ids stringlengths 6 10 | seqs stringlengths 11 1.02k | texts stringlengths 108 11.1k |
|---|---|---|
Q5AVI2 | MAALRASNLLGDPFALATSSIAMLGWLIAFIASIAADVQDPYPSFQWWAIAYSFCCNVGVIVVFLTDTGLTYGVAVVGYLAASLVMNSISANSMFNSKSTSSFQAAGAGFILLCMVNIVWTFYFGSAPQAKHRGFIDSFALNKENQGSYGANRPMSSAYGARPETTTSRPQMYTSAQLNGFETSSPVSGYHGGAPGETRSPSQARFTSLGGPNASNPDTVGEIPPPTEYPYKAKAIYKYEANPEDANEIGFEKGEELEVSDVSGRWWQARKANGETGIAPSNYLILL | Function: Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 30709
Sequence Length: 287
Subcellular Location: Cell membrane
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E1BDF2 | MAPPAGGTAAGSDPGSAAVLLAVHVAVRPLGAGLDVAAQPRRLQLSADPERPGRFRLEMLGAGPGAVILEWPLESVSYTVRGPCQHELQPPPGGPGTLSLHFANPQEAQRWAALVRDATVEGQNGSDSLPPALGPETRPVSPPSPLEVPTPKAPKPKVDLPWSPGDLMEKEELAGRLTRAVEGGDEKGAAQAAAILAQRHVALRVQLQEAYFPPGPIRLQVTVEDAASSAHVSLQVHPHCTIRALQEQVFSEFGFPPAVQRWVIGRCLCVPEHSLAFYGVQRDGDPAFLYLLSAPREAPGRSPQRPQKVDGELGRLFPQS... | Function: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B an... |
Q9H0F6 | MAPPAGGAAAAASDLGSAAVLLAVHAAVRPLGAGPDAEAQLRRLQLSADPERPGRFRLELLGAGPGAVNLEWPLESVSYTIRGPTQHELQPPPGGPGTLSLHFLNPQEAQRWAVLVRGATVEGQNGSKSNSPPALGPEACPVSLPSPPEASTLKGPPPEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPHCTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMD... | Function: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation . LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B a... |
Q91WA6 | MSPPAGGAAVAADPASPVVLLAVHAAVRPLGAGQDAEAQPRKLQLIADPERPGRFRLGLLGTEPGAVSLEWPLEAICYTVRGPNQHELQPPPGGPGTFSVHFLDPEEAQQWAALVRDATAEGQNGSGSPAPAPAPAMCPISPPCSSMAQIPKATQPEVDLPQSSGNFKKEELATRLSQAIAGGDEKAAAQVAAVLAQHHVALNVQLMEAWFPPGPIRLQVTVEDATSVLSSSSSAHVSLKIHPHCSIAALQDQVFSEFGFPPAVQRWVIGRCLCMPERSLASYGVSQDGDPAFLYLLSAPREVSGQSLQNSKMDRKLGLF... | Function: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation . LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B a... |
Q59VX8 | MSRFDYRNTSKNTSVVDPDHSSPIINYRKDAKKGIKFTFMVVGESGTGKTTFINSLLNKKVLNHRYEKLSPTVGDTKTLMFTSAKSVALPNTSILTKNEFNPRTINEEPGIALTETHIEIIDDDNQKLLLNIIDTPGFGENLNNELCFIEIENYLKQQFDLVLAEETRIKRNPRFVDTRVHVMLYFITPTGHGLREIDIQCMKRLSKYVNIIPVIGKADSFTLNELQHFKQQIRIDIQKFNVPTFQFDNSLNDYDEDEDYDLIQECKFLTNLQPFAVVTSEDVFEVRESTTSTKGNNDKPKIIRARKYPWGLVDINDTRY... | Function: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just bef... |
Q07657 | MSTASTPPINLFRRKKEHKRGITYTMLLCGPAGTGKTAFANNLLETKIFPHKYQYGKSNASISSNPEVKVIAPTKVVSFNSKNGIPSYVSEFDPMRANLEPGITITSTSLELGGNKDQGKPEMNEDDTVFFNLIMTHGIGENLDDSLCSEEVMSYLEQQFDIVLAEETRIKRNPRFEDTRVHVALYFIEPTGHGLREVDVELMKSISKYTNVLPIITRADSFTKEELTQFRKNIMFDVERYNVPIYKFEVDPEDDDLESMEENQALASLQPFAIITSDTRDSEGRYVREYPWGIISIDDDKISDLKVLKNVLFGSHLQEF... | Function: Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 min before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck . This collar per... |
A2RV66 | MEFIVLLTVCALLGLSCGQHGEYCHGWTDSYGIWRPGFQCPERYDPPEATFCCGSCGLKYCCSTVESRLDQGLCPNEEDLRDGVPSIELPPTVPTYFPFLLVGSIFVSFVILGSLVGLCCCKCLKPEDDTQVSGPAPIQSRLLDQDPSTDTSRHSSSSSASMPRPPIGARPQNLCSLGAENINLYMNMPPTFPMMGCPQNAQFMHPGTAGPSFMQPPFINYAVPAEHAIIMAPAPYIDARNCYGQTSNIYCQVPQQNDQTVCSGSPSKC | Function: Required for head formation during gastrulation. Functions as an inhibitor for the caudalizing signals wnt and fgf, does not inhibit bmp, activin and nodal signaling in head formation process. Induces retention of fzd8 in the endoplasmic reticulum and inhibits trafficking of fzd8 to the cell surface.
Location... |
D3ZEH5 | MIAWRLPLCVLLVAAVESHLGALGPKNVSQKDAEFERTYADDVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLYQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGELFTFNTTAAQPQYFKYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSQAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENW... | Function: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called g... |
Q38674 | MSDSMSYAVLVAATLFLGIGLQIAWLFFSNFIKRKRLESRISEVSIAIGKNAKNPENEAYVLNYLKEKFSPERFENRITDALGLIISVIHIPLSLLITVWYFAMIAGRIFGFMNIEPVVLWVPMILQLLLSIAIFIFSVFIKIVFGRYPGEANGFNKEFIKTIK | Function: Probably blocks the subsequent transfer of the phage DNA across the inner membrane into the cytoplasm. By this means, P22 excludes superinfection by the phages of the same family and also against DNA coming from oter phages.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 18701
Sequence Len... |
P38396 | MNNSWWQELMRFFLQGMTLKQLIHMLIILIVLIIVMPVSVKEWINLHNPEILPHYWMYYILLFCVSYVLNGVVNSVYHAVTERIEASTAQRRKDREEKVVRDLFDSLTLGERAYLAFAVAANNQLKTEKGSPEAISLLKKGIITRLPSAIGYPDIDRFIIPEKYFNECYMRFAGKSDILMNELIVQDEQLKK | Function: Has a role in the prevention of superinfection by phages that are insensitive to repression.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 22443
Sequence Length: 192
Subcellular Location: Host membrane
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P03762 | MMSIEMDPLVILGRVFSNEPLERTMYMIVIWVGLLLLSPDNWPEYVNERIGIPHVWHVFVFALAFSLAINVHRLSAIASARYKRFKLRKRIKMQNDKVRSVIQNLTEEQSMVLCAALNEGRKYVVTSKQFPYISELIELGVLNKTFSRWNGKHILFPIEDIYWTELVASYDPYNIEIKPRPISK | Function: Has a role in the prevention of superinfection by phages that are insensitive to repression.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 21557
Sequence Length: 184
Subcellular Location: Host membrane
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O74446 | MSNRIGPQRSTKTAAKLRLLPSTEEFDDFRRQDTGREVYSQIPQIEGSTAKRDAEHLGKRHREFLPRVTAYCTCDTFRVDLLFKFFQSRRSSHKTRPKQFDECIYSPYSYNNEETTDLLPDTLESSRGTLNRESSQESLQSIFEESGLDRNQPLFREVFCFTYGVVVLWGYTIDEEHRFLRELGRFEIEKLKIEDMEVEEFNYYITTLYQPRIFNDFIALRDASNYMIRLSISHAIAQSVKISLFEELVNETIDATKDTPQMIAETGRVNLKREEIMMAVGQLFILRININLQGSVLDSPELMWTEPQLEPIYTAARSYL... | Function: Required for sporulation where it is believed to have a role in meiotic nuclear division.
