ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
B1HVP6
MFEKPLGMRDTFPQIFEKVEAVRQTGRDFLTKRGYEFIKTPAVEYFDTVGKASAIADTHLFKLVDSQGNTLVLRPDMTTPIARVATSKLLKEMIPQRLAYFASVFRAQEAEGGRPAEFDQMGIELIGDQSVFADAEVIVTAMELLKHLKLEAFKVTIGHAGILNCILQDYTESIEQQTTLRTLLVHRNYVGFEEAVDSFNLPKAKADALLQFIEEAMDVKDIRDIEKYVRKNDALVYMQQLAQLLEMADLAAYVTFDFTLSSHMSYYTGMLFEVFALGSGFPLGNGGRYDGLLEVFGSKAGATGFSIRVDRLLETLHGQS...
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Sequence Mass (Da): 42992 Sequence Length: 385 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: s...
Q2W2D0
MTESANRALLPAGLRDMLPPDAEFEASVVHSLMSMFARHGYDRVKPPLIEFEESLLDGAGGGTSSQTFRVMDPMSQKMMGLRADMTPQVARIAATRLGSQPRPLRLSYAGQVLRVKGTQLRPERQFGQAGIELIGSDDAGADAEVLVMTAEALDDLGVPGVSADLALPTLVPAVFAAYGINGETADRLRAALDHKDSATVAAQGGAAAPLLQALIAAAGPAARALAELCALDLPPAAAAERDRLARVVELAGADLPSLTLTVDPVENRGFEYHTGLSFTLFARNMGAELGRGGRYQGGGGEPATGATLFMDSVLAALPGP...
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Sequence Mass (Da): 39612 Sequence Length: 379 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: s...
A6VYL1
MTLADRWLLPEGVDEALPEQAAKIEHLRRTLLNLHESWGYHLVIPPLLEYLDSLLTGAGSDLEIETFKVIDQLSGRLLGIRADFTSQVARIDAHCLKDDGVQRLSYCGSVLRTMPAGLDGTRSPIQLGAEIYGHGGVESDVEVLSLMLQTLSTAGLSNLVLDLGHVDIVSGVLAACNLNADQESKLIELYKAKDLPELDRYAEELGCLTDIQKQWLVGLPRLCGGKEVLKHATDLLGDVNESIRDAIVLLQKVSDSICQRFPKVGLHFDLSDLVSYSYHTGVIFAAYVPGHGNAIARGGRYNNIGQVFGRSRPATGFSTD...
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Sequence Mass (Da): 42886 Sequence Length: 392 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: s...
Q2RGV6
MASNLPLQLPAGVSDLLPPEAAALRQLEQRLLNCFRSWGYQEVMTPTFEFATTFQAGSPAGEEGALYKFIDRQGRVLALRPEMTAPIARLVATSLRRRELPLRLGYSARVFRYEEPQAGRRREFHQAGVELIGAGGVAGDVEIIALAVESLAQAGLEDFRLGLGQVAVTKGVLQDLALPPEAVAGIKSALASKDLVALERIYDEYHLEGERRRRLELLATIHGGREALEEARACFGRTAAAASLAELSRVWEALGAAGLEKWLFIDLGILRDFDYYTGIVFEGYVPGLGAPVCGGGRYDGLLAQFGYPCPATGFALGLER...
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Sequence Mass (Da): 41904 Sequence Length: 389 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: s...
Q9K013
MQTWQLPEHIADVLPTNARQLESAREQLLALFRVHGYELVQPPLMEYAHSLLTHIDAGLSLKTILVTDRLSGRQLGIRADITPQVARIDAHLLSANQGINRLCYAGPVLHAQPDGLLNMREPLQAGAEMYGFADIRGDIELIDLMLKSMKIADMGKVLLSLGHIGIFRALSDAAHLDAGQSATLLALMQDKDTGAVEAQVKAWKLDGMWAKAFSLLPRLYGGREVLSDARGRLPDLSAVGGALGELQAVCDAFPDCEIHIDLSELRVDNYHTGLLYAAYAADFHDAVARGGRYDGLGGYFGRARPATGFSFDLRSFIGRL...
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). Sequence Mass (Da): 41746 Sequence Length: 383 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose ...
Q82V28
MRNWLLPEYIEDVLPRDAYRIEKIRRLIMDMLFAHGYQFVMPPLLEYVESLLAGSGSGMNLRMFKVVDQLSGRMMGLRADMTPQAARIDAHLLNISGVTRLCYASSVVHTVPDEITRTREPFQVGAELYGHSGIESDLEIQCLLLECLSVSGIHSIHLDLGHIRVFRSLIRDSGIKPEFEMELYAALWAKDISSLKELVRTGLNKRLTRSVQNALLLLPELYGDGTVLLSARQHLPDFPEIGEALDQLEHVARILQPYVDRITFDLADLRGYHYHTGMVFAVYTPGCPAPIALGGRYDEIGKSFGRARPATGFSLDLKQL...
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Sequence Mass (Da): 43900 Sequence Length: 391 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: s...
Q2YBX1
MNMSAWALPEYIEDILPAEALKIEMMRRRVLDWLFVNGYELVGPPLLEYVESLLTGSGGQMNLRVLKVVDQLSGRMMGLRADMTPQVARIDAHLLNRKGITRLCYAGSVLHARPSGLTRTREPLQIGAELYGHQGLESDLEIQRLMLQSLAIAGVGNIHLDLGHVAVFRGLIRSTGISPDLEMELSGALQGKDKAALKELCAGLKKQVDASVREALQLLPELYGDENVLTLARSALPSYPGIMKALDELEMVASELSPLVDTLAFDLADLRGYHYHSGMVFAAYTDNCPNAIAVGGRYDEVGKAFGRARPATGFSMDLRE...
Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Sequence Mass (Da): 42932 Sequence Length: 393 Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: s...
Q97YX6
MNRDIGKNAERELVSILRGEGFNAVRIPTSNSSPNPLPDIFATKGNTLLSIECKSTWENKVKVKEHQVRKLLDFLSMFTMKGVPLIAIKFKQVHEWRVLVPEKAEDIIVTIDNSIPIEDLFKILEKRIEEKILTP
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Acts only on 4-way DNA junctions in a sequence non-specific manner; introduces paired nicks in opposing strands 2 bases 3' of the point of strand exchang...
O07778
MPITPLLHESVARFAATGADITTRAEPDLFVSIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ
Function: Member of the three-protein two-component system HK1/HK2/TcrA. Kinase that binds ATP and catalyzes the transfer of a phosphoryl group from ATP to HK2. Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Sequence Mass (Da): 17854 Sequence Length: 168 EC: 2.7.13.3
O07777
MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVRELVTILPIVLVIAAVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLATTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPTS
Function: Member of the three-protein two-component system HK1/HK2/TcrA. HK2 transfers its phosphoryl group to TcrA. PTM: Phosphorylated by HK1. Location Topology: Single-pass membrane protein Catalytic Activity: ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Sequence Mass (Da): 16595 Sequence Length:...
Q91W97
MFAVHLVAFYFTKLKEDQIKKVDRFLYHMRLSDETLVDIMARFQAEMEKGLGKDTNPTASVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSQEGQQNVQMESQFYPMPNEITRGNGTELFDYVADCLADFMKTKNLTHKKLPLGFTFSFPCRQNKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHKDLDVDILALVNDTVGTMMTCAYDDPNCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYMGELVRLILLKMAKVGLLF...
Function: Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (By similarity). Has low glucose phosphorylating activity compared to other hexokinases (By similarity). Involved in glucose homeostasis and hepatic lipid accumulation . Required to maintain...
P0DUM0
MLSKYQPSAHIAVTRAHWEDLHQAISSGKVTIDGNSLTLADVVAVSKFGCYARLSENRETIDAINESVSTLQECLDEGHHIYGVNTGFGGSADSRTDHLASLQRALLQLLQSGILTKADIGSGDTPSQSHAMPPEWVKAIMVVRSNSVARGHSAVSIGSIEAILRLLQRDITPVVPLRGTISASGDLMPLAYIVGAIEGNPGVFARAGKSPHGQALPAQQVLEQLGIPRITLGPKEALGLVNGTAASAALSSLVLYEAHRLALLSQVTTALTVEALRGSAESFHPFISQARPHDGQMEAASNILTVMRGSRLAMGTSEVQ...
