ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
A3PDP9
MKLKSLLSVFTISIVALTSACSTKNAGPSADPDKLIVALIPDENAATVIQDNQGLKDYLTEAFDKEIELVVTTDYSSMIEAARNDRLDLAYFGPLSYVLAKAVSDIEPFAARIKGGTKTYNSCIIGNTKKGVTSFDDIKGTTFALGDPASTSSRLFPELTLAENGLTKGKDFQGVFLGSHDAVALAVQNGNAQAGGMACPILKSLKKKGVIDPSKVTTIAQSSPIPQYPWTMRSTLSPELKEKIRFTFLDLDSDKVLKPFNADGFASITDSDYDGIRKAGKLLGLDLSKFVK
Function: Probably part of the ABC transporter complex PhnC2D2E2. Binds strongly to methylphosphonate (MPn), ethylphosphonate (EPn) and inorganic phosphite. Location Topology: Lipid-anchor Sequence Mass (Da): 31304 Sequence Length: 292 Subcellular Location: Cell membrane
A0QQ71
MKIRAHHKIATAAACVALLASACSGSDKPQSTTAEGFPETITLAAIPAENSSDLKASYDPLIKMLEKQTGSKVEFVQASDYAGVVEGMIAGNVDLAFFGPFAYVVAGVNGAKMTPLGAVIKDEGGAPGYQSYGLARADEDNINGLKDFAGKKVCFVDPGSTSGFLYPTAGLIEEGVVKSGSEADISAAMSPIFAGGHDSSALAIANGDCDAGFAFDTMVDKTMIDKGDLKPGQLKTVWKSDMIAGSVFAANDALGPEVIDKLKTMFAQDANVKSFEEEGFCEGDACRITDERAWGVVPVTDADYDGVRHVCDVTGSEKCK...
Function: Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for phosphate binding. Location Topology: Lipid-anchor Sequence Mass (Da): 33385 Sequence Length: 321 Subcellular Location: Cell membrane
A0A142C7A2
MYAFTILGFKRDDMTEDEYHNYISTVHSAHLKALLAQNDIVSYTMQHNTSQTRDDLLNKVYQGQMPAEKVFECDAIIQVVFKTVEDYLRVREDPHFQTVVNPDHVNFAHPTKTRFVMGWHEVHVADGKVVS
Function: Dehydratase; part of the gene cluster that mediates the biosynthesis of phenalenones such as herqueinone, compounds that have been reported to treat tumors, bacterial infections and/or mycoses, and rheumatic diseases . The non-reducing polyketide synthase phnA synthesizes the heptaketide backbone and cyclizes...
P0DP69
MPDAVQAPYPAYRPEPNMQTITIAPPKRSWFSLLSWAVVLAVLVVSWQGAEMAPLTLIKDGGNMATFAADFFPPDFSQWQDYLTEMAVTLQIAVWGTALAVVLSIPFGLMSAENLVPWWVYQPVRRLMDACRAINEMVFAMLFVVAVGLGPFAGVLACWRCLSTPPACSPSCFPKRWKRLSPARWKAFAPPVPTSSKRSSTACCHR
Function: N-terminal fragment of the PhnE protein, part of a phosphonate usage operon that is cryptic in K12 strains. Growth of K12 strains on phosphonate can be observed when it is used as the sole phosphorus source after a 60 hour lag period, suggesting the operon is activated . An intact PhnE in strain B is (AC A0A1...
P0DP70
MLALFIHTTGVLSKLLSEAVEAIEPGPVEGIRATGANKLEEILYGVLPQVMPLLISYSLYRFESNVRSATVVGMVGAGGIGVTLWEAIRGFQFQQTCALMVLIIVTVSLLDFLSQRLRKHFI
Function: C-terminal fragment of the PhnE protein, part of a phosphonate usage operon that is cryptic in K12 strains. Growth of K12 strains on phosphonate can be observed when it is used as the sole phosphorus source after a 60 hour lag period, suggesting the operon is activated . An intact PhnE in strain B is (AC A0A1...
Q7ZAP3
MNRIHAVILDWAGTTVDFGSFAPTQIFVEAFRQAFDVEITLAEARVPMGLGKWQHIEALGKLPAVDARWQAKFGRSMSAADIDAIYAAFMPLQIAKVVDFSSPIAGVIDTIAALRAEGIKIGSCSGYPRAVMERLVPAAAGHGYRPDHWVATDDLAAGGRPGPWMALQNVIALGIDAVAHCVKVDDAAPGISEGLNAGMWTVGLAVSGNEFGATWDAYQTMSKEDVAVRREHAASKLYAAGAHYVVDSLADLPGVIAHINARLAQGERP
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Involved in phosphonate degradation. Catalytic Activity: H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate Sequence Mass (Da): 28574 Sequence Length: 269 EC: 3.11.1.1
A0LMC1
MEIFVRNKPYTGPVKAVVLDWAGTTVDFGCMAPVTAFIEAFALRGVEISASEVRGPMGLMKMDHVRALCGLPSVSERWRELFGRIPNEDDVRLVYGDTVPLMVLSVADHAELIPGLLPAIGYFRGNGIKIGTSTGYTTPMMEVLLPRAEKRGYRPDSVVCSSDVPRGRPFPFMCYRNAIDLEVYPLEAVVKIGDTVSDIREGLNAGMWTIGVSKSGSDLGLTEAELDALPADDLRNRLALVESRFLEAGAHFVVEHIGRCPEIIEEINDLLSQGEVP
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Involved in phosphonate degradation. Catalytic Activity: H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate Sequence Mass (Da): 30294 Sequence Length: 277 EC: 3.11.1.1
Q87JL6
MSNSPIQAVIFDWAGTIVDFGSFAPTSIFVEAFKQGFDFDIDLEEAREPMGLGKWDHIQAVGRIPAVDKRWNEKFGRSMTNEDIDAIYAAFMPLQKAKVADHAEPILNAVEVVNGLKDKGIKIGSCSGYPREVMDVLIPVAADYGYQPDYVVATDDLPQGGRPAPFMALKNVIELDVTDVKACVKVDDSAPGIFEGHNAGMWTVGLLLSGNEAGLTFEEYQAADEATLEKAREKARAKFIKSAPHYLIDTISDLPEVIVDIEQRLAAGERP
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Involved in phosphonate degradation. Catalytic Activity: H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate Sequence Mass (Da): 29649 Sequence Length: 271 EC: 3.11.1.1
Q6E0X0
MNRYSRRSRHPNPPVPNQEEPERDPNHIDQDLADLAQPLVLKERHAVMAPTQPSLSDVINEERQAPITFGNPPEVMANARLSALGYDNLTEREKRILAVGVRCGEAAKDYHSLTTTKKWIEDELKSQMVALASSTRTLTEAASLHTTFAMLHSPSIKRKAEAMSHISQGEESIDISKLNKTGMEDIWVAMESESKEDAVDTYLRNILEVDPTQFYAIDGWGLYLDFIPTWHYIAAGKNSAQFKTSYADEIVEQRAAFERVLSKRPRVEI
Function: Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA (By similarity). PTM: Phosphorylated by host kinases. Seque...
