ids
stringlengths
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seqs
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11.1k
B6YRV8
MKIRIGFGYDVHPLVMNYNLWLGGIKIPYEKGLKGHSDADVLIHALCDALLGAADIGNIGTNFPNTNKKLRNIDSKILLKQTMSFIYSKNYELNNADITVCIEQPKLNPFIPQMKTCLAEIMQTDKGNISIKATTSEKMGFIGREEGIAVFATVLITPINEIGISCQ
Cofactor: Binds 1 divalent metal cation per subunit. Function: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-meth...
Q1IVA8
MIRVGLGFDSHEFREGIPLRIGGLTIPHTHGLSGHSDGDVLLHAITDALLGAVAAGDIGAFFPPSDPKWKGANSVVFIEEAMRHIETAGYRVGNVDCSLVLNAPKIGPHAKAIQESVAKLLKIEPTAVGIKAKTPEGLNLDGTALAHVVVLLEKR
Cofactor: Binds 1 divalent metal cation per subunit. Function: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-meth...
C5CGG7
MYRVGIGFDAHPLEANKKGLYLGGVKVSEEYSSIGHSDGDALIHAIVDAILGATNAGNIGIWFPENEENRGRRSTEFLEIIRKKILAGKYEILNIDSVIIIDKVRMNPHIENIRLKLARILGISKGNINVKPKSGNTLYGNSVSVYAVCMLKKVGT
Cofactor: Binds 1 divalent metal cation per subunit. Function: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-meth...
Q8F0A5
MYRIGNGIDFHKLEINLNRPLILGGIECESEFALVGHSDADIILHAISDAILGALALGDIGQYFPDTDPSLKNIDSKIILVKCLELMKEKNFDLVNIDCTVIGERPKITPLKDRITKSLSNLLNLPLDCISVKATTTEKMGALGRQEGIGTFCSILLEKRS
Cofactor: Binds 1 divalent metal cation per subunit. Function: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-meth...
Q8YAB4
MIRIGQGYDVHKLAYDRDLIIGGVKIPYEKGLLGHSDADVLLHAITDAIIGAIGAGDIGHFFPDTDMVFKDADSAELLAEIWQKVEADGFRLGNLDATIIAEKPKMAPYVEQMKLRIAELLHADSAQVNVKATTTEKLGFTGREEGIASLAVVLLEK
Cofactor: Binds 1 divalent metal cation per subunit. Function: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-meth...
Q8RG40
MERNTRVVKVANLKIGGNNPIIIQSMTNTNSADVEATVKQINNLEKVGCQLVRMTINNIKAAEAIKEIKKKVSLPLVADIHFDYRLALLAIKNGIDKLRINPGNIGSDENVKKVVEAAKEKNIPIRIGVNSGSIEKEILEKYGKPCVDALVESAMYHIRLLEKFDFFDIIVSLKSSNVKMMVEAYRKISSLVDYPLHLGVTEAGTKFQGTVKSAIGIGALLVDGIGDTLRVSLTENPVEEIKVAKEILKVLDLSDEGVEIISCPTCGRTEIDLIGLAKQVEEEFRTKKNKFKIAVMGCVVNGPGEAREADYGIAAGRGIG...
Cofactor: Binds 1 [4Fe-4S] cluster. Function: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Catalytic Activity: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + ...
Q7NS59
MTKTIMLANPRGFCAGVDRAIAIVERAIELYGAPIYVRHEVVHNRFVVDDLRGKGAVFIEELKDVPPGSTLIYSAHGVPLSVRAEAEALGLTVFDATCPLVTKVHVEVKRMNKAGMEIIMIGHAGHPEVEGTMGQVDAGIYLVQTVDDVATLRVVNEDQLSYVSQTTLSVDETRDIIAALKARFPNIHSPKKDDICYATQNRQDAVKLLADQCDIVVVVGSPNSSNSNRLREVAALKGVDAYMVDNASLLEPEWFAGKRRVGVTAGASAPEVLVQAVIDRIKAFDVTQVTELPGVEESTVFALPPALRPLF
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
B5E9S9
MQVILAKHAGFCFGVKRATQLAFQAANIGSETYTLGPIIHSPQVVQRLEEMGVIPVDNVSEVETGGTIIIRSHGVAAEELEAAVRANLEVVDATCPFVKKAQEHVATLSKEGYDIVVVGDAVHPEVQGIVSYAAGRVYVVSSHKDVERLPRMSKIGVVAQTTQSFEHLHEVVAACLARGGEARVYNTICDATAVRQEEAKKLAGAVDCMVVIGGFNSANTMRLAQICLELLPRTHHVETASQIDEQWFKGVKKVGVTAGASTPKWIIDEVIDRISAIDKDKIS
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
Q97I09
MRKVMLAEKAGFCFGVKRAVDMALLTQKEYNKKIYTLGELIHNNDVVDKLKDNNVYPIGIEDIDNLKENDVILIRSHGISEEIYKILLSKGLTVINATCPFVTKIQEKVKKYNELGYDIVIVGDKYHPEVIGINGWCDNKAIISKQGENLENITSESKVCIVSQTTEKLENWEKVLKEVKNRAIEVISFNTICNATSERQKIAKDLSNKVDFMVVIGGKQSSNTTKLYEICKSNCNETIHVENSGEIPENILKNKNCVIGVTAGASTPDWIIEEAISKMSENQISNETNNEMADAMKFIAENEGKIYVGASVTGEIIQVS...
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
Q187C6
MNIKIAKNAGFCFGVKRAMKMAWDEVEKNDSGIYALGPLIHNKQAVAKYEEKGLKTVNEIDTIPNHENMIIRSHGVPENIYKEAKDKKLKIVDTTCPFVKKIHTVVSEYHNKGYEIIVIGDMKHPEVIGINGWCENSAIIIKTLEQMENMEFDNSKRYCLVAQTTINPELYISIVNKLSDKLEEIVFNDTICSATKTRQESAKELAKEVDCMIVIGGKHSSNTQKLVKVCEDLVPTFAIETKDELDVNTLKKYKNLGITAGASTPNWIIEEVVTFLENL
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
P58675
MERNVILAKNAGFCFGVKRAVDEAIKYQKEFGKKIYTLGPLIHNNDVVNYLEDNNIFAIELSDADSLKKGDVVLIRSHGVKESVIKDLTDKGLIVKNATCPYVTNIQLKVKKCYEQGYKIIIVGDKNHPEVIGINGWCNDSAIITNGKTELENIPAKVCVVSQTTEKKETWNKVLNEIVRASKEIVAFNTICSATDVRQKSVQELSKEADLVFVIGGKNSSNTTKLYEICKKECPKSYHIENVKELDESLLEDESVKTIGITAGASTPDWIINEVISKIKEL
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
Q11YY5
MDVIIDKNSGYCFGVEFAIQMAEDEMATGEPLFCLGDIVHNSMEVERLAKKGLKIIDREELKKLSDCKVLIRAHGEPPETYQLALENNIELVDASCPVVLKLQNRVKASFDAIDSKDGQIVIYGQEGHAEVIGIAGQTGDKAIVITTEKDLDKIDFEKPVTLYSQTTKSTQGFYKMKDLIEARVAEAGKNVDENFEYNDSICRQVSNREPQLRKFSKEFDVVIFVSGKKSSNGKALYGVCKQENERSYFVENETEIEPSWIRATDNVGICGATSTPMWLMEKVQNYIQAHSWN
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
Q7ULU1
MTPMKIILAAPRGFCAGVNMAIDSLDLTLQKFGPPVYVYHEIVHNQFVVKTFREKGAVFVDTIDEVPEGGVLLFSAHGVSPEIRKAAQARKLHALDATCPLVTKVHLEAIKYAKAGYTIILIGHEGHDEVLGTMGEAPEAIVLVEDEADVDRLEFEPGTQLAYLTQTTLSVDDAGRVIRRLRERFPEIHSPPKDDICYATQNRQEAVKLLREDADVIVVLGSQNSSNSQRLKELAAEQGKRAMLVDGPQDLAVDQFSDDDRVLITAGASAPESVVQSTIDWLKENFDASVDTQVVREEDVQFPLPKPLRAFAAEQAAAK
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
Q5LNJ7
MTKSPLTLYLAAPRGFCAGVDRAIKIVEMAIEKWGAPVYVRHEIVHNKFVVDGLRAKGAVFVEELDECPDDRPVIFSAHGVPKAIPAEAERRQMVYVDATCPLVSKVHIEAERHAEHGLQIIMIGHRGHPETIGTMGQLPEGEVLLVETVADVARIAVRDPARLAFVTQTTLSVDDTRDIVAALQARFPQIVGPHKEDICYATTNRQEAVKAVAPKSDALLVVGAPNSSNSRRLVEVAAKAGCSYAQLVQRADDIDWRALDGIATIAVSAGASAPELLVNEVIDAFRARFDVTVEVVETAVEHVEFKVPRVLRQPA
Cofactor: Binds 1 [4Fe-4S] cluster per subunit. Function: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Cat...
