ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q12515
MATFNPQNEMENQARVQEYKVSTGRGGAGNIHKSMSKPSPVLLPLKSNSKTVANNNNNGSNQEKVPRFAIGRGGAGNIFHDPHLTRSAQQLDSNDNINYNDVINDIDDYISPITSDMVDEGGSNPVTNTRSRISATRSHQSLHATTSSPNNNAPIVVGRGGAGNIFFNKKKVASNGGNEEDEIRGGNIEDEDTINANEDNLFVVTSNGNALAAIKSTSKKPKNKLKGKSAPEKFAIGRGGAGNIISPKSSRNTINHNLNDDDEDKFNLKDDNGKEKKKKKKKKSGFFSSLKTMFN
Function: Involved in resistance to cisplatin. PTM: Hyperphosphorylated after treatment with rapamycin in a TAP42-dependent manner. Sequence Mass (Da): 31886 Sequence Length: 295 Subcellular Location: Cytoplasm
O00254
MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNII...
Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 42508 Sequence Length: 374 Subcellular Location: Cell...
O08675
MKILILVAAGLLFLPVTVCQSGINVSDNSAKPTLTIKSFNGGPQNTFEEFPLSDIEGWTGATTTIKAECPEDSISTLHVNNATIGYLRSSLSTQVIPAIYILLFVVGVPANIVTLWKLSLRTKSISLVIFHTNLAIADLLFCVTLPFKIAYHLNGNNWVFGEVTCRITTVVFYGNMYCAILILTCMGINRYLATAHPFTYQKLPKRSFSMLMCGMVWVMVFLYMLPFVILKQEYHLVHSEITTCHDVVDACESPSSFRFYYFVSLAFFGFLIPFVIIIFCYTTLIHKLKSKDRIWLGYIKAVLLILVIFTICFAPTNIIL...
Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Location Topology: Multi-pass membrane protein Sequence Mass (Da)...
B3EWG9
DINGGGATLPQKLYQTSGVLTAGFAPYIGVGSGNGKAAFLTNDYTKLTATELSTYATNLQPTWGKLIQVPSVATSVAIPFRITDWSGISGAGRTGPITVVYRITYMSPDFAASTLAGLDDATKGVSPAPSNVSDAIAQVLPPNDPSAPLDVTNPDDGVAGVQPYPDSGYPILGFTNLIFSAFFTKAFFTKHFGDTNNNDDAITANRFVPLPDNWKTELSTYATNLQPTWGK
Function: Catalyzes auto- and hetero-ADP ribosylation and produces short oligomers by elongating the ADP-ribose chain (up to 6-mer). Binds DNA non-specifically but with high affinity. Forms very stable complexes with circular DNA wherein the circular DNA confers thermostability compared to linear DNA. Catalytic Activit...
Q11208
MEIDLPFKVEYSKSSRASCKGCKNKIEAGILRIAAMVQSAFHDGKQPNWFHEQCFFQKQRPTSAGDIENFENIRFEDQERIKKAIDNCTTVISAGGSKKGAKRSKGENNAIKDFGIEYAKSGRASCRGCEQKILKDQIRIRKTVFDTEVGMKYGGQPLWHHVECFAQLRGELGWLDTGENLPGFQTLKSDDKADVKKALPVIKDEGVSSAKKAKIEKIDEEDAASIKELTEKIKKQSKRLFKFRDEIKNEMSKDDMVALLEANNMEPVKGDSEKLLDQVADLLTFGALLPCTDCKGRQLLFHKSGYLCNGDLTEWTKCTK...
Function: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and f...
A0A0C5XL88
MTTSFWRIATDARTYEADDLSGAGAKITGGRWNEVGVAIVYAASSRALACLETVVHLNSGGLPLNRYLVEIEVPDEVLASAEVATPGNLPVGWDAEPAGRVSISFGSQWAQSQRTALLLVPSVIVPEETNLLINPAHPDAKGIKARKVRKWLYDPRMIRKA
Function: Toxic component of a type II toxin-antitoxin (TA) system. Expression in E.coli inhibits cell growth; bacteriostasis is neutralized by expression of cognate antitoxin ParS. ADP-ribosylates E.coli ribose-phosphate pyrophosphokinase (RPPK, prs) using NAD(+) in vitro; ADP-ribosylates RPPK on 'Lys-182' and 'Ser-20...
Q9NVD7
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSF...
Function: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells ...
Q9EPC1
MATSPQKSPLVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTLLEENEVRTMVDPNSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSF...
Function: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells ...
Q9ES46
MSSAPPRSPTPRAPKMKKDESFLGKLGGTLARKKKTREVTDLQEEGKSAINSPMAPALVDIHPEDTQLEENEERTMIDPTSREDPKFKELVKVLLDWINDVLAEERIIVKQLEEDLYDGQVLQKLLEKLAHCKLNVAEVTQSEIGQKQKLQTVLEAVQDLLRPHGWPLRWNVDSIHGKNLVAILHLLVSLAMHFRAPIHLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEIMMGRFERDAFDTLFDHAPDKLNLVKKSLITFVNKHLNKLNLEVTDLETQFADGVYLVLLLGLLEDYFVPLHNFYLTPDSFDQKVHNV...
Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment ...
Q9HBI0
MEPEFLYDLLQLPKGVEPPAEEELSKGGKKKYLPPTSRKDPKFEELQKVLMEWINATLLPEHIVVRSLEEDMFDGLILHHLFQRLAALKLEAEDIALTATSQKHKLTVVLEAVNRSLQLEEWQAKWSVESIFNKDLLSTLHLLVALAKRFQPDLSLPTNVQVEVITIESTKSGLKSEKLVEQLTEYSTDKDEPPKDVFDELFKLAPEKVNAVKEAIVNFVNQKLDRLGLSVQNLDTQFADGVILLLLIGQLEGFFLHLKEFYLTPNSPAEMLHNVTLALELLKDEGLLSCPVSPEDIVNKDAKSTLRVLYGLFCKHTQKA...
Function: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Location Topology: Peripheral membrane protein Sequence Mass (Da): 37485 Sequence Length: 331 Subcellular Location: Cell junction
Q9ERD8
MELEFLYDLLQLPKEVAQPTEEELPRGGKKKYLSPNSKRNPKFEELQKVLMEWINTTLLPEHIVVRSLEEDMFDGLILHHLFQKLASLKLEVEEISLTSASQRHKLGVILEAVNQNLQVEEKQAKWSVETIFNKDLLATLHLLVALAKRFQPDLPLPDNVQVEVIHIESTKTGLKSDKQVEQLTECKSHKDQPLQDAFDELFKLAPEKVHAVQEAIVSFVNQKLERLGLSVQSLDTQFADGVILLLLIGQLEGFFLHLKEFYLTPSSPTEMLHNVTLALDLLKDEGLFSYPVNPEDIVNKDAKSTLRILYSLFQKHSLRA...
Function: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Location Topology: Peripheral membrane protein Sequence Mass (Da): 37603 Sequence Length: 331 Subcellular Location: Cell junction
O16785
MSTLGRSKTPSRDEPKKPGVFEKLSGTLSRKKKAPEDEHGNQGGAHHATDEDEVLELELEGREALDQSLVPVLARNIWLEEGEIRRYLTKETARDQKLAQVVDLLIYWLNEELADQRIVVRHLQEDLFDGQIIQKLLEKLEQIRIEVPEVSQSEEGQRQKLQIVVQTANRILGQPREQEKWSADLIHQKDFTAIIQLLVLLALHYRAPVRFPDNVVANVVVAQKEHGQVKTHRITEQITTVQTELAPKGTRDAFDTLFDYGPDKLAHVKTSLLAFCNKHLNKINLEVSDLDNQFQDGVFLVLLVGLLEGYFVPLYHFNLQ...
Function: Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance . During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments ...
