ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
O23920
MGKKQSEAEILSSNSSNTSPATFKLVGFNNFVRANPKSDHFAVKRFHHIEFWCGDATNTSRRFSWGLGMPLVAKSDLSTGNSVHASYLVRSANLSFVFTAPYSPSTTTSSGSAAIPSFSASGFHSFAAKHGLAVRAIALEVADVAAAFEASVARGARPASAPVELDDQAWLAEVELYGDVVLRFVSFGREEGLFLPGFEAVEGTASFPDLDYGIRRLDHAVGNVTELGPVVEYIKGFTGFHEFAEFTAEDVGTLESGLNSVVLANNEEMVLLPLNEPVYGTKRKSQIQTYLEHNEGAGVQHLALVSEDIFRTLREMRKRS...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 48148 Sequence Length: 442 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. Subcellular Location: Cytoplasm EC: 1...
Q76NV5
MEGFDHVTFWVGNALQAATYYIARFGFQNLAYSGLETGNRQFATHVIHQNNIIMAFTSPLTGDNKDYADHMMRHGDGVKDIAFNVKDVQHIYDEAVKAGAQSVKEPHQIKDEHGIVTLATIMSPYGETTHTFVDRSQYKGAFLPGFTYKVASDPLSNITEPVGLNLIDHVVSNHADKMMEPVVQWYEKVLQFHRFWSVDDKTIHTEYSSLRSVVVADKSEKVKLPINEPANGIRKSQIQEYVDFYNGAGVQHIALKTDNIIDAISKLRSRGVSFLTVPKTYYTSLREKLQHSSLEIKEDLDTLEKLHILIDYDDKGYLLQ...
Cofactor: Binds 1 Fe cation per subunit. Function: Key enzyme in the degradation of tyrosine. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 41738 Sequence Length: 367 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylala...
O48604
MPPTPTTPAATGAAAAVTPEHARPHRMVRFNPRSDRFHTLSFHHVEFWCADAASAAGRFAFALGAPLAARSDLSTGNSAHASQLLRSGSLAFLFTAPYANGCDAATASLPSFSADAARRFSADHGIAVRSVALRVADAAEAFRASRRRGARPAFAPVDLGRGFAFAEVELYGDVVLRFVSHPDGTDVPFLPGFEGVTNPDAVDYGLTRFDHVVGNVPELAPAAAYIAGFTGFHEFAEFTAEDVGTTESGLNSVVLANNSEGVLLPLNEPVHGTKRRSQIQTFLEHHGGPGVQHIAVASSDVLRTLRKMRARSAMGGFDFL...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 46550 Sequence Length: 434 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. Subcellular Location: Cytoplasm EC: 1...
P32754
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEEL...
Cofactor: Binds 1 Fe cation per subunit. Function: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Location Topology: Peripheral membrane protein Sequence Mass (Da): 44934 Se...
Q96X22
MSPSAITESPRNSVVDHTSGLQVDSLAVQGPFPSFHGYDHVTWWVGNAKQAASYYNTLFGMKIIAYRGLETGSRYFASYLVGKEDVRFVFTSPIRSHVHLPEDEPISDEDRALLKEMHAHLEKHGDAVKDVCFEVDNVQGVYERAVQQGAVSIAPPKTLSDKEHGSVTMAVIQTYGDTTHTLLSRDNFRGTFLPGFRDVNRQPAAYSALAPVPLQRIDHCVGNQDWDDMRAACDFYERCLSFHRFWSVDDNQISTDFSALNSIVMASPNNVVKMPINEPAKGKKRSQIEEYVTFNSGAGVQHIALLTSDIITTVEAMRSR...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 47576 Sequence Length: 419 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. EC: 1.13.11.27
Q872T7
MSPSAISSEYSNCNGTPDYALQSSEVSNFNGYDHVTWWVGNAKQAASYYNTVFGFKTLAYRGLETGSRYFASYVVGNADVRFVFTSPIRSQKCLPEEEPISDADRKLLQECHEHLEKHGDAVKDVAFEVDNVDGVFHKAVAAGADVVQEPTTLTDKMHGSVRTAVIRTYGDTTHTLISRADYNGPFLPGFRTAAPSSATVQLPSVPLARIDHCVGNQDWNEMVSACAFYEQCLSFHRFWSVDDSQICTEFSALNSIVMASENNLVKMPINEPAPGKKKSQIEEYVVFNSGAGVQHIALLTPDIISTVSAMRARGVEFINV...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 46029 Sequence Length: 412 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. EC: 1.13.11.27
Q02110
MTSYSDKGEKPERGRFLHFHSVTFWVGNAKQAASYYCSKIGFEPLAYKGLETGSREVVSHVVKQDKIVFVFSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAIIVREEVCCAADVRGHHTPLDRARQVWEGTLVEKMTFCLDSRPQPSQTLLHRLLLSKLPKCGLEIIDHIVGNQPDQEMESASQWYMRNLQFHRFWSVDDTQIHTEYSALRSVVMANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRSLRERGVEFLAVPFTYYKQLQEKLKSAKIRVKESIDVLEEL...
Cofactor: Binds 1 Fe cation per subunit. Function: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Location Topology: Peripheral membrane protein Sequence Mass (Da): 45064 Se...
Q9ARF9
MGQESTAAAAVVPAEFKLVGHKNFVRSNPMSDHFPVHRFHHVEFWCGDATNTSRRFSWGLGMPLVAKSDLSTGNSAHASYLLRSGELSFVFTAPYSPSLAEPSSASIPTFSFSDHRAFTSSHGLAVRAVAIQVDSASSAYSAAVSRGAKPVSPPVVLADCETAIAEVHLYGDTVLRFVSCGSGADGWFLPGFEVVGDGVSCQELDYGIRRLDHAVGNVPKLEPVVDYLKKFTGFHEFAEFTAEDVGTAESGLNSVVLANNNENVLFPLNEPVYGTKRKSQIQTYLDHNEGAGVQHLALITEDIFRTLREMRKRSEVGGFE...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 47736 Sequence Length: 436 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. Subcellular Location: Cytoplasm EC: 1...
Q9I576
MNAVAKIEQHNPIGTDGFEFVEFTAPDAKGIEQLRQLFNMMGFTETAKHRSKEVFLFQQNDINIVLNGSPTGHVHEFALKHGPSACAMAFRVKNASQAAAYAESQGAKLVGSHANFGELNIPSLEGIGGSLLYLVDRYGDRSIYDVDFEFIEGRSANDNSVGLTYIDHLTHNVKRGQMDVWSGFYERIANFREIRYFDIEGKLTGLFSRAMTAPCGKIRIPINESADDTSQIEEFIREYHGEGIQHIALTTDDIYATVRKLRDNGVKFMSTPDTYYEKVDTRVAGHGEPLEQLRELNLLIDGAPGDDGILLQIFTDTVIG...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 39913 Sequence Length: 357 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. EC: 1.13.11.27
P80064
ADLYENPMGLMGFEFIELASPTPNTLEPIFEIMGFTKVATHRSKDVHLYRQGAINLILNNEPHSVASYFAAEHGPSVCGMAFRVKDSQKAYKRALELGAQPIHIETGPMELNLPAIKGIGGAPLYLIDRFGEGSSIYDIDFVFLEGVDRHPVGAGLKIIDHLTHNVYRGRMAYWANFYEKLFNFREIRYFDIKGEYTGLTSKAMTAPDGMIRIPLNEESSKGAGQIEEFLMQFNGEGIQHVAFLSDDLIKTWDHLKSIGMRFMTAPPDTYYEMLEGRLPNHGEPVGELQARGILLDGSSESGDKRLLLQIFSETLMGPVF...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 40061 Sequence Length: 357 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. EC: 1.13.11.27
C0CMQ8
MKIVVLDGYCLNPGDLDWKGLEALGECIVYDRTSLTDMEEVISRIGDADIVYTNKTPMPREVFEKCPNIRFVGVLATGYNVVDVNTAKEKGIPVANIPTYGTASVGQFAIALLLEICHHVGHHNQVVHEGKWESNPDWCFWDYPLIELDGKNMGIIGYGRIGQATGKIAQALGMKVLAYDAYKNPALENENCRYVELDELLSQSDVIALHCPLFPETEGIVNKENIAKMKDGVIILNNSRGPLIVEQDLVDALNSGKVAAAGLDVVSTEPIKGDNPLLGAKNCIITPHISWAPKESRKRLMDIAVNNLEEFLKGSPVNVV...
