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A0A2R5HGC7
MQPYGTPAYFIWLGLALIPLVIAHAYGKKWMGYQVLFTLAFLWLTFGSTMSIWSILGFGVFETLLIKLYEHYRTREGSANKTWVFVVAVLLSIAPLFVVKLTPVIDPAHPSSIIGFLGISYVTFKTVSTILEIRDGLIKALPVKDFLYFLYFYPTISSGPIDRFRRFQKDMQTPVDREKYVEKLGKGIFFIFQGFLYNFIIGYLIQTYVLHGVAIQAVQNPGFVNMAISAYAYGLYLFFNFAGYSLFAIGISYIMGIDTPINFNKPFLAKSIHDFWQRWHMSLSFWFRDFVFMRFVKFMMVKRWFKQMTTTSNVGYLVNM...
Pathway: Cell wall biogenesis; lipoteichoic acid biosynthesis. Function: O-acyltransferase that catalyzes D-alanylation of both teichoic acid and lipoteichoic acid (LTA). D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of t...
A0A1F4VEU2
MKLVVGLGNPGEKYEYTRHNAGFLILNAFVAKKVGDGIVWLSETKFNAHVYREEGVIYAKPQTFMNRVGESVSKLVHFYNIDLSNLLVIHDDVDLIKGEFKLKKGSQAAGHHGVEDIFSKLGTSDFFRLRMGVGRPLDKKYEVEDYVLEKFSDEEISNLKDLFEKKIYDKIDGFLNL
Function: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Catalytic Activity: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+) EC: 3.1.1.29 Subcellular Location: Cytoplasm Sequence Length: 177 Sequence Mass (Da): 20209
A0A552X005
MLKALLLIIILALGLIVGPMWSGNAGSVLILAGPYSIEMSLVVATLLVAAFLLLLWLVQAIFRKLSSGKRFTLSWFYKRKQKKAEKQLAQAMHHWLSKNYREAADYAERAAPHLQQPQHGYLLAASAWQALGNLKELQRTLGLAYDSAHHDLNVRLMQLEQMTDSGQALKTARTLLQDHPKHGGVLRACAETYYKHQHLESLRELLPRIQDRDIVPGARLAEFTRASYRSLYQSAGTSSERLRELWKETPSKLRRTPAVRMAYLDVLTHRGFGAIASKVATRGLALNVFTASDLLQFDMREWRQTESLREEVEKQIKQHP...
Pathway: Porphyrin-containing compound metabolism; protoheme biosynthesis. Function: Involved in a late step of protoheme IX synthesis. Subcellular Location: Cell inner membrane Sequence Length: 386 Sequence Mass (Da): 43714 Location Topology: Multi-pass membrane protein
D5X7N5
MSKKIQRITGKTGVIGIFGFPVEHSFSPVMHNAAFQAGGLDYVYVPFEVPPERLAEAVSAIRALKLRGVNVTIPHKERVVQYLDSLSEEARLIGAVNTIVRSGDELKGYNTDAAGFLRSLEEKKVAVQGANVLLLGAGGAARAVAVQLALAGARRVGIVVRNSGWRKAEGIAEIVAGHSCAKSTVALFENAQDLIAEKGNIIINCTPVGMHPNVMEMPPFKLDTIPADSVVCDLIYNPAETLFLKTAKARGLKTVSGSGMLLYQGTLAYELWTRQQAPVDIMRTALEEALQRC
Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. Function: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydr...
A0A3B5M660
RRSAPPGEEILALPDVAVQHELHAAVQSEEEEASADISAPQLFVELNELIVDKDQEMRWKERARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRRTITHGAVLLDLEQNTLPGIAHLVVETMIISDQIRAEDRPSVLRALLLKHRSLAKHAKALNQEPTNSELETLPHPSFITSLLRTKSFILKLIPKDAEAVIVLVGSVEFLEQPAMAFVRLSEAVLLESVLEVPVPVRFLFVLLGPSQSNVDYHEIGRSFATLMSEKVHFTMPVAYFADDRQDLLNGINEFLDCSIVIPPSDVEGKDLLKTVADFQKQLLRKRRDR...
Catalytic Activity: chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out) Subcellular Location: Cell membrane Sequence Length: 705 Sequence Mass (Da): 78855 Location Topology: Multi-pass membrane protein
D2Z415
MTRRIVALDMGTVRIGVAMSDPLGSFAQGVAVWDAEGDWLSDLRDLVTSRDVSTVVVGLPIRENGTKGPSAENVEAKTEAVREAFPDLEIVMWDERYTSTIANRVLIEGDVSRKKRKGQVDKVAATVILQGYLDSLRR
Function: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. EC: 3.1.-.- Subcellular Location: Cytoplasm Sequence Length: 138 Sequence Mass (Da): 15175
D2R6X0
MHKLLTVQQHILEEQRRNHPQASGEFSWLLSGITLATKIVAAQVRRAGISADVLGATDSQNVQGETVQKLDVIANQTLLQFLGNRGNVAIMASEENDDPIVVERDRAHGRYVVVFDPLDGSSNIDVNVSVGTIFSVLRREPDPDCSRDTTADVLQPGYKQVAAGYVVYGSSTMLVYTTGHGVFGFTLDPSIGAYLLSHERVTMPDAGTQYSVNEANFEGFPLAYRKFLMQARSGALGRTYSSRYIGSLVADFHRTLLKGGIFLYPPTNSHPKGKLRLLYEANPVALLAEQAGGMATNGTDRILDIEPTSLHQRTPLIVGS...
Cofactor: Binds 2 magnesium ions per subunit. Pathway: Carbohydrate biosynthesis; gluconeogenesis. Catalytic Activity: beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate EC: 3.1.3.11 Subcellular Location: Cytoplasm Sequence Length: 336 Sequence Mass (Da): 36788
D2Z2L6
MKQVGIVEYGAGNLGNVMRALKRLGRSGVLLESPDEIPESVSTIVLPGVGAFGPAMDSLRKKGWDRALIEWADRERPLLGICLGMQLFAEGSDENGSHRGLGLIEGKSEKLDMTPLPHMGWNDISTEDPILKPFDGSYLYFVHSYGLKNSKDRAATTEAGKVAFVSAVRKDSVMGLQFHPERSGDVGHAILDRILEELGR
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthe...
D2R345
MPIPVPEVIDTLILDRKKTTMPEPDESSSSPVSATKQAVFAGGCFWCTEMAFEQLAGVSDVASGYIGGSPETANYEAVCTGRTGHAEAIRITYDPAVMTYQTLLDVFFTAHDPTTLNRQGNDIGTQYRSAIFTSDEAELAAARATIARLDASGALPSRIVTTLEPLTEFYPAEDYHQDYARAHPNQSYIMHVSTPKACKVRNYFPKLIRREYLP
Function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. EC: 1.8.4.11 Catalytic Activity: [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionin...
A0A194S762
MARTKPKSTLEPSRNPPTPSLSSTSSSSSFSRPQQPELVPVRHYLPRVPLQLFAVAFSLVAASTSQDKHLAAPARFLQALHREPLKTLPVVCAALAAIQTWFAYSLRSNRIASLARLNHKGTDAPAPAPSRAAAARGTGFRGSLATMWDAAMRGEAPTEALWKKRALRRGAHAKAAIDTSFVGEAIMVTWLGTLAIHACTVLLGAPLTSNLTSTYLFSLLVSILAILPLAIALPLSDTSARFVWLRLASTFTPTDDLELALFAPALGTLVGAWLGAVPIPLDWDRPWQQWPTTPVLGALAGHALGSLVALARIAYGGVVR...
Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Subcellular Location: Endoplasmic reticulum membrane Sequence Length: 357 Sequence Mass (Da): 38128 Location Topology: Multi-pass membrane protein
A0A3C0WVB8
METFPGQCDFGCAQEKIEFPIVFGGTFSPPHKGHLHVLHSCRELFPSSRILVVPSYHTPFKSISEMMPFQERMRLLELAMEDYKDIYPDDNMQGIDVSDIEKNAGKQIATYQLLEMLRRRIDPDGSCGNEFKFGFAIGDDILEKLDKWANPDYLRKHVRFIVFRRILAEASHLAEMRSRLAQEGFDAYYADNDIMEASSTSISQRALTNGRFSEITSSPDDDMLTPRVRGELSKMRDWL
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. Function: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). EC: 2.7.7.18 Catalytic Activity: ATP + H(+) + nicotinate beta-D-ribonucleotide...
A0A3D3SCJ1
AAYGSAADHPYFDLPEIVPLRPITADGTGNRQARLYLLELFHGRTCAFKDMALSVLGGFLRESLSRMGRKEPVLVLTATSGDTGSAALEGLSAIEGIHTAVLYPEKGTSEIQRLQMTTVGLERRFVAGIQGNFDDAQNAVKLIFARAARGEGPLAGVRLSSANSINIGRLLPQIVYYVAAWRALASRGALGAGGLMHVAVPTGNFGDILAAKYAKEMGLPIDRLICASNANKVLADFFETGVYDRRRELLMTESPSMDILLSSNLERLLYMAAGKDPARVSSLMGQLATMGRFAVNDAEKAYLADFSSGWCSDSSAKSAI...
Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5. EC: 4.2.3.1 Catalytic Activity: H2O + O-phospho-L-homoserine = L-threonine + phosphate Sequence Length: 437 Sequence Mass (Da): 46559
A0A6C1RMF1
MEYFVEQAASHREAESKIRTKYGDKARIMHHKTIRLGGFLGLFTREGVEVTGYFSHEPPKGRPETSRKSADLEEEKRKILGSVKSEKTIDMVLKELQTIKEKMDQPQQTSVPRTTDHPTLARMEELLQYNDFTPGYIAAMIKRLRATFSIDELDDQEMVEAQLVDWIGESIQIYQPERGDHPTVFVLVGPTGVGKTTTIAKLAAVHGMNGTANGSSQASVRIITIDNYRIGAREQIETYGSIMDIPVACVDSAQEMKKQIALFQDTDVVFVDTIGKSPRQFSQLGEMNEVVRACGGSAQVHLAISATTKTSDLYELLRQF...