Q7DMA9
MAVGDQTEQNYLPKKKKSETEDDKRRKKIVPGSLLKAVVRPGGGDSSPVDGDQVIYHCTVRTLDGVVVESTRSESGGRGVPIRDVLGNSKMILGLLEGIPTMHKGEIAMFKMKPEMHYAEIDCPVSAPENFPKDDELHFEIELLDFSKAKIASDDLGVIKKILNEGEGWESPREPYEVKARISAKSGDGHVIFSHTEEPYFFTFGKSEVPKGLEIGIGTMARKEKAVIYVRKQYLTESPLLHIDQDLEEVHFEVELVHFIQVRDMLGDGRLIKRRIRDGRGEFPMDCPLQDSRLSVHYKGMLLNEEKTVFYDSKIDNNDQ...
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Essential protein regulating cell division, adhesion and elongation throughout the plant development and embryogenesis. Required for the spatial organization o...
Q8IV76
MKMRGEKRRDKVNPKSSQRKLNWIPSFPTYDYFNQVTLQLLDGFMITLSTDGVIICVAENISSLLGHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPLLNSETHIEFCCHLKRGNVEHGDSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAACVPQEDRLYLVGNVCILRTQLLQQLYTSKAVSDEAVLTQDSDEEPFVGELSSSQGQRGHTSMKAVYVEPAAAAAAAAISDDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRADPVDLEFSVDQVDSVDQEGPM...
Function: Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body . Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components . Inhibits circadian clock function in cancer cells, when overexp...
Q02548
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVP...
Function: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage . Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes . In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(...
Q1LZF1
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDT...
Function: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specificati...
P26367
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDT...
Function: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regul...
Q751U2
MQSVRQTVLFESEEAWRAGAEQNATAITVHARGGEVVQTRRTWAAAGGPRVRVTWSGGRTVSEVSPQLAAGLSVYVEGGAHVSRDFVQARGQAVFHSAQLELDAVRAWWPRELAVQPEALRWAECAYDIELGRQVRVDEYCALRAGETVALTAAAGGTDEAKVETGVFYPEISDGADVSLSGFRCTWLRDGSGRTDTCQKTLLMYKPAHVHMPEPAVGIELVQPVTLHPVIEVDLSSVSASGPACAHHVFLQLPAQLFVDKFQQPPELLFGEDDLELPEYKVEAWGSEVIYALEPGRVNRVQLHSRYARPGPGRRYEVVP...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q4WU12
MRRRITFVQRPESPFHVDQAVLTSDALSITHLDAAREERATFGFDELPAEIWQVLKSSHELHIRWATERPYEIGAPFSSRISPGLHVYYTPGTARETGVGLCSLLKTVFDESLECQSLRYYSRLPSLQNLVAFIQHKFCDRSDEKCVHHAESILSADSVDVNYDSISHALTVSGYWSTSPGQGWTEQIRKHAADTHQVEVGLLGVESATEPEELKMEPTLFSFPSRHHPLPADATYTVSFPAPTGLHPTLTISMPRASLRRPPAPPDATCALHTYLTLPSWIFGDKYQLSTTDRLFLSSHNLAALRAVAGETDLEAPDWV...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q5A4J4
MRQRTTIYNPYSSHDGIITNLNRTNFQLSSIPNHLFTIENKYTITTTTTQPNKSSLYSAIKELRIQTKFNNNESGIPIFSFHYEPGLNIYAVPQSNVDKLEFWQQVEQLIMELLGIKLSSQQWIANVNSFYYHDIQPQPLLNLKEGWKFNLHPKSNYDYIYNQDKIIIRELLTNVSEIEFNLESGIYKEIGLFLIDEKISTNDDLNLSGIRVILDEDSNTNNKEESIHKTMFHIKPRHRSFDDSTTITTTKIIPQGLHPILSTELNTTTIVIPTDFDVEECKFYYYLNLNKSLIFDQFQNIPIGSQLIINNGNKNLELPE...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q6FX62
MESVRHRIALLFANEADIQDVETVEDGVIVFPNSNITIQDRWTYAIDYELDSIRRISWRNPSSTRQFSVIESRLAPGFNIYSNDKEARLNLFGIQPVYSPMYKSLHSETWKSINEILPGGKNLNIPWNPELCDYDILITANTVQVFSYCSLVEKKKFVKDAGKVEIGLFHVDTEDEEDINLSGLRCTWEDTSNNIGKCEKTTLFYKPFHLYVDDSSDIAPITIENTNGLHPKMKIDLSGIRKDKDCRHFVFSQLPSEIFVDKFQSPGSIVFGLDDLELPDYKVNSLSWGSESIVTLKEGQINEITYFSRYLEPKERASNK...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q6BKZ8
MIRQRTTIFNPTKSNDGIIEAVDSSHLQLSSIDYQCEDKFILQTPKFKYIDKLRIQLNQFHSESILFSKYQAGLNIYCKPKIGDEGFNQEEFFNELNQMMTNLFDIPRDGWINSLDTLFYHEPSTGSESFIEYVRKLTGNESNVNLEVSPNIEYVYDGEKVVLKLNGKSLANTTITKNSKFNKEIGLFLIEKGISSEDDIVLSGLRVILNGDDDKNEEYLQKTLFHVKRRQRQSRGTYSSQVKENGMHPFLKTDIHSDIPNDEDLIQCKLYYYLDLNKSFFVDKYQLPKEFTSYVNFGNTDLELPEYKINEWGSEILMEI...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q4IBD0
MRERVTFIHNDYSLDPEALDNQDAGLLGPQIETVRQDKLTIPFGELPSELTDILQEYEALHIRWASPVKSETMDPFTSRISPGLHVYATPVLPSSCNPTKLCSWLQRFGPLDCSKPEAFTEFQQSTSTSPSFSFYEALEDLHSFITTSSQEFCPELDSVCNARLRSLLTASGLDLSFDKAANALVVSALWPLRPQTVAVPASSARRVEVGIFINDRSQPNMKENELGVAGVLSVLGDQKKPSPTIFTFPARHRRDGSVFTSKFLTPTGLHPTLQLSFNSNKLPSADGECAPYAFLTLPKTIFADRYQLGDELFLASKNLT...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q6CV11
MSVQTIQSESFIEEKRRITVLLDRDGRSVEEKVVNRDGVITIPNQSGHVQDRAVLFVPQLASRPDFIHISWKRNAEADITPIKSYIPYGFNIFTNSSGSIAKFIDTPVGKVYYSDTFEDNALSKWFPPEFVDQLLRYSEDNDLDITVTRGRVEVNRYYELTDDNLFPLNGTESVKTEAGIFQVDTEDDTDTSLSGLRCTWHTGSGALNKCQRTLFFYNQIYADKSSLSEVSLTLSEPVNLHPVVQIDLTSKRPIHNCEYYAYFNLPKYFFIDQFQSIPTLLFGEHDLELPEYKLSGFGSISLFTLQPGSINEVTLHSRYI...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q7RYM7
MRERITFIQKQGDSIEPTTLKIKGGVLNGPEIQAAREDRLTIAIDELPKDLQALLGTAHELHIRYVSSQPYEAITPLLARLPPGFHLFYTPAGQADATSPALCLALNQIFGNVQCENPEKSFTTLPRDRFSHSAAYQFYQPSVDLSPFIALVKEKLCSSSKDQSCAARADRLANASSLDISYDAISHAVKLTATWPYQKQEVHATSRPQTRTEVGVLNSDRPGHLEPHELGISGLLTVLGQDKKPSATMFAFASRHRDAESSFSAEFLEPTGLHPTLKLRLESSKPPIEDAYCSPHAYFTLPKTIFADRHQLSDDLFLAS...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
O94472
MDLQRTNQDTGTTTLFKVVISNTVNYLPKGVWILRNNTIDSLSIAKQFREIKNNINISHLSRENYWVETPFGKVFHSEVVSEEFMQIFIDKGNKALNNEEMIFACMSEKGWNVSLETVPNLDIPVGSYETQLGLPVGLHPKLHVHLKNLHKPEDECSLQGFMYIPPTLFIDRYELSNIAEMHADNLGHVLGIWGETDLEAPSYKLNGTGSFFWFDIYTDDGLLQKDYIDTIIPLHTRYQSPLKGQTYLKTSLTNPKFFWNCDTEDKVNDFRFLFSSKNKYTLQNDPTTLSISIPIADLSYKHVVEWVTNGVAIFSFFYLL...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
Q6C5K1
MRRRATILADLQQHGDKISFKPGDNNKSKLTVSVNAPRQDRFSAPVSNADLDVLNHVADVSVAWGRPSAAQQPVLFAAAYEPGLHVTVVKKQASEPRKWGEEKPSEAAPELVHVAKFLEEQLGLPVDPKTFIESRSDYTYYDPLVGPEAFGHFVDKHSACSDESEEFVNDLDTFNYAQSASFHIDHDKKELVTEVTIPDLEHYFNQKKQHISRACKNDRLEVGIFDLNNLATSYAFRGVAELKGLLHDSTKEKPQETFLVIEPRHNIGAGSVSVDFERPVGLHPKSELKLRHIAIPTDHNDENDGVKHCRLFAKYSAPSS...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the manno...
