ids
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O35386
MNLTRAGARLQVLLGHLGRPSAPTIVAQPVSGLASPASFQPEQFQYTLDNNVLTLEQRKFYEENGFLVIKNLVSDDDIQRFRAEFERICREEVKPPGIVIMRDVALAKQDYMPSDRMVSKIQDFQEDEELFRYCLLPEILKYVECFTGPNIMALHGMLINKPPDVGKKTSRHPLHQDLHYFPFRPSNLIVCAWTAMEHIDRNNGCLVVLPGTHKGTLKPHDYPKWEGGVNKMYHGIQDYDPNSPRVHLVMEKGDTVFFHPLLIHGSGRNKTQGFRKAISCHFGSSDCQCIDVSGTSQENIAREVVEMAEKKYGFQGVMDF...
Function: Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon at...
P0DJQ3
MERIDSHVSPRYAQIPTFMRLPHDPQPRGYDVVVIGAPYDGGTSYRPGARFGPQAIRSESGLIHGVGIDRGPGTFDLINCVDAGDINLTPFDMNIAIDTAQSHLSGLLKANAAFLMIGGDHSLTVAALRAVAEQHGPLAVVHLDAHSDTNPAFYGGRYHHGTPFRHGIDEKLIDPAAMVQIGIRGHNPKPDSLDYARGHGVRVVTADEFGELGVGGTADLIREKVGQRPVYVSVDIDVVDPAFAPGTGTPAPGGLLSREVLALLRCVGDLKPVGFDVMEVSPLYDHGGITSILATEIGAELLYQYARAHRTQL
Cofactor: Binds 2 manganese ions per subunit. Catalytic Activity: amidinoproclavaminate + H2O = proclavaminate + urea Sequence Mass (Da): 33401 Sequence Length: 313 Pathway: Antibiotic biosynthesis; clavulanate biosynthesis; clavulanate from D-glyceraldehyde 3-phosphate and L-arginine: step 4/8. EC: 3.5.3.22
Q42440
MSTGISTDLHVHFGALNFSKTYKSGLSNRTVSFSRVGYAQNRKLSCSVSNTENVAPKDDERGKDRPLVKMCGITSARDAAMAVEAGADFIGMIIWPHSKRSISLSVAKDISKVAREGGAKPVGVFVEDDENTILRAADSSDLELVQLHGNGSRAAFSRLVRKRRVIYVLNANQDGKLLNEVPEEDCHLADWILVDSATGGSGHGFNWAQFKLPSVRSRNGWLLAGGINPTNVSEALSILQPDGIDVSSGICGTDGIQKDKSKISSFITAVRSVHY
Function: Catalyzes the conversion of 5-phosphoribosylanthranilate to l-(O-carboxyphenylamino)-l-deoxyribulose-5-phosphate, which is the third step of the tryptophan biosynthetic pathway. Catalytic Activity: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate Sequence Mass...
P05121
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTD...
Function: Serine protease inhibitor. Inhibits TMPRSS7 . Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots . As PLAU inhibi...
P05120
MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYEL...
Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. PTM: The signal sequence is not cleaved. Sequence Mass (Da): 46596 Sequence Length: 415 Subcellular Location: Cytoplasm
P12388
MEELSMANTMFALNLLKQIEKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGITTRNPENFSGCDFAQQIQKENYPSAILQAQAGDKIHSAFSSLSSTINTPQGDYLLESANKLFGEKSARFKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKTQILELPHTGNISMLLLLPDEIEDASTGLELLESEINFANFNKWISKDTLDEDDVVVYIPKFKLAQSYEL...
Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival. PTM: The signal sequence is not cleaved. Sequence Mass (Da): 46292 Sequence Length: 415 Subcellular Location: Cytoplasm
P29524
MEELSMANTMFALNLLKQIEQSNSTQNIFISPWSISSTLAIVFLGAQANTEEQMAKVLNFDKIGSYDLTPGNPENFHGCDFAQHIQRDNYPVAILQAQARDKIHSAFSSLSSTINTPRLGDYLLESANKLFGEKSARFKEEYIQRCKKYYSTEPEAVDFLECANEARKKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNTIYFKGRWKTPFQKRLNGLYPFRVNLNESKPVQMMYLREKLNIGYIKDLKTQILELPYIGNISMFLLLPDEIEDSSTGLEMLEREINFDNFNKWISKETLDEDDVLVYIPKFKLAQNYE...
Function: Inhibits urokinase-type plasminogen activator. PTM: The signal sequence is not cleaved. Sequence Mass (Da): 47248 Sequence Length: 416 Subcellular Location: Cytoplasm
Q8LPI9
MSTGISSDLHLHPRALNFSKTSKSGLSNRKVSFSSVGYAQNRKLSCSVSSTENVAPKDDDRGKDRPLVKMCGITSARDAAMAVEAGADFIGMIIWPHSKRSISLSVAKDISQVAREGGAKPVGVFVEDDENTILRAADSSDLELVQLHGNSSRAAFSRLVRERKVIYVLNANEDGKLLNVVPEEDGHLADWILVDSATGGRYLDQLLSFFALSHCNVFLRGTSYTITLVHETVCLSQVTEISRV
Catalytic Activity: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate Sequence Mass (Da): 26525 Sequence Length: 244 Pathway: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. Subcellular Location: Plastid EC: 5.3.1.24
Q6G5H3
MTIHKAVKRITASEIRSRKGQEPIVSLTAYQAYSARIADPYCDLLLVGDSVGMVVHGFETTLPVSLDMMILHGQAVMRGSKRALVVVDMPFGSYEESPEQAFSNASRILAETGCSAVKLEGGVYIAETIDFLCKRGIPVMSHVGLTPQAVNRFGGFKTQGRNESNWQQIEADAAAIEKAGAFAVVVEGVVEPLAVKLTQMLSIPTIGIGASSQCDGQILVMEDMLGYGTWVPKFVRRYGVLEQEMEKAIKSYADDVKSRTFPSDEEIYKLKQKSG
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q6MHI3
MKTILDFHDKKSKKQKISMITCYDYSFARIVADSDIDCILVGDSLAMVMLGHSTTLDVSASVMAHHTAAVVRGAGDKFVIADLPFMSYRKGLTANMTAVEKVMKAGAHAVKLEGAAGNLKLVRHLVDSGVPVMGHLGLTPQSVNQLGGFKVQGRDEKAQKKILEAALQLQDAGAFSVVLECVPSKLAKEITAALEIPTIGIGAGVDCDGQVLVLQDMLGMNQGFKPKFVKTYLDGFNTIKGALNQYHQEVSTEIFPSEKESYS
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q9JZW6
MITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLRDMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAETTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMECVLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQAAVRAYVAEVKAKTFPAAEHIFAD