Function: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. Subcellular Location: Cell membrane Sequence Length: 402 Sequence Mass (Da): 45160 Location Topology: Peripheral membrane protein
A0A1Y2FD31
MVGSASSVVANNQGPLSILSVCIASLSMTVANKYIVSGRNFSMNFLMLAIQSIVSAAAVDGAKRGGILDYPDFSWEEARRWAPVSLGLVSLMYSGSKALQHLSIPVYVIFKNLTIILIAYGEMIWFGGTVTSLEFASFVLMIISSLIAASPNISAWLWPPEVLPGLEGVITETSSGLGYLWVVINCLVSAAYILGMRKKIKSMGFTDWQTSFYNNAISIPVLLVASLVTEGWTSDNFSKNFPPADRSYLIFAMILSGGVAVFISFCSAWCIRVTSSTTYSMIGALNKLPVAVSGMIFFNDPVTLRSVSAVSLGFAAGLLY...
Function: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Subcellular Location: Golgi apparatus membrane Sequence Length: 373 Sequence Mass (Da): 40164 Location Topology: Multi-pass membrane protein
A0A1Y4VB41
MSDEKKKAGIRGWFRGLQSEFKKITWPDKDRLVRETVTVAVVSVILGIIIATLDMVLQYGINFLV
Function: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. Subcellular Location: Cell membrane Sequence Length: 65 Sequence Mass (Da): 7395 Location Topology: Single-pass membrane protein
A0A6P4Y6X5
MESLVEELTCPVCLELYEQPVLLPCAHSLCKTCAGEVFAEAARKPPQQAAGQEATPKQALCPSCRHEFQLPELGVEGLRRNTTLQNIVDRYREAKNTAAVTKAVPCQMCDQEPPNNAVKTCLDCNNSYCETCLATFHPMRGGLARHTLTEASAAAPKVLMCTEHPQEKVNMYCATDQSLVCSLCKLVGKHKDHEVAAVSDTFQQKKTSIGGRVAGLIQQNAEVECFVDKIQGTMTKAEQNCTDIQERVEAFAQTLTTAIVKRKGILQLKVAVEKDQKLRTLGKQLDQWADTGTGITAAIAEAETLLNEEDPIAFLQASKA...
Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellular Location: Cytoplasm Sequence Length: 705 Sequence Mass (Da): 77393
A0A8B5WKV6
MTALDARRLGVKTIILDPEPAAPARFYADDFVCGRLDDETAIRRVVSAADVTTFEIEHISTDVLLRLEAEHHVFHPCAEVLATIQDKLAQKKVFKRAGVPVPRFAPADTEWTEWPAVWKARRGGYDGRGVQVVDGPADVPSGVPGMLEVMIPIATEIAVLIVRGADTEAVFPVLEMSFEAGANICTEVFAPAAIPRDIAERATKIGRETVSALGGRGVFAVEMFVTPGGELYVNEVAPRPHNSGHLSIEACETSQFEQHIRAVLGLPLGSTGLISPASMRNLLGAADGEIGRTCVSGLDAALAVPGARVHLYGKSECRPN...
Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. Function: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimid...
G9WZR0
MKKITNKEKYRVLEKSDLQNLKDMNEEIKKSRFRQKFHIQPITGLLNDPNGFCFFDDEWHIFYQWFPFGAMHGAKNWYHMTSDDLVSWKNKGLALKPDTVFDNRGVYSGSAIIYDNKLNLIYTGNHKDERDIRHPYQCVAVLEDNEKFVKKDEPIINMSQDYTEHQRDPKIMYVDNKYYIILGAQDKNLKGRALIYVSDDIYNNWKLLGELKVKGYEDFGYMWECPDLIKIEDKYVLIFSPQGLQANGYKYNNIYQNGYIIGKMDFETLEFIPESEFEELDGGFDFYASQSANQNIYENTAVLIAWMGLPDSSYTTDDEN...
Pathway: Glycan biosynthesis; sucrose metabolism. Function: Enables the bacterium to metabolize sucrose as a sole carbon source. Catalytic Activity: Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides. EC: 3.2.1.26 Subcellular Location: Cytoplasm Sequence Length: 496 Sequenc...
D2Z8S0
MFDALKERLDGVFGKLKGKGKLTEGDVQEALREVRRALLEADVNYKVVKGLVENIRRRAMERSVLDSITPGQQVVAVVYEELMDLMGSEPKPLTISPKPPTLMMMVGLQGGGKTTSTVKLAKRLSKGHKPLVVACDLRRPAAVDQLRVLAESAGVGFYGPEKGESDVLNVIDGALRYARDRLMDVILFDTAGRLTVDDEMMAELDAMKARIAPHEILLVVDAMTGQEAVSVSEAFHSRMDLTGVVLSKVDGDARGGAALAVLATTGVPIKFAGVGEGIDALEVFDAKRMAERIMGMGDVVGLVEKIEQATSEEDVKRLSS...
Function: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP recept...
A0A813CCM0
MAGIQAQTRKAAKIFQSETMARRGVLAVALLAVAATVALRSATAFLPVSKPLLRGGAAGALATSAAAVGALPALAEEEGGLLNFGKVELGGGFALNLNIPDINLVNISILVAGLFYFLGPLLSESMASREKEIQSDIDDAIAKYNEASTRLAEAKKAKEQADAVVKEINESIAKDVKEFQATLDAQAKKSMEAQDKAMDSSLKDMESRSASNLEKYIDSAAVKRGLVELQNLSSSQKTKFMDAAINSLCWCKIPVLSFVSCVDFFEASHHGTCPDFEQALVSMGKRGEKWGQYNGYYSYDSRSWAAWPGPKSKPQNNTAA...
Function: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During c...
A0A813CML5
GEAKSYDTITETARSDSQSSDLLTENSHLLDPSSDPEPAESLLALLQDGNDVAICRDGVDAQPTTYAELRQQLEDQSFASFFRRDDRVALVLENGKEMATCLLAVMHRACAVPLNPTFTEAGYASVADAAAQQNTEAVIEMLSQGYRADIQDSDGNTALHYAAWFRLDSLLTPLLEKRARPDIPNNSGECAVHWAAKSSNVMALDAMTRVNRALLSMRDCDGFTAFIVSAQTDNCPVMEWMYLKGVSLEEQDDQGRTALQWACHKGNKKTVQWLLSRSASIVHRDREGMTALHWAAMQGHTIITEMLMEVGAVDLLDVPD...
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 782 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 87478 Location Topology: Multi-pass membrane protein
A0A2N1TG32
MPYNMKKADMKSITEGYGLHPNRKYGQNFLVDDYTTDKLLKIIDIQTGDRILEIGPGLGALTGKMTERCSRLTAVEIDSGICRYLEDSLGSVPNFTLVHGDFLKTELEDNFTKIVSNLPYYCATEILFTVAGKFSARDIFVMVQKEMADRIMSPPGSKVYGALTVTLGYYYRARAVLQLGNDVFHPRPDVGSTFLHLSRREPRELDDAQLEMFHLLVKSAFWGRRKTLLKTLSESPHLRLEKNLVRSVIAEAGIDEKIRGEELSSGDYIRLALLFAKNDNM
Function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Catalytic Activity: adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) +...
A0A1Y3AKR4
MNSVKIRDEEEFTTNLLENQWPDTVQLDIATGYFNLIRKYQKKLIHQPPPSPTITILMASEEANGFYQGNGLLRYVPYVYTYYVRNFLRKINTMYNPITIRYYNRPNWSFHGKGIWLQTSEYYLTMVGSTNFGYRSVYRDNEAQLVIVTKNDQLKKKFQSEFDHLIEHSHKIRNWQTDLPRIPLLIPFIANIFRSLF
Pathway: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. Function: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-...
A0A0G1IHL1
MISPQQYLENLVKKAARKLTAKLPHFEMESKNISRFGDYSSNVAFSLAKILKKSPIEIARKIKSDLEENRYLDKIEIAGGGFINFFFKKDFWLEMFKNPLAKINPGKGKKVIIDYSSPNIAKPMHVGHLRATLIGDFLARLYKFLDFKVIGWNHLGDWGTQFGMLIAGYKKWGDKKKINKEPIRELLEIYVRFNREIKNNPRLLKQAQEEFAKLERQDKENKKILNWFLRVSLKEFNQLYKKLGILPFSVVKGESEYEKQLIPLINDLKNKGVAILSQGAYIIPLEKYSLPPALVQKSDGATLYLTREIASLIYRVKKYQ...
Catalytic Activity: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg) EC: 6.1.1.19 Subcellular Location: Cytoplasm Sequence Length: 562 Sequence Mass (Da): 64169
A0A0G1XKI8
MGKIAAPLGIGVDIEEIKRFRGKKLPRDERFLKTIFTPRELTYCFGKSDPGSHLAARFAAKEAAWKALTAAKKLNSHLAPFLRDVEILNETNGVPRMTFFSPKLRMRSASVSLAHSRTYAIAIVCVS
Function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Catalytic Activity: apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] EC: 2.7.8.7 Subcellular Location: Cytoplasm Sequence Length: 127 Sequence Mass (Da): 14120
A0A1V6FZQ0
MIEINFTLIIQIINFLALIYILNIVLYKPILKVLEERDQRIDGQQADAKKVVEDCQALMVDYNQKLYNAKVEAMNAKNAARNEASEQANGIINDARKKAEETISQMQEQMASEIAMAKKELEPELEVMAATIAQQILGRKAA
Function: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). Subcellular Location: Cell membrane Sequence Length: 142 Sequence Mass (Da): 16010 Location Topology: Single-pass membrane protein
A0A4R1BSG7
MANSALLEDGILDAGLEDAEAKRELARLFDRNFIDLATEADAIRRELHPNDIVTYIVDRNINYTNVCWVACSFCAFYRTKRQEQKGDGYTLSIEQVLQKIQETVDLGGTGILMQGGLHPDIGMEYTTDLIRAIRREFPQVHVHALSPAEIWHLVDKSGLSLEEVLRELKAAGLMSIPGGGAEILTDETRRRISPAKNSTQAWMEVMETWHSLGMKSTATMMFGIDESYEERIEHLLNVRKLQARTGGFTAFIDWVFQPDNTTYLKKHPDFKKASSLDYLKTTAIARIVLDNIPNIQASWVTQPMKTASIALHAGCNDMGS...