Q97SR4
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV
Cofactor: Binds 2 magnesium ions per subunit. Function: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. Sequence Mass (Da): 28705 Sequence Length: 252 EC: 2.5.1.-
Q9X1B8
MRIPQHVAIIMDGNGRWAKKRGLPRIKGHQRGAEVLHNTVKWSLELGIKYLTAFSFSTENWKRPKEEVEFLMDLFVQMIDREMELLRRERVRVRILGRKEGLPEKVLKKWQEVEEKTKEFDRMTLIIAFNYGGRREILDAVEFILKDVSHGKKIELTEETFRQYLYLPDVPDPDLIIRTSGEMRLSNFLLWQSAYSELYFFKKLWPDFTKRDFLRAIESYSKRERRFGGLING
Cofactor: Binds 2 magnesium ions per subunit. Function: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. Sequence Mass (Da): 27859 Sequence Length: 233 EC: 2.5.1.-
Q5SH15
MVRRLLALSRPLYWLYEKRLLREVKRGPMPRHLGLILDGNRRYARALGLSPTKGHEFGVQKAYEVLEWCLEMGIKTVTVWVFSTDNFKRPPEEVETLMNLFLREAERMAEDHRILEHQVRVRFIGRREGFSPEVVRAIERLERRTEGHRGMFLNIAMGYGGREEIVDAVKRLLLEAEARGLSPKEVAEGLTPEDIARHLYTAGLPDPDFIIRTSGEIRLSGFLLWQSAYSEFYFADVLWPEFRKIDFLRALRSYQARERRFGR
Cofactor: Binds 2 magnesium ions per subunit. Function: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. Sequence Mass (Da): 30893 Sequence Length: 263 EC: 2.5.1.-
Q73K76
MSDELKHIAIVMDGNGRWAKKRGLPRSMGHKEGLNTVKRITKAVSDLGIPYITLYIFSTENWKRTEAEVGFLMGLIKQHLKAELKFYADNNIRIEHIGNLSGLPQDIQDEINSVRDKTSAYTGTAIVLGINYGAHDEILRAIKKLNSDELASINEESFSLKLDTGKIPPVDLLIRTGGEKRLSNFLLWQSAYAELYFTDTLWPDWTVENLYEAIEDYKKRNRRYGNA
Cofactor: Binds 2 magnesium ions per subunit. Function: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. Sequence Mass (Da): 25879 Sequence Length: 227 EC: 2.5.1.-
O83612
MQHVAIIMDGNGRWAERRGLRRSAGHRRGLQTAREIVAALCAIRVPFVTLYVFSTENWKRSAHEVHFLMNLIRWYLKKEMSFYVEHAIRVVHLGCAQTLPPDVRSQIEYVVERTRSHRGTTVALAINYGGKDEILRAVKKVLCSTSCPDGELLTEEAFGACLDAPQLPSVDFLIRTGGQQRMSNFLLWQSAYAEFYFTDILWPDFRVEDMLRALDEYRLRTRTFGGLE
Cofactor: Binds 2 magnesium ions per subunit. Function: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. Sequence Mass (Da): 26270 Sequence Length: 228 EC: 2.5.1.-
Q9X5F1
MIAPLANSAVKPHKSASFVPRHVAIIMDGNGRWASARHLPRIAGHKKGADAVKTTVRAAAEMGIEVLTLYAFSSENWRRPASEVADLMGLLRLCLRQEMHNIKERGICLKVIGDYTRLDQDLVALLNQAIEITANNTRLTLVFALNYGAQDELVHVTKRIAEKAKEGQLDPENIDVGTIESLLYTHDLPPLDLVIRTSGEKRLSNFLLWQAAYAELLFIDTLWPDFGSETLKAAVEEYARRERRYGGL
Cofactor: Binds 2 magnesium ions per subunit. Function: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. Sequence Mass (Da): 27715 Sequence Length: 248 EC: 2.5.1.-
Q863C4
MGIELLCLFFLFLGRNDHVQGGCAMGGAETCEDCLLIGPQCAWCSQENFTHLSGVGERCDTPANLLAKGCQLTFIENPVSQVEILTNKPLSIGRQKNSSNIVQISPQSLALKLRPGLEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSLLSKEMSKLTSNFRLGFGSFVEKPISPFMKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTILEYPTIGQLIDKLV...
Function: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6...
P26010
MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYS...
Function: Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally exp...
P26012
MCGSALAFFTAAFVCLQNDRRGPASFLWAAWVFSLVLGLGQGEDNRCASSNAASCARCLALGPECGWCVQEDFISGGSRSERCDIVSNLISKGCSVDSIEYPSVHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTM...
Function: Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin . It recognizes the sequence R-G-D in its ligands . Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a k...
Q27591
MTSLGGRAFLWIYLVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEYQVGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMILPQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELL...
Function: Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS in...
Q3ZBM4
MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNNNSDTCAEFRIKYVGAIEKLKLSEGKSLEGPLDLINYIDVAQQDGKLPFVPLEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGSGKSLLALKTTDANNQEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP
Function: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration...
O14713
MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNNNSDTCAEFRIKYVGAIEKLKLSEGKGLEGPLDLINYIDVAQQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP
Function: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration...
Q5R5S7
MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNSNSDTCAEFRIKYVGAIEKLKLSEGKDLEGPLDLINYIDVAQQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP
Function: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration...
P11584
MILERNRRCQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTEGCAWCMQPDFKGQSRCYQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCENCKAPYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDA...