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q82Y18
MDQSAAKRMTITTLQNACEQGEKIAVLTCYDATFAAVLEEAGVDILLVGDSLGNVVQGKSSTLPVTLDEMIYHVRCVERGTHRVFIMADMPFGTFQVSPQEAFGNAVRLMAAGAQMVKIEGGQHMAETVEFLSCRGIPVCAHIGLMPQFVHQLGGYRVQGKTPNDARQLREDALLLQEAGAAMLLMELIPAVLGEEITRLLSIPTIGIGAGAACSGQVLVLHDMLGISSGTLPRFVRNFMMDADSIQTAVSNYVEAVKLGAFPAYEHTF
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
A9A2T9
MHKSVQDIVNMKKGKKKVSVITGYDYTLASLCDKAGIDVLLVGDSAGMVMLGYENTIPVTMDQMCMFTEAVSRARNNALLVADLPFMSYQASIEDAINNSGKLIKAGADAVKLEGGSIMAETISAIVDVGIPVMGHIGLQPQTTMLSQGYKVQGRTKDSAMQLIQDAKELEEAGVFSIALEMVSHEVAQIISETVSAPTIGIGSGVNCDGQVLVVQDLLGMYDKIKPKFAKRYMNLSEDIVKSLEDYKNDVESNTFPAEENWFSMDPEELKKLREQIGS
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q3JCP9
MGRLTLTKLQKMKRQGEKITMLTAYDASFAALLEAAGVEVLLVGDSLGMVIQGQESTLSVTMDDMVYHCRNVSRGSQCTFILSDMPFMSYATPNQAMDNAARLMREGGAQMVKLEGGRLLGEIVEHLTARGIPVCAHLGLLPQSVHRIGGYRVQGREEISARRIQEDAMILQEAGADMLILECVPARLGSKITDALKIPVISCGAGPYCDGQVLVLYDMLGISPGKSPSFSRNFLEGTSNIPNAIQAYVSAVKKNEFPLLELSY
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
A6Q1X8
MKKRHTVNTIKSAKNSNKLVMITAYDALFAKLFEPIVDMILVGDSLNMVFAGRSDTLSATLDQMIYHANAVCSGAPSAFVVLDMPYGTYINEKEALQNAIRIYKETDVDAVKLEGGKEKADLIKTLCQNGIAVMGHIGLLPQHVRGQGGYKVVREADRLMEDAKALEEAGVFSIIIEGVKPEVAAKVTDAVQVPVIGIGAGKETDGQVLVWSDMLGFFEDFKPKFVKQYLNGAKLVKEAVSQYAKEVKEGSFPSQEFSY
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q72LM0
MRRTVKDFRNAKGQRLVYLTAYDYPTARLAEAAGVDAILVGDSLGMVVLGYPSTVPVTLEEMLHHTKAARRGAPETFLVADLPYLAYATLDRALLAAERLLKEGGADAVKLEGGEEVAEIVRGLVRAGVPVLGHVGLTPQTASQLGGYKLQGRRPEEAERILKGALALEEAGAYGVVLEMVPARLAKEVTERLSVHTVGIGAGPHTDAQVLVFHDVVGLYGDFKPRFVKRYLEAGRLIQEALSRYAQEVREGVFPGEEHSF
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q8DM44
MVRRSVTLPQLQAKKALGEPITMLTAWDYLWARLLDAAGVDVILVGDSLGMVALGYPTTLPVTLDQMIHHAQAVRRGVSHSFLVCDLPFLSYQESPEQALRSAGRLIKEAEVQAVKMEGASPVVQAATRRLVEAGIPVLGHVGLLPQRVHQLGGWRQQGNTPQDAAAILAGALALAEAGVFAVILEHIPAALAQQITAQLKIPTIGIGAGPHCDGQVLVTADVLGLSPQVPPFAKVYADLGTQAIAAIENYCQAVKSRQFP
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q10WG3
MAVTTKQLIQWKQKGRPIVALTAYDYTIAQLLDNAGVDLILVGDSLGMVTLGYETTLPVTLEEMIHHAKAVRRAVKQALMVVDLPFLTYQESPQQAIHSAGRILKETGAQAVKLESGNEAIAQTVKKLTSIGIPVMGHIGLIPQSVHQFGGYPQQGNAPDASARILTEALALAEAGAFALVLEHIKADLAKEITEKVSIPTIGIGAGAYCDGQILVINDVLGLSHWQPPFAKPYVNLRETITQAVKEYSLEVKKRKFPQPPSP
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
B3E5K9
MRKKITIPEILLMKQEGRKVTVLTAYDYPTARLVDAGGVDAILVGDSAGVVFSGHENTLPVTMDEMLYHVKAVVRARPKALVVADMPFMACQSGEIEALKNCGRMLQEGGAEAVKIEGGSNMAPIIRAVTEMDIPVMGHVGLTPQSVHRMGGYKVQGRKDQAERILEDAHAVQEAGAFAVVLEGIPAKLAARITEMLEIPTIGIGAGPACDGQVLVIHDILGLCEKYSPKFVKRYADLAPLITEAARQYVSEVKDGTFPTEEHSFS
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q83GK7
MICMSRKPSPTRRTRIHRFHKGSCGRKLVGLTCYDFSTARVLSDCELDFLLVGDSASGVIYGYENTGSVCLDEIIYLAAGVVRGAPNSFIIVDLPFGTYEKSDELAVETAIEVIKRTGASAVKLEGGARMACRISAIVRAGVPVMGHIGFTPQTINALGGYKIQGRDNADLIYLDAQAVEQAGAFAVVMEMVTEDLAKTITSEIKITTIGVGAGRYTDGQLLVINDLIGLSEKKITFAPRYASIDNTVASCVKLWRKDVLEGNFPQKDHIPA
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
A5CX20
MNIEALKVFKESGEKITCLTAYDASFASVFDACGIDIILVGDSLGNVIQGDKNTLDVSMSDMIYHMQAVAKGTQNALRIADMPYQSYTYAEQTLTNAKRLIMAGAQMVKLEGGCEHEASFRILQGNDISVCGHLGLQPQSVVEIDGYRVQGRGKQGANKIIKNALALASWGVKVIVLECVPAELAKQVSQSVSIPIIGIGAGLDCDGQVLVSYDMLGVHVRHVPRFVKNFLTDNGDVKSAVNAFIKAVKDKSFPSKKYSY
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. Catalytic Activity: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5...
Q2T095
MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQEDIEKLQKENVYVLFAPTERDMYPEPQEYRVQPPHDLGDILEGEFRPGFFTGVCTVVTKLMACVQPRVAVFGKKDYQQLMIVRRMCQQLALPVEIVAAETVRDADGLALSSRNRYLSEAERAEAPELAKTLARVRDAVLDGERDLAAIERRAVAHLSARGWQPDYVSIRRRENLVAPSAAQIEAGDPLVVLTAAKLGATRLIDNLEI
Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Mass (Da): 31400 Sequence Length: 279 Pathway: Cofactor biosynthesis; (R)-pan...
Q1DAN8
MAPAVLKTVADVKDWTAGLRREGHRLALVPTMGFLHEGHLSLIREGRRRADVVAVSIFVNPTQFGPKEDLSRYPRDFEGDVAKCISAGAQAIFAPAGPEVMYPQGYQTYVEVTDVSQGLCGARRPGHFRGVATVVTKLLTLFRPEVALFGEKDYQQLQVIRALNQDLHLGADIVGMPTVREPDGLAMSSRNAYLSPEERQRALALSRGLKAAQALLREGTRESEPLVAAVRRELEAAGLREDYVELVDAERLTPLASVAPGQPARLLVAAFSGTTRLIDNMQLGGEENAGRV
Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Mass (Da): 31778 Sequence Length: 292 Pathway: Cofactor biosynthesis; (R)-pan...