Cofactor: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Pathway: Quinol/quinone metabolism; menaquinone biosynthesis. Function: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine...
A0A2E4HQS4
MKIVIKFGGTSVGNGKRINKVCDFVSKLNEKNQIIVVSSALHSTTDELVKLAESAKKGKMELEVFDIITQRHKKTASEIIHDKKIQNELLESISVLLEELEKTVNGVITVKELSNKTLDKILSFGERLAVLIISAKLRDAGIESKSFTGGEIGIMTDENFGNASPLVKVTQHNIKKNLSGLEKTVPVITGFIGVTQQGEISTIGRGGSDYTASLIGMCFDVDEIWIMTDVNGLLTANPKIYPNAKTIPQLSYNEATEMAIMGSKGMHPRALEPAKLANIPVRIKNTFDPEGPSTLINEEVNVKKDEITKAITIINNLAMV...
Pathway: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. EC: 2.7.2.4 Catalytic Activity: ATP + L-aspartate = 4-phospho-L-aspartate + ADP Sequence Length: 462 Sequence Mass (Da): 49904
Q65FJ5
MNKSVIPSLITVGNFVSGISSILLAFRGYLFLAIIFVLIGAILDSLDGMAARRLNAVSPFGKELDSLSDIITFGVAPAIITYSIVFYDAPILGLPSTLLFPVCGALRLARFNIQSENQDYFTGLPITAAGTILVCLNLFSEILGKKPFILIMLFLSFLMVSKIKVISLKGKKLLKKVS
Catalytic Activity: a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) EC: 2.7.8.8 Subcellular Location: Membrane Sequence Length: 178 Sequence Mass (Da): 19263 Location Topology: Multi-pass membrane protein
A0A7S3XYZ3
KKNKKRKSTPGRRKMAEHNDKRRKVDESKESESSSVKQPVHFLDYGAGNVRSVRNAILKCGYEIVDITRPEDIAEANAIIFPGVGSFGAAMQNLRDKGYLEPLRAHLQAGKPYFGICLGMQTLFEASEETPGVEGLGIIPGTVTKFDSTQCSVPSIGWNGVLKHKQSEIVAPIGEHELVYFVHSFRALMTEANKDWVLTSTTYGGSNYISAVQKGNILATQFHPEKSGQTGLKIFEAFLSRAGQLDPEPTPIEVPADATTAIAKRVIACLDVRSNDAGDLVVTKGDQYDVREEGDGDQGGKGQVRNLGKPVALCARYYQD...
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR...
L8HDV4
MTSTLPRRLALEEVNAFNAEDFHRLFDSIFEHSPWVTEGAWQLWTGSYGKVPLRSAVHLWSLFSVALYGASKEDQMRLIRAHPSLGDVARIATDESRSEQRGAGLLSNLTPEEHAELLRLNSAYSSKHAFPFILAVKGHDKHSIVAHLRRRAENATEIEFDEALDQIARIGWFRLLDKIDDGRTPPSTQPPTSLPPTKAGL
Pathway: Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3. Function: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. EC: 4.1.1.97 Catalytic Activity: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (...
R4YS31
MSTADRWLLPDGIEEVLPPQARGVEQLRRHLLDDFDRWGYDFVIPPALEYLDSLLTGTARDLDLQTFKVTDQLSGRLMGLSADTTPQTARIDAHSWAQEGVSRLCYCRTVFHAKAPSILAGRTPTQIGAELYGEAGAGADIEIISLMLNTLQQAGLQDLHLDIGHVGIFKAFSAKAQLSNVAEEKLFALLKVKCATDLDAWAEEYLTDPALTTAFKAIVRLQGGIEVLDQVAEKLAAVVPEVTGIIEHLKQVCQAIAARYNVPMYFDFTDLRGYNYHTGLVFAAYVPGYGDAVAQGGRYNETGAVFGRARPATGFSADLK...
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. Function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Subcellular Location: Cytoplasm Sequen...
V7N473
MQCCVLLKYGEMVLKGGNRRWFEQWLLTNLDDALSAWPPEHRPAVRRRGGVLVLFTSPALQDELVALARNLIGISLVQPVWRVPRSARAAETAAVELLRDHCTQDGAPTFAVRCHRRDKRFGLSSEQLAARIGARVRADLGWRVDLSHPELELTVEVDRREMFLGTRTHPGQGGLPVGSSGRAVVLLSGGFDSPVAAYRAMRRGLACDFLHCTGAPFTDASSTYKAYALVRQLTRFQPRSRLYVAAVGRAQRTLAASGAGEAQIVAQRRLYLRLACGLAERIGAQAVVTGDSLGQVASQTLPNLAATEQAATLPVLRPLL...
Pathway: Cofactor biosynthesis; thiamine diphosphate biosynthesis. Function: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarb...
A0A6H1A2G9
MTTRGPFDVWAPRPERVRLLLGDPAQGPVIAMSRGDDGWWTPDEPLPPAADEPSVDYGYLLDDDPDPRPDPRSRRQPAGVHGLSRLERTSWTWTDESWTGRQLAGSVIYELHVGTFTPAGDLDAAIAKLDHLRSIGVDFVELMPVNAFNGTHNWGYDGVGWFAVHEGYGGPDAYRRFVDACHGAGLGVVQDVVHNHLGPSGNYLPLFGPYLKQGSNTWGDLVNLDADGSPEVRRYILDNVRMWLEELHVDALRLDAVHALSDSSTPHLLEEMAVEVAALSAHQRRPLTLIAESDLNDTVLVTPREGGGLGLDAQWSDDFH...
Pathway: Glycan biosynthesis; trehalose biosynthesis. Catalytic Activity: hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-[(1->4)-alpha-D-glucanosyl]n trehalose to yield trehalose and (1->4)-alpha-D-glucan. EC: 3.2.1.141 Subcellular Location: Cytoplasm Sequence Length: 843 Sequence Mass (Da): 91557
A0A151U105
MASSLILRASRRFVKPAYAASLLIPTQQFVSQSPTTPSPPFKPTQLQNFNFEFRKSVGCVSNFHLVAYLSTSPSKEDNKQSGNVSSSGAGDTSWIDLYLPRQVQPYARLARLDKPIGTWLLLWPCMWSISLAATPGQLPDFKMMALFGCGALLLRGAGCTVNDLLDRDIDTMYFFLSALILIGDIEIVILCCKLIVERTKLRPVASGLLTPFQGLCFLGFQLLLGLGILLQLNNYRKLTTPNTFDIFIGLNTPYFGCLILVARLLISSHEEVYILGWAAVKGSLDPSVVLPLYASGVFWTLVYDTIYAHQDKEDDLKVGV...
Pathway: Cofactor biosynthesis; ubiquinone biosynthesis. Function: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, ge...
A0A2N1JB77
MSTKHIYEVSNGLVEKAVYGAAASNPSLRVFSPHRVVYDASHALDKVGIIAGGGAGHEPTFTGYVGRGMLTTAVSGDVFASPSAAAISSGVDLTPTEKGLVVIVNNYTGDRLHFGLAAEKARTVFKQEKKGKEVEMVVVGDDVSVGREKGGLVGRRGLTGVAFVCKALGAAAEADWETKKLGEFGRVMVDNIVTCGSSLDHCHVPGREKGDEERGALGPNAIEIGMGIHNEPGVQHIDDKPSSEDLLKHMLKLLLDQNDKDRAYVKFEKSDDPVLVINNLGGMSELELFAIAADVKRLLQSEWGLKPVRVYVGTYITSLN...
Pathway: Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2. Function: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde. Catalytic Activity: ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+) Sequence Length: 621 Sequence M...
A0A354ZED5
MIGAFESNSRKAPRSIPMEKRTKIVATTGPACGDLATIRELIREGVDVFRLNFSHKTYDEANNEVTMIREARKALDKPVAIMADIKGPAVRLYGYTEPLAIQPGAELTIESTEAVGIEKLAAKKPMQVYTNLPDIDRICAVGQKVILMDGYFTGKVVRKVPKGIVMALENEGNLRPKAHLTLPGVDYPLPFLSEKDISDINWAVEQDIDYIALSFVRCETDVEEVKRLVQRTALAQGKNTLIKLIAKIESARGLENIDEIIRTADGIMVARGDMGVEMSIENVPIAQKQIIRKCYLAAKPVITATQMMESMMENPMPTRA...
Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. EC: 2.7.1.40 Catalytic Activity: ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate Sequence Length: 503 Sequence Mass (Da): 55652
A0A352ZBQ9
MRIALLGGSFNPPHIGHIILAEEILGTLDYDRVLFIPANIPPHKEPQGDPGTDMRLAMLHATLEGWSEFAIEPCELKRPGISYTIDTLREISRKYSFDGKPGLVIGDDLAPDFLKVWKDPELILEYADIIVAHREHAEELILPYAHRYIDNLLIPVSSTLVRERIANHGAWRSLVSPGVQEIIETYGLYRNI
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. Function: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). EC: 2.7.7.18 Catalytic Activity: ATP + H(+) + nicotinate beta-D-ribonucleotide...