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 44642
Sequence Length: 382
Subcellular Location: Nucleus membrane
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P38262 | MSITSEELNYLIWRYCQEMGHEVSALALQDETRVLEFDEKYKEHIPLGTLVNLVQRGILYTESELMVDSKGDISALNEHHLSEDFNLVQALQIDKEKFPEISSEGRFTLETNSESNKAGEDGASTVERETQEDDTNSIDSSDDLDGFVKILKEIVKLDNIVSSTWNPLDESILAYGEKNSVARLARIVETDQEGKKYWKLTIIAELRHPFALSASSGKTTNQVTCLAWSHDGNSIVTGVENGELRLWNKTGALLNVLNFHRAPIVSVKWNKDGTHIISMDVENVTILWNVISGTVMQHFELKETGGSSINAENHSGDGSL... | Function: Antagonizes telomeric silencing in yeast. May recruit SIR4 to non-telomeric sites or repression.
Sequence Mass (Da): 59161
Sequence Length: 535
Domain: The LisH domain mediates tetramerization and interaction with SNT1.
Subcellular Location: Nucleus
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Q8IN35 | MMAASGRIRKRKHKSHTSGDVPSTTTSVPMPIPTMAPGKMVAETMEEAAALAGDYNNFTHNFVDLQNLLSFNELNGTSGSGGTAVSSLGSSSAIKLNNSAITDTLLGTVLTTATATVAPAASSLLATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKR... | Function: Receptor for the neuropeptide SIFamide . Modulates sexual behavior by playing a role in male sex discrimination . Also involved in promoting sleep .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 83442
Sequence Length: 758
Subcellular Location: Cell membrane
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Q56061 | MPITIGNGFLKSEILTNSPRNTKEAWWKVLWEKIKDFFFSTGKAKADRCLHEMLFAERAPTRERLTEIFFELKELACASQRDRFQVHNPHENDATIILRIMDQNEENELLRITQNTDTFSCEVMGNLYFLMKDRPDILKSHPQMTAMIKRRYSEIVDYPLPSTLCLNPAGAPILSVPLDNIEGYLYTELRKGHLDGWKAQEKATYLAAKIQSGIEKTTRILHHANISESTQQNAFLETMAMCGLKQLEIPPPHTHIPIEKMVKEVLLADKTFQAFLVTDPSTSQSMLAEIVEAISDQVFHAIFRIDPQAIQKMAEEQLTT... | Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells.... |
Q96LC7 | MLLPLLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGR... | Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to a... |
Q80ZE3 | MSLLLFLLSFLLDGPQGQMESYFLQVQRIVKAQEGLCIFVPCSFSSPEGKWLNRSPLYGYWFKGIRKPSLSFPVATNNKDKVLEWEARGRFQLLGDISKKNCSLLIKDVQWGDSTNYFFRMERGFERFSFKEEFRLQVEALTQKPDIFIPEVLEPGEPVTVVCLFSWTFNQCPAPSFSWMGDAVSFQESRPHTSNYSVLSFIPGLQHHDTELTCQLDFSRMSTQRTVRLRVAYAPRSLAISIFHDNVSVPDLHENPSHLEVQQGQSLRLLCTADSQPPATLSWVLEDQVLSWSSPVGSRTLALELPWVKAGDSGHYTCQA... | Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid . The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibi... |
Q60670 | MVIMSEFSAVPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADPTLLQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGIDRQ... | Function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key ... |
Q9IA88 | MVIMSEDASVPAPSAAQPRPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNLEKIYREVQIMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFWQILSAVEYCHSHHIVHRDLKTENLLLDANMNIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPHLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPYFMSEDCETLIRRMLVVDPTKRITISQIKQHKWMQADPSLRQQQSLSFSMQNYNSNLGDYNEQVLGIMQTLGIDRQR... | Function: Phosphorylates IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).
PTM: Phosphorylated at Thr-181 by STK11/LKB1 in complex with STE20-relat... |
Q8CFH6 | MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRTTKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDLKAENLLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLIEVPVQRPILYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTVESLQN... | Function: Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism . Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction . Inhibits CRE... |
Q84K34 | MARFSVCGGDDGEGPSNNNHQSRKRQRLPSIDENEEDAETSDAGSSGEEDEDETQNQGMRPESEDRGSTSDDSDREVVIEERRFGKFVNSQSSSSSKDSPLSVTLLDPDVLDCPICCEPLKIPIFQCDNGHLACTLCCTKVRNRCPSCTLPIGYVRCRAMEKVIEASRVSCLNAKYGCKESTSYGNRFSHEQVCVFTPCSCPILDCHYTGYYKDLNNHVRAEHKDDLISFVWNTRLTISLDLNKKTTILQEENDGHVIVVQVFRALHAVYVSVSCIAPLTPGVGRLSCRLAKITVDSLLKQGFMVKNIQKVTNEHPEDGF... | Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers th... |
Q9FM14 | MEDSNSHPQNQTSKRKSSHPQKKQRMENETRSAKLLDLDVLDCPVCFEPLTIPTFQCDDGHIVCNFCFAKVSNKCPGPGCDLPIGNKRCFAMERVLESAFVPCQNTEFGCTKSVSYEKVSSHEKECNYSQCSCPNLECNYTGSYNIIYGHFMRRHLYNSTIVSSKWGYSTVDVLINIKEKVSVLWESRQKLLFVVQCFKERHGVYVTVRRIAPPASEFKKFSYRLSYSIDGHNVTYESPEVKRLLEVNSQIPDDSFMFVPNCLLHGFLIKPANEVQQVTIAQETVMEDPPTSLFKNSVPIREDQIQNAITNSIR | Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers th... |
P59941 | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLMWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVAKTRGLRACRGELRDTILDWEDSLPDRDLMLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLRIHGYVDEVMCRLMKHLGLEIPAWDGPCVLDKALPPLPRPVALKAEPPVHLNGAVHVSYKSKPNSPIL... | Cofactor: Binds 1 zinc ion per subunit.