Q82Y17
MEIITDIAPLRARLRHEASVAFVPTMGNLHAGHLSLVRIAQKHASCSVVSIFVNRLQFAPHEDFDRYPRTWSDDCRLLEEQGADIVFMPDEKTLYPVPQEFQLLLPPVADTLEGACRPGFFRGVTTVVLKLFNIVQPHIAVFGEKDYQQLQVVHRMVDQLNLPVEIIAGETVRDEDGLALSSRNNYLDATQRQEAGELAHHLKQIRDSIASGERDFPLLEQLAAEKLSKRGWVVDYVAVRQQHTLLPVAASDSSLVILGAAWLNQTRLIDNFLLTLP
Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Mass (Da): 31131 Sequence Length: 277 Pathway: Cofactor biosynthesis; (R)-pan...
A6Q581
MQIVHTPRELKEARIALKGSVGFVPTMGALHQGHLSLIEKSKEHNDYTIVSVFVNPTQFLPGEDFEKYPRRYEADKKICELAGVDILFMPQPDTIYSEDEVLVKAPHQKGYVLEGHFRPGHFDGVLQVVNKLFHIVLPTRAYFGKKDAQQLYLIQKMVQDFFMDIEIVPCEIVRDNDGLALSSRNVYLSDAERKKALLISKSLKRAAKMVQSGILDIQEIQKEMQNILQDLKVEYIAFVDRDFRPLQKIQIGKTIILVAAYVGSTRLIDNIWL
Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Mass (Da): 31241 Sequence Length: 273 Pathway: Cofactor biosynthesis; (R)-pan...
Q5Z2U3
MIDPTLRGAYRPGQLTVHHDPAVLGSVAKALRGVGRTVALVPTMGALHQGHLQIVRQAKRTNQVVIVSIFVNPLQFGAGEDLDKYPRTLDADVELLRAEGVELVFAPNAEQMYPDGPRTTVHPGPLGAELEGASRPTHFAGMLTVVAKLLQIARPHQAFFGEKDYQQLTLIRQMVRDLNFDVRIVAVPTVRESDGLALSSRNRYLDAAQRETALALSAALSAGAHAGGLGAEGVLAAARAVLDATPGLDLDYLELRSSTLGPAPASGNARLLVAAKVGTTRLIDNIAVTLGAPIDGHPNLDSQPEPAGTDPALLPPAR
Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Mass (Da): 33561 Sequence Length: 318 Pathway: Cofactor biosynthesis; (R)-pan...
A1SDW7
MSSAPVLAHTREELATLLAAARARGEQVGLVPTMGALHEGHASLVRAARERVTDDGRMGPVVVSVFVNPLQFGANEDLDRYPRTLEADLEVCAREGADIVFAPSVDEVYPGGPPQVTVRPGPLGKILEGKVRPGHFRGVLTVVAKLFGLVRPDVAVFGQKDYQQLALIRRMVLDLALGVEIVAAETVREDDGLALSSRNRYLEPEQREQAVALSRALLAAQENAGYGAEVALDEARAELRAAPGVDLDYLVITDPDLDELPAVVPPGTPARILVAARVGGTRLIDNLPLMLGTRGPAGEASPPNRERSEPGSAEQNKSPG...
Function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Mass (Da): 35428 Sequence Length: 334 Pathway: Cofactor biosynthesis; (R)-pan...
P40459
MKIFHTVEEVVQWRTQELRETRFRETIGFVPTMGCLHSGHASLISQSVKENTYTVVSIFVNPSQFAPTEDLDNYPRTLPDDIKLLESLKVDVLFAPNAHVMYPQGIPLDIEEQKGPFVSVLGLSEKLEGKTRPNFFRGVATVVTKLFNIVMADVAYFGQKDIQQFIVLQCMVDELFVNTRLQMMPIVRNNNGLALSSRNKYLCPESLKISENLYRGLKAAENAIRRLAPGGRLSRSEIIDTVTQIWAPYVDSHDFKIDYVSLADFKTLDELSDVENTSEQQPIVISCAVYVTDREKPDTVVRLIDNIVI
Function: Required for pantothenic acid biosynthesis. Catalytic Activity: (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+) Sequence Mass (Da): 35032 Sequence Length: 309 Pathway: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: ste...
Q9EYU1
MRKLVAGKLHGIHVTEANLNYHGSITLDPDHCEAAGILPMEFVEIWNKNSGARISTYVILGERGSRCCILNGAAARTCQPDDPIIVCNSIYLDEAHITSLKPRIVTFDQDNHILDRLSYSVDIDTDGRYSFAILDEADEPLVIPALVSGA
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
Q7NDK7
MLRTVLLGKIHRATVTGACLEYVGSISVDSRLLAAAGILPHEQVHVVNLNNGARLVTYAIEASEGSGAVVLNGAAARLAAAGDQVIVLAYGQGTAVELEHHQPQVVYVDAQNRIVSVHRSVEHAG
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
B7K6Z1
MGKIRLMHAKLHRVRVTEANVGYIGSITIDPQLLDRVGILPLEEVDIVNLNNGKRFSTYVFPGEAGTGEVCPNGGAALLCQPGDLLIIYAYEERDRSEVLQQGHHARVIVADENNQIKQFFHQTLIPTEEGKGVSFHSDEIILNGQPKNNPILSEN
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
A1WUU3
MQLNMLKGKLHQARVTQTELEYEGSCAIDLDLLEAVGIHEYEQIHVYNIENGERFVTYAIIGERGSRMISMNGAAAHKCNEGDRVIICAYAGVPESELGEFQPRLAYLDADNRITQRRGSIPLQVA
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
Q18HQ3
MRRWLLKSKLHRARVTGTEKDYEGSISIDAALLSEADIAVGEQVQVVNVTNGERFETYTIEGESRQMELNGAAARLAETGDVIIVISYGLYVKDEQPEPTVLLLDEENRISERE
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
Q7VJB2
MQFEMLYSKIHRAKVSDANLNYVGSITIDKTLAQSANLLAGMKVEIVNINNGERFSTYVIYGDKKGEICLNGAAARKVQIGDIIIIIAYATYTHNELEHYKPTIVQVNESNQILSITNEV
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
P56065
MTFEMLYSKIHRATITDANLNYIGSITIDEDLAKLAKLREGMKVEIVDVNNGERFSTYVILGKKRGEICVNGAAARKVAIGDVVIILAYASMNEDEINAHKPSIVLVDEKNEILEKG
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
Q118E6
MTTIKLMHAKLHRVRVTDAKPDYVGSVTIDSDLLEKVGILPLEEVQIVNLNNGQRWLTYVLPGQAGSGMVCPNGGAALLCKKDDILIIWANEQCDRAEVLENGHKAKIFVADENNHCREFLYQILNPNQGSVEFHSLPVIPEGKTSEYLQQMIETNKI
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
A5CW02
MKRIFLSAKLHKVTTTAVELNYEGSCEIDGVLLDAAGIGAFEQIQIYNINNGNRFTTYTILGKDNSGIISVNGAAARKVNVGDVLIIAAYALYSEEELEGYAPRLCYVNNKNILTKISTGSKKSSLY
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
Q8PLK9
MHLSLLKAKIHRATVTHSELNYEGSIAIDGLLLEATGIREFEQVHIWDVTNGARFSTYAIRAEDGSGIMSLNGGAARHVQVGDLIIVAAFASMSEDEAKTFKPNLVYVNAHNAISHTNHSIPTQAA
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
Q9PGR7
MQLSLLKAKIHRATVSHSELNYEGSIAIDGLLLEAAGLYEFEKVHIWNVTNGARFTTYAIRAEHGSGIISVNGGAARYVQVGDLVIVAAFAQMSEDEAAVFSPNLVYVDAANAMTHTNHSIPTQVA
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
A1JJN6
MIRTMLQGKLHRVKVTQADLHYEGSCAIDQDFLEAAGILEYEAIDIYNVDNGQRFSTYAIAAERGSRIISVNGAAARCACVGDKLIICSYVQMSDADARLHHPKVAYFEGENQLQRKAKAVPVQVA
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group ...