A0A354ZFB4
MVTIAFPESLKGLHIHLVGAKGTGMTALAEILHTRGALLSGSDVADVFYTDGILHALGVKLFESFDARHVPEETDIIIYSAAYSLAANPELKAAIQRHIPIFSYPQALGALSLHSRSAGIAGVHGKTTTTAMAGILMEALSMPATVLAGSAISNFNGRCTLIRGGDYFIAETCEYRKHFLNFKPSWIVLTSVESDHQDYFPTYESIRDAFVEYVLSLPDNGVLIFCADQPGAVDVADIVLQKRKNISFVEYGFSAKGKYKIRDFQTSAGTNTFMVSDAPKPLQLHVPGRHLVLDAVAAIALAESIFEAQTSRNFGQDEWN...
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. Catalytic Activity: ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine EC: 6.3.2.8 Subcellular Location: Cytoplasm Sequence Length: 531 Sequence Mass (Da): 58204
A0A812JXE5
MVLPAAALNDPRGQEVDETSLSKGRLDWLLQVIKSAPLALASELSHHRALFPLAIAQMTLLADQPLLSTNMSAVANEFGFAGAEKDEKLGGIVSVVFFACGVVSSLIVGRLADVMKRSTLVCLCMLIGSTGTFSNSQAESFTSLLFGRAAVGAAVGGLIPTSFAVIGDMCPAEERPHAIGVVCIISGLGLPVGQSLAGFAGSASGWRAPFAVVGIAGWCVTLLLFFIHEEPARSNDQHLSHDVSSWSALTKPTVLCICSQGVFGCIPWAVIGTFLTDYLAVNDGMGVAGATSVLFCMGVGFIIGTIAGGKLGQHLYKKDK...
Pathway: Protein modification; protein glycosylation. Subcellular Location: Membrane Sequence Length: 849 Sequence Mass (Da): 91829 Location Topology: Multi-pass membrane protein
A0A1E7TUS6
MNSEFSKAQAGSYAFIGGGQMATALISGLIRAGLPPRAIVVFDPDAAQQERLHASLGVDVGGRVDDRLAGAEVVVWAVKPQVLRQAVQQASAHLRAPLHISIAAGIRCVELSGWLASARVIRAMPNTSALIGASVTGLTAAPEAAPADRRVAQDVLATTGHCFWAENDERLNAVTAVSGSGPAYVFHFLEAFQAAAQAVGFDEVTARELVLKTVAGAVQQAQSGDAFGTLRERVTSKHGTTEAALAQLDAARTAQALKDAVAAACTRAEAISREFAQQA
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Function: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Catalytic Activity: L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH EC: 1.5.1.2 Subcellular Location: Cytoplasm...
A0A0G0QQZ8
MSEINTENAQASGNQNDSGTSLSYDLLVFLWEVAKVVLISLAIIVPIRYYLVQPFFVKGPSMESNFHDKDYLIVDEISYSLGEPKRGEAVIFRYPANPKEFFIKRIIGLPGEEVLVRDNKITIFNRENPEGIILKEEYIDSNQVTSGNMRTRLDENEYWVMGDNRMNSHDSRAFGPVNKSYFIGRATLRLFPFDRIGVIKSPTY
Catalytic Activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. EC: 3.4.21.89 Subcellular Location: Membrane Sequence Length: 204 Sequence Mass (Da): 23401 Location Topology: Single-pass type II membrane protein
D2R5T5
MTSARQTVSYLTSRFREAGIRPEIRHGQNFLVDLNLLDLLADAAQITEDDVVLEVGTGLGSLTSRLAERAAEVVTIEIDERLAAMAEEELEDFDNVTLVLRDALESKHKLSTEVMDIVRAKLAEAPGRRFKLAANLPYNVATLIISNLLASDPCPVSMTVTIQKELADRIVAPHGTKDYSGLSIWVQSQCEAKIVRIIPPQVFWPPPKVHSAILHLEHSQALASQLRDPAYFHSFIRAIFLHRRKFLRGVLAKLFDGQLTKNDIDQLFVEKQLTPETRAEELPVATLVELSHWLLDRGLKVELASDQK
Function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Catalytic Activity: adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) +...
A0A137PEH3
MKYQLKYHDNVFDIEAEPYSKISDLRLQAEQHFGLQENTVVLFYGNALEERKCLGQVGIRPGATILVYLRPGSNSALRTQNPIPSKSIYSHQEPIRKGKYISSNDHRSKYNNNSSNYNTGSKNYRSQYNNNDNSKYNTESSNYRREYNNRSNYNTGSNSYRSQYNNNSNYNIGSSSCRREFNNNSSSKYNTESKKNRDCSLCKDKRSQKCTRCGCGICFEKNPENLIRCTKCPKNYHTQCLQISLNSIPKNSWVCPGCIRENGHNPRIDRAQSSHHHSSNNSNFSNYHRTQSSNNLVRDTNVKLEPRSASISNGYHSPNS...
Pathway: Protein modification; protein ubiquitination. Catalytic Activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC: 2.3.2.27 Subcellular Location: Nucleus Sequence Length: 7...
A0A084JFZ7
MFFNNFLLLFQFITRIPVNISLACEKENFKKATLYFPVVGAILGAIEYLIFYITSIWLPLPMVAIITVIVGIFITGGLHMDGLGDTCDGFFSFRSRERIIEIMKDSRVGSFGVLAMIIDIAVKALGIYYIGTKSIGYMIIVVPMISRLFTVFIALIGKSAKKEGTGNFYIGNTNGVYFTGALTLTLLIGSLFFNIKYIIILLLGGLIVTIIFNLFCNSKIGGHSGDTLGANNEIVELALFILISSMIF
Pathway: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. Function: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-riba...
A0A3B5LHJ7
TTKTMTNMDYEKPVDYESRSSYSFSVEVLNPIVDPRFLRRGPFKDRASIRVAVLDADEPPRFSRSKYHMDVSENCPPACTVGRVSAVDPDTGLTNNIRFSIDPQSDPEALFRISPETGLITTAMELDREREHWHNITVIASQRGQRPHRCVIRAFFLLLLFTGLCPTASLVLLSQLQPLSRSPSSTLTLYVPLVLRDGTSGLTSTGTVTVSVCPCLRGGALCLPQQSMLPSPGLSTAALLAILACVATLLVSALSLSLRRQKRDSLSPLEEDDVRENIITYDDEGGGEADTAAFDIAALQSQMGLGGYVLGRRDMSPQLL...
Function: Cadherins are calcium-dependent cell adhesion proteins. Subcellular Location: Cell membrane Sequence Length: 451 Sequence Mass (Da): 49576 Location Topology: Single-pass type I membrane protein
R6PI92
MRELEFLKVIQNTLADSSLIGDDCAYLEEFDICVTQDTLVEGVHFLTHTTTPFKLGQKAVNVNLSDLAAAGARPLYITVSLSLPRASDENFVQSFYQGVQDSCQKYGVKVAGGDLTGADNYFISICAIGKKYNNVKVSRSFAQKGDIILTTGTHGDSAAGLALLQNGINKPKNLINKHLVPLPAIEQSEYIMQTLKDAGIEKLAMMDTSDGLQDAIFKLSKASNLEFDIETIPAGKDLKTTFPKDWKDYALWGGEDFELIFTIPPFLYKYFNTPQFIKIGTVSDRPFSNALEKEFEQKSFKHFEE
Pathway: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1. Function: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. EC: 2.7.4.16 Catalytic Activity: ATP + thi...
A0A8H4X903
MFTRVFMGGYFSKSLARFMIRFSSWWLGAAFIFLYMWTVSVINAVHRGTTAATVSQWYFHRNAGPATPSREIVAAALNHALTTIFGSICESTLLSLLIRAPLIFLPRRLGAAVANIASFWIPTPVVALMNPLTITYSAIHSQNLATSARGLDQMELVSPAIPTTTLTPRALRHRGQPNGLLPYRLAKLLLVATRLIMATGLGFAGWVITAKQLRIQMPDGMGVRGSAYAYVVGLMASFIGYS
Function: Probably involved in transport through the plasma membrane. Subcellular Location: Cell membrane Sequence Length: 242 Sequence Mass (Da): 26454 Location Topology: Multi-pass membrane protein
A0A6N2E830
MADKERYQMLVIGAGPAGYVAALRGARLGLRTALVDKRPTLGGTCLNVGCIPSKALLDSSEQYHKALHGLEAHGLKLTGVTLDLPTMMKRKDSVVEKLTGGVAMLCKKAGVDVYTGTARLVDAHTVEVSGGGGAGGSGGAGGENGAGSESMSISELTANAVVLATGSVPVELPSLPFDGKQILSSTEALSLETVPKQLAVVGAGAIGLEMASVWARLGSDVTVIELQPNILPGWDPRLSKVLQQEMEKAGVKFHLGAQVEESKQSKKGVSLSVKLKDGSSATVEAQKVLVAVGRKPYSEALGLEALGVAGEKGRVTVDEK...
Cofactor: Binds 1 FAD per subunit. EC: 1.8.1.4 Catalytic Activity: (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH Sequence Length: 487 Sequence Mass (Da): 50222
A0A9D9M8Y5
MQKVFADTRTLDADARKKYSITEEVMMENAASALEKEVLEFLAGCSTPKPVVLIVTGTGNNGGDGYALARRLCGKTLSDGRKINVCIFAPKPPKTEIAVFQKETAVKTGVSFVNTLENTNPDVLVDCFLGSGLSGKLTQDAENLIKRLNEIKAFKIACDVPSGLSAESDTFFIADKTVTMGALKTQLFCENGKDSAGTVVCADLGISRDCFELSDSAVQPEAYLLEKADLLLPHREKNNVNKGTFGHLAVWGGEKRGATVIASKAAFAFGTGLVTVVDNANNGSFTVPEDILCSNTVPSNISAVAAGMGLGAFCDTAVSY...