Function: NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging . Displays protein-lysine deacetylase or defatty-acylase (d... |
Q9VAQ1 | MEKDLGEEKDQDQEQNTEMEPKQEMDVAQSYITRAKMNPAKKDNEKRRRKDAMRRVSMILRKCDSMRTTEDRQFLEKHPDMVKTTKKRKERVEIYKERVVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQKGQDIGEHDLSSANPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRPNSVYWRQFDTTEMTARYCHKTHRLCHRCSEPLYDTIVHFGERGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYTWLWQMDRPARQRAKICVV... | Cofactor: Binds 1 zinc ion per subunit.
Function: NAD-dependent protein deacetylase.
Catalytic Activity: H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
Sequence Mass (Da): 88469
Sequence Length: 771
EC: 2.3.1.286
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Q9NRC8 | MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMR... | Cofactor: Binds 1 zinc ion per subunit.
Function: NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase, deglutarylase and dedecanoylase), depending on the context . Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) . In contrast to o... |
B2RZ55 | MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVM... | Cofactor: Binds 1 zinc ion per subunit.
Function: NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase, deglutarylase and dedecanoylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to oth... |
O00241 | MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTC... | Function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP .
PTM: N-glycosylated.
Location Topology: Single-... |
P0A238 | MTIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIVKTHILPFTESGSWLTEKLFGVIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKLATTKIPLLG | Function: Required for maximal expression of sirC, not required to invade host cells.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 14467
Sequence Length: 129
Subcellular Location: Cell inner membrane
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Q84JH7 | MTTQSQFLVNLSYGGLASQSNLRANNRVSPSSCQITRTNRSWALPVSFKVEKFQLQRGRRRRGSPCFGESEGLVKNGIGDADGIIIVDHGSRRRESNLMLEEFVKMFKEKTGYPIVEPAHMELAEPSIKDAFSLCVQQGAKRVVVSPFFLFPGRHWHTDIPSLTADAAKEFSGISYLITAPLGPHNLLLDVVNDRIQHCLSHVEGDADECLVCAGTNKCKLYNSS | Cofactor: Binds 2 [4Fe-4S] clusters per dimer. The [4Fe-4S] cluster quickly oxidizes to a [2Fe-2S] form in the presence of oxygen.
Function: Chelates iron to the siroheme precursor. Catalyzes the last step of the siroheme biosynthesis. Unlike its counterparts in bacteria, contains an [Fe-S] cluster which is not involve... |
Q86WV1 | MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQRGDL... | Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling ... |
Q3UUV5 | MQAVALPEEICWLLEDTEDFLAEGLQNENLSPGAQDQRAHILRGFQQIKSRYCWDFQPQGGDLGQDGSDDNLSGTHGPPLTSEASFWSDYQDEGIEDILRGAQELDSVIKQGYLEKKSKDHSFFGSEWQKRWCVISRGLFLYYANEKSKQPKGTFLIKGYSVRMAPHLRKDSKKESCFELISQDRRSYEFTASSPAEARDWVDQISFLLKDLSSLTIPFEEEEEEEEEEEKEEEEMYNDVDGFDSPRSGSQCRAMALPEPTEKEEDIYEVLPDDDDLEEDTCGAHRRRVDYADYYQGLWDCHGDQPDELSFQRGDLIRIL... | Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglob... |
Q1KKW7 | MEAVDLLANVSVTGLLLFWGDCEFFVSEILYDENLSENAQETRKVLLNNFRVVHVRNPQEFPFPSDYKEEDGSDDNRSSSLGRSAQSDDASLASDNQDDGIPEYFGDIPPVAAQDIVNVLKQGYLEKKRKDHSFFGSEWQKRWCVLNNLVFYYFGSDKDKQQKGSFYISDYSVQLVTNLRKDSRKTSCFEFFAPGRRPFQFTAGSPQEAKEWVDQIKIVLRDLSSTVIPVDDEEEEEEEEETYDDIEGEGGPPLPQPLSGTWGRGGDTGAADEEDEDIYEVLPEESPDSADGSMERNNKPEYANYYQGLWDCSADEPDEL... | Function: Positively regulates T-cell receptor signaling. Required for optimal conjugation between T-cells and antigen-presenting cells (By similarity).
PTM: Phosphorylated on tyrosines.
Sequence Mass (Da): 41279
Sequence Length: 363
Subcellular Location: Cytoplasm
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Q6DII7 | MQGYDIPRDVISLLKDAETYLAECLQNEKLSGRAREQRDEILHSFGQIRNRYGVEFALKGGEAAFTHTGQDDYDDIHNASYAPSQASDEVSVASDYVENDSEVEEELDKIFKQGYLERRKKDHGFFGSEWQKRWCVLTTRAFLYYSSEKGKQPKNGFLIKDSLAQMMPYIRKDSRRDSCFEVVTPNQQVFQFTAASPSDARDWVEQIQFLVKDTQSTIIPYEDDEETYDDIESTESSPVVGLTNDSENSLQEDDVYESIPGDEETEESEDENYEMKPGEPVIFYGDYYQGLWNCFSDNSDELSFERGDLIHILSKEYHAY... | Function: Positively regulates T-cell receptor signaling. Required for optimal conjugation between T-cells and antigen-presenting cells (By similarity).
PTM: Phosphorylated on tyrosines.
Sequence Mass (Da): 39737
Sequence Length: 345
Subcellular Location: Cytoplasm
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Q12505 | MLSDCLLNNFRITAQIGSGAYGLVFHVVDILTSREYAVKTVFKSSSMDEFYNKNGLNNNSQVARTTLLQTQLYHFFKSFQKKLFLPSVDLDSILQLTENELNRLPHYREIAFQLRVQSHGNIVKIHQVLESSIATFIVMDYYDRDLFTSIVDDKHFVNHGILIKKVFLQLCSALDHCHRLGIYHCDIKPENVLLDRNDNAYLCDFGLSTKSKYLAPNVCVGSSYYMAPERILYCLNTTTNGIHVDECCSSLPTDTGDIWSLGIILINLTCIRNPWLKAHQKEDNTFQHFANDNNVLKKILPISDELFTVLTKILQLNPYT... | Function: May have a role in glucose regulation.
Catalytic Activity: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
Sequence Mass (Da): 57844
Sequence Length: 502
EC: 2.7.11.1
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Q92581 | MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAM... | Function: Endosomal Na(+), K(+)/H(+) antiporter . Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaini... |
Q96T83 | MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATEKEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAF... | Function: Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH.
PTM: N-glycosylated.
Location Topology: Multi-pass membrane protein
Catalytic Activity: H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)
S... |
Q5ZJ75 | MAEFANASHEVINVTLGTTLAATTKLVMPTPAKPILPVQTGVQAQQEEQSSGMTIFFSLLVLAICIILVHLLIKYRLHFLPESVAVVSLGIIMGAFIKIIEAQKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFSVFGTAISAFIVGGGIYFLGQADVIYKLNMTDSFAFGSLISAVDPVATIAIFNALNVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRENMSDVSGWQTFLQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFS... | Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).
