ids
stringlengths
6
10
seqs
stringlengths
16
1.02k
texts
stringlengths
117
4.4k
A0A1Y1S259
MIPLTNYHTHNSLCDGTGELEEYLATARRKGFAALGFTSHAPLPFINDWTLAEADLETYCSRVRELQKNSDPELYLGLEIDYIPGRMGPAEERWKQYRFDYTIGSVHMIPVDGKAWSIDGPDDEFLHLYRNVYNRDGTAMAVEYYRLLEEMIHKGGFTILGHLDLIKKKNLKMHFLNEEAPRYTDAVLRVLDSLADSGIFMEINSGGLFRGATEGVYPSFSILQEARRRGIPLVINSDAHTPEALDFHFNEACDLARKAGYRRTMMLLNGDWREIPLGEA
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. EC: 3.1.3.15 Catalytic Activity: H2O + L-histidinol phosphate = L-histidinol + phosphate Sequence Length: 280 Sequence Mass (Da): 31913
A0A6H2FUE7
MKKTNIRQVVLDTETTGMNLSYPYYIGHRIIEIGIIEIINRNITQNYFHTYINPQKIISKEAFSIHGISNKFLSKKPIFSDILDNFLNFIKGAELIIHNAQFDINFLNYELSLLKKKTPKIEDICIITDTLKIARNIFPGKRNSLNSLCNRFNINISKRNLHGALLDAKLLAHIFLFMTTKQNSFQLEFLKEKNSIFKNKIKFLNAKSKIKKTLVINASKKELKLHQLQLNLIKNKYGFSLWENKNK
Function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease. EC: 2.7.7.7 Catalytic Activity: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)...
A0A9D8KAW3
MRSDLKDKKIGIVGGTFNPIHLGHLRSAEENREAFDLFRVIFVPSAEPPHKAGNIIDAKHRYRMVKRAIAANHSFSASDLEIKRGGKSYTIDTLIHYKELVGETGEIYFIIGLDAFREIGSWMRFRELFEYAHFVVTDRPDAGSKNPKFTIPGEIKSAFKKGAGGRGGFWTHTSGSKLYFQDISALDISSTTVRRLVKEGRSISYLVPESVEKYINKRGLYR
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. Function: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). EC: 2.7.7.18 Catalytic Activity: ATP + H(+) + nicotinate beta-D-ribonucleotide...
A0A366MJ50
MSGIAGIVDSRGVAYPLYYALHALQHRGQEAAGISTFDGRAFFMHKGPGQLSDVFCEKVLNRLAGNVGVGQVLYTQKAHRGRTENIQPFNFNFKDHQLSITVSVALINREALRSEYESKGHIFSSTTNAELIAAMIAHELIAGVSAEEAFVNTMQRLSGAYAGVAILDGVLYAFRDPIGTKPLCYGRTEFGHVVVSESVALDILSAAFEADVRPGELLTITEDGVSHRQVLESDHKAYCVFEYVYIARPDSVIDGVLVYDARRKIGACLATNPPKADLVSPVPDSGVAFATGYASESGIPYIEGLLKNRYVGRTFIMPTQ...
Cofactor: Binds 1 Mg(2+) ion per subunit. Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. Function: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. EC: 2.4...
B1H0L1
MDNKIKTALTNSDKNNIWHPFTQMADWLNDDPCKPLIIDRAKGSYLYDVDGKKYLDGISSLWVTLLGHKNPRIDKAVKKQIDKVSHTTFLGLTHKPAIDLSEKLLKILPDNLKKIFYSDDGSTAVEIALKMAYQYWQFKNEKRSFFLSLKNAYHGDTIGAVAVGGTDLFHSRFRSLLFKSFFAMSPYCYRCVYRKKEIKFPVTAENFKDHNIQMHCRGQCIKEVESILVKNNKKIAAAVIEPINQAAAGMIIMPKGYLKEYANLCNQYGIPLICDEVATGFGRTGKMFAVEHENIKPDFICLSKGITGGYMPLAVTATTN...
Pathway: Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1. Function: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only amin...
A0A357LBR4
IAAQLAFPNLFYFPDLPWTSFGRLRPLHTSAVIFAFGGNVLIATSFYVVQRTCRARLWGGLAPWFVFLGYNLFIVIAATGYLMGVTQSREYAEPEWYADLWLTIVWVVYLLVFLGTLLKRKEPHIYVANWFYLAFIVTIAMLHVVNNLAMPVSLTSTRSYSLFAGVQDALTQWWYGHNAVGFFLTAGFLGIMYYFIPKRAERPVYSYRLSIVHFWSLIFIYIWAGPHHLHYTALPEWAQTLGMTFSIMLWMPSWGGMVNGLMTLSGAWDKLRTDPVLRMMVVSVAFYGMSTFEGPLMSIRAVNSLSHYTDWTIGHVHSGA...
Cofactor: Binds 1 copper ion per subunit, denoted as copper B. Pathway: Energy metabolism; oxidative phosphorylation. Catalytic Activity: 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O EC: 7.1.1.9 Subcellular Location: Membrane Sequence Length: 433 Sequence Mass (Da): 49810 L...
R5FL66
MNEALFFIEIILTFGCVVAAKKIFGKAGLIAWIAIAMILANLTVVKTIDLFGIEATLGNIMFASTFLAGDMLNENYGRQAAHKGILVGLAGVLVFMVCTQISLLYTPSTSDISQEAMVLLFTLNLRTSIASVAMCVLANWLNVSLYAKIRELTNGKYLWLRNNVTTITCNCIENFLFVLLAFGGIYSMEQILAIALSTCAIEIFLALCDTPFLYLSRGESKLLSKVTASH
Function: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. Subcellular Location: Cell membrane Sequence Length: 230 Sequence Mass (Da): 25102 Location Topology: Multi-pass membrane protein
A0A1G1LV54
MQLSKLLQNITKEKIPSDVAHYDIRNVCSDSRKVIPNSLFIALKGFSQNGEDFIPDAVKKGAVAVIKSPSGSQSKSLTSRLPKDPNVFILEVEDTNKTLREIAAKFYDHPSSKVRTIGVTGTNGKTTTTFVIESILQKAGQACGVLGTINYRINREVFPAPNTTPDVIGIQQFLYNLMQKNIPYCVMEVSSHGLDQGRVDLIDFKVGLFTNLTSDHLDYHQTTEKYFLAKAKLFQNLSKGSHAIINGDDPLAKQLKAMTKAKVYTFGVSSDSDFKAVDITTDISHTSFQIKCPQGKMINIRSKLIGLHNIYNILGAVAAC...
PTM: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP. Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in...
A0A9D6KDK9
IPIFGLPGNPVSAMVTFDQFVRPALLHAQGGFRWLRPAIYATLTANIQKEPGRSHFVRGHLTIENGEYKVAPTGDQDSSNLVSLVKANVFIVLPEACGDLEAGKKVLVQIMTAPLF
Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. Function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. EC: 2.10.1.1 Catalytic Activity: adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin Sequence Length: 116 Sequence Mass (Da):...
A0A9D8KGZ9
MLATINWLRDFVDIDMDVEKLADLLTMSGLEVDSVTKIGDDLKGIVVAEIMDVSTHPKGGNLYVAKVSNGAETFQVVSAAPNTKVGLKTALAPPGVVLPTGLKIEKRDFKGVESTGVLLAEDEMGLTHDHTGLIELDPKAAPGKSLAETLNLSDYLIDIDLTPNRSDCLSVIGLAREISALTGAPLRLPKTDVKEEGPDINELTSIEVIDKDLCPRYVARVVQDIKIRMVPFWMRLRINQLGMRDINNIVDITNYILMEYGQPLHAFDYDLLSGNRIVVKRAKEGEKFFTLDAVERTLNKDVLMIADAERSVAIGGVMGG...
Cofactor: Binds 2 magnesium ions per tetramer. Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) EC: 6.1.1.20 Subcellular Location: Cytoplasm Sequence Length: 812 Sequence Mass (Da): 90150
A0A969KAZ6
MSIVENKVLAPYTSWRVGGPARFFTEATTTSEVRRALRWSQERTLPVLLLGGGTNLLICDEGFDGLVLRYRARSWALENQGTTGLLSLAAGTPIGHLAWIIGSQGWSNLEWAAGLPGSVGGAIYGNAGCYGGSMAGVLRRAWLLIEDQVQEWSVEHFAYGYRSSVLKQPRRFSSRRSEEGEGAPASDPDRTCPRPGAVMPAVILSAELVLKRQDAGSVEETMKAIIANRKERTPVGHSCGSVFKNPPGSQVTAGQLLDQAGLKGTRIGAAEISQRHANYLLNLGGARSDDILRLIELARNTVLRQFGIALELEIQVVGPV...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalytic Activity: NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine EC: 1.3.1.98 Subcellular Location: Cytoplasm Sequence Length: 322 Sequence Mass (Da): 34760
A0A366MDC6
MDDRSLLASIRHLIGEEETADDCAAFDLGDGRILVSSTDMLHETTDFPKGMTEFEKGWMSAAVTLSDIASCGAQPVQLLVAVGLDDPSRLVPFMEGAVSCAERFGAKVAGGDIDSHTELTVVTTGFGIVEKAHYCRRSGASPGDVVCITGTPGLAMAALEGDERYRKNLLNPGPQVDAGQKIAAVGASSMMDVSDGLAISLYDMAEASGVGFALDSAKFNLPDVRPGSAREYYLYGGGDFGLLFCISRERLPALDAEYTVIGTVVEENGVWYDGNVAEKRGYAHSW
Pathway: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1. Function: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. EC: 2.7.4.16 Catalytic Activity: ATP + thi...