Function: Phenylalanine ammonia-lyase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines . The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (...
P0DUL1
MTKLDSPQFEPFELTAADYAFPMFYAGCTLSFRLKSPEMGIPVLQTAVERITAHLPFLTGIVIPSAVKDGVMEVHPAACGQSGLEDPQCRVRRLPHLCLPPKTASASANKKHGSGMTYDRNECLIVAPLEAATAAQQHPVIRFQINVLADGIIFTLFANHMVIDGTGLGIITEMLASCCQTADNTGSVPELAGAIDREARTRAMLGTIGRREREKVQFEPVAAESAAPDGHQEVHDASLVDCNFRLSADKIRRIRERAQELGIASASEDDIVTAVLWLCMSEFRSHSGAGKEISACTLLRMVNVRRRFHPAVPDNYLGNC...
Function: O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines . The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (Probable...
P0DUL3
METPTPPLPSKDQLFPPLIQLVRALLWVLVITIGGAIVQRLFFHPLRKIPGPLTAAISGWDEFYHNIWRDGEWCKTYPKLHKEYNSPVIRIGPNHVHLNDIDAYETVFRVGTNFYKDKTFYTCADNDGSIFSLCDRDEHSERRKVLSSLFSKQAAEMTAPKVMSKLNELLDFMITQSKEGKACNITDLFRALAINWVADTLLGDCGDVVTYAETKPDLLEDIDGLSKLIPTLRFFPYLIPTLNSLAPSTSPAGVAKFKKICENYTRPRINDPIKNISQRSRASVVELLIAHRHEVYHKPPTVDYLAEEAFTFIDAGVDTT...
Function: Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines . The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A...
P0DUQ0
MDDFSATHINYTLSIHLSGIFFAWHRHFVWLWERTLREECGYNGYQPYWDWALSANNISASPIFDGSPTSLSGNGDPINQEPFLQLEPTNITIPTGTGGGCVTNGPFANMTLNLPDLSMAGDEEFPSNAFDYKPHCFTRNLNSHMSSAFTSQADVDRLLNSPSITDLQANIDFSAWPELREARILGPHAAAHMSLGRTMDDFWTAPQDPSFMLHHAQVDRIWSLWQARGPESRRWALNGTSTINNRPTSPEVTLDTELVWGSLSESKTMREVMSTEAYHFCYEYGA
Cofactor: Binds 2 copper ions per subunit. Function: Oxidase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines . The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine ca...
P0DUL5
MEIFESFGIEGEVTKQWEPATDEILWCRNESGTLSRMERFRNEPPVGVKWTHGTLQQGRVEEIMKKRITEISGVEVEYSTELSDLTINTRESSNSKASACSVTIRSVADDQEAHRSSETIRARYIIGADGGRSSIRDLMGVAMEGTKGTAIWGVMDILGGSDFPDFGATSVVRSDSDGAVDFVRREEGLTRIYVELNKCAAGWEALERDTITPELILEKCRYIIRPYKLEVDYVEWWSSFTVWQRLSKSMIVHDRVFLVGDAVHTHSPLCGMGMNTGIQDSFNLGWKLAGVVQGQLNYDILQTYETERRPVAEALLDTDR...
Function: FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines . The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (...
P0DUL6
MRDRCMLSFTKEQLTSVGEYCTLHSSPLPKSVEEQCRVTDERSQDEVVMAPSPAQCAWLMSFALASRPRRILELGTFTGVSTLAFYEGTRKTKAEIITVDMSEEYLQIAETAFRRHGATDRIQTIRGPCLEILPTITGEFDLIYIDAAEEEYEAYTRFVLDHKLLSAEGVMLVDDGTYIRWFYFFQANWWSVLLEGLVVDRSIVKEFPEEIQEPYLGIADQMNDFNRYARSDPRVEVTMIPLFNGVTQITWK
Function: O-methyltransferase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines . The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (Probable...
A5FVE7
MAEHDDGDLIAAIRGLARANVLVVGDLMLDRYAYGRVERISPEAPVPILTVTREIAMPGGAGNVVRNLTALDAAAAFVSVVGDDQEGSDLTALIGGQPNVEPWLLVETGRATTVKTRYIAAGQHLIRADRELVMPLTDKLGERLLKIASDAMAATSVTVLSDYRKGVLAPTIARNLIASARSIGRTVIVDPKGADWSHYAEADVITPNRRELAEAVGRDLPDEAAIVGAAREVIGRFGFGAVLCTRSEDGMSLVTVDTVRHYPAEAAEVYDVSGAGDTVVAVLAAGLASGLPLEIAARLSNIAGGLVVGKVGTAVARPDD...
Function: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Catalytic Activity: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) Sequence Mass (Da)...
Q9Z5B5
MTGPMAVRTDRTPLVVVGDALLDRDLTGTADRLAPDAPVPVVQECAERIRPGGAALAAYLAARDGREVTLIAGVGEDPAGLALRELLAPWLKLIPLPLTGTVPEKTRVLAQDRPVVRLDRGGGRVREATDEARDALGCARAVLVSDYGRGAADALRDVLAARPPLVWDPHPRGGPPVPGTRLVTPAEKEAHGFAPSEGRPGGGLRAAALNAAALVRDWRVAAVTVTLGSRGALLSYGEHPLLVPAPAAHHGDSCGAGDRFAATAAGLLADGALVGEAVEGAVGAATAFVAAGGAAAVPPAGSERALAALPDTDDPGALAA...
Function: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Catalytic Activity: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) Sequence Mass (Da)...
P41936
MFNVSALRAATPSIASVSSVASPSEQHGLSTSVGVGVNDTTSRTGDGGAASSASSASAAPQQQSQSALHNKLEAKWDTLLPTDTNLQCSTWPDSIPLLAGYSATPTFSFDPCTYGSYDPSAYFASNGIAGSMYTLPDQFPRSENDMLDNSNTSNGNKSDKDGIKLEDEDEILEDEENDEEDDGTGKRKKRKRRVLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTTMPNAFSSQSTAASFPTRAMPIPMLVRDSSARSSDISSTSPYTVAFGSANSGYLPTPSAYL...
Function: Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. Sequence Mass (Da): 37511 Sequence Length: 346 Domain: The homeobox domain is required for the induction of distal tip cell fate. Subcellular Lo...
P02836
MALEDRCSPQSAPSPITLQMQHLHHQQQQQQQQQQQMQHLHQLQQLQQLHQQQLAAGVFHHPAMAFDAAAAAAAAAAAAAAHAHAAALQQRLSGSGSPASCSTPASSTPLTIKEEESDSVIGDMSFHNQTHTTNEEEEAEEDDDIDVDVDDTSAGGRLPPPAHQQQSTAKPSLAFSISNILSDRFGDVQKPGKSMENQASIFRPFEASRSQTATPSAFTRVDLLEFSRQQQAAAAAATAAMMLERANFLNCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLS...
Function: This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation. PTM: Phosphorylated. Phosphorylation may directly...
P23397
QDEKRPRTAFTGDQLARLKREFSENKYLTEQRRTCLAKELNLNESQIKIWFQNKRAKMKKASGVKNQLALQLMAQGLYNHSSSSSSSSSSSSSIFLLA
Function: This protein specifies the body segmentation pattern. PTM: Phosphorylated in the Ser-rich domain. Sequence Mass (Da): 11143 Sequence Length: 98 Subcellular Location: Nucleus
E4QP00
MTDTIFDYVIVGGGTAGSVLANRLSARPENRVLLIEAGIDTPENNIPPEIHDGLRPWLPRLSGDKFFWPNLTIHRAAEHPGITREPQFYEQGRLLGGGSSVNMVVSNRGLPRDYDEWQALGADGWDWQGVLPYFIKTERDADYGDDPLHGNAGPIPIGRVDSRHWSDFTVAATQALEAAGLPNIHDQNARFDDGYFPPAFTLKGEERFSAARGYLDASVRVRPNLSLWTESRVLKLLTTGNAITGVSVLRGRETLQVQAREVILTAGALQSPAILLRTGIGPAADLHALGIPVLADRPGVGRNLWEHSSIGVVAPLTEQA...