Q5MKM7
MEKFAPEFVGEDANKKAEEFLKHRSFPSEKPLAGIPNTATHVTKYNMPPILRSSFKLPSPRVAANLTEPSAPPTTPPPTPPQNKEEQPKESDVDIETMHVCKVPDNPEHSKKPCCSDDTDTKKTRKPMVTFVEPEEKFVGLGASLYRETMQTFAADGYDEESNLSFEETNQEPGSSSVEQRLDRIEEKLSYIIGLLNTIMVATAGPTTARDEIRDALIGTREELIEMIKSDILTVNDRIVAMEKLRDEECSRADTDDGSACYLTDRARILDKIVSSNAEEAKEDLDVDDIMGINF
Function: Plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins. Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex. Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA. Acts as ...
Q9JGU0
MDKKASGISGENALFGDVPNDVVGTTYEMGLDGIFDDGETDVIESPADAEEHVTTDIVADEGDNLITKVDDMIGYLKRECQDHGIAVRKEWVNVLTRKFHMSKKIYASHLDFFLLGVMGERHVAVEKDFKDTAVRLSDEVNKMSGISKKVADNETRMIKELDAKMKEMGSLIGKFNGVLNEFKGSMAVSSRPASVASWALDQTTETSREKNYNEFLKKLGFQDHHIKSPLMKKCTVMITDEMYDEVMLENTSEDTLGIYKEQIITYGQSIQKKVEKPIKKDPYADF
Function: Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA (By similarity). PTM: Phosphorylated by host kinases. Seque...
A9CJC9
MSLKTAPVIVWFRKDLRLSDNLALLAAVEHGGPVIPVYIREKSAGPLGGAQEWWLHHSLAALSSSLEKAGGRLVLASGDAERILRDLISETGADTVVWNRRYDPTGMATDKALKQKLRDDGLTVRSFSGQLLHEPSRLQTKSGGPYRVYTPFWRALEGSDEPHAPADPPKSLTAPKVWPKSEKLSNWKLLPTKPDWAKDFSDIWTPGETGALDKLDDFIDGALKGYEEGRDFPAKPATSLLSPHLAAGEISPAAVWHATKGLSRHIASNDISRFRKEIVWREFCYHLLFHFPELGEKNWNDSFDAFSWRDDEKSFKAWTR...
Cofactor: Binds 1 FAD per subunit. Function: Photolyase involved in the repair of UV radiation-induced DNA damage. By using blue-light energy, catalyzes the photoreactivation of cyclobutane pyrimidine dimers (CPDs), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. C...
Q00829
MKSKWMSGLLLVAVGFSFTQVMVHAGETANTEGKTFHIAARNQT
Function: Signaling molecule involved in the regulation of sporulation . Secreted during production, but the mature peptide acts intracellularly, indicating that it needs to be imported into the cell to function . Inhibitor of the RapA phosphatase activity . Does not act on RapB . PTM: Secreted with a propeptide domain...
P11394
MKTPLTEAVAAADSQGRFLSNTEVQAASGRFNRAKASLEAAKALTSKADSLVNGAAQAVYSKFPYTTQMEGSNYSATPEGKAKCSRDVGYYLRMITYCLVAGGTGPMDDYLIAGLDEINRTFELSPSWYVEALKHIKANHGLSGDAATEANSYIDYAINALI
Function: Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex. PTM: Contains one covalently linked bilin chromophore. Location Topology: Peripheral membrane protein Sequence Mass (Da): 17335 Sequence Length: 162 Subcellular Location: Cellular thylakoid membrane
A9CH39
MSQLVLILGDQLSPSIAALDGVDKKQDTIVLCEVMAEASYVGHHKKKIAFIFSAMRHFAEELRGEGYRVRYTRIDDADNAGSFTGEVKRAIDDLTPSRICVTEPGEWRVRSEMDGFAGAFGIQVDIRSDRRFLSSHGEFRNWAAGRKSLTMEYFYREMRRKTGLLMNGEQPVGGRWNFDAENRQPARPDLLRPKHPVFAPDKITKEVIDTVERLFPDNFGKLENFGFAVTRTDAERALSAFIDDFLCNFGATQDAMLQDDPNLNHSLLSFYINCGLLDALDVCKAAERAYHEGGAPLNAVEGFIRQIIGWREYMRGIYWL...
Cofactor: Binds 1 FAD per subunit. Function: Photolyase involved in the repair of UV-induced (6-4) lesions in DNA. Catalyzes the photoreactivation of (6-4) pyrimidine-pyrimidone photoproducts by using blue-light energy. Can repair (6-4) photoproducts in ssDNA as well as in dsDNA. Catalytic Activity: (6-4) photoproduct ...
P94416
MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT
Function: Signaling molecule that serves as a cell density signal for both genetic competence development and sporulation . Secreted during production, but the mature peptide acts intracellularly, indicating that it needs to be imported into the cell to function . At low concentrations, CSF stimulates expression of the...
O32025
MKSKLFISLSAVLIGLAFFGSMYNGEMKEASRNVTLAPTHEFLV
Function: Signaling molecule involved in the regulation of sporulation . Secreted during production, but the mature peptide acts intracellularly, indicating that it needs to be imported into the cell to function (Probable). Inhibitor of the RapE phosphatase activity . Does not inhibit the phosphatase activity of RapA a...
P71001
MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI
Function: Signaling molecule involved in the regulation of genetic competence development . Secreted during production, but the mature peptide acts intracellularly, indicating that it needs to be imported into the cell to function (By similarity). Stimulates expression of the genes controlled by ComA, a transcriptional...
O32295
MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG
Function: Signaling molecule involved in the regulation of expression of DegU-controlled genes . Secreted during production, but the mature peptide acts intracellularly, indicating that it needs to be imported into the cell to function (By similarity). Stimulates the DegU-dependent expression of aprE, an extracellular ...
Q59HN7
MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDHSPYKLSDQKKALS
Function: Signaling molecule involved the regulation of both sporulation and competence . Secreted during production, but the mature peptide acts intracellularly, indicating that it needs to be imported into the cell to function . Acts by inhibiting RapH activity . Can inhibit both RapH activities, the dephosphorylatio...
Q8MZS4
MRLLSLLFLLGLATLSFAVRSQWAQQGRATHEALITIRFALTQQNLDVLERTLLDISDTTSKNYGKWKTAEEVTELVAPAREISERVASFLERQGATKVENFRDMVKVTAPVSWIEETLHTNLFFFQHKTRTSKVIIRADGGYKIPAEIAEHVDFVAGLFEFPSIKNARTQVGAGVDGYIVPYVIFDLYGIPTTFPVHPNSSICLVEFQDDQSYNKDDLKKFAKENEITETVVSHTVGPYSGSSADTESTLDVQYGGAIALNTTVWFWTVEDWMYDFATDFLNTKNPPLVVSMSWGWPEPEQCQVGNCTGDETSLEYVVR...
Cofactor: Binds 1 Ca(2+) ion per subunit. PTM: Autocatalytically processed. Catalytic Activity: Milk clotting activity. Preferential cleavage of 8-Gly-|-Ser-9 in B chain of insulin most rapidly, followed by 11-Leu-|-Val-12, 19-Cys(SO(3)H)-|-Gly and 24-Phe-|-Phe-25. No action on Ac-Phe-Tyr(I)2. Sequence Mass (Da): 62709...