P25580
MVTRHRVTVLYNAPEDIGNHMRQNDTHLTVRGGSGVVLQQRWLLERTGSLDKSFTRITWRPRADLARSLSVIENELSAGFSVYSNSSDVPERFITNPVYNSFHSEKFDIEQYLPPEVDLNLSWNPEDFTYDISVEPTQIQIVEYRLLKQGEEFTIARVKDEKLEVGVFFVDASDESDVDIGGIRCNWRMDDGKMERCQKTSLLYKQGHIAYNHSTTTTSLYLNEPIGLHPKIMIDLTDFEERPKCMYLMHLQLPLELFIDKFQSSPLLLFGEDDLELPEYSLRDKAWGSESIFELKAGTMNEVTLHTRYIEPSNNKGDKL...
Function: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Aids the autocatalytic processing of PRB1. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthe...
A0A0E3D8L9
MERRTVLITGCSQGGIGSALAEVFHQRGFHVFATARKTEKMKHLRDLDRMTLIPLDVTQESQISAAVELIQKHTGGTLDYLVNNAGDGYIIPVLDCDQLHGRQIFEVNFWGPLRMIQEFSPLLIAARGTIVNINSVASETLPLWLGIYSSSKAALLALSETLRLELKPFGVQVLSVMTGAVQTMIFQTNYRLPPDSAYMTWEKQIAAQAEGSEKASRMSATVYAERVVGDILNRQGGITYRGQMASFAYWVVALMPRFLRATPLLAQVGSQ
Function: Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems . The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl...
Q9Y5H7
MVYSRRGSLGSRLLLLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINID...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 102048 Sequence Length: 936 Subcellular Location: Cell membrane
Q91Y13
MVNLRGYNWKSQQLLLFLIIVAAWEAGSGQLHYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNPPMFPATQKALFILESRLLDSRFPLEGASDADVGSNALLTYRLSTNEHFSLDVPPNHEQVKPLGLVLRKPLDREEAAEIRLLLTATDGGKPELTGTVQLLITVLDVNDNAPVFDRSLYTVKLPENVPNGTLVIKVNASDLDEGVNGDVMYSFSSDVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPL...
Function: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination . Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain . Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 101266 Sequence Lengt...
Q9Y5H6
MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILI...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 103051 Sequence Length: 950 Subcellular Location: Cell membrane
Q91Y11
MRLGNRPEDIRTCVHLRWHIHGLLRQENASVVISKCLRHGAWRLLLWLLLLATWDVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVVSKDRGDLLEVNLQNGILFVNSRIDREELCGQNAECSIHLEVIVDRPLQVFHVEVEVRDINDNPPIFSVAEQKILVAESRLLDSRFPLEGASDADVGENSMLTYKLSSNEFFILDIVNKRGKGKFPVLVLRKLIDREENPQLKLLLTATDGGKPEFTGSVSLLIQVLDVNDNAPVFDRSVYEVKMYENQENKTLVIWLNATDSDEGINKEVEYSFSSLASSIIR...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 106763 Sequence Length: 979 Subcellular Location: Cell membrane
Q91Y20
MSCVAMKYCHESWCLLLSLLLFAIWEPGSGQLRYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPTTEKNLFVSESRALDPHFSLEGASDADIGTNALLTYRLSPSEYFSLEVPTTDELVKPLQLVLKKPLDRERASELHLVVKATDGGKPELTGTLELHITVLDANDNAPAFDRAIYRVKLVENARNGTVVIRLNASDLDEGSNGQILYSFAADVSPKTEATFHIDSVSGEIKVNGKIDFEETNLWKIQ...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 102057 Sequence Length: 946 Subcellular Location: Cell membrane
F1NJ67
MAAPSDPPTAATPPAPPPPARRCLLAPSVEPLLFLATLALGLQVPLATQYLWDRLGAERGYVGPNASSPHGCGNGSGAVDPLREEVEALVAHWNLCINLGGFFVGLFSVTLFGPWSDSVGRRPVLVLPAVGMAVQAAVYLLVMYLRLHVAYLLLGRIISGLLGDYNLILAGCFASVADSSNQRTRTFRVAILEACLGVAGMVASVGGGQWRKAEGYINPFWLVLAASLAAALYAALCLQETVKQRRAAKLLTLQHYKAVYKLYTAPEDLSSRRKLALYSLAFFLLVTVHFGTKDLYVLYELGSPLCWASDLIGYGSAASY...
Function: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force . Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus . Functions at acidic...
Q96NT5
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLL...
Function: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force . Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus . Functions at acidic...
Q6PEM8
MEGRVSSVGSPHSFLNAPVLFRGPVEPLVFLANFALVLQGPLTTQYLWHRFSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLTSLL...
Function: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force . Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus . Functions at acidic...
P35227
MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTASGATTAANGGSLNC...
Function: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-...
P23798
MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKNLTENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNC...
Function: Transcriptional repressor . Binds specifically to the DNA sequence 5'-GACTNGACT-3' . Has tumor suppressor activity . May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a r...
Q5SLL5
MQRLEALGIHPKKRVFWNTVSPVLVEHTLLRGEGLLAHHGPLVVDTTPYTGRSPKDKFVVREPEVEGEIWWGEVNQPFAPEAFEALYQRVVQYLSERDLYVQDLYAGADRRYRLAVRVVTESPWHALFARNMFILPRRFGNDDEVEAFVPGFTVVHAPYFQAVPERDGTRSEVFVGISFQRRLVLIVGTKYAGEIKKSIFTVMNYLMPKRGVFPMHASANVGKEGDVAVFFGLSGTGKTTLSTDPERPLIGDDEHGWSEDGVFNFEGGCYAKVIRLSPEHEPLIYKASNQFEAILENVVVNPESRRVQWDDDSKTENTRS...
Cofactor: Binds 1 Mn(2+) ion per subunit. Function: Involved in gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA (By similarity). Catalytic Activity: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyr...
P13735
MAPIIHKNLTAPELVEWALKLEKDSQLTARGALSVRSYAKTGRSPRDKRIVNTTDVTDNVDWGSVNMKLTEESFEKLKTIAKDYFATCKHLFVMDCFAGHDERYRLKVRVYTTRPYHALFMRNMLIVPTLEELQSFGEPDYVIYNAGEAKADPTVPGVTSTTSVALNFKTREQVILGTEYAGEMKKGILTVMFELMPRMGHLCMHASANVGKSGDVTVFFGLSGTGKTTLSADPRRNLIGDDEHVWTDRGVFNIEGGCYAKAIGLNPETEKDIYEAVRFGAVAENCTLDRRTHEIDFNDESICKNTRVAYPLMHIDGALS...