Cofactor: Binds 1 potassium ion per subunit. Function: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that...
F2IA69
MADGEKIIQINIEDEMKSAYIDYSMSVIVSRALPDVRDGFKPVHRRVLYGMQDLGVYSNRPYKKSARIVGEVLGKYHPHGDSSVYDTMVRMAQSWSLRYPLVDGQGNFGSVDGDSPAAMRYTEARLRKIAEEMLDDLEKETVDFAPNFDDSLQEPTVLPSKIPNLLVNGASGIAVGMATNMAPHNLGEVVDAIIGYVDNKDIEDEELLQFVKAPDFPTGGIIYGVDGARDALLTGRGRIVIRAKAEIEESGGREQIIVTEIPYQVNKADMIKKTADLVNDKKIEGISDIRDESDRNGMRIVYELKRDAIPNVVLNKLYKY...
Function: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of ...
B2KEI7
MKIIFMGAGKMGHAILSSAIQKKALKKADVVVIKRNTGDLKKEGYKVFNSLSELPSGYLADLIVYTVKPNILEDIIEESKPYLKEDGFVISIAAGKTIKTMQNILGTKTAVVRAMPNLPIAVGYGVTGMYASNQVSKKQKDFCDKIFNSSGISFWLKKEADINKVIGAAGSSPAYIYAVISSLEKVCLGYGFSKELSSKISKYLLLGCAKLMQQTGDSPEVLNKKIATPGGTTEAALNFLAKNKILDKLILKAAKKAETKFPF
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Function: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Catalytic Activity: L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH EC: 1.5.1.2 Subcellular Location: Cytoplasm...
A0A1Z8VS05
MNDDNLLIFLTNDDGFKSEGFDFLKKISKYISKNIWSFAPKENQSAKSHAITINKNINVKMINYKEYIVTGTPSDCVILGLEKLKHSLKENMLLISGINQGVNLGYDLLYSGTVAAAREGALNGIKSVAISIDNKNKLAEWSGVECYVPKILDLYIKTKLSNNFFLNINLPNIEKKKIKGIKIVSLGDRKPGKLKKINNNYYTMPSERNISKTAKPNEDEYELKKGYITITIHDRTNLVVNYKDILKLKKIFRKKFE
Cofactor: Binds 1 divalent metal cation per subunit. Function: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. EC: 3.1.3.5 Catalytic Activity: a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate Subcellular Location: Cytoplasm Sequence Length: 257 Sequence Mass (Da): 29261
F2IGK5
MINFPTCKINLGLHILRRRNDGYHELETAMLELPFNDVLELIESEESTFTTSGLEIPGLGNLVLDAEAEFRIHKSIPTLAFHLHKLIPMGGGLGGGSSDAAFALKLMRDRYAPEIENESLKEMASKIGSDCAFFIDGGLQFATGRGEVLTPLNIDFKNLFVVLVNLGIHVSTKDAYEGVVPNNDRTSLKEILEKPIRMWKDSLVNDFEKSAFAKYAELEDIKNDLYNHGAIYASMTGSGSTIFGIFESEVESIQWSHKVMYEKYLKL
Pathway: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. Function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. EC: 2.7.1.148 Catalytic Activity: 4-CDP-2-C...
B9YC58
MNKGNFGTLQDGRSAQWLEIENDKLRVRVSDYGATLVSLWVKDAQLDAVLGFDQVEGYQQSVKYMGAMIGRVANRIKDGQFTLDGQVYTLYRNDKGNTLHGGQEGFDAKLWTVREHTSQTVTLELLSPAGDEGFPGELTVTVTYALAGSRLSITTRTRTTAATPVSLTNHAYFSLNGQHPSLDGHWIQVDADEIGLLDPNGCTRPETLEVEGTVFDLRQPKRLTEILNQHHSQLEIAGGLDHNYVLNGVGFRPVASLVKGGLTMRVLSDMPDMHVYTANFLNSEVGRGGTRYTPHCAVCFETQYYPNSVNDPSKISCILN...
Pathway: Carbohydrate metabolism; hexose metabolism. EC: 5.1.3.3 Catalytic Activity: alpha-D-glucose = beta-D-glucose Sequence Length: 339 Sequence Mass (Da): 37375
A0A662Q0P1
MTSSRRAKVLSWLLGLDLIGESVLIEGYEVDVEGVKKWIRENEVKRVLVQAPPGLRGVRRKLIDEISGELDMVFVHGGGCWGGCDLAVAHAKAVGADAIIHLGHARFLEKSPIPTFYLECRKTDPAPILAALEKSAKILQGHHKIGVGVTIQWQDSLSPVRKKLEEYGVEALTGPPIPPLRYESQVLGCGYEPLLRLSEEVECYLIVGSKFHGLGLALQTEKTVYSLDPELQRLDDLSAEVEKLLRSRYGYIEMFRRADEVGVVVSVKPGQYRMGAAVKLRETLRKAGKRAEILIMDDVEVNLLRDSGFEGFVNMACPRL...
Pathway: Protein modification; peptidyl-diphthamide biosynthesis. Function: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation f...
A0A525C452
MIDESILTKAFDAAKKARNNSYSPYSGYAVGSAIICQSDDEHRIFSGTNVENSSYGATICAERAAILNMVSNSGHKKIEAVVVVSAGEPLAVPCAVCLQVMAEFCRPDTLIAIGTPDSGIVKRYTFAELLPHPFLL
Function: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. EC: 3.5.4.5 Catalytic Activity: 2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+) Sequence Length: 136 Sequence Mass (Da): 14542
A0A3D5WUZ3
MTYQEIQAAAALLRERLGEAPACALVLGSGLGDFVDELERPVALSYKEIPGFPVSTAPGHAGRFVAGYVEGMKVLAMQGRFHCYEGWDASQIAFPVRVLRAYGVKVLLLTNAAGGVNTDFRPGDFMLIRDHINLSGRNPLVGANDERIGPRFPDMSKAYDPALRELAKGAARDLGIGLHEGVYAWFLGPSFETPAEIRMARTLGADAVGMSTVPEVIAAVHCGMRVLGISCITNLAAGILDQPISGDEVLEISAKKRPEFSALVKAIIARIGAEDAALAGMPRGAAWRS
Pathway: Purine metabolism; purine nucleoside salvage. Function: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine,...
A0A0B5I0G8
MIKMNLKPSKNKVPRHIGYIIDGNRRFARRLMLKPYKGHEWGAKKVEKLLNWCKEYGIKELTLYAFSLENFDRPKKEFNYLMNLFKEEFTRLKDHPDLKDTRIRFIGRIWMFPKDIQDIMNELAEETKNHDKFTVNFAMAYSGRAEILDATRRIANLIENGKITSREINDKLFSENLYLNSEPDLIIRTSESRLSGFLLWQGAYAEIEFLPNKLWPEFSKKDFVKCLNEYSKRDRRFGK
Cofactor: Binds 2 magnesium ions per subunit. Function: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids...
V9HVF1
MKLKTLTVSQVNDYLANYIGTNPIFSNMSVGGEVFNLKKTGYGYTFLSLKDDESKLNAITYLEKFDVQEGDFITVSGKISFYKKSGTYSIIINSYEKKGQGNNYEQFKILYEKLEKLGYFKYELKKPIIKFPQKIGIITSAKGAAVKDIISVITRRYPKVSLIIYDSKMQGIDVENNVIQGINTLSDLSVDTIIISRGGGDTDDLSVFNSQLIAKAVFDCDIPIISAIGHEIDYVICDFVADMRAPTPSIAGELSVPNLQEVYDTIDNFEKSIKISYKNIINLYNSKIDSYRFLIQSNTPYKKINQKKLSLLELTSFIEQ...
Function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. Catalytic Activity: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. EC: 3.1.11.6 Subcellular...
A0A6C1PKT0
MARRNRWKSFDAAILRRARRPFLRFFRRTVPTMTAASIRDCLPAGKRIDLGSMTRSPTRVIAGFYLAVALAATYILLGSPLAIDGIGWADAPLIVLIALHYVWGIVLVFSSSGSLPFRRSFVRRLVFVPEVLGAFALLLFLFSYIFALNANMDYVQRFIAAGGNLRLALDTRVERLLVWARVFPLVALNLGVYLLVRVSRYRAVREACRPSHEPRDAIVRPWSLVLVLLSSFLITIAQPSFVSLDGIAMLGWIGFVPLFLVLRSVRFGHGVFYGIVFGVFSTLLTSYWLGTFNLVSLAITVLFFLIYYALFTPVALLAYR...
Pathway: Protein modification; lipoprotein biosynthesis (N-acyl transfer). Function: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Catalytic Activity: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipopr...
A0A2E4JP80
MLYLIVSEFVDKMPLFILTGGPGIGKTTTVIRLVEMLKHRGVSIGGIVSREIRKNGVRIGFEFVDINNNETVILASIMNVGPRFGKYNVNIKGCKFAVQVLQEALLNADIIICDELGPMEFKSKEFINCVGSMLDLDKRIIAVVHKKLKHPIVDRFREKADFMINLDIQNRNKVPYLFLDRLE
Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. EC: 3.6.1.15 Catalytic Activity: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate Sequence Length: 183 Sequence Mass (Da): 20765
A0A4V0YFQ4
MVMAVMLSGCSGQYLVLDPKGPIGESQRDLIYISAILCAVILVPVLIMTAVIVWRYRENNKKVAYKPKWEHSTKLETLVWGVPTVIIIILAAFTIKYTYDLEPSKAIASEHEPVTIEVTSLDWKWLFTYPDEGIATVNYLKFPEGVPIRFHLTSDQAMNSFWIPQLGGQIYTMSGMAMTLYLQADEAGEYYGSGANFTGEDFSKMTFKADAVSNEDYNAWVQQVKSSSPELTMDGYHKLAEKGTSDEQSFSSFPKGLFQQIVMQYMNGSDMPMHHGNSESAGSDKDMGDMDMDGMDKDMDMGSSEHANH
Cofactor: Binds a copper A center. Function: Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I. EC: 1.10.3.- Catalytic Activity: 2 a quinol + O2 = 2 a quinone + 2 H2O Subcellular Location: Cel...