A0A671S4P0
MAPFHAVKCCQRGLSWIPVIFINLVVCWSYYAYVVELCIYTISNTEEQVIYLLVFHVFFFMFIWSYWKTIISKPASPSKEFCLPKVDKELYEKEENPEAQQEILKRVARNVFIYTCTGSGAIRYCDRCQLIKPDRCHHCSTCDRCVLKMDHHCPWVNNCVGFSNYKLFVLFLAYSMLYCVYIAATVLQYFIKFWTNHLPDTHAKFHVLFLFFVAAMFFISILSLFSYHLWLVGKNRTTIEAFRAPVFRNGPDKNGFTLGFRKNVTQVFGDQKKCWCLPIYSSLGDGYTFPTRLVNADSEQGNAEHQAIKCTVDGQTNPRP...
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 360 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 41708 Location Topology: Multi-pass membrane protein
A0A968NBI3
MTDTGVILRAQSGFFWVQTADAVLRCRLRGRLKKDRQSSDIAVIGDQVDVEPTSPNEGAITHVHPRQSSFSRQQPGPRGQWREDVLIANLDQVVLVMACANPDWNARMLDRFLMIAEHNQIAALIVANKTDLLAPAQVAAMVQPYEQIGYPVFATCTPTGAGIASLREHLAGRVSVFTGMSGVGKSSLLNALQPGLQLATGAVSATLNKGRHTTVVAELHALPDLGGGYVADTPGIRELAAWRIPDADVAWCFREMRPFLGQCEFNNCLHTHEPNCAIQAAVATGEISPTRYESYVRILEKQERSG
Cofactor: Binds 1 zinc ion per subunit. Function: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyz...
F2I4T1
MLLTDSETLSVLKEIMVLFPDAGPSLNFNSVYQLLIAVMLSAQSTDKKVNEVTPDLFKAFPTPKHLAKASPLDIEPFINKLGLYHSKARYLHAMGQQLIDKYSGQVPSQRKDLESLNGVGRKTASVVLSLGFDQPAFAVDTHISRIAKHHHFVDPNATVREVEKRITKVLPASEWKDAHHALIAFGRTICTARNPQCYRYPQLLPHQEKETKRND
Cofactor: Binds 1 [4Fe-4S] cluster. Function: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the ph...
A0A101SXA9
MSSTSRRRTSHTPHHRTATLALAGVAALIAAAVQAGAASAAPAAAHRAGRIDPAHAALRLTPSQRAELLRHADAGRAATARSLGLGGKEKLVVRDVVKDADGTLHTRYERTYAGLPVLGGDLVVDTTGSGATRRVVRASNAVLDVARLTPAVPRADAGKQAVRRAEALGSTKSAEVSVRKVIWAATGRPVLAYESVVGGLQDDGTPNELHVVTDALTGKKLFEYQGVRTGIGNTQYSGQVTLTTTQSGSTYTLTDGARGGHKTYNLNHGTSGTGTLFSQSSDTWGNGTTSNAATAGADAHYGAQETWDFYKNTFGRSGIK...
Function: Extracellular zinc metalloprotease. EC: 3.4.24.- Subcellular Location: Secreted Sequence Length: 678 Sequence Mass (Da): 70639
A0A1F7G403
MDILLHTCCGPCLTGSYPLLEAGVGAGKAALFWENPNIHPFIEYQQRLASFKTAADHFKLEVIYGDASYGLEKFLRALDNEFGPARCATCYRLRLEATARAAAKAGIAAFTTTLLISPYQNHELLIKTGQEAAAQNGVSFHYTDFRPGFRGSQATARELELYRQKYCGCVFSEHDRYKNDKKYLNPVGAAGV
Pathway: tRNA modification; tRNA-queuosine biosynthesis. Function: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). EC: 1.17.99.6 Catalytic Activity: AH2 + epoxyqueuosine(34) in tRNA = A + H2O ...
A0A969FQC5
MMMRGRADVLLLALALDWLVGEPPDTLHPVVWLGRLAAALEQRAPRGSPPRELLYGAGMAAACLGVAALPALLVTALPLPAPLCLLEATLLKTTFSWRTLHHAGERVRQPLVAGNLEEARAGLRGS
Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis. Subcellular Location: Cell membrane Sequence Length: 126 Sequence Mass (Da): 13400 Location Topology: Multi-pass membrane protein
A0A2G5IJ77
MLQGSSWQQTSRQATCLGIDVVFVLPFTDLLANTTAEAFASKVIAERLRASVVVVGDNFRFGKGGRGDVDTLKRMGASNGFTVEAVGAVEYDGQTCSSTLVRNHLDIGDRASAEKLLGRPVTWRDACVTPTAAER
Pathway: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. EC: 2.7.7.2 Catalytic Activity: ATP + FMN + H(+) = diphosphate + FAD Sequence Length: 135 Sequence Mass (Da): 14451
A0A2H1W7H0
GVGLLPYTGHNSSLRAATEKFSKNRKKSSNTLPDTGIEPETSCPAVALAPTQPTRQSTYCLDAQVPDSACTATSYLTGVKTKYGVIGLDGNVTRGSCYSQLHEPNWSESIGQWALEQGLDVGLVTTTRVTHASPAGMYAHTSERNWESDADVPEECLAAGCRDIAYQLVTNSPGRHFKVIMGGGRREFLPNTTNILGSKGRRLDGVDLTDLWHVDKLNMNATHQFVTDRLELLKVFNSDDLPEYLLGLFRDDHMEYHLKAQNQPSLEEMVEVAIKMLSRSSKGYFLFVEGGRIDHAHHDSLAHLALDETVEYSKAVKKAR...
Cofactor: Binds 1 Mg(2+) ion. EC: 3.1.3.1 Catalytic Activity: a phosphate monoester + H2O = an alcohol + phosphate Sequence Length: 396 Sequence Mass (Da): 43285
A0A671RCF5
MRHQHLLSNYNSHDTRNRTTEANMAAVGRFLKNAWNKEPVITVSCGIGLLACLLPALSPLTKYTGMMNRAIPYNYPVPVRDDGNMPDVPAHPSDPQGKNLDWLKNL
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ...
A0A2T2SGM7
MDDNALPQNGTLQSGSFSENGEGPANNEQIVVGVDIGTTKVCAVVASTDARDRVNILGVGMAESKGSNRGVVVNIDKTVDAVQEAVGEAERAAGISVESVIVGIAGDHVQSFQSRGVITISRRNGEITQDDVQRLLEDTMHVAMPADREILHVVPQEFIVDGQDGVADPVGMSGVRLEANVHIITGLVSAAKNVFRCIEKAGFEVADIVLEPLASSFAVLHDDEQEVGTALIDVGGGTTDVAVFEDNTIRHTAVIAVAGDKVTDDIRKGLGVMREHAERLKRRFGTSLIDYAGEDEMITIPGIGGRSEKSIGRSALAQII...
Function: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Subcellular Location: Cell membrane Sequence Length: 451 Sequence Mass (Da): 47554 Location Topology: Peripheral membrane protein
A0A1Y4BBF4
MLSLDGWTLFFTVLNVIVLFVGLRLLLFKPVLKIISQREEMIKTQLKEAAAKEQQAEQLKNDYQEKLKDAGHKAEEIIAQAKSRAAREQSEAAVKAKEEAEKMLEKAREEIRTEQEQARKEVQADIAILAMEAARKIMKTGDVHDAAGK
Function: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). Subcellular Location: Cell membrane Sequence Length: 149 Sequence Mass (Da): 16847 Location Topology: Single-pass membrane protein
A0A366MH62
MKSLLISGDRSGAGKTSITLGLAGLLAKDAVVQTYKVAMDYIDTSYLSGVTGRPSYNLDTFVQTDEELAGLFSYGAKGADIGIVEGVRGLYEGRDSFTDVGSTAAIAKRFSLTTILVVDARSITRSAAALVKGFQAFDPDVRIKGVILNNTGGGHHVTKATEAIEYYCGIPVLGAVPRSPEMDLSMRHLGLVPFVEGMRDPGFAKTIEGIIRHVGAHVDLEAVKAIAEDVTPEPNLVTESLASRPAASRRIAVAFDEAFTFYYGELEAVLRSQGCDVVRFSPLHDTLPEADGYIFGGGYPEMFAEELSKNVPMREAILAK...
Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10. Function: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. In...
A0A671MT42
MSELSSKKQGFKKCRSATFSIDGFSFTIVANETGESSARPLARFARSKSQNALWNAITAGIGIKDKDKRGILIDPRSPEEILADDLPSVDSPDAMEKTAIRLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHVVQAGIFVERMYRRTSNMVGLSYPPSVITALKHVDTWSFDVFTLNDASGDHALKFIFYELLTRYDIINRFKIPVSALVSFVEALEVGYSKHRNPYHNLIHAADVTQTVHYLVLKTGMVHWLTELEIFAML...
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. EC: 3.1.4.- Catalytic Activity: 3',5'-cyclic AMP + H2O = AMP + H(+) Sequence Length: 696 Sequence Mass (Da): 78808
A0A6V7XAF6
MFPDLEYCIPVESSSIHFLKLPDEFYQEILKRISASKSRIVFAALYLGAGQKEQQIVSRLQTACSENVELEISFLLDYFRGTRGEPNDSSTSILKPLLENRNVQVSLFHTPEMRGLLKFLLPGRLNEIIGVQHMKFFIFDDSIIISGANLSDQYFDNRQDRYLVVENCPRLADFFHSISTIMAKHSMQLDKFGKLNFSGSASIHPFTGSNEEIQKSIKTEIFELFDKCKDNVNNLANDTFIYPFLQMGVFDIKQEENIKEINLITAYFNLCDEYADWMLQKRSFLVNIVFGSPRTNGFYGGTGISGSVPLLYLQNSLDFI...