Function: Involved in catabolism of D-apiose. Catalyzes the reduction of 3-hydroxypyruvate to glycerate. Catalytic Activity: (R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH Sequence Mass (Da): 35325 Sequence Length: 322 Pathway: Carbohydrate metabolism. EC: 1.1.1.81
Q9X1C1
MARYRVHVNDPLDKEATQLLMNKEELEVTSEHLEKDELMKIIPEVDVLVVRSATKVTADIIEAGKNLKIIARAGIGLDNIDVQKAKEKGIKVLNTPGASAPSVAELAMGLMLACARHIARATVSLKEGKWEKKALKGKELLGKTLGLIGFGNIGQEVAKRALAFGMKIIAYDPAKPETDLPVEYVDLDTLFKESDFISLHVPLTESTRHIINRESIAKMKDGVIIVNTARGGTIDEEALYEEVVSGKVYAAGLDVFEVEPPTDEIRRKLLSLDNVVATPHIGASTAEAQRRVGIELVEKIFKELGI
Function: Involved in the degradation of L-serine via 3-hydroxypyruvate. Catalyzes the non-reversible reduction of 3-hydroxypyruvate to yield D-glycerate. Catalytic Activity: (R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH Sequence Mass (Da): 33451 Sequence Length: 306 EC: 1.1.1.81
Q52473
MVAFAGLTSKLTNLGNSAVGGVGGALQGVNTVASNATLQKNILLGTGDSLSVDAQAKASKESDANGAKLIAMQAQETMKKQTMDVLNAIQAGKEDSTNKKISATATNAKGISY
Function: Major structural protein of the Hrp pilus, which is a component of the type III secretion system (T3SS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. Required for secretion of virulence proteins such as HrpW and AvrPto. The Hrp pilus functions as a conduit for pr...
P35654
MSSLFVWLNRLAISAMQRSEVVGAAIVMSIVFMMIIPLPTGLIDVLIALNICISSLLIVLAMYLPKPLAFSTFPSVLLLTTMFRLALSISTTRQILLQQDAGHIVEAFGNFVVGGNLAVGLVIFLILTVVNFLVITKGSERVAEVAARFTLDAMPGKQMSIDSDLRAGLIEAHQARQRRENLAKESQLFGAMDGAMKFVKGDAIAGLVIVFINMIGGFAIGVLQNGMEAGAAMHIYSVLTIGDGLIAQIPALLISLTAGMIITRVSADGQQVDANIGREIAEQLTSQPKAWIMSAAGMLGFALLPGMPTAVFVIISAIAL...
Function: Involved in the secretion of harpin; a proteinaceous elicitor of the hypersensitivity response in plants. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 79505 Sequence Length: 715 Subcellular Location: Cell inner membrane
O14792
MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan . Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) . This modification is a crucial step in the biosynthesis of anticoa...
O35310
MTLLLLGAVLLVAQPQLVHSHPAAPGPGLKQQELLRKVIILPEDTGEGTASNGSTQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSQGLGWYLTQMPFSSPHQLTVEKTPAYFTSPKVPERIHSMNPTIRLLLILRDPSERVLSDYTQVLYNHLQKHKPYPPIEDLLMRDGRLNLDYKALNRSLYHAHMLNWLRFFPLGHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGKDRCLHESKGRAHPQVDPKLLDKLHEYFHEPNKKFFKLVGRTFDWH
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan . Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) . This modification is a crucial step in the biosynthesis of anticoa...
Q9Y278
MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDDLGRSRLLGAPRCLRGPSAGGQKLLQKSRPCDPSGPTPSEPSAPSAPAAAVPAPRLSGSNHSGSPKLGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDWYRSLMPRTLESQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRNRTLGLVDVSWNAIRIGMYVLHLESWLQYFPLAQIHFVSGERLITDPAGEMGRVQDFLGIKRFITDKHFYFNKTKGFPCLKKTESS...
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate . Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS . Unlike HS3ST1/3-OST-1, does not convert non-...
Q673U1
MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDGLGQSRLLGAPRCLRGPSASGQKLLAKSRPCDPPGPTPSEPSAPSAPAAAAPAPRLSGSNHSGSPKPGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDWYRSLMPRTLETQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRNRSLGLVDVSWNAIRIGMYALHLESWLRYFPLAQIHFVSGERLITDPAGEMGRIQDFLGIKRFITDKHFYFNKTKGFPCLKKPEST...
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (By similarity). Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS (By similarity). Unlike HS3ST1/...
Q9Y661
MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRT...
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By ...
Q8IZT8
MLFKQQAWLRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRALQFKRGLLHEFRKGNASKEQVRLHDLVQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQEIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLIIVREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCEVNTKYKAVRTSIYTKHLERWLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLRFNIIFNKCLAGSKGRIHPEVDPSV...
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagu...
Q96QI5
MAGSGGLGGGAGGGQGAGAGQGAALRASRAPMLLVALVLGAYCLCALPGRCPPAARAPAPAPAPSEPSSSVHRPGAPGLPLASGPGRRRFPQALIVGVKKGGTRALLEFLRLHPDVRALGSEPHFFDRCYERGLAWYRSLMPRTLDGQITMEKTPSYFVTREAPRRIHAMSPDTKLIVVVRNPVTRAISDYAQTLSKTPGLPSFRALAFRHGLGPVDTAWSAVRIGLYAQHLDHWLRYFPLSHFLFVSGERLVSDPAGEVGRVQDFLGLKRVVTDKHFYFNATKGFPCLKKAQGGSRPRCLGKSKGRPHPRVPQALVRRL...
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-...
Q9Y663
MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGGEEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPA...
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate . Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 . The substrate-sp...
Q8BKN6
MAPSGPTGAQPSPAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCPPGSGPVAGVPGRGVPAGPRELAMWPAGAPRKRLLQLRQRRRRGRSGPGDSSDQEEQSPGLAAAPGGSGAGSSVAEAQPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYHKGLAWYRDLMPRTLEGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPSFESLTFRNRSAGLIDTSWSAIQIGLYAKHLEPWLRHFPLGQMLFVSGERLVSDPAGELRRVQDFLGLK...
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike HS3ST1/3-OS...
A4FUZ6
MLPNTGKLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQAHPKLPGTIYTAAEEIKAAGGKALPCIVDVRDEEQISSAVEKAVEKFGGIDILVNNASAISLTNTLETPTKKVDLMMNVNTRGTYLTSKACIPYLKKSKVAHILNLSPPLNLNPLWFKQHCAYTIAKYGMSMCVLGMAEEFKGEIAVNALWPRTAIHTAAMDMLGGSGVESQCRKVDIMADAAYCIFKKPKSFTGNFIIDENILKEEGIKNFDVYAITPGHPLLPDFFLDEQPAMVTKKADSYGAVPELKEEKTQPPPKARSGAVEETFRIVKDS...
Function: Has apparently no steroid dehydrogenase activity. Sequence Mass (Da): 45150 Sequence Length: 418 Subcellular Location: Peroxisome EC: 1.-.-.-
Q6P5L8
MLQNTGKLAGCTIFITGASRGIGKAIALKAAQDGANVVIAAKTADPHPKLPGTIYTAAAEIEAAGGKALPCIVDVRDEKQINDAVEQAVEKFGGIDILVNNASAINLTGTLQTPMKKADLMLGINLRGTYLTSKLCIPHLLKSKNPHILNLSPPLNLNPIWFKNHTAYTIAKYGMSMCVLGMAEEFRGSIAVNALWPKTAIQTAAMDMLGGSEVGKQCRKVEIMADAAYAIFKQPTSFTGQFVIDEDILKKEGIKDFDVYAVEPGHPLLPDFFLDGQPEDLVKHMEAHGATPAFTTAKADPVAAGPVSEMFNTIRGIISP...
Function: Has apparently no steroid dehydrogenase activity. Sequence Mass (Da): 44421 Sequence Length: 415 Subcellular Location: Peroxisome EC: 1.-.-.-
Q6YN16
MLPNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKSFTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDS...