Location Topology: Multi-pass membrane pr... |
Q9Y2E8 | MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSG... | Function: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry . Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal mor... |
Q8IVB4 | MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDAAAFFQSVGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLS... | Function: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and co... |
Q49UX4 | MRKKIIATVIGTSALAAVTWTNADAATTYKVKSGDSLWSIANKYNMSVAKLKSLNNLTSNVIFPNQSLKVSGSTSSSTSSNTSTGSTYTVKSGDTLSGIAAKYGTTYQKIMSLNGLSNFNIYPGQKLKVSGAASSSSSNTSGNTSSGSTTTYTVKSGDSLSAIAAKYGTTYQKIMSLNGLTNFNIYPGQKLKVSGKASTGGSGSSSTGSAGYKTPVFNHSNLYDWGQCTWHVFNKRAQIGKGISTYWWNANNWDTAAAADGYTIDRKATVGSILQSDMGYYGHVAFVESVNANGSITISEMNYSASPGIVTYRTIPASQV... | Function: Peptidoglycan hydrolase involved in the splitting of the septum during cell division.
Catalytic Activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
Sequence Mass (Da): 34491
Sequence Length: 327
Subcellular Location: Secreted
EC: 3.5.1.... |
Q8ZQQ2 | MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAYADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKDAVNYELIWSEWVKEAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP... | Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (thioredoxin). Leads to significant decrease of thioredoxin activity ... |
Q4E4I4 | MVLMGPHSALRLLPLKTQAIRFVLLLLLSVLILAVALLVTNARMPDPKVVRPLPDIGFEVFPKVGWLEHLTDVCIFILNFLSLLVVFKLYLLHRQNEGLDELQPFSCCPLIGKIIFGVWDSGRQSGIEKRDAHLIAWIRYFTTYFIVLLFRAIVVVMTSYPATDNHCQNPMKITNPVKNVIMTLVTFGSGSIHCGDLMFSGHTVSITLSLLVQWIYGSMLHWVFRPASVLLVLLSFYSIIASRSHYTDDILVSFYITVTTFLVLRHSPDGAPWQLQLLIGWWPCCVSNEETEDSDRNPTFVAVEVFLPHGDYQCAERISE... | Function: Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors. Essential for viabil... |
Q05047 | MEMDMDTIRKAIAATIFALVMAWAWRVLDWAWFTPKRIEKRLRQQGFRGNPYRFLVGDVKESGKMHQEALSKPMEFNNDIVPRLMPHINHTINTYGRNSFTWMGRIPRIHVMEPELIKEVLTHSSKYQKNFDVHNPLVKFLLTGVGSFEGAKWSKHRRIISPAFTLEKLKSMLPAFAICYHDMLTKWEKIAEKQGSHEVDIFPTFDVLTSDVISKVAFGSTYEEGGKIFRLLKELMDLTIDCMRDVYIPGWSYLPTKRNKRMKEINKEITDMLRFIINKRMKALKAGEPGEDDLLGVLLESNIQEIQKQGNKKDGGMSIN... | Function: Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. secologanin) biosynthesis pathway. Catalyzes the conversion of loganin into secologanin . Catalyzes the conversion of secologanin into secoxyloganin .
Catalytic Activity: loganin + O2 + reduced [NADPH--hemoprotein reducta... |
B3A0M2 | MISYPFFSLSPPGLVPPPMAVPPVEMYSGSFWNRMRKPLPLRTQVIRFTVVFVIVSFILAVALQITHERMPDPKVTKPLPDLGFELLTKVPGMYVLADCCIGFLNILSVFTAFKLYLLHRHCVGSGEPELPCNIPGVSRFFLSVWLCKENCRIELRNIHTIAWIRFITSYALLLLFRSAVIVMTSLPAPDDLCQDPPKIENPVKNVILTVLTAGGGSIHCGDLMYSGHTVILTLHLMFHWIYGAMVHWSFRPVVTVVAIFGYYCIVASRFHYTDDVLVAIYLTIATFIAVGHNADGAPWQLQLFIRWWPCCGANSREVTE... | Function: Bifunctional sphingomyelin (SM)/ethanolamine phosphorylceramide (EPC) synthase with minimal inositol phosphorylceramide (IPC) synthase activity . Specificity is likely to be defined by residues in the lumenal catalytic domain that interact with the polar head groups of the phospholipid donors . SM is synthesi... |
Q0UAL6 | MSEALKIESRPIPAFYCCYLLRSKNRKSYYIGSTPNPARRLGQHNGSSKGGAKRTSMQGKRPWEMTCIVTGFPSKFAALQFEWAWQNTHATRHIDKDVRDARAEELQKGKKKATSPGRRRKRPPMSLEARLKNLHHLLSVDSFCRWPLNLRFFAPDVFVQWERHTTKMTTTLRKSITIQLTPAEIPKLASDVSTELQTHFIPEVIRAIPVAYEDCKQYIEKSRRVLEDDQRLGCGVCKNPADMSSSLILVCPIEACQTVSHLSCLSNKFLTEGGELETLVPLEGTCPGCRSCIKWATMIKELSLRTNGEEELKLLFKPKR... | Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 4... |
A5DFX7 | MAPTQIFVSPEFYGVYILQSEPSPRSFYIGSTPDPIRRLRQHNGDLKQGAFRTRRTSRRPWKMIAITHNFPSRVAALQFEHALQHPKTSRHMAGGGGSVTATAETAKSAPVAGKSDATSPAKNRRNAAPVARSGRTHLRNVARLLESPYFSRMGLKVTIFDPSLFDMDLLPAQLQSFAAFSGARTAACSDYFSVAKKAALTTAHCCLCSDAIDYVPEMLPESIKDVLLVLPLIAVCPSCAVICHLRCLAASWYQSSEINAALIPSDVSCSQCGAQTSWRLVADMATKLRQYALSS | Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 3... |
A3LZG5 | MPRRPSTGTQSDTPALHVVPSFYGVYLLQSEPKPSSFYIGSTPDPPRRLRQHNGDLKAGGAYRTKRAGFRPWRMLLVVYDFPSKVSALQFEHSFQHCHETRHIKQEERISKNKLSGRTLHHKVANVALLLRSSYFRHLPLKVLVFEEAVYNSFMNNKFVTCSHVDLLNTNFNEYFSVMEKDLDSTVDSWKTRHTNENEIWSMAKEAVILGSPRCALCLEPIEQVPETSSPISKRSDLQRYLQSESLPLVTMCYNPQCRDVFHLSCLGHRFTNSDGFQSLIPATVNRCCSCNAKLEWRTLAKIATKLRYYVLKDSLQLPSQ... | Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 3... |
B2WM34 | MTDGLKIDSRPLPAFYCCYLLRSKNRKAFYIGSTPNPARRLGQHNGSSKGGAKRTSMQGKRPWEMTCIVTGFPSRFAALQFEWAWQNTHATRHIERDVREARKDELEKGRKNASPVKRSRPPMSLEARLKNLHHLLGVGSFSRWPLHVRFFAPDVFSQWEKHISKMNTSLRKSITIRLTPAELPKLAPDVSSEMRTHFIPEVIRAIPVAYEDIKPYVEKSMSTLRDGKTRDCGVCKKDVNVDRSLVLICPNETCCSVSHMSCLSQRFLAEEANKEAFIPIEGTCPSCHSPIKWSDMIKELSLRMRGEDELKTLFKTKRKK... | Function: Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 4... |
B6JY16 | MFYCCYLLVSEKAASRSVYIGSTPDPARRLRQHNGEIKGGAYKTKRSRPWKVACFVHGFPTKIAALQFEWVWQHPQSTRHDDLRQHSRVVSVKRQTLLSCVRALGVMLCCEAWSRWGLRVAIFDDAVHRLWLKERLPSNCIQLCSFDDVESLRLADYGGDAGWLDTQRKKRAQLSVQAQCSICVRAILLPCFFLCCPFPDCRMIAHSTCLAASFLQEAQDDEHILPISGTCARCKRLLSWKLLVQASLSPSDEDNGAVGDTGESDDNNERESS | Function: Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 3... |