Function: P60 has the capability to bind to microtubules and membrane vesicles in vitro. Catalytic Activity: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate Sequence Mass (Da): 52457 Sequence Length: 472 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Glycosome EC: 4.1.1.49
G0SF70
MLEARLEQASILKKVVDAIKDLVQDCNFDCNDSGIALQAMDNSHVALVSMMLKAEGFSPYRCDRNIALGVNLTSLTKVLRAAQNEDILTLKAEDAPDVLNLVFESSETDRISEYDLKLMDIDQEHLGIPETEYAATITMPSNEFKRITTDLMAMSESVTIEANKDGVKFSCQGDIGNGSVTLRQHTNVEKPNESIEIELSEPVSLTFSLKYLVNFCKASALSNTVKICLSNEVPLLVEYSLGGSSYLRFYLAPKIGDDE
Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair. PTM: Monoubiquitinated on Lys-164 upon DNA damage, and then polyubiquitinated...
Q9DEA3
MFEARLVQGSVLKRVLEALKDLITEACWDLGSGGISLQSMDSSHVSLVQLTLRSEGFDTYRCDRNIAMGVNLNSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSAEFARICRDLSHIGDAVVISCAKDGVKFSANGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDQQEGS
Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. PTM: Monoubiquitinated by the UBE2B-RAD18 complex on Lys-164. Monoubiquitination at Lys-164 also take...
P12004
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
Function: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand . Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrim...
Q7TMR0
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTV...
Function: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity). Catalytic Activity: Cleavage of a -Pro-|-Xaa bond to release a C-terminal ...
P0A5R5
MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNTFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVLVGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQKGLPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI
Function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Catalytic Activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. Sequence Mass (Da): 23193 Sequence Length: 222 Subcellular Location: Cytoplasm EC: 3.4.19.3
B2HP18
MTKVLVTGFGPYGVTPDNPAQFTAEALDGRTIAGATVVSRIVPGAYFDSIAAAEQAIAEVDPQLVIMLGEYPGRAMLTVERLAQNINDCGRYGLADTAGKVLVGEPTDPDGPVAYHATVPVHEMVLAMRAAGIPADVSDAAGTFVCNHLMYGVLHHIATQNLPIRAGWVHLPCLPMVAALDRNLGVPSMSVETAVAGLVAGIEAAVQHSADTREPVPSRLQI
Function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Catalytic Activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. Sequence Mass (Da): 23185 Sequence Length: 222 Subcellular Location: Cytoplasm EC: 3.4.19.3
Q8ENE4
MKKILLTGFVPFLDNPINPTEEIVQGLHKKSVNGWEVVGEVLPVDFHVTGDHLVELIHKVQPSAIISLGLAAGRNRITPERIAINCNDGPVDNQGYKPDGEKIISDGPDGYFSSLPIKKMVKELENNGIPAKISNTAGAYLCNHVMYRALHEIEQQKLDIFSGFIHIPASHKLALTNNIPSFAQKDLQRAIEICIGCLD
Function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Catalytic Activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. Sequence Mass (Da): 21882 Sequence Length: 199 Subcellular Location: Cytoplasm EC: 3.4.19.3
P42673
MRIVLLTGFEPFDQDPVNPSWEAVRQLDGVQLGSDVKIVARRLPCAFATAGECLTRLIDELHPAMVIATGLGPGRSDISVERVAININDARIPDNLGEQPIDTAVVADGPAAFFTTLPIKAMVKAVREAGIAASVSQTAGTFVCNQVFYLLQHALAGSGVRSGFIHVPFLPEQVAGSQRPSMALDAMVAGLQAAVLTAWHTPVDVKEAGGQVS
Function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Catalytic Activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. Sequence Mass (Da): 22438 Sequence Length: 213 Subcellular Location: Cytoplasm EC: 3.4.19.3
C3JZR3
MRIVLLTGFEPFDQDPVNPSWEAVRQLEGVQLADDVQIIARRLPCAFATAGARLAQLIDELHPEMVIATGLGPGRSDISIERVAINVNDARIPDNLGEQPIDTAVAPDGPAAYFTTLPIKAMVRAVRGAGIAASVSQTAGTFVCNQVFYLLQHALAATAVRSGFIHVPYLPEQVTGSQRPSMALETMVAGLHAAVLAAWQTPVDAKEAGGQVS
Function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Catalytic Activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. Sequence Mass (Da): 22547 Sequence Length: 213 Subcellular Location: Cytoplasm EC: 3.4.19.3
O73944
MKVLVTGFEPFGGEKINPTERIAKDLDGIKIGDAQVFGRVLPVVFGKAKEVLEKTLEEIKPDIAIHVGLAPGRSAISIERIAVNAIDARIPDNEGKKIEDEPIVPGAPTAYFSTLPIKKIMKKLHERGIPAYISNSAGLYLCNYVMYLSLHHSATKGYPKMSGFIHVPYIPEQIIDKIGKGQVPPSMCYEMELEAVKVAIEVALEELL
Function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Catalytic Activity: Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. Sequence Mass (Da): 22822 Sequence Length: 208 Subcellular Location: Cytoplasm EC: 3.4.19.3
Q8NBP7
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRD...
Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their...
Q80W65
MGTHCSAWLRWPLLPLLPPLLLLLLLLCPTGAGAQDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGN...
Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their...
A8T695
MGTVSSRRLWWPLPLLLLLLLLGPAGARAQEDDDGDYEELVLALRSEEDGLADALQHGATATFHRCAKEPWRLPGTYVVVLKEETHRSQPERTARRLQAQAARRGYLIKLLHVFHDLLPGFLVKMSRDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPARYRADEYQPPNGGSLVEVYLLDTSIQSGHREIEGRVMVTDFGSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASLRSLRVLNCQGKGTVSSTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVAAAGNFRDD...
Function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their...
O51265
MKNINLILAWLVHIFTASGLIVGLYSIISIVNGNYSLLLKLTVIGLIIDGIDGTMARKLKVKELIPEIDGTLLDNITDYINYTFIPVIFFYLGEFIEEKYKVAICIGILLSSAYQFSRTDAKTNDNYFRGFPSLWNLFVILNIIFKMEQITNLITMSICIITSFIPIKFIYPSKTKELRKITIPITIISCLIFVVSIFSELSTTALKMAKTVLILYFAYLTLASIYLTYKTRNR
Function: Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP. Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26678 Sequence Length: 234 Subcellular Location: ...
Q89LF9
MILWRIVRPGAAMAYVQTGLVLIAEAMDTQQDSLKPRPAMRAAAFSVHVFTAFGAAIALLAMLEAVREHWAAMFQWLGVALIIDAIDGPIARRLDVKNVQPNWSGDVLDLVVDFVTYVFVPAYAIVASGLLLPVAAPLLGVAIIVTSALYFADLRMKADDNHFRGFPALWNAAAFYLFLLHWPPLWSTLLVAALVVLTFVPFHVLHPVRVVRLRWLTMSLIGIWAVLSLYTLDMDFRVGPGVTLALCAIALWISFSDALIRFARSFA
Function: Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP. Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 29487 Sequence Length: 267 Subcellular Location: ...
Q5ZV56
MNPIKPPFTLNQYFAAWFVHVFTASAACIGVFSLYKIYQHDYVFALWLMAITVFIDAVDGSLARLVHVKSVLPKIDGALLDNIVDYLNYVITPCFFLLVKPGMLPADYVVPITAAITITSAYQFCQDDAKTPDHFFKGFPCYWNITVFYMYIFNTSMIVNTVLLSLFCVLIFIPVKYVYPSRLDYLTESRVLKILMHCCSALYGISSFCLLVNYPETNKLWVSLSLGYVGMYLFLSFYRTYYPMFKAKITANNKD
Function: Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP. Affects virulence of this bacterium when there is a complete loss of phosphatidylcholine formation due to absence of both the synthase (pcs) and the methylation (pmtA) pathways. Reduced virulence results from lowered yields of bact...