A0A8B5WXP3
MSRTTPQRSFHIESLGCAKNQVDSETIISSLIADGWHESPSDEADVIIVNSCGFIAPAKKESIDTAFGFRTAYPGRTIVMAGCLSQRYADDLAQQMPELDGVFGNRDLAGIGAFLDLIAANPRNPVSVAPPVAGVEASEPSVMPEVVGDRRRLLSPAGSVYIKVADGCDNSCAFCAIPLIRGRLRSRDPDVIVAEARLFVSRGIKEINLIAQDLGSYGRDTRDGREIVSLIRRLLEIPGEFWIRPLYVYPERFPKELIRVMRDDDRVVPYFDIPIQHASTRVLRSMGRPGDRNSHGELIRWIRGELPDAVVRTSLIVGFP...
Cofactor: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Function: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12. EC: 2.8.4.4 Catalytic Activity: [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS1...
V9HUU7
MVSYKVPATSANIGPGFDCLGMAVNIYNTISFEETDKGLEIEVIGDGSDTVPLDENNMAYETAKYFFDKVGYKFKGLKIKIHNYIPIARGLGSSSSIVIGALLCANDIAGTNMSKDEILNIANEIEGHPDNVTPALVGSITASVILGDTVEYKKIIPPDMLDTIVLIPEYEMSTNEARKILPKTYDRQDCIYNISRASLLIMAMITSDYELLSKVVDDKIHQPYRKSLIKEYDFFENIMKSNGALATFISGSGSTLMAFCHKTMSQELYEILKEECKKNNIKGTIKILSPVKEGAIKLEIGG
Pathway: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. Function: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Catalytic Activity: ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine EC: 2.7.1.39 Subcellular Location: Cytoplasm S...
N9D6D1
MSNASKFGKVAVLFGGKSAEREVSLDSGNAVLEALLRSGVQAEAFDPKHRSVTELVNYDRAFIVLHGRGGEDGQIQGTLEWLDVPYTGTGVQGSAIGMDKIKTKQIWQGTDLPTAPYRIISKDSNIDEIVDSLGLPVIIKPVHEGSSIGMSKVEKKEDFAQAIAKATEHDAIVMAEKWITGCEYTIVVLNGEALPVIRLEPPKDVAFYDYDAKYQRNDVQYGIPSGLSESDEKQLQQLTLRAFQAVGASGWGRVDAMQDEQGNFWLLEINTVPGMTSHSLVPKAAKAVGVGFDELCVAILEQTLQGTAH
Cofactor: Binds 2 magnesium or manganese ions per subunit. Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Function: Cell wall formation. EC: 6.3.2.4 Subcellular Location: Cytoplasm Catalytic Activity: ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate Sequence Length: 309 Sequence Mass (Da): 33...
A0A137NYD0
MSFRAISSKILRAPTASKLFYTPRYFSTSRISLVTKYAESHEWINVENGVGTVGITNHAQAQLGDVVYVEVPEVGAEIEAKSGVAVVESVKAASDIYSPVAGEVIEVNEALSSDPTLINTSAEAEGWLFKVKLSNEAELEGLLDAEAYKKLSDH
Cofactor: Binds 1 lipoyl cofactor covalently. Function: The H protein shuttles the methylamine group of glycine from the P protein to the T protein. Subcellular Location: Mitochondrion Sequence Length: 154 Sequence Mass (Da): 16620
A0A6I7QSZ7
MCRDQDDRWLARTLELARQGAGRVEPNPRVGAVIVKAGELVASGFHRNYGSLHAERAALSAAEPDLVRGATLYCNLEPCSHRSPRKKQPPCTEAIIAAGIGRVVIGHRDPNPAVRGEGIRALERAGITVDVRGEDADESPFLRENEVFNTVMALGRPFVHLKAAISLDGRLATTGGDSRWITDGEARTAAHRLRAESDAVLVGRGTVEADDPLLTVRLPAGEVQGSSPAPRPVVLDSLARISLESRLVRERGNELLLCLGPDAPERRRAALEARGVTVLEAEGVGGLDPASVLKCLGTAGIRSVFVEGGAQILTAFLRAR...
Cofactor: Binds 1 zinc ion. Pathway: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4. Function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate. Catalytic Activity: 2,5-diamino...
R4YMV9
MSQSILWYDYETFGADPSFDRPAQFAGIRTDENLNEIDEPVQFFCRPSPDYLPHPQALMITGITPQQCLQDGLPENEFIDQINQILSVPETCTAGYNSIRFDDEVTRYTLYRNFYDSYAREWQNGNSRWDILDVMRCAYALRPEGINWPKNAEGNVSFRLEDLTAANGIDLGKAHDAVVDVRATIAIAKLLLEKQPKLYRYLFEHRIKHKLASLVDIDHHKPLVHVSGMYGVDRGCMAIVVPICWHPTNKNSFIAFDLSTDPKSLAGLTIEQMQQRLFSKQADLPEGIERLGLKEVHINKSPVLAPAKTLTPDQAARWDI...
Cofactor: Binds 2 Mg(2+) ions per monomer. EC: 3.1.11.1 Catalytic Activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. Sequence Length: 483 Sequence Mass (Da): 55193
A0A1G6HT77
MSTLAQRSVLGSSGYPLDQIHIAGIAARGFHGVLESERKAGQDFSADVTLYLDTRAAARGDDLTETVNYATVSQDVADILSGEPVNLIETVAEQIAAAVLARPAVISVDVTVHKPQAPIPVPFVDVVVRIHRDRINAPVVASPLDVAAPDVAAPADSVDDIGADAAVGVGETEPEAAAVVEETVAPRWQAPVPTSTAALPVVISRSAETNGEPLDAPLDAPLDAALAAWAAPAPVLAPAPVLPLAAVLPTADTLPEPVEEHAPEPEPEPEPEPEPEPEPEPEPEPEPEAVEPASAFEIGATAVLPPLDEQALAEQARLSE...
Pathway: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4. Function: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Catalytic Activity: 7,8-dihydroneopterin = ...
A0A137P4H2
MTVSETIQDILNIAGFDVNSQEFAQHLDNTELSKFFAKYRSEFFLPKIGNIQPEGKTSDRPEDEVIYLVSNSLGLLNKRTKKLIEEELDVWSKKGVFGHFSHDFQRPWKDIDETSLPMMAKVIGAKVVETSIMCTLTANLHFLLNAFYKPTSTKYKILMEDKAFPSDHYAIISQVKQHGLNPDTDIIYLKPRKGEYLIREEDIFKAIEDENLALILLPGVQYYTGQVFPMEEITRLGQSRGVKVGFDLAHAVGNIPLELNKWNVDFACWCTYKYLASGPGNIGGLFVHERYANASEMNRLIGWWAHNPDTRFKMSNQLEL...
Pathway: Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. Function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Catalytic Activity: 3-hydroxy-...
A0A2N3G838
MLKAAVIGASGYAGAELMRILWGHPELEVVHATANKYAGCPVGSLYPSLAMQYPGDFEEYAPDLFNDCDIAFFGLPHGQSMKVVAEAASAGLKVVDLSADFRLSREDYLKWYGIEHESPELLGKAVYGLPELGRETIAFALVVANPGCYPTSALLGLFPLANAGYIKEKNTVIIDAKSGVSGAGRRPTHATHYPRVADSMSPYAVTGHRHAPEISGWLASMAGGAVDVVFTPHLAPMNRGILSTMYVPLEAGSSIEDIRALYYDTYESEPFVHLLAPGSFPETKAVQGTNNCHVALEVSRSGGTLVVMSAIDNLVKGAAG...
Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. Function: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Catalytic Activity: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = ...
A0A1W9PVM7
MIAVLMSGGVDSFVAAHLLKKSGADVVGVHFKTGYENADASRLQEIAALAGVPLVFLDCEREFKRKIVDYFIGSYLDGETPNPCIACNRLIKFGVCADYAVSIGAEAIATGHYCSAVRVGNRTVLGRGADTGKEQSYFLAFLSQAQLSRAVFPLGNMKKSDVKKLAHDLSFPFLTQAESQDVCFIRDTGYARFIEEHAGMEFSPGHIQDTEGNIIGRHHGVHRFTIGQRRGINIPSSRPYYVAAIDTRRNLLTVGHREDLFVSEFMVRNVNWLLEPPDGSLDLLVMVRYNQTAVNARVVPVDGGRARVFFATPQFGVAPG...
Function: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. Catalytic Activity: AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] EC: 2.8.1.13 Subcellular Lo...
A0A3C0WWK9
MTKKNLLKGLTLPKTVEYEVVEEDGGNKEYAKIAAYPFERGFGTTIGNSLRRALLSSIQGYAVSSLMFHVRKDGNLTTISNEFEALPGVKEDIVEIIANIKKLALKCSGEDFESQVMTISCKGPGELTGAAFAKNGIEVINSDLHILTMEKDVDMDIDVQIDFGRGYIPADMQKNYVVETYGVIAIDSLFSPVVRVNYSIDAARVGQRNDFEKLVLEVWTNGAISAVNAVGQAAFIVSEYLQKFINFDKSEVLNSQEIEKCENDRIELLKSSIDRLDLNSRSMSCLKRININFIYELVQKNEDELLREKNFGEKSLGEIK...
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. EC: 2.7.7.6 Catalytic Activity: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) Sequence Length: 337 Domain: The N-terminal domain is essential for RNAP assemb...