Pathway: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. Function: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-...
A0A2K6QAX3
MFVSRNALIETAIFLFQISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
Pathway: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. Catalytic Activity: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine EC: 2.4.2.8 Subcellular Location: Cytoplasm Sequence Length: 226 Sequence Mass (Da): 25663
A0A7S0X5K7
DDVERAPLPSPRTGPDRPGRGSVHGKSPRITRQLVMWLAAARPKTLTAAVVPWLVGSALAAAGGGETQWLHSLAALLAYFFIQIGTNLVNDACDFDRGADTKERTGPIRVTQAGMFTSRTVHAAGVGCFLFAGVAMSPAIFHRGWPLALLLVSSCAAGYAYTGGPYPLGYHGLGDVTVVVFFGIVATGGIRYIHGGGDFLSVPIAVASVQVGL
Pathway: Quinol/quinone metabolism; menaquinone biosynthesis. Subcellular Location: Membrane Sequence Length: 213 Sequence Mass (Da): 22188 Location Topology: Multi-pass membrane protein
A0A6V7W2R1
MINNKKILFFVNNQIIKLINNNNLKFQYKYFSTTNLIKNEVKQNFKENSSLIDSFGRFHNYLRISIVEKCNLRCKYCMPEEGVKLTPSSDLLTKDEIIRLAKLFAFEGVNKIRLTGGEPTIRKDLVEIVSELSKIDGIQEIGITTNGIVLNRMIKPLIDAGLTNLNVSLDSLSAQKYAEITRRDGFQKVWRGLILSEQLMPKGKVKINCVVIRGINEKEVISLVEIGRELSFNIRFIEFMPFAGNNYEMKKFVPYREMLENIGKYYGVENIERLIDGPNETSKSYQVKGFVGKFGFISSMSEHFCGGCNRLRITADGNLK...
Pathway: Cofactor biosynthesis; molybdopterin biosynthesis. EC: 4.1.99.22 Catalytic Activity: AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine Sequence Length: 323 Sequence Mass (Da): 36924
A0A4Z2CUY0
MLIRLWDWENNWTCAQVFEGHNHYVMSLAFNPKDNNTFASASLDHTVKVWNLGSGTPNFTLEGHDRGVNCVDYSTSGDKPYLASGSDDRTVKIWDYQTKACVQTLEGHAQNISSVLFHPELPIILTGSEDGTVRFWHANTYRLESTLNYGLERVWTMTCQRGKQIVGIGYDEGTIAISLGRDEPAMSMDASGKLVCARHAELVQANLRSLNFSGEGGEAIQDGERLPIAFKEMGTSDIYPQTIEHNANGRYVVVYGDGEYIVYTAMALRNKTFGQGLEFVWCQSDAGVYAVRESNAVIKVYKQMKEIRTFKLDYGAEQIF...
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membra...
H3CI64
ALDPGGCLQVSETGKESLPGWLHWNASSGTLLGVPLEEDRGVHHISVSTYSDATSSSSEVFSIEVHPEDVLEPDSSLRASADAQTFLCEGEEPVTVLTVIMDADLNKMSSGQRVALLDNMRKFSGVDLQHMKMLPVVNNRLFDMSAFMAGPGNAKKVVENGVLLSWKLGCSLDQTTVPDISSIQGPAKAGTMSAKLGYPVVGWHVANKKQHLPKRVRRQLSNTPTPVLVVPPPTTVVEPPVRIVPTLSSPSAAAPTETSAPPVRGPVPLPGKPTSRFREPVAHTPTLAPPQPTRVAETTSTLPIQPTMTRPTYVEATATP...
Function: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Subcellular Location: Cell membrane Sequence Length: 774 Sequence Ma...
A0A6N4R9C1
MSSGTQSQTTNKLKAPKPAAKVVAPARPSSLLEDYPKLNGLTPAQYIKLQTLCGPRWIDLLFHLPTKMLDRSATPTIAAAPVGETVTLIVQVTRRQPLPPRHIKRPMTIDVTDGSAPLRVMYFNPGYWLERAYPVGETVILSGKIEVDNKGRKLIHPDVWSLPKSEDTASNKINHVARIWPLYPLTAGLGQGWLSRAILTALEVAEDCPLPEWLPASLREQHNLPTFTDALKAAHNPQTEADLQPNSPARTRLALDELYATQLALQHARAANRGQRGIAHGKSDTLTQRLLQSLPFPLTGDQQNALTEIRADLSAPRPML...
Function: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Catalytic Activity: ATP + H2O = ADP + H...
A0A931FBA7
MADKEILVITGETSGDMHAAKVVARIKELTSGVKFSGLGGRELDYLKLENLLPSEEIKTGSHGFASGITGLFSHIKLAHKITDLVADRDIAVCFLVDYSGFNMYLGRRLRKKLDLPVIHYFPPTAWIWGRWRAKWLASAGVKVAATFPKEADVYREAGAEVKYVGHPLLDEIPESRDQADAREELAELIKLAGRRELQLGERLLAIMPGSRPKEVETHLGPMLAAADQLAHDFALRPVIPVARGIDIEQVEEKIENHRINPVLLSGYSRELLAAADLALVVSGTAVLEAALLGTPQLLIYRADKLTAFLGKYLIGPEYIG...
Function: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. EC: 2.4.1.182 Catalytic Activity: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydrox...
A0A0G1WQ52
MALSEKEVIRTAELARITISEDEKKRFGDELTAILDFVRELNEVDTEGVSPMTGGTREENALRPDEPLSDALEGAGADLLNAAPGKKNRYISVPAIFE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an ...
A0A1W9VM55
MEDFKDKNVTIMGLGLHGGGLATAKFFLAEGANITITDLRTKEILKQTIEQLKGEKINYTLGEHIDSDFTNADIVIKNPGVPKTSKYLKLAKRVESDISIFLQRVNTPIIAITGSKGKSSTVSAIYHVLKKFNPKTRLGGNITVSPLTFINDVDETTPVILELSSWQLADLNGKGCLKPKIAAVTNIMNDHQNAYNSLDEYAEDKAVIFQGVTDYAILNYNDKYRDFFKSRLNIKPLYYSNTEEPSHINGIYLDSANQGWSNIEGKRELLLDPQLTLKGEHQRENLLLAALILSLYGVDKKSIRTGLQEFKGIAHRMELF...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Catalytic Activity: ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-...
H3CZE8
MAKGKFFYAVKKGLQPGVYTTWDECKSQVDKFPSASFKKFASEREAWAFVRGAEPSAPPGTNKAVESGVGLLPKRGPEALEYIPLGKKRSHSGEDEEEAQAKKVKHSGTSSSESTDGFTYMGDAVVVYTDGCCSANGKVGARAGIGVYWGLNHPLNVAERLPGRQTNQRAEIQAACRALELAKEQNIKKLVLYTDSKFTINGVTCWVKNWKLNNWRLKSGGSVTNKEDFEKLERLNAGLDVVWMHVPGHAGYHGNEQADRLSREGAAKPEVQQGNG
Function: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. EC: 3.1.26.4 Catalytic Activity: Endonucleolytic cleavage to 5'-phosphomonoester. Sequence Length: 276 Sequence Mass (Da): 30178
A0A1V5W8R4
MKFTVKIAVFSLFISACSDKQDRINTNIHHSQITITYLPPVQKKNKLLPFEVLLVNHGFVNMQHIDSSIQCDLRYSTTHNFVGIDMYGDFNACYVPRDIALRLHRVQKQLQAIDSLYSLVILDAVRPLHIQQIMWDSCSYSGRQKKNFLAPPSQTSLHNYGAAVDVTLAYNGSEVDMGTAFDYAGEAAYTYIEQELLTYNKITREQLYNRTLLRSVMKQQGFIENKYEWWHFGACYRSQVAKKYPLVLSFDSIVPNHQF
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. EC: 3.4.13.22 Catalytic Activity: D-alanyl-D-alanine + H2O = 2 D-alanine Sequence Length: 259 Sequence Mass (Da): 29923
A0A1V5W610
MNLTSLYAIIVAGGKGMRMQNDIPKQFLILSGKPVLQHSLEAFYRYNNSIQCIVVLPKDQISYWQQLCVDYNCMVPHTIAEGGSERFFSVLHGLQYITSHGFVAIHDGVRPLVSNEIIAQGFAYAQQYLAAIPVIDSVDSLRYVEKNTTYVVNREPIKRVQTPQVFETKTLLHAYTLGYDLHCTDDAAVWEKAGNTVFCYKGDEKNIKITTPLDLCTAELLINM
Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. Function: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). EC: 2.7.7.60 Catalytic Ac...
A0A9D8PNC3
MEIVMPDIQLLALAPEIILIIVAFLMLFFGPLVGGPNTKGGPKVGGIVSLVALTGAFLINLYIGQDEIVTLGGMIVKDAFSLYFNALVIIAAAFSIIISFGYINRFGIKEGEFYLLILFSTVGMMLMGSSADLLSIFIALELMSIPIYVLVGFRKENLRAREASFKYFILGAISSGIFVYGAALVYGSLGTTNLTAMAEALGSNISPVFLLGSAFIISGFLFKISAVPFHMWTPDVYEGANLPITAYMSVGVKAAAFSAFLRFAVVDLANTGDSWVLAIGFVAVATMSLGNTAALAQKNLKRLLAYSSIAHVGYILVALV...
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ...