Q715L4
MEEDFNMSTPGVKVGVXEEEKKLSYYKYYEQDLAPVPAEKIAILQGGPIAPEKCIPFDERNKFLKGEDDEYANIGFGVAADGTALVCNTTYMPGVTGEMLDWWFPWHSVGSDLRYKIWDPEDHYFARAYPASYVVDPNVPMNQKTWGVDHYIMEDVGPGPEFLKLCFKRPADFGYDESIIGTEKCESLVCAIGESSCAAAMTHKWHPYKDGVLFESRFWIGYRIDEEGNIVKAIPEGVSIPPFVPQGLFAHNIKEFTNLAAILPTLYAEEKDTF
Function: Catalyzes the hydrolytic C-C cleavage of phloretin to phloroglucinol and 3-(4-hydroxyphenyl)propionic acid during flavonoid degradation. Also hydrolyzes other C-acylated phenols. Catalytic Activity: H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate Sequence Mass (Da): 30923 Sequence Length: 274 Su...
B1MK49
MHPITYYPVDTQRLVRSNAERIRHKPYAHYFNPDVAVPEEVFAALKAPLEPEQVLGTSSTELNRLLEPGYLEGETGYCGLPDGAGYTSSLVRFPGATPEMFRWWFWWHSFEPERYSLWHPWCHADIWRTDPETETAPNLTDEQRYVGSTHHINEYIGQDPLDIEITFIDPARWGFDADGFAAAGIGAHACGSVLMKGSHMRLATMVHLARITDDGFELRSRYWIADRAEPRHDPVAGIAQLTTVPGFSGERQAYEQLVHDQTEFNHLATFLPDIYQEFGPR
Function: Catalyzes the hydrolytic C-C cleavage of phloretin to phloroglucinol and 3-(4-hydroxyphenyl)propionic acid. Can also hydrolyze monoacetylphloroglucinol (MAPG) but not 2,4-diacetylphloroglucinol (DAPG). Catalytic Activity: H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate Sequence Mass (Da): 32091 ...
Q9UBF8
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPV...
Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity...
B3EX61
MGDTAVEPAPLKPASEPAPGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVRLLHGAVAVSKRGTALELVNGDGVDTEIRCLDDPPAQIREEEDEMGATVTSGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPALNTGLSPSKRTHQRSKSDATASISLSSSLKRTASNPKVENEDEPIRLAPEREFIKSLMAI...
Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane traffickin...
A4IID4
MGDTMVEPVPAKLSDPTLVLRGNGGSPLCVITEGVGEAQMVIDPDVAEKACQDVLDKVKLIRGSSAESLDKIDGSDTGDGGSLANGDAGPRHSESCGPPVSASRITEEEESLIDINSVKSARRRQKNNSAKQSWLLRLFECKLFDVSMAISYLYNSKEPGVQAYIGNRLFCFRYEDVDFYLPQLLNMYIHMDEDVGDAIKPYVVHRCRQSINFSLQCAWLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHKKREIPPLSLAPDTGLSPSKRTHQRSKSDATVSISLSSNLKRTSSNPKVENDDEPVRLAPEREFIK...
Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May play an important role in the inner ear development. Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3...
Q99755
MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKI...
Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesio...
D3ZSI8
MASASSGPAAAGFSPLDSGVPAGTAASGIKRGTVSEGPYASLMPVKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELSNSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHMKYDLKGSTYKRRASQKEREKTLPTFKDLDFLQDIPDGLFLDADMYSALCKTLQRDCLVLQSFKIMDYSLLMSIHNMDHAQ...
Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesio...
O14986
MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKSGDG...
Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesio...
P70181
MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNVPDAKRPGMQKVLYSTAMESIQGPGKSADG...
Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesio...
Q9Y2B2
MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKKELLQSCDVLGIPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVLTLQSVNVLRKYISLLDLPLSLLHTQDVLFVLNSKEVAQAKKAMSCHRSQLLWFRRLYIIFSRYMRINSLSFL
Function: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. Catalytic Activity: a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol Location Topology: S...
O35790
MEVVGLLCVAVAVLTWGFLRVWNSAERMRSPEQAGLPGAGSRALVVIAHPDDEAMFFAPTILGLARLKQQVSLLCFSSGNYYNQGEIRKKELLQSCAVLGIPPSRVMIIDKREFPDDPEVQWDTEHVASTILQHIHANATDLVVTFDAEGVSGHSNHIALYKAVRALHSGGKLPEGCSVLTLQSVNVLRKYVFLLDLPWTLLSPQGVLFVLTSKEVAQAKKAMSCHRSQLLWFRHLYTVFSRYMSVNSLQLL
Function: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. Catalytic Activity: a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol Location Topology: S...
Q500W7
MSRESENTDDEPSKWMKFRSLLVFSMLLRVFLIVYGEWQDAHMEVRYTDVDYIVFSDAASLMASGESPYKRTTYRYSPLLALLLTPNSFFHRSWGKFLFSASDLLVGWFIHKILKQRKVPEKICTYSVMVWLFNPFTFTIGTRGNCEPIVCAMILWIILCLMQGNLLQAAFWYGLVVHFRVYPIIYALPIILVLDTQVFRSGQKPALLYWNTGQAKTPASNMERKTFLFNLLTTLKSLFSRERIMFALISGGVFLACNAVSFYFYGQEFLHEALLYHLTRTDPRHNFSIYFYHIYLHYERQFSAVEKLISFLPQFTVQFA...
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 52946 Sequence Length: 450 Pathway: Glycolipid biosynthesis; glycosylphospha...
Q5F380
MAGGRPGLRAALGAGLLARLSLVLYGLYQDAVMRVRYTDVDYRVFTDAARLVTQGRSPYRRATFRYTPLLAWLLTPNVHLGELFGKLLFVAGDLAAAGVAYRALRRRGASPGRACGCCAAAWLLNPLPMAVSSRGNAEALVAVLVLAALHLVEAGSVGRAALCYGLAVHLKIYPLTYALPIALRLQGSGEGAAGAGRDGTAEFTLVGGIWRRVVRVLNRNVLLFGAVAGSVLAALTVLFYHLYGWEFLEHAYLYHLTRRDIRHNFSPYFYMLYLTAESKWSFALGLAAFLPQLLLLLVVSVAFYKDLFFCCFLHTAIFVS...
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 46577 Sequence Length: 418 Pathway: Glycolipid biosynthesis;...
Q54IA4
MTRVKTVMTNENNKYDFIFKGINLTKSIFIVGLVIRLVLIVFAEWQDANMLVKYTDIDYVVYTDASRAVVNGLSPYDRSTYRYTPLLAYLLVPNILIHPAFGKLLFVICDMIIAYLLKGILLERFPKITSRTLLICLASWLLNPFSINVSTRGNAESVIGAMVLASFYFLTKKNLTLASIFYGLSVHFKIYPIIYSIPMYLYIDENFFSRKPSEYTSLNNNFKNIFKNFFNKNRLKFFLISAFTFISLTFIMYLIYGYIFLFETYLYHVIRADNRHNFSVYFYQIYLNTPIVETVGDLVGKVNGSNMIVALASFLPQVIL...
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 51328 Sequence Length: 442 Pathway: Glycolipid biosynthesis;...
Q9H3S5
MGSTKHWGEWLLNLKVAPAGVFGVAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCDLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLH...
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49460 Sequence Length: 423 Pathway: Glycolipid biosynthesis; glycosylphospha...
Q4R4E1
MGSTKHWGEWLLNLKLAPAGVFGVAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVAEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCDLLTAFLLYRLLLLKGLARRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIRKRVVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQSRYTFQAHLYELLKRLCDRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQFILLSAVSFAYYRDLVFCCFLH...