Function: Integrin alpha-PS1/beta-PS is a receptor for laminin . Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m . Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle . Essential for migration of the primordial midgut cells and for maintainin...
Q96J02
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNLCLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPL...
Function: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation . Involved in the control of inflammator...
Q8C863
MSDSGPQLDSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPTSKLCFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTLQLVGDKEPTETMGDLSVCLDGLQVEAEVVTNGETSCSESTTQNDDGCRTRDDTRVSTNGSEDPEVAASGENKRANGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTNSDSDGSSTGSLPPTNTNVNTSTSEGATSGLIIPLTISGGSGPRPLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEP...
Function: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (By similarity). Involved in the cont...
J9VTS6
MSDEKNYGISLAAPARPDLGSRTASQLEKATASHVEFATPKDPGALHDATLMAGERTEKLTKFVVGLALFASVSGFCFGFDTGVISAALVSIKDDFGHILDDTEKEWISAATSCGALVGALSSGALADRVGRKWTLAVGDVWFTLGAIIICSSFSVVQMIVGRAVLGLGVGTAAAIAPLYIAEVAPTRFRGALVTVQSIAITGGQFFSYCIGIPLTGHNGWRIQFAIGIVPAVVQAAVVHFLPESPRYDLLRGQREAALATIHRSYKGMSEDYIAVKFAALEEVVGISADFNRGHTLGQKMRLVLTEGKYRKPAITALGI...
Function: Major transporter for myo-inositol . Plays a role in the traversal of the host blood-brain barrier . Catalytic Activity: H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60694 Sequence Length: 566 Subcellular Location: Cell membrane...
A0A1D8PH98
MGSSTNNTQSKATPSVLENEVNSSKSSVVSSTSSAKGLLRETTNHGTMETSSVQISESESRPSKMVLVLTLASSISGFMFGYDTGYISSALVQIGTDLSNKILTSGEKEFITSATSLGALLGAVVGGVLANLIGRRRVLLGSNIIFVVGTIIQLAARTVWTMIAGRFVLGWGVGIASLIAPLMISELAPAKYRGRLIVTNVIFITGGQLIAYFINWGLTRVSHGWRVSVGLCMVPPVLQFVLFWFLPDTPRFYVMNGNFEKARQVLRKVHVDPSDEFVNATIDEMIASDSTVPGNGPLQKAWKSIKIIHTTPGNFRALIL...
Function: Major transporter for myo-inositol. Catalytic Activity: H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 59703 Sequence Length: 554 Subcellular Location: Cell membrane
J9VHZ4
MSARPAQPNIYAPIRTSLSGYPSPTHSGSSTPASLEFSDGRLPENNVERDMSKVVERVALLGEADEGAVIVEGEDKVTKFVWMLVSAAAISGLLFGYDTAAISGMLVIIKDDLGTILSSWQKEVITSATTLGALLGGLAAGCVSDFTGRRLVIVFANVAFIGGSICQAACHTVAAMIAGRFIVGLGVGLASCIVPLYIGELAPTMIRGRLVTINCVAVTLGQVVAYAIGASFQNVHNGWRWIVGLGAMPSFVQLAAIGFLPESPRILLLRSDVAGARAITAKIYPLATIEQVDRKIEIMKAAVDQSIEYNANSTWFERLK...
Function: May function as a transporter or as a sensor for myo-inositol. Catalytic Activity: H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 60983 Sequence Length: 567 Subcellular Location: Cell membrane
Q10286
MSISSKDFQNVTSAGFADDTFAADTFAADKKSPFESSVFENKTQVLPVDSVSRLSNGARSRSNSNISLSEPHALNDTVEDQPVSKWVWVLAFAAGIGGLLFGYDTGVISGALVVIGTSLGGHELTNGGKEFITSATSLGALLGGIIAGALADFFGRKPVIAIASIIIIVGSIVQVTAHHLWHMIVGRFVIGWGVGIASLIIPLYLSEIAPSKIRGRLVIIYVLLITAGQVIAYGIDTAFEHVHNGWRWMVGLAMVPAAFQLFILIWLPESPRLLVKKERSQEAYNTLARIYPTAHPYEIKTKLYLIQEGVRDPFSGSRWQ...
Function: Transporter for myo-inositol. Catalytic Activity: H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 62758 Sequence Length: 575 Subcellular Location: Golgi apparatus membrane
Q43667
MAAFVESARAGAGADEVIQLVSDGVNEYSEKMMEGVVACPRILMPCKVNDDCLRGCKCLSNGYCG
Function: Inhibits trypsin. Sequence Mass (Da): 6877 Sequence Length: 65 Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Subcellular Location: Secreted
Q9US46
MLEVEVESDNKHLVADELIALQSIYPEIHLDGNNYGRLNIPVNTESDYFLSFKSPDESTLTDTIVVRHFPDLVMEFFLPEAYPFNSPPTFFLKSSWLPLKQKRVLTSSLIKLWNEIHDCVLFDAIEHVRSIATIAFHLPTEMVFPGGFDDLKKEILAFDKNAKLLEFQIRKFQCNVCFDEFNGTDCFQLTRCGHVSCQSCLRDYYTMCIQEGMFSQIKCIDLDCGKDAPVLTLKELESIVGVQLTNRYKELEEKRRYENDSNIIFCPRSFCQGPSKRDPGQKLAICQKCDFAFCSFCQATWHGDLSPCKLEGDSKKLVEM...
Catalytic Activity: [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine. Sequence Mass (Da): 50297 Sequence Length: 435 Domain: Members of the RBR family are atypical E3 ligases. They inter...
Q04638
MALTQFENDLEILRDMYPELEMKSVKVEEEGEFPQRINGKLLFKISLLADVNIEFGEQHMLLSNLSNECVEFTIYSCHYPDIRRCVVMDIKSLWISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPNGIRKCLTQDQYDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCH...
Function: Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA. Catalytic Activity: [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor prot...
Q47316
MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLRPWQGEYLFQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTF...
Function: Catalyzes the attachment of a first N-acetyl-N-hydroxylysine to a carboxylic group of citric acid to yield N-citryl-N-acetyl-N-hydroxylysine. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced under iron-stressed condit...
Q76BS7
MHRNNERINLEKSNDWANTNEPSIACFLNSLARESQSVQLLWGEDGKRVYRLPLANSDSINIPLSYFSSLGSHEYCLPALLHTQDSIKTLSVEQLIEHIVNEPALVGIVSEAKKAIFTKRVLESHRNTEQAIEHSPYQEQLFTEQLDFKTAEQGLLIGHSFHPAPKSREQFSLSDAKLYSPELGGQFKLFWLSVEQSLLTSGSSADIHFNQRFEALVAHDPKLVEALQNAQQQGHELLPVHPWQWHVMVENPSIKGYIATKQIQNLGQLGATWYPTSSTRSLYAPGLPYMLKFSLSVKLTNSIRNLSLKECDSWNDLNDL...
Function: Catalyzes the attachment of a first N-acetyl-N-hydroxylysine to a carboxylic group of citric acid to yield N-citryl-N-acetyl-N-hydroxylysine. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced under iron-stressed condit...