Function: Involved in the degradation and detoxification of 5-(hydroxymethyl)furfural (HMF) by mediating its oxidation to furan-2,5-dicarboxylate (FDCA), a biobased platform chemical for the production of polymers. Active with a wide range of aromatic and aliphatic primary alcohols and aldehydes: acts on alcohol groups...
P30519
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFILAAGVALAAGLLAWYYM
Function: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. PTM: A soluble form arises by proteolytic removal of the membrane anchor. Location Topology: Single-pass...
P43242
MSAEVETSEGVDEPEEKNFGENHIRMADLSELLKEGTKEAHDRAENTKFVKDFLKGNIKKEIFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCSEAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQFYRARMNALDLNLKTKERIVEEANKAFEYNMQIFSELDQAGSAPASETVEDRIPVHDGKGDVRKCPYYAAGQVNGALEGSSCPFRAAMAVLRKPSLQLVLAAAVALAAGLLAWYYM
Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. ...
P23711
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
Function: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. PTM: A soluble form arises by proteolytic removal of the membrane anchor. Location Topology: Single-pass...
Q9C9L4
MATTRLNPSCHFPASTRLSCESYLGLRTTGRISYARTLTAPRGYLAVKANGGQASVVTAAAITEKQQKKYPGESKGFVEEMRFVAMRLHTKDQAREGEKESRSPEEGPVAKWEPTVEGYLHFLVDSKLVYDTLEGIIDGSNFPTYAGFKNTGLERAESLRKDLEWFKEQGYEIPEPMAPGKTYSEYLKDLAENDPQAFICHFYNIYFAHSAGGQMIGTKVSKKILDNKELEFYKWDGQLSQLLQNVRQKLNKVAEWWTREEKSHCLEETEKSFKFSGEILRLILS
Function: Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Plays a minor role in phytochrome assembly and photomorphogenesis. Catalytic Activity: heme b + 3 O2 + 3 reduced [NA...
O70453
MSSEVETAEAVDESEKNSMASEKENHSKIADFSDLLKEGTKEADDRAENTQFVKDFLKGNIKKELFKLATTALSYSAPEEEMDSLTKDMEYFFGENWEEKVKCSEAAQTYVDQIHYVGQNEPEHLVAHTYSTYMGGNLSGDQVLKKETQPVPFTREGTQFYLFEHVDNAKQFKLFYCARLNALDLNLKTKERIVEEATKAFEYNMQIFSELDQAGSIPVRETLKNGLSILDGKGGVCKCPFNAAQPDKGTLGGSNCPFQMSMALLRKPNLQLILVASMALVAGLLAWYYM
Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase 3 could be implicated in some heme-dependent regulatory role in the cell. Catalytic Activity: heme b + 3 O2 + 3 reduced [NADPH--hemopro...
Q9LQC0
MATSRLNASCRFPASRRLDCESYVSLRAKTVTIRYVRTIAAPRRHLVRRANEDQTLVVNVVAAAGEKPERRYPREPNGFVEEMRFVVMKIHPRDQVKEGKSDSNDLVSTWNFTIEGYLKFLVDSKLVFETLERIINESAIQAYAGLKNTGLERAENLSRDLEWFKEQGYEIPESMVPGKAYSQYLKNIAEKDPPAFICHFYNINFAHSAGGRMIGTKVAEKILDNKELEFYKWDGQLSELLQNVSEELNKVAELWTREEKNHCLEETEKSFKFYWEIFRYLLS
Function: Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Plays a minor role in phytochrome assembly and photomorphogenesis. Catalytic Activity: heme b + 3 O2 + 3 reduced [NA...
O73688
MEADKKTTAQTESNRDLSEQIKKVTKDVHVRAESTELMLSFQRGQVTLQQYKLLLCSLYEIYLALEEEMDRNCDHPSVAPIYFPAELARLATIEKDLEFFFGPDWREKIVVPAATERYCHRIRQIGQENPEYLIAHAYTRYLGDLSGGQVLGRIAQKSMKLGGSEGLSFFAFPGVSSPNLFKRLYRSRMNSVELTEEQRSAVLQEALGAFEFNIQVFEDLQKMLNVTENEPGVGTPRSRPATTLQVGGSMIQTNPLFRMVLGLCLALATVSIGLYAL
Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. ...
O52792
MTYVSLADLERAARDVLPGEIFDFLAGGSGTEASLVANRTALERVFVIPRMLRDLTDVTTEIDIFGRRAALPMAVAPVAYQRLFHPEGELAVARAARDAGVPYTICTLSSVSLEEIAAVGGRPWFQLYWLRDEKRSLDLVRRAEDAGCEAIVFTVDVPWMGRRLRDMRNGFALPEWVTAANFDAGTAAHRRTQGVSAVADHTAREFAPATWESVEAVRAHTDLPVVLKGILAVEDARRAVDAGAGGIVVSNHGGRQLDGAVPGIEMLGEIVAAVSGGCEVLVDGGIRSGGDVLKATALGASAVLVGRPVMWALAAAGQDG...
Function: Catalyzes the oxidation of p-hydroxymandelate to p-hydroxybenzoylformate in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, 2 non-proteinogenic amino acids occurring in the vancomycin group of antibiotics. Catalytic Activity: (S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyo...
Q8Y563
MKKVFITTGTEHYLRQLMANYTGGNVTLLQNFSQSLLYQESTGEKLFQEGAEYRVLQSSGSIKGFGVVVFEYIHLRDEEIPIFLQMYQRASLHFSETPGLQSTKLTKAMNMNKFLIISFWDSEVFFHDWKKSPLSKEITNIMRKNNTQSGFSHEDIYHYPEFSHDAK
Function: Catalyzes the degradation of heme to biliverdin in the presence of a suitable electron donor such as ascorbate, with the subsequent release of iron. Hardly any CO is released by the heme degradation reaction. Binds heme . Allows bacterial pathogens to use the host heme as an iron source. Release of iron from ...
Q988D0
MRRKVFEELVTATKILLNEGIMDTFGHISARDPEDPASFFLAQKLAPSLITVDDIQRFNLDGETSDNRPSYLERYIHSEIYKTRPDVQCVLHTHSPAVLPYCFVDTPLRPVTHMGAFIGESVPVYEIRDKHGDETDLFGGSPDVCADIAESLGSQTVVLMARHGVVNVGKSVREVVFRAFYLEQEAAALTAGLKIGNVKYLSPGEIKTAGKLVGAQIDRGWNHWSQRLRQAGLA
Cofactor: Binds 1 manganese ion per subunit. Function: Involved in the catabolism of pyridoxal 5-phosphate (Vitamin B6). Catalyzes the decarboxylation of 3-hydroxy-2-methylpyridine-4,5-dicarboxylate to yield 3-hydroxy-2-methylpyridine-5-carboxylate. The decarboxylation proceeds by an aldolase-like mechanism in which th...