Function: Has apparently no steroid dehydrogenase activity. Sequence Mass (Da): 45395 Sequence Length: 418 Subcellular Location: Peroxisome EC: 1.-.-.-
Q2TPA8
MLPNTGKLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTTQKHPKLLGTIYTAAEEIEAAGGTALPCVVDVRDEQQINSAVEKAVEKFGGIDILVNNASAISLTNTLDTPTKRVDLMMNVNTRGTYLTSKACIPFLKKSKVGHILNLSPPLNLNPLWFKQHCAYTIAKYGMSMCVLGMAEEFRGEIAVNALWPRTAIHTAAMDMLGGSGVENQCRKVDIIADAAYSIFKRPKSFTGNFIIDENILKEEGIKNFDVYAIAPGHPLLPDFFLDEHPDAVMEEKESNDSVPEVKEEKLQLQEESQLQKQPQLQEQPQLQ...
Function: Has apparently no steroid dehydrogenase activity. Sequence Mass (Da): 54208 Sequence Length: 490 Subcellular Location: Peroxisome EC: 1.-.-.-
Q4V8F9
MLPNTGKLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTTQRHPKLLGTIYTAAEEIEAAGGKALPCVVDVRDEQQINSAVEKAVERFGGIDILVNNASAISLTNTLETPTKRVDLMMSVNTRGTYLTSKACIPFLKKSKVAHILNLSPPLNLNPMWFKQHCAYTIAKYGMSMCVLGMAEEFRGEIAVNALWPRTAIHTAAMDMLGGAGVESQCRKVDIIADAAYSIFKRPKSFTGNFIIDENILKEEGIKDFDIYAITPGHPLLPDFFLDEHPDAVMEEKESYDPVPEVKEEKLQLQEQPQLQEQPQLQEKPQLQ...
Function: Has apparently no steroid dehydrogenase activity. Sequence Mass (Da): 58344 Sequence Length: 524 Subcellular Location: Peroxisome EC: 1.-.-.-
Q3AC32
MSDYLVKGMAGEFIRFTGVSSRQTVEEARKRHNLSRLATAALGRALTATIILASDLKNPGDLLTLRIFGDGPLGGIVCSAGNDGMVRGYLFNPEVELPLNDANKLDVGRGIGKGHLYVTKDLGLKEPYTGTVQLVSGEIAEDVAYYLYYSEQRPNVFNLGVLVNPDGSVAQAGGCLIEILPGAPEEIISTLEQNLGEQQSLTYQLQQGKHIEEIIQEVVNPYKTEIYVKKPVGFLCSCSREKLLPHLIGLYSEVKDEEIVEAVCHFCREKYTFSGKEIKEYKEKNT
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
P58097
MTDIAPDTGVLDDVVSAFQIENLPVRGRVVRLGAAIDEVLTRHDYPEPVANLLGEACALAALVGSSLKFEGRLIVQAQGDGPVRYVVVDYDTSGGLRGYCRFDPEEVAAVSEGFVRPGAKTLLGGGVFIMTLDQGPDMDRYQGVTPIEGETLALCAEQYFAQSEQTPTRVRLAVGQADTGQGATWRAGGILIQVIAGDQARGETQDAWTHVQALFETTGEDELIDPTVSTPTLLWRLFNEDGVRLLDEKPLKAFCRCSEDRIGVVMDSFSAEEVAEMVEPDGKIHVTCEYCSRIYKLDPPGA
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q1QU53
MTDQIQRFLFDETNVRGEIVGLQQAYADVLDKHAYPAAVRRQLGELLGAVALLTETVKLDGTVSLEVRGQGAVRLLMAESNPGGELRAIARLDDEAALPEENASLTALVGEAQIVITLDPRDGQRYQGIVAVEADTLAACLEDYFARSEQLATRLWLAADGDRAAGMLLQQLPDDASNRDPDAWERTVHLATTLSDAELLDLDQRELLYRLFHEEQARVFEPKALRFGCTCTRERIASALHGLGADELRHIVREQGAVETQCHFCHSHYRFTAADIETLIESPGAGAPTLH
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q7NWI9
MNMNHHDKLQRFLFDGAPVRGALVRLDGAWQQVLARRAYPQALKTVLGEMMAASVLMAANLKFDGSLILQIHGTGALKLAVVECNNDRTVRATAKWDGDLDGKPLKALLGEGGKFVLTLEPRLDKNQTWQGIVALEGDSVGQMLENYMLRSEQLDTALVLASGDEAAAGMLLQRLPEGHGEAEGWDRVQMLGRTLKAEELLGLGAEDILHRLFHEEQVRVFEQETVSFNCNCSRERVSNMLTMLGGQEVGDVLLEQGSVEIVCDYCNQRYVFDEEDANQLFDYDVVAAAREARH
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
B5EC90
MTDYLVRAIAKSGSVRALACVTTATVGAICKRHDTLPTATAALGRGITAGALMGALLKTGQRVAMRFEGNGPLKKIVIEADANGSVRGYVGDPKVHLLRPDGALDVNNALGRAGFLTVAKDLGLKEPYRGTVQLYTSGIAEDLALYLVESEQIPSAVGIAEFIEQDGTVAAAGGFLIQAVPPVDPLVIEELMTRIEQLPPLSELLHKGGNPEQILEQLLAGIPYDILEKRNIAFACSCSRERIERVLLSMGKKELSSMKKDQHGSEVTCEFCGEHYLFDEADLDRIIAEIAKQEG
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q17ZW5
MRDYVLRATSGNGQVRAFVATTRNTVEEARRLHETTKVATAALGRTLTATSIMGLMMKNDSDKLTVIIKGGGPIGTIIATSDSKGMVKGYVGNPQVEVEDYPNGKLNVAAAVGTEGVVKVIKDLGLREPYNGTYPLVSGEIAEDFTYYFAVSEQTPSVVALGVLTKEDEVEFAGGFIVQLMPDAEEETIAKLEENVAKLPSITNMLKEGKSPEDILNIVLDGLEPKILDTCEVGFMCECSKERVKTALVAIGKKSLAQIIEEDKKAEVGCQFCNKKYMYSEEELLEILKEM
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q5SJV8
MGRILRGLAGEGDLRVVAAETTDVVEEARLRHGLSPTATAALGRAMTGALLLAQLLLKTPKERITLRVEGTGPLGGLVVEADAFGHVRGYVKNPRAEVPLREDGKLNVGELVGAGALRVDRSLPSGEVYTSTVPLVSGEIAEDLAHYLWQSEQIPSAVLLGVRVKGEGEVEVAGGVAVQVMPGAREEVLDRLEANLKDLPGLTPLLRERGLEGALEALLAGLGFERTDLRALGYFQNEIPARFRCRCNREKALEALVFFTPEEREDMIVKDGGAEVVCHWCGEVYRFSPEEVRSLVAEVRCPDCGTLWLYPKGDGTLARI...