Q4RQD8
MERFALKQSQLCGSWEMKERLGMGGFGHVYLYQHLESGEKMAVKLCRLELNSKNRERWSREIQIMKKLKHTNVVQAREVPEELTSISINDLPLLAMEYCSRGDLRKVPSGYFIIENHVVVFSEVASLSFVYSFFQILNKPENCCGLKESEVLSLLSDIGSGVQYLHDNKIIHRDIKPENIVLQENDGKLVHKLIDLGYAKDLDQGSLCTSFVGTLQYLVVRETKTQLPLTALRKVWGEAVSYICGLKEDYIRLYSGQRAAILSLLRYNTNLTRYKNLLFSCSQQLRAKLAFFKTSIQQDLEQYSKQSQSGISSEKLLRTW...
Catalytic Activity: ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein] EC: 2.7.11.10 Subcellular Location: Cytoplasm Sequence Length: 494 Sequence Mass (Da): 56797
E1QZZ5
MEELKDIREEIDRIDDGIIDLFMRRMDCAEHVASYKAAHHMPVLDKSRERDLLAKVAERVPHEMRSYIEVLFQLLMEASRNRQDRRLGRQSATADDIERALGAAPELFPARAFVACQGVEGAYQQMAADRIFRHANLAYFDTFDAVFRAVEEGFCRYGVLPIENSTAGSVNQVFDLMMRHNFHIVRTCRLKIDHNLLAKPGTGLEGIHHVYSHEQAINQCGEFISSLRGVQVHACENTAMASRMVAESERSDVAALASRTCAELYGLDVLARSVQDQGNNYTRFACIARDLAIYPGADRSTFMLVVSHEPGALYKILAKF...
Pathway: Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1. Function: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. Catalytic Activity: H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O EC...
A0A9D8KDX0
MSVINVAIAGNPNSGKTTIFNALTGSRHMVGNYPGITVEKKEGKIKIEGREVNFIDLPGTYSLTAYSLEELVARNFIVEEKPDMVVDIIDSSNLERSLYLAVQLMEMNVPLILAFNMTDLAELRGIEINVEELSGLLGIPIVKTIGNKKTGLDQLKRTIVMVAEGKIESTPSKIYYEDRVEEEIARLAEIIEKSSLSESGFSPQWLAVKLLEHDTEVEKRLSEDEKWEEIETALEGSRENLLKVLKEDSVNLIAEGRYGFIKGTMKKAVRHIREDHIIVSDKIDKVLLNNLLGIPIFVGVMYIVFQGVFKWAGPFMDLID...
Function: Probable transporter of a GTP-driven Fe(2+) uptake system. Subcellular Location: Cell inner membrane Sequence Length: 794 Sequence Mass (Da): 87940 Location Topology: Multi-pass membrane protein
A0A0K8MED0
MRFGALLYRYFFRHSSKNAKLLFVMLFFVTSVFLAVVVDYFFPVDTSRFQDISIVVAAEDKPLAHVFQTKDEKWRLGTSLKDVDSCFIKQILYREDRYFWLHNGINPFSLLRATSQWLINGKVISGGSTLTMQVARLLEPRPRTLSSKFIEIFRSFQLEWHFPKSQLLQMYLTLAPYGGNIEGIQAASWRYFGKSAQHLSPSEAALLIALPQAPRRYYHHSFTLSALQARNRILVQLHEAGFFDKATLMAAQDEPLPGQRFALPRYLPHLAYRLKRLLPQQKKIETTVQISLQNKIQHLASQALNIYPSGVNIAVLVVHH...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. EC: 2.4.1.129 Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [...
A0A1V5W9B3
MTRYKLAIEYDGSQYKGWQILHNEPTIQGKLIEICSKICKTNTIEVYGAGRTDAGVHALGQVAHVDADTNIPPNEFHNQLQAFLPSNISVRAVEIAHNRFHARHHATYRSYLYCITKERTALFKRYVWWIKNSLNVEQMNIAAQEFKGFHNFKSFGKSSKNEESTMVEISHIHIYEVQNCIWIHIVGSHFLWSMVRRMVGTLAEVGKGTLQPNDIKTFLQESSNFPARHTAPPSGLFLEQVYYSKHIDIQKPQFPFII
Function: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. EC: 5.4.99.12 Catalytic Activity: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA Sequence Length: 258 Sequence Mass (Da): 29735
A0A5C7EZ96
MHITFIGGGNMATALIGGLLAKDWSASQIRVVEVDAAARERLTGRFGVATTEAPEVDGSDTVLLAVKPQQMHEVARRLAGRLGSQLVLTIAAGIRLDDLARWLGGYQRLVRCMPNTPALVHCGVTGLYALPQVSREERQRAEAILGAVGRTVWLDREELLDAVTAVSGSGPAYVFYFMEALEEAASSLGLSREQARLLVVETFLGAASLARQSEEPLAALRARVTSKGGTTERAVAVLEEARLRDHIAQAVRAAHARSRELGDEFGKLG
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Function: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Catalytic Activity: L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH EC: 1.5.1.2 Subcellular Location: Cytoplasm...
A0A4S4BPT7
MLWMVTGGVGCGKSVYAERWAASLAREAILLSCPTWPNEREDLVGGRPDESALMEEERVVWMRWKADEKLSDRIDQINLKSNPFRADNRVIVLDSLSGWLRRAVREVRQMTLPPAPAEPPRRGRPKRIPETEDLFALRTDRAGKEFRRVVDALLRYHGRSIVVTEQPAPGLADDPWERWYARELAEANRRLAERSAELRMLVSGVAVEIRGPRMKRGNGNDEDLYSNRR
Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7. Function: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. EC: 2.7.1.156 Catalytic Activity: adenosylcob(III)inamide + ATP = aden...
A0A381H8C3
MIYSLATGGTVSIAALFIAGILPGLLLSFTLMVMCVGFAHKARYPKGERVPFRQALKIFVDTLWGLMTVVIIMGGILSGIFTRDGIGGDRLSVGLLRHYVYLPRLQMV
Function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system. Subcellular Location: Cell inner membrane Sequence Length: 108 Sequence Mass (Da): 11773 Location Topology: Multi-pass membrane protein
A0A4S4NN58
MSRPLFIVIEGLDGSGKTTQLEMLRDYLQSRGESCRLTAEPTDLPTGRLIRSILQKEISVDPRTLAALFAADRVEHIFHPESGILDLLAAGHHVIASRYYFSSLAYQSEFVDPGWIAALNRQAKTALPADLTIFLDLEPTESMQRIAGRNGEDELYETLEKLTHVRESFLAAFSVFGEGENIQYVDAGQPVVAVADAIIEHVEALR
Function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. EC: 2.7.4.9 Catalytic Activity: ATP + dTMP = ADP + dTDP Sequence Length: 206 Sequence Mass (Da): 22842
A0A2H6HXQ1
MNGKNGQTDGNGINGSNGHGIGGGNGHGGSRRALITGVTGQDGSYLAELLLAKDYEVHGLIRRSSTFSTGRIDHIYDDPHRAQVNLKLHYGDLTDSTGLRRIIEEIEPHEVYNLAAQSHVRVSFDQPEYTADVVATGTLRLLEAIRDYMAISNNRPRVYQACSSEMFGSSIPPQNEMTSFHPRSPYAVSKVASYHYAVNYREAYDLFVSNGILFNHESPRRGGTFVTRKITRALTRIKLGLQEKLFLGNLDAKRDWGFAGDYVEAMWRMLQHDRPDDFVVATGETHSVHEFLESAAGVLDMDWRAIVEFDSRYLRPSEVD...
Function: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. EC: 4.2.1.47 Catalytic Activity: GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O Sequence Length: 377 Sequence Mass (Da): 42265
A0A2H1X0S9
TDIKFFFKILALCHSVQVSNEDMKKLSARLSVTGNMQLMNFFKRKKIKTNNTNGSVVDNVTWNSIINENGNKIDYQASSPDEKALVEVAERFDITFLGEEGNDLVLKVGEHTEMYERLQIIEFTSERKRMSVILRDRDGKIWLYCKGAESSVFPLCTNYSCVQETDRDINIFANKGLRTLAIAYREVPEEEYEKVAEAIKRLDGKSAEALQQVTQQYRTLERNLTLLGATGVEDCLQDNVADTLASLRAAGVKTWVLTGDKVETAINVAQSCAHISENDRRMFMIGIEDSTTLQAHIGECSRIINEPSYRDLTLVVDGTS...
Catalytic Activity: ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2. EC: 7.6.2.1 Subcellular Location: Membrane Sequence Length: 504 Sequence Mass (Da): 56835 Location Topology: Multi-pass membrane protein
A0A932QW80
MNVADSELIRSILIAKGHQMTSSANDAEVVLMNTCAIRENAHRKIYGRLDILRPLKKQREAEHRPFVVGVLGCMAQNLKEELLMHPVANLVVGPDNYRALPNLIDRIVQTNHHEVEASLSEYETYSDIAPTRIEGVNAWVTIMRGCDNFCAFCVVPYTRGRERSRSIPSILNELEQLVAAGYPQVTLLGQNVNSYCHEGETFADLIVKAAQIPGLKRIRFTSPHPKDFSEKLLYAIAEYPNICNHIHLPLQSGSDRILNLMNRTYTSAEYLGLVKTIRRVIPTTTLTTDMIVGFPTETEKDFQETVQLMDAVQFDNAFIF...
Cofactor: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Function: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that re...
F9ZAF5
MADTSNKKNIREESLRDLSDFLTAQGEKAFRAKQIWQWIWQRGVTDFAEMSNLSKATRELLSRHYFFDSLFPQQVQTASDGTEKTAWRLTDGEIVESVLIPGNQKFTVCVSSQVGCQLGCKFCATGTLGFKRNLTAGEIFEQVVRAQQAAEAQGQPLSNIVFMGMGEPLLNYEQVLRAIERITAQDGLAMSPYRITVSTAGIPEKIRQLADDGVRFNLALSLHAAKETTRTFLMPVNKAYPLSEIAGSLKYFVEKTGTRPTFEYLLLKDINDSLEDAKALALYCRQFPIKINIIEYNNVEGSGFHHSPDKNRDAFIRFLE...