Q88DY1
MLQVEGLYLCRGSNEVLHDIHLQLPPGQVVGVLGPNGAGKSSLLSVLCGELAPDRGRVTLQGRPLADWAGQERARRLAVLPQVSSLGFSFRVEEVVGMGRMPHGTGQRRDAEIVEAALRAADAWHLVARSYLALSGGERQRVHLARVLAQLWPGEEGSTLLLDEPTSMLDPLHQHTTLEAVRRFADCGAAVLVILHDLNLAARYCDRILLLEQGRCHAFATPEAALTPAALKAVYGIDVLVQAHPERGHPLIITR
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 27656 Sequence Length: 255 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q3ICT8
MLCANNVSAQIGQKKLLKHINFYVKPNELVVIIGPNGAGKSSLLKALCGDIKINNGDITLNDRLLSDYSIASLATLRAVLTQNYELDFPFSVAEVVDMAHFAHQADYSKQQLMHFSEQVMQALSVTHLKTHTFTQLSGGEKQRVQLARVLCQIQPSLVANKTPYLLIDEPTSSLDIFHQYDVMAQAKSIASQGAGVVAVIHDLSLAASFADRIYMLNNGEVAACGIPKEVLTPALLKRVYNINARLENNTSEAMPHIQMCY
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28686 Sequence Length: 261 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q1MCZ1
MIEVSGVSVRLSGKTIISDVAFTARAGELTAIAGPNGSGKTTTMKAISGELAYGGSVRIGGGEVKGLKPWQLAAIRGVLPQASTISFPFTVREIVRMGLTSGLNLHPDKAEQTAAAALASVDLTGFEGRFYQELSGGEQQRVQLARVLCQIAEPIVDGKPCWLLLDEPVSSLDISHQLTIMTLARNFCERGGGVIAVMHDLNLTALFADRIVLMKSGRLAAAGSIGEVLTNETMLAVFGCALRINQVPSDGTPFVLAHSAISRP
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 27743 Sequence Length: 264 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q98L75
MIEARDVSVDIAGKRIVGGVDFDARPGEVAAIVGPNGSGKTTFLKALSGEFAYTGRIALNGHNLSSMRPAEMAVHRAVLPQATTLSFPFTVREVVKLGLVGGRSGALPGEDARLPERALARVDLDGFAGRFYQELSGGEQQRVQLARVLCQVWAPVLDGKPRYLFLDEPVSSLDIKHQLIIMNIARDFAKRGGGVVAILHDLNLTSMYADRIFVMHRGRLAATGSPQDVLSDDLIEKVFDCRLRVGVLPAGNMPFVLPQSSVY
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 28452 Sequence Length: 263 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q0SIB7
MSPAFHPLRTRVGEAIEQSLFRRTDPVPPPRPSGAVTLRADGIAVTRGGRPVLDDVSVDVRIGEVLVLVGPNGAGKSTLLAALSGDQDVHTGTVHLDDRDLGEWTALEMAQRRAVLPQQNTVGFSFTARQVITMGRSPWARTPRSDDDAVAIAEAMRICDVVAFADRPFTALSGGERARVALARVLAQRTETILLDEPTAALDLGHQETVMRLARSRAEQGTAVVVVLHDLALAAAYADRIVVLEQGRVAANGPPADVLSEELLTRVYGHPVEVIEHPVTGATLVLPRRDQR
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 31376 Sequence Length: 292 Subcellular Location: Cell membrane EC: 7.6.2.-
Q160G4
MSLDAADITVKLGRTPILHGIGFCAKPGEVSAIVGPNGSGKTTLLRAITGDLPFDGTVRLNGKDTSRMKPWELSAIRAVLPQSAVLAFPFTVAEVVRLGVQAGVCARDCDAPMAALSQVRLAHYADRFYHELSGGEQQRVQLARVLAQVWRPVVGGAPRWLLLDEPVASLDIANQLEVMEITRAYASAGGGVVAVMHDLNLTAMFADHLAILSGGQCLAAGPPEQVMTDAILSQAYGCALRVNTPPPHSATYVLPHAANRL
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 27606 Sequence Length: 261 Subcellular Location: Cell inner membrane EC: 7.6.2.-
Q8EB59
MDRLSYAIGDKAVLNNIRVQFQPGSVTALLGPNGAGKSTLLKALCQEIPSAQGSIKLGHCQLVDWPRAELAKSLAVLPQHASLTFPFTVDEVVAMGLYPLTLSQKEGQQLVTKWLAEVGVLHLARRSYPTLSGGEKQRVQLARVLTQLSQSPFPPILLLDEPTSALDLAQQHKVLALAKNLAHKHAYTVIVVLHDLNQAARYSDRVIVLKQGEIVSEGTPNDALSIDIIRQVWDYEPEFIPAPQGDYPLIF
Function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Location Topology: Peripheral membrane protein Sequence Mass (Da): 27509 Sequence Length: 251 Subcellular Location: Cell inner membrane EC: 7.6.2.-
O60506
MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTV...
Function: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds t...
Q7TMK9
MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTV...
Function: Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRN...
Q7TP47
MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPD...
Function: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Is associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Binds to apoB mRNA AU-rich sequences. Part of the APO...
Q00839
MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDDEEAGGRPAMEPGNGSLDLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEGGGGGGRPGAPAAGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLW...
Function: DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression . Plays a role in the regulation of interphase la...
Q0QLF7
MFKIDEEKCKKCRMCVKECPVHAVYYEKKDKGAIVEITEKCVECGICKRVCKFGAIENDAPLESVITCSSCPIQCKVPLGETGACTRYRNVGGKLVRDRELVVEALEQKEAADNIKKPIITAVGAGTNYPCSKPAPHIVSECRDGVDVVTVVTEAPLSYSGLVIKLDTNTYIGEEGDPVYRDGKVVGMVNTEEYGSKMIAIGGANRLTGDNGFATARTIVELANGEEVELKVNKKIVLKLKAGVAPVIDGVEESIMRIGCGSATVGLFAKRMKDAVDECIVIDHHVIGLCSEHLAGEAVGMTWSGIIPNATKSSRGRYFG...
Cofactor: Binds 1 flavin covalently per subunit. Function: Catalyzes the reversible reduction of 6-hydroxynicotinate to 6-oxo-1,4,5,6-tetrahydronicotinate. Catalytic Activity: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] Sequence Ma...
D8LQS7
MQRVGAASPTCSSLQAPAAAPPILTISPHHRVKTAETAAEPDLLEPTGVHHPFHSLSPLTEARAWAAREGQYFNGLIEANGGASVSKGHPDLAVTFLTDHASCEWFFSQRQEVLDRQDGAYFGPLKCKKQYIGESLPTLASNQKESHQVLREHKLRVFRSRVPFAQSAMTNATDTFYKNLRDNGTGDYTVVYDFFLQQTIHFLHEWIYGLGVEGGQPLPPFKDFMNANPLDVSVLLELEMDTPVANLAAKLAQRSKKPSAEQLASVESIAEAIRSSDVWAGFVEMLEDSNVNTKDLERSFMFTTNFQSAGAIAKGMMPVV...
Function: Cytochrome P450 hydroperoxide bicyclase involved in the metabolism of oxylipins 'ectocarpins' natural products, such as hybridalactone, ecklonilactones and derivatives . Isomerizes the hydroperoxides into epoxyalcohols via epoxyallylic radical . Can use alpha-linolenic acid 13(S)-hydroperoxide (13-HPOTE) and ...
Q8GZ99
MSSRTGASLLLILFFFQICSVSALTNGLDASALNALKSEWTTPPDGWEGSDPCGTNWVGITCQNDRVVSISLGNLDLEGKLPADISFLSELRILDLSYNPKLSGPLPPNIGNLGKLRNLILVGCSFSGQIPESIGTLKELIYLSLNLNKFSGTIPPSIGLLSKLYWFDIADNQIEGELPVSNGTSAPGLDMLLQTKHFHFGKNKLSGNIPKELFSSNMSLIHVLFDGNQFTGEIPETLSLVKTLTVLRLDRNKLIGDIPSYLNNLTNLNELYLANNRFTGTLPNLTSLTSLYTLDVSNNTLDFSPIPSWISSLPSLSTLR...
Function: Leucine-rich repeat receptor protein kinase that acts as sensor of extracellular hydrogen peroxide . Required for intracellular calcium influx in response to extracellular hydrogen peroxide . Mediates hydrogen peroxide-induced activation of calcium channels in guard cells and is required for stomatal closure ...
A9A2G6
MAAVKKIFDEIIETDHKVITEESSKSILKNYGVKVPPYALVTSAEEAAKEAKKIGFPLVMKVVSPQILHKTDVGGVKVGLDNVADVKKTFTDMYGRLSKKKGVNVKGILLEKMVPKGVELIVGIQNDSQFGPIIMVGMGGIMTEVMKDVAFRMLPITTSDAKSMLNELKGSKLLKGFRGSEPIDTNLVAKMLVNIGKLGVENADYINSIDFNPVIVYPKSHYVVDAKIILNKEKKKNSISKAKPSITDMETFFTPKSVALVGASASPGKIGNSILDSLVNYDFKGKVYPINPKADKIFGQKCYPSVADIPGKVDLVVVSV...