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
B5YJH3
MDEVVKGLIKNEHVLVVATICTETVEYARKIHDTWPTATAAMGRVIAGSVLLASTLKDRQKIMVQIKGDGPLNEVVAEADSFYRVRAYVKRPHIYMGLKNEKIDVGRGVGKGFLNVIRDLGLREYYQSSVELQTGEIARDLAYYLNVSEQIPSAVSLGVYVEPDNSVKAAGGFMIQTMPETRTEIVEFLERKLSETQSTSSMILQGMDSLQILEEVVGLPIEVLHRGTVTYFCPCTKDRVINAIVTLGREEIQKMIEEGKTVDVECYFCKKKYEVTVEELKILLREI
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q112R6
MADQLIRAMAAEGGIRAVGVITTRLTEEARQRHKLSWVASVVLGRTMAAGLLLASSMKTPESRVNIRVQGNGPLGEVLVDAGLDGTVRGYVNNPTIELLPNKIGKHDIGKAVGNQGYLYIVRDIGYGYPYSGTVELVSGEIGDDITHYLAKSEQTPSALVLGVFVDKEGVQTAGGILLQVMPKVAIDEELVQVLESRIASLSGFTSLLHSGKTLPEIFQELLGDMGLNILPEAQIVRFKCDCSMEKVLRALRMFGVDELQNMIEEDKGAEVTCEFCSQLYQASPKELTQIIQDLQQPSTEVPLGQLRRSSH
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q9KNK2
MANNMLHRYLFKDLSVRGELVQLDDTYQQMISSQEYPAAVQHLIGELLVATSLLTATLKFEGSITLQLQGNGPVSLVVINGDNNQQVRGVARWKGDIADDASLHDMLGKGHLVITIEPKQGERYQGVVGLEGDTLAQVLEGYFERSEQLKTRLWIRVGKHDGKACAAGMLLQIVPDGKGSAEDFEHLEQLTNTIKDEELFALPAEELLYRLYNQETVQLFTPQQISFRCGCSRERSAAAIVTVAREEINDILAQDGAVALHCDYCGTTYSFDSAQVAELYAPSSANGSTLH
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q62EZ9
MEQFHGTTILSVRRGDKVALGGDGQVTLGNIVMKGGARKVRRIYNNQVLVGFAGGTADAFSLLDRFEAKLEKHQGNLTRAAVELAKDWRTDRLLRRLEAMLIAADATTTLVITGNGDVLDPEGGICAIGSGGSYAQAAARALAENTDLSPREIVEKALGIAGDMCIYTNHNRIIETIE
Function: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Catalytic Activity: ATP-dependent cleavage of peptide bonds with broad specificity. Sequence Mass (Da): 19053 Sequence Length: 178 Subcellular Location: Cytoplasm EC: 3.4.25.2
Q72RY8
MPENKIRSTTILCVRKNGKVAIGGDGQVSMGNTVMKNTAKKIRRLYDGKILSGFAGSAADAFTLFELFEKKVQEFGGSLSRSAVELAREWRTDRMLRRLEALLIVADKEESFLISGTGDVISPDEGVIAIGSGGNYALAAARALYDHTNLSPKEIVESSMKIAADICIYTNNHITLEEIL
Function: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Catalytic Activity: ATP-dependent cleavage of peptide bonds with broad specificity. Sequence Mass (Da): 19585 Sequence Length: 180 Subcellular Location: Cytoplasm EC: 3.4.25.2
Q92C74
MELHATTIFAVQHDGKAAMAGDGQVTLGESVVMKHTAKKVRRLFHDKVIAGFAGSVADAFTLFEKFEAKLNEYNGNLERAAVELAQQWRSDSVLRKLEAMLIVMDKDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKRHNGGQMEAKDIARHALEIASEICVFTNDHITVEEL
Function: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Catalytic Activity: ATP-dependent cleavage of peptide bonds with broad specificity. Sequence Mass (Da): 19390 Sequence Length: 179 Subcellular Location: Cytoplasm EC: 3.4.25.2
Q2VYI5
MSESSLPSWHGTTILCLRKDGRVVIAGDGQVSLGATVIKGNARKVRKVGGGSILVGFAGATADAFTLLERLEAKLEKHPGQLTRACVELAKDWRTDRYLRRLEAMMAVADKDVSLVLTGQGDVLEPEDGIIGIGSGGNYALAAARALIDIDGLDAETIARKAMAIAAGICVYTNGNMIVESL
Function: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Catalytic Activity: ATP-dependent cleavage of peptide bonds with broad specificity. Sequence Mass (Da): 19124 Sequence Length: 182 Subcellular Location: Cytoplasm EC: 3.4.25.2
P49617
MTTIVCVRKDGKVAIGGDGQATLGNCIEKGTVRKVRRLYKDKVVTGFAGSTADAFILRDLFEKKLELHQGHLVKSAVELAKEWRTERALRRLEAMMIVANDSEFLLVSGSGDVIEPEQDVLAIGSGGNYAKAAALALLRTENNLSAKEIVAEALKIAGDIDIYSNYNHVIEEV
Function: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Catalytic Activity: ATP-dependent cleavage of peptide bonds with broad specificity. Sequence Mass (Da): 18817 Sequence Length: 173 Subcellular Location: Cytoplasm EC: 3.4.25.2
Q9LNB6
MAEEAKAKGNAAFSSGDFTTAINHFTEAIALAPTNHVLFSNRSAAHASLHQYAEALSDAKETIKLKPYWPKGYSRLGAAHLGLNQFELAVTAYKKGLDVDPTNEALKSGLADAEASVARSRAAPNPFGDAFQGPEMWTKLTSDPSTRGFLQQPDFVNMMQEIQKNPSSLNLYLKDQRVMQSLGVLLNVKFRPPPPQGDEAEVPESDMGQSSSNEPEVEKKREPEPEPEPEVTEEKEKKERKEKAKKEKELGNAAYKKKDFETAIQHYSTAIEIDDEDISYLTNRAAVYLEMGKYNECIEDCNKAVERGRELRSDYKMVAR...
Function: Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity). PTM: Phosphorylated. Sequence Mass (Da): 64585 Sequence Length: 572 Domain: The tetratricopeptide repeat (TPR) domain, forming...
Q43468
MAEEAKAKGNAAFSAGDFAAAVRHFSDAIALSPSNHVLYSNRSAAHASLQNYAEALADAQKTVDLKPDWPKAYSRLGAAHLGLRRHRDAFSAYKTGLQLDPDNAALKSGLADAQAAASRPPPTSPFATAFSGPDMWARLTADPTARANLQDPEFVKIMQDIQKDPNKFNLHLSDQRVMHAIGVLLNVKIQTPNHDENDHDADDDVSEDEVVSQPEPEHEPEAAVEVAEEEEEEEKETRDRKGQAQKEKEAGNAAYKKKDFETAIGHYSKALELDDEDISYLTNRAAVYLEMGKFEDCIKDCEKAVERGKELRSDYKMIAR...
Function: Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity). Mediates the association of the molecular chaperones HSP70 and HSP90. PTM: Phosphorylated. Sequence Mass (Da): 64178 Sequence Length: 572 Domain: The tetratricopeptide repeat (TPR) domain, forming...
Q5XEP2
MADEAKAKGNAAFSSGDFNSAVNHFTDAINLTPTNHVLFSNRSAAHASLNHYDEALSDAKKTVELKPDWGKGYSRLGAAHLGLNQFDEAVEAYSKGLEIDPSNEGLKSGLADAKASASRSRASAPNPFGDAFQGPEMWSKLTADPSTRGLLKQPDFVNMMKEIQRNPSNLNLYLQDQRVMQALGVLLNIQIRTQQAGDDMEIGEEEMAVPSRKEPEVEKKRKPEPEPEPEPEFGEEKQKKLKAQKEKELGNAAYKKKDFETAIQHYSTAMEIDDEDISYITNRAAVHLEMGKYDECIKDCDKAVERGRELRSDYKMVAKA...
Function: Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity). PTM: Phosphorylated. Sequence Mass (Da): 64520 Sequence Length: 571 Domain: The tetratricopeptide repeat (TPR) domain, forming...
Q9STH1
MAEEAKSKGNAAFSSGDYATAITHFTEAINLSPTNHILYSNRSASYASLHRYEEALSDAKKTIELKPDWSKGYSRLGAAFIGLSKFDEAVDSYKKGLEIDPSNEMLKSGLADASRSRVSSKSNPFVDAFQGKEMWEKLTADPGTRVYLEQDDFVKTMKEIQRNPNNLNLYMKDKRVMKALGVLLNVKFGGSSGEDTEMKEADERKEPEPEMEPMELTEEERQKKERKEKALKEKGEGNVAYKKKDFGRAVEHYTKAMELDDEDISYLTNRAAVYLEMGKYEECIEDCDKAVERGRELRSDFKMIARALTRKGSALVKMAR...
Function: Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity). Involved in acclimation to heat. PTM: Phosphorylated. Sequence Mass (Da): 63706 Sequence Length: 558 Domain: The tetratricopep...
Q8ILC1
MVNKEEAQRLKELGNKCFQEGKYEEAVKYFSDAITNDPLDHVLYSNLSGAFASLGRFYEALESANKCISIKKDWPKGYIRKGCAEHGLRQLSNAEKTYLEGLKIDPNNKSLQDALSKVRNENMLENAQLIAHLNNIIENDPQLKSYKEENSNYPHELLNTIKSINSNPMNIRIILSTCHPKISEGVEKFFGFKFTGEGNDAEERQRQQREEEERRKKKEEEERKKKEEEEMKKQNRTPEQIQGDEHKLKGNEFYKQKKFDEALKEYEEAIQINPNDIMYHYNKAAVHIEMKNYDKAVETCLYAIENRYNFKAEFIQVAKL...