Q9P7M3 | MDLCNFYCCYLLKSNRTQSSGAVYIGSTPDPPRRLRQHNGEIVGGASKTKHGRPWSISCLVYGFPNKVSALKFEWNWQNLGISRYTKDCDFRSKKQKTIMYCLKGLKHLVDSDTWRRWPLNITFLNKTAFSKWNQLGKTYGNINVYFDEEWLNGFHEKVIQKTYDHKLCLRKTISEPVKCNLCYECIESDELRANCPFTDCNSINHLTCLASSFLTEECQVLPIEGMCTKCKRVLRWREFLSTVFTTSLETDERDFESENRIEIIDLELEK | Cofactor: Divalent cation. Mg(2+) is preferred. Has Holliday junction resolvase activity solely in the presence of Mn(2+).
Function: Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards ... |
B8MDD1 | MTTTVSEEAVLTKPIPAFYCCYLLRSAKRPSALYIGSTPDPARRLEQHNGFAKGGAKRTERNTLRPWEMVAIVEGFPSRTGALQFEWSWQHVHTTRHIGAVETDQLNRKRKNPPTDKGSGIWTSTPKVLGNLHQLLRSTYFGTWPLTVRFLSSEAHNHWQRWIERADGLLPDTIRVKLDFRAEGASVLDSNLPANDMTHIDATYGGIQEHLAKSTSLLGDNTNSLSCEVCQQQLSTQTEIIVVCSHRRCHAVFHVNCISQLFLEDEGSSGLVPILGECPACRQEVTWVELMKELSMRLHGGKNATKLLKGERKDKANTQG... | Function: Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 4... |
Q57XV5 | MDTRFHCVYLLTSLDPQCEGAHYIGYTVNPIRRLRQHNGELVNGARRTKRNGRPWLLLMCVSGFGEDRIALKFEWCWQNPSKSTRLKSHVSQLRCVHKLTHAVGVLLLLLRTELFSRLQLTLHIFDREHFDKVISQLLSALPTMEPLVETSLLRVESTTIEQFQTQYMNDGQWGAAVDYGAYFMRAPPGANVDVSKPIVGGQDNTLRCGVMHNNLCEEEVIRQHVKERTLLESGHYPCSLCSLPLRAPYFLRCSRTPFCRLRAHIVCLAMWFIYDSSQRGGDPLVKDAGPAEVAENSNDAACQVNENCYSLSGCGPVVGG... | Function: Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da):... |
Q4PDF6 | MPSSVTKHTIPPFYACYFLRSLSTPGTTYIGSTPAPPRRKRQHNGHLTQGAYKTSRARPWEMECIVYGFSSKIAALQFEWAWAKPHLSRHLKFLTTEHSVDGTPKNTSDWAGMSLFPSTSLTPGQTRWGRPKKRMARPPSSPNARLLAMRALLRSEPFCGWGLKLAFFTEWSWLAYQRLDACDPGLVAKSALSTLQNRYSRSGKPLHALYPVAVCDFSGVDGKREPLVHVSEPYRLDAGVAEHPVKKRQTSSRQKPHTEETSAWPETLPRSANLKGLDACMQDFATFPIPQPAAPNTDLTKKSKRAKKLSDKARPSALED... | Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 7... |
A7TTE6 | MMNSSQFSDSQTTSLHRIPTFYCCYLLQSINKKQSFYIGSTPNPVRRLRQHNGNLSNGGAYRTKREGTRPWEMVLVVYGFTSKIAALQFEHAWQHGYKTHYIPMDDRIMKNANSGRTVHHKLGLVRQLLANVYFRHMNLKVHFFSMPILDVWNLNKFNIKMGSNEISVDVSQVSQETKTNLEQASDDDDDNGACSRDERNLQLVTELYDNTVTKENEIKEIIKDILVLGERNCNLCGQCYDYTSEDDTMKMHIFICPNSTCHYEAHLNCLYEKFIEEESGIDSKNILLPNFCMCPGCLDEMSWSDFVKISTMIKNSFSN | Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 3... |
Q0IH86 | MVVEVEGFYGVYLLFCTNPKYKGRIYIGFTVNPERRIQQHNGGKHKGGAWKTSGRGPWDMVLIVHGFPNDIAALRFEWAWQHPHVSRRLTHVPRKTKKQSSFDFHLLVLCHMLRVAPWNRLPLTLRWLRQEYRRELPLLLQPPLHMPLAFGQVRARPIPKGEKEKGRLGENRAEETEQEVILLGDAVVQRCRVCYERVQDKDDSLHCFHPGCTLTAHIMCLAKLFLLNEPQNLIPVEGLCPSCGHSLLWGDLIRHRNGCYGDLEEISSSQAHWGDELHRCSD | Function: Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 3... |
Q6C0W7 | MTHQYPPFYGVYLLQSTKKPLSCYVGSTPNPFRRIRQHNGDLKAGGAWRTKRAHLRPWSMVLIVNGFPSKISALKFEHALQHPNMTRLITTKDIKRKVPQKARALGTHLAFIRLLVRCSYFRRMHLRITFFRSHAHEAWEKNDYDVGSLPPQFQVETDYPSDEAEAPPSTVGSGELDINNRSIEEYLQKCRDAVSNDKQLTCYLSEKTLNISEGNVALCHNCDGAFDVAELAERFLNEEIPEELPFTTPSRHIIPIGGDCPSCLARMEWSNVIKGVLAMRPVLEDNKE | Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Sequence Mass (Da): 3... |
P38324 | MSQKIQQHQFPDFYCCYLLQSINKRQSFYVGSTPNPVRRLRQHNGKLAVGGAYRTKRDGSRPWEMIMIVRGFPSKIAALQFEHAWQHGYQTHYIAEKDRVVKHKAGGRTLHHKVALMKLLLKHEFFQRMNLIVEVFNIKAWEVWKQDKFFIERDRFPINIQINENALEEPKEKTVDVLMDHSDENLKVVEAVYTKVIENERNIFETFEKKLTTGVVRCEICEKEIDYTSEEQNLKPFVALCNNKDCGCVNHLKCLHRYFLDDEQLMVGRRNLIPRGGKCPKCDMFCDWTTLVKFSTRMKLAHGK | Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for ... |
P84022 | MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNC... | Function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the S... |
Q13485 | MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAP... | Function: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts sy... |
P97471 | MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPE... | Function: Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA a... |
P97454 | MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNAPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMAPDNSQPMDTSSNMIPQTMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRN... | Function: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis . Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates wit... |
O43541 | MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDAS... | Function: Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta . Acts as a mediator of TGF-beta and BMP anti-inflammatory ac... |
O35182 | MFRSKRSGLVRRLWRSRVVPDREEGSGGGGGVDEDGSLGSRAEPAPRAREGGGCSRSEVRSVAPRRPRDAVGPRGAAIAGRRRRTGGLPRPVSESGAGAGGSPLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFTAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPPDQYKPLDLSDSTLSYTETEATNSLITAPGEFSDA... | Function: Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (By similarity). Acts as a mediator of TGF-beta and BMP anti-... |
O15105 | MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCG... | Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access . Functions as an adapter to recruit SMURF2 to the TGF-be... |
P61278 | MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC | Function: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.