Cofactor: No activity with Ni(2+), Co(2+) and Ca(2+). Function: Involved in thaumarchaeal hydroxypropionate/hydroxybutyrate (HP/HB) cycle, a modified version of the autotrophic HP/HB cycle of Crenarchaeota. Catalyzes the formation of 3-hydroxypropionyl-CoA, ADP and phosphate from 3-hydroxypropionate, coenzyme A (CoA) a...
A4YGR1
MFMRYIMVEEQTLKTGSQELEEKADYNMRYYAHLMKLSKEKPAEFWGSLAQDLLDWYEPWKETMRQEDPMTRWFIGGKINASYNAVDRHLNGPRKFKAAVIWESELGERKIVTYQDMFYEVNRWANALRSLGVGKGDRVTIYMPLTPEGIAAMLASARIGAIHSVIFAGFGSQAIADRVEDAKAKVVITADAYPRRGKVVELKKTVDEALNSLGERSPVQHVLVYRRMKTDVNMKEGRDVFFDEVGKYRYVEPERMDSNDPLFILYTSGTTGKPKGIMHSTGGYLTGTAVMLLWSYGLSQENDVLFNTSDIGWIVGHSYI...
Function: Plays a role in the autotrophic CO(2) fixation pathway. Activates 3-hydroxypropionate to its CoA ester. Can also activate propionate, and to a lesser extent acrylate, acetate and butyrate. Catalytic Activity: 3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate Sequence Mass (Da): 7440...
P84074
MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF
Function: Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels . May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). PTM: Myristoylation facilitates association with membranes. Location T...
Q05353
MGKLALAAKITHVPSMYLSELPGKNHGCRQGAIDGHKEISKRCREMGVDTIIVFDTHWLVNSAYHINCADHFEGVYTSNELPHFIRDMTYNYEGNPELGQLIADEALKLGVRAKAHNIPSLKLEYGSVVPMRYMNEDKRFKVVSISAFCTVHDFADSRKLGERIVKAIEQYDGTVAVLASGSLSHRFIDDQRAEEGMNSYTREFDRQMDERVVKLWREGQFKEFCNMLPEYADYCYGEGNMHDTVMLLGMLGWDKYDGKVWSLSPSYSQASWHRSG
Function: Transforms homoprotocatechuic acid (HPC) into 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS). Catalytic Activity: 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+) Sequence Mass (Da): 31495 Sequence Length: 276 Pathway: Aromatic compound metabolism; 4-hydroxyphenyl...
P42269
MKKVNHWINGKNVAGNDYFLTTNPATGEVLADVASGGEAEINQAVATAKEAFPKWANLPMKERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGITAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKKYSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKFAERANRVRVGDPTDPNTQVGALI...
Function: Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM). Sequence Mass (Da): 50827 Sequence Length: 468 Pathway: Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 3/...
Q05354
MPHFIVECSDNIREEADLPGLFAKVNPTLAATGIFPLAGIRSRVHWVDTWQMADGQHDYASVHMTLKIGAGRSLESRQQAGEMLFELIKTHFAALMESRLLALSFEIEELHPTLNFKQNNVHALFK
Function: Transforms 5-carboxymethyl-2-hydroxy-muconic acid (CHM) into 5-oxo-pent-3-ene-1,2,5-tricarboxylic acid (OPET). Catalytic Activity: (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate Sequence Mass (Da): 14215 Sequence Length: 126 Pathway: Aromatic compound metabolis...
A4YI89
MEFETIETKKEGNLFWITLNRPDKLNALNAKLLEELDRAVSQAESDPEIRVIIITGKGKAFCAGADITQFNQLTPAEAWKFSKKGREIMDKIEALSKPTIAMINGYALGGGLELALACDIRIAAEEAQLGLPEINLGIYPGYGGTQRLTRVIGKGRALEMMMTGDRIPGKDAEKYGLVNRVVPLANLEQETRKLAEKIAKKSPISLALIKEVVNRGLDSPLLSGLALESVGWGVVFSTEDKKEGVSAFLEKREPTFKGK
Function: Plays a role in autotrophic carbon fixation via the 3-hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl-CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crotonyl-CoA. Inactive towards (R)-3-hydroxybutyryl-CoA. Cata...
P32755
MTTYSNKGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGRKKSQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEEL...
Cofactor: Binds 1 Fe cation per subunit. Function: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Location Topology: Peripheral membrane protein Sequence Mass (Da): 45112 Se...
Q53586
MTQTTHHTPDTARQADPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMQLVAYSGPENGSRETASYVLTNGSARFVLTSVIKPATPWGHFLADHVAEHGDGVVDLAIEVPDARAAHAYAIEHGARSVAEPYELKDEHGTVVLAAIATYGKTRHTLVDRTGYDGPYLPGYVAAAPIVEPPAHRTFQAIDHCVGNVELGRMNEWVGFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKVKFPINEPALAKKKSQIDEYLEFYGGAGVQHIALNTGDIVETVRTMRAAGVQFLDTPDSYYDTLGEWVGDTRVPVDTLREL...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 41863 Sequence Length: 381 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. EC: 1.13.11.27
Q27203
MSENKDHVVVGYTEKPVGERPTGGKFLGYDHLHFWVGNAKQAAGWYTSRFGFEYYAYKGLETGSREVATHVVRNKQGVTLAFSTPYGNDKDNQREMNQHQSLHGDGVKDVAFAVEDCHSIYNKAIQRGAKCAYPPQDLKDEHGSVTIAAVHTYGEVIHTFIQRNDYKGFFMPGFVAHPLKDPLNNVLPDISYNYVDHIVGNQPDNMMTSAADWYEKTLDFHRFWSVDDSMIHTEFSSLRSIVMTDYDQKIKMPINEPADGKRKSQIQEYIDFYAGPGVQHIALNTSDVINTVEGLRARGVEFLSIPTSYYDNLRKALTAQ...
Cofactor: Binds 1 Fe cation per subunit. Function: Key enzyme in the degradation of tyrosine. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 46046 Sequence Length: 404 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylala...
O42764
MAPGALLVTSQNGRTSPLYDSDGYVPAPAALVVGGEVNYRGYHHAEWWVGNAKQVAQFYITRMGFEPVAHKGLETGSRFFASHVVQNNGVRFVFTSPVRSSARQTLKAAPLADQARLDEMYDHLDKHGDGVKDVAFEVDDVLAVYENAVANGAESVSSPHTDSCDEGDVISAAIKTYGDTTHTFIQRTTYTGPFLPGYRSCTTVDSANKFLPPVNLEAIDHCVGNQDWDEMSDACDFYERCLGFHRFWSVDDKDICTEFSALKSIVMSSPNQVVKMPINEPAHGKKKSQIEEYVDFYNGPGVQHIALRTPNIIEAVSNLR...
Cofactor: Binds 1 Fe cation per subunit. Catalytic Activity: 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate Sequence Mass (Da): 46740 Sequence Length: 419 Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. EC: 1.13.11.27
Q9JN69
MDVRTLAVGKAHLEALLATRKMTLEHLQDVRHDATQVYFDGLEHLQNVAQYLAIPLSEFFVGQTQSDLDDGVKIARRNGGFKREEIRGGVHYYTYEHLVTTNQDPGLMALRLDLHSDDEQPLRLNGGHGSREIVYVTRGAVRVRWVGDNDELKEDVLNEGDSIFILPNVPHSFTNHVGGAKSEIIAINYG
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic. Catalytic Activity: (S)-2-hydroxypropylphosphonate + H2O2 = (1R,...
Q56185
MSNTKTASTGFAELLKDRREQVKMDHAALASLLGETPETVAAWENGEGGELTLTQLGRIAHVLGTSIGALTPPAGNDLDDGVIIQMPDERPILKGVRDNVDYYVYNCLVRTKRAPSLVPLVVDVLTDNPDDAKFNSGHAGNEFLFVLEGEIHMKWGDKENPKEALLPTGASMFVEEHVPHAFTAAKGTGSAKLIAVNF
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic. Catalytic Activity: (S)-2-hydroxypropylphosphonate + H2O2 = (1R,...