P53632
MGAKSVTASSSKKIKNRHNGKVKKSKKIKKVRKPQKSISLNDENEVEILPSRNEQETNKLPKDHVTADGILVLEHKSDDDEGFDVYDGHFDNPTDIPSTTEESKTPSLAVHGDEKDLANNDDFISLSASSEDEQAEQEEEREKQELEIKKEKQKEILNTDYPWILNHDHSKQKEISDWLTFEIKDFVAYISPSREEIEIRNQTISTIREAVKQLWPDADLHVFGSYSTDLYLPGSDIDCVVTSELGGKESRNNLYSLASHLKKKNLATEVEVVAKARVPIIKFVEPHSGIHIDVSFERTNGIEAAKLIREWLDDTPGLRE...
Function: Catalytic subunit of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA...
Q9LW57
MATSSTFSSLLPSPPALLSDHRSPPPSIRYSFSPLTTPKSSRLGFTVPEKRNLAANSSLVEVSIGGESDPPPSSSGSGGDDKQIALLKLKLLSVVSGLNRGLVASVDDLERAEVAAKELETAGGPVDLTDDLDKLQGKWRLLYSSAFSSRSLGGSRPGLPTGRLIPVTLGQVFQRIDVFSKDFDNIAEVELGAPWPFPPLEATATLAHKFELLGTCKIKITFEKTTVKTSGNLSQIPPFDIPRLPDSFRPSSNPGTGDFEVTYVDDTMRITRGDRGELRVFVIA
Function: Required for plastoglobule development and resistance to multiple stresses. Regulates plastoglobule osmiophilic content. May be involved in the transport of lipophilic antioxidants in and out of the plastoglobule. PTM: Phosphorylated as part of a basal defense response. Sequence Mass (Da): 30455 Sequence Leng...
P00784
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYI...
Function: Cysteine proteinase with a high level of diversity in substrate specificity, an amino acid bearing a large hydrophobic side chain at the P2 position is preferred. Catalytic Activity: Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic s...
Q45066
MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYK...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane pr...
O51066
MDIRTVLKDNFLQYSSYVIKDRAIASVVDGFKPVQRRIIHSLFEMHDGNFHKVANVVGNTMKYHPHGDTSIYEALVNIANKDLFIEKQGNFGNLFTGDPASASRYIECRLTPLAFDVLYSKEITIYESSYDGRNNEPLLYPAKIPVILIQGSEGIAVGMAAKILPHNFNEILNAVKSELLGESYDIYPDFPTGGIVDVNEYADGNGKVLVRAKIETIDEKTIVIRELPFGETTESLISSIEKAIRKNYIKVSSINDFTAENVAIELSLPRGVYASEVIEKLYHYTNCQISISVNLLLLSERYPVVYTIKDLIKFHAAHLQ...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity). Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Periph...
O54478
MNKPVLPPPGGPDDGDRILDEPLTEALSRRYLAYALSTIGSRALPDVRDGLKPVHRRVLYAMSNMRLNPDAAARKCAKVVGEVMGNFHPHGDASIYDALVRLAQEFSQRIPLVEGQGNFGNIDGDSAAAMRYTECKMTEAAMLLLDGIDEDAVDFRPTYDGQDEEPVVLPSGFPNLLANGSSGIAVGMATSIPPHNAAELIDACQLLLANPDATTADLLEKVPGPDFPTGGVIVESRASLLETYETGRGGVRMRAKWEKEDTGRGTYQIVVTEIPYQVKKSDLVEQLADLIDSKKAALLGDVRDESAEDIRLVLEPKSKN...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane pr...
P47446
MDQKNNNLFQKAIEEVFAVSFSKYAKYIIQDRALPDLRDGLKPVQRRILYGMFQMGLKPTTPYKKSARAVGEIMGKYHPHGDSSIYDAIIRMSQSWKNNWTTVSIHGNNGSVDGDNAAAMRYTETRLSLYGFELLKDIDKKLVSFINNFDDSEKEPTVLPTLLPNLFINGASGIAAGYATNIAPHNTNELLDSLCLRIDQPNCELKQILKIVKGPDFPTGGNVYFEKSLSDIYQAGKGKFIIQAKYEVNKNLNQIEITQIPYETLKANIVKQIEEIIFDNKLSAIESVIDSSDRNGIRIIIKHKDFLPAEKIMAFLFKHT...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane pr...
P48374
MNTQPHASHTDSNTLMLGRYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLTAGAKPVKSARVVGEILGKYHPHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAAAMRYTEARLTPIAELLLSEINQGTVDFMPNYDGAFDEPLHLPARLPMVLLNGASGIAVGMATEIPSHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGKGSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDRLNTKKLMLDLIDRVRDESDG...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane pr...
Q9HUK1
MSESLDLSLEGVERRSLAEFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLDADSKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTVDWVPNFDGTLDEPAVLPARLPNLLLNGTTGIAVGMATDVPPHNLREVASACVRLLDQPGATVAELCEHVPGPDFPTEAEIITPRADLQKVYETGRGSVRMRAVYRVEDGDIVIHALPHQVSGSKVLEQIAGQMQAKKLPMVADLRDESDHENPTRIVIIPRSNRVDVEELMT...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane pr...
Q59749
MGQSLLPPSGGDDNIQPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGLRPNSSFKKCARIVGDVIGKFHPHGDQSVYDALVRLAQDFSQRYPVVDGQGNFGNIDGDNAAAYRYTEAKMTEVAALLLEGIDQDAVDFRPTYNEEDQEPTVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALHLIKHPDATVEDLLFDPANPQRGGIEGPDFPTGGVIVESRASMAESYRTGRGGFRVRARWAVEDLGRGGFQIVVTEIPYQVQKSRLIEKIAELLIARKLPLLEDIRDESAEDVRVVLV...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane pr...
Q9ZE79
MKEAKIENIDFGNALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSGYKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTEICMLLMEDIDKDTVDFRSTYDDSDLEPVIMPASFPNLLANGSEGIAVGMATNIPPHNLHELCDALLYLIDNPQAGINDIMNFIKGPDFPTGGIIIDKAEVINAAYTTGRGSFRVRSRWEKEELSYGTYQIVVTEIPYQIQKSKLIEQIAILLKDKKIPLISSIRDESTDIIRVVIEPRDRSCDPQIVMESLFK...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane pr...
P26973
MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTADWVPNFDGTMQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDQLLDIVQGPDYPTEAEIITPRAEIRKIYENGRGSVRMRAVWTKEDGAVVISALPHQVSGAKVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTD...
Function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA . Performs the decatenation events required during the replication of a circular DNA molecule. Catalytic Activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. Location Topology: Peripheral membrane p...
Q99LX0
MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVMICPDTSLEDAKTQGPYDVVVLPGGNLGAQNLSESPMVKEILKEQESRKGLIAAICAGPTALLAHEVGFGCKVTTHPLAKDKMMNGSHYSYSESRVEKDGLILTSRGPGTSFEFALAIVEALVGKDMANQVKAPLVLKD
Cofactor: Deglycase activity does not require glutathione as a cofactor, however, glycated glutathione constitutes a PARK7 substrate. Function: Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stres...