Q9LVZ7
MSAAAAETDVSLRRRSNSLNGNHTNGVAIDGTLDNNNRRVGDTNTHMDISAKKTDNGYANGVGGGGWRSKASFTTWTARDIVYVVRYHWIPCMFAAGLLFFMGVEYTLQMIPARSEPFDLGFVVTRSLNRVLASSPDLNTVLAALNTVFVGMQTTYIVWTWLVEGRARATIAALFMFTCRGILGYSTQLPLPQDFLGSGVDFPVGNVSFFLFFSGHVAGSMIASLDMRRMQRLRLAMVFDILNVLQSIRLLGTRGHYTIDLAVGVGAGILFDSLAGKYEEMMSKRHLGTGFSLISKDSLVN
Function: Functions as phosphatidylcholine:diacylglycerol cholinephosphotransferase that catalyzes the transfer of the phosphocholine headgroup from phosphatidylcholine (PC) to diacylglycerol, a major reaction for the transfer of 18:1 into phosphatidylcholine for desaturation and also for the reverse transfer of 18:2 a...
Q9LVZ6
MSDAVTKTVAPLRRKANPINGKHTNGVTIDGIFDDHNRQIGPINSQMEDIAQKTDDGGGGEWTSKASFMTWTMHDIIYVARHHWIPCLFAAGVMFFTVVEYTFQMTPASSQPFDLGFVATRYLHSILASSPNLNTVLAALNTILVGMQTTYIGCTWAVEGRPRATIAALFMFTCRGILGYSTQLPRPQEFLGSGVDYPVGNVSFFLFYSGHVAGSMIASLDMKRMQRFRLAMVFDILNVLQSIRLLGTRGHYTIDIAVGVGAGILFDSLAGKYEEMSKRHLRNTRCSLISKDSLVT
Function: Functions as phosphatidylcholine:diacylglycerol cholinephosphotransferase that catalyzes the transfer of the phosphocholine headgroup from phosphatidylcholine (PC) to diacylglycerol, a major reaction for the transfer of 18:1 into phosphatidylcholine for desaturation and also for the reverse transfer of 18:2 a...
Q4WXX9
MATDIATRELRKPVDVAEYLFRRLHEVGIRSVHGVPGDYNLAALDYLPKCGLHWVGNCNELNAGYAADGYARVNGISALITTFGVGELSAINAIAGAYSEFVPIVHIVGQPHTRSQRDGMLLHHTLGNGDYNVFARMNAGVSTTVGRLNDTHEVATLIDNAIRECWIRSRPVYITLPTDMVTKKIEGERLNTPIDLSLPANDPEKEDYVVDVVLKYLHAAQRPVILVDACAIRHKVLQEVHDLMEASGLPTFVAPMGKGAVDETHKNYGGVYAGDGSNTGVREQVESSDLILSIGAIKSDFNTAGFTYRIGQLNTIDFHS...
Cofactor: Binds 1 Mg(2+) per subunit. Catalytic Activity: a 2-oxocarboxylate + H(+) = an aldehyde + CO2 Sequence Mass (Da): 62999 Sequence Length: 569 EC: 4.1.1.1
Q2UKV4
MATDIATRDLRKPIDVAEYLFRRLREVGVRAVHGVPGDYNLVALDYLPKCDLHWVGNCNELNAGYAADGYARINGMSALVTTFGVGELSALNAIAGAYSEFVPIVHIVGQPHTKSQKDGMLLHHTLGNGDFNVFTRMSADISCTLGCLNSTHEVATLIDNAIRECWIRSRPVYISLPTDMVTKKIEGERLDTPLDLSLPPNDPEKEDYVVDVVLKYLHAAKKPVILVDACAIRHRVLDEVHEFVEKSGLPTFVAPMGKGAVDETHKNYGGVYAGTGSNPGVREQVESSDLILSIGAIKSDFNTTGFSYRIGQLNTIDFHS...
Cofactor: Binds 1 Mg(2+) per subunit. Catalytic Activity: a 2-oxocarboxylate + H(+) = an aldehyde + CO2 Sequence Mass (Da): 62927 Sequence Length: 570 EC: 4.1.1.1
P51844
MEGETLPLAQYLFKRLLQLGVDSIFGVPGDYNLTLLDHVVPSGLKWVGNCNELNAGYAADGYSRIKDIGAVVTTFGVGELSAINAIAGAYAEKAPVVHIVGTPMRASQESRALIHHTFNDGDYQRFDAIQEHVTVAQVSLSDHRTAPSEIDRILLQCLLHSRPVRIAIPVDMVPVLVPVAGLSSKIQIPPAVRQPQAEEAALNAVLKRIYSSKKPMILVDGETRSFGMLQRVNHFIQTIGWPTFTSGFGKGLVDETLPNVYGVCTLHQKAFVDSCDLVLVFGPHFSNTNSYNYFLKPADEKSVLFSPNSIQVNKDVFRDL...
Cofactor: Binds 1 metal ion per subunit. Catalytic Activity: a 2-oxocarboxylate + H(+) = an aldehyde + CO2 Sequence Mass (Da): 64071 Sequence Length: 577 EC: 4.1.1.1
P87208
MADIATRELRQPIDIAEYLFRRLHEVGIRSVHGVPGDYNLAALDYLPKCGLHWVGNCNELNAGYAADGYARVNGIAALVTTFGVGELSAINAIAGAYSEFVPIIHIVGQPHSRSQKDGLLLHHTLGNGDYNVFSSMNKGISVTTANLNDTYDAATLIDNAIRECWIHSRPVYLALPTDMITKKIEGERLKTPIDLSLPANDPEKEDYVVDVVLKYLHAAKNPVILVDACAIRHRVLEEVHDLIEVSGLPTFVAPMGKGAVNETHRCYGGVYAGTGSNPGVREQVESSDLILSIGAIKSDFNTAGFSYRIGQLNTIDFHST...
Cofactor: Binds 1 Mg(2+) per subunit. Catalytic Activity: a 2-oxocarboxylate + H(+) = an aldehyde + CO2 Sequence Mass (Da): 62599 Sequence Length: 568 EC: 4.1.1.1
P33287
MVAQQQGKFTVGDYLAERLAQVGVRHHFVVPGDYNLILLDKLQAHPDLKEVGCANELNCSLAAEGYARANGISACVVTYSVGALSAFNGTGSAYAENLPLVLISGSPNTNDPSQYHILHHTLGHPDYTYQYEMAKKITCCAVAIPRAIDAPRLIDRALRAAILARKPCYIEIPTNLAGATCVRPGPISAITDPITSDKSALEAAAKCAAEYLDGKLKPVILVGPKAGRAGSEKELIEFAEAMGCAVALQPAAKGMFPEDHKQFVGIFWGQVSSDAADAMVHWADAMICVGAVFNDYSTVGWTAVPNIPLMTVDMDHVTFP...
Cofactor: Binds 1 metal ion per subunit. Catalytic Activity: a 2-oxocarboxylate + H(+) = an aldehyde + CO2 Sequence Mass (Da): 62263 Sequence Length: 570 Pathway: Carbohydrate metabolism; pyruvate metabolism. Subcellular Location: Cytoplasm EC: 4.1.1.1
P06672
MSYTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNELNCGFSAEGYARAKGAAAAVVTYSVGALSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGKTDYHYQLEMAKNITAAAEAIYTPEEAPAKIDHVIKTALREKKPVYLEIACNIASMPCAAPGPASALFNDEASDEASLNAAVEETLKFIANRDKVAVLVGSKLRAAGAEEAAVKFADALGGAVATMAAAKSFFPEENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVFNDYSTTGWTDIPDPKKLVLAEPRSVVVNGIRFP...