O66550
MATVYLGLGSNVGDRISYILKAIEKLEEFLEIEKISTVYESKAWGFENQGNFLNFVLKAKTSLLPQELLLKIKKVEKEVGRKERFKWGPREIDIDILLYKDEVIRTKLLKVPHPFLEKRDFFVYPLLEIEPNVIHPIYRKPLKEFKPENTLKPFCCILKV
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 18838 Sequ...
P29252
MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLFNRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVDEFVHSES
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 19058 Sequ...
Q9PJ54
MLKIQGVKHFEKSRFFPFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKILSTSPMLINEAFGFKEQKDFTNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKNAPRTLDLDLLYFSQKVKRDKWCEVPHKGAKERVSVILPLGMI
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 18628 Sequ...
P26281
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 18079 Sequ...
P43777
MITAYIALGSNLNTPVEQLHAALKAISQLSNTHLVTTSSFYKSKPLGPQDQPDYVNAVAKIETELSPLKLLDELQRIENEQGRVRLRRWGERTLDLDILLYGNEIIQNERLTIPHYDMHNREFVIVPLFEIASDLVLPNSQIITELVKQFADHKMIKLNP
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 18299 Sequ...
O25680
MMREILTSRFFPSLFKKRLDFSNRVVLGLGSNLKNPLKILKNCFLYFKNHSKIGKIFSSPIYINPPFGYTKQPNFYNATIILKTSLSLRHFFALVFYIERRFGRQRKRDFKDAPRTLDIDIIAFNQVILRQNDLALPHPKWSERDSVLVPLALQQILFKKGEW
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 19282 Sequ...
P71512
MTRAYLGLGSNIGDKAAMLAGAVEHLAATPGIRVVARSADYRTPPWGDTDQDWFLNAAVAIDTELTPHGLLEVCLSIEAALGRVRERRWGPRVIDIDVLAYEGAQVSDERLVLPHRFVRERAFVLVPLAEIAPDLVIGGETVREALAKLDPSGIERVE
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 17206 Sequ...
O69528
MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSFLNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQTSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRAQRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD
Function: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. Catalytic Activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) Sequence Mass (Da): 20761 Sequ...
P61325
MEKFTIKDLTDNLKFEIISGQDKLDTEIKSYGINRAGLELADYFKPFKDQSEWRATLMSTKESGYMLQFDEETKIKKYTQLMKCGIPVLIITNKFKDKTLIKVAKRLNFPLLRSDYPITIQLVQKIQDIYDIYFSPTAEEHAALMNIFGTGVLIKGKSGIGKSELCLDLIKHNHLFIGDDRIILTNKSNKIIGRVHPILKNLIEIRGIGIFDIVKSNGYQVIMNESPVELVVELVEYKEQNIDNSDRLGNDWSKFKILGVEIEHIQIPVSAGRSLVNIIESAVAQFKINKSKQFENVFDVIHKRTKEFLSSKK
Function: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation...
P75548
MKKLLVKELIEQFQDCVNLIDGHTNTSNVIRVPGLKRVVFEMLGLFSSQIGSVAILGKREFGFLSQKTLVEQQQILHNLLKLNPPAIILTKSFTDPTVLLQVNQTYQVPILKTDFFSTELSFTVETYINEQFATVAQIHGVLLEVFGVGVLLTGRSGIGKSECALDLINKNHLFVGDDAIEIYRLGNRLFGRAQEVAKKFMEIRGLGIINVERFYGLQITKQRTEIQLMVNLLSLEKQTTVTFERLGTELKKQRLLGVDLSFYEIPISPGRKTSEIIESAVIDFKLKHSGYNSALDFIENQKAILKRKKDES
Function: Is a metabolite-sensitive enzyme that catalyzes the ATP-as well as probably the pyrophosphate-dependent phosphorylation of Ser-47 in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-...
Q98PL1
MKKKLFVSELIKHFDLEVLNHDFPEIEDREILTPSIKRLGLELSGHFIYDAISGVIVGWGTNESKFFEKIGSEKAKSSIEEIFSRKIPMLVLSKGFDKNYYSTIIEIANKHKTPVIFYKASLSEINTILGIYLLQYFAKKVQVHGTLVSVFGMGILIVGDSGLGKSEAALELVQKGHVLISDDAVLVSHYGNKYFGKAPYITKNLIEVRGLGLIDILSVHGLKSVLPECEINFVVELKDYEQNKSNFDRLGNKVLKYQIGEWKIPKIEIPIRQGRSVASLIEASANMFLSKLNGHDVLAMIQERSLNDE
Function: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation...
Q9K081
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQHNEDRPD
Function: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation...
Q82Y30
MSQVSITQLFEENQEKLNLQWGEPSAVIDRQLENHQINNSTQELIGHLNFVHPNWIQVLNQTSVNYLDQLDDVSLKKRLNQLAKSQLACLIVADDAPIPNAIRQFVNEQSVPLIQSATASLEIIWRLQSYLARMLAPAITRHGVLLDVLGMGVMITGESGVGKSELALELISRGHGLVADDVVELHRIGPETLEGQCPPLLRDFLEVRGLGMLNIRTIFGETAVRRRKNMKLIVHLEKTVGSSINAYERLPLSNLNEIILNVGIRKVIIPVAAGRNLAVLVEAAVRNYILQLRGIDSTQEFIRRHESEMAGNTAEHFDDS...
Function: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation...
Q8Y2D1
MELTGVTAQSIFDDNAADLKLSWVAGLEGADRAFDVDFAKEATSAADLVGHLNLIHPNRIQVLGKPEITYYQRLSEENRKRQMGELILLEPPFLVVADGVDPPPDLELRCTRSSTPLFTSPISSAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKIKLIVQLVRRNDGEFERLPLDSQYMDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRDFMDRQRAAMQAEAASHSPQ...
Function: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation...
O85093
MSALRLRKVDALLAQATRELGAGQSLGFSAAGQDAELTLLPLLADAGEPAGAVWLSTAIGPLLLSDAEALLSLLGDIPLTLGGEQQAWYWQLFNQRLSPTVARLLAPVEPLHNKPQAPTLGCRVQIRRGGEQLHAHMHATPDTLLRLLRSASWQARTRTVDESWSVASPLIIGEMSLTREQIASLRPGDVVLPAHCQFDSAGQGFLSLAGRQWAAQTDQHAQRLFLRLSHEEHRHHEY
Function: Component of the type III secretion system, which is required for effector protein delivery, parasitism, and pathogenicity. Probably participates in the formation of a C-ring-like assembly along with hrcQb. Location Topology: Peripheral membrane protein Sequence Mass (Da): 25998 Sequence Length: 238 Domain: T...
Q4L8L8
MNLAWKEIKFYRFRYTLIMLIIFLLGSMVLFISGLAQGLARENISYLNNMPAEHYIVEDNKEPKLESSQLNQSQQNKIEKIIHENATQMGTQTLKINQQDQDVITLNTPKHLTPKLVSGNYPKKQNEIAISEKLTGNDLKVGDTVTFKGHHHNYKISGIMNESMYSHSSMILMNKEAFKSLNKQVSTFYPVDKINKDNKESLKQIKGIKVVNEKALTDNIASYQAEQMPLNLMIISLFVITAIVLSAFFYVMTIQKIPQIGILKAIGIKTKHLLTALLLQIILTTMVGVILAFSVILILNAFMPVTMPFYLSYSQVLLMI...
Function: Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 39569 Sequence Length: 351 Subcellular Location: Cell membrane
Q49ZT7
MKLAWQEIKYYKFRYILIMLIILLLGIMVLFISGLAQGLARENISMLDNMKSEKYVLQDNKQPQIEKSIIKPEQQNKIEDITGQEPLKMAPQTLKIDKNEEDVLMINTVKNEKPELKAGHYPTKDNEVAINNKLTADGINVGDKIKLKDGKALKVSGVLNDTMYSHSSVVMMSDNGFNTLNKQASTIYPVKDLSKSEQEKVNDISGVKVFTENDITSEIPSYQAEQAPLNMMIVSLFVISAIVLSAFFYVMTIQKIPEIGILKAIGMKTKHLLSALIIQILITTMIGVIISVAIITGLSFLMPVSMPFHVTTSNLLLVVG...