Cofactor: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Function: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. EC: 2.1.1.192 Catalytic Activity: adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-...
A0PZR1
MSKVKVARFASQVMIITILSKLMGFWRDALIAKEFGTTYETSAYMMSLNVSSILFGLMGLAITTTFIPMLTRSLREKGKDDMYEFGNTVINIIIILTTIIGVLGWKFAPQIVKIVACGYTGEIYDLTVQLTRLSVINVVFIGLTSGYTAILQTMDNFAAPSLVGVAMNICIIIYLLFTKNTTIEGLTIATIIGNGSQILVQIPWLIKNKYKYSCKINFKDPRLKEMMTLILPVLIGIGINQINTLVDNNVASNLNEAAVSVIQYANRLNSLVYGIFATSIITVIYPTLAKYINAGEIKEDFKKYLSKAINNINLIMFPAT...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. Subcellular Location: Cell membrane Sequence Length: 515 Sequence Mass (Da): 56524 Location Topol...
A0A4R1HAJ2
MSIRAVSFLALALLLATACQPQPEVVYRQQLFAFGTLIDITTQGVDAAQSRAAVQAVDAMYQQQHRDWHAWQRGALDDLNNAIAAGKSWQTDSSIVKLIRMGQNFERLSGGLFNPAIGELLALWGFQQDEPEGPPPSPQRINAWLSHKPSSLQLTIDGNIVSSQNPHVRLDFGGFAKGYSVGKAVELLEGRGIHNLIINAGGDLCLRGNRGGNKPWRIGIRHPRNTGTLATLELQGAACVFTSGDYERYYIYQGRRYHHILDPRSGYPATATRSVTVIADDPALADAAATALLIAGAEHWQSVAVNMGVTDVLRIDDQDV...
Cofactor: Magnesium. Can also use manganese. Function: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. EC: 2.7.1.180 Catalytic Activity: FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H...
A0A1H4CIQ7
MPKGFSLQELAEYTDSDIRGDAQLRLYSVASIEKAVSGDLSYIRDAKYRHYLQTSEASALILPTDMAQTYQGNCLVNPNPYLAYAKAVTLLYPAVRPAVLIHPSVVIGDGVELGADVVIEAGCVIGDGCVIGDGSWLHANVTLYADTYIGKRCIIHSGAVLGADGFGFAPDQKTWFKIPQVGNVVVGDDVEIGANTTIDRAAMGSTVIGNGVKLDNLIQIGHNTQIGDYTAMAACTAVAGSVQIGRYCQIAGMCAIAGHLSITDHVVVTGTSMVSHSITKPGVYSSGTTIEENAVWRKNAVRFNQLDKLARRLQELEKQL...
Pathway: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. Function: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell....
L2GW45
MSSTVYASFVNSILSTLYPILTIYSYYVLVGKYCIDAKRFDSVVVLIMFLIYHVLLIYTLIFYMRILAIDDTSTANRFPSKVANKQAITSRYFNPFIEEEIIQKRLKMLKTCNICVTYKPPRTHHCSICQKCFLRFDHHCGLLGVCIAFHNYKFFYLFVIMNIIYCLFLIILLMFELIKNRQLPTASFSHFIVLTSLLFVEMCVSLQMFIYHTILIRKNETMIENKALNAFLRGDQGVRFVYQEGPLVNEEEVLERDEMNPYNMGVYENWEQIFGKNTWEWFLPTFTTLGDGINFPKKIGRD
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 302 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 35573 Location Topology: Multi-pass membrane protein
A0A6V7V4Z8
MDEKHQQQSPIIMDNLINNNGENSSSKISSPLLDTGQSEDPSICPYCNKKFRKPRVLDCLHSMCEDCIIAQLDDGRNNQQRNSKNILNSFMELELEDSVAGRRPTPPGVICCSVCNQETHIGNDPMFVNLMLLDFVKIREYGFNDANDTGRICEACKSEEKAVANCIHCCSDLCPKCVQVHRDMKMFDGHKVVMFSEKDKLSNQQEGLLKEGGMETIKLALCNKHKGDFELICPSCDELLCKQCAFEHVEHNVSPLNDLVFKWYKQSIHDLAKQAENKGRTTLDARSAIPDRKFLLQQSYHKCRDKIEDAFQFYARVIDE...
Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellular Location: Cytoplasm Sequence Length: 983 Sequence Mass (Da): 110621
A0A9D8KFE6
MSEILKFKSPAKVNYFLKVGEKLPNGYHKIATVMSAIDIYDHITVAFEGSRIEIESDNTKVPQGPSNTVYRAIEALLKEANVDIGIKVNIQKNIPLESGLGGASSNAASVMLKLNDHLNLGLGLDELLTLGVKIGSDVPFFIFGSPALVTGIGENLKKIEGIPETWMVVVKPPGSVSTKLAYKMIDLVLTFNKKSIIIPKFNGTLGGLIEGMVNDFETVVGVEPIVNDKRNDRDRDGGGYSVYLPEVGRIKREIERLGSLKAMLTGSGSSVFGVFGNRIEAKRAFEEIRSKNDWTVFLAQNLFY
Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. EC: 2.7.1.148 Catalytic Activity: 4-CDP-2-C...
A0A951BRS6
MTGSTSRSTRRAPSACSTASWKRRERTGAEASVSGLGPALESVALDVPEAAVPAYEAALRTACGSVGLFRDEASGTWRLEGVKPAGAGEAALAAGLALAAAATGVDARARRGPIAAEGWLARSMAGFPEQTVGRFAIRGSHLPDRPRAGRITLRLDAGVAFGSGEHGSTRGCLLALERVARRRPGRTRVWRILDLGTGSGVLALAAARLLRRPVLAVDVEPWSVRTAAANAGRNGLRPRIRCRLGDGWRDRAVRAGQPYDLVFANILARPLCAMARDLAAGLAPGGRAILAGLLVSQARQVLAAHRRQGLVLEWMVNEGG...
Function: Methylates ribosomal protein L11. Catalytic Activity: L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine EC: 2.1.1.- Subcellular Location: Cytoplasm Sequence Length: 335 Sequence Mass (Da): 35275
A0A671Q3P0
KKHLLLSILKTVVVIKNLLQFEDMIKCTVPDSSPLLDFADYGCFCGLGGTGTPVDQLDQLVSFVIFSENVYIIYIYITLFVLNHFVLIIFFL
Cofactor: Binds 1 Ca(2+) ion per subunit. Catalytic Activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) EC: 3.1.1.4 Subcellular Location: Secreted Sequence Length: 92 Sequence Mass (Da): 10435
A0A0N1CTT3
MIEMKDIMKKYSNGTTAIRNLSISIDQGEFVYVVGPSGAGKSTFIKLMYREEKATKGVLNVAGYDLVGMKSREIPLMRREIGVVFQDYKLLPRKTVFENVAYAMQVIGRKPRDVKKRVMEVLDLVGLKHKVRVFPSELSGGEQQRVSIARAIVNTPKVLIADEPTGNLDPENSWEIMKLLDRINAQGTTVVMATHNSTIVNTIRHRVIAIENGRIIRDQAEGEYGYDD
Function: Part of the ABC transporter FtsEX involved in cellular division. Subcellular Location: Cell membrane Sequence Length: 228 Sequence Mass (Da): 25641 Location Topology: Peripheral membrane protein
A0A1Y1RZY8
MSAIPPERLVFHSLHAAVDWILKHPNAREDLQKAIDKGALSLRQGKLTAFPTETVYGLGADALNRDAVKLIFKAKQRPFYDPLIVHISELQQLDTLVLEFPEKARRLAEAFWPGPLTLVLKKDSRVPDIVTAGHPTVAIRMPSNPWARELIHRAGTPVAAPSANLFGRTSPTTAAHVAEQLSGSYEVLIDAGACRVGLESTVLSLAGERPLLLRSGGVSREQIEEIIGPVEVPAKTRAGDAESPGMLPNHYAPVTPLLMVEDVRDYAENRDIGCILFEKPDIDFQGPTVQVSGNRNADEIAVNIYAALRSLDGKGLRLIV...
Function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalytic Activity: ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate EC: 2.7.7.87 Subcellular Location: Cytoplasm Sequence Len...
A0A109ULC2
MQRNQLADAGIGLGETLGQVVALHGPTGNADQGRRLVLNELRLRALDLHDDPALEVLDLRGCGRQHYLHLQLDRLPHLREIYLPCLAEGAILHLFNLDVPASLTVHGRVREIDADWQKGTLRLTHRQRSWEGVQLLGHDAKPDDLVDPPLAFPLNVVLSSELLQAATMDGALCLSGQGEWMDGFQPLRMGQRLWIVPSWHQPPDPDAVNLHLDPGLAFGTGTHPTTALCLEWLDGLSLTGELDERAVLDIGCGSGILAIAALKLGAGQAIGTDIDPQALQASRDNAARNAIADEDLRLCYPEELAESGTATTFPVVIANI...
Function: Methylates ribosomal protein L11. Catalytic Activity: L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine EC: 2.1.1.- Subcellular Location: Cytoplasm Sequence Length: 384 Sequence Mass (Da): 41441
A0A1F3EPK3
MAHSDGDVLLHALCDAMLGAAKMGDIGRHFPDTSSDYKNIDSKILLAQTNELIAAKNYRVGNLDVTVAAQQPKLKPFIPEMEETIARILGIDVDAVSIKATTTEQLGFEGREEGISVHAVVLLETLS
Cofactor: Binds 1 divalent metal cation per subunit. Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6. Function: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP...