PT... |
Q9LM02 | MDLASNLGGKIDKSDVLTAVEKYEQYHVFHGGNEEERKANYTDMVNKYYDLATSFYEYGWGESFHFAQRWKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLTTKCLEALKQAGFEVIWEKDLAKDSPVPWYLPLDKNHFSLSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGR... | Function: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol.
Catalytic Activity: cycloartenol + S-adenosyl-L-methionine = 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 38268
Sequence Length: 336
Pathway: Steroid biosy... |
Q54I98 | MNTQQRAMEGDLSRIVAISRKEKDAVSRNDKVDDTLNGYKELFKGNDDKAIQARKNNYTHMVNTFYDLATDFYEFGWGQSFHFATRHKYESFEASIARHEMYMAHQLGLFPGMKVIDIGCGVGGPMRTIARFSGANVVGLNNNEYQIQRGKRLNESAGLSHLCSFIKADFMHVPVEDNTYDCAYQIEATCHAPDLVGLYKEVFRIVKPGGLFGGYEWIMTNKFNPEDPVEVNIKKQIELGNGLPDLVKPAEIINAAKAAGFEVITAFDVAETSELPWYLPLSSGVSITGFLHTGVGRYLTGKFTQLLEIVKLAPAGSYNT... | Function: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol.
Catalytic Activity: S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 39559
Sequence Length: 354
Pathway: Steroid biosynthesis; sterol ... |
Q39227 | MDSLTLFFTGALVAVGIYWFLCVLGPAERKGKRAVDLSGGSISAEKVQDNYKQYWSFFRRPKEIETAEKVPDFVDTFYNLVTDIYEWGWGQSFHFSPSIPGKSHKDATRLHEEMAVDLIQVKPGQKILDVGCGVGGPMRAIASHSRANVVGITINEYQVNRARLHNKKAGLDALCEVVCGNFLQMPFDDNSFDGAYSIEATCHAPKLEEVYAEIYRVLKPGSMYVSYEWVTTEKFKAEDDEHVEVIQGIERGDALPGLRAYVDIAETAKKVGFEIVKEKDLASPPAEPWWTRLKMGRLAYWRNHIVVQILSAVGVAPKGT... | Function: Catalyzes the methyl transfer from S-adenosyl-methionine to the methylene group of 24-methylene lophenol to form 24-ethylidene lophenol.
Catalytic Activity: 24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine
Sequence Mass (Da): 40450
Sequence Length... |
Q94JS4 | MDSVALYCTAGLIAGAVYWFICVLGPAERKGKRASDLSGGSISAEKVKDNYNQYWSFFRKPKEIESAEKVPDFVDTFYNLVTDIYEWGWGQSFHFSPHVPGKSDKDATRIHEEMAVDLIKVKPGQKILDAGCGVGGPMRAIAAHSKAQVTGITINEYQVQRAKLHNKKAGLDSLCNVVCGNFLKMPFDENTFDGAYSIEATCHAPKLEEVYSEIFRVMKPGSLFVSYEWVTTEKYRDDDEEHKDVIQGIERGDALPGLRSYADIAVTAKKVGFEVVKEKDLAKPPSKPWWNRLKMGRIAYWRNHVVVVILSAIGVAPKGT... | Function: Catalyzes the methyl transfer from S-adenosyl-methionine to the methylene group of 24-methylene lophenol to form 24-ethylidene lophenol.
Catalytic Activity: 24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine
Location Topology: Single-pass membrane p... |
O43623 | MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYSMPVIPQPEILSSGAYSPITVWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH | Function: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial ... |
O08954 | MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLCESYPMPVIPKPEILTSGAYSPITVWTSAVPFHSPLPSGLSPLTGYSSSLGRVSPLPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQARKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH | Function: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial ... |
Q3KNW1 | MPRSFLVKTHSSHRVPNYRRLETQREINGACSACGGLVVPLLPRDKEAPSVPGDLPQPWDRSSAVACISLPLLPRIEEALGASGLDALEVSEVDPRASRAAIVPLKDSLNHLNLPPLLVLPTRWSPTLGPDRHGAPEKLLGAERMPRAPGGFECFHCHKPYHTLAGLARHRQLHCHLQVGRVFTCKYCDKEYTSLGALKMHIRTHTLPCTCKICGKAFSRPWLLQGHVRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDAKKYRCRRCTKTFSRMSLLARHEESGCCPGP | Function: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).
Sequence Mass (Da): 32474
Sequence Length: 292
Domain: Binds E-box vi... |
Q9QY31 | MPRSFLVKTHSSHRVPNYGKLETLREANGSCSACKELAGSRHLPDEEAPCNPSDPLQPWDSTSAVACISLPLLPNHRETLGVSGPEPQETSWVGPRAAQAPSVTLKDSFTLPPLLVLPTRWPPILGPDGALNEHLRAEGTSRVPGSFECIHCHRPYHTLAGLARHQQLHCHLPTGRAFTCRYCDKEYASLGALKMHIRTHTLPCICKVCGKAFSRPWLLQGHIRTHTGEKPYTCSHCSRAFADRSNLRAHLQTHVGTKKYRCAVCPKAFSRMSLLARHEEAGCCPGP | Function: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'.