Q2KHV4
MAWRGWAQRGWGCGQAWTLPVCGGSYEELTAALAPSRLLRRRFNFFIQQKCGFRKAPRKVEPRRSDTSSEAYKRSALIPPVEETAFYPSPYPIRTLVKPLFFTVGFTGCAFGSAAIWQYESLKSKVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVFVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISTFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAG...
Function: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cl...
A1Z8R8
MLMSRALCRSWLPQVARRCHANVNVPILRINSGHPAARSCRQIHSNRKQSSNLKPTTGEPAAAEQNTPVPVNNVIKAVAFTGAFTVGCFAGATILEYENTRSLILEKARQARFGWWQSRSLADRDYWTQIKQDIRRHWDSLTPGDKMFAPILLCNLVAFAMWRVPALKSTMITYFTSNPAAKVVCWPMFLSTFSHYSAMHLFANMYVMHSFANAAAVSLGKEQFLAVYLSAGVFSSLMSVLYKAATSQAGMSLGASGAIMTLLAYVCTQYPDTQLSILFLPALTFSAGAGIKVLMGIDFAGVVMGWKFFDHAAHLGGAMF...
Function: Mitochondrial intramembrane protease which plays a critical role in the regulation of mitochondrial function . Essential for mitochondrial development and fusion during spermatogenesis and the development of neurons and muscles . Essential for proteolytic processing of Pink1 and HtrA2 into their mature forms ...
Q9H300
MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKVEPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDT...
Function: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature f...
Q3B8P0
MALYSWVQRGWRCGQTWAPLLGGGYRELSATQARQLLGRRFNLLLQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPVRTLLKPFFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLHRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSTSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAG...
Function: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cl...
Q6UWI2
MVYKTLFALCILTAGWRVQSLPTSAPLSVSLPTNIVPPTTIWTSSPQNTDADTASPSNGTHNNSVLPVTASAPTSLLPKNISIESREEEITSPGSNWEGTNTDPSPSGFSSTSGGVHLTTTLEEHSSGTPEAGVAATLSQSAAEPPTLISPQAPASSPSSLSTSPPEVFSASVTTNHSSTVTSTQPTGAPTAPESPTEESSSDHTPTSHATAEPVPQEKTPPTTVSGKVMCELIDMETTTTFPRVIMQEVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS
Function: May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. PTM: Highly N-glycosylated and O-glycosylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 32289 Sequence Length: 310 Subcellular Location: Cell membrane
Q6P9X9
MVCKALITLCIFAAGLRVQGSPTPTLLPVSLTTKSTAPMATWTTSAQHTAMATTPVASATHNASVLRTTAASLTSQLPTHPREEAVTSPPLKREVNSTDSSPTGFSSNSSGIHLAPTPEEHSLGSPETSVPATGSQSPTLLFSQGPTSASTSPATSPSEPLSASVTSNHSSTVNNIQPTGAPMAPASPTEEHSSSHTPTSHVTEPVPKEKSPQDTEPGKVICESETTTPFLIMQEVENALSSGSIAAITVTVIAVVLLVFGAAAYLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS
Function: May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. PTM: Highly N-glycosylated and O-glycosylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 30729 Sequence Length: 296 Subcellular Location: Cell membrane
Q8W4C3
MQRRFLSSISATAGNTKTLNQGRWSVKQVKKSNFHVTLDEIRTSIDSSDFIALSLQNTGSYAAAWHRVSAIDTPQTSYLKAKYAAERYQILQFALCPFSLQGSKLTVHPYNFHLFPRDELKCGMPSYSFSCQASRLTAMAREGFDFNICIYEGISYLSRAQESASKFLSENPILADSVTVSSSPATVADTVFVGRIRSRVKNWRQSCIDSGSKTGDDDLVSSLRRLVLGSEQYGSRLCLTIDVCSERQVQLILEMLTEFSDDVVPLLVASKSRGTQAVRTVFMSSKEDKDLFKRELKDLEKEENRRVRGFREVVDFISSS...
Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs (By similarity). Catalytic Activity: Exonucleolytic cleavage of poly(A) to 5'-AMP. Sequence ...
Q9LG26
MRRHKRWPLRSLVCSFSSSAAETVTTSTAASATAAFPLKHVTRSNFETTLNDLRSLVKAADFVAIDLEMTGVTSAPWRDSLEFDRYDVRYLKVKDSAEKFAVVQFGVCPFRWDSRTQSFVSYPHNFFVFPRQELTFDPPAHEFLCQTTSMDFLAKYQFDFNTCIHEGISYLSRREEEEASKRLKMLHGEDGIDSSGETEELKLVRLADVLFAARMEKLLNEWRSGLLHGGNASSEFPRISNGSNQSMETVFHHMRPALSLKGFTSHQLRVLNSVLRKHFGDLVYIHSNDKSSSSRDIVVYTDSDSDKENLMKEAKDERKR...
Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. Essential for early development, possibly by participating in silencing certain maternal mR...
Q7ZU92
MEVTRQNFKEVLPEVCNAVQEADFISIDGEFTGISDGPSVSALTNGLDTPEERYTKLRKHSMNFLLFQFGVCTFRYDQNQSTYITKAFNFYIFPKPFSRTSPDIKFICQSSSIDFLASQGFDFNKVFRSGIPYLNQEEECQLREQYEERRGQMNGAGPVSYTPPSGTGVCNVPEDQREFIRSVEEKVEALLKNTDQTLDLEPCTGFQRKLIYQTLNSKYSKGLHVEALETEKKERFIQISKVDDEERRRREQQKQQREQEELNDAVGFSRVIRAISKSGKLVVGHNMLLDVMHTIHQFCGPLPEELDDFKEVAMTVFPRL...
Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation ...
O95453
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFP...
Cofactor: Divalent metal cations. Mg(2+) is the most probable. Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence c...
P21861
MPGTAEVQVRPGVEEDLKPLTDLYNHYVRETPITFDTEPFTPEERRPWLLSHPEDGPYRLRVATDAESQEILGYATSSPYRAKPAYATSVETTVYVAPGAGGRGIGSLLYASLFDALAAEDLHRAYAGIAQPNEASARLHARFGFRHVGTYREVGRKFGRYWDVAWYERPL
Function: Inactivates phosphinothricin (PPT) by transfer of an acetyl group from acetyl CoA. The physiological substrate could be a structurally related compound. Catalytic Activity: acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin Sequence Mass (Da): 19205 Sequence Length: 171 EC: 2.3.1.183
P16426
MSPERRPADIRRATEADMPAVCTIVNHYIETSTVNFRTEPQEPQEWTDDLVRLRERYPWLVAEVDGEVAGIAYAGPWKARNAYDWTAESTVYVSPRHQRTGLGSTLYTHLLKSLEAQGFKSVVAVIGLPNDPSVRMHEALGYAPRGMLRAAGFKHGNWHDVGFWQLDFSLPVPPRPVLPVTEI
Function: Inactivates phosphinothricin (PPT) by transfer of an acetyl group from acetyl CoA. Can also acetylate demethylphosphinothricin but not PTT or glutamate. This enzyme is an effector of phosphinothricin tripeptide (PTT or bialaphos) resistance. Catalytic Activity: acetyl-CoA + phosphinothricin = CoA + H(+) + N-a...
