner membrane
F8JX40
MTVHQAPGTPGSVISLRPRYDNWIGGDWKAPAEGRYFANPTPVTGEEYTEIARSTAADIDLALDAAHAAAPAWGRTAPAERAAVLGRIADRIEQHLTELAVAEVWDNGKPIREALAADLPLAVDHFRYFAGVLRAQEGSISQLDEDTVAYHFHEPLGVVGQIIPWNFPLLMAVWKLAPALAAGNAVVLKPAEQTPVSILVLMELIADILPPGVINVVNGFGIEAGKPLAINPRIAKVAFTGETTTGRLIMQYASQNLIPVTLELGGKSPNLFFEDVAAARDDFYDKALEGFTMFALNQGEVCTCPSRALIAGGIYDGFLG...
Function: Catalyzes the oxidation of fluoroacetaldehyde to fluoroacetate. Has high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde. Catalytic Activity: fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH Sequence Mass (Da): 54570 Sequence Length: 507 EC: 1.2.1.69
Q940U6
MAALIRCCSSFSHTSGGQPPPRDKSRAPEIGKFATSIGYSVVRKPGDHPPFSKIIHSSSQPKERQGKGILQTPFASVGSLDKFSAFEGIGRLKLPVMAVLLTNSLQMATPLEALAAEICEPESSMFSMPILLLVALIGATVGGLLARQRKGELQRLNEQLRQINAALRRQAKIESYAPSLSYAPVGARIPDSEIIVEPKKQELISKLKTGKTFLRNQEPEKAYTEFKIALELAQSLKDPTEEKKAARGLGASLQRQGKYREAIQYHSMVLAISKRESEDSGITEAYGAIADCYTELGDLEKAGKFYDTYIARLETD
Function: Negative regulator of tetrapyrrole biosynthesis (including chlorophyll) in chloroplasts, probably via HEMA1 repression. Inhibits especially the magnesium ion Mg(2+) branch of tetrapyrrole biosynthesis, but independently of heme. Location Topology: Single-pass membrane protein Sequence Mass (Da): 34587 Sequenc...
B8NHD7
MRYLITGATGGLGGHILEYFIAQIPFSDFAASSSSPENRSRFESRGVNFRHLDYENPTTLNRALHDVENLLFISTNANVIDVEKVKRQHRNVVEAARKANVKHVWYTSLPFGGLTNDSEVSVQRAHLATEKMLKESGLTFTCIREGIYVEGFPLFLNWYPETTLLTLPRDGEIAFTSRVELAVCTARLMIQGGFENRIVLLTAGETITAKELVSVINETTGRRVELRYVSPDEFVDAGPRNDRGGKSRAFFETLVSLWESAASGELRTMDGLMAEILGRDPIPPRDAVRQLLVENRDHTWHQMYAKK
Function: NmrA-like family domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of flavunoidine, an alkaloidal terpenoid with a tetracyclic cage-like core connected to dimethylcadaverine via a C-N bond and acylated with 5,5-dimethyl-L-pipecolate . The tetracyclic core is synthesized...
Q9N1F2
MVKLNDEEGAAMAPGHQPTNGYLLVPGGEPPGKVSAELQNGPKAVCLTLNGVSRDSLAAAAEALCRPQTPLAPEEETQTRLLPTGPGEETPGTEGSPAPQTALSARRFVVLLIFSLYSLVNAFQWIQYSVISNVFEGFYGVSSLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWVKCASVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGAAIGFLLPPVLVPNTQNNTDLLACNISTMFYGTSSVATFLCFLTIIAFKEKPQYPPSQAQAALQNSPPAKYS...
Function: Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in...
Q4WLW7
MKLPAAAGDAIVIGPNAVRLIKSWGEQLCEEIEPHLSNATHAEMLDHHDRFIVRHELAGRGKGWFTNRGRLISILYEHARKLGIDIRLGSRVTKYWEEDGRAGVIVNDRERLAADCVICADGVHSAARAWLTGQVDTQQHSGWANFRAHMTTEQLAKDPEASWVLQGTREKDRVYVWFGDGINLAIMTMKRGQELAWALMHTDKFNAHESWAGGRASIDDALATLSPWPGRLRPSSVIRHTLPEKLVDHALIYRPPLDTWVSAGGRVMLIGDAAHPYFPVVGQGGSQAIEDGVVVATALELAGKENVPLALRIRATLTEE...
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antitumor fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts . The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from ...
Q4WLW6
MQYIPFLISGLVPVALSKSLFEATSNTRIDGNDIAAIFGPVLTPEAHIFLPSDGDYDDNVMARWSTFNDPSYVATVKPATETDVQAIREYQVSTAASHNITFFATGGGHGVKLNFGNVQNAINIELSLLDFIDLDLDNEVVTIGPGVENAQLYDLLSSVGKETALTGERCVNTIGPTLGGGLGPLYGIRGPQVDSLVSARLVTASGDVITVSRSENRDLFWAIRGAGANFGIVTSATYRIYDQTNGGMAVSAQFAFAPAVNRSVFDLMESMNDEYPPGMSGGMILSYNHTTNEPSVQWNLLFMGSNEDAQPWLDKIQALG...
Function: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the antitumor fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts . The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from an...