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49451 Sequence Length: 423 Pathway: Glycolipid biosynthesis;...
Q5W259
MVNDTFEQALQNAINIARLAPSSHNCQPWSVHYDAATRCGEVSIDRQRALKGLPSLEREMLMSCGIFFEYLSTLLKHSGYPLDWQWVGARQNGSSGMLISFAPSAPCVADLVAYQQWVQRISDRHTVRTAYQPTQVNEQQQAQLYALFDRSPVTCDIKYGEATRHDVAFLTANYASLDFADQQAWRETYHYIRFNEQQAAEDGFYLHHLFGPVSCGFRWFFRIAFHPRLSWLAKRLRLPASMAKGLAELVVEGPQYLALSLEHESDENLFIAGMKLGQLWLMLQSWGWSLHPLSVLVQHATARCALADTVRLTGLPVFFA...
Function: Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the oxidation of the hydroxy group of 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM) to yield 4-methoxy-2,2'-bipyrrole-5-carbal...
Q9BPQ5
MELQSLIDTVSLQKLLLLGALLRLILIAYAFFHDQWFRVKYTDIDYMIVVDGARHMWNGGSPFDRTTFRYTPLLAALVMPSIWIANPMGKLIFASSDLGAAWYCYGVLKSFAKERSAKWMVSLFILFNPIVLSVSTRGNSDMLVTFMSLMVLSKFARRKCYQAAAVLGFAVHFKIYPIIYALPLTLGVWEQSVAASTNTWRRVVKTAVVVSICALMAAISFAVPTVLCYMKYGQQYLNEAFIYHVYREDHRHNFSPYWLLMYLNMARRHLGQGVDFSPRLVAFAPQAVVLSFVSYKLRRNTAHACCVQTVLFVAFNKVCT...
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-PI during GPI precursor assembly (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 48849 Sequence Length: 430 Pathway: Glycolipid biosynthesis; glyc...
Q66IJ4
MMKQAGILKIFLQHQFMFPTAFFLRSALVLFGVYQDQTMLVKYTDVDYHVFTDAAEYLTQGVSPYKRATYRYTPLLAWILTPNIYVTELYGKMLFVCCDLLAAYLIHRILVDRGIKDSASLYCAIWLFNPLPMVVSSRGNAESVLAVLVLSVLYYVQKRRLIKGALIYGLSVHMKIYPITYILPIALFFQKEDFYGSQEGKRVVSNLKYIRIFRNLLQRLLSRDILLFVTVSGVTFALLTLFFYYRYGWEFLENTYLYHLTRRDIRHNFSPYFYMLYLTAENNNSFILGLAAFFPQLVLLFVVSLAYFKDLPFCCFLHTA...
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49036 Sequence Length: 419 Pathway: Glycolipid biosynthesis;...
O95427
MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVN...
Function: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome misseg...
Q9R1S3
MLLFFALGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYELDEDGNSRAPFIRNVIIHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVN...
Function: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. May act as suppressor of replication stress and chromosome missegregation. Locati...
Q9C999
MSGFSSGNVNSRVVDILSGVVPLLKLICLTVIGLLLAHPKTQLVPRATFRLLSKLVFALFLPCLIFTELGESITLDNIVQWWFIPVNVLLSAVVGSLIGYLVVLICRPPPEFNRFTIVMTAFGNTGNLLLAIVSSVCHTKTNPFGPNCNSRGVSYVSFAQWVAVILVYTVVYHMMEPPLEYYEVVEEEGVEIEEINVENHDASRPLLVEAEWPGIEDKETEHCKTPFIARVFNSISSFSQTSFPEVDLGGEYGGESSSPRSIQCLAEPRVMRRIRVVAEQTPVKHILQPPTIASLLAIIIGSVPQLKSVVFGYDAPLSFI...
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 49880 Sequence Length: 457 Subcellular Loca...
Q9C9K5
MVKLLELFITSSKPVVEILLITSVGFYMALDGVNLLGHDARKYLNNIVFYVFSPSLIGSRLADSVTYESLVKMWFMPVNVLLTFIIGSLLGWIVIVITKPPSHLRGLILGCCAAGNLGNMPLIIIPAVCKEKGGPFGDPESCQKYGMGYVALSMAMGSIYIWTYVYNLMRVLSNSPVETPPSVESNYDSYKVPLISSKEEENNQKAGRWEKVKRRLVSLSQKVNLKTIFAPSTIAAMIALVIGLITPLRKLIIGTEAPLRVLQDSVTLVGDGAVPAMTMIIGGNLLKGLRSSGMKMSSIIGVLVARYVLLPMSGVLIVRG...
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 42632 Sequence Length: 390 Subcellular Loca...
Q9C9K4
MKLLELFIASSKPVVETLLITSVGFYLALDTVNLLGHDARKHLNNIVFYVFSPSLIGSRLADSVTYESLVKMWFMPVNVLLTFMIGSLLGWIVIVITKPPSQLRGLIISCCASGNLGTMPLIIIPAICKEKGGPFGDSESCEKYGMGYVTLSMTAFFISVYKHDTNWYVSGGNGLLMDLYINLMRVLSNSPVETHTHSIESNYDDSCKVQLISSKEEEKEEDNHQVGRWEEVKQRVVSLSKKVNLGSIFAPATIAAIIALVIGLITPLRNLIIGTVAPFRVIQDSLTLLGDGAIPAMTLILGGNLLKGMRRSEVRSSEMK...
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 45586 Sequence Length: 415 Subcellular Loca...
Q9SHL8
MGFWSLLEVASMPVIQVLFMSLVGAFMASDRCKLFPVEARNSMNKVVFVLFAPALMFANLAQTVTLEDIISWWFMPVNMGLTFLIGGLLGWLVVKILKPPPYLEGLIVATCSAGNMGNLPIILVPAICDEDKSPFGNRSVCRTVGLSYASFSMALGGFYIWTYTFRLIKGSAMKVQAIEESEKIAIKSSNSDLEADHKTHLLGAPEDKENKVVKEKTGFWRKGVDFLHEILEELLAPPTLGAIIGFIFGAVRWLRNLIIGDDAPLRIVQSTAKLLGDGTIPCMTIILGGNLIQGLRSSAVKPMVVLGIVCVRYIAMPIIG...
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43394 Sequence Length: 396 Subcellular Loca...
Q9LZN2
MIARILAALADSMEMPVAAGGGSVLGTIKIAVMPIAKVFTMCFLGLLMASKYVNILPPSGRKLLNGLVFSLLLPCLIFSQLGQAVTLQKMLQWWFIPVNVVLGTISGSIIGFIVASIVRPPYPYFKFTIIQIGVGNIGNVPLVLLAALCRDTSNPFGDSEKCSIDGTAYISFGQWVGAIILYTYVYQMFAPPPEGFDAEEENLALKTLPVDAAPEQVPLLTQNFPKDFSPTQDLLPVQSTEPRGRGVSRKGKIAQIFVFLYEKLKLKQIVQPAIVASILAMILGAIPFTKKLIFTNGAPLFFFTDSCMILGDAMIPCILL...
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 46465 Sequence Length: 431 Subcellular Loca...