Q47317
MSGPNIVHSGYGLRCEKLDKPLNLGWGLDNSAVLHWPGELPTGWLCDALDQIFIAAPQLSAVVLPWSEWCEEPQALTLFGQVQSDIIHRSAFWQLPLWLSSPANRASGEMVFDAEREIYFPQRPPRPQGEVYRRYDPRIRRMLSFRIADPVSDAERFTRWMNDPRVEYFWEQSGSLEVQIAYLERQLTSKHAFPLIGCFDDRPVSNIEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGVTHYLLLNEPRTQRTVLEPRTDNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL
Function: Catalyzes the transfer of acetyl from acetyl-CoA to the N-hydroxylysine. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced under iron-stressed conditions. Catalytic Activity: acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + ...
Q47318
MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQEKIATDFIADFGEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVIL...
Function: Catalyzes the attachment of the second N-acetyl-N-hydroxylysine to the carboxylic group of N-citryl-N-acetyl-N-hydroxylysine to yield aerobactin. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced under iron-stressed co...
Q76BS5
MVMDQLALHRYWAVANQKMVGKILSEFAYEQAFQFEPTAQGYQLNLENGTRYCFAGEENIWGQVMIDPTSITRHAEIEADEPISAALLMRDLQPLLKMPDDAFAEHLEDLNATLLGDCKLMQRNEAITARDLAMLPCEQQQTYFDGHPKFVFNKGRRGWGSDDLKRYAPEAERVSNWVGSRFITRFCSSPPTMKSHGKPCCKAPSRPMKSSRWTVCWLPISLDSTIIVMFRFILWQWSNKLALLFVREIATKQLVYLGEFGDHFLPQLSLRTLSNVTRPAGYDIKLPLTVMNTSCYRGIPGRYILAGPTASDWIDQVFKS...
Function: Catalyzes the attachment of the second N-acetyl-N-hydroxylysine to the carboxylic group of N-citryl-N-acetyl-N-hydroxylysine to yield aerobactin. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced under iron-stressed co...
P11295
MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRES...
Function: Flavoprotein monooxygenase required for N-hydroxylation of lysine. Involved in the biosynthesis of the siderophore aerobactin which is a chelator that mediates the high-affinity iron transport systems induced by the organism under iron-stressed conditions. Catalytic Activity: L-lysine + NADPH + O2 = H2O + N(6...
Q27546
MPKKIILDCDPGLDDAVAILLAHGNPEIELLAITTVVGNQTLAKVTRNAQLVADIAGITGVPIAAGCDKPLVRKIMTAGHIHGESGMGTVAYPAEFKNKVDERHAVNLIIDLVMSHEPKTITLVPTGGLTNIAMAARLEPRIVDRVKEVVLMGGGYHEGNATSVAEFNIIIDPEAAHIVFNESWQVTMVGLDLTHQALATPPILQRVKEVDTNPARFMLEIMDYYTKIYQSNRYMAAAAVHDPCAVAYVIDPSVMTTERVPVDIELTGKLTLGMTVADFRNPRPEHCHTQVAVKLDFEKFWGLVLDALERIGDPQ
Function: Catalyzes the hydrolysis of the N-glycosidic bond of commonly occurring purine and pyrimidine nucleosides into ribose and the base, but has a preference for inosine and uridine as substrates. Is not active on thymidine and 2'-deoxynucleosides. Functions in purine salvage from the blood of the host, a fundamen...
P83851
MPRKIILDCDPGIDDAVAIFLAHGNPEIELLAITTVVGNQSLEKVTQNARLVADVAGIVGVPVAAGCTKPLVRGVRNASHIHGETGMGNVSYPPEFKTKLDGRHAVQLIIDLIMSHEPKTITLVPTGGLTNIAMAVRLEPRIVDRVKEVVLMGGGYHTGNASPVAEFNVFIDPEAAHIVFNESWNVTMVGLDLTHQALATPAVQKRVREVGTKPAAFMLQILDFYTKVYEKEHDTYGKVHDPCAVAYVIDPTVMTTERVPVDIELNGALTTGMTVVDFRYPRPKNCRTQVAVKLDFDKFWCLVIDALERIGDPQ
Function: Catalyzes the hydrolysis of the N-glycosidic bond of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates. Likely functions in purine salvage from the host, a fundamental pathway since protozoan parasite...
P14542
MMISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNMHHIEVIFGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTDGHLISLQYSDSAFLGQELVGQVYYRDES...
Function: Receptor for cloacin DF13/aerobactin. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 81014 Sequence Length: 732 Subcellular Location: Cell outer membrane
A0A1W7HCY1
MSGHSFFEHLFEHSQHVTPYLHGAIKPRPERCAEHGFIHIEHASSDHIRALYESLKLAHPEAGAAYWLTRTWTLLCWQPLYVAFIAIYSCQGLPKLSSMGQHVQPRFVSGYQFDDDEYRQGSEQELIAHAGKELCALFDYFRQEMSLWTRIRPGFTQHLFADGVFGCLVKLSQFYPTLSGDYFLEQARLWLAACQLPEKLIQSLRYDETSRQLSLVRTSCCLVYKCQGRELCRDCPRHPDNKRE
Cofactor: Binds 1 [2Fe-2S] cluster. Function: Ferric-siderophore reductase involved in iron removal from the siderophores after their transport into the cell (Probable). Acts as a major ferric-aerobactin reductase catalyzing the reduction of Fe(3+)-aerobactin, a citrate-hydroxamate siderophore produced by other bacteri...