Q57146
MSPERRPVEIRPATAADMAAVCDIVNHYIETSTVNFRTEPQTPQEWIDDLERLQDRYPWLVAEVEGVVAGIAYAGPWKARNAYDWTVESTVYVSHRHQRLGLGSTLYTHLLKSMEAQGFKSVVAVIGLPNDPSVRLHEALGYTARGTLRAAGYKHGGWHDVGFWQRDFELPAPPRPVRPVTQI
Function: Inactivates phosphinothricin (PPT) by transfer of an acetyl group from acetyl CoA. This enzyme is an effector of phosphinothricin tripeptide (PTT or bialaphos) resistance. Catalytic Activity: acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin Sequence Mass (Da): 20618 Sequence Length: 183 E...
A0A1U8QHE3
MTCADVTDLCTQASQLVQQLRTKDGELGFMSAAVYDTAWVSMVQKTTPEGRQWLLPKCFEYILRTQLEDGSWETYASDVDGILNTAASLLALETHAESRIASTDPPVEEMKERIGRARAALSRQLQAWSVKDTVHVGFEIILPALLRLLREKGHEFEFDGRAELDRLNRIKLSKFRPEYLYSARTTALHSLEAFVGMIDFDKVAHQKVNGSFMFSPSSTAAFLMFSSSWDDECEQYLRLVLQNGAGGGTGGMPSAYPSKYFEVSWVRGQLARLESKLTELQALTTLLDNGYSTGDLGIEDTDSLGEMLRDALVKGGGIVG...
Cofactor: Binds 3 Mg(2+) ions per subunit. Function: Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) . Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors . The g...
A0A1U8QLG8
MSPPLDSALEPLSEYKETAFPRTEKDPSQYKEHDLVTPEKEIQTGYFSPRGSHSSHGSHDSSASSNISLDDARMSDVNNSPNVFHDDPDTIDEKLSMYWKAANETVIREPYDYIAGIPGKEIRRKLLEAFNHWYKVDEQSCQAIATTVGMAHNASLLIDDIQDSSKLRRGVPCAHEVFGIAQTINSANYVYFLAQNQLFRLRSWPQAISVFNEEMVNLHRGQGMELFWRDNLLPPSMDDYLQMIANKTGGLFRMIVRLLQTSSRQVIDVEQLVDVLGLYFQILDDYKNIREEKMAAQKGFFEDLTEGKFSFPICHAIGEG...
Cofactor: Binds 3 Mg(2+) ions per subunit. Function: Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) . Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors...
C8VN86
MPESQIIELGTLGQIPLYSLERALQDPLRAVKLRRQIVSQHQATGNIDFTTDGSALPYEGYDYKAVLGACCENVIGYMPIPVGVAGPIKINGKMVFLPMSTTEGALVASTNRGCMAINAGGGVTALVLGDGMTRAPIVRFPSLEEAGAAKQWLGSDAGFLIIEDAFNASSRFARLQNIKATAVGSDLYIRFTASTGDAMGMNMISKGVEQALEAMQKHGFESMDVVSLSGNFCADKKPAAVNWIEGRGKTVTAQATIPEHAVRETLKTSVEALVELNVSKNLVGSAVAGALGGFNAHAANVVTAIYLATGQDPAQNVQSS...
Function: 3-hydroxy-3-methylglutaryl coenzyme A reductase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) . Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors . The geranylgeranyl pyrophospha...
A0A1U8QXK4
MNTLNAPRNPTRHPAMTADTLVDAPALPHQNGSTEEKLKERGSFGKLYTYKRSPRALGIQAVAKSIGLELEQVELQPANGVPDFYWNLNPLGKTPTFVGADGLVLTECMAIALHVTNEDSTTTLLGSSSLDFVQIIRWISFTNTDVVTRMASWVRPLIGYTPYSKEEVLKAQQQTTQAIGVFEDSLRDRKYLVGDRLTLADIMCVSLVSFGFAQIFDKEWREAFPYFSGWYMMVMHLPIMKAVVEEVPFVEEGLPNAPPTEPFRAP
Function: Glutathione S-transferase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) . Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors . The geranylgeranyl pyrophosphate (GGPP) synthase AN1...
A0A1U8QP15
MVSLKTVQASNAGLRALPNITALFVGGTSGIGQSTLRQLARYADSPTAYIIGRNEARTRPFLSELQQLNPKGRFHFIEADVSLVRNVDAACQQILQQQKKLNFLFMTPGGISLGGRNETVEGIDYLFALRYYSRMRFIQNLLPLLEASSPSRVISVYGGGFEYSINTADLDLKHNFSLLNAYKHSITMTSLSMEHLARTHPAVSFIHVYPGLVGTNIYTNSFPAPVSTFYNYLVWPFMKPFSVDLGESGERHLFHLSSAHYPAKQGIVPQGVPLEAGEVAKGITGEPGSGAYLLNWKGDVRPSTKILAQYREQKIPQLVW...
Function: Oxidoreductase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) . Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors . The geranylgeranyl pyrophosphate (GGPP) synthase AN1592 is need...
A0A1U8QJR1
MVDATSPPGVNAVVNYYVPNSDGSPPATNDMAVMLGQKDMISHKMRIRDLRPYKEEYSLDRNGFQYATIHSTLTDATDETQIKEVYYREIEKLVQDITGAKRVLAFHHAVRTRTGNEFGEQIKDRYQGVEGPAYRVHIDQTPQGALSIVQFMFPDLADDVRNGSFQVINVWRPLTRVQRDPLMVADAAEMPPEDLLLISRKYYNGLHSSNFVIKYDGRMAAGEGPTDGLSGDGKHSWWYIGDQEPTEALVFSSSGFRNGKAIIGTAHDLYSAEPMINAYERKNASSLYGHDESQI
Function: Oxidoreductase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) . Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors . The geranylgeranyl pyrophosphate (GGPP) synthase AN1592 is need...
C8VN91
MDNYTWHSGTLIPSDSPSSIDRSQLYLEILGVLSVVYLLQTLVAYSKSFKAPFVGFRFWYEPKWLVGLRFSQGALAQVNEGYAKYKNAMFKVARNDSDILVIPNKYVEELRSLPDEKISAIRAHIKNLLGKYSTTLILLESDLHTRMLQTKLTPNLGSFIEVIESELLFAMDQEIPANLDDWQSVNVFHIVLRIVARISARVFLGVPACRNEEWLQTSIHYTENVFATVMLLRRFPKWMHPIVGHLLPSYWAIHRNLRTAKRIISPMVRQRRAEEAKRNPDYVKPNDLLQWMMDGANENDGQPDKLAHRQLLLSLASIHT...
Function: Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) . Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors . The geranylgeranyl pyrophosphate (GGPP) synthase...
Q9FE20
MGCFSCFDSSDDEKLNPVDESNHGQKKQSQPTVSNNISGLPSGGEKLSSKTNGGSKRELLLPRDGLGQIAAHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGEQNLVAWARPLFNDRRKFIKLAD...
Function: Protein kinase required for plant defense mechanism mediated by the disease resistance (R) protein RPS5. In case of infection by Pseudomonas syringae, AvrPphB triggers RPS5-mediated defense mechanism via the cleavage of PBS1. Both kinase activity and cleavage by avrPphB are independently required to trigger t...