Function: Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 38790 Sequence Length: 350 Subcellular Location: Cell membrane
O94641
MADYPFTDKAAKTLSDAYSIAQSYGHSQLTPIHIAAALLSDSDSNGTTLLRTIVDKAGGDGQKFERSVTSRLVRLPAQDPPPEQVTLSPESAKLLRNAHELQKTQKDSYIAQDHFIAVFTKDDTLKSLLAEAGVTPKAFEFAVNNVRGNKRIDSKNAEEGFDALNKFTVDLTELARNGQLDPVIGREDEIRRTIRVLSRRTKNNPVLIGEPGVGKTSIAEGLARRIIDDDVPANLSNCKLLSLDVGSLVAGSKFRGEFEERIKSVLKEVEESETPIILFVDEMHLLMGAGSGGEGGMDAANLLKPMLARGKLHCIGATTL...
Function: Required, in concert with Hsp40 and Hsp70 and small Hsps, for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel o...
P31539
MNDQTQFTERALTILTLAQKLASDHQHPQLQPIHILAAFIETPEDGSVPYLQNLIEKGRYDYDLFKKVVNRNLVRIPQQQPAPAEITPSYALGKVLQDAAKIQKQQKDSFIAQDHILFALFNDSSIQQIFKEAQVDIEAIKQQALELRGNTRIDSRGADTNTPLEYLSKYAIDMTEQARQGKLDPVIGREEEIRSTIRVLARRIKSNPCLIGEPGIGKTAIIEGVAQRIIDDDVPTILQGAKLFSLDLAALTAGAKYKGDFEERFKGVLKEIEESKTLIVLFIDEIHMLMGNGKDDAANILKPALSRGQLKVIGATTNNE...
Function: Required, in concert with Hsp40 (YDJ1) and Hsp70 (SSA1) and small Hsps (HSP26), for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process throu...
Q92598
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVP...
Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release . Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits...
Q61699
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVP...
Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease mar...
Q9S7U5
MVKSTDGGGGSSSSSSVAPFLRKCYDMVDDSTTDSIISWSPSADNSFVILDTTVFSVQLLPKYFKHSNFSSFIRQLNIYGFRKVDADRWEFANDGFVRGQKDLLKNVIRRKNVQSSEQSKHESTSTTYAQEKSGLWKEVDILKGDKQVLAQELIKVRQYQEVTDTKMLHLEDRVQGMEESQQEMLSFLVMVMKNPSLLVQLLQPKEKNTWRKAGEGAKIVEEVTDEGESNSYGLPLVTYQPPSDNNGTAKSNSNDVNDFLRNADMLKFCLDENHVPLIIPDLYDDGAWEKLLLLSPSRKKTKKQENIVKKGKDDLTLEEE...
Function: Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 42630 Sequence Length: 374 Domain: The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domai...
Q9LVW2
MTAIPNVVDIESSSSSLCQETATETVTVERGSSDSSSKPDDVVLLIKEEEDDAVNLSLGFWKLHEIGLITPFLRKTFEIVDDKVTDPVVSWSPTRKSFIIWDSYEFSENLLPKYFKHKNFSSFIRQLNSYGFKKVDSDRWEFANEGFQGGKKHLLKNIKRRSKNTKCCNKEASTTTTETEVESLKEEQSPMRLEMLKLKQQQEESQHQMVTVQEKIHGVDTEQQHMLSFFAKLAKDQRFVERLVKKRKMKIQRELEAAEFVKKLKLLQDQETQKNLLDVEREFMAMAATEHNPEPDILVNNQSGNTRCQLNSEDLLVDGG...
Function: Seed-specific transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Seems to be specialized for the developmental expression of heat shock protein (HSP) genes during seed maturation. Activated by ABI3. PTM: Exhibits temperature-dependent p...
Q10PR4
MGSKKRSPQHPAAAAPPPAVGGGGGGEVSGDGGASTANGPVVPKPSEVAPFLTKVYDMVSDPATDNVISWAEGGGSFVIWDSHAFERDLHRHFKHSNFTSFIRQLNTYGFRKVHPDRWEWANEGFIMGQKHLLKTIKRRKKSSQESPSEIQKAPVKTAPGTENIEIGKYGGLEKEVETLKRDKALLMQQLVDLRHYQQTSNLEVQNLIERLQVMEQNQQQMMALLAIVVQNPSFLNQLVQQQQQQRRSNWWSPDGSKKRRFHALEQGPVTDQETSGRGAHIVEYLPPVPETSGQVNPVEGAICSANSQPVPSPAVATPMD...
Function: Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE). PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 45466 Sequence Length: 410 Domain: The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. Subcellular Location: Cytopla...
Q96320
MTAVTAAQRSVPAPFLSKTYQLVDDHSTDDVVSWNEEGTAFVVWKTAEFAKDLLPQYFKHNNFSSFIRQLNTYGFRKTVPDKWEFANDYFRRGGEDLLTDIRRRKSVIASTAGKCVVVGSPSESNSGGGDDHGSSSTSSPGSSKNPGSVENMVADLSGENEKLKRENNNLSSELAAAKKQRDELVTFLTGHLKVRPEQIDKMIKGGKFKPVESDEESECEGCDGGGGAEEGVGEGLKLFGVWLKGERKKRDRDEKNYVVSGSRMTEIKNVDFHAPLWKSSKVCN
Function: Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 31328 Sequence Length: 284 Domain: The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domai...
Q67TP9
MAAAEAAAAVGKQQQKGGGGRGGGGGGPAPFLTKTNQMVEESATDEVISWGKEGRSFVVWKPVEFARDLLPLHFKHCNFSSFVRQLNTYGFRKVVPDRWEFANGNFRRGEQGLLSGIRRRKATTPQSSKSCGSGVNVAFPPPLPPLPPEPSATTSSGNDRSSSSASSPPRADITSENEQLRKDNQTLTMELARARRHCEELLGFLSRFLDVRQLDLRLLMQEDMRAAAGGVGGEQRVQEHAREEKCVKLFGVLLDDTHGAATRKRARCEEAAASERPIKMIRIGEPWVSVPSSGPARCGGDN
Function: Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE). PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 32799 Sequence Length: 302 Domain: The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. Subcellular Location: Cytopla...
O22230
MEDAGEHLRCNDNVNDEERLPLEFMIGNSTSTAELQPPPPFLVKTYKVVEDPTTDGVISWNEYGTGFVVWQPAEFARDLLPTLFKHCNFSSFVRQLNTYGFRKVTTIRWEFSNEMFRKGQRELMSNIRRRKSQHWSHNKSNHQVVPTTTMVNQEGHQRIGIDHHHEDQQSSATSSSFVYTALLDENKCLKNENELLSCELGKTKKKCKQLMELVERYRGEDEDATDESDDEEDEGLKLFGVKLE
Function: Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 28308 Sequence Length: 244 Domain: The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domai...
Q9C635
MAMMVENSYGGYGGGGGERIQLMVEGQGKAVPAPFLTKTYQLVDDPATDHVVSWGDDDTTFVVWRPPEFARDLLPNYFKHNNFSSFVRQLNTYGFRKIVPDRWEFANEFFKRGEKHLLCEIHRRKTSQMIPQQHSPFMSHHHAPPQIPFSGGSFFPLPPPRVTTPEEDHYWCDDSPPSRPRVIPQQIDTAAQVTALSEDNERLRRSNTVLMSELAHMKKLYNDIIYFVQNHVKPVAPSNNSSYLSSFLQKQQQQQPPTLDYYNTATVNATNLNALNSSPPTSQSSITVLEDDHTNHHDQSNMRKTKLFGVSLPSSKKRSH...
Function: Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 39615 Sequence Length: 348 Domain: The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domai...