Function: Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90 . Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity . Sequence Mass (Da): 66057 Sequence Length: 564 Domain: The TPR repeats form 3...
P25407
MVNKEEAQRLKELGNKCFQEGKYEEAVKYFSDAITNDPLDHVLYSNLSGAFASLGRFYEALESANKCISIKKDWPKGYIRKGCAEHGLRQLSNAEKTYLEGLKIDPNNKSLQDALSKVRNENMLENAQLIAHLNNIIENDPQLKSYKEENSNYPHELLNTIKSINSNPMNIRIILSTCHPKISEGVEKFFGFKFTGEGNDAEERQRQQREEEERRKKKEEEERKKKEEEEMKKQNRTPEQIQGDEHKLKVMN
Function: Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90. Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity. Sequence Mass (Da): 29324 Sequence Length: 252 Domain: The TPR repeats form 3 d...
F8RP11
MADEAKAKGNAAFSAGRFEEAAGHFSDAIALAPANHVLYSNRSAALASIHRYSDALADAEKTVELKPDWAKGYSRLGAAHLGLGDAASAAAAYEKGLALDPSNEGLKAGLADAKKAAAAPPRRAPSGGADAIGQMFQGPELWTKIASDPATRAYLDQPDFMQMLREVQRNPSSLNTYLSDPRMMQVLSLMLNIKIQTPQDSDFSQSSSPSQPPPQQQKQQPETKAREMEPEPQPEPMEVSDEEKERKERKAAALKEKEAGNASYKKKDFETAIQHYTKALELDDEDISYLTNRAAVYIEMGKYDECIEDCDKAVERGREL...
Function: Mediates the association of the molecular chaperones HSP70 and HSP90 (By similarity). Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting. PTM: Phosphorylated. Sequence Mass (Da): 65097 Sequence Length: 581 Domain: The tetratricopeptide repeat (TPR) domain, forming...
P25619
MNDTLSSFLNRNEALGLNPPHGLDMHITKRGSDWLWAVFAVFGFILLCYVVMFFIAENKGSRLTRYALAPAFLITFFEFFAFFTYASDLGWTGVQAEFNHVKVSKSITGEVPGIRQIFYSKYIAWFLSWPCLLFLIELAASTTGENDDISALDMVHSLLIQIVGTLFWVVSLLVGSLIKSTYKWGYYTIGAVAMLVTQGVICQRQFFNLKTRGFNALMLCTCMVIVWLYFICWGLSDGGNRIQPDGEAIFYGVLDLCVFAIYPCYLLIAVSRDGKLPRLSLTGGFSHHHATDDVEDAAPETKEAVPESPRASGETAIHEP...
Function: Probably cooperates with other heat shock proteins in the translocation of polypeptides through membranes. It may counteract the altering effect of heat shock on the plasma membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 37045 Sequence Length: 332 Subcellular Location: Membrane
O74914
MASEGKVLLVASSYYGPFYPDGMNTGVHFAELLIPYQVFREAGYEVQLTSETGKCKFDDHSIKKSALGEVERDAFDNKDNEFWYALKDIKPADKINYKEFCIMFIAGGHAAMFDLPHATNLQTLAQQIYASNGVLAAVCHGPVMLPFVDDTKSPEGRSVVYGKKVTAFNSTGELVMGVSSALRERNMQDLNSLFREAGAEFVDPPTPMSDFTQVDGRIVTGVNPMSAKSTAEAAIKVSQSLRKT
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step . May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Catalytic Activity: H2O + methylglyoxal = (R)-lactate + H(+)...
Q04432
MAPKKVLLALTSYNDVFYSDGAKTGVFVVEALHPFNTFRKEGFEVDFVSETGKFGWDEHSLAKDFLNGQDETDFKNKDSDFNKTLAKIKTPKEVNADDYQIFFASAGHGTLFDYPKAKDLQDIASEIYANGGVVAAVCHGPAIFDGLTDKKTGRPLIEGKSITGFTDVGETILGVDSILKAKNLATVEDVAKKYGAKYLAPVGPWDDYSITDGRLVTGVNPASAHSTAVRSIDALKN
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals . Involved in protection against reactive oxygen species (ROS) . Important for viability in stationary phase. May negatively regulate TORC1 ...
Q08992
MTPKRALISLTSYHGPFYKDGAKTGVFVVEILRSFDTFEKHGFEVDFVSETGGFGWDEHYLPKSFIGGEDKMNFETKNSAFNKALARIKTANEVNASDYKIFFASAGHGALFDYPKAKNLQDIASKIYANGGVIAAICHGPLLFDGLIDIKTTRPLIEGKAITGFPLEGEIALGVDDILRSRKLTTVERVANKNGAKYLAPIHPWDDYSITDGKLVTGVNANSSYSTTIRAINALYS
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively r...
O43084
MPAKTRNVLIACSDYYGPFYKDGENTGAFFLELLHPYLVFRDACFNVDIVTESGKIQFDDHSVAGPAIDKGSKGEEFLSYDDHIASGPELSKAEKYVLENKDDMFWRIVQNSKTADEVNPDKYDIFFVAGGHATLFDFPKATNLQKLGTSIYENGGVVAAVCHGPTLLPFMKRQTSDGSVSIVCGKDVTAFDRVAEDKSKLMEALKKYNLEVLDDMLNDAGANFIKSPNPFGDFVIADGRLVTGSNPASATSTAKTALRVL
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS). Catalytic Activity: H2O + methylglyoxal = (R)-lactate + H(+) Sequence Mass (D...
Q10092
MVLFMKTVQRPEHISLKSCIPFKSLQRQGIVFRLSVRMVMLADDHSISDSALSDSDKNAFKDKNNDFWKAIKNAKNASDINFSDYSIFFAAGGHGTLFDFPSATNLHKGAAKIYSMGGVIAAVCHGPVILPCIKDSTGFSIVKGKTVTAFNEIAEQQMNLMPTFEKYHFKTLNKLFQEAGSNFVDPQEPFDDFVKTDGKLVTGANPASAASTAKAALNSLNS
Function: Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS). Catalytic Activity: H2O + methylglyoxal = (R)-lactate + H(+) Sequence Mass (D...
Q09918
MDERHEAAGETSEKPKVLFLLNSYYGPFYDDGDNTGVNVVDLYEAFKVFEENGFDIVIASDTGDYGFDDKSFRDPAIVDETQSIFSNPDCSLMKKLKNIARLDRLNPSDYVIVYIPGGYGCSFDFPHAKVVQDFLYRFYETKGIICAVAQANIALAYTTNSDGQALCTNRRVTGCTWKDEVQNGVLNVMNRLNFYSFGHIAENIGAIFESPPVYVEDPFIVEDGQLFTGSNTNSAKGVAMEAVRAVLNYDG
Function: May catalyze the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS). Catalytic Activity: H2O + methylglyoxal = (R)-lactate + H(+) Sequence Mass...
Q5EBG6
MEIPVPVQPSWLRRASAPLPGFSAPGRLFDQRFGEGLLEAELASLCPAAIAPYYLRAPSVALPTAQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK
Function: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contrac...
Q5EAC9
MADGQMPFPCHYTSRRRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTAMTRFGVPAEGRSPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSPFGESSFNNELPQDGQEVTCT
Function: Displays temperature-dependent chaperone activity. PTM: Phosphorylated. Sequence Mass (Da): 21673 Sequence Length: 196 Subcellular Location: Cytoplasm
F8G0M4
MSMKQRVIIVGGGPVGLLTALGLAKAGTNVVVLEAESQPSDSPRALVYHFPVLPHLKRLGVLDDCVAAGLMRQNFAWRVHSTSEMIFWDLSCLEGDVELPYALHLGQDKLSRILIEHLKALPNVEVRYSSPVVDCEVGPRSVRVVLGGESPGVIVEGDWLIGADGANSFVRREVLNQNFFGITWPQRYVATNTRFDFDKLGFGKTTMQVDDVYGSVICNIDADSLWRVTFMEDPNLPMEGIRGRIDQVFKELLPTNDPYEVVAFSPYRMHQRVTDRMRNGRVILIGDAAHVTNPTGGLGLTGGMFDAFALTSVLNQVIHD...