Q7NN81
MMRFLILATNNQGKLQELRRLLAGTGWVVQAAPPDFAVEETGTTFAENARLKALAAAERTGEWSVGDDSGLAVDALGGAPGVYSARYGRNDGERISRLLAALAGQADRGARFICAIALAEPGRVLKEVEAECRGVILHAPRGNGGFGYDPIFLVPELDKTFAELDIVEKERHSHRGRAVRKLLSGCSRGTFIVDH
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
Q7VLS3
MNRTKIVLATSNKGKVKEMADVLSAFGFEVIAQSEFGLVSPPETGLTFVENALLKARYASKMTGLPAIADDSGLAVDALAGAPGLYSARYAGIEDDDTANRRKLLAEMQNVPDGQRAAKFVSCIVMLKHETDPTPKIAFGECFGEILREERGQNGFGYDALFFYPAKQCTFAELDSTEKKQISHRALALVALQKQL
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
P44598
MKQKIVLATGNKGKVKEMADVLSDFGFEVIAQTDLGIESPEETGLTFVENALLKARYASEKSGLPAIADDSGLVVSALNGAPGLYSARYAGEEGNDAKNREKLLAELAHIAQEQRQAKFVSCIVFLQHPTDPSPIIAEGECCGVIGFEEKGENGFGYDSLFFSPEQGCTFAELETAEKKKISHRAKALSVLKSKL
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
Q7VF43
MVIVLASANQHKICEFQAMLKNVKEKVKVYAYGELLETFEIAENGNSFKENATLKVKAIYQALYTLSQSTMQENIRNLFAQPLAIIAEDSGLCVPVLNGEPGIYSARYAHHKQFASMQYKNTDEANLYCLLNALTHCAPTPAFFVAHIALIFIKPYFCTYTLPPLEQCVIEHFEGILNGEVINEMRGNEGFGYDPLFIPAEHNPQSLTLAEFDMSAKNTISHRKKALSQCINRLFDKS
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
B4U8R9
MKLMICTSNKKKFEEISSILESLKKDENLDLEFVKPPKEIEVEEYANTFLSNAYLKAKAYYNAFGIPALADDSGLVVEAFSDNLERPGVYSARFYKDSFGSHVLKEEDFKLSKDELNNLKVLRLLEKEENRKAKFVSVVAIVLSNNYGIFGEGELKGHIAKEPFGNFGFGYDPIFIPEGYNTTLANIENKDKISHRRQALEAVFFMLKKML
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
A2BJY7
MEARVILIATTNKHKIEEINEVLQSCGYRVEPAAASKLEVQSNRLEDVAAYAAIQAYLALQRPVIVEDAGLFVEALGGFPGPYSSYVFKTIGIRGLLKLLEDVENRRAYFKSVIALAHSGGVEVFTGTVHGVIAEKPRGDRGFGYDPVFIPEGSSKTFAEMETQEKNKFSHRGKAARELCRWLRQYGPPR
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
A8A8W1
MVSKKVYFLTSNPHKAKEVSDVLSQFSIEVVPLKGEKLEIQADSVEEVARFAAEEAKKRFKERPLLLEDSGLFVDALKGFPGPYSNYVYRTLGLEGLLKLMEGVEDRRARFVCAAALVKEDDKIVIEVGEVEGEIAYEPRGDKGFGFDPIFVPLGYEKTFAELGEEVKKRISHRARAFMKIAKHLSGE
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
B1L6T7
MIFASSNRHKYEEFRRMLSDLIDLKFLEVDYLEPQGEDTREIVVTSAKWLSNYIREPFFIEDSGLFIEALNGFPGPYSSYVFKKIGNEGVLKLMNGVENRRAFFISVIALSYGRGIEVFEGRVQGTIAREVRGGGWGFDPIFIPNGSNKTYGELGDEKDRFSHRGASCRKLREFLMRFGSDRLP
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
Q5FLV7
MSQKILFATGNKGKARELKEAFKTAGVDVEIITNSDLDNPPHPIESGRTFEANAKIKAHELADYSKLPTIADDSGLMVDALNGEPGVRSARYAGEAHNDAKNNAKLLANLGGIPDEKRTAKFWTTIVVSMPGEFEKDLVVSGTCSGRILAAPRGDDGFGYDPLFFVPKKDKTFAQMTTDEKNEISHRGNVVRELLKVLPALA
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
Q9CG29
MEKTLIIATRNSGKTKEFKKLFADFGYEIKDLTDYPELSEIEETGTTFEENARLKAEQIAEITGQVVIGDDSGLCVDVLGGLPGIWSHRFSAPDPTDEKNIAKLLHELAPTAITPERRSAHFHTTLVAAKPGRESLVVEADWDGYIALAPKGENGFGYDPIFMVDAFRTAAELSEKEKNQVSHRGQALRKLMAELPEWLYK
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
Q88V20
MTKPQTLIIATNNANKAREFSAMLAPYDITIKTLADFPNIPEIKENGITFEENATKKATVVVEATGLPAIADDSGLMVKALHGDPGVFSARYAGDHDDAANNAKLLANLGGVPEAERTATFHTTLVALKPSGEKLVVNGELAGRILIAPRGDNGFGYDPLFWSSKFQKSLAELTPAQKNQISHRGAALRQLMTKFDEWWAKA
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as ...
E9FR69
MENYVPFLVSHWRTVGLISVSIAAGVALGQLNQTHERAANKSQRVHTNSSIKAKQVKRESAIEQINEIEDDDEQSLEDQDVLPILFQYEKPSEADSIRRSEEFYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAEEEINYKQRMGDVWVQDLQPVGTTWVKEYLTEAPWLILIFKQVHGFKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNCGPSIRVLLGRPVNEKLLLLLPVGYPKVGATVPDFKRKPLHDIMVHYQ
Function: Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine . Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity). PTM: May be cleaved at Gln-55 . The cleaved form retains catalytic activity . L...
E1JIB2
MDVDELISSSKLLKHWPSLFITLALIWIVKRLFFKGNRVLKTYNLDEQVEEEVEHFADLGDELQPALEDKPHVPFVPGQNLNPNGAKRLYELMRGRRSIRSFNSHPKPDLSVIEDCIRAAGTAPSGAHTEPWTYCVVQEPELKRSIREIVEQEELVNYSQRMHPQWVTDLRPLQTNHVKEYLTEAPYLILIFKQTYGLSENGKRMRRHYYNEISTSIAAGILLCALQAAGLASLVTTPLNCGPALRNLLGRPVNEKLLILLPVGYPKDGCTVPDLARKNLSNIMVTF
Function: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine . Activity towards 3-fluoro-L-tyrosine is weak . Important for male and female fertility . May be involved in maintaining the viability of sperm, both during development i...
F4KU78
MKQKPAFIPYAGAQFEPEEMLSKSAEYYQFMDHRRTVREFSNRAIPLEVIENIVMTASTAPSGAHKQPWTFVVVSDPQIKAKIRQAAEKEEFESYNGRMSNEWLEDLQPFGTDWHKPFLEIAPYLIVVFRKAYDVLPDGTQRKNYYVQESVGIACGFLLAAIHQAGLVALTHTPSPMNFLQKILQRPENERPFLLVPVGYPAEGAMVPDLQRKDKAAVMVVY
Function: Catalyzes the dehalogenation of halotyrosines such as 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine . Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity). Activity towards 3-iodo-L-tyrosine is much stronger than ...
T2MBC4
MFDNLSGVSYGLLAGILAMLIHLVYQKITELKRRKDELKERESHPTDDLFPKEDFIPYHPSRYSEEEMIKRSNDFYLSMNARRSVRFFSNEDVPDEVIDNIIRTAGTSPSGAHTEPWTFVVIKNKLLKAKVREIIEEEEELNYKQRMGQKWVDDLKPLKTNWIKEYLTEAPYLILVFKQTYGITEDGQKKTHYYNEISASISCGFLLAAIQNAGLVALTSTPLNAGSKLRNLVGRGPNEKIVILLPVGYPSKNCQVPNLKRKPLNEIMIKFD
Function: Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine . Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity). Catalytic Activity: 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine +...
A7S5D9
MEVFKALFKSKEAYTVDVDPMKDSDEHDLPRDPLSIRVTGEEEVNHIPYPYFDEIPTEEEMKKKSAEFYKSMKKRRTVRKISSEPVPLEVIENIVRVAGTSPSGAHTEPWTYVVIRDPDLKKQIKEVVEEEEQLNYARRMGEKWVQDLSILKTTWSKPYIETAPYLILIFKQVYGIKPDGDKKVHYYNEISVCISCGLLLAAIQNAGLVTVTSTPMNAGPRLRVLLNRPQNEKLIMLLPVGYPAKDAEVPNLTRKPLEEIMVLK
Function: Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine . Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity). Catalytic Activity: 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine +...
B9K712
MKMLYDLAKKRKTVRRFKKEKPPLEDLIYSLKVANEAPSGMNAQPWRFLIVEDEKLKGQIRRVCERSEKTFYENVRGRLKEWLDEKRFTWRKPFLKEAPYLLLVFSEKSAPYSRESVWLAVGYLLLALEEKGLGSVPYTPPDFREVEKLVNTPSELRLEVILPVGYPDDPKPKYPRNEVIVRYNTF
Function: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine . Activity towards 2-iodophenol is weak . Catalytic Activity: 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH Sequence Mass (Da): 22028 Sequence...