Cofactor: Binds 1 Mg(2+) per subunit. Catalytic Activity: a 2-oxocarboxylate + H(+) = an aldehyde + CO2 Sequence Mass (Da): 60926 Sequence Length: 568 EC: 4.1.1.1
Q9Y233
MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTK...
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides . Can hydrolyze both cAMP and cGMP, but has...
Q8CA95
MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPIF...
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides . Can hydrolyze both cAMP and cGMP, but has...
Q9HCR9
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKT...
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP . Catalyzes the hydrolysis of...
Q9EQT1
MHRLILVSILVCANFCCYRDTFATPQSASIKALRNANLRRDESNHLTDLYRRDENIRVTGTGHVQSPRFPNSYPRNLLLTWRLHSQEKTRIQLAFDHQFGLEEAENDICRYDFVEVEDVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFQSDDYFVAKPGFKIYYSFVEDFQPEAASEINWESVTSSFSGVSYHSPSVMDSTLTADALDKAIAEFDTVEDLLKYFNPASWQDDLENLYMDTPRYRGRSYHERKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTLNWKSCTCSS...
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blo...
V5NC32
MFPRVVRLNSRLVSFALLGLQIANGAITYQHPDDLPSNVNYDFIVAGGGTAGLVVASRLSENSDWNILVIEAGPSNKDTPETRVPGLADSLPGSRTDWNYTTIPQDALGGRSLNYSRAKVLGGCSTHNGMVYTRGSEDDWNYWAEVTGDQALSWDSVLPIMKKAEKFSQDFSDQSVDGHIDPAVHGRDGLLSVVASYTNVSFNDLLLQTTKELSDEFPFKLDLNDGKPHELAWTQYTIDHNAERSSSATSYLETTGDNVHVLVNTHVTRIVSAGNGTNFRSVEFAVDSNSPKKVLQAKKELILSAGVIASPQVLMNSGIG...
Cofactor: Binds 1 FAD covalently per subunit. Function: Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin. The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses t...
Q3L245
MLPRVTKLNSRLLSLALLGIQIARGAITYQHPDDLPSGVDYDFIVAGGGTAGLVVASRLSENSNWKVLVIEAGPSNKDAFVTRVPGLASTLGAGSPIDWNYTTIPQDGLDGRSLDYPRAKILGGCSTHNGMVYTRGSKDDWNSWAGIIGDQGLGWDSILPAIKKAEKFTQDFTDQSVKGHIDPSVHGFDGKLSVSAAYSNISFNDLLFETTKELNAEFPFKLDMNDGKPIGLGWTQYTIDNHAERSSSATSYLESTGDNVHVLVNTLVTRVLSASGNGTDFRKVEFAVDANSPKKQLEAKKEVIVAGGVIASPQILMNSG...
Cofactor: Binds 1 FAD covalently per subunit. Function: Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin. The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses t...
Q02332
MRFSRKLLGPFVGSLAKKLDYYSQFQPSSLTIQQYLDFGRIGTSANSYTFLKNELLVRLANIMQEFTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASDSSPEQVARFNDQLTVVLKRHAHVVETMAEGLIELRESDGVDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGNVLPESPRHVGCIDPACDVESVVYDAFENARFLCDRYYLTSPSMKLEMHNAVEKGKPISIVAVPSHLYHMMFELFKNAMRATVEYHGVDDDLPDIKVYVVKGQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPPRDGTQAPLA...
Function: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity). Required for normal lifespan . Catalytic Activity: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L...
Q11067
MALIKLLLASLAITSVCGMYSKKDDVVELTEANFQSKVINSDDIWIVEFYAPWCGHCKSLVPEYKKAASALKGVAKVGAVDMTQHQSVGGPYNVQGFPTLKIFGADKKKPTDYNGQRTAQAIADSVLAEAKKAVSARLGGKSSGSSSSGSGSGSGKRGGGGSGNEVVELTDANFEDLVLNSKDIWLVEFFAPWCGHCKSLEPQWKAAASELKGKVRLGALDATVHTVVANKFAIRGFPTIKYFAPGSDVSDAQDYDGGRQSSDIVAWASARAQENMPAPEVFEGINQQVVEDACKEKQLCIFAFLPHILDCQSECRNNYL...
Function: May function as a chaperone that inhibits aggregation of misfolded proteins (By similarity). May negatively regulate the unfolded protein response (UPR) through binding to UPR sensors . Catalytic Activity: Catalyzes the rearrangement of -S-S- bonds in proteins. Sequence Mass (Da): 47728 Sequence Length: 440 S...
Q9V438
MRQLASILLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLG...
Function: Binds to both apoptotic cells and phagocytes and promotes Drpr-dependent phagocytosis of apoptotic cells. Catalytic Activity: Catalyzes the rearrangement of -S-S- bonds in proteins. Sequence Mass (Da): 46752 Sequence Length: 433 Subcellular Location: Endoplasmic reticulum lumen EC: 5.3.4.1
Q15084
MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVL...
Function: May function as a chaperone that inhibits aggregation of misfolded proteins . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling . May also regulate the UPR via the EIF2AK3 UPR sensor . Plays a role in platelet aggrega...
Q8N807
MDLLWMPLLLVAACVSAVHSSPEVNAGVSSIHITKPVHILEERSLLVLTPAGLTQMLNQTRFLMVLFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGFGKVDITIEKELQQEFGITKAPELKLFFEGNRSEPISCKGVVESAALVVWLRRQISQKAFLFNSSEQVAEFVISRPLVIVGFFQDLEEEVAELFYDVIKDFPELTFGVITIGNVIGRFHVTLDSVLVFKKGKIVNRQKLINDSTNKQELNRVIKQHLTDFVIEYNTENKDLISELHIMSHMLLFVSKSSESYGIIIQHYKLASKEFQNKILFILVDADEPRNG...
Function: Probable redox-inactive chaperone involved in spermatogenesis. PTM: N-glycosylated. Sequence Mass (Da): 66657 Sequence Length: 584 Domain: The thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity. Subcellular ...
Q9DAN1
MELLWTPLLLVAACLSEVLGSPEIDTGINISQPLHILEDHNLMVLTPAGLTQTLNETRFLMVIFHNPSLKQSRKLAKELGKAAEIFGKGKNGLGFGKVDITKETELQQEFDITHAPELKLFFEGNRLKPISCKDVVESTALVVWLRRQISKKALLFNNSDEVADFVKSRPLVIVGFFQDLEEEVAELFYDTIKDFPELTFGAIQIKNSFGRFHVILDSVLVFKKGKIVKRQELINDSTNKDHLNQVIKQQLTGFVIELNPENKDLIYELNILNHMLLFISKSSEPYSTISRHYRQIAKEFQNKILFVLVNADEPKNKRIF...
Function: Probable redox-inactive chaperone involved in spermatogenesis. PTM: N-glycosylated. Sequence Mass (Da): 67759 Sequence Length: 588 Domain: The thioredoxin domain lacks the conserved redox-active Cys at position 414 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity. Subcellular ...
Q9BY77
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQVPQQKAMAPLHPHPAGMRINVVNNHQAKQNLYDLDEDDDGIASVPTKQMKFAASGGFLHHMAGLSSSKLSMSKALPLTKVVQNDAYTAPALPSSIRTKALTNMSRTLVNKEEPPKELPAAEPVLSPLEGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVV...
Function: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 ...
Q00002
ARDMTKQALPAVSEVTKDTLEEFKTADKVVLVAYFAADDKASNETFTSVANGLRDNFLFGATNDAALAKAEGVKQPGLVCTSPSTTARTSSPRPSMRTYPRLRKVASTPLIGEVGPETYAGYMAAGIPLAYIFAETPEEREEFAKELKPLALKHKGEINFATIDAKSFGQHAGNLNLKVGTWPAFAIQRTEKNEKFPTNQEAKITEKEIGKFVDDFLAGKIDPSIKSEPIPESNDGPVTVVVAHNYKDVVIDNDKDVLVEFYAPWCGHCKALAPKYEELGQLYASDELSKLVTIAKVDATLNDVPDEIQGFLPSSLFPLA...