Sequence Mass (Da): 31636
Sequence Length: 287
Domain: Binds E-box via C2H2-type zinc... |
Q41358 | MRLVAKLLYLAVLAICGLGIHGALTHPRVTPPVYPSVSFNLTGADTYEPFLRALQEKVILGNHTAFDLPVLNPESQVSDSNRFVLVPLTNPSGDTVTLAIDVVNLYVVAFSSNGKSYFFSGSTAVQRDNLFVDTTQEELNFTGNYTSLERQVGFGRVYIPLGPKSLDQAISSLRTYTLTAGDTKPLARGLLVVIQMVSEAARFRYIELRIRTSITDASEFTPDLLMLSMENNWSSMSSEIQQAQPGGIFAGVVQLRDERNNSIEVTNFRRLFELTYIAVLLYGCAPVTSSSYSNNAIDAQIIKMPVFRGGEYEKVCSVVE... | Function: Neu5Ac(alpha2-6)Gal/GalNAc specific agglutinin . Behaves as a type-2 ribosome-inactivating protein . Strongly inhibits mammalian but not plant ribosomes . The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position ... |
P0CI51 | MNHLILIVAMCLMVIGVQCLKDGYLYDDVDCKFSCWDNEYCRKLCKSKKAVGGYCWRWRFSCYCTGLPDNEKTEGTYKCGQGRFLMGKDK | Function: Binds voltage-independently at site-3 of voltage-gated sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
Sequence Mass (Da): 10446
Sequence Length: 90
Domain: Has the structural arrangement of an alpha-helix connected to antiparallel beta-sh... |
Q948Z4 | MKLFLLTLLLVTLVITPSLIQTTMAGSSFCDSKCKLRCSKAGLADRCLKYCGICCEECKCVPSGTYGNKHECPCYRDKKNSKGKSKCP | Function: Has an antimicrobial activity. Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria.
PTM: Six disulfide bonds may be present.
Sequence Mass (Da): 9664
Sequence Length: 88
Subcellular Location: Secr... |
Q93X17 | MAISKALFASLLLSLLLLEQVQSIQTDQVTSNAISEAAYSYKKIDCGGACAARCRLSSRPRLCNRACGTCCARCNCVPPGTSGNTETCPCYASLTTHGNKRKCP | Function: Has an antimicrobial activity. Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria.
PTM: Six disulfide bonds may be present.
Sequence Mass (Da): 11038
Sequence Length: 104
Subcellular Location: Se... |
P05049 | MIILWSLIVHLQLTCLHLILQTPNLEALDALEIINYQTTKYTIPEVWKEQPVATIGEDVDDQDTEDEESYLKFGDDAEVRTSVSEGLHEGAFCRRSFDGRSGYCILAYQCLHVIREYRVHGTRIDICTHRNNVPVICCPLADKHVLAQRISATKCQEYNAAARRLHLTDTGRTFSGKQCVPSVPLIVGGTPTRHGLFPHMAALGWTQGSGSKDQDIKWGCGGALVSELYVLTAAHCATSGSKPPDMVRLGARQLNETSATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFSEQVRPACLWQLPELQIPTVVAAGW... | Function: Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ... |
Q9VQF9 | MDSDSTVTSLEENTENFCTNPTRDILAEGITNLFKPTIERLDERVASTIQLQAELRGQLDALAAQLRDIEKAQSQIPEFADKVKELLNVKHKVTVISNVLVTSQERLTGLHKLIEKEQRRRQALLDSALSTNIS | Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis . May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 15056
Sequence ... |
O95295 | MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK | Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for... |
E0W3E3 | MKTAEKLGIIGTTISIFGIGFGWGVFPWLIRMQIGRVSLSPGSETREFWEKIPFPIDFKIHIFNITNHVEVQNEGKIPNLQEIGPYYYKEWKEKSEMIDYENDDSITFFMKNTWFDNKEKTLPLTGDEMVIIPNPILVGLITAAEREKKGVLPMINKAIPILFNKPDSVFLKIKVYDLLFGGIIFNCTTKDFSASAVCAVLKKEAPFLETVSRSVFKFSILNQKNGTEEPLKLQIKRGIKDYTEVGKVIGANGKNKLTNWRGRPCNNLEGTDGTIFPSDISEHQDIWSFNLELCRSIPAKFVRKSEYKGIPAFRYNVTIG... | Function: Plays an olfactory role that is not restricted to pheromone sensitivity.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 58606
Sequence Length: 518
Subcellular Location: Cell membrane
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E2IHA6 | MKLPKHLKFAAGAGGAFLFGILFGWVMFPAILKGQLKKEMALSKKTDVRKMWETIPFALNFKVYLYNYTNPEEVQKGGVPIIKEVGPYHFDEWKEKVEIEDHEEDDTITYKKRDTFYFNQEKSGPGLTGEEVITMPHVFMLAMATVVSREKPAMMNMIGKAINGIFDNPADVFIRVKALDIMFRGTMINCARTEFAPKAVCTALKKEAVNGLVMEPNNQFRFSLFGSRNGTIDPHVVTVKRGIKNVMDVGQVVAIDGKPQQDVWRDHCNEYQGTDGTVFPPFLTEHDRLQSFSGDLCRSFKPWYQKKSFYRGITTHRYIA... | Function: Plays an olfactory role that is not restricted to pheromone sensitivity.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 59030
Sequence Length: 522
Subcellular Location: Cell membrane
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D2A0H5 | MRLPVKIAIGCAIGLVVIIVFGFIAFPKMIKGKVKSMINLNKGSEIRQMFVKVPFALDFKIYMFNVTNPMDVQKGALPVLKEVGPFCFEEWKEKVDLDDNDDEDVMFYNPKDTFYKANGPGCLDGSQMITMAHPLILGMVNTVVRTKPGAISLISKAINSIYGNPDSIFMTASAMDILFDGVVIKCGVKDFAGKAVCSQLKEAPDLRHVDENDLAFSFIGPKNATPGKRFKVLRGVKESHDVGRILEYDNKKEMEVWPTKECNQYKGTDGTVFPPYLTKEEGLASYAPDLCRSLVAVYSGDTKYDGIPVRIYTATLGDMS... | Function: Plays an olfactory role that is not restricted to pheromone sensitivity.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 56760
Sequence Length: 514
Subcellular Location: Cell membrane
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C3U0S3 | MMVMNTELRQDTPQFKRWEAVPQPLDFKVYIFNVTNPYEVQMGRRPRVVEVGPYVYFQYRHKDNIRFSRDRSKVHFSQQQMYVFDAESSYPLTENDQLTVLNMHMNSILQIIDTQAKETITNFRSDVNNTLEKIPVVRVIKRIIEKTTPIQSILQLAEDETYDSLRLINAELNRIFGRPDSMFLRTTPREFLFEGVPFCVNVIGIAKAICKEIEKRNTKTIRVQPDGSMKFSFFNHKNMTNDGTYTINTGIKEPALTQMIEYWNGRNTLDRWINQSAGSSSKCNKIVGTDGSGYPPFREGVERMTIFSSDICRTVDIKYV... | Function: Plays an olfactory role that is not restricted to pheromone sensitivity.