Q753H5
MSEERGMKEQTISEMAQEMAHTTSEGLKKRIRKLYTFDELPAWQKDNELILSGYVRETNSVKECLRAMTYFNNESINIYTHLIPGVAYLVLFLIFADLVLAQLLPGLDAGEHRMLRFYLLGAFTCLACSSCFHCLKQHSEPHSRLWSKVDYLGILAQITCSTISLLYYGYHSYPSHFVFFSTLTVALCSACAVLVLNDSFNTVAFRPLRAFLFMAFGLSGVIPVLAGSYQFGFAEWAARIQLKYVLYEAVFYITGALVYGFRIPERFAPGKFDMVGHSHQIFHLLVVLGTLCHFRAVTGSYIFICTGKHYSSLLMFI
Function: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 35981 Sequence Length: 317 Subcellular Location: Endoplasmic reticulum membrane
Q03419
MSITTTRRRNQDSVCCKATRASIKVEAVSGQTVFEKQKLLHNFDELPEWQKDNDKILTGYVRETLSWKKCLYSLFYWNNETVNIYTHLVPAIVYFVFAITLTNYFLIPVFPSTSWSDYTVINIFLMGAFSCLMCSSCFHCMKQHSEKQSNFWSKLDYLGIISLISCSMIPIIYFGYFDHISYFSLFTIVTLVLATFCTVCVLHDKFNTSTFRPFRAMFFILFGFSGLLPLTTGFFKFGIQGVLNRIKVSFVFWEALFYISGAVIYGFRIPETLAPGKFDFFGSSHQIFHIMVVLGSVCHLKAIIDSYKLMHSHIHP
Function: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 36492 Sequence Length: 316 Subcellular Location: Endoplasmic reticulum membrane
Q12442
MSTLLERTKSVQELKKRAAGKTSANPAEVAKAKKVLRRLYSWDEIPEWQRDNDFILHGYVKETSSFIETFKSLFYLHNESVNIYSHLIPALGFFTVLLLDKSTIKVFATTTWLDHMVIDLFYSGAFACLILSSSFHCLKSHSLRIATLGNKLDYLGICILIVTSMVSILYYGYFEKFSLFCLFALITVSFGIACSIVSLKDKFRKREWRPYRAGLFVCFGLSSIIPIFSGLYCYSFSEIWTQIQLFWVLLGGVLYIIGAVLYGMRFPEKICPGKFDIWGHSHQLFHFLVVIAALCHLRGLLNSYELVHIKMENGIVS
Function: Probable receptor, which is involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 36279 Sequence Length: 317 Subcellular Location: Membrane
Q75F81
MSHPNTHMPRTHAVHGRAAPQRRGCRTSVEKTDQSGHSRSSLAESAMEQAQLRSRGEAGGGRSVLCASGEPGSAHKWAGAVTCSGAEEQPLHWAESRARGLARHLHYWELPYAWRENRYIIYGHRFYHSHRKSLLSVLNAYGWHNETINIWSHLVGAAVLAYLLCWGWPRSDVYRAAQVPRLAKWAIGAFLACGVKCMASSVAWHTFNGTCHLKLRSRFVCVDYTGITLLVTASVVTTVAVTLYGLSRPLMYAYMVASIGLGTAAGVMNWSPHFDRPEARPLRIAVYVGLAALGLVSFVHVWMQVRWASAHLMAPLVYKS...
Function: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 47153 Sequence Length: 419 Subcellular Location: Endoplasmic reticulum membrane
Q07959
MMDSSSKSLTQYIPSPMGSLSRLKQKGVDNFQKVKKSGKSIYNYNYSKFVPHPFSTIDESVKHSESGRYDDLEIIRPTKEKEVTSSVYKRNSGKSLNTESQFSLGDSDAATLVNSVATFKLNNASTSTSLVSSSSTVCSQAKSSLRSPTSRLNDTKIKEENNYISSVKDYCGPMRKSMVKTEILIEEPLNPTTDIKSFINSYNHGKAYSLGETQHLHYYQLPFPWRENRYIIHGYRFYNTHSKSLLSIFNWYGWHNETSNIWSHLLGAIYIIYLAIYDFPQSEVWRNSQVPPQARWIVFMFLAAALKCMLSSVFWHTFNG...
Function: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 62571 Sequence Length: 543 Subcellular Location: Endoplasmic reticulum membrane
Q99393
MVSLTTIEQSPVKCETTTEKESNDTRGTDSNENAETKETKKGFPFHDLAKLQKQYKNKSSRNESLVALIYLLGSMLSFCLLIFFTDFYLIPLFPTTTTMTDYIVFNFYLLNVFVFCMVHFIYHFVKNISLQQHLEHWQKFSYLSNINLLISSQITILYYLFYDYVFFFKIFTLLMNFIGLVAYFFILTDKLISSKRFNKTVFFISVSVVCCSLPLLTAIITFDGLENLKERIKVNAITWELVALVAASIIYVTRFPESLFRRNKKEEGWNHSEYLFHLLISGTAFYHFFILIQSYILMHSSLNQPELINFKS
Function: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 36608 Sequence Length: 312 Subcellular Location: Endoplasmic reticulum membrane
Q8IYV9
MGPHFTLLCAALAGCLLPAEGCVICDPSVVLALKSLEKDYLPGHLDAKHHKAMMERVENAVKDFQELSLNEDAYMGVVDEATLQKGSWSLLKDLKRITDSDVKGDLFVKELFWMLHLQKETFATYVARFQKEAYCPNKCGVMLQTLIWCKNCKKEVHACRKSYDCGERNVEVPQMEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLPKMIKEEKPSPNIVTPGEATTESSISLQPLQPEKMLASRLLGLLICGSLALITGLTFAIFRRRKVID...
Function: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interact...
Q9D9J7
MGPHFTLLLAALANCLCPGRPCIKCDQFVTDALKTFENTYLNDHLPHDIHKNVMRMVNHEVSSFGVVTSAEDSYLGAVDENTLEQATWSFLKDLKRITDSDLKGELFIKELLWMLRHQKDIFNNLARQFQKEVLCPNKCGVMSQTLIWCLKCEKQLHICRKSLDCGERHIEVHRSEDLVLDCLLSWHRASKGLTDYSFYRVWENSSETLIAKGKEPYLTKSMVGPEDAGNYRCVLDTINQGHATVIRYDVTVLPPKHSEENQPPNIITQEEHETPVHVTPQTPPGQEPESELYPELHPELYPELIPTVAQNPEKKMKTRL...
Function: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg . The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion . The ligand-receptor intera...
Q8WYK2
MMPGQIPDPSVTTGSLPGLGPLTGLPSSALTVEELKYADIRNLGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK
Function: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by r...
P97875
MMPGQIPDPSVTAGSLPGLGPLTGLPSSALTTEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKLERQQLILMLNRHRPTCIVRTDSVRTPESEGNPLLEQLDKK
Function: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by ...
P9WJW8
MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAGYSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTVARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPALGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQLTLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEHRAAFPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLHAGLMMLPVPAGFGVASLLAGRA...