P08018
MEDKFANLSLHEKTGKSSIQLNEQTGSDNGSAVKRTSSTSSHYNNINADLHARVKAFQEQRALKRSASVGSNQSEQDKGSSQSPKHIQQIVNKPLPPLPVAGSSKVSQRMSSQVVQASSKSTLKNVLDNQETQNITDVNINIDTTKITATTIGVNTGLPATDITPSVSNTASATHKAQLLNPNRRAPRRPLSTQHPTRPNVAPHKAPAIINTPKQSLSARRGLKLPPGGMSLKMPTKTAQQPQQFAPSPSNKKHIETLSNSKVVEGKRSNPGSLINGVQSTSTSSSTEGPHDTVGTTPRTGNSNNSSNSGSSGGGGLFAN...
Function: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Seems to phosphorylate HOG1 on a tyrosine residue. PTM: Activated by phosphorylation by SSK2 or SSK22. Ser/Thr phosphorylation is also necessary for SHO1-mediated activation. Catal...
Q9XUV0
MWGETFDDFENDEGEMAMAKQNLIAEPARADFTFAKLPLGIQPVDFMKTHFAETAGKSMQFRKGTTTLAFVYEPATPADKGGIIVAVDSRASSGEYISSKSVMKILDIGDRMVATMAGGAADCQFWTRIVAKYCTLYELREKTSITVSAASKYFANTLYGYRGQGLSVGSMVAGYDKKGPQIFKVDSEGDRCQLKVCSVGSGSLNAYGILDNHYKPKMTDDEARKLGLRAIMHATYRDSGSGGVCNLCHITPTEKIRLPPMDVSKLWYEFADELGRDITYNPVE
Function: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins . This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S prot...
Q08017
MSASRFMLRPLTRALLMHGATRTRLAGTGLGLALTLTAAPYVQAQEWTLNIPSQPLAQALQTLGQQTSLQIIYSPESLQGLRSTALNGRYQDDESLKAMLNGTGIRYQRDGNTVTVLGPATGSAMELAPTNVNASRLGATTEGSNSYTTGGVTIGKGVHSLKETPQSVTVMTRKMLDDQNLNTIEQVMEKTPGITVYDSPMGGKYFYSRGFRMSGQYQYDGVPLDIGSSYVQADSFNSDMAIYDRVEVLRGAAGMMKGAGGTAGGVNFVRKRGQDTAHTQLSLSAGTWDNYRGQVDTGGPLNDSGTIRGRAVVTEQTRQY...
Function: Specific receptor for the siderophore ferric pyoverdine (pseudobactin) M114. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 90388 Sequence Length: 826 Subcellular Location: Cell outer membrane
Q797E3
MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLISVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAAMSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILFLGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTLYAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFAIIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPD...
Function: Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and inosine, as well as purine bases guanine, adenine and hypoxanthine, and purine base analogs 2,6-diaminopurine, 6-mercaptopurine and 2-fluoroadenine. Therefore plays a role in maintaining the cellular purine base pools and prote...
O34987
MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESVKDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMGISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSGIITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGLVPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQAGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGV...
Function: Involved in the uptake of the purine bases hypoxanthine and guanine. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 46191 Sequence Length: 440 Subcellular Location: Cell membrane
O34978
MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFDQVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAVFTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLVTLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSLPHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKLPNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLT...
Function: Involved in the uptake of the purine bases hypoxanthine and guanine. May work at purine concentrations higher than 100 uM. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 45420 Sequence Length: 432 Subcellular Location: Cell membrane
P42086
MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYLVSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIASGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNLALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQPFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLAVLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFG...
Function: Transport of xanthine in the cell. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 46238 Sequence Length: 438 Subcellular Location: Cell membrane
P40424
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHG...
Function: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 . Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein . Has also been shown to bind the DNA sequence 5'-ATC...
O60330
MIPARLHRDYKGLVLLGILLGTLWETGCTQIRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQ...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 100955 Sequence Length: 932 Subcellular Location: Cell membrane
Q9Y5G2
MKASSGRCGLVRWLQVLLPFLLSLFPGALPVQIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRVSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIE...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 100875 Sequence Length: 931 Subcellular Location: Cell membrane
Q9UN71
MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEAR...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 99927 Sequence Length: 923 Subcellular Location: Cell membrane
Q9Y5G0
MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDG...
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 99875 Sequence Length: 923 Subcellular Location: Cell membrane
Q9PP01
MKKFDKLGLDNIKEIFHNLSYDELNAHEKANNEGLSTDNDTFCVDTGIFTGRSPKDKYFVKQDPSSKYIAWGKVNQPITKELFDKLLTKAKQELSGKKIYVQDVFCGASLQSRKAVRFVTEIAWQAHFVKNMFIRPSQEELENFKADFIVYNACKCINEDYKQDGLNSEVFVIFNVEENIAVIGGTWYGGEMKKGIFSMMNYWLPLENKLSMHCSANVGEKDDVALFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDEGVFNFEGGCYAKTINLDPEHEPEIYGAIKRNALLENVVLRADKSVDYADASKTENTRVSYPIE...
Cofactor: Binds 1 Mn(2+) ion per subunit. Function: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Catalytic Activity: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate Sequen...
Q21BR2
MQETGVRNGAYGADKFGLKNLKGVKWNLTAPHLYEDALRAGEGVLSGDGSLCVDTGIFTGRSPKDKYTVRDANTENTMWWGGNQSITAEQFENLYQDFLKHAEGMSLFAQDLYGGADPSFQIKTRVFTEMAWHSLFIRTLLRRPETAELASFVPELTIIDLASFRADPARHGCKSENVVAIDFTRKIVLIGGTQYAGEMKKSVFTTLNYYLPDKGVLPMHCSANVGPDGDTAIFFGLSGTGKTTLSADPNRTLIGDDEHGWGKDGVFNFEGGCYAKCIKLSAEAEPEIFAASNRFGAILENCVLDPITRKPDFNDGSKTE...
Cofactor: Binds 1 Mn(2+) ion per subunit. Function: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Catalytic Activity: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate Sequen...
Q13E86
MQETGVHNGAHGADKFGLKNLKGIYWNFGAPQLYEHALRNGEAVLSADGALVADTGVFTGRSPKDKFTVRDATTETTMWWGGNQSITAEQFETLYQDFIKHAEGMTLFAQDLYGGADPSFQIKTRVFTELAWHSLFIRTLLRRPDRADLAAFVPELTLIDLPSFRADPKRHGCRSENVVAIDFARKIVLIGGTQYAGEMKKSVFTTLNYYLPERGVLPMHCSANVGPAGDTAIFFGLSGTGKTTLSADPNRTLIGDDEHGWGKDGVFNFEGGCYAKCIKLSPEAEPEIFAASSRFGAVLENVVLDEITRKPDFDNGSKTE...
Cofactor: Binds 1 Mn(2+) ion per subunit. Function: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Catalytic Activity: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate Sequen...
Q16AH6
MTHGRVNPDFRLEDQGITGLGTVYYNLIEPDLIQYALARGEGSLGKGGSFLVTTGKFTGRSPKDKHVVKTDSVADTIWWENNREMSPEGFDQLYTDMLAHMEGRDYFVEDLTGGSDPKHAINVRMVTELAWHGLFIRHMLRRPDREDLDDFIADFTVINCPSFQADPAKHNCRSETVIAMNFDKKLILIGGTEYAGENKKSVFTLLNYLLPEKGVMPMHCSANHAVGNPVDTAVFFGLSGTGKTTLSADPARTLIGDDEHGWSDTGTFNFEGGCYAKTISLNPEAEPEIYATTEKFGTVIENMVYDAETKDLDFEDDSLT...