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 61707
Sequence Length: 542
Subcellular Location: Cell membrane
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E1JI63 | MIHWSLIVSALGVCVAVLGGYCGWILFPNMVHKKVEQSVVIQDGSEQFKRFVNLPQPLNFKVYIFNVTNSDRIQQGAIPIVEEIGPYVYKQFRQKKVKHFSRDGSKISYVQNVHFDFDAVASAPYTQDDRIVALNMHMNAFLQVFEREITDIFQGFANRLNSRLNQTPGVRVLKRLMERIRGKRKSVLQISENDPGLALLLVHLNANLKAVFNDPRSMFVSTSVREYLFDGVRFCINPQGIAKAICNQIKESGSKTIREKSDGSLAFSFFGHKNGSGHEVYEVHTGKGDPMRVLEIQKLDDSHNLQVWLNASSEGETSVC... | Function: Plays an olfactory role that is not restricted to pheromone sensitivity.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 62634
Sequence Length: 556
Subcellular Location: Cell membrane
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B2RFN2 | MLGKHSKIFFGVSLIFLVIAIVLASWGFQKIVNKQIQKNVQLANDSKMFERWVKLPMPLDFKVYVFNVTNVEEVNQGGKPILQEIGPYVYKQYREKTILGYGDNDTIKYMLKKHFEFDPEASGSLTEDDELTVVHFSYLAALLTVHDMMPSLVTVVNKALEQLFPSLEDAFLRVKVRDLFFDGIYLSCDGDNSALGLVCGKIRAEMPPTMRKAEGSNGFYFSMFSHMNRSESGPYEMIRGRDNVYELGNIVSYKGQENMPMWGDKYCGQINGSDSSIFPPIKEDDVPKKIYTFEPDICRSVYADLVDKRELFNISTYYYE... | Function: Plays an olfactory role that is not restricted to pheromone sensitivity (By similarity). May play a role in the elimination of lipophilic components from the sensillum lymph.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 58629
Sequence Length: 520
Subcellular Location: Cell membrane
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Q17Q87 | MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLTPNGPEVHS | Function: Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation.
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 9396
Sequence Length: 87
Subcellular Location: Mitochondrion outer membrane
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O75324 | MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTPNGPEVHG | Function: Plays a role in the toxic effects of organotins . Plays a role in endosomal maturation .
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 9497
Sequence Length: 88
Subcellular Location: Mitochondrion outer membrane
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P61807 | MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTANSPEVHG | Function: Plays a role in the toxic effects of organotins (By similarity). Plays a role in endosomal maturation .
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 9501
Sequence Length: 88
Subcellular Location: Mitochondrion outer membrane
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Q8MP06 | MFRKFVIMLVLSLLVAAGISQASSASRVCIIGAGYSGLATARYLQDYGLNYTIFEATPNIGGTWRYDPRVGTDEDGIPIYSSNYKNLRVNSPVDLMTYHGYEFQEGTRSFISGNCFYKYMKSFVRHFGLMENIQVRSLVTWVQRTEDKWNLTYMKTDTRKNYTEECDFVVVASGEFSTPKIPHIKGQEEYKGKTMHSHDYKEAESFRGQRVLVIGAGPSGLDVVMQLSNITSKLVHSQHILKSWHIFNQPDFPGNFISKPNVKHFTANGAVFEDDTVEEFDMVIYCTGFYYNHPFLSTLSSGITATENYVMPLYQQVVNI... | Function: NADPH-dependent monooxygenase that detoxifies senecionine and similar plant alkaloids that are ingested by the larvae. Is active towards a narrow range of related substrates with highest activity towards senecionine, followed by seneciphylline, retrorsine, monocrotaline, senecivernine, axillarine and axillari... |
Q03144 | MHKTHSTMSGKSMKVIGVLALQGAFLEHTNHLKRCLAENDYGIKIEIKTVKTPEDLAQCDALIIPGGESTSMSLIAQRTGLYPCLYEFVHNPEKVVWGTCAGLIFLSAQLENESALVKTLGVLKVDVRRNAFGRQAQSFTQKCDFSNFIPGCDNFPATFIRAPVIERILDPIAVKSLYELPVNGKDVVVAATQNHNILVTSFHPELADSDTRFHDWFIRQFVSN | Function: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.
Catalytic Activity: aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O +... |
O15079 | MAMSLPGSRRTSAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDALEASSLLSSGVDCGTEETSLHSSFGLGPRFPASNTYEKLLCGMEAGVQASCMQERAIQTDFVQ... | Function: Inhibits SNARE complex formation by absorbing free syntaxin-1.
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 53537
Sequence Length: 494
Subcellular Location: Membrane
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Q80U23 | MAMSLQGSRRASAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSCKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIRQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGVAKEEGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSNTSAEDGADSGYVAADDTLSRTDALEASSLLSSGVDCGLEEASLHSSFNLGPRFPASNTYEKLLCGMEAGVQVSCMQERAIQTDFVQ... | Function: Inhibits SNARE complex formation by absorbing free syntaxin-1.
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 53753
Sequence Length: 495
Subcellular Location: Membrane
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Q8WVK2 | MGRSRSRSPRRERRRSRSTSRERERRRRERSRSRERDRRRSRSRSPHRRRSRSPRRHRSTSPSPSRLKERRDEEKKETKETKSKERQITEEDLEGKTEEEIEMMKLMGFASFDSTKGKKVDGSVNAYAINVSQKRKYRQYMNRKGGFNRPLDFIA | Function: May play a role in mRNA splicing.
PTM: Phosphorylated in vitro by snRNP-associated protein kinase.
Sequence Mass (Da): 18860
Sequence Length: 155
Subcellular Location: Nucleus
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Q4WWS3 | MQAVPESRQQTFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQDPNWDRNAW | Function: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By... |
Q5A748 | MSKPFQPISDVINTSPKNKSQSFNEIYGEPENFLEIEVKNPLTHGYGSNLFTDYEIVCRTNIPAFKKRESRIRRRYSDFVAFRKILEQETTRVIIPPLPGKIFLNSNKFNDLNIEKRRQGLEKFLIVVSGHPLLQTGSKSLIEFIQNEKWDPKQIIY | Function: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By... |
Q6FT03 | MSGKREFKSFGSTEETMFSQHHKIPSTSEMYAEPENFLEIEVRNPKTHVPNGVDQRGMYTDYEIICRTNLPNFHKRASRVRRRYSDFEFFRKCLLKEISMLNNPRVVVPHLPGKIYLSNRFSDEVIEERRQGLNRWMQIVAGHPLLQSGSKTLIRFIEDDKFVG | Function: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By... |
P0CR61 | MARMAGRPQTFDEMYSVPESFLEIEIRNPMTHGIGRKMYTDYEIVCMTNIPAFKLRHSAVRRRYSDFEAFRDILERESTRVNIPPLPGKVRVFTNRFSDEVIEQRREGLQRFLEIVAGHPLLQTGSKVLCAFLQDPAWDKSQWI | Function: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By... |
Q4I1H6 | MASDQDNSGLDAPGSQFHRPILQSMPDTRQQSFDEIYGPPENFLEIEVRNPRTHGMGRHMYTDYEILCRTNIPAFKLRQSSVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW | Function: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By... |
O60493 | MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA | Function: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By... |
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