Cofactor: Binds 1 FAD per subunit. Function: Involved in the nicotine degradation. Catalyzes the cleavage of 6-hydroxy-3-succinoylpyridine (HSP) by incorporation of oxygen at the 3-position to produce to 2,5-dihydroxypyridine (DHP) and succinic semialdehyde. Catalytic Activity: 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate ...
I6YBZ8
MAIDPNSIGAVTEPMLFEWTDRDTLLYAIGVGAGTGDLAFTTENSHGIDQQVLPTYAVICCPAFGAAAKVGTFNPAALLHGSQGIRLHAPLPAAGKLSVVTEVADIQDKGEGKNAIVVLRGRGCDPESGSLVAETLTTLVLRGQGGFGGARGERPAAPEFPDRHPDARIDMPTREDQALIYRLSGDRNPLHSDPWFATQLAGFPKPILHGLCTYGVAGRALVAELGGGVAANITSIAARFTKPVFPGETLSTVIWRTEPGRAVFRTEVAGSDGAEARVVLDDGAVEYVAG
Function: Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity . In vitro, can hydrate various enoyl-CoA such as (2E)-hexenoyl-CoA, (2E)-octenoyl-CoA, (2E)-decenoyl-CoA, (2E)-dodecenoyl-CoA and (2E)-hexadecenoyl-CoA . May contribute to the persistence of the tuberculosis infection by inducing COX-2 ex...
Q7U2S5
MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWIHVDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPVGSRVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA
Function: Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity. Catalytic Activity: a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O Sequence Mass (Da): 16007 Sequence Length: 151 EC: 4.2.1.-
Q99081
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGAHEGLSPTPFMNSNLMGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPLHDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSD...
Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis . Sequence Mass (Da): 72965 Sequence Length: 682 Domain: ...
O67798
MSEREFLRFGDELDVKNCNTSRSFNGLLMAIGGIIGGTAGMLIALIIAGFMNFMSYWFSDKIVLSMYGAREIPYEEAPWLHQIVEELARRANMPKPKIYLVPMEQPNAFATGRGPGHAAVAVTRGILEILDQEELKGVLAHELAHIKNRDVLVATIAATIAGAIGFLANMAQWALFFGGLNRNEEEEGGGFAEMIGAILMIIIVPIIATIVQLAISRSREYFADETGAKICGCPVALARALKKIEEYVMQVPANVNPGTAHLFIENPLKGGGIMELLSTHPSTEKRIQRLCELARKMGQECI
Cofactor: Binds 1 zinc ion per subunit. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 33031 Sequence Length: 302 Subcellular Location: Cell inner membrane EC: 3.4.24.-
O30004
MMLYFFDPVYMMLAVLGYFVMLLLASTIAPKVASRVSGKFSLFTSMVLLAGMILAISAAIIYLILAYAGVYISFYGLIIFLLIINLLMYLLSPYIINLSYGAQRDERLQMVVNSVARRLNVKPPKAVVVRSPPNAFAYGNFLTGKFVAVSESLMRMLSQEELEAVIGHEIGHHKHRDNAVMLLFGLLPSVIFYLGYALLHSSMRDDRRGAQLAAIGIAAVIVSFIVQILVLAFSRLREYYADFEGVRATNKDAMQRSLAKIHLFYHRYPDYLAPIQDSKFRTLFIYAFTNAVAEPITRADIEALKNMKVSPIQEFLSTHP...
Cofactor: Binds 1 zinc ion per subunit. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 37855 Sequence Length: 335 Subcellular Location: Cell membrane EC: 3.4.24.-
Q64V41
MQYVGIQTQQSRNNLRSGILLILFPCLVAVLTYLFCYLLITFTVEDDYGQYNTLAMTNQMFINLIPYIIGGVLVWFIIAYFTNSSIIKAATGARPLERKENKRIYNLVENLCMSQGMKMPKINIIDDDSLNAYASGINEQTYTITLSKGIIEKLNDEELEGVIAHELTHIRNHDVRLLIISIVFVGIFSMLAQIALRSVYYSSWTRSRNDKNNGAILILVLAMIVAAIGYFFATLMRFAISRKREYMADAGAAEMTKNPLALASALRKISADPDIEAVEREDVAQLFIQHPGKQAKSALSGLSGLFATHPPIEKRIAILE...
Cofactor: Binds 1 zinc ion per subunit. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 36129 Sequence Length: 322 Subcellular Location: Cell inner membrane EC: 3.4.24.-
O31657
MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDPMALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSRSAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHITNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILGSLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGKKRSSLFSTHPDLDERIRRLEAK
Cofactor: Binds 1 zinc ion per subunit. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32865 Sequence Length: 298 Subcellular Location: Cell membrane EC: 3.4.24.-
Q1LTF8
MMRIVIFLLTNLAVMVVFGILLTCVGTHSSNTVRLMIISGLFGFCGAFISLLMSKFIALRSVGGKVISQPQNETEHWLLNIILNQAQKIGITMPQVAIYNAPDMNAFATGPSRNNSLVAVSTGLLQNMPRTEIEAVIAHEISHISNGDMVTITLISGIVNTFVIFISRFLAQLTAGFIGSNNEESNNGNKLVYMIVSTILELAFGILASIIVLWFSRYREFYADAGSANIVGCDKMIAALQRLKTSYEPKVTNNIKIFCINGYQKSLSEFFMSHPPLNKRIEALRYGTYMK
Cofactor: Binds 1 zinc ion per subunit. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 32134 Sequence Length: 291 Subcellular Location: Cell membrane EC: 3.4.24.-
Q8G6T7
MHGHFNGLKTTLLFALMWAIIMLIWWATGGSRQTLSIYIVIGLITTFGTYWFSDKLAIASMGAREVSEQEAPEIYQIVRELSAKAGKPMPRIYIAPTMSPNAFATGRNERHAAVCCTQGILQILNARELRGVLGHELMHVYNHDILTSAIASAMATVISYLGYSLMYFGGGSRDDRDSSGGLGLIGALLSVILAPIAASLIQMAISRTREYDADEDGSLLTGDPEALASALNKISYGAQTTPMRKTAGTQSVSAMMIANPFSAVGFSRLFSTHPPTDERIARLMQMANEMNGTPIAPPTYSTRVGR
Cofactor: Binds 1 zinc ion per subunit. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 33100 Sequence Length: 306 Subcellular Location: Cell membrane EC: 3.4.24.-
Q92743
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTD...
Function: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of p...
Q9R118
MQSLRTTLLSLLLLLLAAPSLALPSGTGRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTD...
Function: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of p...
O06291
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSVVTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTV...
Function: Essential protein that may act as a regulatory protease that is conditionally activated upon appropriate environmental triggers. Catalytic Activity: Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val. Loca...
A6YFB5
MTMLWLAVLLTCGAPAALLPTSGVGCPARCDPSSCSPAPTNCQSGETALRCGCCSVCAAAENERCGEGPEDPLCASGLRCVRNGGVTRCQCPSNQPVCGSDGKTYSSLCRLQAESKAVQGRGVAAIIPIQRGDCQQGQKDPDSPRYKYNFIADVVEKIAPAVVHIELFRILPFFKREVPAASGSGFIVSEDGLILTNAHVVTNKHRLKVERSDGSTYDAQIIDVDEKADIALIKIKAKGKLPVLLLGRSEELRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVVG...
Function: Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans such as biglycan, syndecan-4 and glypican-4. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular spac...
Q9VFJ3
MALRGSHRLEVIFKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAAIIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYP...
Function: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-inde...
O43464
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGV...
Function: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-inde...