Q9LV52
MEDDNSNNNNNNNVIAPFIVKTYQMVNDPSTDWLITWGPAHNSFIVVDPLDFSQRILPAYFKHNNFSSFVRQLNTYGFRKVDPDRWEFANEHFLRGQKHLLNNIARRKHARGMYGQDLEDGEIVREIERLKEEQRELEAEIQRMNRRIEATEKRPEQMMAFLYKVVEDPDLLPRMMLEKERTKQQQQVSDKKKRRVTMSTVKSEEEEVEEDEGRVFRVMSSSTPSPSSTENLYRNHSPDGWIVPMTQGQFGSYETGLVAKSMLSNSTSSTSSSLTSTFSLPESVNGGGGGGCGSIQGERRYKETATFGGVVESNPPTTPP...
Function: Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 37714 Sequence Length: 330 Domain: The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domai...
Q5AQ33
MIMNMTTDYRDPLLDLFGTESNSGNETSSPSDIPVINRSGTFNQQQFSPLLTQQSLYNTPNSGSTPNIFDPNYTQMQEEQTSPSSNKLQPEDPPRKKRNTRSQTKIHQQSEGDEYNSNDYKDSIDLDKPPVVEPSPPFFVESDTTPEFVIPTPTSEQQQQQHHELIAQDYQRSNNSNQFGNLTHYEPNLPPLPPLSESILPQTNTFHPLVLPHDPRHAITAGPANNSQQQQQQQQQDSSIPSDGISSKIQQLHAPSLSNNQSASQRKKKESSGPKTRPAFVMKIWSMVNDPANHEYIRWNDDGKTFQVFHREDFMKVILP...
Function: DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. With HSP90, is required for the modulation of the chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions. Activated ...
J9VHZ9
MTTNLYAIAGPSKPTTPTSTPSPRSEPPSPLKSLTSLPTNPLNPQGTSTSNALTNQSSSTGIGISKPGLSVDENGEVMKVPAFLNKLYTMVSDPEVDDLIYWGENGDSFFVPNAELFGRELLPRWFKHSNFSSFVRQLNMYGFHKVPHLQSGALKNETPIELWEFANPYFKRGQPQLLTKVTRKNNRLSNSGVGSSSSLGGSGAGGGMNTRSASAAAASGSGSGQIQQAISQGHEAGNHSTSGKYLITDGTTPGSAPPSHTSAGPLIAPQTLDLSAINSGIAAIRQTQASIATDLRKLQASNEALWRQAYETQEKQRKHE...
Function: DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription . Promotes thermotolerance by transiently regulating a subset of genes . Induces expression of STI, SSA1, SSA2, HSP78 and KAR2 during the heat response . PTM: Phosphorylated at high temperat...
P22813
MSRSRSSAKAVQFKHESEEEEEDEEEQLPSRRMHSYGDAAAIGSGVPAFLAKLWRLVDDADTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFHKITSIDNGGLRFDRDEIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTDVKVMRGRQDNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQLMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSPPAVERPRSNMSISSHNVDYS...
Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 76933 Sequence Length: 691 Subcellular ...
P22121
MGHNDSVETMDEISNPNNILLPHDGTGLDATGISGSQEPYGMVDVLNPDSLKDDSNVDEPLIEDIVNPSLDPEGVVSAEPSNEVGTPLLQQPISLDHVITRPASAGGVYSIGNSSTSSAAKLSDGDLTNATDPLLNNAHGHGQPSSESQSHSNGYHKQGQSQQPLLSLNKRKLLAKAHVDKHHSKKKLSTTRARPAFVNKLWSMVNDKSNEKFIHWSTSGESIVVPNRERFVQEVLPKYFKHSNFASFVRQLNMYGWHKVQDVKSGSMLSNNDSRWEFENENFKRGKEYLLENIVRQKSNTNILGGTTNAEVDIHILLNE...
Function: DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. PTM: Exhibits temperature-dependent phosphorylation. Sequence Mass (Da): 75420 Sequence Length: 677 Subcellular Location: Nucleus
Q8YAC4
MSDYLVKALAYDGMARVYAAVTTETIKEAQRRHDTWSVSSAALGRTMTGTLFLGAMQKEDQKITVKIEGDGPIGPIVADSNAQGQIRGYVTNPHVHFSELNEAGKLDVRRGVGTSGMLSVVKDLGFGENFTGQTPIVSGEIGEDFTYYLATSEQINSSVGVGVLVNPDDTIEAAGGFMLQLLPGATDEIIDEIEKNLMALPTVSRMIEAGETPESILAKLAGGEDKLQILEKIPVSFECNCSKERFGSAIISLGKEEIRSMIEEDHGAEAECHFCRNTYDFSEEELKTLYEEAK
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q1H2B1
MQISDHLHRFLFENTPVRGSIVHLDDSFQQSLQHHDFPQILRQALGELMAASALLAATLKLKGGALVLQVQGKGPLKLLVVECTSDLGIRATAKWSGELDGMSFSDMVSNGHFVITLDPRDGGQPYQGIVPVEGGSIAEILQSYMQRSEQIDTRMWLACDGKRAAGMLVQKMPDQPDAADPDAWNRIIMLADTVRDEELLDLSAVSLIKRLFNEEDVRLFKEQPIKFHCGCSRESVGNMLRMLGEEEVADILAEQHTIDINCDFCNAEYHFDEVDAEQLFTTEIVMPGNDVRH
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q9JWC8
MNQTAINRADVRTRFIFDDMPVRGLHVRLENVWQHIVKQKNYPAAIRRALGELLAAGVLLSGNLKNEGTLIVQVQGQGRLKMLVAEATSDRTVRATARWDETAEIADDESLGDLLGEGGVFVLTLQPKDGEPWQGVVPLEGDGIAQMLVNYMKRSEQLDTHIVLSASDEAAGGLLVQRLPEEVLDEEAWEHVSTLARTLTAEELAGLDAQHVLYRLFHETPPRVFEPETFEFSCTCSRGKVSDMLLMLGGEEVGGVVVEQGSIEVDCDFCHSKYVFDETDVNALFGEDVVGVAKGLPRHTVQ
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
Q3J9G2
MNNRDNLHRFLFEEAKIRGELVQLDASWRAVLACHDYPAVVQSQLGQALAATILLSATIKFKGSLILQTQSEGPLQTLVAQATHHRTLRGLARWDGDVPHGSLSETYGSGRLALTIQTEGKNPYQGIVSLEGVNLAEALQTYFSRSEQLRTRLWLVADEQQAVGLFLQELPSQQGHKTDWERIALLASTVTTQEMLSLPSTELLYRLFNEEQVRLFEPEPVSFRCGCSRGRIEQTLAALGREEMESILKEQGIIEVDCEFCNRHYNFDRVDMEQLFTEQVKAPVTSTRH
Function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. PTM: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteine...
P57115
MTTILSVRLKNKVVIGGDGQATLGNTIMKSNVKKIRSLYHEKVIAGFAGGTADAFTLFEMFDKKLAMYQGQLQRAAIELAKDWRSDRMLRKLEALLAVADKKTSLIITGNGDVIQPEDDLIAIGSGGSYAQSSARALIENTHLDANQIVRKSLNIAANICIYTNHNFTIKELFSEK
Function: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Catalytic Activity: ATP-dependent cleavage of peptide bonds with broad specificity. Sequence Mass (Da): 19317 Sequence Length: 176 Subcellular Location: Cytoplasm EC: 3.4.25.2
Q9ZDK9
MSDNFALHGTTILCLKKKEEIIIAADGQVSHGNTVLKSTARKLRTIANNKIIVGFAGSTADGLALFEKLEIKIEQYNSNLLRSAVELAKDWRNDKYLRRLEAMMIVADRSHILILTGNGDVIEPENNVAAIGSGGLFALSAARALMSYENNLTAEEIALKSMNIAADLCVFSNHNIIMEKVV
Function: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Catalytic Activity: ATP-dependent cleavage of peptide bonds with broad specificity. Sequence Mass (Da): 19873 Sequence Length: 182 Subcellular Location: Cytoplasm EC: 3.4.25.2
Q28222
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEADLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTRTIAYALDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTTWVEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALR...
Function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in th...