Function: Involved in resistance to ethambutol and isoniazid. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 53479 Sequence Length: 508 Subcellular Location: Cell inner membrane
Q9PTT2
MKGLVIFFCLFYGCHVAGATGKTIMLFPQKTDTDYVTLKPTERVLNQITVCLKSYTELIKEHSLFSLAMQGSGKDNTLLIYPYPPNNISISIHNEDIYFKVDPEVLQWKRTCVTWDSKTGLLQLWINGKLYPRRITKSRSPIGPQISVILGQEQDSYGGSFDINQAFVGEMSDVNVWDYVLPPENIKAYFSDDYTLDGNFYSWDGGNYTINGLIVVLRNQFIPKL
Cofactor: Binds 2 calcium ions per subunit. Function: Calcium-dependent beta-galactose specific lectin. PTM: Glycosylated. Sequence Mass (Da): 25618 Sequence Length: 225 Subcellular Location: Secreted
P40358
MILISGYCLLVYSVILPVLISASKLCDLAELQRLNKNLKVDTESLPKYQWIAGQLEQNCMTADPASENMSDVIQLANQIYYKIGLIQLSNDQHLRAINTFEKIVFNETYKGSFGKLAEKRLQELYVDFGMWDKVHQKDDQYAKYLSLNETIRNKISSKDVSVEEDISELLRITPYDVNVLSTHIDVLFHKLAEEIDVSLAAAIILDYETILDKHLASLSIDTRLSIHYVISVLQTFVLNSDASFNIRKCLSIDMDYDKCKKLSLTISKLNKVNPSKRQILDPATYAFENKKFRSWDRIIEFYLKDKKPFITPMKILNKDT...
Function: Acts as a DnaJ-like chaperone required for nuclear membrane fusion during mating. Location Topology: Single-pass type IV membrane protein Sequence Mass (Da): 75144 Sequence Length: 645 Subcellular Location: Endoplasmic reticulum membrane
P36035
MSSSITDEKISGEQQQPAGRKLYYNTSTFAEPPLVDGEGNPINYEPEVYNPDHEKLYHNPSLPAQSIQDTRDDELLERVYSQDQGVEYEEDEEDKPNLSAASIKSYALTRFTSLLHIHEFSWENVNPIPELRKMTWQNWNYFFMGYFAWLSAAWAFFCVSVSVAPLAELYDRPTKDITWGLGLVLFVRSAGAVIFGLWTDKSSRKWPYITCLFLFVIAQLCTPWCDTYEKFLGVRWITGIAMGGIYGCASATAIEDAPVKARSFLSGLFFSAYAMGFIFAIIFYRAFGYFRDDGWKILFWFSIFLPILLIFWRLLWPETK...
Function: Essential to lactate transport. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 69376 Sequence Length: 616 Subcellular Location: Membrane
Q9GYI4
MSLGRDRYSLPRTYKRVSHAKDKARPELRKFGWETLGYSESFNLPPFRDSIQRVDGNNLTVEEFRRDFERPRIPVIITGLTDNWAAKDKWTVERLSKKYRNQNFKCGEDDNGNSVRMKMKYYHDYMLNNKDDSPLYIFDSSFAERRKTKKLSEDYSVPKFFEDDLFHYADDKKRPPHRWFVMGPARSGTAIHIDPLGTSAWNSLLQGHKRWVLIPPIAPRDLVKPMAHEKGKHPDEGITWFQTVYKRVRSPSWPKEYAPIECRQGPGETMFVPSGWWHVVINEEYTIAVTHNYCSVENLHLVWPKTVKGRPKLSKHWVKR...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Sequence Mass (Da): 46618 Sequence Length: 400 Subcellular Location: Nucleus EC: 1.14.11.-
Q6PFM0
MNHKSKKRIKEAKRSARPELKDSSDWTKHEYCKSFDLSHRSVKDNVERADVQRLSPEEFIQRFEKPYKPVVLLNVEDSWPAREKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYVEYLESTHDDSPLYIFDSSFGEHAKRRKLLEDYQVPLFFRDDLFQFAGEKRRPPYRWFVMGPARSGTGIHIDPLGTSAWNALVQGHKRWCLFPTHTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQQSTWPDEFRPLEILQRPGETVFVPGGWWHVVLNLDTTIAVTQNFASTTNFPIVWHKTVRGRPKLSRKWYRILKQER...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylat...
Q6NYC1
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEH...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase . Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxyla...
Q6Q4H1
MDKRTDDAVRETKLKARPELKGDEGWTRLGYANNFDLSYQHIKDTLPRIHCKSISHDEFIARYEKPRIPVILTGCTDSWLANQKWKLSSLAKKYRNQKFKVGEDNDGFSVKMKMKYYIEYLKHQKDDSPLYIFDGSYGEHPKKRKLLDDYHPPSFFQDDLFKYAGEKRRPPYRWIVIGPARSGTGIHIDPLGTSAWNALISGHKRWMMFPTETPKHLLEVSKQDGQHQSGEGIQWFVKVYPKVKSPTWPKEYAPLEIIQHPGETVFVPGGWWHVVLNLDQTVAVTQNFSSPTNFHVVWHKTVRGRPKLSQKWLRALKIYR...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Sequence Mass (Da): 44240 Sequence Length: 385 Subcellular Location: Nucleus EC: 1.14.11.-
Q9ERI5
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLNPAAVPDNVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEH...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylat...
Q6AYK2
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESYPLSPAAVPDNVERADALQLSVKEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEH...
Cofactor: Binds 1 Fe(2+) ion per subunit. Function: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylat...
P0C870
MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWFHHVQQSQGCIAVNFWYDMEYDLKYSYFQLLDSLTKASGLD
Function: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase . Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation . Preferential...
P0C872
MAEAALEAVRRALQEFPAAARDLNVPRVVPYLDEPPSPLCFYRDWVCPNRPCIIRNALQHWPALQKWSLSYLRATVGSTEVSVAVTPDGYADAVRGDRFVMPAERRLPISHVLDVLEGRAQHPGVLYVQKQCSNLPTELPQLLSDIESHVPWASESLGKMPDAVNFWLGDASAVTSLHKDHYENLYCVVSGEKHFLLHPPSDRPFIPYNLYTPATYQLTEEGTFRVVDEEAMEKVPWIPLDPLAPDLTQYPSYSQAQALHCTVRAGEMLYLPALWFHHVQQSHGCIAVNFWYDMEYDLKYSYFQLMDTLTRATGLD
Function: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (By similarity). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongatio...
Q96S16
MAPASRLLALWALAAVALPGSGAEGDGGWRPGGPGAVAEEERCTVERRADLTYAEFVQQYAFVRPVILQGLTDNSRFRALCSRDRLLASFGDRVVRLSTANTYSYHKVDLPFQEYVEQLLHPQDPTSLGNDTLYFFGDNNFTEWASLFRHYSPPPFGLLGTAPAYSFGIAGAGSGVPFHWHGPGYSEVIYGRKRWFLYPPEKTPEFHPNKTTLAWLRDTYPALPPSARPLECTIRAGEVLYFPDRWWHATLNLDTSVFISTFLG
Function: Functions as a positive regulator of TNF-induced NF-kappa-B signaling . Regulates angiogenesis and cellular metabolism through interaction with PKM . PTM: N-glycosylated. Sequence Mass (Da): 29509 Sequence Length: 264 Subcellular Location: Endoplasmic reticulum lumen
A0A061FBW2
MEVMQVLHMNKGNGETSYAKNSTVQSKIISVGKPIIEEAVHEISCNNLLESMGIADLGCSSGPNTLSVISEIMDMVQTTSRRLGRPVPEFRVYLNDLYSNDFNYIFMSLPAFYHRLKEEKGIGCGSCYISGVAGSFYGRLFPSKSLHFVHSSSSLHWLSQVPPGLESKALAPLNKGKVYISKSSPQSVLNAYSLQFQNDFSMFIESRSQELVPGGRMVLSFMGRRSTDPTTEESCHHWELLAQAIMSLVREGLIEEAKVDSFNAPYYAPCAEEIKVEIQKVGSFVIDRLEGFEIDWDGGAVSDVQTAQGKLLIGQRVAKT...