Q9FKY4
MGFLELLEVASMPIVQVLLISVLGAFLATDYCSLLSADTRRSVNKLVFVVFTPCIMFANLAETVTLQDIISWWFMPINVGITFLVGGILGWLVVKLLNPKPQLHGLIIATCASGNMGNLMLILVPAICDEEGSPFGNRSVCRSIGLSYASFSMALGGFYIWTYSYQLVRSSATQFRALEAAGLVKSPNKDIDSDPHALLLKPHQNQDLEIQGKQKVSTRTYIKDLLHQILEELFAPPTIGAILGFVFGATNWLRNLIIGENAPLRVIQDSVKLLGEGTIPCITLILGGNLIQGLRSSAVKKSVIVGVIIVRYILLPVVGV...
Function: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43074 Sequence Length: 395 Subcellular Loca...
P33639
MRAERLRLSEEQGQRILRLYHLYRLTIGLVLVLLISSELEDQVLKLVHPELFHVGSWCYLVFNILVALFLPPSRQLLPIFILALTDVLMLCGLFYAGGGVPSGIGSLLVVAVAIANILLRGRIGLVIAAAASLGLLYLTFFLSLSSPDATNHYVQAGGLGTLCFAAALVIQALVRRQEQTETLAEERAETVANLEELNALILQRMRTGILVVDSRQAILLANQAALGLLRQDDVQGASLGRHSPMLMHCMKQWRLNPSLRPPTLKVVPDGPTVQPSFISLNREDDQHVLIFLEDISQIAQQAQQMKLAGLGRLTAGIAHE...
Function: Member of the two-component regulatory system PilS/PilR that regulates the expression of multiple genes including the type IV pilus (T4P) major subunit PilA . Thereby, plays a major role in the regulation of multiple motility pathways . Functions as a membrane-associated protein kinase that phosphorylates Pil...
P24559
MDITELLAFSAKQGASDLHLSAGLPPMIRVDGDVRRINLPPLEHKQVHALIYDIMNDKQRKDFEEFLETDFSFEVPGVARFRVNAFNQNRGAGAVFRTIPSKVLTMEELGMGEVFKRVSDVPRGLVLVTGPTGSGKSTTLAAMLDYLNNTKYHHILTIEDPIEFVHESKKCLVNQREVHRDTLGFSEALRSALREDPDIILVGEMRDLETIRLALTAAETGHLVFGTLHTTSAAKTIDRVVDVFPAEEKAMVRSMLSESLQSVISQTLIKKIGGGRVAAHEIMIGTPAIRNLIREDKVAQMYSAIQTGGSLGMQTLDMCL...
Function: ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers . Acts as a molecular motor to provide t...
G3XCX3
MEFEKLLRLMVEKGGSDLFITAGVPPSMKVNGRVMPVTKTPLSPEQTRETVLGVMNEQQRRDFAENHECNFAISARGIGRFRVSAFYQRNLVGMVLRRIETNIPTLEELKLPEILKKLALTKRGLVIFVGATGTGKSTSLAAMIGYRNKNSTGHIISIEDPIEYIHQHQGCIVTQREVGLDTDSFEVALKNTLRQAPDVIMIGEVRSRETMDHAVAFAETGHLCLATLHANNANQALERIIHFFPADRHGQVWMDLSLNLKAIVAQQLVPTPDGKGRRAVIEVLLNTPLAADLIRKGEVHELKPLMKRSTEQGMQTFDQA...
Function: ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers . Functions as a PilT-dependent retracti...
P11309
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis . Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylati...
P06803
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDLLPQAASEIHLHSLSPGSSK
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis . Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylati...
P26794
MLLSKINSLAHLRAAPCNDLHANKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIVKGQVYFRQRVSSECQHLIRWCLSLRPSDRPSFEEIQNHPWMQDVLLPQATAEIHLHSLSPSPSK
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylatio...
Q9YHZ5
MLDKRIVDVRLDQLEILKAKNGKEHFEKQYTMGNLLGSGGFGSVYSGHRISDGQKVAIKQISRDRIQQWSKMPGEVNPVPNEIALLQSLGGGSGSVPGHRGIIRMLDWFEIPGQEYLIVFEKPQHCQDLFDFITERGALDESLARRFLKQVIEAVQFCHSKGIVHRDIKDENILVDTRTGDIKVIDFGSGATLKDSMYTDFEGTRVYSPPEWILYHKYHALPLTVWSLGVLLYDMVCGDIPFEQDTDIVKAKPSFNKRISNDCRSLICSCLSYNPGDRPSLEQILQHPWMMESSVDNGDLQEESKIKPSL
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. PTM: Autophosphorylated. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 35102 Sequence Length: 310 EC: 2.7.11.1
Q9P1W9
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signa...
Q07N42
MPLAPPPEKMMFQLSLRRRGISDQAVLRAMDAVPRDLFVTPDLRDEAWRDTALPIACGQTISQPFVVAYMTEQLQLKPEHRVLEIGTGSGYQAAVLSRLCQQVLTLERFKTLADSARARLESLECHNVEVQLGDGFDVPAKAGLFDRILVTAAMEEVPGALIARLDLDGILIAPVGPHQATQTLVRIRNAKGGIERKELVAVRFVPALPGIAREL
Function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Catalytic Activity: [protein]-L-isoaspartate + S-adenosyl-L-m...
Q6NCU3
MVERQIAARGVHDPRVLAAMRKVPREAFLPEPMRDLAYEDAPVPIAAEQTMSQPYIVALMVEALLLQGSDNVLEIGAGSGYAAAVLGEIAGHVTTVERIATLADAAAAKLAELGYGDVDVHRSDGTRGWPAAAPYDAIVVAAGGPQVPESLKAQLKIGGRLVMPVGADQQAQELVRLTRLGEADFKREHLGDVRFVPLLGAEGWQQPEPAGRTAREKG
Function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Catalytic Activity: [protein]-L-isoaspartate + S-adenosyl-L-m...
Q136H9
MVSSVAPPPEKMMFQLSLRRRGISDRAVLQAMEAVPRDRFVDPVHRDGAWRDTALPIACGQTISQPFVVAYMTEQLRLEAGHRLLEIGTGSGYHAAVLSRLVRDVVSVERFKTLADRARARLKELNYANVEVLLGDGFAIPEGAGTFDRIIVTAAMTELSQPLLDLLDPGGILIAPIGPANGRQTLIRVERKDDDFIRKALVDVRFVPALTGIAREL
Function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Catalytic Activity: [protein]-L-isoaspartate + S-adenosyl-L-m...
Q2RTH7
MSVPSRKIRLIMELRQNGVSATPVLAAIERVPRDAFVSAPFSDQAYENTALPIGCGQTISQPLVVGLMTQALDLNDRHKVLEIGTGSGYQTAVLARLCRRVYTIERHGALLREAEARLTALGLHRTVVTREGDGGRGWPEQAPFERILVTAAALDIPKVLVAQLAIGGVMVLPVGKESGAQEVVRVRRTAEDALVTERLFPVRFVPLVDGLPPRDAPGA
Function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Catalytic Activity: [protein]-L-isoaspartate + S-adenosyl-L-m...
Q08733
MEGKEEDVRVGANKFPERQPIGTSAQTDKDYKEPPPAPFFEPGELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVFYIVMQCLGAICGAGVVKGFQPNPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHAWDDHWIFWVGPFIGAALAALYHQLVIRAIPFKSRS
Function: Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg(2+). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 30633 Sequence Length: 286 Domain: The Asn-Pro-Ala (NPA) motifs may contribute to the formation of two hemipores that could g...