Cofactor: Binds 1 Mn(2+) ion per subunit. Function: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Catalytic Activity: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate Sequen...
Q1AY78
MDLAVRKMTLEGLGVSQLGAVHENLPPARLVEASVRRREGMLAENGALVCLTGKRTGRSPKDRFIVENGLTRGPVDWGPVNKPFPGERFERLLAKASAYLENLEEVYVVDAYAGADPRYRLNVQVVCEYAWQALFTRQLFRRPSREELDAFEPDWTVISVPGLLTDPEEDGTESETFVGIDFGRRVVLICGTRYAGEIKKSIFSVLNFVLPTEHGVFPMHCSANVGPGGDVALFFGLSGTGKTTLSSDPERYLIGDDEHGWSDEGIFNFEGGCYAKCIDLSREKEPQIYDAIRFGAVLENVVVDRITRRVDYSDASLTEN...
Cofactor: Binds 1 Mn(2+) ion per subunit. Function: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Catalytic Activity: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate Sequen...
O54075
MTAEGPLAPEDRVLDREAIGRLCVSLIAAEQQDLLREGRVGHHQMIGARLLTAGHPSPDDLLIDEDTLGLDSLLMLSLVTRVAGFFHLSDSNTEDYLLVRRRLGEWVDLIDHHHTLMGPKARFTFATSGSTAGPKPVTHSAAALLSEGQAIAKILTERPPEVRRVLSCVPAHHIYGFLWSCLFPSRRGLEAKQLANLSASGIMRHARSGDLVVGTPFIWEQFADLDYRLPGDVVGVTSGAPSTAETWRCASALGPARMLDIYGSTETGGIGWRERRDDPFRTLPDLACFHDTLSRLGRRLDLQDEIAWDKDGGFTILGRK...
Function: Converts p-coumaric acid into p-coumaryl CoA. This is necessary for the activation of the photoactive yellow protein (PYP) chromophore. Catalytic Activity: (E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate Sequence Mass (Da): 45008 Sequence Length: 411 EC: 6.2.1.12
P42516
MQGLNADEVLRLLRSLIPGELATGRGQRGDPPEAQDLCADSRLDAEPIRADSLDRLNLASALNRFFRLHETGVEDRLLAVRRIGDMAELIADASQHTSGLTFSTSGSTGTPQPHHHSWAALTQEAEALANALGSHPRVIAWLPVHHLYGFVFGVALPRALGSTVIESHAAPTALFREPAPDDLIATVPARWRYLFDSNHRFPGGTGISSTAALETACRNGLLQAGLDALLEVYGATEAGGIGLRWAPSEDYRLLPHWHGDATATSSALNPDGAAVTVAPLDRLQWRDERVFRPTGRIDDIIQIGGVNVSPGHVARRLESH...
Function: Converts p-coumaric acid into p-coumaryl CoA. This is necessary for the activation of the photoactive yellow protein (PYP) chromophore. Catalytic Activity: (E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate Sequence Mass (Da): 42439 Sequence Length: 391 EC: 6.2.1.12
O69140
MVRRLLISLIRAEARRGRNQILPEAAFTGDPRIDEEGLGFDSLARLDLIGAVRDFFDLSRTGIEDYVYVEPTLQGWIDRIMQHFDLLAARSETAQAVFRTSGSTGTPKPIPHPWPKLMREAASMARDQGLVPAPGGAVIGLVPAHHLFGCLFTALLPELAGAALRDLTAAPPASALRTAQPGDLIIATPHLWAHLGAAGAFPPGLRGVSSGAPMPDALWHSLLAAGLEDLTEVYGASETGGIGLRRAPGAAFTLLPFLSRSADDGISDGPAPLPLQDRLRWTGPVRFVIEGRLDQALQVGGVNVRLGHVKSVLEAEPGVE...
Function: Converts p-coumaric acid into p-coumaryl CoA. This is necessary for the activation of the photoactive yellow protein (PYP) chromophore (By similarity). Catalytic Activity: (E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate Sequence Mass (Da): 40942 Sequence Length: 384 EC: 6.2.1.12
A7IQE5
MNQAAVQLPLPGFEQASGQWRSDYSRQVAGEKPVRNRSGIEVQPLYSPRDWAGERYLDDLGFPGQYPFTRGIYPSMHRGRTWTQRQLIGLGTPQDYNVRVRRIIDAGATAISLLPCCSGFRGIDCDEVDPVLLGTCGTVVNTTDHMDAALDGVPLGTISTAMNDPSPFTLLAFTLGVARRRGIDWRSITGTSNQSDYISHFIANHQFYRLSLPGSRRVLLDHIEFCRRALPNWNPLSVVGQHMQQAGATPAETMGFTLSSAIQYAQDCIERGMDVDDVLRRFTFFFDISISFFEEIAKFRAGRRIWARIARERLGAKDPA...
Function: Together with Xaut_5044, catalyzes the reversible isomerization between pivalyl-CoA and isovaleryl-CoA, using radical chemistry. Does not exhibit isobutyryl-CoA mutase (ICM) activity. Catalytic Activity: 3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA Sequence Mass (Da): 61992 Sequence Length: 559 EC: 5.4.99...
Q9SWW5
MEVASLYRRVLPSPPAVEFASAEGKRLFAEALQGGTMEGFFNLISYFQTQSEPAFCGLASLSVVLNALAIDPGRPWKGPWRWFDESMLDCCEPLHKVKAEGITFGKVVCLAHCAGARVQSFRADQTTIHDFRAHLTRCASSQDCHLISSYHRSPFKQTGTGHFSPIGGYHAEKDMALILDVARFKYPPHWVPLTLLWDAMNTTDEATGLLRGFMLVSRRSSAPSLLYTVSCGHGSWKSMAKYCVEDVPNLLKDESLDNVTTLLSRLVESLPANAGDLIKCVIEVRRKEEGESSLSKEEKERLFLKEKVLQQIRDTDLFRV...
Function: Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants. Catalytic Activity: [Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine Sequence Mass (Da): 55045 Sequence Length: 500 EC: 2.3.2.15
Q9ZWB7
MSMASLYRRSLSPPAIDFASFEGKQIFNEALQKGTMEGFFGLISYFQTQSEPAFCGLASLSMVLNSLSIDPGRKWKGPWRWFDESMLECCEPLEIVKDKGISFGKVVCLAHSSGAKVEAFRTNQSTIDDFRKYVVKCSTSDNCHMISTYHRQVLKQTGTGHFSPIGGYNAERDMALILDVARFKYPPHWVPLKLLWDAMDSIDQSTGRRRGFMLISRPHREPGLLYTLSCKDESWISIAKYLKEDVPRLVSSQHVDTIERILYVVFKSLPANFNQFIKWMAEIRRTEDVNQNLSSEEKSRLKLKQELLKQVQETKLFKHV...
Function: Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants. Catalytic Activity: [Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine Sequence Mass (Da): 51551 Sequence Length: 452 EC: 2.3.2.15
Q6UW60
MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTDPWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTL...
Function: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization even...
P29121
MRPSQTELWLGLTLTLALLAVRWASAQAPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKDPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIQQDLNILKAWNQGLTGRGVVISILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVG...
Function: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm...
P29122
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGR...
Function: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. Location Topology: Perip...