Q4WLW9
MPEDKVEAIEHVESSRHDATVNEKAIADFLNAEKEMTTWQAVRAHRRLLLFAAYRVTHLAILPFVCASNYGYDTVSNGSSIAMPAFIMSFGAMNHATGSMYLPSIWTSLWTSMTNLGQALGSLIAGFLAERIGRRWTAVSLAILSIVGTFILVFSSTRGMLLVGKTMNGAVVGGLMAIGTTYAADVAPIKLRGALLQAIVFFGVAMQGVSLGIVRAFILDMRPLAWKIVFGIQWAFATLVLIAAFLVPESPVFYVAHGKHDKAQSALRRLHGSSDQYLHIRYGAIVHALDEERKQQSESVSWAELFKGCNLKRTITIGFI...
Function: MFS transporter; part of the gene cluster that mediates the biosynthesis of the antitumor cytotoxic peptidyl alkaloids fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts . Probably involved in fumiquinazolines metabolism and transport . Locati...
Q493I2
MVHSKSLRIAFFGTTSFAAWHLHTLAHLSTHQIIAVFTQEIQISTCKSFLSLHKIAKKYNISLFQSRTLSISDIIYIIKKINVDLIVVVSYGLILPQEILNIPRLGCINVHGSLLPRWRGPAPIQRALEYGDSITGITIIQMDLGIDTGDILHIMPCKIFPKDTSCTLSNRLVNIGSAMLSQVLDQFILGTFTLIPQDSTYATYAHKLNKQEARINWNLSAIQLERCIRAFNPWPISFFQIKNDRIRVWDAEVSNQNINNYSSSTSILPGTILAAHPNGIYVVTGSGILILTMLQISGKKITSVRDLLNAYKEWFKPNSV...
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Catalytic Activity: (6S)-1...
Q2L0K7
MRLVFAGTPEFARLALEALLAAGHEIPLVLTQPDRPAGRGLKLTPSPVKEAALAAGIEVAQPRSLRLDGRYPDEALAAQARLVAVAPEVMVVAAYGLILPRWTLALPARGCLNIHASLLPRWRGAAPIQRAIEAGDARTGVTIMQMDDGLDTGDMLLERTVPIGAETTAAVLHDELARVGAEAIVAALADLPALAPRKQPEQGVTYAAKLDKAEAALKLDESAELLARRIRAFNPVPGASLRLPGLNEPVKVWQAEALPESSPAAPGTVLRASAQGVDIATGQGVLRLLELQKAGGKRQSAEVFVRGWQPA
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Catalytic Activity: (6S)-1...
O51091
MKIFFVSSSSIALEVFKEIVKHYEVVGVLTLPDRPKGRGQKLSQNVIKSEAIARNIKVLDPLILDDNVLNLVRDLNPDLMLVFSYGKIFKKEFLDLFPKGCINVHPSLLPKYRGVSPIQSAILNGDCVSGVTIQSMALEMDSGNILVQKNFKIRSYDTSHDISKLVSSLSPSLVLEALEKISKGFLGIPQKSSEATFCSFLKKESGFIDFNLSAFEIKNKINACNPWPLVRVRLDYNDIIFHRADFLEVDLYKERKIGEIVDFNPEKGLFVNTGKGILLLLEVQRPGRKVLDFKSFYNGSRQLIGQVFSSIE
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Catalytic Activity: (6S)-1...
Q89BP0
MPLRLIFMGTPDFSVPTLLELVAHGHEIVAVYTRAPKPGGRRGLQLQPTPVEEAARRLGVPVLTPKTLKTEEALEEFRAFDADAAVVVAYGMILPQAILDAPKLGCYNLHASLLPRWRGAAPINRAIMADDAESGVMVMKMDVGLDTGDVAMAERLAITDTMTAADLHDRLSRLGADLMVRAMAALDRGGLQLKKQSEDGVTYAAKIDKAEARIDWTKPARAVLRHIHGLSPFPGAWAELAGVSENARVKILRCELAKGSGAPGEVLDDQLTIACGEGAIRIIELQREGKARMQATDFLRGVPLKAGAKFT
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Catalytic Activity: (6S)-1...
Q8RDM3
MKIIFMGTPTFAVPSLEKIYKEHEIISVFTKVDKPNARGKKINYSPIKEFALANNLKIYQPENFKDNTLIEEIRNMQADLIVVVAYGKILPKEVIDIPKYGVINLHSSLLPRFRGAAPINAAIINGDTKSGISIMYVEEELDAGDVILQEETEISDEDTFLSLHDRLKDMGADLLLKAIELIKKGEVKAQKQDKKLVTFVKPFRKEDCKIDWTKTSREIFNFIRGMNPIPTAFSNLNGTIIKIYETKINDKVYNNATCGEVVEYLKGKGIVVKTSDGSLIISSAKPENKKQMSGVDLINGKFLKIGEKLC
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Catalytic Activity: (6S)-1...
Q74GW4
MAGLRIIFMGTPEFACPTLRKLIERGEEVIAVVTQPDRPKGRGQKLVPPPVKALAQEHDIPVLQPLKVRTPESVDEIRRLAPDLIVVVAFGQILPQSLLDIPKHGCINIHASLLPRYRGAAPLNWCLINGETETGITTMMMDAGLDTGDMLVKRAIPIGPDEDAQSLHDRLSQLGAETIDETLDLLLAGKLVREKQDDSLTCYAPMLKKEDGLVDWTREPVQVKNQVRGFTPWPGAYTFLDGKTLKLYRVAVAGETGEPGEILRVGREGILVGCGSGSILIQELQLEGRKRLPTAEFLAGFRLEPGTRLGEAGSVEH
Function: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Catalytic Activity: (6S)-1...