Q9AR14
MEGKEEDVRLGANRYSERQPIGTAAQGTEEKDYKEPPPAPLFEAEELTSWSFYRAGIAEFVATFLFLYISILTVMGVSKSSSKCATVGIQGIAWSFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRALFYMVMQCLGAICGAGVVKGFQEGLYMGAGGGANAVNPGYTKGDGLGAEIVGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIVYNRSHAWNDHWIFWVGPFIGAALAAIYHVVIIRALPFKSRD
Function: Water channel required to facilitate the transport of water across cell membrane. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 30725 Sequence Length: 288 Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signatu...
Q1PE40
MRRVSWSTVLIVVVMVSLFFVEHVVVPAAAGRVLTEKSGDGSATMTVEKMKSTVDSWFQRLASGPSPRGRGH
Function: Endogenous secreted peptide that acts as elicitor of immune response and positive regulator of defense response. Amplifies the immune response triggered by flg22, the active epitope of bacterial flagellin. Acts as negative regulator of root growth. PTM: Contains 4-hydroxyproline; hydroxylated on Pro-65 and Pr...
P43286
MAKDVEAVPGEGFQTRDYQDPPPAPFIDGAELKKWSFYRAVIAEFVATLLFLYITVLTVIGYKIQSDTDAGGVDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLPRALLYIIAQCLGAICGVGFVKAFQSSYYTRYGGGANSLADGYSTGTGLAAEIIGTFVLVYTVFSATDPKRSARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFVLRASGSKSLGSFRSAANV
Function: Water channel required to facilitate the transport of water across cell membrane. Probably involved in root water uptake. Its function is impaired by Hg(2+). PTM: Ubiquitinated by RMA1, leading to proteasomal degradation. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 30474 Sequence Length...
Q6K215
MAKDIEASAPEGGEFSAKDYTDPPPAPLIDVEELTKWSLYRAVIAEFIATLLFLYITVATVIGYKHQSDATVNTTDAACSGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLIRAVLYIIAQCLGAICGVGLVKGFQSSYYARYGGGANELSDGYSKGTGLGAEIIGTFVLVYTVFSATDPKRNARDSHIPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGTAVIYNKDKAWDDQWIFWVGPLIGAAIAAAYHQYVLRASAAKLGSYRSNA
Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 30498 Sequence Length: 288 Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with...
Q9UG56
MATSVGHRCLGLLHGVAPWRSSLHPCEITALSQSLQPLRKLPFRAFRTDARKIHTAPARTMFLLRPLPILLVTGGGYAGYRQYEKYRERELEKLGLEIPPKLAGHWEVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFPPAASCDSFKNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTA...
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) . Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at t...
Q8BSF4
MAASGGRACVRSLRGGVLWRSSPCHYESTATRHFLGTLQKLPLQAGVRNFHTAPVRSLFLLRPVPILLATGGGYAGYRQYEKYRERKLEKLGLEIPPKLASHWEVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDLPFPPASSSDSFRNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA...
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at th...
D3ZAW2
MAVAGGRGCVRSLREGVLWRSSPCHCDYTATRHFLGALQKLPLQAWVRKVHTAPLRTLFLLRPVPILLAAGGGYAGYRQYEKYRERQLEKLGLEIPPKLASHWEVSLYKSVPTRLLSRACGRLNQVELPSWLRRPVYSLYIWTFGVNMTEAAVEDLQHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRACTEDLPFPPASSCDSFRNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA...
Cofactor: Binds 1 pyruvoyl group covalently per subunit. Function: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at th...
Q59RA2
MPSAKSSDLSPTKTNLESTTKQKVSVQDIFLYIPNLIGYLRIITAIISFLCMANHPVATLIFYGISGFLDAFDGYAARKFNQGTRFGAVLDMVTDRCATSSLIVYLGVLYPQYTVFWQILVSLDLSSHYMHMYAMLSAGSTSHKNVDETQSKLLSLYYNNRLVLFFVCLINELFYMAVYLHYYKFFWLGTVMLVASTPIWLFKQIANIIQLKNASLILARMDAHDHSKRD
Cofactor: Catalytic activity is higher with Mg(2+). Function: Catalyzes the synthesis of phosphatidylinositol (PtdIns) . Required for proper membrane dynamics and cell wall integrity . Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) Loca...
Q10153
MGKNEQKDPNVYFFVPNLIGFTRVFLVLISLYFMSWHPNYCTIVYLYSSLLDAFDGWAARKLHQATNFGAILDMVTDRCATSCLLCFLCAAYPKYAIIFQLLVSLDLASHYMHMYSTLHQGASSHKTVTKKHNWMLRLYYGNNKVLFIFCAANEMFFVALYLLSFTPRTPPKLGYLPVPSFIYSTGELPLSYPTLLAVLCGPICLAKQIINVVQLVNAANALVKMDVEQRRAAKKLQ
Cofactor: Divalent metal cations; Mn(2+) or Mg(2+). Function: Catalyzes the synthesis of phosphatidylinositol (PtdIns). Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 26...
P06197
MSSNSTPEKVTAEHVLWYIPNKIGYVRVITAALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLCVQYPQWCVFFQLMLGLDITSHYMHMYASLSAGKTSHKSVGEGESRLLHLYYTRRDVLFTICAFNELFYAGLYLQLFSNSATFGKWTTIISFPGYVFKQTANVVQLKRAALILADNDAKNANEKNKTY
Cofactor: Divalent metal cations; Mn(2+) or Mg(2+). Function: Catalyzes the synthesis of phosphatidylinositol (PtdIns). Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 24...
P28069
MSCQAFTSADTFIPLNSDASATLPLIMHHSAAECLPVSNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLVEEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR
Function: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes . Sequence Mass (Da): 32912 Sequence Length: 291 Domain: The...
Q05749
MTCQAFASSDNFVPLNSDSSPSLPLIMHHSAAECLPVSNHATSVVSTVPSVLSLIQTPKCSHLHFAMMTSGNVSAGLHYSVPSCHYGNQTSTYGVMTGIKPATPEMLSASLSQSRILQTCSMPHPNVVNGVSTLQSKSFSFSCSLTPCLYKFPEHALSASSCALGHSFTPMHQTLLSDDPTAADFKQEFRRKSKSVEEPVDMDSPEIRELEKFANEFKLRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENSQLSFKNACKLKSILSKWLEEAEQVGALYNEKVGVNERKRKRRTTISIAAKEALERHFGEQSKPSSQ...
Function: Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. Sequence Mass (Da): 41191 Sequence Length: 370 Domain: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Subcellular...
Q9HYF1
MFESAEVGHSIDKDTYEKAVIELREALLEAQFELKQQARFPVIILINGIEGAGKGETVKLLNEWMDPRLIEVQSFLRPSDEELERPPQWRFWRRLPPKGRTGIFFGNWYSQMLYARVEGHIKEAKLDQAIDAAERFERMLCDEGALLFKFWFHLSKKQLKERLKALEKDPQHSWKLSPLDWKQSEVYDRFVHYGERVLRRTSRDYAPWYVVEGADERYRALTVGRILLEGLQAALATKERAKRQPHAAPLVSSLDNRGLLDSLDLGQYLDKDAYKEQLAAEQARLAGLIRDKRFRQHSLVAVFEGNDAAGKGGAIRRVTD...
Cofactor: Has low activity with Co(2+) or Ni(2+). Function: Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Cannot dephosphorylate ADP in the presence of polyP. Catalytic Activity: [phosphate](n) + ADP = [phosphate](n+1) + AMP Sequence Mass (Da)...