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the methylation of jasmonate into methyljasmonate, a plant volatile that acts as an important cellular regulator mediating diverse developmental processes and defense responses. Catalytic Activity: jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate +...
Q9AR07
MEVMRVLHMNKGNGETSYAKNSTAQSNIISLGRRVMDEALKKLMMSNSEISSIGIADLGCSSGPNSLLSISNIVDTIHNLCPDLDRPVPELRVSLNDLPSNDFNYICASLPEFYDRVNNNKEGLGFGRGGGESCFVSAVPGSFYGRLFPRRSLHFVHSSSSLHWLSQVPCREAEKEDRTITADLENMGKIYISKTSPKSAHKAYALQFQTDFWVFLRSRSEELVPGGRMVLSFLGRRSLDPTTEESCYQWELLAQALMSMAKEGIIEEEKIDAFNAPYYAASSEELKMVIEKEGSFSIDRLEISPIDWEGGSISEESYDL...
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Catalyzes the methylation of jasmonate into methyljasmonate, a plant volatile that acts as an important cellular regulator mediating diverse developmental processes and defense responses. Catalytic Activity: jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate +...
Q8N9B5
MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGPRRSSAWAEGGSPRSTRSLLGDPRLRSPGSKGAESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY...
Function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions . In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP...
Q9HCI6
MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLEYIDLVCGDDENPSAYYSDILFPKMPKRQGDFLHFLNVKKVKTDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGSKAEKHVHVSKEWIAYLVTPNGSNKTTRQASLRKKIREHDVSKAHGKIQDLLKESTNDSICNLVHKQNNKNIDATVKVFNTVYSLVKHNRPLSDIEGARELQEKNGEVNCLNTRYSATRIAEHIAKEMKMKIFKNIIEENAKICIIIDE...
Function: E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins . Sequence Mass (Da): 89673 Sequence Length: 787 Domain: Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UB...
Q9QR69
MKTLIFFWNLWLWALLVCFWCITLVCVTTNSIDTMASLLVMCILFVSAINKYTQAISSNNPKWPSSWHLGIIACIVLKLWNLSTTNSVTYACLITTAILSLVTAFLTLIKHCTACKLQLEHGILFTSTFAVLMTNMLVHMSNTWQSSWIFFPISFTLSLPFLYAFATVKTGNIKLVSSVSFICAGLVMGYPVSCCKTHTCTATAAGLSLSSIYLGFTGIISTLHKSWAPPKRGILTFLLLQGGVLTTQTLTTELLAITSTTGNIKGHEILLLVCLIFLWCLYVWQSFNKASLVTGMLHLIAAWSHTGGCVQLVMLLPSGL...
Function: Plays a crucial role for reactivation of the virus from latency, early viral gene expression and virus production. Modulates host signaling pathways including activation of MAP kinases c-JUN-N-terminal kinase (JNK), ERK2, and NF-kappa-B resulting in the activation of AP-1 and NFAT-dependent gene expression in...
P04264
MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQ...
Function: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. PTM: Undergoes deimination of some arginine residues (citrullination). Sequence Mass ...
P13647
MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGYGSRSLYNLGGSKRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGAGGGFGLGGGAGFGGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSD...
Function: Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokin...
Q922U2
MSRQSSVSFRSGGSRSFSAASAITPSVSRTSFSSVSRSGGGGGGRISLGGACGAGGYGSRSLYNVGGSKRISYSSGGGSFRNQFGAGGFGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVLGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEARVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLS...
Function: Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress . Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage ...
P35028
MKIGIVTGIPGVGKSTVLAKVKEILDNQGINNKIINYGDFMLATALKLGYAKDRDEMRKLSVEKQKKLQIDAAKGIAEEARAGGEGYLFIDTHAVIRTPSGYLPGLPSYVITEINPSVIFLLEADPKIILSRQKRDTTRNRNDYSDESVILETINFARYAATASAVLAGSTVKVIVNVEGDPSIAANEIIRSMK
Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 21110 Sequence Length: 194 Subcellular Location: Cytoplasm EC: 2.7.4.3
Q975K4
MKIGIVTGIPGVGKTTVLSKVKEILEEKKINNKIVNYGDYMLMTAMKLGYVNNRDEMRKLPVEKQKQLQIEAARGIANEAKEGGDGLLFIDTHAVIRTPSGYLPGLPKYVIEEINPRVIFLLEADPKVILDRQKRDTSRSRSDYSDERIISETINFARYAAMASAVLVGATVKIVINVEGDPAVAANEIINSML
Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 21447 Sequence Length: 194 Subcellular Location: Cytoplasm EC: 2.7.4.3
Q9HIT1
MRSVITGVAGVGKTTVLDIVSKETGIKIVNYGTLMFDLAKKRGLVENRDQMRKLSRDIQIDLQKNAATEIGRMEDVIVDTHMSIKTPFGYLPGLPEWVLREINASAFIIIEADPELILRRRQNDPTRARDEDSVESIREHQEINRAFAAAYSIFSGATVKIITNEEGKPDKAAHDIIKVIAVD
Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 20445 Sequence Length: 183 Subcellular Location: Cytoplasm EC: 2.7.4.3
Q5JJH2
MPFVVVITGIPGVGKSTITKLALKKTRAKFRLVNFGDLMFEEAVNMGLVKHRDEMRKLDPLTQKELQLKVAQRIVEIARKEPVLLDTHATIRTPAGYLLGFPREVIEILNPNFIVIIEAAPSEILGRRLRDLKRDRDVETEEQIARHQDLNRAAAIAYAMHSNALIKIIENHEDKGLEEAVNELVKVLDLAVSEYA
Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 22138 Sequence Length: 196 Subcellular Location: Cytoplasm EC: 2.7.4.3
Q54CT8
MALNLLRNYSTKIRMDHLRMTIIGAPGSGKGTQSEKLKKDYNLPIISTGQILREVSEQNTKSGIEIKSKLAAGELISDAIMSDIITEHLTKTGNSWLLDGYPRNTEQAKGLDKYLNVKMALNVVLHLDVPEKVLAERVQDRWVHPGSGRVYNSVFSPPKVKGIDDVTGEPLVRRSDDKDEEVFRNRIQTFKNNTLPLLKYYEDRGVLYTIDSPNSDEGYVKIKQILDSILTK
Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Catalytic Activity: AMP + ATP = 2 ADP Sequence Mass (Da): 26172 Sequence Length: 232 Subcellular Location: Cytoplasm EC: 2.7.4.3