Q9RZ06
MILDRDLNLEQFISVVRHGEQVELSAAARERIARARTVIEQIVEGDTPIYGVNTGFGKFENVQIDRSQLAQLQHNLIVSHAIGMGEPLPAEVVRGMLLLRAQSLSLGHSGVRVEVVELLLALLNADALPVVPSQGSVGASGDLAPLAHLALGLIGLGDIEYQGQVRPAADVLAELGLSPVQLQAKEGLALINGTQLMGSLLALALHDAQVLLGTANLAAAMTVEARYGSHRPFQPDVVGLRPHPGALAVAAELREFLAGSEIAPSHLTGDGKVQDAYSLRAVPQVHGATWDALAQAERVLAVEFASVTDNPLIFPETGEV...
PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. Catalytic Activity: L-histidine = NH4(+) + trans-urocanate Sequence Mass (Da): 55536 Sequence Length: 524 Pathway: Amino-acid degradation; L-histidine degradation in...
Q6AKP3
MNSKIEIKPGRLTLAELRRMAKAPVGVRLEEKCKGKINASVQTVGEVIRQGRVIYGINTGFGLLANTIIPNEELEHLQRSLILSHAAGVGAFMADSTVRLMMVLKINSLARGYSGIRLEVIEALVQLLNAEVYPSVPQKGSVGASGDLAPLAHMSIVLLGEGEASYRGQRLSGREGLELAGLSPITLGPKEGLALLNGTQASTAFALQGLFAAEELFATAMVSGSLSLDAALGSRRPFNPLIHAVRGHKSQIDVAASYRQLLEHSEIERSHKFCEAVQDPYSLRCQPQVMGACLNQIRNAAEVIGTEANAVSDNPLVFCK...
PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. Catalytic Activity: L-histidine = NH4(+) + trans-urocanate Sequence Mass (Da): 54631 Sequence Length: 512 Pathway: Amino-acid degradation; L-histidine degradation in...
Q54JI7
MSTTDKIVYLNGNTLKIEDLINIGYRGYNVSITQEVEELIQKGRNVIDDILKSEKTVYGINTGFGLFSDVIIPPDQVKMLQVNLIRSHSSGVGTPLTPERTRMLLALRINVLTKGYSGITLETVKRAIKILNGNCLPLVPEKGTVGASGDLAPLSHLALGMMGEGKMYDFGDSGNTFTSNLDVDVLEYRNFKFSPANEILKRQNLTPIELNAKEGLALINGTQLITSLGAEAVYRCKVLAETANIITAMTFEALKGLTAAYHPLIHAARPHSGQGRVAAFLRSVLHSDQYPSEITLANKDTKKVQDSYTLRCVPQVHGIV...
PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. Catalytic Activity: L-histidine = NH4(+) + trans-urocanate Sequence Mass (Da): 58946 Sequence Length: 539 Pathway: Amino-acid degradation; L-histidine degradation in...
Q7NCB3
MKLLTDWLVLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGITTGFGYFKNRRIPRSAVEQLQQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVRPETLQLLVAMLNRGVHPVVPCRGSVGASGDLAPLAHLALVLTGEGEAEVGGEVLPGAAALARAGLEPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSAFLPHFHRLRPHPGQQSSARNLLVLTEDSALIASHAGCDRVQDAYSLRCAPQVHGASLDAISYAAGVIAIEINSVTDNPLI...
PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. Catalytic Activity: L-histidine = NH4(+) + trans-urocanate Sequence Mass (Da): 54037 Sequence Length: 514 Pathway: Amino-acid degradation; L-histidine degradation in...
Q9RZ05
MSETLYTGISQLATPRPGPQRGAAMGDLHIIEDAALLVRGGVIQWVGPRAAAPTATHVHDLGGRAVVPGLVDPHTHAVWAGDRLSDWEAKLQGATYEEILARGGGIRSTMRATAAADVAELVALARPRLASLRASGATTTEVKSGYGLDFDAELRMLRAVRELQAEFELRPTLLIHVPPQEGRAEYVVGVCAELIPQVAREGLAEALDVFCEKEAFSVEETRTMFAAAQAHGLRVKLHADQFHAIGGTELACEVGALSVDHLEASGAAQIAALAASETVATILPGVTLHLGLPAAPGRQLIDSGAIVAIGTDLNPGSSPL...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
Q6AKP5
MSHQLFRNTRIYSPMDSGQPSAGKAQGKLAHFPNGALLVADGLIVAMGDEEAVLAVAKGGAEVEEVDCGGRCMIPGFVDPHTHMCFAAPREAEFAQRIAGTSYLQILSEGGGILSSVRAVALAGEDELYKSTLHRVQTALSFGTTSLEIKSGYGLDTDNELKMLRVIGRVAVDSCLDIVATFLGAHAIPGQYKTDADAFITMIVEEMLPRVREQGIARFCDVFCERGVFSIEQSRILLKAARAMGLGLKIHADEVTDLGGAGLAAELGACSADHLLAASDTNIRAMSQAGVIATLLPATAYSLRKDYARARVMIENRVAV...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
Q55CY3
MGFDFKLKISNASQLVVISKGKPFLIGKEMSNIEIIENGTMIIDENGIIFDIGTFKEMEEKYKDKSFEKVLDCTGKSVLPGFVDGHTHPVFSGDRVHEFAMKLAGATYLDVHKAGGGIQFTISHTKNSTEDELYQLLIPRLNRMLKNGTTLIEAKSGYGLETETEMKMLKVLDRASKQFQGVEIVSTYLGGHAIPKGMNASEATDDIINKQIPELKRLKDAGEISPANIDVFLEKGFFEYEDTKRILQAGKDIGLECNFHGDELSYMKSGELAGELGCRAISHLEKVSEDGMKAMAATPTFAVLLPTTAYILRLECPPAR...
Cofactor: Binds 1 zinc or iron ion per subunit. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate Sequence Mass (Da): 46887 Sequence Length: 426 Pathway: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. EC: 3.5.2.7
A6H0H4
MKTLIINIKELLQVRDNHIDKVSGTEMGVLPKIDDAFLLIEDNLIANFGSMSNCPTIKTDQTIDAKGKIVLPTWCDSHTHIVYAGNRIQEFVDRIKGLSYEEIANRGGGILNSAKNLNQTSEEDIYNQSKVRLEEIMQQGTGAVEIKSGYGLTVDGEIKMLRVIKKLAANYPIKIKATFLGAHAFPSEYKENHADYINLIVNEMLPKIAAEKLADYIDVFLETGYFSVQETEKIIEAGKKYGLIPKIHVNQFTAIGGIKSCVKHEALSVDHLEIVTNEDIENLKGSKTMPVALPSCSYFISIPYTPARKMIAAGLPLALA...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
Q5L083
MRPLFVRRARQLVTLAGSSAAPLVKEKMSDLGIIENGSVWIENGTIVAVGPDDELVRRFADRLAEAEVIDAKGKTVTPGLIDPHTHLVYAGSREHEWTMRLHGATYMEIMNAGGGIHATTKATREASEEALYEESKRRLDQFLLHGVTTVEAKSGYGLSLEHEIKQLEIAKRLHDTHPVDIVSTFLGAHAVPPEWKHDPDEYVRLVIDEMIPEVSRRGLAEFNDVFCERGVFTPDQARRMLEAGKASGLTPKIHADEIEPYGGAELAAEVGAISADHLLRASDEGIRRMADGGVIGVLLPGTAFFLMTKAADARRLIDAG...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
Q5FRS2
MWDTLWTDIHVATADPALISDQDGYGCIHNAAIGIENGRISWIGAARDLPDAPQNLAHKIHSGNGLWMTPGLVDAHTHVIYAGDRSLEFAERLNGVSYEEIARKGGGIISTVNATRHVSEDELFDVTARRVRRMIAEGTTTLEMKSGYGLTLQDELKQLRVARAIGTALPVRVHATFLGAHALPSEFKDRQDDYVSHLITDILPQAVEEKLIDSIDGFCENIAFTPDQIERLFIAANDLKIPVRLHSEQLSNSGGTKLAARYGALSTDHLEYVVEDDVIDLAHAGTVAMLLPGAFYFIRETRMPPVDLFRKHNVPMGLAT...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
Q9KBE4
MVQHFDTLLVNIGQLLPMESKGPKRGKEMSELQLLEHAALGIRDGKVAFIGTMVEADTFTANQMIDCQGKLVTPGLVDPHTHLIFGGSREHEMALKQQGVPYLEILKNGGGILATVEATRAASEEELITKAICHLNRMLSYGVTTIEAKSGYGLDRETEWKQLRAAKAVGEQHPIDIVSTFLGAHAIPTSHRNDPDRFLDEMADMLGEIKEQNLAEFVDIFTETGVFTVEQSRTFLQKAKERGFGLKLHADEIDPLGGAELAGELGAISADHLVGASDQGIQKMAAAGTIACLLPGTTFYLGKDTYARARDMIDQGLAVT...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
Q5V1C1
MTTLDAVVYGADELVAGPATDGRRLETYEDGAVAIVDGTVAAVGPTTEVTAEYPPESANHAVDADGQAVIPGFVDPHTHALFAGDRSDEFAAKLRGKSYQDILAEGGGILRTVRAVRDADEETLLSNLLAHLDTMLAHGTTTVEVKSGYGLDTETELQMLRVIDSADAVHPVDVVPTFMGAHAVPEGWDTDDYTAAVVDEQVPAVESQGIAEFCDVFCEEGVFSVAQSRRVLEAGAAAGLTPKVHAEELAHIGGTQLAADVGAASADHLLHATGEDIDALVDAAVTPVLLPGTAFGLGAAYADATAFRDRGAPVAVATDF...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
A9AW17
MPHADQLITNIGRLVTGPQAPLRGQQLAQLTAIDQAVVAVQAGNIVALGSQAELSAWTADQTIDAGGYLAIPGFVDPHTHACYAGDRAHEFELRIKGASYSELMAAGGGIMSTVHATRAASKAELVAQTRPRLDQLLAHGTTTVEIKSGYGLDTATELTMLEAIAELAQTHPIGIVPTFMGAHAIPAEYRDNPEAFVDLVVDEMLPAVAAWWQQQTIWQEPLACDIFCENGAFSVAQSQRILVKAKALGFRLKLHVDEFEPLGGTPLAVELGAISVDHLVATPPEHIAILANSETVGVSLPGTPFGLGKSQFSPARSLIE...