F9ZC24
MIQETIKNFLQQHHISRDAGFILAVSGGADSICMLHAFKYLNLKMLVLHCNFSLRGKESDMDEQFVKRFCDSYGIAHSVKKFDTLKYARENGLSVEMAARELRYTWFREMKEKKKMDYIVVAHHADDVAETVLINLCRGTGIKGLTGIKSINGDILRPLLPCSRTDILKYIEDHQLGFRTDSTNNSLDYVRNKIRHQIIPVLKEINPSFLDTMTENCETLKETEEIFQYGIHRFQEEILDCEEDELLIHISKTLATPAPYTFLYETLKPFGFNKVQIRDILNTHTAIPGKQFIAGHHTLERGRIFWRLYDNSKCSRTIVS...
Function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Catalytic Activity: ATP + cytidine(34)...
A0A0C1S0S2
MNIKIFSGNSVIKLSKNISKHLHTNLGDASVGKFSDGEINVQINESVRGKDVFIIQSTCYPANDHLMELILMIDALYRASSKRITAVIPYFGYARQDRRVGSSKTPITAKIVANILSCVGTSKILTVDLHTDQIQGFFDIPIENISGNDVILKDIESKKLYDPIIVSPDIGGIFRARMVSKLLNNMEIAIIDKIRSRANVSEMVHIIGNVKNRDCIIIDDIVDTGSTLCQAAEILKKNGAYKIFIYVTHPVFSGNSLKNITKSSIDEMVVCDTIPVSEKINGLGKIRSLTLSFMLAESIKKINNEASYCSIKTFNK
Cofactor: Binds 2 Mg(2+) ions per subunit. Pathway: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. Function: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-p...
A0A101ST62
MSELAVRAEKLDGADELAPLKSRFVLDGAVYLDGNSLGALPAHVPGRVEDVVRRQWGELRIRSWEESGWWTAPERIGDRIAPLVGAAPGQIVVGDSTSVNVFKALVAAVRMADEGRDEILVDATTFPTDGYIAASAARLTGRTLRAVTPAEVPAALGARTAAVLLNHVDYRTGRLHDLPALTAAVHAAGALAVWDLCHSAGALPVGLDEHGVDLAVGCTYKYLNGGPGAPAYLYVRSDLQDRFDSPLPGWNSHADPFGMDPSYAPAPGAPRGRVGTPDILSMLALEAALEVWDGVSVEAVRRKSLALTDFFLECVTACTE...
Pathway: Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. Function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. EC: 3.7.1.3 Catalytic Activity...
D8IGA2
MNDTSIIVLVQQTLWTFMLLSAPVLGVSIIVGLIISIIQATTSIQEQTLTFVPKMIAMLAVIYFLASWMINYISGFTVRLFNILPTIAR
Function: Role in flagellar biosynthesis. Subcellular Location: Cell membrane Sequence Length: 89 Sequence Mass (Da): 9920 Location Topology: Multi-pass membrane protein
A0A317PNI2
MSTLLLALGLIFVLMALRVPVAVSIGLAAMTATAAELGWRVFPVSAQVMVDGISSFVLIAAPFFMLAGEIMNRGGLTQRIFRLANALVGSLPGGLGQVNVMASMLFAGMTGSAISDAVGLGTMEIRAMKERGYDARLSASITAASSIIGPMIPPSVPIVIYGALAGVSIGSLFLAGLVPGILMGVALMLAILVYDRLGLCPREPRAPGSELRAAALAAVPSLALPVLVVGGIYSGLFTPTEAAVVSSAYAAVLALIYGELRIADFKQIITGVASATGALFLIVATTALLGWIVTRSGVMIEVALWLGGAVDSQTQLLLIV...
Function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system. Subcellular Location: Cell inner membrane Sequence Length: 432 Sequence Mass (Da): 44676 Location Topology: Multi-pass membrane protein
A0A2X2WNH6
MVSFRKEMLSNISDLLKHQDAIKFMTEEKKGKVCVFGSFNVDIVSYVARLPHPGETIVSQSCSFGPGGKGANQAIAASNAMCKVDFITKVGNDQLSSHAYSHLEASNIDSLTIYVSDSAPTGNALIYVSELDGENMIAINQGANVTIIDEEIINSHKNILNSNILLVQLENNLSATINAIKYARENDVTVILNPAPFTSDAKIMLPFVDIVTPNQTEATLLSGINITDIETAKKAAERIAQMGPQCVIVTLGNKGALLYDKGQFYMIPAYPAMVVDTTGAGDAFNGALAASLSKGETIKHACHYAAAFSSLAVELNGASN...
Cofactor: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. Pathway: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step ...
A0A0X8HCA8
MTRRLLIRATGAARPGQLAGLGQAMARSGARLLDINQSVTFGMVSLEALVGLDRESDLESALSAAGDTLGLEIQAIQVSAEDYQRWSVQASEPRLILTLLAPHLPAGILAEVGALTAEHGLTVELIHRLSGREPLDGGVPRDHHTQGACVECWLRGEEVDLDALREKALALGAMHGVDIAIQEDSIWRRHRRLVCFDMDSTLIKAEVIDELARRHGVYDEVAEITERAMRGELDFQQSFRERMAKLKGLDETVLAEIADTLPMMDGVERLMYHLKRLGYRTVILSGGFTYFARHLQEKLGFDEVHANELLIENGKVTGEV...
Pathway: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. EC: 3.1.3.3 Catalytic Activity: H2O + O-phospho-D-serine = D-serine + phosphate Sequence Length: 408 Sequence Mass (Da): 45026
A3DVI8
WXAGMIGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTIEAGVGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGISSILGAINFITTAINMKPPTLSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPV
Pathway: Energy metabolism; oxidative phosphorylation. Function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytoc...
A0A6N4R9U3
MKFSTGTLVVVGVIVLGLITAVTGGIGVYMAQRGPLEQPVKVIVDQGMGVRAIASRLGQANVIAHPDAFVVMVKATGMAGTLKAGEYAFEPGISLRAVVNKLALGDTENRSVTIPEGWTVKQAIDRLEAVEGLTGHAVRPEEGRIFPDTYAFRFGAERAKVLDTMTARMDKELANAWAARDTTLPLKSPEELLILASIVQKEAANDDEMPMIAAVFYNRLSKGMRLQSDPTVMYGAELEGDRLKRKDLTEPHPFNTYLFAGLPPTPISNPGKSALMAVARPARTEAIFFVADPSLTMHVFSVTYDEHRRNVARYWKDVKK...
Function: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. EC: 4.2.2.- Subcellular Location: Cell inner membrane Sequence Length: 349 Sequence Mass (Da): 37834 Location Topology: Single-pass membrane protein
D8IDD5
MKKVNVCLLGASGAVGKEMLKILQERKFPVNELRLLGNKTAGQKVIFNNKEYTIEKPTKDSFKDMDITLVAVGSDESKKLSPLAAKAGSVVIDNSSAFRMDKNVPLVVPEVNPEDVKLHKGIIANPNCSTIIALVALAPLHKFAKIKRVIASTYQAVSGAGKEGMEELQQQVYDYAEQKKLNIKAFKYQILFNLIPQIDAFDSKTGYTKEELKMTNEGRKILHAPDLQVSCTCVRVPVLRSHSESITIETEKKLTAKKAKELLSKAKGVKVVDNPSQFKYPMPLDTTDQDNIFVGRIREDISAKNSLTFWCAGDQIRKGA...
Pathway: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. Function: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate. EC: 1.2.1.11 Catalytic Activity: L-aspartate...
A0A1W9VIL2
MVLLLAPLLLYLLLKSGKVKLALGYFTQKDLDYAKKCKKDKVLKKKESKRLRKERNVFQNIWFELLDPLFWAIIWVLILNNFIAQLYVIPSSSMVPTFLEKDRVVASKLFSGPGIPLTNYQVPEVSNPKPGDIVTFNNPKVDDSTSDIHYKNVFTRIFQPFVYMLTLTKLDIDADVNGNPKVRQLVKRVIGVPGDKLCMVNDKVYKKVDGGEWFLMSDIPGQKEWGQNALFSLTNKNSMMEIKISFCFGY
Catalytic Activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. EC: 3.4.21.89 Subcellular Location: Membrane Sequence Length: 250 Sequence Mass (Da): 28696 Location Topology: Single-pass type II membrane protein
A0A8H2QYN3
MKTIGVLFGGKSVEHEVSVITGVQVMENLSKDYCVVPIYVKKDGQWLGGESLKDFKSFKNQDFSQAYPVYFKAGIPSLFHLQRQKGGLLKGDQLVEEERKIDCIINALHGTNGEDGSMQGLLEQWSVAYTGCQVPGSVLGMDKVLMKERFSHCGIQQVAYTWFKARDWKENRDQVMEKIEKIGYPLMVKPSTLGSSIGISKVKEEKDLEAAVDLALSYDKKVVIEHAVDHLRELNISVLGANGSYDLSPIEEPKSINDLLTFDEKYIHSNNKAGGKTSGKGGRNIVVPEEKVLEAIHTMARSAMDAIDGAGVVRIDFMME...
Cofactor: Binds 2 magnesium or manganese ions per subunit. Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. EC: 6.3.2.4 Subcellular Location: Cytoplasm Catalytic Activity: ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate Sequence Length: 387 Sequence Mass (Da): 43...