R4YKJ2
MDKVFIRGLKIETVIGVFAWEKQVQQPLIFDLTMDWDITKAAETDDLAYALNYAAVSDRVIEFVQGNQYDLLERLLVQLAETLRTEFSISKIKIRVEKPAVAPDAIAVGLEIERG
Pathway: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4. Function: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. EC: 4.1.2.25 Catalytic Activity: 7,8-dihydr...
A0A6B2C0I2
MKVGFEIHIQINSKRKLFCNCNPKSDESSQIEFRRRLRVSTSELGEIDPAAAFEIKKGLDIIYVSGDKTSCLVEADEEPPHEPDPYSVEVAIKISNMLNSFIVDEIHFMRKIVVDGSNTSGFQRTAIIGLNGSYTFRGKNVRIQTICLEEDAARLLEKGEGYVKYELKRLGIPLLEITTEPLEISPEEAKAFAESLGRTLKLTGLFARGLGTIRQDINVSVEGGCVVEVKGVQKLEQIQKVIEFEEKRQKMLLEIAAKLKERGISEENFVSIEPVEVSDVFKNHLNIPSVKKFFKDYAFALKAPGLKGLFSYETVPDSRL...
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for g...
F2IK29
MTKKCNFGLMSKRIEKTGKKGLRTSYISTVIGISLVLFMIGLVLAGVIGLDSLQKQARENLHGDLFFKSEYNAADIKQVEQELKSWDCFKEVVFVSPERAIEEFKGADQNSDEILAIFEGENPLPPTINFRPVSSYVTKKGMKEIETRLNTKFGDMLAEVNYDKAALEEVNLGFKQFAFLILLVASLLIVIAVAMINNTIRLSLYSKRFTIKTMQLVGARSGFIRKPFLKQAIFQGLVSGIIGMAFLMTVFFALNNILDVVEINLKLVDILLLFASLLIIGCVLTIVSTWFALNKYLRAKLDDLY
Function: Required for cell division and gliding motility. Subcellular Location: Cell inner membrane Sequence Length: 305 Sequence Mass (Da): 34234 Location Topology: Multi-pass membrane protein
A0A1F4VDY6
MLSTQPYKGVRDFFPDDIKVRNYIFDTWRKVCLSFGYEEYDGPFLEPFELFSAKTGDEIVNNQLYSFEDKSGRKVAIRPEMTPTVSRMAAEKIRMQTPLPLKWFSIADFYRYEKPQKGRGREFYQLNVDIFGEESVNAELEILLLNKGIMEKFGATDKMYEVRFNNRFLMNYLYERIASLTVPEIKAVQKAVDKKAKISNSEFESLLEKDIDKSKIKKVHEVLNLTISDIKKLKDLPDKASNLLKLMEMAQKVGIKNIIYDPALVRGLDYYDGNVFEQYDLTKGNNRSMFGGGRYDGLISLFIDKKVPAVGFAPGDITLM...
Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His) EC: 6.1.1.21 Subcellular Location: Cytoplasm Sequence Length: 429 Sequence Mass (Da): 49427
A0A6N2E7Y0
MIEVLDTGLEMLGMSQESPDRRTSLLRYLSELRLWNRKLGLVEAEGDELVVRHVLDCLTPLSIIKSNSPGTVADLGSGAGLPGIPLAIYMDSSEFALVERSGRRVGFLKNVVALLRLKNVSIYESDFTRHTPTQAAQAGYDLISFRAFRPFSEDLIVGIRRILSPGGVVAAYKGRDENVAEDARLLQAAGAVTETIPLEVPFLKHERNLLLARFPSES
Function: Specifically methylates the N7 position of a guanine in 16S rRNA. EC: 2.1.1.- Subcellular Location: Cytoplasm Sequence Length: 218 Sequence Mass (Da): 23978
A7TIX7
MSGQILDKNTIDILSRECIRARESSYSPYSKFRVGCSILLTNGKIIRGCNVEVASFAGTICAERTAIVKLISDDEDNNGNSTKLQQVECIGIIGDTKEGVITPCGICRQVLREFLPSKTKIVMFNNDGTQNEILTLEDLLPYSFGSDSLGT
Function: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. EC: 3.5.4.5 Catalytic Activity: 2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+) Sequence Length: 151 Sequence Mass (Da): 16502
A0A2S9V825
MSSPSKPPFILVDGSSYLFRAFHGLPPLTNTKGQDTGAIYGVINMLKSLIKQYNPTHIGVVFDAKGKTFRDDIYPEYKANRPPMPDELRSQIAPLHDIIKAMGLPLIIEDGVEADDVIGTLARQAGEQGIDTLISTGDKDMAQLVNEHVTLINTMNNQLMDVQGVQDKFGIPPELVIDFLALKGDKVDNIPGVPGVGDKSAQGLLNGIGGIEAIYQNLDKIAELDFRGAKTLGKKMAEYEEQARLSYKLATIDVDLNLDYSPQTLTPEQADNDKLADLYSEYEFKRWYTEVTSSQATPAATDSDSQSKETDEEDSAAADI...
Function: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. EC: 2.7.7.7 Catalytic Activity: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) Sequence Length: 923 Sequence Mass (Da): 103323
A0A137P308
MFSTSEKNIQGVFTSTMYYAIKQSIGPLIGTIFISSFVGLLWIFFLCNFIKPFMWFTFLSVPVISFVIFLWMLFNGIFGIDNTLIAANQSKLLSIIPLIITGGHCLFIHRYHALINHCIDIIKVSCIILRQSLDIFGVSLFCLSIQILFSSFWLILFDRLFLLGSSTTIEGKANWAQDANLIYLVPFYLFYYWWTTCIIDGVERSSIAGTVSHWYFHQEETQFINGFNATHISFRRALTTSFGSICFGGLIASVVRFIQFLRQLNDQIPQSVNFLTTILRWVMWPIVLVSDLVEK
Function: Probably involved in transport through the plasma membrane. Subcellular Location: Cell membrane Sequence Length: 295 Sequence Mass (Da): 33913 Location Topology: Multi-pass membrane protein
A0A3B5KQ85
MVRRVAVVGAGSSGLACVKVCLEEGLDPVCFESSDDIGGLWKFKESPEPDRSSIYRSLVVNTSKEMMCFSDFPMPDDYPNYMHNSQLLQYFRLYAEHFHLLQHIRFQTTVRSVTQRPDFSESGQWDVVTMNKNNEEERHIFDAVLVCSGHYTHPVLPLSDFLGHETFLGRLLHSREYRDADSFRGERVVVVGFGNSGGDVAVEISRSAEKTFLSVRDGFWVMSRMAHRGLPVDMALISRFNILLLQLLPKTLINWAAERALNQKYDHELYGLKPRHRLLDKRPLVNDDLPGRILQGALIMKPNIRAFKDSGVTFEDGTVE...
Catalytic Activity: H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+) EC: 1.-.-.- Subcellular Location: Membrane Sequence Length: 420 Sequence Mass (Da): 47812 Location Topology: Single-pass membrane protein
A0A146KIX5
GRTLKAQYTRNLMLEEVNPITDRKKRKFRDLLCVIIFIAFWIFIILLIVLNKIWTQYQNSTLLLEPHDFMRRRCGQSSNNQKDKLATDYSKLITQQDQFVQFCTVFQQVYTGVEPYDCQWLNQSQNISAIYNSRTFFNKISQTAVDTTLQSAGFSVNDVKICVAPAYLEASSSAANCNPPLEAAYVCAHDFVNFAMELISNPVLKNDIDNLVNKQFYTQSMINQIMNDVGFNNQFIIKFCQSIPAYVGNNSIRDDFAQNAIQQLFNIKTCSRSNLFFENQLFKDIGNYISDFSNNFLMQISSRWQWILVGIGSGILFMIL...
Function: Choline transporter. Subcellular Location: Cell membrane Sequence Length: 738 Sequence Mass (Da): 84200 Location Topology: Multi-pass membrane protein
C4GIC9
MRRLLFCLITSLALIAPSADAKARAAKNAEGRAIKTVMPVYPPLAQENGIEGRVKLRVQVAPNNRIRLVEVAESSGSPLLDEAAVAAVRQYRFQAASRDGKRVATTFFPIFINLNWSDKRAGADSRPALLCPCIKRQPEKHKTAWYSAKRFFYWIDSLSGCLTLHNCLMLPPSPLRSAERSILFSGKSVRLSDDVRSTASSHAPKKGCGVREVRTANLHVEVAFLLLTFLWRSKEK
Function: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the rele...
A0A9E4DEP7
MIVPSIDLMGGQAVQLIGGETRAIDAGDPFPIAERFAVAGEIAVIDLDAAMRQGSNAGLIEGLVRRFPARVGGGIRDVETALSWLDTGAVSIILGTMAVPEVLKDLPKARLIAALDARNGEVVVEGWKTGTGRGILERVAELKGLVAGFLVTFVELEGRLGGTNLDLAKEIVAAARPARVTIAGGVTTPEEVADLDAIGADAQVGMALYTGRMDLGEAVAAPLRSDRPDGLVPTVVADAHGVALGLVYSSRESVKTAVNERRGVYHSRSRGGLWRKGETSGATQELLRVDADCDRDALRFTVRQAGAGFCHTGARTCFGE...
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. EC: 3.5.4.19 Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide Sequence Len...
A0A812M9G5
MWLIWWDPCGLFCYLFGELVMVLSNYVVLVYILGPWTQWNTVGIVNGVLFQTVVCLVFVAHWRAMFVCPGVTQLNSATPADCQPDQSDPTWWTKPKRKYCTKCKAIKPPRAHHCSVAGRCVVKMDHYCPWVNNTVGQNNHKFFLQFLVYVFIGTAYAALASLAYGLAVWQGWTPWPKWSVLDIGLVVAQVVLDAFFAIFVCAMMSDQFEAVCTDTTGIEAMKRWEERDWTLMQGLTNVMGGPLGLHWFIPTLPQGKALYQWSATDDLDAYDIRDPSIKNFFRQLDFEARLQELNAAKGEEGQADAPSKPSLPNLQELIGQ...