Cofactor: Binds 1 zinc or iron ion per subunit. Function: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoy...
Q96NU7
MASGHSLLLENAQQVVLVCARGERFLARDALRSLAVLEGASLVVGKDGFIKAIGPADVIQRQFSGETFEEIIDCSGKCILPGLVDAHTHPVWAGERVHEFAMKLAGATYMEIHQAGGGIHFTVERTRQATEEELFRSLQQRLQCMMRAGTTLVECKSGYGLDLETELKMLRVIERARRELDIGISATYCGAHSVPKGKTATEAADDIINNHLPKLKELGRNGEIHVDNIDVFCEKGVFDLDSTRRILQRGKDIGLQINFHGDELHPMKAAELGAELGAQAISHLEEVSDEGIVAMATARCSAILLPTTAYMLRLKQPRAR...
Cofactor: Binds 1 zinc or iron ion per subunit. Catalytic Activity: 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate Sequence Mass (Da): 46743 Sequence Length: 426 Pathway: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. EC: 3.5.2.7
P31269
MATTGALGNYYVDSFLLGADAADELSVGRYAPGTLGQPPRQAATLAEHPDFSPCSFQSKATVFGASWNPVHAAGANAVPAAVYHHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. PTM: Methylated on Arg-1...
P09631
MATTGALGNYYVDSFLLGADAADELGAGRYAPGTLGQPPRQAAALAEHPDFSPCSFQSKAAVFGASWNPVHAAGANAVPAAVYHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). PTM: Met...
P0AEW0
MTDVLLCVGNSMMGDDGAGPLLAEKCAAAPKGNWVVIDGGSAPENDIVAIRELRPTRLLIVDATDMGLNPGEIRIIDPDDIAEMFMMTTHNMPLNYLIDQLKEDIGEVIFLGIQPDIVGFYYPMTQPIKDAVETVYQRLEGWEGNGGFAQLAVEEE
Function: Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3. Catalytic Activity: This enzyme specifically removes a 32-amino acid peptide from the C-terminus of the precursor of the large subunit of E.coli hydrogenase 3 by cleavage at the C-terminal side of Arg-537. Sequence Mas...
E7FI44
MKNLYLPITIDHIARVEGKGGVEIIIGDDGVKEVKLNIIEGPRFFEAITIGKKLEEALAIYPRICSFCSAAHKLTALEAAEKAVGFVPREEIQALREVLYIGDMIESHALHLYLLVLPDYRGYSSPLKMVNEYKREIEIALKLKNLGTWMMDILGSRAIHQENAVLGGFGKLPEKSVLEKMKAELREALPLAEYTFELFAKLEQYSEVEGPITHLAVKPRGDAYGIYGDYIKASDGEEFPSEKYRDYIKEFVVEHSFAKHSHYKGRPFMVGAISRVINNADLLYGKAKELYEANKDLLKGTNPFANNLAQALEIVYFIER...
Cofactor: Binds 1 nickel ion per heterotetramer. Function: Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The alpha and delta subunits...
Q8U2E5
MRYVKLPKENTYEFLERLKDWGKLYAPVKISDKFYDFREIDDVRKIEFHYNRTIMPPKKFFFKPREKLFEFDISKPEYREVIEEVEPFIIFGVHACDIYGLKILDTVYLDEFPDKYYKVRREKGIIIGISCMPDEYCFCNLRETDFADDGFDLFFHELPDGWLVRVGTPTGHRLVDKNIKLFEEVTDKDICAFRDFEKRRQQAFKYHEDWGNLRYLLELEMEHPMWDEEADKCLACGICNTTCPTCRCYEVQDIVNLDGVTGYRERRWDSCQFRSHGLVAGGHNFRPTKKDRFRNRYLCKNAYNEKLGLSYCVGCGRCTA...
Cofactor: Binds 2 [4Fe-4S] clusters. Function: Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The beta and gamma subunits form the sul...
Q8QHJ9
MAGSRRLAHFFMASCLFLCYTASVNGGKRGNSDKCSYKQGTQTSSMDEGARKLGVTFRYDNCSVNWSPLGKHAIHEVNNISFSHLSCDSQAAVVVHWMASPLGIEHVKGFRVYLEDKNPERKQCQHLILKDPRQLNFSYKTIRMSSQPFSSLAFETDYMVRIVPFPTFLNDSFFPPSFLRTNSCEVLLGPDNLVCKPFWKPKMLNVSQLGSNLHVVFDHAPSTFGFSIYYLYYKLRQEGPFRLKRCKPEQNGPKTTCVLQDVTPGTYAIELRDDSNNTRRQTQYHVSQVHSPWAGPIRAMAITVPLVIMSAFATLFTVMC...
Function: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 83391 Sequence Length: 745 Subcellular Location: Membrane
Q8NFM7
MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLYNITFKYDNCTTYLNPVGKHVIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFETDYFVKVVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMQVSFDHAPHNFGFRFFYLHYKLKHEGPFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVDDTNTTRKVMHYALKPVHSPWAGPIRAVAITVPLVVISAFATLFTVM...
Function: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation . Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK . Mediates JNK activation and may be involved in apopto...
Q8NFR9
MGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCIEASYLQEDTVRRKKCPFQSWPEAYGSDFWKSVHFTDYSQHTQMVMALTLRCPLKLEAALCQRHDWHTLCKDLPNAT...
Function: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and ...
Q8BH06
MGSPRLAALLLSLPLLLIGLAVSARVACPCLRSWTSHCLLAYRVDKRFAGLQWGWFPLLVRKSKSPPKFEDYWRHRTPASFQRKLLGSPSLSEESHRISIPSSAISHRGQRTKRAQPSAAEGREHLPEAGSQKCGGPEFSFDLLPEVQAVRVTIPAGPKASVRLCYQWALECEDLSSPFDTQKIVSGGHTVDLPYEFLLPCMCIEASYLQEDTVRRKKCPFQSWPEAYGSDFWQSIRFTDYSQHNQMVMALTLRCPLKLEASLCWRQDPLTPCETLPNATAQESEGWYILENVDLHPQLCFKFSFENSSHVECPHQSGSL...
Function: Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Is...
O95998
MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG
Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. PTM: N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103:...
O95256
MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERN...
Function: Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation . May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). PTM: N-glycosylated. Location Topology: Single-pass type I mem...