D8I9T8
MSISSKPIAVFDSGFGGISVLKKLLNILPNENYIYLGDNHNIPYGDKSKEEITQLSIKILDFLIKQNCKMAVIACNTITASSYDVLKEKYNIPIIEIISNGVEDIIDNTKNNNISIMATEFTVHSNMYHDKILDYNDKIKVTQVACQKLCPMIENNWYSYDDRILVLEEYVKKIDDNSDTLLLACTHYPFIIDDIKSVVNRKKTNIKNIIDPSTKIALSIKKYLIDNNLLNTSGGKLKFFTTGDKKDFNDFVSRYIKINYELERIVL
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Provides the (R)-glutamate required for cell wall biosynthesis. EC: 5.1.1.3 Catalytic Activity: L-glutamate = D-glutamate Sequence Length: 267 Sequence Mass (Da): 30558
A0A0N1LZ49
MKQSKLLIPTLRETPSDAETLSHQLLVRAGYIRQAASGIYVYLPLAQRVLEKIKTVIREELAAIDAIEMAMPALLPFEPWVASGRAERYGRALYHLEDRNAREMVLGPTHEEPFMELIKNEVTSYKKLPLNLFQIQNKYRDEQRPRFGLIRSREFLMQDGYSFHADAESLDTTYRQYEAAYHAIFRRCGIDYRTVLGDNGVMGGHDSKEFLALSGIGEELLCYSTESDYVANWKLATSLYASKKSHETFLPLDTIQGNKEWSIDEAAEAAEIDDSKIVKSHVFLVDEQLVMVLIRGDHTINETKVKLFLSGEQITPLSAA...
Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has...
D8IAD0
MNNNKKIMLSGIQPTGSLHIGNYLGALKNWADILDDYYGFFCIVDYHAITIEYDVKEMQKRIINAAVEYLASGLDPKKCSIFVQSDVRAHTELAWIFNSIIPVAELERMTQYKDKSRKNVENINAALLTYPSLMAADILLYHPDIVPVGEDQEQHVELTRMIVRKFNNRFGEYFKEPDTYHGKVLRILGLDGVNKMSKSLNNHIALSLTAEETEKLIMQKAMTDTNRKLKTDKGNPDICNVYSYHKIFSSEEEQKEVCEGCKNASIGCVQCKRMLAANINKELAPIRENINKYSNDLDYVYDVLKEGAKNASEVAEKTLY...
Function: Catalyzes the attachment of tryptophan to tRNA(Trp). Catalytic Activity: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) EC: 6.1.1.2 Subcellular Location: Cytoplasm Sequence Length: 334 Sequence Mass (Da): 38194
A0A4R1HNW4
MVARAETTTSNDGQLPDVDAWLSSVSFGRDESAQQMIRAALDRAQKAHRDQTRASGEPYLVHCLAVAEIVHHLQLDHEAVTAAVLHDVVEDTDVSLDDIREEFGEKVAHLVDGVTKMGRISEIREPLSLQQQLDHGRAENVRKLLLAMAEDVRVVLIKLADRLHNMRTLRHLSEERQKRIARETLDIYSPLANRLGIWQVKWELEDLALRYLDADAYHRIAALLDGRRIDRERHIELVKESLIEEFDRAGIQADVVGRPKHIYSIWRKMRRKNVDFHQIFDVQAVRVLVDTTAECYTVLGIVHGLWRHVPHEFDDYIANP...
Pathway: Purine metabolism; ppGpp biosynthesis; ppGpp from GDP: step 1/1. Function: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. EC: 3.1.7.2 Catalytic Activity: gua...
A0A7J8E4V4
MEPSPATVGSETTRLVSPRDRGNAGGGLRLKSLFTEPLPEEPKSVEMASHHCHRDPLPQGLTPERLRAQRQLCAACAVCCIFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFIRLLHSDYHIEGGAMLLTASIAVCANLLMAFVLHQAGPHHSHGSRGAEYAPLEEGPSEPLSLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQCKAADPISTFLFSVCALGSTAPTLRDVLRVLMEGTPRNVGFEPVRDTLLSVPGVRAAHELHLW...
Catalytic Activity: 2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out) Subcellular Location: Membrane Sequence Length: 384 Sequence Mass (Da): 41327 Location Topology: Multi-pass membrane protein
A0A9D8PRS8
MFNETVIRDTRAVVDLDRIRESVSGIRKLVGDGVEIMAVVKADGYGHGAVRVAKKALRSGAESLAVAYPEEGAELRDNGITAPVLVLGLTSPKIKGAMEKVVGCGLTQTVADTELPRALNAATPEGKRVPVHIKVDTGMGRIGIGIEDVIEYILFLKGLKKIEIEGIYTHFPSSDEADKGFTKRQIEAFLRLLKELKGMGIDIPKAHMANSGGILAHPKSHLTSVRAGIMLYGLYPSGEVERSIPLTPAMSFITRVRYLKKVPKGTTISYGRSFVTERETAVATLPVGYADGYLRILSNRRHVLVGGKQAPIIGRVCMDM...
Pathway: Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. Function: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. EC: 5.1.1.1 Catalytic Activity: L-alanine = D-alanine Sequence Length: 379 Sequence Mass (Da): 41270
F9ZBY2
MIHSIGLTGGIGSGKSTIAGILKQLGYPVYLADPEASRLINRSVEIRNDLTGLFGADLYTPRGMLDKKLLADIIFKNPQALSQVNRIVHPRVIRDFQHWREQQNSPLVFFESAILFEAGLTRHFDFIICVTASEATRLKRVILRDATNEDKVKERMQNQAADTEKCKNSDFIIYNDEDHMVVQQVLDVLNKLNLKIQ
Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Catalytic Activity: 3'-dephospho-CoA + ATP = ADP + CoA + H(+) EC: 2.7.1.24 Subcellular Location: Cytoplasm Sequence Le...
A0A968NCZ7
MDCAIPIDSTDSNRPDPLAQIVVVLHRPQAVVNIGATVRAMKNMGVGQLRLVQPVAYTPDQISALAHRSADLLHGTHHYPDLASAIGDAVYVVGTSARQHRDYPVQPDLRRAAHTLLQATQRGTVALVFGTEDNGLQRAELDLCQQVLHIPTDPAYASLNLAQAVLLVLYELRMAAVGMPAPAVPAAPAPTAAELADLEQAWVTALTELDFFETRNPAIPLRRLRRLLHRAQADRREVAMLRAIAHRITRRLRERGQ
Function: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. Catalytic Activity: S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine EC: 2.1.1.200 Subcellular Location: Cytoplasm Sequence Length...
F9ZA27
MNLVIDIGNTRSKYAFFQEDRLIGVNYRLDSILEDIRVWKEKGEKVWIFLTGSGHIDSEMQLAIKEQADYWLEASPALEVPLKIGYATPETLGFDRIAICVGAKSYYPGASLLVIDSGTCITYNYVSAEGVFLGGNISPGLEMRFNGLHRFTARLPLVTPTETYGGIGQSTEEAIRNGVMSGMLFEVQQYIECFLGQYPEGHVLITGGNAHFLERHLTPDILFCKYLSFVGLNEILKYVKKSNY
Cofactor: A monovalent cation. Ammonium or potassium. Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. EC: 2.7.1.33 Subcellular Location: Cytoplasm Catalytic Activity: (R)-pant...
A0A931ANW0
MNNKMPEMIQLVIFGGTGDLSRSKLIPGLYKLYKRNSLPDQLSILGLARSFSSRKAYLQSLEQSLKEENPEIYTKESWNNFKEYLDYLQMDFTEDIGYNKLYHHLNDQEGNQAGRHCIYYLATAPEFFPMITENLKEHRLSKSREPGWPRLVIEKPFGYSLSSARDYNSQICQVFPEENVYRIDHYLGKEMIQNILTMRFANMFFEPIWNKHYIDNIQIVSTETSGIKTRGKYYDNAGALRDMVQSHLLQMLALITMESPADMSTESIRQEKIKLLKTLADSPSLGDLRDNLVIGQYKSGIIGDRTVPGYQDEDNIASNS...
Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Function: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. EC: 1.1.1.49 Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lac...
A0A2N2KYM3
MPKGRLYLVPTPVGNLGDMTLRAIETLRNVALIAAEDTRTARKLLNHFEIAAPKLISYHKFSEKSRSPEILGVLTRGEDVAIVSDAGSPGISDPAEIIVKDAIARGFEVIALPGATALIPALTASGLPCGAFLFLGFLPTHSRERKDILKQIKDSPVTAILYEAPHRLRTTLTELYKAIGKRKVVIAREISKIYEEYIRGNLDDVLEDYQVTEKGEFVILIEAIAPDSAPDPLALKSLILAELESGKSPSEIVKALSPDYPKNLIYKLILEMKEHKA
Function: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. Catalytic Activity: cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine EC: 2.1.1.198 Subcellular Location: Cytoplasm Sequence Length: 277 Sequence Mas...
A0A1G1LN04
MSRHKTLHLHSPAKLNLYLRVLNKRKDGYHNIVTLFERIDLFDVLTFRCNAGGGIKIYCDHPDVPKGAKNLVYKAAQMLKKEHRVSAGVDIRIKKQIPVAAGLGGGSSNAATALLALNRLWRLSLTQKELLGYAKRIGADVAFFIHDCRWALGEERGDEIRRIPLKTRLWHILVVPRIKMYTKAVYEAFQPAKTDITYRKSEGYSTGPVPRNLLTNQKQNVNILIRHLRQNDLRGVGQFILNDLESSSFRLCSNLKELKETVLNHAPLGGLLSGSGPSIFGLVKTKKEAEKIRSVLRKKYSQSFVVGSL
Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. EC: 2.7.1.148 Catalytic Activity: 4-CDP-2-C...