Catalytic Activity: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC: 2.3.1.225 Subcellular Location: Membrane Sequence Length: 362 Domain: The DHHC domain is required for palmitoyltransferase activity. Sequence Mass (Da): 40921 Location Topology: Multi-pass membrane protein
A0A1J5DRY6
MEIQIQFRRRTPGLSAAKIRRKAAALLDALGCPSKELSILFTDDGHIAKLNGIYRKKEGPTNVLAFPQGSPDDLFTDMLGDVVISVDTAGREAESLGEPFEITIQRLMIHGLLHLLGYDHERSGEAAEEMEKEERRLLAMIREDN
Cofactor: Binds 1 zinc ion. Function: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. EC: 3.1.-.- Subcellular Location: Cytoplasm Sequence Length: 145 Sequence Mass (Da): 16188
W0U4J5
MSEERIPKRSEVPEQFKWALEDIYATDEKWAEDLQKLKAMPERITAFKGRLSESADTLYDFMQLSDEISVLCDSLGNYAQRRSDEDTANAKYQGFLGQLMNAYVAVNSAGSFETPEIISIEEDKLQKFYEDKPELKLYKRALDKLRRKKAHILSEAEEKILALTGEMGQSPENIYSMFSDADLRFPDAVDKDGKAHQVTHGSYIPLVQSEDRVLRKSAFESMYGTFDKFKNTCAATLSAQIKAVNFYAKARRYDSSLEAALDGTEVPVSVYKNLIEAVHDNMHYMYDYVALRKKLLGVDELHFYDLYTPVVPDADMKITF...
Cofactor: Binds 1 zinc ion. Function: Has oligopeptidase activity and degrades a variety of small bioactive peptides. EC: 3.4.24.- Sequence Length: 599 Sequence Mass (Da): 68223
A0A928CJJ4
MTNNIYDYSYQMRRNLQKKIGFIFIFLLVIFILVAITSSFFIFSKFIKSDSMSPTLEKNNIVFISPFASPSNPIFSDKNIFERGQLVQIKPLETTEISFFKQILDKIVLFFTFQKVAPFSDSTNMTHSSLIRRVIGLPGDTVYVKNCVVYVKPADSSHFLTEFEVSQKKYDIISTNSNNENIDLLKDSKEITLGNDEYFVMSDNRVSSIDSRLWGAIKSDQIQGKVLLRYFPLNKISGF
Catalytic Activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. EC: 3.4.21.89 Subcellular Location: Membrane Sequence Length: 239 Sequence Mass (Da): 27494 Location Topology: Single-pass type II membrane protein
A0A4P9A1A1
MEKLDEVRALLLSRVTEVAEPRSVLRSAELRELYGIIATLPAEERGAFGKKVNELKQELERAITAREDELSKVDLPPIDVTAPMDVNAPRPELLPSERGTIHPLSAEIERISDIFNRMGFVTEESREIDDQFHMFESLNFPKGHPARDDYDTFMTEETDANGDRLIAPAHTSTMQNRVLKKYHGNLEKGEAIAAIVPDRVFRNEDLDARHEHTFYQVEGVYVAKGVNVGNLIATLQEFLQEYYGKKLDVRVNPFYFPFTEPSFEFALSCPFCEGKNPDCKVCSGEGWIELLGCGMIHPNVLKAADIDPNEYTGFAFGCGI...
Cofactor: Binds 2 magnesium ions per tetramer. Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) EC: 6.1.1.20 Subcellular Location: Cytoplasm Sequence Length: 347 Sequence Mass (Da): 39345
A0A6I7PIT0
MNSGSKTSTRKRTMGRRTILLDLAYDGTDFCGWQVQRSDRTVQGELERALAELHGQRVVLHAAGRTDSGVHATEQRAHFHTSMDSVPSERFRDAINSKLPLDVRVLRSRRVADEFHARYDAVLRTYHYHLLVSPVQLPRYRNYCHRISRRPDMATLNRLAAQLIGEHDFSSLGLPPGDGGHARRRVEAAAFVSRPPFIVFQISANAFLWKMVRTIVATILACESCGEDAFVDILQARDRSRAQLAAPGRGLFLHKVRYHESFAID
Function: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. EC: 5.4.99.12 Catalytic Activity: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA Sequence Length: 265 Sequence Mass (Da): 30017
A0A1R1YJH0
MIASTKSIFRPCIDLHNGQVKQIVGGTLTENDQQVKTNFVSSNPSSYYAELYKKHSLIGGHLIKLGPGNDLAAIEALKSWPNGLQVGGGINIENAQKWLDLGASKVIVTSWLFTDKKFDLNKLKALCDKIGKDRLVVDISCRKDDIGWVVAIDKWQTRTDLYLNKNTIDLISHEFLVHAADVEGLCQGIDEELVKCLLIYSFSLLLCSCLGIWVDIPTTYAGGANSKNSI
Pathway: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. Catalytic Activity: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho...
K6WYS1
MEQLSGADAAFVYCETAGAAHVTFFAIYDPSTGPGKIVGFDDVFAHFGSRLGVASFFRSVLVRVPFDLDHPYWVRDENFEVGHHLHHVTLPGPGDWRTLCDQVSRLHAEPLDLHRPPWDCYVIDGLGEISGIPDGSFALCLKVHHSALDGLTGLTLVMQLHELTPETSPPPEDVWVPESRPSSLHLLARSAVTVARRPAQLASAAEHSIPAVGRLPGATLRRLLPRHGSEYLPALYAPRTRFNGHTDSTRNFDGRSYDLAAVKAVRTLVPGATVNDVVIAGIGGALRRYLLANGELPEKSLTTVIAISLHHATGRPHGVN...
Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis. EC: 2.3.1.20 Catalytic Activity: a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA Sequence Length: 478 Sequence Mass (Da): 51069
A0A2V2U9A9
MQLTIIRIEEYGPWTITLGSDREARLQMLQANFYYDLQRLFSAKDCLVYLNRFDEYFAITNGLSVADHLVIESELSSLYKKLKLSMTIGNGETPYQANLDAYNTRKMGELGTDKARIFASAAVQSSMSNSIPGVNEFVQIMHIDMNNSAEIGSKLSPYEMTCLIIKIYARLSEEFVKKESLTFFLGGDNFMVVSNAATKQDAEETIMKVTQGTNIRLNCGIGIGRTGRKAANAATKALDTIRDLRHVGKDLPVYEVECL
Function: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. EC: 3.5.4.29 Catalytic Activity: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylam...
A0A229T432
MSLVTTHVLDTAAGRPAAGVPVRLETGDGTPIARGRTDDDGRIRDLGPDELDPGVYRLVFDTGAHLGPDAFFPEVTVSFRISDGTQHHHVPVLLSPFSYSTYRGS
Function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). EC: 3.5.2.17 Catalytic Activity: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) Sequence Length: 105 Sequence Mass (Da): 11274
A0A812YER3
MQSNRVAATDFENPVGIEIPPPNAKPANERTKKNVITILGVVAFIFLVTTILFAVLYAVEANRDEDSSRGECPVQGAYVPETGDLAEFSNNVDRVKEMFDTITPEELLAVRNFAVQEWGLTPIADRSSEQFDEDYLLTTELAPAPKAAAKDYIDGVSDTSPGRYAHAFVVKGSEATPMVHVYLVGPLGGTLTATELTAPNHPYPVPFNMSALNGMVETFIADLDAENFWTTAYGLTADDIWWTDSSPRGYDRASRKTWHWFNAWGEGQYIYPLGLTVLIDHQDLDPQNWSIERIVFNGQGPYATVADLITASADSGFEWP...
PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Cofactor: Contains 1 topaquinone per subunit. EC: 1.4.3.- Sequence Length: 805 Sequence Mass (Da): 90395
A0A0G1WCV5
MVYYFNVKRVFISIPLTEVVRRQLRDLIGVLKVKMAGVHWVDPRQAHVTLRFIGEVEKSELIALSDIVSKCTADVRPFKLEIQEFEFLPSAKRARVVALSVMENVLLDSLTAALSTRLEAFGLVPLDVQPFRPHVTIGRTRAGVLNAVQYSLIHFSATCPVHTIDIMKSTLTTDGPVYTLVKQIFI
Function: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. EC: 3.1.4.58 Catalytic Activity: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) Sequence Length: 186 Sequence Mass (Da): 20919
A0A3N5TDP6
MQNTNDVRILSCVTLQSPEELKKEYPITASAAETVVTGRRAIESILVSAATGTGKDSRILAVVGPCSIHDPAAALDYASRLVSLQKRIARHILLVMRVYFEKPRTTVGWRGLILDPGMDGTGDINKGLKIARKLLVEINSMGLPTGCEMLDPIVPQYTADLVSWASIGARTTESQTHREMASGLSMPVGFKNGTDGGLETAINAMV
Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. Function: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). EC: 2....
A0A2N1J771
MRELKMRNQTTLLYSTAGLILTLGLSYAAVPLYRAFCAATGYSGTPMTDRERYSDASRLHPTYSDPFNETKDTERIRISFSATHSDQIPWSFVPEQPEIYVLPGETALTFFKAHNYSDKDIIGIATYNVVPDRIAPYFAKIECFCFEEQKLLAGEVIDLPVFFFLDKDMLEDGETRDVKDVILNYTFFSARRNPVNGQLEPDTDLSKYRVGKDA
Function: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Subcellular Location: Mitochondrion inner membrane Sequence Length: 214 Sequence Mass (Da): 24404 Location Topology: Single-pass membrane protein