Q886D9
MFESAEIGHAIDDDTYEAALPSLREALLEAQIDLHEQAKRQIIVLINGIEGAGKGETVKLLSEWMDPRLIEVRTFDQQTDEELAHPPVWRYWRQLPAKGRMGIFFGNWYSQMLQGRVHGQYKDAVLDQAISGAERLEKMLCDEGALIFKFWFHLSKKQMKLRLKTLKDDPLHSWRISPLDWQQSKTYDKFVRFGERVLRRTSRDYAPWHVIEGVDANYRSLTVGRLLLEGMQAALNKVEPESSALTIGPLAIHNNERTLLDSLDLSLHLSKEDYQHELIAEQARLSGNLRDKRMKSHALVAVFEGNDAAGKGGAIRRVAA...
Function: Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Catalytic Activity: [phosphate](n) + ADP = [phosphate](n+1) + AMP Sequence Mass (Da): 57955 Sequence Length: 498 EC: 2.7.4.33
M9XB82
MKKYRVQPDGRFELKRFDPDDTSAFEGGKQAALEALAVLNRRLEKLQELLYAEGQHKVLVVLQAMDAGGKDGTIRVVFDGVNPSGVRVASFGVPTEQELARDYLWRVHQQVPRKGELVIFNRSHYEDVLVVRVKNLVPQQVWQKRYRHIREFERMLADEGTTILKFFLHISKDEQRQRLQERLDNPEKRWKFRMGDLEDRRLWDRYQEAYEAAIRETSTEYAPWYVIPANKNWYRNWLVSHILVETLEGLAMQYPQPETASEKIVIE
Function: Uses inorganic polyphosphate (polyP) as a donor to convert both AMP to ADP and ADP to ATP. Can also use GMP, CMP, UMP, GDP, CDP and UDP. Catalytic Activity: [phosphate](n) + ADP = [phosphate](n+1) + AMP Sequence Mass (Da): 31559 Sequence Length: 267 EC: 2.7.4.-
Q9P0L9
MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQETAYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRL...
Function: Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) . Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration . Th...
Q9NZM6
MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLE...
Function: May function as a subunit of a cation channel and play a role in fertilization. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 73790 Sequence Length: 624 Subcellular Location: Membrane
G5EFU0
MNRTFSLRRKVKKSEISTPSNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAELKTVIRGPSSSFRYNSPLPFGMTNSPMPSVARSNSLRISATASPVVNVSSARHSFRPTLPPVSQRGYPFNDPSYAPLPLRNQKPPMSTTFGVEKPHQYQQIITIVAPSRTTTPQLQPKSPSTPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTAT...
Cofactor: Divalent cations such as magnesium or manganese. Function: Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration. Catalytic Activity: ATP...
P28178
MGKGQSKIKNGGSGKPAKAGKPKKGNKNDETTPTSTPTPTPTPTQQNLDNSAQQQQQQQQTTTAAVSLDNKEQQQQQNIPAPATQTPITQTGTPTIEESQKNTDNNNINGASNEASSSPDSPNGSGNGNDDEDEGPEEVIFSKNKQSATKDDFELLNVIGKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKSEKTILQCISHPFIVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYAAEIVSALDHLHKQDIVYRDLKPENILLDSEGHICITDFGLSKKIETTDGTFTFCGTPEYLAPE...
Function: Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. PTM: Seems to be myristoylated. Location Topology: Lipid-anchor Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mass (Da): 52994 Sequence Length...
P41676
MKPEQLVYLNPRQHRIYIASPLNEYMLSDYLKQRNLQTFAKTNIKVPADFGFYISKFVDLVSAVKAIHSVNIVHHNINPEDIFMTGPDFDLYVGGMFGSLYKTFIKNNPQNITLYAAPEQIKKVYTPKNDMYSLGIVLFELIMPFKTALERETTLTNFRNNVQQMPASLSQGHPKLTEIVCKLIQHDYSQRPDAEWLLKEMEQLLLEYTTCSKKL
Function: Plays a role in the inhibition of host eIF2alpha/EIF2S1 phosphorylation, thereby increasing viral fitness. In the insect host, targets the endogenous insect heme-regulated inhibitor (HRI)-like eIF2alpha kinase. Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] Sequence Mas...
Q9TXI7
MIPGMRATPTESFSFVYSCDLQTNVQVKVAEFEGIFRDVLNPVRRLNQLFAEITVYCNNQQIGYPVCTSFHTPPDSSQLARQKLIQKWNEWLTLPIRYSDLSRDAFLHITIWEHEDDEIVNNSTFSRRLVAQSKLSMFSKRGILKSGVIDVQMNVSTTPDPFVKQPETWKYSDAWGDEIDLLFKQVTRQSRGLVEDVPWLDPFASRRIEMIRAKYKYSSPDRHVFLVLEMAAIRLGPTFYKVVYYEDETKNMRVSTSVNGGVGIVSACTRYCVADPELLLESLAEVKHSAMTRRIRDVEDERHRQVKPNKQAKDRLETIV...
Function: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate . Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking . Plays a role in endosome-to-Golgi retrograde transport of ...
Q8NEB9
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFR...
Function: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis ...
Q6PF93
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGSAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFR...
Function: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis....
O88763
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFR...
Function: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis....
Q9P7Y3
MSYWVELWESIFTPGVTPVLAKSAHVACGALVAVFLGLYIGTKSIHCLILFFLAICLWLSLTWFLVELAHARVNNDLQMSSQSANKNDDNSNNQNPSNNKEMSDKESDSATTTQTFSVPEELLRARTTANNS
Function: Functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V(0). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 14613 Sequence Length: 132 Subcellular Location: Endoplasmic reticulum membrane
Q03880
MANFFVRLWESVFEPGTSPQLIIATHVSFVALLLTLIWLIYATNGNIHFYALFCISLLLWITVIWFINELSHVKLKDNDELDKDANKKDDSAIKEDSEDKQESGKSTSTARRTQAQSRSRKA
Function: Functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V(0). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 13962 Sequence Length: 122 Subcellular Location: Endoplasmic reticulum membrane
Q8NFJ6
MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVEC...
Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Location Topology: Multi-pass membrane protein Sequence Mass (Da): ...
Q8K458
MGPQNRNTSFAPDLNPPQDHVSLNYSYGDYDLPLGEDEDVTKTQTFFAAKIVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWAHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAVPSAYFTTETILVIVKNQEKIFCGQIWSVDQQLYYKSYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTVVVKEKHYLTAFYVVECIAM...
Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). Location Topology: Multi-pass membrane protein Sequ...
Q7VEV2
MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHASAKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLITATVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVAALVSVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRSHLYPDSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVTHPGGPKIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVL...
Function: Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM). Sequence Mass (Da): 37146 Sequence Length: 353 Pathway: Lipid metabolism; fatty acid biosynthesis. EC: 2.3.1.-
Q948R1
MRFSLSPVRPHSVVVPSLPKQDVVSYISGTTSNRQCRCVLTLPSPSVSTSRPPVLPKPETWESLLLNHDQIPGEFSPTGSSIPVKLGRRWMEYQGLQNWDGLLDPLDDNLRREILRYGQFVESAYQAFDFDPSSPTYGTCRFPRSTLLERSGLPNSGYRLTKNLRATSGINLPRWIEKAPSWMATQSSWIGYVAVCQDKEEISRLGRRDVVISFRGTATCLEWLENLRATLTHLPNGPTGANLNGSNSGPMVESGFLSLYTSGVHSLRDMVREEIARLLQSYGDEPLSVTITGHSLGAAIATLAAYDIKTTFKRAPMVTV...