Function: Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. Catalytic Activity: Catalyzes the rearrangement of -S-S- bonds in proteins. Sequence Mass (Da): 46275 Sequence Length: 436 Subcellular Location: Endoplasmic ret...
D4B2L8
MPGVRSLLLALAGVSLAPAVLAADASTDSSDVHALKTDTFKDFIKEHDLVLAEFYAPWCGHCKALAPEYEKAATELKSKNIQLAKVDCTEEADLCQEYGVEGYPTLKVFRGLDSHKPYNGARKSPAITSYMIKQSLPSVSVVTAENFEEVKSLDKVVVVAFIGEDDKETNKTYTALADSMRDDVLFAGTSSAELAKKEGVSLPAVVLYKEFDDRKDVYDGKFEAEALKAFIKSSSTPLVGEVGPETYSGYMSAGIPLAYIFADTAEEREQYASDFKDLAKKLKGKINFATIDSKAFGAHAANLNLIPEKFPAFAIQDTVS...
Function: Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. Catalytic Activity: Catalyzes the rearrangement of -S-S- bonds in proteins. Sequence Mass (Da): 57255 Sequence Length: 523 Subcellular Location: Endoplasmic ret...
P54470
MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVEDIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAYGLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPLSQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLNDKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI
Function: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. Catalytic Activity: ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-hist...
Q9XDN5
MDKELLQSTVRKVLDEMRQRPIPLGVSNRHIHLSAQDYERLFPGHPISEKKALLQPGQYAAEQTVTLVGPKGQLKNVRLLGPLRSVSQVEISRTDARTLGIAAPLRMSGNLKGTPGIRLVSPFAELELPSGVIVAQRHIHMSPLDALILRVSHGDMVSVAIEGDDRGLIFNNVAIRVSPDMRLEMHIDTDEANAAGADNPHAFARLVGPR
Cofactor: There are 2 Zn(2+) ions per monomer; Zn(2+) and CoA bind inbetween the 2 domains in each monomer. Function: Involved in 1,2-propanediol (1,2-PD) utilization in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. Also able t...
Q9WYK8
MITDGIMHKVREVYQLLRKEPGIIVGVSNRHVHLSREDLETLFGEGYELTPVKELRQPGQYAAKETVTIVGPKGAIENVRVLGPVRKETQVEISRTDAFRLGVRPPVRDSGDLEGTPGIVIIGPNGILVKEKGVIIAKRHIHMHPKDAEYYGVKDKDIVKVIVESGDRRLIFDDVLIRVREDFALEFHVDTDEANAAMLNTGDLVYIVEF
Cofactor: There are 2 Zn(2+) ions per monomer; Zn(2+) and CoA bind inbetween the 2 domains in each monomer. Function: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. Catalytic Activity: phosphate + propanoyl-CoA = CoA + propanoyl phosphate Sequence ...
Q9XDN4
MNGETLQRIVEEIVSRLHRRAQSTATLSVTQLRDADCPALFCQHASLRILLIDLPLLGQLADAETGDAAARKIHDALAFGIRVQLSLHSQLLPVIPVKKLARLPLVFTDEHGLPLVLHAGSVLSYRDVALLSRGRVVVHRKCIVTAMARDAANARNIQLIKQE
Function: Plays an essential role in assembly and/or stability of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Overexpression impairs BMC formation. Sequence Mass (Da): 17914 Sequence Length: 163 Pathway: Polyol metabolism; 1,2-propanediol degradation. Subcellular Location: Ba...
Q9XDN3
MHLARVTGAVVSTQKSPSLIGKKLLLVRRVSADGELPASPTSGDEVAVDSVGAGVGELVLLSGGSSARHVFSGPNEAIDLAVVGIVDTLSC
Function: Probably forms vertices in the shell of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. Required for structural integrity of BMCs and to mitigate propionaldehyde toxicity. Sequence Mass (Da): 9094 Sequence Length: 91 Pathway: Polyol metabolism; 1,2-propanediol degradati...
O34899
MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLALAELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTAEAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYFFAAARVVNARSGIGDVEYERSAIVFRDRNSSES
Catalytic Activity: 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate Sequence Mass (Da): 21504 Sequence Length: 193 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis;...
B1VB74
MAIYTRTGDAGTTALFTGQRVSKTHPRVEAYGTLDELNAALSLCVCAAKNPQHRQLLENIQLQLFWFSAELASESEQPAPEQRYISSEEIAALEAAIDTAMGRVPPLRSFILPGRSEAASRLHFARTLARRAERRLVELSTEISVRHVLMRYINRLSDCLYALARAEDHDAHQNNIIQKVAERYLAAIRTSATREPAMSLSFQELHQLTRAAVMRAEELQVPVVISIVDANGTQTVTWRMPDALLVSSELAPKKAWTAVAMKTATHELTSAVQPGAALYGLESHMQGKVVTFGGGYALWREGLLLGGLGISGGSVEQDMD...
Function: Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), the cofactor for propanediol dehydratase. Found in the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. PduS and PduO allow regeneration of the adenosylcobalamin cofactor within the BMC. Catalytic Activity:...
P53523
MAIHLTRIYTRTGDNGTTGLSDFSRVAKTDLRLVAYADCDETNSAIGVALALGNPDQKITDVLQQIQNDLFDAGADLSTPMQDSVRNPEYPQLRITQTHIDRLEEWCDTYNTPLPTLNSFVLPGGSPLSALLHVARTVARRAERSAWAAVEAHPGVVSMLPAKYLNRLSDLLFILSRVANTGNDVLWRPGG
Catalytic Activity: 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate Sequence Mass (Da): 20916 Sequence Length: 191 Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis;...
Q8ZNR5
MAIYTRTGDAGTTSLFTGQRVSKTHPRVEAYGTLDELNAALSLCACAAADENHRTLLEAIQQQLFWFSAELASDSEQPSPKQRYISSEEISALEAAIDRAMARVEPLHSFILPGRCEAASRLHFARTLARRAERRLVELATEVNVRQVLMRYINRLSDCLYALARAEDSDAHQANIIREVSKRYLAACQPPHSKETTPVALSFHDLHQLTRAAVERAQQLQVPVVVSIVDAHGTETVTWRMPDALLVSSELAPKKAWTAVAMKTATHELSDVVQPGAALYGLESHLQGKVVTFGGGYALWRDGILIGGLGISGGSVEQDM...
Cofactor: Stoichiometry of heme binding is 2 PduOC:1 heme; the binding pocket is formed by a PduOC dimer. Full-length PduO also binds heme. Function: Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), the cofactor for propanediol dehydratase. Found in the bacterial microcompartment (BMC) dedicated to ...
Q9XDN1
MNTSELETLIRTILSEQLTTPAQTPVQPQGKGIFQSVSEAIDAAHQAFLRYQQCPLKTRSAIISAMRQELTPLLAPLAEESANETGMGNKEDKFLKNKAALDNTPGVEDLTTTALTGDGGMVLFEYSPFGVIGSVAPSTNPTETIINNSISMLAAGNSIYFSPHPGAKKVSLKLISLIEEIAFRCCGIRNLVVTVAEPTFEATQQMMAHPRIAVLAITGGPGIVAMGMKSGKKVIGAGAGNPPCIVDETADLVKAAEDIINGASFDYNLPCIAEKSLIVVESVAERLVQQMQTFGALLLSPADTDKLRAVCLPEGQANKK...