F2I8Q2
MAESLTDRFIRYAKVNTRSDMYSETFPSTQSQLDFLEVIAGEMEELGLSQVDFDRQRACVTATLPATTEADLPVIGFVAHVDTADFNAENIQPQVHEDYDGQDLVLNEAEGIVMEVAEFPFLKDYVGQTLITSDGTTLLGADDKAGMVGIIGAMEYLLAHPEIEHGKVRIAFVVDEEIGLLGAYRFDVEGFGADFAYTPDSGRVGKIEGETFNAAQVEVWIEGKSVHPGSSKGNAINPLHLGAQIVNDLPKDQVPEKTDGYEGYFMLTQQNGDLGQVHQVFIIRDHDEAKFQERKEIFAQVVDKINSQYKRPRIRYEISD...
Cofactor: Binds 2 Zn(2+) ions per subunit. EC: 3.4.11.4 Catalytic Activity: Release of the N-terminal residue from a tripeptide. Sequence Length: 406 Sequence Mass (Da): 45128
D4G7K8
MQKKLSWKTVGFGKQNIVLIHGFGFNSEVWKNTIHQEDRNFRFHLIDLPGHGCNHQVLIESVDQVIEKIWENSPKRAIWLGWSLGGLIASEIALRYKDQVRALITVSSSLYFIQEKKDHLLWPGITEKSLKNFKNQLSENFEETIRRFLFIQNLGSNLLKKDLKSLKNSILSYPRPNLESLSFWLNVLRKIDLRKVMSKFKKPFLRIYGEFDQIVPKSVIPLINFLIPNSQSVLIKGSSHAPFISHSEIFNKIIFYFYRNHR
Pathway: Cofactor biosynthesis; biotin biosynthesis. Function: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters....
A0A0C1RZP5
MNIKQIIQEKIRSIVTFENFCDSVEVRVRFSKNRKTFGDYQIEGLSNILKSNRISLETFKRKLCYLFSKEEYIKSIKIIEPNFINIFLHERWISRQIDTIFSKDRLGISQDNYQKKIVTIIDYSSPNMAKNMHVGHLRSTIIGDTVVRVSKFLGKKVIKANHIGDWGTQFGMIIAYLKEILRKNCVKNITLEKIEDIYQRSRKIFDQNGRFSHISRRYIQQLQSGDDELLTLWNDLVQITILENQRIYDLLGVSLNKGDIVAESFYKDMLQDIVEDLKQKKIAVIHNGAVVVYLDDFKNHHGRSSAVMIQKSDGGYLYAT...
Catalytic Activity: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg) EC: 6.1.1.19 Subcellular Location: Cytoplasm Sequence Length: 582 Sequence Mass (Da): 68229
E1QXY9
MAMEPEAWTIRRMLDWTIGYLERRSDGRPRLSAEWMLSNVTGLSRVQLYTSFDRPLSADELARMHDAVVRRGAGEPLQYVTGEMPFRHIVLHCEGGVLIPRPETEVLVDAVLAHVDVAAAAGHDAQVLEVGTGTGCIACSIASERPGSHVVATDLSPAAAALAMRNRDALGLARAVDVITCDLASGVDPALKGTFDVLVSNPPYIPSDVVPTLPREVVGFEPHLALDGGADGLDVFRRLLEVAPDMLRPGGMLACELFETNAEVAAELCRRQGGWARVEVREDLTHRPRVLVAVREGDLAAGGVMVRPRKLLAVDQDRPE...
Function: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. EC: 2.1.1.297 Catalytic Activity: L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release...
A0A2H1VBT9
MCEVVFQCSSDTELALELNEPVFLEDDDYATRAPASPTTVPNVRPYRPPSTGSNILKSPRARRVRTTSMSQPNKRTTAESILHADRRTIYTAGRPPWYNCTGGQEVEPFLIGICGASASGKTTVATKIIESLNIPWVTIVSMDSFYKVLNEKQHQAANRNEYNFDHPDAFDIELLISVLQRLREGKKVEVPIYNYVTHSRENRTKTMYGANVIIFEGILAFYNAEVTKMLDMKVFVDTDADIRLARRLRRDIVQRGRDLEGVLKQYMTHVKPAYQSYIAPCMAHADIIVPRGGENKVAIHLIVQHVHKQLQLVSYCNTFW...
Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. EC: 2.7.1.48 Catalytic Activity: ATP + cytidine = ADP + CMP + H(+) Sequence Length: 342 Sequence Mass (Da): 38662
H3D6L8
MVRRVAVIGAGSSGLACAKACVEEGLEPVCFERGHDIGGLWNFREWSEPGWAGVYRSLVANTSKEMMCFSDFPMPADYPNYPHNSQMLQYLRLYAEFHLLPYIRFQTTVTRVTRRPDFSQSGRWDIETVTSDGEEEKHVFDAVLVCSGQFGYPSSPLEDLPGHQDFPGERLHSRDYRDPEAYRGKRVLVVGIGNSGGDIAVEISRCAEMTFLSTRRGAWVISRMSRQGLPVDISSITRFNQVLMELLPWSLLNGLLERALNQKYDHRLYGLQPHHRFLDRKVLINDELPGQILKGRLSVKADLRAFQGSGVLFEDGSVEE...
Catalytic Activity: H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+) EC: 1.-.-.- Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 537 Sequence Mass (Da): 60277 Location Topology: Single-pass membrane protein
A0A1M5R7R3
MGPVPVRSASPGAARRPGRRGPADYRRARRAARARPDRGAPLSEQPEDAARATPARRPRTRLLLTLAALLFLADLATKLLVVATIDRGENIRLLGGLVYLTHARNTGAAFSFAEGFTVVFTLIAVVVAVVIVRAARRLFSTAWAVALGLVLGGALGNLVDRVFRDPGFLRGGVVDFVSVFAPNGEFYPIFNVADSGIVVGGLLGAYLALRGVEFDGTRSRDRGDGAVTSS
Pathway: Protein modification; lipoprotein biosynthesis (signal peptide cleavage). Function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Catalytic Activity: Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, ...
F2I584
MAFNNMYHIIDRDDWHAYRDEITSDINVKLTEKQLEALLAFNDHLTLEDANDIYQPLTQLISIYFKNYQSLIIERNQFLGINDKIPPFIIGISGSVAVGKSTTARLLQLFLSQFFPYLDVELITTDGFLYPNEQLEHWDLMHRKGFPESYDMHELKKFFMAVKSNKQRLKVPLYSHESYDRINAYREIKSPHILIVEGINVLQFLGSDQFFIGEYADLSIYVDADTELIEKWYMERFILLRENALKDPDHYNQRYSKMSLDDALRSAKRTWENINLVNLEDYILPTRDRADIVIHKIENHYIDSIRMRRY
Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Catalytic Activity: (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) EC: 2.7.1.33 Subcellular Location: Cytoplasm Sequence Length: 310 Sequence Mass (Da): 36851
F2I5J0
MKDNKHSGRLSNILNQSNIFVPLVIAAILVFLAVGMLMHNNPLIALISFLLVIFAIILVYVAFRLIEQELNKQVYDLTDDIQTIENEILLQIPLGIILFEEDDTIRWMNPYMQNYFNSSDTLGNKIDDVDSVLSDIYHQLKERDEDDVTGHPISWDDHYLSVGLLEDQNAMYMLDITEYGRIADVADKNRLVIANILIDNYDETIASYSDRRKSTVDNFMTKQLFAWAKKFGSFIKRLDDDRFLLVTTYGELMEMEEDRFSVIDTIRETTSKGNFPLTISMGISYQEEDDEAPDIGKINEIAQSNLDLALSRGGDQVVIK...
Cofactor: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit. Function: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP). EC: 3.1.4.- Catalytic Activity: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) Subcellular Location: Cell membrane Sequence Length: 676...
Q3YRP0
MLCKLKYIVSNFGEYRLLLRLHSVEIIFLAMFPALASIALVSHSVLRACGYMILCVIGAFIMRPAGCIINDIFDRKIDSKVKRTRNRPLANGNLSVVQALKVLGVLLACACLLLACTNMYTVKLSIISMILIVLYPLSKRFFTWPQLLLGIVFNSGVLLGCTMTIGHLTLSAVLLYIGCVFWTIGYDTVYAAQDKEYDIELGLQSTAIKFGNDIRLWIGRLYIITITMWISAGIISMLHPIFYIAILIIGAIFYYQYKKSDFDNPEKCMYMFKVNVYVGLILFLGIVLGRVI
Pathway: Cofactor biosynthesis; ubiquinone biosynthesis. Function: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB,...
D8IAW5
MSENQNNSENTQNEKNSSVEKNAEKENRKEKLNTLRNMGINPFPNSYDVTYKSKDIAEQFEELEKNETEVAVAGRIMLYRVMGKSSFLTIKDSKGTIQAYIQKDKLGDEFYNTVFKKLIDIGDIVGVKGTVFKTKTGEITIYASELKLLTKSLNPLPEKFHGLTDTELRYRQRYVDLIMNDDVKEAFIKRSKMISAIREIMIENNFLEVETPMMHPLIGGAKAKPFVTHHNTLDMTLYLRIAPELYLKRLIVGGFDKVFELNRNFRNEGISTRHNPEFTMMEAYMAYANFHKVMELVEEVFSKVCFKLNGKYTSQYKDYE...
Cofactor: Binds 3 Mg(2+) ions per subunit. Catalytic Activity: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys) EC: 6.1.1.6 Subcellular Location: Cytoplasm Sequence Length: 510 Sequence Mass (Da): 58568
A0A2H1VZ36
MLLIKLWLWLLFLFKTNEALLCYNCSTTQREWSRCGGDFVPTNLGFNSTRMFLVNCTGENAMCFVRSWNARARHAWIVQRGCYLPTGDDTLPRSVNIPTRAMSCKHERHAEAEYKVCLCRADWCNSASSLVPSIAQYFYKSLTYIVGNIIIIFWTNKLPIFI
Function: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excita...