Function: Sn-1-specific phospholipase that releases free fatty acids from phospholipids. Low activity on galactolipids and triacylglycerols. Catalyzes the initial step of jasmonic acid biosynthesis. Not essential for jasmonate biosynthesis after wounding or upon pathogen infection. Catalytic Activity: a 1,2-diacyl-sn-g...
Q9MA46
MAAKVFTQNPIYSQSLVRDKTPQQKHNLDHFSISQHTSKRLVVSSSTMSPPISSSPLSLPSSSSSQAIPPSRAPAVTLPLSRVWREIQGSNNWENLIEPLSPILQQEITRYGNLLSASYKGFDLNPNSKRYLSCKYGKKNLLKESGIHDPDGYQVTKYIYATPDINLNPIKNEPNRARWIGYVAVSSDESVKRLGRRDILVTFRGTVTNHEWLANLKSSLTPARLDPHNPRPDVKVESGFLGLYTSGESESKFGLESCREQLLSEISRLMNKHKGEEISITLAGHSMGSSLAQLLAYDIAELGMNQRRDEKPVPVTVFSF...
Function: Sn-1-specific phospholipase that releases free fatty acids from phosphatidylcholine. Has a higher galactolipase activity than phospholipase A1 activity when digalactosyldiacylglycerol (DGDG) is used as substrate. Catalyzes the initial step of jasmonic acid biosynthesis. Required for the biosynthesis of basal-...
O23522
MQTLTPNADIFHAKRRRFTCNTHTSTLIPTKPLSVSPARKTNKEHLRNLENVLRTSSNSIDHIENVTSRQEKTTKNTSTSSLLGGLNLARIWPQMKAAVDEMSPKNLKRLQRLLSKSSEERSPKSKLGSKWRELHGLNNWAGLLDPLDENLRRELVRYGEFVQAAYHAFHSDPEGSPRHVALPDGSFKVTKSLYATSSVRLPKWIDDVAPDLRWMTKQTSWVGYVAVCDDPREIRRMGRREIVIALRGTATLLEWSENFRPNLVSMPEPKPDQSDPTRPKVECGFNSLYTTGDQHAPSLAESLVGEISRLVELYAGEELS...
Function: Acylhydrolase that catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position. Has a strong galactolipase activity toward digalactosyldiacylglycerol (DGDG). Hydrolyzes triacylglycerol (TAG), but has a low activity toward phosphatidylcholine (PC) and monogalactosyldiacylglycerol (MGDG). Sequence Mass...
Q941F1
MATIPSHNLRPHTTNQRTQYSLSFRPHFSRSTLITFPARSSPARAMSRTDEEASISTRLEQESYGLTTAEDIRRRDGEAKESKRLRDTWRKIQGEDDWAGLMDPMDPVLRSELIRYGEMAQACYDAFDFDPFSRYCGSCRFTRRHLFDSLGIIDSGYEVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDNEATRCRLGRRDIAIAWRGTVTRLEWIADLKDFLKPVSGNGFRCPDPAVKAESGFLDLYTDKDTSCNFSKFSAREQVLTEVKRLVERYGDEEGEELSITVTGHSLGGALAVLSAYDVAEMG...
Function: Acylhydrolase with a broad specificity. Catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position. Moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG). May display dual sn-1/sn-2 substrate specificity. C...
Q3EBR6
MAAIPSHNNLLTINHKNSITGSSSLNTNFSEINFPAKFRVATRALSRTDESSLSAVISRLERERRERQGLLIEEAEGAGELWMTAEDIRRRDKKTEEERRLRDTWRKIQGEDDWAGLMDPMDPILRSELIRYGEMAQACYDAFDFDPASKYCGTSRFTRLEFFDSLGMIDSGYEVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDETSRNRLGRRDIAIAWRGTVTKLEWIADLKDYLKPVTENKIRCPDPAVKVESGFLDLYTDKDTTCKFARFSAREQILTEVKRLVEEHGDDDDSDLSITVTGHSLG...
Function: Acylhydrolase with broad specificity . Catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position . Possesses moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG) . Catalytic Activity: 1,2-dihexadecanoyl-s...
Q9C8J6
MASLSLPITLKNPRFFSSSPQNIFKTQPQTLVLTTKFKTCSIICSSSCTSISSSTTQQKQSNKQTHVSDNKREEKAEEEEEEKEVSLREIWREVQGCNNWEGQLDPMNNHLRREIIRYGEFAQACYDSFDFDPHSKYCGSCKYHPSDFFLNLDLHLHKGYTITRYLYATSNINLPNFFQKSKLSSIWSQHANWMGFVAVATDEEEVSRLGRRDIVIAWRGTVTYLEWIYDLKDILCSANFGDDPSIKIELGFHDLYTKKEDSCKFSSFSAREQVLAEVKRLIEYYGTEEEGHKTSITVTGHSLGASLALVSAYDIAELNL...
Function: Acylhydrolase that catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position. Moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG). Catalytic Activity: 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O...
O82274
MVGDIATRWKELSGSSKWKDLLDPLDLDLRRYILHYGDMAEVGYLAFNSDRRSKYVGDSCYTKEELFARTGYLKANPFRYEVTKYIYGTSSIRLPECFIIKSLSREAWNKESNWLGYIAVATDEGKKLLGRRGIVVAWRGTIQLYEWANDFDFPLESAVMVFPGANPNDEPRVANGWLSLYTSTDPRSRFDKTSAQEQVQEELKRLLELYKNEDVTITLTGHSLGAVMSILSAADFLHNEWPKITPSLQHSLCVTVFAFGSPQIGDRSFKRLVESLEHLHILRVTNVPDLIPRYPVFRFTDIGEELQINTLKSEYLKRSL...
Function: Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position. Sequence Mass (Da): 47581 Sequence Length: 414 Subcellular Location: Cytoplasm EC: 3.1.1.-
Q6NYZ4
MAWKWIKAFVYLSVCVTSALGDDEEASASKCADFNNTTWLEYRQATKLQVQYLLLTRKNANCASLFTQDCLNHTQKHTAYFNSSLPTKVIVHGYRALGSKPSWVSGLAQALLREEDVNVLVVDWVYGASFAYNLVVENYKEVAVQISVLINQLTKYGSTLESFHFIGVSLGAHVSGFVGTLFHGKLGRITGLDPAGPMFKSADPFDRLDSSDALFVEAIHTDSDYFGISIPVGHVDFFLNGGMDQAGCARSRFASMYGYVICDHMRALHVYMSALNGSCPLIGFPCSGYEEFLAGKCITCDDPFNGTCPQIGLLKNSGIT...
Function: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid ...
A0A0R4IY06
MDNQQRRTDNMASGETDHLQCVEEPQPGDLIEIFRPAYQHWALYLGDGYIINLTPVDEGQATAVSSVKSVFSRKAVVRMQLLKEVVGADSYRINNKYDDDHTPLPVSEIIQRAQMLIGQEVSYDLLGSNCEHFVTLLRYGEGVSEQASRAIGAISLVTAAASAFSVLGLINTRSRNRPF
Function: Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl gro...
Q9HDD0
MAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY
Function: Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids . Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl g...