Function: A CoA-acylating aldehyde dehydrogenase required for optimal 1,2-propanediol (1,2-PD) degradation . Optimizes growth in the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by minimizing propionaldehyde toxicity (Probable). Directly targeted to the BMC . NAD(+) and NADH are regenerated internal...
Q9XDN0
MNTFSLQTRLYSGQGSLAVLKRFTNKHIWIICDGFLAHSPLLDTLRNALPADNRISVFSEITPDPTIHTVVQGIAQMQALQPQVVIGFGGGSAMDAAKAIVWFSQQSGINIETCVAIPTTSGTGSEVTSACVISDPDKGIKYPLFNNALYPDMAILDPELVVSVPPQITANTGMDVLTHALEAWVSPRASDFTDALAEKAAKLVFQYLPTAVEKGDCVATRGKMHNASTLAGMAFSQAGLGLNHAIAHQLGGQFHLPHGLANALLLTTVIRFNAGVPRAAKRYARLAKACGFCPAEANDIAAINALIQQIELLKQRCVLP...
Function: An iron-dependent alcohol dehydrogenase required for optimal 1,2-propanediol (1,2-PD) degradation. NAD(+) and NADH are regenerated internally within the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by the PduP and PduQ enzymes, which reduce NAD(+) and oxidize NADH respectively, although th...
B1ZAJ4
MASDDRPLALTLGDPSGIGPEIALAAWRLRGERGVPPFQLIGDPEFLEATAYRLGLSVPVAEVEPDDAVEVFARALPVLPLPSGAKVSATPGAPDSANAGAIVESITAAVDLVRSGAASAVVTNPIAKFVLTRVGFAHPGHTEFLAALAAREGREPPLPVMMLWSELLAVVPVTIHVALRRVPDLLTQELVERTARIVHADLRARFGLEAPRLVLSGLNPHAGESGTMGTEDRDVLAPAVAALRAEGIDIRGPLPADTLFHERARATYDVALAPTHDQALIPIKTLAFDEGVNVTLGLPFVRTSPDHGTAFDIAGKGVAK...
Cofactor: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+). Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Cataly...
Q9K1F9
MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKNLLRARAEALGKSVVLRDFDPESGGAAYGELEVLHIPAVEAVEAGKLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLHKGIINDARASTGFFSGHTEYLAEKSGTGQVVMMLAGKGLRVALVTTHLPLKDVAAAITQPLIESVARILHHDLKHKFGIKNPKILVAGLNPHAGEGGHLGHEETDTIIPALENLRREGINLAGPYPADTLFQPFMLEGADAVLAMYHDQGLPVLKYHSFGQGVNITLGLPFIRTSVDHGTALDLAATGRADSGSLITAVET...
Cofactor: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+). Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Cataly...
P58711
MYQLNQNQTVNTPQKYRPRLALTVGDPGGIGAEVILKALADLEIGHNYDLTVVSNKNLLQETYKQLSSMENLLPLADPNLLKIIDVTVDRETARQINLGTGNAASGAASFAYMDYAIAQTLAGNFDGIVTGPIAKSAWKAAGYNYPGQTELLAQKSGVERFGMLFVARSPYTGWTLRALLATTHIPLRQVADTLTPQLLTQKLDLLVECLEKDFGITSGRIAIAGLNPHSGEQGQLGTEELDWLIPWLESERQKRPHFQLDGPIPPDTMWVKPGQAWYGNAIVQHPADAYLALYHDQGLIPVKLMAFDRAVNTSIGLPFV...
Cofactor: Binds 1 divalent metal cation per subunit. Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Catalytic Activity: 4-(phosphooxy)-L-threonine + NAD(...
A1B0G5
MTEARPIILTCGEPAGVGPELAPKALASGVPFVFLGDPRHLPEGTAWAEVTAPGEPVADGVLAVLRHDFPAPARPGQPDPANAPAVIEVIARAVDLAMSGAAGGICTLPINKEALKRGAGFGFPGHTEYLAHLAGDVPVVMMLASTTVQPPCRVVPVTIHIPLSEVPLALTPLRLEQAIRITDAAMRRDFGLAQPRLAIAGLNPHAGENGVMGDEEARWMAPLIERLRREGFDLRGPLPADTMFHPAARARYDAALCAYHDQALIPIKTLDFAGGVNITLGLPFVRTSPDHGTAFDIAGQGIADAESVIAALRMAHEMAA...
Cofactor: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+). Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Cataly...
C0QTA7
MKKIGITLGDPSGISPEILIKSIDKLKKAIYVIYGSYKIIEKVSSILDKKTEINIIDSPEEAEKEGVYLINVYDRDFCVGKPDKETGKASVLFLERAVKDILSKKLDAIVTLPISKEYVMKAGFRYAGHTDYLADITKTEDYLMMLLCEKMKVALVTTHIPLKDVPENIKPEILESKIRLLNRELQSKFGIKKPKIAVLGLNPHAGDGGNIGREEIDIINPVVQKLKSEGIDLEGSLSADTAFNRYREFDAYLAMYHDQGLIPLKLLCFKKAVNITLGIPFIRTSPDHGTGFDIAGKGIADPSSFIEAVKLALKLSKQY
Cofactor: Binds 1 divalent metal cation per subunit. Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Catalytic Activity: 4-(phosphooxy)-L-threonine + NAD(...
B4S6L0
MKTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIRTIDAPEKAAAYPQGVLPVISVGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAMVTAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDPVSGLMVALATIHVALHRVPELIRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDALADRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSPDHGTSFDIAGQGRASHRSFS...
Cofactor: Binds 1 divalent metal cation per subunit. Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Catalytic Activity: 4-(phosphooxy)-L-threonine + NAD(...
Q9I5U4
MSLRFALTPGEPAGIGPDLCLLLARSAQPHPLIAIASRTLLQERAGQLGLAIDLKDVSPAAWPERPAKAGQLYVWDTPLAAPVRPGQLDRANAAYVLETLTRAGQGCLDGHFAGMITAPVHKGVINEAGIPFSGHTEFLADLTHTAQVVMMLATRGLRVALATTHLPLREVADAISDERLTRVARILHADLRDKFGIAHPRILVCGLNPHAGEGGHLGREEIEVIEPCLERLRGEGLDLIGPLPADTLFTPKHLEHCDAVLAMYHDQGLPVLKYKGFGAAVNVTLGLPIIRTSVDHGTALDLAGSGRIDSGSLQVALETA...
Cofactor: Binds 1 divalent metal cation per subunit. Can probably use ions such as Zn(2+), Mg(2+) or Co(2+). Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP...
Q3IFD2
MTLRIAITPGEPAGIGPDLLLKLAQQTWDAQLVAIADANMLKQRAKHLGLSIKLIEFDQHAAATPAPAGSLYLHQVDVAEPVELGVLNDANGQYVLDTLRIASEKNMDGTFAAVVTGPVHKGIINKAGISFSGHTEYFAQQSNTADVVMMLATQGLRVALVTTHIPLAYVSRAITEDRLIKVASILNHDLQTKFGIEKPRILVCGLNPHAGEDGHLGREEIDTIIPTLEILNNQGMNLIGPLPADTLFQDKYLNEADAVLAMYHDQGLPVLKYKGFGNSVNITLGLPFIRTSVDHGTALDLAGKGTADVGSFELAIREAI...
Cofactor: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+). Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Cataly...
P58714
MLNIAITTGEPAGIGPDITVTALLRLLRQPAPRHADVRWHVIGDAALLQARADAIGLGDAWRDAAAALTVVARPLGAPVRTGVLDAANGRYVLDLLDAAIDGCLPDAAGMARYDAMVTAPVQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAHGNAMLRVALATTHLPLREVPDAITPAVLDETLDIVQRDLRARFGMAAPRILVTGLNPHAGEAGHLGREEIEVIEPAVVRARARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRTSVDHGTALDLAGTGRAEAGS...
Cofactor: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+). Function: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). Cataly...